## Fri Nov 15 10:44:33 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin23/SRD_2_bin.3.fa -m mmseqs --itype genome -o SRD_2_bin.3 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/SRD_2_bin.3 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
SRD2_k127_1009805_1	1051632.TPY_3518	1.046e-30	134.0	COG0247@1|root,COG2181@1|root,COG0247@2|Bacteria,COG2181@2|Bacteria,1TPG1@1239|Firmicutes,24BBE@186801|Clostridia	186801|Clostridia	C	Fe-S oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
SRD2_k127_1009805_0	401526.TcarDRAFT_1841	3.622e-66	235.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,4H217@909932|Negativicutes	909932|Negativicutes	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
SRD2_k127_1027075_23	483219.LILAB_16360	2.986e-29	125.0	COG4122@1|root,COG4122@2|Bacteria,1RB34@1224|Proteobacteria,43BAG@68525|delta/epsilon subdivisions,2X6PP@28221|Deltaproteobacteria,2YUZG@29|Myxococcales	28221|Deltaproteobacteria	H	O-methyltransferase	-	-	2.1.1.104	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	M00039,M00350	R01942,R06578	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_3
SRD2_k127_1027075_34	316273.XCV3751	0.0009532	50.0	COG0741@1|root,COG3409@1|root,COG0741@2|Bacteria,COG3409@2|Bacteria,1RFXZ@1224|Proteobacteria,1SYVH@1236|Gammaproteobacteria,1X6HD@135614|Xanthomonadales	135614|Xanthomonadales	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
SRD2_k127_1027075_18	1382356.JQMP01000003_gene1569	6.755e-37	152.0	COG2897@1|root,COG2897@2|Bacteria,2G5XI@200795|Chloroflexi,27XNT@189775|Thermomicrobia	189775|Thermomicrobia	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
SRD2_k127_1027075_28	1449126.JQKL01000038_gene964	1.397e-22	107.0	COG1196@1|root,COG1196@2|Bacteria,1VAV4@1239|Firmicutes,24NPU@186801|Clostridia	186801|Clostridia	D	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	DUF4446
SRD2_k127_1027075_6	509191.AEDB02000051_gene1333	4.341e-117	388.0	COG0003@1|root,COG0003@2|Bacteria,1TQZP@1239|Firmicutes,249JN@186801|Clostridia,3WGD0@541000|Ruminococcaceae	186801|Clostridia	P	Anion-transporting ATPase	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
SRD2_k127_1027075_20	1196322.A370_03597	5.404e-35	145.0	COG1994@1|root,COG1994@2|Bacteria,1V6D4@1239|Firmicutes,24K0D@186801|Clostridia,36HB5@31979|Clostridiaceae	186801|Clostridia	S	peptidase	ywhC	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
SRD2_k127_1027075_7	1382306.JNIM01000001_gene83	4.648e-109	376.0	COG1921@1|root,COG1921@2|Bacteria,2G5VV@200795|Chloroflexi	200795|Chloroflexi	H	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
SRD2_k127_1027075_5	1521187.JPIM01000123_gene3608	3.969e-141	469.0	COG3276@1|root,COG3276@2|Bacteria,2G5JX@200795|Chloroflexi,3770N@32061|Chloroflexia	32061|Chloroflexia	J	Elongation factor SelB, winged helix	-	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
SRD2_k127_1027075_30	35754.JNYJ01000054_gene9727	6.224e-11	73.0	2DQVM@1|root,338Y0@2|Bacteria,2I9JA@201174|Actinobacteria,4DEM0@85008|Micromonosporales	201174|Actinobacteria	S	LppX_LprAFG lipoprotein	lprG	GO:0003674,GO:0005102,GO:0005488,GO:0005515,GO:0005543,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008289,GO:0009405,GO:0009605,GO:0009607,GO:0009966,GO:0010469,GO:0010646,GO:0016020,GO:0020012,GO:0023051,GO:0030312,GO:0030545,GO:0030682,GO:0031982,GO:0035091,GO:0042783,GO:0042785,GO:0043167,GO:0043168,GO:0043207,GO:0043226,GO:0043227,GO:0043230,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044421,GO:0044464,GO:0048018,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051812,GO:0051832,GO:0051834,GO:0051861,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0065007,GO:0065009,GO:0071944,GO:0075136,GO:0097367,GO:0097691,GO:0098772,GO:1903561	-	ko:K14954,ko:K14955	ko05152,map05152	-	-	-	ko00000,ko00001	-	-	-	LppX_LprAFG
SRD2_k127_1027075_9	1120949.KB903328_gene8962	1.136e-95	333.0	COG0477@1|root,COG0477@2|Bacteria,2GQFQ@201174|Actinobacteria,4D8CV@85008|Micromonosporales	201174|Actinobacteria	EGP	Sugar (and other) transporter	-	GO:0003674,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008144,GO:0008150,GO:0009405,GO:0015562,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0051704,GO:0055085,GO:0071944	-	-	-	-	-	-	-	-	-	-	MFS_1
SRD2_k127_1027075_10	1303518.CCALI_02541	4.686e-88	310.0	COG0617@1|root,COG0617@2|Bacteria	2|Bacteria	J	CTP:tRNA cytidylyltransferase activity	cca	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
SRD2_k127_1027075_15	561175.KB894108_gene4879	4.132e-61	225.0	COG0665@1|root,COG0665@2|Bacteria,2GJVR@201174|Actinobacteria,4EH02@85012|Streptosporangiales	201174|Actinobacteria	E	FAD dependent oxidoreductase	thiO	-	1.4.3.19	ko:K03153	ko00730,ko01100,map00730,map01100	-	R07463	RC01788	ko00000,ko00001,ko01000	-	-	-	DAO
SRD2_k127_1027075_31	1499967.BAYZ01000179_gene4636	9.167e-08	63.0	COG2199@1|root,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
SRD2_k127_1027075_26	1382304.JNIL01000001_gene1199	3.095e-25	111.0	COG1971@1|root,COG1971@2|Bacteria,1V56V@1239|Firmicutes	1239|Firmicutes	P	Probably functions as a manganese efflux pump	mntP	-	-	-	-	-	-	-	-	-	-	-	Mntp
SRD2_k127_1027075_24	1146883.BLASA_0700	1.865e-27	127.0	arCOG02771@1|root,2Z93M@2|Bacteria,2I3TS@201174|Actinobacteria,4EXI4@85013|Frankiales	201174|Actinobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_1027075_0	266117.Rxyl_1326	2.821e-237	749.0	COG0129@1|root,COG0129@2|Bacteria,2GJIJ@201174|Actinobacteria,4CPCE@84995|Rubrobacteria	84995|Rubrobacteria	EG	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
SRD2_k127_1027075_32	1343740.M271_34730	1.232e-06	60.0	COG3087@1|root,COG3087@2|Bacteria,2IBKJ@201174|Actinobacteria	201174|Actinobacteria	D	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_1027075_27	1123386.AUIW01000006_gene1700	6.112e-23	115.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,1WID8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	PFAM Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23
SRD2_k127_1027075_22	56780.SYN_00925	1.236e-31	133.0	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,42TV9@68525|delta/epsilon subdivisions,2WNAN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
SRD2_k127_1027075_25	1303692.SFUL_6446	1.175e-26	118.0	COG1670@1|root,COG1670@2|Bacteria,2IGHV@201174|Actinobacteria	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
SRD2_k127_1027075_33	635013.TherJR_1010	0.0007299	50.0	28VT7@1|root,2ZHUX@2|Bacteria,1W6GG@1239|Firmicutes,255G6@186801|Clostridia,2669R@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_1027075_13	273068.TTE2791	1.504e-68	242.0	COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,2488C@186801|Clostridia,42F5R@68295|Thermoanaerobacterales	186801|Clostridia	D	PFAM Cobyrinic acid a,c-diamide synthase	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
SRD2_k127_1027075_14	469383.Cwoe_3159	2.948e-63	227.0	COG2050@1|root,COG2050@2|Bacteria,2HMKZ@201174|Actinobacteria,4CSHW@84995|Rubrobacteria	84995|Rubrobacteria	Q	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_3
SRD2_k127_1027075_2	555079.Toce_2128	5.08e-184	597.0	COG0480@1|root,COG0480@2|Bacteria,1TPWN@1239|Firmicutes,247N4@186801|Clostridia,42FPS@68295|Thermoanaerobacterales	186801|Clostridia	J	TIGRFAM Translation elongation factor	fusA2	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
SRD2_k127_1027075_17	326424.FRAAL6396	3.778e-42	164.0	COG0303@1|root,COG0303@2|Bacteria,2GJC3@201174|Actinobacteria,4ERWC@85013|Frankiales	201174|Actinobacteria	H	MoeA domain protein domain I and II	moeA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0071944,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.10.1.1,2.7.7.9	ko:K00963,ko:K03750	ko00040,ko00052,ko00500,ko00520,ko00790,ko01100,ko01130,map00040,map00052,map00500,map00520,map00790,map01100,map01130	M00129,M00361,M00362,M00549	R00289,R09735	RC00002,RC03462	ko00000,ko00001,ko00002,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
SRD2_k127_1027075_16	309801.trd_0544	4.979e-47	184.0	COG1316@1|root,COG1316@2|Bacteria,2G6PZ@200795|Chloroflexi,27XRZ@189775|Thermomicrobia	189775|Thermomicrobia	K	cell envelope-related transcriptional attenuator	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
SRD2_k127_1027075_12	266117.Rxyl_2862	1.352e-72	259.0	COG0006@1|root,COG0006@2|Bacteria,2GM7D@201174|Actinobacteria,4CSW8@84995|Rubrobacteria	84995|Rubrobacteria	E	Belongs to the peptidase M24B family	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
SRD2_k127_1027075_21	1380394.JADL01000002_gene1597	1.355e-32	135.0	COG0053@1|root,COG0053@2|Bacteria,1ND3V@1224|Proteobacteria,2U3WH@28211|Alphaproteobacteria,2JWFJ@204441|Rhodospirillales	204441|Rhodospirillales	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
SRD2_k127_1027075_19	415426.Hbut_0632	2.344e-35	143.0	COG2518@1|root,arCOG00976@2157|Archaea,2XPYU@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
SRD2_k127_1027075_1	247156.NFA_47480	4.381e-211	669.0	COG1012@1|root,COG1012@2|Bacteria,2GJZE@201174|Actinobacteria,4FU9P@85025|Nocardiaceae	201174|Actinobacteria	C	Aldehyde dehydrogenase family	pruA	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
SRD2_k127_1027075_3	710686.Mycsm_05090	2.035e-143	466.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,23617@1762|Mycobacteriaceae	201174|Actinobacteria	I	Belongs to the thiolase family	fadA3	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003988,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005777,GO:0005782,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0031907,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032787,GO:0034440,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0055114,GO:0070013,GO:0071704,GO:0072329,GO:0097159,GO:1901363,GO:1901575	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
SRD2_k127_1027075_11	1121017.AUFG01000006_gene1134	2.172e-75	263.0	COG0122@1|root,COG0122@2|Bacteria,2GP69@201174|Actinobacteria,4FEKE@85021|Intrasporangiaceae	201174|Actinobacteria	L	3-methyladenine DNA glycosylase	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_1027075_29	1292034.OR37_03680	3.841e-21	97.0	2DPVY@1|root,333MG@2|Bacteria,1NPT0@1224|Proteobacteria,2UKR4@28211|Alphaproteobacteria,2KHI2@204458|Caulobacterales	204458|Caulobacterales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3052
SRD2_k127_1027075_4	1150599.MPHLEI_04163	2.807e-141	458.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,23617@1762|Mycobacteriaceae	201174|Actinobacteria	I	Belongs to the thiolase family	fadA3	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003988,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005777,GO:0005782,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0031907,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032787,GO:0034440,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0055114,GO:0070013,GO:0071704,GO:0072329,GO:0097159,GO:1901363,GO:1901575	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
SRD2_k127_1037767_2	485913.Krac_10643	2.999e-34	149.0	COG1376@1|root,COG1376@2|Bacteria,2G6ZY@200795|Chloroflexi	200795|Chloroflexi	M	PFAM ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	LysM,YkuD
SRD2_k127_1037767_0	1464048.JNZS01000027_gene1873	3.433e-85	300.0	COG4177@1|root,COG4177@2|Bacteria,2GMGD@201174|Actinobacteria,4D9XN@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
SRD2_k127_1037767_1	1157637.KB892092_gene6927	6.482e-84	285.0	COG0559@1|root,COG0559@2|Bacteria,2HDZ9@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
SRD2_k127_1052443_1	504728.K649_10660	2.271e-24	111.0	COG4177@1|root,COG4177@2|Bacteria,1WJ7X@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	branched-chain amino acid transport system, permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
SRD2_k127_1052443_0	463191.SSEG_01320	6.633e-25	117.0	COG0411@1|root,COG0559@1|root,COG4177@1|root,COG0411@2|Bacteria,COG0559@2|Bacteria,COG4177@2|Bacteria,2GJHR@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	3.6.3.25	ko:K06020	-	-	-	-	ko00000,ko01000	-	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
SRD2_k127_1052443_2	1048339.KB913029_gene2399	6.45e-09	68.0	COG0683@1|root,COG0683@2|Bacteria	2|Bacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
SRD2_k127_1052443_3	926550.CLDAP_07830	8.166e-05	55.0	COG4447@1|root,COG4447@2|Bacteria,2G66V@200795|Chloroflexi	200795|Chloroflexi	G	glycosyl hydrolase, BNR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
SRD2_k127_1072719_2	1463879.JOHP01000001_gene1481	1.859e-152	492.0	COG4948@1|root,COG4948@2|Bacteria,2GJJR@201174|Actinobacteria	201174|Actinobacteria	M	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	menC	-	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
SRD2_k127_1072719_6	1128421.JAGA01000002_gene1079	8.025e-61	225.0	COG2355@1|root,COG2355@2|Bacteria	2|Bacteria	E	Zn-dependent dipeptidase, microsomal dipeptidase	pvdM	-	3.4.13.19	ko:K01273,ko:K01274	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
SRD2_k127_1072719_4	1068978.AMETH_3896	3.81e-105	364.0	COG2508@1|root,COG2508@2|Bacteria,2HNK1@201174|Actinobacteria,4DZXE@85010|Pseudonocardiales	201174|Actinobacteria	QT	PucR C-terminal helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_30
SRD2_k127_1072719_5	882083.SacmaDRAFT_3110	2.716e-62	226.0	COG3375@1|root,COG3375@2|Bacteria,2I8MV@201174|Actinobacteria,4DZFG@85010|Pseudonocardiales	201174|Actinobacteria	M	Mandelate Racemase Muconate Lactonizing	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
SRD2_k127_1072719_8	1449976.KALB_1314	6.439e-13	77.0	COG1309@1|root,COG1309@2|Bacteria,2IJTC@201174|Actinobacteria,4EBE4@85010|Pseudonocardiales	201174|Actinobacteria	K	BetI-type transcriptional repressor, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
SRD2_k127_1072719_3	926560.KE387027_gene366	8.297e-119	397.0	COG1680@1|root,COG1680@2|Bacteria,1WJK2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SRD2_k127_1072719_0	298655.KI912266_gene6362	4.461e-260	833.0	COG0411@1|root,COG0411@2|Bacteria,2H3P9@201174|Actinobacteria,4EXEI@85013|Frankiales	201174|Actinobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
SRD2_k127_1072719_1	298655.KI912266_gene6363	5.995e-165	546.0	COG0410@1|root,COG0410@2|Bacteria,2IH81@201174|Actinobacteria	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,MFS_1
SRD2_k127_1072719_7	1121946.AUAX01000007_gene2845	5.957e-46	190.0	COG0683@1|root,COG0683@2|Bacteria,2HZXR@201174|Actinobacteria,4D9W2@85008|Micromonosporales	201174|Actinobacteria	E	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
SRD2_k127_1093376_10	1123229.AUBC01000007_gene128	3.041e-32	136.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2VF27@28211|Alphaproteobacteria,3K6DU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
SRD2_k127_1093376_3	479434.Sthe_2535	5.625e-80	284.0	COG1473@1|root,COG1473@2|Bacteria,2G5WT@200795|Chloroflexi,27XWM@189775|Thermomicrobia	200795|Chloroflexi	S	Peptidase dimerisation domain	-	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
SRD2_k127_1093376_8	557599.MKAN_02115	1.634e-48	199.0	COG1073@1|root,COG1073@2|Bacteria,2IASV@201174|Actinobacteria,2333V@1762|Mycobacteriaceae	201174|Actinobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase,Peptidase_S9
SRD2_k127_1093376_0	1168065.DOK_00445	2.13e-256	820.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,1RMPX@1236|Gammaproteobacteria,1J99J@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	COG2366 Protein related to penicillin acylase	pvdQ	-	3.5.1.97	ko:K07116	-	-	-	-	ko00000,ko01000	-	-	-	Penicil_amidase
SRD2_k127_1093376_11	485913.Krac_10254	4.231e-24	116.0	COG0628@1|root,COG0628@2|Bacteria,2G6TV@200795|Chloroflexi	200795|Chloroflexi	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
SRD2_k127_1093376_6	1382359.JIAL01000001_gene469	2.355e-61	217.0	COG0225@1|root,COG0225@2|Bacteria,3Y4DM@57723|Acidobacteria,2JJ10@204432|Acidobacteriia	204432|Acidobacteriia	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	-	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
SRD2_k127_1093376_9	68170.KL590511_gene2984	1.597e-46	174.0	COG3576@1|root,COG3576@2|Bacteria,2I46F@201174|Actinobacteria,4EDRQ@85010|Pseudonocardiales	201174|Actinobacteria	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
SRD2_k127_1093376_12	530564.Psta_3892	4.889e-21	97.0	COG1917@1|root,COG1917@2|Bacteria,2J134@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Cupin 2 conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SRD2_k127_1093376_4	309801.trd_0548	1.121e-79	280.0	COG0842@1|root,COG0842@2|Bacteria,2G6H9@200795|Chloroflexi,27Y1P@189775|Thermomicrobia	189775|Thermomicrobia	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
SRD2_k127_1093376_2	264732.Moth_2297	1.477e-116	383.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia,42FFS@68295|Thermoanaerobacterales	186801|Clostridia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990,ko:K11050	ko02010,map02010	M00254,M00298	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.130	-	-	ABC_tran,DUF4162
SRD2_k127_1093376_13	234267.Acid_1148	8.303e-20	105.0	COG4099@1|root,COG4099@2|Bacteria,3Y5YX@57723|Acidobacteria	57723|Acidobacteria	S	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
SRD2_k127_1093376_5	526225.Gobs_3758	6.93e-64	228.0	COG2070@1|root,COG2070@2|Bacteria,2IN9Q@201174|Actinobacteria,4EX7F@85013|Frankiales	201174|Actinobacteria	S	Nitronate monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
SRD2_k127_1093376_1	1114959.SZMC14600_07382	1.367e-131	444.0	COG0210@1|root,COG0210@2|Bacteria,2GKRW@201174|Actinobacteria,4DXMZ@85010|Pseudonocardiales	201174|Actinobacteria	L	helicase	uvrD2	GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0006996,GO:0008094,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0040007,GO:0042623,GO:0043167,GO:0043169,GO:0046872,GO:0051276,GO:0071103,GO:0071840,GO:0140097	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HRDC,UvrD-helicase,UvrD_C
SRD2_k127_1093376_7	1169161.KB897740_gene2227	3.156e-52	186.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
SRD2_k127_1123999_2	485913.Krac_5100	3.962e-28	117.0	COG0412@1|root,COG0412@2|Bacteria	2|Bacteria	Q	carboxymethylenebutenolidase activity	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
SRD2_k127_1123999_3	103733.JNYO01000002_gene588	7e-18	93.0	COG1670@1|root,COG1670@2|Bacteria,2IIWF@201174|Actinobacteria,4E41X@85010|Pseudonocardiales	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_3
SRD2_k127_1123999_0	1128421.JAGA01000002_gene433	9.688e-58	215.0	COG5282@1|root,COG5282@2|Bacteria,2NQS2@2323|unclassified Bacteria	2|Bacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_2
SRD2_k127_1123999_1	298655.KI912266_gene5070	9.689e-40	154.0	COG1403@1|root,COG1403@2|Bacteria,2GU7G@201174|Actinobacteria,4EV73@85013|Frankiales	201174|Actinobacteria	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
SRD2_k127_1126359_16	749927.AMED_5391	3.181e-12	70.0	COG3170@1|root,COG3209@1|root,COG3170@2|Bacteria,COG3209@2|Bacteria,2GMBB@201174|Actinobacteria,4E3ST@85010|Pseudonocardiales	201174|Actinobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat,TIG
SRD2_k127_1126359_15	749927.AMED_5391	6.159e-13	76.0	COG3170@1|root,COG3209@1|root,COG3170@2|Bacteria,COG3209@2|Bacteria,2GMBB@201174|Actinobacteria,4E3ST@85010|Pseudonocardiales	201174|Actinobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat,TIG
SRD2_k127_1126359_18	591001.Acfer_1773	1.565e-07	65.0	COG3210@1|root,COG3210@2|Bacteria,1UUU4@1239|Firmicutes,4H21D@909932|Negativicutes	909932|Negativicutes	U	COG3210 Large exoproteins involved in heme utilization or adhesion	-	-	-	ko:K15125	ko05133,map05133	-	-	-	ko00000,ko00001,ko00536	-	-	-	DUF637,Fil_haemagg,Fil_haemagg_2,Haemagg_act
SRD2_k127_1126359_2	1449355.JQNR01000005_gene3890	2.58e-126	434.0	COG0741@1|root,COG3209@1|root,COG0741@2|Bacteria,COG3209@2|Bacteria,2GMBB@201174|Actinobacteria	201174|Actinobacteria	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
SRD2_k127_1126359_8	639030.JHVA01000001_gene2973	1.285e-42	163.0	COG0286@1|root,COG0286@2|Bacteria,3Y72C@57723|Acidobacteria,2JKH8@204432|Acidobacteriia	204432|Acidobacteriia	V	HsdM N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	HsdM_N,N6_Mtase
SRD2_k127_1126359_9	387631.Asulf_01536	1.1e-41	169.0	COG2856@1|root,arCOG07475@2157|Archaea,2Y0TB@28890|Euryarchaeota	28890|Euryarchaeota	K	IrrE N-terminal-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M78
SRD2_k127_1126359_3	1179773.BN6_34280	7.509e-108	395.0	COG3209@1|root,COG3209@2|Bacteria,2GMBB@201174|Actinobacteria,4EAK6@85010|Pseudonocardiales	201174|Actinobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
SRD2_k127_1126359_17	365528.KB891137_gene379	6.897e-11	77.0	COG1361@1|root,COG4625@1|root,COG4719@1|root,COG1361@2|Bacteria,COG4625@2|Bacteria,COG4719@2|Bacteria,2I8F1@201174|Actinobacteria	201174|Actinobacteria	M	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,He_PIG,fn3
SRD2_k127_1126359_5	1242864.D187_001045	3.501e-75	289.0	COG5184@1|root,COG5184@2|Bacteria,1R504@1224|Proteobacteria,42QHC@68525|delta/epsilon subdivisions,2WKUI@28221|Deltaproteobacteria,2YU2V@29|Myxococcales	28221|Deltaproteobacteria	DZ	Alpha-tubulin suppressor and related RCC1 domain-containing	-	-	-	-	-	-	-	-	-	-	-	-	RCC1
SRD2_k127_1126359_7	222534.KB893761_gene3562	2.951e-51	194.0	COG0582@1|root,COG0582@2|Bacteria,2GMMI@201174|Actinobacteria,4EU5A@85013|Frankiales	201174|Actinobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_4,Phage_int_SAM_3,Phage_integrase
SRD2_k127_1126359_14	1122927.KB895435_gene518	6.129e-19	95.0	COG0582@1|root,COG0582@2|Bacteria,1TTJI@1239|Firmicutes,4HDG6@91061|Bacilli,274R3@186822|Paenibacillaceae	91061|Bacilli	L	Arm DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_4,Phage_int_SAM_3,Phage_int_SAM_5,Phage_integrase
SRD2_k127_1126359_21	1403313.AXBR01000014_gene2203	4.165e-05	46.0	2EG8N@1|root,33A0G@2|Bacteria,1VMHK@1239|Firmicutes,4HSIH@91061|Bacilli,1ZJWT@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_1126359_22	748727.CLJU_c18020	0.0007727	50.0	COG3103@1|root,COG4991@2|Bacteria,1VBMC@1239|Firmicutes,24CJ7@186801|Clostridia,36HBQ@31979|Clostridiaceae	186801|Clostridia	T	cell wall binding repeat	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
SRD2_k127_1126359_13	979556.MTES_3394	3.53e-20	103.0	2ETGF@1|root,33M0A@2|Bacteria,2ISKX@201174|Actinobacteria,4FPWH@85023|Microbacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_1126359_1	446466.Cfla_1419	1.388e-198	673.0	COG1674@1|root,COG1716@1|root,COG1674@2|Bacteria,COG1716@2|Bacteria,2GJBR@201174|Actinobacteria,4F0IN@85016|Cellulomonadaceae	201174|Actinobacteria	D	PFAM cell divisionFtsK SpoIIIE	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_SpoIIIE,Yop-YscD_cpl
SRD2_k127_1126359_4	562970.Btus_2561	1.109e-84	291.0	COG1250@1|root,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,4HA59@91061|Bacilli,279C1@186823|Alicyclobacillaceae	91061|Bacilli	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
SRD2_k127_1126359_6	1227739.Hsw_3882	9.532e-64	235.0	COG0697@1|root,COG0697@2|Bacteria,4NGJR@976|Bacteroidetes,47N5J@768503|Cytophagia	976|Bacteroidetes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SRD2_k127_1126359_12	1408254.T458_10975	1.169e-24	116.0	COG2227@1|root,COG2227@2|Bacteria,1UHU9@1239|Firmicutes,4HFRY@91061|Bacilli,277EV@186822|Paenibacillaceae	91061|Bacilli	H	Methyltransferase small domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
SRD2_k127_1126359_20	931627.MycrhDRAFT_3384	1.166e-05	57.0	2FIJ7@1|root,34AB9@2|Bacteria,2GUPT@201174|Actinobacteria,23ESG@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_1126359_10	644966.Tmar_1516	1.053e-29	126.0	COG3255@1|root,COG3255@2|Bacteria,1V7IH@1239|Firmicutes	1239|Firmicutes	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
SRD2_k127_1126359_11	675635.Psed_3392	7.719e-27	126.0	COG2114@1|root,COG2114@2|Bacteria,2GN02@201174|Actinobacteria,4E1TB@85010|Pseudonocardiales	201174|Actinobacteria	T	Adenylate cyclase regulatory domain	cya	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Ad_Cy_reg,Guanylate_cyc
SRD2_k127_1126359_0	479434.Sthe_2381	1.553e-248	783.0	COG0365@1|root,COG0365@2|Bacteria,2G830@200795|Chloroflexi,27XH3@189775|Thermomicrobia	189775|Thermomicrobia	I	Acetyl-coenzyme A synthetase N-terminus	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
SRD2_k127_1132833_2	622637.KE124774_gene1497	5.511e-15	79.0	COG3385@1|root,COG3385@2|Bacteria,1QURV@1224|Proteobacteria,2TW56@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2183 Transcriptional accessory protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
SRD2_k127_1132833_0	886293.Sinac_0622	3.078e-220	687.0	COG5433@1|root,COG5433@2|Bacteria,2J24J@203682|Planctomycetes	203682|Planctomycetes	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
SRD2_k127_1132833_1	991905.SL003B_4075	2.514e-48	185.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria	1224|Proteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_38,HTH_7,rve
SRD2_k127_1132833_3	1123229.AUBC01000040_gene3836	1.024e-05	57.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TS16@28211|Alphaproteobacteria,3JSGF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
SRD2_k127_1145432_0	643648.Slip_1163	4.231e-69	250.0	COG1615@1|root,COG1615@2|Bacteria,1TQHM@1239|Firmicutes,248PM@186801|Clostridia,42JMJ@68298|Syntrophomonadaceae	186801|Clostridia	S	Uncharacterised protein family (UPF0182)	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
SRD2_k127_1148009_3	1313301.AUGC01000013_gene1249	4.308e-105	363.0	COG3246@1|root,COG3246@2|Bacteria,4NGNQ@976|Bacteroidetes	976|Bacteroidetes	S	3-keto-5-aminohexanoate cleavage protein	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
SRD2_k127_1148009_5	744872.Spica_2365	3.135e-57	208.0	COG2227@1|root,COG2227@2|Bacteria,2J59U@203691|Spirochaetes	203691|Spirochaetes	H	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
SRD2_k127_1148009_1	68194.JNXR01000015_gene7990	2.835e-159	520.0	COG1716@1|root,COG1994@1|root,COG1716@2|Bacteria,COG1994@2|Bacteria,2IBWH@201174|Actinobacteria	201174|Actinobacteria	O	Peptidase M50	-	-	-	ko:K16922	-	-	-	-	ko00000,ko01002	-	-	-	AhpC-TSA,FHA,Yop-YscD_cpl,cNMP_binding
SRD2_k127_1148009_4	1172179.AUKV01000005_gene5726	7.222e-79	276.0	COG2267@1|root,COG2267@2|Bacteria,2I4WD@201174|Actinobacteria	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
SRD2_k127_1148009_6	1121439.dsat_2427	8.979e-15	81.0	COG1595@1|root,COG1595@2|Bacteria,1PEZT@1224|Proteobacteria,42W2J@68525|delta/epsilon subdivisions,2WS5K@28221|Deltaproteobacteria,2MGGB@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SRD2_k127_1148009_7	591158.SSMG_03379	2.462e-08	64.0	COG3794@1|root,COG3794@2|Bacteria,2IQAI@201174|Actinobacteria	201174|Actinobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
SRD2_k127_1148009_0	1283299.AUKG01000001_gene2768	1.333e-195	626.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4CS0R@84995|Rubrobacteria	84995|Rubrobacteria	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
SRD2_k127_1148009_2	997346.HMPREF9374_1048	1.076e-134	442.0	COG0439@1|root,COG0439@2|Bacteria,1TP16@1239|Firmicutes,4HA40@91061|Bacilli,27BNC@186824|Thermoactinomycetaceae	91061|Bacilli	I	Biotin carboxylase C-terminal domain	accA1	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
SRD2_k127_1148009_8	1313172.YM304_37480	3.328e-05	55.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
SRD2_k127_1168652_2	273075.Ta0200	1.119e-26	114.0	COG2151@1|root,arCOG01845@2157|Archaea,2Y0P6@28890|Euryarchaeota,242AR@183967|Thermoplasmata	183967|Thermoplasmata	S	Pfam:DUF59	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
SRD2_k127_1168652_1	1313172.YM304_14810	1.466e-38	151.0	COG0822@1|root,COG0822@2|Bacteria,2IHY9@201174|Actinobacteria,4CN20@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NifU-like N terminal domain	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
SRD2_k127_1168652_0	1382304.JNIL01000001_gene3219	1.428e-146	473.0	COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,4HA6Z@91061|Bacilli,27802@186823|Alicyclobacillaceae	91061|Bacilli	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
SRD2_k127_1193562_3	1337936.IJ00_26680	2.503e-19	92.0	COG0204@1|root,COG0204@2|Bacteria,1G1AK@1117|Cyanobacteria,1HMFN@1161|Nostocales	1117|Cyanobacteria	I	PFAM Phospholipid glycerol acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
SRD2_k127_1193562_4	926560.KE387023_gene2290	8.779e-05	49.0	COG2329@1|root,COG2329@2|Bacteria,1WNAU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
SRD2_k127_1193562_1	1214101.BN159_8012	7.974e-49	186.0	COG2230@1|root,COG2230@2|Bacteria	2|Bacteria	M	cyclopropane-fatty-acyl-phospholipid synthase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS,Methyltransf_25
SRD2_k127_1193562_0	1463926.JOCA01000002_gene5636	1.821e-59	219.0	COG1985@1|root,COG1985@2|Bacteria	2|Bacteria	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K00082,ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C
SRD2_k127_1193562_2	1463900.JOIX01000041_gene1984	8.543e-38	143.0	COG0302@1|root,COG0302@2|Bacteria,2H2JE@201174|Actinobacteria	201174|Actinobacteria	H	GTP cyclohydrolase I	-	-	-	-	-	-	-	-	-	-	-	-	GTP_cyclohydroI
SRD2_k127_1213824_36	1120973.AQXL01000117_gene362	1.744e-08	64.0	COG0683@1|root,COG0683@2|Bacteria,1V1GS@1239|Firmicutes,4HK5N@91061|Bacilli,279XK@186823|Alicyclobacillaceae	91061|Bacilli	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
SRD2_k127_1213824_29	1000565.METUNv1_03273	7.657e-23	111.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2VJAS@28216|Betaproteobacteria,2KUUP@206389|Rhodocyclales	206389|Rhodocyclales	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
SRD2_k127_1213824_15	1123023.JIAI01000002_gene5056	1.049e-64	253.0	COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,2GMEE@201174|Actinobacteria,4E494@85010|Pseudonocardiales	201174|Actinobacteria	P	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
SRD2_k127_1213824_5	485913.Krac_2372	1.067e-100	341.0	2DBVK@1|root,2ZBBH@2|Bacteria,2G7SF@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_1213824_16	93220.LV28_02540	1.182e-62	245.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2VIWI@28216|Betaproteobacteria,1K590@119060|Burkholderiaceae	28216|Betaproteobacteria	S	penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
SRD2_k127_1213824_32	485913.Krac_7599	2.809e-18	87.0	COG1254@1|root,COG1254@2|Bacteria,2G728@200795|Chloroflexi	200795|Chloroflexi	C	Belongs to the acylphosphatase family	-	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
SRD2_k127_1213824_3	134676.ACPL_4190	2.151e-115	383.0	COG2197@1|root,COG2267@1|root,COG2197@2|Bacteria,COG2267@2|Bacteria,2GN4Z@201174|Actinobacteria,4DIF8@85008|Micromonosporales	201174|Actinobacteria	K	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,GerE
SRD2_k127_1213824_11	1121946.AUAX01000017_gene5028	1.468e-80	276.0	COG2020@1|root,COG2020@2|Bacteria,2GN9N@201174|Actinobacteria,4DDTM@85008|Micromonosporales	201174|Actinobacteria	O	NnrU protein	-	-	2.1.1.334	ko:K21310	ko00920,map00920	-	R11546	RC02653	ko00000,ko00001,ko01000	-	-	-	NnrU
SRD2_k127_1213824_4	219305.MCAG_00216	6.476e-103	352.0	COG2303@1|root,COG2303@2|Bacteria,2GJAU@201174|Actinobacteria,4DHA3@85008|Micromonosporales	201174|Actinobacteria	E	GMC oxidoreductase	-	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
SRD2_k127_1213824_23	1192034.CAP_3828	5.586e-39	154.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	mshD	-	2.3.1.189	ko:K15520	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_3
SRD2_k127_1213824_10	1156844.KB891798_gene6150	1.374e-85	302.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
SRD2_k127_1213824_12	521098.Aaci_0345	1.883e-73	262.0	COG1686@1|root,COG1686@2|Bacteria,1VZJP@1239|Firmicutes	1239|Firmicutes	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
SRD2_k127_1213824_19	867845.KI911784_gene2238	1.33e-46	172.0	COG1490@1|root,COG1490@2|Bacteria,2G6P5@200795|Chloroflexi,3778M@32061|Chloroflexia	32061|Chloroflexia	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
SRD2_k127_1213824_7	926550.CLDAP_37440	1.814e-95	340.0	COG0744@1|root,COG0744@2|Bacteria,2G5ZG@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase, family 51	-	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
SRD2_k127_1213824_40	1380390.JIAT01000010_gene4752	2.293e-06	52.0	2DNW5@1|root,32ZGI@2|Bacteria,2IQ5T@201174|Actinobacteria,4CT8N@84995|Rubrobacteria	84995|Rubrobacteria	S	Rho termination factor, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Rho_N
SRD2_k127_1213824_9	1313172.YM304_42510	1.467e-92	311.0	COG0300@1|root,COG0300@2|Bacteria,2IIVW@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SRD2_k127_1213824_39	1283300.ATXB01000002_gene2728	4.419e-07	63.0	COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1RYYR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,GAF_2,GGDEF,PAS_3,PAS_4,PAS_8,PocR
SRD2_k127_1213824_20	118163.Ple7327_3130	1.081e-45	181.0	COG2267@1|root,COG2267@2|Bacteria,1G2EN@1117|Cyanobacteria,3VIY7@52604|Pleurocapsales	1117|Cyanobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
SRD2_k127_1213824_17	330084.JNYZ01000022_gene3759	1.641e-57	226.0	COG3451@1|root,COG3451@2|Bacteria,2GM5W@201174|Actinobacteria,4E1I0@85010|Pseudonocardiales	201174|Actinobacteria	U	Type IV secretory pathway, VirB4	-	-	-	-	-	-	-	-	-	-	-	-	AAA_10,DUF87,PrgI
SRD2_k127_1213824_31	1229203.KI301992_gene455	3.725e-19	100.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
SRD2_k127_1213824_6	1120950.KB892731_gene3871	2.582e-96	341.0	COG2936@1|root,COG2936@2|Bacteria,2I357@201174|Actinobacteria,4DSBH@85009|Propionibacteriales	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	PepX_C,Peptidase_S15
SRD2_k127_1213824_1	405948.SACE_7106	2.855e-128	416.0	COG2897@1|root,COG2897@2|Bacteria,2GIYU@201174|Actinobacteria,4E0UA@85010|Pseudonocardiales	201174|Actinobacteria	P	Sulfurtransferase	cysA2	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
SRD2_k127_1213824_33	585531.HMPREF0063_11469	3.556e-14	76.0	2E36U@1|root,32Y6I@2|Bacteria,2IM2G@201174|Actinobacteria,4DRR8@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF1416)	sseC	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF1416
SRD2_k127_1213824_30	443218.AS9A_1484	2.207e-20	99.0	COG3571@1|root,COG3571@2|Bacteria,2GKKE@201174|Actinobacteria,234V8@1762|Mycobacteriaceae	201174|Actinobacteria	S	hydrolase of the alpha beta-hydrolase fold	-	-	-	ko:K07020	-	-	-	-	ko00000	-	-	-	DLH
SRD2_k127_1213824_41	1121920.AUAU01000021_gene2530	2.58e-06	60.0	COG0823@1|root,COG0823@2|Bacteria,3Y2RC@57723|Acidobacteria	57723|Acidobacteria	U	WD40-like Beta Propeller	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
SRD2_k127_1213824_37	443143.GM18_3184	2.283e-08	67.0	COG5276@1|root,COG5276@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347,LVIVD
SRD2_k127_1213824_34	1232410.KI421415_gene3007	1.421e-11	77.0	2B9FT@1|root,322TS@2|Bacteria,1RKUJ@1224|Proteobacteria,42SNA@68525|delta/epsilon subdivisions,2WPES@28221|Deltaproteobacteria,43SKX@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_1213824_26	1121428.DESHY_80044___1	8.142e-34	143.0	COG0406@1|root,COG0406@2|Bacteria,1V6ES@1239|Firmicutes,24JDV@186801|Clostridia,261XP@186807|Peptococcaceae	186801|Clostridia	G	Belongs to the phosphoglycerate mutase family	pspA	-	3.1.3.3,3.1.3.73	ko:K02226,ko:K22305	ko00260,ko00680,ko00860,ko01100,ko01120,ko01130,map00260,map00680,map00860,map01100,map01120,map01130	M00122	R00582,R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
SRD2_k127_1213824_18	573413.Spirs_2888	1.602e-50	200.0	COG2348@1|root,COG2348@2|Bacteria,2J58H@203691|Spirochaetes	203691|Spirochaetes	V	Methicillin resistance protein	femA	-	-	-	-	-	-	-	-	-	-	-	FemAB
SRD2_k127_1213824_21	234267.Acid_7838	1.277e-45	179.0	COG4252@1|root,COG5002@1|root,COG4252@2|Bacteria,COG5002@2|Bacteria,3Y7KI@57723|Acidobacteria	57723|Acidobacteria	T	CHASE2	-	-	-	-	-	-	-	-	-	-	-	-	CHASE2,HATPase_c,HisKA
SRD2_k127_1213824_14	697303.Thewi_1591	2.559e-67	237.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,42JDU@68295|Thermoanaerobacterales	186801|Clostridia	K	Response regulator receiver	phoP	-	-	ko:K02483,ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SRD2_k127_1213824_25	472759.Nhal_0111	7.337e-37	152.0	2CCJR@1|root,2ZCU4@2|Bacteria,1RC7F@1224|Proteobacteria,1S3JC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_1213824_27	525904.Tter_0605	1.521e-29	132.0	COG2320@1|root,COG2320@2|Bacteria,2NPV4@2323|unclassified Bacteria	2|Bacteria	S	GrpB protein	-	-	-	-	-	-	-	-	-	-	-	-	GrpB
SRD2_k127_1213824_28	1121033.AUCF01000017_gene3749	5.525e-28	127.0	COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,2U8D6@28211|Alphaproteobacteria,2JTRD@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	-	-	2.7.6.3,4.1.2.25	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R03504	RC00002,RC00017,RC00721,RC00943	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB,HPPK
SRD2_k127_1213824_8	1121468.AUBR01000008_gene2055	8.288e-95	317.0	COG0294@1|root,COG0294@2|Bacteria,1TPKT@1239|Firmicutes,248BE@186801|Clostridia,42FAT@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS03115	Pterin_bind
SRD2_k127_1213824_2	357808.RoseRS_0794	4.845e-128	426.0	COG0769@1|root,COG0769@2|Bacteria,2G5U3@200795|Chloroflexi,375DT@32061|Chloroflexia	32061|Chloroflexia	M	Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
SRD2_k127_1213824_35	316274.Haur_0977	1.455e-08	66.0	COG0823@1|root,COG0823@2|Bacteria,2G8PZ@200795|Chloroflexi,377MH@32061|Chloroflexia	32061|Chloroflexia	U	WD40 domain protein beta Propeller	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
SRD2_k127_1213824_24	1121428.DESHY_30013___1	8.768e-38	154.0	COG0357@1|root,COG0357@2|Bacteria,1TPBT@1239|Firmicutes,247WM@186801|Clostridia,261UV@186807|Peptococcaceae	186801|Clostridia	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
SRD2_k127_1213824_38	197221.22293800	5.413e-08	67.0	2E7Q2@1|root,3325J@2|Bacteria,1G91H@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function (DUF2752)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2752
SRD2_k127_1213824_0	292459.STH1810	3.958e-132	439.0	COG0019@1|root,COG0019@2|Bacteria,1TPE9@1239|Firmicutes,247X7@186801|Clostridia	186801|Clostridia	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS18870	Orn_Arg_deC_N,Orn_DAP_Arg_deC
SRD2_k127_1213824_22	292459.STH607	1.583e-41	168.0	COG0577@1|root,COG0577@2|Bacteria,1TUYK@1239|Firmicutes,24DGM@186801|Clostridia	186801|Clostridia	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SRD2_k127_1213824_13	1094980.Mpsy_1277	3.144e-68	241.0	COG1136@1|root,arCOG00922@2157|Archaea,2Y33K@28890|Euryarchaeota,2NAC3@224756|Methanomicrobia	224756|Methanomicrobia	V	Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
SRD2_k127_1223499_4	656024.FsymDg_4132	4.776e-24	106.0	COG0303@1|root,COG0303@2|Bacteria,2GJC3@201174|Actinobacteria,4ERWC@85013|Frankiales	201174|Actinobacteria	H	MoeA domain protein domain I and II	moeA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0071944,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.10.1.1,2.7.7.9	ko:K00963,ko:K03750	ko00040,ko00052,ko00500,ko00520,ko00790,ko01100,ko01130,map00040,map00052,map00500,map00520,map00790,map01100,map01130	M00129,M00361,M00362,M00549	R00289,R09735	RC00002,RC03462	ko00000,ko00001,ko00002,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
SRD2_k127_1223499_3	639030.JHVA01000001_gene1811	6.106e-41	168.0	COG0521@1|root,COG0521@2|Bacteria,3Y504@57723|Acidobacteria,2JJI8@204432|Acidobacteriia	204432|Acidobacteriia	H	Probable molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
SRD2_k127_1223499_1	326427.Cagg_0614	2.36e-79	276.0	COG2514@1|root,COG2514@2|Bacteria,2G6MQ@200795|Chloroflexi,375QT@32061|Chloroflexia	32061|Chloroflexia	C	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	1.13.11.2	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
SRD2_k127_1223499_2	1173026.Glo7428_2204	1.235e-53	193.0	COG0784@1|root,COG0784@2|Bacteria,1GQ4W@1117|Cyanobacteria	1117|Cyanobacteria	T	PFAM response regulator receiveR	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
SRD2_k127_1223499_0	591167.Sfla_4896	2.369e-102	337.0	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	drrA_2	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SRD2_k127_124610_0	485913.Krac_12284	2.417e-27	115.0	COG0849@1|root,COG0849@2|Bacteria	2|Bacteria	D	cell division	-	-	-	-	-	-	-	-	-	-	-	-	FtsA
SRD2_k127_124610_2	1382306.JNIM01000001_gene245	2.909e-09	70.0	COG3299@1|root,COG3299@2|Bacteria	2|Bacteria	S	Baseplate J-like protein	-	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	Baseplate_J,CBM_3,CBM_4_9,Calx-beta,F5_F8_type_C,GSDH,PA14,fn3
SRD2_k127_124610_1	1121861.KB899911_gene1414	4.129e-16	87.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,2U98Y@28211|Alphaproteobacteria,2JSP7@204441|Rhodospirillales	204441|Rhodospirillales	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
SRD2_k127_1249907_0	685727.REQ_15230	5.66e-220	717.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4FU7Y@85025|Nocardiaceae	201174|Actinobacteria	P	PFAM E1-E2 ATPase-associated domain protein, Haloacid dehalogenase domain protein hydrolase, cation transporting ATPase domain protein	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
SRD2_k127_1249907_5	710421.Mycch_2936	1.107e-104	349.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,23350@1762|Mycobacteriaceae	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SRD2_k127_1249907_7	710421.Mycch_2937	6.23e-96	334.0	COG3559@1|root,COG3559@2|Bacteria	2|Bacteria	M	Exporter of polyketide antibiotics	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
SRD2_k127_1249907_12	690850.Desaf_0566	3.771e-21	105.0	COG1266@1|root,COG1266@2|Bacteria,1PD7Q@1224|Proteobacteria,43322@68525|delta/epsilon subdivisions,2WXQ8@28221|Deltaproteobacteria,2MB8M@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM Abortive infection protein	-	-	-	-	-	-	-	-	-	-	-	-	Abi
SRD2_k127_1249907_14	1348663.KCH_00280	3.133e-15	81.0	COG2197@1|root,COG2197@2|Bacteria,2I33K@201174|Actinobacteria,2M384@2063|Kitasatospora	201174|Actinobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
SRD2_k127_1249907_13	235985.BBPN01000012_gene6816	1.637e-19	96.0	COG1595@1|root,COG1595@2|Bacteria,2GKDD@201174|Actinobacteria,2NIRK@228398|Streptacidiphilus	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SRD2_k127_1249907_6	1380390.JIAT01000009_gene1175	3.23e-98	328.0	COG1250@1|root,COG1250@2|Bacteria,2GJBM@201174|Actinobacteria,4CRAJ@84995|Rubrobacteria	84995|Rubrobacteria	I	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	3HCDH,3HCDH_N
SRD2_k127_1249907_11	309801.trd_A0658	5.246e-30	134.0	COG2133@1|root,COG2133@2|Bacteria,2G62S@200795|Chloroflexi,27Y3V@189775|Thermomicrobia	189775|Thermomicrobia	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
SRD2_k127_1249907_1	926560.KE387023_gene2049	8.708e-145	481.0	COG5001@1|root,COG5001@2|Bacteria,1WK20@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GAF_2,GGDEF,PAS,PAS_3,PAS_4
SRD2_k127_1249907_3	640132.Srot_3052	5.834e-117	383.0	COG2897@1|root,COG2897@2|Bacteria,2GIYU@201174|Actinobacteria	201174|Actinobacteria	P	sulfurtransferase	cysA2	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
SRD2_k127_1249907_16	351607.Acel_0060	0.0004455	46.0	2E36U@1|root,32Y6I@2|Bacteria,2IM2G@201174|Actinobacteria,4ETDN@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF1416)	sseC	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF1416
SRD2_k127_1249907_4	1048339.KB913029_gene2552	1.236e-105	372.0	COG3055@1|root,COG3055@2|Bacteria,2GK14@201174|Actinobacteria,4ESZ1@85013|Frankiales	201174|Actinobacteria	S	Domain of unknown function (DUF1929)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1929,Kelch_2
SRD2_k127_1249907_2	390989.JOEG01000010_gene561	8.052e-124	411.0	COG0477@1|root,COG2814@2|Bacteria,2I2IS@201174|Actinobacteria,4DCIJ@85008|Micromonosporales	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
SRD2_k127_1249907_8	215803.DB30_7088	6.802e-87	301.0	COG4260@1|root,COG4260@2|Bacteria,1MXTD@1224|Proteobacteria,42P7D@68525|delta/epsilon subdivisions,2WJ6S@28221|Deltaproteobacteria,2YUUH@29|Myxococcales	28221|Deltaproteobacteria	S	SPFH domain-Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DUF4339,DZR,SHOCT,zinc_ribbon_2
SRD2_k127_1249907_10	314230.DSM3645_18996	4.151e-32	143.0	COG4395@1|root,COG4395@2|Bacteria	2|Bacteria	S	Tim44	MA20_24770	-	-	ko:K15539	-	-	-	-	ko00000	-	-	-	Tim44
SRD2_k127_1249907_9	1051006.HMPREF1162_0014	9.925e-54	203.0	COG1192@1|root,COG1192@2|Bacteria,2GJX3@201174|Actinobacteria,4DP0V@85009|Propionibacteriales	201174|Actinobacteria	D	Cellulose biosynthesis protein BcsQ	soj	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009295,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0071944	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
SRD2_k127_1249907_15	702437.HMPREF9432_01177	5.198e-06	60.0	COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,4H2P0@909932|Negativicutes	909932|Negativicutes	K	Belongs to the ParB family	spo0J	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
SRD2_k127_1265498_1	1254432.SCE1572_36400	3.436e-39	159.0	COG1484@1|root,COG1484@2|Bacteria,1MVU2@1224|Proteobacteria,42PXQ@68525|delta/epsilon subdivisions,2WKHU@28221|Deltaproteobacteria,2YZ37@29|Myxococcales	28221|Deltaproteobacteria	L	COG1484 DNA replication protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
SRD2_k127_1265498_0	1121468.AUBR01000078_gene859	1.54e-67	250.0	COG4584@1|root,COG4584@2|Bacteria,1TR5X@1239|Firmicutes,25D02@186801|Clostridia,42FJ4@68295|Thermoanaerobacterales	186801|Clostridia	L	COGs COG4584 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,Mu-transpos_C,rve
SRD2_k127_1265498_3	699218.HMPREF0889_0651	9.561e-09	66.0	COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,4H2P0@909932|Negativicutes	909932|Negativicutes	K	Belongs to the ParB family	spo0J	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
SRD2_k127_1288595_2	321332.CYB_1605	2.269e-31	124.0	COG0154@1|root,COG0154@2|Bacteria,1G0HS@1117|Cyanobacteria,1GZCX@1129|Synechococcus	1117|Cyanobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
SRD2_k127_1288595_0	1121472.AQWN01000002_gene2283	2.196e-155	509.0	COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,247MS@186801|Clostridia,260XG@186807|Peptococcaceae	186801|Clostridia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
SRD2_k127_1288595_1	479434.Sthe_2682	1.2e-33	138.0	COG2265@1|root,COG2265@2|Bacteria,2G6IV@200795|Chloroflexi,27XG5@189775|Thermomicrobia	189775|Thermomicrobia	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	-	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
SRD2_k127_1318325_13	926569.ANT_19510	1.577e-28	133.0	COG0451@1|root,COG0451@2|Bacteria,2G74B@200795|Chloroflexi	200795|Chloroflexi	GM	Protein of unknown function (DUF4012)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4012
SRD2_k127_1318325_15	926569.ANT_23120	2.482e-05	55.0	COG3764@1|root,COG3764@2|Bacteria,2G98S@200795|Chloroflexi	200795|Chloroflexi	M	PFAM peptidase C60, sortase A and B	-	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
SRD2_k127_1318325_0	521098.Aaci_1798	5.113e-184	591.0	COG1003@1|root,COG1003@2|Bacteria,1TPK9@1239|Firmicutes,4HB80@91061|Bacilli,27881@186823|Alicyclobacillaceae	91061|Bacilli	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,GDC-P
SRD2_k127_1318325_1	358681.BBR47_22980	1.206e-115	403.0	COG0403@1|root,COG0403@2|Bacteria,1TQGG@1239|Firmicutes,4HA7P@91061|Bacilli,26RS0@186822|Paenibacillaceae	91061|Bacilli	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
SRD2_k127_1318325_9	264732.Moth_1944	8.003e-37	142.0	COG0509@1|root,COG0509@2|Bacteria,1V6WV@1239|Firmicutes,24N5H@186801|Clostridia,42GJZ@68295|Thermoanaerobacterales	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	-	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
SRD2_k127_1318325_2	404589.Anae109_2522	2.188e-101	344.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,42QM6@68525|delta/epsilon subdivisions,2WK2P@28221|Deltaproteobacteria,2YU3I@29|Myxococcales	28221|Deltaproteobacteria	H	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
SRD2_k127_1318325_7	56107.Cylst_0338	1.554e-43	176.0	COG4122@1|root,COG4122@2|Bacteria,1G64A@1117|Cyanobacteria	1117|Cyanobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
SRD2_k127_1318325_14	525909.Afer_1260	5.904e-06	56.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4CNRK@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Sigma-70 region 3	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
SRD2_k127_1318325_4	479434.Sthe_1855	4.399e-91	316.0	COG1030@1|root,COG1030@2|Bacteria,2G6E2@200795|Chloroflexi,27XU8@189775|Thermomicrobia	189775|Thermomicrobia	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
SRD2_k127_1318325_10	635013.TherJR_2843	5.29e-33	143.0	COG0297@1|root,COG0438@1|root,COG0297@2|Bacteria,COG0438@2|Bacteria,1UASH@1239|Firmicutes,248VW@186801|Clostridia,262C0@186807|Peptococcaceae	186801|Clostridia	M	PFAM Glycosyl	-	-	2.4.1.349	ko:K12994	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
SRD2_k127_1318325_3	485913.Krac_9806	1.484e-91	308.0	COG0330@1|root,COG0330@2|Bacteria,2G5SB@200795|Chloroflexi	200795|Chloroflexi	O	PFAM band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
SRD2_k127_1318325_12	1128421.JAGA01000003_gene3304	4.856e-29	130.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
SRD2_k127_1318325_5	264732.Moth_2516	1.675e-81	294.0	COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,2488C@186801|Clostridia,42F5R@68295|Thermoanaerobacterales	186801|Clostridia	D	PFAM Cobyrinic acid a,c-diamide synthase	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
SRD2_k127_1318325_6	926569.ANT_13970	1.573e-61	224.0	COG1475@1|root,COG1475@2|Bacteria,2G6EK@200795|Chloroflexi	200795|Chloroflexi	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
SRD2_k127_1318325_8	1288484.APCS01000075_gene2011	2.834e-38	147.0	2DZT4@1|root,32VI7@2|Bacteria,1WMUG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_1318325_11	639030.JHVA01000001_gene1173	1.14e-31	131.0	COG0681@1|root,COG0681@2|Bacteria,3Y49Z@57723|Acidobacteria,2JJ4I@204432|Acidobacteriia	204432|Acidobacteriia	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
SRD2_k127_1343892_1	1380390.JIAT01000009_gene976	4.358e-82	291.0	2DBGS@1|root,2Z95N@2|Bacteria,2ICPX@201174|Actinobacteria,4CRBV@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_1343892_0	1123242.JH636434_gene4803	1.152e-83	287.0	COG4221@1|root,COG4221@2|Bacteria	2|Bacteria	IQ	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SRD2_k127_1343892_2	710696.Intca_3211	8.476e-57	205.0	COG2030@1|root,COG2030@2|Bacteria,2IHRG@201174|Actinobacteria,4FH7U@85021|Intrasporangiaceae	201174|Actinobacteria	I	COG2030 Acyl dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
SRD2_k127_1343892_3	1117379.BABA_12101	4.759e-48	182.0	COG2267@1|root,COG2267@2|Bacteria,1UKWC@1239|Firmicutes,4ITKP@91061|Bacilli	91061|Bacilli	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
SRD2_k127_143815_2	1227360.C176_04038	2.576e-08	66.0	COG1714@1|root,COG1714@2|Bacteria,1VIH4@1239|Firmicutes,4HSGI@91061|Bacilli,26HVU@186818|Planococcaceae	91061|Bacilli	S	RDD family	yxaI	-	-	-	-	-	-	-	-	-	-	-	RDD
SRD2_k127_143815_0	1128421.JAGA01000003_gene3532	1.697e-62	225.0	COG5032@1|root,COG5032@2|Bacteria,2NR1S@2323|unclassified Bacteria	2|Bacteria	BDLTU	phosphatidylinositol kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	PI3_PI4_kinase
SRD2_k127_143815_1	765420.OSCT_0511	3.726e-26	112.0	298YA@1|root,2ZW25@2|Bacteria,2G6UQ@200795|Chloroflexi,375RV@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function (DUF3090)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3090
SRD2_k127_1440210_0	385682.AFSL01000040_gene227	8.571e-18	96.0	COG2801@1|root,COG3415@1|root,COG2801@2|Bacteria,COG3415@2|Bacteria	2|Bacteria	L	Transposase	-	-	2.7.7.4	ko:K00957,ko:K07497	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	HTH_23,HTH_29,PAPS_reduct,rve,rve_3
SRD2_k127_1440210_1	118173.KB235914_gene2112	6.437e-07	54.0	COG3676@1|root,COG3676@2|Bacteria	2|Bacteria	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
SRD2_k127_1457239_1	494419.ALPM01000004_gene1793	1.67e-41	161.0	COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria,1W8R7@1268|Micrococcaceae	201174|Actinobacteria	L	PFAM Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
SRD2_k127_1457239_0	494419.ALPM01000004_gene1793	1.192e-56	202.0	COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria,1W8R7@1268|Micrococcaceae	201174|Actinobacteria	L	PFAM Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
SRD2_k127_1457239_3	930171.Asphe3_30570	9.208e-17	88.0	COG3464@1|root,COG3464@2|Bacteria,2GJK7@201174|Actinobacteria,1WB05@1268|Micrococcaceae	201174|Actinobacteria	L	4.5 Transposon and IS	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
SRD2_k127_1457239_2	1305732.JAGG01000001_gene587	1.267e-18	97.0	COG3464@1|root,COG3464@2|Bacteria,2IG73@201174|Actinobacteria,4FSA1@85023|Microbacteriaceae	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3
SRD2_k127_1477944_0	477974.Daud_1050	5.45e-232	737.0	COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,2605R@186807|Peptococcaceae	186801|Clostridia	L	DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
SRD2_k127_1477944_1	28444.JODQ01000001_gene1938	1.625e-38	150.0	COG0596@1|root,COG0596@2|Bacteria,2GMMB@201174|Actinobacteria,4EQQD@85012|Streptosporangiales	201174|Actinobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
SRD2_k127_15060_1	929712.KI912613_gene2340	1.675e-25	117.0	COG0526@1|root,COG0526@2|Bacteria,2HZTZ@201174|Actinobacteria	201174|Actinobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
SRD2_k127_15060_0	929712.KI912613_gene2340	4.345e-36	141.0	COG0526@1|root,COG0526@2|Bacteria,2HZTZ@201174|Actinobacteria	201174|Actinobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
SRD2_k127_1509769_0	525904.Tter_2280	3.96e-192	624.0	COG2409@1|root,COG2409@2|Bacteria	2|Bacteria	D	Drug exporters of the RND superfamily	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
SRD2_k127_1509769_6	2002.JOEQ01000024_gene20	1.153e-08	63.0	2ADQJ@1|root,313FX@2|Bacteria,2H0DG@201174|Actinobacteria,4EJE4@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_1509769_5	640132.Srot_1695	2.727e-24	110.0	COG0406@1|root,COG0406@2|Bacteria,2GMXF@201174|Actinobacteria	201174|Actinobacteria	G	phosphoglycerate mutase	-	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	His_Phos_1
SRD2_k127_1509769_3	1121468.AUBR01000045_gene1801	1.116e-68	248.0	COG3643@1|root,COG3643@2|Bacteria,1TP5T@1239|Firmicutes,24905@186801|Clostridia,42EU0@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM Formiminotransferase	ftcD	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K01746	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000	-	-	-	FTCD,FTCD_N
SRD2_k127_1509769_1	1122604.JONR01000028_gene3489	9.807e-141	466.0	COG2730@1|root,COG2730@2|Bacteria	2|Bacteria	G	polysaccharide catabolic process	-	-	3.2.1.123	ko:K05991	-	-	-	-	ko00000,ko01000	-	GH5	-	Cellulase
SRD2_k127_1509769_4	1121952.ATXT01000019_gene1005	2.523e-32	145.0	COG2211@1|root,COG2211@2|Bacteria,2GJZG@201174|Actinobacteria,4FMI2@85023|Microbacteriaceae	201174|Actinobacteria	G	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SRD2_k127_1509769_2	1128421.JAGA01000002_gene1253	1.001e-109	372.0	COG0464@1|root,COG0464@2|Bacteria	2|Bacteria	O	ATPase activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA
SRD2_k127_1509769_7	67275.JOAP01000022_gene1805	0.0004444	48.0	COG2079@1|root,COG2079@2|Bacteria,2HVDJ@201174|Actinobacteria	201174|Actinobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
SRD2_k127_1511813_0	1283287.KB822578_gene2259	1.581e-101	349.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4DTE7@85009|Propionibacteriales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
SRD2_k127_1511813_1	469383.Cwoe_0961	6.086e-53	196.0	COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria,4CRTX@84995|Rubrobacteria	84995|Rubrobacteria	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N
SRD2_k127_1561227_2	1394178.AWOO02000029_gene4647	1.557e-12	79.0	2CIBE@1|root,32S7P@2|Bacteria,2IRU5@201174|Actinobacteria,4EK6S@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_1561227_1	1121377.KB906417_gene3855	1.557e-14	87.0	2FA15@1|root,342A8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_1561227_4	106370.Francci3_4049	0.0006157	42.0	COG0745@1|root,COG1511@1|root,COG3605@1|root,COG5002@1|root,COG0745@2|Bacteria,COG1511@2|Bacteria,COG3605@2|Bacteria,COG5002@2|Bacteria,2GKQX@201174|Actinobacteria,4EUER@85013|Frankiales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,Response_reg
SRD2_k127_160179_0	861299.J421_4122	2.191e-73	253.0	COG2761@1|root,COG2761@2|Bacteria,1ZUZU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
SRD2_k127_160179_1	1246995.AFR_16250	4.055e-67	252.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,2I8X1@201174|Actinobacteria,4DH0K@85008|Micromonosporales	201174|Actinobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GerE,HisKA_3
SRD2_k127_163955_16	258052.JNYV01000006_gene2679	1.577e-30	125.0	COG1403@1|root,COG1403@2|Bacteria,2IEFX@201174|Actinobacteria	201174|Actinobacteria	V	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
SRD2_k127_163955_20	219305.MCAG_01107	1.423e-17	91.0	COG0346@1|root,COG0346@2|Bacteria,2GRN1@201174|Actinobacteria,4DG9T@85008|Micromonosporales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SRD2_k127_163955_8	1168065.DOK_01589	1.234e-68	259.0	COG1960@1|root,COG1960@2|Bacteria,1P4V3@1224|Proteobacteria,1RZBS@1236|Gammaproteobacteria,1J4FZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N
SRD2_k127_163955_1	1207055.C100_11150	8.333e-122	402.0	COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TTRD@28211|Alphaproteobacteria,2K16D@204457|Sphingomonadales	204457|Sphingomonadales	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SRD2_k127_163955_18	591157.SSLG_04189	8.934e-20	100.0	COG5180@1|root,COG5180@2|Bacteria,2GKJ7@201174|Actinobacteria	201174|Actinobacteria	A	pathogenesis	-	-	-	-	-	-	-	-	-	-	-	-	GPDPase_memb
SRD2_k127_163955_22	326427.Cagg_0352	1.446e-07	64.0	2E0NP@1|root,32W7Q@2|Bacteria,2G9D8@200795|Chloroflexi,375QK@32061|Chloroflexia	32061|Chloroflexia	S	Domain of unknown function (DUF4350)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4350
SRD2_k127_163955_3	1128421.JAGA01000002_gene1058	5.227e-107	364.0	COG0714@1|root,COG0714@2|Bacteria,2NNMQ@2323|unclassified Bacteria	2|Bacteria	S	ATPase associated with various cellular	moxR2	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
SRD2_k127_163955_5	1128421.JAGA01000002_gene1057	1.389e-87	305.0	COG1721@1|root,COG1721@2|Bacteria	2|Bacteria	E	protein (some members contain a von Willebrand factor type A (vWA) domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,DUF58
SRD2_k127_163955_10	357808.RoseRS_3801	1.239e-55	208.0	COG1300@1|root,COG1300@2|Bacteria,2G8HV@200795|Chloroflexi,37546@32061|Chloroflexia	32061|Chloroflexia	S	Stage II sporulation protein M	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIM
SRD2_k127_163955_15	357808.RoseRS_1596	1.095e-34	145.0	COG1714@1|root,COG1714@2|Bacteria,2G7CB@200795|Chloroflexi,375N6@32061|Chloroflexia	32061|Chloroflexia	S	PFAM RDD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	RDD
SRD2_k127_163955_2	1120973.AQXL01000111_gene936	9.638e-120	398.0	COG0667@1|root,COG0667@2|Bacteria,1TRS0@1239|Firmicutes,4HBX5@91061|Bacilli,279G5@186823|Alicyclobacillaceae	91061|Bacilli	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SRD2_k127_163955_7	1278073.MYSTI_02808	6.902e-77	267.0	COG3342@1|root,COG3342@2|Bacteria,1MWQT@1224|Proteobacteria	1224|Proteobacteria	S	major pilin protein fima	MA20_16755	-	-	-	-	-	-	-	-	-	-	-	DUF1028
SRD2_k127_163955_11	285535.JOEY01000040_gene2510	5.273e-53	191.0	COG0346@1|root,COG0346@2|Bacteria,2IIM8@201174|Actinobacteria	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
SRD2_k127_163955_12	1229780.BN381_290041	6.277e-47	178.0	COG3217@1|root,COG3217@2|Bacteria,2GND9@201174|Actinobacteria	201174|Actinobacteria	S	MOSC domain	-	-	-	ko:K07140	-	-	-	-	ko00000	-	-	-	MOSC,MOSC_N
SRD2_k127_163955_0	401526.TcarDRAFT_1429	4.802e-169	560.0	COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,4H1W8@909932|Negativicutes	909932|Negativicutes	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
SRD2_k127_163955_17	1128421.JAGA01000003_gene2778	5.532e-23	113.0	COG0470@1|root,COG0470@2|Bacteria,2NS3K@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase III, delta subunit	holB	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
SRD2_k127_163955_9	765910.MARPU_08350	2.835e-62	246.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1WYBU@135613|Chromatiales	135613|Chromatiales	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
SRD2_k127_163955_4	891968.Anamo_1556	3.44e-93	326.0	COG1052@1|root,COG1052@2|Bacteria,3TARR@508458|Synergistetes	508458|Synergistetes	C	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
SRD2_k127_163955_13	401526.TcarDRAFT_0520	9.041e-43	169.0	COG0561@1|root,COG0561@2|Bacteria,1TR16@1239|Firmicutes,4H37M@909932|Negativicutes	909932|Negativicutes	S	Cof-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3,S6PP
SRD2_k127_163955_6	287986.DV20_19935	1.586e-82	284.0	COG4152@1|root,COG4152@2|Bacteria,2I2DK@201174|Actinobacteria,4DX3X@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SRD2_k127_163955_14	211114.JOEF01000001_gene7641	1.534e-40	169.0	COG1668@1|root,COG1668@2|Bacteria,2I9MY@201174|Actinobacteria,4DYBQ@85010|Pseudonocardiales	201174|Actinobacteria	CP	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
SRD2_k127_163955_21	743718.Isova_2215	2.546e-13	72.0	COG5485@1|root,COG5485@2|Bacteria,2HPCI@201174|Actinobacteria,4F5PX@85017|Promicromonosporaceae	201174|Actinobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
SRD2_k127_167781_1	867845.KI911784_gene2472	2.259e-50	201.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2G7ZS@200795|Chloroflexi,3757W@32061|Chloroflexia	32061|Chloroflexia	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,TPR_6,TPR_8
SRD2_k127_167781_2	1273538.G159_09205	4.363e-11	75.0	COG2204@1|root,COG4963@1|root,COG2204@2|Bacteria,COG4963@2|Bacteria,1UF2S@1239|Firmicutes,4HDR8@91061|Bacilli,26GA6@186818|Planococcaceae	91061|Bacilli	D	AAA domain	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,Response_reg
SRD2_k127_167781_0	1463895.JODA01000044_gene2134	5.925e-59	220.0	COG0515@1|root,COG0515@2|Bacteria,2GKFY@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
SRD2_k127_178174_5	1220589.CD32_12000	1.609e-20	98.0	COG2318@1|root,COG2318@2|Bacteria,1V8HE@1239|Firmicutes,4HJ3X@91061|Bacilli	91061|Bacilli	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB,DinB_2
SRD2_k127_178174_0	1122939.ATUD01000004_gene3934	9.26e-300	949.0	COG0296@1|root,COG0296@2|Bacteria,2GJ5C@201174|Actinobacteria,4CP7U@84995|Rubrobacteria	84995|Rubrobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
SRD2_k127_178174_4	287986.DV20_16630	2.305e-71	265.0	COG3281@1|root,COG3281@2|Bacteria,2GKAP@201174|Actinobacteria,4E0QY@85010|Pseudonocardiales	201174|Actinobacteria	G	protein, probably involved in trehalose biosynthesis	mak	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016310,GO:0034637,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046835,GO:0071704,GO:0071944,GO:1901576	2.7.1.175	ko:K16146	ko00500,ko01100,map00500,map01100	-	R09945	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH
SRD2_k127_178174_1	298654.FraEuI1c_0967	5.205e-276	858.0	COG0366@1|root,COG0366@2|Bacteria,2GIV1@201174|Actinobacteria,4EREC@85013|Frankiales	201174|Actinobacteria	G	Trehalose synthase	treS	GO:0000023,GO:0000271,GO:0003674,GO:0003824,GO:0004553,GO:0004556,GO:0005488,GO:0005509,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009311,GO:0009312,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016160,GO:0016161,GO:0016787,GO:0016798,GO:0016853,GO:0016866,GO:0033692,GO:0034637,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046872,GO:0047471,GO:0055114,GO:0071704,GO:0071944,GO:1901576	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	iNJ661.Rv0126	Alpha-amylase,Malt_amylase_C
SRD2_k127_178174_3	479435.Kfla_4941	5.155e-211	676.0	COG0366@1|root,COG0366@2|Bacteria,2GJKR@201174|Actinobacteria,4DMZD@85009|Propionibacteriales	201174|Actinobacteria	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
SRD2_k127_178174_2	1128421.JAGA01000001_gene2004	3.822e-271	846.0	COG1523@1|root,COG1523@2|Bacteria,2NPQU@2323|unclassified Bacteria	2|Bacteria	G	Carbohydrate-binding module 48 (Isoamylase N-terminal domain)	glgX	-	3.2.1.196,3.2.1.68	ko:K01214,ko:K02438	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02111,R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
SRD2_k127_18400_50	1449347.JQLN01000007_gene1590	3.617e-10	63.0	COG0683@1|root,COG0683@2|Bacteria,2GM00@201174|Actinobacteria,2M1W4@2063|Kitasatospora	201174|Actinobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
SRD2_k127_18400_17	1380394.JADL01000004_gene5787	5.347e-84	289.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSDS@28211|Alphaproteobacteria,2JVZW@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
SRD2_k127_18400_16	525904.Tter_0587	1.654e-87	303.0	COG4177@1|root,COG4177@2|Bacteria,2NPMP@2323|unclassified Bacteria	2|Bacteria	U	Branched-chain amino acid transport system / permease component	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
SRD2_k127_18400_15	1121430.JMLG01000001_gene2306	4.363e-89	312.0	COG0411@1|root,COG0411@2|Bacteria,1TR0P@1239|Firmicutes,2490B@186801|Clostridia,260GG@186807|Peptococcaceae	186801|Clostridia	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
SRD2_k127_18400_19	1120973.AQXL01000126_gene2925	1.114e-77	279.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,4HABJ@91061|Bacilli,27878@186823|Alicyclobacillaceae	91061|Bacilli	E	ABC transporter	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
SRD2_k127_18400_48	188626.HMPREF0321_2727	1.904e-19	103.0	COG0834@1|root,COG0834@2|Bacteria,2GJQW@201174|Actinobacteria,1ZWN9@145357|Dermacoccaceae	201174|Actinobacteria	ET	Bacterial periplasmic substrate-binding proteins	glnH	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
SRD2_k127_18400_40	1192034.CAP_6496	2.234e-34	136.0	COG0662@1|root,COG0662@2|Bacteria,1NADF@1224|Proteobacteria,4383M@68525|delta/epsilon subdivisions,2X9WE@28221|Deltaproteobacteria,2YVKF@29|Myxococcales	28221|Deltaproteobacteria	G	Mannose-6-phosphate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SRD2_k127_18400_7	1128421.JAGA01000004_gene2629	9.597e-139	462.0	COG1109@1|root,COG1109@2|Bacteria,2NNTH@2323|unclassified Bacteria	2|Bacteria	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	pgm	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
SRD2_k127_18400_25	644282.Deba_2698	1.924e-68	248.0	COG0836@1|root,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,42MDP@68525|delta/epsilon subdivisions,2WJEN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	TIGRFAM Mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase	manAC	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
SRD2_k127_18400_1	1196323.ALKF01000204_gene4414	2.397e-162	520.0	COG0192@1|root,COG0192@2|Bacteria,1TPCV@1239|Firmicutes,4HB33@91061|Bacilli,26QFD@186822|Paenibacillaceae	91061|Bacilli	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
SRD2_k127_18400_22	398578.Daci_5804	7.91e-73	276.0	COG1361@1|root,COG3055@1|root,COG3468@1|root,COG4625@1|root,COG1361@2|Bacteria,COG3055@2|Bacteria,COG3468@2|Bacteria,COG4625@2|Bacteria,1QU2X@1224|Proteobacteria,2VHDJ@28216|Betaproteobacteria	28216|Betaproteobacteria	MU	TIGRFAM outer membrane autotransporter barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,He_PIG,TIG
SRD2_k127_18400_0	926569.ANT_16170	3.117e-185	588.0	COG0499@1|root,COG0499@2|Bacteria,2G5X8@200795|Chloroflexi	200795|Chloroflexi	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
SRD2_k127_18400_18	379066.GAU_1468	2.73e-82	295.0	COG0524@1|root,COG0524@2|Bacteria,1ZSUT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
SRD2_k127_18400_9	926550.CLDAP_15490	5.146e-129	420.0	COG0451@1|root,COG0451@2|Bacteria,2G64F@200795|Chloroflexi	200795|Chloroflexi	M	PFAM NAD-dependent epimerase dehydratase	-	-	4.1.1.35,4.2.1.46	ko:K01710,ko:K08678	ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00793	R01384,R06513	RC00402,RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
SRD2_k127_18400_3	1382306.JNIM01000001_gene3879	8.558e-158	509.0	COG1004@1|root,COG1004@2|Bacteria,2G62F@200795|Chloroflexi	200795|Chloroflexi	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
SRD2_k127_18400_14	485913.Krac_3085	1.884e-94	342.0	COG3291@1|root,COG4934@1|root,COG3291@2|Bacteria,COG4934@2|Bacteria	2|Bacteria	O	collagen metabolic process	-	-	-	ko:K08677	-	-	-	-	ko00000,ko01002	-	-	-	He_PIG,PKD,Peptidase_S8,Pro-kuma_activ
SRD2_k127_18400_51	1150864.MILUP08_40622	2.927e-06	61.0	COG1470@1|root,COG3591@1|root,COG1470@2|Bacteria,COG3591@2|Bacteria,2I2YC@201174|Actinobacteria,4DHFK@85008|Micromonosporales	201174|Actinobacteria	G	Alpha galactosidase A	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Melibiase_2,Melibiase_2_C
SRD2_k127_18400_6	1045858.Bint_1756	1.848e-139	452.0	COG1089@1|root,COG1089@2|Bacteria,2J78G@203691|Spirochaetes	203691|Spirochaetes	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
SRD2_k127_18400_36	880073.Calab_0133	2.145e-38	165.0	COG0860@1|root,COG1361@1|root,COG3858@1|root,COG0860@2|Bacteria,COG1361@2|Bacteria,COG3858@2|Bacteria,2NQII@2323|unclassified Bacteria	2|Bacteria	M	Glyco_18	-	-	3.4.17.14,3.5.1.28	ko:K01448,ko:K07260,ko:K20276	ko00550,ko01100,ko01502,ko01503,ko02020,ko02024,map00550,map01100,map01502,map01503,map02020,map02024	M00651,M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko03036	-	-	-	Amidase_3,CHAP,CW_binding_2,Cu_amine_oxidN1,GBS_Bsp-like,Glyco_hydro_18,Glyco_hydro_25,Peptidase_C39_2,SH3_5,VanY,YSIRK_signal
SRD2_k127_18400_42	321332.CYB_1782	9.949e-31	132.0	COG0500@1|root,COG0500@2|Bacteria,1G9T2@1117|Cyanobacteria,1H1AQ@1129|Synechococcus	1117|Cyanobacteria	Q	similarity to GB CAH39666.1	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
SRD2_k127_18400_47	868131.MSWAN_0265	7.405e-22	110.0	COG1807@1|root,arCOG00566@2157|Archaea,2Y4H0@28890|Euryarchaeota	28890|Euryarchaeota	M	Protein of unknown function (DUF2723)	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
SRD2_k127_18400_30	562970.Btus_0876	1.004e-50	190.0	COG1682@1|root,COG1682@2|Bacteria,1TY8I@1239|Firmicutes,4I47R@91061|Bacilli,279PC@186823|Alicyclobacillaceae	91061|Bacilli	P	PFAM ABC-2 type transporter	-	-	-	ko:K09690	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC2_membrane
SRD2_k127_18400_12	1380347.JNII01000007_gene385	1.81e-99	339.0	COG1134@1|root,COG1134@2|Bacteria,2GIVF@201174|Actinobacteria,4ESAJ@85013|Frankiales	201174|Actinobacteria	GM	PFAM ABC transporter related	rfbB2	-	3.6.3.40	ko:K01990,ko:K09691,ko:K09693	ko02010,map02010	M00250,M00251,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.103,3.A.1.104	-	-	ABC_tran,Wzt_C
SRD2_k127_18400_33	323097.Nham_2765	3.832e-48	198.0	COG0438@1|root,COG0438@2|Bacteria,1NPMS@1224|Proteobacteria	1224|Proteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
SRD2_k127_18400_41	370438.PTH_1084	1.594e-32	147.0	COG1216@1|root,COG1216@2|Bacteria,1TSTE@1239|Firmicutes,249WH@186801|Clostridia,266SB@186807|Peptococcaceae	186801|Clostridia	M	Glycosyl transferase family group 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
SRD2_k127_18400_44	1340493.JNIF01000003_gene1962	3.023e-27	123.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25
SRD2_k127_18400_32	1499967.BAYZ01000139_gene142	2.383e-50	191.0	COG1216@1|root,COG1216@2|Bacteria,2NPYM@2323|unclassified Bacteria	2|Bacteria	L	Glycosyltransferase like family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
SRD2_k127_18400_37	1340493.JNIF01000003_gene4581	1.817e-37	154.0	COG0030@1|root,COG0030@2|Bacteria	2|Bacteria	J	rRNA (adenine-N6,N6-)-dimethyltransferase activity	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528,ko:K20444	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko01005,ko02000,ko03009	4.D.1.3	GT2,GT4	-	CTP_transf_like,Glyco_trans_1_4,Glycos_transf_2,Methyltransf_11,Methyltransf_12,Methyltransf_23,RrnaAD
SRD2_k127_18400_5	469371.Tbis_3172	5.293e-141	460.0	COG0463@1|root,COG0463@2|Bacteria,2I67S@201174|Actinobacteria,4EE61@85010|Pseudonocardiales	201174|Actinobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SRD2_k127_18400_28	1382306.JNIM01000001_gene2719	3.287e-59	232.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,Esterase,PQQ_2
SRD2_k127_18400_39	1303518.CCALI_00874	2.443e-35	157.0	COG4485@1|root,COG4485@2|Bacteria	2|Bacteria	M	Bacterial membrane protein, YfhO	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
SRD2_k127_18400_8	1869.MB27_01350	2.219e-134	439.0	COG0677@1|root,COG0677@2|Bacteria,2GK5K@201174|Actinobacteria,4DC0I@85008|Micromonosporales	201174|Actinobacteria	M	UDP binding domain	-	-	1.1.1.336	ko:K02472	ko00520,ko05111,map00520,map05111	-	R03317	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
SRD2_k127_18400_2	1121272.KB903272_gene124	1.915e-161	514.0	COG0451@1|root,COG0451@2|Bacteria,2I9T0@201174|Actinobacteria,4DA9R@85008|Micromonosporales	201174|Actinobacteria	GM	GDP-mannose 4,6 dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
SRD2_k127_18400_21	931627.MycrhDRAFT_5098	5.862e-73	255.0	COG1215@1|root,COG1215@2|Bacteria,2IBMN@201174|Actinobacteria,239CX@1762|Mycobacteriaceae	201174|Actinobacteria	MQ	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_11
SRD2_k127_18400_31	670487.Ocepr_0305	1.084e-50	188.0	COG0500@1|root,COG2226@2|Bacteria,1WIUM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
SRD2_k127_18400_43	411467.BACCAP_03752	1.679e-29	136.0	COG2141@1|root,COG2141@2|Bacteria	2|Bacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
SRD2_k127_18400_35	748449.Halha_2023	1.69e-45	186.0	COG1575@1|root,COG1575@2|Bacteria,1TSZV@1239|Firmicutes,24DJF@186801|Clostridia,3WBTB@53433|Halanaerobiales	186801|Clostridia	H	Belongs to the MenA family. Type 1 subfamily	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	iHN637.CLJU_RS19835	UbiA
SRD2_k127_18400_46	931276.Cspa_c37570	5.601e-23	114.0	COG1266@1|root,COG1266@2|Bacteria,1VEJJ@1239|Firmicutes,24EDW@186801|Clostridia,36GT3@31979|Clostridiaceae	186801|Clostridia	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
SRD2_k127_18400_34	1536772.R70723_29885	9.625e-48	183.0	COG1216@1|root,COG1216@2|Bacteria,1UYRR@1239|Firmicutes,4HEJ1@91061|Bacilli,26TD7@186822|Paenibacillaceae	91061|Bacilli	S	glycosyl transferase family 2	galnac-T15	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3,Glyco_transf_7C,Glycos_transf_2
SRD2_k127_18400_20	351607.Acel_0416	2.338e-75	265.0	COG1091@1|root,COG1091@2|Bacteria,2GNY8@201174|Actinobacteria,4ERZQ@85013|Frankiales	201174|Actinobacteria	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rmlD	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008831,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019305,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576	1.1.1.133,5.1.3.13	ko:K00067,ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777,R06514	RC00182,RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
SRD2_k127_18400_10	880073.Calab_3419	7.374e-129	422.0	COG1088@1|root,COG1088@2|Bacteria,2NNRC@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rfbB	GO:0000166,GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008460,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019305,GO:0019438,GO:0030312,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044464,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0048037,GO:0050662,GO:0051287,GO:0055086,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	4.2.1.46,4.2.1.76	ko:K01710,ko:K12450	ko00520,ko00521,ko00523,ko00525,ko01055,ko01130,map00520,map00521,map00523,map00525,map01055,map01130	M00793	R00293,R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3464	GDP_Man_Dehyd
SRD2_k127_18400_23	644283.Micau_6162	1.503e-72	252.0	COG1215@1|root,COG1215@2|Bacteria,2GP1D@201174|Actinobacteria,4DBWM@85008|Micromonosporales	201174|Actinobacteria	M	glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SRD2_k127_18400_38	1047013.AQSP01000144_gene832	1.782e-35	141.0	COG1898@1|root,COG1898@2|Bacteria,2NPIP@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	rfbC	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
SRD2_k127_18400_4	656024.FsymDg_1038	3.132e-143	462.0	COG1209@1|root,COG1209@2|Bacteria,2GP20@201174|Actinobacteria,4ET4A@85013|Frankiales	201174|Actinobacteria	M	PFAM Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
SRD2_k127_18400_26	1382356.JQMP01000004_gene418	1.735e-67	237.0	COG0463@1|root,COG0463@2|Bacteria,2G6TA@200795|Chloroflexi,27XT0@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SRD2_k127_18400_13	1499967.BAYZ01000017_gene6221	1.367e-96	333.0	COG2148@1|root,COG2148@2|Bacteria,2NP0Q@2323|unclassified Bacteria	2|Bacteria	M	Bacterial sugar transferase	wcaJ	-	-	ko:K03606	ko05111,map05111	-	-	-	ko00000,ko00001	-	-	-	Bac_transf,CoA_binding_3
SRD2_k127_18400_52	1150864.MILUP08_41266	3.548e-05	56.0	COG2244@1|root,COG2244@2|Bacteria	2|Bacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
SRD2_k127_18400_49	1209989.TepiRe1_1803	1.651e-15	89.0	COG3307@1|root,COG3307@2|Bacteria,1TQGY@1239|Firmicutes,24AB7@186801|Clostridia,42FXJ@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM O-antigen polymerase	-	-	-	ko:K18814	-	-	-	-	ko00000,ko02000	9.B.67.1	-	-	Wzy_C
SRD2_k127_18400_11	1382315.JPOI01000001_gene203	4.338e-101	338.0	COG0180@1|root,COG0180@2|Bacteria,1TPY7@1239|Firmicutes,4HA1K@91061|Bacilli,1WEM8@129337|Geobacillus	91061|Bacilli	J	tRNA synthetases class I (W and Y)	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
SRD2_k127_18400_45	485913.Krac_11174	7.969e-25	118.0	COG5542@1|root,COG5542@2|Bacteria,2G72S@200795|Chloroflexi	200795|Chloroflexi	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Mannosyl_trans2
SRD2_k127_18400_29	1123013.AUIC01000007_gene192	6.825e-57	220.0	COG1215@1|root,COG1215@2|Bacteria,2IK1V@201174|Actinobacteria	201174|Actinobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_18400_27	502025.Hoch_4127	3.828e-63	227.0	COG0842@1|root,COG0842@2|Bacteria,1N55T@1224|Proteobacteria,42N8F@68525|delta/epsilon subdivisions,2WK3B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	PFAM ABC-2 type transporter	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
SRD2_k127_18400_24	266117.Rxyl_1117	8.671e-72	248.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4CQ2R@84995|Rubrobacteria	84995|Rubrobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K09695	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC_tran
SRD2_k127_1877868_2	370438.PTH_0932	1.939e-149	482.0	COG1980@1|root,COG1980@2|Bacteria,1TSPD@1239|Firmicutes,24AT0@186801|Clostridia,263DQ@186807|Peptococcaceae	186801|Clostridia	G	Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P)	fbp	-	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
SRD2_k127_1877868_3	1382306.JNIM01000001_gene232	1.682e-133	455.0	COG4262@1|root,COG4262@2|Bacteria,2G5YS@200795|Chloroflexi	200795|Chloroflexi	S	Spermine/spermidine synthase domain	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
SRD2_k127_1877868_5	1382356.JQMP01000003_gene1909	5.859e-121	399.0	COG0489@1|root,COG0489@2|Bacteria,2G60P@200795|Chloroflexi,27XJW@189775|Thermomicrobia	189775|Thermomicrobia	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
SRD2_k127_1877868_9	300852.55771977	7.28e-60	224.0	COG0153@1|root,COG0153@2|Bacteria,1WIIN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Belongs to the GHMP kinase family. GalK subfamily	galK	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
SRD2_k127_1877868_13	595460.RRSWK_03552	1.152e-17	97.0	COG3250@1|root,COG3250@2|Bacteria,2J0FH@203682|Planctomycetes	203682|Planctomycetes	G	beta-galactosidase activity	-	-	3.2.1.25	ko:K01192	ko00511,ko04142,map00511,map04142	-	-	-	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_2
SRD2_k127_1877868_18	469383.Cwoe_2073	2.988e-13	75.0	2DMSR@1|root,32TF3@2|Bacteria,2IR08@201174|Actinobacteria,4CT5D@84995|Rubrobacteria	84995|Rubrobacteria	S	Putative Actinobacterial Holin-X, holin superfamily III	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_3_6
SRD2_k127_1877868_0	42256.RradSPS_0412	2.14e-227	724.0	COG1331@1|root,COG1331@2|Bacteria,2GJ88@201174|Actinobacteria,4CPJ8@84995|Rubrobacteria	84995|Rubrobacteria	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
SRD2_k127_1877868_7	1303518.CCALI_02196	3.852e-77	283.0	COG1633@1|root,COG1814@1|root,COG1633@2|Bacteria,COG1814@2|Bacteria	2|Bacteria	S	cellular manganese ion homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin,VIT1
SRD2_k127_1877868_11	309801.trd_0888	8.248e-37	145.0	COG0517@1|root,COG0517@2|Bacteria,2G8Z8@200795|Chloroflexi,27Z77@189775|Thermomicrobia	189775|Thermomicrobia	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SRD2_k127_1877868_4	562970.Btus_2368	1.798e-128	422.0	COG0372@1|root,COG0372@2|Bacteria,1TPPS@1239|Firmicutes,4H9YE@91061|Bacilli,278TC@186823|Alicyclobacillaceae	91061|Bacilli	C	Citrate synthase, C-terminal domain	citZ	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
SRD2_k127_1877868_16	105422.BBPM01000005_gene6243	4.371e-14	86.0	COG3345@1|root,COG3345@2|Bacteria,2GJJ1@201174|Actinobacteria,2NFDK@228398|Streptacidiphilus	201174|Actinobacteria	G	Glycosyl hydrolase family 36 N-terminal domain	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_36C,Glyco_hydro_36N,Melibiase
SRD2_k127_1877868_15	28444.JODQ01000006_gene339	8.575e-16	88.0	2EHGM@1|root,2ZY4I@2|Bacteria,2HB5C@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3147)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3147
SRD2_k127_1877868_17	1382359.JIAL01000001_gene1332	8.397e-14	82.0	2EM11@1|root,33EQJ@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3147)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3147
SRD2_k127_1877868_1	1244869.H261_12111	1.465e-181	578.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TR2Z@28211|Alphaproteobacteria,2JQ2N@204441|Rhodospirillales	204441|Rhodospirillales	C	FAD linked oxidases, C-terminal domain	-	-	1.1.2.4	ko:K00102	ko00620,map00620	-	R00197	RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
SRD2_k127_1877868_8	196162.Noca_3341	7.664e-67	232.0	COG1832@1|root,COG1832@2|Bacteria,2IJYY@201174|Actinobacteria	201174|Actinobacteria	S	PFAM CoA-binding domain protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
SRD2_k127_1877868_14	379066.GAU_3022	2.873e-16	83.0	COG1146@1|root,COG1146@2|Bacteria,1ZU19@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
SRD2_k127_1877868_12	35754.JNYJ01000089_gene6362	2.641e-31	134.0	COG1765@1|root,COG1765@2|Bacteria,2IFY4@201174|Actinobacteria,4DJDG@85008|Micromonosporales	201174|Actinobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
SRD2_k127_1877868_6	861299.J421_1634	1.217e-93	319.0	COG3214@1|root,COG3214@2|Bacteria	2|Bacteria	J	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
SRD2_k127_1877868_10	710111.FraQA3DRAFT_4238	2.726e-41	158.0	COG1403@1|root,COG1403@2|Bacteria,2GU7G@201174|Actinobacteria,4EV73@85013|Frankiales	201174|Actinobacteria	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
SRD2_k127_1880865_4	1121468.AUBR01000038_gene1956	2.714e-93	315.0	COG2262@1|root,COG2262@2|Bacteria,1TNZB@1239|Firmicutes,248IU@186801|Clostridia,42EMI@68295|Thermoanaerobacterales	186801|Clostridia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
SRD2_k127_1880865_2	477974.Daud_1603	9.09e-143	462.0	COG0436@1|root,COG0436@2|Bacteria,1TQD6@1239|Firmicutes,2491B@186801|Clostridia,260IS@186807|Peptococcaceae	186801|Clostridia	E	PFAM Aminotransferase class I and II	dapL	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
SRD2_k127_1880865_6	1392502.JNIO01000008_gene1840	2.409e-78	271.0	COG0253@1|root,COG0253@2|Bacteria,1TPMN@1239|Firmicutes,4H2QR@909932|Negativicutes	909932|Negativicutes	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
SRD2_k127_1880865_7	1123371.ATXH01000016_gene1844	2.689e-42	169.0	COG0324@1|root,COG0324@2|Bacteria,2GH70@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
SRD2_k127_1880865_3	309801.trd_1668	1.329e-110	391.0	COG0323@1|root,COG0323@2|Bacteria,2G5XU@200795|Chloroflexi,27XXX@189775|Thermomicrobia	189775|Thermomicrobia	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	-	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
SRD2_k127_1880865_0	1089550.ATTH01000001_gene2240	3.704e-219	708.0	COG0249@1|root,COG0249@2|Bacteria,4NEGB@976|Bacteroidetes,1FJ5H@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
SRD2_k127_1880865_8	1048834.TC41_1416	1.951e-30	122.0	COG2359@1|root,COG2359@2|Bacteria,1V6G8@1239|Firmicutes,4HIQV@91061|Bacilli,278J3@186823|Alicyclobacillaceae	91061|Bacilli	S	Stage V sporulation protein S	spoVS	-	-	ko:K06416	-	-	-	-	ko00000	-	-	-	SpoVS
SRD2_k127_1880865_5	429009.Adeg_1474	7.538e-82	281.0	COG1692@1|root,COG1692@2|Bacteria,1TR9P@1239|Firmicutes,24967@186801|Clostridia,42EQD@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM Metallophosphoesterase	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
SRD2_k127_1880865_1	1089548.KI783301_gene732	2.647e-153	499.0	COG1418@1|root,COG1418@2|Bacteria,1TP48@1239|Firmicutes,4HC9J@91061|Bacilli,3WDVN@539002|Bacillales incertae sedis	91061|Bacilli	S	Endoribonuclease that initiates mRNA decay	rny	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
SRD2_k127_193532_5	1229203.KI301992_gene888	6.782e-10	65.0	COG1388@1|root,COG1388@2|Bacteria	2|Bacteria	M	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
SRD2_k127_193532_3	1048339.KB913029_gene74	1.626e-28	120.0	COG0454@1|root,COG0456@2|Bacteria,2IFF2@201174|Actinobacteria,4ET59@85013|Frankiales	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SRD2_k127_193532_0	485913.Krac_8961	7.673e-203	642.0	COG0114@1|root,COG0114@2|Bacteria,2GBNI@200795|Chloroflexi	200795|Chloroflexi	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
SRD2_k127_193532_2	525904.Tter_0600	1.035e-32	129.0	COG1146@1|root,COG1146@2|Bacteria,2NPWS@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S binding domain	fdxA	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Fer4_7
SRD2_k127_193532_1	756499.Desde_2182	1.066e-53	214.0	COG1974@1|root,COG1974@2|Bacteria,1TQ3H@1239|Firmicutes,24AXJ@186801|Clostridia,2612Y@186807|Peptococcaceae	186801|Clostridia	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
SRD2_k127_193532_4	1120746.CCNL01000017_gene3129	9.755e-23	104.0	COG2262@1|root,COG2262@2|Bacteria,2NNWI@2323|unclassified Bacteria	2|Bacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
SRD2_k127_1945123_1	446469.Sked_15970	2.125e-31	132.0	COG1122@1|root,COG1122@2|Bacteria,2GMK1@201174|Actinobacteria	201174|Actinobacteria	P	ECF transporter, substrate-specific component	-	-	-	ko:K16927	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.32	-	-	ABC_tran,ECF_trnsprt
SRD2_k127_1945123_0	479434.Sthe_0926	2.5e-109	383.0	COG1122@1|root,COG1122@2|Bacteria,2G5RY@200795|Chloroflexi,27XTB@189775|Thermomicrobia	189775|Thermomicrobia	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
SRD2_k127_1945123_3	635013.TherJR_1258	1.289e-09	69.0	COG0619@1|root,COG0619@2|Bacteria,1TSB5@1239|Firmicutes,24AN7@186801|Clostridia,2616E@186807|Peptococcaceae	186801|Clostridia	P	PFAM Cobalt transport protein	-	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
SRD2_k127_1945123_2	926550.CLDAP_33490	2.407e-10	71.0	COG1657@1|root,COG1657@2|Bacteria,2G7AD@200795|Chloroflexi	200795|Chloroflexi	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_200499_3	1122947.FR7_4267	2.228e-60	223.0	COG1195@1|root,COG1195@2|Bacteria,1TP9U@1239|Firmicutes,4H1XT@909932|Negativicutes	909932|Negativicutes	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
SRD2_k127_200499_8	1179773.BN6_00050	8.202e-07	59.0	COG5512@1|root,COG5512@2|Bacteria,2GNQ4@201174|Actinobacteria,4E3Q7@85010|Pseudonocardiales	201174|Actinobacteria	S	Belongs to the UPF0232 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
SRD2_k127_200499_0	867903.ThesuDRAFT_02284	1.451e-98	359.0	COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,3WCQQ@538999|Clostridiales incertae sedis	186801|Clostridia	L	UvrD/REP helicase N-terminal domain	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
SRD2_k127_200499_2	485913.Krac_11897	4.165e-75	270.0	COG0707@1|root,COG0707@2|Bacteria,2G6CA@200795|Chloroflexi	200795|Chloroflexi	M	Glycosyltransferase 28 domain	-	-	2.4.1.46	ko:K03715	ko00561,ko01100,map00561,map01100	-	R02691	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT28	-	Glyco_tran_28_C,MGDG_synth
SRD2_k127_200499_4	426114.THI_0298	8.997e-36	151.0	COG5653@1|root,COG5653@2|Bacteria,1N7WR@1224|Proteobacteria,2VXRC@28216|Betaproteobacteria,1KN5M@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
SRD2_k127_200499_1	1048339.KB913029_gene2030	2.279e-86	301.0	COG0438@1|root,COG0438@2|Bacteria,2GJ57@201174|Actinobacteria,4ES4V@85013|Frankiales	201174|Actinobacteria	M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway	mshA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016740,GO:0016757,GO:0016758,GO:0044237,GO:0044249,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	2.4.1.250	ko:K15521	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_4,Glycos_transf_1
SRD2_k127_200499_5	316274.Haur_0172	5.165e-30	128.0	COG1011@1|root,COG1011@2|Bacteria,2G78N@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
SRD2_k127_200499_7	1463881.KL591041_gene6340	5.607e-16	89.0	COG0791@1|root,COG1388@1|root,COG0791@2|Bacteria,COG1388@2|Bacteria,2GIWB@201174|Actinobacteria	201174|Actinobacteria	M	PFAM NLP P60 protein	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60
SRD2_k127_200499_6	292459.STH1031	1.472e-26	121.0	COG0771@1|root,COG0771@2|Bacteria,1TQ3P@1239|Firmicutes,248GS@186801|Clostridia	186801|Clostridia	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iHN637.CLJU_RS20420	Mur_ligase_C,Mur_ligase_M
SRD2_k127_202623_15	1394178.AWOO02000023_gene5479	2.321e-64	232.0	COG2303@1|root,COG2303@2|Bacteria,2GJKS@201174|Actinobacteria	201174|Actinobacteria	E	Oxidoreductase	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N,Gluconate_2-dh3
SRD2_k127_202623_31	547163.BN979_03651	8.408e-05	53.0	COG3631@1|root,COG3631@2|Bacteria	2|Bacteria	S	light absorption	-	-	-	ko:K06893	-	-	-	-	ko00000	-	-	-	SnoaL_2
SRD2_k127_202623_10	485913.Krac_1006	1.752e-83	293.0	COG0477@1|root,COG2814@2|Bacteria,2G7AV@200795|Chloroflexi	200795|Chloroflexi	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	ko:K08162	-	-	-	-	ko00000,ko02000	2.A.1.2.21	-	-	MFS_1,MFS_1_like,Sugar_tr
SRD2_k127_202623_8	1380390.JIAT01000014_gene6146	3.423e-108	370.0	COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria,4CPIV@84995|Rubrobacteria	84995|Rubrobacteria	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
SRD2_k127_202623_0	562970.Btus_0327	0.0	1324.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1TPYV@1239|Firmicutes,4HBER@91061|Bacilli,2782J@186823|Alicyclobacillaceae	91061|Bacilli	E	B12 binding domain	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
SRD2_k127_202623_16	478741.JAFS01000002_gene465	4.676e-64	228.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Ubie_methyltran
SRD2_k127_202623_4	1121377.KB906401_gene3384	2.142e-167	559.0	COG3903@1|root,COG3903@2|Bacteria	2|Bacteria	K	ADP binding	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,AAA_22,BTAD,DUF4062,GerE,NB-ARC,TPR_12
SRD2_k127_202623_22	292459.STH983	4.925e-34	135.0	COG0316@1|root,COG0316@2|Bacteria,1V6IN@1239|Firmicutes,24U9B@186801|Clostridia	186801|Clostridia	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
SRD2_k127_202623_19	291985.CCSI01000004_gene618	3.378e-38	159.0	COG1853@1|root,COG1853@2|Bacteria,1RGYM@1224|Proteobacteria,2UCHI@28211|Alphaproteobacteria,2K5NZ@204457|Sphingomonadales	204457|Sphingomonadales	K	COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
SRD2_k127_202623_9	266117.Rxyl_0958	6.061e-93	317.0	COG0391@1|root,COG0391@2|Bacteria,2GJZ2@201174|Actinobacteria,4CPHB@84995|Rubrobacteria	84995|Rubrobacteria	S	Uncharacterised protein family UPF0052	-	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
SRD2_k127_202623_14	1382306.JNIM01000001_gene1895	3.19e-69	243.0	COG1478@1|root,COG1478@2|Bacteria,2G5TU@200795|Chloroflexi	200795|Chloroflexi	S	TIGRFAM F420-dependent oxidoreductase	-	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
SRD2_k127_202623_26	469383.Cwoe_4150	2.145e-24	111.0	COG1920@1|root,COG1920@2|Bacteria,2HNVD@201174|Actinobacteria,4CQ43@84995|Rubrobacteria	84995|Rubrobacteria	S	Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor	cofC	-	2.7.7.68	ko:K14941	ko00680,ko01120,map00680,map01120	M00378	R09397	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC
SRD2_k127_202623_21	1382306.JNIM01000001_gene3664	3.812e-37	147.0	COG2050@1|root,COG2050@2|Bacteria,2G751@200795|Chloroflexi	200795|Chloroflexi	Q	Thioesterase superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
SRD2_k127_202623_5	1144275.COCOR_04995	5.984e-139	457.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42Q1R@68525|delta/epsilon subdivisions,2WM4U@28221|Deltaproteobacteria,2YWW8@29|Myxococcales	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249,ko:K11731	ko00071,ko00280,ko00281,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00281,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754,R08089	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246,RC01893	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SRD2_k127_202623_28	622637.KE124774_gene889	8.836e-16	79.0	COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,2UF3C@28211|Alphaproteobacteria,36Z22@31993|Methylocystaceae	28211|Alphaproteobacteria	O	Sulfurtransferase TusA	tusA	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
SRD2_k127_202623_3	1121430.JMLG01000008_gene1568	5.194e-174	571.0	COG1239@1|root,COG1240@1|root,COG1239@2|Bacteria,COG1240@2|Bacteria,1UHYK@1239|Firmicutes,24BJ0@186801|Clostridia,260JT@186807|Peptococcaceae	186801|Clostridia	H	von Willebrand factor type A domain	-	-	6.6.1.1	ko:K03404,ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	AAA_5,Mg_chelatase,VWA_2
SRD2_k127_202623_7	1121430.JMLG01000008_gene1569	2.379e-116	387.0	COG1239@1|root,COG1239@2|Bacteria,1UHYK@1239|Firmicutes,24BJ0@186801|Clostridia,2609Y@186807|Peptococcaceae	186801|Clostridia	H	PFAM magnesium chelatase	-	-	6.6.1.1	ko:K03404,ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	AAA_5,Mg_chelatase,VWA_2
SRD2_k127_202623_12	326427.Cagg_0065	2.561e-81	289.0	COG1752@1|root,COG1752@2|Bacteria,2G7GM@200795|Chloroflexi,374ZF@32061|Chloroflexia	32061|Chloroflexia	S	PFAM Patatin	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
SRD2_k127_202623_27	1123507.ATVQ01000001_gene2175	7.92e-19	102.0	2CE4Q@1|root,2Z7WX@2|Bacteria,2H0P6@201174|Actinobacteria,1W81M@1268|Micrococcaceae	201174|Actinobacteria	S	Arylsulfotransferase (ASST)	-	-	-	-	-	-	-	-	-	-	-	-	Arylsulfotran_2
SRD2_k127_202623_13	857293.CAAU_0612	2.811e-72	272.0	COG4870@1|root,COG4870@2|Bacteria,1TS2S@1239|Firmicutes,248FU@186801|Clostridia,36EP3@31979|Clostridiaceae	186801|Clostridia	O	Repeat of unknown function (DUF346)	-	-	-	-	-	-	-	-	-	-	-	-	DUF346
SRD2_k127_202623_1	867903.ThesuDRAFT_00677	8.292e-245	769.0	COG0481@1|root,COG0481@2|Bacteria,1TP0G@1239|Firmicutes,247V8@186801|Clostridia,3WCEY@538999|Clostridiales incertae sedis	186801|Clostridia	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
SRD2_k127_202623_30	1218076.BAYB01000012_gene2390	3.845e-06	59.0	2CIPC@1|root,2Z9HB@2|Bacteria,1R3W8@1224|Proteobacteria,2VZKZ@28216|Betaproteobacteria,1K4V9@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
SRD2_k127_202623_11	1379701.JPJC01000252_gene1895	1.742e-82	303.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,2TT63@28211|Alphaproteobacteria,2K09I@204457|Sphingomonadales	204457|Sphingomonadales	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
SRD2_k127_202623_17	1121423.JONT01000001_gene1962	2.822e-54	206.0	COG1420@1|root,COG1420@2|Bacteria,1TQP7@1239|Firmicutes,247K2@186801|Clostridia,260NG@186807|Peptococcaceae	186801|Clostridia	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
SRD2_k127_202623_24	383372.Rcas_4391	6.526e-29	124.0	COG0576@1|root,COG0576@2|Bacteria,2G77I@200795|Chloroflexi,375MV@32061|Chloroflexia	32061|Chloroflexia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
SRD2_k127_202623_6	1121468.AUBR01000018_gene2684	1.082e-121	400.0	COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,248EM@186801|Clostridia,42ESV@68295|Thermoanaerobacterales	186801|Clostridia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
SRD2_k127_202623_20	1209989.TepiRe1_1202	1.438e-37	144.0	COG0537@1|root,COG0537@2|Bacteria,1V9ZJ@1239|Firmicutes,24JCW@186801|Clostridia,42GTY@68295|Thermoanaerobacterales	186801|Clostridia	FG	PFAM Histidine triad (HIT) protein	hinT	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
SRD2_k127_202623_23	644966.Tmar_2182	6.373e-31	132.0	COG1385@1|root,COG1385@2|Bacteria,1V1CT@1239|Firmicutes,249VK@186801|Clostridia,3WCMR@538999|Clostridiales incertae sedis	186801|Clostridia	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
SRD2_k127_202623_29	1540257.JQMW01000004_gene503	1.897e-13	76.0	COG0828@1|root,COG0828@2|Bacteria,1VEHU@1239|Firmicutes,24QP9@186801|Clostridia,36MKD@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
SRD2_k127_202623_25	235909.GK2491	1.537e-24	111.0	COG0319@1|root,COG0319@2|Bacteria,1V6BU@1239|Firmicutes,4HIIE@91061|Bacilli,1WGBV@129337|Geobacillus	91061|Bacilli	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
SRD2_k127_202623_18	1121423.JONT01000015_gene1345	1.77e-44	175.0	COG0193@1|root,COG0193@2|Bacteria,1V3NB@1239|Firmicutes,24HMC@186801|Clostridia,261YC@186807|Peptococcaceae	186801|Clostridia	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
SRD2_k127_202623_2	326427.Cagg_3741	1.326e-234	758.0	COG1197@1|root,COG1197@2|Bacteria,2G5UW@200795|Chloroflexi,375DR@32061|Chloroflexia	32061|Chloroflexia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
SRD2_k127_2043053_0	644283.Micau_3864	1.42e-19	96.0	2DBGS@1|root,2Z95N@2|Bacteria,2ICPX@201174|Actinobacteria,4DAIQ@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_2043053_1	1283299.AUKG01000001_gene2697	7.803e-14	85.0	COG1595@1|root,COG1595@2|Bacteria,2HXZ9@201174|Actinobacteria,4CQ7U@84995|Rubrobacteria	84995|Rubrobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SRD2_k127_2072159_1	1304874.JAFY01000005_gene1130	1.174e-21	100.0	COG1173@1|root,COG1173@2|Bacteria,3T9UM@508458|Synergistetes	508458|Synergistetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
SRD2_k127_2072159_0	546269.HMPREF0389_00808	6.091e-66	236.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,25R6Q@186804|Peptostreptococcaceae	186801|Clostridia	EP	Binding-protein-dependent transport system inner membrane component	oppB	-	-	ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
SRD2_k127_2072159_2	485913.Krac_3484	2.198e-19	101.0	COG4166@1|root,COG4166@2|Bacteria,2G5TA@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
SRD2_k127_2098603_24	1382306.JNIM01000001_gene2361	2.926e-91	317.0	COG1472@1|root,COG1472@2|Bacteria,2G639@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the glycosyl hydrolase 3 family	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
SRD2_k127_2098603_47	1306990.BARG01000034_gene4172	4.205e-63	233.0	COG0753@1|root,COG0753@2|Bacteria,2GN9F@201174|Actinobacteria	201174|Actinobacteria	P	Has an organic peroxide-dependent peroxidase activity	-	GO:0003674,GO:0003824,GO:0004601,GO:0005488,GO:0005506,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017144,GO:0019222,GO:0020037,GO:0031323,GO:0042221,GO:0042743,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050789,GO:0050794,GO:0050896,GO:0051186,GO:0051716,GO:0055114,GO:0065007,GO:0070887,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1990748,GO:2000377	1.11.1.6	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	M00532	R00009,R00602,R02670	RC00034,RC00767,RC02141,RC02755	ko00000,ko00001,ko00002,ko01000	-	-	-	Catalase,Catalase-rel
SRD2_k127_2098603_90	266117.Rxyl_2821	4.02e-17	94.0	COG2146@1|root,COG2146@2|Bacteria	2|Bacteria	P	nitrite reductase [NAD(P)H] activity	-	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
SRD2_k127_2098603_63	1382356.JQMP01000004_gene492	4.337e-40	164.0	COG1506@1|root,COG1506@2|Bacteria,2G8QF@200795|Chloroflexi,27YT1@189775|Thermomicrobia	189775|Thermomicrobia	E	Alpha/beta hydrolase of unknown function (DUF1100)	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
SRD2_k127_2098603_69	1009370.ALO_06583	2.799e-34	136.0	COG1278@1|root,COG1278@2|Bacteria,1VBBH@1239|Firmicutes,4H4UQ@909932|Negativicutes	909932|Negativicutes	K	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
SRD2_k127_2098603_56	1380393.JHVP01000001_gene2097	1.107e-47	182.0	COG2267@1|root,COG2267@2|Bacteria,2GM96@201174|Actinobacteria,4EV7N@85013|Frankiales	201174|Actinobacteria	I	Alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
SRD2_k127_2098603_29	1120936.KB907208_gene1218	7.774e-83	282.0	COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria,4EN3G@85012|Streptosporangiales	201174|Actinobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
SRD2_k127_2098603_31	1380394.JADL01000002_gene1160	1.342e-82	280.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2U1BU@28211|Alphaproteobacteria,2JW92@204441|Rhodospirillales	204441|Rhodospirillales	E	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
SRD2_k127_2098603_30	1122611.KB903957_gene52	8.983e-83	286.0	COG0559@1|root,COG0559@2|Bacteria,2HDZ9@201174|Actinobacteria,4EIQD@85012|Streptosporangiales	201174|Actinobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
SRD2_k127_2098603_39	1380394.JADL01000002_gene1158	3.434e-71	264.0	COG4177@1|root,COG4177@2|Bacteria,1P0DF@1224|Proteobacteria,2TUBF@28211|Alphaproteobacteria,2JUXE@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
SRD2_k127_2098603_27	443598.AUFA01000049_gene391	9.187e-85	296.0	COG0683@1|root,COG0683@2|Bacteria,1MV1Z@1224|Proteobacteria,2TRTD@28211|Alphaproteobacteria,3JRR8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
SRD2_k127_2098603_51	1172180.KB911792_gene3768	1.411e-55	208.0	COG4097@1|root,COG4097@2|Bacteria,2GQH2@201174|Actinobacteria	201174|Actinobacteria	P	nitric oxide dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Ferric_reduct
SRD2_k127_2098603_34	446462.Amir_1182	7.68e-77	269.0	COG1477@1|root,COG1477@2|Bacteria,2H74Y@201174|Actinobacteria,4DYZM@85010|Pseudonocardiales	201174|Actinobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
SRD2_k127_2098603_99	105422.BBPM01000035_gene1023	1.724e-12	76.0	COG1595@1|root,COG1595@2|Bacteria,2GKDD@201174|Actinobacteria,2NIRK@228398|Streptacidiphilus	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SRD2_k127_2098603_2	552811.Dehly_0760	4.864e-234	741.0	COG1217@1|root,COG1217@2|Bacteria,2G5NQ@200795|Chloroflexi,34D8B@301297|Dehalococcoidia	301297|Dehalococcoidia	T	Elongation factor G C-terminus	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
SRD2_k127_2098603_7	709986.Deima_2560	4.33e-141	459.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SRD2_k127_2098603_28	479434.Sthe_2380	9.575e-85	297.0	COG0513@1|root,COG0513@2|Bacteria,2G5VR@200795|Chloroflexi,27XXB@189775|Thermomicrobia	189775|Thermomicrobia	L	Belongs to the DEAD box helicase family	-	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
SRD2_k127_2098603_104	326427.Cagg_3576	2.267e-08	61.0	COG0860@1|root,COG3209@1|root,COG0860@2|Bacteria,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008745,GO:0016787,GO:0016810,GO:0016811,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0061783	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,RHS_repeat
SRD2_k127_2098603_86	1123229.AUBC01000004_gene3077	1.53e-21	106.0	COG1597@1|root,COG1597@2|Bacteria,1MY37@1224|Proteobacteria,2TT5I@28211|Alphaproteobacteria,3JWXE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Diacylglycerol kinase catalytic domain (presumed)	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
SRD2_k127_2098603_49	1173027.Mic7113_0231	9.256e-59	216.0	2DBB1@1|root,2Z854@2|Bacteria,1G05N@1117|Cyanobacteria,1H7Z3@1150|Oscillatoriales	1117|Cyanobacteria	S	Domain of Unknown Function (DUF1206)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1206
SRD2_k127_2098603_46	1206743.BAGM01000004_gene4412	3.128e-63	239.0	COG5001@1|root,COG5001@2|Bacteria,2IBN9@201174|Actinobacteria,4FWIJ@85025|Nocardiaceae	201174|Actinobacteria	T	Putative diguanylate phosphodiesterase	-	-	2.7.7.65	ko:K21023	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000	-	-	-	EAL,GGDEF
SRD2_k127_2098603_15	479434.Sthe_2006	5.396e-115	387.0	COG0432@1|root,COG1304@1|root,COG0432@2|Bacteria,COG1304@2|Bacteria,2G5RF@200795|Chloroflexi	200795|Chloroflexi	H	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
SRD2_k127_2098603_91	1380355.JNIJ01000035_gene4420	7.147e-17	90.0	COG0642@1|root,COG2199@1|root,COG5002@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2V7DW@28211|Alphaproteobacteria,3JXAY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,PAS_8,PAS_9,Response_reg
SRD2_k127_2098603_26	1254432.SCE1572_36735	1.967e-88	300.0	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,42RV4@68525|delta/epsilon subdivisions,2WP4W@28221|Deltaproteobacteria,2YVNU@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
SRD2_k127_2098603_58	269800.Tfu_0862	1.074e-44	170.0	COG1272@1|root,COG1272@2|Bacteria,2GJGQ@201174|Actinobacteria,4EIGX@85012|Streptosporangiales	201174|Actinobacteria	S	Haemolysin-III related	hlyIII	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
SRD2_k127_2098603_68	525904.Tter_2109	5.417e-35	153.0	COG1470@1|root,COG3664@1|root,COG1470@2|Bacteria,COG3664@2|Bacteria,2NQ48@2323|unclassified Bacteria	2|Bacteria	G	Glycosyl hydrolases family 39	-	-	-	-	-	-	-	-	-	-	-	-	DUF4384,NPCBM_assoc,PEGA
SRD2_k127_2098603_79	290397.Adeh_0857	4.338e-26	117.0	COG2197@1|root,COG2197@2|Bacteria,1NCBR@1224|Proteobacteria,433WZ@68525|delta/epsilon subdivisions,2X3XU@28221|Deltaproteobacteria,2YXHT@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
SRD2_k127_2098603_45	525904.Tter_2444	5.93e-64	230.0	COG0265@1|root,COG0265@2|Bacteria,2NQV1@2323|unclassified Bacteria	2|Bacteria	O	Trypsin-like peptidase domain	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
SRD2_k127_2098603_70	398767.Glov_3138	2.829e-34	134.0	COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,42W9X@68525|delta/epsilon subdivisions,2WSEM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA-1	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
SRD2_k127_2098603_41	1382306.JNIM01000001_gene3471	2.049e-68	244.0	COG0377@1|root,COG0377@2|Bacteria,2G6GB@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB1	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
SRD2_k127_2098603_67	485913.Krac_9043	2.92e-35	142.0	COG0852@1|root,COG0852@2|Bacteria,2G6WD@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
SRD2_k127_2098603_5	671143.DAMO_2698	1.765e-149	486.0	COG0649@1|root,COG0649@2|Bacteria,2NNWG@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00333,ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
SRD2_k127_2098603_71	1382306.JNIM01000001_gene3468	6.367e-34	143.0	COG1905@1|root,COG1905@2|Bacteria,2G70Y@200795|Chloroflexi	200795|Chloroflexi	C	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
SRD2_k127_2098603_8	1382306.JNIM01000001_gene3467	2.067e-140	463.0	COG1894@1|root,COG1894@2|Bacteria,2G5W1@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
SRD2_k127_2098603_6	1382306.JNIM01000001_gene3466	8.62e-142	473.0	COG3383@1|root,COG3383@2|Bacteria,2G65S@200795|Chloroflexi	200795|Chloroflexi	C	TIGRFAM NADH-quinone oxidoreductase, chain G	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
SRD2_k127_2098603_18	443143.GM18_0151	1.681e-105	358.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,42MMX@68525|delta/epsilon subdivisions,2WIX8@28221|Deltaproteobacteria,43S1U@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
SRD2_k127_2098603_61	1121926.AXWO01000010_gene3195	2.636e-41	171.0	COG1143@1|root,COG1143@2|Bacteria,2GJNU@201174|Actinobacteria,4EXRB@85014|Glycomycetales	201174|Actinobacteria	C	4Fe-4S binding domain	nuoI	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.6.5.3	ko:K00338,ko:K12143	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iNJ661.Rv3153	Fer4
SRD2_k127_2098603_85	1267533.KB906738_gene2125	1.151e-21	102.0	COG0839@1|root,COG0839@2|Bacteria,3Y4I4@57723|Acidobacteria,2JJ8B@204432|Acidobacteriia	204432|Acidobacteriia	C	plastoquinone oxidoreductase chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
SRD2_k127_2098603_78	1210045.ALNP01000026_gene740	1.614e-26	114.0	COG0713@1|root,COG0713@2|Bacteria,2IKV7@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00340,ko:K05576	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
SRD2_k127_2098603_11	880072.Desac_2106	2.934e-131	441.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIPT@28221|Deltaproteobacteria,2MS08@213462|Syntrophobacterales	28221|Deltaproteobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	nuoL-1	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
SRD2_k127_2098603_32	316067.Geob_1274	3.993e-82	297.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42MBQ@68525|delta/epsilon subdivisions,2X5HD@28221|Deltaproteobacteria,43T5M@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Proton-conducting membrane transporter	nuoM-2	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
SRD2_k127_2098603_20	880072.Desac_2104	9.499e-104	356.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42P7Z@68525|delta/epsilon subdivisions,2WK06@28221|Deltaproteobacteria,2MSIS@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
SRD2_k127_2098603_65	479434.Sthe_2694	3.471e-38	166.0	COG0642@1|root,COG5000@1|root,COG2205@2|Bacteria,COG5000@2|Bacteria,2G8M1@200795|Chloroflexi	200795|Chloroflexi	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4
SRD2_k127_2098603_12	485913.Krac_12114	3.058e-127	421.0	COG0039@1|root,COG0039@2|Bacteria,2G61S@200795|Chloroflexi	200795|Chloroflexi	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
SRD2_k127_2098603_23	1122182.KB903833_gene5401	7.81e-96	351.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria,4DBEY@85008|Micromonosporales	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc
SRD2_k127_2098603_53	504728.K649_09890	1.184e-54	201.0	2CEY7@1|root,2Z8CG@2|Bacteria	2|Bacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_2098603_1	1303518.CCALI_00474	4.004e-236	743.0	COG1053@1|root,COG1053@2|Bacteria	2|Bacteria	C	succinate dehydrogenase	sdhA	GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
SRD2_k127_2098603_83	1451261.AS96_00190	9.216e-23	104.0	COG4420@1|root,COG4420@2|Bacteria,2IHZA@201174|Actinobacteria,4FT5C@85023|Microbacteriaceae	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_2098603_17	1051632.TPY_3361	4.438e-108	355.0	COG0479@1|root,COG0479@2|Bacteria	2|Bacteria	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	sdhB1	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0247c	Fer2_3,Fer4_8
SRD2_k127_2098603_80	298653.Franean1_6118	4.187e-25	119.0	COG1333@1|root,COG1333@2|Bacteria,2GMGH@201174|Actinobacteria,4ERPQ@85013|Frankiales	201174|Actinobacteria	O	PFAM ResB family protein	resB	-	-	ko:K07399	-	-	-	-	ko00000	-	-	-	ResB
SRD2_k127_2098603_76	240292.Ava_2978	5.193e-31	139.0	COG1807@1|root,COG1807@2|Bacteria,1GCAK@1117|Cyanobacteria	1117|Cyanobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
SRD2_k127_2098603_84	1128421.JAGA01000002_gene1580	3.51e-22	111.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	GT87,PMT_2
SRD2_k127_2098603_52	1120949.KB903317_gene1944	2.333e-55	208.0	COG3358@1|root,COG3358@2|Bacteria,2IHE3@201174|Actinobacteria,4DCTC@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF1684)	-	-	-	ko:K09164	-	-	-	-	ko00000	-	-	-	DUF1684
SRD2_k127_2098603_100	1120949.KB903295_gene2156	3.651e-12	72.0	COG0457@1|root,COG0542@1|root,COG2319@1|root,COG0457@2|Bacteria,COG0542@2|Bacteria,COG2319@2|Bacteria,2GJ77@201174|Actinobacteria,4D8QE@85008|Micromonosporales	201174|Actinobacteria	O	Clp amino terminal domain, pathogenicity island component	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,Clp_N,Peptidase_C14,TIR_2
SRD2_k127_2098603_43	1280952.HJA_04476	2.23e-66	241.0	COG2200@1|root,COG2203@1|root,COG2200@2|Bacteria,COG2203@2|Bacteria,1MVJY@1224|Proteobacteria,2U1SU@28211|Alphaproteobacteria,43Z0M@69657|Hyphomonadaceae	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GAF_2
SRD2_k127_2098603_25	562970.Btus_0260	1.079e-89	305.0	COG0714@1|root,COG0714@2|Bacteria,1TPKR@1239|Firmicutes,4HA0T@91061|Bacilli,27829@186823|Alicyclobacillaceae	91061|Bacilli	S	PFAM ATPase associated with various cellular activities AAA_3	yeaC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
SRD2_k127_2098603_97	640081.Dsui_1000	1.017e-12	79.0	COG1721@1|root,COG1721@2|Bacteria	2|Bacteria	E	protein (some members contain a von Willebrand factor type A (vWA) domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
SRD2_k127_2098603_57	1313172.YM304_33500	4.291e-47	192.0	COG1305@1|root,COG1721@1|root,COG1305@2|Bacteria,COG1721@2|Bacteria,2HH1I@201174|Actinobacteria,4CP1R@84992|Acidimicrobiia	2|Bacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	DUF3488,DUF58,Transglut_core
SRD2_k127_2098603_64	396588.Tgr7_1037	1.843e-39	158.0	COG0590@1|root,COG0590@2|Bacteria,1RGU0@1224|Proteobacteria,1S60Z@1236|Gammaproteobacteria,1WXZ8@135613|Chromatiales	135613|Chromatiales	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
SRD2_k127_2098603_4	234267.Acid_1667	2.964e-184	591.0	COG1961@1|root,COG1961@2|Bacteria,3Y3F6@57723|Acidobacteria	57723|Acidobacteria	L	Recombinase	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
SRD2_k127_2098603_92	1157640.AQWO01000005_gene2267	1.965e-16	92.0	2ECZS@1|root,336WS@2|Bacteria,2HCMY@201174|Actinobacteria	201174|Actinobacteria	S	Replication-relaxation	-	-	-	-	-	-	-	-	-	-	-	-	Replic_Relax
SRD2_k127_2098603_101	1121385.AQXW01000004_gene2199	4.243e-12	68.0	2ASGK@1|root,31HWR@2|Bacteria,2GXEH@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_2098603_89	35754.JNYJ01000044_gene4376	2.492e-17	87.0	COG1598@1|root,COG1598@2|Bacteria	2|Bacteria	N	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
SRD2_k127_2098603_106	1205910.B005_2219	0.0002365	53.0	2F2I4@1|root,33VF6@2|Bacteria,2IH5F@201174|Actinobacteria,4EIVB@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	MauE
SRD2_k127_2098603_60	1101188.KI912157_gene205	1.446e-41	156.0	COG1961@1|root,COG1961@2|Bacteria,2HSUX@201174|Actinobacteria	201174|Actinobacteria	L	Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	HTH_7,Resolvase
SRD2_k127_2098603_48	292459.STH274	9.614e-62	222.0	COG1484@1|root,COG1484@2|Bacteria,1TRWF@1239|Firmicutes,24FIP@186801|Clostridia	186801|Clostridia	L	PFAM IstB domain protein ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21,IstB_IS21_ATP
SRD2_k127_2098603_35	391589.RGAI101_56	8.685e-76	273.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,2P1WD@2433|Roseobacter	28211|Alphaproteobacteria	L	COG4584 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	rve
SRD2_k127_2098603_3	1268303.RHODMAR_4047	1.046e-192	604.0	COG2141@1|root,COG2141@2|Bacteria,2GNR5@201174|Actinobacteria,4FUEW@85025|Nocardiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
SRD2_k127_2098603_66	1283299.AUKG01000001_gene2149	1.549e-37	146.0	COG1917@1|root,COG1917@2|Bacteria,2IFSF@201174|Actinobacteria,4CQ50@84995|Rubrobacteria	84995|Rubrobacteria	S	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SRD2_k127_2098603_50	1449353.JQMQ01000004_gene6333	2.012e-58	227.0	COG1807@1|root,COG1807@2|Bacteria,2GK3Q@201174|Actinobacteria,2NHW6@228398|Streptacidiphilus	201174|Actinobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
SRD2_k127_2098603_42	485913.Krac_1442	2.756e-67	244.0	COG1108@1|root,COG1108@2|Bacteria	2|Bacteria	P	ABC-type Mn2 Zn2 transport systems permease components	znuB	-	-	ko:K02075,ko:K09816	ko02010,map02010	M00242,M00244	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
SRD2_k127_2098603_40	1155718.KB891877_gene5386	3.881e-71	250.0	COG1108@1|root,COG1108@2|Bacteria,2GJ7H@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type Mn2 Zn2 transport systems permease components	-	-	-	ko:K02075	-	M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC-3
SRD2_k127_2098603_21	285514.JNWO01000016_gene9899	6.206e-100	335.0	COG1121@1|root,COG1121@2|Bacteria,2GP3A@201174|Actinobacteria	201174|Actinobacteria	P	ABC transporter	-	-	-	ko:K02074	-	M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC_tran
SRD2_k127_2098603_19	656024.FsymDg_3390	4.408e-105	352.0	COG0803@1|root,COG0803@2|Bacteria,2GM1K@201174|Actinobacteria,4ESYH@85013|Frankiales	201174|Actinobacteria	P	Zinc-uptake complex component A periplasmic	-	-	-	ko:K02077	-	M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ZnuA
SRD2_k127_2098603_93	1121346.KB899815_gene1947	1.337e-15	81.0	COG0735@1|root,COG0735@2|Bacteria,1V400@1239|Firmicutes,4HJX2@91061|Bacilli,26WRJ@186822|Paenibacillaceae	91061|Bacilli	P	Belongs to the Fur family	perR3	-	-	ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
SRD2_k127_2098603_0	106370.Francci3_2621	0.0	1366.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA2	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
SRD2_k127_2098603_16	644966.Tmar_1208	5.753e-111	374.0	COG4962@1|root,COG4962@2|Bacteria,1TQ0Z@1239|Firmicutes,249VS@186801|Clostridia,3WCV2@538999|Clostridiales incertae sedis	186801|Clostridia	U	PFAM Type II IV secretion system protein	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
SRD2_k127_2098603_22	1313172.YM304_21970	3.977e-96	321.0	COG1028@1|root,COG1028@2|Bacteria,2GK47@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
SRD2_k127_2098603_82	187272.Mlg_1980	1.656e-24	119.0	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,1S3UP@1236|Gammaproteobacteria,1WY5U@135613|Chromatiales	135613|Chromatiales	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
SRD2_k127_2098603_72	710111.FraQA3DRAFT_6069	7.285e-34	133.0	COG0526@1|root,COG0526@2|Bacteria,2HZTZ@201174|Actinobacteria	201174|Actinobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
SRD2_k127_2098603_33	929712.KI912613_gene2340	4.044e-79	270.0	COG0526@1|root,COG0526@2|Bacteria,2HZTZ@201174|Actinobacteria	201174|Actinobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
SRD2_k127_2098603_87	1131462.DCF50_p1734	1.465e-20	100.0	COG0239@1|root,COG0239@2|Bacteria,1VEH7@1239|Firmicutes,24QSV@186801|Clostridia,262VX@186807|Peptococcaceae	186801|Clostridia	U	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
SRD2_k127_2098603_74	300852.55771716	3.291e-32	130.0	COG1993@1|root,COG1993@2|Bacteria,1WKB2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
SRD2_k127_2098603_62	1321781.HMPREF1985_00814	4.388e-41	168.0	COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,4H37E@909932|Negativicutes	909932|Negativicutes	M	Belongs to the peptidase S11 family	-	-	-	-	-	-	-	-	-	-	-	-	PBP5_C,Peptidase_S11
SRD2_k127_2098603_96	1267535.KB906767_gene2892	1.845e-14	79.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	divK	-	-	ko:K11443	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
SRD2_k127_2098603_103	1172188.KB911824_gene3375	2.456e-10	66.0	COG0664@1|root,COG0664@2|Bacteria,2GYD2@201174|Actinobacteria,4FIZ6@85021|Intrasporangiaceae	201174|Actinobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
SRD2_k127_2098603_59	1131462.DCF50_p2074	2.082e-42	170.0	COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,2480S@186801|Clostridia,261CK@186807|Peptococcaceae	186801|Clostridia	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
SRD2_k127_2098603_37	1304874.JAFY01000002_gene1003	3.083e-74	263.0	COG0626@1|root,COG0626@2|Bacteria,3TBYA@508458|Synergistetes	508458|Synergistetes	E	Cys/Met metabolism PLP-dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Cys_Met_Meta_PP
SRD2_k127_2098603_14	525904.Tter_1314	3.983e-117	386.0	COG0031@1|root,COG0031@2|Bacteria,2NP1M@2323|unclassified Bacteria	2|Bacteria	E	Pyridoxal-phosphate dependent enzyme	cysM	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0033847,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.113,2.5.1.47	ko:K12339,ko:K21148	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04122,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230,map04122	M00021	R00897,R03132,R03601,R04859,R10610	RC00020,RC02814,RC02821,RC02876,RC03225	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SRD2_k127_2098603_81	748247.AZKH_2770	4.601e-25	112.0	COG1310@1|root,COG1310@2|Bacteria,1RM6Z@1224|Proteobacteria,2VUNY@28216|Betaproteobacteria	28216|Betaproteobacteria	S	JAB/MPN domain	-	-	3.13.1.6	ko:K21140	ko04122,map04122	-	R11524	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB
SRD2_k127_2098603_98	926569.ANT_04440	1.36e-12	76.0	2DPX2@1|root,333RW@2|Bacteria,2G7A0@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF4013)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4013
SRD2_k127_2098603_9	525904.Tter_1758	1.442e-139	458.0	COG1160@1|root,COG1160@2|Bacteria,2NNTW@2323|unclassified Bacteria	2|Bacteria	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	1.1.1.399,1.1.1.95	ko:K00058,ko:K03977	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko03009,ko04147	-	-	-	KH_dom-like,MMR_HSR1
SRD2_k127_2098603_36	309807.SRU_1481	1.796e-75	279.0	COG0240@1|root,COG0240@2|Bacteria,4NF4R@976|Bacteroidetes,1FIU2@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	I	glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
SRD2_k127_2098603_107	1347392.CCEZ01000043_gene545	0.0002841	48.0	2DR6A@1|root,33ACN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_2098603_94	1303692.SFUL_6406	1.834e-15	83.0	COG0745@1|root,COG0745@2|Bacteria,2GMP1@201174|Actinobacteria	201174|Actinobacteria	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
SRD2_k127_2098603_55	324602.Caur_0649	3.041e-49	189.0	COG1404@1|root,COG4447@1|root,COG1404@2|Bacteria,COG4447@2|Bacteria,2G8UU@200795|Chloroflexi,3759F@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4,Kelch_5,Peptidase_S8
SRD2_k127_2098603_44	316274.Haur_1444	2.974e-65	236.0	COG0284@1|root,COG0284@2|Bacteria,2G692@200795|Chloroflexi,3771N@32061|Chloroflexia	32061|Chloroflexia	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
SRD2_k127_2098603_10	575540.Isop_1423	9.845e-135	447.0	COG1915@1|root,COG1915@2|Bacteria,2IWVZ@203682|Planctomycetes	203682|Planctomycetes	S	PFAM LOR SDH bifunctional	-	-	-	-	-	-	-	-	-	-	-	-	Saccharop_dh_N
SRD2_k127_2098603_38	502025.Hoch_4049	1.739e-73	258.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42NQP@68525|delta/epsilon subdivisions,2WIQD@28221|Deltaproteobacteria,2YUVF@29|Myxococcales	28221|Deltaproteobacteria	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
SRD2_k127_2098603_73	1122939.ATUD01000014_gene1056	2.471e-32	145.0	COG2385@1|root,COG2385@2|Bacteria,2ID9T@201174|Actinobacteria,4CPMQ@84995|Rubrobacteria	84995|Rubrobacteria	D	Stage II sporulation protein	-	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	SpoIID
SRD2_k127_2098603_102	521393.JH806633_gene1767	7.669e-11	70.0	COG0730@1|root,COG0730@2|Bacteria,2I5VT@201174|Actinobacteria,4D4KC@85005|Actinomycetales	201174|Actinobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
SRD2_k127_2098603_88	888050.HMPREF9004_1804	2.397e-19	97.0	COG0730@1|root,COG0730@2|Bacteria,2I5VT@201174|Actinobacteria,4D4KC@85005|Actinomycetales	201174|Actinobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
SRD2_k127_2098603_75	1123250.KB908445_gene11	1.626e-31	125.0	COG1278@1|root,COG1278@2|Bacteria,1VBBH@1239|Firmicutes,4H4QP@909932|Negativicutes	909932|Negativicutes	K	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
SRD2_k127_2098603_54	404589.Anae109_2117	9.118e-50	190.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,42N0M@68525|delta/epsilon subdivisions,2WJ7D@28221|Deltaproteobacteria,2YWUR@29|Myxococcales	28221|Deltaproteobacteria	D	Phage integrase, N-terminal SAM-like domain	xerD	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
SRD2_k127_2098603_13	1306174.JODP01000003_gene1866	7.176e-120	407.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria	201174|Actinobacteria	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_4
SRD2_k127_2130695_8	1220589.CD32_12000	1.161e-18	93.0	COG2318@1|root,COG2318@2|Bacteria,1V8HE@1239|Firmicutes,4HJ3X@91061|Bacilli	91061|Bacilli	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB,DinB_2
SRD2_k127_2130695_0	485913.Krac_4356	0.0	1085.0	COG1048@1|root,COG1048@2|Bacteria,2G5NG@200795|Chloroflexi	200795|Chloroflexi	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
SRD2_k127_2130695_6	309801.trd_1695	5.79e-38	161.0	COG3858@1|root,COG3858@2|Bacteria,2G7HP@200795|Chloroflexi,27XZM@189775|Thermomicrobia	189775|Thermomicrobia	S	PFAM glycoside hydrolase, family 18	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18
SRD2_k127_2130695_3	208439.AJAP_19685	5.561e-70	248.0	COG0330@1|root,COG0330@2|Bacteria,2GJ1U@201174|Actinobacteria,4DY3Q@85010|Pseudonocardiales	201174|Actinobacteria	O	SPFH domain Band 7 family	hflK	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Band_7
SRD2_k127_2130695_9	888052.HMPREF9006_0181	1.898e-15	84.0	COG1585@1|root,COG1585@2|Bacteria,2IHZU@201174|Actinobacteria,4D5JE@85005|Actinomycetales	201174|Actinobacteria	OU	Nodulation efficiency protein D	nfeD	-	-	-	-	-	-	-	-	-	-	-	NfeD
SRD2_k127_2130695_5	1382356.JQMP01000003_gene2514	1.481e-40	156.0	COG1259@1|root,COG1259@2|Bacteria,2G6P6@200795|Chloroflexi,27Y7W@189775|Thermomicrobia	189775|Thermomicrobia	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
SRD2_k127_2130695_2	552811.Dehly_0095	1.817e-197	649.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2G5J0@200795|Chloroflexi,34CQM@301297|Dehalococcoidia	301297|Dehalococcoidia	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
SRD2_k127_2130695_4	1121428.DESHY_110226___1	3.624e-57	210.0	COG0266@1|root,COG0266@2|Bacteria,1TPM9@1239|Firmicutes,24BH2@186801|Clostridia,260YT@186807|Peptococcaceae	186801|Clostridia	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
SRD2_k127_2130695_10	675635.Psed_4826	9.786e-13	81.0	COG0671@1|root,COG0671@2|Bacteria,2I9FB@201174|Actinobacteria,4E7YS@85010|Pseudonocardiales	201174|Actinobacteria	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
SRD2_k127_2130695_1	479434.Sthe_0796	6.481e-270	846.0	COG0556@1|root,COG0556@2|Bacteria,2G5SU@200795|Chloroflexi,27XME@189775|Thermomicrobia	189775|Thermomicrobia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
SRD2_k127_2130695_7	502025.Hoch_2176	1.782e-20	105.0	COG1807@1|root,COG1807@2|Bacteria,1Q2FK@1224|Proteobacteria,4381I@68525|delta/epsilon subdivisions,2X3BM@28221|Deltaproteobacteria,2YUUG@29|Myxococcales	28221|Deltaproteobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_2155068_2	1121422.AUMW01000001_gene2338	1.929e-08	56.0	COG0721@1|root,COG0721@2|Bacteria,1VEK3@1239|Firmicutes,24RIE@186801|Clostridia,262GD@186807|Peptococcaceae	186801|Clostridia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
SRD2_k127_2155068_0	404589.Anae109_4338	5.681e-173	557.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,42MAH@68525|delta/epsilon subdivisions,2WJT7@28221|Deltaproteobacteria,2YTXJ@29|Myxococcales	28221|Deltaproteobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
SRD2_k127_2155068_3	1121405.dsmv_1253	7.675e-07	54.0	COG2261@1|root,COG2261@2|Bacteria,1NGEB@1224|Proteobacteria,42VUV@68525|delta/epsilon subdivisions,2WS8X@28221|Deltaproteobacteria,2MNUA@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
SRD2_k127_2155068_1	1382306.JNIM01000001_gene1327	2.05e-126	410.0	COG0064@1|root,COG0064@2|Bacteria,2G62Q@200795|Chloroflexi	200795|Chloroflexi	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
SRD2_k127_2163279_4	1382306.JNIM01000001_gene1170	1.855e-150	488.0	COG1960@1|root,COG1960@2|Bacteria,2G5K3@200795|Chloroflexi	200795|Chloroflexi	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SRD2_k127_2163279_7	1303518.CCALI_02842	3.161e-103	344.0	COG0074@1|root,COG0074@2|Bacteria	2|Bacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	GO:0001539,GO:0003674,GO:0003824,GO:0004774,GO:0004776,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006928,GO:0008150,GO:0008152,GO:0009361,GO:0009987,GO:0016020,GO:0016310,GO:0016874,GO:0016877,GO:0016878,GO:0019538,GO:0030312,GO:0031974,GO:0032991,GO:0036211,GO:0040007,GO:0040011,GO:0042709,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0046777,GO:0048870,GO:0051179,GO:0051674,GO:0070013,GO:0071704,GO:0071944,GO:0071973,GO:0097588,GO:1901564,GO:1902494	6.2.1.5,6.2.1.9	ko:K01902,ko:K02381,ko:K08692	ko00020,ko00630,ko00640,ko00660,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00346,M00374,M00620	R00405,R01256,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	iE2348C_1286.E2348C_0608,iYO844.BSU16100	CoA_binding,DUF1116,Ligase_CoA
SRD2_k127_2163279_6	670487.Ocepr_1026	6.675e-106	356.0	COG0045@1|root,COG0045@2|Bacteria,1WIT1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
SRD2_k127_2163279_0	357808.RoseRS_3291	7.716e-227	715.0	COG4799@1|root,COG4799@2|Bacteria,2G5IX@200795|Chloroflexi,3750V@32061|Chloroflexia	32061|Chloroflexia	I	PFAM carboxyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
SRD2_k127_2163279_10	515635.Dtur_1753	1.489e-55	215.0	COG1609@1|root,COG2199@1|root,COG2203@1|root,COG2206@1|root,COG1609@2|Bacteria,COG2199@2|Bacteria,COG2203@2|Bacteria,COG2206@2|Bacteria	2|Bacteria	T	PFAM metal-dependent phosphohydrolase, HD sub domain	rpfG_3	-	-	ko:K02030,ko:K02103,ko:K02529	-	M00236	-	-	ko00000,ko00002,ko02000,ko03000	3.A.1.3	-	-	GAF_2,GGDEF,HD,HD_5,HisKA_7TM,Peripla_BP_3
SRD2_k127_2163279_12	1146883.BLASA_5012	2.507e-50	195.0	COG1403@1|root,COG1403@2|Bacteria,2GU7G@201174|Actinobacteria,4EV73@85013|Frankiales	201174|Actinobacteria	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
SRD2_k127_2163279_1	765420.OSCT_1630	3.612e-219	691.0	COG1884@1|root,COG1884@2|Bacteria,2G5TP@200795|Chloroflexi,376KZ@32061|Chloroflexia	32061|Chloroflexia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
SRD2_k127_2163279_15	743525.TSC_c10740	8.512e-45	173.0	COG0500@1|root,COG2226@2|Bacteria,1WKDW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
SRD2_k127_2163279_17	469383.Cwoe_5865	1.168e-35	140.0	COG0346@1|root,COG0346@2|Bacteria,2IIPR@201174|Actinobacteria,4CQ97@84995|Rubrobacteria	84995|Rubrobacteria	E	Glyoxalase bleomycin resistance protein dioxygenase	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
SRD2_k127_2163279_5	926550.CLDAP_19720	3.283e-123	410.0	COG0174@1|root,COG0174@2|Bacteria,2G5U2@200795|Chloroflexi	200795|Chloroflexi	E	PFAM glutamine synthetase catalytic region	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
SRD2_k127_2163279_8	456442.Mboo_0434	2.704e-91	312.0	COG0515@1|root,arCOG03682@2157|Archaea,2XWZP@28890|Euryarchaeota	28890|Euryarchaeota	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	NosD,Pkinase
SRD2_k127_2163279_14	456442.Mboo_0438	4.907e-45	174.0	COG0631@1|root,arCOG05302@2157|Archaea	2157|Archaea	T	protein phosphatase 2C domain protein	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	FHA,PP2C,PP2C_2
SRD2_k127_2163279_2	456442.Mboo_0439	2.386e-204	649.0	COG0531@1|root,arCOG00009@2157|Archaea	2157|Archaea	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2,Trp_Tyr_perm,Usp
SRD2_k127_2163279_13	1172186.KB911480_gene5611	2.523e-48	194.0	COG2203@1|root,COG2508@1|root,COG2203@2|Bacteria,COG2508@2|Bacteria,2GM1G@201174|Actinobacteria,2353M@1762|Mycobacteriaceae	201174|Actinobacteria	QT	PucR C-terminal helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HTH_30
SRD2_k127_2163279_11	477641.MODMU_2338	5.595e-54	206.0	COG1277@1|root,COG1277@2|Bacteria,2GKW6@201174|Actinobacteria,4ERMU@85013|Frankiales	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
SRD2_k127_2163279_9	526227.Mesil_0789	4.701e-84	291.0	COG1131@1|root,COG1131@2|Bacteria,1WJ0H@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SRD2_k127_2163279_16	479431.Namu_3412	9.691e-36	150.0	COG5662@1|root,COG5662@2|Bacteria,2GN1B@201174|Actinobacteria,4ERKE@85013|Frankiales	201174|Actinobacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_2163279_18	1869.MB27_21190	1.189e-26	117.0	COG1595@1|root,COG1595@2|Bacteria,2IG6R@201174|Actinobacteria,4DD4B@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SRD2_k127_2163279_3	525904.Tter_1390	4.585e-156	500.0	COG0174@1|root,COG0174@2|Bacteria,2NNY0@2323|unclassified Bacteria	2|Bacteria	E	glutamine synthetase	glnA	GO:0001968,GO:0003674,GO:0003824,GO:0004356,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009405,GO:0009605,GO:0009607,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019222,GO:0019752,GO:0019899,GO:0020012,GO:0030162,GO:0030312,GO:0030682,GO:0031323,GO:0031325,GO:0032268,GO:0032270,GO:0035375,GO:0040007,GO:0043207,GO:0043436,GO:0044044,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070613,GO:0071704,GO:0071944,GO:0075136,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1903317,GO:1903319	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
SRD2_k127_2196621_0	671143.DAMO_1300	1.384e-19	104.0	COG0642@1|root,COG2203@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria	2|Bacteria	T	PhoQ Sensor	-	-	-	ko:K21009	ko02025,map02025	-	-	-	ko00000,ko00001	-	-	-	GAF,GAF_2,GAF_3,GGDEF,HATPase_c,HWE_HK,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1
SRD2_k127_2196621_1	195253.Syn6312_0784	4.763e-07	53.0	COG0477@1|root,COG2814@2|Bacteria,1G0DP@1117|Cyanobacteria,1GYJK@1129|Synechococcus	1117|Cyanobacteria	EGP	Multidrug efflux transporter, MFS family protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SRD2_k127_2197736_0	1463825.JNXC01000002_gene4814	1.818e-71	243.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4E0JW@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC transporter	nodI	-	-	ko:K09695	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC_tran
SRD2_k127_2197736_1	1146883.BLASA_1544	2.892e-67	241.0	COG0842@1|root,COG0842@2|Bacteria,2GVC2@201174|Actinobacteria,4ESWF@85013|Frankiales	201174|Actinobacteria	V	Transport permease protein	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
SRD2_k127_2197736_2	211114.JOEF01000001_gene7037	9.424e-20	103.0	COG0842@1|root,COG0842@2|Bacteria,2GMXR@201174|Actinobacteria,4E020@85010|Pseudonocardiales	201174|Actinobacteria	V	Transport permease protein	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
SRD2_k127_2213689_0	398767.Glov_0520	1.063e-155	501.0	COG3464@1|root,COG3464@2|Bacteria,1R4DH@1224|Proteobacteria,43AQ4@68525|delta/epsilon subdivisions,2X63W@28221|Deltaproteobacteria,43W3F@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	PFAM transposase IS204 IS1001 IS1096 IS1165 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,zf-ISL3
SRD2_k127_2213689_1	1123508.JH636456_gene119	1.269e-15	83.0	COG3335@1|root,COG3335@2|Bacteria,2J1BU@203682|Planctomycetes	203682|Planctomycetes	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
SRD2_k127_2252528_21	586416.GZ22_15280	4.781e-05	50.0	COG0356@1|root,COG0356@2|Bacteria,1TQIT@1239|Firmicutes,4H9NV@91061|Bacilli	91061|Bacilli	C	it plays a direct role in the translocation of protons across the membrane	atpB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
SRD2_k127_2252528_10	401526.TcarDRAFT_1456	3.439e-53	207.0	COG0472@1|root,COG0472@2|Bacteria,1TP9V@1239|Firmicutes,4H2U9@909932|Negativicutes	909932|Negativicutes	M	Glycosyltransferase, group 4 family	tagO	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
SRD2_k127_2252528_17	370438.PTH_2823	1.61e-17	94.0	COG2131@1|root,COG2131@2|Bacteria,1V3PU@1239|Firmicutes,24HF0@186801|Clostridia,261R0@186807|Peptococcaceae	186801|Clostridia	F	PFAM Cytidine and deoxycytidylate deaminase zinc-binding region	comEB	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
SRD2_k127_2252528_12	1121271.AUCM01000010_gene2307	5.106e-37	149.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,2TRIM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	-	GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
SRD2_k127_2252528_9	1121439.dsat_2823	7.916e-55	202.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,42PKA@68525|delta/epsilon subdivisions,2WNH0@28221|Deltaproteobacteria,2MBB2@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
SRD2_k127_2252528_3	525904.Tter_1654	3.208e-110	373.0	COG0216@1|root,COG0216@2|Bacteria,2NNKY@2323|unclassified Bacteria	2|Bacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02835,ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
SRD2_k127_2252528_6	1382306.JNIM01000001_gene2821	3.693e-66	241.0	COG3872@1|root,COG3872@2|Bacteria,2G5XQ@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF1385)	-	-	-	ko:K09153	-	-	-	-	ko00000	-	-	-	DUF1385
SRD2_k127_2252528_15	1230342.CTM_24678	1.97e-24	106.0	COG0254@1|root,COG0254@2|Bacteria,1VEGU@1239|Firmicutes,24QNZ@186801|Clostridia,36KES@31979|Clostridiaceae	186801|Clostridia	J	50S ribosomal protein L31	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
SRD2_k127_2252528_13	931276.Cspa_c13850	2.467e-35	149.0	COG1994@1|root,COG1994@2|Bacteria,1TSA9@1239|Firmicutes,24CR6@186801|Clostridia,36GS8@31979|Clostridiaceae	186801|Clostridia	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_2252528_4	485913.Krac_11293	6.296e-92	316.0	COG1180@1|root,COG1180@2|Bacteria	2|Bacteria	C	glycyl-radical enzyme activating activity	M1-291	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SRD2_k127_2252528_11	1267535.KB906767_gene2536	1.542e-38	152.0	COG0500@1|root,COG2226@2|Bacteria,3Y5QZ@57723|Acidobacteria,2JNVC@204432|Acidobacteriia	204432|Acidobacteriia	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
SRD2_k127_2252528_5	1116232.AHBF01000030_gene6503	3.957e-78	272.0	COG1494@1|root,COG1494@2|Bacteria,2GMQU@201174|Actinobacteria	201174|Actinobacteria	G	Fructose-1,6-bisphosphatase	glpX	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030145,GO:0030388,GO:0042132,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0046914,GO:0050308,GO:0071704,GO:1901135,GO:1901576	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
SRD2_k127_2252528_0	1121428.DESHY_30094___1	5.64e-224	734.0	COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,2482E@186801|Clostridia,260W1@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS01075	CTP_synth_N,GATase
SRD2_k127_2252528_7	485913.Krac_0962	2.607e-63	239.0	COG0515@1|root,COG0515@2|Bacteria,2G8CD@200795|Chloroflexi	200795|Chloroflexi	KLT	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Pkinase
SRD2_k127_2252528_8	525904.Tter_0072	2.512e-57	207.0	COG2220@1|root,COG2220@2|Bacteria,2NR9T@2323|unclassified Bacteria	2|Bacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
SRD2_k127_2252528_2	1211035.CD30_01105	5.411e-117	404.0	COG0018@1|root,COG0018@2|Bacteria,1TPEZ@1239|Firmicutes,4HAR3@91061|Bacilli,3IXEA@400634|Lysinibacillus	91061|Bacilli	J	Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
SRD2_k127_2252528_18	485913.Krac_0782	1.232e-16	93.0	COG0265@1|root,COG0265@2|Bacteria,2G6KV@200795|Chloroflexi	200795|Chloroflexi	O	PFAM peptidase S1 and S6, chymotrypsin Hap	-	-	1.3.1.74	ko:K08070	-	-	-	-	ko00000,ko01000	-	-	-	PDZ_2,Trypsin_2
SRD2_k127_2252528_20	66875.JODY01000027_gene5329	2.829e-06	55.0	COG0454@1|root,COG0456@2|Bacteria,2GQGN@201174|Actinobacteria	201174|Actinobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SRD2_k127_2252528_14	1304880.JAGB01000001_gene700	9.662e-25	106.0	COG4496@1|root,COG4496@2|Bacteria,1VA04@1239|Firmicutes,24MX9@186801|Clostridia	186801|Clostridia	S	protein, YerC YecD	-	-	-	-	-	-	-	-	-	-	-	-	Trp_repressor
SRD2_k127_2252528_1	381666.H16_A1919	2.574e-194	625.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHQD@28216|Betaproteobacteria,1K09N@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Aldehyde dehydrogenase	betB	-	1.2.1.3,1.2.1.8	ko:K00128,ko:K00130	ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135,M00555	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
SRD2_k127_2252528_16	316274.Haur_3809	2.714e-18	98.0	COG1657@1|root,COG1657@2|Bacteria,2G8NR@200795|Chloroflexi,37742@32061|Chloroflexia	32061|Chloroflexia	I	Prenyltransferase and squalene oxidase repeat	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans
SRD2_k127_2254643_16	1385518.N798_09855	4.228e-35	141.0	COG1404@1|root,COG1404@2|Bacteria,2GJYH@201174|Actinobacteria,4FJVD@85021|Intrasporangiaceae	201174|Actinobacteria	M	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8,TIG
SRD2_k127_2254643_4	383372.Rcas_1080	1.778e-108	371.0	COG2189@1|root,COG2189@2|Bacteria,2G5WR@200795|Chloroflexi,376Z9@32061|Chloroflexia	32061|Chloroflexia	H	PFAM DNA methylase N-4 N-6 domain protein	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
SRD2_k127_2254643_7	479434.Sthe_2028	4.921e-76	273.0	COG0612@1|root,COG0612@2|Bacteria,2G672@200795|Chloroflexi,27XSH@189775|Thermomicrobia	189775|Thermomicrobia	S	Belongs to the peptidase M16 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
SRD2_k127_2254643_25	1078020.KEK_01580	3.685e-22	109.0	COG2114@1|root,COG2114@2|Bacteria,2GN02@201174|Actinobacteria,23294@1762|Mycobacteriaceae	201174|Actinobacteria	T	Adenylate cyclase	-	GO:0003674,GO:0003824,GO:0004016,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0007154,GO:0007165,GO:0008150,GO:0009268,GO:0009628,GO:0009975,GO:0009987,GO:0010851,GO:0010854,GO:0010855,GO:0016020,GO:0016829,GO:0016849,GO:0023052,GO:0030145,GO:0030234,GO:0031279,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0046983,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071944,GO:0098772	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1264	Ad_Cy_reg,Guanylate_cyc
SRD2_k127_2254643_18	484770.UFO1_3003	1.391e-34	143.0	COG4420@1|root,COG4420@2|Bacteria,1V46X@1239|Firmicutes,4H7ET@909932|Negativicutes	909932|Negativicutes	S	Protein of unknown function (DUF1003)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003
SRD2_k127_2254643_29	502025.Hoch_0529	1.075e-12	70.0	COG3526@1|root,COG3526@2|Bacteria	2|Bacteria	O	Rdx family	-	-	-	ko:K07401	-	-	-	-	ko00000	-	-	-	Rdx
SRD2_k127_2254643_30	1307759.JOMJ01000003_gene515	0.0004003	48.0	COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,42TQG@68525|delta/epsilon subdivisions,2WQG8@28221|Deltaproteobacteria,2M8ZM@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM Smr protein MutS2	-	-	-	-	-	-	-	-	-	-	-	-	Smr
SRD2_k127_2254643_9	1123508.JH636446_gene6211	2.928e-72	252.0	COG0177@1|root,COG0177@2|Bacteria,2IYYT@203682|Planctomycetes	203682|Planctomycetes	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
SRD2_k127_2254643_28	661478.OP10G_3165	6.676e-13	83.0	28JU0@1|root,2Z9J3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_2254643_24	1121422.AUMW01000016_gene2031	1.858e-22	104.0	COG0360@1|root,COG0360@2|Bacteria,1VA18@1239|Firmicutes,24QZQ@186801|Clostridia,262KE@186807|Peptococcaceae	186801|Clostridia	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
SRD2_k127_2254643_21	1121104.AQXH01000002_gene663	3.072e-30	130.0	COG0629@1|root,COG0629@2|Bacteria,4NQBK@976|Bacteroidetes,1ISJD@117747|Sphingobacteriia	976|Bacteroidetes	L	Single-stranded DNA-binding protein	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
SRD2_k127_2254643_19	568816.Acin_0162	2.139e-30	121.0	COG0238@1|root,COG0238@2|Bacteria,1V9XS@1239|Firmicutes,4H53V@909932|Negativicutes	909932|Negativicutes	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
SRD2_k127_2254643_22	1122611.KB903997_gene7706	5.858e-26	118.0	COG0346@1|root,COG0346@2|Bacteria,2H8GV@201174|Actinobacteria	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_4
SRD2_k127_2254643_5	243164.DET0600	3.72e-103	351.0	COG0075@1|root,COG0075@2|Bacteria,2G5P3@200795|Chloroflexi,34CWR@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
SRD2_k127_2254643_1	1121430.JMLG01000030_gene1612	8.222e-151	497.0	COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,248H9@186801|Clostridia,260G0@186807|Peptococcaceae	186801|Clostridia	E	D-isomer specific 2-hydroxyacid dehydrogenase catalytic	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
SRD2_k127_2254643_10	477974.Daud_1638	7.112e-68	247.0	COG4198@1|root,COG4198@2|Bacteria,1TQSW@1239|Firmicutes,249E4@186801|Clostridia,2617E@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
SRD2_k127_2254643_26	345341.KUTG_04469	9.307e-18	87.0	COG2331@1|root,COG2331@2|Bacteria,2IQHE@201174|Actinobacteria,4E5CR@85010|Pseudonocardiales	201174|Actinobacteria	S	regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
SRD2_k127_2254643_6	246194.CHY_0373	1.098e-89	310.0	COG2270@1|root,COG2270@2|Bacteria,1UHZ6@1239|Firmicutes,25E7U@186801|Clostridia,42FKF@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
SRD2_k127_2254643_17	941824.TCEL_00996	6.087e-35	137.0	COG3118@1|root,COG3118@2|Bacteria,1VA3Y@1239|Firmicutes,24MM5@186801|Clostridia,36KFX@31979|Clostridiaceae	186801|Clostridia	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
SRD2_k127_2254643_14	1380387.JADM01000009_gene3107	1.563e-43	163.0	COG2050@1|root,COG2050@2|Bacteria,1RGVP@1224|Proteobacteria	1224|Proteobacteria	Q	Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl- CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA)	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
SRD2_k127_2254643_2	1037409.BJ6T_56240	1.046e-143	472.0	COG2114@1|root,COG2267@1|root,COG2114@2|Bacteria,COG2267@2|Bacteria,1NIJG@1224|Proteobacteria,2U09P@28211|Alphaproteobacteria,3JTK8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IT	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Guanylate_cyc,Hydrolase_4,Trans_reg_C
SRD2_k127_2254643_0	204669.Acid345_4185	1.121e-180	583.0	COG1282@1|root,COG1282@2|Bacteria,3Y42H@57723|Acidobacteria,2JM1F@204432|Acidobacteriia	204432|Acidobacteriia	C	NAD(P) transhydrogenase beta subunit	-	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
SRD2_k127_2254643_20	298654.FraEuI1c_5769	2.156e-30	126.0	COG3288@1|root,COG3288@2|Bacteria,2IKR9@201174|Actinobacteria	201174|Actinobacteria	C	NADP transhydrogenase	pntAB	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
SRD2_k127_2254643_3	204669.Acid345_4187	3.827e-118	391.0	COG3288@1|root,COG3288@2|Bacteria,3Y2S0@57723|Acidobacteria,2JM52@204432|Acidobacteriia	204432|Acidobacteriia	C	Alanine dehydrogenase/PNT, N-terminal domain	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
SRD2_k127_2254643_27	218284.CCDN010000001_gene1021	2.995e-14	76.0	COG3369@1|root,COG3369@2|Bacteria,1VFK3@1239|Firmicutes,4HNHY@91061|Bacilli,1ZIZQ@1386|Bacillus	91061|Bacilli	S	Iron-binding zinc finger CDGSH type	-	-	-	-	-	-	-	-	-	-	-	-	zf-CDGSH
SRD2_k127_2254643_11	1206725.BAFU01000224_gene3746	6.801e-66	250.0	COG1839@1|root,COG1839@2|Bacteria,2IAR3@201174|Actinobacteria,4FYWC@85025|Nocardiaceae	201174|Actinobacteria	S	Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
SRD2_k127_2254643_12	1121272.KB903291_gene3329	2.642e-53	190.0	2BKAB@1|root,32EQK@2|Bacteria,2GXJB@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_2254643_13	1313172.YM304_29460	4.06e-47	184.0	COG5012@1|root,COG5012@2|Bacteria,2GKAY@201174|Actinobacteria	201174|Actinobacteria	S	Cobalamin B12-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
SRD2_k127_2254643_8	1298863.AUEP01000006_gene3403	2.556e-72	267.0	COG1028@1|root,COG1028@2|Bacteria,2GIYQ@201174|Actinobacteria,4DPX7@85009|Propionibacteriales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SRD2_k127_2254643_23	929712.KI912613_gene2333	1.036e-22	102.0	COG3427@1|root,COG3427@2|Bacteria	2|Bacteria	E	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	COXG,Polyketide_cyc2
SRD2_k127_2254643_15	177439.DP2148	2.138e-40	154.0	COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,42N4S@68525|delta/epsilon subdivisions,2WJXX@28221|Deltaproteobacteria,2MMRK@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
SRD2_k127_2264070_4	1042375.AFPL01000044_gene1286	6.222e-82	282.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,464ZX@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	ATPase with chaperone activity	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
SRD2_k127_2264070_7	1121468.AUBR01000036_gene1295	3.088e-62	225.0	COG0758@1|root,COG0758@2|Bacteria,1TPP7@1239|Firmicutes,24AS2@186801|Clostridia,42FQZ@68295|Thermoanaerobacterales	186801|Clostridia	L	TIGRFAM DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
SRD2_k127_2264070_0	671143.DAMO_0060	4.602e-200	647.0	COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,2NNS8@2323|unclassified Bacteria	2|Bacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360	5.99.1.2	ko:K03168,ko:K07479	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topo_Zn_Ribbon,Topoisom_bac,Toprim,zf-C4_Topoisom
SRD2_k127_2264070_3	1304880.JAGB01000001_gene218	9.424e-84	297.0	COG0052@1|root,COG0052@2|Bacteria,1TPNA@1239|Firmicutes,247ZR@186801|Clostridia	186801|Clostridia	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
SRD2_k127_2264070_8	648996.Theam_0090	1.949e-59	212.0	COG0264@1|root,COG0264@2|Bacteria,2G3RA@200783|Aquificae	200783|Aquificae	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
SRD2_k127_2264070_2	443144.GM21_1487	3.255e-98	329.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,42M3X@68525|delta/epsilon subdivisions,2WJDF@28221|Deltaproteobacteria,43SW0@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
SRD2_k127_2264070_6	479434.Sthe_1737	6.944e-65	226.0	COG0233@1|root,COG0233@2|Bacteria,2G6FY@200795|Chloroflexi,27Y79@189775|Thermomicrobia	189775|Thermomicrobia	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
SRD2_k127_2264070_5	1382306.JNIM01000001_gene1336	2.25e-79	271.0	COG0020@1|root,COG0020@2|Bacteria,2G65C@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
SRD2_k127_2264070_10	635013.TherJR_1363	1.139e-32	141.0	COG4589@1|root,COG4589@2|Bacteria,1TT0Q@1239|Firmicutes,25HJP@186801|Clostridia,267IB@186807|Peptococcaceae	186801|Clostridia	S	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
SRD2_k127_2264070_1	644282.Deba_0746	6.201e-100	339.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,42NI1@68525|delta/epsilon subdivisions,2WK14@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
SRD2_k127_2264070_9	1292035.H476_0868	7.82e-36	146.0	COG0750@1|root,COG0750@2|Bacteria,1TPMC@1239|Firmicutes,247MT@186801|Clostridia,25R2P@186804|Peptostreptococcaceae	186801|Clostridia	M	zinc metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
SRD2_k127_2270340_3	926569.ANT_18650	5.338e-21	98.0	COG1131@1|root,COG1131@2|Bacteria,2G5PC@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SRD2_k127_2270340_1	880072.Desac_0031	1.468e-37	151.0	COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,42SH9@68525|delta/epsilon subdivisions,2WPWW@28221|Deltaproteobacteria,2MRMI@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux
SRD2_k127_2270340_2	1173029.JH980292_gene2233	4.472e-21	109.0	COG3225@1|root,COG3225@2|Bacteria,1G0JN@1117|Cyanobacteria,1H8SY@1150|Oscillatoriales	1117|Cyanobacteria	N	transport system involved in gliding motility, auxiliary component	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
SRD2_k127_2270340_0	760568.Desku_3289	4.167e-222	705.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,260WE@186807|Peptococcaceae	186801|Clostridia	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
SRD2_k127_2307897_0	711393.AYRX01000087_gene5088	7.605e-41	155.0	COG0665@1|root,COG0665@2|Bacteria,2GNAE@201174|Actinobacteria	201174|Actinobacteria	E	PFAM FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
SRD2_k127_2307897_2	261292.Nit79A3_2014	1.405e-06	60.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2VHHS@28216|Betaproteobacteria,372HQ@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3,SurA_N
SRD2_k127_2307897_1	1382306.JNIM01000001_gene1240	3.481e-22	103.0	COG1514@1|root,COG1514@2|Bacteria,2G76S@200795|Chloroflexi	200795|Chloroflexi	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
SRD2_k127_2307897_3	266264.Rmet_6547	1.929e-06	56.0	COG2199@1|root,COG2199@2|Bacteria,1RGCV@1224|Proteobacteria,2WGQE@28216|Betaproteobacteria,1KIJZ@119060|Burkholderiaceae	28216|Betaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2222,EAL,GGDEF,HAMP
SRD2_k127_2336887_0	886293.Sinac_4759	2.358e-135	445.0	COG4584@1|root,COG4584@2|Bacteria,2J4C3@203682|Planctomycetes	203682|Planctomycetes	L	PFAM Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
SRD2_k127_2336887_1	13689.BV96_04746	9.369e-84	293.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TRGY@28211|Alphaproteobacteria,2K0MX@204457|Sphingomonadales	204457|Sphingomonadales	L	Bacterial dnaA  protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
SRD2_k127_233772_0	357808.RoseRS_2852	1.037e-204	650.0	COG5421@1|root,COG5421@2|Bacteria,2G7SD@200795|Chloroflexi,376XS@32061|Chloroflexia	32061|Chloroflexia	L	COGs COG5421 Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_2388544_9	926550.CLDAP_07830	1.77e-09	70.0	COG4447@1|root,COG4447@2|Bacteria,2G66V@200795|Chloroflexi	200795|Chloroflexi	G	glycosyl hydrolase, BNR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
SRD2_k127_2388544_1	196490.AUEZ01000014_gene1999	2.823e-134	452.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TRNK@28211|Alphaproteobacteria,3JVXA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
SRD2_k127_2388544_5	1155718.KB891919_gene4241	1.128e-68	266.0	COG3292@1|root,COG3386@1|root,COG3292@2|Bacteria,COG3386@2|Bacteria,2IAXB@201174|Actinobacteria	201174|Actinobacteria	GT	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_2388544_6	1303518.CCALI_00707	1.499e-58	213.0	COG2316@1|root,COG2316@2|Bacteria	2|Bacteria	J	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06951	-	-	-	-	ko00000	-	-	-	HD
SRD2_k127_2388544_7	673862.BABL1_9	1.312e-45	177.0	COG4112@1|root,COG4112@2|Bacteria,1RG92@1224|Proteobacteria,42S41@68525|delta/epsilon subdivisions,2WNMM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_2388544_4	37919.EP51_29010	1.126e-68	252.0	COG1028@1|root,COG1028@2|Bacteria,2GIX2@201174|Actinobacteria,4G8JY@85025|Nocardiaceae	201174|Actinobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
SRD2_k127_2388544_2	1150599.MPHLEI_22184	1.258e-118	394.0	COG0447@1|root,COG0447@2|Bacteria,2GK5G@201174|Actinobacteria,238F2@1762|Mycobacteriaceae	201174|Actinobacteria	H	enoyl-CoA hydratase isomerase family	menB	-	4.1.3.36	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07263	RC01923	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
SRD2_k127_2388544_3	926569.ANT_13710	9.024e-81	274.0	COG0179@1|root,COG0179@2|Bacteria,2G6H8@200795|Chloroflexi	200795|Chloroflexi	Q	PFAM fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
SRD2_k127_2388544_10	4155.Migut.L00887.1.p	0.0002737	51.0	KOG1565@1|root,KOG1565@2759|Eukaryota,37MB0@33090|Viridiplantae,3GFCB@35493|Streptophyta,44EZR@71274|asterids	33090|Viridiplantae	O	Belongs to the peptidase M10A family	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,Peptidase_M10
SRD2_k127_2388544_0	1121468.AUBR01000010_gene2456	6.231e-185	593.0	COG0119@1|root,COG0119@2|Bacteria,1TRIK@1239|Firmicutes,249Q4@186801|Clostridia,42EVB@68295|Thermoanaerobacterales	186801|Clostridia	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA3	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
SRD2_k127_2388544_8	1303518.CCALI_01021	6.512e-16	84.0	COG0119@1|root,COG0119@2|Bacteria	2|Bacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	cimA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
SRD2_k127_2448416_3	1232410.KI421414_gene2821	3.531e-13	83.0	COG0419@1|root,COG0419@2|Bacteria,1Q1A7@1224|Proteobacteria,4375R@68525|delta/epsilon subdivisions,2X23H@28221|Deltaproteobacteria,43SPP@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	AAA domain	sbcC-1	-	-	-	-	-	-	-	-	-	-	-	AAA_23
SRD2_k127_2448416_1	1324957.K933_12346	3.193e-59	221.0	COG0006@1|root,arCOG01002@2157|Archaea,2XUN0@28890|Euryarchaeota,23SX2@183963|Halobacteria	183963|Halobacteria	E	COG0006 Xaa-Pro aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
SRD2_k127_2448416_2	749414.SBI_08761	1.065e-58	207.0	COG3467@1|root,COG3467@2|Bacteria,2IFJS@201174|Actinobacteria	201174|Actinobacteria	S	pyridoxamine 5-phosphate	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
SRD2_k127_2448416_0	298654.FraEuI1c_5742	3.904e-168	538.0	COG1960@1|root,COG1960@2|Bacteria,2GNTA@201174|Actinobacteria,4EU1D@85013|Frankiales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SRD2_k127_2464141_4	246196.MSMEI_3882	6.134e-46	173.0	COG1309@1|root,COG1309@2|Bacteria,2GN4G@201174|Actinobacteria,239T6@1762|Mycobacteriaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
SRD2_k127_2464141_5	744980.TRICHSKD4_4955	1.747e-07	63.0	COG0741@1|root,COG0741@2|Bacteria	2|Bacteria	M	lytic transglycosylase activity	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	Peptidase_M23,SLT,TMP_2
SRD2_k127_2464141_1	1298863.AUEP01000001_gene785	2.578e-92	329.0	COG4585@1|root,COG4585@2|Bacteria,2GMMU@201174|Actinobacteria,4DV3H@85009|Propionibacteriales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
SRD2_k127_2464141_2	479432.Sros_1995	3.433e-50	204.0	COG0515@1|root,COG3087@1|root,COG0515@2|Bacteria,COG3087@2|Bacteria,2GKFY@201174|Actinobacteria,4EGUP@85012|Streptosporangiales	201174|Actinobacteria	KLT	SMART serine threonine protein kinase	pkn5	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
SRD2_k127_2464141_0	1179773.BN6_25650	5.32e-160	527.0	COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria,4E2A3@85010|Pseudonocardiales	201174|Actinobacteria	Q	Wax ester synthase-like Acyl-CoA acyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
SRD2_k127_2464141_3	1120948.KB903218_gene1980	4.61e-47	186.0	COG1075@1|root,COG1075@2|Bacteria,2GJGC@201174|Actinobacteria	201174|Actinobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,PGAP1
SRD2_k127_2517065_1	886293.Sinac_6486	4.982e-16	82.0	COG1574@1|root,COG1574@2|Bacteria,2IXY4@203682|Planctomycetes	203682|Planctomycetes	Q	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
SRD2_k127_2517065_0	32057.KB217483_gene10031	7.293e-114	382.0	COG3385@1|root,COG3385@2|Bacteria,1G2W3@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
SRD2_k127_253710_0	590998.Celf_2376	9.891e-44	166.0	COG1321@1|root,COG1321@2|Bacteria,2GK7P@201174|Actinobacteria,4F16U@85016|Cellulomonadaceae	201174|Actinobacteria	K	PFAM iron dependent repressor	sirR	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
SRD2_k127_253710_1	1122221.JHVI01000001_gene1837	2.118e-36	148.0	COG2234@1|root,COG2234@2|Bacteria,1WIK7@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
SRD2_k127_2544034_3	710685.MycrhN_3791	3.078e-25	110.0	COG2867@1|root,COG2867@2|Bacteria,2IIFW@201174|Actinobacteria,23AGI@1762|Mycobacteriaceae	201174|Actinobacteria	I	negative regulation of translational initiation	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
SRD2_k127_2544034_1	479434.Sthe_0104	5.756e-51	193.0	COG4447@1|root,COG4447@2|Bacteria,2G8DW@200795|Chloroflexi,27YX3@189775|Thermomicrobia	189775|Thermomicrobia	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_2544034_2	887062.HGR_07616	5.111e-27	113.0	COG0640@1|root,COG0640@2|Bacteria,1RH5P@1224|Proteobacteria,2VU68@28216|Betaproteobacteria,4AF78@80864|Comamonadaceae	28216|Betaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
SRD2_k127_2544034_4	1227497.C491_21021	3.347e-23	105.0	COG3832@1|root,arCOG05261@2157|Archaea,2XYEH@28890|Euryarchaeota,23WIT@183963|Halobacteria	183963|Halobacteria	S	Activator of Hsp90 ATPase 1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
SRD2_k127_2544034_0	1298880.AUEV01000001_gene5625	5.195e-119	389.0	COG0596@1|root,COG0596@2|Bacteria,2GKT5@201174|Actinobacteria	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
SRD2_k127_2544034_5	439292.Bsel_0278	1.308e-20	96.0	COG0071@1|root,COG0071@2|Bacteria,1VG0E@1239|Firmicutes,4HPDH@91061|Bacilli,26P4P@186821|Sporolactobacillaceae	91061|Bacilli	O	Hsp20/alpha crystallin family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
SRD2_k127_2560316_1	1449353.JQMQ01000005_gene3777	1.643e-76	263.0	COG0300@1|root,COG0300@2|Bacteria,2GNPI@201174|Actinobacteria,2NEU3@228398|Streptacidiphilus	201174|Actinobacteria	S	KR domain	phbB	-	1.1.1.333	ko:K16652	-	-	-	-	ko00000,ko01000	-	-	-	adh_short
SRD2_k127_2560316_0	525904.Tter_1697	8.544e-94	323.0	COG0719@1|root,COG0719@2|Bacteria,2NPGC@2323|unclassified Bacteria	2|Bacteria	O	FeS assembly protein SufD	sufD	GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0040007,GO:0043207,GO:0044085,GO:0044237,GO:0044403,GO:0044419,GO:0050896,GO:0051186,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071840,GO:0075136	-	ko:K07033,ko:K09015	-	-	-	-	ko00000	-	-	iB21_1397.B21_01640,iECBD_1354.ECBD_1964,iECB_1328.ECB_01650,iECD_1391.ECD_01650,iUMNK88_1353.UMNK88_2144	UPF0051
SRD2_k127_2560316_2	324602.Caur_3486	4.591e-19	89.0	COG2146@1|root,COG2146@2|Bacteria,2G7AG@200795|Chloroflexi,375XD@32061|Chloroflexia	32061|Chloroflexia	P	PFAM Rieske 2Fe-2S domain protein	-	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
SRD2_k127_2583497_0	574087.Acear_0053	1.152e-146	482.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1TPA1@1239|Firmicutes,248AU@186801|Clostridia,3WABR@53433|Halanaerobiales	186801|Clostridia	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
SRD2_k127_2583497_1	710111.FraQA3DRAFT_5376	5.569e-54	199.0	COG0084@1|root,COG0084@2|Bacteria,2GMJJ@201174|Actinobacteria,4ES85@85013|Frankiales	201174|Actinobacteria	L	TIGRFAM hydrolase, TatD family	tatD	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
SRD2_k127_2583497_2	1121422.AUMW01000011_gene178	2.539e-43	169.0	COG0030@1|root,COG0030@2|Bacteria,1TP9W@1239|Firmicutes,248RY@186801|Clostridia,2609K@186807|Peptococcaceae	186801|Clostridia	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
SRD2_k127_2583497_3	395961.Cyan7425_0543	6.653e-27	121.0	COG0477@1|root,COG2814@2|Bacteria,1G0DP@1117|Cyanobacteria,3KHHK@43988|Cyanothece	1117|Cyanobacteria	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SRD2_k127_2586107_4	285535.JOEY01000005_gene7808	7.458e-15	81.0	COG1595@1|root,COG1595@2|Bacteria,2HGII@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SRD2_k127_2586107_3	2045.KR76_01090	1.407e-16	93.0	COG5343@1|root,COG5343@2|Bacteria,2I8NI@201174|Actinobacteria,4DQNV@85009|Propionibacteriales	201174|Actinobacteria	S	Anti-sigma-K factor rskA	rskA	-	-	-	-	-	-	-	-	-	-	-	RskA,zf-HC2
SRD2_k127_2586107_1	1382356.JQMP01000003_gene1500	4.268e-36	154.0	COG1595@1|root,COG1595@2|Bacteria,2G6UE@200795|Chloroflexi,27Z8H@189775|Thermomicrobia	189775|Thermomicrobia	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SRD2_k127_2586107_2	1128421.JAGA01000002_gene1613	9.155e-20	94.0	2APF4@1|root,31EHU@2|Bacteria,2NRPN@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF4383)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4383
SRD2_k127_2586107_0	1128421.JAGA01000002_gene1074	8.202e-93	319.0	28HWT@1|root,2Z82P@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Xpo1
SRD2_k127_2599733_12	1120949.KB903326_gene3139	2.084e-12	67.0	COG0346@1|root,COG0346@2|Bacteria,2IG0S@201174|Actinobacteria,4DED6@85008|Micromonosporales	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SRD2_k127_2599733_9	1382359.JIAL01000001_gene3053	1.003e-22	106.0	COG1881@1|root,COG1881@2|Bacteria,3Y5UH@57723|Acidobacteria,2JNWC@204432|Acidobacteriia	204432|Acidobacteriia	S	Phosphatidylethanolamine-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	PBP
SRD2_k127_2599733_4	479432.Sros_7112	1.502e-71	253.0	COG1595@1|root,COG3631@1|root,COG1595@2|Bacteria,COG3631@2|Bacteria,2GKBH@201174|Actinobacteria,4EINU@85012|Streptosporangiales	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2,SnoaL_2
SRD2_k127_2599733_5	1033806.HTIA_1989	2.523e-71	252.0	COG1131@1|root,arCOG00196@2157|Archaea,2Y7M5@28890|Euryarchaeota,24114@183963|Halobacteria	183963|Halobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SRD2_k127_2599733_11	882083.SacmaDRAFT_5231	2.471e-14	84.0	COG0842@1|root,COG0842@2|Bacteria,2GJGH@201174|Actinobacteria,4E037@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
SRD2_k127_2599733_0	1206744.BAGL01000126_gene6244	1.104e-127	424.0	COG0277@1|root,COG0277@2|Bacteria,2GJ33@201174|Actinobacteria,4FUJD@85025|Nocardiaceae	201174|Actinobacteria	C	D-arabinono-1,4-lactone oxidase	-	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005975,GO:0005996,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016051,GO:0016053,GO:0016491,GO:0016627,GO:0016632,GO:0019752,GO:0019852,GO:0019853,GO:0030312,GO:0042364,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046364,GO:0046394,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:0080049,GO:1901576	1.1.3.8	ko:K00103	ko00053,ko01100,map00053,map01100	M00129	R00647,R03184,R10053	RC00195,RC00346,RC00869	ko00000,ko00001,ko00002,ko01000	-	-	-	ALO,FAD_binding_4
SRD2_k127_2599733_2	1123023.JIAI01000002_gene4683	2.518e-119	391.0	COG3616@1|root,COG3616@2|Bacteria,2GK0N@201174|Actinobacteria,4E1C7@85010|Pseudonocardiales	201174|Actinobacteria	E	Putative serine dehydratase domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N,D-ser_dehydrat
SRD2_k127_2599733_6	1123023.JIAI01000003_gene3051	2.419e-56	208.0	COG1090@1|root,COG1090@2|Bacteria,2I3Q5@201174|Actinobacteria,4EEAQ@85010|Pseudonocardiales	201174|Actinobacteria	S	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10
SRD2_k127_2599733_10	743721.Psesu_1609	4.633e-15	88.0	COG3714@1|root,COG3714@2|Bacteria,1N6QN@1224|Proteobacteria,1TAFV@1236|Gammaproteobacteria,1X74T@135614|Xanthomonadales	135614|Xanthomonadales	S	YhhN family	-	-	-	-	-	-	-	-	-	-	-	-	YhhN
SRD2_k127_2599733_7	266117.Rxyl_1966	1.745e-55	208.0	COG0382@1|root,COG0382@2|Bacteria,2GJ6P@201174|Actinobacteria,4CTED@84995|Rubrobacteria	84995|Rubrobacteria	H	UbiA prenyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	UbiA
SRD2_k127_2599733_8	479434.Sthe_1714	3.934e-42	168.0	COG0438@1|root,COG0438@2|Bacteria,2G5N9@200795|Chloroflexi,27XSF@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SRD2_k127_2599733_3	365528.KB891233_gene1748	4.871e-77	265.0	COG1051@1|root,COG4111@1|root,COG1051@2|Bacteria,COG4111@2|Bacteria,2GNMT@201174|Actinobacteria,4EV0Y@85013|Frankiales	201174|Actinobacteria	F	PFAM NUDIX hydrolase	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
SRD2_k127_2599733_1	479434.Sthe_0863	1.974e-124	411.0	COG0379@1|root,COG0379@2|Bacteria,2G64Y@200795|Chloroflexi,27Z0R@189775|Thermomicrobia	189775|Thermomicrobia	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
SRD2_k127_2693978_3	1183438.GKIL_2340	1.176e-09	70.0	COG1376@1|root,COG1376@2|Bacteria,1G4ZS@1117|Cyanobacteria	1117|Cyanobacteria	S	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
SRD2_k127_2693978_2	1268303.RHODMAR_0235	1.551e-14	87.0	COG5650@1|root,COG5650@2|Bacteria,2GJBC@201174|Actinobacteria,4FXA8@85025|Nocardiaceae	201174|Actinobacteria	S	Glycosyltransferase family 87	-	-	-	ko:K13671	-	-	-	-	ko00000,ko01000,ko01003	-	GT87	-	GT87
SRD2_k127_2693978_0	309801.trd_0376	1.804e-27	116.0	COG2151@1|root,COG2151@2|Bacteria,2G75C@200795|Chloroflexi,27YH9@189775|Thermomicrobia	189775|Thermomicrobia	S	Pfam:DUF59	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
SRD2_k127_2693978_1	1089548.KI783301_gene2645	1.528e-22	99.0	COG0822@1|root,COG0822@2|Bacteria,1V3H9@1239|Firmicutes,4HIJ0@91061|Bacilli,3WESX@539002|Bacillales incertae sedis	91061|Bacilli	C	SUF system FeS assembly protein, NifU family	nifU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
SRD2_k127_2694004_3	1183438.GKIL_2340	6.004e-08	65.0	COG1376@1|root,COG1376@2|Bacteria,1G4ZS@1117|Cyanobacteria	1117|Cyanobacteria	S	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
SRD2_k127_2694004_2	1206741.BAFX01000074_gene4394	3.55e-15	89.0	COG5650@1|root,COG5650@2|Bacteria,2GJBC@201174|Actinobacteria,4FX2G@85025|Nocardiaceae	201174|Actinobacteria	S	Glycosyltransferase family 87	-	-	-	ko:K13671	-	-	-	-	ko00000,ko01000,ko01003	-	GT87	-	GT87
SRD2_k127_2694004_0	309801.trd_0376	5.815e-28	116.0	COG2151@1|root,COG2151@2|Bacteria,2G75C@200795|Chloroflexi,27YH9@189775|Thermomicrobia	189775|Thermomicrobia	S	Pfam:DUF59	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
SRD2_k127_2694004_1	1089548.KI783301_gene2645	2.879e-22	98.0	COG0822@1|root,COG0822@2|Bacteria,1V3H9@1239|Firmicutes,4HIJ0@91061|Bacilli,3WESX@539002|Bacillales incertae sedis	91061|Bacilli	C	SUF system FeS assembly protein, NifU family	nifU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
SRD2_k127_2707663_10	298654.FraEuI1c_0463	3.771e-28	128.0	2DBRF@1|root,2ZAKB@2|Bacteria,2IIVX@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_2707663_0	469383.Cwoe_1001	8.213e-103	342.0	COG0300@1|root,COG0300@2|Bacteria,2IIVW@201174|Actinobacteria,4CT0F@84995|Rubrobacteria	84995|Rubrobacteria	S	Fungal family of unknown function (DUF1776)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SRD2_k127_2707663_6	1120973.AQXL01000088_gene3242	8.42e-47	180.0	COG0697@1|root,COG0697@2|Bacteria,1TR6G@1239|Firmicutes,4HAMD@91061|Bacilli,278BW@186823|Alicyclobacillaceae	91061|Bacilli	EG	EamA-like transporter family	ydeD	-	-	-	-	-	-	-	-	-	-	-	EamA
SRD2_k127_2707663_4	196162.Noca_2635	1.017e-61	223.0	COG2197@1|root,COG2197@2|Bacteria,2GJKM@201174|Actinobacteria,4DQZM@85009|Propionibacteriales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
SRD2_k127_2707663_2	1122939.ATUD01000001_gene551	4.215e-82	289.0	COG4585@1|root,COG4585@2|Bacteria,2IAG1@201174|Actinobacteria,4CR3I@84995|Rubrobacteria	84995|Rubrobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
SRD2_k127_2707663_1	1120950.KB892707_gene4619	9.366e-100	336.0	COG1793@1|root,COG1793@2|Bacteria,2IKE5@201174|Actinobacteria	201174|Actinobacteria	L	dna ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
SRD2_k127_2707663_7	485913.Krac_1375	7.065e-43	169.0	COG0834@1|root,COG0834@2|Bacteria,2G7BD@200795|Chloroflexi	200795|Chloroflexi	ET	COGs COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
SRD2_k127_2707663_8	1120972.AUMH01000020_gene2159	2.839e-42	166.0	COG1307@1|root,COG1307@2|Bacteria,1TRM7@1239|Firmicutes,4HBIR@91061|Bacilli,279B8@186823|Alicyclobacillaceae	91061|Bacilli	S	Uncharacterised protein, DegV family COG1307	degV	-	-	-	-	-	-	-	-	-	-	-	DegV
SRD2_k127_2707663_3	1521187.JPIM01000028_gene1594	1.92e-80	275.0	COG0745@1|root,COG0745@2|Bacteria,2G6JT@200795|Chloroflexi	200795|Chloroflexi	K	Two component transcriptional regulator, winged helix family	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
SRD2_k127_2707663_5	1521187.JPIM01000028_gene1595	9.104e-61	225.0	COG3850@1|root,COG5002@1|root,COG3850@2|Bacteria,COG5002@2|Bacteria,2G60Q@200795|Chloroflexi	200795|Chloroflexi	T	histidine kinase HAMP region domain protein	-	-	2.7.13.3	ko:K02484,ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
SRD2_k127_2707663_9	28444.JODQ01000001_gene2427	8.293e-30	123.0	COG2197@1|root,COG2197@2|Bacteria,2INZX@201174|Actinobacteria	201174|Actinobacteria	T	Pfam Response regulator receiver	-	-	-	ko:K07689	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
SRD2_k127_2707663_11	35754.JNYJ01000029_gene9509	2.627e-18	92.0	COG2197@1|root,COG2197@2|Bacteria,2IIDD@201174|Actinobacteria,4DJ23@85008|Micromonosporales	201174|Actinobacteria	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
SRD2_k127_2767216_3	1197906.CAJQ02000011_gene835	2.273e-11	66.0	COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,2TUXD@28211|Alphaproteobacteria,3JSP8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	enoyl-CoA hydratase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
SRD2_k127_2767216_2	675635.Psed_6504	1.83e-34	145.0	COG0494@1|root,COG0494@2|Bacteria,2GN6D@201174|Actinobacteria,4DXPE@85010|Pseudonocardiales	201174|Actinobacteria	L	pfam nudix	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
SRD2_k127_2767216_1	190650.CC_0923	3.722e-53	199.0	COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,2TUAZ@28211|Alphaproteobacteria,2KFMD@204458|Caulobacterales	204458|Caulobacterales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SRD2_k127_2767216_0	867903.ThesuDRAFT_01778	4.332e-89	300.0	COG0761@1|root,COG0761@2|Bacteria,1UHT7@1239|Firmicutes,25E67@186801|Clostridia,3WDRU@538999|Clostridiales incertae sedis	186801|Clostridia	H	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K02945,ko:K03527	ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010	M00096,M00178	R05884,R08210	RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011	-	-	-	LYTB
SRD2_k127_2995090_2	240015.ACP_1838	1.395e-27	113.0	COG2128@1|root,COG2128@2|Bacteria,3Y4TK@57723|Acidobacteria,2JJJ6@204432|Acidobacteriia	204432|Acidobacteriia	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
SRD2_k127_2995090_1	479434.Sthe_0632	1.095e-101	353.0	COG0122@1|root,COG0122@2|Bacteria,2G8TI@200795|Chloroflexi,27YWG@189775|Thermomicrobia	189775|Thermomicrobia	L	endonuclease III	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
SRD2_k127_2995090_0	697282.Mettu_0616	6.039e-176	559.0	COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,1RN6P@1236|Gammaproteobacteria,1XEW5@135618|Methylococcales	135618|Methylococcales	C	Apoptosis-inducing factor, mitochondrion-associated, C-term	-	-	-	-	-	-	-	-	-	-	-	-	AIF_C,Pyr_redox_2
SRD2_k127_2997351_14	645465.ACUR01000355_gene3248	6.317e-09	64.0	2B7W2@1|root,3212Y@2|Bacteria,2H4ZW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_2997351_6	243924.LT42_15125	3.28e-63	248.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,dCache_3
SRD2_k127_2997351_3	205918.Psyr_2881	1.257e-97	325.0	COG4870@1|root,COG4870@2|Bacteria,1MV6S@1224|Proteobacteria,1S02V@1236|Gammaproteobacteria,1Z6BR@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	O	Papain cysteine protease family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C1
SRD2_k127_2997351_12	1232410.KI421428_gene1209	1.274e-16	89.0	COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,42MWD@68525|delta/epsilon subdivisions,2WMG9@28221|Deltaproteobacteria,43TF2@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Inhibitor of apoptosis-promoting Bax1	ybhL	-	-	ko:K06890,ko:K19416	-	M00742	-	-	ko00000,ko00002,ko02000	1.A.14.2.1	-	-	Bax1-I
SRD2_k127_2997351_5	1449976.KALB_182	1.175e-64	229.0	COG0730@1|root,COG0730@2|Bacteria,2GJCC@201174|Actinobacteria,4DYGM@85010|Pseudonocardiales	201174|Actinobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
SRD2_k127_2997351_11	272134.KB731324_gene2658	4.641e-17	93.0	2EWB1@1|root,33PPS@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_42
SRD2_k127_2997351_2	309801.trd_0859	1.844e-101	341.0	COG3892@1|root,COG3892@2|Bacteria,2G87A@200795|Chloroflexi,27Z2I@189775|Thermomicrobia	189775|Thermomicrobia	G	Uncharacterized protein conserved in bacteria (DUF2090)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2090
SRD2_k127_2997351_13	1173028.ANKO01000140_gene632	3.044e-13	79.0	COG0745@1|root,COG2114@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,1FZXP@1117|Cyanobacteria,1H9FJ@1150|Oscillatoriales	1117|Cyanobacteria	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Response_reg
SRD2_k127_2997351_0	258533.BN977_03174	5.131e-219	689.0	COG0160@1|root,COG0160@2|Bacteria,2I2F3@201174|Actinobacteria,2356J@1762|Mycobacteriaceae	201174|Actinobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.55	ko:K15372	ko00410,ko00430,ko01100,map00410,map00430,map01100	-	R00908,R01684	RC00006,RC00062	ko00000,ko00001,ko01000	-	-	-	Aminotran_3
SRD2_k127_2997351_4	646529.Desaci_0968	4.401e-84	290.0	COG0387@1|root,COG0387@2|Bacteria,1TQN2@1239|Firmicutes,248J3@186801|Clostridia,2606E@186807|Peptococcaceae	186801|Clostridia	P	PFAM Sodium calcium exchanger protein	cax	-	-	ko:K07300	-	-	-	-	ko00000,ko02000	2.A.19	-	-	Na_Ca_ex
SRD2_k127_2997351_8	266117.Rxyl_3141	1.594e-35	149.0	COG0589@1|root,COG0589@2|Bacteria,2GSJK@201174|Actinobacteria,4CQXK@84995|Rubrobacteria	201174|Actinobacteria	T	COG COG0589 Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms	uspA2	-	-	-	-	-	-	-	-	-	-	-	Usp
SRD2_k127_2997351_10	471852.Tcur_0705	7.398e-23	104.0	COG0517@1|root,COG0517@2|Bacteria,2I26I@201174|Actinobacteria,4EQHS@85012|Streptosporangiales	201174|Actinobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SRD2_k127_2997351_7	1157637.KB892091_gene5414	3.503e-42	171.0	COG0517@1|root,COG0517@2|Bacteria,2GKSH@201174|Actinobacteria	201174|Actinobacteria	C	Cbs domain	-	-	-	-	-	-	-	-	-	-	-	-	BON,CBS
SRD2_k127_2997351_1	479432.Sros_4837	2.34e-133	440.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,2GM3U@201174|Actinobacteria,4EHKU@85012|Streptosporangiales	201174|Actinobacteria	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
SRD2_k127_2997351_9	68194.JNXR01000048_gene2026	5.036e-28	127.0	COG0517@1|root,COG0517@2|Bacteria,2IEKD@201174|Actinobacteria	201174|Actinobacteria	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON,CBS
SRD2_k127_3021913_23	765420.OSCT_2772	1.024e-30	127.0	COG2001@1|root,COG2001@2|Bacteria,2G6ZC@200795|Chloroflexi,3778H@32061|Chloroflexia	32061|Chloroflexia	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
SRD2_k127_3021913_10	338963.Pcar_2210	1.56e-81	284.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,42N5Q@68525|delta/epsilon subdivisions,2WJ8J@28221|Deltaproteobacteria,43SBK@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	MraW methylase family	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
SRD2_k127_3021913_33	66875.JODY01000015_gene651	2.246e-05	53.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,2GJGR@201174|Actinobacteria	201174|Actinobacteria	L	ComEC Rec2-related protein	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
SRD2_k127_3021913_5	525904.Tter_1614	1.065e-103	358.0	COG0768@1|root,COG0768@2|Bacteria,2NNWR@2323|unclassified Bacteria	2|Bacteria	M	Penicillin-binding Protein dimerisation domain	ftsI	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681	3.4.16.4	ko:K03587,ko:K08384	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	iSSON_1240.SSON_0092	PASTA,PBP_dimer,Transpeptidase
SRD2_k127_3021913_9	644966.Tmar_0866	5.284e-90	325.0	COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,25100@186801|Clostridia,3WCHQ@538999|Clostridiales incertae sedis	186801|Clostridia	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
SRD2_k127_3021913_17	562970.Btus_1860	6.504e-50	194.0	COG0472@1|root,COG0472@2|Bacteria,1TP8W@1239|Firmicutes,4H9TP@91061|Bacilli,277XP@186823|Alicyclobacillaceae	91061|Bacilli	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
SRD2_k127_3021913_8	484770.UFO1_2516	7.309e-95	331.0	COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,4H3RE@909932|Negativicutes	909932|Negativicutes	D	TIGRFAM stage V sporulation protein E, cell division protein FtsW	-	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
SRD2_k127_3021913_15	1121468.AUBR01000006_gene364	2.867e-61	224.0	COG0707@1|root,COG0707@2|Bacteria,1TQFT@1239|Firmicutes,248IA@186801|Clostridia,42F8I@68295|Thermoanaerobacterales	186801|Clostridia	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
SRD2_k127_3021913_7	1121020.JIAG01000002_gene728	3.771e-95	338.0	COG0773@1|root,COG0773@2|Bacteria,2I2E7@201174|Actinobacteria,1W7MP@1268|Micrococcaceae	201174|Actinobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
SRD2_k127_3021913_14	357808.RoseRS_3790	2.508e-61	237.0	COG0812@1|root,COG0812@2|Bacteria,2G6H3@200795|Chloroflexi,3754P@32061|Chloroflexia	32061|Chloroflexia	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
SRD2_k127_3021913_12	1089553.Tph_c13150	2.545e-76	271.0	COG1181@1|root,COG1181@2|Bacteria,1TP2Y@1239|Firmicutes,248CR@186801|Clostridia,42EYR@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
SRD2_k127_3021913_32	235909.GK1120	1.186e-08	66.0	COG1589@1|root,COG1589@2|Bacteria,1V6V5@1239|Firmicutes,4HDFD@91061|Bacilli,1WE3P@129337|Geobacillus	91061|Bacilli	D	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex	divIB	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
SRD2_k127_3021913_24	429009.Adeg_1556	6.54e-28	123.0	COG3856@1|root,COG3856@2|Bacteria,1VA6N@1239|Firmicutes,24N58@186801|Clostridia,42GSD@68295|Thermoanaerobacterales	186801|Clostridia	S	small basic protein	sbp	-	-	-	-	-	-	-	-	-	-	-	DUF1290
SRD2_k127_3021913_4	1382306.JNIM01000001_gene41	1.058e-117	393.0	COG0849@1|root,COG0849@2|Bacteria,2G5V5@200795|Chloroflexi	200795|Chloroflexi	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
SRD2_k127_3021913_2	555088.DealDRAFT_1341	6.993e-131	431.0	COG0206@1|root,COG0206@2|Bacteria,1TP6W@1239|Firmicutes,247Z5@186801|Clostridia,42JIC@68298|Syntrophomonadaceae	186801|Clostridia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
SRD2_k127_3021913_16	1121430.JMLG01000003_gene603	5.012e-53	191.0	COG1327@1|root,COG1327@2|Bacteria,1V3JA@1239|Firmicutes,24HFT@186801|Clostridia,261UI@186807|Peptococcaceae	186801|Clostridia	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
SRD2_k127_3021913_25	604331.AUHY01000005_gene776	6.867e-28	126.0	COG1496@1|root,COG1496@2|Bacteria,1WI9I@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Belongs to the multicopper oxidase YfiH RL5 family	-	GO:0003674,GO:0005488,GO:0005507,GO:0043167,GO:0043169,GO:0046872,GO:0046914	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
SRD2_k127_3021913_20	383372.Rcas_3740	1.385e-45	179.0	COG0325@1|root,COG0325@2|Bacteria,2G6F1@200795|Chloroflexi,375I2@32061|Chloroflexia	32061|Chloroflexia	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
SRD2_k127_3021913_31	269799.Gmet_1166	1.011e-10	66.0	COG0762@1|root,COG0762@2|Bacteria,1QDB9@1224|Proteobacteria,42VCU@68525|delta/epsilon subdivisions,2WRHX@28221|Deltaproteobacteria,43VQH@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	YGGT family	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
SRD2_k127_3021913_0	926569.ANT_22850	3.538e-311	982.0	COG0060@1|root,COG0060@2|Bacteria,2G5SN@200795|Chloroflexi	200795|Chloroflexi	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
SRD2_k127_3021913_3	866895.HBHAL_5002	4.161e-120	398.0	COG1304@1|root,COG1304@2|Bacteria,1TPC4@1239|Firmicutes,4HAU5@91061|Bacilli	91061|Bacilli	C	L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases	lctO	-	1.13.12.4	ko:K00467,ko:K10530	ko00620,map00620	-	R00319	RC01312	ko00000,ko00001,ko01000	-	-	-	FMN_dh
SRD2_k127_3021913_27	357808.RoseRS_0256	6.117e-19	92.0	COG1734@1|root,COG1734@2|Bacteria,2G7BM@200795|Chloroflexi,377WS@32061|Chloroflexia	32061|Chloroflexia	K	PFAM zinc finger, DksA TraR C4-type	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
SRD2_k127_3021913_26	498761.HM1_2103	1.412e-27	117.0	COG0597@1|root,COG0597@2|Bacteria,1VA9R@1239|Firmicutes,24QPP@186801|Clostridia	186801|Clostridia	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
SRD2_k127_3021913_11	1521187.JPIM01000065_gene1258	4.309e-77	274.0	COG0564@1|root,COG0564@2|Bacteria,2G68N@200795|Chloroflexi,3758V@32061|Chloroflexia	32061|Chloroflexia	J	Responsible for synthesis of pseudouridine from uracil	-	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
SRD2_k127_3021913_18	1125712.HMPREF1316_1759	9.819e-49	185.0	COG0194@1|root,COG0194@2|Bacteria,2GK2M@201174|Actinobacteria,4CVKY@84998|Coriobacteriia	84998|Coriobacteriia	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
SRD2_k127_3021913_6	264732.Moth_0893	5.281e-100	343.0	COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,247J3@186801|Clostridia,42FF1@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
SRD2_k127_3021913_22	592015.HMPREF1705_01914	1.072e-40	164.0	COG1192@1|root,COG1192@2|Bacteria,3T9TR@508458|Synergistetes	508458|Synergistetes	D	CobQ CobB MinD ParA nucleotide binding domain	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
SRD2_k127_3021913_1	1121468.AUBR01000005_gene29	4.544e-147	490.0	COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,248EI@186801|Clostridia,42EMV@68295|Thermoanaerobacterales	186801|Clostridia	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
SRD2_k127_3021913_30	1198676.SMUGS5_00090	4.342e-15	87.0	COG3883@1|root,COG3942@1|root,COG3883@2|Bacteria,COG3942@2|Bacteria,1UZ12@1239|Firmicutes,4HCUD@91061|Bacilli	91061|Bacilli	M	CHAP domain protein	usp	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	CHAP,NLPC_P60
SRD2_k127_3021913_19	1382306.JNIM01000001_gene4145	5.254e-47	180.0	COG0242@1|root,COG0242@2|Bacteria,2G6VE@200795|Chloroflexi	200795|Chloroflexi	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
SRD2_k127_3021913_13	795359.TOPB45_1007	1.23e-69	248.0	COG0223@1|root,COG0223@2|Bacteria,2GGW2@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
SRD2_k127_3021913_21	477974.Daud_0256	4.982e-43	175.0	COG0691@1|root,COG0691@2|Bacteria,1V3IJ@1239|Firmicutes,24HD6@186801|Clostridia,261PA@186807|Peptococcaceae	186801|Clostridia	J	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
SRD2_k127_3021913_29	485913.Krac_2293	1.597e-15	89.0	COG3340@1|root,COG3340@2|Bacteria	2|Bacteria	E	Belongs to the peptidase S51 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S51
SRD2_k127_3021913_28	584708.Apau_1014	6.825e-18	95.0	COG0484@1|root,COG0484@2|Bacteria,3TAAF@508458|Synergistetes	508458|Synergistetes	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
SRD2_k127_3034659_6	671143.DAMO_1095	3.364e-47	177.0	COG1392@1|root,COG1392@2|Bacteria,2NPPV@2323|unclassified Bacteria	2|Bacteria	P	Protein of unknown function DUF47	MA20_27875	-	-	ko:K02039,ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
SRD2_k127_3034659_3	351607.Acel_2027	1.456e-92	314.0	COG0306@1|root,COG0306@2|Bacteria,2GJHK@201174|Actinobacteria,4ERKR@85013|Frankiales	201174|Actinobacteria	P	phosphate transporter	pit	GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	iNJ661.Rv0545c,iNJ661.Rv2281	PHO4
SRD2_k127_3034659_4	1146883.BLASA_4090	7.218e-92	321.0	COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria,4ESA1@85013|Frankiales	201174|Actinobacteria	Q	Belongs to the long-chain O-acyltransferase family	tgs3	GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0004144,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0030312,GO:0036293,GO:0040007,GO:0042221,GO:0042493,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044464,GO:0045017,GO:0046460,GO:0046463,GO:0046486,GO:0047196,GO:0050896,GO:0051704,GO:0070482,GO:0071704,GO:0071731,GO:0071944,GO:0097366,GO:1901576,GO:1901698,GO:1901700	2.3.1.20	ko:K00635	ko00561,ko01100,map00561,map01100	M00089	R02251	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1298,WES_acyltransf
SRD2_k127_3034659_1	1122611.KB903993_gene7342	1.343e-117	390.0	COG0673@1|root,COG0673@2|Bacteria,2GN2Z@201174|Actinobacteria,4EHEP@85012|Streptosporangiales	201174|Actinobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	ydgJ	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SRD2_k127_3034659_5	1449346.JQMO01000003_gene2639	3.296e-68	248.0	COG0265@1|root,COG0265@2|Bacteria,2GJJ3@201174|Actinobacteria,2M53I@2063|Kitasatospora	201174|Actinobacteria	O	PDZ domain (Also known as DHR or GLGF)	pepA	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
SRD2_k127_3034659_2	526225.Gobs_2337	3.984e-114	370.0	COG0262@1|root,COG0262@2|Bacteria,2GMZV@201174|Actinobacteria,4ERHX@85013|Frankiales	201174|Actinobacteria	H	PFAM bifunctional deaminase-reductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
SRD2_k127_3034659_0	309801.trd_0110	5.11e-124	406.0	COG2876@1|root,COG2876@2|Bacteria,2G643@200795|Chloroflexi,27XKF@189775|Thermomicrobia	189775|Thermomicrobia	E	NeuB family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
SRD2_k127_3034659_7	1283299.AUKG01000001_gene3097	4.077e-36	145.0	COG3461@1|root,COG3461@2|Bacteria,2GZN9@201174|Actinobacteria,4CSVG@84995|Rubrobacteria	84995|Rubrobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_3034659_8	1464048.JNZS01000042_gene962	1.483e-15	83.0	COG1846@1|root,COG1846@2|Bacteria,2IHQU@201174|Actinobacteria,4DEAG@85008|Micromonosporales	201174|Actinobacteria	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
SRD2_k127_3071842_4	1122947.FR7_3606	1.495e-60	223.0	COG1559@1|root,COG1559@2|Bacteria,1TS48@1239|Firmicutes,4H20Z@909932|Negativicutes	909932|Negativicutes	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
SRD2_k127_3071842_6	546271.Selsp_1868	8.634e-49	184.0	COG0169@1|root,COG0169@2|Bacteria,1TQRY@1239|Firmicutes,4H2Y2@909932|Negativicutes	909932|Negativicutes	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
SRD2_k127_3071842_14	1146883.BLASA_2005	7.668e-13	81.0	COG1989@1|root,COG1989@2|Bacteria,2GJ7K@201174|Actinobacteria,4ESYI@85013|Frankiales	201174|Actinobacteria	NOU	peptidase A24A prepilin type IV	-	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	Peptidase_A24
SRD2_k127_3071842_13	525909.Afer_0600	1.613e-13	77.0	COG3428@1|root,COG3428@2|Bacteria,2HGDA@201174|Actinobacteria,4CNBH@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	SHOCT,bPH_2
SRD2_k127_3071842_0	555088.DealDRAFT_1398	1.022e-121	409.0	COG0082@1|root,COG0082@2|Bacteria,1TQ40@1239|Firmicutes,24998@186801|Clostridia,42JS5@68298|Syntrophomonadaceae	186801|Clostridia	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
SRD2_k127_3071842_10	269799.Gmet_0977	4.6e-28	121.0	COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,42WJW@68525|delta/epsilon subdivisions,2WRIA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
SRD2_k127_3071842_2	1384054.N790_07795	1.032e-74	269.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1X42C@135614|Xanthomonadales	135614|Xanthomonadales	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
SRD2_k127_3071842_9	1040989.AWZU01000019_gene1946	3.815e-39	150.0	COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,2U9BV@28211|Alphaproteobacteria,3JY37@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
SRD2_k127_3071842_3	644966.Tmar_1186	7.081e-62	227.0	COG0231@1|root,COG0231@2|Bacteria,1TR8P@1239|Firmicutes,249DV@186801|Clostridia,3WCHF@538999|Clostridiales incertae sedis	186801|Clostridia	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
SRD2_k127_3071842_15	526218.Sterm_1750	1.855e-09	64.0	COG1302@1|root,COG1302@2|Bacteria,37AEJ@32066|Fusobacteria	32066|Fusobacteria	S	Asp23 family, cell envelope-related function	-	-	-	-	-	-	-	-	-	-	-	-	Asp23
SRD2_k127_3071842_11	696281.Desru_3077	8.967e-27	122.0	COG0781@1|root,COG0781@2|Bacteria,1VA9B@1239|Firmicutes,24MQ3@186801|Clostridia,26201@186807|Peptococcaceae	186801|Clostridia	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
SRD2_k127_3071842_1	292459.STH1846	3.827e-89	309.0	COG1570@1|root,COG1570@2|Bacteria,1TP4E@1239|Firmicutes,247KE@186801|Clostridia	186801|Clostridia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
SRD2_k127_3071842_12	663610.JQKO01000008_gene119	3.938e-14	76.0	COG1722@1|root,COG1722@2|Bacteria,1PTYQ@1224|Proteobacteria,2UFD6@28211|Alphaproteobacteria,3NBFR@45404|Beijerinckiaceae	28211|Alphaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
SRD2_k127_3071842_8	857293.CAAU_2501	1.54e-39	155.0	COG1963@1|root,COG1963@2|Bacteria,1VAVC@1239|Firmicutes,24MV7@186801|Clostridia,36KSA@31979|Clostridiaceae	186801|Clostridia	S	Divergent PAP2 family	-	-	-	ko:K09775	-	-	-	-	ko00000	-	-	-	DUF212
SRD2_k127_3071842_5	292564.Cyagr_3066	2.457e-60	226.0	COG1189@1|root,COG1189@2|Bacteria,1G001@1117|Cyanobacteria,22TBV@167375|Cyanobium	1117|Cyanobacteria	J	FtsJ-like methyltransferase	tly	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
SRD2_k127_3071842_7	1123371.ATXH01000005_gene2057	1.059e-42	169.0	COG0061@1|root,COG0061@2|Bacteria,2GHQS@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
SRD2_k127_3071842_16	525904.Tter_0820	4.174e-07	61.0	COG2206@1|root,COG2206@2|Bacteria	2|Bacteria	T	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K07012	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HD,Helicase_C
SRD2_k127_3071842_17	653045.Strvi_6853	2.442e-05	53.0	COG1354@1|root,COG1354@2|Bacteria,2GN1U@201174|Actinobacteria	201174|Actinobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
SRD2_k127_3072628_10	1484479.DI14_01945	1.525e-23	102.0	COG0761@1|root,COG0761@2|Bacteria,1UHT7@1239|Firmicutes,4H9S4@91061|Bacilli,3WF5S@539002|Bacillales incertae sedis	91061|Bacilli	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
SRD2_k127_3072628_0	635013.TherJR_2560	1.01e-233	748.0	COG0466@1|root,COG0466@2|Bacteria,1TNYG@1239|Firmicutes,247SH@186801|Clostridia,260BY@186807|Peptococcaceae	186801|Clostridia	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
SRD2_k127_3072628_12	710696.Intca_2933	9.755e-19	93.0	2AZ39@1|root,31R9K@2|Bacteria,2GMCY@201174|Actinobacteria,4FGHN@85021|Intrasporangiaceae	201174|Actinobacteria	S	Putative bacterial sensory transduction regulator	-	-	-	-	-	-	-	-	-	-	-	-	YbjN
SRD2_k127_3072628_6	1254432.SCE1572_30035	1.74e-67	234.0	COG3576@1|root,COG3576@2|Bacteria,1R8RC@1224|Proteobacteria,430PA@68525|delta/epsilon subdivisions,2WZ68@28221|Deltaproteobacteria,2Z1EX@29|Myxococcales	28221|Deltaproteobacteria	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
SRD2_k127_3072628_3	1382306.JNIM01000001_gene2733	5.972e-91	309.0	COG2025@1|root,COG2025@2|Bacteria,2G6PP@200795|Chloroflexi	200795|Chloroflexi	C	electron transfer flavoprotein, alpha subunit	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
SRD2_k127_3072628_7	471852.Tcur_3575	1.625e-64	230.0	COG2086@1|root,COG2086@2|Bacteria,2GKV6@201174|Actinobacteria,4EFT7@85012|Streptosporangiales	201174|Actinobacteria	C	Electron transfer flavoprotein domain	etfB	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016020,GO:0016491,GO:0022900,GO:0030312,GO:0040007,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
SRD2_k127_3072628_14	1232428.CAVO010000048_gene2282	1.363e-05	56.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
SRD2_k127_3072628_2	204669.Acid345_0779	4.394e-121	409.0	COG1793@1|root,COG1793@2|Bacteria,3Y2VV@57723|Acidobacteria,2JIJ7@204432|Acidobacteriia	204432|Acidobacteriia	L	DNA ligase D, 3'-phosphoesterase domain	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
SRD2_k127_3072628_9	326424.FRAAL4382	2.01e-53	202.0	COG1793@1|root,COG1793@2|Bacteria,2IKE5@201174|Actinobacteria,4ESAR@85013|Frankiales	201174|Actinobacteria	L	DNA polymerase LigD, ligase domain protein	ligD	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
SRD2_k127_3072628_8	1445613.JALM01000001_gene3189	1.897e-63	228.0	COG1273@1|root,COG1273@2|Bacteria,2GJMU@201174|Actinobacteria,4E10U@85010|Pseudonocardiales	201174|Actinobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
SRD2_k127_3072628_5	485913.Krac_6502	1.138e-72	256.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Big_3_3,LTD,PKD,Pro-kuma_activ,fn3
SRD2_k127_3072628_1	1123024.AUII01000012_gene4103	1.181e-180	587.0	COG1960@1|root,COG1960@2|Bacteria,2GKQI@201174|Actinobacteria,4E0PU@85010|Pseudonocardiales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SRD2_k127_3072628_4	931627.MycrhDRAFT_1689	5.25e-85	291.0	COG3173@1|root,COG3173@2|Bacteria,2GNNV@201174|Actinobacteria,235T8@1762|Mycobacteriaceae	201174|Actinobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
SRD2_k127_3072628_11	1214101.BN159_8033	5.769e-20	97.0	COG0406@1|root,COG0406@2|Bacteria	2|Bacteria	G	alpha-ribazole phosphatase activity	mutT	-	3.1.3.73,3.6.1.55,5.4.2.11,5.4.2.12	ko:K01834,ko:K02226,ko:K03574,ko:K15634	ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003,M00122	R01518,R04594,R11173	RC00017,RC00536	ko00000,ko00001,ko00002,ko01000,ko03400,ko04131,ko04147	-	-	-	His_Phos_1,NUDIX
SRD2_k127_3072628_13	1150474.JQJI01000054_gene1401	3.21e-18	90.0	COG2050@1|root,COG2050@2|Bacteria	2|Bacteria	Q	thiolester hydrolase activity	-	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	4HBT
SRD2_k127_3075192_1	1121121.KB894302_gene853	2.161e-38	147.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1TQ0B@1239|Firmicutes,4HA4G@91061|Bacilli,26RAZ@186822|Paenibacillaceae	91061|Bacilli	E	Glutamate synthase	gltA2	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
SRD2_k127_3075192_0	1229780.BN381_500017	2.405e-70	243.0	COG0500@1|root,COG2226@2|Bacteria,2HFQC@201174|Actinobacteria,3UXKF@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
SRD2_k127_3079140_1	448385.sce1895	5.617e-08	56.0	2EEHD@1|root,338B8@2|Bacteria,1R0C1@1224|Proteobacteria,42W5S@68525|delta/epsilon subdivisions,2WRR5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_3079140_0	105425.BBPL01000056_gene5545	8.032e-22	111.0	COG3385@1|root,COG3385@2|Bacteria,2GKQB@201174|Actinobacteria,2NIQ3@228398|Streptacidiphilus	201174|Actinobacteria	L	Insertion element 4 transposase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,Nterm_IS4
SRD2_k127_3136923_0	1111479.AXAR01000004_gene2205	2.752e-75	278.0	COG3391@1|root,COG3511@1|root,COG3391@2|Bacteria,COG3511@2|Bacteria,1V255@1239|Firmicutes,4HFUF@91061|Bacilli	91061|Bacilli	M	40-residue YVTN family beta-propeller repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,Cytochrom_D1,Lactonase,Phosphoesterase
SRD2_k127_3136923_2	469383.Cwoe_4056	1.933e-21	104.0	COG3467@1|root,COG3467@2|Bacteria,2I2X2@201174|Actinobacteria,4CU4F@84995|Rubrobacteria	84995|Rubrobacteria	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
SRD2_k127_3136923_1	1382356.JQMP01000003_gene1516	7.797e-50	191.0	COG0726@1|root,COG0726@2|Bacteria,2G6VJ@200795|Chloroflexi,27Y6A@189775|Thermomicrobia	189775|Thermomicrobia	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
SRD2_k127_3136923_3	243090.RB6533	3.114e-09	61.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,2IXNF@203682|Planctomycetes	203682|Planctomycetes	I	AMP-dependent synthetase and ligase	-	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding,Acyltransferase,MFS_1
SRD2_k127_314726_5	2045.KR76_25255	0.0001934	53.0	COG4932@1|root,COG4932@2|Bacteria,2GXWA@201174|Actinobacteria,4DUCA@85009|Propionibacteriales	201174|Actinobacteria	M	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	B_lectin,CarboxypepD_reg,Peptidase_M23,SASA
SRD2_k127_314726_3	68170.KL590532_gene2720	1.049e-38	165.0	COG1835@1|root,COG1835@2|Bacteria,2GKUS@201174|Actinobacteria,4E1PA@85010|Pseudonocardiales	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
SRD2_k127_314726_0	255470.cbdbA734	1.332e-79	274.0	arCOG06481@1|root,2ZB4E@2|Bacteria,2G82Q@200795|Chloroflexi,34CXZ@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_314726_4	1227261.HMPREF0043_01017	4.518e-06	54.0	COG1917@1|root,COG1917@2|Bacteria,2HMQ9@201174|Actinobacteria,4D7DC@85005|Actinomycetales	201174|Actinobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_314726_1	1380390.JIAT01000010_gene3637	5.459e-63	228.0	COG1752@1|root,COG1752@2|Bacteria,2IB0F@201174|Actinobacteria,4CR75@84995|Rubrobacteria	84995|Rubrobacteria	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
SRD2_k127_314726_2	485913.Krac_10794	8.02e-39	148.0	COG1217@1|root,COG1217@2|Bacteria,2G5NQ@200795|Chloroflexi	200795|Chloroflexi	T	elongation factor Tu domain 2 protein	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
SRD2_k127_3157277_0	1254432.SCE1572_36930	2.281e-99	334.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42MQJ@68525|delta/epsilon subdivisions,2WJIX@28221|Deltaproteobacteria,2YX9E@29|Myxococcales	28221|Deltaproteobacteria	P	Hemerythrin HHE cation binding domain	-	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,Hemerythrin,Hydrolase
SRD2_k127_3158451_24	180332.JTGN01000016_gene977	1.653e-18	93.0	2DP8N@1|root,3311E@2|Bacteria,1VG5U@1239|Firmicutes,24S4D@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_3158451_26	411459.RUMOBE_04123	3.712e-16	81.0	2EU6P@1|root,33MP7@2|Bacteria,1VM14@1239|Firmicutes,24U4C@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_3158451_19	370438.PTH_1450	1.487e-38	159.0	COG4753@1|root,COG4963@1|root,COG4753@2|Bacteria,COG4963@2|Bacteria,1UF2S@1239|Firmicutes,248CD@186801|Clostridia,2616F@186807|Peptococcaceae	186801|Clostridia	D	NUBPL iron-transfer P-loop NTPase	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,ParA,Response_reg
SRD2_k127_3158451_18	479434.Sthe_0904	3.032e-40	164.0	COG0438@1|root,COG0438@2|Bacteria,2G5PS@200795|Chloroflexi,27XVU@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SRD2_k127_3158451_7	326427.Cagg_2913	3.83e-79	280.0	COG0265@1|root,COG0265@2|Bacteria,2G6KV@200795|Chloroflexi,375DX@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S1 and S6, chymotrypsin Hap	-	-	1.3.1.74	ko:K08070	-	-	-	-	ko00000,ko01000	-	-	-	PDZ_2,Trypsin_2
SRD2_k127_3158451_9	867845.KI911784_gene2830	7.943e-74	255.0	COG0745@1|root,COG0745@2|Bacteria,2G6H6@200795|Chloroflexi,3752R@32061|Chloroflexia	32061|Chloroflexia	K	Two component transcriptional regulator, winged helix family	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
SRD2_k127_3158451_13	1118054.CAGW01000074_gene870	1.844e-50	195.0	COG5002@1|root,COG5002@2|Bacteria,1TS5K@1239|Firmicutes,4H9Y1@91061|Bacilli,277BU@186822|Paenibacillaceae	91061|Bacilli	T	His Kinase A (phosphoacceptor) domain	ciaH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K14982	ko02020,ko02024,map02020,map02024	M00521	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
SRD2_k127_3158451_0	1041522.MCOL_V209510	6.914e-167	543.0	COG0028@1|root,COG0028@2|Bacteria,2GM6Y@201174|Actinobacteria,232TN@1762|Mycobacteriaceae	201174|Actinobacteria	EH	Belongs to the TPP enzyme family	ilvG	GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1820	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
SRD2_k127_3158451_22	457570.Nther_1839	1.511e-23	109.0	COG5496@1|root,COG5496@2|Bacteria,1VAZJ@1239|Firmicutes,24MWR@186801|Clostridia	186801|Clostridia	S	THIoesterase	-	-	3.1.2.29	ko:K18700	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
SRD2_k127_3158451_15	525904.Tter_0257	2.822e-47	182.0	COG0110@1|root,COG0110@2|Bacteria,2NQ73@2323|unclassified Bacteria	2|Bacteria	S	Bacterial transferase hexapeptide (six repeats)	-	-	2.3.1.157,2.3.1.79,2.7.7.23	ko:K00661,ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_7,FrhB_FdhB_C,FrhB_FdhB_N,Hexapep,Hexapep_2,Mac,NTP_transferase
SRD2_k127_3158451_6	479434.Sthe_1821	6.58e-91	312.0	COG0820@1|root,COG0820@2|Bacteria,2G5SD@200795|Chloroflexi,27XRH@189775|Thermomicrobia	189775|Thermomicrobia	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
SRD2_k127_3158451_5	1121468.AUBR01000026_gene2918	1.048e-92	316.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1TP4F@1239|Firmicutes,248MM@186801|Clostridia,42F0T@68295|Thermoanaerobacterales	186801|Clostridia	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
SRD2_k127_3158451_14	1033740.CAEW01000027_gene1390	1.031e-47	188.0	COG0307@1|root,COG0307@2|Bacteria,1V1EP@1239|Firmicutes,4HC7B@91061|Bacilli,26F8V@186818|Planococcaceae	91061|Bacilli	H	Lumazine binding domain	ribE	GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS08950,iYO844.BSU23270	Lum_binding
SRD2_k127_3158451_2	635013.TherJR_1781	1.005e-158	516.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1TPH9@1239|Firmicutes,248B0@186801|Clostridia,260I8@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10830	DHBP_synthase,GTP_cyclohydro2
SRD2_k127_3158451_12	394503.Ccel_2003	1.148e-51	194.0	COG0054@1|root,COG0054@2|Bacteria,1V1DA@1239|Firmicutes,24FRS@186801|Clostridia,36HYD@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
SRD2_k127_3158451_27	1120979.ATVB01000008_gene1360	2.728e-15	78.0	COG0227@1|root,COG0227@2|Bacteria,2GQNU@201174|Actinobacteria,4D17Q@85004|Bifidobacteriales	201174|Actinobacteria	J	Ribosomal L28 family	rpmB	GO:0003674,GO:0003735,GO:0005198	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
SRD2_k127_3158451_21	748449.Halha_1204	2.286e-28	119.0	COG1302@1|root,COG1302@2|Bacteria,1V731@1239|Firmicutes,24JIA@186801|Clostridia,3WASB@53433|Halanaerobiales	186801|Clostridia	S	Asp23 family, cell envelope-related function	-	-	-	-	-	-	-	-	-	-	-	-	Asp23
SRD2_k127_3158451_3	1128421.JAGA01000002_gene200	2.997e-127	433.0	COG1461@1|root,COG1461@2|Bacteria,2NPHY@2323|unclassified Bacteria	2|Bacteria	S	Dak1_2	-	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak1_2,Dak2
SRD2_k127_3158451_11	316274.Haur_0363	6.56e-52	194.0	COG1307@1|root,COG1307@2|Bacteria,2G6PH@200795|Chloroflexi,3776W@32061|Chloroflexia	32061|Chloroflexia	S	PFAM DegV family protein	-	-	-	-	-	-	-	-	-	-	-	-	DegV
SRD2_k127_3158451_1	525904.Tter_1650	5.243e-160	541.0	COG1200@1|root,COG1200@2|Bacteria,2NNS3@2323|unclassified Bacteria	2|Bacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
SRD2_k127_3158451_20	1123023.JIAI01000006_gene244	4.868e-30	126.0	COG0742@1|root,COG0742@2|Bacteria,2GQ3G@201174|Actinobacteria,4E45R@85010|Pseudonocardiales	201174|Actinobacteria	L	Methyltransferase	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
SRD2_k127_3158451_17	251229.Chro_4395	1.331e-45	184.0	COG0669@1|root,COG0669@2|Bacteria,1G4Z8@1117|Cyanobacteria,3VJJP@52604|Pleurocapsales	1117|Cyanobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
SRD2_k127_3158451_25	370438.PTH_1752	1.616e-16	86.0	COG1193@1|root,COG1193@2|Bacteria,1UHZ5@1239|Firmicutes,25E7T@186801|Clostridia,262E1@186807|Peptococcaceae	186801|Clostridia	L	negative regulation of DNA recombination	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_3158451_28	743525.TSC_c05880	3.885e-15	76.0	COG0333@1|root,COG0333@2|Bacteria,1WKMA@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	GO:0003674,GO:0003735,GO:0005198	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
SRD2_k127_3158451_10	717605.Theco_2138	8.426e-57	209.0	COG0331@1|root,COG0331@2|Bacteria,1TPB7@1239|Firmicutes,4HBCU@91061|Bacilli,26QJX@186822|Paenibacillaceae	91061|Bacilli	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
SRD2_k127_3158451_8	1121423.JONT01000009_gene1446	9.859e-78	275.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,260VS@186807|Peptococcaceae	186801|Clostridia	IQ	PFAM short chain dehydrogenase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SRD2_k127_3158451_23	1123325.JHUV01000015_gene229	9.653e-21	102.0	COG0236@1|root,COG0236@2|Bacteria,2G491@200783|Aquificae	200783|Aquificae	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
SRD2_k127_3158451_16	1128421.JAGA01000002_gene129	3.864e-46	176.0	COG0571@1|root,COG0571@2|Bacteria,2NPCJ@2323|unclassified Bacteria	2|Bacteria	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
SRD2_k127_3158451_4	867903.ThesuDRAFT_00301	8.533e-108	387.0	COG1196@1|root,COG1196@2|Bacteria,1TPJV@1239|Firmicutes,249F4@186801|Clostridia,3WCRB@538999|Clostridiales incertae sedis	186801|Clostridia	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
SRD2_k127_3158451_31	1209984.BN978_04737	5.136e-06	53.0	COG0552@1|root,COG0552@2|Bacteria,2GJQH@201174|Actinobacteria,23680@1762|Mycobacteriaceae	201174|Actinobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
SRD2_k127_3158451_30	1335757.SPICUR_02800	8.658e-08	59.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RMUG@1236|Gammaproteobacteria,1WWWJ@135613|Chromatiales	135613|Chromatiales	O	HflC and HflK could encode or regulate a protease	-	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
SRD2_k127_3165745_0	35754.JNYJ01000029_gene9510	5.144e-73	268.0	COG4585@1|root,COG4585@2|Bacteria,2GMMU@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
SRD2_k127_3181864_9	543632.JOJL01000013_gene9501	6.514e-06	53.0	COG4447@1|root,COG4447@2|Bacteria,2I9D0@201174|Actinobacteria,4DFG8@85008|Micromonosporales	201174|Actinobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_3181864_8	211114.JOEF01000005_gene2057	4.225e-08	65.0	2F3WI@1|root,33WNQ@2|Bacteria,2IK8X@201174|Actinobacteria,4E444@85010|Pseudonocardiales	201174|Actinobacteria	S	Putative serine esterase (DUF676)	-	-	-	-	-	-	-	-	-	-	-	-	PGAP1
SRD2_k127_3181864_0	1283299.AUKG01000002_gene4674	1.088e-98	344.0	COG4585@1|root,COG4585@2|Bacteria,2GIXR@201174|Actinobacteria,4CSC0@84995|Rubrobacteria	84995|Rubrobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
SRD2_k127_3181864_2	1380390.JIAT01000010_gene4196	1.016e-60	218.0	COG2197@1|root,COG2197@2|Bacteria,2HQF1@201174|Actinobacteria,4CRZT@84995|Rubrobacteria	84995|Rubrobacteria	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
SRD2_k127_3181864_5	1048339.KB913029_gene1007	4.083e-42	156.0	COG5207@1|root,COG5207@2|Bacteria,2IKW9@201174|Actinobacteria	201174|Actinobacteria	O	Pfam Zn-finger in ubiquitin-hydrolases and other protein	-	-	-	-	-	-	-	-	-	-	-	-	zf-UBP
SRD2_k127_3181864_4	1049564.TevJSym_am00750	2.771e-45	190.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1J57W@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	Putative diguanylate phosphodiesterase	ykoW	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,dCache_3
SRD2_k127_3181864_6	292459.STH1790	1.026e-24	119.0	COG3858@1|root,COG3858@2|Bacteria,1TQK2@1239|Firmicutes,247YF@186801|Clostridia	186801|Clostridia	M	family 18	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2,Glyco_hydro_18,PG_binding_1,SLH,fn3
SRD2_k127_3181864_1	42256.RradSPS_3003	5.653e-67	254.0	COG0500@1|root,COG2226@2|Bacteria,2HEKM@201174|Actinobacteria,4CQ49@84995|Rubrobacteria	84995|Rubrobacteria	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
SRD2_k127_3181864_7	446462.Amir_3423	5.667e-19	91.0	COG0640@1|root,COG0640@2|Bacteria,2IQDH@201174|Actinobacteria,4E4AY@85010|Pseudonocardiales	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
SRD2_k127_3181864_3	1382356.JQMP01000003_gene1803	2.343e-55	200.0	COG1131@1|root,COG1131@2|Bacteria,2G69S@200795|Chloroflexi,27XTG@189775|Thermomicrobia	189775|Thermomicrobia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SRD2_k127_3188912_1	572477.Alvin_1055	4.062e-30	130.0	COG1403@1|root,COG1403@2|Bacteria,1QE4E@1224|Proteobacteria,1RS5S@1236|Gammaproteobacteria,1WZVU@135613|Chromatiales	135613|Chromatiales	L	SMART HNH nuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5,RRXRR
SRD2_k127_3188912_0	1123242.JH636435_gene1450	3.718e-95	323.0	COG3011@1|root,COG3011@2|Bacteria,2IYVQ@203682|Planctomycetes	203682|Planctomycetes	S	Vitamin K-dependent gamma-carboxylase	-	-	-	-	-	-	-	-	-	-	-	-	DUF393,VKG_Carbox
SRD2_k127_3202770_1	345341.KUTG_00490	7.177e-40	161.0	COG5607@1|root,COG5607@2|Bacteria,2GJZH@201174|Actinobacteria,4EAUR@85010|Pseudonocardiales	201174|Actinobacteria	S	CYTH	-	-	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH
SRD2_k127_3202770_0	164757.Mjls_1905	1.329e-156	507.0	COG0855@1|root,COG0855@2|Bacteria,2GJ0B@201174|Actinobacteria,2360S@1762|Mycobacteriaceae	201174|Actinobacteria	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	GO:0000287,GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0008976,GO:0009267,GO:0009405,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0015968,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019538,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0036293,GO:0040007,GO:0042594,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0070482,GO:0071496,GO:0071704,GO:0071944,GO:1901564	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
SRD2_k127_3216863_18	1120949.KB903326_gene3139	5.091e-58	204.0	COG0346@1|root,COG0346@2|Bacteria,2IG0S@201174|Actinobacteria,4DED6@85008|Micromonosporales	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SRD2_k127_3216863_20	208444.JNYY01000009_gene3469	2.19e-57	213.0	COG0122@1|root,COG0122@2|Bacteria,2IB0Q@201174|Actinobacteria,4E49F@85010|Pseudonocardiales	201174|Actinobacteria	L	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
SRD2_k127_3216863_21	525904.Tter_1368	1.294e-54	199.0	COG0461@1|root,COG0461@2|Bacteria,2NPFJ@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
SRD2_k127_3216863_14	255470.cbdbA1324	3.211e-89	317.0	COG0167@1|root,COG0167@2|Bacteria,2G6RH@200795|Chloroflexi,34CMM@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
SRD2_k127_3216863_24	644282.Deba_2876	1.675e-46	179.0	COG0543@1|root,COG0543@2|Bacteria,1RF43@1224|Proteobacteria,42RQK@68525|delta/epsilon subdivisions,2WNJU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
SRD2_k127_3216863_0	1382356.JQMP01000003_gene2075	0.0	1294.0	COG0458@1|root,COG0458@2|Bacteria,2G5NX@200795|Chloroflexi,27XRT@189775|Thermomicrobia	189775|Thermomicrobia	F	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
SRD2_k127_3216863_31	1163409.UUA_09246	1.792e-09	71.0	2EHAS@1|root,33B2M@2|Bacteria,1NZNX@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_3216863_32	1163409.UUA_09246	9.145e-09	66.0	2EHAS@1|root,33B2M@2|Bacteria,1NZNX@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_3216863_15	309801.trd_0214	1.283e-83	293.0	COG0044@1|root,COG0044@2|Bacteria,2G640@200795|Chloroflexi,27XK1@189775|Thermomicrobia	189775|Thermomicrobia	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
SRD2_k127_3216863_23	1306174.JODP01000013_gene7506	7.128e-49	185.0	COG2065@1|root,COG2065@2|Bacteria,2GJNP@201174|Actinobacteria	201174|Actinobacteria	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
SRD2_k127_3216863_9	15368.BRADI3G18990.1	1.585e-111	381.0	COG0458@1|root,KOG0370@2759|Eukaryota,37MJ1@33090|Viridiplantae,3GGQ1@35493|Streptophyta,3KQ6H@4447|Liliopsida,3I5GI@38820|Poales	35493|Streptophyta	EF	Belongs to the ATCase OTCase family	PYRB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009267,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009605,GO:0009987,GO:0009991,GO:0016036,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034641,GO:0034654,GO:0042594,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
SRD2_k127_3216863_27	937777.Deipe_0421	1.806e-29	127.0	COG0639@1|root,COG0639@2|Bacteria,1WK9U@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
SRD2_k127_3216863_19	1229203.KI301992_gene73	1.267e-57	210.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	catD	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,SnoaL_2
SRD2_k127_3216863_30	477974.Daud_1360	7.75e-14	76.0	2DNS1@1|root,32YVX@2|Bacteria,1VEGC@1239|Firmicutes,24SFG@186801|Clostridia,2636S@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF2905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2905
SRD2_k127_3216863_10	765420.OSCT_2657	1.958e-110	380.0	COG0608@1|root,COG0608@2|Bacteria,2G5US@200795|Chloroflexi,374UZ@32061|Chloroflexia	32061|Chloroflexia	L	PFAM phosphoesterase, RecJ domain protein	-	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
SRD2_k127_3216863_22	316058.RPB_4699	5.437e-51	194.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2TSX8@28211|Alphaproteobacteria,3JUVR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Iron-containing alcohol dehydrogenase	MA20_22910	-	1.3.1.32	ko:K00217	ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220	-	R02988,R02989,R05355,R06848,R07781,R09137,R09138,R09223,R09224	RC00107,RC01335,RC01689,RC02442	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
SRD2_k127_3216863_5	1111479.AXAR01000001_gene330	4.1e-145	469.0	COG3185@1|root,COG3185@2|Bacteria,1UZP2@1239|Firmicutes,4HDQI@91061|Bacilli,2791W@186823|Alicyclobacillaceae	91061|Bacilli	E	Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal	hppD	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase,Glyoxalase_5
SRD2_k127_3216863_7	330214.NIDE3110	1.325e-129	424.0	COG3508@1|root,COG3508@2|Bacteria	2|Bacteria	Q	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate	hmgA	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
SRD2_k127_3216863_8	1500897.JQNA01000002_gene4645	3.325e-123	434.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1K0RA@119060|Burkholderiaceae	28216|Betaproteobacteria	T	GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GAF_2,GGDEF,HAMP,PAS,PAS_4,PAS_8,PAS_9,dCache_3
SRD2_k127_3216863_4	469383.Cwoe_4165	2.049e-153	508.0	COG1060@1|root,COG1060@2|Bacteria,2GK83@201174|Actinobacteria,4CPHP@84995|Rubrobacteria	84995|Rubrobacteria	H	Elongator protein 3 MiaB NifB	-	-	2.5.1.77	ko:K11779	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
SRD2_k127_3216863_11	1206743.BAGM01000056_gene5292	1.333e-106	367.0	COG3511@1|root,COG3511@2|Bacteria,2GKPN@201174|Actinobacteria,4FV9U@85025|Nocardiaceae	201174|Actinobacteria	M	COG3511 Phospholipase C	plc	GO:0003674,GO:0003824,GO:0004620,GO:0004629,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006629,GO:0008081,GO:0008150,GO:0008152,GO:0009056,GO:0009405,GO:0016020,GO:0016042,GO:0016298,GO:0016787,GO:0016788,GO:0034480,GO:0035821,GO:0042578,GO:0044003,GO:0044238,GO:0044403,GO:0044419,GO:0044464,GO:0051701,GO:0051704,GO:0051817,GO:0052008,GO:0052043,GO:0052111,GO:0052185,GO:0052188,GO:0052368,GO:0071704,GO:0071944,GO:1901575	3.1.4.3	ko:K01114	ko00562,ko00564,ko00565,ko01100,ko01110,ko02024,ko04919,map00562,map00564,map00565,map01100,map01110,map02024,map04919	-	R01312,R02027,R02052,R03332,R07381	RC00017,RC00425	ko00000,ko00001,ko01000,ko02042	-	-	iNJ661.Rv1755c	Phosphoesterase
SRD2_k127_3216863_25	1174528.JH992898_gene3857	1.572e-35	145.0	COG0412@1|root,COG0412@2|Bacteria,1FZX6@1117|Cyanobacteria	1117|Cyanobacteria	Q	PFAM Dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
SRD2_k127_3216863_16	383372.Rcas_4411	5.813e-83	293.0	COG0415@1|root,COG0415@2|Bacteria,2G5WD@200795|Chloroflexi,375BT@32061|Chloroflexia	32061|Chloroflexia	L	PFAM DNA photolyase, FAD-binding	-	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
SRD2_k127_3216863_3	235909.GK0267	2.921e-165	540.0	COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,4H9YY@91061|Bacilli,1WEF4@129337|Geobacillus	91061|Bacilli	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
SRD2_k127_3216863_26	1121468.AUBR01000017_gene2356	4.289e-35	153.0	COG0299@1|root,COG0299@2|Bacteria,1V3RJ@1239|Firmicutes,249JC@186801|Clostridia,42GE6@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS04225	Formyl_trans_N
SRD2_k127_3216863_12	472759.Nhal_0873	2.019e-99	334.0	COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,1RNZZ@1236|Gammaproteobacteria,1WWGF@135613|Chromatiales	135613|Chromatiales	F	PFAM AIR synthase related protein	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
SRD2_k127_3216863_6	1386089.N865_16800	2.91e-142	467.0	COG0438@1|root,COG0438@2|Bacteria,2ICGI@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1,YHS
SRD2_k127_3216863_17	398527.Bphyt_2886	1.277e-62	227.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2VQ62@28216|Betaproteobacteria,1K2D4@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GGDEF
SRD2_k127_3216863_1	1120936.KB907215_gene3950	1.716e-181	619.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,Big_2,CBM_25,Calx-beta,DUF4114,P_proprotein,Peptidase_S8,SBBP,SLH,VCBS
SRD2_k127_3216863_29	1173028.ANKO01000132_gene1911	4.552e-19	97.0	COG4719@1|root,COG4719@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,FTP,Peptidase_M36,SdrD_B
SRD2_k127_3216863_28	649831.L083_5798	2.46e-21	99.0	COG2867@1|root,COG2867@2|Bacteria,2IIFW@201174|Actinobacteria	201174|Actinobacteria	I	negative regulation of translational initiation	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
SRD2_k127_3216863_2	316274.Haur_4571	3.304e-168	544.0	COG0034@1|root,COG0034@2|Bacteria,2G61T@200795|Chloroflexi,374UB@32061|Chloroflexia	32061|Chloroflexia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
SRD2_k127_3216863_13	1118054.CAGW01000058_gene2063	9.119e-96	322.0	COG0046@1|root,COG0046@2|Bacteria,1TPAS@1239|Firmicutes,4HB3N@91061|Bacilli,26RX8@186822|Paenibacillaceae	91061|Bacilli	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
SRD2_k127_3254643_2	1158050.KB895455_gene1714	8.944e-66	234.0	COG1071@1|root,COG1071@2|Bacteria,2IBRC@201174|Actinobacteria	201174|Actinobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
SRD2_k127_3254643_0	1151119.KB895489_gene650	5.06e-270	841.0	COG0365@1|root,COG0365@2|Bacteria,2GNE8@201174|Actinobacteria	201174|Actinobacteria	I	synthetase	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
SRD2_k127_3254643_3	469383.Cwoe_3445	5.208e-42	172.0	COG1503@1|root,COG1503@2|Bacteria,2I8DT@201174|Actinobacteria	201174|Actinobacteria	J	translation release factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_3254643_1	1429046.RR21198_1177	1.768e-111	373.0	COG1752@1|root,COG1752@2|Bacteria,2HJ6N@201174|Actinobacteria,4G5HY@85025|Nocardiaceae	201174|Actinobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
SRD2_k127_3254643_4	485913.Krac_1964	5.215e-30	124.0	COG3945@1|root,COG3945@2|Bacteria,2G96X@200795|Chloroflexi	200795|Chloroflexi	S	TIGRFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
SRD2_k127_3254643_5	1283283.ATXA01000015_gene85	3.951e-06	57.0	COG1403@1|root,COG1403@2|Bacteria,2HAHI@201174|Actinobacteria,4ESDB@85013|Frankiales	201174|Actinobacteria	L	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
SRD2_k127_3255154_2	321961.AVAO01000003_gene106	1.677e-26	110.0	COG0504@1|root,COG0504@2|Bacteria,3WSXC@544448|Tenericutes	544448|Tenericutes	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
SRD2_k127_3255154_3	1268622.AVS7_01085	3.082e-18	98.0	COG3055@1|root,COG4447@1|root,COG5279@1|root,COG3055@2|Bacteria,COG4447@2|Bacteria,COG5279@2|Bacteria,1R0N3@1224|Proteobacteria	1224|Proteobacteria	D	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_3255154_1	929712.KI912613_gene2340	2.316e-27	115.0	COG0526@1|root,COG0526@2|Bacteria,2HZTZ@201174|Actinobacteria	201174|Actinobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
SRD2_k127_3255154_0	710111.FraQA3DRAFT_6069	2.133e-29	119.0	COG0526@1|root,COG0526@2|Bacteria,2HZTZ@201174|Actinobacteria	201174|Actinobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
SRD2_k127_3260565_2	469383.Cwoe_5392	3.852e-35	147.0	COG4447@1|root,COG4447@2|Bacteria,2IT8P@201174|Actinobacteria	201174|Actinobacteria	M	phospholipase C	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_3260565_1	526227.Mesil_2849	2.46e-44	176.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,1WM3F@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_3,PAS_4,PAS_8
SRD2_k127_3260565_0	1521187.JPIM01000021_gene146	7.053e-46	177.0	COG2197@1|root,COG2197@2|Bacteria,2G6T1@200795|Chloroflexi,376HK@32061|Chloroflexia	32061|Chloroflexia	K	Two component transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
SRD2_k127_33224_8	479434.Sthe_1935	1.221e-108	364.0	COG1071@1|root,COG1071@2|Bacteria,2G5SF@200795|Chloroflexi,27XY9@189775|Thermomicrobia	189775|Thermomicrobia	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
SRD2_k127_33224_1	309801.trd_A0505	1.226e-178	591.0	COG1239@1|root,COG1239@2|Bacteria,2GB7G@200795|Chloroflexi,27XRK@189775|Thermomicrobia	189775|Thermomicrobia	H	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX	-	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	-
SRD2_k127_33224_3	479434.Sthe_3486	1.085e-165	544.0	COG4867@1|root,COG4867@2|Bacteria,2G8A6@200795|Chloroflexi,27XPF@189775|Thermomicrobia	189775|Thermomicrobia	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_33224_13	864702.OsccyDRAFT_4122	2.874e-36	147.0	COG0545@1|root,COG0545@2|Bacteria,1G5T1@1117|Cyanobacteria,1HAQ3@1150|Oscillatoriales	1117|Cyanobacteria	O	PFAM FKBP-type peptidyl-prolyl cis-trans isomerase	fkpA	-	5.2.1.8	ko:K01802,ko:K03772	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
SRD2_k127_33224_17	350054.Mflv_1021	2.345e-07	62.0	COG3427@1|root,COG3427@2|Bacteria,2IITI@201174|Actinobacteria,239J3@1762|Mycobacteriaceae	201174|Actinobacteria	S	cyclase dehydrase	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
SRD2_k127_33224_10	1380386.JIAW01000005_gene1708	2.308e-78	277.0	COG0204@1|root,COG0204@2|Bacteria,2GNBB@201174|Actinobacteria,2363I@1762|Mycobacteriaceae	201174|Actinobacteria	I	Acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
SRD2_k127_33224_15	1158612.I580_00206	2.339e-23	115.0	COG3797@1|root,COG3797@2|Bacteria,1V426@1239|Firmicutes,4HI2S@91061|Bacilli,4B29E@81852|Enterococcaceae	91061|Bacilli	S	Protein of unknown function (DUF1697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
SRD2_k127_33224_14	1278308.KB907078_gene1931	2.294e-35	152.0	COG0683@1|root,COG0683@2|Bacteria,2IEFV@201174|Actinobacteria,4FQKX@85023|Microbacteriaceae	201174|Actinobacteria	E	Periplasmic binding protein domain	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
SRD2_k127_33224_18	938289.CAJN020000001_gene1273	1.142e-06	61.0	COG4395@1|root,COG4395@2|Bacteria,1V2HK@1239|Firmicutes,24GHI@186801|Clostridia	186801|Clostridia	S	Tim44	-	-	-	-	-	-	-	-	-	-	-	-	Tim44,zinc_ribbon_2
SRD2_k127_33224_6	1056816.JAFQ01000004_gene5755	9.377e-115	393.0	COG1793@1|root,COG1793@2|Bacteria,2I2EA@201174|Actinobacteria,4FXJN@85025|Nocardiaceae	201174|Actinobacteria	L	DNA ligase	ligC	-	-	-	-	-	-	-	-	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
SRD2_k127_33224_5	469383.Cwoe_3833	1.061e-135	445.0	COG3285@1|root,COG3285@2|Bacteria,2GM0A@201174|Actinobacteria,4CS2X@84995|Rubrobacteria	84995|Rubrobacteria	L	DNA primase, small subunit	-	-	-	-	-	-	-	-	-	-	-	-	DNA_primase_S
SRD2_k127_33224_2	926560.KE387027_gene419	1.453e-172	557.0	COG0477@1|root,COG0477@2|Bacteria,1WMC1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SRD2_k127_33224_12	1449069.JMLO01000005_gene1379	1.264e-36	150.0	COG0300@1|root,COG0300@2|Bacteria,2I64P@201174|Actinobacteria,4FYJZ@85025|Nocardiaceae	201174|Actinobacteria	S	KR domain	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
SRD2_k127_33224_11	44251.PDUR_12965	1.328e-60	216.0	COG0120@1|root,COG0120@2|Bacteria,1V1DB@1239|Firmicutes,4HFQ7@91061|Bacilli,26QCU@186822|Paenibacillaceae	91061|Bacilli	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
SRD2_k127_33224_0	66373.JOFQ01000015_gene2345	1.408e-257	808.0	COG0021@1|root,COG0021@2|Bacteria,2I36F@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the transketolase family	tkt3	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
SRD2_k127_33224_7	1382306.JNIM01000001_gene765	7.675e-114	378.0	COG0176@1|root,COG0176@2|Bacteria,2GA93@200795|Chloroflexi	200795|Chloroflexi	H	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
SRD2_k127_33224_4	479434.Sthe_2434	2.154e-151	501.0	COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,2G67J@200795|Chloroflexi,27XXA@189775|Thermomicrobia	189775|Thermomicrobia	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2,5.3.1.9	ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	PGI,TAL_FSA
SRD2_k127_33224_9	330214.NIDE2204	7.803e-84	284.0	COG1023@1|root,COG1023@2|Bacteria	2|Bacteria	G	D-gluconate metabolic process	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
SRD2_k127_3334947_4	1416759.AYMR01000014_gene4175	0.0004082	44.0	COG3070@1|root,COG3070@2|Bacteria,2IRAD@201174|Actinobacteria	201174|Actinobacteria	K	TfoX N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	TfoX_N
SRD2_k127_3334947_1	2074.JNYD01000003_gene3462	5.289e-107	377.0	COG1073@1|root,COG1073@2|Bacteria,2IASV@201174|Actinobacteria,4E960@85010|Pseudonocardiales	201174|Actinobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	Esterase,Peptidase_S9
SRD2_k127_3334947_2	1242864.D187_004908	1.012e-36	146.0	COG1309@1|root,COG1309@2|Bacteria,1PG5X@1224|Proteobacteria,434A4@68525|delta/epsilon subdivisions,2X2DZ@28221|Deltaproteobacteria,2Z2MC@29|Myxococcales	28221|Deltaproteobacteria	K	WHG domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
SRD2_k127_3334947_0	118163.Ple7327_0865	1.721e-151	496.0	COG1233@1|root,COG1233@2|Bacteria,1G4AK@1117|Cyanobacteria	1117|Cyanobacteria	Q	NAD(P)-binding Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
SRD2_k127_3334947_3	1236976.JCM16418_2855	7.758e-26	113.0	COG1470@1|root,COG1470@2|Bacteria,1TRGE@1239|Firmicutes,4HBPI@91061|Bacilli,26STU@186822|Paenibacillaceae	91061|Bacilli	S	Protein of unknown function (DUF3048) C-terminal domain	yerB	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
SRD2_k127_3352666_0	316067.Geob_2932	1.759e-47	179.0	COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,42MK9@68525|delta/epsilon subdivisions,2WJ1C@28221|Deltaproteobacteria,43UHM@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	SMART Nucleotide binding protein, PINc	phoH1	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
SRD2_k127_3352666_1	1140.Synpcc7942_1457	5.571e-34	140.0	COG0204@1|root,COG0204@2|Bacteria,1G173@1117|Cyanobacteria,1GZCH@1129|Synechococcus	1117|Cyanobacteria	I	1-acyl-sn-glycerol-3-phosphate acyltransferase	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
SRD2_k127_3352666_2	1208583.COMX_05110	2.438e-19	90.0	COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,2U71H@28211|Alphaproteobacteria,2JSDW@204441|Rhodospirillales	204441|Rhodospirillales	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
SRD2_k127_3352876_1	1041930.Mtc_0244	1.071e-75	260.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUK9@28890|Euryarchaeota,2N95K@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SRD2_k127_3352876_2	479434.Sthe_3364	2.25e-68	254.0	COG0842@1|root,COG0842@2|Bacteria,2G6PG@200795|Chloroflexi,27Z1H@189775|Thermomicrobia	189775|Thermomicrobia	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
SRD2_k127_3352876_3	66875.JODY01000006_gene2133	1.093e-36	143.0	COG0454@1|root,COG0456@2|Bacteria,2IHRD@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	ypeA	-	2.3.1.1	ko:K22477	ko00220,ko01210,ko01230,map00220,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
SRD2_k127_3352876_0	479432.Sros_9017	1.76e-321	994.0	COG3387@1|root,COG3387@2|Bacteria,2GJAD@201174|Actinobacteria,4EGNI@85012|Streptosporangiales	201174|Actinobacteria	G	Glycosyl hydrolases family 15	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
SRD2_k127_3352876_4	68570.DC74_1424	2.278e-32	135.0	COG0491@1|root,COG0491@2|Bacteria,2IB2K@201174|Actinobacteria	201174|Actinobacteria	S	beta-lactamase domain protein	-	-	3.1.1.81	ko:K13075	ko02024,map02024	-	R08970	RC00713	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
SRD2_k127_3352876_5	1283299.AUKG01000002_gene4305	1.919e-25	111.0	COG3631@1|root,COG3631@2|Bacteria,2ISHN@201174|Actinobacteria,4CSWH@84995|Rubrobacteria	84995|Rubrobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
SRD2_k127_3392753_1	1192034.CAP_1668	4.797e-46	171.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,42NCX@68525|delta/epsilon subdivisions,2WIYY@28221|Deltaproteobacteria,2YWP3@29|Myxococcales	28221|Deltaproteobacteria	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
SRD2_k127_3392753_0	1121934.AUDX01000004_gene2663	6.218e-65	238.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4FK8K@85023|Microbacteriaceae	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SRD2_k127_340015_0	1395587.P364_0124120	1.456e-60	222.0	COG1028@1|root,COG1028@2|Bacteria,1U2GS@1239|Firmicutes,4H9R9@91061|Bacilli,26QGX@186822|Paenibacillaceae	91061|Bacilli	IQ	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	fabG1	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SRD2_k127_3500740_2	485913.Krac_2203	5.342e-19	90.0	COG3677@1|root,COG3677@2|Bacteria,2G6SJ@200795|Chloroflexi	200795|Chloroflexi	L	PFAM Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_3500740_0	991905.SL003B_4075	9.072e-109	367.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria	1224|Proteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_38,HTH_7,rve
SRD2_k127_3500740_1	1123229.AUBC01000040_gene3836	1.707e-86	300.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TS16@28211|Alphaproteobacteria,3JSGF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
SRD2_k127_3500740_3	876269.ARWA01000001_gene2541	0.0001209	45.0	COG3439@1|root,COG3439@2|Bacteria,1RJ87@1224|Proteobacteria,2UBJ4@28211|Alphaproteobacteria,3NBW5@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
SRD2_k127_357185_3	35754.JNYJ01000035_gene3919	3.296e-79	276.0	COG2159@1|root,COG2159@2|Bacteria,2GMQY@201174|Actinobacteria,4D9GY@85008|Micromonosporales	201174|Actinobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
SRD2_k127_357185_1	378806.STAUR_0663	3.858e-154	518.0	COG1470@1|root,COG3537@1|root,COG1470@2|Bacteria,COG3537@2|Bacteria,1MXCY@1224|Proteobacteria,43BAT@68525|delta/epsilon subdivisions,2X6PZ@28221|Deltaproteobacteria,2YX4I@29|Myxococcales	28221|Deltaproteobacteria	G	Glycosyl hydrolase family 92	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_92
SRD2_k127_357185_5	1304872.JAGC01000003_gene2861	6.708e-47	174.0	COG1607@1|root,COG1607@2|Bacteria,1RAEQ@1224|Proteobacteria,42SPA@68525|delta/epsilon subdivisions,2WPPE@28221|Deltaproteobacteria,2MAJU@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
SRD2_k127_357185_10	886293.Sinac_3474	4.21e-13	78.0	COG3305@1|root,COG3305@2|Bacteria	2|Bacteria	S	Predicted membrane protein (DUF2127)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2127
SRD2_k127_357185_6	1382306.JNIM01000001_gene4120	1.342e-38	157.0	COG0558@1|root,COG0558@2|Bacteria,2G6RT@200795|Chloroflexi	200795|Chloroflexi	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
SRD2_k127_357185_2	479434.Sthe_0282	9.239e-97	337.0	COG0438@1|root,COG0438@2|Bacteria,2G61C@200795|Chloroflexi,27XU5@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyl transferase 4-like domain	-	-	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
SRD2_k127_357185_4	485913.Krac_8940	2.359e-49	186.0	COG0613@1|root,COG0613@2|Bacteria,2G74N@200795|Chloroflexi	200795|Chloroflexi	S	SMART phosphoesterase PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP,PHP_C
SRD2_k127_357185_7	882082.SaccyDRAFT_1858	4.681e-34	149.0	COG1560@1|root,COG1560@2|Bacteria,2GM7B@201174|Actinobacteria,4E0NM@85010|Pseudonocardiales	201174|Actinobacteria	M	lipid A biosynthesis acyltransferase	htrB	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.3.1.265	ko:K22311	-	-	-	-	ko00000,ko01000	-	-	-	Lip_A_acyltrans
SRD2_k127_357185_9	1382306.JNIM01000001_gene4124	5.594e-31	136.0	COG1560@1|root,COG1560@2|Bacteria	2|Bacteria	M	Kdo2-lipid A biosynthetic process	-	-	2.3.1.241,2.3.1.265	ko:K02517,ko:K22311	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
SRD2_k127_357185_0	255470.cbdbA943	6.853e-176	561.0	COG1260@1|root,COG1260@2|Bacteria,2G5YH@200795|Chloroflexi,34CJX@301297|Dehalococcoidia	301297|Dehalococcoidia	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
SRD2_k127_357185_8	552811.Dehly_0528	3.057e-31	134.0	COG0558@1|root,COG0558@2|Bacteria,2G6ZT@200795|Chloroflexi,34D5W@301297|Dehalococcoidia	301297|Dehalococcoidia	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
SRD2_k127_357185_11	89187.ISM_09786	1.875e-08	61.0	COG0640@1|root,COG0640@2|Bacteria,1N10H@1224|Proteobacteria,2UBRH@28211|Alphaproteobacteria,46R6P@74030|Roseovarius	28211|Alphaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
SRD2_k127_357185_12	1206733.BAGC01000026_gene4884	5.7e-07	53.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4FU83@85025|Nocardiaceae	201174|Actinobacteria	EGP	the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
SRD2_k127_3578575_0	1120949.KB903294_gene4578	7.512e-09	61.0	COG2197@1|root,COG2197@2|Bacteria,2GJKM@201174|Actinobacteria,4DAJT@85008|Micromonosporales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	yhcZ	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
SRD2_k127_3583664_2	710696.Intca_0191	3.613e-110	372.0	COG1249@1|root,COG1249@2|Bacteria,2GJJK@201174|Actinobacteria,4FFH2@85021|Intrasporangiaceae	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
SRD2_k127_3583664_5	1380354.JIAN01000006_gene1024	2.642e-44	182.0	COG2206@1|root,COG2206@2|Bacteria,2GJS8@201174|Actinobacteria	201174|Actinobacteria	T	metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
SRD2_k127_3583664_1	373903.Hore_12400	1.156e-144	470.0	COG0568@1|root,COG0568@2|Bacteria,1TPD6@1239|Firmicutes,2481I@186801|Clostridia,3WABM@53433|Halanaerobiales	186801|Clostridia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
SRD2_k127_3583664_3	309801.trd_0421	1.092e-90	321.0	COG0358@1|root,COG0358@2|Bacteria,2G65X@200795|Chloroflexi,27XKY@189775|Thermomicrobia	189775|Thermomicrobia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_4,Toprim_N,zf-CHC2
SRD2_k127_3583664_6	1306406.ASHX01000002_gene4826	8.587e-26	123.0	COG2936@1|root,COG2936@2|Bacteria,2I1ZG@201174|Actinobacteria	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	PepX_C,Peptidase_S15
SRD2_k127_3583664_0	760568.Desku_2615	0.0	1021.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,247RW@186801|Clostridia,260B9@186807|Peptococcaceae	186801|Clostridia	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
SRD2_k127_3583664_4	2002.JOEQ01000024_gene45	2.69e-47	179.0	COG5658@1|root,COG5658@2|Bacteria,2ID8C@201174|Actinobacteria	201174|Actinobacteria	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF1648,SdpI
SRD2_k127_3583664_7	298655.KI912266_gene5307	1.316e-21	95.0	COG0423@1|root,COG0423@2|Bacteria,2GIT3@201174|Actinobacteria,4ES4G@85013|Frankiales	201174|Actinobacteria	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
SRD2_k127_359069_2	1266908.AQPB01000033_gene1663	2.401e-42	166.0	COG3280@1|root,COG3280@2|Bacteria	2|Bacteria	G	synthase	treY	GO:0000272,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0030978,GO:0030980,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0047470,GO:0071704,GO:1901575,GO:1901576	2.4.1.25,5.4.99.15	ko:K00705,ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R05196,R09995	RC00049	ko00000,ko00001,ko00002,ko01000	-	GH13,GH77	-	Alpha-amylase,Glyco_hydro_77
SRD2_k127_359069_0	105559.Nwat_1376	2.733e-308	959.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,1WX62@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
SRD2_k127_359069_1	1267535.KB906767_gene4703	3.566e-117	391.0	COG1640@1|root,COG1640@2|Bacteria	2|Bacteria	G	4-alpha-glucanotransferase	malQ	-	2.4.1.18,2.4.1.25,3.2.1.196,5.4.99.15	ko:K00700,ko:K00705,ko:K02438,ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R02110,R02111,R05196,R09995	RC00049	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13,GH77	iJN678.malQ	Alpha-amylase,Glyco_hydro_77
SRD2_k127_3612714_3	455632.SGR_5593	2.988e-42	158.0	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria,418VN@629295|Streptomyces griseus group	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	drrA_2	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SRD2_k127_3612714_2	1463936.JOJI01000034_gene2549	9.035e-97	329.0	COG0842@1|root,COG0842@2|Bacteria,2GN6S@201174|Actinobacteria	201174|Actinobacteria	V	transport, permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
SRD2_k127_3612714_1	28444.JODQ01000001_gene2485	3.491e-106	349.0	COG4221@1|root,COG4221@2|Bacteria,2GP05@201174|Actinobacteria,4EK8D@85012|Streptosporangiales	201174|Actinobacteria	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SRD2_k127_3612714_0	1068980.ARVW01000001_gene7666	8.44e-146	473.0	COG2141@1|root,COG2141@2|Bacteria,2GIY3@201174|Actinobacteria,4DXE3@85010|Pseudonocardiales	201174|Actinobacteria	C	PFAM Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
SRD2_k127_38111_1	309801.trd_1599	1.528e-23	107.0	COG5002@1|root,COG5002@2|Bacteria,2G67W@200795|Chloroflexi,27XFQ@189775|Thermomicrobia	189775|Thermomicrobia	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS
SRD2_k127_38111_0	456442.Mboo_0434	5.217e-87	299.0	COG0515@1|root,arCOG03682@2157|Archaea,2XWZP@28890|Euryarchaeota	28890|Euryarchaeota	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	NosD,Pkinase
SRD2_k127_3830125_2	196162.Noca_1531	3.686e-06	51.0	COG0477@1|root,COG0477@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	mdtH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06610,ko:K08162	-	-	-	-	ko00000,ko02000	2.A.1.1.27,2.A.1.2.21	-	-	MFS_1,Sugar_tr
SRD2_k127_3830125_1	653045.Strvi_3963	3.169e-25	116.0	COG2267@1|root,COG2267@2|Bacteria,2IGKW@201174|Actinobacteria	201174|Actinobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
SRD2_k127_3830125_0	485913.Krac_9215	1.457e-26	124.0	COG1376@1|root,COG1376@2|Bacteria,2G6ZY@200795|Chloroflexi	200795|Chloroflexi	M	PFAM ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	LysM,YkuD
SRD2_k127_386933_19	1293048.CBMB010000006_gene3020	9.775e-36	158.0	COG0639@1|root,arCOG00792@2157|Archaea,2Y84R@28890|Euryarchaeota	28890|Euryarchaeota	L	DNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12
SRD2_k127_386933_18	1280706.AUJE01000039_gene2925	8.686e-37	141.0	COG1278@1|root,COG1278@2|Bacteria,1VBBH@1239|Firmicutes,4H4QP@909932|Negativicutes	909932|Negativicutes	K	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
SRD2_k127_386933_10	1283299.AUKG01000001_gene2765	3.687e-70	246.0	COG1024@1|root,COG1024@2|Bacteria,2GJ0N@201174|Actinobacteria,4CPTH@84995|Rubrobacteria	84995|Rubrobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
SRD2_k127_386933_9	1120972.AUMH01000007_gene1660	1.154e-74	264.0	COG0119@1|root,COG1024@1|root,COG0119@2|Bacteria,COG1024@2|Bacteria,1TQG3@1239|Firmicutes,4HA1U@91061|Bacilli,2795U@186823|Alicyclobacillaceae	91061|Bacilli	E	HMGL-like	-	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
SRD2_k127_386933_0	471223.GWCH70_1836	2.411e-221	698.0	COG4799@1|root,COG4799@2|Bacteria,1TQCV@1239|Firmicutes,4HBK9@91061|Bacilli,1WEPJ@129337|Geobacillus	91061|Bacilli	I	Carboxyl transferase domain	yngE	-	-	-	-	-	-	-	-	-	-	iYO844.BSU18210	Carboxyl_trans
SRD2_k127_386933_12	313589.JNB_14478	6.624e-62	227.0	2AKGE@1|root,30DHP@2|Bacteria,2I885@201174|Actinobacteria,4FH35@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_386933_4	469383.Cwoe_4746	2.003e-119	392.0	COG0346@1|root,COG0346@2|Bacteria,2IAYN@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K15975	-	-	-	-	ko00000	-	-	-	Glyoxalase
SRD2_k127_386933_26	215803.DB30_0234	9.922e-15	86.0	COG1846@1|root,COG1846@2|Bacteria,1N6YD@1224|Proteobacteria,433TH@68525|delta/epsilon subdivisions,2X3E9@28221|Deltaproteobacteria,2YVPE@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
SRD2_k127_386933_31	1094980.Mpsy_0691	0.0001254	50.0	COG1983@1|root,arCOG03456@2157|Archaea,2XZT2@28890|Euryarchaeota,2NBEK@224756|Methanomicrobia	224756|Methanomicrobia	K	PspC domain	-	-	-	-	-	-	-	-	-	-	-	-	PspC
SRD2_k127_386933_8	1122939.ATUD01000012_gene3233	1.322e-78	284.0	COG0578@1|root,COG0578@2|Bacteria,2GJKN@201174|Actinobacteria,4CPYZ@84995|Rubrobacteria	84995|Rubrobacteria	C	C-terminal domain of alpha-glycerophosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	DAO,DAO_C
SRD2_k127_386933_7	1117108.PAALTS15_01020	3.891e-79	274.0	COG0179@1|root,COG0179@2|Bacteria,1UY98@1239|Firmicutes,4HC89@91061|Bacilli,26UR6@186822|Paenibacillaceae	91061|Bacilli	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	3.7.1.2	ko:K16171	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
SRD2_k127_386933_3	309801.trd_1170	1.71e-122	412.0	COG0477@1|root,COG2814@2|Bacteria,2GA6K@200795|Chloroflexi,27XGR@189775|Thermomicrobia	189775|Thermomicrobia	P	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
SRD2_k127_386933_28	287986.DV20_27330	9.503e-14	79.0	COG1846@1|root,COG1846@2|Bacteria,2IIAG@201174|Actinobacteria,4EBK0@85010|Pseudonocardiales	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
SRD2_k127_386933_25	1037409.BJ6T_27480	6.124e-16	79.0	COG5552@1|root,COG5552@2|Bacteria,1MZBV@1224|Proteobacteria,2UC5C@28211|Alphaproteobacteria,3JZF4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Uncharacterized conserved protein (DUF2277)	MA20_01405	-	-	-	-	-	-	-	-	-	-	-	DUF2277
SRD2_k127_386933_22	383372.Rcas_0861	2.28e-28	126.0	COG0526@1|root,COG0526@2|Bacteria,2G72F@200795|Chloroflexi,377HE@32061|Chloroflexia	32061|Chloroflexia	CO	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
SRD2_k127_386933_21	324602.Caur_0586	3.282e-32	137.0	COG0526@1|root,COG0526@2|Bacteria,2GACV@200795|Chloroflexi,375FU@32061|Chloroflexia	32061|Chloroflexia	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_2
SRD2_k127_386933_2	1298863.AUEP01000003_gene3186	1.345e-136	475.0	COG2366@1|root,COG2366@2|Bacteria,2GKEN@201174|Actinobacteria,4DPY6@85009|Propionibacteriales	201174|Actinobacteria	S	Penicillin amidase	pacB3	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,Penicil_amidase
SRD2_k127_386933_1	1120936.KB907215_gene3950	4.31e-221	734.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,Big_2,CBM_25,Calx-beta,DUF4114,P_proprotein,Peptidase_S8,SBBP,SLH,VCBS
SRD2_k127_386933_11	1229780.BN381_80063	6.207e-64	233.0	COG0036@1|root,COG0036@2|Bacteria,2GJZ9@201174|Actinobacteria,3UWJU@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	G	Ribulose-phosphate 3 epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
SRD2_k127_386933_14	1380346.JNIH01000006_gene3507	2.031e-54	202.0	COG0382@1|root,COG0382@2|Bacteria,2GJT3@201174|Actinobacteria	201174|Actinobacteria	H	Pfam UbiA prenyltransferase	ubiA	-	-	-	-	-	-	-	-	-	-	-	UbiA
SRD2_k127_386933_16	1382306.JNIM01000001_gene152	2.809e-50	192.0	COG0208@1|root,COG0208@2|Bacteria	2|Bacteria	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	-	-	1.17.4.1	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_sm
SRD2_k127_386933_24	1386969.AWTB01000097_gene4408	1.778e-21	100.0	COG0071@1|root,COG0071@2|Bacteria,2IHVJ@201174|Actinobacteria,4GDZA@85026|Gordoniaceae	201174|Actinobacteria	O	Hsp20/alpha crystallin family	hsp18	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
SRD2_k127_386933_5	525904.Tter_2296	1.244e-93	317.0	COG0484@1|root,COG0484@2|Bacteria,2NQI8@2323|unclassified Bacteria	2|Bacteria	O	DnaJ molecular chaperone homology domain	cbpA	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
SRD2_k127_386933_27	663278.Ethha_2190	2.101e-14	86.0	COG2340@1|root,COG2340@2|Bacteria,1V6GZ@1239|Firmicutes,24BAQ@186801|Clostridia,3WJQ5@541000|Ruminococcaceae	186801|Clostridia	M	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP,LysM
SRD2_k127_386933_20	1122939.ATUD01000007_gene1988	1.088e-33	135.0	COG1733@1|root,COG1733@2|Bacteria,2IQWP@201174|Actinobacteria,4CQQK@84995|Rubrobacteria	84995|Rubrobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
SRD2_k127_386933_15	566461.SSFG_00186	2.443e-51	188.0	COG2353@1|root,COG2353@2|Bacteria,2GJUB@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
SRD2_k127_386933_17	1118054.CAGW01000108_gene3647	2.842e-42	164.0	COG0730@1|root,COG0730@2|Bacteria,1TQBK@1239|Firmicutes,4HBCW@91061|Bacilli,26U6D@186822|Paenibacillaceae	91061|Bacilli	S	membrane transporter protein	yfcA	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
SRD2_k127_386933_13	1123023.JIAI01000029_gene4468	1.976e-60	224.0	COG0659@1|root,COG0659@2|Bacteria,2H1V9@201174|Actinobacteria	201174|Actinobacteria	P	Molybdate transporter of MFS superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_MOT1
SRD2_k127_386933_23	1120949.KB903294_gene4481	6.653e-24	108.0	2B8DK@1|root,321NI@2|Bacteria,2H5SG@201174|Actinobacteria,4DMAY@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_386933_30	1349820.M707_22225	6.265e-07	62.0	2DB8V@1|root,2Z7SX@2|Bacteria,2IA72@201174|Actinobacteria	201174|Actinobacteria	S	Gluconate 2-dehydrogenase subunit 3	-	-	1.1.99.3	ko:K06152	ko00030,ko01100,ko01120,map00030,map01100,map01120	-	R01741	RC00084	ko00000,ko00001,ko01000	-	-	-	Gluconate_2-dh3
SRD2_k127_386933_29	926562.Oweho_2464	8.698e-11	76.0	COG4409@1|root,COG4409@2|Bacteria,4PBA1@976|Bacteroidetes,1ICPD@117743|Flavobacteriia,2PBHN@246874|Cryomorphaceae	976|Bacteroidetes	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_386933_6	1101188.KI912157_gene155	3.464e-82	297.0	COG2303@1|root,COG2303@2|Bacteria,2I5YA@201174|Actinobacteria	201174|Actinobacteria	E	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
SRD2_k127_3939927_1	1094980.Mpsy_0927	4.026e-119	390.0	COG0439@1|root,arCOG01590@2157|Archaea,2Y8CM@28890|Euryarchaeota,2N91K@224756|Methanomicrobia	224756|Methanomicrobia	I	Carbamoyl-phosphate synthetase large chain domain protein	pycA	-	6.4.1.1	ko:K01959	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	BPL_C,BPL_LplA_LipB,Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
SRD2_k127_3939927_6	234267.Acid_1793	2.314e-08	63.0	2DB97@1|root,33TRP@2|Bacteria,3Y7NY@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_3939927_0	331869.BAL199_03824	9.75e-152	491.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2TQUE@28211|Alphaproteobacteria,4BPJK@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
SRD2_k127_3939927_2	1123371.ATXH01000013_gene1529	5.749e-105	349.0	COG0152@1|root,COG0152@2|Bacteria,2GH07@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
SRD2_k127_3939927_5	479434.Sthe_1291	1.755e-19	93.0	COG1828@1|root,COG1828@2|Bacteria,2GBWK@200795|Chloroflexi,27YN2@189775|Thermomicrobia	189775|Thermomicrobia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
SRD2_k127_3939927_3	697281.Mahau_1635	4.229e-93	314.0	COG0047@1|root,COG0047@2|Bacteria,1TP1B@1239|Firmicutes,24A2E@186801|Clostridia,42EVD@68295|Thermoanaerobacterales	186801|Clostridia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
SRD2_k127_3939927_4	479434.Sthe_1289	1.003e-78	274.0	COG0046@1|root,COG0046@2|Bacteria,2G5Z1@200795|Chloroflexi,27XNA@189775|Thermomicrobia	189775|Thermomicrobia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
SRD2_k127_4011776_0	1246995.AFR_33470	2.35e-125	419.0	COG2148@1|root,COG2148@2|Bacteria,2GK0M@201174|Actinobacteria,4D9NF@85008|Micromonosporales	201174|Actinobacteria	M	Sugar transferases involved in lipopolysaccharide synthesis	rfbP	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
SRD2_k127_4011776_1	1122939.ATUD01000005_gene2682	3.139e-05	54.0	COG0438@1|root,COG0438@2|Bacteria,2HEVG@201174|Actinobacteria,4CSMZ@84995|Rubrobacteria	84995|Rubrobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
SRD2_k127_4018324_0	1394178.AWOO02000054_gene8016	9.007e-89	300.0	COG2120@1|root,COG2120@2|Bacteria,2GIUS@201174|Actinobacteria,4EFVW@85012|Streptosporangiales	201174|Actinobacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
SRD2_k127_4018324_1	314275.MADE_1001415	1.204e-12	75.0	COG0551@1|root,COG1787@1|root,COG0551@2|Bacteria,COG1787@2|Bacteria,1RAHG@1224|Proteobacteria,1RYIV@1236|Gammaproteobacteria,4666S@72275|Alteromonadaceae	1236|Gammaproteobacteria	LV	Protein of unknown function (DUF2034)	mrr	-	-	ko:K07448	-	-	-	-	ko00000,ko02048	-	-	-	Mrr_cat,zf-C4_Topoisom
SRD2_k127_4029541_8	1146883.BLASA_5012	3.096e-49	191.0	COG1403@1|root,COG1403@2|Bacteria,2GU7G@201174|Actinobacteria,4EV73@85013|Frankiales	201174|Actinobacteria	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
SRD2_k127_4029541_13	1054860.KB913030_gene263	2.483e-29	129.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,GerE
SRD2_k127_4029541_0	448385.sce4570	5.838e-297	930.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WJRZ@28221|Deltaproteobacteria,2YW7G@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2101	PEP-utilizers,PEP-utilizers_C,PPDK_N
SRD2_k127_4029541_6	1220534.B655_1297	1.982e-73	261.0	arCOG12322@1|root,arCOG12322@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_4029541_7	479434.Sthe_1882	1.318e-49	188.0	COG4758@1|root,COG4758@2|Bacteria,2G93M@200795|Chloroflexi	200795|Chloroflexi	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_4029541_4	357808.RoseRS_2761	1.543e-111	376.0	COG1020@1|root,COG1020@2|Bacteria,2G7PI@200795|Chloroflexi	200795|Chloroflexi	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
SRD2_k127_4029541_9	926560.KE387027_gene351	1.057e-47	192.0	COG4832@1|root,COG4832@2|Bacteria	2|Bacteria	S	GyrI-like small molecule binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
SRD2_k127_4029541_5	1191523.MROS_2233	2.697e-98	331.0	COG0205@1|root,COG0205@2|Bacteria	2|Bacteria	G	6-phosphofructokinase activity	pfkA	-	2.7.1.11,2.7.1.90	ko:K00850,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
SRD2_k127_4029541_14	525909.Afer_1115	4.47e-10	70.0	2BM3X@1|root,32FM8@2|Bacteria,2HH03@201174|Actinobacteria,4CP0F@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_4029541_3	266117.Rxyl_0056	1.296e-149	481.0	COG1064@1|root,COG1064@2|Bacteria,2GNVQ@201174|Actinobacteria,4CPC1@84995|Rubrobacteria	84995|Rubrobacteria	S	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N
SRD2_k127_4029541_12	42256.RradSPS_0162	2.066e-36	149.0	COG1073@1|root,COG1073@2|Bacteria,2HPEF@201174|Actinobacteria,4CQSJ@84995|Rubrobacteria	84995|Rubrobacteria	S	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
SRD2_k127_4029541_10	35754.JNYJ01000014_gene4847	9.649e-45	184.0	COG1835@1|root,COG1835@2|Bacteria,2GKUS@201174|Actinobacteria,4DFGJ@85008|Micromonosporales	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
SRD2_k127_4029541_2	555079.Toce_2001	1.473e-164	531.0	COG2403@1|root,COG2403@2|Bacteria,1TPZD@1239|Firmicutes,24E2D@186801|Clostridia,42HSE@68295|Thermoanaerobacterales	186801|Clostridia	S	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
SRD2_k127_4029541_1	1370121.AUWS01000010_gene5916	5.599e-266	846.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,232MQ@1762|Mycobacteriaceae	201174|Actinobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
SRD2_k127_4029541_11	1449347.JQLN01000007_gene1837	1.658e-42	158.0	COG1290@1|root,COG1290@2|Bacteria,2GK58@201174|Actinobacteria	201174|Actinobacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_N_2
SRD2_k127_4046631_1	1234664.AMRO01000022_gene1652	6.152e-107	353.0	COG1028@1|root,COG1028@2|Bacteria,1V14I@1239|Firmicutes,4HCT7@91061|Bacilli,1WFZ8@129337|Geobacillus	91061|Bacilli	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
SRD2_k127_4046631_6	446470.Snas_6364	6.352e-24	106.0	COG2030@1|root,COG2030@2|Bacteria,2IFCJ@201174|Actinobacteria,4EYS6@85014|Glycomycetales	201174|Actinobacteria	I	MaoC like domain	hadB	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
SRD2_k127_4046631_8	1111479.AXAR01000001_gene75	5.234e-11	69.0	COG2030@1|root,COG2030@2|Bacteria,1V4PQ@1239|Firmicutes,4HGYW@91061|Bacilli,278N3@186823|Alicyclobacillaceae	91061|Bacilli	I	N-terminal half of MaoC dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N
SRD2_k127_4046631_4	1121422.AUMW01000018_gene1909	5.312e-32	127.0	COG3255@1|root,COG3255@2|Bacteria,1VFEY@1239|Firmicutes,24QXQ@186801|Clostridia,263BY@186807|Peptococcaceae	186801|Clostridia	I	sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
SRD2_k127_4046631_7	468556.AQYG01000047_gene1617	1.205e-13	80.0	COG2867@1|root,COG2867@2|Bacteria,2I47G@201174|Actinobacteria,4GH8A@85026|Gordoniaceae	201174|Actinobacteria	I	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
SRD2_k127_4046631_0	1382306.JNIM01000001_gene3513	5.298e-158	511.0	COG0334@1|root,COG0334@2|Bacteria,2G5SR@200795|Chloroflexi	200795|Chloroflexi	C	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
SRD2_k127_4046631_3	1235797.C816_00788	1.152e-57	216.0	COG0745@1|root,COG0745@2|Bacteria,1TPQG@1239|Firmicutes,248Z4@186801|Clostridia,2N6Q4@216572|Oscillospiraceae	186801|Clostridia	T	Transcriptional regulatory protein, C terminal	walR	-	-	ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SRD2_k127_4046631_2	1173264.KI913949_gene1024	1.199e-80	290.0	COG0642@1|root,COG2202@1|root,COG2203@1|root,COG2905@1|root,COG2964@1|root,COG4251@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG2905@2|Bacteria,COG2964@2|Bacteria,COG4251@2|Bacteria,COG5002@2|Bacteria,1G09B@1117|Cyanobacteria,1H71H@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
SRD2_k127_4046631_5	1430331.EP10_09380	3.861e-30	128.0	COG2003@1|root,COG2003@2|Bacteria,1TQ3K@1239|Firmicutes,4HB1W@91061|Bacilli,1WFJ7@129337|Geobacillus	91061|Bacilli	E	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
SRD2_k127_4054560_28	1048834.TC41_3036	7.374e-26	117.0	COG0091@1|root,COG0091@2|Bacteria,1V6PU@1239|Firmicutes,4HIK2@91061|Bacilli,278GN@186823|Alicyclobacillaceae	91061|Bacilli	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
SRD2_k127_4054560_7	1089553.Tph_c25790	6.919e-76	269.0	COG0092@1|root,COG0092@2|Bacteria,1TPCP@1239|Firmicutes,24833@186801|Clostridia,42ERW@68295|Thermoanaerobacterales	186801|Clostridia	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
SRD2_k127_4054560_14	908338.HMPREF9286_0235	1.386e-60	211.0	COG0197@1|root,COG0197@2|Bacteria,1V1AY@1239|Firmicutes,24FQX@186801|Clostridia,22H73@1570339|Peptoniphilaceae	186801|Clostridia	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
SRD2_k127_4054560_36	1169161.KB897717_gene3178	6.293e-13	76.0	COG0255@1|root,COG0255@2|Bacteria,2IQ6V@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the universal ribosomal protein uL29 family	rpmC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
SRD2_k127_4054560_30	1121430.JMLG01000033_gene1340	8.579e-24	112.0	COG0186@1|root,COG0186@2|Bacteria,1V9YC@1239|Firmicutes,24MSW@186801|Clostridia,262K7@186807|Peptococcaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
SRD2_k127_4054560_17	1280681.AUJZ01000002_gene1236	6.352e-54	192.0	COG0093@1|root,COG0093@2|Bacteria,1V3N0@1239|Firmicutes,24H98@186801|Clostridia,4BZCB@830|Butyrivibrio	186801|Clostridia	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
SRD2_k127_4054560_29	515635.Dtur_0992	8.613e-25	113.0	COG0198@1|root,COG0198@2|Bacteria	2|Bacteria	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
SRD2_k127_4054560_8	521098.Aaci_2699	9.924e-76	265.0	COG0094@1|root,COG0094@2|Bacteria,1TPE0@1239|Firmicutes,4HBAX@91061|Bacilli,278A4@186823|Alicyclobacillaceae	91061|Bacilli	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
SRD2_k127_4054560_31	760568.Desku_3044	1.051e-23	101.0	COG0199@1|root,COG0199@2|Bacteria,1VEF6@1239|Firmicutes,24QR1@186801|Clostridia,262RF@186807|Peptococcaceae	186801|Clostridia	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
SRD2_k127_4054560_23	555079.Toce_0133	1.903e-42	159.0	COG0096@1|root,COG0096@2|Bacteria,1V3KK@1239|Firmicutes,24HCP@186801|Clostridia,42G9H@68295|Thermoanaerobacterales	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
SRD2_k127_4054560_11	521098.Aaci_2696	5.597e-66	229.0	COG0097@1|root,COG0097@2|Bacteria,1V1FC@1239|Firmicutes,4HFQD@91061|Bacilli,2793R@186823|Alicyclobacillaceae	91061|Bacilli	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
SRD2_k127_4054560_25	515635.Dtur_0997	3.68e-33	134.0	COG0256@1|root,COG0256@2|Bacteria	2|Bacteria	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
SRD2_k127_4054560_13	370438.PTH_0336	6.53e-61	221.0	COG0098@1|root,COG0098@2|Bacteria,1V1B1@1239|Firmicutes,24G5D@186801|Clostridia,261HV@186807|Peptococcaceae	186801|Clostridia	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
SRD2_k127_4054560_35	383372.Rcas_4008	9.243e-16	79.0	COG1841@1|root,COG1841@2|Bacteria,2G7E7@200795|Chloroflexi,375Z1@32061|Chloroflexia	32061|Chloroflexia	J	PFAM ribosomal protein L30	rpmD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
SRD2_k127_4054560_19	471223.GWCH70_0130	1.535e-47	179.0	COG0200@1|root,COG0200@2|Bacteria,1V3KE@1239|Firmicutes,4HFPW@91061|Bacilli,1WGA3@129337|Geobacillus	91061|Bacilli	J	Binds to the 23S rRNA	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
SRD2_k127_4054560_1	335541.Swol_2313	6.035e-120	399.0	COG0201@1|root,COG0201@2|Bacteria,1TPHB@1239|Firmicutes,248T9@186801|Clostridia,42JP8@68298|Syntrophomonadaceae	186801|Clostridia	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
SRD2_k127_4054560_15	926569.ANT_10250	2.53e-60	216.0	COG0563@1|root,COG0563@2|Bacteria,2G6GP@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
SRD2_k127_4054560_5	997346.HMPREF9374_2869	3.081e-87	295.0	COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,4H9S9@91061|Bacilli,27B7R@186824|Thermoactinomycetaceae	91061|Bacilli	J	Metallopeptidase family M24	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
SRD2_k127_4054560_32	457570.Nther_0218	5.91e-21	94.0	COG0361@1|root,COG0361@2|Bacteria,1V9ZK@1239|Firmicutes,24MQE@186801|Clostridia	186801|Clostridia	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
SRD2_k127_4054560_37	572265.HDEF_1845	4.625e-12	66.0	COG0257@1|root,COG0257@2|Bacteria,1NGEI@1224|Proteobacteria,1SGC9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
SRD2_k127_4054560_18	768704.Desmer_0271	2.38e-48	175.0	COG0099@1|root,COG0099@2|Bacteria,1V3JH@1239|Firmicutes,24HCT@186801|Clostridia,261QX@186807|Peptococcaceae	186801|Clostridia	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
SRD2_k127_4054560_16	485913.Krac_12503	1.293e-59	208.0	COG0100@1|root,COG0100@2|Bacteria,2G6HG@200795|Chloroflexi	200795|Chloroflexi	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
SRD2_k127_4054560_10	1121423.JONT01000027_gene633	4.56e-66	233.0	COG0522@1|root,COG0522@2|Bacteria,1TR0J@1239|Firmicutes,248Y5@186801|Clostridia,260U9@186807|Peptococcaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
SRD2_k127_4054560_2	1382306.JNIM01000001_gene3521	1.649e-99	338.0	COG0202@1|root,COG0202@2|Bacteria,2G5M9@200795|Chloroflexi	200795|Chloroflexi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
SRD2_k127_4054560_26	1535422.ND16A_2747	1.313e-30	124.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,1S3QK@1236|Gammaproteobacteria,2Q6TI@267889|Colwelliaceae	1236|Gammaproteobacteria	J	Ribosomal protein L17	rplQ	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
SRD2_k127_4054560_22	1144275.COCOR_02382	2.291e-43	169.0	COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,42RTC@68525|delta/epsilon subdivisions,2WNQ6@28221|Deltaproteobacteria,2YVHB@29|Myxococcales	28221|Deltaproteobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
SRD2_k127_4054560_21	479434.Sthe_1067	2.083e-46	173.0	COG0102@1|root,COG0102@2|Bacteria,2G6M4@200795|Chloroflexi,27YCR@189775|Thermomicrobia	189775|Thermomicrobia	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
SRD2_k127_4054560_24	656024.FsymDg_3928	3.482e-37	146.0	COG0103@1|root,COG0103@2|Bacteria,2GNDY@201174|Actinobacteria,4ESQW@85013|Frankiales	201174|Actinobacteria	J	Belongs to the universal ribosomal protein uS9 family	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
SRD2_k127_4054560_4	42256.RradSPS_2301	5.427e-91	308.0	COG0078@1|root,COG0078@2|Bacteria,2GJ6H@201174|Actinobacteria,4CPYJ@84995|Rubrobacteria	84995|Rubrobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	-	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
SRD2_k127_4054560_12	264732.Moth_2248	5.163e-62	224.0	COG1624@1|root,COG1624@2|Bacteria,1TPRW@1239|Firmicutes,249K8@186801|Clostridia,42FDQ@68295|Thermoanaerobacterales	186801|Clostridia	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
SRD2_k127_4054560_34	760568.Desku_2882	1.606e-16	91.0	COG4856@1|root,COG4856@2|Bacteria,1TSIV@1239|Firmicutes,24GKC@186801|Clostridia,2612S@186807|Peptococcaceae	186801|Clostridia	S	PFAM YbbR-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
SRD2_k127_4054560_0	1121472.AQWN01000001_gene281	2.133e-181	587.0	COG0449@1|root,COG0449@2|Bacteria,1TPGU@1239|Firmicutes,248F8@186801|Clostridia,2608Z@186807|Peptococcaceae	186801|Clostridia	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
SRD2_k127_4054560_9	552811.Dehly_0249	4.698e-69	249.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2G5Y8@200795|Chloroflexi,34D4S@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
SRD2_k127_4054560_3	1121468.AUBR01000001_gene578	5.086e-94	321.0	COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,42EZ0@68295|Thermoanaerobacterales	186801|Clostridia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
SRD2_k127_4054560_6	351607.Acel_1842	3.353e-83	283.0	COG1611@1|root,COG1611@2|Bacteria,2GKJH@201174|Actinobacteria,4ERSK@85013|Frankiales	201174|Actinobacteria	S	Belongs to the LOG family	fmt2	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
SRD2_k127_4054560_27	525904.Tter_2592	5.179e-27	123.0	COG0215@1|root,COG1216@1|root,COG0215@2|Bacteria,COG1216@2|Bacteria,2NNP0@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16,6.3.1.13	ko:K01883,ko:K15526	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
SRD2_k127_4054560_33	543632.JOJL01000002_gene8239	5.901e-17	93.0	COG2508@1|root,COG2508@2|Bacteria,2I8HD@201174|Actinobacteria	201174|Actinobacteria	QT	transcriptional regulator, PucR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_30
SRD2_k127_4054560_20	1000565.METUNv1_00289	1.915e-47	181.0	COG1633@1|root,COG1633@2|Bacteria,1MXX8@1224|Proteobacteria,2VI3H@28216|Betaproteobacteria,2KXZR@206389|Rhodocyclales	206389|Rhodocyclales	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_4057329_11	196162.Noca_1531	6.899e-67	242.0	COG0477@1|root,COG0477@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	mdtH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06610,ko:K08162	-	-	-	-	ko00000,ko02000	2.A.1.1.27,2.A.1.2.21	-	-	MFS_1,Sugar_tr
SRD2_k127_4057329_3	309801.trd_A0525	4.799e-131	450.0	COG0587@1|root,COG0587@2|Bacteria,2G811@200795|Chloroflexi,27Z3J@189775|Thermomicrobia	189775|Thermomicrobia	L	Belongs to the DNA polymerase type-C family. DnaE2 subfamily	-	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
SRD2_k127_4057329_6	1386089.N865_17320	1.123e-78	296.0	COG0642@1|root,COG2205@2|Bacteria,2GJKC@201174|Actinobacteria,4FEB6@85021|Intrasporangiaceae	201174|Actinobacteria	T	Osmosensitive K+ channel His kinase sensor domain	kdpD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA,KdpD,Usp
SRD2_k127_4057329_1	525904.Tter_0032	4.171e-180	589.0	COG0531@1|root,COG0531@2|Bacteria,2NNZQ@2323|unclassified Bacteria	2|Bacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
SRD2_k127_4057329_5	42256.RradSPS_0667	9.728e-81	289.0	COG0463@1|root,COG2203@1|root,COG2246@1|root,COG0463@2|Bacteria,COG2203@2|Bacteria,COG2246@2|Bacteria,2I4BA@201174|Actinobacteria,4CU4V@84995|Rubrobacteria	84995|Rubrobacteria	MT	glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,GtrA
SRD2_k127_4057329_18	357809.Cphy_1688	7.856e-17	91.0	COG4447@1|root,COG4447@2|Bacteria,1UU3Y@1239|Firmicutes,24C6F@186801|Clostridia	186801|Clostridia	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_4057329_10	485913.Krac_6839	5.18e-68	242.0	COG1606@1|root,COG1606@2|Bacteria,2G6AU@200795|Chloroflexi	200795|Chloroflexi	L	tRNA processing	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	Asn_synthase,NAD_synthase
SRD2_k127_4057329_9	1430440.MGMSRv2_2886	5.058e-68	241.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2TRWY@28211|Alphaproteobacteria,2JQG1@204441|Rhodospirillales	204441|Rhodospirillales	H	COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2	moeB	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
SRD2_k127_4057329_15	395495.Lcho_2453	6.408e-40	166.0	COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,2VHE9@28216|Betaproteobacteria,1KK8W@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	enoyl-CoA hydratase isomerase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
SRD2_k127_4057329_2	717605.Theco_0520	9.214e-170	547.0	COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,4H9ZF@91061|Bacilli,26QJT@186822|Paenibacillaceae	91061|Bacilli	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
SRD2_k127_4057329_12	1128421.JAGA01000001_gene2079	5.715e-48	193.0	COG4346@1|root,COG4346@2|Bacteria	2|Bacteria	O	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	GT87,PMT,PMT_2,PMT_4TMC
SRD2_k127_4057329_14	351160.RRC427	2.879e-42	176.0	COG5427@1|root,arCOG00563@2157|Archaea	2157|Archaea	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2298
SRD2_k127_4057329_7	42256.RradSPS_2504	1.252e-71	252.0	COG1707@1|root,COG1707@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K06862	-	-	-	-	ko00000	-	-	-	ACT
SRD2_k127_4057329_16	269797.Mbar_A2190	3.823e-27	123.0	COG0483@1|root,arCOG01349@2157|Archaea,2XUBB@28890|Euryarchaeota,2N9NZ@224756|Methanomicrobia	224756|Methanomicrobia	G	PFAM Inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
SRD2_k127_4057329_8	264732.Moth_1935	4.12e-71	256.0	COG1085@1|root,COG1085@2|Bacteria,1TS3F@1239|Firmicutes,249P3@186801|Clostridia,42F43@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Galactose-1-phosphate uridyl transferase	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4921,DUF4931,GalP_UDP_tr_C,GalP_UDP_transf
SRD2_k127_4057329_17	391625.PPSIR1_41739	1.003e-21	111.0	COG3356@1|root,COG3356@2|Bacteria,1Q66U@1224|Proteobacteria,4358C@68525|delta/epsilon subdivisions,2WZJF@28221|Deltaproteobacteria,2Z29I@29|Myxococcales	28221|Deltaproteobacteria	S	Neutral/alkaline non-lysosomal ceramidase, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
SRD2_k127_4057329_0	1298863.AUEP01000003_gene3186	1.429e-270	863.0	COG2366@1|root,COG2366@2|Bacteria,2GKEN@201174|Actinobacteria,4DPY6@85009|Propionibacteriales	201174|Actinobacteria	S	Penicillin amidase	pacB3	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,Penicil_amidase
SRD2_k127_4057329_13	304371.MCP_0389	3.833e-44	175.0	arCOG11014@1|root,arCOG11014@2157|Archaea,2XZ0A@28890|Euryarchaeota	2157|Archaea	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
SRD2_k127_4057329_4	1144275.COCOR_06374	7.055e-84	292.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,430V0@68525|delta/epsilon subdivisions,2WVT6@28221|Deltaproteobacteria,2YXP7@29|Myxococcales	28221|Deltaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9
SRD2_k127_4075802_6	1458275.AZ34_07530	3.32e-91	310.0	COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,2VHCR@28216|Betaproteobacteria,4AAI7@80864|Comamonadaceae	28216|Betaproteobacteria	S	FAD dependent oxidoreductase	-	-	-	ko:K06954	-	-	-	-	ko00000	-	-	-	Amino_oxidase
SRD2_k127_4075802_11	469383.Cwoe_4723	7.022e-55	213.0	COG3496@1|root,COG3496@2|Bacteria,2HR57@201174|Actinobacteria,4CT0I@84995|Rubrobacteria	84995|Rubrobacteria	S	Protein of unknown function (DUF1365)	-	-	-	ko:K09701	-	-	-	-	ko00000	-	-	-	DUF1365
SRD2_k127_4075802_3	1149133.ppKF707_0121	8.937e-118	406.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1RNID@1236|Gammaproteobacteria,1YCSC@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	Mycolic acid cyclopropane synthetase	cfa	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	iJN746.PP_2734	CMAS
SRD2_k127_4075802_1	1121939.L861_14950	8.481e-138	452.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,1RRDD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
SRD2_k127_4075802_7	1304865.JAGF01000001_gene2934	2.675e-86	326.0	2EZYF@1|root,33T2N@2|Bacteria,2H3P5@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_4075802_25	1170318.PALO_08110	3.729e-08	66.0	COG2339@1|root,COG2339@2|Bacteria,2GKR5@201174|Actinobacteria,4DQ3Y@85009|Propionibacteriales	201174|Actinobacteria	S	Protease prsW family	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
SRD2_k127_4075802_18	698769.JFBD01000091_gene2184	5.241e-41	164.0	COG1073@1|root,COG1073@2|Bacteria,1TQYU@1239|Firmicutes,4HC4H@91061|Bacilli	91061|Bacilli	D	Alpha beta	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
SRD2_k127_4075802_5	1303518.CCALI_00699	7.545e-95	323.0	COG4320@1|root,COG4320@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
SRD2_k127_4075802_21	1089551.KE386572_gene2875	2.822e-27	123.0	COG1940@1|root,COG1940@2|Bacteria	2|Bacteria	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
SRD2_k127_4075802_12	1122604.JONR01000011_gene3685	1.193e-52	194.0	COG0546@1|root,COG0546@2|Bacteria,1QEY0@1224|Proteobacteria,1S385@1236|Gammaproteobacteria,1X6BW@135614|Xanthomonadales	135614|Xanthomonadales	S	phosphoglycolate phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_4075802_17	512565.AMIS_36880	2.009e-41	161.0	COG2204@1|root,COG3829@1|root,COG4191@1|root,COG2204@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,2GZ7K@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,Response_reg
SRD2_k127_4075802_2	765420.OSCT_1231	3.427e-120	396.0	COG3437@1|root,COG3437@2|Bacteria,2G6QF@200795|Chloroflexi,37587@32061|Chloroflexia	200795|Chloroflexi	KT	metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
SRD2_k127_4075802_8	96561.Dole_3268	2.403e-68	258.0	COG0784@1|root,COG2202@1|root,COG3275@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3275@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria,2MI5F@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3
SRD2_k127_4075802_22	512565.AMIS_69920	8.91e-22	111.0	COG3852@1|root,COG4191@1|root,COG3852@2|Bacteria,COG4191@2|Bacteria,2GZ7K@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_9,Response_reg
SRD2_k127_4075802_4	247490.KSU1_C0316	9.719e-103	358.0	COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,2J515@203682|Planctomycetes	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_3,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_7,PAS_8,PAS_9,Response_reg
SRD2_k127_4075802_23	1163408.UU9_05029	1.215e-15	86.0	COG0745@1|root,COG0784@1|root,COG5002@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,1SVEC@1236|Gammaproteobacteria,1XDBG@135614|Xanthomonadales	135614|Xanthomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HAMP,HATPase_c,HisKA,Response_reg
SRD2_k127_4075802_16	1120949.KB903297_gene5524	5.938e-42	164.0	COG0266@1|root,COG0266@2|Bacteria,2GKAM@201174|Actinobacteria,4DBAI@85008|Micromonosporales	201174|Actinobacteria	L	Belongs to the FPG family	mutM1	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
SRD2_k127_4075802_9	316274.Haur_2614	1.193e-63	227.0	COG1028@1|root,COG1028@2|Bacteria,2G5KB@200795|Chloroflexi,3759E@32061|Chloroflexia	316274.Haur_2614|-	IQ	short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_4075802_20	861299.J421_6190	9.287e-32	135.0	2D9QC@1|root,336IT@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_4075802_13	1382306.JNIM01000001_gene3094	1.415e-48	186.0	COG1309@1|root,COG1309@2|Bacteria,2G7DR@200795|Chloroflexi	200795|Chloroflexi	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_4,TetR_N
SRD2_k127_4075802_15	479434.Sthe_1779	7.171e-46	186.0	COG1807@1|root,COG1807@2|Bacteria,2GBE9@200795|Chloroflexi,27Z44@189775|Thermomicrobia	189775|Thermomicrobia	M	Protein of unknown function (DUF2723)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723
SRD2_k127_4075802_19	525904.Tter_1414	2.51e-32	134.0	COG2802@1|root,COG2802@2|Bacteria,2NPRK@2323|unclassified Bacteria	2|Bacteria	S	ATP-dependent protease La (LON) substrate-binding domain	lonD	-	3.4.21.53	ko:K01338,ko:K07157	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
SRD2_k127_4075802_26	545694.TREPR_1626	0.0007921	51.0	COG1595@1|root,COG1595@2|Bacteria,2J64C@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SRD2_k127_4075802_14	926550.CLDAP_03620	4.66e-46	177.0	COG0062@1|root,COG0062@2|Bacteria,2G8T6@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX	-	-	5.1.99.6	ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	YjeF_N
SRD2_k127_4075802_0	1122223.KB890691_gene2351	1.045e-180	580.0	COG0148@1|root,COG0148@2|Bacteria,1WIST@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
SRD2_k127_4075802_10	1123024.AUII01000009_gene2016	3.596e-57	221.0	COG4221@1|root,COG4221@2|Bacteria,2GQNJ@201174|Actinobacteria,4DXKH@85010|Pseudonocardiales	201174|Actinobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SRD2_k127_4075802_24	765420.OSCT_2727	1.11e-09	69.0	COG1716@1|root,COG1716@2|Bacteria,2G9CS@200795|Chloroflexi,375YC@32061|Chloroflexia	32061|Chloroflexia	T	PFAM Forkhead-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	FHA
SRD2_k127_4076081_4	1210884.HG799473_gene14915	9.573e-05	49.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
SRD2_k127_4076081_1	1254432.SCE1572_36400	1.089e-36	154.0	COG1484@1|root,COG1484@2|Bacteria,1MVU2@1224|Proteobacteria,42PXQ@68525|delta/epsilon subdivisions,2WKHU@28221|Deltaproteobacteria,2YZ37@29|Myxococcales	28221|Deltaproteobacteria	L	COG1484 DNA replication protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
SRD2_k127_4076081_0	1121468.AUBR01000052_gene1614	1.483e-67	253.0	COG4584@1|root,COG4584@2|Bacteria,1TR5X@1239|Firmicutes,25D02@186801|Clostridia,42FJ4@68295|Thermoanaerobacterales	186801|Clostridia	L	COGs COG4584 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,Mu-transpos_C,rve
SRD2_k127_4076081_3	1121422.AUMW01000047_gene1234	1.036e-10	73.0	COG1475@1|root,COG1475@2|Bacteria	2|Bacteria	K	chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	ParBc
SRD2_k127_4094754_0	710696.Intca_1367	2.077e-35	142.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria	201174|Actinobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit	acoB	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
SRD2_k127_4094754_2	47716.JOFH01000014_gene5791	6.261e-11	71.0	COG0745@1|root,COG0745@2|Bacteria,2GK5S@201174|Actinobacteria	201174|Actinobacteria	T	response regulator, receiver	resD	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
SRD2_k127_4094754_1	485913.Krac_10254	1.265e-25	122.0	COG0628@1|root,COG0628@2|Bacteria,2G6TV@200795|Chloroflexi	200795|Chloroflexi	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
SRD2_k127_4094754_3	1056816.JAFQ01000003_gene7266	3.695e-08	62.0	COG0745@1|root,COG0745@2|Bacteria,2GK5S@201174|Actinobacteria,4FYYS@85025|Nocardiaceae	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	resD	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
SRD2_k127_4109362_4	1382358.JHVN01000003_gene2926	9.76e-07	61.0	COG1714@1|root,COG1714@2|Bacteria,1V6N5@1239|Firmicutes,4HJRB@91061|Bacilli	91061|Bacilli	S	Membrane	yckC	-	-	-	-	-	-	-	-	-	-	-	RDD
SRD2_k127_4109362_1	1128421.JAGA01000003_gene3532	1.373e-63	230.0	COG5032@1|root,COG5032@2|Bacteria,2NR1S@2323|unclassified Bacteria	2|Bacteria	BDLTU	phosphatidylinositol kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	PI3_PI4_kinase
SRD2_k127_4109362_3	1386089.N865_07875	3.091e-34	137.0	298YA@1|root,2ZW25@2|Bacteria,2GIYI@201174|Actinobacteria,4FGZE@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3090)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3090
SRD2_k127_4109362_2	1128421.JAGA01000003_gene3534	7.027e-54	197.0	COG0406@1|root,COG0406@2|Bacteria	2|Bacteria	G	alpha-ribazole phosphatase activity	-	-	3.1.3.3,3.1.3.73,5.4.2.12	ko:K02226,ko:K15634,ko:K22305	ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00122	R00582,R01518,R04594,R11173	RC00017,RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
SRD2_k127_4109362_0	635013.TherJR_0925	7.026e-83	278.0	COG0443@1|root,COG0443@2|Bacteria,1TP1J@1239|Firmicutes,248QV@186801|Clostridia,263XI@186807|Peptococcaceae	186801|Clostridia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
SRD2_k127_4111726_0	1521187.JPIM01000055_gene3643	3.586e-105	355.0	COG1752@1|root,COG1752@2|Bacteria,2G7GM@200795|Chloroflexi,374ZF@32061|Chloroflexia	32061|Chloroflexia	S	PFAM Patatin	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
SRD2_k127_4125872_0	247490.KSU1_C0508	1.249e-66	245.0	COG1361@1|root,COG1361@2|Bacteria,2IY9X@203682|Planctomycetes	203682|Planctomycetes	M	60 kDa outer membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
SRD2_k127_4137265_1	1136417.AZWE01000001_gene3752	1.363e-96	330.0	COG3239@1|root,COG3239@2|Bacteria,2GJKF@201174|Actinobacteria,4D9MG@85008|Micromonosporales	201174|Actinobacteria	I	Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
SRD2_k127_4137265_3	390989.JOEG01000001_gene5076	2.131e-68	239.0	COG3371@1|root,COG3371@2|Bacteria,2II34@201174|Actinobacteria,4DDK4@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
SRD2_k127_4137265_4	1120934.KB894403_gene318	2.403e-44	171.0	COG1309@1|root,COG1309@2|Bacteria,2IN8A@201174|Actinobacteria,4E5VD@85010|Pseudonocardiales	201174|Actinobacteria	K	AefR-like transcriptional repressor, C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_7,TetR_N
SRD2_k127_4137265_5	383372.Rcas_1384	1.944e-18	100.0	COG3356@1|root,COG3356@2|Bacteria,2G7ZP@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Neutral alkaline nonlysosomal ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_4137265_0	1347369.CCAD010000021_gene1619	3.099e-109	380.0	COG2936@1|root,COG2936@2|Bacteria,1TT0H@1239|Firmicutes,4HC37@91061|Bacilli,1ZE6G@1386|Bacillus	91061|Bacilli	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
SRD2_k127_4137265_2	926569.ANT_13370	2.887e-92	320.0	COG0464@1|root,COG0464@2|Bacteria,2G642@200795|Chloroflexi	200795|Chloroflexi	O	SMART AAA ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA
SRD2_k127_4140416_1	1382304.JNIL01000001_gene1532	1.095e-108	357.0	COG0379@1|root,COG0379@2|Bacteria,1TP6R@1239|Firmicutes,4H9QG@91061|Bacilli,279AN@186823|Alicyclobacillaceae	91061|Bacilli	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
SRD2_k127_4140416_3	309801.trd_1635	1.354e-35	141.0	COG1959@1|root,COG1959@2|Bacteria,2G8ZH@200795|Chloroflexi,27YCQ@189775|Thermomicrobia	189775|Thermomicrobia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
SRD2_k127_4140416_2	266117.Rxyl_0171	1.692e-101	343.0	COG0396@1|root,COG0396@2|Bacteria,2GKB7@201174|Actinobacteria,4CPSF@84995|Rubrobacteria	84995|Rubrobacteria	O	ATPases associated with a variety of cellular activities	-	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
SRD2_k127_4140416_0	525904.Tter_1698	3.964e-152	508.0	COG0719@1|root,COG0719@2|Bacteria,2NNKT@2323|unclassified Bacteria	2|Bacteria	O	FeS assembly protein SufB	sufB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360	-	ko:K07033,ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
SRD2_k127_4148875_17	525904.Tter_2591	4.026e-93	323.0	COG0276@1|root,COG0276@2|Bacteria,2NQ0V@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Chloroa_b-bind,Ferrochelatase
SRD2_k127_4148875_5	525904.Tter_2590	2.354e-151	496.0	COG0407@1|root,COG0407@2|Bacteria,2NP39@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0016	URO-D
SRD2_k127_4148875_1	246197.MXAN_0644	7.863e-169	561.0	COG0308@1|root,COG1413@1|root,COG0308@2|Bacteria,COG1413@2|Bacteria,1MUCI@1224|Proteobacteria,42KZI@68525|delta/epsilon subdivisions,2WJ2C@28221|Deltaproteobacteria,2YTZK@29|Myxococcales	28221|Deltaproteobacteria	CE	Peptidase family M1 domain	pepN	-	3.4.11.2	ko:K01256,ko:K08776	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,HEAT_2,Peptidase_M1
SRD2_k127_4148875_27	429009.Adeg_1311	4.611e-54	212.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,42EW8@68295|Thermoanaerobacterales	186801|Clostridia	KLT	Serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
SRD2_k127_4148875_23	1380390.JIAT01000006_gene6329	2.581e-69	245.0	COG1968@1|root,COG1968@2|Bacteria,2GJVG@201174|Actinobacteria,4CQ84@84995|Rubrobacteria	84995|Rubrobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	-	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
SRD2_k127_4148875_44	1123248.KB893381_gene1007	3.079e-11	76.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cupredoxin_1
SRD2_k127_4148875_3	272562.CA_C2873	5.75e-156	501.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,2482I@186801|Clostridia,36DVG@31979|Clostridiaceae	186801|Clostridia	I	Belongs to the thiolase family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
SRD2_k127_4148875_31	1121381.JNIV01000046_gene3152	5.565e-49	190.0	COG1960@1|root,COG1960@2|Bacteria,1WKVF@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_2,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SRD2_k127_4148875_9	644966.Tmar_1434	9.729e-129	425.0	COG0446@1|root,COG0446@2|Bacteria,1TRNN@1239|Firmicutes,25EM2@186801|Clostridia	186801|Clostridia	P	PFAM Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
SRD2_k127_4148875_28	1382305.AZUC01000017_gene2625	1.249e-52	197.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,4H9KP@91061|Bacilli,26DAH@186818|Planococcaceae	91061|Bacilli	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	phoP	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SRD2_k127_4148875_22	58123.JOFJ01000003_gene2212	1.77e-72	251.0	COG4122@1|root,COG4122@2|Bacteria,2GQ0Z@201174|Actinobacteria,4EIH4@85012|Streptosporangiales	201174|Actinobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
SRD2_k127_4148875_15	1121937.AUHJ01000008_gene1987	3.587e-95	324.0	COG3387@1|root,COG3387@2|Bacteria,1NB01@1224|Proteobacteria,1RS3W@1236|Gammaproteobacteria,46581@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	PFAM Glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans
SRD2_k127_4148875_19	1415166.NONO_c03390	4.858e-86	292.0	COG0500@1|root,COG2226@2|Bacteria,2H38T@201174|Actinobacteria,4FXIS@85025|Nocardiaceae	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
SRD2_k127_4148875_7	479433.Caci_2137	8.434e-146	473.0	COG0438@1|root,COG0438@2|Bacteria,2GMXE@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
SRD2_k127_4148875_41	435837.HMPREF0798_01167	4.4e-15	84.0	COG3942@1|root,COG3942@2|Bacteria,1TXKU@1239|Firmicutes,4I6KI@91061|Bacilli,4GXHV@90964|Staphylococcaceae	91061|Bacilli	S	secretory antigen	sceB	-	-	-	-	-	-	-	-	-	-	-	CHAP
SRD2_k127_4148875_43	1038860.AXAP01000002_gene4808	6.403e-13	72.0	2E36Z@1|root,32Y6R@2|Bacteria,1NCM6@1224|Proteobacteria,2UGU3@28211|Alphaproteobacteria,3K0A1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_4148875_14	1246995.AFR_18850	2.557e-103	348.0	COG0624@1|root,COG0624@2|Bacteria,2GMH2@201174|Actinobacteria,4DAAB@85008|Micromonosporales	201174|Actinobacteria	E	Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
SRD2_k127_4148875_6	526225.Gobs_4376	3.006e-151	509.0	COG2170@1|root,COG2170@2|Bacteria,2GKAA@201174|Actinobacteria,4ES1F@85013|Frankiales	201174|Actinobacteria	S	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	ybdK	-	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
SRD2_k127_4148875_30	1051632.TPY_1705	4.574e-49	191.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SRD2_k127_4148875_8	1382359.JIAL01000001_gene2221	1.531e-145	475.0	COG0624@1|root,COG0624@2|Bacteria,3Y3TZ@57723|Acidobacteria,2JIUW@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
SRD2_k127_4148875_46	1229781.C272_11113	1.248e-05	53.0	COG3339@1|root,COG3339@2|Bacteria,2IMW8@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
SRD2_k127_4148875_37	521098.Aaci_2925	4.846e-31	128.0	COG0359@1|root,COG0359@2|Bacteria,1V6QG@1239|Firmicutes,4HIKJ@91061|Bacilli,27A64@186823|Alicyclobacillaceae	91061|Bacilli	J	Binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
SRD2_k127_4148875_11	935948.KE386495_gene1689	1.153e-127	422.0	COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,42FJ3@68295|Thermoanaerobacterales	186801|Clostridia	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
SRD2_k127_4148875_10	1206741.BAFX01000141_gene2710	4.48e-128	441.0	COG0104@1|root,COG0104@2|Bacteria,2GMP4@201174|Actinobacteria,4FW5P@85025|Nocardiaceae	201174|Actinobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
SRD2_k127_4148875_25	58123.JOFJ01000002_gene2433	1.652e-61	227.0	COG0265@1|root,COG0265@2|Bacteria,2GJ92@201174|Actinobacteria,4EHJ9@85012|Streptosporangiales	201174|Actinobacteria	O	Colicin V production protein	cvpA	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009268,GO:0009405,GO:0009628,GO:0010447,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	Colicin_V,Trypsin_2
SRD2_k127_4148875_39	1265313.HRUBRA_02709	1.644e-17	97.0	COG4447@1|root,COG4447@2|Bacteria,1MVIT@1224|Proteobacteria,1RZK1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
SRD2_k127_4148875_42	631454.N177_3653	2.041e-14	79.0	COG0251@1|root,COG0251@2|Bacteria,1RHMZ@1224|Proteobacteria,2U9H4@28211|Alphaproteobacteria,1JP4X@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	YjgF/chorismate_mutase-like, putative endoribonuclease	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
SRD2_k127_4148875_34	869210.Marky_0451	5.144e-42	163.0	COG0785@1|root,COG0785@2|Bacteria,1WJ3U@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	PFAM cytochrome c biogenesis protein, transmembrane region	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
SRD2_k127_4148875_40	864702.OsccyDRAFT_2212	4.417e-17	84.0	COG0425@1|root,COG0425@2|Bacteria,1G7QS@1117|Cyanobacteria,1HC2F@1150|Oscillatoriales	1117|Cyanobacteria	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	TusA
SRD2_k127_4148875_29	1121385.AQXW01000004_gene3286	1.805e-52	204.0	COG0642@1|root,COG2205@2|Bacteria,2GIV9@201174|Actinobacteria,1ZVG0@145357|Dermacoccaceae	201174|Actinobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	phoR	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
SRD2_k127_4148875_21	1173026.Glo7428_0934	2.494e-74	256.0	COG0745@1|root,COG0745@2|Bacteria	1173026.Glo7428_0934|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_4148875_13	1128421.JAGA01000001_gene2170	2.398e-116	387.0	COG3569@1|root,COG3569@2|Bacteria	2|Bacteria	L	DNA topoisomerase type I activity	topI	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_I
SRD2_k127_4148875_32	479434.Sthe_3289	1.696e-47	184.0	COG0671@1|root,COG0671@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
SRD2_k127_4148875_38	68170.KL590477_gene2093	4.405e-26	116.0	COG2085@1|root,COG2085@2|Bacteria,2GMZ5@201174|Actinobacteria,4E13X@85010|Pseudonocardiales	201174|Actinobacteria	S	NADP oxidoreductase coenzyme F420-dependent	npdG	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
SRD2_k127_4148875_24	986075.CathTA2_1195	2.771e-68	243.0	COG1250@1|root,COG1250@2|Bacteria,1TPA4@1239|Firmicutes,4HEAF@91061|Bacilli	91061|Bacilli	I	3-hydroxyacyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	3HCDH,3HCDH_N
SRD2_k127_4148875_36	479434.Sthe_1102	4.62e-37	146.0	COG0517@1|root,COG0517@2|Bacteria,2G8Z8@200795|Chloroflexi,27Z77@189775|Thermomicrobia	189775|Thermomicrobia	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SRD2_k127_4148875_45	324602.Caur_0944	3.747e-10	73.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_11,Lipase_GDSL,Lipase_GDSL_2,SASA
SRD2_k127_4148875_18	391625.PPSIR1_25986	3.049e-92	326.0	COG1866@1|root,COG1866@2|Bacteria	2|Bacteria	H	phosphoenolpyruvate carboxykinase (ATP) activity	pckA	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005488,GO:0005509,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0017076,GO:0019318,GO:0019319,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3169,iSB619.SA_RS09060,iSF_1195.SF3422,iUTI89_1310.UTI89_C3903,iYO844.BSU30560	PEPCK_ATP
SRD2_k127_4148875_16	644283.Micau_0677	8.326e-95	329.0	COG2301@1|root,COG2301@2|Bacteria,2GK5J@201174|Actinobacteria,4DC4N@85008|Micromonosporales	201174|Actinobacteria	G	Belongs to the HpcH HpaI aldolase family	mcl1	-	4.1.3.34,5.4.99.63	ko:K01644,ko:K14447	ko00630,ko01120,ko01200,ko02020,map00630,map01120,map01200,map02020	M00373	R00362,R09292	RC00067,RC01118,RC02835	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI
SRD2_k127_4148875_12	1122604.JONR01000020_gene499	6.629e-122	411.0	COG1073@1|root,COG1073@2|Bacteria,1R7FW@1224|Proteobacteria,1RYTX@1236|Gammaproteobacteria,1XA4H@135614|Xanthomonadales	135614|Xanthomonadales	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_4148875_26	485913.Krac_0576	2.451e-54	211.0	COG0451@1|root,COG0451@2|Bacteria,2G8UC@200795|Chloroflexi	200795|Chloroflexi	M	NmrA-like family	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
SRD2_k127_4148875_2	469383.Cwoe_4182	4.176e-166	532.0	COG0604@1|root,COG0604@2|Bacteria,2GKFF@201174|Actinobacteria,4CRE2@84995|Rubrobacteria	84995|Rubrobacteria	C	Zinc-binding dehydrogenase	-	-	1.3.1.85	ko:K14446	ko00630,ko01120,ko01200,map00630,map01120,map01200	M00373	R09291	RC02481	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
SRD2_k127_4148875_0	273068.TTE1217	2.674e-212	674.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,42FIA@68295|Thermoanaerobacterales	186801|Clostridia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01847,ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
SRD2_k127_4148875_47	326427.Cagg_0050	4.11e-05	52.0	COG1595@1|root,COG1595@2|Bacteria,2G6PJ@200795|Chloroflexi,375U9@32061|Chloroflexia	32061|Chloroflexia	K	PFAM sigma-70 region 2 domain protein	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SRD2_k127_4148875_33	561175.KB894097_gene346	3.576e-43	164.0	COG0177@1|root,COG0177@2|Bacteria,2GNE5@201174|Actinobacteria,4EINZ@85012|Streptosporangiales	201174|Actinobacteria	L	HhH-GPD superfamily base excision DNA repair protein	-	-	-	-	-	-	-	-	-	-	-	-	HhH-GPD
SRD2_k127_4148875_20	1122182.KB903834_gene5853	8.145e-77	261.0	COG2030@1|root,COG2030@2|Bacteria,2GN4R@201174|Actinobacteria,4D9AA@85008|Micromonosporales	201174|Actinobacteria	I	Maoc domain protein dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
SRD2_k127_4148875_4	1996.JOFO01000039_gene6489	2.276e-151	487.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4EHQC@85012|Streptosporangiales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SRD2_k127_4148875_35	309801.trd_0777	4.194e-37	144.0	COG0391@1|root,COG0391@2|Bacteria,2G5MJ@200795|Chloroflexi,27XU0@189775|Thermomicrobia	189775|Thermomicrobia	S	Required for morphogenesis under gluconeogenic growth conditions	-	-	-	-	-	-	-	-	-	-	-	-	UPF0052
SRD2_k127_4194588_0	247490.KSU1_D0321	6.322e-99	331.0	COG1005@1|root,COG1005@2|Bacteria,2IXH1@203682|Planctomycetes	203682|Planctomycetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
SRD2_k127_4194588_1	926550.CLDAP_08700	3.461e-48	180.0	COG1143@1|root,COG1143@2|Bacteria,2G6P8@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338,ko:K05580	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
SRD2_k127_4197222_1	1380347.JNII01000007_gene497	1.93e-17	93.0	2CBE1@1|root,32RT5@2|Bacteria,2IQDS@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_4197222_0	1121920.AUAU01000018_gene1775	2.161e-25	111.0	COG2318@1|root,COG2318@2|Bacteria,3Y4HW@57723|Acidobacteria	57723|Acidobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
SRD2_k127_4197222_2	1279009.ADICEAN_03629	0.0001216	51.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	-	-	1.23.1.1,1.23.1.2,1.23.1.3,1.23.1.4	ko:K21568	-	-	-	-	ko00000,ko01000	-	-	-	NAD_binding_10,NmrA
SRD2_k127_4202254_0	487521.OCU_33800	3.557e-132	426.0	COG4221@1|root,COG4221@2|Bacteria,2HA4H@201174|Actinobacteria,232MS@1762|Mycobacteriaceae	201174|Actinobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SRD2_k127_4202254_1	487521.OCU_33810	7.81e-100	334.0	COG1414@1|root,COG1414@2|Bacteria,2IC5N@201174|Actinobacteria,2337U@1762|Mycobacteriaceae	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR
SRD2_k127_4202254_2	862751.SACTE_6505	9.158e-46	177.0	COG2259@1|root,COG2259@2|Bacteria,2HD6Y@201174|Actinobacteria	201174|Actinobacteria	ADL	DoxX family	doxX	-	-	-	-	-	-	-	-	-	-	-	DoxX
SRD2_k127_4218602_1	525909.Afer_1115	4.276e-18	93.0	2BM3X@1|root,32FM8@2|Bacteria,2HH03@201174|Actinobacteria,4CP0F@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_4218602_0	1304872.JAGC01000009_gene817	1.668e-180	587.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJ0D@28221|Deltaproteobacteria,2M88M@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
SRD2_k127_4230893_26	1230342.CTM_21573	6.811e-05	55.0	2C7XN@1|root,32RK1@2|Bacteria,1VAMT@1239|Firmicutes,24X4C@186801|Clostridia,36P6G@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Abi
SRD2_k127_4230893_0	383372.Rcas_4052	0.0	1478.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,2G5M1@200795|Chloroflexi,376VN@32061|Chloroflexia	32061|Chloroflexia	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
SRD2_k127_4230893_3	525904.Tter_2069	7.109e-183	596.0	COG0531@1|root,COG0531@2|Bacteria,2NNZQ@2323|unclassified Bacteria	2|Bacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
SRD2_k127_4230893_8	1453496.AT03_06745	2.452e-60	220.0	COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,1RNY2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	response regulator	kdpE	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SRD2_k127_4230893_13	1238182.C882_1624	1.849e-39	162.0	COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2TR1M@28211|Alphaproteobacteria,2JQMA@204441|Rhodospirillales	204441|Rhodospirillales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,SSF
SRD2_k127_4230893_6	1380356.JNIK01000011_gene1691	1.427e-73	266.0	COG1075@1|root,COG1075@2|Bacteria,2IBAW@201174|Actinobacteria	201174|Actinobacteria	S	PGAP1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,DUF676,PGAP1
SRD2_k127_4230893_25	472759.Nhal_4001	1.466e-05	55.0	COG0551@1|root,COG1715@1|root,COG0551@2|Bacteria,COG1715@2|Bacteria,1QX0X@1224|Proteobacteria,1T3F3@1236|Gammaproteobacteria,1X0TG@135613|Chromatiales	135613|Chromatiales	V	DNA topoisomerase type IA zn finger domain protein	-	-	-	ko:K07448	-	-	-	-	ko00000,ko02048	-	-	-	Mrr_cat,zf-C4_Topoisom
SRD2_k127_4230893_7	367299.JOEE01000006_gene882	1.731e-60	238.0	COG5001@1|root,COG5001@2|Bacteria	2|Bacteria	T	cyclic-guanylate-specific phosphodiesterase activity	-	-	2.7.7.65	ko:K21023	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000	-	-	-	EAL,GGDEF,PAS,PAS_4
SRD2_k127_4230893_10	1380354.JIAN01000006_gene600	6.318e-48	187.0	COG2199@1|root,COG2200@1|root,COG2200@2|Bacteria,COG3706@2|Bacteria,2IIRA@201174|Actinobacteria	201174|Actinobacteria	T	PFAM EAL domain protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,PAS,PAS_3,Response_reg
SRD2_k127_4230893_17	1121011.AUCB01000005_gene2346	5.035e-21	109.0	COG3356@1|root,COG3356@2|Bacteria,4NH6U@976|Bacteroidetes,1I7V8@117743|Flavobacteriia,23GQ7@178469|Arenibacter	976|Bacteroidetes	S	PFAM Neutral alkaline nonlysosomal ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
SRD2_k127_4230893_21	525909.Afer_1115	1.731e-11	72.0	2BM3X@1|root,32FM8@2|Bacteria,2HH03@201174|Actinobacteria,4CP0F@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_4230893_5	1463858.JOHR01000001_gene6186	2.709e-120	411.0	COG2303@1|root,COG2303@2|Bacteria,2I5YA@201174|Actinobacteria	2|Bacteria	E	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C
SRD2_k127_4230893_24	240015.ACP_1357	7.738e-07	62.0	COG4447@1|root,COG4447@2|Bacteria,3Y46N@57723|Acidobacteria,2JMGI@204432|Acidobacteriia	204432|Acidobacteriia	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_4230893_19	644966.Tmar_1511	2.974e-17	95.0	2DBT9@1|root,32TY2@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07234	-	-	-	-	ko00000	-	-	-	-
SRD2_k127_4230893_27	1380390.JIAT01000010_gene3544	0.0003772	48.0	2A14K@1|root,30PAF@2|Bacteria,2HR2Y@201174|Actinobacteria,4CSY5@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_4230893_22	33876.JNXY01000020_gene4379	7.034e-11	70.0	COG1846@1|root,COG1846@2|Bacteria,2IQNM@201174|Actinobacteria,4DFM4@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
SRD2_k127_4230893_2	1382306.JNIM01000001_gene736	1.496e-183	606.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,2G83U@200795|Chloroflexi	200795|Chloroflexi	P	Voltage gated chloride channel	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Voltage_CLC
SRD2_k127_4230893_1	1229780.BN381_350020	1.319e-299	926.0	COG2041@1|root,COG4117@1|root,COG2041@2|Bacteria,COG4117@2|Bacteria,2GIZH@201174|Actinobacteria	201174|Actinobacteria	C	Oxidoreductase molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB,Oxidored_molyb
SRD2_k127_4230893_14	29306.JOBE01000001_gene2614	1.456e-35	152.0	COG3568@1|root,COG3568@2|Bacteria,2IGGC@201174|Actinobacteria	201174|Actinobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
SRD2_k127_4230893_4	1089544.KB912942_gene2376	1.125e-126	431.0	COG2936@1|root,COG2936@2|Bacteria,2I357@201174|Actinobacteria,4EE33@85010|Pseudonocardiales	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	PepX_C,Peptidase_S15
SRD2_k127_4230893_18	106370.Francci3_0743	5.619e-18	94.0	COG1309@1|root,COG1309@2|Bacteria,2IF6A@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
SRD2_k127_4230893_9	1298864.AUEQ01000010_gene3148	2.949e-57	212.0	COG0300@1|root,COG0300@2|Bacteria,2GMI7@201174|Actinobacteria,2389H@1762|Mycobacteriaceae	201174|Actinobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SRD2_k127_4230893_16	1057002.KB905370_gene2584	3.24e-30	128.0	COG2020@1|root,COG2020@2|Bacteria,1MZ7S@1224|Proteobacteria,2UBYC@28211|Alphaproteobacteria,4BC19@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
SRD2_k127_4230893_12	1463825.JNXC01000045_gene3035	3.356e-41	162.0	COG1733@1|root,COG1733@2|Bacteria,2GMK5@201174|Actinobacteria,4E53N@85010|Pseudonocardiales	201174|Actinobacteria	K	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,HxlR,SCP2
SRD2_k127_4230893_11	479434.Sthe_0116	2.161e-44	168.0	COG2146@1|root,COG4244@1|root,COG2146@2|Bacteria,COG4244@2|Bacteria	2|Bacteria	E	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231,Rieske
SRD2_k127_4231043_2	208439.AJAP_30445	3.675e-83	299.0	COG5276@1|root,COG5276@2|Bacteria,2HIIB@201174|Actinobacteria,4DY39@85010|Pseudonocardiales	201174|Actinobacteria	S	repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
SRD2_k127_4231043_1	1298863.AUEP01000001_gene785	3.268e-83	304.0	COG4585@1|root,COG4585@2|Bacteria,2GMMU@201174|Actinobacteria,4DV3H@85009|Propionibacteriales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
SRD2_k127_4231043_0	258533.BN977_03375	2.944e-85	309.0	COG4585@1|root,COG4585@2|Bacteria,2HDZV@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
SRD2_k127_4231043_3	221288.JH992901_gene1080	2.722e-06	53.0	COG0451@1|root,COG0451@2|Bacteria,1GEYX@1117|Cyanobacteria	1117|Cyanobacteria	GM	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
SRD2_k127_4258843_2	1382306.JNIM01000001_gene2738	6.491e-97	325.0	COG1960@1|root,COG1960@2|Bacteria,2G5K3@200795|Chloroflexi	200795|Chloroflexi	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SRD2_k127_4258843_3	1298864.AUEQ01000011_gene283	3.85e-10	70.0	COG0491@1|root,COG0491@2|Bacteria,2IBQ9@201174|Actinobacteria,232NH@1762|Mycobacteriaceae	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SRD2_k127_4258843_1	913865.DOT_3709	3.823e-116	397.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,260C1@186807|Peptococcaceae	186801|Clostridia	C	Acyl-CoA dehydrogenase, N-terminal	-	-	-	ko:K18244	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SRD2_k127_4258843_0	1408254.T458_05500	3.875e-123	405.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,4H9RJ@91061|Bacilli,26RP3@186822|Paenibacillaceae	91061|Bacilli	I	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation	mmgA	GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iYO844.BSU24170	Thiolase_C,Thiolase_N
SRD2_k127_4274450_0	204669.Acid345_2863	7.957e-73	249.0	COG3285@1|root,COG3285@2|Bacteria,3Y637@57723|Acidobacteria,2JM9H@204432|Acidobacteriia	204432|Acidobacteriia	L	dna ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	-
SRD2_k127_4274450_3	706434.HMPREF9429_01313	3.479e-29	133.0	COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,4H1XM@909932|Negativicutes	909932|Negativicutes	D	Peptidase M23	envC_1	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
SRD2_k127_4274450_1	479434.Sthe_1663	1.624e-43	176.0	COG3359@1|root,COG3359@2|Bacteria	2|Bacteria	L	RNase_H superfamily	yprB	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
SRD2_k127_4274450_2	997346.HMPREF9374_0253	7.686e-42	159.0	COG1205@1|root,COG1205@2|Bacteria,1TSPA@1239|Firmicutes,4H9T2@91061|Bacilli	91061|Bacilli	L	COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster	yprA	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
SRD2_k127_4311863_1	671143.DAMO_0317	2.812e-11	77.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	ASH,BNR_2,CBM_35,DUF1080,PKD
SRD2_k127_4311863_0	1137268.AZXF01000014_gene30	6.524e-45	181.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,4EMJ5@85012|Streptosporangiales	201174|Actinobacteria	U	Type II/IV secretion system protein	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
SRD2_k127_4311863_2	1042377.AFPJ01000052_gene1537	0.0001232	53.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,1RNB0@1236|Gammaproteobacteria,46617@72275|Alteromonadaceae	1236|Gammaproteobacteria	D	protein involved in exopolysaccharide biosynthesis	-	-	-	ko:K16554,ko:K16692	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,Wzz
SRD2_k127_4311863_3	1416759.AYMR01000008_gene2704	0.0003668	51.0	COG0745@1|root,COG0745@2|Bacteria,2GJ2N@201174|Actinobacteria,4FM5Q@85023|Microbacteriaceae	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	kdpE	-	-	ko:K02483,ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SRD2_k127_431199_0	483219.LILAB_17255	1.368e-53	206.0	COG3385@1|root,COG5659@1|root,COG3385@2|Bacteria,COG5659@2|Bacteria,1MXSV@1224|Proteobacteria,42UR2@68525|delta/epsilon subdivisions,2WQER@28221|Deltaproteobacteria,2YWHS@29|Myxococcales	28221|Deltaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
SRD2_k127_4317899_1	889378.Spiaf_1300	2.439e-32	139.0	COG2897@1|root,COG2897@2|Bacteria,2JB6F@203691|Spirochaetes	203691|Spirochaetes	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.11,2.8.1.2	ko:K01011,ko:K21028	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106,R07461	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
SRD2_k127_4317899_2	196490.AUEZ01000080_gene1978	0.0006075	50.0	COG0741@1|root,COG0741@2|Bacteria,1NWS6@1224|Proteobacteria,2USD1@28211|Alphaproteobacteria,3K48A@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
SRD2_k127_4323301_1	981369.JQMJ01000004_gene4710	2.597e-55	199.0	COG0346@1|root,COG0346@2|Bacteria,2IKNQ@201174|Actinobacteria	201174|Actinobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SRD2_k127_4323301_2	1278073.MYSTI_03341	7.279e-41	155.0	COG1917@1|root,COG1917@2|Bacteria,1RHHY@1224|Proteobacteria	1224|Proteobacteria	S	Cupin 2, conserved barrel	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,Cupin_3
SRD2_k127_4323301_3	1206744.BAGL01000042_gene1144	1.558e-20	106.0	COG1506@1|root,COG1506@2|Bacteria,2HHBX@201174|Actinobacteria,4FX9H@85025|Nocardiaceae	201174|Actinobacteria	E	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
SRD2_k127_4323301_0	1449048.JQKU01000019_gene4130	2.178e-114	378.0	COG0306@1|root,COG0306@2|Bacteria,2GJHK@201174|Actinobacteria,237YS@1762|Mycobacteriaceae	201174|Actinobacteria	P	Phosphate transporter family	pitB	GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	iNJ661.Rv2281	PHO4
SRD2_k127_4325727_1	292459.STH1996	1.157e-06	61.0	COG0517@1|root,COG0517@2|Bacteria,1V9ZB@1239|Firmicutes,25ESC@186801|Clostridia	186801|Clostridia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SRD2_k127_4325727_0	502025.Hoch_4802	1.11e-23	115.0	29HWC@1|root,304TF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
SRD2_k127_4326215_5	1123313.ATUT01000002_gene379	8.874e-19	94.0	COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,3VPC9@526524|Erysipelotrichia	526524|Erysipelotrichia	E	ABC transporter, substrate-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
SRD2_k127_4326215_0	383372.Rcas_1062	5.591e-135	440.0	COG4608@1|root,COG4608@2|Bacteria,2G5R5@200795|Chloroflexi,3750H@32061|Chloroflexia	32061|Chloroflexia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
SRD2_k127_4326215_1	292459.STH2824	2.533e-119	394.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
SRD2_k127_4326215_2	511051.CSE_11690	2.54e-71	258.0	COG1173@1|root,COG1173@2|Bacteria	2|Bacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	appC	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
SRD2_k127_4326215_3	1211817.CCAT010000045_gene2930	7.524e-71	250.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,36F10@31979|Clostridiaceae	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
SRD2_k127_4326215_4	189425.PGRAT_04545	2.833e-61	234.0	COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,4HARF@91061|Bacilli,26QIY@186822|Paenibacillaceae	91061|Bacilli	E	ABC transporter substrate-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
SRD2_k127_4343954_11	1128421.JAGA01000003_gene3515	1.723e-16	84.0	COG4911@1|root,COG4911@2|Bacteria,2NQ4H@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterized conserved protein (DUF2203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2203
SRD2_k127_4343954_12	1123065.ATWL01000028_gene1947	1.051e-14	79.0	COG0216@1|root,COG0216@2|Bacteria,2I7Z4@201174|Actinobacteria	201174|Actinobacteria	J	chain release factor	-	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
SRD2_k127_4343954_0	1123368.AUIS01000007_gene2717	8.536e-168	542.0	COG1164@1|root,COG1164@2|Bacteria,1MXAC@1224|Proteobacteria,1S6M5@1236|Gammaproteobacteria,2NBV4@225057|Acidithiobacillales	225057|Acidithiobacillales	E	Oligopeptidase F	-	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
SRD2_k127_4343954_10	886293.Sinac_4737	1.912e-20	93.0	COG1164@1|root,COG1164@2|Bacteria,2IWWZ@203682|Planctomycetes	203682|Planctomycetes	E	oligoendopeptidase F	-	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
SRD2_k127_4343954_2	1380390.JIAT01000007_gene5186	1.781e-89	306.0	COG2141@1|root,COG2141@2|Bacteria,2GIY3@201174|Actinobacteria,4CPP7@84995|Rubrobacteria	84995|Rubrobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
SRD2_k127_4343954_4	1283299.AUKG01000002_gene3648	4.695e-75	261.0	COG0789@1|root,COG0789@2|Bacteria,2GKAU@201174|Actinobacteria,4CRRD@84995|Rubrobacteria	84995|Rubrobacteria	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
SRD2_k127_4343954_7	561175.KB894096_gene397	1.429e-24	109.0	COG3255@1|root,COG3255@2|Bacteria,2GWVN@201174|Actinobacteria	201174|Actinobacteria	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
SRD2_k127_4343954_3	981369.JQMJ01000004_gene5751	6.294e-78	270.0	COG3662@1|root,COG3662@2|Bacteria,2GJD2@201174|Actinobacteria,2NHHS@228398|Streptacidiphilus	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2236)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2236
SRD2_k127_4343954_9	485913.Krac_7869	1.112e-21	109.0	COG4243@1|root,COG4243@2|Bacteria	2|Bacteria	S	quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4,VKOR
SRD2_k127_4343954_6	1382306.JNIM01000001_gene1733	1.622e-50	190.0	arCOG03842@1|root,30WW9@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF929)	-	-	-	-	-	-	-	-	-	-	-	-	DUF929
SRD2_k127_4343954_13	742742.HMPREF9452_00283	3.264e-13	80.0	COG0468@1|root,COG0468@2|Bacteria,2GJ4P@201174|Actinobacteria,4CUYM@84998|Coriobacteriia	84998|Coriobacteriia	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
SRD2_k127_4343954_8	1156937.MFUM_720005	4.372e-23	115.0	COG0389@1|root,COG0389@2|Bacteria,46SNK@74201|Verrucomicrobia,37GBB@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
SRD2_k127_4343954_14	479434.Sthe_2046	5.952e-06	54.0	29U2R@1|root,30FC1@2|Bacteria,2G9M3@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_4343954_1	882083.SacmaDRAFT_0798	5.692e-92	322.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4DYKC@85010|Pseudonocardiales	201174|Actinobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	GO:0000731,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0019985,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042276,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
SRD2_k127_4343954_5	1246995.AFR_01530	1.115e-70	248.0	COG3324@1|root,COG3324@2|Bacteria,2GJFC@201174|Actinobacteria,4D9V1@85008|Micromonosporales	201174|Actinobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
SRD2_k127_4357_0	644283.Micau_3864	5.727e-65	239.0	2DBGS@1|root,2Z95N@2|Bacteria,2ICPX@201174|Actinobacteria,4DAIQ@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_4357_1	512565.AMIS_32830	1.107e-36	140.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4DBTV@85008|Micromonosporales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
SRD2_k127_4358634_3	867903.ThesuDRAFT_01133	2.987e-25	108.0	COG0730@1|root,COG0730@2|Bacteria,1TPMA@1239|Firmicutes,25CI8@186801|Clostridia	186801|Clostridia	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
SRD2_k127_4358634_1	1155718.KB891854_gene3038	5.505e-103	342.0	COG0842@1|root,COG0842@2|Bacteria,2GN6S@201174|Actinobacteria	201174|Actinobacteria	V	transport, permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
SRD2_k127_4358634_0	1003195.SCAT_1089	5.269e-126	411.0	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	drrA_2	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SRD2_k127_4358634_2	1348663.KCH_56550	1.264e-31	124.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,2M302@2063|Kitasatospora	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SRD2_k127_440274_0	1246995.AFR_22625	1.406e-68	234.0	COG0842@1|root,COG0842@2|Bacteria,2GIVW@201174|Actinobacteria,4DAHH@85008|Micromonosporales	201174|Actinobacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
SRD2_k127_440274_1	1298863.AUEP01000010_gene4406	7.988e-15	85.0	COG0642@1|root,COG2197@1|root,COG2197@2|Bacteria,COG2205@2|Bacteria,2IB5N@201174|Actinobacteria,4DTB4@85009|Propionibacteriales	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
SRD2_k127_4462118_9	1380347.JNII01000006_gene1616	4.004e-23	104.0	2E39M@1|root,32Y96@2|Bacteria,2IITE@201174|Actinobacteria,4EW7J@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_4462118_5	1306174.JODP01000005_gene1423	1.288e-48	188.0	COG0322@1|root,COG0322@2|Bacteria,2IG93@201174|Actinobacteria	201174|Actinobacteria	L	GIY-YIG type nucleases (URI domain)	-	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG
SRD2_k127_4462118_0	1380390.JIAT01000010_gene3879	0.0	1300.0	COG3957@1|root,COG3957@2|Bacteria,2GN27@201174|Actinobacteria,4CSGY@84995|Rubrobacteria	84995|Rubrobacteria	G	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase	-	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
SRD2_k127_4462118_1	1179773.BN6_38060	4.38e-110	369.0	COG0282@1|root,COG0282@2|Bacteria,2GJAW@201174|Actinobacteria,4DYVV@85010|Pseudonocardiales	201174|Actinobacteria	C	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
SRD2_k127_4462118_7	909663.KI867150_gene2841	5.403e-34	136.0	COG0662@1|root,COG0662@2|Bacteria,1RJ7D@1224|Proteobacteria,431RV@68525|delta/epsilon subdivisions,2WWFG@28221|Deltaproteobacteria,2MS3I@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SRD2_k127_4462118_11	1173021.ALWA01000008_gene1517	1.185e-10	69.0	COG4454@1|root,COG4454@2|Bacteria,1G83X@1117|Cyanobacteria	1117|Cyanobacteria	P	Sulfocyanin (SoxE) domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1,SoxE
SRD2_k127_4462118_13	1173021.ALWA01000008_gene1517	1.023e-09	70.0	COG4454@1|root,COG4454@2|Bacteria,1G83X@1117|Cyanobacteria	1117|Cyanobacteria	P	Sulfocyanin (SoxE) domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1,SoxE
SRD2_k127_4462118_4	867903.ThesuDRAFT_01256	3.44e-58	206.0	COG0400@1|root,COG0400@2|Bacteria,1VZ3H@1239|Firmicutes	1239|Firmicutes	S	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_4462118_8	1101188.KI912156_gene3809	1.028e-23	107.0	COG4315@1|root,COG4315@2|Bacteria,2GNDV@201174|Actinobacteria	201174|Actinobacteria	S	Secreted repeat of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	Lipoprotein_15
SRD2_k127_4462118_3	876269.ARWA01000001_gene33	7.687e-71	252.0	COG0526@1|root,COG0785@1|root,COG0526@2|Bacteria,COG0785@2|Bacteria,1MVV0@1224|Proteobacteria,2TS0V@28211|Alphaproteobacteria,3NAP7@45404|Beijerinckiaceae	28211|Alphaproteobacteria	CO	Cytochrome C biogenesis protein transmembrane region	dipZ	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DsbD,Redoxin
SRD2_k127_4462118_6	1502724.FF80_01473	4.018e-40	160.0	COG0785@1|root,COG0785@2|Bacteria,1RCP7@1224|Proteobacteria,2TSAI@28211|Alphaproteobacteria,3N6UN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	cytochrome c biogenesis protein	MA20_17170	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
SRD2_k127_4462118_10	279238.Saro_0604	7.318e-16	91.0	COG3391@1|root,COG3391@2|Bacteria,1R53R@1224|Proteobacteria,2U1FC@28211|Alphaproteobacteria,2K0VC@204457|Sphingomonadales	204457|Sphingomonadales	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_4462118_2	749414.SBI_09505	1.914e-82	281.0	COG0300@1|root,COG0300@2|Bacteria,2GKJE@201174|Actinobacteria	201174|Actinobacteria	P	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
SRD2_k127_4462118_12	1688.BCUN_0126	2.599e-10	63.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4CYUQ@85004|Bifidobacteriales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SRD2_k127_4488352_1	1120973.AQXL01000133_gene1770	3.013e-59	224.0	COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,1UVX8@1239|Firmicutes,4I2Q1@91061|Bacilli,2790H@186823|Alicyclobacillaceae	91061|Bacilli	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
SRD2_k127_4488352_0	324602.Caur_0934	2.154e-65	238.0	COG0410@1|root,COG0410@2|Bacteria,2G69M@200795|Chloroflexi,374YI@32061|Chloroflexia	32061|Chloroflexia	E	PFAM ABC transporter related	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
SRD2_k127_4537356_1	1210884.HG799469_gene14206	3.407e-46	181.0	COG2433@1|root,COG2433@2|Bacteria,2IYQC@203682|Planctomycetes	203682|Planctomycetes	S	Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
SRD2_k127_4537356_0	420324.KI911994_gene8036	1.643e-167	541.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria	1224|Proteobacteria	L	Resolvase	-	-	-	ko:K06400	-	-	-	-	ko00000	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
SRD2_k127_4540729_2	76114.ebA1943	1.003e-42	162.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2VJ2W@28216|Betaproteobacteria,2KY8S@206389|Rhodocyclales	28216|Betaproteobacteria	S	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
SRD2_k127_4540729_0	269482.Bcep1808_6250	5.804e-101	345.0	COG3293@1|root,COG3293@2|Bacteria,1REUV@1224|Proteobacteria,2VREC@28216|Betaproteobacteria,1K6P0@119060|Burkholderiaceae	28216|Betaproteobacteria	L	transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4096
SRD2_k127_4540729_3	224911.27350169	8.182e-13	74.0	COG5659@1|root,COG5659@2|Bacteria,1MXSV@1224|Proteobacteria,2TRKD@28211|Alphaproteobacteria,3K0HM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
SRD2_k127_4540729_1	1121022.ABENE_04845	1.176e-43	169.0	COG5659@1|root,COG5659@2|Bacteria,1MXSV@1224|Proteobacteria,2TRKD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
SRD2_k127_4547214_1	443143.GM18_2767	3.31e-86	292.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,42NG2@68525|delta/epsilon subdivisions,2WK33@28221|Deltaproteobacteria,43V8D@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
SRD2_k127_4547214_0	879212.DespoDRAFT_02827	2.392e-168	544.0	COG4584@1|root,COG4584@2|Bacteria,1MW5J@1224|Proteobacteria,42X93@68525|delta/epsilon subdivisions,2WSXR@28221|Deltaproteobacteria,2MQ06@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
SRD2_k127_4547214_2	46234.ANA_C20071	0.0003504	44.0	COG1715@1|root,COG1715@2|Bacteria	2|Bacteria	V	Restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DUF3644,Mrr_cat
SRD2_k127_4582749_5	324602.Caur_3763	4.916e-30	127.0	COG1216@1|root,COG1216@2|Bacteria,2G7UG@200795|Chloroflexi,3764Q@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
SRD2_k127_4582749_7	110319.CF8_1483	0.0002569	55.0	COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria,4DPUK@85009|Propionibacteriales	201174|Actinobacteria	Q	Multicopper oxidase	cotA	-	1.16.3.3	ko:K06324	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
SRD2_k127_4582749_3	1206720.BAFQ01000102_gene2559	1.786e-46	194.0	COG1520@1|root,COG1520@2|Bacteria,2IAZ2@201174|Actinobacteria,4FZ09@85025|Nocardiaceae	201174|Actinobacteria	S	PQQ enzyme repeat	-	-	1.1.2.6,2.7.11.1	ko:K05889,ko:K12132	-	-	R03136	-	ko00000,ko01000,ko01001	-	-	-	PQQ,PQQ_2,PQQ_3,Pkinase
SRD2_k127_4582749_1	1380390.JIAT01000015_gene5822	7.493e-86	321.0	COG3794@1|root,COG3794@2|Bacteria,2HQ6D@201174|Actinobacteria,4CRPC@84995|Rubrobacteria	84995|Rubrobacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_4582749_4	525904.Tter_0233	4.848e-39	160.0	COG2227@1|root,COG2227@2|Bacteria,2NQ8I@2323|unclassified Bacteria	2|Bacteria	H	Methyltransferase domain	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
SRD2_k127_4582749_2	584708.Apau_0249	8.5e-76	275.0	COG1232@1|root,COG1232@2|Bacteria,3TBWH@508458|Synergistetes	508458|Synergistetes	H	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
SRD2_k127_4582749_0	321327.CYA_1684	1.111e-122	399.0	COG3119@1|root,COG3119@2|Bacteria,1G15J@1117|Cyanobacteria,1H0BN@1129|Synechococcus	1117|Cyanobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
SRD2_k127_4582749_6	694430.Natoc_2251	1.867e-17	94.0	COG3119@1|root,arCOG02785@2157|Archaea,2Y8G5@28890|Euryarchaeota,241AK@183963|Halobacteria	183963|Halobacteria	P	COG3119 Arylsulfatase A and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
SRD2_k127_4615948_3	1183438.GKIL_2340	4.332e-50	192.0	COG1376@1|root,COG1376@2|Bacteria,1G4ZS@1117|Cyanobacteria	1117|Cyanobacteria	S	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
SRD2_k127_4615948_7	1192124.LIG30_3220	2.593e-08	66.0	2CIPC@1|root,2Z9HB@2|Bacteria,1R3W8@1224|Proteobacteria,2W2EE@28216|Betaproteobacteria,1K6UY@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
SRD2_k127_4615948_1	1173029.JH980292_gene300	2.463e-100	347.0	2DV73@1|root,33UF8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_4615948_5	643562.Daes_3264	1.52e-20	100.0	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,42PVX@68525|delta/epsilon subdivisions,2WIJ8@28221|Deltaproteobacteria,2M82Q@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	TIGRFAM Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF
SRD2_k127_4615948_2	926569.ANT_09920	3.26e-61	220.0	COG1131@1|root,COG1131@2|Bacteria,2G890@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SRD2_k127_4615948_4	1128421.JAGA01000002_gene13	4.474e-46	186.0	COG1300@1|root,COG1668@1|root,COG1300@2|Bacteria,COG1668@2|Bacteria	2|Bacteria	CP	transmembrane transport	-	-	-	ko:K01992,ko:K09696	ko02010,ko02020,map02010,map02020	M00253,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.115	-	-	ABC2_membrane,ABC2_membrane_2,ABC2_membrane_3,SpoIIM
SRD2_k127_4615948_6	1150399.AQYK01000001_gene845	3.712e-16	83.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4FKPR@85023|Microbacteriaceae	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
SRD2_k127_4615948_0	196367.JNFG01000013_gene5152	5.371e-219	710.0	COG1615@1|root,COG1615@2|Bacteria,1MZ5A@1224|Proteobacteria,2W1FV@28216|Betaproteobacteria,1K502@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Uncharacterised protein family (UPF0182)	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
SRD2_k127_4659217_2	314230.DSM3645_28077	5.192e-15	75.0	COG5340@1|root,COG5340@2|Bacteria,2J1R0@203682|Planctomycetes	203682|Planctomycetes	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_4659217_1	314230.DSM3645_28082	3.581e-40	154.0	COG2253@1|root,COG2253@2|Bacteria,2J2AA@203682|Planctomycetes	203682|Planctomycetes	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
SRD2_k127_4659217_0	365044.Pnap_1744	1.737e-51	196.0	COG5659@1|root,COG5659@2|Bacteria,1MXSV@1224|Proteobacteria,2VPGV@28216|Betaproteobacteria,4AD6V@80864|Comamonadaceae	28216|Betaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
SRD2_k127_4659770_1	526225.Gobs_1520	1.741e-19	102.0	COG2203@1|root,COG3852@1|root,COG5002@1|root,COG2203@2|Bacteria,COG3852@2|Bacteria,COG5002@2|Bacteria,2I337@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
SRD2_k127_4659770_0	1157637.KB892110_gene4255	6.056e-66	244.0	COG3447@1|root,COG3447@2|Bacteria,2GJB0@201174|Actinobacteria	201174|Actinobacteria	T	MASE1	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2,MASE1,SpoIIE
SRD2_k127_4659770_2	1123024.AUII01000020_gene3188	1.923e-05	55.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4DXHB@85010|Pseudonocardiales	201174|Actinobacteria	T	response regulator	mprA	GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009268,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010446,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0023052,GO:0030312,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0035556,GO:0043254,GO:0044087,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0090034,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141	-	ko:K07669,ko:K07672	ko02020,map02020	M00460,M00463	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SRD2_k127_466352_1	592028.GCWU000321_00178	1.7e-26	122.0	COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,4H1XM@909932|Negativicutes	909932|Negativicutes	D	Peptidase M23	envC_1	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
SRD2_k127_466352_0	935948.KE386494_gene410	4.227e-39	157.0	COG2177@1|root,COG2177@2|Bacteria,1TPND@1239|Firmicutes,24AA6@186801|Clostridia,42FMA@68295|Thermoanaerobacterales	186801|Clostridia	D	Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
SRD2_k127_466352_2	1122217.KB899570_gene994	9.721e-12	65.0	COG2884@1|root,COG2884@2|Bacteria,1TP58@1239|Firmicutes,4H22M@909932|Negativicutes	909932|Negativicutes	D	cell division ATP-binding protein FtsE	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
SRD2_k127_4703855_32	660470.Theba_1794	4.716e-08	54.0	arCOG06481@1|root,2ZB4E@2|Bacteria,2GE2H@200918|Thermotogae	200918|Thermotogae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_4703855_31	93220.LV28_06690	7.306e-18	91.0	COG3832@1|root,COG3832@2|Bacteria,1RICZ@1224|Proteobacteria,2VTB3@28216|Betaproteobacteria,1K597@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc,Polyketide_cyc2
SRD2_k127_4703855_22	1382356.JQMP01000003_gene1667	6.063e-48	184.0	COG2141@1|root,COG2141@2|Bacteria,2GB9A@200795|Chloroflexi,27Y8J@189775|Thermomicrobia	189775|Thermomicrobia	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
SRD2_k127_4703855_1	644966.Tmar_0009	1.279e-153	497.0	COG0172@1|root,COG0172@2|Bacteria,1TP4W@1239|Firmicutes,2485M@186801|Clostridia,3WCCW@538999|Clostridiales incertae sedis	186801|Clostridia	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
SRD2_k127_4703855_0	429009.Adeg_1647	2.289e-157	511.0	COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,247VX@186801|Clostridia,42EMJ@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon,tRNA_bind
SRD2_k127_4703855_24	696369.KI912183_gene2393	1.291e-41	158.0	COG0782@1|root,COG0782@2|Bacteria,1V44S@1239|Firmicutes,24HP9@186801|Clostridia,261HN@186807|Peptococcaceae	186801|Clostridia	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
SRD2_k127_4703855_12	1382304.JNIL01000001_gene1021	3.613e-82	286.0	COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,4HA9K@91061|Bacilli,279D3@186823|Alicyclobacillaceae	91061|Bacilli	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
SRD2_k127_4703855_30	1185876.BN8_04576	8.998e-22	102.0	COG1510@1|root,COG1510@2|Bacteria,4NQPD@976|Bacteroidetes,47PNM@768503|Cytophagia	976|Bacteroidetes	K	Belongs to the GbsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5,MarR_2,TrmB
SRD2_k127_4703855_16	485913.Krac_6709	1.044e-72	258.0	COG0702@1|root,COG0702@2|Bacteria,2G6I7@200795|Chloroflexi	200795|Chloroflexi	M	NmrA-like family	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	NAD_binding_10
SRD2_k127_4703855_28	748280.NH8B_3990	2.194e-24	108.0	COG0745@1|root,COG0745@2|Bacteria,1RHCU@1224|Proteobacteria,2VT7U@28216|Betaproteobacteria,2KTJ0@206351|Neisseriales	206351|Neisseriales	KT	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
SRD2_k127_4703855_2	338963.Pcar_2565	7.359e-153	510.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WUAW@28221|Deltaproteobacteria,43U3F@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3,Response_reg
SRD2_k127_4703855_18	1173026.Glo7428_2204	6.765e-59	207.0	COG0784@1|root,COG0784@2|Bacteria,1GQ4W@1117|Cyanobacteria	1117|Cyanobacteria	T	PFAM response regulator receiveR	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
SRD2_k127_4703855_13	1123508.JH636449_gene7420	1.382e-81	294.0	COG2202@1|root,COG4191@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,COG4251@2|Bacteria,2IZ70@203682|Planctomycetes	203682|Planctomycetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9
SRD2_k127_4703855_11	264732.Moth_0146	1.022e-84	293.0	COG1521@1|root,COG1521@2|Bacteria,1TR0X@1239|Firmicutes,248PX@186801|Clostridia,42FD2@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
SRD2_k127_4703855_4	264732.Moth_2284	3.489e-135	449.0	COG0165@1|root,COG0165@2|Bacteria,1TNZ6@1239|Firmicutes,2489H@186801|Clostridia,42F08@68295|Thermoanaerobacterales	186801|Clostridia	E	TIGRFAM argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
SRD2_k127_4703855_3	552811.Dehly_0932	6.221e-152	497.0	COG0137@1|root,COG0137@2|Bacteria,2G5ME@200795|Chloroflexi,34CSW@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
SRD2_k127_4703855_29	264732.Moth_1508	2.391e-23	114.0	COG1438@1|root,COG1438@2|Bacteria,1V1R7@1239|Firmicutes,24HGQ@186801|Clostridia,42GDW@68295|Thermoanaerobacterales	186801|Clostridia	K	Regulates arginine biosynthesis genes	argR	-	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
SRD2_k127_4703855_5	1382306.JNIM01000001_gene1176	4.673e-133	438.0	COG4992@1|root,COG4992@2|Bacteria,2G5TW@200795|Chloroflexi	200795|Chloroflexi	E	TIGRFAM acetylornithine and succinylornithine aminotransferase	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SRD2_k127_4703855_9	1158318.ATXC01000001_gene1157	1.251e-92	314.0	COG0548@1|root,COG0548@2|Bacteria,2G3SD@200783|Aquificae	200783|Aquificae	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
SRD2_k127_4703855_6	1121468.AUBR01000019_gene2617	2.446e-115	385.0	COG1364@1|root,COG1364@2|Bacteria,1TPBP@1239|Firmicutes,2497Q@186801|Clostridia,42F14@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
SRD2_k127_4703855_10	485913.Krac_9970	5.539e-89	304.0	COG0002@1|root,COG0002@2|Bacteria,2G6D0@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
SRD2_k127_4703855_27	511051.CSE_05140	1.899e-24	113.0	COG0671@1|root,COG0671@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	PAP2,PAP2_3
SRD2_k127_4703855_26	1537715.JQFJ01000002_gene477	5.23e-30	133.0	COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,2UCKH@28211|Alphaproteobacteria,2K56R@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19	ko:K01496	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04037	RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH
SRD2_k127_4703855_8	697281.Mahau_0269	6.032e-95	333.0	COG0107@1|root,COG0107@2|Bacteria,1TP0W@1239|Firmicutes,24900@186801|Clostridia,42FAR@68295|Thermoanaerobacterales	186801|Clostridia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
SRD2_k127_4703855_20	370438.PTH_2535	4.651e-55	206.0	COG0118@1|root,COG0118@2|Bacteria,1TQT0@1239|Firmicutes,248SH@186801|Clostridia,260M0@186807|Peptococcaceae	186801|Clostridia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
SRD2_k127_4703855_21	754477.Q7C_1985	2.515e-52	193.0	COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,1RPA9@1236|Gammaproteobacteria,45ZPZ@72273|Thiotrichales	72273|Thiotrichales	E	imidazoleglycerol-phosphate dehydratase	hisB	-	3.1.3.15,4.2.1.19	ko:K01089,ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013,R03457	RC00017,RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD,PNK3P
SRD2_k127_4703855_7	429009.Adeg_0313	2.307e-105	369.0	COG0141@1|root,COG0141@2|Bacteria,1TPAW@1239|Firmicutes,248X8@186801|Clostridia,42EK0@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23,1.1.1.308	ko:K00013,ko:K15509	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
SRD2_k127_4703855_23	671143.DAMO_2246	6.477e-43	167.0	COG0040@1|root,COG0040@2|Bacteria,2NPCD@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG
SRD2_k127_4703855_14	498761.HM1_3053	3.556e-77	276.0	COG0124@1|root,COG0124@2|Bacteria,1UIUT@1239|Firmicutes,25ESP@186801|Clostridia	186801|Clostridia	J	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
SRD2_k127_4703855_19	1434929.X946_1573	2.029e-57	208.0	COG4122@1|root,COG4122@2|Bacteria,1QWQR@1224|Proteobacteria,2WCZZ@28216|Betaproteobacteria,1K8W1@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
SRD2_k127_4703855_15	1173026.Glo7428_2690	1.402e-74	259.0	COG1028@1|root,COG1028@2|Bacteria,1G67A@1117|Cyanobacteria	1117|Cyanobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SRD2_k127_4703855_25	383372.Rcas_3238	1.348e-37	153.0	COG0457@1|root,COG0457@2|Bacteria,2G6Q2@200795|Chloroflexi,375HW@32061|Chloroflexia	32061|Chloroflexia	S	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2
SRD2_k127_4703855_17	485913.Krac_9801	1.926e-69	259.0	COG0683@1|root,COG0683@2|Bacteria,2G6Q3@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
SRD2_k127_4729585_2	1408418.JNJH01000033_gene904	0.0002835	49.0	COG3391@1|root,COG3391@2|Bacteria,1R6BZ@1224|Proteobacteria,2U2WX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
SRD2_k127_4729585_0	891968.Anamo_0432	2.086e-75	264.0	COG0568@1|root,COG0568@2|Bacteria,3TACS@508458|Synergistetes	508458|Synergistetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
SRD2_k127_4729585_1	591158.SSMG_02380	6.563e-05	53.0	COG3794@1|root,COG3794@2|Bacteria,2H73G@201174|Actinobacteria	201174|Actinobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
SRD2_k127_4791196_1	997346.HMPREF9374_2495	1.016e-12	76.0	COG0204@1|root,COG0204@2|Bacteria,1U8N2@1239|Firmicutes,4HIJN@91061|Bacilli,27D2B@186824|Thermoactinomycetaceae	91061|Bacilli	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
SRD2_k127_4791196_0	1313172.YM304_17360	1.524e-16	84.0	COG2905@1|root,COG2905@2|Bacteria	2|Bacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	ko:K03281,ko:K08714,ko:K16922	-	-	-	-	ko00000,ko01002,ko02000	1.A.1.14,2.A.49	-	-	CBS,Ion_trans,NTP_transferase,TIR-like,cNMP_binding
SRD2_k127_4834425_7	316067.Geob_0122	1.573e-07	61.0	COG2010@1|root,COG2010@2|Bacteria,1RJJ2@1224|Proteobacteria,42SCM@68525|delta/epsilon subdivisions,2WPS4@28221|Deltaproteobacteria,43U4I@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Cytochrome c	pcmF	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
SRD2_k127_4834425_4	1382306.JNIM01000001_gene1048	1.717e-37	149.0	COG1290@1|root,COG1290@2|Bacteria	2|Bacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	pcmD	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C,Cytochrome_B
SRD2_k127_4834425_0	485913.Krac_6667	5.851e-87	293.0	COG1290@1|root,COG1290@2|Bacteria,2G8QQ@200795|Chloroflexi	200795|Chloroflexi	C	Cytochrome b(N-terminal)/b6/petB	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_B
SRD2_k127_4834425_3	1131269.AQVV01000039_gene1545	1.676e-39	153.0	COG0723@1|root,COG0723@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on diphenols and related substances as donors	-	-	1.10.9.1	ko:K02636,ko:K03886	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00151,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Rieske
SRD2_k127_4834425_6	485913.Krac_5132	1.325e-25	122.0	COG1376@1|root,COG1376@2|Bacteria,2G6ZY@200795|Chloroflexi	200795|Chloroflexi	M	PFAM ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	LysM,YkuD
SRD2_k127_4834425_5	671143.DAMO_3098	2.877e-29	122.0	COG2331@1|root,COG2331@2|Bacteria,2NRJX@2323|unclassified Bacteria	2|Bacteria	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
SRD2_k127_4834425_1	330214.NIDE3081	9.168e-74	254.0	COG3253@1|root,COG3253@2|Bacteria	2|Bacteria	S	peroxidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
SRD2_k127_4834425_2	1118054.CAGW01000053_gene1509	8.67e-53	194.0	COG1024@1|root,COG1024@2|Bacteria,1TQ2V@1239|Firmicutes,4HBT0@91061|Bacilli,26UEW@186822|Paenibacillaceae	91061|Bacilli	I	Belongs to the enoyl-CoA hydratase isomerase family	paaG	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
SRD2_k127_4858115_0	215803.DB30_1747	6.415e-33	147.0	COG5276@1|root,COG5276@2|Bacteria	2|Bacteria	-	-	MA20_04930	-	-	-	-	-	-	-	-	-	-	-	LVIVD
SRD2_k127_4893555_3	518766.Rmar_0313	1.785e-11	68.0	COG0711@1|root,COG0711@2|Bacteria,4NQKA@976|Bacteroidetes,1FJDB@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	ATP synthase F(0) sector subunit b	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
SRD2_k127_4893555_2	322710.Avin_52190	5.373e-22	106.0	COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iSF_1195.SF3815,iSFxv_1172.SFxv_4157,iS_1188.S3953	OSCP
SRD2_k127_4893555_0	525904.Tter_0065	1.231e-214	680.0	COG0056@1|root,COG0056@2|Bacteria,2NP0S@2323|unclassified Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	iIT341.HP1134,iSB619.SA_RS10975,iSbBS512_1146.SbBS512_E4187	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
SRD2_k127_4893555_1	768704.Desmer_4557	1.007e-69	246.0	COG0224@1|root,COG0224@2|Bacteria,1TPBX@1239|Firmicutes,2486Q@186801|Clostridia,2601T@186807|Peptococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
SRD2_k127_4955554_3	986075.CathTA2_0425	3.164e-60	217.0	COG0154@1|root,COG0154@2|Bacteria,1TPGJ@1239|Firmicutes,4HBE7@91061|Bacilli	91061|Bacilli	J	Belongs to the amidase family	-	-	3.5.1.4,6.3.5.6,6.3.5.7	ko:K01426,ko:K02433	ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120	-	R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
SRD2_k127_4955554_2	1278073.MYSTI_03501	4.015e-82	287.0	COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,42P5X@68525|delta/epsilon subdivisions,2WIQW@28221|Deltaproteobacteria,2YU6V@29|Myxococcales	28221|Deltaproteobacteria	E	Methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
SRD2_k127_4955554_9	448385.sce8495	1.169e-12	72.0	COG0642@1|root,COG0745@1|root,COG2203@1|root,COG2461@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG2461@2|Bacteria,1NRP8@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PocR,Response_reg
SRD2_k127_4955554_0	479434.Sthe_1831	2.598e-112	386.0	COG0154@1|root,COG0154@2|Bacteria	2|Bacteria	J	amidase activity	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
SRD2_k127_4955554_4	1382306.JNIM01000001_gene3877	5.172e-60	218.0	COG0682@1|root,COG0682@2|Bacteria,2G78M@200795|Chloroflexi	200795|Chloroflexi	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
SRD2_k127_4955554_8	460265.Mnod_6765	1.026e-46	180.0	COG0697@1|root,COG0697@2|Bacteria,1MZQM@1224|Proteobacteria,2TUPG@28211|Alphaproteobacteria,1JSVX@119045|Methylobacteriaceae	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SRD2_k127_4955554_1	28444.JODQ01000015_gene1696	2.032e-100	338.0	COG1125@1|root,COG1125@2|Bacteria,2GJHI@201174|Actinobacteria,4EH2R@85012|Streptosporangiales	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran
SRD2_k127_4955554_6	1089545.KB913037_gene1256	2.894e-56	209.0	COG1732@1|root,COG1732@2|Bacteria,2GJWY@201174|Actinobacteria,4DZK6@85010|Pseudonocardiales	201174|Actinobacteria	M	Substrate binding domain of ABC-type glycine betaine transport system	-	-	-	ko:K05845	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
SRD2_k127_4955554_5	1122139.KB907877_gene3015	8.451e-60	222.0	COG1174@1|root,COG1174@2|Bacteria,1MXA1@1224|Proteobacteria,1RQ1F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	transport	-	-	-	ko:K05845,ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1,OpuAC
SRD2_k127_4955554_7	1089552.KI911559_gene1300	3.233e-56	201.0	COG1174@1|root,COG1174@2|Bacteria,1MXA1@1224|Proteobacteria,2TUNH@28211|Alphaproteobacteria,2JRQ5@204441|Rhodospirillales	204441|Rhodospirillales	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
SRD2_k127_497846_9	1120972.AUMH01000007_gene1671	3.931e-28	124.0	COG0771@1|root,COG0771@2|Bacteria,1TQ3P@1239|Firmicutes,4HA5P@91061|Bacilli,2785Y@186823|Alicyclobacillaceae	91061|Bacilli	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
SRD2_k127_497846_16	670487.Ocepr_1783	3.917e-06	58.0	2EC2Y@1|root,3361X@2|Bacteria,1WKKQ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	TIGRFAM Lysine biosynthesis protein LysW	lysW	-	-	ko:K05826	-	M00031,M00763	-	-	ko00000,ko00001,ko00002	-	-	-	TF_Zn_Ribbon
SRD2_k127_497846_15	568706.BN118_2634	1.216e-08	67.0	COG0498@1|root,COG0498@2|Bacteria,1R7X1@1224|Proteobacteria,2VHX3@28216|Betaproteobacteria,3T6FQ@506|Alcaligenaceae	28216|Betaproteobacteria	E	Threonine synthase	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SRD2_k127_497846_13	665577.JH993790_gene5700	2.371e-18	98.0	COG0439@1|root,COG0439@2|Bacteria,2HTQR@201174|Actinobacteria	201174|Actinobacteria	I	Biotin carboxylase-like protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_497846_17	1500897.JQNA01000002_gene3816	5.509e-05	55.0	COG4963@1|root,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,2VNYQ@28216|Betaproteobacteria,1K0IB@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Pilus assembly protein	cpaE1	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31
SRD2_k127_497846_8	110319.CF8_1260	2.016e-44	166.0	COG1451@1|root,COG1451@2|Bacteria,2GMP6@201174|Actinobacteria,4DQV0@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
SRD2_k127_497846_3	525904.Tter_1098	1.283e-81	277.0	COG0745@1|root,COG0745@2|Bacteria,2NQA9@2323|unclassified Bacteria	2|Bacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
SRD2_k127_497846_2	35754.JNYJ01000022_gene8131	4.963e-98	338.0	COG5002@1|root,COG5002@2|Bacteria,2I2DU@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
SRD2_k127_497846_10	675635.Psed_4504	1.395e-27	129.0	COG0845@1|root,COG0845@2|Bacteria,2H154@201174|Actinobacteria,4DZ36@85010|Pseudonocardiales	201174|Actinobacteria	M	HlyD family secretion protein	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
SRD2_k127_497846_4	1123023.JIAI01000033_gene4179	3.268e-77	267.0	COG1136@1|root,COG1136@2|Bacteria,2GK3I@201174|Actinobacteria,4DXK6@85010|Pseudonocardiales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SRD2_k127_497846_1	1449976.KALB_8336	6.665e-112	378.0	COG0577@1|root,COG0577@2|Bacteria,2GIRW@201174|Actinobacteria,4E178@85010|Pseudonocardiales	201174|Actinobacteria	V	MacB-like periplasmic core domain	yknZ	-	-	ko:K02004,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	FtsX,MacB_PCD
SRD2_k127_497846_14	1449976.KALB_8335	3.991e-18	94.0	2CKHU@1|root,334YX@2|Bacteria,2IPK0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_497846_6	886293.Sinac_7544	5.888e-70	263.0	COG0784@1|root,COG2198@1|root,COG2202@1|root,COG2203@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG5002@2|Bacteria,2J4YH@203682|Planctomycetes	203682|Planctomycetes	T	His Kinase A (phosphoacceptor	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS_4,Response_reg
SRD2_k127_497846_11	926569.ANT_11850	1.619e-22	104.0	COG0784@1|root,COG0784@2|Bacteria,2GBNB@200795|Chloroflexi	200795|Chloroflexi	T	cheY-homologous receiver domain	-	-	-	ko:K11443	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
SRD2_k127_497846_12	1405498.SSIM_05990	1.232e-19	101.0	COG1388@1|root,COG3942@1|root,COG1388@2|Bacteria,COG3942@2|Bacteria,1V8WM@1239|Firmicutes,4I27S@91061|Bacilli,4GX44@90964|Staphylococcaceae	91061|Bacilli	M	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	CHAP,LysM
SRD2_k127_497846_0	1150864.MILUP08_41959	2.139e-159	526.0	COG3408@1|root,COG3408@2|Bacteria,2GIUI@201174|Actinobacteria	201174|Actinobacteria	G	Amylo-alpha-1,6-glucosidase	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N_bis
SRD2_k127_497846_5	2002.JOEQ01000012_gene5732	2.81e-71	254.0	COG0438@1|root,COG0438@2|Bacteria,2I005@201174|Actinobacteria,4EJVU@85012|Streptosporangiales	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SRD2_k127_500657_2	1131462.DCF50_p421	0.0001525	47.0	2EHWQ@1|root,33BNA@2|Bacteria,1VNEI@1239|Firmicutes,24WX3@186801|Clostridia	186801|Clostridia	S	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
SRD2_k127_500657_1	1144275.COCOR_01560	2.22e-15	81.0	COG0784@1|root,COG0784@2|Bacteria,1N7IK@1224|Proteobacteria,42VBR@68525|delta/epsilon subdivisions,2WRA1@28221|Deltaproteobacteria,2Z0IT@29|Myxococcales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
SRD2_k127_500657_0	562970.Btus_0232	7.989e-241	755.0	COG0459@1|root,COG0459@2|Bacteria,1TP1T@1239|Firmicutes,4HA38@91061|Bacilli,277XH@186823|Alicyclobacillaceae	91061|Bacilli	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0001817,GO:0001819,GO:0001871,GO:0002791,GO:0002793,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009986,GO:0009987,GO:0016465,GO:0030246,GO:0030247,GO:0032677,GO:0032757,GO:0032879,GO:0032880,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044764,GO:0046812,GO:0048518,GO:0048522,GO:0050707,GO:0050708,GO:0050714,GO:0050715,GO:0050789,GO:0050794,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051082,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051704,GO:0061077,GO:0065007,GO:0070201,GO:0090087,GO:0098630,GO:0098743,GO:0101031,GO:1903530,GO:1903532,GO:1904951,GO:1990220,GO:2000482,GO:2000484,GO:2001065	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
SRD2_k127_5007463_6	1125863.JAFN01000001_gene1913	2.579e-09	69.0	COG4447@1|root,COG4447@2|Bacteria,1MVIT@1224|Proteobacteria,42S9Y@68525|delta/epsilon subdivisions,2WNFW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
SRD2_k127_5007463_5	309799.DICTH_1264	5.968e-18	85.0	COG0267@1|root,COG0267@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
SRD2_k127_5007463_7	1380346.JNIH01000003_gene2010	1.824e-06	53.0	COG0690@1|root,COG0690@2|Bacteria,2GQFP@201174|Actinobacteria	201174|Actinobacteria	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
SRD2_k127_5007463_1	479434.Sthe_1608	3.692e-72	251.0	COG0250@1|root,COG0250@2|Bacteria,2G6A3@200795|Chloroflexi,27XZ9@189775|Thermomicrobia	189775|Thermomicrobia	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
SRD2_k127_5007463_2	196162.Noca_0696	1.152e-60	220.0	COG0080@1|root,COG0080@2|Bacteria,2IFCK@201174|Actinobacteria,4DQC0@85009|Propionibacteriales	201174|Actinobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
SRD2_k127_5007463_0	264732.Moth_2471	6.802e-94	314.0	COG0081@1|root,COG0081@2|Bacteria,1TPTS@1239|Firmicutes,247JB@186801|Clostridia,42ETC@68295|Thermoanaerobacterales	186801|Clostridia	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
SRD2_k127_5007463_4	1051632.TPY_0313	2.435e-38	150.0	COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes,24G9R@186801|Clostridia,3WCJV@538999|Clostridiales incertae sedis	186801|Clostridia	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
SRD2_k127_5007463_3	153948.NAL212_2141	2.466e-39	150.0	COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,2VSG7@28216|Betaproteobacteria,373C9@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
SRD2_k127_5008544_2	367299.JOEE01000008_gene371	3.542e-36	142.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4FEAH@85021|Intrasporangiaceae	201174|Actinobacteria	KLT	serine threonine protein kinase	pknL	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
SRD2_k127_5008544_3	981369.JQMJ01000004_gene1017	1.074e-20	98.0	COG0454@1|root,COG0456@2|Bacteria,2IPIF@201174|Actinobacteria,2NMID@228398|Streptacidiphilus	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SRD2_k127_5008544_0	479434.Sthe_3070	4.124e-118	393.0	COG0436@1|root,COG0436@2|Bacteria	2|Bacteria	E	Aminotransferase	-	-	2.6.1.1	ko:K11358	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
SRD2_k127_5008544_1	561175.KB894094_gene1959	3.705e-51	203.0	COG0515@1|root,COG0515@2|Bacteria,2GKFY@201174|Actinobacteria,4EI1G@85012|Streptosporangiales	201174|Actinobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
SRD2_k127_5008544_4	1449346.JQMO01000003_gene6223	4.265e-07	61.0	2BNAC@1|root,32GXY@2|Bacteria,2I1HN@201174|Actinobacteria,2M3WM@2063|Kitasatospora	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_5020914_2	383372.Rcas_1121	1.587e-07	55.0	COG3847@1|root,COG3847@2|Bacteria,2GB1R@200795|Chloroflexi,377RD@32061|Chloroflexia	32061|Chloroflexia	U	PFAM Flp Fap pilin component	-	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Flp_Fap
SRD2_k127_5020914_0	1038860.AXAP01000007_gene6070	9.769e-51	198.0	COG0642@1|root,COG2205@2|Bacteria,1N5YU@1224|Proteobacteria,2TTXK@28211|Alphaproteobacteria,3K5Y2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
SRD2_k127_5020914_1	710687.KI912270_gene4528	3.705e-19	88.0	COG0745@1|root,COG0745@2|Bacteria,2GMG9@201174|Actinobacteria,237WW@1762|Mycobacteriaceae	201174|Actinobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
SRD2_k127_5022659_2	450380.JPSY01000003_gene2629	3.525e-40	153.0	2DMKA@1|root,32S5N@2|Bacteria,2GYRE@201174|Actinobacteria	201174|Actinobacteria	S	SPW repeat	-	-	-	-	-	-	-	-	-	-	-	-	SPW
SRD2_k127_5022659_1	258533.BN977_03375	6.31e-84	304.0	COG4585@1|root,COG4585@2|Bacteria,2HDZV@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
SRD2_k127_5022659_0	1144275.COCOR_03165	3.96e-192	605.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1MU0R@1224|Proteobacteria,42NYJ@68525|delta/epsilon subdivisions,2WKYM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	GT	Phosphoenolpyruvate synthase	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
SRD2_k127_5033542_5	1068980.ARVW01000001_gene7482	4.496e-44	163.0	COG3795@1|root,COG3795@2|Bacteria,2IKRD@201174|Actinobacteria,4E51J@85010|Pseudonocardiales	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
SRD2_k127_5033542_7	1157708.KB907450_gene5105	1.624e-38	152.0	COG2315@1|root,COG2315@2|Bacteria,1RKYA@1224|Proteobacteria	1224|Proteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_5033542_9	298655.KI912266_gene3081	4.635e-33	140.0	COG0500@1|root,COG0500@2|Bacteria,2I3FS@201174|Actinobacteria	201174|Actinobacteria	Q	Pfam Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
SRD2_k127_5033542_6	1077972.ARGLB_056_00070	8.186e-39	150.0	COG1225@1|root,COG1225@2|Bacteria,2GKME@201174|Actinobacteria,1W9SJ@1268|Micrococcaceae	201174|Actinobacteria	O	Redoxin	ahpE	GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0020012,GO:0030682,GO:0042221,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0051920,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0070887,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	AhpC-TSA
SRD2_k127_5033542_3	387631.Asulf_02259	7.261e-53	190.0	COG0105@1|root,arCOG04313@2157|Archaea,2XWSK@28890|Euryarchaeota,2465T@183980|Archaeoglobi	183980|Archaeoglobi	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
SRD2_k127_5033542_1	1382306.JNIM01000001_gene1978	9.408e-94	322.0	COG0612@1|root,COG0612@2|Bacteria,2G672@200795|Chloroflexi	200795|Chloroflexi	S	PFAM peptidase M16 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
SRD2_k127_5033542_13	1382306.JNIM01000001_gene1925	4.812e-15	83.0	COG0537@1|root,COG0537@2|Bacteria	2|Bacteria	FG	bis(5'-adenosyl)-triphosphatase activity	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	ATP_bind_2,HIT
SRD2_k127_5033542_4	697281.Mahau_2963	9.47e-45	173.0	COG1847@1|root,COG1847@2|Bacteria,1V3IN@1239|Firmicutes,249EA@186801|Clostridia,42G7M@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM Single-stranded nucleic acid binding R3H	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
SRD2_k127_5033542_8	1262449.CP6013_3137	4.021e-33	140.0	COG0706@1|root,COG0706@2|Bacteria,1TQ0J@1239|Firmicutes,247V9@186801|Clostridia,36FE7@31979|Clostridiaceae	186801|Clostridia	U	Membrane protein insertase, YidC Oxa1 family	oxaA	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
SRD2_k127_5033542_11	1382356.JQMP01000003_gene1812	1.35e-21	95.0	COG0759@1|root,COG0759@2|Bacteria,2G76Q@200795|Chloroflexi,27YMP@189775|Thermomicrobia	189775|Thermomicrobia	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
SRD2_k127_5033542_12	42256.RradSPS_2771	4.717e-17	89.0	COG0594@1|root,COG0594@2|Bacteria,2GR42@201174|Actinobacteria,4CQCA@84995|Rubrobacteria	84995|Rubrobacteria	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
SRD2_k127_5033542_14	309799.DICTH_1849	2.116e-13	70.0	COG0230@1|root,COG0230@2|Bacteria	2|Bacteria	J	Ribosomal protein L34	rpmH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
SRD2_k127_5033542_0	646529.Desaci_0002	1.443e-147	480.0	COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,2490S@186801|Clostridia,260P2@186807|Peptococcaceae	186801|Clostridia	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
SRD2_k127_5033542_2	525904.Tter_0993	1.34e-80	282.0	COG0592@1|root,COG0592@2|Bacteria,2NP7D@2323|unclassified Bacteria	2|Bacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
SRD2_k127_5033542_10	1485543.JMME01000003_gene2039	2.292e-22	104.0	COG1195@1|root,COG1195@2|Bacteria,1TP9U@1239|Firmicutes,4H1XT@909932|Negativicutes	909932|Negativicutes	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
SRD2_k127_5036461_1	1283299.AUKG01000002_gene3974	4.776e-24	106.0	COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria,4CRTX@84995|Rubrobacteria	84995|Rubrobacteria	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N
SRD2_k127_5036461_0	469383.Cwoe_0960	6.549e-154	493.0	COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria,4CPSQ@84995|Rubrobacteria	84995|Rubrobacteria	I	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SRD2_k127_5066164_2	867903.ThesuDRAFT_01320	3.904e-102	341.0	COG0208@1|root,COG0208@2|Bacteria,1UYGN@1239|Firmicutes	1239|Firmicutes	F	Ribonucleotide reductase, small chain	-	-	1.17.4.1	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_sm
SRD2_k127_5066164_4	102129.Lepto7375DRAFT_4117	5.362e-62	220.0	COG3467@1|root,COG3467@2|Bacteria,1G4RC@1117|Cyanobacteria	1117|Cyanobacteria	S	Flavin-nucleotide-binding protein	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
SRD2_k127_5066164_3	1122939.ATUD01000001_gene613	6.122e-79	277.0	COG2267@1|root,COG2267@2|Bacteria,2I79Z@201174|Actinobacteria	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
SRD2_k127_5066164_0	40571.JOEA01000001_gene5434	5.868e-196	632.0	COG1154@1|root,COG1154@2|Bacteria,2GMFA@201174|Actinobacteria,4DXY8@85010|Pseudonocardiales	201174|Actinobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0008661,GO:0009058,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030145,GO:0030975,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901363,GO:1901576,GO:1901681	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
SRD2_k127_5066164_1	234267.Acid_6457	4.431e-121	406.0	COG1914@1|root,COG1914@2|Bacteria	2|Bacteria	P	metal ion transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
SRD2_k127_5066164_5	1095769.CAHF01000006_gene1856	3.798e-60	211.0	COG5637@1|root,COG5637@2|Bacteria,1RCEX@1224|Proteobacteria,2VQP4@28216|Betaproteobacteria,4771P@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
SRD2_k127_5066164_6	1150864.MILUP08_42335	6.419e-59	212.0	COG0546@1|root,COG0546@2|Bacteria,2GIU8@201174|Actinobacteria,4DD8S@85008|Micromonosporales	201174|Actinobacteria	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
SRD2_k127_5066164_7	521011.Mpal_2558	4.388e-57	204.0	COG0693@1|root,arCOG00769@2157|Archaea,2XTPH@28890|Euryarchaeota,2N9UJ@224756|Methanomicrobia	224756|Methanomicrobia	O	TIGRFAM intracellular protease, PfpI family	-	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
SRD2_k127_5077833_0	1415779.JOMH01000001_gene2126	2.075e-13	74.0	COG5276@1|root,COG5276@2|Bacteria,1R8ZW@1224|Proteobacteria,1S0TP@1236|Gammaproteobacteria,1X52T@135614|Xanthomonadales	135614|Xanthomonadales	S	repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
SRD2_k127_5077833_1	1209072.ALBT01000007_gene2781	1.313e-10	75.0	COG2931@1|root,COG2982@1|root,COG4733@1|root,COG4932@1|root,COG2931@2|Bacteria,COG2982@2|Bacteria,COG4733@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	ko:K11005	-	-	-	-	ko00000,ko02000,ko02042	1.C.11	-	-	Cadherin_3,Calx-beta,He_PIG,HemolysinCabind,VWA_2
SRD2_k127_5102843_15	1229780.BN381_80233	7.429e-57	207.0	COG4658@1|root,COG4658@2|Bacteria	2|Bacteria	C	electron transport chain	-	-	1.6.5.8	ko:K00347,ko:K03614,ko:K21163	ko01059,ko01130,map01059,map01130	M00824	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Complex1_51K,NQR2_RnfD_RnfE,RnfC_N,UnbV_ASPIC,VCBS
SRD2_k127_5102843_32	1121355.KB903379_gene745	1.533e-06	53.0	COG0544@1|root,COG0544@2|Bacteria,2GJIG@201174|Actinobacteria,22JV9@1653|Corynebacteriaceae	201174|Actinobacteria	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
SRD2_k127_5102843_16	1054860.KB913030_gene6184	1.412e-52	195.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
SRD2_k127_5102843_19	525904.Tter_2084	9.526e-28	118.0	COG0517@1|root,COG0517@2|Bacteria	2|Bacteria	S	IMP dehydrogenase activity	-	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	CBS
SRD2_k127_5102843_27	1211815.CBYP010000062_gene3178	6.385e-15	81.0	COG0607@1|root,COG0607@2|Bacteria	2|Bacteria	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
SRD2_k127_5102843_20	1144275.COCOR_03122	1.4e-27	116.0	COG3832@1|root,COG5646@1|root,COG3832@2|Bacteria,COG5646@2|Bacteria,1NKMZ@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,DUF1801
SRD2_k127_5102843_14	1394178.AWOO02000074_gene2250	9.299e-62	222.0	COG0221@1|root,COG0221@2|Bacteria,2GM7F@201174|Actinobacteria,4EHYC@85012|Streptosporangiales	201174|Actinobacteria	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	GO:0000287,GO:0003674,GO:0003824,GO:0004427,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0071944	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3628	Pyrophosphatase
SRD2_k127_5102843_12	311424.DhcVS_642	2.766e-69	244.0	COG1028@1|root,COG1028@2|Bacteria,2G6RP@200795|Chloroflexi,34CMA@301297|Dehalococcoidia	301297|Dehalococcoidia	IQ	KR domain	-	-	1.1.1.127	ko:K00065	ko00040,map00040	-	R01542	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
SRD2_k127_5102843_18	219305.MCAG_02464	7.116e-38	147.0	COG0251@1|root,COG0251@2|Bacteria,2IHNE@201174|Actinobacteria,4DDVD@85008|Micromonosporales	201174|Actinobacteria	J	YjgF/chorismate_mutase-like, putative endoribonuclease	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
SRD2_k127_5102843_2	66897.DJ64_22060	1.09e-163	520.0	COG0667@1|root,COG0667@2|Bacteria,2GMNA@201174|Actinobacteria	201174|Actinobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SRD2_k127_5102843_4	1121372.AULK01000001_gene1856	5.478e-141	464.0	COG0701@1|root,COG3350@1|root,COG0701@2|Bacteria,COG3350@2|Bacteria,2GJWR@201174|Actinobacteria	201174|Actinobacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
SRD2_k127_5102843_30	246197.MXAN_5221	3.694e-12	73.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009438,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019172,GO:0019243,GO:0019249,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046185,GO:0046394,GO:0051596,GO:0061727,GO:0071704,GO:0072330,GO:1901575,GO:1901576,GO:1901615,GO:1901617	-	ko:K18991	-	M00647	-	-	ko00000,ko00002,ko03000	-	-	-	AraC_binding,Cupin_6,HTH_18,HTH_AraC
SRD2_k127_5102843_8	345341.KUTG_03011	1.569e-116	390.0	COG4097@1|root,COG4097@2|Bacteria,2GKWX@201174|Actinobacteria,4DZEG@85010|Pseudonocardiales	201174|Actinobacteria	P	Ferric reductase like transmembrane component	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_8,Ferric_reduct,NAD_binding_1
SRD2_k127_5102843_21	1380346.JNIH01000063_gene2525	1.019e-24	110.0	COG3976@1|root,COG3976@2|Bacteria,2GTTI@201174|Actinobacteria	201174|Actinobacteria	S	FMN-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind
SRD2_k127_5102843_13	749414.SBI_02891	1.242e-64	232.0	COG1477@1|root,COG1477@2|Bacteria,2GN6F@201174|Actinobacteria	201174|Actinobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
SRD2_k127_5102843_24	405948.SACE_2418	1.28e-18	93.0	COG0517@1|root,COG0517@2|Bacteria,2I3TG@201174|Actinobacteria,4EC77@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SRD2_k127_5102843_6	653733.Selin_1410	3.261e-131	441.0	COG1022@1|root,COG1022@2|Bacteria	2|Bacteria	I	Amp-dependent synthetase and ligase	fadD	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
SRD2_k127_5102843_17	710696.Intca_2822	8.109e-44	170.0	COG2210@1|root,COG2210@2|Bacteria,2IGW8@201174|Actinobacteria	201174|Actinobacteria	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
SRD2_k127_5102843_26	1033739.CAEU01000031_gene1648	1.167e-16	91.0	COG0425@1|root,COG0425@2|Bacteria,1VEEC@1239|Firmicutes	1239|Firmicutes	O	Belongs to the sulfur carrier protein TusA family	yrkI	-	-	-	-	-	-	-	-	-	-	-	TusA
SRD2_k127_5102843_5	351607.Acel_0523	1.8e-138	451.0	COG0446@1|root,COG0446@2|Bacteria,2GRTN@201174|Actinobacteria,4ESWT@85013|Frankiales	201174|Actinobacteria	S	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	DsrC,Pyr_redox_2
SRD2_k127_5102843_23	324602.Caur_0571	1.214e-18	89.0	COG0425@1|root,COG0425@2|Bacteria	2|Bacteria	O	sulfur carrier activity	-	-	-	-	-	-	-	-	-	-	-	-	TusA
SRD2_k127_5102843_22	351607.Acel_0525	1.118e-20	96.0	COG2210@1|root,COG2210@2|Bacteria,2IFXH@201174|Actinobacteria,4EWZZ@85013|Frankiales	201174|Actinobacteria	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
SRD2_k127_5102843_28	1335757.SPICUR_03560	1.038e-14	84.0	COG0640@1|root,COG0640@2|Bacteria,1QPHU@1224|Proteobacteria,1SJ8P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Regulatory protein ArsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
SRD2_k127_5102843_33	94624.Bpet1843	0.0004327	49.0	COG5637@1|root,COG5637@2|Bacteria,1RI3F@1224|Proteobacteria,2WGS9@28216|Betaproteobacteria	28216|Betaproteobacteria	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON,Polyketide_cyc
SRD2_k127_5102843_0	1382356.JQMP01000001_gene727	1.217e-261	830.0	COG1067@1|root,COG1067@2|Bacteria,2G64R@200795|Chloroflexi,27XSI@189775|Thermomicrobia	189775|Thermomicrobia	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
SRD2_k127_5102843_1	351607.Acel_1545	5.057e-187	611.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4ERWA@85013|Frankiales	201174|Actinobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	ctpE	GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	-	ko:K12952	-	-	-	-	ko00000,ko01000	3.A.3.23	-	-	E1-E2_ATPase,Hydrolase
SRD2_k127_5102843_11	1380390.JIAT01000010_gene3637	1.686e-76	268.0	COG1752@1|root,COG1752@2|Bacteria,2IB0F@201174|Actinobacteria,4CR75@84995|Rubrobacteria	84995|Rubrobacteria	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
SRD2_k127_5102843_10	263358.VAB18032_27931	3.615e-80	281.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2GJBZ@201174|Actinobacteria,4DCDB@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
SRD2_k127_5102843_29	211114.JOEF01000026_gene367	2.784e-14	81.0	COG3409@1|root,COG3409@2|Bacteria,2HUBB@201174|Actinobacteria,4E7IY@85010|Pseudonocardiales	201174|Actinobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_5102843_25	1254432.SCE1572_36845	2.557e-18	87.0	COG0236@1|root,COG0236@2|Bacteria,1NHIC@1224|Proteobacteria,42X69@68525|delta/epsilon subdivisions,2WSMW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
SRD2_k127_5102843_7	1151119.KB895489_gene647	7.893e-124	409.0	COG0508@1|root,COG0508@2|Bacteria,2GN5J@201174|Actinobacteria	201174|Actinobacteria	C	acetyltransferase component of pyruvate dehydrogenase complex	-	-	2.3.1.12,2.3.1.61	ko:K00627,ko:K00658	ko00010,ko00020,ko00310,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00310,map00620,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032,M00307	R00209,R02569,R02570,R02571,R08549	RC00004,RC02727,RC02742,RC02833,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
SRD2_k127_5102843_3	930171.Asphe3_00700	4.739e-158	505.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria	201174|Actinobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
SRD2_k127_5102843_9	177439.DPPB38	2.39e-90	301.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,42MHF@68525|delta/epsilon subdivisions,2WJ1R@28221|Deltaproteobacteria,2MMYC@213118|Desulfobacterales	28221|Deltaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
SRD2_k127_5120379_5	483219.LILAB_09685	3.883e-27	113.0	COG3631@1|root,COG3631@2|Bacteria,1RDED@1224|Proteobacteria,43810@68525|delta/epsilon subdivisions,2X3B2@28221|Deltaproteobacteria,2YV6Y@29|Myxococcales	28221|Deltaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
SRD2_k127_5120379_0	319795.Dgeo_1547	4.533e-108	368.0	COG0624@1|root,COG0624@2|Bacteria,1WIJT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	PFAM Peptidase family M20 M25 M40	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
SRD2_k127_5120379_1	1382356.JQMP01000003_gene1617	3.443e-54	218.0	COG2206@1|root,COG2206@2|Bacteria,2GBKK@200795|Chloroflexi	200795|Chloroflexi	T	metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,Response_reg
SRD2_k127_5120379_3	35703.DQ02_04355	1.521e-45	190.0	COG2211@1|root,COG2211@2|Bacteria,1R8C2@1224|Proteobacteria	1224|Proteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SRD2_k127_5120379_2	999541.bgla_1g30150	2.973e-48	187.0	COG0697@1|root,COG0697@2|Bacteria,1NFUD@1224|Proteobacteria,2VPJH@28216|Betaproteobacteria,1K0I0@119060|Burkholderiaceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SRD2_k127_5120379_4	637389.Acaty_c0048	6.475e-30	128.0	COG1639@1|root,COG2199@1|root,COG1639@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1RX09@1236|Gammaproteobacteria,2NDV0@225057|Acidithiobacillales	225057|Acidithiobacillales	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HDOD,Response_reg
SRD2_k127_5137507_4	1118153.MOY_12072	1.708e-17	88.0	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,1RM7U@1236|Gammaproteobacteria,1XHFQ@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
SRD2_k127_5137507_0	292459.STH881	1.041e-254	801.0	COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes	1239|Firmicutes	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
SRD2_k127_5137507_1	243231.GSU0652	1.349e-112	371.0	COG0171@1|root,COG0171@2|Bacteria,1MU9U@1224|Proteobacteria,42N86@68525|delta/epsilon subdivisions,2WIV4@28221|Deltaproteobacteria,43VVZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
SRD2_k127_5137507_2	671143.DAMO_2425	9.079e-81	279.0	COG0388@1|root,COG0388@2|Bacteria,2NQD8@2323|unclassified Bacteria	2|Bacteria	S	Carbon-nitrogen hydrolase	-	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase
SRD2_k127_5137507_3	1382356.JQMP01000003_gene2368	3.011e-61	220.0	COG1199@1|root,COG2176@1|root,COG1199@2|Bacteria,COG2176@2|Bacteria,2G5P4@200795|Chloroflexi,27XGW@189775|Thermomicrobia	189775|Thermomicrobia	L	HELICc2	-	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD_2,Helicase_C_2,RNase_T
SRD2_k127_5141786_1	298655.KI912266_gene2102	5.217e-31	127.0	COG3467@1|root,COG3467@2|Bacteria	2|Bacteria	T	pyridoxamine 5'-phosphate	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Putative_PNPOx,Pyridox_ox_2
SRD2_k127_5141786_0	882083.SacmaDRAFT_3025	1.129e-147	478.0	COG1680@1|root,COG1680@2|Bacteria,2I2WV@201174|Actinobacteria,4EDVP@85010|Pseudonocardiales	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SRD2_k127_5149001_11	1121324.CLIT_23c00460	2.754e-07	61.0	COG4961@1|root,COG4961@2|Bacteria,1VFNR@1239|Firmicutes,24R06@186801|Clostridia	186801|Clostridia	U	PFAM TadE family protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
SRD2_k127_5149001_3	1306174.JODP01000009_gene6553	3.805e-38	155.0	COG2064@1|root,COG2064@2|Bacteria,2GK7B@201174|Actinobacteria	201174|Actinobacteria	NU	Type ii secretion system	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
SRD2_k127_5149001_4	1120985.AUMI01000014_gene1067	1.741e-37	156.0	COG4965@1|root,COG4965@2|Bacteria,1UZ3V@1239|Firmicutes,4H3YR@909932|Negativicutes	909932|Negativicutes	U	Type II secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
SRD2_k127_5149001_10	1713.JOFV01000001_gene2081	1.154e-08	66.0	COG3745@1|root,COG3745@2|Bacteria,2HXY8@201174|Actinobacteria,4F1MK@85016|Cellulomonadaceae	201174|Actinobacteria	U	SAF	-	-	-	-	-	-	-	-	-	-	-	-	SAF
SRD2_k127_5149001_6	443143.GM18_2436	5.965e-25	115.0	COG2197@1|root,COG4963@1|root,COG2197@2|Bacteria,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,42QEH@68525|delta/epsilon subdivisions,2WKVC@28221|Deltaproteobacteria,43SJ6@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Flp pilus polar localization response receiver ATPase TadZ, FlhG domain-containing	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CBP_BcsQ,ParA,Response_reg
SRD2_k127_5149001_9	338963.Pcar_2037	7.532e-13	80.0	2B9FT@1|root,322TS@2|Bacteria,1RKUJ@1224|Proteobacteria,42SNA@68525|delta/epsilon subdivisions,2WPES@28221|Deltaproteobacteria,43SKX@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_5149001_5	292459.STH494	4.659e-26	115.0	COG0746@1|root,COG0746@2|Bacteria,1VA6T@1239|Firmicutes,24JG6@186801|Clostridia	186801|Clostridia	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752,ko:K13818	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
SRD2_k127_5149001_2	1150864.MILUP08_41105	8.8e-55	199.0	COG1678@1|root,COG1678@2|Bacteria,2GNRA@201174|Actinobacteria,4DBT1@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the UPF0301 (AlgH) family	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
SRD2_k127_5149001_12	1121468.AUBR01000006_gene351	4.963e-05	54.0	2E4CV@1|root,32Z89@2|Bacteria,1VIUI@1239|Firmicutes,24TAY@186801|Clostridia,42JDQ@68295|Thermoanaerobacterales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2680
SRD2_k127_5149001_7	485913.Krac_9920	3.887e-23	100.0	COG0695@1|root,COG0695@2|Bacteria,2G75B@200795|Chloroflexi	200795|Chloroflexi	O	Glutathione S-transferase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
SRD2_k127_5149001_8	575590.HMPREF0156_01407	7.024e-16	85.0	COG1308@1|root,COG1308@2|Bacteria,4NVAE@976|Bacteroidetes	976|Bacteroidetes	K	Domain of unknown function (DUF4342)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4342
SRD2_k127_5149001_1	469383.Cwoe_1890	3.928e-117	389.0	COG1363@1|root,COG1363@2|Bacteria,2I6I7@201174|Actinobacteria	201174|Actinobacteria	G	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
SRD2_k127_5149001_0	1169161.KB897740_gene2227	1.231e-175	560.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
SRD2_k127_5150138_5	1463825.JNXC01000030_gene396	5.121e-09	62.0	COG2079@1|root,COG2079@2|Bacteria,2GKUR@201174|Actinobacteria,4E0R9@85010|Pseudonocardiales	201174|Actinobacteria	S	protein involved in propionate catabolism	prpD	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
SRD2_k127_5150138_3	649831.L083_2338	4.133e-34	145.0	COG1597@1|root,COG1597@2|Bacteria	2|Bacteria	I	lipid kinase activity	bmrU	-	2.7.1.107	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	-	R02240	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_cat
SRD2_k127_5150138_6	1122611.KB903940_gene1856	8.284e-07	57.0	COG3945@1|root,COG3945@2|Bacteria,2I92G@201174|Actinobacteria,4EI2N@85012|Streptosporangiales	201174|Actinobacteria	S	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red,Hemerythrin
SRD2_k127_5150138_4	1192034.CAP_2726	1.099e-29	125.0	COG2050@1|root,COG2050@2|Bacteria	2|Bacteria	Q	thiolester hydrolase activity	ydiI	-	-	-	-	-	-	-	-	-	-	-	4HBT,Hydrolase_3
SRD2_k127_5150138_2	525904.Tter_1681	4.327e-45	183.0	COG2843@1|root,COG3103@1|root,COG2843@2|Bacteria,COG4991@2|Bacteria,2NPJI@2323|unclassified Bacteria	2|Bacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	2.7.11.1	ko:K07282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PGA_cap,SH3_3,SH3_4
SRD2_k127_5150138_0	235985.BBPN01000002_gene5137	3.213e-111	382.0	COG4677@1|root,COG4677@2|Bacteria,2I5JZ@201174|Actinobacteria,2NKFF@228398|Streptacidiphilus	201174|Actinobacteria	G	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
SRD2_k127_5150138_1	235985.BBPN01000002_gene5137	8.014e-99	348.0	COG4677@1|root,COG4677@2|Bacteria,2I5JZ@201174|Actinobacteria,2NKFF@228398|Streptacidiphilus	201174|Actinobacteria	G	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
SRD2_k127_5166931_14	479433.Caci_5853	7.006e-08	64.0	COG0366@1|root,COG0366@2|Bacteria,2GJUT@201174|Actinobacteria	201174|Actinobacteria	G	alpha amylase, catalytic	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,Alpha-amylase_C,CBM_20,TIG
SRD2_k127_5166931_11	1183438.GKIL_2486	5.529e-25	116.0	298HN@1|root,2ZVNP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_5166931_15	1197130.BAFM01000011_gene2051	1.567e-06	59.0	arCOG08099@1|root,arCOG08099@2157|Archaea,2XTZD@28890|Euryarchaeota,23S2K@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_5166931_10	479432.Sros_4108	4.623e-25	108.0	COG0346@1|root,COG0346@2|Bacteria,2IM7G@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SRD2_k127_5166931_1	68260.JOAY01000027_gene4171	7.665e-143	473.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SRD2_k127_5166931_3	448385.sce8562	1.133e-102	343.0	COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,43AJI@68525|delta/epsilon subdivisions,2X5ZR@28221|Deltaproteobacteria,2YV0D@29|Myxococcales	28221|Deltaproteobacteria	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
SRD2_k127_5166931_0	469383.Cwoe_4550	3.737e-221	704.0	COG0300@1|root,COG3320@1|root,COG0300@2|Bacteria,COG3320@2|Bacteria,2GJ1R@201174|Actinobacteria,4CR82@84995|Rubrobacteria	84995|Rubrobacteria	Q	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_4,adh_short
SRD2_k127_5166931_4	656024.FsymDg_0960	1.011e-90	305.0	COG0483@1|root,COG0483@2|Bacteria,2GKZZ@201174|Actinobacteria,4ERCV@85013|Frankiales	201174|Actinobacteria	G	PFAM Inositol monophosphatase	hisN	-	3.1.3.15,3.1.3.25	ko:K01092,ko:K05602	ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00340,map00521,map00562,map01100,map01110,map01230,map04070	M00026,M00131	R01185,R01186,R01187,R03013	RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
SRD2_k127_5166931_13	244447.XP_008317864.1	2.117e-08	61.0	KOG4498@1|root,KOG4498@2759|Eukaryota,39R4K@33154|Opisthokonta,3BAQH@33208|Metazoa,3D3F7@33213|Bilateria,486KK@7711|Chordata,498J0@7742|Vertebrata,49YWM@7898|Actinopterygii	33208|Metazoa	S	Family with sequence similarity 213 member B	FAM213B	GO:0001516,GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006636,GO:0006690,GO:0006692,GO:0006693,GO:0008150,GO:0008152,GO:0008379,GO:0008610,GO:0009058,GO:0009636,GO:0009987,GO:0012505,GO:0016053,GO:0016209,GO:0016491,GO:0016614,GO:0016616,GO:0016684,GO:0019752,GO:0032787,GO:0033559,GO:0042221,GO:0043209,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046456,GO:0046457,GO:0047017,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070887,GO:0071704,GO:0072330,GO:0097237,GO:0098754,GO:0098869,GO:1901568,GO:1901570,GO:1901576,GO:1990748	1.11.1.20	ko:K15717	ko00590,ko01100,map00590,map01100	-	R09506	RC00671	ko00000,ko00001,ko01000	-	-	-	AhpC-TSA_2
SRD2_k127_5166931_6	273068.TTE0518	2.291e-49	201.0	COG2206@1|root,COG2206@2|Bacteria,1UZN2@1239|Firmicutes,248SE@186801|Clostridia,42F3X@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM Metal-dependent phosphohydrolase, HD	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
SRD2_k127_5166931_5	933115.GPDM_15209	9.852e-72	264.0	COG1404@1|root,COG1404@2|Bacteria,1TQRU@1239|Firmicutes,4HAZA@91061|Bacilli	91061|Bacilli	O	Belongs to the peptidase S8 family	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S8
SRD2_k127_5166931_8	661478.OP10G_4211	3.492e-43	173.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
SRD2_k127_5166931_2	1242864.D187_000626	1.2e-106	355.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,42MA4@68525|delta/epsilon subdivisions,2WIPU@28221|Deltaproteobacteria,2YZ50@29|Myxococcales	28221|Deltaproteobacteria	I	Enoyl-(Acyl carrier protein) reductase	fabI	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SRD2_k127_5166931_7	345341.KUTG_02226	8.231e-44	166.0	COG1595@1|root,COG1595@2|Bacteria,2IG1M@201174|Actinobacteria,4E9SD@85010|Pseudonocardiales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
SRD2_k127_5166931_9	1123023.JIAI01000002_gene5468	1.148e-33	139.0	COG2146@1|root,COG2146@2|Bacteria	2|Bacteria	P	nitrite reductase [NAD(P)H] activity	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
SRD2_k127_5166931_16	1122182.KB903837_gene3847	0.0003709	52.0	COG3794@1|root,COG3794@2|Bacteria,2HWTN@201174|Actinobacteria,4DKBH@85008|Micromonosporales	201174|Actinobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
SRD2_k127_5166931_17	469383.Cwoe_4181	0.0004214	50.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_5176784_5	1449044.JMLE01000012_gene3026	1.998e-07	55.0	COG0346@1|root,COG0346@2|Bacteria,2IM7G@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SRD2_k127_5176784_1	566461.SSFG_06440	1.018e-63	236.0	COG1835@1|root,COG1835@2|Bacteria,2GKUS@201174|Actinobacteria	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
SRD2_k127_5176784_0	1235457.C404_02685	3.845e-149	481.0	COG0111@1|root,COG0111@2|Bacteria,1MW0R@1224|Proteobacteria,2W8WY@28216|Betaproteobacteria,1KDAI@119060|Burkholderiaceae	28216|Betaproteobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
SRD2_k127_5176784_4	35754.JNYJ01000014_gene4857	1.142e-39	156.0	COG1309@1|root,COG1309@2|Bacteria,2IKK0@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
SRD2_k127_5176784_2	314256.OG2516_13274	3.843e-63	221.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SRD2_k127_5176784_3	28444.JODQ01000001_gene2425	1.986e-47	176.0	COG4585@1|root,COG4585@2|Bacteria,2GMMU@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
SRD2_k127_5193698_13	1382306.JNIM01000001_gene664	2.766e-69	247.0	COG0215@1|root,COG0215@2|Bacteria,2G5Z0@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	-	-	-	-	-	-	-	-	-	-	tRNA-synt_1e
SRD2_k127_5193698_2	1313172.YM304_25950	3.128e-154	506.0	COG1351@1|root,COG1351@2|Bacteria,2HBYZ@201174|Actinobacteria,4CMUK@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	-	-	-	-	-	-	-	-	-	-	-	-	Thy1
SRD2_k127_5193698_28	1380390.JIAT01000014_gene6030	1.539e-29	126.0	COG0494@1|root,COG0494@2|Bacteria,2GKG9@201174|Actinobacteria,4CQAZ@84995|Rubrobacteria	84995|Rubrobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
SRD2_k127_5193698_34	1288494.EBAPG3_27550	4.515e-08	65.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,2VIRX@28216|Betaproteobacteria,372EF@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
SRD2_k127_5193698_15	1382306.JNIM01000001_gene3401	2.228e-61	226.0	COG1600@1|root,COG1600@2|Bacteria,2G6A0@200795|Chloroflexi	200795|Chloroflexi	C	4Fe-4S double cluster binding domain	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Dehalogenase,Fer4_16,HEAT_2
SRD2_k127_5193698_3	926550.CLDAP_00500	2.24e-151	489.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,2G5TN@200795|Chloroflexi	200795|Chloroflexi	HP	PFAM UBA THIF-type NAD FAD binding protein	-	-	2.7.7.80,2.8.1.11	ko:K21029,ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
SRD2_k127_5193698_8	765420.OSCT_3169	2.629e-86	306.0	COG0260@1|root,COG0260@2|Bacteria,2G617@200795|Chloroflexi,37528@32061|Chloroflexia	32061|Chloroflexia	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
SRD2_k127_5193698_7	1121472.AQWN01000006_gene1806	1.079e-88	303.0	COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia,2604F@186807|Peptococcaceae	186801|Clostridia	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
SRD2_k127_5193698_30	1169152.AXVD01000014_gene1480	2.266e-24	115.0	2CDI5@1|root,2Z7ZQ@2|Bacteria,2I8FG@201174|Actinobacteria,4G3G2@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_5193698_20	28444.JODQ01000002_gene4323	1.072e-52	196.0	COG2120@1|root,COG2120@2|Bacteria,2GMVD@201174|Actinobacteria,4EGBS@85012|Streptosporangiales	201174|Actinobacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
SRD2_k127_5193698_31	313590.MED134_06744	1.728e-21	108.0	COG2244@1|root,COG2244@2|Bacteria,4NG0R@976|Bacteroidetes,1HXJY@117743|Flavobacteriia,37E86@326319|Dokdonia	976|Bacteroidetes	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3
SRD2_k127_5193698_11	401053.AciPR4_1066	2.65e-71	246.0	COG0302@1|root,COG0302@2|Bacteria,3Y2SP@57723|Acidobacteria,2JIR1@204432|Acidobacteriia	204432|Acidobacteriia	H	TIGRFAM GTP cyclohydrolase I	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
SRD2_k127_5193698_22	1382306.JNIM01000001_gene3962	3.597e-47	194.0	COG0652@1|root,COG0652@2|Bacteria,2G6RE@200795|Chloroflexi	200795|Chloroflexi	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K01802,ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
SRD2_k127_5193698_21	649638.Trad_0538	9.544e-50	189.0	COG2110@1|root,COG2110@2|Bacteria,1WJ1P@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	phosphatase homologous to the C-terminal domain of histone macroH2A1	-	-	-	-	-	-	-	-	-	-	-	-	Macro
SRD2_k127_5193698_33	1218075.BAYA01000001_gene391	3.989e-14	79.0	COG0622@1|root,COG0622@2|Bacteria,1RGUN@1224|Proteobacteria,2VT3X@28216|Betaproteobacteria,1K716@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Phosphoesterase	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
SRD2_k127_5193698_4	215803.DB30_0442	1.821e-146	492.0	COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,42QCJ@68525|delta/epsilon subdivisions,2WKE7@28221|Deltaproteobacteria,2YUF8@29|Myxococcales	28221|Deltaproteobacteria	G	Glycosyl hydrolases family 15	-	-	-	-	-	-	-	-	-	-	-	-	DUF547,Glyco_hydro_15
SRD2_k127_5193698_12	1173022.Cri9333_4028	6.013e-71	255.0	COG1028@1|root,COG1028@2|Bacteria,1G0IE@1117|Cyanobacteria,1H74G@1150|Oscillatoriales	1117|Cyanobacteria	IQ	with different specificities (related to short-chain alcohol	-	-	1.1.1.47	ko:K00034	ko00030,ko01120,ko01200,map00030,map01120,map01200	-	R01520,R01521	RC00066	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
SRD2_k127_5193698_24	1144275.COCOR_01564	4.357e-45	171.0	COG0122@1|root,COG0122@2|Bacteria,1MX9C@1224|Proteobacteria,42USD@68525|delta/epsilon subdivisions,2WQCM@28221|Deltaproteobacteria,2YXGM@29|Myxococcales	28221|Deltaproteobacteria	L	endonuclease III	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
SRD2_k127_5193698_23	471852.Tcur_0827	1.71e-46	172.0	COG0748@1|root,COG0748@2|Bacteria,2IFHD@201174|Actinobacteria,4EK8J@85012|Streptosporangiales	201174|Actinobacteria	P	pyridoxamine 5-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
SRD2_k127_5193698_25	1206731.BAGB01000174_gene2074	2.374e-35	143.0	COG0748@1|root,COG0748@2|Bacteria,2I3CW@201174|Actinobacteria,4G8PK@85025|Nocardiaceae	201174|Actinobacteria	P	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
SRD2_k127_5193698_19	1254432.SCE1572_21240	1.141e-54	212.0	COG0266@1|root,COG0266@2|Bacteria,1N1J5@1224|Proteobacteria,433TA@68525|delta/epsilon subdivisions,2X3D6@28221|Deltaproteobacteria,2YVHV@29|Myxococcales	28221|Deltaproteobacteria	L	Belongs to the FPG family	-	-	4.2.99.18	ko:K05522	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
SRD2_k127_5193698_0	1179773.BN6_16710	0.0	1476.0	COG1201@1|root,COG1201@2|Bacteria,2GJG3@201174|Actinobacteria,4E13K@85010|Pseudonocardiales	201174|Actinobacteria	L	DEAD DEAH box helicase	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,HTH_42,Helicase_C
SRD2_k127_5193698_32	485913.Krac_9923	7.928e-20	98.0	COG3861@1|root,COG3861@2|Bacteria,2G9D9@200795|Chloroflexi	200795|Chloroflexi	S	Cation transport regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_5193698_10	1382306.JNIM01000001_gene3038	5.56e-80	284.0	COG1457@1|root,COG1457@2|Bacteria,2G9KC@200795|Chloroflexi	200795|Chloroflexi	F	Permease for cytosine/purines, uracil, thiamine, allantoin	-	-	-	-	-	-	-	-	-	-	-	-	Transp_cyt_pur
SRD2_k127_5193698_14	479434.Sthe_1496	1.221e-66	253.0	COG0351@1|root,COG0351@2|Bacteria,2G5R7@200795|Chloroflexi,27XQP@189775|Thermomicrobia	189775|Thermomicrobia	H	Phosphomethylpyrimidine kinase	-	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
SRD2_k127_5193698_29	1173263.Syn7502_02514	9.668e-26	123.0	COG0739@1|root,COG0739@2|Bacteria,1G1GS@1117|Cyanobacteria,1GYDA@1129|Synechococcus	1117|Cyanobacteria	M	COG0739 Membrane proteins related to metalloendopeptidases	-	-	3.4.24.75	ko:K08259	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	LysM,Peptidase_M23
SRD2_k127_5193698_26	1463887.KL589964_gene7694	1.99e-31	132.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SRD2_k127_5193698_1	479434.Sthe_1235	2.04e-177	567.0	COG1233@1|root,COG1233@2|Bacteria,2G60T@200795|Chloroflexi,27XJE@189775|Thermomicrobia	189775|Thermomicrobia	Q	NAD(P)-binding Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
SRD2_k127_5193698_6	1385518.N798_16405	1.647e-122	401.0	COG0664@1|root,COG0664@2|Bacteria,2ID3H@201174|Actinobacteria	201174|Actinobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
SRD2_k127_5193698_9	469383.Cwoe_4828	3.237e-84	303.0	28JQV@1|root,2Z9GM@2|Bacteria,2H335@201174|Actinobacteria,4CPRQ@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_5193698_27	589865.DaAHT2_2550	2.426e-30	131.0	COG1648@1|root,COG1648@2|Bacteria,1RB3H@1224|Proteobacteria,42QT2@68525|delta/epsilon subdivisions,2WN1F@28221|Deltaproteobacteria,2MJPS@213118|Desulfobacterales	28221|Deltaproteobacteria	H	TIGRFAM siroheme synthase	cysG	-	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_binding_7,Sirohm_synth_M
SRD2_k127_5193698_17	1168059.KB899087_gene1701	5.857e-58	220.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2TSH9@28211|Alphaproteobacteria,3EZ8F@335928|Xanthobacteraceae	28211|Alphaproteobacteria	P	ATPases associated with a variety of cellular activities	tauB	GO:0003674,GO:0003824,GO:0005215,GO:0005342,GO:0005368,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008150,GO:0008509,GO:0008514,GO:0008559,GO:0015075,GO:0015238,GO:0015399,GO:0015405,GO:0015411,GO:0015711,GO:0015734,GO:0015849,GO:0015893,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0033283,GO:0034220,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042908,GO:0042910,GO:0043492,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0072348,GO:0098656,GO:1901682,GO:1903825	3.6.3.36	ko:K02049,ko:K10831	ko00920,ko02010,map00920,map02010	M00188,M00435	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.1,3.A.1.17.4	-	-	ABC_tran
SRD2_k127_5193698_5	1303518.CCALI_02683	1.104e-135	456.0	COG2046@1|root,COG2046@2|Bacteria	2|Bacteria	P	Belongs to the sulfate adenylyltransferase family	sat	-	2.7.1.25,2.7.7.4	ko:K00958,ko:K13811	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
SRD2_k127_5193698_18	526225.Gobs_1074	1.194e-55	202.0	COG0155@1|root,COG0155@2|Bacteria,2GJRN@201174|Actinobacteria,4ES1T@85013|Frankiales	201174|Actinobacteria	C	nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein	sir	GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016002,GO:0016053,GO:0016491,GO:0016667,GO:0016673,GO:0019344,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050311,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.7.7.1,1.8.7.1	ko:K00366,ko:K00392	ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120	M00176,M00531	R00790,R00859,R03600	RC00065,RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
SRD2_k127_5198063_9	485913.Krac_6107	7.42e-78	263.0	COG0085@1|root,COG0085@2|Bacteria,2G5VH@200795|Chloroflexi	200795|Chloroflexi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
SRD2_k127_5198063_0	525904.Tter_0709	0.0	1504.0	COG0086@1|root,COG0086@2|Bacteria,2NNPR@2323|unclassified Bacteria	2|Bacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
SRD2_k127_5198063_4	35754.JNYJ01000047_gene3527	1.36e-136	455.0	COG1404@1|root,COG1404@2|Bacteria,2IAS7@201174|Actinobacteria,4DHP7@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase S8 and S53 subtilisin kexin sedolisin	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S8
SRD2_k127_5198063_6	1380347.JNII01000007_gene730	8.672e-119	414.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4ESAW@85013|Frankiales	201174|Actinobacteria	T	PAS fold domain protein	-	-	2.7.7.65	ko:K21023	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_4
SRD2_k127_5198063_17	309801.trd_1508	1.12e-30	136.0	COG2211@1|root,COG2211@2|Bacteria,2G6UD@200795|Chloroflexi,27XXJ@189775|Thermomicrobia	189775|Thermomicrobia	G	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
SRD2_k127_5198063_3	269799.Gmet_3159	3.956e-176	583.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2WIPF@28221|Deltaproteobacteria,43T5A@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Protein of unknown function (DUF3417)	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
SRD2_k127_5198063_8	926560.KE387023_gene2478	2.594e-96	320.0	COG0346@1|root,COG1028@1|root,COG0346@2|Bacteria,COG1028@2|Bacteria,1WI3C@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	IQ	Short-chain Dehydrogenase reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SRD2_k127_5198063_7	266117.Rxyl_2617	3.74e-114	380.0	COG0809@1|root,COG0809@2|Bacteria,2GN51@201174|Actinobacteria,4CSIA@84995|Rubrobacteria	84995|Rubrobacteria	J	Queuosine biosynthesis protein	-	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
SRD2_k127_5198063_11	469383.Cwoe_1166	2.087e-62	224.0	COG2345@1|root,COG2345@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24,HTH_5
SRD2_k127_5198063_13	1321786.HMPREF1992_00421	1.331e-58	206.0	COG0048@1|root,COG0048@2|Bacteria,1V1FJ@1239|Firmicutes,4H4CG@909932|Negativicutes	909932|Negativicutes	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
SRD2_k127_5198063_14	1410665.JNKR01000013_gene1362	1.127e-55	205.0	COG0049@1|root,COG0049@2|Bacteria,1V1GG@1239|Firmicutes,4H1ZN@909932|Negativicutes	909932|Negativicutes	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
SRD2_k127_5198063_1	635013.TherJR_0293	0.0	1026.0	COG0480@1|root,COG0480@2|Bacteria,1TPF9@1239|Firmicutes,247VN@186801|Clostridia,2600F@186807|Peptococcaceae	186801|Clostridia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
SRD2_k127_5198063_2	1151116.Q7S_21035	2.019e-202	636.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,3FGD2@34037|Rahnella	1236|Gammaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
SRD2_k127_5198063_15	1121422.AUMW01000023_gene2787	1.022e-44	164.0	COG0051@1|root,COG0051@2|Bacteria,1V6C9@1239|Firmicutes,24JDC@186801|Clostridia,2620M@186807|Peptococcaceae	186801|Clostridia	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
SRD2_k127_5198063_10	555088.DealDRAFT_1523	5.511e-65	233.0	COG0087@1|root,COG0087@2|Bacteria,1TPFT@1239|Firmicutes,247NH@186801|Clostridia,42JTZ@68298|Syntrophomonadaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
SRD2_k127_5198063_12	562970.Btus_0154	2.2e-60	216.0	COG0088@1|root,COG0088@2|Bacteria,1TPGW@1239|Firmicutes,4HB01@91061|Bacilli,2789A@186823|Alicyclobacillaceae	91061|Bacilli	J	Forms part of the polypeptide exit tunnel	rplD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
SRD2_k127_5198063_18	504728.K649_09450	4.196e-21	99.0	COG0089@1|root,COG0089@2|Bacteria,1WK5N@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
SRD2_k127_5198063_5	635013.TherJR_0299	1.647e-121	396.0	COG0090@1|root,COG0090@2|Bacteria,1TP9X@1239|Firmicutes,247XY@186801|Clostridia,260NI@186807|Peptococcaceae	186801|Clostridia	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
SRD2_k127_5198063_16	370438.PTH_0324	5.252e-44	161.0	COG0185@1|root,COG0185@2|Bacteria,1V6CX@1239|Firmicutes,24JN3@186801|Clostridia,26216@186807|Peptococcaceae	186801|Clostridia	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
SRD2_k127_5198063_19	941449.dsx2_2542	4.544e-07	54.0	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,42TRE@68525|delta/epsilon subdivisions,2WQBH@28221|Deltaproteobacteria,2MBW5@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
SRD2_k127_5211102_3	521098.Aaci_2538	7.851e-19	94.0	COG0640@1|root,COG3832@1|root,COG0640@2|Bacteria,COG3832@2|Bacteria,1V599@1239|Firmicutes,4HI0G@91061|Bacilli	91061|Bacilli	K	Activator of Hsp90 ATPase 1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
SRD2_k127_5211102_0	43354.JOIJ01000002_gene4242	2.02e-60	213.0	COG0394@1|root,COG0394@2|Bacteria,2IHR3@201174|Actinobacteria,4E43G@85010|Pseudonocardiales	201174|Actinobacteria	T	Low molecular weight phosphotyrosine protein phosphatase	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
SRD2_k127_5211102_2	1408473.JHXO01000009_gene3251	3.892e-21	107.0	COG1913@1|root,COG1913@2|Bacteria,4NJFJ@976|Bacteroidetes	976|Bacteroidetes	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Reprolysin_5
SRD2_k127_5211102_4	1511.CLOST_0587	3.264e-17	95.0	COG0860@1|root,COG0860@2|Bacteria,1USZW@1239|Firmicutes,24EI9@186801|Clostridia	186801|Clostridia	MNU	non supervised orthologous group	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,GBS_Bsp-like,Glucosaminidase
SRD2_k127_5211102_1	349124.Hhal_0240	7.559e-34	134.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,1WWG5@135613|Chromatiales	135613|Chromatiales	V	pfam abc	-	-	-	ko:K09695	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC_tran
SRD2_k127_5224182_21	1229780.BN381_80233	5.596e-07	56.0	COG4658@1|root,COG4658@2|Bacteria	2|Bacteria	C	electron transport chain	-	-	1.6.5.8	ko:K00347,ko:K03614,ko:K21163	ko01059,ko01130,map01059,map01130	M00824	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Complex1_51K,NQR2_RnfD_RnfE,RnfC_N,UnbV_ASPIC,VCBS
SRD2_k127_5224182_8	215803.DB30_2436	3.045e-52	192.0	COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,42NGT@68525|delta/epsilon subdivisions,2WK3E@28221|Deltaproteobacteria,2YVIB@29|Myxococcales	28221|Deltaproteobacteria	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1875	Ham1p_like
SRD2_k127_5224182_4	335541.Swol_0453	5.385e-79	282.0	COG0689@1|root,COG0689@2|Bacteria,1TQM3@1239|Firmicutes,25E5P@186801|Clostridia,42JMQ@68298|Syntrophomonadaceae	186801|Clostridia	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56,3.6.1.66	ko:K00989,ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03016	-	-	-	Ham1p_like,RNase_PH,RNase_PH_C
SRD2_k127_5224182_13	1540221.JQNI01000002_gene2727	4.955e-31	132.0	COG0805@1|root,COG0805@2|Bacteria,1WJCW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
SRD2_k127_5224182_20	649638.Trad_1936	2.612e-10	64.0	COG1826@1|root,COG1826@2|Bacteria,1WKJH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
SRD2_k127_5224182_2	1382356.JQMP01000001_gene827	3.112e-146	476.0	COG0001@1|root,COG0001@2|Bacteria,2G67D@200795|Chloroflexi,27Y34@189775|Thermomicrobia	189775|Thermomicrobia	H	Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SRD2_k127_5224182_14	383372.Rcas_2216	1.513e-27	122.0	COG0652@1|root,COG0652@2|Bacteria,2G8IA@200795|Chloroflexi,375NH@32061|Chloroflexia	32061|Chloroflexia	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	Pro_isomerase
SRD2_k127_5224182_3	335543.Sfum_3057	2.065e-110	372.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,42N17@68525|delta/epsilon subdivisions,2WJE8@28221|Deltaproteobacteria,2MQY0@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Belongs to the ALAD family	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
SRD2_k127_5224182_12	479434.Sthe_1803	3.299e-36	153.0	COG1587@1|root,COG1587@2|Bacteria,2GBWA@200795|Chloroflexi,27Z62@189775|Thermomicrobia	189775|Thermomicrobia	H	Uroporphyrinogen-III synthase HemD	-	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
SRD2_k127_5224182_7	644966.Tmar_1261	2.346e-52	198.0	COG0181@1|root,COG0181@2|Bacteria,1TPFQ@1239|Firmicutes,2494Z@186801|Clostridia,3WCK0@538999|Clostridiales incertae sedis	186801|Clostridia	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS15760	Porphobil_deam,Porphobil_deamC
SRD2_k127_5224182_5	639030.JHVA01000001_gene315	1.446e-72	264.0	COG0373@1|root,COG0373@2|Bacteria,3Y3DQ@57723|Acidobacteria,2JHR3@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
SRD2_k127_5224182_17	1449976.KALB_4656	3.588e-17	94.0	COG5650@1|root,COG5650@2|Bacteria,2GJBC@201174|Actinobacteria,4DZJI@85010|Pseudonocardiales	201174|Actinobacteria	S	Glycosyltransferase family 87	-	-	-	ko:K13671	-	-	-	-	ko00000,ko01000,ko01003	-	GT87	-	GT87
SRD2_k127_5224182_9	391615.ABSJ01000034_gene1097	5.845e-51	192.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,1RPR7@1236|Gammaproteobacteria,1J4PY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispB	GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	iYL1228.KPN_03597,ic_1306.c3945	polyprenyl_synt
SRD2_k127_5224182_6	485913.Krac_0962	7.888e-63	242.0	COG0515@1|root,COG0515@2|Bacteria,2G8CD@200795|Chloroflexi	200795|Chloroflexi	KLT	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Pkinase
SRD2_k127_5224182_22	309801.trd_A0181	3.19e-06	57.0	COG1873@1|root,COG3798@1|root,COG1873@2|Bacteria,COG3798@2|Bacteria	2|Bacteria	O	Protein conserved in bacteria	MA20_37705	-	-	ko:K03886	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,DUF2171,MgtE_N,PRC
SRD2_k127_5224182_19	1347342.BN863_26420	1.053e-10	66.0	COG3564@1|root,COG3564@2|Bacteria,4NQEN@976|Bacteroidetes,1I2VZ@117743|Flavobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF779)	-	-	-	ko:K09959	-	-	-	-	ko00000	-	-	-	DUF779
SRD2_k127_5224182_1	357808.RoseRS_0265	2.096e-172	555.0	COG1012@1|root,COG1012@2|Bacteria,2G5JE@200795|Chloroflexi,375BH@32061|Chloroflexia	32061|Chloroflexia	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
SRD2_k127_5224182_16	525904.Tter_1129	7.301e-22	103.0	COG3415@1|root,COG3415@2|Bacteria,2NPY9@2323|unclassified Bacteria	2|Bacteria	L	Protein of unknown function (DUF3105)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013,DUF3105,HTH_Tnp_IS630
SRD2_k127_5224182_15	500153.JOEK01000014_gene5704	2.103e-24	116.0	COG1814@1|root,COG1814@2|Bacteria,2GIZ3@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
SRD2_k127_5224182_10	266117.Rxyl_0053	7.678e-47	185.0	COG0363@1|root,COG0363@2|Bacteria,2GMQ2@201174|Actinobacteria,4CQA7@84995|Rubrobacteria	84995|Rubrobacteria	G	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	-	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
SRD2_k127_5224182_18	485913.Krac_11263	2.946e-16	93.0	COG3429@1|root,COG3429@2|Bacteria,2G6ZV@200795|Chloroflexi	200795|Chloroflexi	G	Glucose-6-phosphate dehydrogenase subunit	-	-	-	-	-	-	-	-	-	-	-	-	OpcA_G6PD_assem
SRD2_k127_5224182_0	1382306.JNIM01000001_gene767	6.613e-195	620.0	COG0364@1|root,COG0364@2|Bacteria,2G5MB@200795|Chloroflexi	200795|Chloroflexi	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
SRD2_k127_5224182_11	1051632.TPY_1050	1.726e-46	169.0	COG1023@1|root,COG1023@2|Bacteria,1UHN4@1239|Firmicutes,25E7N@186801|Clostridia	186801|Clostridia	G	6-phosphogluconate dehydrogenase	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
SRD2_k127_5229853_0	525904.Tter_2711	2.296e-44	171.0	COG1573@1|root,COG1573@2|Bacteria	2|Bacteria	L	deaminated base DNA N-glycosylase activity	ung	-	3.2.2.27	ko:K03648,ko:K21929	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF4130,UDG
SRD2_k127_5229853_1	673860.AciM339_1354	3.851e-27	122.0	arCOG12220@1|root,arCOG12220@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_5231325_7	221288.JH992901_gene1080	9.642e-29	124.0	COG0451@1|root,COG0451@2|Bacteria,1GEYX@1117|Cyanobacteria	1117|Cyanobacteria	GM	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
SRD2_k127_5231325_0	1128421.JAGA01000001_gene2372	8.423e-178	565.0	COG0004@1|root,COG0004@2|Bacteria,2NQS8@2323|unclassified Bacteria	2|Bacteria	P	Ammonium Transporter Family	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	iHN637.CLJU_c42670,iYO844.BSU36510	Ammonium_transp
SRD2_k127_5231325_5	882083.SacmaDRAFT_2754	2.595e-63	228.0	COG0500@1|root,COG2226@2|Bacteria,2IP4P@201174|Actinobacteria,4E5RD@85010|Pseudonocardiales	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
SRD2_k127_5231325_3	469383.Cwoe_3478	2.245e-100	345.0	COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria	201174|Actinobacteria	Q	Belongs to the long-chain O-acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
SRD2_k127_5231325_1	1121934.AUDX01000004_gene2663	1.003e-173	562.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4FK8K@85023|Microbacteriaceae	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SRD2_k127_5231325_9	43759.JNWK01000009_gene5016	5.505e-06	56.0	COG3462@1|root,COG3462@2|Bacteria,2GRGM@201174|Actinobacteria	201174|Actinobacteria	S	membrane protein (DUF2078)	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
SRD2_k127_5231325_4	222534.KB893672_gene2971	1.867e-63	224.0	COG0500@1|root,COG0500@2|Bacteria,2GX4K@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
SRD2_k127_5231325_10	1123242.JH636434_gene5263	0.0003415	46.0	COG0050@1|root,COG0050@2|Bacteria,2IXC2@203682|Planctomycetes	203682|Planctomycetes	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
SRD2_k127_5231325_2	1242864.D187_003204	7.202e-148	478.0	COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,43EAF@68525|delta/epsilon subdivisions,2X34W@28221|Deltaproteobacteria,2YUA3@29|Myxococcales	28221|Deltaproteobacteria	S	N-terminal domain of oxidoreductase	-	-	-	ko:K07119	-	-	-	-	ko00000	-	-	-	ADH_N_2,ADH_zinc_N
SRD2_k127_5231325_6	290397.Adeh_2366	2.297e-54	201.0	COG1446@1|root,COG1446@2|Bacteria,1MWFC@1224|Proteobacteria,42NRH@68525|delta/epsilon subdivisions,2WNIB@28221|Deltaproteobacteria,2YV7G@29|Myxococcales	28221|Deltaproteobacteria	E	Asparaginase	-	-	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2
SRD2_k127_5231325_8	1146883.BLASA_1405	3.256e-14	77.0	COG2303@1|root,COG2303@2|Bacteria,2I5YA@201174|Actinobacteria,4EV87@85013|Frankiales	201174|Actinobacteria	E	GMC oxidoreductase	-	-	1.1.1.400	ko:K20927	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_2,GMC_oxred_C,GMC_oxred_N
SRD2_k127_5231409_1	4432.XP_010270365.1	7.086e-09	66.0	COG2214@1|root,KOG0691@2759|Eukaryota,37J01@33090|Viridiplantae,3GDNC@35493|Streptophyta	35493|Streptophyta	O	Chaperone protein DNAj	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ,DnaJ-X
SRD2_k127_5231409_2	1463887.KL590067_gene6227	0.0004032	51.0	2B1KK@1|root,31U22@2|Bacteria,2GTCM@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_5231409_0	485913.Krac_6502	1.997e-109	364.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Big_3_3,LTD,PKD,Pro-kuma_activ,fn3
SRD2_k127_5258309_6	1382306.JNIM01000001_gene2890	1.457e-26	124.0	COG4166@1|root,COG4166@2|Bacteria,2G5TA@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
SRD2_k127_5258309_2	1120972.AUMH01000024_gene652	3.664e-77	281.0	COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,4HARF@91061|Bacilli,279UI@186823|Alicyclobacillaceae	91061|Bacilli	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
SRD2_k127_5258309_7	760568.Desku_0493	1.921e-26	120.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia,262RV@186807|Peptococcaceae	186801|Clostridia	K	Belongs to the sigma-70 factor family. ECF subfamily	algU	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SRD2_k127_5258309_3	1392838.AWNM01000098_gene2831	1.088e-76	270.0	COG1929@1|root,COG1929@2|Bacteria,1MVG9@1224|Proteobacteria,2VK3Q@28216|Betaproteobacteria,3T2YY@506|Alcaligenaceae	28216|Betaproteobacteria	G	Belongs to the glycerate kinase type-1 family	glxK	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
SRD2_k127_5258309_0	316274.Haur_3362	1.479e-118	389.0	COG0115@1|root,COG0115@2|Bacteria,2G6AX@200795|Chloroflexi,37550@32061|Chloroflexia	32061|Chloroflexia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
SRD2_k127_5258309_4	326427.Cagg_2820	2.591e-72	276.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,2G88D@200795|Chloroflexi,374V1@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase, dimerisation and phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA_3
SRD2_k127_5258309_5	926569.ANT_06060	2.714e-32	134.0	COG1970@1|root,COG1970@2|Bacteria,2G733@200795|Chloroflexi	200795|Chloroflexi	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
SRD2_k127_5258309_1	926569.ANT_13260	1.628e-83	293.0	COG0391@1|root,COG0391@2|Bacteria,2G5MJ@200795|Chloroflexi	200795|Chloroflexi	S	Required for morphogenesis under gluconeogenic growth conditions	-	-	-	-	-	-	-	-	-	-	-	-	UPF0052
SRD2_k127_5308010_5	208439.AJAP_33070	1.242e-36	154.0	COG1277@1|root,COG1277@2|Bacteria,2IG8D@201174|Actinobacteria,4E51S@85010|Pseudonocardiales	201174|Actinobacteria	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2,ABC2_membrane_4
SRD2_k127_5308010_2	477641.MODMU_0152	9.822e-96	323.0	COG1131@1|root,COG1131@2|Bacteria,2GN8P@201174|Actinobacteria,4EV93@85013|Frankiales	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SRD2_k127_5308010_7	1449357.JQLK01000001_gene1011	8.04e-24	111.0	COG0204@1|root,COG0204@2|Bacteria,1WJXG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	PFAM Phospholipid glycerol acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
SRD2_k127_5308010_4	1121382.JQKG01000009_gene727	3.964e-50	191.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SRD2_k127_5308010_3	367299.JOEE01000001_gene1663	4.076e-93	320.0	COG2223@1|root,COG2223@2|Bacteria	2|Bacteria	P	nitrite transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SRD2_k127_5308010_0	1370120.AUWR01000008_gene528	3.121e-168	548.0	COG1070@1|root,COG1070@2|Bacteria,2GNCR@201174|Actinobacteria,23FHH@1762|Mycobacteriaceae	201174|Actinobacteria	G	FGGY family of carbohydrate kinases, N-terminal domain	-	-	2.7.1.17,2.7.1.215,2.7.1.53	ko:K00854,ko:K00862,ko:K00880	ko00040,ko00053,ko01100,map00040,map00053,map01100	M00014	R01639,R01901,R07127,R11536	RC00002,RC00017,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
SRD2_k127_5308010_1	272560.BPSS2021	1.187e-145	476.0	COG0076@1|root,COG0076@2|Bacteria,1MX25@1224|Proteobacteria,2W26D@28216|Betaproteobacteria,1KADQ@119060|Burkholderiaceae	28216|Betaproteobacteria	E	to Mus musculus sphingosine-1-phosphate lyase Sgpl1 SWALL O54955 (EMBL AF036894) (568 aa) fasta scores E()	-	-	4.1.2.27	ko:K01634	ko00600,ko01100,ko04071,map00600,map01100,map04071	M00100	R02464,R06516	RC00264,RC00721,RC01266	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
SRD2_k127_5308010_10	428126.CLOSPI_01939	0.0001034	52.0	COG1035@1|root,COG1143@1|root,COG2327@1|root,COG1035@2|Bacteria,COG1143@2|Bacteria,COG2327@2|Bacteria,1TQGA@1239|Firmicutes,3VTD6@526524|Erysipelotrichia	526524|Erysipelotrichia	C	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_7,FrhB_FdhB_C,FrhB_FdhB_N,PS_pyruv_trans
SRD2_k127_5308010_6	485913.Krac_5132	7.624e-29	127.0	COG1376@1|root,COG1376@2|Bacteria,2G6ZY@200795|Chloroflexi	200795|Chloroflexi	M	PFAM ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	LysM,YkuD
SRD2_k127_5405828_0	1282362.AEAC466_04760	6.944e-120	390.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,2KF5V@204458|Caulobacterales	204458|Caulobacterales	P	ATPase, P-type transporting, HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
SRD2_k127_5405828_1	414684.RC1_0633	1.318e-46	176.0	COG0784@1|root,COG4251@1|root,COG5278@1|root,COG0784@2|Bacteria,COG4251@2|Bacteria,COG5278@2|Bacteria,1NC9X@1224|Proteobacteria,2TYBZ@28211|Alphaproteobacteria,2JYXR@204441|Rhodospirillales	204441|Rhodospirillales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg
SRD2_k127_5424971_3	326424.FRAAL1786	1.872e-05	47.0	2EPBK@1|root,33BM6@2|Bacteria,2GWT5@201174|Actinobacteria,4EWPZ@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_5424971_0	1306174.JODP01000027_gene82	2.509e-83	284.0	2DKWW@1|root,30NAT@2|Bacteria,2GKYJ@201174|Actinobacteria	201174|Actinobacteria	S	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_4,HTH_Tnp_4
SRD2_k127_5424971_1	103733.JNYO01000045_gene6200	1.388e-75	258.0	COG2801@1|root,COG2801@2|Bacteria,2GJ3V@201174|Actinobacteria,4E4EZ@85010|Pseudonocardiales	201174|Actinobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,LZ_Tnp_IS481,rve,rve_3
SRD2_k127_5424971_2	1194972.MVAC_28583	4.233e-16	82.0	COG0179@1|root,COG0179@2|Bacteria,2GMSJ@201174|Actinobacteria,23EX4@1762|Mycobacteriaceae	201174|Actinobacteria	Q	fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
SRD2_k127_5426735_23	1284352.AOIG01000006_gene2692	6.887e-21	102.0	COG4166@1|root,COG4166@2|Bacteria,1TNYQ@1239|Firmicutes,4HAMK@91061|Bacilli,26QGU@186822|Paenibacillaceae	91061|Bacilli	E	ABC transporter substrate-binding protein	oppA	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
SRD2_k127_5426735_13	644966.Tmar_0288	7.288e-72	254.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,3WD0N@538999|Clostridiales incertae sedis	186801|Clostridia	U	ABC transporter (Permease)	oppB	-	-	ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
SRD2_k127_5426735_11	867903.ThesuDRAFT_01162	8.158e-79	273.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,3WD2P@538999|Clostridiales incertae sedis	186801|Clostridia	EP	N-terminal TM domain of oligopeptide transport permease C	oppC	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
SRD2_k127_5426735_6	926550.CLDAP_11120	2.614e-119	393.0	COG0444@1|root,COG0444@2|Bacteria,2G61B@200795|Chloroflexi	200795|Chloroflexi	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
SRD2_k127_5426735_5	324602.Caur_2260	1.807e-126	416.0	COG4608@1|root,COG4608@2|Bacteria,2G5R5@200795|Chloroflexi,3754I@32061|Chloroflexia	32061|Chloroflexia	P	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	-	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
SRD2_k127_5426735_10	1120973.AQXL01000133_gene1721	1.041e-80	286.0	COG1960@1|root,COG1960@2|Bacteria,1TR1Y@1239|Firmicutes,4HC1N@91061|Bacilli,279IR@186823|Alicyclobacillaceae	91061|Bacilli	C	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	ko:K06446	ko00930,ko01100,ko01120,map00930,map01100,map01120	-	R06943	RC00052	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SRD2_k127_5426735_3	1121472.AQWN01000007_gene1053	1.159e-133	432.0	COG0214@1|root,COG0214@2|Bacteria,1TPSZ@1239|Firmicutes,248C1@186801|Clostridia,25ZYC@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
SRD2_k127_5426735_14	351607.Acel_1347	4.667e-63	222.0	COG0311@1|root,COG0311@2|Bacteria,2GNYG@201174|Actinobacteria,4ESCW@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
SRD2_k127_5426735_2	309801.trd_0202	1.084e-157	519.0	COG3854@1|root,COG3854@2|Bacteria,2G5P5@200795|Chloroflexi,27Y49@189775|Thermomicrobia	189775|Thermomicrobia	S	R3H domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA,R3H
SRD2_k127_5426735_17	1089553.Tph_c28790	4.31e-46	174.0	COG0125@1|root,COG0125@2|Bacteria,1V1HE@1239|Firmicutes,24HHC@186801|Clostridia,42GBY@68295|Thermoanaerobacterales	186801|Clostridia	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
SRD2_k127_5426735_21	644966.Tmar_0079	1.484e-23	110.0	COG3870@1|root,COG3870@2|Bacteria,1V6NI@1239|Firmicutes,24N37@186801|Clostridia,3WDCC@538999|Clostridiales incertae sedis	186801|Clostridia	S	Cyclic-di-AMP receptor	yaaQ	-	-	-	-	-	-	-	-	-	-	-	CdAMP_rec
SRD2_k127_5426735_8	309801.trd_0701	3.743e-109	365.0	COG0714@1|root,COG0714@2|Bacteria,2G66D@200795|Chloroflexi,27XT7@189775|Thermomicrobia	189775|Thermomicrobia	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
SRD2_k127_5426735_16	479434.Sthe_1589	2.64e-46	183.0	COG1721@1|root,COG1721@2|Bacteria,2G5XH@200795|Chloroflexi,27XZ3@189775|Thermomicrobia	189775|Thermomicrobia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
SRD2_k127_5426735_19	292459.STH2555	2.655e-36	160.0	COG1305@1|root,COG1305@2|Bacteria,1TP8K@1239|Firmicutes,24CZV@186801|Clostridia	186801|Clostridia	E	Transglutaminase-like	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129,Transglut_core
SRD2_k127_5426735_24	1122611.KB904014_gene6793	6.587e-20	103.0	COG1234@1|root,COG1234@2|Bacteria,2IQCE@201174|Actinobacteria	201174|Actinobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
SRD2_k127_5426735_12	100226.SCO0668	3.492e-75	271.0	COG0277@1|root,COG0277@2|Bacteria,2GIS6@201174|Actinobacteria	201174|Actinobacteria	C	FAD linked	eapA	-	2.5.1.26	ko:K00803	ko00565,ko01100,ko04146,map00565,map01100,map04146	-	R04311	RC00020,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
SRD2_k127_5426735_9	316067.Geob_2508	9.247e-84	288.0	COG0709@1|root,COG0709@2|Bacteria,1MWFG@1224|Proteobacteria,42MC3@68525|delta/epsilon subdivisions,2WK3M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
SRD2_k127_5426735_20	309801.trd_1752	1.227e-28	127.0	COG1595@1|root,COG1595@2|Bacteria,2G6MG@200795|Chloroflexi,27YI4@189775|Thermomicrobia	189775|Thermomicrobia	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SRD2_k127_5426735_29	85643.Tmz1t_1921	0.0006991	51.0	COG5662@1|root,COG5662@2|Bacteria,1QE87@1224|Proteobacteria,2WAJV@28216|Betaproteobacteria,2KZNK@206389|Rhodocyclales	206389|Rhodocyclales	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_5426735_15	525904.Tter_0756	4.036e-48	190.0	COG1595@1|root,COG1595@2|Bacteria,2NPHU@2323|unclassified Bacteria	2|Bacteria	K	RNA polymerase sigma factor	sigH	GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SRD2_k127_5426735_27	479434.Sthe_1241	1.808e-09	67.0	COG5662@1|root,COG5662@2|Bacteria,2GA5X@200795|Chloroflexi,27ZCC@189775|Thermomicrobia	189775|Thermomicrobia	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
SRD2_k127_5426735_25	246969.TAM4_1472	1.019e-11	76.0	COG0454@1|root,arCOG00845@2157|Archaea,2Y67B@28890|Euryarchaeota,2430F@183968|Thermococci	183968|Thermococci	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SRD2_k127_5426735_7	330214.NIDE3049	1.375e-112	381.0	COG1078@1|root,COG1078@2|Bacteria,3J0YB@40117|Nitrospirae	40117|Nitrospirae	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
SRD2_k127_5426735_18	671143.DAMO_2602	2.485e-44	173.0	COG0584@1|root,COG0584@2|Bacteria,2NPNS@2323|unclassified Bacteria	2|Bacteria	C	PFAM Glycerophosphoryl diester phosphodiesterase	glpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
SRD2_k127_5426735_22	525904.Tter_0505	3.835e-23	117.0	COG0265@1|root,COG0695@1|root,COG0265@2|Bacteria,COG0695@2|Bacteria,2NQ8T@2323|unclassified Bacteria	2|Bacteria	O	Glutaredoxin	grxC	-	3.4.21.107	ko:K03676,ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	Glutaredoxin,PDZ_2
SRD2_k127_5426735_4	1382306.JNIM01000001_gene663	5.02e-132	450.0	COG2366@1|root,COG2366@2|Bacteria,2G63N@200795|Chloroflexi	200795|Chloroflexi	S	PFAM peptidase S45 penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
SRD2_k127_5426735_0	235985.BBPN01000040_gene354	8.07e-167	542.0	COG3511@1|root,COG3511@2|Bacteria,2GKPN@201174|Actinobacteria,2NKRD@228398|Streptacidiphilus	201174|Actinobacteria	M	Phosphoesterase family	-	-	3.1.4.3	ko:K01114	ko00562,ko00564,ko00565,ko01100,ko01110,ko02024,ko04919,map00562,map00564,map00565,map01100,map01110,map02024,map04919	-	R01312,R02027,R02052,R03332,R07381	RC00017,RC00425	ko00000,ko00001,ko01000,ko02042	-	-	-	Phosphoesterase
SRD2_k127_5426735_26	485913.Krac_8941	1.683e-10	68.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	DUF2087,HTH_20,HTH_5
SRD2_k127_5426735_1	255470.cbdbA943	1.453e-165	526.0	COG1260@1|root,COG1260@2|Bacteria,2G5YH@200795|Chloroflexi,34CJX@301297|Dehalococcoidia	301297|Dehalococcoidia	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
SRD2_k127_5513975_6	555088.DealDRAFT_1051	1.984e-84	285.0	COG0740@1|root,COG0740@2|Bacteria,1TQ91@1239|Firmicutes,247QY@186801|Clostridia,42JMV@68298|Syntrophomonadaceae	186801|Clostridia	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
SRD2_k127_5513975_7	644966.Tmar_2227	2.676e-69	254.0	COG0544@1|root,COG0544@2|Bacteria,1TQQ8@1239|Firmicutes,248C3@186801|Clostridia,3WCGE@538999|Clostridiales incertae sedis	186801|Clostridia	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
SRD2_k127_5513975_11	1190606.AJYG01000064_gene1451	2.767e-07	63.0	COG3764@1|root,COG3764@2|Bacteria,1P806@1224|Proteobacteria,1S9RI@1236|Gammaproteobacteria,1Y0RV@135623|Vibrionales	135623|Vibrionales	M	Sortase family	-	-	-	-	-	-	-	-	-	-	-	-	Sortase
SRD2_k127_5513975_5	1120950.KB892707_gene4680	3.438e-90	309.0	COG0846@1|root,COG0846@2|Bacteria,2GJI3@201174|Actinobacteria,4DWS0@85009|Propionibacteriales	201174|Actinobacteria	K	Sir2 family	cobB2	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
SRD2_k127_5513975_10	1382306.JNIM01000001_gene2482	9.621e-46	177.0	COG3662@1|root,COG3662@2|Bacteria,2G8VS@200795|Chloroflexi	200795|Chloroflexi	S	Uncharacterized protein conserved in bacteria (DUF2236)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2236
SRD2_k127_5513975_9	1120949.KB903294_gene3831	3.559e-60	220.0	COG0726@1|root,COG0726@2|Bacteria,2HFKX@201174|Actinobacteria,4D906@85008|Micromonosporales	201174|Actinobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
SRD2_k127_5513975_4	1122603.ATVI01000008_gene2315	6.508e-97	331.0	COG1024@1|root,COG1024@2|Bacteria,1NDT7@1224|Proteobacteria,1RSCI@1236|Gammaproteobacteria,1X4E8@135614|Xanthomonadales	135614|Xanthomonadales	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
SRD2_k127_5513975_0	1123023.JIAI01000005_gene917	1.013e-286	900.0	COG0466@1|root,COG0466@2|Bacteria,2GK9D@201174|Actinobacteria,4DYVW@85010|Pseudonocardiales	201174|Actinobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
SRD2_k127_5513975_8	710696.Intca_0155	1.782e-67	244.0	COG0726@1|root,COG0726@2|Bacteria,2HEQK@201174|Actinobacteria,4FHJZ@85021|Intrasporangiaceae	201174|Actinobacteria	G	Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Glycos_transf_2,Polysacc_deac_1
SRD2_k127_5513975_3	365528.KB891215_gene2603	3.013e-106	356.0	COG0667@1|root,COG0667@2|Bacteria,2GJ6R@201174|Actinobacteria,4ES41@85013|Frankiales	201174|Actinobacteria	C	aldo keto reductase	-	-	1.1.1.65	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120	-	R01708	RC00116	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
SRD2_k127_5513975_2	28444.JODQ01000006_gene662	2.01e-107	363.0	COG1533@1|root,COG1533@2|Bacteria,2GM31@201174|Actinobacteria,4EFX2@85012|Streptosporangiales	201174|Actinobacteria	L	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SRD2_k127_5513975_1	1120949.KB903350_gene8254	1.875e-135	449.0	COG2256@1|root,COG2256@2|Bacteria,2GKDP@201174|Actinobacteria,4D9FJ@85008|Micromonosporales	201174|Actinobacteria	L	ATPase related to the helicase subunit of the Holliday junction resolvase	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
SRD2_k127_5513975_12	1266909.AUAG01000021_gene362	0.0001259	48.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3,PAS_9
SRD2_k127_5514072_1	479434.Sthe_1241	6.253e-09	60.0	COG5662@1|root,COG5662@2|Bacteria,2GA5X@200795|Chloroflexi,27ZCC@189775|Thermomicrobia	189775|Thermomicrobia	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
SRD2_k127_5514072_0	525904.Tter_0756	6.452e-50	188.0	COG1595@1|root,COG1595@2|Bacteria,2NPHU@2323|unclassified Bacteria	2|Bacteria	K	RNA polymerase sigma factor	sigH	GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SRD2_k127_56905_1	471853.Bcav_4021	2.169e-26	111.0	COG1937@1|root,COG1937@2|Bacteria,2IQAC@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in bacteria	csoR	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
SRD2_k127_56905_0	1121372.AULK01000001_gene1856	3.005e-71	247.0	COG0701@1|root,COG3350@1|root,COG0701@2|Bacteria,COG3350@2|Bacteria,2GJWR@201174|Actinobacteria	201174|Actinobacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
SRD2_k127_594401_0	1206731.BAGB01000023_gene1222	3.705e-165	532.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4G5I0@85025|Nocardiaceae	201174|Actinobacteria	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SRD2_k127_594401_1	485913.Krac_0962	1.426e-63	239.0	COG0515@1|root,COG0515@2|Bacteria,2G8CD@200795|Chloroflexi	200795|Chloroflexi	KLT	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Pkinase
SRD2_k127_594401_2	765420.OSCT_1526	7.325e-38	149.0	COG2085@1|root,COG2085@2|Bacteria,2G900@200795|Chloroflexi,37616@32061|Chloroflexia	32061|Chloroflexia	C	NAD binding domain of 6-phosphogluconate dehydrogenase	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
SRD2_k127_594401_3	710111.FraQA3DRAFT_4767	6.387e-26	112.0	COG1846@1|root,COG1846@2|Bacteria,2IFQ9@201174|Actinobacteria,4ET3M@85013|Frankiales	201174|Actinobacteria	K	PFAM regulatory protein, MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
SRD2_k127_594401_4	1521187.JPIM01000132_gene1338	2.164e-07	56.0	COG0477@1|root,COG2814@2|Bacteria,2G6D7@200795|Chloroflexi,3763C@32061|Chloroflexia	32061|Chloroflexia	EGP	major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
SRD2_k127_595679_4	886293.Sinac_1136	1.044e-15	82.0	COG0500@1|root,COG2226@2|Bacteria,2J1GI@203682|Planctomycetes	203682|Planctomycetes	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
SRD2_k127_595679_1	929712.KI912613_gene3508	2.365e-45	181.0	COG2519@1|root,COG2519@2|Bacteria	2|Bacteria	J	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_tranf_2_3,Glyco_trans_1_2,Glycos_transf_2,Methyltransf_23,Methyltransf_25,RgpF
SRD2_k127_595679_3	1227352.C173_08541	7.474e-16	89.0	COG0110@1|root,COG0110@2|Bacteria	2|Bacteria	S	O-acyltransferase activity	wbbJ	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008374,GO:0016740,GO:0016746,GO:0016747,GO:0044424,GO:0044444,GO:0044464	-	ko:K08280,ko:K18234	-	-	-	-	ko00000,ko01000,ko01005,ko01504	-	-	-	Glycos_transf_2,Hexapep,Hexapep_2
SRD2_k127_595679_5	1392493.JIAB01000001_gene1741	2.816e-14	83.0	COG0110@1|root,COG0110@2|Bacteria,1VFFY@1239|Firmicutes,24XAW@186801|Clostridia	186801|Clostridia	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
SRD2_k127_595679_2	391037.Sare_0212	7.385e-20	104.0	COG1835@1|root,COG1835@2|Bacteria,2GP6W@201174|Actinobacteria,4DM2A@85008|Micromonosporales	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
SRD2_k127_595679_0	929712.KI912613_gene3528	1.692e-51	189.0	COG0500@1|root,COG2226@2|Bacteria,2HAB1@201174|Actinobacteria	2|Bacteria	Q	Methyltransferase domain	-	-	-	ko:K16648	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	Methyltransf_11
SRD2_k127_6024329_0	1122138.AQUZ01000011_gene4922	6.461e-98	336.0	COG1835@1|root,COG1835@2|Bacteria,2GKUS@201174|Actinobacteria,4DS4D@85009|Propionibacteriales	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
SRD2_k127_6024329_3	661478.OP10G_2055	3.094e-36	145.0	29KMP@1|root,307IZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4287
SRD2_k127_6024329_1	1120948.KB903247_gene4496	3.445e-65	228.0	COG4430@1|root,COG4430@2|Bacteria,2II0D@201174|Actinobacteria,4E47X@85010|Pseudonocardiales	201174|Actinobacteria	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
SRD2_k127_6024329_2	446470.Snas_2885	2.489e-42	162.0	COG0237@1|root,COG0237@2|Bacteria,2IIS6@201174|Actinobacteria,4EZY7@85014|Glycomycetales	201174|Actinobacteria	H	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_18
SRD2_k127_6028549_0	760568.Desku_2698	9.814e-123	407.0	COG4962@1|root,COG4962@2|Bacteria,1TQ0Z@1239|Firmicutes,249VS@186801|Clostridia,2612R@186807|Peptococcaceae	186801|Clostridia	U	type II secretion system protein E	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
SRD2_k127_6028549_1	1192868.CAIU01000021_gene2997	5.957e-10	70.0	COG4965@1|root,COG4965@2|Bacteria,1MUXK@1224|Proteobacteria,2TRBI@28211|Alphaproteobacteria,43HGU@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	U	Pilus assembly protein	tadB	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
SRD2_k127_6028549_3	868595.Desca_1184	0.0005212	51.0	COG2064@1|root,COG2064@2|Bacteria,1V2T1@1239|Firmicutes,24GQ4@186801|Clostridia,261D6@186807|Peptococcaceae	186801|Clostridia	NU	PFAM type II secretion system	tadC	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
SRD2_k127_6028549_2	1191299.AJYX01000064_gene3580	0.0002636	51.0	COG4961@1|root,COG4961@2|Bacteria,1NCGE@1224|Proteobacteria,1SDQ1@1236|Gammaproteobacteria,1XXZS@135623|Vibrionales	135623|Vibrionales	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
SRD2_k127_6039714_15	443218.AS9A_2146	8.977e-49	186.0	2CAJE@1|root,33XCP@2|Bacteria,2IMDF@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_6039714_9	1206732.BAGD01000020_gene298	2.654e-63	220.0	COG5649@1|root,COG5649@2|Bacteria,2IHVG@201174|Actinobacteria,4G1W6@85025|Nocardiaceae	201174|Actinobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
SRD2_k127_6039714_23	926560.KE387027_gene945	1.692e-06	57.0	COG2137@1|root,COG2137@2|Bacteria,1WKKC@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Modulates RecA activity	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
SRD2_k127_6039714_3	500635.MITSMUL_05406	4.036e-151	487.0	COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,4H2TB@909932|Negativicutes	909932|Negativicutes	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
SRD2_k127_6039714_18	742818.HMPREF9451_00590	9.1e-31	134.0	COG0558@1|root,COG1546@1|root,COG0558@2|Bacteria,COG1546@2|Bacteria,2IQ8T@201174|Actinobacteria,4CYG4@84998|Coriobacteriia	84998|Coriobacteriia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	cinA	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf,CinA
SRD2_k127_6039714_17	1329516.JPST01000006_gene1611	2.257e-38	150.0	COG0558@1|root,COG0558@2|Bacteria,1V6PJ@1239|Firmicutes,4HCEX@91061|Bacilli,27BAJ@186824|Thermoactinomycetaceae	91061|Bacilli	I	CDP-alcohol phosphatidyltransferase	pgsA	GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS06365	CDP-OH_P_transf
SRD2_k127_6039714_16	1382304.JNIL01000001_gene540	3.619e-41	168.0	COG1666@1|root,COG1666@2|Bacteria,1V3UR@1239|Firmicutes,4HHVD@91061|Bacilli,278D5@186823|Alicyclobacillaceae	91061|Bacilli	S	Belongs to the UPF0234 family	yitK	-	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
SRD2_k127_6039714_20	429009.Adeg_1943	4.402e-22	106.0	COG1426@1|root,COG1426@2|Bacteria,1V1N7@1239|Firmicutes,24M2Q@186801|Clostridia,42J4X@68295|Thermoanaerobacterales	186801|Clostridia	S	Domain of unknown function (DUF4115)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4115,HTH_25
SRD2_k127_6039714_4	867845.KI911784_gene1368	1.887e-147	496.0	COG1674@1|root,COG1674@2|Bacteria,2G5XC@200795|Chloroflexi,3753X@32061|Chloroflexia	32061|Chloroflexia	D	PFAM cell divisionFtsK SpoIIIE	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
SRD2_k127_6039714_1	1121422.AUMW01000003_gene927	2.901e-194	625.0	COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,2488J@186801|Clostridia,2601W@186807|Peptococcaceae	186801|Clostridia	J	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
SRD2_k127_6039714_11	309801.trd_0206	1.827e-59	216.0	COG1573@1|root,COG1573@2|Bacteria,2G6BR@200795|Chloroflexi,27XM8@189775|Thermomicrobia	189775|Thermomicrobia	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
SRD2_k127_6039714_6	264732.Moth_1068	2.383e-87	302.0	COG0329@1|root,COG0329@2|Bacteria,1TPCK@1239|Firmicutes,247T5@186801|Clostridia,42FSY@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
SRD2_k127_6039714_5	941449.dsx2_2593	3.619e-94	329.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,42MDM@68525|delta/epsilon subdivisions,2WJ5Y@28221|Deltaproteobacteria,2M9IV@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
SRD2_k127_6039714_14	498761.HM1_2327	4.467e-52	193.0	COG0289@1|root,COG0289@2|Bacteria,1TR9D@1239|Firmicutes,248FY@186801|Clostridia	186801|Clostridia	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
SRD2_k127_6039714_0	1089553.Tph_c11370	3.723e-252	802.0	COG1185@1|root,COG1185@2|Bacteria,1TQDW@1239|Firmicutes,248RW@186801|Clostridia,42F53@68295|Thermoanaerobacterales	186801|Clostridia	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
SRD2_k127_6039714_19	866776.HMPREF9321_0218	2.958e-30	122.0	COG0184@1|root,COG0184@2|Bacteria,1VA5C@1239|Firmicutes,4H55W@909932|Negativicutes	909932|Negativicutes	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
SRD2_k127_6039714_10	502025.Hoch_2148	1.613e-61	223.0	COG1597@1|root,COG1597@2|Bacteria,1RCJT@1224|Proteobacteria,42W6W@68525|delta/epsilon subdivisions,2X6V3@28221|Deltaproteobacteria,2YUYD@29|Myxococcales	28221|Deltaproteobacteria	I	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
SRD2_k127_6039714_8	357808.RoseRS_3756	8.97e-71	255.0	COG0196@1|root,COG0196@2|Bacteria,2G6JF@200795|Chloroflexi,374TG@32061|Chloroflexia	32061|Chloroflexia	H	TIGRFAM riboflavin biosynthesis protein RibF	-	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
SRD2_k127_6039714_13	1128421.JAGA01000003_gene3155	4.196e-56	214.0	COG0130@1|root,COG0130@2|Bacteria,2NP9J@2323|unclassified Bacteria	2|Bacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C,TruB_C_2,TruB_N
SRD2_k127_6039714_12	1089553.Tph_c11330	1.719e-56	209.0	COG0618@1|root,COG0618@2|Bacteria,1TPXX@1239|Firmicutes,248R3@186801|Clostridia,42ER4@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM phosphoesterase, RecJ domain protein	nrnA	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
SRD2_k127_6039714_22	867903.ThesuDRAFT_00232	9.167e-18	95.0	COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,24MPB@186801|Clostridia,3WDII@538999|Clostridiales incertae sedis	186801|Clostridia	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
SRD2_k127_6039714_2	246194.CHY_1766	2.252e-192	620.0	COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,248SJ@186801|Clostridia,42EP2@68295|Thermoanaerobacterales	186801|Clostridia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
SRD2_k127_6039714_21	357808.RoseRS_3750	4.897e-20	98.0	COG2740@1|root,COG2740@2|Bacteria,2G72H@200795|Chloroflexi,375YN@32061|Chloroflexia	32061|Chloroflexia	K	Protein of unknown function (DUF448)	-	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448
SRD2_k127_6039714_7	373903.Hore_07820	1.898e-74	259.0	COG0195@1|root,COG0195@2|Bacteria,1TPB3@1239|Firmicutes,247W8@186801|Clostridia,3WAGQ@53433|Halanaerobiales	186801|Clostridia	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
SRD2_k127_6042098_0	292459.STH2116	4.022e-153	490.0	COG0065@1|root,COG0065@2|Bacteria,1TPE5@1239|Firmicutes,2484F@186801|Clostridia	186801|Clostridia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
SRD2_k127_6042098_2	292459.STH2115	1.607e-69	242.0	COG0066@1|root,COG0066@2|Bacteria,1V1I6@1239|Firmicutes,24FUI@186801|Clostridia	186801|Clostridia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
SRD2_k127_6042098_1	1218173.BALCAV_0206130	4.567e-88	310.0	COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,4HATP@91061|Bacilli,1ZB3Y@1386|Bacillus	91061|Bacilli	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU28270	Iso_dh
SRD2_k127_6045545_2	1265310.CCBD010000063_gene1175	1.133e-32	144.0	COG2114@1|root,COG2267@1|root,COG2114@2|Bacteria,COG2267@2|Bacteria,2IASU@201174|Actinobacteria,232Z7@1762|Mycobacteriaceae	201174|Actinobacteria	IT	PFAM Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Guanylate_cyc
SRD2_k127_6045545_3	1380347.JNII01000006_gene1414	8.921e-20	104.0	COG4585@1|root,COG4585@2|Bacteria,2HDZV@201174|Actinobacteria,4EUIQ@85013|Frankiales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
SRD2_k127_6045545_0	368407.Memar_1131	1.24e-42	166.0	COG3832@1|root,arCOG05261@2157|Archaea	2157|Archaea	H	Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
SRD2_k127_6045545_1	935836.JAEL01000145_gene3216	1.672e-36	139.0	COG0640@1|root,COG0640@2|Bacteria,1VAMP@1239|Firmicutes,4HNAJ@91061|Bacilli,1ZGEP@1386|Bacillus	91061|Bacilli	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
SRD2_k127_6054042_2	926561.KB900622_gene690	5.213e-81	295.0	COG0849@1|root,COG0849@2|Bacteria,1UD79@1239|Firmicutes,25HUK@186801|Clostridia,3WBK1@53433|Halanaerobiales	186801|Clostridia	D	Cell division protein FtsA	-	-	-	-	-	-	-	-	-	-	-	-	FtsA
SRD2_k127_6054042_0	1121921.KB898707_gene1279	5.878e-196	641.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,2PMKI@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	J	Threonyl and Alanyl tRNA synthetase second additional domain	alaS	GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833,iJN746.PP_4474	DHHA1,tRNA-synt_2c,tRNA_SAD
SRD2_k127_6054042_3	742722.HMPREF9463_01497	2.183e-70	248.0	COG1191@1|root,COG1191@2|Bacteria,2GKSY@201174|Actinobacteria,4CUM2@84998|Coriobacteriia	84998|Coriobacteriia	K	RNA polymerase sigma-70 factor, sigma-B F G subfamily	-	-	-	ko:K03090	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
SRD2_k127_6054042_6	266940.Krad_3792	2.614e-05	54.0	COG2172@1|root,COG2172@2|Bacteria	2|Bacteria	T	sigma factor antagonist activity	rshA	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
SRD2_k127_6054042_5	485913.Krac_1311	2.808e-29	130.0	COG1295@1|root,COG1295@2|Bacteria,2G7DE@200795|Chloroflexi	200795|Chloroflexi	S	PFAM ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
SRD2_k127_6054042_1	1125863.JAFN01000001_gene2870	1.181e-195	632.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,42NC6@68525|delta/epsilon subdivisions,2WJEV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
SRD2_k127_6054042_4	999423.HMPREF9161_00546	2.551e-66	235.0	COG0124@1|root,COG0124@2|Bacteria,1TP3D@1239|Firmicutes,4H20Q@909932|Negativicutes	909932|Negativicutes	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
SRD2_k127_6056761_3	269800.Tfu_2701	2.424e-35	145.0	COG0755@1|root,COG0755@2|Bacteria,2GJR1@201174|Actinobacteria,4EGM5@85012|Streptosporangiales	201174|Actinobacteria	O	Cytochrome C assembly protein	ccsB	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
SRD2_k127_6056761_4	219305.MCAG_01107	4.745e-18	89.0	COG0346@1|root,COG0346@2|Bacteria,2GRN1@201174|Actinobacteria,4DG9T@85008|Micromonosporales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SRD2_k127_6056761_5	1111729.ATYV01000019_gene274	5.092e-10	67.0	COG1846@1|root,COG1846@2|Bacteria,2GMV1@201174|Actinobacteria,22MJA@1653|Corynebacteriaceae	201174|Actinobacteria	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
SRD2_k127_6056761_2	1123065.ATWL01000004_gene2912	6.662e-40	163.0	COG0683@1|root,COG0683@2|Bacteria,2GM00@201174|Actinobacteria	201174|Actinobacteria	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
SRD2_k127_6056761_1	383372.Rcas_1680	7.004e-57	211.0	COG2064@1|root,COG2064@2|Bacteria,2G6CF@200795|Chloroflexi,3766N@32061|Chloroflexia	32061|Chloroflexia	NU	PFAM type II secretion system protein	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
SRD2_k127_6056761_0	1120985.AUMI01000014_gene1067	2.348e-59	217.0	COG4965@1|root,COG4965@2|Bacteria,1UZ3V@1239|Firmicutes,4H3YR@909932|Negativicutes	909932|Negativicutes	U	Type II secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
SRD2_k127_6056761_6	1382303.JPOM01000001_gene158	7.272e-06	54.0	COG3745@1|root,COG3745@2|Bacteria,1MW75@1224|Proteobacteria,2TTPE@28211|Alphaproteobacteria,2KGHB@204458|Caulobacterales	204458|Caulobacterales	U	Flp pilus assembly protein CpaB	cpaB	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
SRD2_k127_6072547_1	2002.JOEQ01000033_gene1694	7.047e-111	367.0	COG0715@1|root,COG0715@2|Bacteria,2GK7X@201174|Actinobacteria,4EI7Q@85012|Streptosporangiales	201174|Actinobacteria	P	NMT1-like family	ssuA3	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
SRD2_k127_6072547_3	1120949.KB903310_gene923	1.487e-83	285.0	COG0600@1|root,COG0600@2|Bacteria,2GIWG@201174|Actinobacteria,4D9BV@85008|Micromonosporales	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	ssuC3	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
SRD2_k127_6072547_0	42256.RradSPS_0427	3.532e-219	692.0	COG1884@1|root,COG1884@2|Bacteria,2GM65@201174|Actinobacteria,4CPEB@84995|Rubrobacteria	84995|Rubrobacteria	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
SRD2_k127_6072547_2	888060.HMPREF9081_0051	1.131e-90	308.0	COG1703@1|root,COG1703@2|Bacteria,1TQT4@1239|Firmicutes,4H1WI@909932|Negativicutes	909932|Negativicutes	E	LAO AO transport system	argK	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
SRD2_k127_6072547_5	525904.Tter_1433	1.186e-43	179.0	COG1316@1|root,COG1316@2|Bacteria	2|Bacteria	K	TRANSCRIPTIONal	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
SRD2_k127_6072547_4	485913.Krac_11240	6.801e-54	191.0	COG1960@1|root,COG1960@2|Bacteria,2G5K3@200795|Chloroflexi	200795|Chloroflexi	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SRD2_k127_6098345_0	443144.GM21_0579	2.063e-114	374.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,42N1H@68525|delta/epsilon subdivisions,2WJ0R@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
SRD2_k127_6098345_3	1382356.JQMP01000004_gene221	1.961e-05	53.0	COG4283@1|root,COG4283@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1706)	M1-431	-	-	-	-	-	-	-	-	-	-	-	DUF1706
SRD2_k127_6098345_4	345341.KUTG_02419	4.892e-05	54.0	COG3850@1|root,COG3850@2|Bacteria,2GIWI@201174|Actinobacteria,4E0TS@85010|Pseudonocardiales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2
SRD2_k127_6098345_2	273063.STK_20800	2.324e-08	65.0	COG4353@1|root,arCOG01699@2157|Archaea,2XR1F@28889|Crenarchaeota	28889|Crenarchaeota	S	uncharacterised conserved protein UCP017998	-	-	-	-	-	-	-	-	-	-	-	-	DUF1122
SRD2_k127_6098345_1	1172188.KB911824_gene3399	2.12e-82	301.0	28JU0@1|root,2Z9J3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_6103819_2	1173263.Syn7502_01430	2.497e-16	89.0	COG0758@1|root,COG0758@2|Bacteria,1GPU0@1117|Cyanobacteria,1H3VJ@1129|Synechococcus	1117|Cyanobacteria	LU	Protein of unknown function (DUF2493)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2493
SRD2_k127_6103819_0	1462527.CCDM010000009_gene379	1.178e-92	308.0	COG0605@1|root,COG0605@2|Bacteria,1TPXT@1239|Firmicutes,4HA6U@91061|Bacilli,23JA5@182709|Oceanobacillus	91061|Bacilli	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodA	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
SRD2_k127_6103819_3	371731.Rsw2DRAFT_0714	1.048e-12	80.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2TRFZ@28211|Alphaproteobacteria,1FB37@1060|Rhodobacter	28211|Alphaproteobacteria	K	TIGRFAM phosphate regulon transcriptional regulatory protein PhoB	phoB	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SRD2_k127_6103819_1	365528.KB891245_gene6441	4.223e-58	210.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,4ESA4@85013|Frankiales	201174|Actinobacteria	J	Belongs to the amidase family	amiA2	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	iNJ661.Rv2363	Amidase
SRD2_k127_6108239_2	47763.JNZA01000036_gene2469	5.968e-07	56.0	COG2197@1|root,COG2197@2|Bacteria,2GJG4@201174|Actinobacteria	201174|Actinobacteria	T	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
SRD2_k127_6108239_1	502025.Hoch_4802	5.705e-25	114.0	29HWC@1|root,304TF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
SRD2_k127_6108239_0	1242864.D187_008994	1.555e-71	246.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,2YUBZ@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdA1	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
SRD2_k127_6121376_1	240292.Ava_2978	3.17e-15	89.0	COG1807@1|root,COG1807@2|Bacteria,1GCAK@1117|Cyanobacteria	1117|Cyanobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
SRD2_k127_6121376_0	525904.Tter_1665	4.947e-161	520.0	COG0442@1|root,COG0442@2|Bacteria,2NNKF@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017101,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
SRD2_k127_6165407_7	468059.AUHA01000004_gene2241	1.437e-24	111.0	COG4770@1|root,COG4770@2|Bacteria,4NM1W@976|Bacteroidetes,1IPSQ@117747|Sphingobacteriia	976|Bacteroidetes	I	TIGRFAM acetyl-CoA carboxylase, biotin carboxylase	-	-	6.3.4.14,6.4.1.2,6.4.1.3,6.4.1.4	ko:K01961,ko:K01965,ko:K01968	ko00061,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00036,M00082,M00373,M00376,M00741	R00742,R01859,R04138,R04385	RC00040,RC00097,RC00253,RC00367,RC00609,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
SRD2_k127_6165407_1	1220534.B655_0692	2.397e-183	591.0	COG5016@1|root,arCOG02095@2157|Archaea,2XV3W@28890|Euryarchaeota,23PD1@183925|Methanobacteria	183925|Methanobacteria	C	TIGRFAM oxaloacetate decarboxylase alpha subunit	pycB	-	6.4.1.1	ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
SRD2_k127_6165407_5	1449048.JQKU01000008_gene1140	2.057e-96	328.0	COG2267@1|root,COG2267@2|Bacteria,2I3AI@201174|Actinobacteria,235K9@1762|Mycobacteriaceae	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	3.8.1.5	ko:K01563	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05284,R05367,R05368,R05369,R05370,R07669,R07670	RC01317,RC01340,RC01341,RC02013	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
SRD2_k127_6165407_6	479434.Sthe_1820	1.447e-44	170.0	COG0041@1|root,COG0041@2|Bacteria,2G6JS@200795|Chloroflexi,27YJ0@189775|Thermomicrobia	189775|Thermomicrobia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
SRD2_k127_6165407_4	479434.Sthe_1365	3.853e-123	409.0	COG0151@1|root,COG0151@2|Bacteria,2G5ZE@200795|Chloroflexi,27XZU@189775|Thermomicrobia	189775|Thermomicrobia	F	Phosphoribosylglycinamide synthetase, C domain	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
SRD2_k127_6165407_0	555079.Toce_0353	2.203e-207	658.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1TPG8@1239|Firmicutes,2487F@186801|Clostridia,42EXT@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans
SRD2_k127_6165407_3	552811.Dehly_0137	1.792e-141	459.0	COG0516@1|root,COG0516@2|Bacteria,2G5ZX@200795|Chloroflexi,34CRY@301297|Dehalococcoidia	301297|Dehalococcoidia	C	IMP dehydrogenase / GMP reductase domain	-	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	IMPDH
SRD2_k127_6165407_11	316274.Haur_4150	5.229e-10	69.0	COG3393@1|root,COG3393@2|Bacteria	2|Bacteria	S	Acetyltransferase (GNAT) family	MA20_27790	-	-	ko:K06976	-	-	-	-	ko00000	-	-	-	Acetyltransf_1,FR47
SRD2_k127_6165407_12	292459.STH714	1.446e-09	66.0	COG3764@1|root,COG3764@2|Bacteria	2|Bacteria	M	Sortase family	-	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
SRD2_k127_6165407_2	1128421.JAGA01000002_gene119	7.31e-157	513.0	COG0334@1|root,COG0334@2|Bacteria,2NNRJ@2323|unclassified Bacteria	2|Bacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
SRD2_k127_6165407_8	767029.HMPREF9154_2738	2.609e-20	100.0	COG3879@1|root,COG3879@2|Bacteria,2GJ9Y@201174|Actinobacteria,4DRBX@85009|Propionibacteriales	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF881)	-	-	-	-	-	-	-	-	-	-	-	-	DUF881
SRD2_k127_6165407_10	888052.HMPREF9006_0087	6.043e-17	89.0	COG3879@1|root,COG3879@2|Bacteria,2GJ3C@201174|Actinobacteria,4D4RS@85005|Actinomycetales	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF881)	-	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF881
SRD2_k127_6198522_6	644966.Tmar_1413	3.636e-107	357.0	COG2896@1|root,COG2896@2|Bacteria,1TP89@1239|Firmicutes,247PP@186801|Clostridia,3WCYS@538999|Clostridiales incertae sedis	186801|Clostridia	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
SRD2_k127_6198522_7	386456.JQKN01000011_gene815	1.456e-102	348.0	COG2239@1|root,arCOG00634@2157|Archaea,2XWIB@28890|Euryarchaeota,23PEC@183925|Methanobacteria	183925|Methanobacteria	P	MgtE intracellular N domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,MgtE_N,PRC
SRD2_k127_6198522_3	351627.Csac_1223	3.587e-124	410.0	COG1914@1|root,COG1914@2|Bacteria,1TPT1@1239|Firmicutes,24ACU@186801|Clostridia,42F5H@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
SRD2_k127_6198522_10	903818.KI912268_gene2600	9.032e-38	155.0	COG0524@1|root,COG0524@2|Bacteria,3Y3GE@57723|Acidobacteria	57723|Acidobacteria	G	PfkB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
SRD2_k127_6198522_5	243164.DET1206	4.423e-108	368.0	COG0460@1|root,COG0460@2|Bacteria,2G6PU@200795|Chloroflexi,34D8M@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Homoserine dehydrogenase	metM	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
SRD2_k127_6198522_2	596315.HMPREF0634_0782	1.432e-128	424.0	COG0498@1|root,COG0498@2|Bacteria,1TP25@1239|Firmicutes,25B08@186801|Clostridia,25QDJ@186804|Peptostreptococcaceae	186801|Clostridia	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SRD2_k127_6198522_8	696281.Desru_2927	2.027e-60	234.0	COG0083@1|root,COG0083@2|Bacteria,1TRWS@1239|Firmicutes,248NA@186801|Clostridia,26127@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	-	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS03525	GHMP_kinases_C,GHMP_kinases_N
SRD2_k127_6198522_1	311424.DhcVS_1515	3.572e-135	443.0	COG0527@1|root,COG0527@2|Bacteria,2G5U9@200795|Chloroflexi,34CW8@301297|Dehalococcoidia	301297|Dehalococcoidia	E	ACT domain	metL	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT
SRD2_k127_6198522_11	1392502.JNIO01000008_gene2989	2.081e-07	62.0	COG4481@1|root,COG4481@2|Bacteria	2|Bacteria	S	Bacterial protein of unknown function (DUF951)	yyzM	-	-	-	-	-	-	-	-	-	-	-	DUF951
SRD2_k127_6198522_4	351627.Csac_1719	9.524e-124	407.0	COG0012@1|root,COG0012@2|Bacteria,1TPRK@1239|Firmicutes,2482Z@186801|Clostridia,42FGS@68295|Thermoanaerobacterales	186801|Clostridia	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
SRD2_k127_6198522_9	1128421.JAGA01000002_gene32	3.56e-48	182.0	COG0095@1|root,COG0095@2|Bacteria,2NPP1@2323|unclassified Bacteria	2|Bacteria	H	Biotin/lipoate A/B protein ligase family	lipM	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
SRD2_k127_6198522_0	292459.STH230	0.0	1480.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1TQ0B@1239|Firmicutes,248IB@186801|Clostridia	186801|Clostridia	E	'glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
SRD2_k127_6214205_5	380358.XALC_2481	4.585e-10	68.0	2ANYX@1|root,31DZX@2|Bacteria,1QB9Z@1224|Proteobacteria,1T6UK@1236|Gammaproteobacteria,1X7GH@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
SRD2_k127_6214205_2	525368.HMPREF0591_4205	3.342e-47	181.0	COG0332@1|root,COG0332@2|Bacteria,2IK61@201174|Actinobacteria,233IG@1762|Mycobacteriaceae	201174|Actinobacteria	I	3-Oxoacyl- acyl-carrier-protein (ACP) synthase III	-	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
SRD2_k127_6214205_1	931627.MycrhDRAFT_3319	3.475e-109	366.0	COG0332@1|root,COG0332@2|Bacteria,2I9C8@201174|Actinobacteria,23EW9@1762|Mycobacteriaceae	201174|Actinobacteria	I	3-Oxoacyl- acyl-carrier-protein (ACP) synthase III	-	-	2.3.1.180	ko:K00648,ko:K22317	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
SRD2_k127_6214205_3	1120934.KB894452_gene2652	2.175e-40	160.0	COG3448@1|root,COG3448@2|Bacteria,2I3G0@201174|Actinobacteria,4E3DH@85010|Pseudonocardiales	201174|Actinobacteria	T	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON,CBS
SRD2_k127_6214205_4	1128421.JAGA01000002_gene1258	1.079e-13	81.0	COG0517@1|root,COG1993@1|root,COG0517@2|Bacteria,COG1993@2|Bacteria,2NPXF@2323|unclassified Bacteria	2|Bacteria	T	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	CBS,DUF190
SRD2_k127_6214205_6	351607.Acel_0515	3.151e-06	58.0	2BM3X@1|root,33KY1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_6214205_0	1242864.D187_002420	3.401e-130	431.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42MQJ@68525|delta/epsilon subdivisions,2WJIX@28221|Deltaproteobacteria,2YX9E@29|Myxococcales	28221|Deltaproteobacteria	P	Hemerythrin HHE cation binding domain	-	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,Hemerythrin,Hydrolase
SRD2_k127_6226258_19	75379.Tint_1200	0.000458	48.0	COG1261@1|root,COG1261@2|Bacteria,1N1SA@1224|Proteobacteria,2VR6V@28216|Betaproteobacteria,1KKTA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	N	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly	flgA	-	-	ko:K02386	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	ChapFlgA
SRD2_k127_6226258_16	338963.Pcar_1749	3.288e-08	61.0	COG4961@1|root,COG4961@2|Bacteria,1N76N@1224|Proteobacteria,42VUR@68525|delta/epsilon subdivisions,2WRQU@28221|Deltaproteobacteria,43SSK@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
SRD2_k127_6226258_10	666686.B1NLA3E_21090	6.425e-28	130.0	COG4963@1|root,COG4963@2|Bacteria,1UF2S@1239|Firmicutes,4ITZ3@91061|Bacilli,1ZE58@1386|Bacillus	91061|Bacilli	D	Cellulose biosynthesis protein BcsQ	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31
SRD2_k127_6226258_3	266117.Rxyl_2480	1.15e-84	307.0	COG1071@1|root,COG1071@2|Bacteria,2GK3W@201174|Actinobacteria,4CT3Y@84995|Rubrobacteria	84995|Rubrobacteria	C	Dehydrogenase E1 component	-	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
SRD2_k127_6226258_0	1384049.CD29_11705	2.24e-118	407.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,4HAP6@91061|Bacilli,3IX5Q@400634|Lysinibacillus	91061|Bacilli	C	2-oxoisovalerate dehydrogenase	bfmBAB	-	1.2.4.4	ko:K00167,ko:K21417	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU24040	Transket_pyr,Transketolase_C
SRD2_k127_6226258_1	869210.Marky_1366	2.187e-114	376.0	COG3396@1|root,COG3396@2|Bacteria,1WI17@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	TIGRFAM phenylacetate-CoA oxygenase, PaaG subunit	paaA	-	1.14.13.149	ko:K02609	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
SRD2_k127_6226258_17	869210.Marky_1367	6.308e-06	52.0	COG3460@1|root,COG3460@2|Bacteria	2|Bacteria	Q	phenylacetate catabolic process	paaB	-	-	ko:K02610	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	PaaB
SRD2_k127_6226258_6	644966.Tmar_2134	3.912e-39	156.0	COG3396@1|root,COG3396@2|Bacteria,1TPWQ@1239|Firmicutes	1239|Firmicutes	Q	Phenylacetate-CoA oxygenase	paaC	-	1.14.13.149	ko:K02611	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
SRD2_k127_6226258_8	420662.Mpe_A0990	2.704e-34	140.0	COG2151@1|root,COG3677@1|root,COG2151@2|Bacteria,COG3677@2|Bacteria,1RF3S@1224|Proteobacteria,2VQI0@28216|Betaproteobacteria,1KKVW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	TIGRFAM phenylacetate-CoA oxygenase, PaaJ subunit	paaD	-	-	ko:K02612	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FeS_assembly_P
SRD2_k127_6226258_4	1229780.BN381_310066	1.313e-74	278.0	COG0003@1|root,COG0003@2|Bacteria,2GJYN@201174|Actinobacteria	201174|Actinobacteria	D	anion-transporting ATPase	-	-	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
SRD2_k127_6226258_5	1229780.BN381_310065	4.367e-49	187.0	COG0003@1|root,COG0003@2|Bacteria,2GJ0J@201174|Actinobacteria	201174|Actinobacteria	D	Pfam Anion-transporting ATPase	arsA_2	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
SRD2_k127_6226258_13	29306.JOBE01000007_gene3350	4.674e-22	109.0	COG1470@1|root,COG1470@2|Bacteria,2GP8D@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3048) C-terminal domain	yerB	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
SRD2_k127_6226258_14	1246445.ANAY01000002_gene3512	3.596e-20	101.0	COG1309@1|root,COG1309@2|Bacteria,2GP59@201174|Actinobacteria,4EQ00@85012|Streptosporangiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
SRD2_k127_6226258_11	298654.FraEuI1c_1984	7.303e-24	105.0	COG0799@1|root,COG0799@2|Bacteria,2IKZ3@201174|Actinobacteria,4ESRQ@85013|Frankiales	201174|Actinobacteria	S	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
SRD2_k127_6226258_7	429009.Adeg_0190	1.276e-36	157.0	COG1057@1|root,COG1057@2|Bacteria,1V3SK@1239|Firmicutes,24JFM@186801|Clostridia,42EM4@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
SRD2_k127_6226258_2	1121430.JMLG01000002_gene982	3.735e-110	370.0	COG0536@1|root,COG0536@2|Bacteria,1TPX7@1239|Firmicutes,247SP@186801|Clostridia,25ZZB@186807|Peptococcaceae	186801|Clostridia	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
SRD2_k127_6226258_9	439235.Dalk_4115	1.172e-30	126.0	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,42THK@68525|delta/epsilon subdivisions,2WQ2U@28221|Deltaproteobacteria,2MKMM@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
SRD2_k127_6226258_12	1120998.AUFC01000002_gene2831	1.074e-23	109.0	COG0261@1|root,COG0261@2|Bacteria,1V9YH@1239|Firmicutes,24MRS@186801|Clostridia,3WCNF@538999|Clostridiales incertae sedis	186801|Clostridia	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
SRD2_k127_6226258_18	511051.CSE_02410	0.0001086	53.0	COG1361@1|root,COG3210@1|root,COG4719@1|root,COG1361@2|Bacteria,COG3210@2|Bacteria,COG4719@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF11
SRD2_k127_6226258_15	479434.Sthe_2220	4.361e-18	85.0	COG0772@1|root,COG0772@2|Bacteria,2G6GW@200795|Chloroflexi,27XZP@189775|Thermomicrobia	189775|Thermomicrobia	D	Cell cycle protein	-	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
SRD2_k127_6226897_2	525904.Tter_1718	6.073e-141	460.0	COG0438@1|root,COG0438@2|Bacteria,2NQMN@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferases group 1	treT	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1
SRD2_k127_6226897_3	266117.Rxyl_1337	4.317e-106	364.0	COG0661@1|root,COG0661@2|Bacteria,2GJQ6@201174|Actinobacteria,4CR6S@84995|Rubrobacteria	84995|Rubrobacteria	S	ABC1 family	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
SRD2_k127_6226897_5	511051.CSE_14850	4.054e-63	235.0	COG0312@1|root,COG0312@2|Bacteria	2|Bacteria	S	metallopeptidase activity	tldE2	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
SRD2_k127_6226897_0	309799.DICTH_1914	7.766e-151	490.0	COG0312@1|root,COG0312@2|Bacteria	2|Bacteria	S	metallopeptidase activity	tldD2	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
SRD2_k127_6226897_1	309801.trd_0371	3.905e-145	476.0	COG0380@1|root,COG0380@2|Bacteria,2G6F8@200795|Chloroflexi,27XTV@189775|Thermomicrobia	189775|Thermomicrobia	G	Glycosyltransferase family 20	-	-	2.4.1.15,2.4.1.347	ko:K00697	ko00500,ko01100,map00500,map01100	-	R02737	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20
SRD2_k127_6226897_13	479433.Caci_0182	6.914e-17	89.0	2C454@1|root,3440S@2|Bacteria,2GSV4@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_6226897_8	1245475.ANAE01000108_gene3052	1.335e-28	126.0	COG1877@1|root,COG1877@2|Bacteria,2GMKW@201174|Actinobacteria,4EII2@85012|Streptosporangiales	201174|Actinobacteria	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose	otsB	-	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	-	Trehalose_PPase
SRD2_k127_6226897_14	1123389.ATXJ01000004_gene1128	8e-17	89.0	COG0789@1|root,COG0789@2|Bacteria,1WJ4G@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	PFAM MerR family regulatory protein	-	-	-	ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
SRD2_k127_6226897_11	459495.SPLC1_S010640	8.665e-22	100.0	COG0745@1|root,COG0745@2|Bacteria,1G1EZ@1117|Cyanobacteria,1H744@1150|Oscillatoriales	1117|Cyanobacteria	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	rpaA	-	-	ko:K10697	ko02020,map02020	M00467	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SRD2_k127_6226897_12	1120936.KB907213_gene4630	3.167e-18	90.0	COG0789@1|root,COG0789@2|Bacteria,2IQJ4@201174|Actinobacteria,4EJXG@85012|Streptosporangiales	201174|Actinobacteria	K	MerR HTH family regulatory protein	hspR	GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
SRD2_k127_6226897_4	1128421.JAGA01000002_gene1247	8.026e-99	350.0	COG0744@1|root,COG0744@2|Bacteria	2|Bacteria	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mrcB	-	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
SRD2_k127_6226897_9	1121472.AQWN01000005_gene2503	8.126e-28	118.0	COG1959@1|root,COG1959@2|Bacteria,1V3QB@1239|Firmicutes,24JIV@186801|Clostridia,261XS@186807|Peptococcaceae	186801|Clostridia	K	transcriptional regulator	iscR	-	-	-	-	-	-	-	-	-	-	-	Rrf2
SRD2_k127_6226897_10	941449.dsx2_1679	1.063e-23	117.0	COG4745@1|root,COG4745@2|Bacteria	2|Bacteria	O	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
SRD2_k127_6226897_15	1151127.KB906331_gene3246	5.209e-12	78.0	COG5305@1|root,COG5305@2|Bacteria,1R9UF@1224|Proteobacteria,1S0JK@1236|Gammaproteobacteria,1YMK4@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
SRD2_k127_6226897_16	1463903.JOIZ01000013_gene1869	1.454e-06	59.0	COG0517@1|root,COG0517@2|Bacteria,2IHPB@201174|Actinobacteria	201174|Actinobacteria	S	Cbs domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SRD2_k127_6226897_17	1125863.JAFN01000001_gene3384	0.0002151	49.0	COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,42NIF@68525|delta/epsilon subdivisions,2WJST@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	CBS domain containing protein	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
SRD2_k127_6226897_7	929712.KI912613_gene2019	1.927e-29	128.0	COG2864@1|root,COG2864@2|Bacteria	2|Bacteria	C	formate dehydrogenase	fdnI	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
SRD2_k127_6226897_6	1121877.JQKF01000010_gene699	1.921e-49	187.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria	201174|Actinobacteria	M	Oxidoreductase molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
SRD2_k127_6260732_13	28444.JODQ01000013_gene2933	3.092e-34	134.0	COG4430@1|root,COG4430@2|Bacteria,2II0D@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
SRD2_k127_6260732_8	485913.Krac_6166	2.455e-54	196.0	COG0778@1|root,COG0778@2|Bacteria,2G7DQ@200795|Chloroflexi	200795|Chloroflexi	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SRD2_k127_6260732_21	593907.Celgi_2767	0.0004132	44.0	COG4430@1|root,COG4430@2|Bacteria,2II0D@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
SRD2_k127_6260732_17	91464.S7335_5102	1.045e-16	81.0	COG4430@1|root,COG4430@2|Bacteria,1G2ES@1117|Cyanobacteria,1H343@1129|Synechococcus	1117|Cyanobacteria	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
SRD2_k127_6260732_19	29850.GGTG_05475T0	1.248e-05	47.0	COG4430@1|root,2SA7D@2759|Eukaryota,3AE2B@33154|Opisthokonta,3P5CE@4751|Fungi,3QUC5@4890|Ascomycota,219IP@147550|Sordariomycetes,41NKR@639021|Magnaporthales	4751|Fungi	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
SRD2_k127_6260732_5	1205680.CAKO01000038_gene1763	4.415e-91	317.0	COG0654@1|root,COG0654@2|Bacteria,1MUN4@1224|Proteobacteria,2TQT8@28211|Alphaproteobacteria,2JT41@204441|Rhodospirillales	204441|Rhodospirillales	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
SRD2_k127_6260732_1	479434.Sthe_1229	9.792e-138	456.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE
SRD2_k127_6260732_20	1123507.ATVQ01000001_gene1631	9.31e-05	46.0	2BD34@1|root,326QM@2|Bacteria,2HC94@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_6260732_14	1077972.ARGLB_073_01350	5.106e-32	138.0	COG3064@1|root,COG3064@2|Bacteria,2IPMP@201174|Actinobacteria	201174|Actinobacteria	M	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_6260732_0	1137269.AZWL01000001_gene5688	2.558e-214	679.0	COG0277@1|root,COG0277@2|Bacteria,2GIS6@201174|Actinobacteria	201174|Actinobacteria	C	FAD linked	agpS	-	2.5.1.26	ko:K00803	ko00565,ko01100,ko04146,map00565,map01100,map04146	-	R04311	RC00020,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
SRD2_k127_6260732_2	867903.ThesuDRAFT_01054	6.597e-119	387.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia	186801|Clostridia	IQ	reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SRD2_k127_6260732_10	1379698.RBG1_1C00001G0822	3.008e-51	203.0	COG0580@1|root,COG0580@2|Bacteria,2NQ7N@2323|unclassified Bacteria	2|Bacteria	U	Belongs to the MIP aquaporin (TC 1.A.8) family	glpF	-	-	ko:K02440,ko:K06188,ko:K09874	-	-	-	-	ko00000,ko02000	1.A.8,1.A.8.1,1.A.8.12,1.A.8.2	-	-	MIP
SRD2_k127_6260732_15	1261545.MBE-HAL_0965	1.824e-20	101.0	arCOG12117@1|root,arCOG12117@2157|Archaea,2XXVR@28890|Euryarchaeota,23WGQ@183963|Halobacteria	183963|Halobacteria	S	Protein of unknown function (DUF3891)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3891
SRD2_k127_6260732_6	292459.STH1050	5.193e-80	276.0	COG1801@1|root,COG1801@2|Bacteria,1TPX4@1239|Firmicutes,24F1Y@186801|Clostridia	186801|Clostridia	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
SRD2_k127_6260732_18	1120958.AULD01000006_gene165	8.955e-06	55.0	2C9IE@1|root,32UBS@2|Bacteria,2INT4@201174|Actinobacteria,4FNU6@85023|Microbacteriaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4383)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4383
SRD2_k127_6260732_16	745776.DGo_CA0109	1.481e-17	96.0	COG0628@1|root,COG0628@2|Bacteria,1WIXU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	COGs COG0628 permease	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
SRD2_k127_6260732_9	1382356.JQMP01000003_gene2008	6.163e-53	192.0	COG2323@1|root,COG2323@2|Bacteria,2GBW1@200795|Chloroflexi,27YMQ@189775|Thermomicrobia	189775|Thermomicrobia	S	Protein of unknown function (DUF421)	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
SRD2_k127_6260732_4	66377.JOBH01000016_gene5628	2.353e-102	355.0	COG1960@1|root,COG1960@2|Bacteria,2GJHM@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
SRD2_k127_6260732_3	1218076.BAYB01000008_gene1501	8.599e-109	363.0	COG2042@1|root,COG3376@2|Bacteria,1MUYH@1224|Proteobacteria,2VP4K@28216|Betaproteobacteria,1KHKF@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the NiCoT transporter (TC 2.A.52) family	hoxN	-	-	ko:K07241	-	-	-	-	ko00000,ko02000	2.A.52.1	-	-	NicO
SRD2_k127_6260732_11	1266925.JHVX01000006_gene2133	5.443e-51	200.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2VSHQ@28216|Betaproteobacteria,373GQ@32003|Nitrosomonadales	28216|Betaproteobacteria	C	SelR domain	msrB	-	1.8.4.11,1.8.4.12	ko:K07305,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	SelR
SRD2_k127_6260732_12	1214101.BN159_8033	4.053e-38	152.0	COG0406@1|root,COG0406@2|Bacteria	2|Bacteria	G	alpha-ribazole phosphatase activity	mutT	-	3.1.3.73,3.6.1.55,5.4.2.11,5.4.2.12	ko:K01834,ko:K02226,ko:K03574,ko:K15634	ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003,M00122	R01518,R04594,R11173	RC00017,RC00536	ko00000,ko00001,ko00002,ko01000,ko03400,ko04131,ko04147	-	-	-	His_Phos_1,NUDIX
SRD2_k127_6260732_7	931627.MycrhDRAFT_1689	3.083e-75	262.0	COG3173@1|root,COG3173@2|Bacteria,2GNNV@201174|Actinobacteria,235T8@1762|Mycobacteriaceae	201174|Actinobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
SRD2_k127_629541_3	1227487.C474_05755	2.111e-15	76.0	COG0537@1|root,arCOG00419@2157|Archaea,2XWGT@28890|Euryarchaeota,23V8J@183963|Halobacteria	183963|Halobacteria	F	COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases	hit1	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
SRD2_k127_629541_2	1121946.AUAX01000019_gene7790	3.57e-32	144.0	COG0388@1|root,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
SRD2_k127_629541_0	1121422.AUMW01000020_gene1732	1.13e-165	529.0	COG1960@1|root,COG1960@2|Bacteria,1UYXJ@1239|Firmicutes,25BWS@186801|Clostridia,264HJ@186807|Peptococcaceae	186801|Clostridia	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	ko:K11731	ko00281,map00281	-	R08089	RC01893	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SRD2_k127_629541_1	525909.Afer_0085	4.207e-124	408.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4CMTJ@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
SRD2_k127_6331327_0	1120936.KB907211_gene456	4.925e-141	462.0	COG0155@1|root,COG0155@2|Bacteria,2GJRN@201174|Actinobacteria,4EFX9@85012|Streptosporangiales	201174|Actinobacteria	P	Nitrite and sulphite reductase 4Fe-4S domain	sir	GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016002,GO:0016053,GO:0016491,GO:0016667,GO:0016673,GO:0019344,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050311,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.7.7.1,1.8.7.1	ko:K00366,ko:K00392	ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120	M00176,M00531	R00790,R00859,R03600	RC00065,RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
SRD2_k127_6331327_2	518766.Rmar_2356	1.178e-83	285.0	COG0175@1|root,COG0175@2|Bacteria,4NGVI@976|Bacteroidetes,1FJG5@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	EH	Belongs to the PAPS reductase family. CysH subfamily	cysH	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
SRD2_k127_6331327_3	1242864.D187_008320	2.094e-54	200.0	COG0007@1|root,COG0007@2|Bacteria,1MUI0@1224|Proteobacteria,42MCB@68525|delta/epsilon subdivisions,2WIRJ@28221|Deltaproteobacteria,2YUYH@29|Myxococcales	28221|Deltaproteobacteria	H	Belongs to the precorrin methyltransferase family	hemD	-	1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4	ko:K02302,ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03165,R03194,R03947	RC00003,RC00871,RC01012,RC01034,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
SRD2_k127_6331327_1	469383.Cwoe_0100	2.63e-97	329.0	COG2267@1|root,COG2267@2|Bacteria,2I6HT@201174|Actinobacteria	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
SRD2_k127_6331327_5	479432.Sros_4245	1.982e-12	75.0	COG5485@1|root,COG5485@2|Bacteria,2I3RT@201174|Actinobacteria,4ER4H@85012|Streptosporangiales	201174|Actinobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
SRD2_k127_6331327_6	28444.JODQ01000005_gene1495	1.896e-11	75.0	COG3631@1|root,COG3631@2|Bacteria,2IFBE@201174|Actinobacteria,4EKUR@85012|Streptosporangiales	201174|Actinobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL,SnoaL_2
SRD2_k127_6331327_4	1382306.JNIM01000001_gene3921	1.373e-48	180.0	COG2071@1|root,COG2071@2|Bacteria,2G6QN@200795|Chloroflexi	200795|Chloroflexi	S	PFAM glutamine amidotransferase class-I	-	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
SRD2_k127_6333789_0	1382306.JNIM01000001_gene1813	1.539e-136	457.0	COG0488@1|root,COG0488@2|Bacteria,2G5VD@200795|Chloroflexi	200795|Chloroflexi	S	PFAM ABC transporter related	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
SRD2_k127_6333789_3	1048339.KB913029_gene999	8.575e-05	52.0	2B1MU@1|root,31U3C@2|Bacteria,2GWU5@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4267
SRD2_k127_6333789_1	1463926.JOCA01000002_gene5637	3.964e-62	218.0	COG0302@1|root,COG0302@2|Bacteria,2H2JE@201174|Actinobacteria	201174|Actinobacteria	H	GTP cyclohydrolase I	-	-	-	-	-	-	-	-	-	-	-	-	GTP_cyclohydroI
SRD2_k127_6349457_2	357808.RoseRS_3992	8.357e-34	147.0	COG1807@1|root,COG1807@2|Bacteria,2G8YZ@200795|Chloroflexi	200795|Chloroflexi	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_6349457_0	326427.Cagg_2410	2.283e-50	187.0	COG0596@1|root,COG0596@2|Bacteria,2G6VQ@200795|Chloroflexi,377CS@32061|Chloroflexia	32061|Chloroflexia	S	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
SRD2_k127_6349457_3	997346.HMPREF9374_0091	4.15e-25	121.0	COG3850@1|root,COG3850@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.7.13.3	ko:K03406,ko:K07675	ko02020,ko02030,map02020,map02030	M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	GAF_2,HAMP,HATPase_c,HisKA_3,LapD_MoxY_N,MFS_1
SRD2_k127_6349457_1	266117.Rxyl_0160	1.945e-46	176.0	COG2197@1|root,COG2197@2|Bacteria,2GJRY@201174|Actinobacteria,4CQ2W@84995|Rubrobacteria	84995|Rubrobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
SRD2_k127_6355446_2	479433.Caci_4379	1.253e-37	144.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
SRD2_k127_6355446_0	1121430.JMLG01000001_gene2381	8.296e-76	281.0	COG3437@1|root,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia,260BC@186807|Peptococcaceae	186801|Clostridia	T	TIGRFAM Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD,HD_5
SRD2_k127_6355446_1	1206729.BAFZ01000058_gene3375	1.403e-63	227.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,4FUDW@85025|Nocardiaceae	1206729.BAFZ01000058_gene3375|-	J	Belongs to the amidase family	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_6439706_0	886293.Sinac_5855	1.861e-164	535.0	COG3280@1|root,COG3280@2|Bacteria,2IYFT@203682|Planctomycetes	203682|Planctomycetes	G	Alpha amylase, catalytic domain	-	-	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	Alpha-amylase
SRD2_k127_6439706_1	1266908.AQPB01000033_gene1662	1.329e-102	346.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,1RP2N@1236|Gammaproteobacteria,1WWIM@135613|Chromatiales	135613|Chromatiales	G	TIGRFAM malto-oligosyltrehalose trehalohydrolase	-	-	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
SRD2_k127_6451899_22	935567.JAES01000008_gene1925	0.0002882	52.0	COG1476@1|root,COG1476@2|Bacteria,1N6SS@1224|Proteobacteria,1SCB0@1236|Gammaproteobacteria,1XD0A@135614|Xanthomonadales	135614|Xanthomonadales	K	Helix-turn-helix domain	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
SRD2_k127_6451899_17	1123252.ATZF01000011_gene3154	3.183e-22	105.0	COG1539@1|root,COG1539@2|Bacteria,1VA0I@1239|Firmicutes,4HKKK@91061|Bacilli,27C6J@186824|Thermoactinomycetaceae	91061|Bacilli	H	Dihydroneopterin aldolase	folB	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
SRD2_k127_6451899_4	926569.ANT_23230	2.028e-78	280.0	COG1641@1|root,COG1641@2|Bacteria,2G5MP@200795|Chloroflexi	200795|Chloroflexi	S	Belongs to the LarC family	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
SRD2_k127_6451899_2	1437824.BN940_09816	3.692e-98	329.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2VI8C@28216|Betaproteobacteria,3T390@506|Alcaligenaceae	28216|Betaproteobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
SRD2_k127_6451899_5	555079.Toce_0685	1.171e-75	277.0	COG0285@1|root,COG0285@2|Bacteria,1TPX5@1239|Firmicutes,247PC@186801|Clostridia,42EM6@68295|Thermoanaerobacterales	186801|Clostridia	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
SRD2_k127_6451899_21	1207055.C100_04310	3.702e-10	72.0	COG0613@1|root,COG0613@2|Bacteria	2|Bacteria	Q	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_6451899_1	1122247.C731_4072	1.711e-114	380.0	COG1575@1|root,COG1575@2|Bacteria,2IPQ8@201174|Actinobacteria,23E29@1762|Mycobacteriaceae	201174|Actinobacteria	H	Belongs to the MenA family. Type 1 subfamily	-	-	-	-	-	-	-	-	-	-	-	-	UbiA
SRD2_k127_6451899_10	1048834.TC41_1588	2.18e-43	175.0	COG0142@1|root,COG0142@2|Bacteria,1TR0U@1239|Firmicutes,4H9RH@91061|Bacilli,27855@186823|Alicyclobacillaceae	91061|Bacilli	H	Belongs to the FPP GGPP synthase family	hepT	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.5.1.30,2.5.1.83	ko:K00805,ko:K21275	ko00900,ko01110,map00900,map01110	-	R09245,R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
SRD2_k127_6451899_15	479434.Sthe_0335	3.536e-29	135.0	COG2340@1|root,COG2340@2|Bacteria,2G8G6@200795|Chloroflexi,27XTT@189775|Thermomicrobia	189775|Thermomicrobia	S	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP
SRD2_k127_6451899_11	358823.DF19_00585	2.908e-43	178.0	COG0642@1|root,COG2205@2|Bacteria	358823.DF19_00585|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_6451899_12	861299.J421_3798	4.693e-42	167.0	COG0315@1|root,COG0315@2|Bacteria,1ZU6G@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
SRD2_k127_6451899_16	1122138.AQUZ01000035_gene6519	2.754e-23	103.0	COG0745@1|root,COG0745@2|Bacteria,2GJE6@201174|Actinobacteria,4DP53@85009|Propionibacteriales	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07670	ko02020,map02020	M00461	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SRD2_k127_6451899_3	290397.Adeh_0141	2.845e-87	309.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,42NGG@68525|delta/epsilon subdivisions,2WIVT@28221|Deltaproteobacteria,2YU4K@29|Myxococcales	28221|Deltaproteobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
SRD2_k127_6451899_23	445335.CBN_0795	0.0009022	53.0	COG1396@1|root,COG1396@2|Bacteria,1VKJA@1239|Firmicutes,24G72@186801|Clostridia,36I1Y@31979|Clostridiaceae	186801|Clostridia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
SRD2_k127_6451899_20	758.BBIX01000006_gene587	1.281e-11	79.0	COG1044@1|root,COG2911@1|root,COG5295@1|root,COG1044@2|Bacteria,COG2911@2|Bacteria,COG5295@2|Bacteria	2|Bacteria	UW	Hep Hag repeat protein	ydcK	-	-	ko:K07004,ko:K15125,ko:K20276	ko02024,ko05133,map02024,map05133	-	-	-	ko00000,ko00001,ko00536	-	-	-	ESPR,Fil_haemagg_2,Haemagg_act,HemolysinCabind
SRD2_k127_6451899_13	502025.Hoch_0319	8.111e-39	164.0	COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,42PVX@68525|delta/epsilon subdivisions,2WIJ8@28221|Deltaproteobacteria,2Z2WU@29|Myxococcales	28221|Deltaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF
SRD2_k127_6451899_18	1713.JOFV01000008_gene3203	5.58e-21	103.0	COG2353@1|root,COG2353@2|Bacteria,2IM4N@201174|Actinobacteria,4F2JQ@85016|Cellulomonadaceae	201174|Actinobacteria	S	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
SRD2_k127_6451899_19	365528.KB891241_gene6175	3.716e-12	79.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	3.1.3.10	ko:K07025,ko:K20866	ko00010,ko01120,map00010,map01120	-	R00947	RC00078	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase,Hydrolase_like
SRD2_k127_6451899_9	368407.Memar_0638	4.202e-55	212.0	COG0648@1|root,arCOG01894@2157|Archaea,2XV5I@28890|Euryarchaeota	28890|Euryarchaeota	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
SRD2_k127_6451899_8	266117.Rxyl_3054	5.575e-57	208.0	COG1691@1|root,COG1691@2|Bacteria,2IAKU@201174|Actinobacteria	201174|Actinobacteria	C	(AIR) carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
SRD2_k127_6451899_14	1380390.JIAT01000014_gene6036	1.333e-32	132.0	COG1595@1|root,COG1595@2|Bacteria,2II47@201174|Actinobacteria,4CSB0@84995|Rubrobacteria	84995|Rubrobacteria	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
SRD2_k127_6451899_7	1380390.JIAT01000014_gene6037	9.216e-58	207.0	COG0350@1|root,COG0350@2|Bacteria,2GKA9@201174|Actinobacteria,4CQVT@84995|Rubrobacteria	84995|Rubrobacteria	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DNA_binding_1
SRD2_k127_6451899_0	273068.TTE2465	6.408e-123	408.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,42FGX@68295|Thermoanaerobacterales	186801|Clostridia	H	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
SRD2_k127_6451899_6	1089544.KB912942_gene2377	5.906e-58	221.0	28JU0@1|root,2Z9J3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_6511604_2	1337093.MBE-LCI_2197	1.139e-05	58.0	COG1295@1|root,COG1295@2|Bacteria,1MXQA@1224|Proteobacteria,2TSFP@28211|Alphaproteobacteria,2P96F@245186|Loktanella	28211|Alphaproteobacteria	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
SRD2_k127_6511604_0	561175.KB894093_gene3762	8.787e-59	212.0	COG1309@1|root,COG1309@2|Bacteria,2GJES@201174|Actinobacteria,4EIGA@85012|Streptosporangiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
SRD2_k127_6511604_1	1116232.AHBF01000018_gene3813	5.729e-36	146.0	2DN6W@1|root,32UIF@2|Bacteria,2IFGD@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_651301_0	118173.KB235910_gene4553	2.029e-148	481.0	COG0498@1|root,COG0498@2|Bacteria,1G0SV@1117|Cyanobacteria,1H8HF@1150|Oscillatoriales	1117|Cyanobacteria	E	Threonine synthase	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SRD2_k127_651301_15	547144.HydHO_0121	1.201e-27	114.0	COG1977@1|root,COG1977@2|Bacteria,2G563@200783|Aquificae	200783|Aquificae	H	TIGRFAM MoaD family protein	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
SRD2_k127_651301_22	330214.NIDE1817	1.138e-12	70.0	COG1135@1|root,COG1135@2|Bacteria,3J0VT@40117|Nitrospirae	40117|Nitrospirae	P	NIL	-	-	-	-	-	-	-	-	-	-	-	-	NIL
SRD2_k127_651301_5	1232410.KI421413_gene842	6.014e-94	320.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,42MZR@68525|delta/epsilon subdivisions,2WK6B@28221|Deltaproteobacteria,43SZM@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
SRD2_k127_651301_13	59931.WH7805_07971	1.141e-29	121.0	COG0838@1|root,COG0838@2|Bacteria,1G5RH@1117|Cyanobacteria,1H0GX@1129|Synechococcus	1117|Cyanobacteria	C	electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon- concentration	ndhC	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494	1.6.5.3	ko:K05574	ko00190,ko01100,map00190,map01100	M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_q4
SRD2_k127_651301_10	278957.ABEA03000176_gene2797	2.077e-55	202.0	COG0377@1|root,COG0377@2|Bacteria,46YVB@74201|Verrucomicrobia,3K85T@414999|Opitutae	414999|Opitutae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
SRD2_k127_651301_19	1128421.JAGA01000002_gene1901	5.843e-21	107.0	COG0852@1|root,COG0852@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204	1.6.5.3	ko:K00332,ko:K00333,ko:K13378,ko:K13380	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iECDH10B_1368.ECDH10B_2448,iECDH1ME8569_1439.ECDH1ME8569_2223,iETEC_1333.ETEC_2421,iEcDH1_1363.EcDH1_1371,iPC815.YPO2553,iUMNK88_1353.UMNK88_2836	Complex1_30kDa,Complex1_49kDa
SRD2_k127_651301_3	552811.Dehly_0834	1.392e-115	388.0	COG0649@1|root,COG0649@2|Bacteria,2G5JF@200795|Chloroflexi,34D5Q@301297|Dehalococcoidia	301297|Dehalococcoidia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
SRD2_k127_651301_7	1121472.AQWN01000005_gene2476	3.141e-87	300.0	COG1005@1|root,COG1005@2|Bacteria,1TQNU@1239|Firmicutes,25E6Z@186801|Clostridia,260SW@186807|Peptococcaceae	186801|Clostridia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
SRD2_k127_651301_20	1136417.AZWE01000036_gene1052	2.038e-20	106.0	COG1143@1|root,COG1143@2|Bacteria,2GPSS@201174|Actinobacteria,4DB0N@85008|Micromonosporales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI2	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
SRD2_k127_651301_17	246194.CHY_1419	2.577e-23	106.0	COG0839@1|root,COG0839@2|Bacteria,1VAQI@1239|Firmicutes,24NAC@186801|Clostridia,42GTX@68295|Thermoanaerobacterales	186801|Clostridia	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	ndhG	-	1.6.5.3	ko:K00339,ko:K05578	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
SRD2_k127_651301_18	868595.Desca_1117	2.033e-22	100.0	COG0713@1|root,COG0713@2|Bacteria,1V9Z8@1239|Firmicutes,24NKG@186801|Clostridia,262H1@186807|Peptococcaceae	186801|Clostridia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340,ko:K05576	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
SRD2_k127_651301_1	562970.Btus_3223	7.734e-137	458.0	COG1009@1|root,COG1009@2|Bacteria,1TQW4@1239|Firmicutes,4H9YR@91061|Bacilli,27873@186823|Alicyclobacillaceae	91061|Bacilli	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
SRD2_k127_651301_2	118005.AWNK01000008_gene424	8.223e-135	452.0	COG1008@1|root,COG1008@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoM2	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
SRD2_k127_651301_8	671143.DAMO_2704	3.933e-87	306.0	COG1007@1|root,COG1007@2|Bacteria,2NNMY@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
SRD2_k127_651301_4	1128421.JAGA01000002_gene1247	8.346e-112	389.0	COG0744@1|root,COG0744@2|Bacteria	2|Bacteria	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mrcB	-	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
SRD2_k127_651301_23	383372.Rcas_0344	2.888e-10	72.0	COG0558@1|root,COG0558@2|Bacteria,2GASR@200795|Chloroflexi,3778P@32061|Chloroflexia	32061|Chloroflexia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
SRD2_k127_651301_12	555088.DealDRAFT_2145	1.54e-34	148.0	COG0344@1|root,COG0344@2|Bacteria,1VA3J@1239|Firmicutes,24JA2@186801|Clostridia,42K31@68298|Syntrophomonadaceae	186801|Clostridia	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
SRD2_k127_651301_11	395964.KE386496_gene88	8.354e-47	192.0	COG0642@1|root,COG2972@1|root,COG2205@2|Bacteria,COG2972@2|Bacteria,1NRP8@1224|Proteobacteria,2TQWE@28211|Alphaproteobacteria,3NACX@45404|Beijerinckiaceae	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	MA20_23075	-	-	ko:K20971	ko02025,map02025	-	-	-	ko00000,ko00001,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Response_reg
SRD2_k127_651301_6	868595.Desca_0028	2.877e-87	312.0	COG2812@1|root,COG2812@2|Bacteria,1TPS9@1239|Firmicutes,247J7@186801|Clostridia,2602Z@186807|Peptococcaceae	186801|Clostridia	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
SRD2_k127_651301_14	767817.Desgi_0065	1.051e-27	115.0	COG0718@1|root,COG0718@2|Bacteria,1VA1S@1239|Firmicutes,24MXH@186801|Clostridia,262CP@186807|Peptococcaceae	186801|Clostridia	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
SRD2_k127_651301_9	469371.Tbis_3530	7.215e-69	239.0	COG0353@1|root,COG0353@2|Bacteria,2GJY0@201174|Actinobacteria,4DZAV@85010|Pseudonocardiales	201174|Actinobacteria	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
SRD2_k127_651301_21	1123405.AUMM01000075_gene133	1.215e-14	76.0	2DTS4@1|root,33MFD@2|Bacteria,1VKHK@1239|Firmicutes,4I120@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_651301_16	1408438.JADD01000030_gene1244	2.176e-25	106.0	2DPM9@1|root,332MQ@2|Bacteria,1VGFB@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_651301_25	498761.HM1_3147	6.061e-10	59.0	2EG09@1|root,339SB@2|Bacteria,1VG42@1239|Firmicutes,24W9H@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_6677879_3	1121952.ATXT01000014_gene1329	3.551e-99	330.0	COG2132@1|root,COG4454@1|root,COG2132@2|Bacteria,COG4454@2|Bacteria,2GPUP@201174|Actinobacteria,4FN3E@85023|Microbacteriaceae	201174|Actinobacteria	PQ	Cupredoxin-like domain	aniA	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1
SRD2_k127_6677879_22	1348635.BBJY01000015_gene656	1.194e-22	103.0	2DCA6@1|root,2ZDE1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_6677879_25	1120941.AUBL01000003_gene1912	4.003e-06	50.0	COG3209@1|root,COG3209@2|Bacteria,2GMBB@201174|Actinobacteria,4D4WT@85005|Actinomycetales	201174|Actinobacteria	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_6,PT-HINT,RHS_repeat
SRD2_k127_6677879_5	479432.Sros_4705	3.404e-80	273.0	COG2801@1|root,COG2801@2|Bacteria,2GKDY@201174|Actinobacteria,4EJH2@85012|Streptosporangiales	201174|Actinobacteria	L	HTH-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve
SRD2_k127_6677879_13	485913.Krac_6502	1.081e-46	182.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Big_3_3,LTD,PKD,Pro-kuma_activ,fn3
SRD2_k127_6677879_24	1944.JOAZ01000006_gene649	1.368e-10	63.0	297DF@1|root,2ZUKY@2|Bacteria,2GRA4@201174|Actinobacteria,41BGW@629295|Streptomyces griseus group	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_6677879_14	1408254.T458_17985	1.849e-44	175.0	COG0491@1|root,COG0491@2|Bacteria,1V6FA@1239|Firmicutes,4HHRQ@91061|Bacilli,26SFI@186822|Paenibacillaceae	91061|Bacilli	S	metal-binding protein	glxII	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
SRD2_k127_6677879_10	292459.STH3115	4.076e-62	222.0	COG0566@1|root,COG0566@2|Bacteria,1TP9G@1239|Firmicutes,247SC@186801|Clostridia	186801|Clostridia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	yacO	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
SRD2_k127_6677879_12	309801.trd_1723	4.067e-49	182.0	COG0245@1|root,COG0245@2|Bacteria,2G6RA@200795|Chloroflexi,27YBC@189775|Thermomicrobia	189775|Thermomicrobia	H	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
SRD2_k127_6677879_16	1120973.AQXL01000112_gene1049	1.195e-43	171.0	COG1211@1|root,COG1211@2|Bacteria,1V3M7@1239|Firmicutes,4HH2N@91061|Bacilli,278HX@186823|Alicyclobacillaceae	91061|Bacilli	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
SRD2_k127_6677879_6	1499685.CCFJ01000035_gene1256	6.021e-80	279.0	COG4956@1|root,COG4956@2|Bacteria,1TP0P@1239|Firmicutes,4H9NQ@91061|Bacilli,1ZB5A@1386|Bacillus	91061|Bacilli	S	COG4956 Integral membrane protein (PIN domain superfamily)	yacL	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	TRAM
SRD2_k127_6677879_0	635013.TherJR_0243	4.631e-320	1002.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,26059@186807|Peptococcaceae	186801|Clostridia	O	Belongs to the ClpA ClpB family	clpC	-	-	ko:K03695,ko:K03696	ko01100,ko04213,map01100,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
SRD2_k127_6677879_4	1121428.DESHY_60191___1	2.047e-89	312.0	COG0539@1|root,COG0761@1|root,COG0539@2|Bacteria,COG0761@2|Bacteria,1TQ9N@1239|Firmicutes,247UK@186801|Clostridia,26081@186807|Peptococcaceae	186801|Clostridia	IJM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K02945,ko:K03527	ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010	M00096,M00178	R05884,R08210	RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011	-	-	-	LYTB,S1
SRD2_k127_6677879_15	1382306.JNIM01000001_gene1162	2.261e-44	187.0	COG0642@1|root,COG2205@2|Bacteria,2G7J9@200795|Chloroflexi	200795|Chloroflexi	T	histidine kinase A domain protein	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,GAF_3,HAMP,HATPase_c,HisKA,dCache_1
SRD2_k127_6677879_19	644968.DFW101_0277	3.852e-35	157.0	COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1MVJY@1224|Proteobacteria,42N7E@68525|delta/epsilon subdivisions,2WK3K@28221|Deltaproteobacteria,2M7U9@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	TIGRFAM Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,EAL,GGDEF
SRD2_k127_6677879_9	1121937.AUHJ01000014_gene2668	3.123e-75	265.0	COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,1RMBU@1236|Gammaproteobacteria,465GA@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Belongs to the NadC ModD family	nadC	GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034213,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	iECP_1309.ECP_0109	QRPTase_C,QRPTase_N
SRD2_k127_6677879_2	1121468.AUBR01000008_gene2064	2.501e-134	445.0	COG0029@1|root,COG0029@2|Bacteria,1UHSP@1239|Firmicutes,25E6F@186801|Clostridia,42ESA@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.3.5.1,1.3.5.4,1.4.3.16	ko:K00239,ko:K00278	ko00020,ko00190,ko00250,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00250,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00115,M00149,M00173,M00374,M00376	R00357,R00481,R02164	RC00006,RC00045,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
SRD2_k127_6677879_18	868864.Dester_1204	1.539e-37	149.0	COG0853@1|root,COG0853@2|Bacteria,2G46P@200783|Aquificae	200783|Aquificae	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
SRD2_k127_6677879_8	1470591.BW41_01260	1.287e-75	271.0	COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,2TS2D@28211|Alphaproteobacteria,2K0S2@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
SRD2_k127_6677879_7	570268.ANBB01000002_gene219	2.759e-76	274.0	COG0413@1|root,COG0413@2|Bacteria,2GJP6@201174|Actinobacteria,4EGTN@85012|Streptosporangiales	201174|Actinobacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	GO:0000287,GO:0003674,GO:0003824,GO:0003864,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0016742,GO:0019752,GO:0032787,GO:0034641,GO:0040007,GO:0042364,GO:0042398,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072330,GO:1901564,GO:1901566,GO:1901576	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
SRD2_k127_6677879_20	656024.FsymDg_3989	5.249e-35	145.0	COG5495@1|root,COG5495@2|Bacteria,2I2F6@201174|Actinobacteria,4ERJ1@85013|Frankiales	201174|Actinobacteria	S	Domain of unknown function (DUF2520)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2520,Rossmann-like
SRD2_k127_6677879_11	1120950.KB892757_gene6616	2.568e-60	228.0	COG0637@1|root,COG0637@2|Bacteria,2IQD3@201174|Actinobacteria,4DRPS@85009|Propionibacteriales	201174|Actinobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
SRD2_k127_6677879_1	1382306.JNIM01000001_gene1179	3.228e-219	698.0	COG0465@1|root,COG0465@2|Bacteria,2G5J3@200795|Chloroflexi	200795|Chloroflexi	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,Peptidase_M41
SRD2_k127_6677879_17	429009.Adeg_2060	9.02e-43	170.0	COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,248TY@186801|Clostridia,42F58@68295|Thermoanaerobacterales	186801|Clostridia	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
SRD2_k127_6677879_23	1288963.ADIS_2835	3.854e-13	83.0	COG3356@1|root,COG3356@2|Bacteria,4NH6U@976|Bacteroidetes,47NFZ@768503|Cytophagia	976|Bacteroidetes	S	PFAM Neutral alkaline nonlysosomal ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
SRD2_k127_6677879_21	1185876.BN8_05038	3.407e-26	111.0	2AYX9@1|root,31R2Z@2|Bacteria,4NNS4@976|Bacteroidetes,47RDY@768503|Cytophagia	976|Bacteroidetes	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
SRD2_k127_6771146_1	1003195.SCAT_3944	1.146e-92	310.0	COG3039@1|root,COG3039@2|Bacteria,2HW75@201174|Actinobacteria	201174|Actinobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
SRD2_k127_6771146_0	1003195.SCAT_3944	9.538e-101	344.0	COG3039@1|root,COG3039@2|Bacteria,2HW75@201174|Actinobacteria	201174|Actinobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
SRD2_k127_6771146_2	749414.SBI_01337	6.602e-63	223.0	COG3039@1|root,COG3039@2|Bacteria,2HW75@201174|Actinobacteria	2|Bacteria	L	PFAM transposase, IS4 family protein	-	-	-	ko:K07481,ko:K07487	-	-	-	-	ko00000	-	-	-	DUF397,DUF772
SRD2_k127_6787630_9	68170.KL590487_gene8819	5.182e-69	243.0	COG0665@1|root,COG0665@2|Bacteria,2GNAE@201174|Actinobacteria,4DYMP@85010|Pseudonocardiales	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
SRD2_k127_6787630_8	886293.Sinac_5338	4.826e-70	253.0	COG1834@1|root,COG1834@2|Bacteria,2IXSX@203682|Planctomycetes	203682|Planctomycetes	E	Amidinotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf
SRD2_k127_6787630_12	1380390.JIAT01000009_gene358	7.558e-55	206.0	COG0208@1|root,COG0208@2|Bacteria,2GK48@201174|Actinobacteria,4CRR0@84995|Rubrobacteria	84995|Rubrobacteria	F	Ribonucleotide reductase, small chain	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_red_sm
SRD2_k127_6787630_22	765420.OSCT_0576	4.984e-22	108.0	COG2021@1|root,COG2021@2|Bacteria,2GBJI@200795|Chloroflexi,377AN@32061|Chloroflexia	32061|Chloroflexia	E	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
SRD2_k127_6787630_1	1048834.TC41_1948	4.601e-142	461.0	COG1960@1|root,COG1960@2|Bacteria,1TPVK@1239|Firmicutes,4HA7B@91061|Bacilli,278UF@186823|Alicyclobacillaceae	91061|Bacilli	C	Acyl-CoA dehydrogenase, N-terminal domain	B4168_2380	-	1.3.99.32	ko:K16173	ko00362,ko01120,map00362,map01120	-	R05579	RC00052	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SRD2_k127_6787630_20	926569.ANT_02430	3.54e-26	117.0	2A1JS@1|root,30PTP@2|Bacteria,2G9H1@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_6787630_6	1223545.GS4_27_00180	9.928e-78	267.0	COG1192@1|root,COG1192@2|Bacteria,2GJX3@201174|Actinobacteria,4GADP@85026|Gordoniaceae	201174|Actinobacteria	D	VirC1 protein	soj	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009295,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0071944	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
SRD2_k127_6787630_4	509191.AEDB02000063_gene452	3.637e-124	414.0	COG4962@1|root,COG4962@2|Bacteria,1TQ0Z@1239|Firmicutes,249VS@186801|Clostridia,3WN0W@541000|Ruminococcaceae	186801|Clostridia	U	Type II/IV secretion system protein	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
SRD2_k127_6787630_24	439375.Oant_0007	5.409e-15	81.0	COG0454@1|root,COG0456@2|Bacteria,1N1SU@1224|Proteobacteria,2UA9R@28211|Alphaproteobacteria,1J41W@118882|Brucellaceae	28211|Alphaproteobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
SRD2_k127_6787630_13	1123023.JIAI01000009_gene944	1.246e-50	194.0	2CBRB@1|root,33SV2@2|Bacteria,2IJ64@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_6787630_21	251221.35213238	7.555e-24	113.0	COG0745@1|root,COG0745@2|Bacteria,1G0YA@1117|Cyanobacteria	1117|Cyanobacteria	K	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	rpaB	-	-	ko:K11329	ko02020,map02020	M00467	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SRD2_k127_6787630_7	272557.APE_2507.1	1.309e-70	251.0	COG0111@1|root,arCOG01754@2157|Archaea,2XRM3@28889|Crenarchaeota	28889|Crenarchaeota	H	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
SRD2_k127_6787630_2	391625.PPSIR1_40340	1.337e-133	464.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2WIXB@28221|Deltaproteobacteria,2YTZ2@29|Myxococcales	28221|Deltaproteobacteria	I	COG1022 Long-chain acyl-CoA synthetases (AMP-forming)	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
SRD2_k127_6787630_3	35760.BCHO_1197	5.595e-127	436.0	COG4581@1|root,COG4581@2|Bacteria,2GJEX@201174|Actinobacteria,4CZEC@85004|Bifidobacteriales	201174|Actinobacteria	L	DEAD DEAH box helicase	helY	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K03727	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DSHCT,Helicase_C,rRNA_proc-arch
SRD2_k127_6787630_19	673860.AciM339_1354	1.072e-27	118.0	arCOG12220@1|root,arCOG12220@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_6787630_15	479434.Sthe_2063	2.735e-44	169.0	COG1573@1|root,COG1573@2|Bacteria,2G8Q5@200795|Chloroflexi	200795|Chloroflexi	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
SRD2_k127_6787630_27	530564.Psta_2340	8.393e-07	62.0	2EEQZ@1|root,338IP@2|Bacteria,2J15B@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_6787630_23	1123405.AUMM01000066_gene1646	1.742e-15	80.0	COG3224@1|root,COG3224@2|Bacteria,1V83H@1239|Firmicutes,4HJC6@91061|Bacilli	91061|Bacilli	S	Ethyl tert-butyl ether degradation	ethD	-	-	-	-	-	-	-	-	-	-	-	EthD
SRD2_k127_6787630_10	1123508.JH636449_gene7420	1.98e-67	256.0	COG2202@1|root,COG4191@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,COG4251@2|Bacteria,2IZ70@203682|Planctomycetes	203682|Planctomycetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9
SRD2_k127_6787630_11	1299327.I546_2763	2.381e-57	216.0	COG2079@1|root,COG2079@2|Bacteria,2HVDJ@201174|Actinobacteria	201174|Actinobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
SRD2_k127_6787630_17	1449126.JQKL01000035_gene2179	1.4e-43	170.0	COG0340@1|root,COG0340@2|Bacteria,1TQCU@1239|Firmicutes,248CK@186801|Clostridia,2685H@186813|unclassified Clostridiales	186801|Clostridia	HK	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
SRD2_k127_6787630_25	485913.Krac_8476	3.095e-10	72.0	COG3794@1|root,COG3794@2|Bacteria,2G7GX@200795|Chloroflexi	200795|Chloroflexi	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
SRD2_k127_6787630_16	383372.Rcas_3554	2.919e-44	170.0	COG3336@1|root,COG3336@2|Bacteria,2G725@200795|Chloroflexi,3779Z@32061|Chloroflexia	32061|Chloroflexia	S	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)	-	-	-	-	-	-	-	-	-	-	-	-	Caa3_CtaG
SRD2_k127_6787630_5	861299.J421_4172	3.206e-87	302.0	COG0109@1|root,COG0109@2|Bacteria,1ZSP3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
SRD2_k127_6787630_18	1110502.TMO_2806	6.94e-35	145.0	COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria	1224|Proteobacteria	O	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
SRD2_k127_6787630_0	1200792.AKYF01000020_gene5231	1.341e-158	519.0	COG0843@1|root,COG0843@2|Bacteria,1TP2U@1239|Firmicutes,4HA4X@91061|Bacilli,26SFP@186822|Paenibacillaceae	91061|Bacilli	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009486,GO:0009987,GO:0015002,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
SRD2_k127_6787630_14	292459.STH2096	1.106e-45	175.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1TRC3@1239|Firmicutes,25348@186801|Clostridia	186801|Clostridia	C	Cytochrome C oxidase subunit II, periplasmic domain	-	-	1.10.3.12,1.9.3.1	ko:K02275,ko:K02826	ko00190,ko01100,map00190,map01100	M00155,M00416	R00081,R09492	RC00016,RC00819	ko00000,ko00001,ko00002,ko01000	3.D.4.1,3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM
SRD2_k127_6787630_26	316067.Geob_0122	3.876e-08	63.0	COG2010@1|root,COG2010@2|Bacteria,1RJJ2@1224|Proteobacteria,42SCM@68525|delta/epsilon subdivisions,2WPS4@28221|Deltaproteobacteria,43U4I@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Cytochrome c	pcmF	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
SRD2_k127_6807242_1	264732.Moth_1868	1.059e-57	205.0	COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,248PB@186801|Clostridia,42FQP@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
SRD2_k127_6807242_0	867903.ThesuDRAFT_02191	5.462e-85	299.0	COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,3WCF4@538999|Clostridiales incertae sedis	186801|Clostridia	L	Helix-hairpin-helix motif	dnaE	-	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
SRD2_k127_6822822_2	479432.Sros_3576	1.625e-113	372.0	2BSDG@1|root,32MFF@2|Bacteria	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_6822822_0	479432.Sros_3575	3.25e-316	989.0	COG2801@1|root,COG2801@2|Bacteria,2HITH@201174|Actinobacteria	201174|Actinobacteria	L	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	Mu-transpos_C,rve
SRD2_k127_6822822_1	67352.JODS01000048_gene3445	6.283e-149	482.0	COG2842@1|root,COG2842@2|Bacteria	2|Bacteria	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,TniB
SRD2_k127_6822822_3	479432.Sros_3573	9.842e-104	360.0	2EKKB@1|root,33EA6@2|Bacteria,2IMNJ@201174|Actinobacteria	201174|Actinobacteria	S	TniQ	-	-	-	-	-	-	-	-	-	-	-	-	TniQ
SRD2_k127_685807_15	1122138.AQUZ01000066_gene4335	6.589e-14	71.0	COG1960@1|root,COG1960@2|Bacteria,2GNTA@201174|Actinobacteria,4DTK6@85009|Propionibacteriales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SRD2_k127_685807_4	1136417.AZWE01000006_gene4278	1.131e-66	247.0	COG2227@1|root,COG2227@2|Bacteria,2GM1S@201174|Actinobacteria,4DMGR@85008|Micromonosporales	201174|Actinobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
SRD2_k127_685807_16	2045.KR76_21840	2.092e-13	78.0	COG5637@1|root,COG5637@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	BON,DUF2892,Polyketide_cyc,Polyketide_cyc2
SRD2_k127_685807_7	118163.Ple7327_4181	9.328e-38	158.0	COG2267@1|root,COG2267@2|Bacteria,1GIY6@1117|Cyanobacteria,3VMFU@52604|Pleurocapsales	1117|Cyanobacteria	I	Alpha/beta hydrolase of unknown function (DUF1057)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
SRD2_k127_685807_3	1394178.AWOO02000032_gene4905	5.873e-73	265.0	COG4427@1|root,COG4427@2|Bacteria,2HVQW@201174|Actinobacteria,4EM18@85012|Streptosporangiales	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2332)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2332
SRD2_k127_685807_0	405948.SACE_0014	1.048e-226	739.0	COG1511@1|root,COG2409@1|root,COG1511@2|Bacteria,COG2409@2|Bacteria,2GIRQ@201174|Actinobacteria,4DZH4@85010|Pseudonocardiales	201174|Actinobacteria	S	RND superfamily	mmpL10	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006629,GO:0006790,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0030312,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044272,GO:0044281,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046505,GO:0046506,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071704,GO:0071944,GO:0075136,GO:1901576	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
SRD2_k127_685807_11	251221.35211042	4.854e-22	105.0	COG1309@1|root,COG1309@2|Bacteria,1GDB4@1117|Cyanobacteria	1117|Cyanobacteria	K	BetI-type transcriptional repressor, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
SRD2_k127_685807_6	1122939.ATUD01000003_gene3488	5.086e-51	192.0	COG5006@1|root,COG5006@2|Bacteria,2GJKB@201174|Actinobacteria,4CPWT@84995|Rubrobacteria	84995|Rubrobacteria	S	EamA-like transporter family	-	-	-	ko:K11939	-	-	-	-	ko00000,ko02000	2.A.7.3.6	-	-	EamA
SRD2_k127_685807_12	887929.HMP0721_1335	2.559e-17	91.0	COG0671@1|root,COG0671@2|Bacteria,1VB7J@1239|Firmicutes,24JDD@186801|Clostridia,25X3Y@186806|Eubacteriaceae	186801|Clostridia	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
SRD2_k127_685807_5	1382306.JNIM01000001_gene152	1.919e-63	233.0	COG0208@1|root,COG0208@2|Bacteria	2|Bacteria	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	-	-	1.17.4.1	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_sm
SRD2_k127_685807_10	1128421.JAGA01000002_gene979	5.485e-28	119.0	2DMUR@1|root,32TTD@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4395)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4395
SRD2_k127_685807_13	1382306.JNIM01000001_gene2571	2.137e-15	81.0	COG0526@1|root,COG0526@2|Bacteria,2G7HX@200795|Chloroflexi	200795|Chloroflexi	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
SRD2_k127_685807_19	222534.KB893705_gene5862	5.085e-06	57.0	COG2887@1|root,COG2887@2|Bacteria,2GJC5@201174|Actinobacteria,4ERNB@85013|Frankiales	201174|Actinobacteria	L	PD-(D/E)XK nuclease superfamily	recB	-	-	ko:K07465	-	-	-	-	ko00000	-	-	-	PDDEXK_1
SRD2_k127_685807_8	1120973.AQXL01000123_gene3083	5.639e-33	139.0	COG1647@1|root,COG1647@2|Bacteria,1TQ7X@1239|Firmicutes,4HBE6@91061|Bacilli,2798Y@186823|Alicyclobacillaceae	91061|Bacilli	S	Serine aminopeptidase, S33	est	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Hydrolase_4
SRD2_k127_685807_2	1121468.AUBR01000014_gene2225	1.777e-97	332.0	COG0547@1|root,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,247WY@186801|Clostridia,42EK5@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
SRD2_k127_685807_1	926550.CLDAP_02840	3.01e-117	406.0	COG2723@1|root,COG2723@2|Bacteria,2G5QE@200795|Chloroflexi	200795|Chloroflexi	G	PFAM glycoside hydrolase, family 1	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
SRD2_k127_685807_18	945713.IALB_0787	1.04e-11	70.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.11.1,4.6.1.1	ko:K01768,ko:K12132	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko01001	-	-	-	DUF3467
SRD2_k127_685807_14	1121468.AUBR01000066_gene909	2.996e-15	82.0	COG2384@1|root,COG2384@2|Bacteria,1V3I4@1239|Firmicutes,24BJI@186801|Clostridia,42G23@68295|Thermoanaerobacterales	186801|Clostridia	S	tRNA (adenine(22)-N(1))-methyltransferase	trmK	-	2.1.1.217	ko:K06967	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_18,TrmK
SRD2_k127_685807_9	1240349.ANGC01000008_gene1100	8.993e-33	141.0	COG0328@1|root,COG0406@1|root,COG0328@2|Bacteria,COG0406@2|Bacteria,2GJ9R@201174|Actinobacteria,4FX7S@85025|Nocardiaceae	201174|Actinobacteria	GL	Reverse transcriptase-like	rnhA	GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576	3.1.26.4,3.1.3.73	ko:K02226,ko:K22316	ko00860,ko01100,ko03030,map00860,map01100,map03030	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	His_Phos_1,RVT_3
SRD2_k127_6909829_0	696369.KI912183_gene629	1.024e-104	370.0	COG1199@1|root,COG2176@1|root,COG1199@2|Bacteria,COG2176@2|Bacteria,1TQHQ@1239|Firmicutes,25C6H@186801|Clostridia,2601V@186807|Peptococcaceae	186801|Clostridia	L	helicase involved in DNA repair and perhaps also replication	dinG	-	2.7.7.7,3.6.4.12	ko:K02342,ko:K03722	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2,RNase_T,RadC,ResIII
SRD2_k127_6909829_1	243231.GSU1866	1.348e-14	74.0	COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,42MK9@68525|delta/epsilon subdivisions,2WJ1C@28221|Deltaproteobacteria,43UHM@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	SMART Nucleotide binding protein, PINc	phoH1	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
SRD2_k127_6974231_11	1304880.JAGB01000004_gene1488	5.673e-114	379.0	COG0059@1|root,COG0059@2|Bacteria,1TPI7@1239|Firmicutes,247RH@186801|Clostridia	186801|Clostridia	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
SRD2_k127_6974231_21	264732.Moth_2257	1.059e-43	168.0	COG0440@1|root,COG0440@2|Bacteria,1V2AJ@1239|Firmicutes,24HZM@186801|Clostridia,42GAW@68295|Thermoanaerobacterales	186801|Clostridia	E	Acetolactate synthase, small subunit	ilvH	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
SRD2_k127_6974231_2	649747.HMPREF0083_02318	4.966e-169	551.0	COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,4H9VR@91061|Bacilli,26QWN@186822|Paenibacillaceae	91061|Bacilli	E	acetolactate synthase	ilvB	-	2.2.1.6	ko:K01652,ko:K16787	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230,map02010	M00019,M00570,M00582	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	iYO844.BSU28310	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
SRD2_k127_6974231_12	292564.Cyagr_0404	2.07e-111	374.0	COG0128@1|root,COG0128@2|Bacteria,1G1F9@1117|Cyanobacteria,22S62@167375|Cyanobium	1117|Cyanobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
SRD2_k127_6974231_19	868595.Desca_2018	8.787e-52	199.0	COG0287@1|root,COG0287@2|Bacteria,1TPXG@1239|Firmicutes,248KX@186801|Clostridia,260K3@186807|Peptococcaceae	186801|Clostridia	E	PFAM Prephenate dehydrogenase	tyrA	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDH
SRD2_k127_6974231_9	635013.TherJR_1599	1.926e-132	433.0	COG2876@1|root,COG2876@2|Bacteria,1TP61@1239|Firmicutes,24812@186801|Clostridia,260FR@186807|Peptococcaceae	186801|Clostridia	E	PFAM DAHP synthetase I	aroF1	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
SRD2_k127_6974231_24	765420.OSCT_0630	7.155e-34	134.0	COG4401@1|root,COG4401@2|Bacteria,2G6VB@200795|Chloroflexi,375RY@32061|Chloroflexia	32061|Chloroflexia	E	PFAM Chorismate mutase of the AroH class	-	-	5.4.99.5	ko:K06208	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_1
SRD2_k127_6974231_13	1128421.JAGA01000002_gene1341	1.988e-81	280.0	COG0159@1|root,COG0159@2|Bacteria,2NP9W@2323|unclassified Bacteria	2|Bacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
SRD2_k127_6974231_4	1379270.AUXF01000006_gene167	7.55e-160	515.0	COG0133@1|root,COG0133@2|Bacteria,1ZSUM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SRD2_k127_6974231_22	671143.DAMO_1415	1.076e-43	173.0	COG0135@1|root,COG0135@2|Bacteria,2NPIX@2323|unclassified Bacteria	2|Bacteria	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
SRD2_k127_6974231_20	478801.Ksed_12880	3.261e-48	189.0	COG0134@1|root,COG0134@2|Bacteria,2GIVV@201174|Actinobacteria,1ZVT1@145357|Dermacoccaceae	201174|Actinobacteria	E	Belongs to the TrpC family	trpC	GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
SRD2_k127_6974231_14	1229780.BN381_70023	2.215e-81	279.0	COG0512@1|root,COG0512@2|Bacteria,2GJUX@201174|Actinobacteria,3UWPF@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	EH	Peptidase C26	trpG	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
SRD2_k127_6974231_6	479434.Sthe_1878	1.285e-138	462.0	COG0147@1|root,COG0147@2|Bacteria,2G5M7@200795|Chloroflexi,27XZ8@189775|Thermomicrobia	189775|Thermomicrobia	H	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
SRD2_k127_6974231_8	309801.trd_A0452	1.692e-133	437.0	COG0436@1|root,COG0436@2|Bacteria,2G5MC@200795|Chloroflexi,27YSW@189775|Thermomicrobia	189775|Thermomicrobia	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
SRD2_k127_6974231_16	255470.cbdbA1335	8.658e-76	282.0	COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,2G6ND@200795|Chloroflexi,34CT3@301297|Dehalococcoidia	301297|Dehalococcoidia	KT	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,HD,HisKA_7TM
SRD2_k127_6974231_1	1382359.JIAL01000001_gene135	4.846e-212	677.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,3Y3NX@57723|Acidobacteria,2JKIA@204432|Acidobacteriia	204432|Acidobacteriia	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
SRD2_k127_6974231_10	240015.ACP_0329	1.935e-122	422.0	COG1013@1|root,COG1013@2|Bacteria,3Y3NE@57723|Acidobacteria,2JIEM@204432|Acidobacteriia	204432|Acidobacteriia	C	Pyruvate ferredoxin oxidoreductase beta subunit C terminal	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
SRD2_k127_6974231_18	383372.Rcas_0320	8.797e-59	226.0	COG0747@1|root,COG0747@2|Bacteria,2G5NC@200795|Chloroflexi,375DK@32061|Chloroflexia	32061|Chloroflexia	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
SRD2_k127_6974231_29	309801.trd_0781	9.385e-08	57.0	COG1314@1|root,COG1314@2|Bacteria,2G7D9@200795|Chloroflexi,27YMZ@189775|Thermomicrobia	189775|Thermomicrobia	U	Preprotein translocase SecG subunit	-	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
SRD2_k127_6974231_23	562970.Btus_1616	8.918e-35	146.0	COG1502@1|root,COG1502@2|Bacteria,1U6K2@1239|Firmicutes,4IGCR@91061|Bacilli,27A4K@186823|Alicyclobacillaceae	91061|Bacilli	I	PLD-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
SRD2_k127_6974231_15	370438.PTH_2721	1.494e-78	271.0	COG0149@1|root,COG0149@2|Bacteria,1TP2F@1239|Firmicutes,248JN@186801|Clostridia,260CH@186807|Peptococcaceae	186801|Clostridia	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
SRD2_k127_6974231_7	562970.Btus_2142	7.466e-138	450.0	COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,4H9R3@91061|Bacilli,277XX@186823|Alicyclobacillaceae	91061|Bacilli	G	Belongs to the phosphoglycerate kinase family	pgk	GO:0001871,GO:0002020,GO:0003674,GO:0003824,GO:0004618,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009893,GO:0009986,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019222,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030162,GO:0030193,GO:0030195,GO:0030246,GO:0030247,GO:0030312,GO:0031323,GO:0031325,GO:0032101,GO:0032102,GO:0032268,GO:0032270,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043532,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0045862,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050818,GO:0050819,GO:0050878,GO:0051171,GO:0051173,GO:0051186,GO:0051188,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051917,GO:0051919,GO:0055086,GO:0060255,GO:0061041,GO:0061045,GO:0065007,GO:0065008,GO:0070613,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0080134,GO:0090407,GO:1900046,GO:1900047,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903034,GO:1903035,GO:1903317,GO:1903319,GO:2001065	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iSB619.SA_RS04145	PGK
SRD2_k127_6974231_5	1157490.EL26_15355	2.474e-147	474.0	COG0057@1|root,COG0057@2|Bacteria,1TNYU@1239|Firmicutes,4H9NS@91061|Bacilli,2796G@186823|Alicyclobacillaceae	91061|Bacilli	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gapA	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
SRD2_k127_6974231_26	1410624.JNKK01000002_gene959	6.163e-28	124.0	COG1481@1|root,COG1481@2|Bacteria,1TP2X@1239|Firmicutes,2484M@186801|Clostridia,27J17@186928|unclassified Lachnospiraceae	186801|Clostridia	K	May be required for sporulation	whiA	-	-	ko:K09762	-	-	-	-	ko00000	-	-	-	HTH_WhiA,LAGLIDADG_WhiA,WhiA_N
SRD2_k127_6974231_25	1121933.AUHH01000009_gene812	2.748e-32	138.0	COG0682@1|root,COG0682@2|Bacteria,2GKSS@201174|Actinobacteria	201174|Actinobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
SRD2_k127_6974231_3	1382356.JQMP01000003_gene2403	2.04e-165	542.0	COG0322@1|root,COG0322@2|Bacteria,2G651@200795|Chloroflexi,27Y2A@189775|Thermomicrobia	189775|Thermomicrobia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_5,UVR,UvrC_HhH_N
SRD2_k127_6974231_27	146922.JOFU01000015_gene3819	1.434e-08	68.0	COG3170@1|root,COG3170@2|Bacteria,2I40K@201174|Actinobacteria	201174|Actinobacteria	NU	Glycosyltransferase family 87	-	-	-	ko:K13671	-	-	-	-	ko00000,ko01000,ko01003	-	GT87	-	GT87
SRD2_k127_6974231_17	1123242.JH636434_gene4957	8.986e-74	258.0	COG1216@1|root,COG1216@2|Bacteria,2IYBZ@203682|Planctomycetes	203682|Planctomycetes	S	involved in cell wall biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SRD2_k127_6974231_0	635013.TherJR_2732	0.0	1241.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,260NC@186807|Peptococcaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
SRD2_k127_6974231_28	35754.JNYJ01000032_gene1773	2.069e-08	67.0	2A08G@1|root,30NBR@2|Bacteria,2H1QF@201174|Actinobacteria,4DICX@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_7010958_0	1185876.BN8_06323	0.0005852	48.0	COG4953@1|root,COG4953@2|Bacteria,4NEG5@976|Bacteroidetes,47KYC@768503|Cytophagia	976|Bacteroidetes	M	penicillin-binding protein 1C	-	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
SRD2_k127_7016398_1	483219.LILAB_34320	7.169e-33	134.0	COG3335@1|root,COG3335@2|Bacteria	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
SRD2_k127_7016398_0	365044.Pnap_0594	7.471e-56	214.0	COG5659@1|root,COG5659@2|Bacteria,1MXSV@1224|Proteobacteria,2VPGV@28216|Betaproteobacteria,4AD6V@80864|Comamonadaceae	28216|Betaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
SRD2_k127_7016398_2	886293.Sinac_5760	1.66e-25	108.0	COG2197@1|root,COG2197@2|Bacteria,2J3A2@203682|Planctomycetes	203682|Planctomycetes	K	PFAM Bacterial regulatory proteins, luxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE
SRD2_k127_7017433_18	1380370.JIBA01000013_gene1264	1.791e-09	68.0	COG1994@1|root,COG1994@2|Bacteria,2I6W3@201174|Actinobacteria	201174|Actinobacteria	S	Peptidase M50	-	-	-	ko:K16922	-	-	-	-	ko00000,ko01002	-	-	-	-
SRD2_k127_7017433_4	1077972.ARGLB_008_00230	5.758e-111	381.0	COG1994@1|root,COG1994@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	ko:K16922	-	-	-	-	ko00000,ko01002	-	-	-	-
SRD2_k127_7017433_23	1179773.BN6_28450	0.0004293	46.0	2A3EE@1|root,30RX0@2|Bacteria,2IBKW@201174|Actinobacteria,4E9HI@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_7017433_22	1380347.JNII01000005_gene3461	0.0002035	46.0	2A3EE@1|root,30RX0@2|Bacteria,2IBKW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_7017433_8	2002.JOEQ01000002_gene4383	1.581e-82	289.0	COG0258@1|root,COG0258@2|Bacteria,2GKTZ@201174|Actinobacteria,4EIBW@85012|Streptosporangiales	201174|Actinobacteria	L	Helix-hairpin-helix class 2 (Pol1 family) motifs	polA_1	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
SRD2_k127_7017433_13	1283299.AUKG01000001_gene3019	5.549e-62	233.0	COG2267@1|root,COG2267@2|Bacteria,2HFRI@201174|Actinobacteria,4CQZ8@84995|Rubrobacteria	84995|Rubrobacteria	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,SCP2
SRD2_k127_7017433_7	1380390.JIAT01000010_gene3637	1.032e-83	290.0	COG1752@1|root,COG1752@2|Bacteria,2IB0F@201174|Actinobacteria,4CR75@84995|Rubrobacteria	84995|Rubrobacteria	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
SRD2_k127_7017433_0	1380390.JIAT01000010_gene4238	1.13e-215	686.0	COG0318@1|root,COG0318@2|Bacteria,2GKDF@201174|Actinobacteria,4CPC4@84995|Rubrobacteria	84995|Rubrobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
SRD2_k127_7017433_19	983917.RGE_35400	5.643e-08	64.0	COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,2VRTK@28216|Betaproteobacteria,1KIZN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	Belongs to the ParA family	fleN	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	AAA_31,CbiA,ParA
SRD2_k127_7017433_1	765420.OSCT_1890	7.655e-169	548.0	COG1012@1|root,COG1012@2|Bacteria,2G83P@200795|Chloroflexi,3769Y@32061|Chloroflexia	32061|Chloroflexia	C	belongs to the aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_7017433_16	1382356.JQMP01000001_gene772	6.593e-45	179.0	COG4097@1|root,COG4097@2|Bacteria,2G71Y@200795|Chloroflexi,27Z6H@189775|Thermomicrobia	189775|Thermomicrobia	P	Ferric reductase like transmembrane component	-	-	-	-	-	-	-	-	-	-	-	-	Ferric_reduct
SRD2_k127_7017433_14	479434.Sthe_0755	1.43e-58	217.0	COG1477@1|root,COG1477@2|Bacteria,2G6WH@200795|Chloroflexi,27YUM@189775|Thermomicrobia	189775|Thermomicrobia	H	ApbE family	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
SRD2_k127_7017433_5	351607.Acel_1448	1.712e-105	359.0	COG0642@1|root,COG2770@1|root,COG2205@2|Bacteria,COG2770@2|Bacteria,2GIV9@201174|Actinobacteria,4EXEH@85013|Frankiales	201174|Actinobacteria	T	histidine kinase HAMP region domain protein	phoR	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
SRD2_k127_7017433_10	28444.JODQ01000003_gene5062	5.904e-77	269.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4EI79@85012|Streptosporangiales	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	phoP	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
SRD2_k127_7017433_17	215803.DB30_1747	3.181e-36	155.0	COG5276@1|root,COG5276@2|Bacteria	2|Bacteria	-	-	MA20_04930	-	-	-	-	-	-	-	-	-	-	-	LVIVD
SRD2_k127_7017433_6	1120917.AQXM01000049_gene414	2.057e-89	300.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,1W7R4@1268|Micrococcaceae	201174|Actinobacteria	T	response regulator	phoP	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
SRD2_k127_7017433_3	351607.Acel_1448	6.461e-113	381.0	COG0642@1|root,COG2770@1|root,COG2205@2|Bacteria,COG2770@2|Bacteria,2GIV9@201174|Actinobacteria,4EXEH@85013|Frankiales	201174|Actinobacteria	T	histidine kinase HAMP region domain protein	phoR	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
SRD2_k127_7017433_12	749927.AMED_5332	4.727e-66	245.0	COG0265@1|root,COG0265@2|Bacteria,2GJ15@201174|Actinobacteria,4E2YQ@85010|Pseudonocardiales	201174|Actinobacteria	O	Domain present in PSD-95, Dlg, and ZO-1/2.	sprJ	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
SRD2_k127_7017433_2	1095769.CAHF01000011_gene2299	1.834e-118	391.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2VKJJ@28216|Betaproteobacteria,476RE@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
SRD2_k127_7017433_11	675635.Psed_0412	1.921e-67	246.0	COG1721@1|root,COG1721@2|Bacteria,2GKSJ@201174|Actinobacteria,4E03G@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
SRD2_k127_7017433_15	1385520.N802_14465	6.68e-55	208.0	COG2304@1|root,COG2304@2|Bacteria,2GNKP@201174|Actinobacteria,4FGG7@85021|Intrasporangiaceae	201174|Actinobacteria	S	Von Willebrand factor A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA,VWA_2
SRD2_k127_7017433_20	1172188.KB911824_gene3399	5.811e-06	59.0	28JU0@1|root,2Z9J3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_7017433_9	255470.cbdbA734	1.933e-78	270.0	arCOG06481@1|root,2ZB4E@2|Bacteria,2G82Q@200795|Chloroflexi,34CXZ@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_7020559_0	765420.OSCT_1309	1.297e-32	142.0	COG0745@1|root,COG4963@1|root,COG0745@2|Bacteria,COG4963@2|Bacteria,2G89B@200795|Chloroflexi,377XT@32061|Chloroflexia	2|Bacteria	D	Cellulose biosynthesis protein BcsQ	flpE	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CbiA,ParA,Response_reg
SRD2_k127_7026061_7	1396141.BATP01000018_gene1550	8.492e-23	100.0	COG0640@1|root,COG0640@2|Bacteria,46T9N@74201|Verrucomicrobia,2IW9C@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
SRD2_k127_7026061_9	1282360.ABAC460_01530	0.000706	49.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
SRD2_k127_7026061_2	1068978.AMETH_3059	1.213e-112	382.0	COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria,4DZCT@85010|Pseudonocardiales	201174|Actinobacteria	Q	Belongs to the long-chain O-acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,PAP2_3,WES_acyltransf
SRD2_k127_7026061_0	882083.SacmaDRAFT_3025	1.38e-189	607.0	COG1680@1|root,COG1680@2|Bacteria,2I2WV@201174|Actinobacteria,4EDVP@85010|Pseudonocardiales	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SRD2_k127_7026061_3	485913.Krac_10032	5.181e-84	304.0	COG1131@1|root,COG1131@2|Bacteria,2G5QI@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SRD2_k127_7026061_6	1382306.JNIM01000001_gene463	8.592e-31	139.0	COG3559@1|root,COG3559@2|Bacteria,2G7I8@200795|Chloroflexi	200795|Chloroflexi	M	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
SRD2_k127_7026061_1	1160718.SU9_27504	1.724e-182	586.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SRD2_k127_7026061_5	1283283.ATXA01000001_gene375	1.323e-41	156.0	COG3795@1|root,COG3795@2|Bacteria,2IKRD@201174|Actinobacteria,4ET7H@85013|Frankiales	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
SRD2_k127_7026061_4	1356854.N007_02415	3.336e-44	169.0	COG1321@1|root,COG1321@2|Bacteria,1V4V7@1239|Firmicutes,4HI7T@91061|Bacilli	91061|Bacilli	K	Involved in manganese homeostasis. Might activate the transcription of the mntABCD operon	mntR	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
SRD2_k127_7026061_8	106370.Francci3_2368	7.555e-16	79.0	COG0428@1|root,COG0428@2|Bacteria,2IBHZ@201174|Actinobacteria,4ESCI@85013|Frankiales	201174|Actinobacteria	P	ZIP Zinc transporter	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
SRD2_k127_7058532_0	439235.Dalk_1632	3.647e-29	123.0	COG0317@1|root,COG0317@2|Bacteria,1N2BZ@1224|Proteobacteria,430HK@68525|delta/epsilon subdivisions,2WVNF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_4
SRD2_k127_7058532_1	485913.Krac_12061	3.033e-16	87.0	2DRNV@1|root,33CEY@2|Bacteria,2G9RY@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_7058532_2	479433.Caci_7414	3.822e-16	81.0	COG2120@1|root,COG2120@2|Bacteria,2GIUS@201174|Actinobacteria	201174|Actinobacteria	S	PFAM LmbE family protein	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
SRD2_k127_7062756_2	1463920.JOGB01000045_gene2826	6.831e-17	94.0	COG4932@1|root,COG4932@2|Bacteria,2IFAA@201174|Actinobacteria	201174|Actinobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_7062756_0	266117.Rxyl_1110	5.184e-180	576.0	COG0281@1|root,COG0281@2|Bacteria,2GJAJ@201174|Actinobacteria,4CPBI@84995|Rubrobacteria	84995|Rubrobacteria	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	ACT_4,Malic_M,malic
SRD2_k127_7062756_1	446466.Cfla_3282	3.252e-30	133.0	COG0420@1|root,COG0420@2|Bacteria	2|Bacteria	L	3'-5' exonuclease activity	yhaO	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,Metallophos_2
SRD2_k127_7063381_6	469383.Cwoe_5781	4.579e-81	282.0	COG2267@1|root,COG2267@2|Bacteria,2I8F2@201174|Actinobacteria,4CT1E@84995|Rubrobacteria	84995|Rubrobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
SRD2_k127_7063381_3	208439.AJAP_05455	1.951e-140	458.0	COG3243@1|root,COG3243@2|Bacteria,2GP7I@201174|Actinobacteria,4DY42@85010|Pseudonocardiales	201174|Actinobacteria	I	synthetase	-	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6,PHB_depo_C
SRD2_k127_7063381_9	1283299.AUKG01000001_gene1499	6.893e-49	182.0	COG0352@1|root,COG0352@2|Bacteria,2GKCN@201174|Actinobacteria,4CQ70@84995|Rubrobacteria	84995|Rubrobacteria	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	-	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
SRD2_k127_7063381_17	479434.Sthe_1492	5.55e-08	63.0	COG2104@1|root,COG2104@2|Bacteria,2GBFH@200795|Chloroflexi,27ZAZ@189775|Thermomicrobia	189775|Thermomicrobia	H	thiamine biosynthesis protein ThiS	-	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
SRD2_k127_7063381_7	1501230.ET33_07305	4.76e-79	271.0	COG2022@1|root,COG2022@2|Bacteria,1TQZ1@1239|Firmicutes,4HBSI@91061|Bacilli,26QFY@186822|Paenibacillaceae	91061|Bacilli	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG
SRD2_k127_7063381_12	290397.Adeh_4320	1.201e-38	161.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,42MYJ@68525|delta/epsilon subdivisions,2WNGE@28221|Deltaproteobacteria,2YVMB@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
SRD2_k127_7063381_14	644966.Tmar_0266	8.213e-25	110.0	COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,24MSS@186801|Clostridia,3WCKY@538999|Clostridiales incertae sedis	186801|Clostridia	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	ydiB	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
SRD2_k127_7063381_15	748224.HMPREF9436_01634	1.069e-11	74.0	COG1214@1|root,COG1214@2|Bacteria,1V4YX@1239|Firmicutes,24A0P@186801|Clostridia,3WJ9X@541000|Ruminococcaceae	186801|Clostridia	O	Universal bacterial protein YeaZ	yeaZ	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Acetyltransf_1,Peptidase_M22
SRD2_k127_7063381_11	479434.Sthe_0914	1.889e-41	158.0	COG0454@1|root,COG0456@2|Bacteria,2G6TF@200795|Chloroflexi,27Y7H@189775|Thermomicrobia	189775|Thermomicrobia	K	FR47-like protein	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
SRD2_k127_7063381_4	1121468.AUBR01000047_gene1877	4.737e-94	321.0	COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,247MG@186801|Clostridia,42EXJ@68295|Thermoanaerobacterales	186801|Clostridia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
SRD2_k127_7063381_13	485916.Dtox_3373	8.746e-33	130.0	COG0234@1|root,COG0234@2|Bacteria,1V9ZM@1239|Firmicutes,24MMM@186801|Clostridia,262FV@186807|Peptococcaceae	186801|Clostridia	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
SRD2_k127_7063381_0	1382304.JNIL01000001_gene2628	7.342e-220	694.0	COG0459@1|root,COG0459@2|Bacteria,1TP1T@1239|Firmicutes,4HA38@91061|Bacilli,277XH@186823|Alicyclobacillaceae	91061|Bacilli	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0001817,GO:0001819,GO:0001871,GO:0002791,GO:0002793,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009986,GO:0009987,GO:0016465,GO:0030246,GO:0030247,GO:0032677,GO:0032757,GO:0032879,GO:0032880,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044764,GO:0046812,GO:0048518,GO:0048522,GO:0050707,GO:0050708,GO:0050714,GO:0050715,GO:0050789,GO:0050794,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051082,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051704,GO:0061077,GO:0065007,GO:0070201,GO:0090087,GO:0098630,GO:0098743,GO:0101031,GO:1903530,GO:1903532,GO:1904951,GO:1990220,GO:2000482,GO:2000484,GO:2001065	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
SRD2_k127_7063381_8	1132836.RCCGE510_05392	4.278e-62	227.0	COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,2TVCS@28211|Alphaproteobacteria,4BMMH@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
SRD2_k127_7063381_16	42256.RradSPS_0047	1.427e-11	76.0	2DFV5@1|root,2ZT9W@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_7063381_2	552811.Dehly_0900	7.958e-198	652.0	COG0210@1|root,COG0210@2|Bacteria,2G5XF@200795|Chloroflexi,34D7Z@301297|Dehalococcoidia	301297|Dehalococcoidia	L	UvrD/REP helicase N-terminal domain	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
SRD2_k127_7063381_1	42256.RradSPS_0101	5.162e-198	638.0	COG0272@1|root,COG0272@2|Bacteria,2GJUY@201174|Actinobacteria,4CPFU@84995|Rubrobacteria	84995|Rubrobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
SRD2_k127_7063381_5	1278078.G419_20940	7.908e-83	277.0	2DBX9@1|root,2ZBN9@2|Bacteria,2I98J@201174|Actinobacteria,4G1XB@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_7063381_10	710111.FraQA3DRAFT_4238	7.291e-48	179.0	COG1403@1|root,COG1403@2|Bacteria,2GU7G@201174|Actinobacteria,4EV73@85013|Frankiales	201174|Actinobacteria	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
SRD2_k127_7068419_2	575589.HMPREF0018_01728	1.215e-06	54.0	2DBRF@1|root,2ZAKB@2|Bacteria,1N3FC@1224|Proteobacteria,1S6ZF@1236|Gammaproteobacteria,3NP73@468|Moraxellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_7068419_0	1229780.BN381_130262	2.002e-91	310.0	COG1752@1|root,COG1752@2|Bacteria,2GNBM@201174|Actinobacteria	201174|Actinobacteria	K	Esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
SRD2_k127_7068419_1	1079986.JH164861_gene7179	6.691e-52	192.0	COG2345@1|root,COG2345@2|Bacteria,2HCEF@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
SRD2_k127_7089121_0	498761.HM1_1370	1.167e-263	828.0	COG0085@1|root,COG0085@2|Bacteria,1TP96@1239|Firmicutes,247J1@186801|Clostridia	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
SRD2_k127_7096420_3	290397.Adeh_4141	6.149e-24	109.0	COG0586@1|root,COG0586@2|Bacteria	2|Bacteria	S	FtsZ-dependent cytokinesis	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
SRD2_k127_7096420_1	1449976.KALB_2239	8.415e-90	308.0	COG1024@1|root,COG1024@2|Bacteria,2GKJ6@201174|Actinobacteria,4DYKR@85010|Pseudonocardiales	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
SRD2_k127_7096420_4	640512.BC1003_0766	1.17e-20	107.0	2AHB9@1|root,317MQ@2|Bacteria,1PYZ8@1224|Proteobacteria,2WE3A@28216|Betaproteobacteria,1KBIU@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
SRD2_k127_7096420_2	909613.UO65_3006	1.827e-80	284.0	COG2326@1|root,COG2326@2|Bacteria,2GKRN@201174|Actinobacteria,4E2C2@85010|Pseudonocardiales	201174|Actinobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
SRD2_k127_7096420_0	469383.Cwoe_0202	5.637e-112	376.0	COG2124@1|root,COG2124@2|Bacteria,2GK4Z@201174|Actinobacteria,4CPQ8@84995|Rubrobacteria	84995|Rubrobacteria	Q	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
SRD2_k127_7096420_5	324602.Caur_1003	1.718e-17	85.0	COG1122@1|root,COG1122@2|Bacteria,2G6FK@200795|Chloroflexi,37779@32061|Chloroflexia	32061|Chloroflexia	P	ECF transporter, substrate-specific component	-	-	-	ko:K16927	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.32	-	-	ECF_trnsprt
SRD2_k127_7097302_0	309801.trd_1890	1.888e-131	443.0	COG0008@1|root,COG0008@2|Bacteria,2G5WU@200795|Chloroflexi,27XPN@189775|Thermomicrobia	189775|Thermomicrobia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
SRD2_k127_7097302_1	208444.JNYY01000005_gene6331	1.508e-46	189.0	COG2072@1|root,COG2072@2|Bacteria,2GNGX@201174|Actinobacteria,4E165@85010|Pseudonocardiales	201174|Actinobacteria	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_3
SRD2_k127_7097302_2	215803.DB30_3013	5.532e-11	68.0	COG0664@1|root,COG3264@1|root,COG0664@2|Bacteria,COG3264@2|Bacteria,1QX62@1224|Proteobacteria,42S57@68525|delta/epsilon subdivisions,2WNY0@28221|Deltaproteobacteria,2YVPP@29|Myxococcales	28221|Deltaproteobacteria	MT	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel,cNMP_binding
SRD2_k127_7109412_3	398767.Glov_2453	2.592e-38	146.0	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,42P8R@68525|delta/epsilon subdivisions,2WKIR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Methyltrn_RNA_4,tRNA_m1G_MT
SRD2_k127_7109412_2	699218.HMPREF0889_1045	6.841e-39	153.0	COG0335@1|root,COG0335@2|Bacteria,1V6FT@1239|Firmicutes,4H4PC@909932|Negativicutes	909932|Negativicutes	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
SRD2_k127_7109412_1	1120973.AQXL01000128_gene2883	3.766e-56	213.0	COG0164@1|root,COG0164@2|Bacteria,1V1D6@1239|Firmicutes,4HB7M@91061|Bacilli,278C3@186823|Alicyclobacillaceae	91061|Bacilli	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
SRD2_k127_7109412_4	313589.JNB_19818	4.778e-21	96.0	COG0792@1|root,COG0792@2|Bacteria,2IQ3X@201174|Actinobacteria,4FHNM@85021|Intrasporangiaceae	201174|Actinobacteria	L	Belongs to the UPF0102 family	yraN	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
SRD2_k127_7109412_0	552398.HMPREF0866_00247	2.145e-58	210.0	COG0606@1|root,COG0606@2|Bacteria,1TPPB@1239|Firmicutes,248T8@186801|Clostridia,3WH36@541000|Ruminococcaceae	186801|Clostridia	O	chelatase subunit ChlI	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
SRD2_k127_7116349_0	886293.Sinac_6373	4.389e-136	437.0	COG0449@1|root,COG0449@2|Bacteria,2IXF9@203682|Planctomycetes	203682|Planctomycetes	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
SRD2_k127_7116349_2	1499967.BAYZ01000083_gene1026	1.764e-29	134.0	COG3599@1|root,COG3599@2|Bacteria	2|Bacteria	D	regulation of cell shape	-	-	-	ko:K04074,ko:K07484	-	-	-	-	ko00000,ko03036	-	-	-	DDE_Tnp_IS66,DivIVA,zf-IS66
SRD2_k127_7129266_0	1210884.HG799464_gene10943	5.358e-78	266.0	COG3293@1|root,COG3293@2|Bacteria,2IX9I@203682|Planctomycetes	203682|Planctomycetes	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4096
SRD2_k127_7129266_1	314230.DSM3645_28117	7.075e-17	81.0	COG3293@1|root,COG3293@2|Bacteria,2IX9I@203682|Planctomycetes	203682|Planctomycetes	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4096
SRD2_k127_7129266_2	1500890.JQNL01000001_gene2920	3.503e-11	70.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,1RN7I@1236|Gammaproteobacteria,1X7J6@135614|Xanthomonadales	135614|Xanthomonadales	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
SRD2_k127_7132838_1	479434.Sthe_2544	3.75e-81	283.0	COG0477@1|root,COG2211@1|root,COG0477@2|Bacteria,COG2211@2|Bacteria,2G5J9@200795|Chloroflexi,27Y0E@189775|Thermomicrobia	189775|Thermomicrobia	P	Fungal trichothecene efflux pump (TRI12)	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SRD2_k127_7132838_2	330084.JNYZ01000032_gene5549	7.592e-38	148.0	COG1832@1|root,COG1832@2|Bacteria,2IHSP@201174|Actinobacteria,4E51X@85010|Pseudonocardiales	201174|Actinobacteria	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
SRD2_k127_7132838_0	1394178.AWOO02000103_gene5698	1.533e-167	552.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,4EG9Z@85012|Streptosporangiales	201174|Actinobacteria	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
SRD2_k127_7132838_3	1502852.FG94_02000	8.172e-25	109.0	COG0454@1|root,COG0456@2|Bacteria,1MYCM@1224|Proteobacteria,2W5IR@28216|Betaproteobacteria	28216|Betaproteobacteria	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SRD2_k127_7136424_6	1123253.AUBD01000001_gene1857	3.576e-15	77.0	COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,1RNWH@1236|Gammaproteobacteria,1X413@135614|Xanthomonadales	135614|Xanthomonadales	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07665	ko02020,map02020	M00452,M00745	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
SRD2_k127_7136424_2	330214.NIDE0304	1.064e-55	214.0	COG5000@1|root,COG5002@1|root,COG5000@2|Bacteria,COG5002@2|Bacteria,3J11K@40117|Nitrospirae	40117|Nitrospirae	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
SRD2_k127_7136424_1	330214.NIDE3718	2.244e-99	338.0	COG0451@1|root,COG0451@2|Bacteria,3J12G@40117|Nitrospirae	40117|Nitrospirae	M	Polysaccharide biosynthesis protein	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
SRD2_k127_7136424_3	56780.SYN_02721	1.121e-52	208.0	COG2206@1|root,COG5000@1|root,COG2206@2|Bacteria,COG5000@2|Bacteria,1RAQS@1224|Proteobacteria,42MEJ@68525|delta/epsilon subdivisions,2X71A@28221|Deltaproteobacteria,2MSKQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HAMP,HD,HD_5
SRD2_k127_7136424_4	1411123.JQNH01000001_gene2071	3.02e-43	168.0	COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2TU4V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.1.1.41,4.2.1.17	ko:K01692,ko:K11264	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R00923,R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00097,RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
SRD2_k127_7136424_5	35754.JNYJ01000007_gene2876	1.14e-18	87.0	COG4770@1|root,COG4770@2|Bacteria,2I2DF@201174|Actinobacteria,4DFRH@85008|Micromonosporales	201174|Actinobacteria	I	Biotin lipoyl attachment domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
SRD2_k127_7136424_0	1313301.AUGC01000013_gene1249	4.092e-109	361.0	COG3246@1|root,COG3246@2|Bacteria,4NGNQ@976|Bacteroidetes	976|Bacteroidetes	S	3-keto-5-aminohexanoate cleavage protein	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
SRD2_k127_7166592_1	1206731.BAGB01000170_gene4488	1.477e-34	140.0	COG0586@1|root,COG0586@2|Bacteria,2GN43@201174|Actinobacteria,4FUAR@85025|Nocardiaceae	201174|Actinobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
SRD2_k127_7166592_0	479434.Sthe_1887	1.261e-52	192.0	COG0077@1|root,COG0077@2|Bacteria,2G6AP@200795|Chloroflexi,27XFH@189775|Thermomicrobia	189775|Thermomicrobia	E	Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
SRD2_k127_7176843_2	42256.RradSPS_1042	3.963e-11	70.0	COG4118@1|root,COG4118@2|Bacteria,2HRUG@201174|Actinobacteria,4CTXW@84995|Rubrobacteria	84995|Rubrobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
SRD2_k127_7176843_0	1246448.ANAZ01000043_gene1283	1.76e-264	821.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4EG29@85012|Streptosporangiales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
SRD2_k127_7176843_1	1173027.Mic7113_1316	2.419e-11	71.0	COG0477@1|root,COG2814@2|Bacteria,1G2WB@1117|Cyanobacteria,1H7X9@1150|Oscillatoriales	1117|Cyanobacteria	EGP	PFAM Major Facilitator Superfamily	-	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1
SRD2_k127_7239165_0	926566.Terro_1815	1.129e-06	63.0	COG3386@1|root,COG3386@2|Bacteria,3Y3S3@57723|Acidobacteria,2JIBP@204432|Acidobacteriia	204432|Acidobacteriia	G	PFAM NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,NHL
SRD2_k127_7254273_4	1232410.KI421413_gene734	1.227e-07	62.0	COG3745@1|root,COG3745@2|Bacteria,1MW75@1224|Proteobacteria,42S07@68525|delta/epsilon subdivisions,2WNR0@28221|Deltaproteobacteria,43UG0@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	Flp pilus assembly protein RcpC/CpaB	-	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	ChapFlgA,RcpC,SAF
SRD2_k127_7254273_2	326427.Cagg_3211	3.981e-46	183.0	COG4965@1|root,COG4965@2|Bacteria,2G6GS@200795|Chloroflexi,3755T@32061|Chloroflexia	32061|Chloroflexia	U	PFAM type II secretion system protein	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
SRD2_k127_7254273_3	370438.PTH_1453	2.589e-44	175.0	COG2064@1|root,COG2064@2|Bacteria,1V2T1@1239|Firmicutes,24GQ4@186801|Clostridia,261D6@186807|Peptococcaceae	186801|Clostridia	NU	PFAM type II secretion system	tadC	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
SRD2_k127_7254273_0	136273.GY22_16135	3.973e-137	456.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,1WANZ@1268|Micrococcaceae	201174|Actinobacteria	U	Secretion system protein	flpF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
SRD2_k127_7254273_1	1230476.C207_01739	2.627e-68	254.0	COG2114@1|root,COG2114@2|Bacteria,1ND4Q@1224|Proteobacteria,2U51W@28211|Alphaproteobacteria,3JW0V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	DUF2652,Polyketide_cyc2
SRD2_k127_7259156_7	44060.JODL01000021_gene4822	4.178e-62	220.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SRD2_k127_7259156_2	1121272.KB903249_gene1622	1.546e-147	470.0	COG0708@1|root,COG0708@2|Bacteria,2GKEW@201174|Actinobacteria,4D92U@85008|Micromonosporales	201174|Actinobacteria	L	exodeoxyribonuclease III	xthA	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
SRD2_k127_7259156_3	110319.CF8_2173	2.565e-134	445.0	COG5276@1|root,COG5276@2|Bacteria,2I9VY@201174|Actinobacteria	201174|Actinobacteria	S	repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
SRD2_k127_7259156_14	1280954.HPO_14866	7.353e-08	64.0	COG0640@1|root,COG0640@2|Bacteria,1RGYC@1224|Proteobacteria,2UA77@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	arsR family	MA20_01010	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
SRD2_k127_7259156_6	1282876.BAOK01000002_gene676	6.97e-79	275.0	COG1028@1|root,COG1028@2|Bacteria,1R4BJ@1224|Proteobacteria,2U1Q1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	MA20_10020	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
SRD2_k127_7259156_10	2074.JNYD01000030_gene6620	1.583e-43	167.0	COG2128@1|root,COG2128@2|Bacteria,2IS0M@201174|Actinobacteria,4EEYP@85010|Pseudonocardiales	201174|Actinobacteria	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
SRD2_k127_7259156_8	1196028.ALEF01000042_gene621	1.811e-53	211.0	COG2936@1|root,COG2936@2|Bacteria,1TT78@1239|Firmicutes,4HBA0@91061|Bacilli,4C65M@84406|Virgibacillus	91061|Bacilli	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	pepX	-	3.4.14.11	ko:K01281	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PepX_C,PepX_N,Peptidase_S15
SRD2_k127_7259156_4	1206741.BAFX01000064_gene5041	2.895e-124	419.0	COG3511@1|root,COG3511@2|Bacteria,2GKPN@201174|Actinobacteria,4FV9U@85025|Nocardiaceae	201174|Actinobacteria	M	COG3511 Phospholipase C	plc	GO:0003674,GO:0003824,GO:0004620,GO:0004629,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006629,GO:0008081,GO:0008150,GO:0008152,GO:0009056,GO:0009405,GO:0016020,GO:0016042,GO:0016298,GO:0016787,GO:0016788,GO:0034480,GO:0035821,GO:0042578,GO:0044003,GO:0044238,GO:0044403,GO:0044419,GO:0044464,GO:0051701,GO:0051704,GO:0051817,GO:0052008,GO:0052043,GO:0052111,GO:0052185,GO:0052188,GO:0052368,GO:0071704,GO:0071944,GO:1901575	3.1.4.3	ko:K01114	ko00562,ko00564,ko00565,ko01100,ko01110,ko02024,ko04919,map00562,map00564,map00565,map01100,map01110,map02024,map04919	-	R01312,R02027,R02052,R03332,R07381	RC00017,RC00425	ko00000,ko00001,ko01000,ko02042	-	-	iNJ661.Rv1755c	Phosphoesterase
SRD2_k127_7259156_0	749414.SBI_08391	1.035e-279	867.0	COG3573@1|root,COG3573@2|Bacteria,2GIYM@201174|Actinobacteria	201174|Actinobacteria	S	Dehydrogenase	-	-	-	ko:K07077	-	-	-	-	ko00000	-	-	-	FAD_binding_2
SRD2_k127_7259156_9	208444.JNYY01000004_gene2076	3.165e-46	179.0	COG2755@1|root,COG2755@2|Bacteria,2GYQF@201174|Actinobacteria	201174|Actinobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
SRD2_k127_7259156_1	639030.JHVA01000001_gene1853	7.782e-219	682.0	COG4447@1|root,COG4447@2|Bacteria,3Y3TM@57723|Acidobacteria,2JHSZ@204432|Acidobacteriia	204432|Acidobacteriia	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
SRD2_k127_7259156_12	1394178.AWOO02000071_gene381	2.637e-32	131.0	COG1977@1|root,COG1977@2|Bacteria,2IQJJ@201174|Actinobacteria,4EPKG@85012|Streptosporangiales	201174|Actinobacteria	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	-	-	-	-	-	-	-	-	-	-	-	-	ThiS
SRD2_k127_7259156_5	1298863.AUEP01000001_gene785	1.005e-88	322.0	COG4585@1|root,COG4585@2|Bacteria,2GMMU@201174|Actinobacteria,4DV3H@85009|Propionibacteriales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
SRD2_k127_7259156_11	857293.CAAU_0749	8.685e-37	158.0	COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1TQ94@1239|Firmicutes,248BK@186801|Clostridia,36EBF@31979|Clostridiaceae	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,EAL,GGDEF
SRD2_k127_7259156_13	1382356.JQMP01000003_gene2233	2.409e-10	63.0	COG2071@1|root,COG2071@2|Bacteria,2G6QN@200795|Chloroflexi,27YBG@189775|Thermomicrobia	189775|Thermomicrobia	S	Peptidase C26	-	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
SRD2_k127_7279880_0	869210.Marky_1176	3.252e-56	199.0	COG1225@1|root,COG1225@2|Bacteria,1WI9E@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
SRD2_k127_7279880_3	1267533.KB906737_gene1631	1.996e-34	136.0	COG0314@1|root,COG1977@1|root,COG0314@2|Bacteria,COG1977@2|Bacteria,3Y519@57723|Acidobacteria,2JMGK@204432|Acidobacteriia	204432|Acidobacteriia	H	MoaE protein	-	-	2.8.1.12	ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE,ThiS
SRD2_k127_7279880_4	483219.LILAB_20495	9.747e-12	68.0	COG0314@1|root,COG1977@1|root,COG0314@2|Bacteria,COG1977@2|Bacteria,1RGUX@1224|Proteobacteria,437BZ@68525|delta/epsilon subdivisions,2WQNB@28221|Deltaproteobacteria,2YVJC@29|Myxococcales	28221|Deltaproteobacteria	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	moaD	-	2.8.1.12	ko:K03635,ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE,ThiS
SRD2_k127_7279880_1	929712.KI912613_gene4355	5.27e-51	198.0	COG0644@1|root,COG0644@2|Bacteria,2HQ8K@201174|Actinobacteria,4CRS9@84995|Rubrobacteria	84995|Rubrobacteria	C	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_7279880_2	1382306.JNIM01000001_gene1590	7.848e-36	145.0	COG2096@1|root,COG2096@2|Bacteria,2G6TB@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Cobalamin adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
SRD2_k127_7292508_3	1123288.SOV_1c08260	4.272e-76	267.0	COG0772@1|root,COG0772@2|Bacteria,1TPGH@1239|Firmicutes,4H21I@909932|Negativicutes	909932|Negativicutes	M	Peptidoglycan polymerase that is essential for cell wall elongation	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
SRD2_k127_7292508_2	401526.TcarDRAFT_0739	1.171e-111	389.0	COG0768@1|root,COG0768@2|Bacteria,1TQHY@1239|Firmicutes,4H241@909932|Negativicutes	909932|Negativicutes	M	PFAM penicillin-binding protein transpeptidase	-	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
SRD2_k127_7292508_7	926550.CLDAP_08150	1.659e-11	71.0	COG2891@1|root,COG2891@2|Bacteria	2|Bacteria	M	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins	mreD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
SRD2_k127_7292508_6	675812.VHA_000846	2.825e-25	115.0	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,1RMK4@1236|Gammaproteobacteria,1XSEQ@135623|Vibrionales	135623|Vibrionales	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
SRD2_k127_7292508_1	635013.TherJR_2546	3.643e-136	443.0	COG1077@1|root,COG1077@2|Bacteria,1TP51@1239|Firmicutes,247RG@186801|Clostridia,260KS@186807|Peptococcaceae	186801|Clostridia	D	TIGRFAM Cell shape determining protein MreB Mrl	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
SRD2_k127_7292508_4	1064535.MELS_1579	1.06e-38	155.0	COG0424@1|root,COG0424@2|Bacteria,1V6FH@1239|Firmicutes,4H4NK@909932|Negativicutes	909932|Negativicutes	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
SRD2_k127_7292508_10	1906.SFRA_21185	0.0001685	54.0	COG0651@1|root,COG0651@2|Bacteria,2HAC7@201174|Actinobacteria	201174|Actinobacteria	CP	Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
SRD2_k127_7292508_5	326427.Cagg_2942	1.449e-28	122.0	COG0143@1|root,COG0143@2|Bacteria,2G6VG@200795|Chloroflexi,375Q2@32061|Chloroflexia	32061|Chloroflexia	J	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	DZR
SRD2_k127_7292508_0	477974.Daud_1473	1.349e-240	773.0	COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,248VC@186801|Clostridia,25ZYN@186807|Peptococcaceae	186801|Clostridia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
SRD2_k127_7292508_9	455632.SGR_2370	3.232e-06	58.0	2EDJR@1|root,337FI@2|Bacteria,2GIRI@201174|Actinobacteria,419K7@629295|Streptomyces griseus group	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_7355518_1	479434.Sthe_0930	4.793e-242	765.0	COG1111@1|root,COG1205@1|root,COG1111@2|Bacteria,COG1205@2|Bacteria,2G7WU@200795|Chloroflexi,27YR8@189775|Thermomicrobia	189775|Thermomicrobia	L	helicase superfamily c-terminal domain	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
SRD2_k127_7355518_33	1121406.JAEX01000005_gene2988	1.697e-31	131.0	COG1437@1|root,COG1437@2|Bacteria,1N326@1224|Proteobacteria,42U83@68525|delta/epsilon subdivisions,2WQQR@28221|Deltaproteobacteria,2MBY3@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	PFAM Adenylate cyclase	-	-	4.6.1.1	ko:K05873	ko00230,map00230	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	CYTH
SRD2_k127_7355518_41	1108045.GORHZ_030_00020	3.067e-12	74.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,2GN50@201174|Actinobacteria,4GECX@85026|Gordoniaceae	201174|Actinobacteria	P	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
SRD2_k127_7355518_4	1303518.CCALI_00259	7.843e-163	519.0	COG0473@1|root,COG0473@2|Bacteria	2|Bacteria	CE	3-isopropylmalate dehydrogenase activity	icd	-	1.1.1.41	ko:K00030	ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00709	RC00114	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
SRD2_k127_7355518_15	485913.Krac_11137	6.531e-95	328.0	COG2309@1|root,COG2309@2|Bacteria	2|Bacteria	E	aminopeptidase activity	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
SRD2_k127_7355518_3	1128421.JAGA01000003_gene3666	4.627e-169	537.0	COG0473@1|root,COG0473@2|Bacteria	2|Bacteria	CE	3-isopropylmalate dehydrogenase activity	icd	-	1.1.1.41,1.1.1.85	ko:K00030,ko:K00052	ko00020,ko00290,ko00660,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00290,map00660,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00432,M00535	R00709,R00994,R04426,R10052	RC00084,RC00114,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
SRD2_k127_7355518_35	1121413.JMKT01000009_gene2170	1.956e-28	116.0	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,42TRU@68525|delta/epsilon subdivisions,2WPZK@28221|Deltaproteobacteria,2MCF7@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
SRD2_k127_7355518_11	926550.CLDAP_12660	8.082e-116	380.0	COG0320@1|root,COG0320@2|Bacteria,2G5MH@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
SRD2_k127_7355518_12	479434.Sthe_3475	3.365e-111	383.0	COG0508@1|root,COG0508@2|Bacteria,2G7SG@200795|Chloroflexi,27XXQ@189775|Thermomicrobia	189775|Thermomicrobia	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	-	-	2.3.1.168	ko:K09699	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R02662,R03174,R04097,R10998	RC00004,RC02727,RC02870	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
SRD2_k127_7355518_8	1220589.CD32_20000	3.684e-140	452.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,4HAP6@91061|Bacilli,3IX5Q@400634|Lysinibacillus	91061|Bacilli	C	2-oxoisovalerate dehydrogenase	bfmBAB	-	1.2.4.4	ko:K00167,ko:K21417	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU24040	Transket_pyr,Transketolase_C
SRD2_k127_7355518_10	479434.Sthe_3477	2.85e-117	387.0	COG1071@1|root,COG1071@2|Bacteria,2GAC3@200795|Chloroflexi,27Z5H@189775|Thermomicrobia	189775|Thermomicrobia	C	Dehydrogenase E1 component	-	-	1.2.4.4	ko:K00166	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
SRD2_k127_7355518_7	1157490.EL26_15645	3.119e-148	484.0	COG1249@1|root,COG1249@2|Bacteria,1TP1W@1239|Firmicutes,4H9Z5@91061|Bacilli,278U0@186823|Alicyclobacillaceae	91061|Bacilli	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	bfmBC	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
SRD2_k127_7355518_23	760568.Desku_0594	1.799e-59	223.0	COG0793@1|root,COG0793@2|Bacteria,1TPBI@1239|Firmicutes,248HZ@186801|Clostridia,2601U@186807|Peptococcaceae	186801|Clostridia	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Cu_amine_oxidN1,PDZ,PDZ_2,Peptidase_S41
SRD2_k127_7355518_32	742743.HMPREF9453_00602	7.499e-39	160.0	COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,4H1XM@909932|Negativicutes	909932|Negativicutes	D	Peptidase M23	envC_1	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
SRD2_k127_7355518_31	1121468.AUBR01000012_gene2553	1.4e-42	169.0	COG2177@1|root,COG2177@2|Bacteria,1TPND@1239|Firmicutes,24AA6@186801|Clostridia,42FMA@68295|Thermoanaerobacterales	186801|Clostridia	D	Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
SRD2_k127_7355518_17	986075.CathTA2_1704	1.084e-79	278.0	COG2884@1|root,COG2884@2|Bacteria,1TP58@1239|Firmicutes,4H9Z2@91061|Bacilli	91061|Bacilli	D	cell division ATP-binding protein FtsE	ftsE	GO:0000910,GO:0005575,GO:0005623,GO:0005886,GO:0007049,GO:0008150,GO:0008356,GO:0009966,GO:0009987,GO:0010646,GO:0016020,GO:0016043,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0032506,GO:0042173,GO:0043937,GO:0043938,GO:0044085,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0051301,GO:0065007,GO:0070297,GO:0071840,GO:0071944,GO:0090529,GO:1902531	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
SRD2_k127_7355518_47	926569.ANT_18400	0.0003287	53.0	COG1287@1|root,COG1287@2|Bacteria,2G785@200795|Chloroflexi	200795|Chloroflexi	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_7355518_13	273068.TTE0523	5.425e-104	349.0	COG1186@1|root,COG1186@2|Bacteria,1TPSB@1239|Firmicutes,247KU@186801|Clostridia,42EU5@68295|Thermoanaerobacterales	186801|Clostridia	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
SRD2_k127_7355518_0	748449.Halha_2230	1.057e-256	821.0	COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,247N2@186801|Clostridia,3WAH3@53433|Halanaerobiales	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
SRD2_k127_7355518_28	1089548.KI783301_gene809	1.579e-50	205.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,1TRE5@1239|Firmicutes,4IUDA@91061|Bacilli	91061|Bacilli	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_7355518_21	1120944.JONS01000061_gene2578	3.555e-60	216.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4D35T@85005|Actinomycetales	201174|Actinobacteria	V	ABC transporter, ATP-binding protein	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SRD2_k127_7355518_40	663278.Ethha_2190	3.132e-13	81.0	COG2340@1|root,COG2340@2|Bacteria,1V6GZ@1239|Firmicutes,24BAQ@186801|Clostridia,3WJQ5@541000|Ruminococcaceae	186801|Clostridia	M	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP,LysM
SRD2_k127_7355518_6	309801.trd_1011	1.255e-148	479.0	COG4962@1|root,COG4962@2|Bacteria,2G68E@200795|Chloroflexi,27XTR@189775|Thermomicrobia	189775|Thermomicrobia	U	Type II/IV secretion system protein	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
SRD2_k127_7355518_34	765420.OSCT_0519	8.432e-29	128.0	COG1040@1|root,COG1040@2|Bacteria,2G6WB@200795|Chloroflexi,377AQ@32061|Chloroflexia	32061|Chloroflexia	S	competence protein	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
SRD2_k127_7355518_38	525904.Tter_1046	2.336e-23	108.0	COG1430@1|root,COG1430@2|Bacteria,2NRTQ@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
SRD2_k127_7355518_20	383372.Rcas_1680	6.563e-66	236.0	COG2064@1|root,COG2064@2|Bacteria,2G6CF@200795|Chloroflexi,3766N@32061|Chloroflexia	32061|Chloroflexia	NU	PFAM type II secretion system protein	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
SRD2_k127_7355518_27	1128421.JAGA01000002_gene597	2.034e-52	196.0	COG4965@1|root,COG4965@2|Bacteria,2NR3Q@2323|unclassified Bacteria	2|Bacteria	U	Type II secretion system (T2SS), protein F	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
SRD2_k127_7355518_5	1121428.DESHY_10184___1	2.403e-162	525.0	COG4962@1|root,COG4962@2|Bacteria,1TQ0Z@1239|Firmicutes,249VS@186801|Clostridia,2612R@186807|Peptococcaceae	186801|Clostridia	U	type II secretion system protein E	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
SRD2_k127_7355518_18	326427.Cagg_3209	1.485e-78	282.0	COG4753@1|root,COG4963@1|root,COG4753@2|Bacteria,COG4963@2|Bacteria,2G6CH@200795|Chloroflexi,37524@32061|Chloroflexia	32061|Chloroflexia	D	PFAM response regulator receiver	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,ParA,Response_reg
SRD2_k127_7355518_42	994573.T472_0206660	2.398e-11	73.0	COG3745@1|root,COG3745@2|Bacteria,1V5FZ@1239|Firmicutes,24I7V@186801|Clostridia,36P2M@31979|Clostridiaceae	186801|Clostridia	U	Flp pilus assembly protein RcpC/CpaB	-	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	LysM,RcpC,SAF
SRD2_k127_7355518_45	383372.Rcas_1121	4.38e-08	57.0	COG3847@1|root,COG3847@2|Bacteria,2GB1R@200795|Chloroflexi,377RD@32061|Chloroflexia	32061|Chloroflexia	U	PFAM Flp Fap pilin component	-	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Flp_Fap
SRD2_k127_7355518_26	1122915.AUGY01000022_gene6730	3.259e-53	204.0	COG4585@1|root,COG4585@2|Bacteria,1TQI3@1239|Firmicutes,4HAUU@91061|Bacilli,26T94@186822|Paenibacillaceae	91061|Bacilli	T	Member of the two-component regulatory system DegS DegU, which plays an important role in the transition growth phase	degS	-	2.7.13.3	ko:K07777	ko02020,map02020	M00478	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DegS,HATPase_c,HisKA_3
SRD2_k127_7355518_37	335543.Sfum_1486	2.164e-25	114.0	COG2020@1|root,COG2020@2|Bacteria,1PK62@1224|Proteobacteria,43A9T@68525|delta/epsilon subdivisions,2X9S8@28221|Deltaproteobacteria,2MSDY@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	PFAM Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
SRD2_k127_7355518_44	298655.KI912266_gene3675	2.194e-09	70.0	2B0YS@1|root,31TBU@2|Bacteria,2GPJZ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	GT87
SRD2_k127_7355518_43	383372.Rcas_0205	7.108e-10	72.0	COG5650@1|root,COG5650@2|Bacteria,2GA90@200795|Chloroflexi,377SR@32061|Chloroflexia	32061|Chloroflexia	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
SRD2_k127_7355518_29	926569.ANT_26880	9.696e-49	193.0	COG1287@1|root,COG1287@2|Bacteria,2G8T3@200795|Chloroflexi	200795|Chloroflexi	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_7355518_39	926569.ANT_18380	6.842e-22	111.0	COG1287@1|root,COG1287@2|Bacteria,2G785@200795|Chloroflexi	200795|Chloroflexi	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_7355518_19	338963.Pcar_1758	4.967e-70	246.0	COG1215@1|root,COG1215@2|Bacteria,1RJNP@1224|Proteobacteria,42ST7@68525|delta/epsilon subdivisions,2X7KP@28221|Deltaproteobacteria,43V18@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SRD2_k127_7355518_22	926569.ANT_26880	9.158e-60	229.0	COG1287@1|root,COG1287@2|Bacteria,2G8T3@200795|Chloroflexi	200795|Chloroflexi	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_7355518_30	1150864.MILUP08_40457	3.49e-43	162.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,2GKU1@201174|Actinobacteria,4DCN1@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like,PfkB
SRD2_k127_7355518_24	485913.Krac_8465	2.011e-58	211.0	COG1922@1|root,COG1922@2|Bacteria,2G6J0@200795|Chloroflexi	200795|Chloroflexi	M	Belongs to the glycosyltransferase 26 family	-	-	2.4.1.187	ko:K05946	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB
SRD2_k127_7355518_25	1382306.JNIM01000001_gene649	6.218e-57	212.0	COG0859@1|root,COG0859@2|Bacteria,2G8MX@200795|Chloroflexi	200795|Chloroflexi	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
SRD2_k127_7355518_16	641491.DND132_0735	1.085e-90	306.0	COG0588@1|root,COG0588@2|Bacteria,1MUVE@1224|Proteobacteria,42PJM@68525|delta/epsilon subdivisions,2WKJN@28221|Deltaproteobacteria,2M970@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily	gpmA	GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
SRD2_k127_7355518_9	867845.KI911784_gene2607	1.023e-125	414.0	COG1077@1|root,COG1077@2|Bacteria,2G5KV@200795|Chloroflexi,374UP@32061|Chloroflexia	32061|Chloroflexia	D	TIGRFAM cell shape determining protein, MreB Mrl family	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
SRD2_k127_7355518_14	742821.HMPREF9464_01750	1.026e-102	354.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2VHZN@28216|Betaproteobacteria,4PQJC@995019|Sutterellaceae	28216|Betaproteobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
SRD2_k127_7355518_36	1121935.AQXX01000065_gene1686	4.219e-27	115.0	COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,1S25H@1236|Gammaproteobacteria,1XK0R@135619|Oceanospirillales	135619|Oceanospirillales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
SRD2_k127_7355518_2	350688.Clos_2560	1.164e-211	669.0	COG0055@1|root,COG0055@2|Bacteria,1TPGF@1239|Firmicutes,2489W@186801|Clostridia,36ERS@31979|Clostridiaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
SRD2_k127_7355518_46	1379698.RBG1_1C00001G0152	4.886e-06	48.0	COG0224@1|root,COG0224@2|Bacteria,2NP76@2323|unclassified Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iLJ478.TM1611,iSSON_1240.SSON_3886,iYL1228.KPN_04138	ATP-synt
SRD2_k127_7359245_1	43354.JOIJ01000007_gene1434	1.156e-89	299.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,4E11C@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SRD2_k127_7359245_0	1127134.NOCYR_3410	2.118e-125	421.0	COG3559@1|root,COG3559@2|Bacteria,2GMSI@201174|Actinobacteria,4FU1D@85025|Nocardiaceae	201174|Actinobacteria	M	ABC transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
SRD2_k127_7359245_2	1146883.BLASA_5012	4.15e-47	183.0	COG1403@1|root,COG1403@2|Bacteria,2GU7G@201174|Actinobacteria,4EV73@85013|Frankiales	201174|Actinobacteria	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
SRD2_k127_7364547_3	273116.14325660	2.366e-26	109.0	COG0247@1|root,arCOG00332@2157|Archaea,2XTPG@28890|Euryarchaeota,242AB@183967|Thermoplasmata	183967|Thermoplasmata	C	Nitrate reductase gamma subunit	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8,Nitrate_red_gam
SRD2_k127_7364547_1	67275.JOAP01000008_gene4153	6.963e-37	147.0	COG0247@1|root,COG0247@2|Bacteria,2GJ7M@201174|Actinobacteria	201174|Actinobacteria	C	Fe-S oxidoreductase	fadF	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
SRD2_k127_7364547_0	1380390.JIAT01000010_gene3637	2.369e-66	241.0	COG1752@1|root,COG1752@2|Bacteria,2IB0F@201174|Actinobacteria,4CR75@84995|Rubrobacteria	84995|Rubrobacteria	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
SRD2_k127_7364547_2	866895.HBHAL_4047	1.741e-34	148.0	COG0745@1|root,COG2203@1|root,COG5000@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG5000@2|Bacteria,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4HA52@91061|Bacilli,3NDTB@45667|Halobacillus	91061|Bacilli	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_9,Response_reg
SRD2_k127_7364547_4	266117.Rxyl_0007	4.504e-15	89.0	COG1432@1|root,COG1432@2|Bacteria,2HB6H@201174|Actinobacteria	201174|Actinobacteria	NU	OST-HTH/LOTUS domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
SRD2_k127_7464990_0	1382306.JNIM01000001_gene664	9.454e-80	274.0	COG0215@1|root,COG0215@2|Bacteria,2G5Z0@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	-	-	-	-	-	-	-	-	-	-	tRNA-synt_1e
SRD2_k127_7464990_1	1192034.CAP_7183	8.478e-30	130.0	COG2303@1|root,COG2303@2|Bacteria,1PEB3@1224|Proteobacteria,42WR0@68525|delta/epsilon subdivisions,2WS23@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
SRD2_k127_7484023_11	1380356.JNIK01000014_gene3478	1.415e-08	57.0	COG2197@1|root,COG2197@2|Bacteria,2INZX@201174|Actinobacteria,4EW4I@85013|Frankiales	201174|Actinobacteria	T	PFAM response regulator receiver	-	-	-	ko:K07689	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
SRD2_k127_7484023_5	298655.KI912266_gene991	5.095e-75	258.0	COG2197@1|root,COG2197@2|Bacteria,2IIDD@201174|Actinobacteria	201174|Actinobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
SRD2_k127_7484023_2	298655.KI912267_gene7142	2.352e-158	514.0	COG2114@1|root,COG2197@1|root,COG2114@2|Bacteria,COG2197@2|Bacteria,2GJRI@201174|Actinobacteria	201174|Actinobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,Response_reg
SRD2_k127_7484023_4	1298863.AUEP01000001_gene785	1.908e-79	293.0	COG4585@1|root,COG4585@2|Bacteria,2GMMU@201174|Actinobacteria,4DV3H@85009|Propionibacteriales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
SRD2_k127_7484023_10	926554.KI912671_gene265	2.615e-09	70.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	CCP_MauG,Copper-bind,Cu-oxidase_3,Cupredoxin_1
SRD2_k127_7484023_0	1449976.KALB_3698	8.102e-223	709.0	COG1132@1|root,COG1132@2|Bacteria,2GJYK@201174|Actinobacteria,4DZ3N@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SRD2_k127_7484023_3	497964.CfE428DRAFT_0631	5.294e-152	514.0	COG2114@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3903@2|Bacteria,46TZ3@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,NB-ARC
SRD2_k127_7484023_1	1382306.JNIM01000001_gene2361	3.496e-179	591.0	COG1472@1|root,COG1472@2|Bacteria,2G639@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the glycosyl hydrolase 3 family	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
SRD2_k127_7484023_7	1123073.KB899242_gene918	7.45e-55	202.0	COG5587@1|root,COG5587@2|Bacteria,1R8B4@1224|Proteobacteria,1S1WW@1236|Gammaproteobacteria,1XD2G@135614|Xanthomonadales	135614|Xanthomonadales	S	Conserved hypothetical protein (DUF2461)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2461
SRD2_k127_7484023_9	326424.FRAAL0744	2.801e-11	65.0	COG1403@1|root,COG1403@2|Bacteria,2GU7G@201174|Actinobacteria	201174|Actinobacteria	V	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
SRD2_k127_7494361_3	1353528.DT23_18630	0.0008789	47.0	COG0827@1|root,COG0827@2|Bacteria,1PZHE@1224|Proteobacteria,2V8I0@28211|Alphaproteobacteria,2XPB8@285107|Thioclava	28211|Alphaproteobacteria	K	DNA restriction-modification system	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_7494361_1	195105.CN97_03990	1.221e-21	97.0	COG2963@1|root,COG2963@2|Bacteria,1N2T5@1224|Proteobacteria,2U9CF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2963 Transposase and inactivated derivatives	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
SRD2_k127_7494361_0	1123242.JH636434_gene4478	7.639e-97	330.0	COG2801@1|root,COG2801@2|Bacteria,2IZD7@203682|Planctomycetes	203682|Planctomycetes	L	Best DB hits BLAST gb AAA88919.1	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve
SRD2_k127_7494361_2	886293.Sinac_1231	8.345e-18	95.0	COG3464@1|root,COG3464@2|Bacteria,2J4EX@203682|Planctomycetes	203682|Planctomycetes	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_749885_7	530564.Psta_4501	8.774e-65	241.0	COG1454@1|root,COG1454@2|Bacteria,2IXD7@203682|Planctomycetes	203682|Planctomycetes	C	Iron-containing alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001,ko:K13954	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
SRD2_k127_749885_3	1111479.AXAR01000005_gene458	1.285e-93	329.0	COG1063@1|root,COG1063@2|Bacteria,1TPIW@1239|Firmicutes,4HB2G@91061|Bacilli,278YF@186823|Alicyclobacillaceae	91061|Bacilli	E	Alcohol dehydrogenase GroES-associated	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
SRD2_k127_749885_9	1382304.JNIL01000001_gene1586	2.39e-47	192.0	COG0237@1|root,COG0237@2|Bacteria,1V6FS@1239|Firmicutes,4HII3@91061|Bacilli,279RN@186823|Alicyclobacillaceae	91061|Bacilli	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS08510	CoaE
SRD2_k127_749885_13	555088.DealDRAFT_0891	2.279e-36	158.0	COG0842@1|root,COG0842@2|Bacteria,1TQG7@1239|Firmicutes,249TT@186801|Clostridia,42KBN@68298|Syntrophomonadaceae	186801|Clostridia	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
SRD2_k127_749885_5	700598.Niako_2090	2.567e-90	306.0	COG1131@1|root,COG1131@2|Bacteria,4NMN9@976|Bacteroidetes	976|Bacteroidetes	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SRD2_k127_749885_17	1032480.MLP_44000	6.183e-30	133.0	COG3877@1|root,COG3877@2|Bacteria,2IT3M@201174|Actinobacteria,4DVDP@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF2089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2089
SRD2_k127_749885_18	1120950.KB892763_gene5545	2.09e-21	104.0	2B5R0@1|root,31YKI@2|Bacteria,2IPMA@201174|Actinobacteria,4DR93@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_749885_4	290397.Adeh_2342	1.298e-92	319.0	COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,42PNZ@68525|delta/epsilon subdivisions,2WM13@28221|Deltaproteobacteria,2YUDU@29|Myxococcales	28221|Deltaproteobacteria	C	CoA-transferase family III	-	-	5.1.99.4	ko:K01796	ko00120,ko01100,ko04146,map00120,map01100,map04146	M00104	R08734,R08739	RC02345	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
SRD2_k127_749885_8	1380390.JIAT01000010_gene4906	1.034e-48	188.0	COG0491@1|root,COG0491@2|Bacteria,2HGYI@201174|Actinobacteria,4CQY2@84995|Rubrobacteria	84995|Rubrobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SRD2_k127_749885_14	1128421.JAGA01000003_gene3579	8.523e-36	140.0	COG1832@1|root,COG1832@2|Bacteria,2NRIH@2323|unclassified Bacteria	2|Bacteria	S	CoA binding domain	yccU	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
SRD2_k127_749885_1	1463841.JOIR01000015_gene6532	8.409e-154	507.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,2GMFH@201174|Actinobacteria	201174|Actinobacteria	E	PHP domain	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_thumb,HHH_5,HHH_8,PHP
SRD2_k127_749885_6	1121091.AUMP01000022_gene3779	2.713e-80	277.0	COG1210@1|root,COG1210@2|Bacteria,1TQ24@1239|Firmicutes,4HATY@91061|Bacilli	91061|Bacilli	M	UTP-glucose-1-phosphate uridylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transferase
SRD2_k127_749885_15	1894.JOER01000058_gene3222	9.232e-35	151.0	COG4990@1|root,COG4990@2|Bacteria,2H66Y@201174|Actinobacteria	201174|Actinobacteria	S	Peptidase_C39 like family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C39_2
SRD2_k127_749885_16	926550.CLDAP_37940	2.41e-30	126.0	COG1595@1|root,COG1595@2|Bacteria,2G6X7@200795|Chloroflexi	200795|Chloroflexi	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SRD2_k127_749885_0	1385510.N781_11815	1.757e-156	503.0	COG0156@1|root,COG0156@2|Bacteria,1TPUX@1239|Firmicutes,4HAH3@91061|Bacilli,2Y8UA@289201|Pontibacillus	91061|Bacilli	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	kbl	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
SRD2_k127_749885_2	1128421.JAGA01000002_gene163	8.805e-104	349.0	COG1063@1|root,COG1063@2|Bacteria,2NPK3@2323|unclassified Bacteria	2|Bacteria	E	Zinc-binding dehydrogenase	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
SRD2_k127_749885_20	1120936.KB907227_gene2935	1.105e-15	79.0	COG1522@1|root,COG1522@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
SRD2_k127_749885_11	234267.Acid_5474	4.215e-38	148.0	COG4276@1|root,COG4276@2|Bacteria,3Y57N@57723|Acidobacteria	57723|Acidobacteria	S	Pfam Polyketide cyclase dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
SRD2_k127_749885_12	929712.KI912613_gene1421	5.001e-37	154.0	COG3268@1|root,COG3268@2|Bacteria,2GMKU@201174|Actinobacteria,4CSJP@84995|Rubrobacteria	84995|Rubrobacteria	S	Saccharopine dehydrogenase NADP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_NADP
SRD2_k127_749885_19	740709.A10D4_11059	6.731e-16	84.0	COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,1RMW7@1236|Gammaproteobacteria,2QF2M@267893|Idiomarinaceae	1236|Gammaproteobacteria	K	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	cpxR	GO:0003674,GO:0003700,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010810,GO:0019219,GO:0019222,GO:0030155,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141	-	ko:K07662,ko:K19610	ko01503,ko02020,map01503,map02020	M00447,M00727,M00728,M00770	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SRD2_k127_749885_10	1128421.JAGA01000001_gene2354	9.337e-45	175.0	COG0642@1|root,COG2205@2|Bacteria	1128421.JAGA01000001_gene2354|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_7531081_0	1223542.GM1_057_00030	5.395e-07	62.0	KOG2232@1|root,2Z84X@2|Bacteria,2GS3B@201174|Actinobacteria,4GAUR@85026|Gordoniaceae	201174|Actinobacteria	S	Neutral/alkaline non-lysosomal ceramidase, C-terminal	-	-	3.5.1.23	ko:K12349	ko00600,ko01100,ko04071,map00600,map01100,map04071	M00099	R01494	RC00064,RC00328	ko00000,ko00001,ko00002,ko01000	-	-	-	Ceramidase_alk,Ceramidse_alk_C
SRD2_k127_7576789_4	1123313.ATUT01000002_gene379	1.145e-19	96.0	COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,3VPC9@526524|Erysipelotrichia	526524|Erysipelotrichia	E	ABC transporter, substrate-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
SRD2_k127_7576789_0	1051632.TPY_0985	1.534e-132	438.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,3WCUJ@538999|Clostridiales incertae sedis	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
SRD2_k127_7576789_1	292459.STH2824	1.352e-119	395.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
SRD2_k127_7576789_2	511051.CSE_11690	1.367e-71	259.0	COG1173@1|root,COG1173@2|Bacteria	2|Bacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	appC	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
SRD2_k127_7576789_3	1211817.CCAT010000045_gene2930	4.922e-70	248.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,36F10@31979|Clostridiaceae	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
SRD2_k127_758989_0	1089545.KB913037_gene7052	7.399e-221	691.0	COG0296@1|root,COG0296@2|Bacteria,2GJ5C@201174|Actinobacteria,4E0S6@85010|Pseudonocardiales	201174|Actinobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
SRD2_k127_758989_13	637905.SVI_1062	1.127e-42	166.0	COG3221@1|root,COG3221@2|Bacteria,1PFPM@1224|Proteobacteria,1SXBG@1236|Gammaproteobacteria,2QDCZ@267890|Shewanellaceae	1236|Gammaproteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
SRD2_k127_758989_11	1078020.KEK_09897	6.274e-52	186.0	COG0432@1|root,COG0432@2|Bacteria,2IHWS@201174|Actinobacteria,2398U@1762|Mycobacteriaceae	201174|Actinobacteria	S	Uncharacterised protein family UPF0047	-	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	UPF0047
SRD2_k127_758989_1	986075.CathTA2_2387	6.544e-192	617.0	COG0441@1|root,COG0441@2|Bacteria,1TP78@1239|Firmicutes,4HABZ@91061|Bacilli	91061|Bacilli	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
SRD2_k127_758989_6	1169161.KB897729_gene1305	7.298e-110	369.0	COG2309@1|root,COG2309@2|Bacteria,2ID23@201174|Actinobacteria	201174|Actinobacteria	E	PFAM peptidase M29, aminopeptidase II	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
SRD2_k127_758989_12	485915.Dret_0044	2.169e-51	190.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,42RHA@68525|delta/epsilon subdivisions,2WNQW@28221|Deltaproteobacteria,2M933@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
SRD2_k127_758989_20	1034345.CAEM01000023_gene846	1.761e-11	68.0	COG0291@1|root,COG0291@2|Bacteria,2HV94@201174|Actinobacteria,4CWHW@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
SRD2_k127_758989_14	637389.Acaty_c2401	2.379e-41	156.0	COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,1S3P3@1236|Gammaproteobacteria,2NCYB@225057|Acidithiobacillales	225057|Acidithiobacillales	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
SRD2_k127_758989_7	1278073.MYSTI_04357	1.186e-106	356.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,42MB0@68525|delta/epsilon subdivisions,2WJ42@28221|Deltaproteobacteria,2YWE0@29|Myxococcales	28221|Deltaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF987.Gmet_1415	Phe_tRNA-synt_N,tRNA-synt_2d
SRD2_k127_758989_2	1125863.JAFN01000001_gene1869	2.816e-154	515.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,42M1G@68525|delta/epsilon subdivisions,2WJ7V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Phenylalanyl-tRNA synthetase, beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
SRD2_k127_758989_15	370438.PTH_1946	2.274e-39	157.0	COG2094@1|root,COG2094@2|Bacteria,1V1E6@1239|Firmicutes,24FRV@186801|Clostridia,261K2@186807|Peptococcaceae	186801|Clostridia	L	Belongs to the DNA glycosylase MPG family	-	-	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
SRD2_k127_758989_5	246194.CHY_1563	3.641e-110	383.0	COG0744@1|root,COG0744@2|Bacteria,1TPM5@1239|Firmicutes,248A4@186801|Clostridia,42EPS@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM glycosyl transferase, family 51	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
SRD2_k127_758989_3	765912.Thimo_1034	7.949e-124	408.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,1RPKC@1236|Gammaproteobacteria,1WX6G@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
SRD2_k127_758989_10	118005.AWNK01000007_gene586	5.073e-78	268.0	COG0217@1|root,COG0217@2|Bacteria	2|Bacteria	K	transcriptional regulatory protein	yebC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
SRD2_k127_758989_21	2002.JOEQ01000026_gene393	0.0001208	53.0	COG0342@1|root,COG3266@1|root,COG0342@2|Bacteria,COG3266@2|Bacteria,2GJTT@201174|Actinobacteria,4EFFG@85012|Streptosporangiales	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
SRD2_k127_758989_16	292459.STH1159	9.615e-39	155.0	COG0817@1|root,COG0817@2|Bacteria,1V3N9@1239|Firmicutes,24HMI@186801|Clostridia	186801|Clostridia	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
SRD2_k127_758989_17	243231.GSU1076	2.217e-35	149.0	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,42RPS@68525|delta/epsilon subdivisions,2WPH5@28221|Deltaproteobacteria,43U6G@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
SRD2_k127_758989_18	240015.ACP_2023	3.091e-27	120.0	COG5424@1|root,COG5424@2|Bacteria,3Y718@57723|Acidobacteria,2JKMM@204432|Acidobacteriia	204432|Acidobacteriia	H	Iron-containing redox enzyme	-	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	Haem_oxygenas_2
SRD2_k127_758989_4	370438.PTH_1027	8.596e-122	401.0	COG2255@1|root,COG2255@2|Bacteria,1TR47@1239|Firmicutes,247W0@186801|Clostridia,260GK@186807|Peptococcaceae	186801|Clostridia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
SRD2_k127_758989_8	1111454.HMPREF1250_1185	4.097e-103	346.0	COG0809@1|root,COG0809@2|Bacteria,1TPKD@1239|Firmicutes,4H1WD@909932|Negativicutes	909932|Negativicutes	H	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
SRD2_k127_758989_9	1121448.DGI_1636	1.006e-93	326.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,42M5Y@68525|delta/epsilon subdivisions,2WIMT@28221|Deltaproteobacteria,2M9GZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
SRD2_k127_758989_19	1123322.KB904636_gene2806	1.798e-15	84.0	COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,2GJTT@201174|Actinobacteria	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
SRD2_k127_7640359_10	1343739.PAP_01545	1.999e-47	177.0	COG0537@1|root,arCOG00419@2157|Archaea,2XWGT@28890|Euryarchaeota,242M1@183968|Thermococci	183968|Thermococci	F	Hit family	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
SRD2_k127_7640359_4	1500897.JQNA01000002_gene4645	8.02e-109	387.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1K0RA@119060|Burkholderiaceae	28216|Betaproteobacteria	T	GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GAF_2,GGDEF,HAMP,PAS,PAS_4,PAS_8,PAS_9,dCache_3
SRD2_k127_7640359_0	1382356.JQMP01000004_gene261	0.0	1015.0	COG0495@1|root,COG0495@2|Bacteria,2G5MX@200795|Chloroflexi,27XYD@189775|Thermomicrobia	189775|Thermomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
SRD2_k127_7640359_7	1463920.JOGB01000053_gene5026	9.611e-84	289.0	COG0596@1|root,COG0596@2|Bacteria,2I1Q9@201174|Actinobacteria	201174|Actinobacteria	EGP	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
SRD2_k127_7640359_13	1120944.JONS01000003_gene1631	2.599e-21	101.0	COG1555@1|root,COG1555@2|Bacteria,2IQDC@201174|Actinobacteria,4D3V2@85005|Actinomycetales	201174|Actinobacteria	L	ComEA protein	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
SRD2_k127_7640359_14	208439.AJAP_29440	3.536e-18	100.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,2GJGR@201174|Actinobacteria,4DXGV@85010|Pseudonocardiales	201174|Actinobacteria	S	DNA internalization-related competence protein ComEC Rec2	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
SRD2_k127_7640359_15	1125863.JAFN01000001_gene1807	4.742e-18	95.0	COG1466@1|root,COG1466@2|Bacteria,1RHE9@1224|Proteobacteria,42SNR@68525|delta/epsilon subdivisions,2WP96@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DNA polymerase III, delta' subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
SRD2_k127_7640359_16	525904.Tter_0947	4.748e-12	73.0	COG0268@1|root,COG0268@2|Bacteria,2NQ42@2323|unclassified Bacteria	2|Bacteria	J	Binds directly to 16S ribosomal RNA	rpsT	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
SRD2_k127_7640359_9	926550.CLDAP_01110	1.328e-62	239.0	COG0728@1|root,COG0728@2|Bacteria,2G5MD@200795|Chloroflexi	200795|Chloroflexi	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
SRD2_k127_7640359_12	1122223.KB890697_gene1063	2.862e-37	152.0	COG1947@1|root,COG1947@2|Bacteria,1WJXM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
SRD2_k127_7640359_2	1128421.JAGA01000003_gene3528	3.972e-117	394.0	COG0771@1|root,COG0771@2|Bacteria	2|Bacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	3.4.21.10,6.3.2.13,6.3.2.9	ko:K01317,ko:K01925,ko:K01928,ko:K01932	ko00300,ko00471,ko00550,ko01100,map00300,map00471,map00550,map01100	-	R02783,R02788	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01002,ko01011,ko04131	-	-	-	DUF1727,Mur_ligase_C,Mur_ligase_M
SRD2_k127_7640359_8	645991.Sgly_2696	3.963e-65	232.0	COG3442@1|root,COG3442@2|Bacteria,1U7I9@1239|Firmicutes,24A80@186801|Clostridia,260S1@186807|Peptococcaceae	186801|Clostridia	H	PFAM CobB CobQ-like glutamine amidotransferase	-	-	-	ko:K07009	-	-	-	-	ko00000	-	-	-	GATase_3
SRD2_k127_7640359_3	696369.KI912183_gene2313	3.202e-112	378.0	COG1207@1|root,COG1207@2|Bacteria,1TP88@1239|Firmicutes,248Z3@186801|Clostridia,2609P@186807|Peptococcaceae	186801|Clostridia	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase
SRD2_k127_7640359_5	246194.CHY_0193	1.421e-104	349.0	COG0462@1|root,COG0462@2|Bacteria,1TQ6Q@1239|Firmicutes,248ZN@186801|Clostridia,42EXR@68295|Thermoanaerobacterales	186801|Clostridia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
SRD2_k127_7640359_6	1382306.JNIM01000001_gene2574	9.742e-94	325.0	COG1253@1|root,COG1253@2|Bacteria,2G6D1@200795|Chloroflexi	200795|Chloroflexi	S	CBS domain containing protein	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
SRD2_k127_7640359_11	926569.ANT_08620	1.268e-37	151.0	COG1381@1|root,COG1381@2|Bacteria,2G6N7@200795|Chloroflexi	200795|Chloroflexi	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
SRD2_k127_7640359_1	1499967.BAYZ01000184_gene4573	3.136e-170	547.0	COG0423@1|root,COG0423@2|Bacteria,2NNN9@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009345,GO:0009987,GO:0010467,GO:0016070,GO:0016594,GO:0016597,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0042165,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046983,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iSB619.SA_RS07880	HGTP_anticodon,tRNA-synt_2b
SRD2_k127_7653896_1	926569.ANT_18400	2.677e-06	61.0	COG1287@1|root,COG1287@2|Bacteria,2G785@200795|Chloroflexi	200795|Chloroflexi	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_7653896_0	404380.Gbem_1051	3.075e-50	197.0	COG1287@1|root,COG1287@2|Bacteria,1N1IK@1224|Proteobacteria,42RRN@68525|delta/epsilon subdivisions,2WNAY@28221|Deltaproteobacteria,43SI2@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_7670250_1	935845.JADQ01000048_gene2432	3.923e-64	228.0	COG1694@1|root,COG3956@2|Bacteria,1TPK1@1239|Firmicutes,4HA0A@91061|Bacilli,26QBT@186822|Paenibacillaceae	91061|Bacilli	S	Protein containing tetrapyrrole methyltransferase domain and MazG-like	yabN	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG,TP_methylase
SRD2_k127_7670250_0	243164.DET1281	2.079e-204	654.0	COG1197@1|root,COG1197@2|Bacteria,2G5UW@200795|Chloroflexi,34CKB@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
SRD2_k127_770069_4	246197.MXAN_2411	4.287e-33	135.0	COG1249@1|root,COG1249@2|Bacteria,1MVVE@1224|Proteobacteria,42Z7G@68525|delta/epsilon subdivisions,2WU0D@28221|Deltaproteobacteria,2YU48@29|Myxococcales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	sthA	-	1.6.1.1	ko:K00322	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
SRD2_k127_770069_8	1123302.KB904178_gene139	3.489e-05	57.0	COG3525@1|root,COG4409@1|root,COG4932@1|root,COG3525@2|Bacteria,COG4409@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	nanA	GO:0001573,GO:0003674,GO:0003824,GO:0004308,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006672,GO:0006687,GO:0006689,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0016020,GO:0016042,GO:0016052,GO:0016787,GO:0016798,GO:0016997,GO:0019377,GO:0030149,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044424,GO:0044464,GO:0046466,GO:0046479,GO:0046514,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1903509	2.7.13.3,3.2.1.18,3.2.1.52	ko:K01186,ko:K02476,ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00600,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00600,map00603,map00604,map01100,map04142	M00079	R00022,R04018,R06004,R11316	RC00028,RC00049,RC00077	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02042,ko03110	-	GH20,GH33	-	BNR_2,F5_F8_type_C,FIVAR,Glyco_hydro_20,Glyco_hydro_20b,Gram_pos_anchor,Laminin_G_3,NAGidase,Sialidase,YSIRK_signal
SRD2_k127_770069_5	331678.Cphamn1_1038	1.047e-19	104.0	COG1664@1|root,COG1664@2|Bacteria,1FF2Q@1090|Chlorobi	1090|Chlorobi	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_770069_1	525904.Tter_0396	4.307e-100	334.0	COG2141@1|root,COG2141@2|Bacteria,2NQM2@2323|unclassified Bacteria	2|Bacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
SRD2_k127_770069_2	106370.Francci3_2905	1.442e-96	327.0	COG0667@1|root,COG0667@2|Bacteria,2GJ4R@201174|Actinobacteria,4EU63@85013|Frankiales	201174|Actinobacteria	C	aldo keto reductase	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SRD2_k127_770069_6	927677.ALVU02000001_gene712	2.234e-19	102.0	COG0671@1|root,COG0671@2|Bacteria,1G8C8@1117|Cyanobacteria,1H5Z9@1142|Synechocystis	1117|Cyanobacteria	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
SRD2_k127_770069_7	314266.SKA58_10600	2.734e-17	91.0	COG0671@1|root,COG0671@2|Bacteria,1RDK3@1224|Proteobacteria,2U7BJ@28211|Alphaproteobacteria,2K70Y@204457|Sphingomonadales	204457|Sphingomonadales	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
SRD2_k127_770069_0	68199.JNZO01000001_gene1148	1.596e-152	492.0	COG2015@1|root,COG2015@2|Bacteria,2H3T3@201174|Actinobacteria	201174|Actinobacteria	Q	Alkyl sulfatase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_dimr,Lactamase_B
SRD2_k127_770069_3	1382306.JNIM01000001_gene2361	1.451e-72	258.0	COG1472@1|root,COG1472@2|Bacteria,2G639@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the glycosyl hydrolase 3 family	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
SRD2_k127_7717729_0	326424.FRAAL0441	5.004e-64	228.0	COG0428@1|root,COG0428@2|Bacteria,2IBHZ@201174|Actinobacteria,4ESCI@85013|Frankiales	201174|Actinobacteria	P	ZIP Zinc transporter	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
SRD2_k127_7771794_1	525904.Tter_0079	3.293e-62	228.0	COG0342@1|root,COG0342@2|Bacteria,2NNNU@2323|unclassified Bacteria	2|Bacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	6.3.2.2	ko:K01919,ko:K03072,ko:K12257	ko00270,ko00480,ko01100,ko02024,ko03060,ko03070,map00270,map00480,map01100,map02024,map03060,map03070	M00118,M00335	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	GshA,SecD_SecF,Sec_GG
SRD2_k127_7771794_2	309801.trd_0649	1.009e-56	209.0	COG0341@1|root,COG0341@2|Bacteria,2G696@200795|Chloroflexi,27Y1D@189775|Thermomicrobia	189775|Thermomicrobia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
SRD2_k127_7771794_3	1123405.AUMM01000001_gene43	5.439e-16	84.0	COG0779@1|root,COG0779@2|Bacteria,1V6KT@1239|Firmicutes,4HH88@91061|Bacilli,26NUB@186821|Sporolactobacillaceae	91061|Bacilli	S	RimP C-terminal SH3 domain	rimP	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
SRD2_k127_7771794_0	525904.Tter_0912	1.165e-83	289.0	COG0195@1|root,COG0195@2|Bacteria,2NNV1@2323|unclassified Bacteria	2|Bacteria	K	Participates in both transcription termination and antitermination	nusA	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0040007,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
SRD2_k127_780021_0	316056.RPC_0244	2.733e-37	149.0	COG2335@1|root,COG2335@2|Bacteria,1RD06@1224|Proteobacteria,2U7H5@28211|Alphaproteobacteria,3JU54@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Four repeated domains in the Fasciclin I family of proteins, present in many other contexts.	MA20_43570	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
SRD2_k127_7863592_2	370438.PTH_1617	5.898e-35	139.0	COG0283@1|root,COG0283@2|Bacteria,1V3IA@1239|Firmicutes,24HEF@186801|Clostridia,261QH@186807|Peptococcaceae	186801|Clostridia	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
SRD2_k127_7863592_0	1121439.dsat_1538	1.036e-58	212.0	COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,42NI7@68525|delta/epsilon subdivisions,2WNPX@28221|Deltaproteobacteria,2M9YS@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.21,5.4.99.22	ko:K06178,ko:K06182	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
SRD2_k127_7863592_1	867845.KI911784_gene3740	2.843e-35	141.0	COG1386@1|root,COG1386@2|Bacteria,2G6V6@200795|Chloroflexi,375NU@32061|Chloroflexia	32061|Chloroflexia	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
SRD2_k127_7863592_3	264732.Moth_1361	4.854e-22	105.0	COG1354@1|root,COG1354@2|Bacteria,1TRW3@1239|Firmicutes,249VW@186801|Clostridia,42G4N@68295|Thermoanaerobacterales	186801|Clostridia	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
SRD2_k127_7863592_4	1392501.JIAC01000001_gene1263	3.319e-08	61.0	COG2206@1|root,COG2206@2|Bacteria,1VEWH@1239|Firmicutes,4H5GI@909932|Negativicutes	909932|Negativicutes	T	PFAM Metal-dependent phosphohydrolase, HD	-	-	-	-	-	-	-	-	-	-	-	-	HD
SRD2_k127_7879634_1	357808.RoseRS_0893	1.443e-57	211.0	COG3677@1|root,COG3677@2|Bacteria,2G6SJ@200795|Chloroflexi,3772U@32061|Chloroflexia	32061|Chloroflexia	L	PFAM Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_7879634_0	886293.Sinac_6050	4.882e-76	263.0	2DMFF@1|root,32R5F@2|Bacteria	2|Bacteria	S	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_822387_1	1068978.AMETH_4397	1.868e-52	188.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4DXK8@85010|Pseudonocardiales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
SRD2_k127_822387_3	1128421.JAGA01000002_gene963	4.484e-12	74.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	3.1.3.10	ko:K07025,ko:K20866	ko00010,ko01120,map00010,map01120	-	R00947	RC00078	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase
SRD2_k127_822387_0	1382306.JNIM01000001_gene1105	6.751e-131	440.0	COG2936@1|root,COG2936@2|Bacteria,2G85Q@200795|Chloroflexi	200795|Chloroflexi	S	PFAM X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	PepX_C,Peptidase_S15
SRD2_k127_822387_2	1117379.BABA_12101	2.684e-47	180.0	COG2267@1|root,COG2267@2|Bacteria,1UKWC@1239|Firmicutes,4ITKP@91061|Bacilli	91061|Bacilli	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
SRD2_k127_822387_4	287986.DV20_38975	1.655e-11	67.0	COG1174@1|root,COG1174@2|Bacteria,2GMU0@201174|Actinobacteria,4DYJM@85010|Pseudonocardiales	201174|Actinobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
SRD2_k127_91569_6	292459.STH2950	3.136e-50	194.0	COG2353@1|root,COG2353@2|Bacteria,1V1NX@1239|Firmicutes,24PTW@186801|Clostridia	186801|Clostridia	S	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
SRD2_k127_91569_2	1298880.AUEV01000002_gene1274	2.315e-114	377.0	COG1393@1|root,COG4977@1|root,COG1393@2|Bacteria,COG4977@2|Bacteria,2GIRA@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
SRD2_k127_91569_4	469383.Cwoe_4828	2.991e-84	302.0	28JQV@1|root,2Z9GM@2|Bacteria,2H335@201174|Actinobacteria,4CPRQ@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_91569_9	688269.Theth_0233	0.0008344	51.0	COG1933@1|root,COG1933@2|Bacteria,2GDRW@200918|Thermotogae	200918|Thermotogae	L	exodeoxyribonuclease I activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_91569_0	469383.Cwoe_4837	5.738e-201	638.0	COG2072@1|root,COG2072@2|Bacteria,2GJEA@201174|Actinobacteria,4CP9C@84995|Rubrobacteria	84995|Rubrobacteria	P	L-lysine 6-monooxygenase (NADPH-requiring)	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_3
SRD2_k127_91569_7	1463825.JNXC01000004_gene4287	3.095e-49	188.0	COG2267@1|root,COG2267@2|Bacteria,2GM96@201174|Actinobacteria,4E21G@85010|Pseudonocardiales	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
SRD2_k127_91569_5	1382306.JNIM01000001_gene1930	1.006e-61	222.0	COG1028@1|root,COG1028@2|Bacteria	1382306.JNIM01000001_gene1930|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_91569_1	1242864.D187_007188	8.656e-138	449.0	COG4214@1|root,COG4214@2|Bacteria,1MXXS@1224|Proteobacteria	1224|Proteobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10544	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4	-	-	BPD_transp_2
SRD2_k127_91569_3	479434.Sthe_3092	2.156e-88	298.0	COG1129@1|root,COG1129@2|Bacteria	2|Bacteria	G	ABC transporter	-	-	3.6.3.17	ko:K10544,ko:K10545	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.4	-	-	ABC_tran,BPD_transp_2
SRD2_k127_96949_1	525909.Afer_1523	3.093e-73	253.0	COG1290@1|root,COG1290@2|Bacteria,2GK58@201174|Actinobacteria,4CNNI@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_96949_4	235985.BBPN01000009_gene3761	5.98e-05	46.0	COG1290@1|root,COG1290@2|Bacteria,2GTS3@201174|Actinobacteria,2NK48@228398|Streptacidiphilus	201174|Actinobacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_96949_3	58123.JOFJ01000028_gene2818	1.225e-25	113.0	2A18G@1|root,30PEU@2|Bacteria,2IGED@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRD2_k127_96949_0	1382356.JQMP01000003_gene1584	4.983e-265	844.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2G5QB@200795|Chloroflexi,27XKK@189775|Thermomicrobia	189775|Thermomicrobia	C	Succinyl-CoA ligase like flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
SRD2_k127_96949_2	105422.BBPM01000051_gene1495	5.314e-55	197.0	COG2197@1|root,COG2197@2|Bacteria,2GK4B@201174|Actinobacteria,2NF0X@228398|Streptacidiphilus	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
## 2465 queries scanned
## Total time (seconds): 177.81599473953247
## Rate: 13.86 q/s