## Fri Oct 18 17:09:03 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/Potential_rubisco_autotrophic/SX1_bin.11.fa -m mmseqs --itype genome -o SX1_bin.11 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/all_bins_1385/SX1_bin.11 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
SX1_k127_1013258_3	1035839.AFNK01000079_gene32	5.823e-06	58.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,1RNES@1236|Gammaproteobacteria,1Y74W@135625|Pasteurellales	135625|Pasteurellales	E	Periplasmic dipeptide transport protein of	dppA	-	-	ko:K12368	ko02010,ko02030,map02010,map02030	M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
SX1_k127_1013258_1	1231057.AMGD01000004_gene2898	2.521e-51	192.0	COG2159@1|root,COG2159@2|Bacteria,1TT5D@1239|Firmicutes,4HAHP@91061|Bacilli	91061|Bacilli	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
SX1_k127_1013258_2	1231057.AMGD01000004_gene2899	2.642e-48	183.0	COG0363@1|root,COG0363@2|Bacteria,1TQK7@1239|Firmicutes	1239|Firmicutes	G	Psort location Cytoplasmic, score 8.87	-	-	3.5.99.6	ko:K02564	ko00520,ko01100,map00520,map01100	-	R00765	RC00163	ko00000,ko00001,ko01000	-	-	-	-
SX1_k127_1013258_0	1382359.JIAL01000001_gene469	2.19e-58	206.0	COG0225@1|root,COG0225@2|Bacteria,3Y4DM@57723|Acidobacteria,2JJ10@204432|Acidobacteriia	204432|Acidobacteriia	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	-	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
SX1_k127_1014892_4	278957.ABEA03000135_gene1751	9.861e-20	91.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	PD40
SX1_k127_1014892_5	909663.KI867150_gene1316	4.793e-12	77.0	COG0697@1|root,COG0697@2|Bacteria,1MWSU@1224|Proteobacteria,42QP3@68525|delta/epsilon subdivisions,2WMTD@28221|Deltaproteobacteria,2MQP7@213462|Syntrophobacterales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SX1_k127_1014892_0	1089548.KI783301_gene3173	1.081e-133	439.0	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,4H9YT@91061|Bacilli,3WE0W@539002|Bacillales incertae sedis	91061|Bacilli	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
SX1_k127_1014892_1	1150474.JQJI01000057_gene963	2.496e-119	417.0	COG0383@1|root,COG0383@2|Bacteria,2GCGE@200918|Thermotogae	200918|Thermotogae	G	PFAM glycoside hydrolase family 38	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
SX1_k127_1014892_3	293826.Amet_1439	2.127e-39	157.0	COG0508@1|root,COG0508@2|Bacteria	2|Bacteria	C	S-acyltransferase activity	-	-	2.3.1.12,2.7.11.1,3.6.4.13	ko:K00627,ko:K03310,ko:K03578,ko:K12132	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000,ko01001	2.A.25	-	-	2-oxoacid_dh,Biotin_lipoyl
SX1_k127_1014892_2	1519464.HY22_06050	3.836e-46	179.0	COG1215@1|root,COG1215@2|Bacteria,1FDR6@1090|Chlorobi	1090|Chlorobi	M	PFAM glycosyl transferase family 2	-	-	-	ko:K14597	ko00906,map00906	-	R07544,R07546	RC00262	ko00000,ko00001	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
SX1_k127_1016293_0	5741.EDO78070	5.507e-63	220.0	COG1042@1|root,2QWQW@2759|Eukaryota	2759|Eukaryota	C	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
SX1_k127_1016293_1	1121472.AQWN01000002_gene2324	2.534e-52	198.0	COG0857@1|root,COG0857@2|Bacteria,1UFKM@1239|Firmicutes,25M79@186801|Clostridia,260XJ@186807|Peptococcaceae	186801|Clostridia	C	DRTGG domain protein	-	-	-	ko:K06873	-	-	-	-	ko00000	-	-	-	AAA_26,DRTGG
SX1_k127_1016293_4	665571.STHERM_c10710	1.371e-34	138.0	COG0537@1|root,COG0537@2|Bacteria,2JAFV@203691|Spirochaetes	203691|Spirochaetes	FG	HIT domain	-	-	-	-	-	-	-	-	-	-	-	-	HIT
SX1_k127_1016293_5	1056495.Calag_1456	1.73e-17	87.0	COG1931@1|root,arCOG01043@2157|Archaea,2XQU6@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the UPF0201 family	-	-	-	ko:K09736	-	-	-	-	ko00000	-	-	-	RNA_binding
SX1_k127_1016293_3	224325.AF_1395	5.318e-40	154.0	COG0237@1|root,arCOG01045@2157|Archaea,2XWNJ@28890|Euryarchaeota,245NW@183980|Archaeoglobi	183980|Archaeoglobi	H	Belongs to the UPF0200 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_17,RNA_binding
SX1_k127_1016293_2	1056495.Calag_0953	8.903e-45	168.0	COG1085@1|root,arCOG00422@2157|Archaea,2XPRT@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM galactose-1-phosphate uridyl transferase domain protein	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
SX1_k127_1024633_2	485914.Hmuk_0207	1.508e-20	93.0	COG3839@1|root,arCOG00175@2157|Archaea,2Y7MN@28890|Euryarchaeota,240VM@183963|Halobacteria	183963|Halobacteria	E	COG3839 ABC-type sugar transport systems, ATPase components	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
SX1_k127_1024633_0	1054217.TALC_00236	2.035e-77	281.0	COG1178@1|root,arCOG00163@2157|Archaea	2157|Archaea	P	ABC-type Fe3 transport system permease component	-	-	-	ko:K02053,ko:K02054,ko:K02063	ko02010,ko02024,map02010,map02024	M00191,M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11,3.A.1.19	-	-	BPD_transp_1
SX1_k127_1024633_1	357808.RoseRS_2799	1.647e-51	198.0	COG1840@1|root,COG2304@1|root,COG1840@2|Bacteria,COG2304@2|Bacteria,2G7PB@200795|Chloroflexi,376FM@32061|Chloroflexia	32061|Chloroflexia	P	PFAM von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	SBP_bac_11,VWA
SX1_k127_1035058_1	591019.Shell_0985	0.0006263	50.0	COG2404@1|root,arCOG00423@2157|Archaea,2XQ5M@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM DHHA1 domain	-	-	-	ko:K07097	-	-	-	-	ko00000	-	-	-	DHHA1
SX1_k127_1035058_0	1365176.N186_03845	2.201e-41	168.0	arCOG00986@1|root,arCOG00986@2157|Archaea,2XSNF@28889|Crenarchaeota	28889|Crenarchaeota	J	FtsJ-like methyltransferase	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,PUA
SX1_k127_1036774_0	32049.SYNPCC7002_A0393	1.205e-17	92.0	COG0747@1|root,COG0747@2|Bacteria,1G1K6@1117|Cyanobacteria,1GYBV@1129|Synechococcus	1117|Cyanobacteria	E	ABC-type dipeptide transport system, periplasmic component	ddpA	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
SX1_k127_1039175_0	224325.AF_1297	1.718e-213	681.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,245UG@183980|Archaeoglobi	183980|Archaeoglobi	O	AAA family ATPase, CDC48 subfamily	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
SX1_k127_1039175_3	573064.Mefer_1539	3.283e-23	111.0	COG4088@1|root,arCOG01041@2157|Archaea,2XWNQ@28890|Euryarchaeota,23QTG@183939|Methanococci	183939|Methanococci	F	PFAM Chromatin associated protein KTI12	pstK	-	2.7.1.164	ko:K10837	ko00450,ko00970,map00450,map00970	-	R08223	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	KTI12
SX1_k127_1039175_4	1354300.AUQY01000002_gene875	1.1e-16	82.0	COG2827@1|root,COG2827@2|Bacteria,1VEZF@1239|Firmicutes,24QYU@186801|Clostridia	186801|Clostridia	L	GIY-YIG catalytic domain	-	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
SX1_k127_1039175_2	1365176.N186_01510	1.07e-41	164.0	COG0084@1|root,arCOG00891@2157|Archaea,2XQSK@28889|Crenarchaeota	28889|Crenarchaeota	L	TatD related DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
SX1_k127_1039175_1	673860.AciM339_1421	5.89e-90	320.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,3F2ID@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	helicase superfamily c-terminal domain	hef	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,HHH_5,Helicase_C,ResIII
SX1_k127_1039175_5	1177154.Y5S_00562	2.884e-08	64.0	COG2020@1|root,COG2020@2|Bacteria,1MUBZ@1224|Proteobacteria,1RREG@1236|Gammaproteobacteria,1XJ9N@135619|Oceanospirillales	135619|Oceanospirillales	O	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
SX1_k127_1053011_0	926569.ANT_15720	5.453e-118	393.0	COG0535@1|root,COG0535@2|Bacteria,2G5XT@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Radical SAM domain protein	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
SX1_k127_1053011_1	1041930.Mtc_0044	6.592e-45	180.0	COG0535@1|root,arCOG00941@2157|Archaea,2Y8D6@28890|Euryarchaeota,2NBHW@224756|Methanomicrobia	224756|Methanomicrobia	S	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
SX1_k127_105496_5	42068.L0PE58	1.675e-10	64.0	COG0099@1|root,KOG3311@2759|Eukaryota,39ZZ4@33154|Opisthokonta,3P2B2@4751|Fungi,3QMMZ@4890|Ascomycota,3MCG7@451866|Taphrinomycotina	4751|Fungi	J	40S ribosomal protein S18	RPS18	GO:0000447,GO:0000460,GO:0000462,GO:0000466,GO:0000469,GO:0000478,GO:0000479,GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006403,GO:0006405,GO:0006407,GO:0006412,GO:0006518,GO:0006611,GO:0006725,GO:0006807,GO:0006810,GO:0006886,GO:0006913,GO:0008104,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015031,GO:0015833,GO:0015931,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0031503,GO:0032991,GO:0033036,GO:0034470,GO:0034613,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0042886,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045184,GO:0046483,GO:0046907,GO:0050657,GO:0050658,GO:0051029,GO:0051168,GO:0051169,GO:0051179,GO:0051234,GO:0051236,GO:0051641,GO:0051649,GO:0070727,GO:0071166,GO:0071426,GO:0071428,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097064,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02964	ko03010,map03010	M00177	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
SX1_k127_105496_0	1121289.JHVL01000009_gene1461	1.04e-44	178.0	COG0624@1|root,COG0624@2|Bacteria,1TPMJ@1239|Firmicutes,24BEY@186801|Clostridia,36J2T@31979|Clostridiaceae	186801|Clostridia	E	TIGRFAM acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase	-	-	3.5.1.16,3.5.1.18	ko:K01438,ko:K01439	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00669,R02734,R09107	RC00064,RC00090,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
SX1_k127_105496_1	588581.Cpap_2867	1.492e-23	104.0	COG1694@1|root,COG1694@2|Bacteria,1VA3E@1239|Firmicutes,24NYY@186801|Clostridia	186801|Clostridia	S	MazG nucleotide pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	MazG-like
SX1_k127_105496_3	264730.PSPPH_1434	2.402e-19	98.0	COG0596@1|root,COG0596@2|Bacteria,1RDP1@1224|Proteobacteria,1S67D@1236|Gammaproteobacteria,1Z70V@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	S	Serine aminopeptidase, S33	-	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
SX1_k127_105496_2	579137.Metvu_0277	2.846e-22	109.0	COG0142@1|root,arCOG01726@2157|Archaea,2XTAC@28890|Euryarchaeota,23QRB@183939|Methanococci	183939|Methanococci	H	Belongs to the FPP GGPP synthase family	idsA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
SX1_k127_105496_4	537013.CLOSTMETH_00060	1.063e-11	74.0	2F5DW@1|root,33XZS@2|Bacteria,1UT5H@1239|Firmicutes,251FX@186801|Clostridia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_1067115_5	693661.Arcve_2102	4.646e-39	151.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,2462Q@183980|Archaeoglobi	183980|Archaeoglobi	O	AAA family ATPase, CDC48 subfamily	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
SX1_k127_1067115_4	273068.TTE2189	1.889e-40	153.0	COG0432@1|root,COG0432@2|Bacteria,1V6J7@1239|Firmicutes,24J8G@186801|Clostridia,42GHI@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
SX1_k127_1067115_6	1195236.CTER_0903	8.334e-36	147.0	COG1020@1|root,COG1020@2|Bacteria,1TW32@1239|Firmicutes,24CC9@186801|Clostridia,3WNZ7@541000|Ruminococcaceae	186801|Clostridia	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,adh_short
SX1_k127_1067115_0	385682.AFSL01000012_gene2848	4.888e-129	434.0	COG3401@1|root,COG3401@2|Bacteria,4NFM5@976|Bacteroidetes,2FPSM@200643|Bacteroidia	976|Bacteroidetes	S	candidate rhamnogalacturonan lyase, polysaccharide lyase family 11 protein K01238	-	-	4.2.2.23	ko:K18197	-	-	-	-	ko00000,ko01000	-	PL11	-	-
SX1_k127_1067115_2	880073.Calab_3201	2.013e-73	261.0	COG4198@1|root,COG4198@2|Bacteria,2NNV0@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function (DUF1015)	gdh	-	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	-	R00248	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	DUF1015
SX1_k127_1067115_3	398512.JQKC01000014_gene1628	1.878e-56	207.0	COG0596@1|root,COG0596@2|Bacteria,1U3PB@1239|Firmicutes,24DR6@186801|Clostridia,3WJ6G@541000|Ruminococcaceae	186801|Clostridia	S	Hydrolase, alpha beta domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
SX1_k127_1067115_1	665571.STHERM_c06110	9.04e-82	280.0	COG2461@1|root,COG2461@2|Bacteria,2J7GM@203691|Spirochaetes	203691|Spirochaetes	S	PAS domain	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF1858,DUF438,Hemerythrin,PAS_10
SX1_k127_10783_3	1173022.Cri9333_2984	1.569e-07	59.0	COG2211@1|root,COG2211@2|Bacteria,1G0ZY@1117|Cyanobacteria,1H6Y4@1150|Oscillatoriales	1117|Cyanobacteria	G	COG2211 Na melibiose symporter and related	melB	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX1_k127_10783_0	1379281.AVAG01000011_gene1297	1.658e-118	401.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42MZJ@68525|delta/epsilon subdivisions,2WJK1@28221|Deltaproteobacteria,2M804@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Aldehyde ferredoxin oxidoreductase	aorA	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
SX1_k127_10783_2	930945.SiRe_1359	5.954e-27	120.0	COG1024@1|root,arCOG00239@2157|Archaea,2XSQI@28889|Crenarchaeota	28889|Crenarchaeota	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.116	ko:K15019	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00375	R03045	RC00834	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
SX1_k127_10783_1	1047013.AQSP01000081_gene96	1.247e-76	265.0	COG0489@1|root,COG0489@2|Bacteria,2NNX1@2323|unclassified Bacteria	2|Bacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
SX1_k127_10783_4	946362.XP_004998524.1	0.0006341	44.0	2DCJT@1|root,2S5K8@2759|Eukaryota,3AU7W@33154|Opisthokonta	33154|Opisthokonta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
SX1_k127_1085164_1	1379698.RBG1_1C00001G0936	1.438e-88	296.0	COG1335@1|root,COG1335@2|Bacteria,2NRGH@2323|unclassified Bacteria	2|Bacteria	Q	Isochorismatase family	-	-	3.5.1.110	ko:K09020	ko00240,ko01100,map00240,map01100	-	R09947,R09980	RC02737,RC02738	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
SX1_k127_1085164_7	1538644.KO02_02635	3.462e-06	50.0	COG1012@1|root,COG1012@2|Bacteria,4NFTW@976|Bacteroidetes,1IQEH@117747|Sphingobacteriia	976|Bacteroidetes	C	Aldehyde dehydrogenase family	pruA	-	1.2.1.88,1.5.5.2	ko:K00294,ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh
SX1_k127_1085164_5	1009370.ALO_18025	3.611e-08	59.0	COG0640@1|root,COG0640@2|Bacteria,1VEER@1239|Firmicutes,4H56Y@909932|Negativicutes	909932|Negativicutes	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
SX1_k127_1085164_6	1158292.JPOE01000005_gene232	1.497e-06	53.0	COG0526@1|root,COG0526@2|Bacteria,1N728@1224|Proteobacteria,2VWXC@28216|Betaproteobacteria,1KMTG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	CO	Thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
SX1_k127_1085164_3	555779.Dthio_PD1046	5.879e-50	192.0	COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42N6E@68525|delta/epsilon subdivisions,2WJXG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
SX1_k127_1085164_8	673860.AciM339_0109	3.261e-05	55.0	arCOG02499@1|root,arCOG05978@1|root,arCOG02499@2157|Archaea,arCOG05978@2157|Archaea,2Y724@28890|Euryarchaeota,3F38A@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_1085164_2	398512.JQKC01000001_gene2200	1.115e-79	277.0	COG5297@1|root,COG5297@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase family 6	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Beta-lactamase,CBM60,CBM_2,Cellulase,DUF1593,PSCyt3,fn3
SX1_k127_1085164_0	639282.DEFDS_1187	3.684e-123	413.0	COG0138@1|root,COG0138@2|Bacteria,2GFAQ@200930|Deferribacteres	200930|Deferribacteres	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
SX1_k127_1085164_4	391625.PPSIR1_03133	2.703e-35	145.0	COG2203@1|root,COG3899@1|root,COG4191@1|root,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1R609@1224|Proteobacteria,42MTJ@68525|delta/epsilon subdivisions,2WJYM@28221|Deltaproteobacteria,2Z2WR@29|Myxococcales	28221|Deltaproteobacteria	T	COG0515 Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Pkinase
SX1_k127_1094303_0	545694.TREPR_2694	9.599e-27	120.0	2CFN2@1|root,34AP1@2|Bacteria,2JA1Q@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
SX1_k127_1094303_1	1305737.JAFX01000001_gene3214	1.805e-14	84.0	COG0530@1|root,COG0530@2|Bacteria,4NFBC@976|Bacteroidetes,47PMC@768503|Cytophagia	976|Bacteroidetes	P	K -dependent Na Ca exchanger	yrbG	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
SX1_k127_1114073_2	192875.XP_004346893.1	9.184e-56	198.0	COG0120@1|root,KOG3075@2759|Eukaryota,38HSY@33154|Opisthokonta	33154|Opisthokonta	G	ribose-5-phosphate isomerase activity	RKI1	GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009052,GO:0009058,GO:0009110,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019321,GO:0019362,GO:0019438,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
SX1_k127_1114073_1	247490.KSU1_C0973	2.777e-96	326.0	COG3392@1|root,COG3392@2|Bacteria	2|Bacteria	L	D12 class N6 adenine-specific DNA methyltransferase	-	-	2.1.1.72	ko:K07318	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	MethyltransfD12
SX1_k127_1114073_0	926569.ANT_22340	1.695e-132	434.0	COG2211@1|root,COG2211@2|Bacteria,2G6RZ@200795|Chloroflexi	200795|Chloroflexi	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX1_k127_1124916_1	935948.KE386494_gene943	2.217e-10	64.0	COG1082@1|root,COG1830@1|root,COG1082@2|Bacteria,COG1830@2|Bacteria,1TRGF@1239|Firmicutes,248GM@186801|Clostridia,42FYQ@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Xylose isomerase domain-containing protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SX1_k127_1124916_0	243274.THEMA_09615	4.138e-17	96.0	COG5276@1|root,COG5276@2|Bacteria,2GDIA@200918|Thermotogae	200918|Thermotogae	S	PFAM LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
SX1_k127_11371_1	3656.XP_008453663.1	5.269e-42	167.0	COG4692@1|root,2QTE2@2759|Eukaryota,37IW0@33090|Viridiplantae,3GCM2@35493|Streptophyta,4JD3J@91835|fabids	35493|Streptophyta	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
SX1_k127_11371_0	797209.ZOD2009_20687	6.096e-79	293.0	COG1501@1|root,arCOG03663@2157|Archaea,2XV49@28890|Euryarchaeota,23V0G@183963|Halobacteria	183963|Halobacteria	G	Melibiase	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Melibiase
SX1_k127_11371_6	555079.Toce_1876	0.0001961	53.0	COG0524@1|root,COG0524@2|Bacteria,1UVW9@1239|Firmicutes,25MKQ@186801|Clostridia,42IEM@68295|Thermoanaerobacterales	186801|Clostridia	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
SX1_k127_11371_3	877455.Metbo_1358	7.109e-18	91.0	COG1514@1|root,arCOG01736@2157|Archaea,2XZ2M@28890|Euryarchaeota,23P6A@183925|Methanobacteria	183925|Methanobacteria	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
SX1_k127_11371_4	691883.XP_009497152.1	1.713e-08	66.0	KOG0077@1|root,KOG0077@2759|Eukaryota,38URR@33154|Opisthokonta	33154|Opisthokonta	U	regulation of COPII vesicle coating	SAR1A	GO:0000166,GO:0000266,GO:0000902,GO:0001882,GO:0001883,GO:0002164,GO:0002165,GO:0002168,GO:0002376,GO:0002474,GO:0002478,GO:0002495,GO:0002504,GO:0002790,GO:0003002,GO:0003400,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0005798,GO:0005829,GO:0006810,GO:0006886,GO:0006888,GO:0006900,GO:0006901,GO:0006903,GO:0006996,GO:0006997,GO:0006998,GO:0007005,GO:0007006,GO:0007029,GO:0007154,GO:0007165,GO:0007264,GO:0007275,GO:0007389,GO:0007399,GO:0007507,GO:0007591,GO:0008104,GO:0008150,GO:0008363,GO:0009306,GO:0009653,GO:0009790,GO:0009791,GO:0009792,GO:0009888,GO:0009987,GO:0010256,GO:0010639,GO:0010720,GO:0010769,GO:0010770,GO:0010975,GO:0010976,GO:0012505,GO:0012506,GO:0012507,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0016462,GO:0016528,GO:0016529,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019882,GO:0019884,GO:0019886,GO:0022008,GO:0022603,GO:0022604,GO:0022607,GO:0023052,GO:0030117,GO:0030120,GO:0030127,GO:0030133,GO:0030134,GO:0030135,GO:0030154,GO:0030658,GO:0030659,GO:0030660,GO:0030662,GO:0031090,GO:0031333,GO:0031344,GO:0031346,GO:0031410,GO:0031982,GO:0031984,GO:0032386,GO:0032387,GO:0032388,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032879,GO:0032880,GO:0032940,GO:0032989,GO:0032991,GO:0033036,GO:0033043,GO:0033157,GO:0034613,GO:0034622,GO:0035017,GO:0035050,GO:0035293,GO:0035295,GO:0035459,GO:0035556,GO:0035639,GO:0036094,GO:0040003,GO:0042175,GO:0042303,GO:0042335,GO:0042337,GO:0042886,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043254,GO:0043933,GO:0044085,GO:0044087,GO:0044232,GO:0044233,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0045595,GO:0045597,GO:0045664,GO:0045666,GO:0046903,GO:0046907,GO:0048002,GO:0048070,GO:0048079,GO:0048081,GO:0048087,GO:0048193,GO:0048194,GO:0048199,GO:0048207,GO:0048208,GO:0048209,GO:0048285,GO:0048475,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048568,GO:0048699,GO:0048731,GO:0048814,GO:0048856,GO:0048869,GO:0050767,GO:0050769,GO:0050773,GO:0050775,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051049,GO:0051050,GO:0051051,GO:0051094,GO:0051128,GO:0051129,GO:0051130,GO:0051179,GO:0051222,GO:0051223,GO:0051234,GO:0051239,GO:0051240,GO:0051640,GO:0051641,GO:0051648,GO:0051649,GO:0051650,GO:0051656,GO:0051668,GO:0051716,GO:0051960,GO:0051962,GO:0060284,GO:0060341,GO:0060429,GO:0060627,GO:0060628,GO:0061024,GO:0065003,GO:0065007,GO:0070201,GO:0070727,GO:0070861,GO:0070863,GO:0070971,GO:0071702,GO:0071705,GO:0071840,GO:0072359,GO:0072657,GO:0072659,GO:0090087,GO:0090110,GO:0090113,GO:0090114,GO:0090316,GO:0097110,GO:0097159,GO:0097367,GO:0097708,GO:0098588,GO:0098796,GO:0098805,GO:0098827,GO:0120035,GO:1900006,GO:1901265,GO:1901301,GO:1901303,GO:1901363,GO:1903827,GO:1903829,GO:1904951,GO:1990778,GO:2000026	3.5.1.88	ko:K01462,ko:K07953	ko04141,ko05134,map04141,map05134	M00404	-	-	ko00000,ko00001,ko00002,ko01000,ko04031,ko04131	-	-	-	Arf
SX1_k127_11371_2	1220534.B655_0687	6.358e-42	164.0	COG1641@1|root,arCOG02701@2157|Archaea,2XV3G@28890|Euryarchaeota,23NRK@183925|Methanobacteria	183925|Methanobacteria	S	Belongs to the LarC family	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
SX1_k127_11410_2	545695.TREAZ_1760	5.257e-51	204.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4,Peptidase_S15
SX1_k127_11410_0	109760.SPPG_04284T1	4.375e-91	319.0	COG1055@1|root,KOG2639@2759|Eukaryota	2759|Eukaryota	P	arsenite secondary active transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	ArsB,CitMHS
SX1_k127_11410_1	545695.TREAZ_1760	1.415e-53	211.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4,Peptidase_S15
SX1_k127_1165333_1	67593.Physo143437	0.0001564	51.0	COG1252@1|root,KOG2495@2759|Eukaryota,3QHV7@4776|Peronosporales	4776|Peronosporales	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
SX1_k127_1165333_0	292563.Cyast_0935	5.337e-05	55.0	COG2211@1|root,COG2211@2|Bacteria,1G0ZY@1117|Cyanobacteria	1117|Cyanobacteria	G	COG2211 Na melibiose symporter and related	melB	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX1_k127_1170328_0	211114.JOEF01000033_gene1152	6.609e-16	87.0	COG3459@1|root,COG3459@2|Bacteria,2HQFF@201174|Actinobacteria,4E98C@85010|Pseudonocardiales	201174|Actinobacteria	G	Glycosyl hydrolase 36 superfamily, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_36
SX1_k127_1173576_0	1123242.JH636435_gene1524	1.377e-96	337.0	COG2936@1|root,COG2936@2|Bacteria,2J2G5@203682|Planctomycetes	203682|Planctomycetes	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
SX1_k127_1173576_1	1321778.HMPREF1982_00059	8.858e-46	171.0	COG1574@1|root,COG1574@2|Bacteria,1TQ6G@1239|Firmicutes,24A5F@186801|Clostridia,268Q9@186813|unclassified Clostridiales	186801|Clostridia	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
SX1_k127_1180833_2	1382306.JNIM01000001_gene389	3.109e-18	93.0	COG0454@1|root,COG0456@2|Bacteria,2G95I@200795|Chloroflexi	200795|Chloroflexi	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SX1_k127_1180833_1	530564.Psta_1401	4.209e-65	235.0	COG2017@1|root,COG2017@2|Bacteria,2IWRW@203682|Planctomycetes	203682|Planctomycetes	G	Converts alpha-aldose to the beta-anomer	-	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
SX1_k127_1180833_0	575540.Isop_3325	7.112e-229	765.0	COG0178@1|root,COG0178@2|Bacteria,2IXFK@203682|Planctomycetes	203682|Planctomycetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
SX1_k127_1198514_0	1121468.AUBR01000090_gene747	1.656e-141	456.0	COG0183@1|root,COG0183@2|Bacteria,1TT8U@1239|Firmicutes,24AD9@186801|Clostridia	186801|Clostridia	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	DUF35_N,Thiolase_C,Thiolase_N,ketoacyl-synt
SX1_k127_1198514_1	1121468.AUBR01000090_gene748	1.142e-107	365.0	COG1545@1|root,COG3425@1|root,COG1545@2|Bacteria,COG3425@2|Bacteria,1UDNN@1239|Firmicutes,24DF4@186801|Clostridia	186801|Clostridia	I	3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III_C,DUF35_N,OB_aCoA_assoc
SX1_k127_1198514_4	1184251.TCELL_0551	3.129e-10	65.0	COG2004@1|root,arCOG04182@2157|Archaea,2XQW2@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS24 family	rps24e	-	-	ko:K02974	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S24e
SX1_k127_1198514_3	304371.MCP_2671	8.214e-13	71.0	COG1998@1|root,arCOG04183@2157|Archaea,2XZZ0@28890|Euryarchaeota,2NA60@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS31 family	rps27ae	-	-	ko:K02977	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04147	-	-	-	Ribosomal_S27
SX1_k127_1198514_2	1220534.B655_1451	1.158e-75	261.0	COG0533@1|root,arCOG01183@2157|Archaea,arCOG01185@2157|Archaea,2XT07@28890|Euryarchaeota,23NPI@183925|Methanobacteria	183925|Methanobacteria	LT	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function	-	-	2.3.1.234,2.7.11.1	ko:K15904	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko01001,ko03016	-	-	-	Peptidase_M22,Pkinase,RIO1
SX1_k127_1200318_0	1121918.ARWE01000001_gene187	8.396e-44	170.0	COG3752@1|root,COG3752@2|Bacteria,1MXCP@1224|Proteobacteria,42R9G@68525|delta/epsilon subdivisions,2WMTN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	3-oxo-5-alpha-steroid 4-dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
SX1_k127_1237450_3	5759.rna_EHI_131170-1	4.084e-07	53.0	COG1100@1|root,KOG0087@2759|Eukaryota	2759|Eukaryota	J	GTPase activity	RABL2B	GO:0000001,GO:0000003,GO:0000131,GO:0000166,GO:0000242,GO:0000902,GO:0000904,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005783,GO:0005813,GO:0005814,GO:0005815,GO:0005856,GO:0005929,GO:0005933,GO:0005934,GO:0005935,GO:0006810,GO:0006928,GO:0006996,GO:0007005,GO:0007017,GO:0007018,GO:0007029,GO:0007030,GO:0007275,GO:0007338,GO:0007399,GO:0008150,GO:0008594,GO:0009566,GO:0009653,GO:0009987,GO:0010256,GO:0010970,GO:0012505,GO:0015630,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019953,GO:0022008,GO:0022414,GO:0022607,GO:0030030,GO:0030031,GO:0030154,GO:0030182,GO:0030317,GO:0030427,GO:0030705,GO:0030990,GO:0030992,GO:0031503,GO:0031514,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032989,GO:0032991,GO:0035639,GO:0036064,GO:0036094,GO:0036126,GO:0040011,GO:0042073,GO:0042461,GO:0042995,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0044085,GO:0044422,GO:0044424,GO:0044430,GO:0044441,GO:0044444,GO:0044446,GO:0044450,GO:0044463,GO:0044464,GO:0044703,GO:0044782,GO:0046530,GO:0046907,GO:0048308,GO:0048309,GO:0048311,GO:0048313,GO:0048468,GO:0048666,GO:0048667,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0048870,GO:0051179,GO:0051234,GO:0051640,GO:0051641,GO:0051645,GO:0051646,GO:0051649,GO:0051674,GO:0051704,GO:0060271,GO:0070925,GO:0071840,GO:0097159,GO:0097223,GO:0097225,GO:0097367,GO:0097722,GO:0097729,GO:0099111,GO:0120025,GO:0120031,GO:0120036,GO:0120038,GO:1901265,GO:1901363	-	ko:K07883,ko:K07904,ko:K07931,ko:K07976,ko:K17977	ko04144,ko04961,ko04962,ko04972,map04144,map04961,map04962,map04972	-	-	-	ko00000,ko00001,ko03029,ko04031,ko04131,ko04147	-	-	-	Ras
SX1_k127_1237450_0	262724.TT_C0731	1.193e-60	216.0	COG1351@1|root,COG1351@2|Bacteria,1WIPX@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
SX1_k127_1237450_1	6500.XP_005112956.1	5.35e-44	171.0	2C18V@1|root,2S0X7@2759|Eukaryota,3A7XU@33154|Opisthokonta,3BUAH@33208|Metazoa,3DBU9@33213|Bilateria	33208|Metazoa	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	LigB
SX1_k127_1237450_2	1280694.AUJQ01000003_gene1735	9.493e-26	107.0	COG0436@1|root,COG0436@2|Bacteria,1TQD6@1239|Firmicutes,24969@186801|Clostridia,3NHHR@46205|Pseudobutyrivibrio	186801|Clostridia	E	Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate	dapL	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
SX1_k127_1241544_3	1500890.JQNL01000001_gene2344	1.244e-26	121.0	arCOG08211@1|root,2ZBM3@2|Bacteria,1RIRV@1224|Proteobacteria,1SFXN@1236|Gammaproteobacteria,1X59H@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_1241544_4	344747.PM8797T_23996	6.439e-25	107.0	COG0673@1|root,COG0673@2|Bacteria,2IY6G@203682|Planctomycetes	203682|Planctomycetes	S	dehydrogenases and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
SX1_k127_1241544_1	1142394.PSMK_09090	2.23e-33	147.0	COG0673@1|root,COG0673@2|Bacteria,2J3B9@203682|Planctomycetes	203682|Planctomycetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
SX1_k127_1241544_0	743719.PaelaDRAFT_0458	9.749e-59	224.0	COG1082@1|root,COG1082@2|Bacteria,1V2HT@1239|Firmicutes,4HFBJ@91061|Bacilli,26V9V@186822|Paenibacillaceae	91061|Bacilli	G	Xylulose 5-phosphate 3-epimerase	-	-	5.1.3.22	ko:K03079	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R03244	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	AP_endonuc_2
SX1_k127_1241544_2	1117108.PAALTS15_23610	5.63e-30	132.0	COG2211@1|root,COG2211@2|Bacteria,1TRA5@1239|Firmicutes,4HBAI@91061|Bacilli,26T6N@186822|Paenibacillaceae	91061|Bacilli	G	Na melibiose symporter and related transporters	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
SX1_k127_126575_0	1165094.RINTHH_30	5.35e-05	54.0	COG0500@1|root,COG2226@2|Bacteria,1G2EG@1117|Cyanobacteria,1HJAJ@1161|Nostocales	1117|Cyanobacteria	H	Methyltransferase required for the conversion of 2- phytyl-1,4-beta-naphthoquinol to phylloquinol	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
SX1_k127_1272269_2	1116375.VEJY3_18221	2.263e-08	57.0	COG2050@1|root,COG2050@2|Bacteria,1RBPE@1224|Proteobacteria,1SCN1@1236|Gammaproteobacteria,1XXCQ@135623|Vibrionales	135623|Vibrionales	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
SX1_k127_1272269_0	471223.GWCH70_2496	2.161e-12	77.0	COG0457@1|root,COG0457@2|Bacteria,1V1HX@1239|Firmicutes,4HG5V@91061|Bacilli,1WEFC@129337|Geobacillus	91061|Bacilli	S	Tetratricopeptide repeat	yrrB	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_6,TPR_8
SX1_k127_1272269_1	913325.N799_05975	5.934e-12	79.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,1S0D5@1236|Gammaproteobacteria,1XCC6@135614|Xanthomonadales	135614|Xanthomonadales	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_12
SX1_k127_1279307_4	324057.Pjdr2_5450	4.057e-36	152.0	COG3250@1|root,COG3250@2|Bacteria,1TPK7@1239|Firmicutes,4HBHM@91061|Bacilli,26SJK@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the glycosyl hydrolase 2 family	M1-797	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
SX1_k127_1279307_2	1122925.KB895381_gene3904	2.16e-69	246.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,4HA8K@91061|Bacilli,26TFZ@186822|Paenibacillaceae	91061|Bacilli	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX1_k127_1279307_8	877455.Metbo_0697	3.883e-15	89.0	COG0842@1|root,arCOG01463@2157|Archaea,2Y34U@28890|Euryarchaeota,23PDD@183925|Methanobacteria	183925|Methanobacteria	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
SX1_k127_1279307_5	192952.MM_3190	2.106e-27	124.0	COG1650@1|root,arCOG01616@2157|Archaea,2XUM0@28890|Euryarchaeota,2N9S6@224756|Methanomicrobia	224756|Methanomicrobia	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
SX1_k127_1279307_3	760568.Desku_2713	1.27e-43	167.0	COG5012@1|root,COG5012@2|Bacteria,1V33W@1239|Firmicutes,24J77@186801|Clostridia,266X4@186807|Peptococcaceae	186801|Clostridia	S	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
SX1_k127_1279307_9	387093.SUN_2128	3.138e-05	53.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,42MNF@68525|delta/epsilon subdivisions,2YMW2@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	peptidase M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
SX1_k127_1279307_1	316274.Haur_2748	1.189e-84	303.0	COG1132@1|root,COG1132@2|Bacteria,2G7J5@200795|Chloroflexi,3758C@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SX1_k127_1279307_0	1121957.ATVL01000011_gene3855	8.349e-88	313.0	COG1132@1|root,COG1132@2|Bacteria,4NEAG@976|Bacteroidetes,47JVG@768503|Cytophagia	976|Bacteroidetes	V	ABC transporter transmembrane region	-	-	-	ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
SX1_k127_1279307_7	1459636.NTE_02318	4.612e-23	108.0	COG1378@1|root,arCOG02038@2157|Archaea,41SFR@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Archaeal transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
SX1_k127_1279307_6	304371.MCP_2422	4.216e-27	119.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,2N95J@224756|Methanomicrobia	224756|Methanomicrobia	G	Phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2225	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
SX1_k127_1287074_0	1226325.HMPREF1548_05914	4.052e-21	106.0	COG0407@1|root,COG0407@2|Bacteria,1V4YU@1239|Firmicutes,24FCZ@186801|Clostridia,36QUC@31979|Clostridiaceae	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX1_k127_1287074_1	112098.XP_008613079.1	3.056e-16	90.0	297V5@1|root,2REVD@2759|Eukaryota	2759|Eukaryota	S	WD repeat protein 35. Source PGD	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_1288572_0	273068.TTE1931	8.075e-77	289.0	2EWYX@1|root,33QA8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_1294478_0	877455.Metbo_2336	1.133e-47	184.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,23NWZ@183925|Methanobacteria	183925|Methanobacteria	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
SX1_k127_1296988_0	1121957.ATVL01000009_gene1047	2.621e-34	136.0	COG3384@1|root,COG3384@2|Bacteria,4NFGT@976|Bacteroidetes,47KW5@768503|Cytophagia	976|Bacteroidetes	S	PFAM Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
SX1_k127_1296988_3	553174.HMPREF0659_A6354	9.131e-07	57.0	COG1522@1|root,COG1522@2|Bacteria,4NNH2@976|Bacteroidetes,2FS1F@200643|Bacteroidia	976|Bacteroidetes	K	Transcriptional regulator, AsnC family	lrp	-	-	ko:K03719,ko:K05800	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24
SX1_k127_1296988_2	1286106.MPL1_03543	3.837e-12	69.0	COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,1SCFA@1236|Gammaproteobacteria,461H2@72273|Thiotrichales	72273|Thiotrichales	O	Belongs to the sulfur carrier protein TusA family	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
SX1_k127_1296988_5	1415755.JQLV01000001_gene2529	9.58e-06	53.0	COG1553@1|root,COG1553@2|Bacteria,1N021@1224|Proteobacteria,1S99J@1236|Gammaproteobacteria,1XKEM@135619|Oceanospirillales	135619|Oceanospirillales	P	sulfur relay protein TusD DsrE	tusD	-	-	ko:K07235	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE
SX1_k127_1296988_4	765913.ThidrDRAFT_2033	8.726e-06	53.0	COG2923@1|root,COG2923@2|Bacteria,1N8RV@1224|Proteobacteria,1SD0S@1236|Gammaproteobacteria,1WY53@135613|Chromatiales	135613|Chromatiales	P	Belongs to the DsrF TusC family	dsrF	-	-	ko:K07236	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DrsE
SX1_k127_1296988_6	768671.ThimaDRAFT_2911	0.0002688	48.0	COG2168@1|root,COG2168@2|Bacteria,1NGF3@1224|Proteobacteria,1SGPI@1236|Gammaproteobacteria,1WYI4@135613|Chromatiales	135613|Chromatiales	P	sulfur relay protein TusB DsrH	-	-	-	ko:K07237	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DsrH
SX1_k127_1296988_1	419665.Maeo_0966	4.617e-22	100.0	COG2210@1|root,arCOG02064@2157|Archaea,2XT1G@28890|Euryarchaeota	28890|Euryarchaeota	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
SX1_k127_1303819_1	439235.Dalk_1477	5.107e-85	299.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,42M5J@68525|delta/epsilon subdivisions,2WJAK@28221|Deltaproteobacteria,2MI4X@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM formate C-acetyltransferase glycine radical	-	-	2.3.1.54,4.3.99.4	ko:K00656,ko:K20038	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
SX1_k127_1303819_2	639282.DEFDS_2104	1.718e-75	263.0	COG1180@1|root,COG1180@2|Bacteria,2GFJN@200930|Deferribacteres	200930|Deferribacteres	C	4Fe-4S single cluster domain	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
SX1_k127_1303819_0	573063.Metin_1336	8.23e-103	346.0	COG0409@1|root,arCOG04428@2157|Archaea,2XTJA@28890|Euryarchaeota,23QFJ@183939|Methanococci	183939|Methanococci	O	TIGRFAM hydrogenase expression formation protein HypD	-	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
SX1_k127_1303819_3	5722.XP_001322716.1	5.757e-08	64.0	COG1100@1|root,KOG0074@2759|Eukaryota	2759|Eukaryota	KLT	GTP binding	ARL3	GO:0000139,GO:0000166,GO:0000278,GO:0000281,GO:0000910,GO:0001655,GO:0001763,GO:0001822,GO:0001882,GO:0001883,GO:0002009,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005794,GO:0005813,GO:0005815,GO:0005819,GO:0005856,GO:0005874,GO:0005876,GO:0005881,GO:0005929,GO:0005930,GO:0006810,GO:0006892,GO:0006928,GO:0006996,GO:0007017,GO:0007018,GO:0007049,GO:0007154,GO:0007165,GO:0007166,GO:0007224,GO:0007264,GO:0007275,GO:0007399,GO:0007424,GO:0008017,GO:0008092,GO:0008150,GO:0009653,GO:0009888,GO:0009987,GO:0010970,GO:0012505,GO:0015630,GO:0015631,GO:0016020,GO:0016043,GO:0016192,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0022008,GO:0022402,GO:0022607,GO:0023052,GO:0030030,GO:0030031,GO:0030154,GO:0030182,GO:0030496,GO:0030705,GO:0031090,GO:0031503,GO:0031984,GO:0032391,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032838,GO:0035146,GO:0035147,GO:0035239,GO:0035295,GO:0035556,GO:0035639,GO:0035869,GO:0036064,GO:0036094,GO:0042073,GO:0042461,GO:0042995,GO:0043005,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0044085,GO:0044422,GO:0044424,GO:0044430,GO:0044431,GO:0044441,GO:0044444,GO:0044446,GO:0044463,GO:0044464,GO:0044782,GO:0046530,GO:0046907,GO:0048193,GO:0048468,GO:0048513,GO:0048666,GO:0048699,GO:0048729,GO:0048731,GO:0048754,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0051301,GO:0051641,GO:0051649,GO:0051716,GO:0060271,GO:0060429,GO:0060446,GO:0060541,GO:0060562,GO:0061138,GO:0061640,GO:0065007,GO:0070925,GO:0071840,GO:0072001,GO:0097014,GO:0097159,GO:0097367,GO:0097458,GO:0097730,GO:0097731,GO:0097733,GO:0098588,GO:0098791,GO:0099080,GO:0099081,GO:0099111,GO:0099512,GO:0099513,GO:0099568,GO:0120025,GO:0120031,GO:0120036,GO:0120038,GO:1901265,GO:1901363,GO:1903047	-	ko:K07944,ko:K07977,ko:K11278	-	-	-	-	ko00000,ko03036,ko04031	-	-	-	Arf
SX1_k127_1312843_0	267377.MMP1697	5.343e-171	556.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23QK4@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
SX1_k127_1312843_1	374847.Kcr_1117	5.059e-18	90.0	COG1908@1|root,arCOG02475@2157|Archaea	2157|Archaea	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
SX1_k127_1312843_3	877455.Metbo_0369	1.883e-13	82.0	COG1941@1|root,arCOG02472@2157|Archaea,2XV6A@28890|Euryarchaeota,23NKE@183925|Methanobacteria	183925|Methanobacteria	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	mvhG	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
SX1_k127_1312843_2	246194.CHY_1362	6.823e-14	80.0	COG1035@1|root,COG1145@1|root,COG1035@2|Bacteria,COG1145@2|Bacteria	2|Bacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	etfA	-	1.12.98.1,1.18.1.2,1.19.1.1	ko:K00441,ko:K00528,ko:K03522,ko:K03616	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025,R10159	RC02628	ko00000,ko00001,ko01000,ko04147	-	-	-	ETF,ETF_alpha,Fer4,Fer4_6,Fer4_7,Fer4_9,FrhB_FdhB_C,FrhB_FdhB_N
SX1_k127_1317995_0	697281.Mahau_1243	1.497e-166	547.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,42EQF@68295|Thermoanaerobacterales	186801|Clostridia	P	Heavy metal transport detoxification protein	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
SX1_k127_132042_0	1122147.AUEH01000034_gene675	5.883e-15	88.0	COG2270@1|root,COG2270@2|Bacteria,1TRTH@1239|Firmicutes,4H9VB@91061|Bacilli,3F5D5@33958|Lactobacillaceae	91061|Bacilli	S	Vacuole effluxer Atg22 like	yxiO	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
SX1_k127_1341278_1	1408473.JHXO01000010_gene3609	7.017e-98	329.0	COG1171@1|root,COG1171@2|Bacteria,4NEY2@976|Bacteroidetes,2FX64@200643|Bacteroidia	976|Bacteroidetes	E	Pyridoxal-phosphate dependent enzyme	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SX1_k127_1341278_0	224325.AF_1587	3.634e-139	454.0	COG1850@1|root,arCOG04443@2157|Archaea,2XVBP@28890|Euryarchaeota,245T4@183980|Archaeoglobi	28890|Euryarchaeota	G	Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase	rbcL	-	4.1.1.39,5.3.2.5	ko:K01601,ko:K08965	ko00270,ko00630,ko00710,ko01100,ko01120,ko01200,map00270,map00630,map00710,map01100,map01120,map01200	M00034,M00165,M00166,M00532	R00024,R03140,R07393	RC00172,RC00859,RC02421	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
SX1_k127_1341278_2	926550.CLDAP_22970	5.557e-96	321.0	COG0351@1|root,COG0351@2|Bacteria,2G5R7@200795|Chloroflexi	200795|Chloroflexi	H	PFAM Phosphomethylpyrimidine kinase type-1	thiD	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
SX1_k127_1341278_3	1321778.HMPREF1982_01904	9.003e-90	303.0	COG1814@1|root,COG1814@2|Bacteria,1V4D2@1239|Firmicutes	1239|Firmicutes	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
SX1_k127_1341864_1	1120985.AUMI01000018_gene2912	3.059e-08	62.0	COG3950@1|root,COG3950@2|Bacteria,1VEAP@1239|Firmicutes	1239|Firmicutes	S	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_15
SX1_k127_1341864_0	397291.C804_04337	4.531e-19	101.0	COG1192@1|root,COG1192@2|Bacteria,1UJZ3@1239|Firmicutes,24UJ3@186801|Clostridia	186801|Clostridia	D	Involved in chromosome partitioning	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_1357132_1	386456.JQKN01000001_gene1720	3.122e-51	192.0	COG1355@1|root,arCOG01728@2157|Archaea,2XVYU@28890|Euryarchaeota,23P13@183925|Methanobacteria	183925|Methanobacteria	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
SX1_k127_1357132_0	1121342.AUCO01000005_gene328	3.367e-142	462.0	COG1679@1|root,COG1679@2|Bacteria,1UJDG@1239|Firmicutes,24DTH@186801|Clostridia,36GZJ@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
SX1_k127_1368626_2	929562.Emtol_3303	1.587e-90	312.0	299YG@1|root,2ZAJ3@2|Bacteria,4NGQT@976|Bacteroidetes,47MKG@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_1368626_3	1123277.KB893174_gene5947	7.28e-24	104.0	299YG@1|root,2ZAJ3@2|Bacteria,4NGQT@976|Bacteroidetes,47MKG@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_1368626_1	1131266.ARWQ01000001_gene1124	2.36e-158	507.0	COG0180@1|root,arCOG01887@2157|Archaea,41SDK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
SX1_k127_1368626_0	415426.Hbut_0840	1.111e-167	552.0	COG0480@1|root,arCOG01559@2157|Archaea,2XPV5@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
SX1_k127_1368626_4	1321778.HMPREF1982_03857	4.788e-09	59.0	COG0075@1|root,COG0075@2|Bacteria,1TPS0@1239|Firmicutes,24919@186801|Clostridia,269ZN@186813|unclassified Clostridiales	186801|Clostridia	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
SX1_k127_1368894_17	267377.MMP1230	0.0001243	51.0	COG1665@1|root,arCOG01831@2157|Archaea,2XVY6@28890|Euryarchaeota,23QQY@183939|Methanococci	183939|Methanococci	S	PFAM DNA polymerase, beta domain protein region	-	-	-	ko:K09717	-	-	-	-	ko00000	-	-	-	NTP_transf_2
SX1_k127_1368894_9	216432.CA2559_01870	1.359e-29	123.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	2.3.1.82	ko:K18815	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
SX1_k127_1368894_3	391623.TERMP_00379	9.822e-88	306.0	COG1379@1|root,arCOG04881@2157|Archaea,2XV6K@28890|Euryarchaeota,243BB@183968|Thermococci	183968|Thermococci	S	PFAM PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP_C
SX1_k127_1368894_6	593117.TGAM_2020	1.491e-47	184.0	COG0430@1|root,arCOG04125@2157|Archaea,2XT7I@28890|Euryarchaeota,2438J@183968|Thermococci	183968|Thermococci	J	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	GO:0003674,GO:0003824,GO:0003963,GO:0009975,GO:0016874,GO:0016886,GO:0140098	6.5.1.5	ko:K18105	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
SX1_k127_1368894_12	1094508.Tsac_1845	1.057e-20	97.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1TQ1N@1239|Firmicutes,249WC@186801|Clostridia,42F5V@68295|Thermoanaerobacterales	186801|Clostridia	S	Belongs to the CinA family	cinA	-	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
SX1_k127_1368894_11	1236689.MMALV_05730	8.741e-22	108.0	COG1056@1|root,arCOG00972@2157|Archaea,2XUF7@28890|Euryarchaeota,3F2N0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Cytidylyltransferase-like	nadM	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.7.1	ko:K00952	ko00760,ko01100,map00760,map01100	-	R00137,R03005	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
SX1_k127_1368894_10	1321778.HMPREF1982_01510	3.532e-22	109.0	COG0477@1|root,COG2814@2|Bacteria,1UZKT@1239|Firmicutes,25EHZ@186801|Clostridia,26BZA@186813|unclassified Clostridiales	186801|Clostridia	EGP	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX1_k127_1368894_4	1031288.AXAA01000009_gene728	5.039e-77	269.0	COG2267@1|root,COG2267@2|Bacteria,1TRM1@1239|Firmicutes,247J5@186801|Clostridia,36DXS@31979|Clostridiaceae	186801|Clostridia	I	Alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
SX1_k127_1368894_7	1156937.MFUM_1040003	1.512e-41	163.0	COG1912@1|root,COG1912@2|Bacteria,46VM1@74201|Verrucomicrobia,37G4H@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
SX1_k127_1368894_2	419665.Maeo_0553	1.892e-90	315.0	KOG4482@1|root,arCOG00119@2157|Archaea,2XV24@28890|Euryarchaeota,23Q57@183939|Methanococci	183939|Methanococci	J	Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis	spcS	-	2.9.1.2	ko:K03341	ko00450,ko00970,map00450,map00970	-	R08224	RC02965,RC02966	ko00000,ko00001,ko01000	-	-	-	SepSecS
SX1_k127_1368894_15	862517.HMPREF9225_0404	1.587e-05	55.0	2DMUC@1|root,32TQR@2|Bacteria,1V9Y3@1239|Firmicutes,24QZE@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	CpXC
SX1_k127_1368894_5	1094508.Tsac_1090	5.36e-54	199.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	3.1.3.5	ko:K07025,ko:K08723	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
SX1_k127_1368894_0	112098.XP_008611038.1	1.475e-116	391.0	COG0201@1|root,KOG1373@2759|Eukaryota	2759|Eukaryota	U	protein transport	SEC61A1	GO:0000322,GO:0000323,GO:0000324,GO:0001655,GO:0001700,GO:0001822,GO:0002009,GO:0002376,GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005783,GO:0005784,GO:0005789,GO:0005791,GO:0005829,GO:0005886,GO:0006508,GO:0006511,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006620,GO:0006807,GO:0006810,GO:0006886,GO:0006950,GO:0006952,GO:0006955,GO:0006996,GO:0007029,GO:0007275,GO:0007391,GO:0007399,GO:0007417,GO:0007420,GO:0008104,GO:0008150,GO:0008152,GO:0008258,GO:0008320,GO:0008565,GO:0009056,GO:0009057,GO:0009605,GO:0009607,GO:0009615,GO:0009653,GO:0009790,GO:0009792,GO:0009888,GO:0009892,GO:0009894,GO:0009895,GO:0009987,GO:0010033,GO:0010243,GO:0010256,GO:0010498,GO:0010506,GO:0010507,GO:0010941,GO:0010942,GO:0010959,GO:0012505,GO:0012506,GO:0015031,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0016331,GO:0017038,GO:0019222,GO:0019538,GO:0019941,GO:0021536,GO:0021538,GO:0021986,GO:0022804,GO:0022857,GO:0022884,GO:0030139,GO:0030163,GO:0030176,GO:0030433,GO:0030659,GO:0030666,GO:0030670,GO:0030867,GO:0030900,GO:0030970,GO:0031090,GO:0031204,GO:0031224,GO:0031227,GO:0031323,GO:0031324,GO:0031329,GO:0031330,GO:0031410,GO:0031982,GO:0031984,GO:0032501,GO:0032502,GO:0032527,GO:0032879,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0033554,GO:0034097,GO:0034341,GO:0034613,GO:0034756,GO:0034758,GO:0034759,GO:0034761,GO:0034762,GO:0034764,GO:0034765,GO:0034767,GO:0034976,GO:0036503,GO:0039019,GO:0042175,GO:0042221,GO:0042277,GO:0042335,GO:0042886,GO:0042887,GO:0043021,GO:0043022,GO:0043161,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043269,GO:0043270,GO:0043632,GO:0043900,GO:0043902,GO:0043903,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0044743,GO:0044877,GO:0045047,GO:0045087,GO:0045169,GO:0045184,GO:0045335,GO:0046596,GO:0046598,GO:0046907,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048524,GO:0048598,GO:0048729,GO:0048731,GO:0048793,GO:0048856,GO:0050789,GO:0050792,GO:0050794,GO:0050896,GO:0051049,GO:0051050,GO:0051179,GO:0051234,GO:0051603,GO:0051641,GO:0051649,GO:0051704,GO:0051707,GO:0051716,GO:0055085,GO:0060322,GO:0060429,GO:0065002,GO:0065007,GO:0070727,GO:0070843,GO:0070972,GO:0071256,GO:0071261,GO:0071702,GO:0071704,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072001,GO:0072006,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:0097708,GO:0098586,GO:0098588,GO:0098796,GO:0098805,GO:0098827,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1903513,GO:1903900,GO:1903902,GO:1904062,GO:1904064,GO:1904680	-	ko:K10956	ko03060,ko04141,ko04145,ko05110,map03060,map04141,map04145,map05110	M00401	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.4,3.A.5.8,3.A.5.9	-	-	Plug_translocon,SecY
SX1_k127_1368894_16	877455.Metbo_0800	6.775e-05	53.0	COG1422@1|root,arCOG02673@2157|Archaea,2XSX8@28890|Euryarchaeota,23P4B@183925|Methanobacteria	183925|Methanobacteria	U	Integral membrane protein DUF106	-	-	-	-	-	-	-	-	-	-	-	-	DUF106
SX1_k127_1368894_8	192952.MM_0468	2.883e-36	146.0	COG1738@1|root,arCOG04284@2157|Archaea	2157|Archaea	U	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage	-	-	-	ko:K09125	-	-	-	-	ko00000	-	-	-	Vut_1
SX1_k127_1368894_13	323259.Mhun_1252	2.182e-14	76.0	COG4802@1|root,arCOG01099@2157|Archaea,2Y0XX@28890|Euryarchaeota	28890|Euryarchaeota	C	Ferredoxin thioredoxin reductase catalytic beta chain	-	-	-	-	-	-	-	-	-	-	-	-	FeThRed_B
SX1_k127_1368894_18	548479.HMPREF0573_10784	0.0006157	48.0	COG0375@1|root,COG0375@2|Bacteria,2GQTV@201174|Actinobacteria,4D7CF@85005|Actinomycetales	201174|Actinobacteria	S	Hydrogenase/urease nickel incorporation, metallochaperone, hypA	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
SX1_k127_1368894_14	61273.S3CSY2	1.405e-06	54.0	COG1400@1|root,KOG3198@2759|Eukaryota,3A17G@33154|Opisthokonta,3NWSJ@4751|Fungi,3QURS@4890|Ascomycota,211ZQ@147550|Sordariomycetes,3UR65@5151|Ophiostomatales	4751|Fungi	U	SRP19 protein	SEC65	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005786,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006617,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008312,GO:0009987,GO:0015031,GO:0015833,GO:0016043,GO:0022607,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0034622,GO:0042886,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0065003,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:0097159,GO:1901363,GO:1990904	-	ko:K03105	ko03060,map03060	-	-	-	ko00000,ko00001,ko02044	3.A.5.7,3.A.5.9	-	-	SRP19
SX1_k127_1368894_1	1408424.JHYI01000027_gene4581	3.048e-113	382.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,4HA2G@91061|Bacilli,1ZAY1@1386|Bacillus	91061|Bacilli	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	lcfA	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
SX1_k127_1374306_0	460265.Mnod_2951	1.86e-06	57.0	COG0457@1|root,COG4249@1|root,COG0457@2|Bacteria,COG4249@2|Bacteria,1RKBA@1224|Proteobacteria,2TRAV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
SX1_k127_1377551_0	7739.XP_002610565.1	3.33e-65	245.0	2CMQK@1|root,2QRFD@2759|Eukaryota,39S3T@33154|Opisthokonta,3BEGX@33208|Metazoa,3D0PN@33213|Bilateria,48J4M@7711|Chordata	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_1379847_0	1117108.PAALTS15_17781	1.248e-59	215.0	COG0500@1|root,COG2226@2|Bacteria,1UIRD@1239|Firmicutes,4HIXX@91061|Bacilli,274IF@186822|Paenibacillaceae	91061|Bacilli	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
SX1_k127_1379847_1	941639.BCO26_0252	2.971e-09	68.0	COG0697@1|root,COG0697@2|Bacteria,1UH2I@1239|Firmicutes,4HCFV@91061|Bacilli,1ZCXY@1386|Bacillus	91061|Bacilli	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	gmT1	-	-	-	-	-	-	-	-	-	-	-	EamA
SX1_k127_1379847_2	929562.Emtol_4013	0.0006156	49.0	2ECHI@1|root,336FS@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_1382846_1	1547437.LL06_09845	3.188e-23	111.0	COG0697@1|root,COG0697@2|Bacteria,1RAMR@1224|Proteobacteria,2UPH5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SX1_k127_1382846_0	573063.Metin_0475	2.437e-110	376.0	COG1964@1|root,arCOG00933@2157|Archaea,2XTMK@28890|Euryarchaeota,23QS4@183939|Methanococci	183939|Methanococci	S	PFAM Radical SAM domain protein	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
SX1_k127_1382846_3	399550.Smar_0922	1.025e-13	82.0	COG0704@1|root,arCOG00318@2157|Archaea,2XQIE@28889|Crenarchaeota	28889|Crenarchaeota	K	Phosphate uptake regulator, PhoU	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
SX1_k127_1382846_2	933115.GPDM_11795	2.691e-18	93.0	COG1183@1|root,COG1183@2|Bacteria,1TR44@1239|Firmicutes,4HFUP@91061|Bacilli,26EX6@186818|Planococcaceae	91061|Bacilli	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
SX1_k127_1386066_0	530564.Psta_3964	9.035e-15	78.0	COG3119@1|root,COG3119@2|Bacteria,2IXP1@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	Sulfatase
SX1_k127_1386066_1	556261.HMPREF0240_00122	1.263e-08	66.0	COG0407@1|root,COG0407@2|Bacteria,1UY51@1239|Firmicutes,24DZF@186801|Clostridia	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX1_k127_1420473_0	1121289.JHVL01000022_gene1174	3.872e-11	77.0	COG1615@1|root,COG1615@2|Bacteria,1TQHM@1239|Firmicutes,248PM@186801|Clostridia,36DY1@31979|Clostridiaceae	186801|Clostridia	S	UPF0182 protein	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
SX1_k127_148296_2	411684.HPDFL43_01710	0.0001959	44.0	COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,2TT4K@28211|Alphaproteobacteria,43K8A@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	GM	Polysaccharide biosynthesis protein	capD	-	5.1.3.2	ko:K17716	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00362	R00291	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Polysacc_syn_2C,Polysacc_synt_2
SX1_k127_148296_1	877424.ATWC01000006_gene337	6.038e-62	222.0	COG1086@1|root,COG1086@2|Bacteria,1TPTC@1239|Firmicutes,247YC@186801|Clostridia,27K6Q@186928|unclassified Lachnospiraceae	186801|Clostridia	M	NAD(P)H-binding	pseB	-	4.2.1.115	ko:K15894	ko00520,map00520	-	R09697	RC02609	ko00000,ko00001,ko01000	-	-	-	Polysacc_synt_2
SX1_k127_148296_0	585394.RHOM_00800	1.133e-109	362.0	COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,24862@186801|Clostridia	186801|Clostridia	E	Belongs to the DegT DnrJ EryC1 family	pseC	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
SX1_k127_1499358_1	1220534.B655_0356	6.237e-29	127.0	COG0294@1|root,arCOG01978@2157|Archaea,2XTEW@28890|Euryarchaeota,23NP0@183925|Methanobacteria	183925|Methanobacteria	H	TIGRFAM dihydropteroate synthase-related protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4346,Pterin_bind
SX1_k127_1499358_0	529709.PYCH_07880	3.808e-69	248.0	COG2441@1|root,arCOG04329@2157|Archaea,2XW6E@28890|Euryarchaeota,243JG@183968|Thermococci	183968|Thermococci	C	Protein of unknown function (DUF1464)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1464
SX1_k127_1499358_2	573063.Metin_0214	8.19e-20	94.0	COG2098@1|root,arCOG04705@2157|Archaea,2XY43@28890|Euryarchaeota,23R2M@183939|Methanococci	183939|Methanococci	S	Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD)	mptD	-	4.1.2.25	ko:K09739	ko00790,map00790	-	R03504	RC00721,RC00943	ko00000,ko00001,ko01000	-	-	-	DHNA
SX1_k127_150209_0	697303.Thewi_0321	9.888e-51	183.0	COG1786@1|root,COG1786@2|Bacteria,1V47J@1239|Firmicutes,24H4M@186801|Clostridia	186801|Clostridia	S	Protein of unknown function DUF126	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
SX1_k127_150209_1	1365176.N186_00175	4.611e-05	49.0	arCOG00818@1|root,arCOG00818@2157|Archaea	2157|Archaea	S	AbrB family	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
SX1_k127_1530496_1	768704.Desmer_0505	3.984e-28	121.0	COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia,260C0@186807|Peptococcaceae	186801|Clostridia	P	Part of an ABC transporter complex. Responsible for energy coupling to the transport system	cbiO	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
SX1_k127_1530496_0	1365176.N186_04915	1.122e-31	134.0	COG0619@1|root,arCOG02250@2157|Archaea	2157|Archaea	P	PFAM Cobalt transport protein	-	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
SX1_k127_1530496_3	419665.Maeo_0862	4.992e-06	56.0	COG1617@1|root,arCOG02197@2157|Archaea,2XXWS@28890|Euryarchaeota,23R0B@183939|Methanococci	183939|Methanococci	S	Kinase binding protein CGI-121	-	-	-	-	-	-	-	-	-	-	-	-	CGI-121
SX1_k127_1530496_2	1131266.ARWQ01000018_gene768	3.725e-11	65.0	COG1818@1|root,arCOG00084@2157|Archaea,41SNW@651137|Thaumarchaeota	651137|Thaumarchaeota	S	THUMP domain	-	-	-	ko:K06963	-	-	-	-	ko00000,ko03016	-	-	-	THUMP
SX1_k127_1539795_0	945713.IALB_0948	3.107e-278	859.0	COG0209@1|root,COG0209@2|Bacteria	2|Bacteria	F	ribonucleoside-diphosphate reductase activity	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
SX1_k127_1539795_1	945713.IALB_0232	2.314e-214	676.0	COG1640@1|root,COG1640@2|Bacteria	2|Bacteria	G	4-alpha-glucanotransferase	malQ	GO:0000023,GO:0000025,GO:0003674,GO:0003824,GO:0004133,GO:0004134,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005984,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046352,GO:0055114,GO:0071704,GO:1901575	2.4.1.18,2.4.1.25,3.2.1.196,5.4.99.15	ko:K00700,ko:K00705,ko:K02438,ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R02110,R02111,R05196,R09995	RC00049	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13,GH77	iECIAI1_1343.ECIAI1_3560,iECO111_1330.ECO111_4225,iECO26_1355.ECO26_4504,iEcE24377_1341.EcE24377A_3892,iJN678.malQ,iUMNK88_1353.UMNK88_4184,iYL1228.KPN_03786	Alpha-amylase,Glyco_hydro_77
SX1_k127_1539795_5	1191523.MROS_2106	1.043e-34	138.0	COG4103@1|root,COG4103@2|Bacteria	2|Bacteria	T	Tellurite resistance protein TerB	-	-	-	-	-	-	-	-	-	-	-	-	TerB
SX1_k127_1539795_2	1191523.MROS_2846	1.299e-152	488.0	COG0280@1|root,COG0280@2|Bacteria	2|Bacteria	C	phosphate acetyltransferase	pta	-	1.1.1.40,2.3.1.8	ko:K00029,ko:K00625,ko:K13788	ko00430,ko00620,ko00640,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00172,M00357,M00579	R00216,R00230,R00921	RC00004,RC00105,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,DRTGG,PTA_PTB
SX1_k127_1539795_4	1191523.MROS_2847	3.052e-105	352.0	COG0628@1|root,COG0628@2|Bacteria	2|Bacteria	D	permease	yueF	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K03548	-	-	-	-	ko00000,ko02000	2.A.86.1	-	-	AI-2E_transport
SX1_k127_1539795_3	1191523.MROS_2848	2.07e-115	375.0	COG1236@1|root,COG1236@2|Bacteria	2|Bacteria	J	nucleic acid phosphodiester bond hydrolysis	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_2,Lactamase_B_6,RMMBL
SX1_k127_1561492_5	247633.GP2143_14561	1.315e-15	82.0	COG2211@1|root,COG2211@2|Bacteria	2|Bacteria	G	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX1_k127_1561492_4	1304875.JAFZ01000002_gene297	4.736e-22	103.0	COG0655@1|root,COG0655@2|Bacteria,3TB90@508458|Synergistetes	508458|Synergistetes	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
SX1_k127_1561492_2	293826.Amet_1439	4.658e-41	162.0	COG0508@1|root,COG0508@2|Bacteria	2|Bacteria	C	S-acyltransferase activity	-	-	2.3.1.12,2.7.11.1,3.6.4.13	ko:K00627,ko:K03310,ko:K03578,ko:K12132	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000,ko01001	2.A.25	-	-	2-oxoacid_dh,Biotin_lipoyl
SX1_k127_1561492_3	1333523.L593_08510	2.635e-40	160.0	COG0508@1|root,arCOG01706@2157|Archaea,2XUGY@28890|Euryarchaeota,23V33@183963|Halobacteria	183963|Halobacteria	C	COG0508 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	2-oxoacid_dh
SX1_k127_1561492_1	1047013.AQSP01000144_gene915	3.004e-75	261.0	COG0492@1|root,COG0822@1|root,COG0492@2|Bacteria,COG0822@2|Bacteria,2NPRS@2323|unclassified Bacteria	2|Bacteria	C	NifU-like N terminal domain	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	FAD_binding_2,FAD_oxidored,FeS_assembly_P,NifU_N,Pyr_redox_2,cNMP_binding
SX1_k127_1561492_0	1047013.AQSP01000144_gene916	2.282e-83	280.0	COG1104@1|root,COG1104@2|Bacteria,2NNVR@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
SX1_k127_1601715_0	1382356.JQMP01000003_gene2174	0.0002141	51.0	COG0438@1|root,COG0438@2|Bacteria,2G5N9@200795|Chloroflexi,27XSF@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SX1_k127_1656608_1	1540257.JQMW01000014_gene92	4.735e-52	198.0	COG1533@1|root,COG1533@2|Bacteria,1TRIS@1239|Firmicutes,25CEW@186801|Clostridia,36WUR@31979|Clostridiaceae	186801|Clostridia	L	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SX1_k127_1656608_2	1226325.HMPREF1548_00762	4.777e-28	125.0	2DUH6@1|root,33QMG@2|Bacteria,1VSYZ@1239|Firmicutes,24BUD@186801|Clostridia,36PQK@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_1656608_0	593750.Metfor_2676	2.71e-72	254.0	COG0863@1|root,arCOG00115@2157|Archaea	2157|Archaea	H	methylase	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
SX1_k127_1657975_1	386456.JQKN01000019_gene1316	6.577e-74	257.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,23NSS@183925|Methanobacteria	183925|Methanobacteria	S	Beta-Casp domain	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_7,Lactamase_B_6,RMMBL
SX1_k127_1657975_2	351160.RRC254	1.902e-19	98.0	COG1145@1|root,arCOG02180@2157|Archaea,2XV84@28890|Euryarchaeota,2N9ND@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	fwdF-1	-	-	ko:K00205	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002	-	-	-	Fer4,Fer4_4,Fer4_7
SX1_k127_1657975_3	368408.Tpen_0332	1.101e-17	94.0	arCOG03119@1|root,arCOG03119@2157|Archaea,2XQUD@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
SX1_k127_1657975_0	877455.Metbo_2292	5.748e-87	304.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,23NRF@183925|Methanobacteria	183925|Methanobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
SX1_k127_1657975_4	1540221.JQNI01000002_gene1982	2.424e-07	55.0	COG0697@1|root,COG0697@2|Bacteria,1WIES@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EG	PFAM EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SX1_k127_1658479_2	397288.C806_04149	2.22e-75	262.0	COG0708@1|root,COG0708@2|Bacteria,1TPFB@1239|Firmicutes,24849@186801|Clostridia,27I8Y@186928|unclassified Lachnospiraceae	186801|Clostridia	L	Endonuclease/Exonuclease/phosphatase family	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
SX1_k127_1658479_3	3656.XP_008453474.1	2.648e-37	146.0	COG1100@1|root,KOG0087@2759|Eukaryota,37J63@33090|Viridiplantae,3GG35@35493|Streptophyta,4JE6B@91835|fabids	35493|Streptophyta	U	Ras-related protein RABA6a-like	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005886,GO:0012505,GO:0016020,GO:0031410,GO:0031982,GO:0043226,GO:0043227,GO:0043229,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097708	-	ko:K07976	-	-	-	-	ko00000,ko04031	-	-	-	Ras
SX1_k127_1658479_1	1499967.BAYZ01000076_gene837	2.204e-86	299.0	COG0123@1|root,COG0123@2|Bacteria,2NP8V@2323|unclassified Bacteria	2|Bacteria	BQ	Histone deacetylase domain	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
SX1_k127_1658479_0	589924.Ferp_1748	7.175e-132	443.0	COG0633@1|root,COG3894@1|root,arCOG02035@2157|Archaea,arCOG02842@2157|Archaea,2XVBE@28890|Euryarchaeota,246NQ@183980|Archaeoglobi	183980|Archaeoglobi	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
SX1_k127_1659295_1	96561.Dole_0663	4.376e-36	146.0	COG1280@1|root,COG1280@2|Bacteria,1RJBR@1224|Proteobacteria,42T9G@68525|delta/epsilon subdivisions,2WP76@28221|Deltaproteobacteria,2MKPW@213118|Desulfobacterales	28221|Deltaproteobacteria	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
SX1_k127_1659295_0	452637.Oter_2107	1.26e-189	604.0	COG0034@1|root,COG0034@2|Bacteria,46SSU@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7
SX1_k127_1668030_0	1162668.LFE_2212	6.902e-120	397.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	5.3.1.12	ko:K01812,ko:K02529,ko:K16210	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	2.A.2.5	-	-	DDE_Tnp_ISAZ013,Peripla_BP_3
SX1_k127_1668030_1	933262.AXAM01000139_gene294	3.13e-07	56.0	COG5421@1|root,COG5421@2|Bacteria,1R7NE@1224|Proteobacteria,42M25@68525|delta/epsilon subdivisions,2WKHV@28221|Deltaproteobacteria,2MJVY@213118|Desulfobacterales	28221|Deltaproteobacteria	L	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
SX1_k127_1692863_0	1499967.BAYZ01000066_gene6053	5.775e-93	313.0	COG0111@1|root,COG0111@2|Bacteria	2|Bacteria	EH	4-phosphoerythronate dehydrogenase activity	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
SX1_k127_1692863_1	1499967.BAYZ01000074_gene2142	1.201e-67	240.0	COG2220@1|root,COG2220@2|Bacteria	2|Bacteria	S	N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Lactamase_B_3
SX1_k127_1692863_2	1499689.CCNN01000006_gene645	5.607e-65	228.0	COG0800@1|root,COG0800@2|Bacteria,1TS0F@1239|Firmicutes,248GA@186801|Clostridia,36ETT@31979|Clostridiaceae	186801|Clostridia	G	2-dehydro-3-deoxyphosphogluconate aldolase 4-hydroxy-2-oxoglutarate aldolase	eda	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
SX1_k127_17449_0	1304880.JAGB01000001_gene459	4.647e-263	836.0	COG3408@1|root,COG3408@2|Bacteria,1TPY5@1239|Firmicutes,249U8@186801|Clostridia	186801|Clostridia	G	Alpha-L-rhamnosidase N-terminal domain protein	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
SX1_k127_17449_1	1158614.I592_04103	5.08e-55	207.0	COG2211@1|root,COG2211@2|Bacteria,1TRA5@1239|Firmicutes,4HBAI@91061|Bacilli,4B138@81852|Enterococcaceae	91061|Bacilli	G	MFS/sugar transport protein	-	-	-	ko:K16139,ko:K16248	-	-	-	-	ko00000,ko02000	2.A.2	-	-	MFS_2
SX1_k127_1812254_1	1121897.AUGO01000016_gene1078	2.48e-56	201.0	COG0433@1|root,COG0433@2|Bacteria,4NF3P@976|Bacteroidetes,1HX0B@117743|Flavobacteriia,2NTCA@237|Flavobacterium	976|Bacteroidetes	S	Bacterial protein of unknown function (DUF853)	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
SX1_k127_1812254_0	1347392.CCEZ01000075_gene3079	7.883e-65	235.0	COG1574@1|root,COG1574@2|Bacteria,1TQ6G@1239|Firmicutes,24A5F@186801|Clostridia,36DJ1@31979|Clostridiaceae	186801|Clostridia	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
SX1_k127_1828762_3	1191523.MROS_2009	6.384e-79	269.0	COG1974@1|root,COG1974@2|Bacteria	2|Bacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
SX1_k127_1828762_2	1191523.MROS_1885	3.52e-114	374.0	COG0020@1|root,COG0020@2|Bacteria	2|Bacteria	I	transferase activity, transferring alkyl or aryl (other than methyl) groups	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
SX1_k127_1828762_0	1191523.MROS_1884	0.0	1099.0	COG4775@1|root,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	bamA	GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
SX1_k127_1828762_6	945713.IALB_0498	3.098e-50	184.0	COG2825@1|root,COG2825@2|Bacteria	2|Bacteria	M	unfolded protein binding	ompH	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
SX1_k127_1828762_4	1191523.MROS_1882	2.294e-68	235.0	COG2825@1|root,COG2825@2|Bacteria	2|Bacteria	M	unfolded protein binding	ompH	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
SX1_k127_1828762_1	1191523.MROS_1881	1.438e-145	468.0	COG1044@1|root,COG1044@2|Bacteria	2|Bacteria	M	lipid A biosynthetic process	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
SX1_k127_1828762_5	1191523.MROS_1880	2.534e-61	213.0	COG0764@1|root,COG0774@1|root,COG0764@2|Bacteria,COG0774@2|Bacteria	2|Bacteria	M	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity	fabZ	GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0019171	3.5.1.108,4.2.1.59	ko:K02372,ko:K02535,ko:K13599,ko:K16363	ko00061,ko00540,ko00780,ko01100,ko01212,ko02020,map00061,map00540,map00780,map01100,map01212,map02020	M00060,M00083,M00498,M00572	R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965,R07764,R10117,R10121	RC00166,RC00300,RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004,ko01005,ko02022	-	-	-	FabA,LpxC
SX1_k127_1836053_2	457570.Nther_2817	1.017e-27	113.0	COG1228@1|root,COG1228@2|Bacteria,1TP2J@1239|Firmicutes,24AGR@186801|Clostridia	186801|Clostridia	Q	Belongs to the metallo-dependent hydrolases superfamily. HutI family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
SX1_k127_1836053_0	1379698.RBG1_1C00001G1247	7.458e-90	305.0	COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,2NNXZ@2323|unclassified Bacteria	2|Bacteria	E	Formiminotransferase-cyclodeaminase	ftcD	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K01746,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_C,FTCD_N
SX1_k127_1836053_1	768679.TTX_1659	2.389e-36	146.0	COG0638@1|root,arCOG00970@2157|Archaea,2XQG7@28889|Crenarchaeota	28889|Crenarchaeota	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB1	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
SX1_k127_1836053_4	69014.TK0475	6.521e-05	55.0	COG0269@1|root,arCOG00053@2157|Archaea,2Y670@28890|Euryarchaeota,242WV@183968|Thermococci	183968|Thermococci	G	SIS domain	hps	-	4.1.2.43,5.3.1.27	ko:K13831	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05338,R05339,R09780	RC00377,RC00421,RC00422	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase,SIS
SX1_k127_1836053_3	1033810.HLPCO_000313	2.267e-06	60.0	COG1649@1|root,COG1649@2|Bacteria	2|Bacteria	F	PFAM Uncharacterised BCR, COG1649	-	-	-	ko:K11931	ko02026,map02026	-	-	-	ko00000,ko00001,ko01000	-	-	-	DUF4985,GHL10
SX1_k127_1849176_2	269797.Mbar_A2878	7.363e-25	110.0	arCOG04423@1|root,arCOG04423@2157|Archaea,2XWIR@28890|Euryarchaeota,2NASM@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_1849176_0	579137.Metvu_1395	1.323e-68	254.0	COG0028@1|root,arCOG01998@2157|Archaea,2XT5F@28890|Euryarchaeota,23Q9X@183939|Methanococci	183939|Methanococci	E	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
SX1_k127_1849176_3	272562.CA_C3491	4.969e-16	84.0	COG3871@1|root,COG3871@2|Bacteria,1V6IU@1239|Firmicutes,24G5S@186801|Clostridia,36IY6@31979|Clostridiaceae	186801|Clostridia	S	Pyridoxamine 5'-phosphate oxidase like	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx,Pyrid_ox_like
SX1_k127_1849176_1	1469948.JPNB01000002_gene2784	8.753e-31	126.0	COG1846@1|root,COG1846@2|Bacteria,1V8KT@1239|Firmicutes,24B99@186801|Clostridia,36KPX@31979|Clostridiaceae	186801|Clostridia	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
SX1_k127_1850382_1	882.DVU_2590	1.936e-32	130.0	COG2461@1|root,COG2461@2|Bacteria,1R5J5@1224|Proteobacteria,42QAZ@68525|delta/epsilon subdivisions,2WQTR@28221|Deltaproteobacteria,2M9HN@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Family of unknown function (DUF438)	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF1858,DUF438,Hemerythrin,PAS_10
SX1_k127_1850382_0	1121422.AUMW01000002_gene2121	5.567e-33	130.0	COG1917@1|root,COG1917@2|Bacteria,1UHAE@1239|Firmicutes,24C81@186801|Clostridia	186801|Clostridia	S	Cupin domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SX1_k127_186506_0	633148.Tagg_1151	4.982e-20	93.0	COG1698@1|root,arCOG04308@2157|Archaea,2XQVN@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the UPF0147 family	-	-	-	ko:K09721	-	-	-	-	ko00000	-	-	-	UPF0147
SX1_k127_186506_1	694431.DESACE_01195	8.476e-10	68.0	COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,42MQX@68525|delta/epsilon subdivisions,2WKUP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DNA polymerase	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
SX1_k127_1872917_0	1463821.JOGR01000004_gene2295	1.865e-14	87.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria,4EY01@85014|Glycomycetales	201174|Actinobacteria	Q	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX1_k127_1877470_0	1332071.L581_4376	2.272e-07	62.0	COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,1RS1U@1236|Gammaproteobacteria,404AW@613|Serratia	1236|Gammaproteobacteria	K	acetyltransferase	yghO	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_188151_11	195522.BD01_2032	3.375e-05	50.0	COG1412@1|root,arCOG04312@2157|Archaea,2XZ0Z@28890|Euryarchaeota,2441K@183968|Thermococci	183968|Thermococci	V	Fcf1	-	-	-	ko:K07158	-	-	-	-	ko00000	-	-	-	Fcf1
SX1_k127_188151_6	303518.XP_005754795.1	8.747e-31	127.0	COG1100@1|root,KOG0097@2759|Eukaryota,38EZ9@33154|Opisthokonta,3BBM7@33208|Metazoa,3CZZI@33213|Bilateria,487XT@7711|Chordata,48W16@7742|Vertebrata,4A2JV@7898|Actinopterygii	33208|Metazoa	U	RAB14, member RAS oncogene family	RAB14	GO:0001845,GO:0003674,GO:0003824,GO:0003924,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005769,GO:0005770,GO:0005794,GO:0005802,GO:0006810,GO:0006873,GO:0006885,GO:0006897,GO:0006909,GO:0006950,GO:0006952,GO:0006996,GO:0007033,GO:0007040,GO:0007154,GO:0007165,GO:0007264,GO:0007265,GO:0008150,GO:0009605,GO:0009607,GO:0009617,GO:0009987,GO:0012505,GO:0016043,GO:0016050,GO:0016192,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019725,GO:0022607,GO:0023052,GO:0030003,GO:0030004,GO:0030100,GO:0030139,GO:0030641,GO:0031410,GO:0031982,GO:0031984,GO:0032482,GO:0032879,GO:0035556,GO:0036477,GO:0042592,GO:0042742,GO:0043025,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043277,GO:0044085,GO:0044297,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0045202,GO:0045335,GO:0045851,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051049,GO:0051128,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0051704,GO:0051707,GO:0051716,GO:0055067,GO:0055080,GO:0055082,GO:0060627,GO:0065007,GO:0065008,GO:0070925,GO:0071840,GO:0080171,GO:0090382,GO:0090383,GO:0090386,GO:0090387,GO:0090390,GO:0097458,GO:0097708,GO:0098542,GO:0098657,GO:0098771,GO:0098791	-	ko:K07881	ko04152,map04152	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
SX1_k127_188151_7	339860.Msp_0428	6.791e-30	132.0	COG1767@1|root,arCOG04238@2157|Archaea,2XT6S@28890|Euryarchaeota,23P0Y@183925|Methanobacteria	183925|Methanobacteria	H	ATP dephospho-CoA triphosphoribosyl transferase	citG	-	2.4.2.52	ko:K05966	ko02020,map02020	-	R09675	RC00049,RC00063	ko00000,ko00001,ko01000	-	-	-	CitG
SX1_k127_188151_9	572546.Arcpr_0880	7.556e-15	84.0	COG0250@1|root,arCOG01920@2157|Archaea,2XWGQ@28890|Euryarchaeota,24688@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcription elongation factor Spt5	spt5	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,Spt5-NGN
SX1_k127_188151_8	1041930.Mtc_1253	1.081e-22	101.0	COG0361@1|root,arCOG01179@2157|Archaea,2XXX0@28890|Euryarchaeota,2NA1A@224756|Methanomicrobia	224756|Methanomicrobia	J	Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits	-	-	-	ko:K03236	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	eIF-1a
SX1_k127_188151_0	339860.Msp_0384	3.295e-103	357.0	COG1964@1|root,arCOG00933@2157|Archaea,2XTMK@28890|Euryarchaeota,23NK2@183925|Methanobacteria	183925|Methanobacteria	S	4Fe-4S single cluster domain	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
SX1_k127_188151_2	1437425.CSEC_1228	8.411e-50	192.0	COG0714@1|root,COG0714@2|Bacteria,2JFQ2@204428|Chlamydiae	204428|Chlamydiae	S	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
SX1_k127_188151_1	1283299.AUKG01000001_gene2897	4.45e-101	343.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4CRMB@84995|Rubrobacteria	84995|Rubrobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SX1_k127_188151_3	536227.CcarbDRAFT_2297	4.036e-41	165.0	COG3049@1|root,COG3049@2|Bacteria,1TRTI@1239|Firmicutes,25QB6@186801|Clostridia,36RX5@31979|Clostridiaceae	186801|Clostridia	M	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	CBAH
SX1_k127_188151_4	58344.JOEL01000059_gene3876	7.558e-37	152.0	COG1131@1|root,COG1131@2|Bacteria,2GKI7@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SX1_k127_188151_10	1134474.O59_002697	1.228e-11	76.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,1FH0H@10|Cellvibrio	1236|Gammaproteobacteria	V	ABC-2 family transporter protein	ybhS	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
SX1_k127_188151_5	86416.Clopa_4701	1.939e-36	155.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia,36DTX@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K01990,ko:K11050	ko02010,map02010	M00254,M00298	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.130	-	-	ABC_tran,DUF4162
SX1_k127_1891857_4	679926.Mpet_1807	0.0001602	52.0	COG2404@1|root,arCOG00423@2157|Archaea,2XTAE@28890|Euryarchaeota	28890|Euryarchaeota	S	phosphohydrolase (DHH superfamily)	-	-	-	ko:K07097	-	-	-	-	ko00000	-	-	-	-
SX1_k127_1891857_1	339860.Msp_1406	1.26e-14	79.0	COG4008@1|root,arCOG04853@2157|Archaea,2XX3S@28890|Euryarchaeota,23PIY@183925|Methanobacteria	183925|Methanobacteria	K	methanogenesis marker domain 9	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_1891857_0	706587.Desti_5047	6.111e-120	413.0	COG0745@1|root,COG0784@1|root,COG5002@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BSJ@68525|delta/epsilon subdivisions,2X73B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
SX1_k127_1891857_3	523845.AQXV01000041_gene432	2.484e-06	58.0	COG0746@1|root,arCOG01872@2157|Archaea,2Y6CM@28890|Euryarchaeota,23QZ8@183939|Methanococci	183939|Methanococci	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
SX1_k127_1891857_2	1056495.Calag_1370	5.399e-10	66.0	COG0440@1|root,arCOG00811@2157|Archaea,2XR7F@28889|Crenarchaeota	28889|Crenarchaeota	K	Transcriptional regulator, AbrB family	-	-	-	-	-	-	-	-	-	-	-	-	ACT,ACT_4,MazE_antitoxin,MraZ
SX1_k127_1912320_2	2423.NA23_0205210	1.388e-10	65.0	COG0457@1|root,COG0457@2|Bacteria	2423.NA23_0205210|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_1912320_1	86416.Clopa_2610	1.397e-110	374.0	COG0366@1|root,COG0366@2|Bacteria,1TQFJ@1239|Firmicutes,249Y3@186801|Clostridia,36VG7@31979|Clostridiaceae	186801|Clostridia	G	alpha amylase, catalytic	-	-	3.2.1.133,3.2.1.135,3.2.1.54,3.5.4.33	ko:K01208,ko:K11991	ko00500,ko01100,map00500,map01100	-	R02112,R03122,R10223,R11262	RC00477	ko00000,ko00001,ko01000,ko03016	-	GH13	-	Alpha-amylase,Alpha-amylase_C,DUF1653,Malt_amylase_C
SX1_k127_1912320_0	994573.T472_0206750	4.803e-224	728.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,36DDM@31979|Clostridiaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
SX1_k127_1915570_1	686340.Metal_1709	2.804e-42	164.0	COG0366@1|root,COG0366@2|Bacteria,1PDXT@1224|Proteobacteria	1224|Proteobacteria	G	alpha amylase, catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
SX1_k127_1915570_2	485918.Cpin_2396	1.615e-11	72.0	COG1695@1|root,COG1695@2|Bacteria,4NQBA@976|Bacteroidetes,1ITDN@117747|Sphingobacteriia	976|Bacteroidetes	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	PadR
SX1_k127_1915570_0	865861.AZSU01000005_gene934	1.8e-97	324.0	COG3386@1|root,COG3386@2|Bacteria,1UN4I@1239|Firmicutes,25GWC@186801|Clostridia,36Q09@31979|Clostridiaceae	186801|Clostridia	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_192595_0	765420.OSCT_2121	4.561e-61	226.0	COG3407@1|root,COG3407@2|Bacteria,2GBQ6@200795|Chloroflexi,3760F@32061|Chloroflexia	32061|Chloroflexia	I	PFAM GHMP kinase	-	-	4.1.1.33	ko:K01597	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095	R01121	RC00453	ko00000,ko00001,ko00002,ko01000	-	-	-	-
SX1_k127_192595_1	589924.Ferp_1542	1.486e-37	146.0	COG1257@1|root,arCOG04260@2157|Archaea,2XTV9@28890|Euryarchaeota,245ZK@183980|Archaeoglobi	183980|Archaeoglobi	I	Hydroxymethylglutaryl-CoA reductase, degradative	-	-	1.1.1.88	ko:K00054	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R02081	RC00004,RC00644	ko00000,ko00001,ko01000	-	-	-	HMG-CoA_red
SX1_k127_1931285_0	671065.MetMK1DRAFT_00020890	3.407e-15	78.0	COG1958@1|root,arCOG00998@2157|Archaea,2XR32@28889|Crenarchaeota	28889|Crenarchaeota	K	SMART Like-Sm ribonucleoprotein, eukaryotic and archaea-type, core	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
SX1_k127_1931285_1	768672.Desfe_0181	8.408e-05	53.0	COG0500@1|root,arCOG03773@2157|Archaea,2XQRR@28889|Crenarchaeota	28889|Crenarchaeota	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
SX1_k127_194297_2	933262.AXAM01000039_gene1155	1.134e-21	99.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,42MFX@68525|delta/epsilon subdivisions,2WJ91@28221|Deltaproteobacteria,2MIXG@213118|Desulfobacterales	28221|Deltaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
SX1_k127_194297_0	1035196.HMPREF9998_01664	4.984e-90	314.0	COG0323@1|root,COG0323@2|Bacteria,1TPGK@1239|Firmicutes,24902@186801|Clostridia,25R29@186804|Peptostreptococcaceae	186801|Clostridia	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
SX1_k127_194297_1	1211817.CCAT010000084_gene1832	3.875e-40	158.0	COG1011@1|root,COG1011@2|Bacteria,1UNJF@1239|Firmicutes,24HG6@186801|Clostridia	186801|Clostridia	S	Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
SX1_k127_1943_0	694429.Pyrfu_1605	9.217e-44	166.0	COG1676@1|root,arCOG01701@2157|Archaea,2XQJB@28889|Crenarchaeota	28889|Crenarchaeota	J	Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp	endA	GO:0000213,GO:0000379,GO:0000394,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0004549,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:0140101,GO:1901360	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
SX1_k127_1957312_0	323259.Mhun_1670	1.304e-28	128.0	arCOG04442@1|root,arCOG04442@2157|Archaea,2XXCX@28890|Euryarchaeota,2NASK@224756|Methanomicrobia	224756|Methanomicrobia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
SX1_k127_1957312_1	1041930.Mtc_1029	0.0005231	44.0	COG1821@1|root,arCOG01592@2157|Archaea,2XXPE@28890|Euryarchaeota,2N9JU@224756|Methanomicrobia	224756|Methanomicrobia	S	ATP-grasp domain	-	-	6.3.4.24	ko:K06914	ko00680,map00680	-	R10902	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	ATP-grasp_3
SX1_k127_199087_0	304371.MCP_1816	3.331e-70	256.0	COG1602@1|root,arCOG04269@2157|Archaea,2XTEQ@28890|Euryarchaeota,2NADJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Pfam:DUF650	-	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
SX1_k127_199087_2	1408473.JHXO01000007_gene940	2.244e-17	92.0	COG1082@1|root,COG1082@2|Bacteria,4NKFY@976|Bacteroidetes,2FWXD@200643|Bacteroidia	976|Bacteroidetes	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SX1_k127_199087_3	157072.XP_008865675.1	1.293e-11	78.0	28P40@1|root,2QVQN@2759|Eukaryota	2759|Eukaryota	S	GPI anchor biosynthetic process	CWH43	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_199087_1	1280686.AUKE01000006_gene334	9.887e-40	158.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,4BXEG@830|Butyrivibrio	186801|Clostridia	I	Enoyl-CoA hydratase/isomerase	crt	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
SX1_k127_202770_0	1384056.N787_02440	6.783e-29	117.0	COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,1RMG1@1236|Gammaproteobacteria,1X623@135614|Xanthomonadales	135614|Xanthomonadales	Q	ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX1_k127_202770_1	338966.Ppro_3255	2.592e-24	110.0	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,42SR7@68525|delta/epsilon subdivisions,2WP65@28221|Deltaproteobacteria,43UWG@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	PFAM Maf family protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
SX1_k127_202770_2	395493.BegalDRAFT_3524	8.022e-20	93.0	COG0524@1|root,COG0524@2|Bacteria,1QTMS@1224|Proteobacteria,1RQQY@1236|Gammaproteobacteria,460BF@72273|Thiotrichales	72273|Thiotrichales	G	PFAM pfkB family carbohydrate kinase	-	-	2.7.1.20	ko:K00856	ko00230,ko01100,map00230,map01100	-	R00185	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
SX1_k127_2042813_3	439235.Dalk_0162	2.582e-39	158.0	COG3576@1|root,COG3576@2|Bacteria	2|Bacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF_2,Putative_PNPOx
SX1_k127_2042813_1	439235.Dalk_0163	3.967e-90	307.0	COG1180@1|root,COG1180@2|Bacteria,1QJHU@1224|Proteobacteria,42R2E@68525|delta/epsilon subdivisions,2WMYN@28221|Deltaproteobacteria,2MJPF@213118|Desulfobacterales	1224|Proteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
SX1_k127_2042813_0	439235.Dalk_0164	3.888e-277	875.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,42M5J@68525|delta/epsilon subdivisions,2WJAK@28221|Deltaproteobacteria	1224|Proteobacteria	C	formate C-acetyltransferase glycine radical	-	-	-	-	-	-	-	-	-	-	-	-	PFL-like
SX1_k127_2042813_2	1128421.JAGA01000002_gene864	2.104e-82	284.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX1_k127_208050_6	1189620.AJXL01000107_gene141	6.984e-12	68.0	COG0615@1|root,COG0615@2|Bacteria,4NGSD@976|Bacteroidetes,1I9D3@117743|Flavobacteriia	976|Bacteroidetes	IM	Cytidylyltransferase-like	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like,GHMP_kinases_C
SX1_k127_208050_3	445973.CLOBAR_01807	4.193e-49	193.0	COG1055@1|root,COG1055@2|Bacteria,1TPNN@1239|Firmicutes,2494X@186801|Clostridia,25R4W@186804|Peptostreptococcaceae	186801|Clostridia	P	Arsenical pump membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
SX1_k127_208050_1	1094980.Mpsy_0782	6.067e-97	328.0	COG0598@1|root,arCOG02265@2157|Archaea,2XTRP@28890|Euryarchaeota,2N9K8@224756|Methanomicrobia	224756|Methanomicrobia	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
SX1_k127_208050_0	46681.XP_001736515.1	1.779e-190	609.0	COG0696@1|root,KOG4513@2759|Eukaryota,3XFSQ@554915|Amoebozoa	554915|Amoebozoa	G	BPG-independent PGAM N-terminus (iPGM_N)	-	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,iPGM_N
SX1_k127_208050_4	1347087.CBYO010000022_gene3297	6.515e-41	168.0	COG0477@1|root,COG0477@2|Bacteria,1UHRM@1239|Firmicutes,4ISTP@91061|Bacilli	91061|Bacilli	EGP	Transmembrane secretion effector	-	-	-	ko:K08217	-	-	-	-	br01600,ko00000,ko01504,ko02000	2.A.1.21.1,2.A.1.21.22	-	-	MFS_1
SX1_k127_208050_2	589924.Ferp_0735	1.685e-79	279.0	COG2069@1|root,arCOG01980@2157|Archaea,2XTXS@28890|Euryarchaeota,245TW@183980|Archaeoglobi	183980|Archaeoglobi	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex	cdhD	-	2.1.1.245	ko:K00194	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD
SX1_k127_208050_5	1121116.KB894766_gene303	4.548e-17	82.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VI0I@28216|Betaproteobacteria,4A9NV@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	fadD	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
SX1_k127_210163_7	1120950.KB892780_gene389	4.15e-15	76.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4DN4J@85009|Propionibacteriales	2|Bacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
SX1_k127_210163_3	1047013.AQSP01000094_gene19	4.567e-38	150.0	COG2110@1|root,COG2110@2|Bacteria,2NPPR@2323|unclassified Bacteria	2|Bacteria	S	Appr-1'-p processing enzyme	tfaE	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Caudo_TAP,Macro
SX1_k127_210163_9	877421.AUJT01000019_gene2779	6.029e-05	54.0	COG0241@1|root,COG0241@2|Bacteria,1V6XD@1239|Firmicutes,24KF1@186801|Clostridia,27TJR@186928|unclassified Lachnospiraceae	186801|Clostridia	E	Polynucleotide kinase 3 phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_like
SX1_k127_210163_1	573413.Spirs_0242	1.009e-72	252.0	COG0179@1|root,COG0179@2|Bacteria,2J89U@203691|Spirochaetes	203691|Spirochaetes	Q	fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
SX1_k127_210163_5	368408.Tpen_0548	6.566e-20	92.0	COG4830@1|root,arCOG04305@2157|Archaea,2XQSV@28889|Crenarchaeota	28889|Crenarchaeota	J	Ribosomal protein S26e	rps26e	-	-	ko:K02976	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S26e
SX1_k127_210163_4	399550.Smar_1186	9.675e-23	106.0	COG0558@1|root,arCOG00670@2157|Archaea,2XQZ2@28889|Crenarchaeota	28889|Crenarchaeota	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.39	ko:K17884	-	-	R10464	RC00002,RC00078	ko00000,ko01000	-	-	-	CDP-OH_P_transf
SX1_k127_210163_8	186497.PF1403	2.302e-05	54.0	COG1901@1|root,arCOG01239@2157|Archaea,2XTSB@28890|Euryarchaeota,242WH@183968|Thermococci	183968|Thermococci	J	Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs	trmY	-	2.1.1.257	ko:K16317	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltrn_RNA_2
SX1_k127_210163_0	589924.Ferp_1389	3.673e-99	333.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,246R1@183980|Archaeoglobi	183980|Archaeoglobi	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
SX1_k127_210163_6	1343739.PAP_10270	2.453e-15	82.0	COG0218@1|root,arCOG00355@2157|Archaea,2XTV8@28890|Euryarchaeota,243FK@183968|Thermococci	183968|Thermococci	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
SX1_k127_210446_3	290397.Adeh_2348	1.992e-49	178.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,42M0I@68525|delta/epsilon subdivisions,2WJ6D@28221|Deltaproteobacteria,2YTZV@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans
SX1_k127_210446_2	883113.HMPREF9708_01083	2.3e-53	200.0	COG0428@1|root,COG0428@2|Bacteria,1TP7J@1239|Firmicutes,4HB3R@91061|Bacilli	91061|Bacilli	P	Mediates zinc uptake. May also transport other divalent cations	zupT	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
SX1_k127_210446_1	575590.HMPREF0156_00485	8.597e-83	284.0	COG0428@1|root,COG0428@2|Bacteria,4NGQ8@976|Bacteroidetes	976|Bacteroidetes	P	Mediates zinc uptake. May also transport other divalent cations	zupT	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
SX1_k127_210446_0	1229909.NSED_05490	1.1e-144	489.0	COG0308@1|root,arCOG02969@2157|Archaea,41SJH@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Peptidase family M1 domain	-	-	3.4.11.2	ko:K01256,ko:K13722	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
SX1_k127_210446_4	411483.FAEPRAA2165_01652	5.931e-13	76.0	COG1247@1|root,COG1247@2|Bacteria,1VBV9@1239|Firmicutes,25BJS@186801|Clostridia,3WS6R@541000|Ruminococcaceae	186801|Clostridia	M	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SX1_k127_210446_5	243232.MJ_1505	9.787e-05	45.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,23Q48@183939|Methanococci	183939|Methanococci	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,Helicase_C,ResIII
SX1_k127_2125013_0	1034769.KB910518_gene346	3.902e-183	581.0	COG0001@1|root,COG0001@2|Bacteria,1TPNH@1239|Firmicutes,4IJJ5@91061|Bacilli,26V7W@186822|Paenibacillaceae	91061|Bacilli	H	Aminotransferase class-III	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
SX1_k127_2125013_1	439235.Dalk_1067	8.793e-51	189.0	COG3255@1|root,COG3255@2|Bacteria,1NSW4@1224|Proteobacteria,42YRX@68525|delta/epsilon subdivisions,2WTIM@28221|Deltaproteobacteria,2MMHN@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_2132160_1	2002.JOEQ01000040_gene6071	1.005e-23	107.0	COG2234@1|root,COG2234@2|Bacteria,2GJ67@201174|Actinobacteria	201174|Actinobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
SX1_k127_2132160_0	1280952.HJA_05892	6.765e-115	381.0	COG4948@1|root,COG4948@2|Bacteria,1MU8R@1224|Proteobacteria,2TSS4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the mandelate racemase muconate lactonizing enzyme family	-	-	5.1.1.20,5.5.1.1	ko:K01856,ko:K19802	ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220	M00568	R05300,R05390,R06989,R08116,R09229,R10938	RC00903,RC01038,RC01108,RC01321,RC01356,RC03309	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
SX1_k127_213579_2	1122613.ATUP01000001_gene158	0.0003243	52.0	COG1266@1|root,COG1266@2|Bacteria,1MYYZ@1224|Proteobacteria,2UBB3@28211|Alphaproteobacteria,43Y1Z@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
SX1_k127_213579_1	485918.Cpin_6522	5.854e-128	420.0	COG0150@1|root,COG0150@2|Bacteria,4NE4E@976|Bacteroidetes,1IQ5E@117747|Sphingobacteriia	976|Bacteroidetes	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
SX1_k127_213579_0	579137.Metvu_1749	4.547e-142	464.0	COG0015@1|root,arCOG01747@2157|Archaea,2XUQ5@28890|Euryarchaeota,23QGH@183939|Methanococci	183939|Methanococci	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
SX1_k127_2151179_2	1304284.L21TH_1736	9.88e-35	135.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,36E4P@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SX1_k127_2151179_3	406327.Mevan_1310	2.866e-32	144.0	arCOG04814@1|root,arCOG04814@2157|Archaea,2XVYV@28890|Euryarchaeota	28890|Euryarchaeota	V	COG1002 Type II restriction enzyme, methylase subunits	-	-	-	-	-	-	-	-	-	-	-	-	Eco57I
SX1_k127_2151179_1	889378.Spiaf_0363	4.856e-38	145.0	COG4802@1|root,COG4802@2|Bacteria,2JASV@203691|Spirochaetes	203691|Spirochaetes	C	Ferredoxin thioredoxin reductase catalytic beta chain	-	-	-	-	-	-	-	-	-	-	-	-	FeThRed_B
SX1_k127_2151179_4	744872.Spica_1484	7.143e-20	92.0	COG0695@1|root,COG0695@2|Bacteria,2JB4B@203691|Spirochaetes	203691|Spirochaetes	O	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
SX1_k127_2151179_0	573413.Spirs_3804	6.146e-145	471.0	COG0554@1|root,COG0554@2|Bacteria,2J6GI@203691|Spirochaetes	203691|Spirochaetes	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	-	-	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
SX1_k127_2155075_4	1123508.JH636439_gene482	0.000169	53.0	COG3356@1|root,COG3356@2|Bacteria,2IXDY@203682|Planctomycetes	203682|Planctomycetes	G	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
SX1_k127_2155075_0	935837.JAEK01000066_gene3962	5.024e-192	629.0	COG3250@1|root,COG3250@2|Bacteria,1TS96@1239|Firmicutes,4HBKW@91061|Bacilli,1ZCQ6@1386|Bacillus	91061|Bacilli	G	Glycosyl hydrolases family 2	-	-	3.2.1.25	ko:K01192	ko00511,ko04142,map00511,map04142	-	-	-	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
SX1_k127_2155075_2	1071073.KI530537_gene2477	1.418e-83	286.0	COG3342@1|root,COG3342@2|Bacteria,1TS8U@1239|Firmicutes,4HBYK@91061|Bacilli,1ZCG3@1386|Bacillus	91061|Bacilli	S	Family of unknown function (DUF1028)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1028,PG_binding_2
SX1_k127_2155075_1	316274.Haur_4511	1.12e-154	499.0	COG0334@1|root,COG0334@2|Bacteria,2G5SR@200795|Chloroflexi,374XT@32061|Chloroflexia	32061|Chloroflexia	C	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
SX1_k127_2155075_3	1341155.FSS13T_15540	8.092e-23	101.0	COG0334@1|root,COG0334@2|Bacteria,4NEBH@976|Bacteroidetes,1HX4B@117743|Flavobacteriia,2NT7J@237|Flavobacterium	976|Bacteroidetes	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
SX1_k127_216060_0	368408.Tpen_1719	4.81e-110	371.0	COG1004@1|root,arCOG00253@2157|Archaea,2XQ60@28889|Crenarchaeota	28889|Crenarchaeota	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
SX1_k127_216060_1	224325.AF_1959	2.349e-75	261.0	COG1924@1|root,arCOG02678@2157|Archaea,2XVMQ@28890|Euryarchaeota,245WU@183980|Archaeoglobi	183980|Archaeoglobi	I	BadF/BadG/BcrA/BcrD ATPase family	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
SX1_k127_2177484_3	1041930.Mtc_2471	1.956e-18	87.0	COG1153@1|root,arCOG02674@2157|Archaea,2XXYM@28890|Euryarchaeota,2NB08@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM molydopterin dinucleotide-binding region	fwdD-1	-	1.2.7.12	ko:K00203	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molydop_binding
SX1_k127_2177484_0	573064.Mefer_0243	3.794e-151	490.0	COG1029@1|root,arCOG01499@2157|Archaea,2XTPW@28890|Euryarchaeota,23Q0U@183939|Methanococci	183939|Methanococci	C	TIGRFAM formylmethanofuran dehydrogenase subunit B	-	-	1.2.7.12	ko:K00201	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdopterin
SX1_k127_2177484_4	411464.DESPIG_00980	1.45e-10	69.0	COG2191@1|root,COG2191@2|Bacteria,1MYKY@1224|Proteobacteria,42NIJ@68525|delta/epsilon subdivisions,2WJ0M@28221|Deltaproteobacteria,2M7RP@213115|Desulfovibrionales	28221|Deltaproteobacteria	CH	PFAM Formylmethanofuran dehydrogenase, subunit E region	-	-	1.2.7.12	ko:K11261	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	FmdE,MoCF_biosynth
SX1_k127_2177484_2	420247.Msm_1473	3.022e-39	158.0	COG1235@1|root,arCOG00499@2157|Archaea,2XT48@28890|Euryarchaeota,23NXG@183925|Methanobacteria	183925|Methanobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
SX1_k127_2177484_1	857293.CAAU_1940	7.815e-72	253.0	COG2267@1|root,COG2267@2|Bacteria,1TRM1@1239|Firmicutes,247J5@186801|Clostridia,36DXS@31979|Clostridiaceae	186801|Clostridia	I	Alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
SX1_k127_2177484_5	439481.Aboo_0586	7.062e-08	60.0	arCOG01917@1|root,arCOG01917@2157|Archaea,2Y1UU@28890|Euryarchaeota,3F2X4@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	DZR,Peptidase_M48,zf-ribbon_3,zinc_ribbon_2
SX1_k127_2177484_6	1121344.JHZO01000004_gene1300	1.22e-07	59.0	2DR5I@1|root,33A9E@2|Bacteria,1VM5P@1239|Firmicutes,24UWH@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	DZR,zf-ribbon_3,zinc_ribbon_2
SX1_k127_2177484_7	1366050.N234_10875	0.0002928	51.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2VKH1@28216|Betaproteobacteria,1JZT2@119060|Burkholderiaceae	28216|Betaproteobacteria	T	adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,zinc_ribbon_2
SX1_k127_2183090_4	644282.Deba_1906	9.041e-80	271.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,42MTW@68525|delta/epsilon subdivisions,2WJ0J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	ATPase associated with various cellular activities, AAA_5	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
SX1_k127_2183090_2	644282.Deba_1905	2.386e-102	345.0	COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,42N7R@68525|delta/epsilon subdivisions,2WJBI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	VWA containing CoxE family protein	-	-	-	ko:K09989	-	-	-	-	ko00000	-	-	-	VWA_CoxE
SX1_k127_2183090_1	180332.JTGN01000020_gene1203	1.498e-107	361.0	COG4733@1|root,COG4733@2|Bacteria,1UIP7@1239|Firmicutes,25EPY@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF2961)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2961
SX1_k127_2183090_5	1191523.MROS_1231	4.777e-78	276.0	COG0826@1|root,COG0826@2|Bacteria	2|Bacteria	O	peptidase U32	prtC	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32
SX1_k127_2183090_6	410358.Mlab_0768	3.733e-40	162.0	COG0863@1|root,arCOG00115@2157|Archaea,2XWB2@28890|Euryarchaeota	28890|Euryarchaeota	L	PFAM DNA methylase N-4 N-6 domain protein	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
SX1_k127_2183090_8	1293048.CBMB010000004_gene1968	4.458e-06	57.0	COG3398@1|root,arCOG02611@2157|Archaea,2XX30@28890|Euryarchaeota,23VMW@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24,HTH_5
SX1_k127_2183090_0	880073.Calab_2930	1.155e-149	482.0	COG1830@1|root,COG1830@2|Bacteria,2NPYP@2323|unclassified Bacteria	2|Bacteria	G	DeoC/LacD family aldolase	fbaB	GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016829,GO:0016830,GO:0016832,GO:0042802,GO:0044424,GO:0044444,GO:0044464	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	iETEC_1333.ETEC_2236,iSBO_1134.SBO_0918,iUMNK88_1353.UMNK88_2640	DeoC
SX1_k127_2183090_3	1121091.AUMP01000001_gene539	8.059e-96	327.0	COG1168@1|root,COG1168@2|Bacteria,1TP5G@1239|Firmicutes,4H9PE@91061|Bacilli	91061|Bacilli	E	COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities	patB	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
SX1_k127_2183090_7	1218173.BALCAV_0201580	5.281e-08	59.0	COG5649@1|root,COG5649@2|Bacteria,1VF35@1239|Firmicutes,4HQN0@91061|Bacilli,1ZIJ5@1386|Bacillus	91061|Bacilli	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
SX1_k127_2199343_0	326427.Cagg_3790	4.266e-215	685.0	COG0365@1|root,COG0365@2|Bacteria,2G5KE@200795|Chloroflexi,37599@32061|Chloroflexia	32061|Chloroflexia	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	-	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
SX1_k127_2199343_1	926569.ANT_30140	2.934e-117	391.0	COG1486@1|root,COG1486@2|Bacteria,2G7VR@200795|Chloroflexi	200795|Chloroflexi	G	Family 4 glycosyl hydrolase	-	-	3.2.1.22	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
SX1_k127_2199343_2	1230343.CANP01000029_gene2273	1.503e-33	134.0	COG0662@1|root,COG0662@2|Bacteria,1RJ7D@1224|Proteobacteria,1SBIG@1236|Gammaproteobacteria,1JGNB@118969|Legionellales	118969|Legionellales	G	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SX1_k127_2218038_0	1121904.ARBP01000004_gene987	6.611e-75	268.0	COG4124@1|root,COG4124@2|Bacteria,4NEZG@976|Bacteroidetes,47MNT@768503|Cytophagia	976|Bacteroidetes	G	Glycosyl hydrolase family 26	-	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	Glyco_hydro_26
SX1_k127_2218038_9	1410630.JNKP01000006_gene105	3.482e-18	93.0	COG0519@1|root,COG0519@2|Bacteria,1TPG8@1239|Firmicutes,2487F@186801|Clostridia,27J1Q@186928|unclassified Lachnospiraceae	186801|Clostridia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans
SX1_k127_2218038_6	1173020.Cha6605_0959	8.706e-30	130.0	COG0508@1|root,COG0508@2|Bacteria,1G4MH@1117|Cyanobacteria	1117|Cyanobacteria	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	-	-	-	-	-	-	-	-	-	-	-	-	2-oxoacid_dh
SX1_k127_2218038_4	1131730.BAVI_16962	6.903e-33	134.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1TQ04@1239|Firmicutes,4HGZ0@91061|Bacilli,1ZCKG@1386|Bacillus	91061|Bacilli	M	Belongs to the SIS family. GutQ KpsF subfamily	kdsD	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
SX1_k127_2218038_1	273075.Ta0881m	4.387e-47	174.0	COG0663@1|root,arCOG01849@2157|Archaea,2XWNM@28890|Euryarchaeota	28890|Euryarchaeota	S	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
SX1_k127_2218038_8	572546.Arcpr_1736	7.138e-19	89.0	COG2058@1|root,arCOG04287@2157|Archaea,2XYQ9@28890|Euryarchaeota,2476N@183980|Archaeoglobi	183980|Archaeoglobi	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl12	-	-	ko:K02869	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s
SX1_k127_2218038_2	439481.Aboo_0861	3.776e-45	178.0	COG0244@1|root,arCOG04288@2157|Archaea,2XU7C@28890|Euryarchaeota,3F2JW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl10	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s,Ribosomal_L10
SX1_k127_2218038_7	368408.Tpen_0223	2.89e-25	117.0	COG0081@1|root,arCOG04289@2157|Archaea,2XQ8W@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds directly to 23S rRNA. Probably involved in E site tRNA release	rpl1	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
SX1_k127_2218038_3	647113.Metok_0540	2.228e-44	168.0	COG0080@1|root,arCOG04372@2157|Archaea,2XTJN@28890|Euryarchaeota,23QV5@183939|Methanococci	183939|Methanococci	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rpl11	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
SX1_k127_2218038_5	485913.Krac_9334	7.785e-33	137.0	COG0637@1|root,COG0637@2|Bacteria	2|Bacteria	S	phosphonoacetaldehyde hydrolase activity	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
SX1_k127_2218038_10	1027273.GZ77_10270	1.019e-17	86.0	COG0615@1|root,COG0615@2|Bacteria	2|Bacteria	H	ADP-L-glycero-beta-D-manno-heptose biosynthetic process	-	-	2.7.7.39	ko:K00980	ko00564,map00564	-	R00856	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
SX1_k127_2225185_0	368408.Tpen_0080	3.777e-32	131.0	COG1100@1|root,arCOG06769@2157|Archaea	2157|Archaea	S	Ras of Complex, Roc, domain of DAPkinase	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	COR,LRR_4,LRR_8,Roc
SX1_k127_2225185_1	1303518.CCALI_02107	0.0009153	44.0	COG1543@1|root,COG1543@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 57 family	-	GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576	2.4.1.18	ko:K03406,ko:K16149	ko00500,ko01100,ko01110,ko02020,ko02030,map00500,map01100,map01110,map02020,map02030	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko02035	-	GH57	-	DUF1957,Glyco_hydro_57,Glyco_transf_4,Glycos_transf_1
SX1_k127_2235225_0	1415166.NONO_c52270	9.22e-65	234.0	COG0451@1|root,COG0451@2|Bacteria,2GN90@201174|Actinobacteria,4G6AP@85025|Nocardiaceae	201174|Actinobacteria	GM	Male sterility protein	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase,NAD_binding_10
SX1_k127_2246834_0	384616.Pisl_0346	1.93e-126	415.0	COG0143@1|root,arCOG00810@2157|Archaea,2XPMW@28889|Crenarchaeota	28889|Crenarchaeota	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g
SX1_k127_2265490_0	931626.Awo_c23850	2.489e-96	328.0	COG2309@1|root,COG2309@2|Bacteria,1TP65@1239|Firmicutes,24AR8@186801|Clostridia,25UWD@186806|Eubacteriaceae	186801|Clostridia	E	Psort location Cytoplasmic, score	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
SX1_k127_2265490_1	1300150.EMQU_0587	1.069e-29	129.0	COG0477@1|root,COG2814@2|Bacteria,1TRZB@1239|Firmicutes,4HBXV@91061|Bacilli,4B0JG@81852|Enterococcaceae	91061|Bacilli	EGP	Transmembrane secretion effector	mdt(A)	-	-	ko:K08217	-	-	-	-	br01600,ko00000,ko01504,ko02000	2.A.1.21.1,2.A.1.21.22	-	-	MFS_1,MFS_2,MFS_3
SX1_k127_2268439_1	1457250.BBMO01000002_gene2815	4.95e-09	66.0	COG3398@1|root,arCOG02611@2157|Archaea,2XV4M@28890|Euryarchaeota,23V38@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
SX1_k127_2268439_0	579137.Metvu_0790	2.204e-98	342.0	COG1964@1|root,arCOG00933@2157|Archaea,2XTMK@28890|Euryarchaeota,23QS4@183939|Methanococci	183939|Methanococci	S	PFAM Radical SAM domain protein	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
SX1_k127_2270114_0	1459636.NTE_01818	2.231e-16	85.0	arCOG05900@1|root,arCOG05900@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,LexA_DNA_bind
SX1_k127_2270114_1	416591.Tlet_0937	1.959e-13	83.0	COG1109@1|root,COG1109@2|Bacteria	2|Bacteria	G	phosphoglucosamine mutase activity	pmmB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
SX1_k127_2270114_3	88036.EFJ37126	2.978e-08	64.0	KOG4252@1|root,KOG4252@2759|Eukaryota,37UWU@33090|Viridiplantae,3GPWB@35493|Streptophyta	35493|Streptophyta	U	ADP-ribosylation factor family	-	-	-	ko:K06234	-	-	-	-	ko00000,ko04031,ko04131	-	-	-	Ras
SX1_k127_2270114_2	1147.D082_09190	4.378e-09	57.0	COG1239@1|root,COG1239@2|Bacteria,1G13M@1117|Cyanobacteria,1H4HV@1142|Synechocystis	1117|Cyanobacteria	H	magnesium ion into protoporphyrin IX to yield	chlI	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	Mg_chelatase
SX1_k127_2289522_3	1416759.AYMR01000007_gene904	2.863e-09	61.0	COG1957@1|root,COG1957@2|Bacteria	2|Bacteria	F	ribosylpyrimidine nucleosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	IU_nuc_hydro
SX1_k127_2289522_1	180332.JTGN01000020_gene1191	1.708e-47	185.0	COG0407@1|root,COG0407@2|Bacteria,1W13C@1239|Firmicutes,24TPG@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX1_k127_2289522_0	5476.C4YFV6	5.13e-68	244.0	COG5277@1|root,KOG0676@2759|Eukaryota,38C0D@33154|Opisthokonta,3NWC7@4751|Fungi,3QK5Q@4890|Ascomycota,3RRX1@4891|Saccharomycetes,47CIB@766764|Debaryomycetaceae	4751|Fungi	Z	Belongs to the actin family	ACT1	GO:0000001,GO:0000003,GO:0000011,GO:0000123,GO:0000132,GO:0000142,GO:0000226,GO:0000228,GO:0000278,GO:0000281,GO:0000785,GO:0000790,GO:0000812,GO:0000910,GO:0000912,GO:0000915,GO:0000916,GO:0001300,GO:0001411,GO:0002790,GO:0003006,GO:0003674,GO:0005198,GO:0005200,GO:0005575,GO:0005622,GO:0005623,GO:0005628,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005826,GO:0005829,GO:0005856,GO:0005884,GO:0005933,GO:0005935,GO:0005937,GO:0005938,GO:0006139,GO:0006259,GO:0006281,GO:0006325,GO:0006338,GO:0006464,GO:0006473,GO:0006475,GO:0006725,GO:0006807,GO:0006810,GO:0006887,GO:0006897,GO:0006928,GO:0006950,GO:0006974,GO:0006979,GO:0006996,GO:0007005,GO:0007010,GO:0007017,GO:0007033,GO:0007049,GO:0007114,GO:0007117,GO:0007119,GO:0007163,GO:0007568,GO:0007569,GO:0008104,GO:0008150,GO:0008152,GO:0008360,GO:0009272,GO:0009306,GO:0009653,GO:0009987,GO:0010927,GO:0015031,GO:0015629,GO:0015833,GO:0016020,GO:0016043,GO:0016192,GO:0016569,GO:0016570,GO:0016573,GO:0018193,GO:0018205,GO:0018393,GO:0018394,GO:0019538,GO:0019953,GO:0019954,GO:0022402,GO:0022413,GO:0022414,GO:0022603,GO:0022604,GO:0022607,GO:0030010,GO:0030029,GO:0030036,GO:0030048,GO:0030050,GO:0030154,GO:0030427,GO:0030435,GO:0030437,GO:0030476,GO:0030479,GO:0030705,GO:0030863,GO:0030864,GO:0030865,GO:0030866,GO:0031011,GO:0031032,GO:0031248,GO:0031505,GO:0031974,GO:0031981,GO:0032153,GO:0032155,GO:0032432,GO:0032502,GO:0032505,GO:0032506,GO:0032940,GO:0032989,GO:0032991,GO:0033036,GO:0033202,GO:0033554,GO:0034293,GO:0034599,GO:0034641,GO:0034728,GO:0035267,GO:0036211,GO:0036213,GO:0040001,GO:0040007,GO:0042221,GO:0042244,GO:0042546,GO:0042763,GO:0042764,GO:0042886,GO:0042995,GO:0043044,GO:0043170,GO:0043189,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043332,GO:0043412,GO:0043486,GO:0043543,GO:0043933,GO:0043934,GO:0043935,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044448,GO:0044451,GO:0044454,GO:0044463,GO:0044464,GO:0044703,GO:0044837,GO:0045184,GO:0045229,GO:0046483,GO:0046903,GO:0046907,GO:0048308,GO:0048311,GO:0048468,GO:0048471,GO:0048646,GO:0048856,GO:0048869,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0051179,GO:0051234,GO:0051276,GO:0051286,GO:0051293,GO:0051294,GO:0051301,GO:0051321,GO:0051640,GO:0051641,GO:0051646,GO:0051648,GO:0051649,GO:0051650,GO:0051653,GO:0051656,GO:0051704,GO:0051716,GO:0060303,GO:0061640,GO:0061645,GO:0065007,GO:0065008,GO:0070013,GO:0070590,GO:0070591,GO:0070603,GO:0070726,GO:0070887,GO:0070938,GO:0071554,GO:0071555,GO:0071702,GO:0071704,GO:0071705,GO:0071824,GO:0071840,GO:0071852,GO:0071940,GO:0071944,GO:0071963,GO:0090304,GO:0097346,GO:0098657,GO:0099080,GO:0099081,GO:0099512,GO:0099513,GO:0099515,GO:0099518,GO:0099568,GO:0110085,GO:0120025,GO:0120038,GO:0120104,GO:0120105,GO:0120106,GO:1901360,GO:1901564,GO:1902407,GO:1902410,GO:1902493,GO:1902494,GO:1902562,GO:1902850,GO:1903046,GO:1903047,GO:1903475,GO:1904949,GO:1990234	-	ko:K05692	ko04015,ko04145,ko04210,ko04390,ko04391,ko04510,ko04520,ko04530,ko04611,ko04670,ko04714,ko04745,ko04810,ko04919,ko04921,ko05100,ko05110,ko05130,ko05131,ko05132,ko05164,ko05205,ko05225,ko05410,ko05412,ko05414,ko05416,ko05418,map04015,map04145,map04210,map04390,map04391,map04510,map04520,map04530,map04611,map04670,map04714,map04745,map04810,map04919,map04921,map05100,map05110,map05130,map05131,map05132,map05164,map05205,map05225,map05410,map05412,map05414,map05416,map05418	-	-	-	ko00000,ko00001,ko03019,ko03021,ko03029,ko03036,ko04147,ko04812	-	-	-	Actin
SX1_k127_2289522_2	1408424.JHYI01000019_gene3028	1.041e-12	77.0	COG2120@1|root,COG2120@2|Bacteria,1TV10@1239|Firmicutes,4HFJQ@91061|Bacilli,1ZAZI@1386|Bacillus	91061|Bacilli	S	proteins, LmbE homologs	bshB1	-	-	ko:K01463	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
SX1_k127_229072_1	903818.KI912268_gene1878	1.366e-10	65.0	COG1142@1|root,COG4624@1|root,COG1142@2|Bacteria,COG4624@2|Bacteria	2|Bacteria	C	iron-sulfur cluster assembly	-	-	1.12.7.2	ko:K00533	-	-	R00019	-	ko00000,ko01000	-	-	-	Fe_hyd_lg_C,Fer4,Fer4_6
SX1_k127_229072_0	903818.KI912268_gene1878	4.554e-172	554.0	COG1142@1|root,COG4624@1|root,COG1142@2|Bacteria,COG4624@2|Bacteria	2|Bacteria	C	iron-sulfur cluster assembly	-	-	1.12.7.2	ko:K00533	-	-	R00019	-	ko00000,ko01000	-	-	-	Fe_hyd_lg_C,Fer4,Fer4_6
SX1_k127_2313730_1	572544.Ilyop_0916	9.187e-117	387.0	COG1454@1|root,COG1454@2|Bacteria,3792I@32066|Fusobacteria	32066|Fusobacteria	C	PFAM Iron-containing alcohol dehydrogenase	fucO	-	1.1.1.77	ko:K00048	ko00630,ko00640,ko01120,map00630,map00640,map01120	-	R01781,R02257	RC00087,RC00099	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
SX1_k127_2313730_0	1123070.KB899255_gene1355	1.181e-144	473.0	COG1070@1|root,COG1070@2|Bacteria,46SI1@74201|Verrucomicrobia,2IUMH@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	FGGY family of carbohydrate kinases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FGGY_C,FGGY_N
SX1_k127_2313730_2	439235.Dalk_3032	4.503e-95	329.0	COG1042@1|root,COG1042@2|Bacteria,1R8BC@1224|Proteobacteria,42PM4@68525|delta/epsilon subdivisions,2WM46@28221|Deltaproteobacteria,2MI8H@213118|Desulfobacterales	28221|Deltaproteobacteria	C	CoA binding domain	-	-	6.2.1.13	ko:K01905	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	CoA_binding_2,Succ_CoA_lig
SX1_k127_2313730_3	555088.DealDRAFT_2948	1.305e-11	69.0	COG0716@1|root,COG0716@2|Bacteria,1VF5I@1239|Firmicutes	1239|Firmicutes	C	Flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_5
SX1_k127_2314056_5	926569.ANT_22340	2.195e-11	65.0	COG2211@1|root,COG2211@2|Bacteria,2G6RZ@200795|Chloroflexi	200795|Chloroflexi	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX1_k127_2314056_4	177437.HRM2_16970	1.159e-14	78.0	COG0640@1|root,COG0640@2|Bacteria,1N8M7@1224|Proteobacteria,42U4R@68525|delta/epsilon subdivisions,2WQ3N@28221|Deltaproteobacteria,2MKV5@213118|Desulfobacterales	28221|Deltaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
SX1_k127_2314056_7	419665.Maeo_0899	2.454e-05	50.0	COG1531@1|root,arCOG01302@2157|Archaea,2Y015@28890|Euryarchaeota,23R8W@183939|Methanococci	183939|Methanococci	S	Belongs to the UPF0248 family	-	-	-	ko:K09715	-	-	-	-	ko00000	-	-	-	DUF504
SX1_k127_2314056_1	1183377.Py04_1262	8.143e-75	265.0	COG1084@1|root,arCOG00352@2157|Archaea,2XU5R@28890|Euryarchaeota,2433Q@183968|Thermococci	183968|Thermococci	S	Nucleolar GTP-binding protein 1 (NOG1)	-	-	-	ko:K06943	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	NOG1
SX1_k127_2314056_2	579137.Metvu_0143	3.984e-48	188.0	COG1548@1|root,arCOG04369@2157|Archaea,2XVPP@28890|Euryarchaeota,23Q6R@183939|Methanococci	183939|Methanococci	K	PFAM Hydantoinase oxoprolinase	-	-	2.5.1.131	ko:K07072	ko00680,map00680	-	R11040	RC01372,RC03335	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_A
SX1_k127_2314056_6	339860.Msp_1157	8.32e-10	68.0	COG2054@1|root,arCOG00859@2157|Archaea,2XVEI@28890|Euryarchaeota,23P3Z@183925|Methanobacteria	183925|Methanobacteria	S	aspartate glutamate uridylate kinase	-	-	2.7.4.31	ko:K07144	ko00680,map00680	-	R11039	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
SX1_k127_2314056_3	180281.CPCC7001_179	6.085e-35	143.0	COG0467@1|root,COG0467@2|Bacteria,1G0KY@1117|Cyanobacteria,22RQX@167375|Cyanobium	1117|Cyanobacteria	T	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction	kaiC	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007623,GO:0008150,GO:0008152,GO:0009605,GO:0009649,GO:0009966,GO:0009987,GO:0010646,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019538,GO:0023051,GO:0036211,GO:0042752,GO:0042754,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0048511,GO:0048519,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0070297,GO:0071704,GO:1901564,GO:1902531	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
SX1_k127_2314056_0	5741.EDO78070	4.855e-186	596.0	COG1042@1|root,2QWQW@2759|Eukaryota	2759|Eukaryota	C	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
SX1_k127_2319321_1	436114.SYO3AOP1_0022	2.976e-82	281.0	COG0863@1|root,COG0863@2|Bacteria	2|Bacteria	L	N-4 methylation of cytosine	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase,SNase
SX1_k127_2319321_2	439481.Aboo_0616	6.812e-08	64.0	arCOG00136@1|root,arCOG00136@2157|Archaea,2Y2YV@28890|Euryarchaeota,3F33T@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX1_k127_2319321_0	1123399.AQVE01000001_gene627	1.341e-194	627.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria,45ZSH@72273|Thiotrichales	72273|Thiotrichales	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
SX1_k127_23338_16	399550.Smar_1222	2.02e-27	118.0	COG1474@1|root,arCOG00467@2157|Archaea,2XPZB@28889|Crenarchaeota	28889|Crenarchaeota	L	Involved in regulation of DNA replication	cdc6-2	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_22,Cdc6_C
SX1_k127_23338_21	573063.Metin_0894	1.597e-13	72.0	COG1383@1|root,arCOG01885@2157|Archaea,2Y07I@28890|Euryarchaeota,23R9M@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eS17 family	rps17e	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02962	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17e
SX1_k127_23338_15	1220534.B655_1961	1.903e-29	128.0	COG2106@1|root,arCOG04069@2157|Archaea,2XSZI@28890|Euryarchaeota,23NTH@183925|Methanobacteria	183925|Methanobacteria	S	Putative RNA methyltransferase	-	-	-	ko:K09142	-	-	-	-	ko00000	-	-	-	Methyltrn_RNA_3
SX1_k127_23338_22	273063.STK_04610	6.8e-11	68.0	COG1645@1|root,arCOG00578@2157|Archaea,2XR3I@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Sjogrens syndrome scleroderma autoantigen 1	-	-	-	ko:K07143	-	-	-	-	ko00000	-	-	-	Auto_anti-p27
SX1_k127_23338_8	589924.Ferp_0854	9.679e-69	250.0	COG0621@1|root,arCOG01358@2157|Archaea,2XSVB@28890|Euryarchaeota,2460N@183980|Archaeoglobi	183980|Archaeoglobi	J	MiaB-like tRNA modifying enzyme	-	-	2.8.4.5	ko:K15865	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
SX1_k127_23338_24	693661.Arcve_1874	8.07e-09	67.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,246R1@183980|Archaeoglobi	183980|Archaeoglobi	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
SX1_k127_23338_5	589924.Ferp_1136	2.643e-96	325.0	COG0087@1|root,arCOG04070@2157|Archaea,2XT9B@28890|Euryarchaeota,245SD@183980|Archaeoglobi	183980|Archaeoglobi	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl3	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
SX1_k127_23338_7	1220534.B655_1959	6.211e-72	251.0	COG0469@1|root,arCOG04071@2157|Archaea,2XTXX@28890|Euryarchaeota,23NJ7@183925|Methanobacteria	183925|Methanobacteria	J	50S ribosomal protein L4	rpl4	-	-	ko:K02930	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
SX1_k127_23338_17	529709.PYCH_01390	1.331e-22	99.0	COG0089@1|root,arCOG04072@2157|Archaea,2XYPG@28890|Euryarchaeota,244AA@183968|Thermococci	183968|Thermococci	J	Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome	rpl23	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
SX1_k127_23338_25	529709.PYCH_03090	1.017e-08	61.0	COG1369@1|root,arCOG01365@2157|Archaea,2XX63@28890|Euryarchaeota,2445Q@183968|Thermococci	183968|Thermococci	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp2	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0006139,GO:0006396,GO:0006399,GO:0006464,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051604,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03537	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_Rpp14
SX1_k127_23338_29	930945.SiRe_1268	0.0009916	48.0	COG1325@1|root,arCOG01042@2157|Archaea	2157|Archaea	J	exosome subunit	-	-	-	ko:K07581	-	-	-	-	ko00000	-	-	-	RNA_binding
SX1_k127_23338_11	1041930.Mtc_0349	1.339e-62	220.0	COG1632@1|root,arCOG04209@2157|Archaea,2XTJJ@28890|Euryarchaeota,2N9HN@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eL15 family	rpl15e	-	-	ko:K02877	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L15e
SX1_k127_23338_23	1042877.GQS_10250	1.028e-10	68.0	COG4003@1|root,arCOG05763@2157|Archaea,2Y3NV@28890|Euryarchaeota,2446V@183968|Thermococci	183968|Thermococci	S	Uncharacterized protein conserved in archaea (DUF2095)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2095
SX1_k127_23338_10	877455.Metbo_1780	8.433e-66	235.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,23NWZ@183925|Methanobacteria	183925|Methanobacteria	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
SX1_k127_23338_18	1304883.KI912532_gene2690	5.322e-22	103.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,2VR65@28216|Betaproteobacteria,2KW50@206389|Rhodocyclales	206389|Rhodocyclales	S	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
SX1_k127_23338_27	873449.STRCR_1841	0.0001281	53.0	COG0327@1|root,COG0327@2|Bacteria,1TQ27@1239|Firmicutes,4H9NY@91061|Bacilli	91061|Bacilli	S	Belongs to the GTP cyclohydrolase I type 2 NIF3 family	yqfO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	NIF3
SX1_k127_23338_14	1506994.JNLQ01000002_gene3287	5.637e-33	132.0	COG0537@1|root,COG0537@2|Bacteria,1V9ZJ@1239|Firmicutes,24JCW@186801|Clostridia,4BZGA@830|Butyrivibrio	186801|Clostridia	FG	Scavenger mRNA decapping enzyme C-term binding	hit	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
SX1_k127_23338_12	1343739.PAP_05760	1.126e-60	228.0	COG0329@1|root,arCOG04172@2157|Archaea,2XSZX@28890|Euryarchaeota,2434Q@183968|Thermococci	183968|Thermococci	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
SX1_k127_23338_3	1499967.BAYZ01000180_gene4413	3.771e-165	529.0	28IMC@1|root,2Z8MV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_23338_13	523850.TON_1355	9.862e-48	198.0	COG1404@1|root,arCOG00702@2157|Archaea,2XTGN@28890|Euryarchaeota,24359@183968|Thermococci	183968|Thermococci	O	Serine protease with a broad substrate specificity	-	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005509,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0070011,GO:0071704,GO:0140096,GO:1901564	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PPC,Peptidase_S8
SX1_k127_23338_0	1343739.PAP_02550	5.178e-212	675.0	COG1274@1|root,arCOG05865@2157|Archaea,2XUU1@28890|Euryarchaeota,24380@183968|Thermococci	183968|Thermococci	C	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
SX1_k127_23338_28	386456.JQKN01000002_gene2750	0.0001686	48.0	COG4068@1|root,arCOG04390@2157|Archaea,2Y19A@28890|Euryarchaeota	28890|Euryarchaeota	S	Uncharacterized protein containing a Zn-ribbon (DUF2116)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2116
SX1_k127_23338_9	573064.Mefer_0785	2.323e-66	250.0	COG1384@1|root,arCOG00485@2157|Archaea,2XTR5@28890|Euryarchaeota,23Q0A@183939|Methanococci	183939|Methanococci	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
SX1_k127_23338_2	391623.TERMP_00675	4.907e-187	602.0	COG1245@1|root,arCOG00187@2157|Archaea,2XSZE@28890|Euryarchaeota,242JH@183968|Thermococci	183968|Thermococci	E	Possible Fer4-like domain in RNase L inhibitor, RLI	-	-	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,RLI
SX1_k127_23338_4	1151117.AJLF01000001_gene958	5.465e-112	375.0	COG0452@1|root,arCOG01704@2157|Archaea,2XTZK@28890|Euryarchaeota,242ZD@183968|Thermococci	183968|Thermococci	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
SX1_k127_23338_20	410359.Pcal_0942	9.082e-14	86.0	COG1389@1|root,arCOG01165@2157|Archaea,2XPVY@28889|Crenarchaeota	28889|Crenarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	FbpA,HATPase_c,HATPase_c_3,Topo-VIb_trans
SX1_k127_23338_6	2850.Phatr24838	2.65e-90	311.0	COG1697@1|root,KOG2795@2759|Eukaryota,2XB6W@2836|Bacillariophyta	2836|Bacillariophyta	L	DNA topoisomerase type II (ATP-hydrolyzing) activity	-	-	-	ko:K10878	ko04113,map04113	-	-	-	ko00000,ko00001,ko03400	-	-	-	TP6A_N
SX1_k127_23338_19	1184267.A11Q_199	6.305e-19	95.0	COG1100@1|root,COG1100@2|Bacteria,1R6NS@1224|Proteobacteria,42NIX@68525|delta/epsilon subdivisions,2MSWB@213481|Bdellovibrionales,2WJ44@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	ADP-ribosylation factor family	mglA	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf,Ras
SX1_k127_23338_1	1459636.NTE_03216	1.516e-199	638.0	COG0525@1|root,arCOG00808@2157|Archaea,41SBK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Anticodon-binding domain of tRNA	-	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
SX1_k127_23360_6	6238.CBG21954	0.0004779	53.0	KOG0800@1|root,KOG0800@2759|Eukaryota,39512@33154|Opisthokonta,3C9VK@33208|Metazoa,3DR07@33213|Bilateria,40J7Z@6231|Nematoda,1M2J5@119089|Chromadorea,40X9I@6236|Rhabditida	33208|Metazoa	O	ubiquitin-protein transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_23360_2	908612.HMPREF9720_1814	3.632e-37	156.0	COG0477@1|root,COG2814@2|Bacteria,4NGAV@976|Bacteroidetes,2G0JU@200643|Bacteroidia	976|Bacteroidetes	EGP	Transmembrane secretion effector	-	-	-	ko:K08217	-	-	-	-	br01600,ko00000,ko01504,ko02000	2.A.1.21.1,2.A.1.21.22	-	-	MFS_1,MFS_3
SX1_k127_23360_0	13035.Dacsa_1566	1.614e-88	308.0	COG2059@1|root,COG2059@2|Bacteria,1G37Z@1117|Cyanobacteria	1117|Cyanobacteria	P	TIGRFAM chromate transporter, chromate ion transporter (CHR) family	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
SX1_k127_23360_3	696281.Desru_3130	1.494e-17	93.0	COG1082@1|root,COG1082@2|Bacteria,1V81Y@1239|Firmicutes,24NI1@186801|Clostridia	186801|Clostridia	G	Xylose isomerase-like TIM barrel	-	-	5.1.3.38	ko:K21909	-	-	-	-	ko00000,ko01000	-	-	-	AP_endonuc_2
SX1_k127_23360_1	639282.DEFDS_0343	4.292e-51	198.0	COG0436@1|root,COG0436@2|Bacteria,2GEJ2@200930|Deferribacteres	200930|Deferribacteres	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
SX1_k127_23360_5	469371.Tbis_0358	1.415e-10	69.0	COG2030@1|root,COG2030@2|Bacteria,2IFCJ@201174|Actinobacteria,4E4UR@85010|Pseudonocardiales	201174|Actinobacteria	I	dehydratase	hadB	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
SX1_k127_23360_7	436229.JOEH01000005_gene3077	0.0009008	48.0	COG2030@1|root,COG2030@2|Bacteria,2GMVC@201174|Actinobacteria,2NI8T@228398|Streptacidiphilus	201174|Actinobacteria	I	N-terminal half of MaoC dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N
SX1_k127_23360_4	1174504.AJTN02000206_gene3460	7.724e-14	79.0	COG2030@1|root,COG2030@2|Bacteria,1V7QY@1239|Firmicutes,4HJBV@91061|Bacilli,1ZHJM@1386|Bacillus	91061|Bacilli	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
SX1_k127_2341993_0	96561.Dole_1061	9.438e-33	138.0	COG1073@1|root,COG1073@2|Bacteria,1RBV1@1224|Proteobacteria,42M9M@68525|delta/epsilon subdivisions,2WM64@28221|Deltaproteobacteria,2MJJ0@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Serine aminopeptidase, S33	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
SX1_k127_2341993_1	221109.22776362	2.43e-21	103.0	COG1024@1|root,COG1024@2|Bacteria,1TQ2V@1239|Firmicutes,4HBT0@91061|Bacilli,23MVQ@182709|Oceanobacillus	91061|Bacilli	I	Enoyl-CoA hydratase/isomerase	phaB	GO:0003674,GO:0003824,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006635,GO:0006636,GO:0008150,GO:0008152,GO:0008610,GO:0009056,GO:0009058,GO:0009062,GO:0009987,GO:0016042,GO:0016053,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016860,GO:0016863,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033559,GO:0034017,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:0072330,GO:1901575,GO:1901576	5.3.3.14,5.3.3.18	ko:K15866,ko:K18474	ko00061,ko00360,ko01120,map00061,map00360,map01120	-	R07639,R09837,R09839	RC00004,RC00326,RC01078,RC02689,RC03003	ko00000,ko00001,ko01000,ko01004	-	-	-	ECH_1
SX1_k127_2341993_2	608506.COB47_1883	1.668e-07	57.0	COG2006@1|root,COG2006@2|Bacteria,1TRYQ@1239|Firmicutes,24966@186801|Clostridia,42EZW@68295|Thermoanaerobacterales	186801|Clostridia	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
SX1_k127_2351048_1	1236517.BAKO01000008_gene140	1.105e-13	78.0	COG2020@1|root,COG2020@2|Bacteria,4NKY4@976|Bacteroidetes,2FRGJ@200643|Bacteroidia	976|Bacteroidetes	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
SX1_k127_2351048_0	1499967.BAYZ01000095_gene4068	4.194e-75	263.0	COG0407@1|root,COG0407@2|Bacteria,2NRD5@2323|unclassified Bacteria	2|Bacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
SX1_k127_2363355_0	269797.Mbar_A0714	0.0	1014.0	COG1048@1|root,arCOG01697@2157|Archaea,2XTIZ@28890|Euryarchaeota,2NAHN@224756|Methanomicrobia	224756|Methanomicrobia	C	Aconitase C-terminal domain	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0714	Aconitase,Aconitase_C
SX1_k127_2363355_5	1121396.KB893058_gene2553	1.534e-103	347.0	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,42N2F@68525|delta/epsilon subdivisions,2WIZ8@28221|Deltaproteobacteria,2MIW8@213118|Desulfobacterales	28221|Deltaproteobacteria	C	FMN-dependent dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_dh
SX1_k127_2363355_4	1158318.ATXC01000001_gene942	1.733e-114	383.0	COG0045@1|root,COG0045@2|Bacteria,2G3VC@200783|Aquificae	200783|Aquificae	C	ATP citrate lyase citrate-binding	-	-	2.3.3.8	ko:K15231	ko00020,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00720,map01100,map01110,map01120,map01130,map01200	M00173	R00352	RC00004,RC00067	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Citrate_bind
SX1_k127_2363355_1	868864.Dester_1134	1.564e-231	731.0	COG0074@1|root,COG0372@1|root,COG0074@2|Bacteria,COG0372@2|Bacteria,2G3P0@200783|Aquificae	200783|Aquificae	C	ATP-citrate synthase (ATP-citrate (Pro-S-)-lyase)(Citrate cleavage enzyme)	-	-	2.3.3.8	ko:K15230	ko00020,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00720,map01100,map01110,map01120,map01130,map01200	M00173	R00352	RC00004,RC00067	ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt,Ligase_CoA
SX1_k127_2363355_2	1047013.AQSP01000111_gene1664	1.109e-183	582.0	COG0473@1|root,COG0473@2|Bacteria,2NP0Z@2323|unclassified Bacteria	2|Bacteria	CE	Isocitrate/isopropylmalate dehydrogenase	icd	-	1.1.1.41,1.1.1.85	ko:K00030,ko:K00052	ko00020,ko00290,ko00660,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00290,map00660,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00432,M00535	R00709,R00994,R04426,R10052	RC00084,RC00114,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
SX1_k127_2363355_3	1183377.Py04_0863	1.32e-163	526.0	COG2403@1|root,arCOG01229@2157|Archaea,2XVYH@28890|Euryarchaeota,24343@183968|Thermococci	183968|Thermococci	S	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
SX1_k127_2366953_1	933262.AXAM01000005_gene2471	8.277e-28	117.0	COG1545@1|root,COG1545@2|Bacteria,1NPAR@1224|Proteobacteria,42WW8@68525|delta/epsilon subdivisions,2WSYD@28221|Deltaproteobacteria,2MM8Q@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
SX1_k127_2366953_0	933262.AXAM01000005_gene2470	4.918e-116	387.0	COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,42N6X@68525|delta/epsilon subdivisions,2WJIE@28221|Deltaproteobacteria,2MK14@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
SX1_k127_236872_1	1382305.AZUC01000047_gene1013	2.538e-51	192.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli,26E4T@186818|Planococcaceae	91061|Bacilli	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iYO844.BSU15910	adh_short_C2
SX1_k127_236872_2	500635.MITSMUL_05004	3.965e-11	73.0	COG1028@1|root,COG1028@2|Bacteria,1TREX@1239|Firmicutes,4H1ZP@909932|Negativicutes	909932|Negativicutes	IQ	Oxidoreductase, short chain dehydrogenase reductase family protein	fabG2	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
SX1_k127_236872_0	639282.DEFDS_0188	1.285e-60	218.0	COG0846@1|root,COG0846@2|Bacteria,2GFEB@200930|Deferribacteres	200930|Deferribacteres	K	Sir2 family	-	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
SX1_k127_2398567_0	439292.Bsel_3105	1.204e-09	62.0	COG0243@1|root,COG0243@2|Bacteria,1TPZG@1239|Firmicutes	1239|Firmicutes	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.3,1.8.5.5	ko:K07306,ko:K08352	ko00920,ko01120,map00920,map01120	-	R09501,R10149	RC02555,RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.3,5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
SX1_k127_2418898_6	526227.Mesil_0236	1.329e-21	104.0	COG2605@1|root,COG2605@2|Bacteria,1WKER@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	COGs COG2605 kinase related to galactokinase and mevalonate kinase	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
SX1_k127_2418898_5	27288.XP_003675726.1	2.941e-28	121.0	KOG0084@1|root,KOG0084@2759|Eukaryota,38DXZ@33154|Opisthokonta,3NUNU@4751|Fungi,3QSH5@4890|Ascomycota,3RT74@4891|Saccharomycetes,3RXZ3@4893|Saccharomycetaceae	4751|Fungi	U	to Saccharomyces cerevisiae YPT1 (YFL038C)	ypt1	GO:0000045,GO:0000139,GO:0000149,GO:0000407,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005783,GO:0005789,GO:0005794,GO:0005795,GO:0005801,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0006810,GO:0006886,GO:0006888,GO:0006890,GO:0006900,GO:0006906,GO:0006914,GO:0006996,GO:0007033,GO:0007154,GO:0007165,GO:0007264,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009966,GO:0009987,GO:0010646,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016050,GO:0016070,GO:0016192,GO:0016197,GO:0016236,GO:0016462,GO:0016482,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019220,GO:0019222,GO:0019439,GO:0022406,GO:0022411,GO:0022607,GO:0023051,GO:0023052,GO:0031090,GO:0031323,GO:0031410,GO:0031982,GO:0031984,GO:0032258,GO:0032456,GO:0032984,GO:0033036,GO:0033365,GO:0034497,GO:0034498,GO:0034613,GO:0034622,GO:0034641,GO:0034655,GO:0035493,GO:0035494,GO:0035556,GO:0042147,GO:0042175,GO:0042325,GO:0042886,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043549,GO:0043624,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046483,GO:0046700,GO:0046907,GO:0048193,GO:0048194,GO:0048211,GO:0048278,GO:0048284,GO:0048583,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051338,GO:0051640,GO:0051641,GO:0051649,GO:0051716,GO:0061024,GO:0061025,GO:0061709,GO:0061912,GO:0061919,GO:0065003,GO:0065007,GO:0065009,GO:0070727,GO:0070925,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072665,GO:0080134,GO:0080135,GO:0090114,GO:0090174,GO:0090304,GO:0097708,GO:0098588,GO:0098791,GO:0098827,GO:0140056,GO:1900101,GO:1901360,GO:1901361,GO:1901575,GO:1903008,GO:1905037,GO:1905897,GO:1990261	-	ko:K07874	ko05134,map05134	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
SX1_k127_2418898_7	694440.JOMF01000004_gene1305	1.719e-19	100.0	COG0207@1|root,arCOG03214@2157|Archaea,2XTCY@28890|Euryarchaeota,2NA4V@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the thymidylate synthase family. Archaeal- type ThyA subfamily	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
SX1_k127_2418898_3	647113.Metok_0978	5.648e-33	136.0	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,23QK3@183939|Methanococci	183939|Methanococci	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019774,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
SX1_k127_2418898_1	694429.Pyrfu_0939	3.872e-56	207.0	COG0024@1|root,arCOG01001@2157|Archaea,2XPVJ@28889|Crenarchaeota	28889|Crenarchaeota	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
SX1_k127_2418898_0	589924.Ferp_1526	1.458e-122	407.0	COG0017@1|root,arCOG00406@2157|Archaea,2XTRE@28890|Euryarchaeota,2460D@183980|Archaeoglobi	183980|Archaeoglobi	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.23	ko:K09759	ko00970,map00970	M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
SX1_k127_2418898_4	374847.Kcr_1404	1.689e-31	127.0	COG1990@1|root,arCOG04228@2157|Archaea	2157|Archaea	S	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.1.1.29	ko:K04794	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	PTH2
SX1_k127_2418898_2	269797.Mbar_A3206	4.374e-47	181.0	COG0585@1|root,arCOG04252@2157|Archaea,2XUTK@28890|Euryarchaeota,2N928@224756|Methanomicrobia	224756|Methanomicrobia	J	Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs	truD	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
SX1_k127_2429540_2	1385935.N836_19955	1.872e-09	64.0	COG3871@1|root,COG3871@2|Bacteria,1GDRX@1117|Cyanobacteria	1117|Cyanobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
SX1_k127_2429540_1	1209989.TepiRe1_0325	4.468e-19	92.0	COG5012@1|root,COG5012@2|Bacteria,1V33W@1239|Firmicutes,24J77@186801|Clostridia,42GH6@68295|Thermoanaerobacterales	186801|Clostridia	S	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
SX1_k127_2461074_0	479434.Sthe_0784	5.809e-72	249.0	COG0498@1|root,COG0498@2|Bacteria,2G5RK@200795|Chloroflexi,27Y4R@189775|Thermomicrobia	189775|Thermomicrobia	E	Threonine synthase	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SX1_k127_2461074_1	1244528.CFT03427_1715	3.147e-28	118.0	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,42TSD@68525|delta/epsilon subdivisions,2YPGD@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	endoribonuclease L-PSP	cfiP	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
SX1_k127_2461074_2	935948.KE386494_gene376	6.89e-26	112.0	COG0673@1|root,COG0673@2|Bacteria,1TP83@1239|Firmicutes,248XQ@186801|Clostridia,42EV2@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX1_k127_2466144_0	515635.Dtur_0884	5.88e-211	673.0	COG0556@1|root,COG0556@2|Bacteria	2|Bacteria	L	nucleotide-excision repair	uvrB	GO:0002682,GO:0002684,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006950,GO:0008150,GO:0009314,GO:0009380,GO:0009605,GO:0009607,GO:0009628,GO:0016020,GO:0032991,GO:0035821,GO:0042802,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044424,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03702,ko:K08999	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
SX1_k127_2466144_3	604354.TSIB_0456	1.143e-08	66.0	COG0170@1|root,arCOG01880@2157|Archaea,2XXY5@28890|Euryarchaeota,2439Q@183968|Thermococci	183968|Thermococci	I	PFAM phosphatidate cytidylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_2466144_1	1343739.PAP_09755	5.06e-47	179.0	COG0647@1|root,arCOG04221@2157|Archaea,2XTCH@28890|Euryarchaeota,24345@183968|Thermococci	183968|Thermococci	G	Haloacid dehalogenase-like hydrolase	-	-	3.1.3.41	ko:K01101	ko00627,ko01120,map00627,map01120	-	R03024	RC00151	ko00000,ko00001,ko01000	-	-	-	Hydrolase_6,Hydrolase_like
SX1_k127_2466144_2	1365176.N186_07120	5.466e-17	91.0	COG2120@1|root,arCOG03460@2157|Archaea,2XQXY@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM LmbE family protein	-	-	-	ko:K22408	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
SX1_k127_2467_1	1411685.U062_00646	3.398e-85	299.0	COG1680@1|root,COG1680@2|Bacteria,1MVZN@1224|Proteobacteria,1RP0R@1236|Gammaproteobacteria,1J6V5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SX1_k127_2467_2	1173020.Cha6605_0959	8.847e-39	156.0	COG0508@1|root,COG0508@2|Bacteria,1G4MH@1117|Cyanobacteria	1117|Cyanobacteria	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	-	-	-	-	-	-	-	-	-	-	-	-	2-oxoacid_dh
SX1_k127_2467_0	1121428.DESHY_110486___1	3.47e-104	361.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,263MF@186807|Peptococcaceae	186801|Clostridia	IQ	PFAM AMP-dependent synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
SX1_k127_2495029_3	33898.JRHJ01000049_gene7690	3.471e-26	128.0	COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
SX1_k127_2495029_6	760192.Halhy_0005	8.138e-05	53.0	COG2836@1|root,COG2836@2|Bacteria,4NF84@976|Bacteroidetes,1ISVK@117747|Sphingobacteriia	976|Bacteroidetes	S	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K09792	-	-	-	-	ko00000	-	-	-	DsbD_2
SX1_k127_2495029_4	157072.XP_008870973.1	1.293e-09	68.0	KOG3341@1|root,KOG3341@2759|Eukaryota	2759|Eukaryota	K	protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	SNF8	GO:0000003,GO:0000429,GO:0000430,GO:0000433,GO:0000578,GO:0000741,GO:0000742,GO:0000746,GO:0000747,GO:0000814,GO:0003002,GO:0003006,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005768,GO:0005770,GO:0005829,GO:0005886,GO:0006355,GO:0006357,GO:0006403,GO:0006508,GO:0006511,GO:0006605,GO:0006623,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006862,GO:0006886,GO:0006914,GO:0006996,GO:0006997,GO:0007032,GO:0007034,GO:0007154,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007308,GO:0007309,GO:0007314,GO:0007350,GO:0007351,GO:0007389,GO:0007584,GO:0008022,GO:0008104,GO:0008134,GO:0008150,GO:0008152,GO:0008283,GO:0008298,GO:0008358,GO:0008593,GO:0008595,GO:0009056,GO:0009057,GO:0009605,GO:0009790,GO:0009798,GO:0009880,GO:0009889,GO:0009890,GO:0009892,GO:0009893,GO:0009894,GO:0009896,GO:0009948,GO:0009952,GO:0009966,GO:0009968,GO:0009987,GO:0009991,GO:0009994,GO:0010008,GO:0010256,GO:0010468,GO:0010556,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010646,GO:0010648,GO:0010796,GO:0010797,GO:0010941,GO:0012505,GO:0015031,GO:0015711,GO:0015748,GO:0015833,GO:0015865,GO:0015867,GO:0015868,GO:0015893,GO:0015931,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0016197,GO:0016236,GO:0016247,GO:0016482,GO:0016604,GO:0017157,GO:0019219,GO:0019222,GO:0019538,GO:0019941,GO:0019953,GO:0021700,GO:0022412,GO:0022414,GO:0022607,GO:0023051,GO:0023057,GO:0030154,GO:0030163,GO:0031090,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031410,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0031902,GO:0031974,GO:0031981,GO:0031982,GO:0032456,GO:0032501,GO:0032502,GO:0032504,GO:0032509,GO:0032511,GO:0032535,GO:0032879,GO:0032991,GO:0033036,GO:0033365,GO:0033620,GO:0034613,GO:0035282,GO:0036257,GO:0036258,GO:0036452,GO:0042058,GO:0042059,GO:0042176,GO:0042221,GO:0042493,GO:0042802,GO:0042803,GO:0042886,GO:0042981,GO:0043067,GO:0043162,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043328,GO:0043632,GO:0043900,GO:0043903,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0044703,GO:0044764,GO:0045013,GO:0045014,GO:0045022,GO:0045184,GO:0045324,GO:0045450,GO:0045732,GO:0045892,GO:0045921,GO:0045934,GO:0045990,GO:0046015,GO:0046618,GO:0046907,GO:0046983,GO:0047485,GO:0048284,GO:0048468,GO:0048469,GO:0048471,GO:0048477,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0048599,GO:0048609,GO:0048856,GO:0048869,GO:0050789,GO:0050792,GO:0050794,GO:0050896,GO:0051036,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051171,GO:0051172,GO:0051173,GO:0051179,GO:0051234,GO:0051246,GO:0051247,GO:0051252,GO:0051253,GO:0051503,GO:0051603,GO:0051641,GO:0051649,GO:0051704,GO:0051716,GO:0055037,GO:0060255,GO:0060627,GO:0060810,GO:0060811,GO:0061635,GO:0061919,GO:0061984,GO:0061985,GO:0061986,GO:0061987,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070727,GO:0070887,GO:0070925,GO:0071496,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0071985,GO:0072594,GO:0072665,GO:0072666,GO:0080090,GO:0090066,GO:0097708,GO:0098588,GO:0098772,GO:0098796,GO:0098805,GO:0098927,GO:1901184,GO:1901185,GO:1901264,GO:1901564,GO:1901565,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:1903530,GO:1903532,GO:1903541,GO:1903543,GO:1903772,GO:1903900,GO:1904669,GO:1990904,GO:2000112,GO:2000113,GO:2001141	-	ko:K12188	ko04144,map04144	M00410	-	-	ko00000,ko00001,ko00002,ko04131,ko04147	-	-	-	EAP30
SX1_k127_2495029_5	10090.ENSMUSP00000035918	1.523e-05	56.0	COG1100@1|root,KOG0070@2759|Eukaryota,38MMH@33154|Opisthokonta,3BGDN@33208|Metazoa,3CXVP@33213|Bilateria,4865M@7711|Chordata,48Z18@7742|Vertebrata,3JDGZ@40674|Mammalia,35CI8@314146|Euarchontoglires,4Q4QJ@9989|Rodentia	33208|Metazoa	U	ADP-ribosylation factor-like protein 4D	ARL4D	GO:0002790,GO:0003674,GO:0003824,GO:0003924,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032940,GO:0033036,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K07945	-	-	-	-	ko00000,ko04031	-	-	-	Arf
SX1_k127_2495029_1	1047013.AQSP01000140_gene2469	3.014e-250	779.0	COG2986@1|root,COG2986@2|Bacteria,2NQHF@2323|unclassified Bacteria	2|Bacteria	E	Aromatic amino acid lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
SX1_k127_2495029_0	574087.Acear_1941	9.535e-304	945.0	COG2987@1|root,COG2987@2|Bacteria,1TPZ9@1239|Firmicutes,247YS@186801|Clostridia,3WB0U@53433|Halanaerobiales	186801|Clostridia	H	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
SX1_k127_2495029_2	1121422.AUMW01000005_gene654	2.145e-117	391.0	COG1228@1|root,COG1228@2|Bacteria,1TP2J@1239|Firmicutes,24AGR@186801|Clostridia,260J1@186807|Peptococcaceae	186801|Clostridia	Q	PFAM Amidohydrolase family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
SX1_k127_2501154_0	945713.IALB_3156	3.084e-94	321.0	COG0826@1|root,COG0826@2|Bacteria	2|Bacteria	O	peptidase U32	prtC	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32
SX1_k127_2501154_1	1304880.JAGB01000003_gene1262	1.328e-25	116.0	28KX8@1|root,2ZAD8@2|Bacteria,1U7ZE@1239|Firmicutes,24DFK@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_2510856_1	1292035.H476_2125	1.343e-18	97.0	COG0671@1|root,COG0671@2|Bacteria,1V01Y@1239|Firmicutes,24DFI@186801|Clostridia,25QGY@186804|Peptostreptococcaceae	186801|Clostridia	I	PAP2 superfamily	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
SX1_k127_2510856_0	56780.SYN_02962	6.934e-43	161.0	arCOG05626@1|root,32V4D@2|Bacteria,1NXWW@1224|Proteobacteria,430Y7@68525|delta/epsilon subdivisions,2WVX7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_2510856_2	868131.MSWAN_1244	1.311e-06	56.0	COG0716@1|root,arCOG00519@2157|Archaea,2XZ4A@28890|Euryarchaeota,23PSW@183925|Methanobacteria	183925|Methanobacteria	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_4
SX1_k127_2510856_3	1499967.BAYZ01000137_gene110	1.089e-05	53.0	COG1600@1|root,COG1600@2|Bacteria	2|Bacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Fer4_16
SX1_k127_2515165_1	386456.JQKN01000001_gene2171	6.124e-37	151.0	COG0382@1|root,arCOG00476@2157|Archaea,2XVE4@28890|Euryarchaeota	28890|Euryarchaeota	H	COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	UbiA
SX1_k127_2515165_0	1089553.Tph_c02150	2.129e-117	391.0	COG2006@1|root,COG2006@2|Bacteria,1TRX2@1239|Firmicutes,249GX@186801|Clostridia,42F8W@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Fer4_10,Fer4_7
SX1_k127_2521830_0	323848.Nmul_A1251	1.248e-144	468.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,2VHW5@28216|Betaproteobacteria,372T7@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Alpha-amylase domain	aglA	-	3.2.1.10,3.2.1.20	ko:K01182,ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R01718,R01791,R06087,R06088,R06199	RC00028,RC00049,RC00059,RC00077,RC00451	ko00000,ko00001,ko01000	-	GH13,GH31	-	Alpha-amylase,DUF3459,Malt_amylase_C
SX1_k127_2521830_1	1219084.AP014508_gene1031	7.198e-92	312.0	COG3808@1|root,COG3808@2|Bacteria,2GDSS@200918|Thermotogae	200918|Thermotogae	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	-	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
SX1_k127_2528701_3	304371.MCP_0922	1.398e-14	84.0	COG0433@1|root,arCOG00280@2157|Archaea,2Y7MA@28890|Euryarchaeota,2NA8T@224756|Methanomicrobia	224756|Methanomicrobia	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87,HAS-barrel
SX1_k127_2528701_1	1459636.NTE_02288	6.383e-77	271.0	COG4046@1|root,arCOG04181@2157|Archaea,41S8T@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function (DUF1512)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1512
SX1_k127_2528701_0	374847.Kcr_1078	1.624e-115	389.0	COG0516@1|root,arCOG00612@2157|Archaea	2157|Archaea	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205,1.7.1.7	ko:K00088,ko:K00364	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R01134,R08240	RC00143,RC00457,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
SX1_k127_2528701_2	7227.FBpp0073257	1.682e-25	112.0	KOG0084@1|root,KOG0084@2759|Eukaryota,38DXZ@33154|Opisthokonta,3BEKS@33208|Metazoa,3CWWC@33213|Bilateria,41WJ7@6656|Arthropoda,3SHCS@50557|Insecta,450Y9@7147|Diptera,45Q8B@7214|Drosophilidae	33208|Metazoa	U	GTP binding. It is involved in the biological process described with	-	GO:0003674,GO:0003824,GO:0003924,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005886,GO:0006810,GO:0007154,GO:0007165,GO:0007264,GO:0007265,GO:0008150,GO:0009987,GO:0010008,GO:0012505,GO:0016020,GO:0016192,GO:0016197,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0023052,GO:0031090,GO:0031410,GO:0031982,GO:0032456,GO:0032482,GO:0035556,GO:0043226,GO:0043227,GO:0043229,GO:0044422,GO:0044424,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0046907,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0051716,GO:0065007,GO:0071944,GO:0097708,GO:0098588,GO:0098805	-	ko:K07874	ko05134,map05134	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
SX1_k127_2528701_4	224325.AF_0267	2.462e-06	59.0	arCOG06935@1|root,arCOG06935@2157|Archaea,2Y5IP@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_2534265_1	667014.Thein_0525	3.416e-49	184.0	COG0778@1|root,COG0778@2|Bacteria,2GHT9@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SX1_k127_2534265_2	747365.Thena_1640	2.033e-18	95.0	COG0571@1|root,COG0571@2|Bacteria,1TPGC@1239|Firmicutes,249QD@186801|Clostridia,42FUI@68295|Thermoanaerobacterales	186801|Clostridia	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
SX1_k127_2534265_0	1121413.JMKT01000009_gene1990	2.444e-60	215.0	COG2204@1|root,COG5002@1|root,COG2204@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,43CS7@68525|delta/epsilon subdivisions,2X7ZW@28221|Deltaproteobacteria,2MHC1@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_7,PAS_8,PAS_9,Response_reg,SBP_bac_3,sCache_3_2
SX1_k127_2553539_0	56107.Cylst_1736	7.361e-114	380.0	COG0076@1|root,COG0076@2|Bacteria,1G3F8@1117|Cyanobacteria,1HP30@1161|Nostocales	1117|Cyanobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.15,4.1.1.28,4.1.1.86	ko:K01580,ko:K01593,ko:K13745	ko00250,ko00260,ko00350,ko00360,ko00380,ko00410,ko00430,ko00650,ko00901,ko00950,ko00965,ko01100,ko01110,ko01120,ko02024,ko04726,ko04727,ko04728,ko04940,ko05030,ko05031,ko05034,map00250,map00260,map00350,map00360,map00380,map00410,map00430,map00650,map00901,map00950,map00965,map01100,map01110,map01120,map02024,map04726,map04727,map04728,map04940,map05030,map05031,map05034	M00027,M00037,M00042	R00261,R00489,R00685,R00699,R00736,R01682,R02080,R02466,R02701,R04909,R07650	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
SX1_k127_2569017_0	215803.DB30_3522	1.358e-56	202.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,42M8A@68525|delta/epsilon subdivisions,2WJY0@28221|Deltaproteobacteria,2YUIU@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the SAICAR synthetase family	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
SX1_k127_2569017_3	676032.FN3523_0523	4.518e-12	76.0	COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,1S3QD@1236|Gammaproteobacteria,460YJ@72273|Thiotrichales	72273|Thiotrichales	G	HAD-hyrolase-like	gph	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
SX1_k127_2569017_2	693661.Arcve_0097	2.819e-18	88.0	COG1888@1|root,arCOG04140@2157|Archaea,2Y02A@28890|Euryarchaeota,246DH@183980|Archaeoglobi	183980|Archaeoglobi	S	Uncharacterized ArCR, COG1888	-	-	-	ko:K09732	-	-	-	-	ko00000	-	-	-	DUF211
SX1_k127_2569017_1	251229.Chro_0418	9.019e-24	107.0	COG1100@1|root,COG1100@2|Bacteria,1G5QQ@1117|Cyanobacteria,3VJTG@52604|Pleurocapsales	1117|Cyanobacteria	S	TIGRFAM small GTP-binding protein domain	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Ras
SX1_k127_2569017_4	1459636.NTE_01071	8.248e-06	57.0	COG1378@1|root,arCOG02037@2157|Archaea	2157|Archaea	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
SX1_k127_2569017_5	634498.mru_1760	8.191e-05	48.0	COG2036@1|root,arCOG02144@2157|Archaea	2157|Archaea	K	transcription factor (CBF NF-Y)	hstA	-	-	-	-	-	-	-	-	-	-	-	CBFD_NFYB_HMF
SX1_k127_2572243_3	247490.KSU1_B0431	6.395e-28	119.0	COG1251@1|root,COG1251@2|Bacteria,2IY23@203682|Planctomycetes	203682|Planctomycetes	C	nitrite reductase (NAD(P)H) large subunit	-	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2,Rieske_2
SX1_k127_2572243_1	744872.Spica_0878	4.691e-144	467.0	COG0426@1|root,COG0426@2|Bacteria,2J589@203691|Spirochaetes	203691|Spirochaetes	C	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_5,Lactamase_B
SX1_k127_2572243_4	118005.AWNK01000004_gene1075	7.606e-27	115.0	COG1047@1|root,COG1047@2|Bacteria	2|Bacteria	O	modulation by symbiont of host adenylate cyclase-mediated signal transduction	slyD	-	5.2.1.8	ko:K01802,ko:K03774,ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C,Nitro_FeMo-Co
SX1_k127_2572243_0	177437.HRM2_17530	3.831e-190	603.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2MHKF@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SX1_k127_2572243_5	1410632.JHWW01000015_gene156	2.535e-08	55.0	COG1853@1|root,COG1853@2|Bacteria,1V7DF@1239|Firmicutes,24G44@186801|Clostridia,27IUU@186928|unclassified Lachnospiraceae	186801|Clostridia	C	Flavin reductase like domain	hrb	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct,Rubredoxin
SX1_k127_2572243_2	879212.DespoDRAFT_03042	2.251e-54	195.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42RFX@68525|delta/epsilon subdivisions,2WN92@28221|Deltaproteobacteria,2MJZ5@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
SX1_k127_2580385_11	1209989.TepiRe1_2191	7.278e-08	55.0	COG0561@1|root,COG0561@2|Bacteria,1U3W2@1239|Firmicutes,2486H@186801|Clostridia,42FY8@68295|Thermoanaerobacterales	186801|Clostridia	S	Haloacid dehalogenase domain protein hydrolase, type 3	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
SX1_k127_2580385_8	748727.CLJU_c24920	5.729e-15	83.0	COG0561@1|root,COG0561@2|Bacteria,1UYFN@1239|Firmicutes,249JT@186801|Clostridia,36GUP@31979|Clostridiaceae	186801|Clostridia	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
SX1_k127_2580385_4	159749.K0TEF6	5.284e-39	163.0	COG1100@1|root,KOG0087@2759|Eukaryota,2XEU3@2836|Bacillariophyta	2836|Bacillariophyta	U	Rab subfamily of small GTPases	-	-	-	-	-	-	-	-	-	-	-	-	Ras
SX1_k127_2580385_1	215803.DB30_3758	3.104e-127	425.0	COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,42Q1B@68525|delta/epsilon subdivisions,2WKJH@28221|Deltaproteobacteria,2YU85@29|Myxococcales	28221|Deltaproteobacteria	G	FGGY family of carbohydrate kinases, N-terminal domain	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
SX1_k127_2580385_6	767817.Desgi_2508	8.789e-25	107.0	COG1694@1|root,COG4198@1|root,COG1694@2|Bacteria,COG4198@2|Bacteria,1TQSW@1239|Firmicutes,249E4@186801|Clostridia,2617E@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
SX1_k127_2580385_2	572546.Arcpr_0010	2.504e-114	395.0	COG1328@1|root,COG2074@1|root,arCOG01967@2157|Archaea,arCOG04889@2157|Archaea,2XT2S@28890|Euryarchaeota	28890|Euryarchaeota	F	TIGRFAM anaerobic ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,Intein_splicing,NRDD
SX1_k127_2580385_3	293826.Amet_2171	2.875e-109	372.0	COG0124@1|root,COG0124@2|Bacteria,1TP3D@1239|Firmicutes,24852@186801|Clostridia,36FA9@31979|Clostridiaceae	186801|Clostridia	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
SX1_k127_2580385_10	224719.Abm4_1020	1.873e-08	62.0	COG1308@1|root,arCOG04061@2157|Archaea,2XXYV@28890|Euryarchaeota,23P5R@183925|Methanobacteria	183925|Methanobacteria	K	Contacts the emerging nascent chain on the ribosome	nac	-	-	ko:K03626	-	-	-	-	ko00000	-	-	-	NAC
SX1_k127_2580385_5	589924.Ferp_1022	1.595e-25	112.0	COG1370@1|root,arCOG00991@2157|Archaea,2XYFT@28890|Euryarchaeota,2471G@183980|Archaeoglobi	183980|Archaeoglobi	O	PUA domain containing protein	-	-	-	ko:K07398	-	-	-	-	ko00000	-	-	-	PUA,TGT_C2
SX1_k127_2580385_7	1123274.KB899432_gene2938	3.683e-23	103.0	COG1917@1|root,COG1917@2|Bacteria,2JB5G@203691|Spirochaetes	203691|Spirochaetes	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SX1_k127_2580385_0	224325.AF_1976	2.89e-143	464.0	COG1222@1|root,arCOG01306@2157|Archaea,2XTB6@28890|Euryarchaeota,246U9@183980|Archaeoglobi	183980|Archaeoglobi	O	ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates	pan	-	-	ko:K03420	ko03050,map03050	M00343	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA
SX1_k127_2580385_9	456320.Mvol_1359	5.899e-09	65.0	COG1813@1|root,arCOG01863@2157|Archaea,2XXND@28890|Euryarchaeota,23QX1@183939|Methanococci	183939|Methanococci	K	PFAM helix-turn-helix domain protein	-	-	-	ko:K03627	-	-	-	-	ko00000	-	-	-	HTH_3
SX1_k127_2580385_12	1280686.AUKE01000026_gene574	0.0002458	47.0	COG2262@1|root,COG2262@2|Bacteria,1TNZB@1239|Firmicutes,248IU@186801|Clostridia,4BY8K@830|Butyrivibrio	186801|Clostridia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
SX1_k127_2585603_0	439481.Aboo_1287	1.262e-163	532.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,3F2WH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	TCP-1/cpn60 chaperonin family	thsA	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
SX1_k127_2585603_2	936053.I1C5H6	1.782e-34	145.0	2CXR7@1|root,2RZ71@2759|Eukaryota,3A1VM@33154|Opisthokonta,3P2T8@4751|Fungi,1GRRV@112252|Fungi incertae sedis	4751|Fungi	S	DNA polymerase alpha chain like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_2585603_1	1041930.Mtc_1534	1.95e-56	207.0	COG0202@1|root,arCOG04241@2157|Archaea,2XTQB@28890|Euryarchaeota,2N911@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoD	-	2.7.7.6	ko:K03047	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Fer4,Fer4_9,RNA_pol_A_bac,RNA_pol_L
SX1_k127_2585603_3	572547.Amico_1281	1.164e-05	54.0	COG0598@1|root,COG0598@2|Bacteria,3TARI@508458|Synergistetes	508458|Synergistetes	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
SX1_k127_2599509_0	269797.Mbar_A1408	2.151e-85	297.0	COG3547@1|root,arCOG03585@2157|Archaea,2XWFH@28890|Euryarchaeota	28890|Euryarchaeota	L	COG3547 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
SX1_k127_2599509_1	1433126.BN938_0694	2.573e-11	71.0	COG3547@1|root,COG3547@2|Bacteria,4NJ8G@976|Bacteroidetes,2FRWC@200643|Bacteroidia	976|Bacteroidetes	L	COG COG3547 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
SX1_k127_2613655_3	1304885.AUEY01000011_gene1742	3.812e-65	232.0	COG1180@1|root,COG1180@2|Bacteria,1QJHU@1224|Proteobacteria,42R2E@68525|delta/epsilon subdivisions,2WMYN@28221|Deltaproteobacteria,2MJPF@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
SX1_k127_2613655_0	439235.Dalk_0828	9.746e-267	852.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,42M5J@68525|delta/epsilon subdivisions,2WJAK@28221|Deltaproteobacteria,2MI4X@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM formate C-acetyltransferase glycine radical	-	-	2.3.1.54,4.3.99.4	ko:K00656,ko:K20038	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
SX1_k127_2613655_4	694427.Palpr_0940	1.209e-62	226.0	COG1230@1|root,COG1230@2|Bacteria,4NIHB@976|Bacteroidetes,2FNQ7@200643|Bacteroidia,22W19@171551|Porphyromonadaceae	976|Bacteroidetes	P	Transporter	czcD	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
SX1_k127_2613655_6	1499689.CCNN01000007_gene1134	5.655e-44	169.0	COG4720@1|root,COG4720@2|Bacteria,1V2DR@1239|Firmicutes,249XR@186801|Clostridia,36F8J@31979|Clostridiaceae	186801|Clostridia	S	ECF-type riboflavin transporter, S component	-	-	-	ko:K16927	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.32	-	-	ECF-ribofla_trS,ECF_trnsprt
SX1_k127_2613655_2	485916.Dtox_1967	2.344e-133	444.0	COG0488@1|root,COG0488@2|Bacteria,1UI2R@1239|Firmicutes,25EBF@186801|Clostridia,267CI@186807|Peptococcaceae	186801|Clostridia	S	PFAM ABC transporter related	-	-	-	ko:K16785,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
SX1_k127_2613655_8	485916.Dtox_1966	7.735e-31	133.0	COG0619@1|root,COG0619@2|Bacteria,1TSB5@1239|Firmicutes,24AN7@186801|Clostridia,2616E@186807|Peptococcaceae	186801|Clostridia	P	PFAM Cobalt transport protein	-	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
SX1_k127_2613655_9	330779.Saci_0380	1.929e-12	73.0	COG1489@1|root,arCOG04115@2157|Archaea,2XQFT@28889|Crenarchaeota	28889|Crenarchaeota	S	Sugar fermentation stimulation protein	sfsA	-	-	ko:K06206	-	-	-	-	ko00000	-	-	-	SfsA
SX1_k127_2613655_7	697281.Mahau_2689	5.884e-37	154.0	COG0407@1|root,COG0407@2|Bacteria,1V5JE@1239|Firmicutes,24J5K@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX1_k127_2613655_5	604354.TSIB_0772	1.445e-58	219.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota,243DR@183968|Thermococci	183968|Thermococci	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
SX1_k127_2613655_1	604354.TSIB_0773	3.657e-141	463.0	COG0277@1|root,arCOG00337@2157|Archaea,2XT5C@28890|Euryarchaeota,2430V@183968|Thermococci	183968|Thermococci	C	FAD binding domain	-	-	2.5.1.26	ko:K00803	ko00565,ko01100,ko04146,map00565,map01100,map04146	-	R04311	RC00020,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
SX1_k127_2626920_1	593117.TGAM_1401	9.219e-15	80.0	COG1860@1|root,arCOG04477@2157|Archaea,2XX8X@28890|Euryarchaeota,2449J@183968|Thermococci	183968|Thermococci	S	Belongs to the UPF0179 family	-	-	-	ko:K09730	-	-	-	-	ko00000	-	-	-	UPF0179
SX1_k127_2626920_0	673860.AciM339_1071	2.852e-127	422.0	COG0174@1|root,arCOG01909@2157|Archaea,2XSYS@28890|Euryarchaeota,3F33N@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	TIGRFAM glutamine synthetase, type I	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
SX1_k127_2717052_0	1121904.ARBP01000025_gene6080	6.232e-11	74.0	COG1305@1|root,COG1305@2|Bacteria,4NZRT@976|Bacteroidetes	976|Bacteroidetes	E	7 transmembrane helices usually fused to an inactive transglutaminase	-	-	-	-	-	-	-	-	-	-	-	-	7TM_transglut,Transglut_core
SX1_k127_2722035_0	158190.SpiGrapes_2743	1.062e-65	242.0	COG2211@1|root,COG2211@2|Bacteria,2JAUS@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX1_k127_2722035_1	444158.MmarC6_0894	2.867e-26	114.0	COG2016@1|root,arCOG00985@2157|Archaea,2XX1R@28890|Euryarchaeota,23QZV@183939|Methanococci	183939|Methanococci	J	PFAM PUA domain containing protein	-	GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K07575	-	-	-	-	ko00000	-	-	-	DUF1947,PUA
SX1_k127_273431_0	579137.Metvu_1281	8.887e-74	259.0	COG0533@1|root,arCOG01183@2157|Archaea,arCOG01185@2157|Archaea,2XT07@28890|Euryarchaeota,23Q0H@183939|Methanococci	183939|Methanococci	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function	-	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234,2.7.11.1	ko:K15904	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko01001,ko03016	-	-	-	Kdo,Peptidase_M22,Pkinase,RIO1
SX1_k127_273431_1	439481.Aboo_0280	1.152e-23	113.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,3F34Y@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	Nucleotidyl transferase	graD2	GO:0003674,GO:0003824,GO:0003977,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0070569	2.3.1.157,2.7.7.13,2.7.7.23	ko:K00966,ko:K04042	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00361,M00362	R00416,R00885,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
SX1_k127_274734_0	439481.Aboo_1469	6.25e-206	668.0	COG0495@1|root,arCOG00809@2157|Archaea,2XU7M@28890|Euryarchaeota,3F2EY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0004832,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1g
SX1_k127_274734_1	589924.Ferp_0645	2.543e-47	181.0	COG1810@1|root,arCOG02468@2157|Archaea,2XU42@28890|Euryarchaeota,24608@183980|Archaeoglobi	183980|Archaeoglobi	S	Domain of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	DUF166
SX1_k127_275810_0	272844.PAB0323	6.429e-118	401.0	COG0008@1|root,arCOG04302@2157|Archaea,2XSYV@28890|Euryarchaeota,242MB@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
SX1_k127_275810_2	1236689.MMALV_04050	2.015e-10	69.0	COG4048@1|root,arCOG02103@1|root,arCOG02103@2157|Archaea,arCOG04902@2157|Archaea,2Y0TZ@28890|Euryarchaeota	28890|Euryarchaeota	S	Domain of unknown function (DUF4443)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2111,DUF4443
SX1_k127_275810_1	224719.Abm4_0047	2.3e-29	129.0	COG0441@1|root,arCOG00401@2157|Archaea,2XTFI@28890|Euryarchaeota,23NP6@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-Thr_ED,tRNA-synt_2b
SX1_k127_2763341_2	706587.Desti_4936	1.323e-06	57.0	COG0071@1|root,COG0071@2|Bacteria,1RI2P@1224|Proteobacteria,430UN@68525|delta/epsilon subdivisions,2WVUT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	GvpH
SX1_k127_2763341_0	391625.PPSIR1_17000	4.945e-153	514.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,42KZI@68525|delta/epsilon subdivisions,2WJ2C@28221|Deltaproteobacteria,2YTZK@29|Myxococcales	28221|Deltaproteobacteria	CE	Peptidase family M1 domain	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,HEAT_2,Peptidase_M1
SX1_k127_2763341_1	1122138.AQUZ01000021_gene8518	5.707e-13	81.0	COG1572@1|root,COG3291@1|root,COG1572@2|Bacteria,COG3291@2|Bacteria,2IAZH@201174|Actinobacteria	201174|Actinobacteria	G	Domain of unknown function (DUF4091)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4091,F5_F8_type_C
SX1_k127_2793135_2	391009.Tmel_0795	1.949e-13	71.0	COG4231@1|root,COG4231@2|Bacteria,2GDTR@200918|Thermotogae	200918|Thermotogae	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
SX1_k127_2793135_0	70601.3257174	2.212e-110	372.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,242UT@183968|Thermococci	183968|Thermococci	C	CoA binding domain	-	-	6.2.1.13	ko:K01905	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	CoA_binding_2,Succ_CoA_lig
SX1_k127_2793135_1	391623.TERMP_00724	5.362e-65	233.0	COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,242SN@183968|Thermococci	183968|Thermococci	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
SX1_k127_2800530_2	224325.AF_1199	3.138e-86	293.0	COG1788@1|root,arCOG01987@2157|Archaea,2XVRA@28890|Euryarchaeota,246WP@183980|Archaeoglobi	183980|Archaeoglobi	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
SX1_k127_2800530_3	394221.Mmar10_2849	7.433e-53	196.0	COG1028@1|root,COG1028@2|Bacteria,1MUCH@1224|Proteobacteria,2TQRM@28211|Alphaproteobacteria,43WDR@69657|Hyphomonadaceae	28211|Alphaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	MA20_02360	-	-	-	-	-	-	-	-	-	-	-	adh_short
SX1_k127_2800530_7	1094466.KQS_07425	2.461e-11	70.0	COG2764@1|root,COG2764@2|Bacteria,4NQD7@976|Bacteroidetes,1I2AQ@117743|Flavobacteriia,2NW94@237|Flavobacterium	976|Bacteroidetes	S	Glyoxalase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	3-dmu-9_3-mt
SX1_k127_2800530_1	697303.Thewi_0850	3.877e-126	409.0	COG3246@1|root,COG3246@2|Bacteria,1TQNV@1239|Firmicutes,248TX@186801|Clostridia,42G7H@68295|Thermoanaerobacterales	186801|Clostridia	S	beta-keto acid cleavage enzyme	kce	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
SX1_k127_2800530_0	459349.CLOAM0809	2.388e-159	512.0	COG0001@1|root,COG0001@2|Bacteria,2NNV5@2323|unclassified Bacteria	2|Bacteria	H	PFAM aminotransferase class-III	hemL	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006083,GO:0006091,GO:0006113,GO:0006520,GO:0006553,GO:0006554,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009987,GO:0015980,GO:0016054,GO:0016740,GO:0016769,GO:0016999,GO:0017144,GO:0019475,GO:0019477,GO:0019665,GO:0019666,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0036094,GO:0042737,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0046440,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.6.1.111,5.4.3.8	ko:K01845,ko:K21585	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272,R11607	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SX1_k127_2800530_4	5722.XP_001324521.1	1.623e-41	168.0	COG0476@1|root,KOG2015@2759|Eukaryota	2759|Eukaryota	H	NEDD8 activating enzyme activity	-	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0006464,GO:0006807,GO:0008047,GO:0008144,GO:0008150,GO:0008152,GO:0008641,GO:0009987,GO:0016874,GO:0016877,GO:0016925,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019899,GO:0019948,GO:0030234,GO:0030554,GO:0031510,GO:0031974,GO:0031981,GO:0032182,GO:0032183,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0036211,GO:0043085,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044388,GO:0044390,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0046872,GO:0046982,GO:0046983,GO:0050790,GO:0065007,GO:0065009,GO:0070013,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0098772,GO:1901265,GO:1901363,GO:1901564,GO:1902494	6.2.1.45	ko:K10686	ko04120,map04120	-	-	-	ko00000,ko00001,ko01000,ko04121	-	-	-	E2_bind,ThiF
SX1_k127_2800530_5	7668.SPU_006804-tr	2.515e-15	83.0	COG5078@1|root,KOG0425@2759|Eukaryota,38MXY@33154|Opisthokonta,3BF4C@33208|Metazoa,3CWJ9@33213|Bilateria	33208|Metazoa	O	protein K48-linked ubiquitination	CDC34	GO:0000082,GO:0000209,GO:0000278,GO:0003674,GO:0003824,GO:0004842,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006464,GO:0006508,GO:0006511,GO:0006513,GO:0006725,GO:0006807,GO:0007049,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009966,GO:0009968,GO:0009987,GO:0010033,GO:0010498,GO:0010646,GO:0010648,GO:0010941,GO:0010942,GO:0016567,GO:0016604,GO:0016607,GO:0016740,GO:0019538,GO:0019787,GO:0019899,GO:0019941,GO:0022402,GO:0023051,GO:0023057,GO:0030163,GO:0031625,GO:0031974,GO:0031981,GO:0032446,GO:0034097,GO:0034641,GO:0034645,GO:0035456,GO:0035458,GO:0036211,GO:0042221,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043161,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043523,GO:0043525,GO:0043632,GO:0043949,GO:0043951,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044389,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0044770,GO:0044772,GO:0044843,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051603,GO:0051716,GO:0061630,GO:0061631,GO:0061650,GO:0061659,GO:0065007,GO:0070013,GO:0070647,GO:0070887,GO:0070936,GO:0071310,GO:0071345,GO:0071704,GO:0090083,GO:0090261,GO:0090304,GO:0140096,GO:1901214,GO:1901216,GO:1901360,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1902531,GO:1902532,GO:1903047	2.3.2.23	ko:K02207	ko04120,ko05168,map04120,map05168	-	-	-	ko00000,ko00001,ko01000,ko04121	-	-	-	UQ_con
SX1_k127_2800530_6	28985.XP_453441.1	8.981e-13	78.0	COG1310@1|root,KOG1554@2759|Eukaryota,38D5Q@33154|Opisthokonta,3NUK7@4751|Fungi,3QNEP@4890|Ascomycota,3RTEN@4891|Saccharomycetes,3S0SU@4893|Saccharomycetaceae	4751|Fungi	OT	Catalytic component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes	RRI1	GO:0000003,GO:0000338,GO:0000749,GO:0000754,GO:0000909,GO:0003006,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006464,GO:0006508,GO:0006807,GO:0007275,GO:0008150,GO:0008152,GO:0008180,GO:0008233,GO:0008234,GO:0008237,GO:0009889,GO:0009891,GO:0009893,GO:0009966,GO:0009987,GO:0010033,GO:0010646,GO:0010893,GO:0016787,GO:0019216,GO:0019218,GO:0019222,GO:0019236,GO:0019538,GO:0019783,GO:0019784,GO:0019953,GO:0022414,GO:0023051,GO:0023058,GO:0030447,GO:0030448,GO:0030582,GO:0030584,GO:0031136,GO:0031137,GO:0031139,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032443,GO:0032446,GO:0032501,GO:0032502,GO:0032991,GO:0036211,GO:0040007,GO:0042221,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043900,GO:0043902,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0044703,GO:0045116,GO:0045834,GO:0045940,GO:0046889,GO:0046890,GO:0046999,GO:0048518,GO:0048522,GO:0048583,GO:0048608,GO:0048731,GO:0048856,GO:0050789,GO:0050794,GO:0050810,GO:0050896,GO:0051704,GO:0051716,GO:0061458,GO:0062012,GO:0062013,GO:0065007,GO:0070011,GO:0070452,GO:0070646,GO:0070647,GO:0070791,GO:0070887,GO:0071310,GO:0071444,GO:0071704,GO:0075259,GO:0080090,GO:0106118,GO:0106120,GO:0140096,GO:1901564,GO:1902930,GO:1902932,GO:2000241,GO:2000243	-	ko:K09613	-	-	-	-	ko00000,ko01000,ko01002,ko04121	-	-	-	JAB
SX1_k127_2823438_0	1191523.MROS_2667	6.958e-64	225.0	COG0671@1|root,COG0671@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	LPG_synthase_TM,PAP2
SX1_k127_2823438_1	1191523.MROS_1817	4.684e-61	228.0	2C1MF@1|root,30J6F@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	YjbH
SX1_k127_2823438_3	945550.VISI1226_16623	8.388e-05	55.0	COG5029@1|root,COG5029@2|Bacteria,1QXK7@1224|Proteobacteria,1T3DP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	CarboxypepD_reg-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Prenyltrans
SX1_k127_2823438_2	1123276.KB893257_gene2740	3.158e-06	55.0	291E2@1|root,2ZP0X@2|Bacteria,4P917@976|Bacteroidetes,47WS0@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_283292_1	1348114.OM33_20855	1.937e-05	57.0	COG1520@1|root,COG1520@2|Bacteria,1RB08@1224|Proteobacteria,1S2SZ@1236|Gammaproteobacteria,2Q47M@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
SX1_k127_283292_0	266117.Rxyl_0135	2.863e-36	149.0	COG0596@1|root,COG0596@2|Bacteria,2GNFU@201174|Actinobacteria	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
SX1_k127_2848748_2	1121929.KB898662_gene426	6.091e-24	113.0	COG1409@1|root,COG4632@1|root,COG1409@2|Bacteria,COG4632@2|Bacteria,1TQBV@1239|Firmicutes,4HDPI@91061|Bacilli	91061|Bacilli	G	Phosphodiester glycosidase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,NAGPA,Pur_ac_phosph_N
SX1_k127_2848748_1	1499967.BAYZ01000104_gene3644	8.222e-32	130.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	DUF3795,OsmC
SX1_k127_2848748_0	936053.I1C5H6	1.642e-49	189.0	2CXR7@1|root,2RZ71@2759|Eukaryota,3A1VM@33154|Opisthokonta,3P2T8@4751|Fungi,1GRRV@112252|Fungi incertae sedis	4751|Fungi	S	DNA polymerase alpha chain like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_2848748_3	889378.Spiaf_0647	1.91e-07	61.0	COG1409@1|root,COG1409@2|Bacteria,2J6RQ@203691|Spirochaetes	203691|Spirochaetes	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
SX1_k127_2857901_0	871968.DESME_01885	9.581e-31	138.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1TPG1@1239|Firmicutes,24C2Y@186801|Clostridia,263T4@186807|Peptococcaceae	186801|Clostridia	C	FAD linked oxidases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
SX1_k127_2859532_4	589924.Ferp_1052	3.74e-29	129.0	COG0524@1|root,arCOG00014@2157|Archaea,2XU7Z@28890|Euryarchaeota,245UH@183980|Archaeoglobi	183980|Archaeoglobi	G	Belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
SX1_k127_2859532_0	756499.Desde_3696	4.183e-54	201.0	COG1962@1|root,COG1962@2|Bacteria,1UYYD@1239|Firmicutes,24AC2@186801|Clostridia,2616X@186807|Peptococcaceae	186801|Clostridia	H	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit	-	-	2.1.1.86	ko:K00584	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrH
SX1_k127_2859532_5	693661.Arcve_0397	1.053e-05	55.0	COG4083@1|root,arCOG04471@2157|Archaea,2XTQZ@28890|Euryarchaeota,2464T@183980|Archaeoglobi	183980|Archaeoglobi	S	Transmembrane exosortase (Exosortase_EpsH)	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
SX1_k127_2859532_2	572478.Vdis_0824	6.679e-35	141.0	COG2101@1|root,arCOG01764@2157|Archaea,2XQ5U@28889|Crenarchaeota	28889|Crenarchaeota	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	tbp	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
SX1_k127_2859532_1	342949.PNA2_0649	2.821e-52	203.0	COG1530@1|root,arCOG04307@2157|Archaea,2XUGB@28890|Euryarchaeota,243F3@183968|Thermococci	183968|Thermococci	J	Binds to RNA in loop regions with AU-rich sequences	aubA	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360	-	ko:K22469	-	-	-	-	ko00000,ko03009	-	-	-	DUF402,RNase_E_G
SX1_k127_2859532_3	1347392.CCEZ01000043_gene425	9.855e-31	125.0	COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,24BAN@186801|Clostridia,36F2D@31979|Clostridiaceae	186801|Clostridia	G	overlaps another CDS with the same product name	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
SX1_k127_2877444_5	1220534.B655_0312	2.065e-10	65.0	COG1994@1|root,arCOG00614@2157|Archaea,2XX7B@28890|Euryarchaeota,23P2G@183925|Methanobacteria	183925|Methanobacteria	S	PFAM Peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_2877444_3	565033.GACE_0166	5.863e-18	95.0	COG3582@1|root,arCOG01769@2157|Archaea,2Y894@28890|Euryarchaeota,245UX@183980|Archaeoglobi	183980|Archaeoglobi	S	AN1-like Zinc finger	-	-	-	ko:K07059	-	-	-	-	ko00000	-	-	-	Rhomboid,zf-AN1
SX1_k127_2877444_0	485916.Dtox_1386	6.075e-61	234.0	COG0863@1|root,COG1743@1|root,COG0863@2|Bacteria,COG1743@2|Bacteria,1TQWC@1239|Firmicutes,2492S@186801|Clostridia	186801|Clostridia	L	PFAM DNA methylase N-4 N-6	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
SX1_k127_2877444_1	579137.Metvu_0183	5.25e-57	205.0	COG0378@1|root,arCOG01231@2157|Archaea,2XUJS@28890|Euryarchaeota,23QIT@183939|Methanococci	183939|Methanococci	O	TIGRFAM Hydrogenase accessory protein HypB	-	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
SX1_k127_2877444_4	384616.Pisl_0953	6.975e-14	78.0	COG1958@1|root,arCOG00999@2157|Archaea,2XR1U@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM Like-Sm ribonucleoprotein, core	-	-	-	-	-	-	-	-	-	-	-	-	LSM,Lsm_C,SM-ATX
SX1_k127_2877444_2	926549.KI421517_gene1670	2.916e-55	209.0	COG0153@1|root,COG0153@2|Bacteria,4NFSD@976|Bacteroidetes,47K00@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the GHMP kinase family	-	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
SX1_k127_2902365_3	1121007.AUML01000033_gene2838	0.0001041	53.0	COG4585@1|root,COG4585@2|Bacteria,4NEPS@976|Bacteroidetes,1HYQ1@117743|Flavobacteriia,2YH67@290174|Aquimarina	976|Bacteroidetes	T	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,TPR_10,TPR_12,TPR_7,TPR_8
SX1_k127_2902365_0	292459.STH2928	4.508e-187	615.0	COG2183@1|root,COG2183@2|Bacteria,1TPFE@1239|Firmicutes,248P0@186801|Clostridia	186801|Clostridia	K	Tex-like protein N-terminal domain	yhgF	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
SX1_k127_2902365_2	436308.Nmar_1387	1.66e-05	49.0	COG4919@1|root,arCOG04293@2157|Archaea,41SVI@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Ribosomal protein S30	-	-	-	ko:K02983	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04121	-	-	-	Ribosomal_S30
SX1_k127_2902365_1	224325.AF_0267	2.626e-91	318.0	arCOG06935@1|root,arCOG06935@2157|Archaea,2Y5IP@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_2952625_0	211114.JOEF01000011_gene5186	1.77e-111	370.0	COG4733@1|root,COG4733@2|Bacteria,2I3TX@201174|Actinobacteria,4DYI4@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF2961)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2961
SX1_k127_2952625_1	158190.SpiGrapes_2743	3.283e-69	252.0	COG2211@1|root,COG2211@2|Bacteria,2JAUS@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX1_k127_2952625_2	760011.Spico_1067	1.113e-49	194.0	COG2211@1|root,COG2211@2|Bacteria,2JAUS@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX1_k127_2952871_0	868131.MSWAN_1950	1.052e-124	414.0	COG0595@1|root,arCOG00547@2157|Archaea,2XTIB@28890|Euryarchaeota,23PHA@183925|Methanobacteria	183925|Methanobacteria	J	PFAM RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B_2,RMMBL
SX1_k127_2974389_2	374847.Kcr_1128	1.439e-92	321.0	COG1530@1|root,arCOG00321@2157|Archaea	2157|Archaea	L	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
SX1_k127_2974389_3	1121472.AQWN01000003_gene1462	3.862e-35	150.0	COG0312@1|root,COG0312@2|Bacteria,1TQJ5@1239|Firmicutes,24AGW@186801|Clostridia,260PT@186807|Peptococcaceae	186801|Clostridia	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
SX1_k127_2974389_1	456442.Mboo_1766	4.504e-114	378.0	COG0451@1|root,arCOG01369@2157|Archaea,2XVMJ@28890|Euryarchaeota,2NAHV@224756|Methanomicrobia	224756|Methanomicrobia	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	4.1.1.35,4.2.1.46	ko:K01710,ko:K08678	ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00793	R01384,R06513	RC00402,RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
SX1_k127_2974389_4	5722.XP_001330794.1	1.591e-29	126.0	COG1100@1|root,KOG0086@2759|Eukaryota	2759|Eukaryota	Q	regulation of endocytosis	-	-	-	-	-	-	-	-	-	-	-	-	Ras
SX1_k127_2974389_5	61459.XP_007778371.1	2.239e-20	104.0	KOG3886@1|root,KOG3886@2759|Eukaryota,38EME@33154|Opisthokonta,3NWKP@4751|Fungi,3QPDB@4890|Ascomycota,20CPG@147545|Eurotiomycetes	4751|Fungi	U	Small monomeric GTPase	GTR1	GO:0000166,GO:0000322,GO:0000323,GO:0000324,GO:0000329,GO:0001101,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005764,GO:0005768,GO:0005770,GO:0005773,GO:0005774,GO:0006139,GO:0006325,GO:0006342,GO:0006348,GO:0006351,GO:0006355,GO:0006360,GO:0006383,GO:0006725,GO:0006807,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006995,GO:0006996,GO:0007154,GO:0007165,GO:0007264,GO:0008104,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009267,GO:0009605,GO:0009719,GO:0009889,GO:0009890,GO:0009892,GO:0009894,GO:0009895,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0009991,GO:0010008,GO:0010033,GO:0010243,GO:0010467,GO:0010468,GO:0010506,GO:0010507,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0010646,GO:0010647,GO:0010648,GO:0012505,GO:0015698,GO:0016020,GO:0016043,GO:0016070,GO:0016458,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0018130,GO:0019001,GO:0019219,GO:0019222,GO:0019438,GO:0023051,GO:0023052,GO:0023056,GO:0023057,GO:0031090,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031329,GO:0031330,GO:0031410,GO:0031667,GO:0031668,GO:0031669,GO:0031902,GO:0031982,GO:0032006,GO:0032007,GO:0032008,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032774,GO:0032991,GO:0033036,GO:0033365,GO:0033554,GO:0034448,GO:0034613,GO:0034641,GO:0034645,GO:0034654,GO:0035556,GO:0035639,GO:0036094,GO:0040029,GO:0042221,GO:0042594,GO:0043167,GO:0043168,GO:0043170,GO:0043200,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043562,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044437,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0045814,GO:0045892,GO:0045934,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051179,GO:0051234,GO:0051252,GO:0051253,GO:0051276,GO:0051641,GO:0051716,GO:0060255,GO:0065007,GO:0070727,GO:0070887,GO:0071229,GO:0071230,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0071840,GO:0072657,GO:0072665,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0097708,GO:0098588,GO:0098796,GO:0098805,GO:0098852,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902532,GO:1902533,GO:1902679,GO:1903432,GO:1903506,GO:1903507,GO:1903778,GO:1904262,GO:1904263,GO:1990131,GO:2000112,GO:2000113,GO:2001141	-	ko:K16185	ko04140,ko04150,map04140,map04150	-	-	-	ko00000,ko00001	-	-	-	Gtr1_RagA
SX1_k127_2974389_0	1045858.Bint_0805	1.844e-116	386.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2J5C7@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	Asn_synthase,GATase,GMP_synt_C,NAD_synthase
SX1_k127_2999873_0	269797.Mbar_A0619	8.967e-20	96.0	COG1628@1|root,arCOG00928@2157|Archaea,2XXBV@28890|Euryarchaeota,2N9K3@224756|Methanomicrobia	224756|Methanomicrobia	L	Belongs to the UPF0215 family	-	-	-	ko:K09120	-	-	-	-	ko00000	-	-	-	DUF99
SX1_k127_3045495_3	983920.Y88_2386	2.878e-23	111.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,2JZXX@204457|Sphingomonadales	204457|Sphingomonadales	Q	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
SX1_k127_3045495_0	869210.Marky_1832	4.137e-135	450.0	COG2046@1|root,COG2046@2|Bacteria,1WI8H@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Belongs to the sulfate adenylyltransferase family	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
SX1_k127_3045495_2	869210.Marky_1831	7.433e-65	243.0	COG0529@1|root,COG0529@2|Bacteria,1WK0X@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Catalyzes the synthesis of activated sulfate	cysC	-	2.7.1.25	ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	M00176	R00509,R04928	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase
SX1_k127_3045495_1	755731.Clo1100_2937	1.207e-82	283.0	COG1472@1|root,COG1472@2|Bacteria,1VSFU@1239|Firmicutes,25BFI@186801|Clostridia,36WFE@31979|Clostridiaceae	186801|Clostridia	G	Fibronectin type III-like domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
SX1_k127_3068171_1	880073.Calab_2707	2.598e-74	279.0	COG3852@1|root,COG4191@1|root,COG5002@1|root,COG3852@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,2NS4C@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
SX1_k127_3068171_2	1178540.BA70_03615	6.379e-35	136.0	COG0662@1|root,COG0662@2|Bacteria,1V7K2@1239|Firmicutes,4HN60@91061|Bacilli,1ZR9E@1386|Bacillus	91061|Bacilli	G	3-hydroxyanthranilic acid dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SX1_k127_3068171_0	376686.Fjoh_3389	8.106e-158	520.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,1HX27@117743|Flavobacteriia,2NSF4@237|Flavobacterium	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 3 family	bglB_4	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
SX1_k127_3068171_3	1267535.KB906767_gene3454	1.182e-07	59.0	COG4299@1|root,COG4299@2|Bacteria,3Y3Q4@57723|Acidobacteria	2|Bacteria	S	COGs COG4299 conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624,DUF5009
SX1_k127_3070642_11	218284.CCDN010000001_gene1134	9.238e-07	61.0	COG2120@1|root,COG2120@2|Bacteria,1TV10@1239|Firmicutes,4HFJQ@91061|Bacilli,1ZAZI@1386|Bacillus	91061|Bacilli	S	proteins, LmbE homologs	ypjG	-	-	ko:K01463	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
SX1_k127_3070642_3	1123508.JH636443_gene4957	5.021e-37	157.0	COG3356@1|root,COG3356@2|Bacteria,2IXX5@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Neutral alkaline nonlysosomal ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
SX1_k127_3070642_5	556261.HMPREF0240_01113	3.529e-31	135.0	COG0371@1|root,COG0371@2|Bacteria,1V994@1239|Firmicutes	1239|Firmicutes	C	Iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH_2
SX1_k127_3070642_6	34740.HMEL009752-PA	4.448e-18	97.0	COG0167@1|root,COG1100@1|root,KOG0086@2759|Eukaryota,KOG1436@2759|Eukaryota,38BTB@33154|Opisthokonta,3BDAR@33208|Metazoa,3CRQM@33213|Bilateria,41WZB@6656|Arthropoda,3SID6@50557|Insecta,448GM@7088|Lepidoptera	33208|Metazoa	F	Dihydroorotate dehydrogenase	DHODH	GO:0000003,GO:0000166,GO:0001101,GO:0003674,GO:0003824,GO:0004152,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005758,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006213,GO:0006725,GO:0006807,GO:0006810,GO:0006950,GO:0007275,GO:0007565,GO:0007584,GO:0007589,GO:0007595,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009116,GO:0009163,GO:0009410,GO:0009605,GO:0009987,GO:0009991,GO:0010033,GO:0010181,GO:0010243,GO:0010821,GO:0010941,GO:0010942,GO:0014070,GO:0014074,GO:0016020,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019856,GO:0019866,GO:0022414,GO:0022603,GO:0030879,GO:0031000,GO:0031090,GO:0031667,GO:0031966,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0031981,GO:0032501,GO:0032502,GO:0032553,GO:0033043,GO:0034404,GO:0034641,GO:0034654,GO:0036094,GO:0036270,GO:0036477,GO:0042221,GO:0042493,GO:0042594,GO:0042981,GO:0043025,GO:0043065,GO:0043067,GO:0043068,GO:0043167,GO:0043168,GO:0043200,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043279,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044297,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0044706,GO:0046112,GO:0046134,GO:0046483,GO:0046903,GO:0048037,GO:0048038,GO:0048039,GO:0048513,GO:0048518,GO:0048522,GO:0048731,GO:0048732,GO:0048856,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0050878,GO:0050896,GO:0051128,GO:0051179,GO:0051234,GO:0051704,GO:0055086,GO:0055114,GO:0065007,GO:0065008,GO:0070013,GO:0071704,GO:0072527,GO:0072528,GO:0090140,GO:0097159,GO:0097367,GO:0097458,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:1901698,GO:1901700,GO:1903576	1.3.5.2	ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
SX1_k127_3070642_9	8090.ENSORLP00000002312	2.472e-08	66.0	KOG4423@1|root,KOG4423@2759|Eukaryota,38BWT@33154|Opisthokonta,3B9BE@33208|Metazoa,3CV0Z@33213|Bilateria,47Z5Q@7711|Chordata,498CT@7742|Vertebrata,49YDP@7898|Actinopterygii	33208|Metazoa	U	RAB38c, member of RAS oncogene family	glo-1	GO:0000323,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005764,GO:0005773,GO:0005776,GO:0005794,GO:0005802,GO:0006725,GO:0006726,GO:0006727,GO:0006810,GO:0006856,GO:0006996,GO:0007033,GO:0007040,GO:0007154,GO:0007165,GO:0007264,GO:0007265,GO:0008055,GO:0008057,GO:0008150,GO:0008152,GO:0009058,GO:0009894,GO:0009987,GO:0010506,GO:0010876,GO:0010883,GO:0010941,GO:0012505,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0018130,GO:0019222,GO:0019438,GO:0019748,GO:0019915,GO:0023052,GO:0031090,GO:0031323,GO:0031329,GO:0031410,GO:0031982,GO:0031984,GO:0032438,GO:0032482,GO:0032879,GO:0033036,GO:0033059,GO:0033060,GO:0035556,GO:0042440,GO:0042441,GO:0042470,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043324,GO:0043473,GO:0043474,GO:0044237,GO:0044249,GO:0044422,GO:0044424,GO:0044431,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0044550,GO:0044840,GO:0044841,GO:0046148,GO:0046152,GO:0046158,GO:0046483,GO:0048066,GO:0048069,GO:0048072,GO:0048753,GO:0048770,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0051235,GO:0051716,GO:0065007,GO:0065008,GO:0071704,GO:0071840,GO:0080171,GO:0097708,GO:0098791,GO:1901214,GO:1901360,GO:1901362,GO:1901576,GO:1905952	-	ko:K07918,ko:K07923	-	-	-	-	ko00000,ko04031,ko04131	-	-	-	Ras
SX1_k127_3070642_12	1392488.JHZY01000004_gene2712	2.299e-06	61.0	COG0457@1|root,COG2197@1|root,COG0457@2|Bacteria,COG2197@2|Bacteria,4NGS0@976|Bacteroidetes,1HZ2N@117743|Flavobacteriia,2XK4T@283735|Leeuwenhoekiella	976|Bacteroidetes	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,TPR_12,TPR_7,TPR_8
SX1_k127_3070642_4	224719.Abm4_0827	5.247e-32	139.0	COG3359@1|root,arCOG03130@2157|Archaea,2Y790@28890|Euryarchaeota,23PGT@183925|Methanobacteria	183925|Methanobacteria	L	RNase_H superfamily	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
SX1_k127_3070642_2	697281.Mahau_2772	8.068e-45	178.0	COG0524@1|root,COG0524@2|Bacteria,1V4QY@1239|Firmicutes,24HRA@186801|Clostridia	186801|Clostridia	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
SX1_k127_3070642_0	1384057.CD33_18660	5.38e-96	334.0	COG0578@1|root,COG0578@2|Bacteria,1TQJN@1239|Firmicutes,4HAG8@91061|Bacilli,3IX71@400634|Lysinibacillus	91061|Bacilli	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	glpD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944	1.1.3.21,1.1.5.3	ko:K00105,ko:K00111	ko00564,ko01110,map00564,map01110	-	R00846,R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
SX1_k127_3070642_7	1189612.A33Q_3597	3.116e-16	89.0	COG2518@1|root,COG2518@2|Bacteria,4NFCU@976|Bacteroidetes,47P7V@768503|Cytophagia	976|Bacteroidetes	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
SX1_k127_3070642_10	1408813.AYMG01000008_gene3865	5.358e-07	58.0	COG0526@1|root,COG0526@2|Bacteria,4NQI3@976|Bacteroidetes,1ITTM@117747|Sphingobacteriia	976|Bacteroidetes	CO	thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin,Thioredoxin_9
SX1_k127_3070642_8	28258.KP05_04755	1.794e-09	64.0	COG3255@1|root,COG3255@2|Bacteria,1N206@1224|Proteobacteria,1S8RI@1236|Gammaproteobacteria,1XKS6@135619|Oceanospirillales	135619|Oceanospirillales	I	sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
SX1_k127_3070642_13	908339.HMPREF9265_1477	8.138e-05	53.0	COG0454@1|root,COG0456@2|Bacteria,1V6KU@1239|Firmicutes,4HIKU@91061|Bacilli,3F522@33958|Lactobacillaceae	91061|Bacilli	K	Ribosomal-protein-alanine acetyltransferase	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
SX1_k127_3070642_1	694440.JOMF01000005_gene344	4.836e-89	303.0	COG1180@1|root,arCOG00946@2157|Archaea,2XUB7@28890|Euryarchaeota,2N915@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Radical SAM domain protein	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
SX1_k127_3094732_0	5671.XP_001470003.1	4.214e-21	104.0	COG1100@1|root,KOG0074@2759|Eukaryota,3XXUH@5653|Kinetoplastida	5653|Kinetoplastida	U	Belongs to the small GTPase superfamily. Arf family	ARL-3B	-	-	ko:K07944	-	-	-	-	ko00000,ko03036,ko04031	-	-	-	Arf
SX1_k127_3094732_2	56780.SYN_00362	3.79e-19	98.0	COG0398@1|root,COG0398@2|Bacteria,1RDZ2@1224|Proteobacteria,43AEA@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	SNARE associated Golgi protein	ydjZ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
SX1_k127_3094732_1	521045.Kole_1205	2.969e-19	101.0	COG1906@1|root,COG1906@2|Bacteria,2GCVC@200918|Thermotogae	200918|Thermotogae	S	Protein of unknown function (DUF401)	-	-	-	ko:K09133	-	-	-	-	ko00000	-	-	-	DUF401
SX1_k127_3094732_3	673860.AciM339_1288	2.932e-10	71.0	arCOG02499@1|root,arCOG02499@2157|Archaea,2Y6YI@28890|Euryarchaeota,3F2WY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	NosD
SX1_k127_3094732_4	1380390.JIAT01000010_gene4577	0.0003269	53.0	COG2159@1|root,COG2159@2|Bacteria,2HJ7X@201174|Actinobacteria,4CPK2@84995|Rubrobacteria	84995|Rubrobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
SX1_k127_3119703_0	1131462.DCF50_p850	1.55e-62	219.0	2E55P@1|root,32ZYJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_3119703_2	195250.CM001776_gene3480	3.975e-09	69.0	COG0457@1|root,COG2242@1|root,COG3914@1|root,COG0457@2|Bacteria,COG2242@2|Bacteria,COG3914@2|Bacteria,1G0K6@1117|Cyanobacteria,1H0B3@1129|Synechococcus	1117|Cyanobacteria	O	Glycosyl transferase family 41	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,TPR_11
SX1_k127_3119703_1	1286171.EAL2_808p07490	3.1e-11	66.0	COG3384@1|root,COG3384@2|Bacteria,1TSRZ@1239|Firmicutes,24B3B@186801|Clostridia,25WQU@186806|Eubacteriaceae	186801|Clostridia	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
SX1_k127_31470_2	386456.JQKN01000001_gene1720	2.806e-07	56.0	COG1355@1|root,arCOG01728@2157|Archaea,2XVYU@28890|Euryarchaeota,23P13@183925|Methanobacteria	183925|Methanobacteria	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
SX1_k127_31470_0	6412.HelroP192836	6.848e-38	154.0	COG1161@1|root,KOG2423@2759|Eukaryota,38BQU@33154|Opisthokonta,3B9EG@33208|Metazoa,3CZNX@33213|Bilateria	33208|Metazoa	K	GTP binding	GNL2	GO:0000166,GO:0001654,GO:0001745,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0007275,GO:0007423,GO:0008150,GO:0009653,GO:0009887,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022613,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0042254,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044085,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0048513,GO:0048592,GO:0048731,GO:0048749,GO:0048856,GO:0070013,GO:0071840,GO:0090596,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K14537,ko:K16474	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009,ko03036	-	-	-	MMR_HSR1,NGP1NT
SX1_k127_31470_1	1122985.HMPREF1991_00992	1.03e-14	85.0	COG0524@1|root,COG0524@2|Bacteria,4NFJ9@976|Bacteroidetes,2FM38@200643|Bacteroidia	976|Bacteroidetes	G	Kinase, PfkB family	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
SX1_k127_314816_1	1519464.HY22_08110	2.493e-25	108.0	COG0366@1|root,COG0366@2|Bacteria,1FDG6@1090|Chlorobi	1090|Chlorobi	G	SMART alpha amylase, catalytic sub domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
SX1_k127_314816_0	35841.BT1A1_1870	1.86e-95	321.0	COG0338@1|root,COG0338@2|Bacteria,1TRDX@1239|Firmicutes,4HDFS@91061|Bacilli,1ZAXN@1386|Bacillus	91061|Bacilli	L	D12 class N6 adenine-specific DNA methyltransferase	dpnM	-	2.1.1.72	ko:K06223	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko02048,ko03032,ko03400	-	-	-	MethyltransfD12
SX1_k127_314884_0	1511.CLOST_0463	1.436e-107	361.0	COG1488@1|root,COG1488@2|Bacteria,1TPDW@1239|Firmicutes,247NY@186801|Clostridia,25QM4@186804|Peptostreptococcaceae	186801|Clostridia	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase,QRPTase_C,QRPTase_N
SX1_k127_314884_3	1120965.AUBV01000001_gene3233	1.369e-58	209.0	COG1335@1|root,COG1335@2|Bacteria,4NKPP@976|Bacteroidetes,47XNX@768503|Cytophagia	976|Bacteroidetes	Q	Isochorismatase family	pncA	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
SX1_k127_314884_1	660470.Theba_2271	1.099e-89	308.0	COG0535@1|root,COG0535@2|Bacteria,2GE4B@200918|Thermotogae	200918|Thermotogae	S	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
SX1_k127_314884_2	1226994.AMZB01000123_gene2895	1.239e-72	253.0	COG0596@1|root,COG0596@2|Bacteria,1RDP1@1224|Proteobacteria,1S67D@1236|Gammaproteobacteria,1YDD2@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Serine aminopeptidase, S33	-	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
SX1_k127_314884_4	1033810.HLPCO_001708	6.846e-33	139.0	COG1247@1|root,COG1247@2|Bacteria	2|Bacteria	M	phosphinothricin N-acetyltransferase activity	yhhY	GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234	2.1.2.9	ko:K00604,ko:K03825	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_4
SX1_k127_3161483_1	498761.HM1_2755	1.6e-36	147.0	COG1893@1|root,COG1893@2|Bacteria,1UM1M@1239|Firmicutes,249J4@186801|Clostridia	186801|Clostridia	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	panE	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
SX1_k127_3161483_2	227086.JGI_V11_83143	1.257e-27	121.0	COG1100@1|root,KOG0087@2759|Eukaryota	2759|Eukaryota	J	GTPase activity	RAB11	-	-	ko:K07904,ko:K07905	ko04144,ko04152,ko04961,ko04962,ko04972,map04144,map04152,map04961,map04962,map04972	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
SX1_k127_3161483_3	391623.TERMP_00944	6.05e-15	86.0	COG0704@1|root,arCOG00318@2157|Archaea,2XUA4@28890|Euryarchaeota,243HX@183968|Thermococci	183968|Thermococci	K	SpoVT / AbrB like domain	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
SX1_k127_3161483_0	1094980.Mpsy_1635	3.418e-65	241.0	COG0175@1|root,arCOG02449@1|root,arCOG00073@2157|Archaea,arCOG02449@2157|Archaea,2XUPU@28890|Euryarchaeota,2N9A2@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM PUA domain	-	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0559	Fer4,Fer4_10,PAPS_reduct,PUA
SX1_k127_3162715_1	573063.Metin_1246	0.0003027	54.0	COG0417@1|root,arCOG00328@2157|Archaea,2XU1K@28890|Euryarchaeota,23QQF@183939|Methanococci	183939|Methanococci	L	SMART DNA-directed DNA polymerase B	-	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1,Intein_splicing,LAGLIDADG_3
SX1_k127_3162715_0	1227500.C494_07515	3.625e-50	204.0	COG0417@1|root,COG1372@1|root,arCOG00328@2157|Archaea,arCOG03145@2157|Archaea,2XU1K@28890|Euryarchaeota,23RXE@183963|Halobacteria	183963|Halobacteria	L	COG0417 DNA polymerase elongation subunit (family B)	-	-	-	-	-	-	-	-	-	-	-	-	DNA_pol_B,DNA_pol_B_exo1
SX1_k127_3170863_4	374847.Kcr_0868	8.627e-22	109.0	COG4732@1|root,arCOG04317@2157|Archaea	2157|Archaea	S	Thiamine-precursor transporter protein (ThiW)	-	-	-	-	-	-	-	-	-	-	-	-	ThiW
SX1_k127_3170863_3	667014.Thein_0524	1.187e-24	112.0	COG0351@1|root,COG1992@1|root,COG0351@2|Bacteria,COG1992@2|Bacteria,2GHD1@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	Phosphomethylpyrimidine kinase	-	-	2.5.1.3,2.7.1.49,2.7.4.7	ko:K00941,ko:K21219	ko00730,ko01100,map00730,map01100	M00127	R03223,R03471,R04509,R10712	RC00002,RC00017,RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin,ThiP_synth
SX1_k127_3170863_0	868131.MSWAN_0170	1.682e-144	470.0	COG0422@1|root,arCOG02741@2157|Archaea,2XTMD@28890|Euryarchaeota,23NTD@183925|Methanobacteria	183925|Methanobacteria	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
SX1_k127_3170863_5	589924.Ferp_1733	1.266e-21	100.0	COG1051@1|root,arCOG01075@2157|Archaea,2Y7CI@28890|Euryarchaeota,246AK@183980|Archaeoglobi	183980|Archaeoglobi	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
SX1_k127_3170863_2	1189612.A33Q_3515	7.531e-51	183.0	COG0229@1|root,COG0229@2|Bacteria,4NQEY@976|Bacteroidetes,47PPC@768503|Cytophagia	976|Bacteroidetes	O	Conserved domain frequently associated with peptide methionine sulfoxide reductase	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
SX1_k127_3170863_1	565033.GACE_0238	9.395e-68	239.0	COG0123@1|root,arCOG00327@2157|Archaea,2XV92@28890|Euryarchaeota,245W6@183980|Archaeoglobi	183980|Archaeoglobi	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
SX1_k127_3170863_6	1385512.N784_16175	9.972e-18	85.0	28JAJ@1|root,2Z95C@2|Bacteria,1UBFJ@1239|Firmicutes,4HHFM@91061|Bacilli,2YA14@289201|Pontibacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_3175208_0	227086.JGI_V11_50972	0.0002914	53.0	COG1100@1|root,KOG0071@2759|Eukaryota	2759|Eukaryota	L	Belongs to the small GTPase superfamily. Arf family	ARL15	-	-	ko:K07937,ko:K07941,ko:K17201	ko04014,ko04072,ko04144,ko04666,ko05110,ko05134,map04014,map04072,map04144,map04666,map05110,map05134	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Arf
SX1_k127_3185306_2	1121324.CLIT_13c01000	2.515e-39	168.0	COG1269@1|root,COG1269@2|Bacteria,1TPTE@1239|Firmicutes,249YV@186801|Clostridia	186801|Clostridia	C	Belongs to the V-ATPase 116 kDa subunit family	ntpI	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
SX1_k127_3185306_3	339860.Msp_1133	5.258e-14	80.0	COG1394@1|root,arCOG04101@2157|Archaea,2XTQ5@28890|Euryarchaeota,23NYI@183925|Methanobacteria	183925|Methanobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
SX1_k127_3185306_1	573063.Metin_0451	7.398e-166	533.0	COG1156@1|root,arCOG00865@2157|Archaea,2XSYQ@28890|Euryarchaeota,23Q5U@183939|Methanococci	183939|Methanococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
SX1_k127_3185306_0	941824.TCEL_00594	1.102e-193	621.0	COG1155@1|root,COG1155@2|Bacteria,1TPGS@1239|Firmicutes,24882@186801|Clostridia,36DW7@31979|Clostridiaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
SX1_k127_3185306_4	857293.CAAU_1871	5.472e-09	61.0	COG1436@1|root,COG1436@2|Bacteria,1VEN1@1239|Firmicutes,24K2E@186801|Clostridia,36MRU@31979|Clostridiaceae	186801|Clostridia	C	-ATPase subunit F	-	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
SX1_k127_3185306_6	269797.Mbar_A0388	7.794e-05	54.0	COG1527@1|root,arCOG02459@2157|Archaea,2XTK5@28890|Euryarchaeota,2N9HH@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	iAF692.Mbar_A0388	vATP-synt_AC39
SX1_k127_3185306_7	192952.MM_0784	0.000683	47.0	COG0636@1|root,arCOG02455@2157|Archaea,2XZRP@28890|Euryarchaeota,2N9ZA@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM H transporting two-sector ATPase C subunit	atpK-1	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	iAF692.Mbar_A0390	ATP-synt_C
SX1_k127_3185306_5	1229909.NSED_06110	5.797e-06	56.0	COG1392@1|root,arCOG02640@2157|Archaea,41SGI@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
SX1_k127_3185859_9	1220534.B655_1160	9.377e-19	93.0	COG4635@1|root,arCOG00524@2157|Archaea,2Y1YN@28890|Euryarchaeota	28890|Euryarchaeota	C	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
SX1_k127_3185859_10	1232453.BAIF02000083_gene413	2.8e-07	59.0	COG2020@1|root,COG2020@2|Bacteria,1V495@1239|Firmicutes,24IHG@186801|Clostridia,26B7R@186813|unclassified Clostridiales	186801|Clostridia	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
SX1_k127_3185859_2	1295642.H839_01391	1.999e-67	239.0	COG0384@1|root,COG0384@2|Bacteria,1TPPX@1239|Firmicutes,4HDAC@91061|Bacilli,1WFX3@129337|Geobacillus	91061|Bacilli	S	Phenazine biosynthesis-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
SX1_k127_3185859_6	926550.CLDAP_03620	2.997e-46	176.0	COG0062@1|root,COG0062@2|Bacteria,2G8T6@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX	-	-	5.1.99.6	ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	YjeF_N
SX1_k127_3185859_3	877455.Metbo_1665	3.799e-67	234.0	COG4832@1|root,arCOG03201@2157|Archaea,2Y3NU@28890|Euryarchaeota	28890|Euryarchaeota	S	GyrI-like small molecule binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
SX1_k127_3185859_7	391625.PPSIR1_02216	1.495e-36	145.0	COG1611@1|root,COG1611@2|Bacteria,1RJ91@1224|Proteobacteria,42TR7@68525|delta/epsilon subdivisions,2WQUE@28221|Deltaproteobacteria,2Z1AI@29|Myxococcales	28221|Deltaproteobacteria	S	PFAM conserved	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	DNA_processg_A,Lysine_decarbox
SX1_k127_3185859_1	391009.Tmel_0990	6.407e-92	317.0	COG0174@1|root,COG0174@2|Bacteria,2GC2P@200918|Thermotogae	200918|Thermotogae	H	TIGRFAM glutamine synthetase, type I	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
SX1_k127_3185859_11	5888.CAK74708	6.166e-07	63.0	COG1100@1|root,KOG0098@2759|Eukaryota	2759|Eukaryota	F	GTPase activity	-	-	-	ko:K07877,ko:K07878	ko04152,map04152	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras,Roc
SX1_k127_3185859_4	153721.MYP_3454	6.966e-63	227.0	COG2273@1|root,COG3291@1|root,COG5295@1|root,COG2273@2|Bacteria,COG3291@2|Bacteria,COG5295@2|Bacteria,4NV3D@976|Bacteroidetes,47X3T@768503|Cytophagia	976|Bacteroidetes	G	Glycosyl hydrolases family 16	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_16
SX1_k127_3185859_8	358681.BBR47_10650	5.182e-26	119.0	COG0702@1|root,COG0702@2|Bacteria,1TT3N@1239|Firmicutes,4HB09@91061|Bacilli,26W1M@186822|Paenibacillaceae	91061|Bacilli	GM	NAD(P)H-binding	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	NAD_binding_10
SX1_k127_3185859_0	762982.HMPREF9442_01480	3.229e-138	455.0	COG3408@1|root,COG3408@2|Bacteria,4NI03@976|Bacteroidetes,2FQYR@200643|Bacteroidia	976|Bacteroidetes	G	Glycosyl hydrolase family 63 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
SX1_k127_3185859_5	756499.Desde_2892	7.156e-50	180.0	COG1960@1|root,COG1960@2|Bacteria,1TRR9@1239|Firmicutes,24AJB@186801|Clostridia,260H9@186807|Peptococcaceae	186801|Clostridia	I	PFAM Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SX1_k127_3216400_6	555088.DealDRAFT_1660	1.526e-36	143.0	COG2030@1|root,COG2030@2|Bacteria,1V6MY@1239|Firmicutes,24NB6@186801|Clostridia,42K0A@68298|Syntrophomonadaceae	186801|Clostridia	I	N-terminal half of MaoC dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
SX1_k127_3216400_2	509635.N824_20405	2.504e-90	306.0	COG1621@1|root,COG1621@2|Bacteria,4PNCP@976|Bacteroidetes	976|Bacteroidetes	G	beta-fructofuranosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_3216400_3	644282.Deba_1535	8.203e-70	243.0	COG1545@1|root,COG1545@2|Bacteria	2|Bacteria	I	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
SX1_k127_3216400_0	644282.Deba_1534	6.077e-248	771.0	COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,42N6X@68525|delta/epsilon subdivisions,2WJIE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
SX1_k127_3216400_5	1304880.JAGB01000004_gene1481	1.607e-47	177.0	COG0778@1|root,COG0778@2|Bacteria,1V4ZI@1239|Firmicutes,24BD0@186801|Clostridia	186801|Clostridia	C	nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SX1_k127_3216400_10	195253.Syn6312_0855	3.336e-18	98.0	COG3831@1|root,COG3831@2|Bacteria,1GPKY@1117|Cyanobacteria,1H3GN@1129|Synechococcus	1117|Cyanobacteria	S	Protein of unknown function (DUF4240)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4240
SX1_k127_3216400_1	649747.HMPREF0083_01995	3.908e-92	316.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,4HAWZ@91061|Bacilli,26R1R@186822|Paenibacillaceae	91061|Bacilli	I	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SX1_k127_3216400_9	443254.Marpi_1291	5.189e-23	114.0	COG1409@1|root,COG1409@2|Bacteria,2GDAI@200918|Thermotogae	200918|Thermotogae	P	PFAM Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
SX1_k127_3216400_4	1365176.N186_02405	5.241e-49	182.0	COG2101@1|root,arCOG01764@2157|Archaea,2XQ5U@28889|Crenarchaeota	28889|Crenarchaeota	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	tbp	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
SX1_k127_3216400_11	28229.ND2E_2456	6.756e-06	58.0	COG2311@1|root,COG2311@2|Bacteria,1MWHW@1224|Proteobacteria,1RQ08@1236|Gammaproteobacteria,2Q7U3@267889|Colwelliaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF418)	-	-	-	ko:K07148	-	-	-	-	ko00000	-	-	-	DUF418
SX1_k127_3216400_7	4897.EEB08745	2.035e-36	143.0	COG1100@1|root,KOG0087@2759|Eukaryota,38FAA@33154|Opisthokonta,3NV4U@4751|Fungi,3QNA3@4890|Ascomycota,3MCB9@451866|Taphrinomycotina	4751|Fungi	U	Rab subfamily of small GTPases	YPT31	GO:0000003,GO:0000166,GO:0000212,GO:0000226,GO:0000278,GO:0000281,GO:0000910,GO:0000922,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005628,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0005768,GO:0005794,GO:0005802,GO:0005819,GO:0005856,GO:0005933,GO:0005935,GO:0005938,GO:0006810,GO:0006886,GO:0006887,GO:0006996,GO:0007010,GO:0007017,GO:0007033,GO:0007049,GO:0007051,GO:0007107,GO:0007154,GO:0007165,GO:0007264,GO:0008104,GO:0008150,GO:0009987,GO:0010564,GO:0010720,GO:0012505,GO:0015031,GO:0015630,GO:0015833,GO:0016020,GO:0016043,GO:0016192,GO:0016197,GO:0016462,GO:0016482,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0017157,GO:0019001,GO:0019867,GO:0022402,GO:0022414,GO:0022603,GO:0023052,GO:0030427,GO:0031023,GO:0031090,GO:0031410,GO:0031966,GO:0031967,GO:0031968,GO:0031975,GO:0031982,GO:0031984,GO:0032506,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032879,GO:0032940,GO:0033036,GO:0033365,GO:0034306,GO:0034307,GO:0034498,GO:0034613,GO:0035556,GO:0035639,GO:0036094,GO:0042144,GO:0042147,GO:0042173,GO:0042763,GO:0042764,GO:0042886,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043900,GO:0043902,GO:0043937,GO:0043938,GO:0043940,GO:0043941,GO:0044087,GO:0044089,GO:0044380,GO:0044422,GO:0044424,GO:0044429,GO:0044430,GO:0044431,GO:0044444,GO:0044446,GO:0044448,GO:0044464,GO:0045184,GO:0045595,GO:0045597,GO:0045787,GO:0045881,GO:0045921,GO:0046903,GO:0046907,GO:0048193,GO:0048284,GO:0048518,GO:0048522,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051094,GO:0051128,GO:0051130,GO:0051179,GO:0051234,GO:0051300,GO:0051301,GO:0051321,GO:0051445,GO:0051446,GO:0051641,GO:0051649,GO:0051716,GO:0051726,GO:0055037,GO:0060284,GO:0060627,GO:0061024,GO:0061025,GO:0061640,GO:0061796,GO:0065007,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0071988,GO:0072687,GO:0072697,GO:0072698,GO:0075296,GO:0090068,GO:0090619,GO:0090726,GO:0097159,GO:0097367,GO:0097576,GO:0097708,GO:0098588,GO:0098791,GO:0098805,GO:0099568,GO:1901265,GO:1901363,GO:1902410,GO:1902441,GO:1903023,GO:1903024,GO:1903046,GO:1903047,GO:1903530,GO:1903532,GO:1905508,GO:1990151,GO:1990395,GO:1990778,GO:1990896,GO:2000241,GO:2000243	-	ko:K07904,ko:K07905	ko04144,ko04152,ko04961,ko04962,ko04972,map04144,map04152,map04961,map04962,map04972	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
SX1_k127_3216400_8	1041930.Mtc_2013	1.076e-32	131.0	COG1208@1|root,arCOG00668@2157|Archaea,2Y87G@28890|Euryarchaeota,2N9FU@224756|Methanomicrobia	224756|Methanomicrobia	M	transferase hexapeptide repeat containing protein	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
SX1_k127_3227318_1	1123234.AUKI01000011_gene1284	4.807e-29	120.0	COG1803@1|root,COG1803@2|Bacteria,4NQJ9@976|Bacteroidetes,1I3E4@117743|Flavobacteriia	976|Bacteroidetes	G	methylglyoxal synthase	mgsA	-	4.2.3.3	ko:K01734	ko00640,ko01120,map00640,map01120	-	R01016	RC00424	ko00000,ko00001,ko01000	-	-	-	MGS
SX1_k127_3227318_0	1349822.NSB1T_02890	2.786e-41	173.0	COG2304@1|root,COG2304@2|Bacteria,4P02M@976|Bacteroidetes,2FX22@200643|Bacteroidia	976|Bacteroidetes	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
SX1_k127_3227318_2	1349822.NSB1T_02885	1.073e-24	114.0	COG0714@1|root,COG0714@2|Bacteria,4PAE8@976|Bacteroidetes,2FWQG@200643|Bacteroidia	976|Bacteroidetes	S	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
SX1_k127_3259012_5	1122915.AUGY01000014_gene2679	2.601e-28	127.0	COG2755@1|root,COG2755@2|Bacteria,1VAM0@1239|Firmicutes,4HU6D@91061|Bacilli,26RDP@186822|Paenibacillaceae	91061|Bacilli	E	N-terminus of Esterase_SGNH_hydro-type	-	-	-	-	-	-	-	-	-	-	-	-	GxDLY,Lipase_GDSL_3
SX1_k127_3259012_7	523845.AQXV01000051_gene1218	7.742e-23	111.0	COG1029@1|root,arCOG01499@2157|Archaea,2XTPW@28890|Euryarchaeota,23RJ3@183939|Methanococci	183939|Methanococci	C	Molybdopterin oxidoreductase	-	-	1.2.7.12	ko:K00201	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdopterin
SX1_k127_3259012_6	589924.Ferp_0728	8.235e-24	107.0	COG1145@1|root,arCOG00292@2157|Archaea,2XXJH@28890|Euryarchaeota,2468F@183980|Archaeoglobi	183980|Archaeoglobi	C	formylmethanofuran dehydrogenase, subunit G	-	-	-	ko:K11260	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002	-	-	-	FeS,Fer4
SX1_k127_3259012_4	1094980.Mpsy_2950	6.407e-33	141.0	COG1145@1|root,arCOG02180@2157|Archaea,2XV84@28890|Euryarchaeota,2N9ND@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	fwdF-1	-	-	ko:K00205	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002	-	-	-	Fer4,Fer4_4,Fer4_7
SX1_k127_3259012_3	436114.SYO3AOP1_1113	5.107e-85	293.0	COG0604@1|root,COG0604@2|Bacteria,2G4NX@200783|Aquificae	200783|Aquificae	C	Alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
SX1_k127_3259012_10	1210908.HSB1_00910	7.881e-15	83.0	arCOG05875@1|root,arCOG05876@1|root,arCOG05875@2157|Archaea,arCOG05876@2157|Archaea,2XWFY@28890|Euryarchaeota,23UNU@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	ko:K16906	ko02010,map02010	M00224	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1	-	-	-
SX1_k127_3259012_8	586413.CCDL010000001_gene420	4.247e-17	90.0	COG1668@1|root,COG1668@2|Bacteria,1V2WV@1239|Firmicutes,4HG9R@91061|Bacilli,23KPT@182709|Oceanobacillus	91061|Bacilli	CP	transmembrane transport	-	-	-	ko:K16906	ko02010,map02010	M00224	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
SX1_k127_3259012_1	351160.RCIX1069	2.392e-95	321.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUAX@28890|Euryarchaeota	28890|Euryarchaeota	E	COG1131 ABC-type multidrug transport system ATPase component	-	-	-	ko:K16907	ko02010,map02010	M00224	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1	-	-	ABC_tran
SX1_k127_3259012_11	192952.MM_1257	9.195e-07	60.0	COG1777@1|root,arCOG01684@2157|Archaea,2XUMR@28890|Euryarchaeota,2NA1M@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM regulatory protein, ArsR	-	-	-	ko:K07721	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
SX1_k127_3259012_0	439481.Aboo_0405	1.695e-274	862.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,3F39E@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
SX1_k127_3259012_9	32507.XP_006802449.1	9.869e-17	93.0	COG1100@1|root,KOG0070@2759|Eukaryota,38E6K@33154|Opisthokonta,3BHXW@33208|Metazoa,3CX8Z@33213|Bilateria,48HNF@7711|Chordata,49F8Y@7742|Vertebrata,4A5CR@7898|Actinopterygii	33208|Metazoa	U	ADP-ribosylation factor-like	ARL6	GO:0000166,GO:0001654,GO:0001882,GO:0001883,GO:0003008,GO:0003407,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005874,GO:0005879,GO:0005881,GO:0005886,GO:0005929,GO:0005930,GO:0006464,GO:0006471,GO:0006605,GO:0006612,GO:0006807,GO:0006810,GO:0006886,GO:0006996,GO:0007154,GO:0007165,GO:0007166,GO:0007264,GO:0007265,GO:0007267,GO:0007275,GO:0007368,GO:0007369,GO:0007389,GO:0007399,GO:0007417,GO:0007420,GO:0007423,GO:0007600,GO:0007601,GO:0008104,GO:0008150,GO:0008152,GO:0008289,GO:0008589,GO:0008593,GO:0009653,GO:0009790,GO:0009799,GO:0009855,GO:0009887,GO:0009966,GO:0009987,GO:0010646,GO:0010842,GO:0015031,GO:0015630,GO:0015833,GO:0016020,GO:0016043,GO:0016055,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0022607,GO:0023051,GO:0023052,GO:0030030,GO:0030031,GO:0030117,GO:0030154,GO:0030425,GO:0031090,GO:0031253,GO:0032400,GO:0032401,GO:0032402,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032594,GO:0032838,GO:0032991,GO:0033036,GO:0033059,GO:0033333,GO:0033339,GO:0033365,GO:0034613,GO:0034622,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0036477,GO:0042886,GO:0042995,GO:0043005,GO:0043010,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0043473,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044430,GO:0044441,GO:0044444,GO:0044446,GO:0044447,GO:0044459,GO:0044463,GO:0044464,GO:0044782,GO:0045184,GO:0045444,GO:0046907,GO:0048475,GO:0048513,GO:0048583,GO:0048592,GO:0048593,GO:0048598,GO:0048646,GO:0048731,GO:0048736,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050877,GO:0050896,GO:0050953,GO:0051179,GO:0051234,GO:0051258,GO:0051640,GO:0051641,GO:0051648,GO:0051649,GO:0051650,GO:0051656,GO:0051668,GO:0051716,GO:0051875,GO:0051904,GO:0051905,GO:0060041,GO:0060042,GO:0060170,GO:0060271,GO:0060322,GO:0061024,GO:0061512,GO:0061951,GO:0065003,GO:0065007,GO:0070121,GO:0070727,GO:0070925,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0072659,GO:0090150,GO:0090596,GO:0097014,GO:0097159,GO:0097367,GO:0097447,GO:0097458,GO:0097499,GO:0098588,GO:0098590,GO:0098796,GO:0099080,GO:0099081,GO:0099512,GO:0099513,GO:0099568,GO:0120025,GO:0120031,GO:0120036,GO:0120038,GO:0198738,GO:1901265,GO:1901363,GO:1901564,GO:1903445,GO:1905114,GO:1990778	-	ko:K07951	-	-	-	-	ko00000,ko03036,ko04031,ko04147	-	-	-	Arf
SX1_k127_3259012_2	399550.Smar_0591	9.796e-86	301.0	COG4690@1|root,arCOG03602@2157|Archaea,2XRTU@28889|Crenarchaeota	28889|Crenarchaeota	E	Peptidase family C69	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C69
SX1_k127_3266576_8	177437.HRM2_45120	2.416e-17	85.0	COG1148@1|root,COG1148@2|Bacteria,1N26U@1224|Proteobacteria,43BRX@68525|delta/epsilon subdivisions,2WKFG@28221|Deltaproteobacteria,2MJAN@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
SX1_k127_3266576_7	160799.PBOR_25515	5.175e-27	122.0	COG0329@1|root,COG0329@2|Bacteria,1V10S@1239|Firmicutes,4HGKS@91061|Bacilli,26R9X@186822|Paenibacillaceae	91061|Bacilli	EM	Dihydrodipicolinate synthetase family	-	-	4.1.2.28,4.3.3.7	ko:K01714,ko:K22397	ko00040,ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00040,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R01782,R10147	RC00307,RC00572,RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
SX1_k127_3266576_13	556263.FSEG_00993	4.287e-07	56.0	2E57A@1|root,33A6D@2|Bacteria,37B4U@32066|Fusobacteria	32066|Fusobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_3266576_10	386456.JQKN01000007_gene3312	3.162e-13	79.0	COG1378@1|root,arCOG02037@2157|Archaea,2XYIM@28890|Euryarchaeota	28890|Euryarchaeota	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
SX1_k127_3266576_5	1041930.Mtc_0528	2.891e-49	180.0	COG0041@1|root,arCOG02464@2157|Archaea,2XU0P@28890|Euryarchaeota,2N9SG@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
SX1_k127_3266576_11	591019.Shell_0104	5.988e-12	67.0	COG1552@1|root,arCOG04049@2157|Archaea,2XRHJ@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL40 family	rpl40e	-	-	ko:K02927	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L40e
SX1_k127_3266576_12	1198449.ACAM_0140	5.311e-08	56.0	arCOG04057@1|root,arCOG04057@2157|Archaea,2XSD3@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL38 family	-	-	-	ko:K02923	ko03010,map03010	M00177	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L38e
SX1_k127_3266576_9	930945.SiRe_1838	2.371e-13	77.0	COG0195@1|root,arCOG01761@2157|Archaea,2XQQR@28889|Crenarchaeota	28889|Crenarchaeota	J	Transcription elongation factor	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_3266576_1	697303.Thewi_0291	1.248e-176	566.0	COG1003@1|root,COG1003@2|Bacteria,1TPK9@1239|Firmicutes,2480Q@186801|Clostridia,42FHX@68295|Thermoanaerobacterales	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS11880	Aminotran_5,GDC-P
SX1_k127_3266576_3	1219084.AP014508_gene1087	1.066e-103	353.0	COG0403@1|root,COG0403@2|Bacteria,2GC6V@200918|Thermotogae	200918|Thermotogae	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
SX1_k127_3266576_6	1317122.ATO12_11610	4.971e-35	138.0	COG0509@1|root,COG0509@2|Bacteria,4NQ35@976|Bacteroidetes,1I1X5@117743|Flavobacteriia,2YJJV@290174|Aquimarina	976|Bacteroidetes	E	Glycine cleavage H-protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
SX1_k127_3266576_2	471223.GWCH70_2361	7.932e-107	358.0	COG0404@1|root,COG0404@2|Bacteria,1TRKX@1239|Firmicutes,4H9MX@91061|Bacilli,1WFB5@129337|Geobacillus	91061|Bacilli	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
SX1_k127_3266576_0	342949.PNA2_0538	5.89e-193	616.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,242UA@183968|Thermococci	183968|Thermococci	O	Belongs to the TCP-1 chaperonin family	ths	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
SX1_k127_3266576_4	309799.DICTH_0587	1.455e-66	242.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
SX1_k127_3266576_14	44689.DDB0233879	0.0008962	48.0	KOG4270@1|root,KOG4270@2759|Eukaryota	2759|Eukaryota	S	GTPase activator activity	-	-	-	ko:K20642	-	-	-	-	ko00000,ko04131	-	-	-	PBD,RhoGAP
SX1_k127_3276437_1	195522.BD01_0474	2.055e-27	119.0	COG1890@1|root,arCOG04186@2157|Archaea,2XSX9@28890|Euryarchaeota,242YU@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eS1 family	rps3ae	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576	-	ko:K02984	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S3Ae
SX1_k127_3276437_0	272844.PAB1115	5.175e-86	293.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,242WT@183968|Thermococci	183968|Thermococci	M	Hexapeptide repeat of succinyl-transferase	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
SX1_k127_327701_3	439235.Dalk_3020	3.426e-06	52.0	COG0247@1|root,COG0247@2|Bacteria	2|Bacteria	C	lactate metabolic process	-	-	1.1.5.3	ko:K00113,ko:K21834	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	CCG,DrsE,Fer4_8
SX1_k127_327701_1	439235.Dalk_3020	3.1e-42	171.0	COG0247@1|root,COG0247@2|Bacteria	2|Bacteria	C	lactate metabolic process	-	-	1.1.5.3	ko:K00113,ko:K21834	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	CCG,DrsE,Fer4_8
SX1_k127_327701_2	457570.Nther_2697	7.32e-34	138.0	COG1014@1|root,COG1014@2|Bacteria,1V1DT@1239|Firmicutes,24HIC@186801|Clostridia	186801|Clostridia	C	indolepyruvate ferredoxin oxidoreductase beta subunit	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
SX1_k127_327701_0	1365176.N186_05425	7.789e-104	352.0	COG4231@1|root,arCOG01609@2157|Archaea,2XPN3@28889|Crenarchaeota	28889|Crenarchaeota	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
SX1_k127_3279431_0	563192.HMPREF0179_02149	4.363e-29	131.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,42M5J@68525|delta/epsilon subdivisions,2WJAK@28221|Deltaproteobacteria,2M8NT@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Glycine radical	-	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
SX1_k127_3281705_3	1123239.KB898627_gene3481	1.587e-78	276.0	COG0657@1|root,COG0657@2|Bacteria,1UYX6@1239|Firmicutes,4HEMG@91061|Bacilli	91061|Bacilli	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
SX1_k127_3281705_2	1265505.ATUG01000002_gene1827	1.185e-89	304.0	COG0535@1|root,COG0535@2|Bacteria,1N6IN@1224|Proteobacteria,43BE9@68525|delta/epsilon subdivisions,2X6SR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_3281705_0	415426.Hbut_1581	4.479e-171	547.0	COG5256@1|root,arCOG01561@2157|Archaea,2XPNT@28889|Crenarchaeota	28889|Crenarchaeota	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
SX1_k127_3281705_8	1118054.CAGW01000030_gene800	2.233e-11	76.0	COG1233@1|root,COG1233@2|Bacteria,1UJQC@1239|Firmicutes,4ITCX@91061|Bacilli,277CE@186822|Paenibacillaceae	91061|Bacilli	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
SX1_k127_3281705_7	69014.TK1166	1.208e-14	78.0	arCOG05836@1|root,arCOG05836@2157|Archaea,2Y48U@28890|Euryarchaeota,2444T@183968|Thermococci	183968|Thermococci	S	Ribonuclease III	-	-	-	-	-	-	-	-	-	-	-	-	Ribonucleas_3_2
SX1_k127_3281705_6	1033806.HTIA_1955	4.277e-17	88.0	arCOG14997@1|root,arCOG14997@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_3281705_5	634498.mru_0168	9.624e-23	105.0	COG1096@1|root,arCOG00676@2157|Archaea,2XYYA@28890|Euryarchaeota,23P5F@183925|Methanobacteria	183925|Methanobacteria	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs	csl4	-	-	ko:K07573	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N
SX1_k127_3281705_4	186497.PF0211	4.387e-37	148.0	COG2263@1|root,arCOG00910@2157|Archaea,2XU4P@28890|Euryarchaeota,24393@183968|Thermococci	183968|Thermococci	J	Conserved hypothetical protein 95	-	-	-	ko:K07579	-	-	-	-	ko00000	-	-	-	MTS,PrmA
SX1_k127_3281705_1	243232.MJ_0232	1.703e-142	465.0	COG0148@1|root,arCOG01169@2157|Archaea,2XSXT@28890|Euryarchaeota,23QNJ@183939|Methanococci	183939|Methanococci	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
SX1_k127_3282346_4	44689.DDB0192166	1.77e-09	70.0	2CXR7@1|root,2RZ71@2759|Eukaryota,3XCHC@554915|Amoebozoa	554915|Amoebozoa	S	DNA polymerase alpha chain like domain	-	-	-	-	-	-	-	-	-	-	-	-	PHP
SX1_k127_3282346_2	485913.Krac_3151	3.069e-48	184.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
SX1_k127_3282346_1	1123278.KB893533_gene138	6.341e-57	215.0	COG3693@1|root,COG3693@2|Bacteria,4NE5Z@976|Bacteroidetes,47Q9Y@768503|Cytophagia	976|Bacteroidetes	G	Glycosyl hydrolase family 10	xynT	-	3.2.1.8	ko:K01181	-	-	-	-	ko00000,ko01000	-	-	-	CBM_4_9,Glyco_hydro_10
SX1_k127_3282346_3	647113.Metok_0871	2.361e-31	140.0	COG1229@1|root,arCOG04461@2157|Archaea,2XV5V@28890|Euryarchaeota,23QNZ@183939|Methanococci	183939|Methanococci	C	PFAM Amidohydrolase 3	fwdA	-	1.2.7.12	ko:K00200	ko00680,ko01100,ko01120,ko01130,ko01200,map00680,map01100,map01120,map01130,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_3
SX1_k127_3282346_0	386456.JQKN01000010_gene695	2.391e-160	524.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23NUK@183925|Methanobacteria	183925|Methanobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
SX1_k127_3319001_0	693661.Arcve_1895	1.867e-37	148.0	COG1986@1|root,arCOG01221@2157|Archaea,2XWMP@28890|Euryarchaeota,24715@183980|Archaeoglobi	183980|Archaeoglobi	F	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions	-	GO:0003674,GO:0003824,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111	-	-	-	-	-	-	-	-	-	-	NTPase_I-T
SX1_k127_3319001_1	1229909.NSED_08040	3.02e-06	52.0	COG0525@1|root,arCOG00808@2157|Archaea,41SBK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Anticodon-binding domain of tRNA	-	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
SX1_k127_3322228_2	1174504.AJTN02000206_gene3460	3.21e-15	83.0	COG2030@1|root,COG2030@2|Bacteria,1V7QY@1239|Firmicutes,4HJBV@91061|Bacilli,1ZHJM@1386|Bacillus	91061|Bacilli	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
SX1_k127_3322228_0	1286171.EAL2_808p04300	8.948e-101	339.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1TPE2@1239|Firmicutes,25CRU@186801|Clostridia	186801|Clostridia	P	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SX1_k127_3322228_4	1408473.JHXO01000013_gene611	1.753e-11	70.0	COG3439@1|root,COG3439@2|Bacteria,4NQRI@976|Bacteroidetes	976|Bacteroidetes	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
SX1_k127_3322228_1	479434.Sthe_0455	2.296e-66	237.0	COG2355@1|root,COG2355@2|Bacteria,2G8C9@200795|Chloroflexi,27XYN@189775|Thermomicrobia	189775|Thermomicrobia	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
SX1_k127_3322228_3	8364.ENSXETP00000050171	7.676e-13	80.0	KOG0443@1|root,KOG0443@2759|Eukaryota,38QM1@33154|Opisthokonta,3B9JY@33208|Metazoa,3D0D6@33213|Bilateria,47YVF@7711|Chordata,48X58@7742|Vertebrata	33208|Metazoa	Z	barbed-end actin filament capping	CAPG	GO:0002376,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005814,GO:0005815,GO:0005819,GO:0005856,GO:0006950,GO:0006952,GO:0006955,GO:0008064,GO:0008150,GO:0008290,GO:0009987,GO:0010033,GO:0010639,GO:0015629,GO:0015630,GO:0016043,GO:0019904,GO:0022607,GO:0030030,GO:0030031,GO:0030139,GO:0030496,GO:0030832,GO:0030833,GO:0030834,GO:0030835,GO:0030837,GO:0031333,GO:0031410,GO:0031974,GO:0031981,GO:0031982,GO:0032271,GO:0032272,GO:0032535,GO:0032956,GO:0032970,GO:0032991,GO:0033043,GO:0034097,GO:0034341,GO:0042221,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043242,GO:0043244,GO:0043254,GO:0043933,GO:0044085,GO:0044087,GO:0044422,GO:0044424,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044450,GO:0044464,GO:0044877,GO:0045087,GO:0045335,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051016,GO:0051128,GO:0051129,GO:0051493,GO:0051494,GO:0051693,GO:0051716,GO:0065003,GO:0065007,GO:0065008,GO:0070013,GO:0070887,GO:0071310,GO:0071345,GO:0071346,GO:0071840,GO:0072686,GO:0090066,GO:0090543,GO:0097708,GO:0110053,GO:1901879,GO:1901880,GO:1902903,GO:1902904	-	ko:K10368	-	-	-	-	ko00000,ko04147,ko04812	-	-	-	Gelsolin
SX1_k127_3328137_0	1499967.BAYZ01000068_gene1925	1.234e-17	96.0	COG0407@1|root,COG0407@2|Bacteria	1499967.BAYZ01000068_gene1925|-	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_3328485_0	933801.Ahos_0748	0.0	1092.0	COG0085@1|root,arCOG01762@2157|Archaea,2XPRW@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
SX1_k127_3328485_1	1220534.B655_0455	2.244e-38	154.0	COG0565@1|root,arCOG01018@2157|Archaea,2XUIY@28890|Euryarchaeota,23NM0@183925|Methanobacteria	183925|Methanobacteria	J	TIGRFAM RNA methyltransferase, TrmH	-	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase
SX1_k127_3328485_2	399549.Msed_2279	1.301e-27	120.0	COG1675@1|root,arCOG04270@2157|Archaea,2XR34@28889|Crenarchaeota	28889|Crenarchaeota	K	Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes	tfe	-	-	ko:K03136	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIE_alpha,TF_Zn_Ribbon
SX1_k127_3328485_3	469610.HMPREF0189_01435	1.997e-07	62.0	COG0517@1|root,COG0517@2|Bacteria,1QTXQ@1224|Proteobacteria,2VWDB@28216|Betaproteobacteria,1KPD0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SX1_k127_3339994_14	647113.Metok_1154	1.312e-17	93.0	COG0294@1|root,arCOG01978@2157|Archaea,2XTEW@28890|Euryarchaeota,23QAC@183939|Methanococci	183939|Methanococci	H	PFAM dihydropteroate synthase, DHPS	-	-	-	-	-	-	-	-	-	-	-	-	DUF4346,Pterin_bind
SX1_k127_3339994_6	272844.PAB0368	3.848e-60	216.0	COG0052@1|root,arCOG04245@2157|Archaea,2XTHM@28890|Euryarchaeota,242JS@183968|Thermococci	183968|Thermococci	J	Belongs to the universal ribosomal protein uS2 family	rps2	GO:0000028,GO:0000447,GO:0000460,GO:0000461,GO:0000462,GO:0000466,GO:0000469,GO:0000478,GO:0000479,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0031123,GO:0031125,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043628,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
SX1_k127_3339994_7	523845.AQXV01000052_gene552	3.722e-57	211.0	COG3640@1|root,arCOG00587@2157|Archaea,2XT61@28890|Euryarchaeota,23QPT@183939|Methanococci	183939|Methanococci	D	PFAM Cobyrinic acid a,c-diamide synthase	-	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
SX1_k127_3339994_3	1265505.ATUG01000003_gene324	3.178e-77	272.0	COG2768@1|root,COG2768@2|Bacteria,1R08Q@1224|Proteobacteria,43CRC@68525|delta/epsilon subdivisions,2X7YY@28221|Deltaproteobacteria,2MPKX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
SX1_k127_3339994_1	1094980.Mpsy_2890	1.773e-107	364.0	COG1456@1|root,arCOG01979@2157|Archaea,2XUSG@28890|Euryarchaeota,2N9BD@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing	cdhE	-	2.1.1.245	ko:K00197	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD,FeS
SX1_k127_3339994_2	86416.Clopa_3997	1.605e-89	311.0	COG1621@1|root,COG1621@2|Bacteria,1VRC9@1239|Firmicutes,24XS0@186801|Clostridia,36QY1@31979|Clostridiaceae	186801|Clostridia	G	Glycosyl hydrolases family 32 C terminal	-	-	3.2.1.26	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00801,R00802,R02410,R03635,R03921,R06088	RC00028,RC00077	ko00000,ko00001,ko01000	-	GH32	-	Glyco_hydro_32C,Glyco_hydro_32N
SX1_k127_3339994_9	635013.TherJR_0081	4.204e-32	140.0	COG4927@1|root,COG4927@2|Bacteria,1TQGX@1239|Firmicutes,24AAX@186801|Clostridia,267EA@186807|Peptococcaceae	186801|Clostridia	H	PFAM peptidase C45 acyl-coenzyme A 6-aminopenicillanic acid acyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	AAT
SX1_k127_3339994_10	673860.AciM339_1543	4.194e-30	123.0	COG2007@1|root,arCOG04154@2157|Archaea,2XYXX@28890|Euryarchaeota,3F2SE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Ribosomal protein S8e	rps8e	GO:0000462,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904	-	ko:K02995	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8e
SX1_k127_3339994_13	573064.Mefer_0947	4.112e-22	98.0	COG2174@1|root,arCOG04168@2157|Archaea,2Y0IH@28890|Euryarchaeota,23R6M@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eL34 family	rpl34e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02915	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34e
SX1_k127_3339994_4	330779.Saci_0986	3.672e-77	276.0	COG0644@1|root,arCOG00570@2157|Archaea,2XPWV@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM geranylgeranyl reductase	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2,FAD_binding_3,FAD_oxidored,Trp_halogenase
SX1_k127_3339994_15	1174528.JH992898_gene1391	2.688e-05	55.0	COG0170@1|root,COG0170@2|Bacteria,1G9XA@1117|Cyanobacteria,1JKJ8@1189|Stigonemataceae	1117|Cyanobacteria	I	dolichyl monophosphate biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_3339994_12	273057.SSO0583	1.413e-24	114.0	COG0382@1|root,arCOG00476@2157|Archaea,2XQXW@28889|Crenarchaeota	28889|Crenarchaeota	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids	-	-	2.5.1.42	ko:K17105	ko00564,map00564	-	R04520	RC01171	ko00000,ko00001,ko01000	-	-	-	UbiA
SX1_k127_3339994_5	523850.TON_1065	5.631e-70	245.0	COG1646@1|root,arCOG01085@2157|Archaea,2XTEC@28890|Euryarchaeota,24399@183968|Thermococci	183968|Thermococci	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids	-	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	2.5.1.41	ko:K17104	ko00564,map00564	-	R04158	RC01091	ko00000,ko00001,ko01000	-	-	-	PcrB
SX1_k127_3339994_0	926569.ANT_22400	4.979e-170	556.0	COG3533@1|root,COG3533@2|Bacteria,2G7X9@200795|Chloroflexi	200795|Chloroflexi	S	COGs COG3533 conserved	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Glyco_hydro_127
SX1_k127_3339994_11	946362.XP_004995703.1	1.342e-24	115.0	COG0639@1|root,KOG0374@2759|Eukaryota	2759|Eukaryota	T	phosphoprotein phosphatase activity	BSL1	GO:0003674,GO:0003824,GO:0004721,GO:0004722,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0007623,GO:0008150,GO:0008152,GO:0008287,GO:0009314,GO:0009416,GO:0009605,GO:0009628,GO:0009648,GO:0009649,GO:0009966,GO:0009967,GO:0009987,GO:0010468,GO:0010646,GO:0010647,GO:0016020,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019222,GO:0019538,GO:0019899,GO:0019900,GO:0019901,GO:0023051,GO:0023056,GO:0031974,GO:0031981,GO:0032501,GO:0032879,GO:0032880,GO:0032922,GO:0032991,GO:0036211,GO:0042578,GO:0042752,GO:0043153,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0047485,GO:0048511,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0060255,GO:0065007,GO:0070013,GO:0071704,GO:0071944,GO:0072357,GO:0140096,GO:1900457,GO:1900459,GO:1901564,GO:1902494,GO:1903293	3.1.3.16	ko:K01090,ko:K04460,ko:K14501	ko04010,ko04075,map04010,map04075	-	-	-	ko00000,ko00001,ko01000,ko01009	-	-	-	Kelch_1,Kelch_2,Kelch_3,Kelch_4,Kelch_5,Metallophos,STPPase_N
SX1_k127_3339994_8	1415775.U729_562	2.72e-40	155.0	COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,248D0@186801|Clostridia,36F05@31979|Clostridiaceae	186801|Clostridia	G	M42 glutamyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
SX1_k127_3344236_2	404589.Anae109_2021	4.567e-05	47.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria,2YWBK@29|Myxococcales	28221|Deltaproteobacteria	L	UvrD-like helicase C-terminal domain	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
SX1_k127_3344236_1	526222.Desal_2824	2.099e-54	201.0	COG3359@1|root,COG3359@2|Bacteria,1R6A2@1224|Proteobacteria,42MVN@68525|delta/epsilon subdivisions,2WK0C@28221|Deltaproteobacteria,2M9EZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	RNase_H superfamily	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
SX1_k127_3344236_0	1167006.UWK_01125	5.776e-184	594.0	COG0427@1|root,COG0454@1|root,COG0427@2|Bacteria,COG0456@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria,2MMNB@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Acetyl-CoA hydrolase/transferase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1
SX1_k127_3347940_4	877455.Metbo_0725	4.25e-60	215.0	COG0463@1|root,arCOG01381@2157|Archaea	2157|Archaea	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Glyphos_transf
SX1_k127_3347940_9	273063.STK_02410	6.591e-12	74.0	COG2835@1|root,arCOG04124@2157|Archaea,2XQTG@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Trm112p-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Trm112p
SX1_k127_3347940_6	224719.Abm4_0622	3.703e-40	166.0	COG0472@1|root,arCOG03199@2157|Archaea,2XWCU@28890|Euryarchaeota,23NVP@183925|Methanobacteria	183925|Methanobacteria	M	Glycosyl transferase family 4	-	-	2.7.8.15	ko:K01001	ko00510,ko01100,map00510,map01100	M00055	R05969	RC00002	ko00000,ko00001,ko00002,ko01000,ko01003	-	-	-	Glycos_transf_4
SX1_k127_3347940_3	1068980.ARVW01000001_gene2968	6.663e-85	293.0	COG0458@1|root,COG0458@2|Bacteria	2|Bacteria	F	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	cpsL	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_3,ATPgrasp_Ter
SX1_k127_3347940_2	391623.TERMP_01928	2.367e-93	318.0	COG0399@1|root,arCOG00118@2157|Archaea,2XTRQ@28890|Euryarchaeota,243U2@183968|Thermococci	183968|Thermococci	E	Beta-eliminating lyase	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
SX1_k127_3347940_8	1123261.AXDW01000002_gene1566	3.316e-14	75.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,1X8H5@135614|Xanthomonadales	135614|Xanthomonadales	K	Cold-shock protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
SX1_k127_3347940_10	388413.ALPR1_11945	3.562e-06	59.0	COG2267@1|root,COG2267@2|Bacteria,4PKB6@976|Bacteroidetes,47JMT@768503|Cytophagia	976|Bacteroidetes	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
SX1_k127_3347940_0	1033810.HLPCO_000985	1.39e-176	570.0	COG0520@1|root,COG0520@2|Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	csdA	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
SX1_k127_3347940_7	694429.Pyrfu_0798	9.981e-15	78.0	COG0640@1|root,arCOG01679@2157|Archaea,2XR0G@28889|Crenarchaeota	28889|Crenarchaeota	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
SX1_k127_3347940_1	1469607.KK073768_gene3543	7.95e-144	473.0	COG1640@1|root,COG1640@2|Bacteria,1G0F2@1117|Cyanobacteria,1HJFN@1161|Nostocales	1117|Cyanobacteria	G	TIGRFAM 4-alpha-glucanotransferase	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	iJN678.malQ	Glyco_hydro_77
SX1_k127_3347940_5	573063.Metin_1069	2.269e-45	190.0	COG0419@1|root,arCOG00368@2157|Archaea,2Y7WF@28890|Euryarchaeota,23RVU@183939|Methanococci	183939|Methanococci	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
SX1_k127_3355111_1	572546.Arcpr_0975	6.527e-14	74.0	COG2012@1|root,arCOG04258@2157|Archaea	2157|Archaea	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoH	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03053	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb5_C
SX1_k127_3355111_0	273057.SSO3254	3.444e-76	265.0	COG0085@1|root,arCOG01762@2157|Archaea,2XPRW@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
SX1_k127_3376172_0	760011.Spico_1067	1.23e-67	248.0	COG2211@1|root,COG2211@2|Bacteria,2JAUS@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX1_k127_3377095_0	342949.PNA2_1785	2.839e-137	458.0	COG1855@1|root,arCOG04116@2157|Archaea,2XSZY@28890|Euryarchaeota,242R1@183968|Thermococci	183968|Thermococci	V	K homology RNA-binding domain	-	-	-	ko:K06865	-	-	-	-	ko00000	-	-	-	KH_1,PIN,T2SSE
SX1_k127_3384028_4	1132855.KB913035_gene1694	1.085e-09	70.0	COG2268@1|root,COG2268@2|Bacteria,1P39U@1224|Proteobacteria,2VMEW@28216|Betaproteobacteria	28216|Betaproteobacteria	S	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
SX1_k127_3384028_0	762376.AXYL_03732	3.911e-92	321.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2VNP8@28216|Betaproteobacteria,3T1Y0@506|Alcaligenaceae	28216|Betaproteobacteria	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
SX1_k127_3384028_7	1408422.JHYF01000013_gene558	6.934e-06	53.0	2E12M@1|root,32WIA@2|Bacteria,1VD2B@1239|Firmicutes,24NKB@186801|Clostridia,36M1W@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_3384028_3	386415.NT01CX_1997	2.534e-35	139.0	2E86F@1|root,332JU@2|Bacteria,1UJT8@1239|Firmicutes,24Q1S@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_3384028_5	97138.C820_01889	1.702e-08	63.0	28Q1F@1|root,2ZCJT@2|Bacteria,1VI7R@1239|Firmicutes,24D4W@186801|Clostridia,36EXU@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_3384028_8	1123507.ATVQ01000001_gene1518	1.268e-05	57.0	COG1266@1|root,COG1266@2|Bacteria,2IID1@201174|Actinobacteria,1W9ZD@1268|Micrococcaceae	201174|Actinobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
SX1_k127_3384028_1	926550.CLDAP_28910	3.712e-67	233.0	COG4122@1|root,COG4122@2|Bacteria,2G97D@200795|Chloroflexi	200795|Chloroflexi	S	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24,Methyltransf_3
SX1_k127_3384028_6	1403313.AXBR01000010_gene1034	3.608e-06	58.0	COG1695@1|root,COG1695@2|Bacteria,1VBBY@1239|Firmicutes,4HKRM@91061|Bacilli,1ZHXU@1386|Bacillus	91061|Bacilli	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
SX1_k127_3384028_2	195522.BD01_1939	1.811e-41	166.0	COG2262@1|root,arCOG00353@2157|Archaea,2XT2W@28890|Euryarchaeota,2431W@183968|Thermococci	183968|Thermococci	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0043021,GO:0043022,GO:0044424,GO:0044464,GO:0044877	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
SX1_k127_3386068_1	1384049.CD29_01070	2.013e-05	57.0	COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,4HB1V@91061|Bacilli,3IWNN@400634|Lysinibacillus	91061|Bacilli	EGP	Multidrug transporter	blt	-	-	ko:K08153	-	M00717	-	-	ko00000,ko00002,ko02000	2.A.1.2.8	-	-	MFS_1,MFS_1_like,Sugar_tr
SX1_k127_3386068_0	592029.DDD_2425	8.87e-14	73.0	COG0500@1|root,COG2226@2|Bacteria,4PIF5@976|Bacteroidetes,1I5GT@117743|Flavobacteriia	976|Bacteroidetes	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
SX1_k127_3386978_0	1365176.N186_05055	8.325e-53	195.0	COG0478@1|root,arCOG01181@2157|Archaea,2XPM0@28889|Crenarchaeota	28889|Crenarchaeota	T	RIO-like serine threonine protein kinase fused to N-terminal HTH domain	-	-	2.7.11.1	ko:K07179	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1,Rio2_N
SX1_k127_3386978_1	1056495.Calag_0115	2.118e-18	98.0	COG0477@1|root,arCOG00130@2157|Archaea	2157|Archaea	EGP	Major facilitator superfamily	-	-	-	ko:K08153	-	M00717	-	-	ko00000,ko00002,ko02000	2.A.1.2.8	-	-	MFS_1,PUCC
SX1_k127_3386978_3	126957.SMAR010955-PA	0.0005907	48.0	COG3703@1|root,KOG3182@2759|Eukaryota,39MU2@33154|Opisthokonta,3BG3N@33208|Metazoa,3D1GI@33213|Bilateria,41ZIF@6656|Arthropoda	33208|Metazoa	P	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides	CHAC2	GO:0003674,GO:0003824,GO:0003839,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006751,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0019184,GO:0034641,GO:0042219,GO:0042398,GO:0043043,GO:0043171,GO:0043603,GO:0043604,GO:0044237,GO:0044248,GO:0044249,GO:0044271,GO:0044272,GO:0044273,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051187,GO:0051188,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	-	-	-	-	-	-	-	-	-	-	ChaC
SX1_k127_3386978_2	28583.AMAG_13600T0	1.196e-13	72.0	COG1958@1|root,KOG1783@2759|Eukaryota,3A5NM@33154|Opisthokonta,3P6ZD@4751|Fungi	4751|Fungi	A	Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4 U6 di-snRNP, spliceosomal U4 U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4 U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity)	LSM6	GO:0000375,GO:0000377,GO:0000398,GO:0000932,GO:0003674,GO:0003676,GO:0003723,GO:0003727,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005688,GO:0005730,GO:0005732,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008187,GO:0008266,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0022613,GO:0030490,GO:0030532,GO:0031974,GO:0031981,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0035770,GO:0036464,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044085,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0045292,GO:0046483,GO:0046540,GO:0070013,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097525,GO:0097526,GO:0120114,GO:0120115,GO:1901360,GO:1901363,GO:1990726,GO:1990904	-	ko:K12625	ko03018,ko03040,map03018,map03040	M00354,M00396,M00397	-	-	ko00000,ko00001,ko00002,ko03019,ko03041	-	-	-	LSM
SX1_k127_3395594_0	743722.Sph21_3064	1.441e-49	185.0	COG0500@1|root,COG0500@2|Bacteria,4NGY5@976|Bacteroidetes,1J0S7@117747|Sphingobacteriia	976|Bacteroidetes	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
SX1_k127_3395594_2	675635.Psed_4223	6.961e-13	72.0	COG1733@1|root,COG1733@2|Bacteria,2GMQG@201174|Actinobacteria,4E2UE@85010|Pseudonocardiales	201174|Actinobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,HxlR
SX1_k127_3395594_1	657309.BXY_43780	4.582e-41	162.0	COG0500@1|root,COG2226@2|Bacteria,4NYQF@976|Bacteroidetes,2FMVK@200643|Bacteroidia,4AKJB@815|Bacteroidaceae	976|Bacteroidetes	Q	Nodulation protein S (NodS)	cypM_2	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
SX1_k127_3401150_5	530564.Psta_3184	2.221e-05	51.0	COG3252@1|root,COG3252@2|Bacteria,2IYHJ@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT	mch	-	3.5.4.27	ko:K01499	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03464	RC01870	ko00000,ko00001,ko00002,ko01000	-	-	-	MCH
SX1_k127_3401150_1	192952.MM_1970	2.392e-55	214.0	COG0608@1|root,arCOG00427@2157|Archaea,2XT8Y@28890|Euryarchaeota,2N99F@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM phosphoesterase, RecJ domain protein	recJ	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHHA1
SX1_k127_3401150_2	756272.Plabr_2606	5.324e-44	171.0	COG1606@1|root,COG1606@2|Bacteria,2IXSS@203682|Planctomycetes	203682|Planctomycetes	S	of the PP-loop superfamily	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	Asn_synthase,NAD_synthase
SX1_k127_3401150_3	1265505.ATUG01000002_gene2379	3.55e-17	94.0	COG1148@1|root,COG1148@2|Bacteria,1R0SK@1224|Proteobacteria,43EFN@68525|delta/epsilon subdivisions,2X89E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
SX1_k127_3401150_0	768679.TTX_0949	1.401e-79	282.0	COG1236@1|root,arCOG00541@2157|Archaea,2XPVA@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM beta-lactamase domain protein	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
SX1_k127_3401150_4	436308.Nmar_1401	2.459e-10	62.0	COG0005@1|root,arCOG01327@2157|Archaea,41SDR@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
SX1_k127_3403294_5	644281.MFS40622_0171	6.889e-18	91.0	COG1665@1|root,arCOG01831@2157|Archaea,2XVY6@28890|Euryarchaeota,23QQY@183939|Methanococci	183939|Methanococci	S	PFAM DNA polymerase, beta domain protein region	-	-	-	ko:K09717	-	-	-	-	ko00000	-	-	-	NTP_transf_2
SX1_k127_3403294_2	573064.Mefer_1030	3.145e-55	205.0	COG1469@1|root,arCOG04301@2157|Archaea,2XT11@28890|Euryarchaeota,23QP5@183939|Methanococci	183939|Methanococci	H	Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin	mptA	GO:0003674,GO:0003824,GO:0003933,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044682	3.5.4.39	ko:K17488	ko00790,map00790	-	R10348	RC02504,RC03131	ko00000,ko00001,ko01000	-	-	-	GCHY-1
SX1_k127_3403294_3	387631.Asulf_00103	1.32e-25	113.0	COG1102@1|root,arCOG01037@2157|Archaea,2XWPB@28890|Euryarchaeota,2467H@183980|Archaeoglobi	183980|Archaeoglobi	F	Belongs to the cytidylate kinase family. Type 2 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
SX1_k127_3403294_4	573063.Metin_0112	1.353e-19	91.0	COG2163@1|root,arCOG04167@2157|Archaea,2XYTF@28890|Euryarchaeota,23R4B@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eL14 family	rpl14e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02875	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW
SX1_k127_3403294_0	693661.Arcve_1231	2.113e-111	376.0	COG1973@1|root,arCOG00637@2157|Archaea,2XVGM@28890|Euryarchaeota,245QC@183980|Archaeoglobi	183980|Archaeoglobi	O	AIR synthase related protein domain protein	-	-	-	ko:K07388	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
SX1_k127_3403294_1	386456.JQKN01000002_gene2570	8.754e-75	265.0	COG1907@1|root,arCOG01026@2157|Archaea,2XUFK@28890|Euryarchaeota,23NUV@183925|Methanobacteria	183925|Methanobacteria	S	Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P)	-	-	2.4.2.54	ko:K06984	ko00790,map00790	-	R10337,R11102	-	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
SX1_k127_3409309_1	1178482.BJB45_03525	9.326e-12	71.0	COG0346@1|root,COG0346@2|Bacteria,1N63N@1224|Proteobacteria,1SJ1U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_4
SX1_k127_3409309_0	416591.Tlet_0046	7.499e-39	159.0	COG2211@1|root,COG2211@2|Bacteria,2GDVW@200918|Thermotogae	200918|Thermotogae	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX1_k127_3413523_0	1206732.BAGD01000054_gene1958	2.022e-39	158.0	2C1EG@1|root,2Z7MZ@2|Bacteria,2GK4W@201174|Actinobacteria,4G0H4@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_3413523_4	596327.PORUE0001_0558	2.985e-06	60.0	COG0457@1|root,COG0642@1|root,COG0745@1|root,COG2207@1|root,COG0457@2|Bacteria,COG0745@2|Bacteria,COG2205@2|Bacteria,COG2207@2|Bacteria,4NDXU@976|Bacteroidetes,2FM2N@200643|Bacteroidia,231GI@171551|Porphyromonadaceae	976|Bacteroidetes	T	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,PEPcase,Reg_prop,Response_reg,TPR_12,TPR_7,TPR_8,Y_Y_Y
SX1_k127_3413523_5	1120949.KB903313_gene514	9.051e-06	59.0	COG0846@1|root,COG0846@2|Bacteria	1120949.KB903313_gene514|-	K	NAD+ binding	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_3413523_1	537013.CLOSTMETH_02269	1.597e-21	98.0	COG2314@1|root,COG2314@2|Bacteria,1VNA3@1239|Firmicutes,24UCG@186801|Clostridia,3WMHZ@541000|Ruminococcaceae	186801|Clostridia	S	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	TM2
SX1_k127_3413523_3	56780.SYN_03151	3.705e-10	66.0	COG0426@1|root,COG0426@2|Bacteria	2|Bacteria	C	nitric oxide reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,GGDEF,HATPase_c,Lactamase_B,Response_reg
SX1_k127_3413523_6	1384065.JAGS01000001_gene1062	0.0002087	54.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Cna_B,Cu_amine_oxidN1,PSII_BNR,SLH
SX1_k127_3416304_1	1268072.PSAB_04840	2.771e-57	223.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,4HA4E@91061|Bacilli,26QZ3@186822|Paenibacillaceae	91061|Bacilli	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
SX1_k127_3416304_0	1385514.N782_19840	1.68e-64	228.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,4H9YB@91061|Bacilli,2Y97H@289201|Pontibacillus	91061|Bacilli	E	Belongs to the ABC transporter superfamily	appF	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
SX1_k127_3422050_3	411902.CLOBOL_03661	3.976e-06	53.0	COG1486@1|root,COG1486@2|Bacteria,1TREJ@1239|Firmicutes,25CDW@186801|Clostridia	186801|Clostridia	G	PFAM glycoside hydrolase, family 4	-	-	3.2.1.22	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
SX1_k127_3422050_0	1218108.KB908294_gene2172	6.395e-36	143.0	COG0406@1|root,COG0406@2|Bacteria,4NQD3@976|Bacteroidetes,1I3DF@117743|Flavobacteriia	976|Bacteroidetes	G	phosphoglycerate mutase	cobC	-	3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
SX1_k127_3422050_1	28737.XP_006890428.1	2.372e-22	107.0	COG4886@1|root,KOG0619@2759|Eukaryota,38C0V@33154|Opisthokonta,3BJNH@33208|Metazoa,3CY4A@33213|Bilateria,486GS@7711|Chordata,499UZ@7742|Vertebrata,3JD1K@40674|Mammalia,354XG@311790|Afrotheria	33208|Metazoa	S	Leucine-rich repeat and IQ domain-containing protein 4	LRRIQ4	GO:0003674,GO:0005215,GO:0005216,GO:0005225,GO:0005253,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0007154,GO:0007165,GO:0008150,GO:0008509,GO:0009987,GO:0015075,GO:0015103,GO:0015267,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022803,GO:0022838,GO:0022857,GO:0023052,GO:0031224,GO:0032991,GO:0034220,GO:0034702,GO:0044424,GO:0044425,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0065007,GO:0071944,GO:0098656,GO:0098796,GO:1902495,GO:1990351	-	-	-	-	-	-	-	-	-	-	IQ,LRR_1,LRR_4,LRR_8
SX1_k127_3422050_2	929703.KE386491_gene1372	5.811e-10	60.0	COG1131@1|root,COG1131@2|Bacteria,4NFW9@976|Bacteroidetes,47MY4@768503|Cytophagia	976|Bacteroidetes	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX1_k127_3428352_4	3649.evm.model.supercontig_1042.1	3.563e-07	62.0	COG0693@1|root,KOG2764@2759|Eukaryota,37P4J@33090|Viridiplantae,3GFQW@35493|Streptophyta,3HMR9@3699|Brassicales	35493|Streptophyta	V	DJ-1/PfpI family	-	GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009438,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019172,GO:0019249,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046185,GO:0046394,GO:0051596,GO:0061727,GO:0071704,GO:0072330,GO:1901575,GO:1901576,GO:1901615,GO:1901617	4.2.1.130	ko:K18881	ko00620,ko01120,map00620,map01120	-	R09796	RC02658	ko00000,ko00001,ko01000,ko01002	-	-	-	DJ-1_PfpI
SX1_k127_3428352_3	323259.Mhun_0035	1.99e-08	61.0	COG1970@1|root,arCOG05213@2157|Archaea,2XZ6U@28890|Euryarchaeota,2N9XV@224756|Methanomicrobia	224756|Methanomicrobia	M	Large-conductance mechanosensitive channel, MscL	-	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
SX1_k127_3428352_2	421072.IO89_15410	1.674e-24	111.0	COG3196@1|root,COG3196@2|Bacteria,4NTX4@976|Bacteroidetes,1I85P@117743|Flavobacteriia	976|Bacteroidetes	S	Uncharacterised protein family (UPF0167)	-	-	-	ko:K09925	-	-	-	-	ko00000	-	-	-	UPF0167
SX1_k127_3428352_0	397291.C804_02028	1.652e-69	244.0	COG1533@1|root,COG1533@2|Bacteria,1TRIS@1239|Firmicutes,25CEW@186801|Clostridia,27U4R@186928|unclassified Lachnospiraceae	186801|Clostridia	L	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SX1_k127_3428352_1	192952.MM_0946	2.194e-51	188.0	COG1853@1|root,arCOG02016@2157|Archaea,2XYAJ@28890|Euryarchaeota,2N9RF@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM flavin reductase domain protein, FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
SX1_k127_345509_0	293826.Amet_1912	2.574e-118	387.0	COG3865@1|root,COG3865@2|Bacteria,1TP7B@1239|Firmicutes,24BVW@186801|Clostridia,36GH5@31979|Clostridiaceae	186801|Clostridia	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
SX1_k127_345509_2	204669.Acid345_1930	2.472e-09	69.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3XQ@57723|Acidobacteria,2JKA8@204432|Acidobacteriia	204432|Acidobacteriia	E	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
SX1_k127_345509_1	926569.ANT_22340	2.25e-45	182.0	COG2211@1|root,COG2211@2|Bacteria,2G6RZ@200795|Chloroflexi	200795|Chloroflexi	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX1_k127_3458040_1	351160.LRC72	3.86e-05	51.0	COG4279@1|root,arCOG03431@2157|Archaea,2Y44T@28890|Euryarchaeota	28890|Euryarchaeota	S	SWIM zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
SX1_k127_3458040_0	660470.Theba_2293	1.745e-48	188.0	COG1874@1|root,COG1874@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	BetaGal_dom4_5,Glyco_hydro_2_N,Glyco_hydro_35
SX1_k127_3461061_0	1131462.DCF50_p850	4.203e-43	162.0	2E55P@1|root,32ZYJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_3461061_1	743722.Sph21_4152	2.765e-05	55.0	COG0477@1|root,COG2814@2|Bacteria,4NE09@976|Bacteroidetes,1J0T2@117747|Sphingobacteriia	976|Bacteroidetes	EGP	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family	xylE	-	-	ko:K02100,ko:K03444,ko:K08138	-	-	-	-	ko00000,ko02000	2.A.1.1,2.A.1.1.2,2.A.1.1.3	-	-	Sugar_tr
SX1_k127_3463152_1	931276.Cspa_c30080	7.835e-89	301.0	COG2223@1|root,COG2223@2|Bacteria,1TRS9@1239|Firmicutes,24AFE@186801|Clostridia,36DS2@31979|Clostridiaceae	186801|Clostridia	P	Major Facilitator Superfamily	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
SX1_k127_3463152_0	96561.Dole_2063	1.744e-139	452.0	COG1145@1|root,COG1145@2|Bacteria,1QW1N@1224|Proteobacteria,42YYY@68525|delta/epsilon subdivisions,2WUE0@28221|Deltaproteobacteria,2MN7Z@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
SX1_k127_3463152_2	1443665.JACA01000007_gene203	1.64e-53	198.0	COG0500@1|root,COG2226@2|Bacteria,4PH0U@976|Bacteroidetes,1IHRF@117743|Flavobacteriia,2YIT4@290174|Aquimarina	976|Bacteroidetes	Q	Hypothetical methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
SX1_k127_3468423_13	643473.KB235930_gene3314	7.696e-16	82.0	COG2018@1|root,COG2018@2|Bacteria,1G7A5@1117|Cyanobacteria,1HP7N@1161|Nostocales	1117|Cyanobacteria	S	Roadblock LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
SX1_k127_3468423_16	634498.mru_1128	3.883e-06	61.0	COG0281@1|root,arCOG01331@2157|Archaea,2XTRZ@28890|Euryarchaeota,23PGN@183925|Methanobacteria	183925|Methanobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	EF-hand_5,Peptidase_M48
SX1_k127_3468423_1	411465.PEPMIC_00815	2.126e-86	300.0	COG3199@1|root,COG3199@2|Bacteria,1UAMM@1239|Firmicutes,249JW@186801|Clostridia	186801|Clostridia	S	ATP-NAD kinase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_kinase
SX1_k127_3468423_11	46681.XP_001738222.1	1.925e-22	108.0	COG0468@1|root,KOG1433@2759|Eukaryota,3X8EV@554915|Amoebozoa	554915|Amoebozoa	L	Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA	-	-	-	ko:K04482	ko03440,ko03460,ko05200,ko05212,map03440,map03460,map05200,map05212	-	-	-	ko00000,ko00001,ko03400,ko04121,ko04131	-	-	-	HHH_5,Rad51
SX1_k127_3468423_7	456320.Mvol_0103	2.468e-32	138.0	COG1634@1|root,arCOG04303@2157|Archaea,2XT8R@28890|Euryarchaeota,23Q52@183939|Methanococci	183939|Methanococci	H	Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP)	mptE	-	2.7.6.3	ko:K07142	ko00790,map00790	-	R03503	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	MAF_flag10
SX1_k127_3468423_8	1121456.ATVA01000011_gene1707	2.634e-31	127.0	COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,42RS9@68525|delta/epsilon subdivisions,2WP93@28221|Deltaproteobacteria,2MBW3@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
SX1_k127_3468423_6	484022.Fphi_0399	4.145e-35	141.0	COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,1RN5M@1236|Gammaproteobacteria,460FZ@72273|Thiotrichales	72273|Thiotrichales	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	ftsJ	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
SX1_k127_3468423_2	877455.Metbo_0334	9.699e-71	255.0	COG1867@1|root,arCOG01219@2157|Archaea,2XTUF@28890|Euryarchaeota,23NVN@183925|Methanobacteria	183925|Methanobacteria	J	Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups	trm1	-	2.1.1.215,2.1.1.216	ko:K00555	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TRM
SX1_k127_3468423_12	406327.Mevan_1490	8.875e-20	98.0	COG0468@1|root,arCOG00417@2157|Archaea,2XTI2@28890|Euryarchaeota,23Q38@183939|Methanococci	183939|Methanococci	L	Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange	radB	GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K04484	-	-	-	-	ko00000,ko03400	-	-	-	Rad51
SX1_k127_3468423_15	342949.PNA2_1299	3.008e-11	74.0	arCOG03142@1|root,arCOG03142@2157|Archaea,2XTSE@28890|Euryarchaeota,242JN@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_3468423_14	1121440.AUMA01000016_gene154	1.281e-12	69.0	COG1146@1|root,COG1146@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	MA20_14855	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_7
SX1_k127_3468423_3	457570.Nther_0318	1.346e-60	226.0	COG1146@1|root,COG2006@1|root,COG1146@2|Bacteria,COG2006@2|Bacteria,1TRX2@1239|Firmicutes,249GX@186801|Clostridia	186801|Clostridia	C	binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Fer4_10,Fer4_7
SX1_k127_3468423_4	237368.SCABRO_01409	1.006e-57	217.0	COG2006@1|root,COG2768@1|root,COG2006@2|Bacteria,COG2768@2|Bacteria,2IYV1@203682|Planctomycetes	203682|Planctomycetes	C	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
SX1_k127_3468423_17	1476973.JMMB01000007_gene1852	0.0001347	53.0	COG4194@1|root,COG4194@2|Bacteria,1UY2R@1239|Firmicutes,24BZZ@186801|Clostridia,25T9D@186804|Peptostreptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1648)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1648
SX1_k127_3468423_0	880073.Calab_0273	1.324e-96	334.0	COG2195@1|root,COG2195@2|Bacteria,2NP2Y@2323|unclassified Bacteria	2|Bacteria	E	Peptidase family M20/M25/M40	pepD	-	-	ko:K01270	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
SX1_k127_3468423_10	1395513.P343_00530	3.662e-24	107.0	COG0454@1|root,COG0456@2|Bacteria,1V4GU@1239|Firmicutes,4HKA1@91061|Bacilli	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SX1_k127_3468423_5	2340.JV46_24520	8.521e-48	179.0	COG2020@1|root,COG2020@2|Bacteria,1R7G6@1224|Proteobacteria,1S9RT@1236|Gammaproteobacteria,1JAVK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
SX1_k127_34751_7	368408.Tpen_0080	7.383e-20	96.0	COG1100@1|root,arCOG06769@2157|Archaea	2157|Archaea	S	Ras of Complex, Roc, domain of DAPkinase	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	COR,LRR_4,LRR_8,Roc
SX1_k127_34751_2	1229909.NSED_00570	7.91e-89	304.0	COG0136@1|root,arCOG00494@2157|Archaea,41SFD@651137|Thaumarchaeota	651137|Thaumarchaeota	E	aspartate-semialdehyde dehydrogenase	-	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
SX1_k127_34751_3	525146.Ddes_1942	6.986e-83	285.0	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,42M0X@68525|delta/epsilon subdivisions,2WK4D@28221|Deltaproteobacteria,2M7XK@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
SX1_k127_34751_6	573063.Metin_0713	9.794e-53	196.0	COG0289@1|root,arCOG04393@2157|Archaea,2XTJU@28890|Euryarchaeota,23QE1@183939|Methanococci	183939|Methanococci	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
SX1_k127_34751_1	877455.Metbo_0119	1.95e-107	375.0	COG0019@1|root,arCOG02268@2157|Archaea,2XSY8@28890|Euryarchaeota,23NJI@183925|Methanobacteria	183925|Methanobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
SX1_k127_34751_4	742767.HMPREF9456_01090	6.182e-70	263.0	COG0253@1|root,COG0253@2|Bacteria,4NF26@976|Bacteroidetes,2FNI4@200643|Bacteroidia,22WSU@171551|Porphyromonadaceae	976|Bacteroidetes	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
SX1_k127_34751_5	983544.Lacal_2613	2.275e-58	221.0	COG0460@1|root,COG0527@1|root,COG0460@2|Bacteria,COG0527@2|Bacteria,4NFGR@976|Bacteroidetes,1HX7S@117743|Flavobacteriia	976|Bacteroidetes	E	homoserine dehydrogenase	thrA	-	1.1.1.3,2.7.2.4	ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3
SX1_k127_34751_0	485915.Dret_1351	9.453e-129	419.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42NH6@68525|delta/epsilon subdivisions,2WJCV@28221|Deltaproteobacteria,2M8ZB@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate	dapL	GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
SX1_k127_3493712_2	694429.Pyrfu_0151	3.575e-116	387.0	COG1812@1|root,arCOG01678@2157|Archaea,2XPSB@28889|Crenarchaeota	28889|Crenarchaeota	H	Catalyzes the formation of S-adenosylmethionine from methionine and ATP	mat	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_Synthase
SX1_k127_3493712_1	1499967.BAYZ01000095_gene4220	1.128e-146	475.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	btrR	-	4.2.1.144	ko:K16016	ko01051,ko01130,map01051,map01130	-	R06586,R06595	RC00006,RC00781,RC02678	ko00000,ko00001,ko01000	-	-	-	DegT_DnrJ_EryC1
SX1_k127_3493712_3	3983.cassava4.1_025386m	1.69e-31	136.0	COG1100@1|root,KOG0087@2759|Eukaryota,37J63@33090|Viridiplantae,3GG35@35493|Streptophyta,4JE6B@91835|fabids	35493|Streptophyta	U	Ras-related protein RABA6a-like	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005886,GO:0012505,GO:0016020,GO:0031410,GO:0031982,GO:0043226,GO:0043227,GO:0043229,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097708	-	ko:K07976	-	-	-	-	ko00000,ko04031	-	-	-	Ras
SX1_k127_3493712_0	224325.AF_1722	1.283e-297	952.0	COG1933@1|root,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,246MU@183980|Archaeoglobi	183980|Archaeoglobi	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	PolC_DP2
SX1_k127_3508985_0	5762.XP_002679146.1	6.232e-169	567.0	COG1372@1|root,2QRRC@2759|Eukaryota	2759|Eukaryota	L	reductase	-	GO:0003674,GO:0003824,GO:0004748,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009141,GO:0009142,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	-	-	-	-	-	-	-	-	-	-	Ribonuc_red_lgC
SX1_k127_3508985_1	484019.THA_488	1.157e-93	318.0	COG0182@1|root,COG0182@2|Bacteria,2GCAP@200918|Thermotogae	200918|Thermotogae	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
SX1_k127_3509124_0	351160.LRC202	2.469e-78	272.0	COG2037@1|root,arCOG02695@2157|Archaea,2XT8E@28890|Euryarchaeota,2N97E@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR)	ftr	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.101	ko:K00672	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03390	RC00197,RC00870,RC02881	ko00000,ko00001,ko00002,ko01000	-	-	-	FTR,FTR_C
SX1_k127_3509124_3	5480.G8BJQ6	2.046e-16	90.0	KOG3886@1|root,KOG3886@2759|Eukaryota,38EME@33154|Opisthokonta,3NWKP@4751|Fungi,3QPDB@4890|Ascomycota,3RRBP@4891|Saccharomycetes,47B0N@766764|Debaryomycetaceae	4751|Fungi	U	GTP-binding Protein	GTR1	GO:0000166,GO:0000322,GO:0000323,GO:0000324,GO:0000329,GO:0001101,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005764,GO:0005768,GO:0005770,GO:0005773,GO:0005774,GO:0006139,GO:0006325,GO:0006342,GO:0006348,GO:0006351,GO:0006355,GO:0006360,GO:0006383,GO:0006725,GO:0006807,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006995,GO:0006996,GO:0007154,GO:0007165,GO:0007264,GO:0008104,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009267,GO:0009605,GO:0009719,GO:0009889,GO:0009890,GO:0009892,GO:0009894,GO:0009895,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0009991,GO:0010008,GO:0010033,GO:0010243,GO:0010467,GO:0010468,GO:0010506,GO:0010507,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0010646,GO:0010647,GO:0010648,GO:0012505,GO:0015698,GO:0016020,GO:0016043,GO:0016070,GO:0016458,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0018130,GO:0019001,GO:0019219,GO:0019222,GO:0019438,GO:0023051,GO:0023052,GO:0023056,GO:0023057,GO:0031090,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031329,GO:0031330,GO:0031410,GO:0031667,GO:0031668,GO:0031669,GO:0031902,GO:0031982,GO:0032006,GO:0032007,GO:0032008,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032774,GO:0032991,GO:0033036,GO:0033365,GO:0033554,GO:0034448,GO:0034613,GO:0034641,GO:0034645,GO:0034654,GO:0035556,GO:0035639,GO:0036094,GO:0040029,GO:0042221,GO:0042594,GO:0043167,GO:0043168,GO:0043170,GO:0043200,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043562,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044437,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0045814,GO:0045892,GO:0045934,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051179,GO:0051234,GO:0051252,GO:0051253,GO:0051276,GO:0051641,GO:0051716,GO:0060255,GO:0065007,GO:0070727,GO:0070887,GO:0071229,GO:0071230,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0071840,GO:0072657,GO:0072665,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0097708,GO:0098588,GO:0098796,GO:0098805,GO:0098852,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902532,GO:1902533,GO:1902679,GO:1903432,GO:1903506,GO:1903507,GO:1903778,GO:1904262,GO:1904263,GO:1990131,GO:2000112,GO:2000113,GO:2001141	-	ko:K16185	ko04140,ko04150,map04140,map04150	-	-	-	ko00000,ko00001	-	-	-	Gtr1_RagA
SX1_k127_3509124_2	1519464.HY22_02620	8.475e-60	211.0	COG0503@1|root,COG0503@2|Bacteria,1FE1Q@1090|Chlorobi	1090|Chlorobi	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
SX1_k127_3509124_1	453591.Igni_1103	1.08e-77	267.0	COG0005@1|root,arCOG01327@2157|Archaea,2XPU0@28889|Crenarchaeota	28889|Crenarchaeota	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
SX1_k127_3509946_1	1238450.VIBNISOn1_1070053	2.65e-17	95.0	COG1752@1|root,COG1752@2|Bacteria,1PWKF@1224|Proteobacteria,1TIQ9@1236|Gammaproteobacteria,1XZG6@135623|Vibrionales	135623|Vibrionales	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
SX1_k127_3509946_0	247633.GP2143_14561	7.524e-62	223.0	COG2211@1|root,COG2211@2|Bacteria	2|Bacteria	G	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX1_k127_3517106_3	246969.TAM4_1107	8.932e-39	156.0	COG1014@1|root,arCOG01603@2157|Archaea,2XVFR@28890|Euryarchaeota,243DZ@183968|Thermococci	183968|Thermococci	C	pyruvate synthase activity	porG	-	1.2.7.1,1.2.7.7	ko:K00172,ko:K00189	ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R07160,R08034,R08566,R08567	RC00004,RC00250,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
SX1_k127_3517106_9	521045.Kole_0380	1.494e-13	81.0	COG1144@1|root,COG1144@2|Bacteria,2GD79@200918|Thermotogae	200918|Thermotogae	C	TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit	-	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
SX1_k127_3517106_0	573063.Metin_1339	6.341e-63	231.0	COG0674@1|root,arCOG01608@2157|Archaea,2XTB0@28890|Euryarchaeota,23QBD@183939|Methanococci	183939|Methanococci	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	porA	GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016491,GO:0050896,GO:0055114	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
SX1_k127_3517106_5	426368.MmarC7_0748	9.991e-31	134.0	COG1013@1|root,arCOG01601@2157|Archaea,2XT3E@28890|Euryarchaeota,23Q2N@183939|Methanococci	183939|Methanococci	C	PFAM thiamine pyrophosphate protein domain protein TPP-binding	porB	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
SX1_k127_3517106_8	1163745.HCD_08015	1.535e-14	85.0	COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,42MQY@68525|delta/epsilon subdivisions,2YMWJ@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	pyruvate ferredoxin oxidoreductase	porB	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
SX1_k127_3517106_1	456320.Mvol_0879	7.917e-46	174.0	COG1011@1|root,arCOG02291@2157|Archaea,2XTX3@28890|Euryarchaeota,23QPZ@183939|Methanococci	183939|Methanococci	S	HAD-superfamily hydrolase, subfamily IA, variant 1	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
SX1_k127_3517106_6	1131266.ARWQ01000002_gene497	8.426e-26	109.0	COG0760@1|root,arCOG07441@2157|Archaea,41SSK@651137|Thaumarchaeota	651137|Thaumarchaeota	O	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3
SX1_k127_3517106_7	436308.Nmar_0650	8.969e-26	117.0	COG0388@1|root,arCOG00062@2157|Archaea	2157|Archaea	H	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.3	ko:K13566	ko00250,map00250	-	R00269,R00348	RC00010	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
SX1_k127_3517106_2	453591.Igni_0043	1.375e-42	160.0	COG1781@1|root,arCOG04229@2157|Archaea,2XQJR@28889|Crenarchaeota	28889|Crenarchaeota	F	Involved in allosteric regulation of aspartate carbamoyltransferase	pyrI	-	-	ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002	-	-	-	PyrI,PyrI_C
SX1_k127_3517106_4	647113.Metok_1390	7.407e-37	151.0	COG2520@1|root,arCOG00033@2157|Archaea,2XTSI@28890|Euryarchaeota,23Q37@183939|Methanococci	183939|Methanococci	J	RNA cap guanine-N2 methyltransferase	-	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
SX1_k127_3520092_1	243232.MJ_1038	1.443e-60	218.0	COG0159@1|root,arCOG01086@2157|Archaea,2XTAW@28890|Euryarchaeota,23QRY@183939|Methanococci	183939|Methanococci	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
SX1_k127_3520092_0	1347086.CCBA010000031_gene939	2.457e-115	377.0	COG0133@1|root,COG0133@2|Bacteria,1TPI3@1239|Firmicutes,4H9WC@91061|Bacilli,1ZCBT@1386|Bacillus	91061|Bacilli	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20,5.3.1.24	ko:K01696,ko:K01817	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722,R03509	RC00209,RC00210,RC00700,RC00701,RC00945,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU22640	PALP
SX1_k127_352207_0	180332.JTGN01000011_gene442	2.605e-261	825.0	COG3408@1|root,COG3408@2|Bacteria,1TPY5@1239|Firmicutes,249U8@186801|Clostridia	186801|Clostridia	G	Alpha-L-rhamnosidase N-terminal domain protein	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
SX1_k127_352207_1	1140002.I570_01060	3.497e-150	486.0	COG4806@1|root,COG4806@2|Bacteria,1TS42@1239|Firmicutes,4HBQP@91061|Bacilli,4AZ7P@81852|Enterococcaceae	91061|Bacilli	G	Belongs to the rhamnose isomerase family	rhaA	GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0008740,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019299,GO:0019301,GO:0019318,GO:0019320,GO:0019321,GO:0019324,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575	2.7.1.5,5.3.1.14	ko:K00848,ko:K01813	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01902,R02437,R03014	RC00002,RC00017,RC00434	ko00000,ko00001,ko01000	-	-	-	RhaA
SX1_k127_352207_4	857293.CAAU_2021	2.416e-36	146.0	COG0235@1|root,COG0235@2|Bacteria,1TPDV@1239|Firmicutes,248KI@186801|Clostridia,36DCJ@31979|Clostridiaceae	186801|Clostridia	G	L-ribulose-5-phosphate 4-epimerase	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
SX1_k127_352207_2	344747.PM8797T_26560	2.237e-121	405.0	COG1070@1|root,COG1070@2|Bacteria,2IXYW@203682|Planctomycetes	203682|Planctomycetes	G	COG1070 Sugar (pentulose and hexulose)	-	-	2.7.1.5	ko:K00848	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01902,R03014	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
SX1_k127_352207_5	926569.ANT_22340	7.241e-31	138.0	COG2211@1|root,COG2211@2|Bacteria,2G6RZ@200795|Chloroflexi	200795|Chloroflexi	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX1_k127_352207_3	1382306.JNIM01000001_gene2032	5.73e-75	271.0	COG2272@1|root,COG2272@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	pnbA	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
SX1_k127_3525167_1	1048834.TC41_1491	4.452e-46	178.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,4HA2G@91061|Bacilli,278ZE@186823|Alicyclobacillaceae	91061|Bacilli	IQ	PFAM AMP-dependent synthetase and ligase	lcfA	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
SX1_k127_3525167_0	2325.TKV_c19870	7.911e-63	227.0	COG1249@1|root,COG1249@2|Bacteria,1TP1W@1239|Firmicutes,249R3@186801|Clostridia,42EWF@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
SX1_k127_3530138_1	391623.TERMP_01303	3.747e-47	176.0	COG1498@1|root,arCOG01923@2157|Archaea,2XUEA@28890|Euryarchaeota,242JP@183968|Thermococci	183968|Thermococci	J	C D box methylation guide ribonucleoprotein complex aNOP56 subunit	-	-	-	ko:K14564	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	Nop
SX1_k127_3530138_0	933801.Ahos_1388	1.725e-60	216.0	COG0513@1|root,arCOG00078@2157|Archaea,2XPRR@28889|Crenarchaeota	28889|Crenarchaeota	J	Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	flpA	GO:0000154,GO:0000494,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006325,GO:0006364,GO:0006396,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008213,GO:0008276,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016074,GO:0016569,GO:0016570,GO:0016571,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0022613,GO:0031123,GO:0031126,GO:0031167,GO:0032259,GO:0033967,GO:0034470,GO:0034641,GO:0034660,GO:0034963,GO:0036009,GO:0036211,GO:0042054,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043414,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051276,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140096,GO:0140098,GO:0140102,GO:1901360,GO:1901363,GO:1901564,GO:1990258,GO:1990259	-	ko:K04795	-	-	-	-	ko00000,ko03009	-	-	-	Fibrillarin
SX1_k127_3530138_2	391623.TERMP_00671	2.182e-45	173.0	COG0164@1|root,arCOG04121@2157|Archaea,2XWYC@28890|Euryarchaeota,242VW@183968|Thermococci	183968|Thermococci	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
SX1_k127_3530138_4	593117.TGAM_1316	4.47e-22	108.0	COG1395@1|root,arCOG04152@2157|Archaea,2XTMG@28890|Euryarchaeota,242IM@183968|Thermococci	183968|Thermococci	K	HTH-type transcriptional regulatory protein	-	-	-	ko:K07728	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
SX1_k127_3530138_5	572478.Vdis_0767	6.444e-13	76.0	COG4888@1|root,arCOG04136@2157|Archaea,2XRI7@28889|Crenarchaeota	28889|Crenarchaeota	J	Transcription elongation factor Elf1 like	-	-	-	-	-	-	-	-	-	-	-	-	Elf1
SX1_k127_3530138_3	1120951.AUBG01000012_gene1565	4.104e-29	129.0	COG0464@1|root,COG0464@2|Bacteria,4NH44@976|Bacteroidetes,1I1EH@117743|Flavobacteriia	976|Bacteroidetes	O	AAA ATPase, central domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA
SX1_k127_3552997_0	1121377.KB906398_gene2417	8.668e-72	254.0	COG3705@1|root,COG3705@2|Bacteria	2|Bacteria	E	histidine biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_3552997_1	96561.Dole_1480	1.009e-37	160.0	COG1032@1|root,COG1032@2|Bacteria,1RJ9Z@1224|Proteobacteria,42TDD@68525|delta/epsilon subdivisions,2WPHS@28221|Deltaproteobacteria,2MK5Y@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K22318	-	-	-	-	ko00000	-	-	-	Radical_SAM
SX1_k127_3590079_1	604354.TSIB_1416	1.305e-47	181.0	COG2413@1|root,arCOG04066@2157|Archaea,2XSZH@28890|Euryarchaeota,24347@183968|Thermococci	183968|Thermococci	S	Nucleotidyltransferase domain	-	-	-	ko:K07073	-	-	-	-	ko00000	-	-	-	NTP_transf_2
SX1_k127_3590079_2	572478.Vdis_1203	8.67e-27	113.0	COG1324@1|root,arCOG04231@2157|Archaea,2XR9J@28889|Crenarchaeota	28889|Crenarchaeota	P	PFAM CutA1 divalent ion tolerance protein	-	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
SX1_k127_3590079_0	439235.Dalk_3740	5.363e-56	203.0	COG0644@1|root,COG0644@2|Bacteria	2|Bacteria	C	geranylgeranyl reductase activity	cbrA	GO:0000166,GO:0003674,GO:0005488,GO:0008150,GO:0008152,GO:0009404,GO:0009987,GO:0019748,GO:0030153,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0048037,GO:0050660,GO:0050662,GO:0097159,GO:1901265,GO:1901363	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
SX1_k127_3596153_0	552811.Dehly_0641	1.227e-31	131.0	COG0521@1|root,COG0521@2|Bacteria,2G6YJ@200795|Chloroflexi	200795|Chloroflexi	H	May be involved in the biosynthesis of molybdopterin	-	-	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
SX1_k127_3596153_1	397945.Aave_1240	2.923e-19	92.0	COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,2VSIP@28216|Betaproteobacteria,4ADK5@80864|Comamonadaceae	28216|Betaproteobacteria	H	molybdopterin-guanine dinucleotide biosynthesis protein	mobB	-	-	ko:K03753	-	-	-	-	ko00000	-	-	-	MobB
SX1_k127_3598440_1	1121472.AQWN01000007_gene1046	2.768e-66	238.0	COG1454@1|root,COG1454@2|Bacteria,1V1AD@1239|Firmicutes,24ED6@186801|Clostridia	186801|Clostridia	C	Iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
SX1_k127_3598440_0	1121468.AUBR01000019_gene2622	8.194e-155	516.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,42ERP@68295|Thermoanaerobacterales	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
SX1_k127_3598440_2	946077.W5A_08822	7.692e-07	60.0	COG3568@1|root,COG3568@2|Bacteria,4NHXV@976|Bacteroidetes,1HX82@117743|Flavobacteriia	976|Bacteroidetes	S	Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
SX1_k127_360029_1	868131.MSWAN_0411	1.493e-12	70.0	COG0172@1|root,arCOG00403@2157|Archaea,2XTGA@28890|Euryarchaeota,23NQ1@183925|Methanobacteria	183925|Methanobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
SX1_k127_360029_0	1232437.KL662015_gene1287	1.559e-52	189.0	COG1765@1|root,COG1765@2|Bacteria,1N1T3@1224|Proteobacteria,42UFR@68525|delta/epsilon subdivisions,2WQ83@28221|Deltaproteobacteria,2MMSD@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
SX1_k127_3615949_0	70601.3257411	1.008e-31	138.0	COG1041@1|root,arCOG00047@2157|Archaea,2Y2EJ@28890|Euryarchaeota,2432J@183968|Thermococci	183968|Thermococci	L	Putative RNA methylase family UPF0020	-	-	-	-	-	-	-	-	-	-	-	-	UPF0020
SX1_k127_3615949_1	1121904.ARBP01000001_gene5687	1.22e-05	59.0	COG2304@1|root,COG2304@2|Bacteria,4NDUC@976|Bacteroidetes,47JUP@768503|Cytophagia	976|Bacteroidetes	S	PFAM von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
SX1_k127_3615949_2	935567.JAES01000055_gene6	0.0006441	47.0	COG2018@1|root,COG2018@2|Bacteria,1RIQC@1224|Proteobacteria,1S65Z@1236|Gammaproteobacteria,1X7KJ@135614|Xanthomonadales	135614|Xanthomonadales	S	Roadblock/LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
SX1_k127_3616275_0	1121091.AUMP01000006_gene4183	1.571e-41	169.0	COG0477@1|root,COG2814@2|Bacteria,1V0M2@1239|Firmicutes,4HCQZ@91061|Bacilli	91061|Bacilli	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,MFS_2,MFS_3,Sugar_tr
SX1_k127_3616275_1	574375.BAGA_19635	3.284e-37	157.0	COG0477@1|root,COG2814@2|Bacteria,1V0M2@1239|Firmicutes,4HCQZ@91061|Bacilli,1ZQZS@1386|Bacillus	91061|Bacilli	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,MFS_2,MFS_3,Sugar_tr
SX1_k127_3655130_3	269797.Mbar_A1599	1.679e-62	230.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota,2N92Q@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrD may act as the catalytic subunit	hdrD	GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016491,GO:0016667,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_8
SX1_k127_3655130_6	1121472.AQWN01000002_gene2121	1.823e-29	128.0	COG0109@1|root,COG0109@2|Bacteria,1TPS1@1239|Firmicutes,249CW@186801|Clostridia,262E6@186807|Peptococcaceae	186801|Clostridia	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
SX1_k127_3655130_12	1293048.CBMB010000001_gene109	3.111e-08	63.0	COG3413@1|root,arCOG02271@2157|Archaea,2XU8X@28890|Euryarchaeota,23THS@183963|Halobacteria	183963|Halobacteria	K	Bacterio-opsin activator HTH domain-containing protein	-	-	-	ko:K06930	-	-	-	-	ko00000	-	-	-	BAT,HTH_10
SX1_k127_3655130_5	673860.AciM339_0624	5.7e-38	153.0	COG0170@1|root,arCOG01880@2157|Archaea,2Y70G@28890|Euryarchaeota,3F32Z@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	PFAM phosphatidate cytidylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_3655130_4	439481.Aboo_0423	1.022e-59	216.0	COG1608@1|root,arCOG00860@2157|Archaea,2XSUI@28890|Euryarchaeota,3F2Y8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids	argB1	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016114,GO:0016740,GO:0016772,GO:0016776,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0102043,GO:1901576	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
SX1_k127_3655130_0	1121289.JHVL01000013_gene1638	1.137e-213	673.0	COG2368@1|root,COG2368@2|Bacteria,1TQ70@1239|Firmicutes,248RP@186801|Clostridia,36DTV@31979|Clostridiaceae	186801|Clostridia	Q	4-hydroxyphenylacetate 3-hydroxylase C terminal	abfD	-	1.14.14.9,4.2.1.120,5.3.3.3	ko:K00483,ko:K14534	ko00350,ko00650,ko00720,ko01100,ko01120,ko01200,ko01220,map00350,map00650,map00720,map01100,map01120,map01200,map01220	M00374,M00375	R02698,R03031,R03299,R10782	RC00046,RC01857,RC03277	ko00000,ko00001,ko00002,ko01000	-	-	-	HpaB,HpaB_N
SX1_k127_3655130_10	522772.Dacet_1724	2.322e-14	74.0	COG0753@1|root,COG0753@2|Bacteria,2GFBG@200930|Deferribacteres	200930|Deferribacteres	C	Catalase	-	-	1.11.1.6	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	M00532	R00009,R00602,R02670	RC00034,RC00767,RC02141,RC02755	ko00000,ko00001,ko00002,ko01000	-	-	-	Catalase,Catalase-rel
SX1_k127_3655130_1	177439.DP1287	1.975e-96	323.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,42N8V@68525|delta/epsilon subdivisions,2WJWB@28221|Deltaproteobacteria,2MMVM@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Pirin	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
SX1_k127_3655130_11	589924.Ferp_2456	1.777e-08	63.0	COG1374@1|root,arCOG00993@2157|Archaea,2Y0D1@28890|Euryarchaeota,2474B@183980|Archaeoglobi	183980|Archaeoglobi	J	PUA domain	-	-	-	ko:K07565	-	-	-	-	ko00000,ko03009	-	-	-	UPF0113
SX1_k127_3655130_2	693661.Arcve_0341	5.46e-63	231.0	COG0144@1|root,arCOG00973@2157|Archaea,2XUFZ@28890|Euryarchaeota,245P3@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N
SX1_k127_3655130_8	439481.Aboo_0623	1.318e-22	106.0	COG1437@1|root,arCOG01723@2157|Archaea,2XYQS@28890|Euryarchaeota,3F3BY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	TIGRFAM adenylyl cyclase CyaB	cyaB	GO:0003674,GO:0003824,GO:0004016,GO:0009975,GO:0016829,GO:0016849	4.6.1.1	ko:K05873	ko00230,map00230	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	CYTH
SX1_k127_3655130_9	439481.Aboo_0683	6.226e-17	87.0	COG0298@1|root,arCOG04427@2157|Archaea,2Y0AJ@28890|Euryarchaeota,3F2UW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	TIGRFAM hydrogenase assembly chaperone hypC hupF	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
SX1_k127_3655130_7	386456.JQKN01000001_gene1963	8.682e-26	116.0	COG2129@1|root,arCOG01145@2157|Archaea,2XXMZ@28890|Euryarchaeota,23P3K@183925|Methanobacteria	183925|Methanobacteria	S	Metallophosphoesterase, calcineurin superfamily	-	-	-	ko:K07096	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
SX1_k127_3655130_13	192952.MM_2280	3.315e-07	56.0	COG1418@1|root,arCOG01860@2157|Archaea,2XT54@28890|Euryarchaeota,2NBH8@224756|Methanomicrobia	224756|Methanomicrobia	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
SX1_k127_3671199_2	945713.IALB_1185	3.778e-07	63.0	COG1874@1|root,COG1874@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	3.2.1.23	ko:K01190,ko:K12308	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Cellulase,Glyco_hydro_35,Glyco_hydro_42,Glyco_hydro_42M,Sulfotransfer_2
SX1_k127_3671199_1	243233.MCA2118	2.118e-18	98.0	COG1449@1|root,COG1449@2|Bacteria,1R5KI@1224|Proteobacteria,1S0ID@1236|Gammaproteobacteria,1XGAT@135618|Methylococcales	135618|Methylococcales	G	Glycosyl hydrolase family 57	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
SX1_k127_3671199_0	1384049.CD29_15005	8.817e-26	109.0	2E6HR@1|root,33150@2|Bacteria,1VF6G@1239|Firmicutes,4IR8Y@91061|Bacilli	91061|Bacilli	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
SX1_k127_3679400_1	332101.JIBU02000065_gene4049	8.856e-11	70.0	COG0477@1|root,COG2814@2|Bacteria,1UZSN@1239|Firmicutes,249EU@186801|Clostridia,36ERH@31979|Clostridiaceae	186801|Clostridia	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX1_k127_3679400_0	1444309.JAQG01000087_gene2593	3.827e-20	100.0	COG2227@1|root,COG2227@2|Bacteria,1UHU9@1239|Firmicutes,4HFRY@91061|Bacilli,277EV@186822|Paenibacillaceae	91061|Bacilli	H	Methyltransferase small domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
SX1_k127_3683188_0	1460634.JCM19037_3252	4.579e-50	181.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,4H9YB@91061|Bacilli	91061|Bacilli	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
SX1_k127_3683188_1	1459636.NTE_00644	3.594e-24	108.0	arCOG07179@1|root,arCOG07179@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_3683188_2	634498.mru_1039	9.939e-09	64.0	COG0680@1|root,arCOG04429@2157|Archaea,2XXAF@28890|Euryarchaeota,23P79@183925|Methanobacteria	183925|Methanobacteria	C	hydrogenase maturation protease HycI	hycI	-	3.4.23.51	ko:K08315	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
SX1_k127_3695918_1	368408.Tpen_0376	8.486e-51	192.0	COG1498@1|root,arCOG01923@2157|Archaea,2XPYC@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Pre-mRNA processing ribonucleoprotein, binding	-	-	-	ko:K14564	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	Nop
SX1_k127_3695918_0	573064.Mefer_0665	4.82e-78	271.0	COG0167@1|root,arCOG00603@2157|Archaea,2XTMB@28890|Euryarchaeota,23QC5@183939|Methanococci	183939|Methanococci	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
SX1_k127_3695918_2	439481.Aboo_0831	1.393e-25	112.0	COG0543@1|root,arCOG02199@2157|Archaea,2XSY9@28890|Euryarchaeota,3F2KR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
SX1_k127_3697628_2	306263.Cla_1209	4.876e-12	75.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,42T11@68525|delta/epsilon subdivisions,2YQR4@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
SX1_k127_3697628_0	335541.Swol_2172	1.482e-147	478.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
SX1_k127_3697628_1	760011.Spico_1044	3.6e-94	321.0	COG0006@1|root,COG0673@1|root,COG0006@2|Bacteria,COG0673@2|Bacteria,2J6T7@203691|Spirochaetes	203691|Spirochaetes	E	Oxidoreductase family, C-terminal alpha beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX1_k127_3704333_9	883168.HMPREF9318_00928	6.013e-06	48.0	COG0323@1|root,COG0323@2|Bacteria,1TPGK@1239|Firmicutes,4HB34@91061|Bacilli	91061|Bacilli	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
SX1_k127_3704333_8	1198449.ACAM_1560	1.012e-08	63.0	COG2092@1|root,arCOG01988@2157|Archaea,2XR49@28889|Crenarchaeota	28889|Crenarchaeota	J	Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA	ef1b	-	-	ko:K03232	-	-	-	-	ko00000,ko03012	-	-	-	EF1_GNE
SX1_k127_3704333_6	1183377.Py04_0088	5.095e-17	81.0	COG2888@1|root,arCOG01989@2157|Archaea,2Y6JB@28890|Euryarchaeota,244R6@183968|Thermococci	183968|Thermococci	J	Domain of unknown function (DUF1610)	-	-	-	ko:K07580	-	-	-	-	ko00000	-	-	-	DUF1610
SX1_k127_3704333_3	565033.GACE_2176	1.356e-53	208.0	COG0433@1|root,arCOG00280@2157|Archaea,2Y7MA@28890|Euryarchaeota,246V1@183980|Archaeoglobi	183980|Archaeoglobi	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87,HAS-barrel
SX1_k127_3704333_0	368408.Tpen_0304	1.743e-256	811.0	COG0464@1|root,arCOG01308@2157|Archaea,2XPPI@28889|Crenarchaeota	28889|Crenarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
SX1_k127_3704333_2	933801.Ahos_0625	1.181e-82	286.0	COG0258@1|root,arCOG04050@2157|Archaea,2XPRH@28889|Crenarchaeota	28889|Crenarchaeota	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
SX1_k127_3704333_5	1220534.B655_2119	1.231e-17	89.0	COG1439@1|root,arCOG00721@2157|Archaea,2XWH2@28890|Euryarchaeota,23P50@183925|Methanobacteria	183925|Methanobacteria	V	PIN domain of ribonuclease	-	-	-	ko:K07060	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN_6
SX1_k127_3704333_4	386456.JQKN01000002_gene2741	6.823e-48	183.0	COG0061@1|root,arCOG01348@2157|Archaea,2XTP6@28890|Euryarchaeota,23NXW@183925|Methanobacteria	183925|Methanobacteria	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	Inositol_P,NAD_kinase
SX1_k127_3704333_1	456442.Mboo_1371	9.06e-154	500.0	COG1614@1|root,arCOG04360@2157|Archaea,2XU0D@28890|Euryarchaeota,2N95I@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex)	cdhC	-	-	ko:K00193	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00357,M00422	R09096,R10219	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
SX1_k127_3704333_7	573063.Metin_1031	8.811e-16	79.0	COG1880@1|root,arCOG04408@2157|Archaea,2XWPE@28890|Euryarchaeota,23R5P@183939|Methanococci	183939|Methanococci	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha- epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear	cdhB	-	-	ko:K00195	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00422	R07157	RC02800	ko00000,ko00001,ko00002	-	-	-	CO_dh
SX1_k127_3715080_6	1121481.AUAS01000011_gene5026	1.149e-13	75.0	COG0153@1|root,COG0153@2|Bacteria,4NFSD@976|Bacteroidetes,47K00@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the GHMP kinase family	-	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
SX1_k127_3715080_5	1365176.N186_05365	4.789e-15	85.0	COG0640@1|root,arCOG03859@2157|Archaea,2XR12@28889|Crenarchaeota	28889|Crenarchaeota	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
SX1_k127_3715080_3	754476.Q7A_50	9.133e-16	89.0	COG1821@1|root,COG1821@2|Bacteria,1RBY6@1224|Proteobacteria,1S7TK@1236|Gammaproteobacteria,4630X@72273|Thiotrichales	72273|Thiotrichales	S	ATP-utilizing enzyme (ATP-grasp superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3
SX1_k127_3715080_0	933801.Ahos_1245	7.608e-55	203.0	COG0462@1|root,arCOG00067@2157|Archaea,2XQE3@28889|Crenarchaeota	28889|Crenarchaeota	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
SX1_k127_3715080_1	523850.TON_1965	1.692e-51	189.0	COG2078@1|root,arCOG01336@2157|Archaea,2XUAP@28890|Euryarchaeota,242T1@183968|Thermococci	183968|Thermococci	S	AMMECR1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
SX1_k127_3715080_7	416591.Tlet_2027	0.0001335	49.0	COG2164@1|root,COG2164@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K09143	-	-	-	-	ko00000	-	-	-	Cyclophil_like
SX1_k127_3715080_2	5759.rna_EHI_198800-1	1.369e-28	121.0	COG0615@1|root,2SFY4@2759|Eukaryota,3XCRM@554915|Amoebozoa	554915|Amoebozoa	H	Cytidylyltransferase-like	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like
SX1_k127_3715080_4	1163730.FFONT_0784	2.083e-15	79.0	COG2178@1|root,arCOG04318@2157|Archaea,2XQKT@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Translin	-	-	-	ko:K07477	-	-	-	-	ko00000	-	-	-	Translin
SX1_k127_3718555_2	525904.Tter_1213	1.114e-18	89.0	COG1363@1|root,COG1363@2|Bacteria,2NQ9Q@2323|unclassified Bacteria	2|Bacteria	G	M42 glutamyl aminopeptidase	cel	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Peptidase_M42
SX1_k127_3718555_1	192952.MM_1387	3.003e-22	107.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,2N9AX@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,HHH_5,Helicase_C
SX1_k127_3718555_0	1037409.BJ6T_41850	5.212e-24	112.0	COG0596@1|root,COG0596@2|Bacteria,1QVJD@1224|Proteobacteria,2U3TI@28211|Alphaproteobacteria,3K6YT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Thioesterase domain	-	-	3.5.1.106	ko:K15357	ko00760,ko01120,map00760,map01120	M00622	R09126	RC00323,RC02431	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
SX1_k127_3718772_5	634498.mru_0239	0.0004845	45.0	COG4023@1|root,arCOG02957@2157|Archaea,2Y19U@28890|Euryarchaeota,23P99@183925|Methanobacteria	183925|Methanobacteria	U	but it may be involved in stabilization of the trimeric complex	secG	-	-	-	-	-	-	-	-	-	-	-	Sec61_beta
SX1_k127_3718772_4	1042877.GQS_00910	6.094e-33	130.0	COG1694@1|root,arCOG01084@2157|Archaea,2XZ0S@28890|Euryarchaeota,244B1@183968|Thermococci	183968|Thermococci	S	MazG nucleotide pyrophosphohydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	MazG
SX1_k127_3718772_1	1227497.C491_18229	1.014e-64	233.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTTP@28890|Euryarchaeota,23SW0@183963|Halobacteria	183963|Halobacteria	M	COG0451 Nucleoside-diphosphate-sugar epimerases	galE2	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
SX1_k127_3718772_3	529709.PYCH_03640	1.657e-44	177.0	COG1817@1|root,arCOG01395@2157|Archaea,2XT3W@28890|Euryarchaeota,242KM@183968|Thermococci	183968|Thermococci	S	Protein of unknown function (DUF354)	-	-	-	ko:K09726	-	-	-	-	ko00000	-	-	-	DUF354
SX1_k127_3718772_0	633148.Tagg_1211	6.242e-84	289.0	COG0451@1|root,arCOG01369@2157|Archaea,2XPYT@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
SX1_k127_3718772_2	391623.TERMP_00696	2.014e-64	236.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,242WX@183968|Thermococci	183968|Thermococci	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
SX1_k127_3722039_3	192952.MM_2155	8.939e-25	105.0	COG0099@1|root,arCOG01722@2157|Archaea,2XWHE@28890|Euryarchaeota,2N9RA@224756|Methanomicrobia	224756|Methanomicrobia	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rps13	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
SX1_k127_3722039_2	453591.Igni_0181	1.212e-43	166.0	COG0522@1|root,arCOG04239@2157|Archaea,2XQCT@28889|Crenarchaeota	28889|Crenarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
SX1_k127_3722039_1	565033.GACE_0208	1.613e-54	193.0	COG0100@1|root,arCOG04240@2157|Archaea,2XX1S@28890|Euryarchaeota,24666@183980|Archaeoglobi	183980|Archaeoglobi	J	Located on the platform of the 30S subunit	rps11	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
SX1_k127_3722039_0	177437.HRM2_05380	2.872e-77	276.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42NET@68525|delta/epsilon subdivisions,2WKDX@28221|Deltaproteobacteria,2MJA1@213118|Desulfobacterales	28221|Deltaproteobacteria	C	CoA binding domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
SX1_k127_3727695_0	1195236.CTER_3560	5.387e-128	420.0	COG1472@1|root,COG1472@2|Bacteria,1VSFU@1239|Firmicutes,25BFI@186801|Clostridia	186801|Clostridia	G	PFAM Glycosyl hydrolase family 3 C terminal domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
SX1_k127_3727695_1	760011.Spico_1043	4.719e-71	251.0	COG3246@1|root,COG3246@2|Bacteria	2|Bacteria	K	L-lysine catabolic process to acetate	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
SX1_k127_3728755_0	572478.Vdis_2231	5.14e-20	96.0	COG0585@1|root,arCOG04252@2157|Archaea,2XQXM@28889|Crenarchaeota	28889|Crenarchaeota	J	Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs	truD	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
SX1_k127_3728755_1	1123401.JHYQ01000009_gene2298	0.0007931	52.0	COG2885@1|root,COG2885@2|Bacteria,1R508@1224|Proteobacteria,1RS7G@1236|Gammaproteobacteria,46256@72273|Thiotrichales	72273|Thiotrichales	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
SX1_k127_3735145_1	877455.Metbo_0115	6.387e-84	295.0	COG1311@1|root,arCOG04455@2157|Archaea,2XSUG@28890|Euryarchaeota,23NMR@183925|Methanobacteria	183925|Methanobacteria	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polB	-	2.7.7.7	ko:K02323	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	DNA_pol_E_B
SX1_k127_3735145_2	304371.MCP_1798	3.261e-70	246.0	COG0047@1|root,arCOG00102@2157|Archaea,2XTPA@28890|Euryarchaeota,2N9HC@224756|Methanomicrobia	224756|Methanomicrobia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2755	GATase_5
SX1_k127_3735145_0	338963.Pcar_1328	2.724e-116	383.0	COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,42M08@68525|delta/epsilon subdivisions,2WITS@28221|Deltaproteobacteria,43S1C@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Phosphoribosylformylglycinamidine (FGAM) synthase	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,PurS
SX1_k127_3752432_0	1499967.BAYZ01000033_gene1080	2.529e-41	162.0	COG1410@1|root,COG1410@2|Bacteria	2|Bacteria	E	methionine synthase	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Met_synt_B12
SX1_k127_3755690_4	96561.Dole_1685	7.253e-108	357.0	COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,42NFZ@68525|delta/epsilon subdivisions,2WMBX@28221|Deltaproteobacteria,2MNG5@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
SX1_k127_3755690_6	1304888.ATWF01000001_gene2203	6.605e-58	207.0	COG0299@1|root,COG0299@2|Bacteria,2GFE7@200930|Deferribacteres	200930|Deferribacteres	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
SX1_k127_3755690_9	1184267.A11Q_2192	9.31e-05	46.0	COG3616@1|root,COG3616@2|Bacteria	2|Bacteria	E	Alanine racemase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N
SX1_k127_3755690_7	1033730.CAHG01000008_gene3241	8.17e-06	51.0	COG3616@1|root,COG3616@2|Bacteria,2GJMB@201174|Actinobacteria,4DMY5@85009|Propionibacteriales	201174|Actinobacteria	E	Alanine racemase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N
SX1_k127_3755690_8	1184267.A11Q_2192	1.771e-05	48.0	COG3616@1|root,COG3616@2|Bacteria	2|Bacteria	E	Alanine racemase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N
SX1_k127_3755690_5	521045.Kole_0990	1.825e-76	264.0	COG3718@1|root,COG3718@2|Bacteria	2|Bacteria	G	enzyme involved in inositol metabolism	iolCB	-	2.7.1.92,5.3.1.30	ko:K03337,ko:K03338	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R05661,R08503	RC00002,RC00017,RC00541	ko00000,ko00001,ko01000	-	-	-	KduI,PfkB
SX1_k127_3755690_0	986075.CathTA2_0598	1.503e-228	723.0	COG3962@1|root,COG3962@2|Bacteria,1UI18@1239|Firmicutes,4HCPP@91061|Bacilli	91061|Bacilli	E	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG)	iolD	GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009395,GO:0009987,GO:0016042,GO:0019637,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0046434,GO:0071704,GO:1901575	3.7.1.22	ko:K03336	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08603	RC02331	ko00000,ko00001,ko01000	-	-	iYO844.BSU39730	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
SX1_k127_3755690_3	521045.Kole_0988	1.444e-109	362.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	iolE	-	4.2.1.44	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R02782,R05659	RC00782,RC01448	ko00000,ko00001,ko01000	-	-	iECED1_1282.ECED1_0303	AP_endonuc_2
SX1_k127_3755690_2	697281.Mahau_2741	4.262e-113	374.0	COG0673@1|root,COG0673@2|Bacteria,1TP83@1239|Firmicutes,24B6F@186801|Clostridia,42I6E@68295|Thermoanaerobacterales	186801|Clostridia	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	Cupin_5,GFO_IDH_MocA,GFO_IDH_MocA_C
SX1_k127_3755690_1	697281.Mahau_2738	6.135e-131	426.0	COG0176@1|root,COG0176@2|Bacteria,1U9RA@1239|Firmicutes,24DCI@186801|Clostridia,42IE1@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Transaldolase	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
SX1_k127_3775316_4	368408.Tpen_1051	2.126e-14	81.0	COG1829@1|root,arCOG04263@2157|Archaea	2157|Archaea	S	kinase, sugar kinase superfamily	coaA	-	2.7.1.169	ko:K06982	ko00770,ko01100,map00770,map01100	-	R09378	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A3255	GHMP_kinases_N
SX1_k127_3775316_0	579137.Metvu_0127	9.842e-112	374.0	COG1503@1|root,arCOG01742@2157|Archaea,2XSV5@28890|Euryarchaeota,23QH0@183939|Methanococci	183939|Methanococci	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
SX1_k127_3775316_1	273063.STK_05320	6.521e-74	258.0	COG1701@1|root,arCOG04262@2157|Archaea,2XPPD@28889|Crenarchaeota	28889|Crenarchaeota	S	Pantothenate synthetase	-	-	6.3.2.36	ko:K09722	ko00410,ko00770,ko01100,map00410,map00770,map01100	-	R09379	RC00096,RC00141	ko00000,ko00001,ko01000	-	-	-	PPS_PS
SX1_k127_3775316_3	933801.Ahos_0647	5.278e-36	143.0	COG0456@1|root,arCOG00833@2157|Archaea,2XQJH@28889|Crenarchaeota	28889|Crenarchaeota	S	TIGRFAM ribosomal-protein-alanine acetyltransferase	-	GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
SX1_k127_3775316_5	673860.AciM339_0110	1.143e-08	59.0	COG4068@1|root,arCOG04390@2157|Archaea,2Y19A@28890|Euryarchaeota,3F3EH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Uncharacterized protein containing a Zn-ribbon (DUF2116)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2116
SX1_k127_3775316_2	186497.PF1843	2.11e-56	212.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,242QE@183968|Thermococci	183968|Thermococci	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
SX1_k127_3781_0	545696.HOLDEFILI_00237	1.466e-74	264.0	COG1453@1|root,COG1453@2|Bacteria,1TPBG@1239|Firmicutes,3VQ2E@526524|Erysipelotrichia	526524|Erysipelotrichia	S	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red,Fer4_17
SX1_k127_3781_1	439481.Aboo_1128	8.678e-65	231.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT7Q@28890|Euryarchaeota,3F39H@33867|unclassified Euryarchaeota	28890|Euryarchaeota	V	AAA domain, putative AbiEii toxin, Type IV TA system	trp2	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX1_k127_3781_3	8128.ENSONIP00000013134	5.703e-07	61.0	COG5151@1|root,KOG2807@2759|Eukaryota,38CIQ@33154|Opisthokonta,3BB63@33208|Metazoa,3CUR6@33213|Bilateria,47ZEM@7711|Chordata,48XPE@7742|Vertebrata,49RP5@7898|Actinopterygii	33208|Metazoa	KL	General transcription factor IIH	GTF2H2	GO:0000428,GO:0000438,GO:0000439,GO:0001109,GO:0001111,GO:0001112,GO:0001113,GO:0001120,GO:0002029,GO:0002031,GO:0003674,GO:0003676,GO:0003700,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005667,GO:0005669,GO:0005675,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006293,GO:0006294,GO:0006296,GO:0006351,GO:0006352,GO:0006353,GO:0006354,GO:0006355,GO:0006357,GO:0006360,GO:0006361,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0006396,GO:0006397,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006810,GO:0006897,GO:0006898,GO:0006950,GO:0006974,GO:0008135,GO:0008150,GO:0008152,GO:0008277,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009452,GO:0009628,GO:0009889,GO:0009966,GO:0009968,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010646,GO:0010648,GO:0016043,GO:0016070,GO:0016071,GO:0016192,GO:0016591,GO:0016604,GO:0016607,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0022401,GO:0022607,GO:0023051,GO:0023057,GO:0023058,GO:0030880,GO:0031323,GO:0031326,GO:0031334,GO:0031623,GO:0031974,GO:0031981,GO:0032774,GO:0032806,GO:0032991,GO:0033554,GO:0033683,GO:0034367,GO:0034622,GO:0034641,GO:0034645,GO:0034654,GO:0036260,GO:0043043,GO:0043112,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044451,GO:0044464,GO:0044798,GO:0045744,GO:0046483,GO:0047485,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051179,GO:0051234,GO:0051252,GO:0051716,GO:0055029,GO:0060255,GO:0061695,GO:0065003,GO:0065004,GO:0065007,GO:0070013,GO:0070911,GO:0071704,GO:0071824,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090575,GO:0097159,GO:0097659,GO:0098657,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1902554,GO:1902911,GO:1903506,GO:1990234,GO:2000112,GO:2001141	-	ko:K03142,ko:K14766	ko03022,ko03420,ko05203,map03022,map03420,map05203	M00290	-	-	ko00000,ko00001,ko00002,ko03009,ko03021,ko03400	-	-	-	C1_4,Ssl1
SX1_k127_3781_2	6500.XP_005097933.1	3.53e-26	115.0	KOG4423@1|root,KOG4423@2759|Eukaryota,38BWT@33154|Opisthokonta,3B9BE@33208|Metazoa,3DGBJ@33213|Bilateria	33208|Metazoa	U	Ras family	-	-	-	ko:K07918	-	-	-	-	ko00000,ko04031,ko04131	-	-	-	Ras
SX1_k127_3781_4	4956.XP_002494417.1	3.468e-05	56.0	KOG3886@1|root,KOG3886@2759|Eukaryota,38EME@33154|Opisthokonta,3NWKP@4751|Fungi,3QPDB@4890|Ascomycota,3RRBP@4891|Saccharomycetes,3RY0E@4893|Saccharomycetaceae	4751|Fungi	U	to Saccharomyces cerevisiae GTR1 (YML121W)	GTR1	GO:0000166,GO:0000322,GO:0000323,GO:0000324,GO:0000329,GO:0001101,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005764,GO:0005768,GO:0005770,GO:0005773,GO:0005774,GO:0006139,GO:0006325,GO:0006342,GO:0006348,GO:0006351,GO:0006355,GO:0006360,GO:0006383,GO:0006725,GO:0006807,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006995,GO:0006996,GO:0007154,GO:0007165,GO:0007264,GO:0008104,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009267,GO:0009605,GO:0009719,GO:0009889,GO:0009890,GO:0009892,GO:0009894,GO:0009895,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0009991,GO:0010008,GO:0010033,GO:0010243,GO:0010467,GO:0010468,GO:0010506,GO:0010507,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0010646,GO:0010647,GO:0010648,GO:0012505,GO:0015698,GO:0016020,GO:0016043,GO:0016070,GO:0016458,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0018130,GO:0019001,GO:0019219,GO:0019222,GO:0019438,GO:0023051,GO:0023052,GO:0023056,GO:0023057,GO:0031090,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031329,GO:0031330,GO:0031410,GO:0031667,GO:0031668,GO:0031669,GO:0031902,GO:0031982,GO:0032006,GO:0032007,GO:0032008,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032774,GO:0032991,GO:0033036,GO:0033365,GO:0033554,GO:0034448,GO:0034613,GO:0034641,GO:0034645,GO:0034654,GO:0035556,GO:0035639,GO:0036094,GO:0040029,GO:0042221,GO:0042594,GO:0043167,GO:0043168,GO:0043170,GO:0043200,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043562,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044437,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0045814,GO:0045892,GO:0045934,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051179,GO:0051234,GO:0051252,GO:0051253,GO:0051276,GO:0051641,GO:0051716,GO:0060255,GO:0065007,GO:0070727,GO:0070887,GO:0071229,GO:0071230,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0071840,GO:0072657,GO:0072665,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0097708,GO:0098588,GO:0098796,GO:0098805,GO:0098852,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902532,GO:1902533,GO:1902679,GO:1903432,GO:1903506,GO:1903507,GO:1903778,GO:1904262,GO:1904263,GO:1990131,GO:2000112,GO:2000113,GO:2001141	-	ko:K16185	ko04140,ko04150,map04140,map04150	-	-	-	ko00000,ko00001	-	-	-	Gtr1_RagA
SX1_k127_3787236_3	589924.Ferp_2446	1.525e-07	54.0	COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,246NU@183980|Archaeoglobi	183980|Archaeoglobi	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
SX1_k127_3787236_0	1484460.JSWG01000015_gene1184	6.973e-171	547.0	COG0161@1|root,COG0161@2|Bacteria	2|Bacteria	H	adenosylmethionine-8-amino-7-oxononanoate transaminase activity	-	-	2.6.1.55	ko:K15372	ko00410,ko00430,ko01100,map00410,map00430,map01100	-	R00908,R01684	RC00006,RC00062	ko00000,ko00001,ko01000	-	-	-	Aminotran_3
SX1_k127_3787236_1	96561.Dole_1686	2.042e-99	335.0	COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,42RTN@68525|delta/epsilon subdivisions,2WNYI@28221|Deltaproteobacteria	1224|Proteobacteria	E	PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
SX1_k127_3787236_2	96561.Dole_1685	3.861e-33	132.0	COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,42NFZ@68525|delta/epsilon subdivisions,2WMBX@28221|Deltaproteobacteria,2MNG5@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
SX1_k127_379370_0	374847.Kcr_0638	3.922e-19	99.0	arCOG02559@1|root,arCOG02559@2157|Archaea	2157|Archaea	P	by modhmm	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
SX1_k127_379370_1	148304.MAPG_08511T0	4.092e-06	58.0	KOG3947@1|root,KOG3947@2759|Eukaryota,39YJB@33154|Opisthokonta,3P0W5@4751|Fungi,3QN9M@4890|Ascomycota,215IR@147550|Sordariomycetes,41Q0P@639021|Magnaporthales	4751|Fungi	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
SX1_k127_3844788_2	342451.SSP0028	2.537e-57	211.0	COG0863@1|root,COG0863@2|Bacteria,1VC9K@1239|Firmicutes,4HSVW@91061|Bacilli	91061|Bacilli	L	DNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
SX1_k127_3844788_0	1379270.AUXF01000003_gene3556	4.904e-192	619.0	COG0443@1|root,COG0443@2|Bacteria,1ZT75@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
SX1_k127_3844788_1	457570.Nther_1184	3.817e-92	315.0	COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,248EM@186801|Clostridia	186801|Clostridia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
SX1_k127_3844788_3	717605.Theco_2404	5.292e-19	96.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,4HIRK@91061|Bacilli,26X19@186822|Paenibacillaceae	91061|Bacilli	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0017076,GO:0030234,GO:0030246,GO:0030247,GO:0030554,GO:0036094,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
SX1_k127_384838_0	246194.CHY_0845	1.097e-29	121.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,42I0M@68295|Thermoanaerobacterales	186801|Clostridia	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
SX1_k127_384838_1	592015.HMPREF1705_00463	4.541e-29	120.0	COG2154@1|root,COG2154@2|Bacteria	2|Bacteria	H	pterin-4-alpha-carbinolamine dehydratase	phhB	GO:0003674,GO:0003824,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008124,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019438,GO:0019751,GO:0034311,GO:0034312,GO:0034641,GO:0042558,GO:0042559,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
SX1_k127_384838_2	604354.TSIB_1238	6.154e-22	98.0	COG1917@1|root,arCOG02994@2157|Archaea,2XZAN@28890|Euryarchaeota,2446X@183968|Thermococci	183968|Thermococci	S	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SX1_k127_385237_0	573063.Metin_0356	1.006e-136	452.0	COG0034@1|root,arCOG00093@2157|Archaea,2XSWJ@28890|Euryarchaeota,23Q7H@183939|Methanococci	183939|Methanococci	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7,Pribosyltran
SX1_k127_385237_1	448385.sce1051	1.717e-31	126.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,42M8A@68525|delta/epsilon subdivisions,2WJY0@28221|Deltaproteobacteria,2YUIU@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the SAICAR synthetase family	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
SX1_k127_3855162_2	368408.Tpen_0792	2.036e-68	254.0	COG0297@1|root,arCOG01420@2157|Archaea,2XPWR@28889|Crenarchaeota	28889|Crenarchaeota	M	Starch synthase catalytic domain	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
SX1_k127_3855162_4	1094980.Mpsy_1456	4.682e-34	141.0	COG1938@1|root,arCOG00347@2157|Archaea,2XT93@28890|Euryarchaeota,2N9KT@224756|Methanomicrobia	224756|Methanomicrobia	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
SX1_k127_3855162_7	70601.3258266	6.615e-17	83.0	COG2451@1|root,arCOG04304@2157|Archaea,2Y0KT@28890|Euryarchaeota,244KT@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL33 family	rpl35ae	-	-	ko:K02917	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35Ae
SX1_k127_3855162_0	374847.Kcr_0992	1.175e-154	499.0	COG0112@1|root,arCOG00070@2157|Archaea	2157|Archaea	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
SX1_k127_3855162_9	410358.Mlab_0742	4.845e-12	76.0	COG1340@1|root,arCOG01159@2157|Archaea,2XU21@28890|Euryarchaeota,2N93Q@224756|Methanomicrobia	224756|Methanomicrobia	S	archaeal coiled-coil protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_3855162_3	399549.Msed_2231	2.28e-52	195.0	COG2519@1|root,arCOG00978@2157|Archaea,2XPU6@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM tRNA methyltransferase complex GCD14 subunit	-	-	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14,GCD14_N
SX1_k127_3855162_1	1304880.JAGB01000001_gene427	4.643e-103	351.0	COG1902@1|root,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,24C9J@186801|Clostridia	186801|Clostridia	C	PFAM NADH flavin oxidoreductase NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
SX1_k127_3855162_6	1183377.Py04_1583	3.094e-27	117.0	COG1522@1|root,arCOG01580@2157|Archaea,2XWJA@28890|Euryarchaeota,243ZM@183968|Thermococci	183968|Thermococci	K	transcription regulator activity	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
SX1_k127_3855162_5	589924.Ferp_2508	7.082e-31	126.0	COG0432@1|root,arCOG04214@2157|Archaea,2XYW0@28890|Euryarchaeota,2469M@183980|Archaeoglobi	183980|Archaeoglobi	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
SX1_k127_3855162_8	1158345.JNLL01000001_gene780	1.198e-14	82.0	COG2229@1|root,COG2229@2|Bacteria,2G4BW@200783|Aquificae	200783|Aquificae	S	small GTP-binding protein	-	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	ATP_bind_1,Arf
SX1_k127_3855162_10	224325.AF_1493	4.38e-08	57.0	COG2036@1|root,arCOG02144@2157|Archaea,2XZYK@28890|Euryarchaeota,247BU@183980|Archaeoglobi	183980|Archaeoglobi	L	PFAM Transcription factor CBF NF-Y histone domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CBFD_NFYB_HMF
SX1_k127_3862491_2	1232443.BAIA02000080_gene929	0.0002445	46.0	COG1478@1|root,COG1478@2|Bacteria,1TSTY@1239|Firmicutes,249IH@186801|Clostridia,267TB@186813|unclassified Clostridiales	186801|Clostridia	S	F420-0:Gamma-glutamyl ligase	-	-	-	-	-	-	-	-	-	-	-	-	F420_ligase
SX1_k127_3862491_1	406327.Mevan_1287	5.725e-07	60.0	arCOG02527@1|root,arCOG03439@1|root,arCOG02527@2157|Archaea,arCOG03439@2157|Archaea,2XXWR@28890|Euryarchaeota,23RJF@183939|Methanococci	183939|Methanococci	S	PFAM periplasmic copper-binding	-	-	-	-	-	-	-	-	-	-	-	-	NosD
SX1_k127_3862491_0	269797.Mbar_A2314	3.142e-72	256.0	COG0294@1|root,arCOG01978@2157|Archaea,2Y879@28890|Euryarchaeota,2N9M1@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM dihydropteroate synthase, DHPS	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
SX1_k127_3863311_1	1047013.AQSP01000142_gene150	2.831e-23	101.0	COG3250@1|root,COG3250@2|Bacteria,2NQEM@2323|unclassified Bacteria	2|Bacteria	G	Glycosyl hydrolases family 2, TIM barrel domain	lacZ	GO:0003674,GO:0003824,GO:0004553,GO:0004565,GO:0005575,GO:0005975,GO:0005984,GO:0005988,GO:0005990,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009341,GO:0009987,GO:0015925,GO:0016052,GO:0016787,GO:0016798,GO:0032991,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0046352,GO:0071704,GO:1901575,GO:1902494	3.2.1.23,3.2.1.31	ko:K01190,ko:K01195	ko00040,ko00052,ko00511,ko00531,ko00600,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00052,map00511,map00531,map00600,map00860,map00944,map00983,map01100,map01110,map04142	M00014,M00076,M00077,M00078,M00129	R01105,R01478,R01678,R03355,R04783,R04979,R06114,R07818,R08127,R08260,R10830	RC00049,RC00055,RC00171,RC00452,RC00529,RC00530,RC00714,RC01251	ko00000,ko00001,ko00002,ko01000	-	-	-	Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
SX1_k127_3863311_2	36875.HQ29_06100	2.641e-18	88.0	COG3250@1|root,COG3250@2|Bacteria,4NF3W@976|Bacteroidetes,2FM0P@200643|Bacteroidia,22W8R@171551|Porphyromonadaceae	976|Bacteroidetes	G	beta-galactosidase	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Bgal_small_N,DUF4981,F5_F8_type_C,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
SX1_k127_3863311_0	573063.Metin_0899	2.273e-92	316.0	COG1223@1|root,arCOG04163@2157|Archaea,2XUPW@28890|Euryarchaeota,23Q25@183939|Methanococci	183939|Methanococci	O	PFAM AAA ATPase central domain protein	-	-	-	ko:K07392	-	-	-	-	ko00000	-	-	-	AAA
SX1_k127_386706_0	556261.HMPREF0240_00099	1.764e-110	365.0	COG4733@1|root,COG4733@2|Bacteria,1UIP7@1239|Firmicutes,25EPY@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF2961)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2961
SX1_k127_386996_0	28564.XP_002340131.1	9.655e-97	335.0	KOG4155@1|root,KOG4155@2759|Eukaryota,3AG0Y@33154|Opisthokonta,3Q4RG@4751|Fungi,3RN16@4890|Ascomycota,20UKC@147545|Eurotiomycetes,3SE9V@5042|Eurotiales	4751|Fungi	S	Encoded by	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,NACHT,WD40
SX1_k127_387_0	565033.GACE_1903	8.125e-16	89.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota,245SC@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S dicluster domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_17
SX1_k127_387_1	1121324.CLIT_10c01540	6.614e-09	59.0	COG0500@1|root,COG2226@2|Bacteria,1VAEA@1239|Firmicutes,24G83@186801|Clostridia	186801|Clostridia	Q	Methylase involved in ubiquinone menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31,Ubie_methyltran
SX1_k127_3877637_1	641107.CDLVIII_0615	8.949e-09	61.0	COG2221@1|root,COG2221@2|Bacteria,1VBGQ@1239|Firmicutes,25BD2@186801|Clostridia,36WDQ@31979|Clostridiaceae	186801|Clostridia	C	Putative redox-active protein (C_GCAxxG_C_C)	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
SX1_k127_3877637_0	335541.Swol_2134	8.495e-22	96.0	COG0714@1|root,COG0714@2|Bacteria,1TRSV@1239|Firmicutes,24ARU@186801|Clostridia,42KGC@68298|Syntrophomonadaceae	186801|Clostridia	S	Magnesium chelatase, subunit ChlI	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
SX1_k127_388176_1	415426.Hbut_1102	8.267e-14	75.0	COG2219@1|root,arCOG03013@2157|Archaea,2XQ8M@28889|Crenarchaeota	28889|Crenarchaeota	L	Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priL	-	-	ko:K18882	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_lrg
SX1_k127_388176_0	1365176.N186_04465	2.533e-46	183.0	COG1467@1|root,arCOG04110@2157|Archaea,2XQI5@28889|Crenarchaeota	28889|Crenarchaeota	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901363,GO:1901576	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
SX1_k127_388435_0	439481.Aboo_1424	3.221e-31	132.0	COG1234@1|root,arCOG00501@2157|Archaea,2XTJ9@28890|Euryarchaeota,3F2KC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
SX1_k127_388435_1	755731.Clo1100_3209	1.382e-13	83.0	COG0673@1|root,COG0673@2|Bacteria,1TP83@1239|Firmicutes,248XQ@186801|Clostridia,36F4R@31979|Clostridiaceae	186801|Clostridia	S	Oxidoreductase family, C-terminal alpha beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX1_k127_3889774_5	411467.BACCAP_01478	1.886e-69	245.0	COG1233@1|root,COG1233@2|Bacteria,1TS4A@1239|Firmicutes,249K1@186801|Clostridia	186801|Clostridia	Q	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
SX1_k127_3889774_3	1114972.AUAW01000026_gene771	1.285e-101	344.0	COG1018@1|root,COG1018@2|Bacteria,1U7BA@1239|Firmicutes,4IH6A@91061|Bacilli,3F99Q@33958|Lactobacillaceae	91061|Bacilli	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
SX1_k127_3889774_4	485913.Krac_10632	1.612e-76	264.0	2EEUQ@1|root,338N7@2|Bacteria	2|Bacteria	S	Aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,gag-asp_proteas
SX1_k127_3889774_6	864702.OsccyDRAFT_2779	2.876e-33	134.0	COG0454@1|root,COG0456@2|Bacteria,1G5EH@1117|Cyanobacteria	1117|Cyanobacteria	K	PFAM Acetyltransferase (GNAT) family	-	-	2.3.1.57	ko:K00657	ko00330,ko01100,ko04216,map00330,map01100,map04216	M00135	R01154	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
SX1_k127_3889774_1	357809.Cphy_1628	5.291e-120	394.0	COG1853@1|root,COG1853@2|Bacteria,1UZS7@1239|Firmicutes,24FF8@186801|Clostridia	186801|Clostridia	S	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_3889774_7	1128421.JAGA01000001_gene2407	2.026e-19	98.0	COG1402@1|root,COG1402@2|Bacteria	2|Bacteria	I	creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
SX1_k127_3889774_2	224325.AF_1772	1.552e-112	385.0	COG0318@1|root,arCOG00856@2157|Archaea,2XSZG@28890|Euryarchaeota,246KT@183980|Archaeoglobi	183980|Archaeoglobi	I	to SP P29212 GB L02649 GB X70994 PID 581070 GB U00096 percent identity	-	-	6.2.1.3	ko:K00666,ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
SX1_k127_3889774_8	456442.Mboo_0330	4.082e-19	88.0	COG0425@1|root,arCOG02062@2157|Archaea	2157|Archaea	O	redox protein regulator of disulfide bond formation	-	GO:0008150,GO:0009987,GO:0019725,GO:0042592,GO:0048878,GO:0055082,GO:0065007,GO:0065008	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
SX1_k127_3889774_0	1499689.CCNN01000013_gene3018	5.576e-122	408.0	COG2317@1|root,COG2317@2|Bacteria,1TPS6@1239|Firmicutes,249NK@186801|Clostridia,36F32@31979|Clostridiaceae	186801|Clostridia	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
SX1_k127_3904665_2	709991.Odosp_2289	3.934e-19	93.0	COG0204@1|root,COG3176@1|root,COG0204@2|Bacteria,COG3176@2|Bacteria,4NF25@976|Bacteroidetes,2FSAD@200643|Bacteroidia,22XTQ@171551|Porphyromonadaceae	976|Bacteroidetes	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_5,Acyltransferase
SX1_k127_3904665_0	1313421.JHBV01000043_gene2992	1.632e-161	536.0	COG2366@1|root,COG2366@2|Bacteria,4NEIX@976|Bacteroidetes,1IPU7@117747|Sphingobacteriia	976|Bacteroidetes	S	COG2366 Protein related to penicillin acylase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
SX1_k127_3904665_1	1123239.KB898627_gene3481	1.22e-22	100.0	COG0657@1|root,COG0657@2|Bacteria,1UYX6@1239|Firmicutes,4HEMG@91061|Bacilli	91061|Bacilli	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
SX1_k127_3906162_1	1365176.N186_08280	3.786e-26	112.0	COG1122@1|root,arCOG00188@2157|Archaea,2XPVI@28889|Crenarchaeota	28889|Crenarchaeota	P	ABC transporter	-	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
SX1_k127_3906162_0	485916.Dtox_1967	6.167e-65	233.0	COG0488@1|root,COG0488@2|Bacteria,1UI2R@1239|Firmicutes,25EBF@186801|Clostridia,267CI@186807|Peptococcaceae	186801|Clostridia	S	PFAM ABC transporter related	-	-	-	ko:K16785,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
SX1_k127_3906162_2	186497.PF0384	4.093e-12	72.0	COG0618@1|root,arCOG01565@2157|Archaea,2XWQV@28890|Euryarchaeota,2433D@183968|Thermococci	183968|Thermococci	S	DHH family	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
SX1_k127_3906162_3	1034808.GIG_00436	1.787e-05	54.0	COG3887@1|root,COG3887@2|Bacteria,3WSY1@544448|Tenericutes	544448|Tenericutes	T	binds to the 23S rRNA	rplI	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1,Ribosomal_L9_C,Ribosomal_L9_N
SX1_k127_3908783_2	909663.KI867150_gene399	3.462e-79	273.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria,2MR16@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Molybdopterin oxidoreductase, Fe4S4	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
SX1_k127_3908783_0	857293.CAAU_0207	6.097e-238	749.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,36EMP@31979|Clostridiaceae	186801|Clostridia	C	Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	hymB	-	1.12.1.3,1.17.1.11,1.6.5.3	ko:K00335,ko:K18331,ko:K22339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
SX1_k127_3908783_4	309803.CTN_1069	7.852e-39	150.0	COG1905@1|root,COG1905@2|Bacteria,2GE0M@200918|Thermotogae	200918|Thermotogae	C	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit	-	-	1.12.1.4	ko:K17999	-	-	-	-	ko00000,ko01000	-	-	-	2Fe-2S_thioredx
SX1_k127_3908783_3	269797.Mbar_A0061	3.982e-73	256.0	COG1899@1|root,arCOG04142@2157|Archaea,2XSTD@28890|Euryarchaeota,2N91B@224756|Methanomicrobia	224756|Methanomicrobia	O	Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue	dys-2	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
SX1_k127_3908783_1	385682.AFSL01000078_gene1049	2.961e-106	368.0	COG0018@1|root,COG0018@2|Bacteria,4NE7Q@976|Bacteroidetes,2FN06@200643|Bacteroidia,3XIZY@558415|Marinilabiliaceae	976|Bacteroidetes	J	Arginyl tRNA synthetase N terminal dom	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
SX1_k127_3908783_5	342949.PNA2_0889	5.272e-30	123.0	COG0127@1|root,arCOG04184@2157|Archaea,2XTS4@28890|Euryarchaeota,243RS@183968|Thermococci	183968|Thermococci	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
SX1_k127_3919445_3	1459636.NTE_02760	8.88e-46	169.0	COG0012@1|root,arCOG00357@2157|Archaea,41S71@651137|Thaumarchaeota	651137|Thaumarchaeota	J	GTPase of unknown function C-terminal	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
SX1_k127_3919445_11	1449345.JHWC01000009_gene1667	2.076e-17	96.0	COG0433@1|root,COG0433@2|Bacteria,1MYA6@1224|Proteobacteria	1224|Proteobacteria	S	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
SX1_k127_3919445_0	224325.AF_1451	2.896e-154	506.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,246XE@183980|Archaeoglobi	183980|Archaeoglobi	O	TCP-1/cpn60 chaperonin family	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
SX1_k127_3919445_4	192952.MM_3074	1.01e-36	145.0	COG2042@1|root,arCOG04733@2157|Archaea,2XVBD@28890|Euryarchaeota,2N9PH@224756|Methanomicrobia	224756|Methanomicrobia	J	pre-rRNA processing protein involved in ribosome biogenesis	-	-	-	ko:K09140	-	-	-	-	ko00000,ko03009	-	-	-	RLI,Ribo_biogen_C
SX1_k127_3919445_1	579137.Metvu_1306	3.797e-122	402.0	COG0206@1|root,arCOG02201@2157|Archaea,2XSV8@28890|Euryarchaeota,23QJU@183939|Methanococci	183939|Methanococci	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
SX1_k127_3919445_5	877455.Metbo_2373	2.58e-31	131.0	COG1094@1|root,arCOG04150@2157|Archaea,2XUHX@28890|Euryarchaeota,23P1J@183925|Methanobacteria	183925|Methanobacteria	J	KH domain protein	-	-	-	ko:K06961	-	-	-	-	ko00000,ko03009	-	-	-	KH_1
SX1_k127_3919445_2	693661.Arcve_1602	1.939e-54	200.0	COG1718@1|root,arCOG01180@2157|Archaea,2XU2H@28890|Euryarchaeota,245RP@183980|Archaeoglobi	183980|Archaeoglobi	T	Serine threonine protein kinase involved in cell cycle control	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
SX1_k127_3919445_10	868131.MSWAN_1863	1.069e-18	97.0	COG0231@1|root,COG1499@1|root,arCOG04149@2157|Archaea,arCOG04277@2157|Archaea,2XUAI@28890|Euryarchaeota,23NXE@183925|Methanobacteria	183925|Methanobacteria	J	NMD3 family	-	-	-	ko:K07562	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko03009	-	-	-	NMD3
SX1_k127_3919445_16	399550.Smar_1103	2.57e-09	61.0	COG2412@1|root,arCOG04051@2157|Archaea,2XR9B@28889|Crenarchaeota	28889|Crenarchaeota	S	Protein of unknown function (DUF424)	-	-	-	ko:K09148	-	-	-	-	ko00000	-	-	-	DUF424
SX1_k127_3919445_6	439481.Aboo_1117	6.721e-30	123.0	COG1601@1|root,COG3269@1|root,arCOG01640@2157|Archaea,arCOG01641@2157|Archaea,2XTVZ@28890|Euryarchaeota,3F2N9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2b	-	-	ko:K03238	ko03013,map03013	-	-	-	ko00000,ko00001,ko01009,ko03012	-	-	-	TRAM,eIF-5_eIF-2B
SX1_k127_3919445_9	1229783.C273_08421	1.215e-20	105.0	COG0019@1|root,COG0019@2|Bacteria,1TPE9@1239|Firmicutes,4H9XW@91061|Bacilli,4GX30@90964|Staphylococcaceae	91061|Bacilli	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
SX1_k127_3919445_13	224719.Abm4_1640	3.965e-11	73.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,23P1D@183925|Methanobacteria	183925|Methanobacteria	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
SX1_k127_3919445_17	1069080.KB913028_gene217	4.436e-06	49.0	2DREN@1|root,33BEG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_3919445_8	596152.DesU5LDRAFT_2681	9.751e-21	93.0	2DN97@1|root,32W7A@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_3919445_7	511051.CSE_12570	8.645e-26	113.0	COG1100@1|root,COG1100@2|Bacteria	2|Bacteria	S	GTP binding	mglA	GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf,DUF697,MMR_HSR1
SX1_k127_3920324_2	1408415.JHXL01000002_gene309	5.875e-40	161.0	COG3425@1|root,COG3425@2|Bacteria	2|Bacteria	I	synthase	mvaS	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	HMG_CoA_synt_C,HMG_CoA_synt_N
SX1_k127_3920324_1	224719.Abm4_0676	2.215e-44	171.0	COG0020@1|root,arCOG01532@2157|Archaea,2XSW1@28890|Euryarchaeota,23NKV@183925|Methanobacteria	183925|Methanobacteria	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids	uppS	-	2.5.1.89	ko:K15888	ko00900,map00900	-	R09730	RC00279,RC02839	ko00000,ko00001,ko01000	-	-	-	Prenyltransf
SX1_k127_3920324_0	224308.BSU40820	3.855e-145	483.0	COG1331@1|root,COG1331@2|Bacteria,1TPRD@1239|Firmicutes,4H9ZS@91061|Bacilli,1ZCEN@1386|Bacillus	91061|Bacilli	O	COG1331 Highly conserved protein containing a thioredoxin domain	yyaL	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Glyco_hydro_9,Thioredox_DsbH
SX1_k127_3920324_3	309800.C498_09179	6.337e-32	128.0	COG0088@1|root,arCOG04243@2157|Archaea,2XWK0@28890|Euryarchaeota,23VBN@183963|Halobacteria	183963|Halobacteria	J	Belongs to the universal ribosomal protein uS9 family	rps9p	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
SX1_k127_3923307_0	264201.pc0038	1.199e-57	213.0	COG4886@1|root,COG4886@2|Bacteria,2JH6G@204428|Chlamydiae	204428|Chlamydiae	S	Leucine-rich repeats, outliers	-	-	-	-	-	-	-	-	-	-	-	-	LRR_8
SX1_k127_3923307_2	7460.GB49571-PA	1.446e-09	66.0	COG4886@1|root,KOG0619@2759|Eukaryota,38C70@33154|Opisthokonta,3BCK5@33208|Metazoa,3CTCV@33213|Bilateria,41VTX@6656|Arthropoda,3SFRR@50557|Insecta,46HXH@7399|Hymenoptera	33208|Metazoa	S	Leucine-rich repeats, typical (most populated) subfamily	SHOC2	GO:0000164,GO:0002119,GO:0002164,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007169,GO:0007264,GO:0007265,GO:0007275,GO:0007517,GO:0008150,GO:0008157,GO:0008287,GO:0008543,GO:0009719,GO:0009791,GO:0009966,GO:0009967,GO:0009987,GO:0010033,GO:0010646,GO:0010647,GO:0010921,GO:0016020,GO:0017016,GO:0019208,GO:0019220,GO:0019222,GO:0019888,GO:0019899,GO:0019902,GO:0019903,GO:0023051,GO:0023052,GO:0023056,GO:0030234,GO:0031267,GO:0031323,GO:0031344,GO:0031399,GO:0031974,GO:0031981,GO:0032268,GO:0032501,GO:0032502,GO:0032991,GO:0035303,GO:0035304,GO:0035556,GO:0040025,GO:0042221,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043666,GO:0044344,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0046578,GO:0046579,GO:0048513,GO:0048518,GO:0048522,GO:0048569,GO:0048583,GO:0048584,GO:0048731,GO:0048856,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051020,GO:0051056,GO:0051057,GO:0051128,GO:0051171,GO:0051174,GO:0051246,GO:0051336,GO:0051716,GO:0060255,GO:0061061,GO:0065007,GO:0065009,GO:0070013,GO:0070848,GO:0070887,GO:0071310,GO:0071363,GO:0071495,GO:0071774,GO:0071944,GO:0080090,GO:0098772,GO:1902494,GO:1902531,GO:1902533,GO:1903293	-	ko:K19613	ko04014,map04014	-	-	-	ko00000,ko00001	-	-	-	LRR_1,LRR_8
SX1_k127_3923307_1	479433.Caci_0032	1.021e-31	131.0	COG0500@1|root,COG2226@2|Bacteria,2IPTP@201174|Actinobacteria	201174|Actinobacteria	H	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
SX1_k127_3923307_3	880073.Calab_3047	2.617e-07	59.0	COG2048@1|root,COG2048@2|Bacteria,2NQP7@2323|unclassified Bacteria	2|Bacteria	C	Heterodisulfide reductase subunit B	hdrB	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
SX1_k127_3929315_0	9818.XP_007953343.1	5.784e-50	188.0	KOG1610@1|root,KOG1610@2759|Eukaryota,38BV4@33154|Opisthokonta,3BA6X@33208|Metazoa,3CSFV@33213|Bilateria,4805J@7711|Chordata,48ZM2@7742|Vertebrata,3JEDY@40674|Mammalia,353NH@311790|Afrotheria	33208|Metazoa	Q	Enoyl-(Acyl carrier protein) reductase	HSD17B6	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006091,GO:0006629,GO:0006694,GO:0006702,GO:0006706,GO:0006710,GO:0008150,GO:0008152,GO:0008202,GO:0008209,GO:0008610,GO:0009055,GO:0009056,GO:0009058,GO:0009987,GO:0010817,GO:0016042,GO:0016229,GO:0016491,GO:0016614,GO:0016616,GO:0022900,GO:0033764,GO:0034754,GO:0042445,GO:0042446,GO:0042447,GO:0044237,GO:0044238,GO:0044249,GO:0044464,GO:0047035,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	1.1.1.105,1.1.1.239,1.1.1.30,1.1.1.62	ko:K00019,ko:K11154,ko:K13369	ko00072,ko00140,ko00650,ko00830,ko01100,map00072,map00140,map00650,map00830,map01100	M00088	R01361,R01836,R02124,R02352,R02353,R04681,R04682,R08945,R08980	RC00117,RC00127,RC00261,RC00649	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short
SX1_k127_3929315_1	1122931.AUAE01000004_gene3025	3.175e-19	100.0	COG0407@1|root,COG0407@2|Bacteria,4NTJT@976|Bacteroidetes,2FUJS@200643|Bacteroidia,2310U@171551|Porphyromonadaceae	976|Bacteroidetes	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX1_k127_3937743_7	419665.Maeo_1061	1.589e-16	92.0	COG3398@1|root,arCOG02611@2157|Archaea,2XW64@28890|Euryarchaeota,23PZT@183939|Methanococci	183939|Methanococci	K	PFAM regulatory protein, ArsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
SX1_k127_3937743_8	589924.Ferp_0541	9.209e-15	86.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,246Q2@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator, ArsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
SX1_k127_3937743_5	489825.LYNGBM3L_18420	1.274e-45	186.0	COG3344@1|root,COG3344@2|Bacteria,1G1DZ@1117|Cyanobacteria,1H7E3@1150|Oscillatoriales	1117|Cyanobacteria	L	RNA-directed DNA polymerase (Reverse transcriptase)	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	RVT_1
SX1_k127_3937743_2	160799.PBOR_05980	1.711e-63	231.0	COG5621@1|root,COG5621@2|Bacteria,1VE5E@1239|Firmicutes,4HUMD@91061|Bacilli	91061|Bacilli	S	CrtC N-terminal lipocalin domain	-	-	-	-	-	-	-	-	-	-	-	-	CrtC
SX1_k127_3937743_0	1379698.RBG1_1C00001G1511	8.976e-153	496.0	COG0312@1|root,COG0312@2|Bacteria,2NPIS@2323|unclassified Bacteria	2|Bacteria	S	Putative modulator of DNA gyrase	tldD2	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
SX1_k127_3937743_4	515635.Dtur_0187	9.2e-61	227.0	COG0312@1|root,COG0312@2|Bacteria	2|Bacteria	S	metallopeptidase activity	tldE2	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
SX1_k127_3937743_9	1230342.CTM_26342	1.567e-05	53.0	COG0454@1|root,COG0456@2|Bacteria,1V6KU@1239|Firmicutes,24J9Z@186801|Clostridia,36JIM@31979|Clostridiaceae	186801|Clostridia	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10
SX1_k127_3937743_1	1321778.HMPREF1982_00681	1.361e-70	248.0	COG0702@1|root,COG0702@2|Bacteria,1UY7W@1239|Firmicutes,24CSQ@186801|Clostridia	186801|Clostridia	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
SX1_k127_3937743_10	930945.SiRe_1016	2.835e-05	52.0	COG1846@1|root,arCOG03181@2157|Archaea	2157|Archaea	K	Transcriptional regulator MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR
SX1_k127_3937743_3	572546.Arcpr_1852	1.428e-61	218.0	COG1313@1|root,arCOG00934@2157|Archaea,2XUM6@28890|Euryarchaeota,245RV@183980|Archaeoglobi	183980|Archaeoglobi	C	Radical SAM domain protein	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
SX1_k127_3947583_0	269799.Gmet_1507	8.336e-55	208.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,42TQ5@68525|delta/epsilon subdivisions,2WQ0T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SX1_k127_3947583_3	457405.FSDG_02273	3.122e-06	55.0	COG1670@1|root,COG1670@2|Bacteria,37AYB@32066|Fusobacteria	32066|Fusobacteria	J	FR47-like protein	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
SX1_k127_3947583_2	649639.Bcell_3842	8.204e-08	61.0	COG1247@1|root,COG1247@2|Bacteria	2|Bacteria	M	phosphinothricin N-acetyltransferase activity	-	-	2.3.1.183,2.3.1.82	ko:K03823,ko:K18816	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	br01600,ko00000,ko00001,ko01000,ko01504	-	-	-	Acetyltransf_1
SX1_k127_3947583_1	269797.Mbar_A1523	4.786e-16	83.0	COG1339@1|root,arCOG01904@2157|Archaea,2XTFW@28890|Euryarchaeota,2N9NG@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN)	ribK	-	2.7.1.161	ko:K07732	ko00740,ko01100,map00740,map01100	-	R08574	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CTP-dep_RFKase,HTH_24,MarR
SX1_k127_394822_1	523845.AQXV01000055_gene95	3.923e-84	294.0	COG1964@1|root,arCOG00933@2157|Archaea,2XTMK@28890|Euryarchaeota,23QS4@183939|Methanococci	183939|Methanococci	S	PFAM Radical SAM domain protein	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
SX1_k127_394822_4	386456.JQKN01000002_gene2571	1.773e-13	74.0	COG1964@1|root,arCOG00933@2157|Archaea,2XTMK@28890|Euryarchaeota,23NK2@183925|Methanobacteria	183925|Methanobacteria	S	4Fe-4S single cluster domain	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
SX1_k127_394822_2	1121405.dsmv_0900	1.334e-48	181.0	COG3945@1|root,COG3945@2|Bacteria,1N3AR@1224|Proteobacteria,42UWM@68525|delta/epsilon subdivisions,2WQEC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
SX1_k127_394822_5	1347342.BN863_19840	1.169e-12	79.0	COG4299@1|root,COG4299@2|Bacteria,4NDZF@976|Bacteroidetes,1HX1B@117743|Flavobacteriia	976|Bacteroidetes	S	COGs COG4299 conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624,DUF5009
SX1_k127_394822_3	195522.BD01_0445	5.363e-14	83.0	COG0697@1|root,arCOG00272@2157|Archaea,2XZ49@28890|Euryarchaeota,242N7@183968|Thermococci	183968|Thermococci	G	EamA-like transporter family	-	-	-	ko:K03298	-	-	-	-	ko00000,ko02000	2.A.7.3	-	-	EamA
SX1_k127_394822_0	1047013.AQSP01000101_gene607	9.926e-145	466.0	COG1882@1|root,COG1882@2|Bacteria,2NQDK@2323|unclassified Bacteria	2|Bacteria	C	Pyruvate formate lyase-like	pflD	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
SX1_k127_397358_0	1304880.JAGB01000001_gene658	6.839e-52	197.0	COG0412@1|root,COG0412@2|Bacteria,1TQQS@1239|Firmicutes,24DCW@186801|Clostridia	186801|Clostridia	Q	Abhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_7,BAAT_C
SX1_k127_397358_2	269482.Bcep1808_4990	4.949e-20	104.0	COG4409@1|root,COG4409@2|Bacteria,1Q513@1224|Proteobacteria,2WB3C@28216|Betaproteobacteria,1K536@119060|Burkholderiaceae	28216|Betaproteobacteria	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR,BNR_2
SX1_k127_397358_4	405948.SACE_3255	3.822e-07	57.0	COG0640@1|root,COG0640@2|Bacteria,2IQDH@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
SX1_k127_397358_3	522306.CAP2UW1_4094	8.848e-08	59.0	COG1246@1|root,COG1246@2|Bacteria,1NBIV@1224|Proteobacteria,2VX0R@28216|Betaproteobacteria	28216|Betaproteobacteria	E	GCN5-related N-acetyltransferase	-	-	2.3.1.1	ko:K00619	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_7
SX1_k127_397358_1	1121422.AUMW01000013_gene1501	8.786e-44	168.0	COG0500@1|root,COG2226@2|Bacteria,1U5XV@1239|Firmicutes,24A44@186801|Clostridia,260HI@186807|Peptococcaceae	186801|Clostridia	Q	Hypothetical methyltransferase	arsM	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
SX1_k127_3979135_0	338966.Ppro_1776	2.993e-93	316.0	COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,42NRA@68525|delta/epsilon subdivisions,2WJ62@28221|Deltaproteobacteria,43TID@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1	fbp	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0071704,GO:1901135,GO:1901576	3.1.3.11	ko:K03841	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910	M00003,M00165,M00167,M00344	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FBPase
SX1_k127_3979218_2	304371.MCP_2958	1.926e-18	96.0	COG1011@1|root,arCOG02291@2157|Archaea	2157|Archaea	S	hydrolase (HAD superfamily)	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
SX1_k127_3979218_0	1211035.CD30_15015	2.399e-111	372.0	COG0006@1|root,COG0006@2|Bacteria,1TQ6R@1239|Firmicutes,4HA5I@91061|Bacilli,3IVZR@400634|Lysinibacillus	1239|Firmicutes	E	COG0006 Xaa-Pro aminopeptidase	-	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
SX1_k127_3979218_1	998674.ATTE01000001_gene2953	3.729e-39	155.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,45ZXR@72273|Thiotrichales	1236|Gammaproteobacteria	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
SX1_k127_3991539_2	267377.MMP0813	2.832e-12	76.0	arCOG03450@1|root,arCOG03450@2157|Archaea,2XV0N@28890|Euryarchaeota,23QR5@183939|Methanococci	183939|Methanococci	S	PFAM PEGA domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF553
SX1_k127_3991539_0	909663.KI867150_gene266	6.385e-52	195.0	COG4866@1|root,COG4866@2|Bacteria,1RIUZ@1224|Proteobacteria,42P4H@68525|delta/epsilon subdivisions,2WPMI@28221|Deltaproteobacteria,2MRH9@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Uncharacterised conserved protein (DUF2156)	-	-	-	ko:K01163	-	-	-	-	ko00000	-	-	-	DUF2156
SX1_k127_3991539_1	1278078.G419_20545	5.217e-31	127.0	COG3250@1|root,COG3250@2|Bacteria,2I952@201174|Actinobacteria,4FUJ0@85025|Nocardiaceae	201174|Actinobacteria	G	Protein of unknown function (DUF2804)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2804
SX1_k127_4002280_0	56780.SYN_00478	3.526e-73	254.0	COG0388@1|root,COG0388@2|Bacteria,1MX4I@1224|Proteobacteria,42N4T@68525|delta/epsilon subdivisions,2WJK8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,CN_hydrolase
SX1_k127_4002280_1	1365176.N186_06060	2.376e-47	183.0	COG1940@1|root,arCOG04280@2157|Archaea,2XPSQ@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM ROK family protein	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
SX1_k127_4002280_2	585524.HMPREF0493_0468	1.998e-30	140.0	COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,1U5F1@1239|Firmicutes,4IF6M@91061|Bacilli,3F5TQ@33958|Lactobacillaceae	91061|Bacilli	V	DNA restriction-modification system	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_4002280_3	456320.Mvol_1151	1.701e-13	75.0	COG1586@1|root,arCOG00279@2157|Archaea,2XX6W@28890|Euryarchaeota,23QY1@183939|Methanococci	183939|Methanococci	F	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speH	-	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc
SX1_k127_4003621_2	370438.PTH_1510	1.177e-15	86.0	COG1073@1|root,COG1073@2|Bacteria,1UXYN@1239|Firmicutes,24DU6@186801|Clostridia,261XU@186807|Peptococcaceae	186801|Clostridia	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	ko:K06889,ko:K07397	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Hydrolase_4
SX1_k127_4003621_4	710687.KI912270_gene4098	3.526e-06	60.0	COG2267@1|root,COG2267@2|Bacteria,2GPA8@201174|Actinobacteria,232BV@1762|Mycobacteriaceae	201174|Actinobacteria	I	hydrolase	ytpA	GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0010941,GO:0010942,GO:0016020,GO:0016042,GO:0016298,GO:0016787,GO:0016788,GO:0030312,GO:0031341,GO:0031343,GO:0031640,GO:0035821,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043900,GO:0043902,GO:0043903,GO:0044003,GO:0044004,GO:0044068,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044364,GO:0044403,GO:0044419,GO:0044464,GO:0044531,GO:0044532,GO:0044533,GO:0046486,GO:0046503,GO:0047372,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051701,GO:0051704,GO:0051709,GO:0051712,GO:0051817,GO:0051818,GO:0051883,GO:0052040,GO:0052042,GO:0052150,GO:0052151,GO:0052248,GO:0052330,GO:0052433,GO:0052501,GO:0052689,GO:0065007,GO:0071704,GO:0071944,GO:1901575	3.1.1.5	ko:K01048	ko00564,map00564	-	-	-	ko00000,ko00001,ko01000	-	-	-	Hydrolase_4
SX1_k127_4003621_0	1379698.RBG1_1C00001G1027	2.87e-43	164.0	COG0491@1|root,COG0491@2|Bacteria,2NPD5@2323|unclassified Bacteria	2|Bacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SX1_k127_4003621_3	349161.Dred_0517	3.941e-08	66.0	2BCHK@1|root,3263H@2|Bacteria,1US2N@1239|Firmicutes,24YAW@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_4003621_1	1121012.AUKX01000026_gene426	3.376e-18	92.0	COG2366@1|root,COG2366@2|Bacteria,4NEIX@976|Bacteroidetes,1HYJ1@117743|Flavobacteriia,23FVG@178469|Arenibacter	976|Bacteroidetes	S	Penicillin amidase	pac	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
SX1_k127_4004789_1	926560.KE387023_gene2369	2.306e-11	65.0	COG2050@1|root,COG2050@2|Bacteria,1WJVA@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
SX1_k127_4004789_0	439235.Dalk_2037	1.752e-125	410.0	COG0451@1|root,COG0451@2|Bacteria,1P603@1224|Proteobacteria,42NGH@68525|delta/epsilon subdivisions,2WKS6@28221|Deltaproteobacteria,2MI68@213118|Desulfobacterales	28221|Deltaproteobacteria	M	3-beta hydroxysteroid dehydrogenase isomerase	-	-	1.1.1.394,1.1.1.412	ko:K21271,ko:K22320	-	-	-	-	ko00000,ko01000	-	-	-	3Beta_HSD
SX1_k127_4004929_0	1041930.Mtc_1219	7.77e-18	98.0	arCOG01426@1|root,arCOG01426@2157|Archaea	2157|Archaea	-	-	-	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Intein_splicing,Toprim
SX1_k127_4011287_5	930945.SiRe_0233	0.0001163	49.0	COG4352@1|root,arCOG01013@2157|Archaea,2XRIE@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL13 family	rpl13e	-	-	ko:K02873	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13e,Ribosomal_L15e
SX1_k127_4011287_3	33188.XP_002543680.1	1.538e-10	70.0	COG0500@1|root,KOG1331@2759|Eukaryota,38HZD@33154|Opisthokonta,3NVKF@4751|Fungi,3QNFK@4890|Ascomycota,20C3S@147545|Eurotiomycetes,3B1TD@33183|Onygenales	4751|Fungi	Q	tRNA (uracil-5-)-methyltransferase TRM9	TRM9	GO:0000049,GO:0001300,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006417,GO:0006448,GO:0006725,GO:0006807,GO:0007568,GO:0007569,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008198,GO:0009451,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016070,GO:0016300,GO:0016491,GO:0016705,GO:0016706,GO:0016740,GO:0016741,GO:0019222,GO:0030488,GO:0031323,GO:0031326,GO:0032259,GO:0032268,GO:0032502,GO:0034248,GO:0034470,GO:0034641,GO:0034660,GO:0035690,GO:0042221,GO:0042493,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051213,GO:0051246,GO:0051716,GO:0055114,GO:0060255,GO:0065007,GO:0070887,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:2000112	2.1.1.229	ko:K15444	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_11
SX1_k127_4011287_4	1123508.JH636441_gene3652	1.913e-09	66.0	COG0727@1|root,COG0727@2|Bacteria,2IZM1@203682|Planctomycetes	203682|Planctomycetes	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
SX1_k127_4011287_2	243164.DET0533	4.549e-25	113.0	COG1011@1|root,COG1011@2|Bacteria,2G78N@200795|Chloroflexi,34D8N@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
SX1_k127_4011287_1	224719.Abm4_0132	1.926e-32	140.0	COG1035@1|root,arCOG02653@2157|Archaea,2XUJW@28890|Euryarchaeota,23PBF@183925|Methanobacteria	183925|Methanobacteria	C	dehydrogenase, beta subunit	-	-	1.17.1.9	ko:K00125	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer4,FrhB_FdhB_C,FrhB_FdhB_N
SX1_k127_4011287_0	877455.Metbo_1214	1.252e-62	224.0	COG1104@1|root,arCOG00066@2157|Archaea,2Y7J8@28890|Euryarchaeota,23NPK@183925|Methanobacteria	183925|Methanobacteria	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
SX1_k127_4015215_0	349102.Rsph17025_1354	4.702e-12	78.0	COG3378@1|root,COG3378@2|Bacteria,1MV7I@1224|Proteobacteria,2TRS2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Phage plasmid primase P4 family	-	-	-	ko:K06919	-	-	-	-	ko00000	-	-	-	D5_N,Prim-Pol
SX1_k127_4015663_0	926550.CLDAP_11260	3.106e-152	501.0	COG1132@1|root,COG1132@2|Bacteria,2G7QN@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
SX1_k127_4015663_1	357808.RoseRS_2272	4.838e-143	475.0	COG1132@1|root,COG1132@2|Bacteria,2G7J5@200795|Chloroflexi,3758C@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SX1_k127_4015663_7	29176.XP_003883922.1	5.393e-11	75.0	COG1310@1|root,KOG1555@2759|Eukaryota,3Y9VG@5794|Apicomplexa,3YIJG@5796|Coccidia,3YURX@5809|Sarcocystidae	5794|Apicomplexa	O	Prokaryotic homologs of the JAB domain	-	-	-	ko:K03030	ko03050,ko05169,map03050,map05169	M00341	-	-	ko00000,ko00001,ko00002,ko01002,ko03051,ko04121	-	-	-	JAB,MitMem_reg
SX1_k127_4015663_6	926569.ANT_03760	1.71e-11	70.0	COG2018@1|root,COG2018@2|Bacteria,2G8WW@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Roadblock LC7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
SX1_k127_4015663_3	1094980.Mpsy_3091	1.24e-42	168.0	COG2520@1|root,arCOG10124@2157|Archaea,2XTPV@28890|Euryarchaeota,2N953@224756|Methanomicrobia	224756|Methanomicrobia	J	S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe)	taw2	-	2.5.1.114	ko:K07055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Met_10
SX1_k127_4015663_2	572547.Amico_0687	6.574e-65	231.0	COG0330@1|root,COG0330@2|Bacteria,3TAJM@508458|Synergistetes	508458|Synergistetes	O	PFAM band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
SX1_k127_4015663_5	304371.MCP_2904	2.173e-26	117.0	COG0269@1|root,arCOG00103@2157|Archaea,2XUYW@28890|Euryarchaeota,2N9CN@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin	fae-hps	-	4.1.2.43,4.2.1.147	ko:K13812	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05338,R08058	RC00421,RC00422,RC01583,RC01795	ko00000,ko00001,ko00002,ko01000	-	-	-	Fae,OMPdecase
SX1_k127_4015663_4	926569.ANT_22340	2.166e-37	158.0	COG2211@1|root,COG2211@2|Bacteria,2G6RZ@200795|Chloroflexi	200795|Chloroflexi	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX1_k127_4015663_8	694430.Natoc_3739	1.57e-08	58.0	COG0508@1|root,arCOG01706@2157|Archaea,2XUGY@28890|Euryarchaeota,23V33@183963|Halobacteria	183963|Halobacteria	C	COG0508 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	2-oxoacid_dh
SX1_k127_4015964_0	1123376.AUIU01000019_gene1235	2.265e-44	169.0	COG2220@1|root,COG2220@2|Bacteria	2|Bacteria	S	N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
SX1_k127_4015964_2	1415775.U729_709	1.572e-05	57.0	COG3525@1|root,COG3525@2|Bacteria,1TSXM@1239|Firmicutes,248U1@186801|Clostridia,36E3R@31979|Clostridiaceae	186801|Clostridia	G	Glycosyl hydrolase family 20, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,Glyco_hydro_20,Glyco_hydro_20b
SX1_k127_4015964_1	1391646.AVSU01000035_gene2113	3.323e-41	166.0	COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,248HD@186801|Clostridia,25QSU@186804|Peptostreptococcaceae	186801|Clostridia	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
SX1_k127_4016253_8	797304.Natgr_0013	9.145e-05	53.0	COG3428@1|root,arCOG04619@2157|Archaea,2XU23@28890|Euryarchaeota,23T8S@183963|Halobacteria	183963|Halobacteria	S	membrane	-	-	-	ko:K08981	-	-	-	-	ko00000	-	-	-	bPH_2
SX1_k127_4016253_5	5821.PBANKA_141890	1.789e-19	95.0	COG1100@1|root,KOG0087@2759|Eukaryota,3Y9IN@5794|Apicomplexa,3KBXS@422676|Aconoidasida,3YXU2@5819|Haemosporida	422676|Aconoidasida	U	Small GTPase Rab11	-	GO:0000166,GO:0000902,GO:0000904,GO:0001882,GO:0001883,GO:0002790,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005798,GO:0005813,GO:0005815,GO:0005856,GO:0005886,GO:0005929,GO:0006810,GO:0006886,GO:0006887,GO:0006904,GO:0006906,GO:0006996,GO:0007275,GO:0007399,GO:0007409,GO:0008021,GO:0008092,GO:0008104,GO:0008150,GO:0009306,GO:0009653,GO:0009719,GO:0009725,GO:0009894,GO:0009987,GO:0010008,GO:0010033,GO:0010243,GO:0010506,GO:0010646,GO:0012505,GO:0012506,GO:0014069,GO:0015031,GO:0015630,GO:0015833,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017016,GO:0017022,GO:0017076,GO:0017111,GO:0017137,GO:0017157,GO:0019001,GO:0019003,GO:0019222,GO:0019899,GO:0019900,GO:0019901,GO:0022008,GO:0022406,GO:0022607,GO:0023051,GO:0030030,GO:0030031,GO:0030133,GO:0030135,GO:0030136,GO:0030139,GO:0030140,GO:0030141,GO:0030154,GO:0030182,GO:0030425,GO:0030496,GO:0030659,GO:0030667,GO:0031090,GO:0031175,GO:0031267,GO:0031323,GO:0031329,GO:0031410,GO:0031489,GO:0031503,GO:0031982,GO:0032279,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032594,GO:0032868,GO:0032869,GO:0032870,GO:0032879,GO:0032880,GO:0032940,GO:0032989,GO:0032990,GO:0033036,GO:0034613,GO:0035418,GO:0035639,GO:0036064,GO:0036094,GO:0036477,GO:0042221,GO:0042886,GO:0042995,GO:0043005,GO:0043025,GO:0043167,GO:0043168,GO:0043197,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043232,GO:0043434,GO:0044085,GO:0044297,GO:0044309,GO:0044422,GO:0044424,GO:0044430,GO:0044433,GO:0044440,GO:0044441,GO:0044444,GO:0044446,GO:0044456,GO:0044463,GO:0044464,GO:0044782,GO:0045184,GO:0045202,GO:0045335,GO:0046903,GO:0046907,GO:0048167,GO:0048168,GO:0048169,GO:0048193,GO:0048210,GO:0048278,GO:0048284,GO:0048468,GO:0048666,GO:0048667,GO:0048699,GO:0048731,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0050789,GO:0050794,GO:0050804,GO:0050896,GO:0051020,GO:0051046,GO:0051049,GO:0051179,GO:0051223,GO:0051234,GO:0051640,GO:0051641,GO:0051649,GO:0051668,GO:0051716,GO:0055037,GO:0055038,GO:0060271,GO:0060627,GO:0061024,GO:0061025,GO:0061564,GO:0065007,GO:0065008,GO:0070201,GO:0070382,GO:0070727,GO:0070887,GO:0070925,GO:0071310,GO:0071375,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0072659,GO:0090087,GO:0090150,GO:0090174,GO:0097120,GO:0097159,GO:0097367,GO:0097447,GO:0097458,GO:0097546,GO:0097708,GO:0097730,GO:0098588,GO:0098793,GO:0098794,GO:0098805,GO:0098876,GO:0098877,GO:0098969,GO:0098984,GO:0099072,GO:0099177,GO:0099503,GO:0099572,GO:0099632,GO:0099637,GO:0120025,GO:0120031,GO:0120036,GO:0120038,GO:0120039,GO:0140029,GO:0140056,GO:1901265,GO:1901363,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1903530,GO:1903539,GO:1903540,GO:1990778	-	ko:K07904,ko:K07905	ko04144,ko04152,ko04961,ko04962,ko04972,map04144,map04152,map04961,map04962,map04972	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
SX1_k127_4016253_6	313612.L8106_22776	1.029e-06	57.0	COG2189@1|root,COG2189@2|Bacteria,1GAX1@1117|Cyanobacteria	1117|Cyanobacteria	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_4016253_3	1499968.TCA2_4815	4.77e-33	136.0	2D17X@1|root,32TA2@2|Bacteria,1VW5P@1239|Firmicutes,4HWJT@91061|Bacilli,26XV5@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_4016253_4	290402.Cbei_3379	6.697e-33	134.0	COG3760@1|root,COG3760@2|Bacteria,1V1JF@1239|Firmicutes,24FVD@186801|Clostridia,36IUC@31979|Clostridiaceae	186801|Clostridia	S	PFAM YbaK prolyl-tRNA synthetase associated region	proX	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
SX1_k127_4016253_2	313606.M23134_04270	6.24e-51	188.0	COG2129@1|root,COG2129@2|Bacteria,4NNRJ@976|Bacteroidetes,47UN5@768503|Cytophagia	976|Bacteroidetes	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
SX1_k127_4016253_7	272635.MYPU_7400	1.512e-05	56.0	COG0510@1|root,COG0510@2|Bacteria,3WTCY@544448|Tenericutes	544448|Tenericutes	M	PTS system, lichenan-specific IIA component	licA	-	-	-	-	-	-	-	-	-	-	-	APH,Choline_kinase
SX1_k127_4016253_9	1250006.JHZZ01000001_gene2694	0.0004317	43.0	COG2129@1|root,COG2129@2|Bacteria,4NNRJ@976|Bacteroidetes,1I2D7@117743|Flavobacteriia,3VXAM@52959|Polaribacter	976|Bacteroidetes	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
SX1_k127_4016253_0	439235.Dalk_4476	5.417e-144	481.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42PUP@68525|delta/epsilon subdivisions,2WMAH@28221|Deltaproteobacteria,2MN7Y@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
SX1_k127_4016253_1	517418.Ctha_0230	9.227e-62	227.0	COG2706@1|root,COG5184@1|root,COG2706@2|Bacteria,COG5184@2|Bacteria	2|Bacteria	DZ	guanyl-nucleotide exchange factor activity	-	-	-	ko:K12287	-	-	-	-	ko00000,ko02044	-	-	-	Big_5,CHU_C,Cadherin-like,VCBS
SX1_k127_4025727_0	1041930.Mtc_0045	2.35e-12	79.0	arCOG09432@1|root,arCOG09432@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_4025727_1	428125.CLOLEP_03277	0.0003215	45.0	2E3FE@1|root,32YE8@2|Bacteria,1VFR0@1239|Firmicutes,24MNV@186801|Clostridia,3WJTE@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_4038173_1	384616.Pisl_0793	2.221e-18	88.0	COG0846@1|root,arCOG04248@2157|Archaea,2XQBQ@28889|Crenarchaeota	28889|Crenarchaeota	K	form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
SX1_k127_4038173_2	1502851.FG93_01749	6.677e-07	52.0	COG0500@1|root,COG2226@2|Bacteria,1R92P@1224|Proteobacteria,2VEX9@28211|Alphaproteobacteria,3JWE4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
SX1_k127_4038173_3	216596.RL3009	5.002e-06	50.0	COG0500@1|root,COG2226@2|Bacteria,1MV7N@1224|Proteobacteria,2TREK@28211|Alphaproteobacteria,4B89E@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
SX1_k127_4038173_4	1196029.ALIM01000034_gene1760	2.259e-05	49.0	COG0500@1|root,COG2226@2|Bacteria,1TR6N@1239|Firmicutes,4HEMY@91061|Bacilli,1ZRG7@1386|Bacillus	91061|Bacilli	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
SX1_k127_4038173_0	880073.Calab_2894	6.656e-53	207.0	COG2202@1|root,COG5002@1|root,COG2202@2|Bacteria,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	2.7.13.3	ko:K02482,ko:K14986	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF_2,GGDEF,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
SX1_k127_4041812_9	161934.XP_010666458.1	0.0002366	51.0	COG5491@1|root,KOG3230@2759|Eukaryota,37K1A@33090|Viridiplantae,3G8TV@35493|Streptophyta	35493|Streptophyta	U	Belongs to the SNF7 family	-	GO:0000815,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005770,GO:0005771,GO:0006810,GO:0006900,GO:0006996,GO:0007032,GO:0008104,GO:0008150,GO:0009987,GO:0010008,GO:0010256,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0031090,GO:0031410,GO:0031982,GO:0032991,GO:0033036,GO:0036452,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0061024,GO:0070676,GO:0071702,GO:0071705,GO:0071840,GO:0097708,GO:0098588,GO:0098796,GO:0098805	-	ko:K12191	ko04144,ko04217,map04144,map04217	M00412	-	-	ko00000,ko00001,ko00002,ko04131,ko04147	-	-	-	Snf7
SX1_k127_4041812_7	545243.BAEV01000032_gene513	9.097e-12	72.0	COG0394@1|root,COG0394@2|Bacteria,1VA05@1239|Firmicutes,25CRM@186801|Clostridia,36JRD@31979|Clostridiaceae	186801|Clostridia	T	Low molecular weight phosphotyrosine protein phosphatase	ywlE	-	3.1.3.48,3.9.1.2	ko:K01104,ko:K20201	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
SX1_k127_4041812_4	7165.AGAP005460-PA	2.649e-21	99.0	COG0237@1|root,COG1019@1|root,KOG3220@2759|Eukaryota,KOG3351@2759|Eukaryota,38H33@33154|Opisthokonta,3BCJW@33208|Metazoa,3CSPG@33213|Bilateria,41UPE@6656|Arthropoda,3SI0E@50557|Insecta,44XX0@7147|Diptera,45BZ2@7148|Nematocera	33208|Metazoa	H	Dephospho-CoA kinase	COASY	GO:0000003,GO:0001667,GO:0002009,GO:0002064,GO:0002065,GO:0002066,GO:0002165,GO:0003006,GO:0003674,GO:0003824,GO:0004140,GO:0004595,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0005759,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006928,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007297,GO:0007300,GO:0007303,GO:0007444,GO:0007472,GO:0007476,GO:0007552,GO:0007560,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009653,GO:0009791,GO:0009886,GO:0009887,GO:0009888,GO:0009987,GO:0010631,GO:0015936,GO:0015937,GO:0016020,GO:0016301,GO:0016310,GO:0016477,GO:0016482,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019867,GO:0019953,GO:0022412,GO:0022414,GO:0030154,GO:0030707,GO:0030855,GO:0031090,GO:0031966,GO:0031967,GO:0031968,GO:0031974,GO:0031975,GO:0031981,GO:0032501,GO:0032502,GO:0032504,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035107,GO:0035114,GO:0035120,GO:0035220,GO:0035239,GO:0035295,GO:0040011,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0046390,GO:0046483,GO:0046907,GO:0048468,GO:0048477,GO:0048513,GO:0048563,GO:0048569,GO:0048609,GO:0048707,GO:0048729,GO:0048731,GO:0048736,GO:0048737,GO:0048856,GO:0048869,GO:0048870,GO:0048878,GO:0051179,GO:0051186,GO:0051188,GO:0051234,GO:0051641,GO:0051649,GO:0051674,GO:0051704,GO:0055086,GO:0055088,GO:0055090,GO:0060429,GO:0060562,GO:0065007,GO:0065008,GO:0070013,GO:0070328,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090130,GO:0090132,GO:0090407,GO:0098588,GO:0098805,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.24,2.7.7.3	ko:K02318	ko00770,ko01100,map00770,map01100	M00120	R00130,R03035	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like,CoaE
SX1_k127_4041812_1	339860.Msp_0429	1.175e-91	320.0	COG0016@1|root,arCOG00410@2157|Archaea,2XSTK@28890|Euryarchaeota,23NUT@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
SX1_k127_4041812_0	523845.AQXV01000013_gene251	2.691e-120	406.0	COG0072@1|root,arCOG00412@2157|Archaea,2XTD5@28890|Euryarchaeota,23QRD@183939|Methanococci	183939|Methanococci	J	TIGRFAM phenylalanyl-tRNA synthetase, beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,tRNA-synt_2d
SX1_k127_4041812_2	342949.PNA2_0292	7.166e-86	300.0	COG0358@1|root,arCOG04281@2157|Archaea,2XTHB@28890|Euryarchaeota,242MR@183968|Thermococci	183968|Thermococci	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
SX1_k127_4041812_8	1397699.JNIS01000001_gene2970	2.492e-07	63.0	COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,4HB1V@91061|Bacilli	91061|Bacilli	EGP	COG0477 Permeases of the major facilitator superfamily	norA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K19576,ko:K19578	-	M00765	-	-	ko00000,ko00002,ko02000	2.A.1.2.10,2.A.1.2.70	-	-	MFS_1,MFS_1_like,Sugar_tr
SX1_k127_4041812_3	340177.Cag_1412	1.565e-27	125.0	COG0003@1|root,COG0003@2|Bacteria,1FD6J@1090|Chlorobi	1090|Chlorobi	P	TIGRFAM arsenite-activated ATPase ArsA	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
SX1_k127_4041812_5	838561.P344_01060	5.165e-17	84.0	COG0526@1|root,COG0526@2|Bacteria,3WV3W@544448|Tenericutes	544448|Tenericutes	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
SX1_k127_4041812_6	698961.CGSMWGv6119V5_03819	7.179e-16	89.0	COG0526@1|root,COG0526@2|Bacteria,2IKP1@201174|Actinobacteria,4D11J@85004|Bifidobacteriales	201174|Actinobacteria	O	Belongs to the thioredoxin family	trxA	-	1.8.1.9	ko:K00384,ko:K03671	ko00450,ko04621,ko05418,map00450,map04621,map05418	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110	-	-	-	Thioredoxin
SX1_k127_4043395_0	498848.TaqDRAFT_4336	0.0006856	52.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,1WID8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	PFAM Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23
SX1_k127_4043754_0	403833.Pmob_0692	3.342e-36	154.0	COG0477@1|root,COG0477@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	mef	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
SX1_k127_4051320_0	225937.HP15_279	4.291e-05	52.0	2EI3W@1|root,33BVA@2|Bacteria,1NPW4@1224|Proteobacteria,1SGBC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_4053309_0	1289135.A966_13210	1.656e-80	291.0	COG0322@1|root,COG0322@2|Bacteria,2J69M@203691|Spirochaetes	203691|Spirochaetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
SX1_k127_4062523_2	224719.Abm4_1169	3.08e-12	77.0	COG0644@1|root,arCOG00570@2157|Archaea,2XU3J@28890|Euryarchaeota,23PED@183925|Methanobacteria	183925|Methanobacteria	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
SX1_k127_4062523_3	871968.DESME_10070	1.06e-09	62.0	COG2440@1|root,COG2440@2|Bacteria,1V6DH@1239|Firmicutes,252SK@186801|Clostridia,266WX@186807|Peptococcaceae	186801|Clostridia	C	Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S	-	-	-	ko:K03855	-	-	-	-	ko00000	-	-	-	Fer4_9
SX1_k127_4062523_1	1122611.KB903956_gene213	4.882e-51	198.0	COG1233@1|root,COG1233@2|Bacteria	2|Bacteria	Q	all-trans-retinol 13,14-reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
SX1_k127_4062523_0	224325.AF_2411	3.946e-91	313.0	COG2141@1|root,arCOG02410@2157|Archaea,2XV6G@28890|Euryarchaeota,246P8@183980|Archaeoglobi	183980|Archaeoglobi	C	Luciferase-like monooxygenase	-	-	-	ko:K14728	-	-	-	-	ko00000,ko01000	-	-	-	Bac_luciferase
SX1_k127_4062523_4	1173026.Glo7428_2955	0.0004156	47.0	2DKXX@1|root,30TW4@2|Bacteria,1G65F@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_409154_4	267377.MMP1501	5.108e-23	105.0	COG0622@1|root,arCOG01141@2157|Archaea,2XWQ0@28890|Euryarchaeota,23QWI@183939|Methanococci	183939|Methanococci	S	TIGRFAM phosphodiesterase, MJ0936 family	-	GO:0003674,GO:0005488,GO:0008270,GO:0043167,GO:0043169,GO:0046872,GO:0046914	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
SX1_k127_409154_3	909663.KI867150_gene2381	4.089e-27	119.0	COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,42TXX@68525|delta/epsilon subdivisions,2WQBC@28221|Deltaproteobacteria,2MS3T@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	hydrolase of the alpha beta superfamily	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4,Peptidase_S15
SX1_k127_409154_9	436308.Nmar_1656	7.797e-11	67.0	COG0864@1|root,arCOG01008@2157|Archaea,41SQM@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Ribbon-helix-helix protein, copG family	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
SX1_k127_409154_1	693661.Arcve_1623	2.432e-62	224.0	COG0157@1|root,arCOG01482@2157|Archaea,2XTTY@28890|Euryarchaeota,24719@183980|Archaeoglobi	183980|Archaeoglobi	H	Involved in the catabolism of quinolinic acid (QA)	-	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
SX1_k127_409154_7	573063.Metin_1139	4.665e-17	93.0	COG0044@1|root,arCOG00689@2157|Archaea,2XTQU@28890|Euryarchaeota,23Q58@183939|Methanococci	183939|Methanococci	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
SX1_k127_409154_6	180332.JTGN01000002_gene5721	4.082e-19	93.0	COG0044@1|root,COG0044@2|Bacteria,1TPQM@1239|Firmicutes,247V2@186801|Clostridia	186801|Clostridia	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
SX1_k127_409154_0	1183377.Py04_1586	2.362e-140	460.0	COG0541@1|root,arCOG01228@2157|Archaea,2XTWX@28890|Euryarchaeota,24377@183968|Thermococci	183968|Thermococci	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	srp54	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
SX1_k127_409154_5	456320.Mvol_0342	2.558e-20	96.0	COG0231@1|root,arCOG04277@2157|Archaea,2XX3E@28890|Euryarchaeota,23QYU@183939|Methanococci	183939|Methanococci	J	Functions by promoting the formation of the first peptide bond	eIF5A	-	-	ko:K03263	-	-	-	-	ko00000,ko03012	-	-	-	EFP_N,eIF-5a
SX1_k127_409154_2	1094980.Mpsy_2375	6.848e-54	204.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,2NAI6@224756|Methanomicrobia	224756|Methanomicrobia	M	Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
SX1_k127_409154_8	1445613.JALM01000064_gene1344	1.331e-11	77.0	COG5426@1|root,COG5426@2|Bacteria,2GKG4@201174|Actinobacteria	201174|Actinobacteria	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_409154_10	372461.41323037	4.544e-07	54.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,1RMZQ@1236|Gammaproteobacteria,37D93@32199|Buchnera	1236|Gammaproteobacteria	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0000287,GO:0003674,GO:0003824,GO:0003862,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030145,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034198,GO:0042594,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0071496,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1990928	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iECs_1301.ECs0077,iYL1228.KPN_00079,iZ_1308.Z0082	Iso_dh
SX1_k127_4092087_1	234267.Acid_5754	2.184e-31	127.0	COG3324@1|root,COG3324@2|Bacteria,3Y8A9@57723|Acidobacteria	57723|Acidobacteria	S	Glyoxalase-like domain	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	-
SX1_k127_4092087_2	1056495.Calag_1291	3.804e-28	129.0	COG0644@1|root,arCOG00570@2157|Archaea,2XPWV@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM geranylgeranyl reductase	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2,FAD_binding_3,FAD_oxidored,Trp_halogenase
SX1_k127_4092087_3	243164.DET1392	3.21e-19	93.0	COG0607@1|root,COG0607@2|Bacteria,2G71Z@200795|Chloroflexi,34DDK@301297|Dehalococcoidia	301297|Dehalococcoidia	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
SX1_k127_4092087_0	935948.KE386494_gene944	2.423e-133	436.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,42EKB@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM aminotransferase, class I	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
SX1_k127_4094668_0	309803.CTN_1411	6.759e-133	434.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GC9M@200918|Thermotogae	200918|Thermotogae	C	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1164	POR,POR_N
SX1_k127_4094668_2	1499967.BAYZ01000160_gene414	1.236e-77	274.0	COG1524@1|root,COG1524@2|Bacteria,2NQ0M@2323|unclassified Bacteria	2|Bacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
SX1_k127_4094668_9	1408303.JNJJ01000078_gene1182	3.966e-06	57.0	COG2020@1|root,COG2020@2|Bacteria,1UXZ3@1239|Firmicutes	1239|Firmicutes	O	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
SX1_k127_4094668_6	203119.Cthe_2382	8.199e-23	113.0	COG0477@1|root,COG2814@2|Bacteria,1UZSN@1239|Firmicutes,249EU@186801|Clostridia	186801|Clostridia	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX1_k127_4094668_1	391623.TERMP_01434	6.991e-103	343.0	COG0540@1|root,arCOG00911@2157|Archaea,2XSZ7@28890|Euryarchaeota,242WA@183968|Thermococci	183968|Thermococci	F	Aspartate carbamoyltransferase	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
SX1_k127_4094668_5	768679.TTX_0575	3.942e-23	101.0	COG1631@1|root,arCOG04109@2157|Archaea,2XQU0@28889|Crenarchaeota	28889|Crenarchaeota	J	binds to the 23S rRNA	rpl44e	-	-	ko:K02929	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L44
SX1_k127_4094668_8	523845.AQXV01000050_gene989	1.568e-14	75.0	COG2051@1|root,arCOG04108@2157|Archaea,2XZW2@28890|Euryarchaeota,23R97@183939|Methanococci	183939|Methanococci	J	PFAM Ribosomal protein S27E	rps27e	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02978	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S27e
SX1_k127_4094668_7	765177.Desmu_0043	1.984e-19	91.0	COG1594@1|root,arCOG00579@2157|Archaea,2XQQ6@28889|Crenarchaeota	28889|Crenarchaeota	K	Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family	tfs	GO:0003674,GO:0005488,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	RNA_POL_M_15KD,TFIIS_C
SX1_k127_4094668_3	8364.ENSXETP00000017963	4.346e-30	129.0	COG0592@1|root,KOG1636@2759|Eukaryota,38MVP@33154|Opisthokonta,3BGUR@33208|Metazoa,3CTAW@33213|Bilateria,4800U@7711|Chordata,48Z1K@7742|Vertebrata	33208|Metazoa	L	dinucleotide insertion or deletion binding	PCNA	GO:0000003,GO:0000075,GO:0000077,GO:0000082,GO:0000083,GO:0000122,GO:0000226,GO:0000228,GO:0000278,GO:0000302,GO:0000307,GO:0000700,GO:0000701,GO:0000723,GO:0000731,GO:0001101,GO:0001889,GO:0002064,GO:0002065,GO:0002066,GO:0002376,GO:0003006,GO:0003674,GO:0003676,GO:0003677,GO:0003682,GO:0003684,GO:0003690,GO:0003824,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005652,GO:0005654,GO:0005657,GO:0005663,GO:0005694,GO:0005813,GO:0005815,GO:0005856,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006272,GO:0006275,GO:0006277,GO:0006281,GO:0006282,GO:0006283,GO:0006284,GO:0006287,GO:0006289,GO:0006296,GO:0006297,GO:0006298,GO:0006301,GO:0006355,GO:0006357,GO:0006464,GO:0006725,GO:0006807,GO:0006950,GO:0006955,GO:0006959,GO:0006974,GO:0006977,GO:0006979,GO:0006996,GO:0007010,GO:0007017,GO:0007049,GO:0007051,GO:0007052,GO:0007093,GO:0007154,GO:0007165,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007304,GO:0007306,GO:0007307,GO:0007346,GO:0007507,GO:0007584,GO:0008134,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009059,GO:0009314,GO:0009410,GO:0009411,GO:0009416,GO:0009605,GO:0009607,GO:0009617,GO:0009628,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009888,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010035,GO:0010038,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010564,GO:0010604,GO:0010605,GO:0010629,GO:0010927,GO:0010948,GO:0014070,GO:0014823,GO:0015630,GO:0016043,GO:0016070,GO:0016567,GO:0016604,GO:0016787,GO:0016798,GO:0016799,GO:0018130,GO:0019104,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0019725,GO:0019730,GO:0019899,GO:0019900,GO:0019901,GO:0019953,GO:0019985,GO:0022402,GO:0022412,GO:0022414,GO:0022607,GO:0022616,GO:0023052,GO:0030154,GO:0030234,GO:0030330,GO:0030331,GO:0030337,GO:0030703,GO:0030707,GO:0030855,GO:0030894,GO:0030971,GO:0030983,GO:0031099,GO:0031100,GO:0031297,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031570,GO:0031571,GO:0031667,GO:0031960,GO:0031974,GO:0031981,GO:0032069,GO:0032070,GO:0032075,GO:0032077,GO:0032135,GO:0032139,GO:0032200,GO:0032201,GO:0032355,GO:0032404,GO:0032405,GO:0032446,GO:0032501,GO:0032502,GO:0032504,GO:0032989,GO:0032991,GO:0032993,GO:0033260,GO:0033554,GO:0033683,GO:0033993,GO:0034399,GO:0034599,GO:0034614,GO:0034641,GO:0034644,GO:0034645,GO:0034654,GO:0035035,GO:0035257,GO:0035258,GO:0035556,GO:0035690,GO:0036211,GO:0042221,GO:0042276,GO:0042493,GO:0042542,GO:0042592,GO:0042698,GO:0042769,GO:0042770,GO:0042802,GO:0043085,GO:0043170,GO:0043200,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043596,GO:0043626,GO:0043933,GO:0044085,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044430,GO:0044446,GO:0044451,GO:0044454,GO:0044464,GO:0044703,GO:0044770,GO:0044772,GO:0044773,GO:0044774,GO:0044783,GO:0044786,GO:0044796,GO:0044819,GO:0044843,GO:0044849,GO:0044877,GO:0045005,GO:0045739,GO:0045740,GO:0045786,GO:0045787,GO:0045892,GO:0045930,GO:0045934,GO:0045935,GO:0046483,GO:0046677,GO:0046686,GO:0048468,GO:0048477,GO:0048511,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048545,GO:0048583,GO:0048584,GO:0048609,GO:0048646,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051259,GO:0051260,GO:0051276,GO:0051336,GO:0051345,GO:0051384,GO:0051427,GO:0051606,GO:0051704,GO:0051707,GO:0051716,GO:0051726,GO:0060249,GO:0060255,GO:0060429,GO:0061008,GO:0061695,GO:0065003,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070182,GO:0070206,GO:0070207,GO:0070301,GO:0070557,GO:0070647,GO:0070887,GO:0070987,GO:0071156,GO:0071158,GO:0071214,GO:0071236,GO:0071466,GO:0071478,GO:0071482,GO:0071548,GO:0071704,GO:0071840,GO:0071897,GO:0072331,GO:0072359,GO:0072395,GO:0072401,GO:0072413,GO:0072422,GO:0072431,GO:0080090,GO:0080134,GO:0080135,GO:0090068,GO:0090304,GO:0090305,GO:0097159,GO:0097237,GO:0097327,GO:0097421,GO:0098772,GO:0104004,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901576,GO:1901654,GO:1901698,GO:1901700,GO:1901701,GO:1901987,GO:1901988,GO:1901990,GO:1901991,GO:1902065,GO:1902400,GO:1902402,GO:1902403,GO:1902494,GO:1902554,GO:1902679,GO:1902806,GO:1902807,GO:1902850,GO:1902911,GO:1902990,GO:1903047,GO:1903506,GO:1903507,GO:1990234,GO:1990782,GO:2000045,GO:2000112,GO:2000113,GO:2000134,GO:2001020,GO:2001022,GO:2001141	-	ko:K04802	ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166	M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	PCNA_C,PCNA_N
SX1_k127_4094668_4	694429.Pyrfu_1715	6.725e-28	127.0	COG2219@1|root,arCOG03013@2157|Archaea,2XQ8M@28889|Crenarchaeota	28889|Crenarchaeota	L	Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priL	-	-	ko:K18882	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_lrg
SX1_k127_4095522_2	1307761.L21SP2_0399	3.367e-40	154.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX1_k127_4095522_1	1042877.GQS_08850	5.214e-67	245.0	COG0477@1|root,arCOG00130@2157|Archaea,2XUHI@28890|Euryarchaeota,243TD@183968|Thermococci	183968|Thermococci	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX1_k127_4095522_3	1459636.NTE_02686	0.0001924	46.0	arCOG08817@1|root,arCOG08817@2157|Archaea,41SV5@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_4095522_0	429009.Adeg_1192	4.691e-115	379.0	COG1064@1|root,COG1064@2|Bacteria,1TP5B@1239|Firmicutes,24GKF@186801|Clostridia,42HT2@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM zinc-binding alcohol dehydrogenase family protein	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
SX1_k127_4102581_0	1056495.Calag_0836	3.524e-49	188.0	COG0028@1|root,arCOG01998@2157|Archaea,2XPT4@28889|Crenarchaeota	2157|Archaea	E	TPP binding domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
SX1_k127_4105176_2	880073.Calab_3232	1.761e-250	779.0	COG0031@1|root,COG0031@2|Bacteria,2NNZI@2323|unclassified Bacteria	2|Bacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47,6.2.1.30	ko:K01738,ko:K01912	ko00270,ko00360,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko05111,map00270,map00360,map00920,map01100,map01110,map01120,map01130,map01200,map01230,map05111	M00021	R00897,R02539,R03601,R04859	RC00004,RC00014,RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SX1_k127_4105176_3	880073.Calab_3233	6.804e-175	561.0	COG0044@1|root,COG0044@2|Bacteria,2NNWP@2323|unclassified Bacteria	2|Bacteria	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pucH	-	3.5.2.2,3.5.2.5	ko:K01464,ko:K01466	ko00230,ko00240,ko00410,ko00770,ko00983,ko01100,ko01120,map00230,map00240,map00410,map00770,map00983,map01100,map01120	M00046,M00546	R02269,R02425,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
SX1_k127_4105176_4	880073.Calab_3234	2.151e-146	477.0	COG0402@1|root,COG0402@2|Bacteria,2NQKF@2323|unclassified Bacteria	2|Bacteria	F	Amidohydrolase family	ssnA	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
SX1_k127_4105176_1	880073.Calab_3235	0.0	1090.0	COG1529@1|root,COG1529@2|Bacteria,2NNTR@2323|unclassified Bacteria	2|Bacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	MA20_13970	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,CO_deh_flav_C,FAD_binding_5
SX1_k127_4105176_7	880073.Calab_3236	5.034e-90	304.0	COG1319@1|root,COG1319@2|Bacteria,2NQ9S@2323|unclassified Bacteria	2|Bacteria	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.17.1.4,1.17.1.5,1.2.5.3	ko:K03519,ko:K13479,ko:K20445	ko00230,ko00760,ko01100,ko01120,map00230,map00760,map01100,map01120	M00546	R01720,R01768,R02103,R11168	RC00143,RC00589,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,CO_deh_flav_C,FAD_binding_5
SX1_k127_4105176_9	880073.Calab_3237	2.179e-58	207.0	COG2080@1|root,COG2080@2|Bacteria,2NPPX@2323|unclassified Bacteria	2|Bacteria	C	PFAM 2Fe-2S -binding	ndhS	-	1.17.1.5,1.2.5.3,1.3.99.16	ko:K03518,ko:K07302,ko:K13483,ko:K20446	ko00230,ko00760,ko01100,ko01120,map00230,map00760,map01100,map01120	M00546	R01720,R01768,R02103,R11168	RC00143,RC00589,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Fer2_2
SX1_k127_4105176_0	880073.Calab_3239	0.0	1106.0	COG0493@1|root,COG1145@1|root,COG0493@2|Bacteria,COG1145@2|Bacteria,2NQCY@2323|unclassified Bacteria	2|Bacteria	CE	FAD binding domain	ygfK	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0055114	1.97.1.9	ko:K12527	ko00450,map00450	-	R07229	RC02420	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Fer4_7,GXGXG,Pyr_redox_2,Pyr_redox_3
SX1_k127_4105176_5	443254.Marpi_1705	9.323e-142	460.0	COG0624@1|root,COG0624@2|Bacteria,2GCN7@200918|Thermotogae	200918|Thermotogae	E	peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
SX1_k127_4105176_6	403833.Pmob_1731	2.401e-138	447.0	COG0078@1|root,COG0078@2|Bacteria,2GCNA@200918|Thermotogae	200918|Thermotogae	E	aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain	-	-	-	-	-	-	-	-	-	-	-	-	OTCace,OTCace_N
SX1_k127_4105176_8	880073.Calab_3231	1.601e-87	297.0	COG0498@1|root,COG0498@2|Bacteria,2NP42@2323|unclassified Bacteria	2|Bacteria	E	Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SX1_k127_4114606_0	386456.JQKN01000001_gene2034	1.054e-118	407.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,23NMS@183925|Methanobacteria	183925|Methanobacteria	K	Domain of unknown function (DUF814)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
SX1_k127_4114606_1	171693.BN988_01039	1.766e-19	98.0	COG1233@1|root,COG1233@2|Bacteria,1TS4A@1239|Firmicutes,4HB9J@91061|Bacilli,23IKV@182709|Oceanobacillus	91061|Bacilli	Q	Flavin containing amine oxidoreductase	crtN	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase,NAD_binding_8
SX1_k127_4118766_2	368408.Tpen_0923	8.278e-43	169.0	COG0037@1|root,arCOG00042@2157|Archaea,2XQ4Q@28889|Crenarchaeota	28889|Crenarchaeota	D	PFAM PP-loop domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ATP_bind_3
SX1_k127_4118766_6	29760.VIT_08s0007g00720.t01	8.123e-05	52.0	KOG0800@1|root,KOG0800@2759|Eukaryota,37NKN@33090|Viridiplantae,3GD8C@35493|Streptophyta	35493|Streptophyta	O	E3 ubiquitin-protein ligase RING1-like	-	-	2.3.2.27	ko:K11982	-	-	-	-	ko00000,ko01000,ko04121,ko04131	-	-	-	DUF1117,zf-RING_2,zinc_ribbon_9
SX1_k127_4118766_0	415426.Hbut_0632	3.945e-66	232.0	COG2518@1|root,arCOG00976@2157|Archaea,2XPYU@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
SX1_k127_4118766_3	56780.SYN_02874	1.736e-38	157.0	COG0524@1|root,COG0524@2|Bacteria,1MUUC@1224|Proteobacteria,42M1U@68525|delta/epsilon subdivisions,2WKK5@28221|Deltaproteobacteria,2MRYB@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	pfkB family carbohydrate kinase	-	-	2.7.1.15,2.7.1.4	ko:K00847,ko:K00852	ko00030,ko00051,ko00500,ko00520,ko01100,map00030,map00051,map00500,map00520,map01100	-	R00760,R00867,R01051,R02750,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
SX1_k127_4118766_5	224719.Abm4_1694	2.015e-27	130.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTJP@28890|Euryarchaeota,23NX4@183925|Methanobacteria	183925|Methanobacteria	L	Replication factor-A C terminal domain	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	CDC24_OB3,Rep_fac-A_C,tRNA_anti-codon
SX1_k127_4118766_1	573064.Mefer_0778	4.233e-46	175.0	COG1891@1|root,arCOG04482@2157|Archaea,2XUBQ@28890|Euryarchaeota,23QQH@183939|Methanococci	183939|Methanococci	H	Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P)	mfnB	-	4.2.3.153	ko:K09733	ko00680,map00680	-	R10935	RC03315	ko00000,ko00001,ko01000	-	-	-	4HFCP_synth
SX1_k127_4118766_4	671143.DAMO_2656	1.018e-34	142.0	COG1411@1|root,COG1411@2|Bacteria	2|Bacteria	C	Belongs to the HisA HisF family	-	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
SX1_k127_4147089_5	768706.Desor_0579	6.93e-29	120.0	COG2516@1|root,COG2516@2|Bacteria,1TQF6@1239|Firmicutes,24AAS@186801|Clostridia,263Y3@186807|Peptococcaceae	186801|Clostridia	S	PFAM Radical SAM superfamily	-	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
SX1_k127_4147089_3	592015.HMPREF1705_00648	2.239e-47	180.0	COG0095@1|root,COG0095@2|Bacteria,3TBDG@508458|Synergistetes	508458|Synergistetes	H	PFAM Biotin lipoate A B protein ligase family	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
SX1_k127_4147089_2	521045.Kole_0475	7.249e-51	193.0	COG1856@1|root,COG1856@2|Bacteria,2GD21@200918|Thermotogae	200918|Thermotogae	S	PFAM Radical SAM domain protein	-	-	-	ko:K09711	-	-	-	-	ko00000	-	-	-	Radical_SAM
SX1_k127_4147089_0	1459636.NTE_00007	4.047e-122	423.0	COG0417@1|root,arCOG00329@2157|Archaea	2157|Archaea	L	DNA polymerase elongation subunit (Family B)	polB2	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B
SX1_k127_4147089_7	1227495.C487_17360	4.842e-09	61.0	arCOG07300@1|root,arCOG07300@2157|Archaea,2XXYB@28890|Euryarchaeota,23WG9@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_4147089_8	5297.GMQ_03140T0	2.216e-08	66.0	COG0468@1|root,KOG1434@2759|Eukaryota,39J83@33154|Opisthokonta,3NVB0@4751|Fungi,3UY0V@5204|Basidiomycota,2YFIG@29000|Pucciniomycotina	4751|Fungi	L	KaiC	-	GO:0000003,GO:0000018,GO:0000150,GO:0000166,GO:0000217,GO:0000228,GO:0000280,GO:0000400,GO:0000709,GO:0000724,GO:0000725,GO:0000730,GO:0000793,GO:0000794,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006311,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007059,GO:0007127,GO:0007129,GO:0007130,GO:0007131,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010520,GO:0010564,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022402,GO:0022414,GO:0022607,GO:0030554,GO:0031323,GO:0031974,GO:0031981,GO:0032553,GO:0032555,GO:0032559,GO:0033043,GO:0033554,GO:0034622,GO:0034641,GO:0035639,GO:0035822,GO:0035825,GO:0036094,GO:0040020,GO:0042148,GO:0042623,GO:0042802,GO:0043142,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0044877,GO:0045003,GO:0045132,GO:0045143,GO:0046483,GO:0048285,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051128,GO:0051171,GO:0051259,GO:0051260,GO:0051276,GO:0051321,GO:0051445,GO:0051716,GO:0051726,GO:0051783,GO:0060255,GO:0060631,GO:0061982,GO:0065003,GO:0065004,GO:0065007,GO:0070013,GO:0070192,GO:0070193,GO:0071704,GO:0071824,GO:0071840,GO:0080090,GO:0090304,GO:0090735,GO:0097159,GO:0097367,GO:0098813,GO:0140013,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1903046,GO:1905334,GO:2000241	-	ko:K10872,ko:K14545	ko03008,ko04113,map03008,map04113	-	-	-	ko00000,ko00001,ko03009,ko03400	-	-	-	HHH_5,Rad51
SX1_k127_4147089_6	224324.aq_1847	2.064e-09	64.0	COG2018@1|root,COG2018@2|Bacteria,2G4D2@200783|Aquificae	200783|Aquificae	S	PFAM Roadblock LC7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
SX1_k127_4147089_1	579137.Metvu_0532	5.894e-81	288.0	COG3276@1|root,arCOG01564@2157|Archaea,2Y862@28890|Euryarchaeota,23QEK@183939|Methanococci	183939|Methanococci	J	elongation factor Tu domain 2 protein	selB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2
SX1_k127_4147089_4	1535422.ND16A_1305	3.855e-33	138.0	COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,1SA4Q@1236|Gammaproteobacteria,2Q71R@267889|Colwelliaceae	1236|Gammaproteobacteria	L	NUDIX domain	nudL	GO:0003674,GO:0003824,GO:0016787,GO:0016817,GO:0016818	-	-	-	-	-	-	-	-	-	-	DUF1289,NUDIX
SX1_k127_4152820_1	1144275.COCOR_01923	7.921e-08	57.0	COG2319@1|root,COG2319@2|Bacteria,1MWJA@1224|Proteobacteria,42P8D@68525|delta/epsilon subdivisions,2WMH1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	WD40
SX1_k127_4152820_2	1168289.AJKI01000015_gene2141	8.166e-06	53.0	2E991@1|root,333HB@2|Bacteria,4NZDJ@976|Bacteroidetes,2G1CW@200643|Bacteroidia,3XKV1@558415|Marinilabiliaceae	976|Bacteroidetes	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
SX1_k127_4152820_0	673860.AciM339_1288	1.804e-20	106.0	arCOG02499@1|root,arCOG02499@2157|Archaea,2Y6YI@28890|Euryarchaeota,3F2WY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	NosD
SX1_k127_4156379_0	123214.PERMA_0937	1.315e-07	59.0	COG3291@1|root,COG3291@2|Bacteria,2G57S@200783|Aquificae	200783|Aquificae	O	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
SX1_k127_4162876_0	398512.JQKC01000017_gene3112	1.333e-09	69.0	COG0457@1|root,COG0457@2|Bacteria	398512.JQKC01000017_gene3112|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_4170015_10	1387312.BAUS01000002_gene256	1.998e-09	65.0	COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,2VHCH@28216|Betaproteobacteria,2KKEF@206350|Nitrosomonadales	206350|Nitrosomonadales	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
SX1_k127_4170015_9	573063.Metin_0746	1.316e-17	91.0	COG2890@1|root,arCOG00109@2157|Archaea,2XWJZ@28890|Euryarchaeota,23QUN@183939|Methanococci	183939|Methanococci	J	PFAM methyltransferase small	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044464	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,PrmA
SX1_k127_4170015_8	742743.HMPREF9453_01193	2.164e-20	96.0	COG3118@1|root,COG3118@2|Bacteria,1VA3Y@1239|Firmicutes,4H5KC@909932|Negativicutes	909932|Negativicutes	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
SX1_k127_4170015_3	877455.Metbo_0191	1.873e-35	147.0	COG0030@1|root,arCOG04131@2157|Archaea,2XU1Q@28890|Euryarchaeota,23NYN@183925|Methanobacteria	183925|Methanobacteria	J	Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
SX1_k127_4170015_4	1041930.Mtc_2250	1.668e-34	142.0	COG1491@1|root,arCOG04130@2157|Archaea,2XXAI@28890|Euryarchaeota,2N9MM@224756|Methanomicrobia	224756|Methanomicrobia	J	Protein of unknown function (DUF655)	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
SX1_k127_4170015_12	397948.Cmaq_1982	6.424e-05	50.0	COG1460@1|root,arCOG01016@2157|Archaea,2XRD2@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM RNA polymerase Rpb4	rpoF	-	2.7.7.6	ko:K03051	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb4
SX1_k127_4170015_7	1054217.TALC_01427	6.974e-21	96.0	COG2139@1|root,arCOG04129@2157|Archaea,2XXZB@28890|Euryarchaeota,241X7@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the eukaryotic ribosomal protein eL21 family	rpl21e	-	-	ko:K02889	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21e
SX1_k127_4170015_1	269797.Mbar_A3230	1.331e-85	301.0	COG1258@1|root,arCOG01015@2157|Archaea,2XTTX@28890|Euryarchaeota,2N98Y@224756|Methanomicrobia	224756|Methanomicrobia	J	Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs	pus10	-	5.4.99.25	ko:K07583	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP
SX1_k127_4170015_13	1121936.AUHI01000012_gene1204	0.0007542	50.0	COG1428@1|root,COG1428@2|Bacteria,1TQKS@1239|Firmicutes,4HBWC@91061|Bacilli	91061|Bacilli	F	deoxyguanosine kinase	dgk	-	2.7.1.113	ko:K15518	ko00230,map00230	-	R01967	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	dNK
SX1_k127_4170015_0	755731.Clo1100_1733	1.64e-187	600.0	COG3033@1|root,COG3033@2|Bacteria,1TRGV@1239|Firmicutes,248WC@186801|Clostridia,36G6C@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the beta-eliminating lyase family	tnaA	-	4.1.99.1	ko:K01667	ko00380,map00380	-	R00673	RC00209,RC00355	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
SX1_k127_4170015_2	579137.Metvu_0910	1.366e-60	224.0	COG1465@1|root,arCOG04353@2157|Archaea,2XSXD@28890|Euryarchaeota,23QQQ@183939|Methanococci	183939|Methanococci	E	Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis	aroB'	-	1.4.1.24	ko:K11646	ko00400,ko01110,ko01130,map00400,map01110,map01130	-	R08569	RC02302	ko00000,ko00001,ko01000	-	-	-	DHQS
SX1_k127_4170015_6	644283.Micau_5046	2.368e-24	117.0	COG0477@1|root,COG2814@2|Bacteria,2IDJ6@201174|Actinobacteria,4D9HF@85008|Micromonosporales	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX1_k127_4170015_11	326427.Cagg_3625	1.295e-06	60.0	COG2018@1|root,COG2018@2|Bacteria,2G8WW@200795|Chloroflexi,375M5@32061|Chloroflexia	32061|Chloroflexia	S	PFAM Roadblock LC7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
SX1_k127_4170015_5	484019.THA_1573	3.202e-26	111.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,2GCDP@200918|Thermotogae	200918|Thermotogae	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
SX1_k127_4201993_1	756272.Plabr_1640	1.831e-81	282.0	COG1626@1|root,COG1626@2|Bacteria	2|Bacteria	G	alpha,alpha-trehalase activity	treA	GO:0003674,GO:0003824,GO:0004553,GO:0004555,GO:0005575,GO:0005623,GO:0005975,GO:0005984,GO:0005991,GO:0005993,GO:0006950,GO:0006970,GO:0006972,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009628,GO:0009987,GO:0015926,GO:0015927,GO:0016052,GO:0016787,GO:0016798,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0042597,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044464,GO:0046352,GO:0050896,GO:0051716,GO:0071214,GO:0071470,GO:0071474,GO:0071704,GO:0104004,GO:1901575	3.2.1.28	ko:K01194,ko:K03931	ko00500,ko01100,map00500,map01100	-	R00010	RC00049	ko00000,ko00001,ko00537,ko01000	-	GH37,GH63	iAF1260.b1197,iB21_1397.B21_01182,iBWG_1329.BWG_1022,iECBD_1354.ECBD_2425,iECB_1328.ECB_01172,iECDH10B_1368.ECDH10B_1250,iECDH1ME8569_1439.ECDH1ME8569_1136,iECD_1391.ECD_01172,iECUMN_1333.ECUMN_1493,iETEC_1333.ETEC_1301,iEcDH1_1363.EcDH1_2451,iEcHS_1320.EcHS_A1301,iEcolC_1368.EcolC_2429,iJO1366.b1197,iJR904.b1197,iSBO_1134.SBO_3518,iY75_1357.Y75_RS06245	Glyco_hydro_63,Trehalase
SX1_k127_4201993_0	1121405.dsmv_0775	3.632e-114	383.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_4,Sugar_tr
SX1_k127_4201993_3	397948.Cmaq_1206	1.9e-20	100.0	COG2101@1|root,arCOG01764@2157|Archaea,2XQ5U@28889|Crenarchaeota	28889|Crenarchaeota	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	tbp	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
SX1_k127_4201993_2	45157.CMF181CT	3.404e-29	129.0	KOG0084@1|root,KOG0084@2759|Eukaryota	2759|Eukaryota	S	GTPase activity	RAB1A	GO:0000003,GO:0000045,GO:0000139,GO:0000149,GO:0000166,GO:0000278,GO:0000280,GO:0000281,GO:0000407,GO:0000902,GO:0000904,GO:0000910,GO:0001816,GO:0001882,GO:0001883,GO:0002790,GO:0002791,GO:0002793,GO:0003006,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005768,GO:0005769,GO:0005773,GO:0005783,GO:0005789,GO:0005793,GO:0005794,GO:0005795,GO:0005801,GO:0005802,GO:0005829,GO:0005886,GO:0005911,GO:0006139,GO:0006401,GO:0006464,GO:0006725,GO:0006807,GO:0006810,GO:0006886,GO:0006888,GO:0006890,GO:0006897,GO:0006900,GO:0006901,GO:0006903,GO:0006906,GO:0006914,GO:0006928,GO:0006950,GO:0006952,GO:0006996,GO:0007017,GO:0007018,GO:0007030,GO:0007033,GO:0007049,GO:0007112,GO:0007140,GO:0007154,GO:0007155,GO:0007165,GO:0007264,GO:0007265,GO:0007267,GO:0007275,GO:0007276,GO:0007399,GO:0008088,GO:0008089,GO:0008092,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009306,GO:0009506,GO:0009555,GO:0009605,GO:0009607,GO:0009617,GO:0009653,GO:0009826,GO:0009856,GO:0009860,GO:0009893,GO:0009894,GO:0009914,GO:0009932,GO:0009966,GO:0009987,GO:0010035,GO:0010038,GO:0010256,GO:0010506,GO:0010604,GO:0010646,GO:0010647,GO:0010720,GO:0010769,GO:0010770,GO:0010817,GO:0010970,GO:0010975,GO:0010976,GO:0012505,GO:0012506,GO:0015031,GO:0015833,GO:0016020,GO:0016032,GO:0016043,GO:0016049,GO:0016050,GO:0016070,GO:0016192,GO:0016197,GO:0016236,GO:0016241,GO:0016462,GO:0016477,GO:0016482,GO:0016787,GO:0016817,GO:0016818,GO:0017022,GO:0017076,GO:0017111,GO:0019001,GO:0019058,GO:0019068,GO:0019220,GO:0019222,GO:0019439,GO:0019538,GO:0019953,GO:0022008,GO:0022402,GO:0022406,GO:0022411,GO:0022412,GO:0022414,GO:0022603,GO:0022604,GO:0022607,GO:0022610,GO:0023051,GO:0023052,GO:0023056,GO:0023061,GO:0030054,GO:0030072,GO:0030133,GO:0030154,GO:0030252,GO:0030334,GO:0030658,GO:0030659,GO:0030705,GO:0030742,GO:0031090,GO:0031323,GO:0031325,GO:0031329,GO:0031344,GO:0031346,GO:0031396,GO:0031398,GO:0031399,GO:0031401,GO:0031410,GO:0031589,GO:0031982,GO:0031984,GO:0032024,GO:0032029,GO:0032036,GO:0032153,GO:0032154,GO:0032155,GO:0032258,GO:0032268,GO:0032270,GO:0032400,GO:0032401,GO:0032402,GO:0032456,GO:0032482,GO:0032501,GO:0032502,GO:0032504,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032588,GO:0032637,GO:0032879,GO:0032880,GO:0032940,GO:0032984,GO:0032989,GO:0033036,GO:0033043,GO:0033059,GO:0033116,GO:0033206,GO:0033365,GO:0033500,GO:0034045,GO:0034067,GO:0034446,GO:0034497,GO:0034498,GO:0034613,GO:0034622,GO:0034641,GO:0034655,GO:0035459,GO:0035493,GO:0035494,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0036477,GO:0040007,GO:0040011,GO:0040012,GO:0042147,GO:0042175,GO:0042221,GO:0042325,GO:0042470,GO:0042592,GO:0042742,GO:0042886,GO:0043025,GO:0043085,GO:0043167,GO:0043168,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043473,GO:0043549,GO:0043624,GO:0043687,GO:0043933,GO:0044085,GO:0044087,GO:0044088,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044297,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044432,GO:0044433,GO:0044444,GO:0044446,GO:0044456,GO:0044459,GO:0044464,GO:0044703,GO:0044706,GO:0045184,GO:0045202,GO:0045595,GO:0045597,GO:0045664,GO:0045666,GO:0046483,GO:0046686,GO:0046700,GO:0046879,GO:0046883,GO:0046887,GO:0046903,GO:0046907,GO:0047496,GO:0048193,GO:0048194,GO:0048199,GO:0048207,GO:0048208,GO:0048211,GO:0048229,GO:0048232,GO:0048278,GO:0048284,GO:0048285,GO:0048468,GO:0048518,GO:0048522,GO:0048583,GO:0048588,GO:0048589,GO:0048609,GO:0048699,GO:0048731,GO:0048770,GO:0048814,GO:0048856,GO:0048868,GO:0048869,GO:0048870,GO:0048878,GO:0050663,GO:0050708,GO:0050714,GO:0050767,GO:0050769,GO:0050773,GO:0050775,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050796,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051094,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051222,GO:0051223,GO:0051234,GO:0051239,GO:0051240,GO:0051246,GO:0051247,GO:0051270,GO:0051301,GO:0051321,GO:0051338,GO:0051347,GO:0051438,GO:0051443,GO:0051640,GO:0051641,GO:0051648,GO:0051649,GO:0051650,GO:0051656,GO:0051668,GO:0051674,GO:0051704,GO:0051707,GO:0051716,GO:0051875,GO:0051904,GO:0051905,GO:0051960,GO:0051962,GO:0055044,GO:0060255,GO:0060284,GO:0060560,GO:0061024,GO:0061025,GO:0061640,GO:0061709,GO:0061912,GO:0061919,GO:0065003,GO:0065007,GO:0065008,GO:0065009,GO:0070201,GO:0070382,GO:0070727,GO:0070925,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0072384,GO:0072606,GO:0072657,GO:0072665,GO:0072741,GO:0080090,GO:0080115,GO:0080134,GO:0080135,GO:0090087,GO:0090110,GO:0090114,GO:0090174,GO:0090276,GO:0090277,GO:0090304,GO:0097159,GO:0097367,GO:0097458,GO:0097708,GO:0098542,GO:0098588,GO:0098590,GO:0098657,GO:0098791,GO:0098793,GO:0098805,GO:0098827,GO:0098930,GO:0099111,GO:0099503,GO:0099518,GO:0120035,GO:0140013,GO:0140056,GO:1900006,GO:1900101,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901575,GO:1902115,GO:1903008,GO:1903018,GO:1903020,GO:1903046,GO:1903047,GO:1903320,GO:1903322,GO:1903530,GO:1903532,GO:1904666,GO:1904668,GO:1904951,GO:1905037,GO:1905345,GO:1905897,GO:1990261,GO:1990778,GO:2000026,GO:2000145,GO:2000785	1.3.5.6	ko:K00514,ko:K03354,ko:K07874,ko:K07875	ko00906,ko01100,ko01110,ko04110,ko04111,ko04113,ko04114,ko04120,ko04914,ko05134,ko05166,map00906,map01100,map01110,map04110,map04111,map04113,map04114,map04120,map04914,map05134,map05166	M00097,M00389	R04798,R04800,R07511,R09656,R09658	RC01214,RC01959	ko00000,ko00001,ko00002,ko01000,ko03036,ko04031,ko04121,ko04131,ko04147	-	-	-	Ras
SX1_k127_4212776_1	1123239.KB898623_gene1658	7.271e-63	225.0	COG1028@1|root,COG1028@2|Bacteria,1U2GS@1239|Firmicutes,4H9R9@91061|Bacilli	91061|Bacilli	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	fabG1	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SX1_k127_4212776_2	224325.AF_0578	1.892e-32	141.0	COG2234@1|root,arCOG02962@2157|Archaea	2157|Archaea	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
SX1_k127_4212776_3	945713.IALB_1817	4.215e-29	131.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
SX1_k127_4212776_0	403833.Pmob_0722	3.061e-101	365.0	COG0383@1|root,COG0383@2|Bacteria,2GC0D@200918|Thermotogae	200918|Thermotogae	G	Glycoside hydrolase family 38 central region	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
SX1_k127_4216453_2	556261.HMPREF0240_01653	1.142e-16	83.0	COG0407@1|root,COG0407@2|Bacteria,1V4WM@1239|Firmicutes,24YPF@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX1_k127_4216453_1	591019.Shell_1234	1.55e-28	129.0	COG1474@1|root,arCOG00467@2157|Archaea,2XPZB@28889|Crenarchaeota	28889|Crenarchaeota	L	Involved in regulation of DNA replication	cdc6-2	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_22,Cdc6_C
SX1_k127_4216453_3	591019.Shell_0668	0.0004861	48.0	COG4945@1|root,arCOG01310@2157|Archaea,arCOG03771@2157|Archaea,2XPP7@28889|Crenarchaeota	28889|Crenarchaeota	G	to be involved in regulation of amylopullulanase-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Glucodextran_C
SX1_k127_4216453_0	1211035.CD30_04325	4.959e-95	336.0	COG2366@1|root,COG2366@2|Bacteria,1UFHA@1239|Firmicutes,4HACM@91061|Bacilli,3IWY5@400634|Lysinibacillus	91061|Bacilli	S	Beta-lactam antibiotic acylase	acyII	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
SX1_k127_4234433_0	225117.XP_009334262.1	3.569e-36	144.0	COG1100@1|root,KOG0087@2759|Eukaryota,37KFT@33090|Viridiplantae,3GB3F@35493|Streptophyta,4JFAH@91835|fabids	35493|Streptophyta	U	Ras-related protein	-	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0005795,GO:0005798,GO:0005802,GO:0005829,GO:0005886,GO:0006810,GO:0006891,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0012505,GO:0016020,GO:0016192,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0031410,GO:0031982,GO:0031984,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0048193,GO:0048219,GO:0050896,GO:0051179,GO:0051234,GO:0071944,GO:0097159,GO:0097367,GO:0097708,GO:0098791,GO:1901265,GO:1901363	-	ko:K07904,ko:K07976	ko04144,ko04961,ko04962,ko04972,map04144,map04961,map04962,map04972	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
SX1_k127_4234433_1	1321778.HMPREF1982_04438	4.271e-06	59.0	COG1073@1|root,COG1073@2|Bacteria,1UQS2@1239|Firmicutes,24F94@186801|Clostridia	186801|Clostridia	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	Chlorophyllase2,Hydrolase_4,Peptidase_S15
SX1_k127_4247472_3	7070.TC015021-PA	0.000679	52.0	28M43@1|root,2QTM0@2759|Eukaryota,39R11@33154|Opisthokonta,3BBTA@33208|Metazoa,3CZDB@33213|Bilateria,41YPY@6656|Arthropoda,3SJWE@50557|Insecta	33208|Metazoa	S	It is involved in the biological process described with protein targeting to Golgi	GOLGA4	GO:0000138,GO:0001558,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0005795,GO:0005802,GO:0005829,GO:0006810,GO:0006892,GO:0006893,GO:0007275,GO:0007399,GO:0008104,GO:0008150,GO:0008361,GO:0009987,GO:0010720,GO:0010769,GO:0010770,GO:0010975,GO:0010976,GO:0012505,GO:0015031,GO:0015833,GO:0016043,GO:0016192,GO:0017016,GO:0017137,GO:0019899,GO:0022008,GO:0022603,GO:0022604,GO:0030154,GO:0030306,GO:0030307,GO:0030516,GO:0031267,GO:0031344,GO:0031346,GO:0031984,GO:0031985,GO:0032501,GO:0032502,GO:0032535,GO:0033036,GO:0034613,GO:0040008,GO:0042802,GO:0042803,GO:0042886,GO:0043001,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0045595,GO:0045597,GO:0045664,GO:0045666,GO:0045773,GO:0045927,GO:0046983,GO:0048193,GO:0048518,GO:0048522,GO:0048638,GO:0048639,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050767,GO:0050769,GO:0050770,GO:0050772,GO:0050789,GO:0050793,GO:0050794,GO:0051020,GO:0051094,GO:0051128,GO:0051130,GO:0051179,GO:0051234,GO:0051239,GO:0051240,GO:0051641,GO:0051960,GO:0051962,GO:0060284,GO:0061387,GO:0061951,GO:0065007,GO:0065008,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0072657,GO:0072659,GO:0090066,GO:0090150,GO:0098791,GO:0098876,GO:0120035,GO:1990778,GO:2000026	-	ko:K20283	-	-	-	-	ko00000,ko04131	-	-	-	GRIP
SX1_k127_4247472_2	399550.Smar_0428	1.529e-09	66.0	arCOG05489@1|root,arCOG05489@2157|Archaea,2XQP7@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_4247472_1	399550.Smar_0709	9.907e-18	93.0	COG2120@1|root,arCOG03460@2157|Archaea,2XQXY@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM LmbE family protein	-	-	-	ko:K22408	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
SX1_k127_4247472_0	342949.PNA2_1071	1.239e-37	153.0	COG1058@1|root,arCOG00215@2157|Archaea,2XUAN@28890|Euryarchaeota,242S9@183968|Thermococci	183968|Thermococci	S	Probable molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
SX1_k127_4252790_1	416591.Tlet_0046	1.305e-58	220.0	COG2211@1|root,COG2211@2|Bacteria,2GDVW@200918|Thermotogae	200918|Thermotogae	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX1_k127_4252790_2	411468.CLOSCI_02828	1.426e-22	109.0	COG0348@1|root,COG0348@2|Bacteria,1TPHF@1239|Firmicutes,247KH@186801|Clostridia,21YNG@1506553|Lachnoclostridium	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
SX1_k127_4252790_0	406327.Mevan_1572	4.06e-172	551.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,23Q3P@183939|Methanococci	183939|Methanococci	S	SMART KH domain protein	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_2,KH_7,Lactamase_B,Lactamase_B_6,RMMBL
SX1_k127_425946_2	1464048.JNZS01000004_gene1620	0.0002336	46.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4D8QQ@85008|Micromonosporales	201174|Actinobacteria	P	Copper-translocating P-type atpase	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
SX1_k127_425946_1	926550.CLDAP_06980	2.294e-23	107.0	COG0406@1|root,COG0406@2|Bacteria,2G731@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the phosphoglycerate mutase family	-	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
SX1_k127_425946_0	649747.HMPREF0083_00840	1.304e-66	239.0	COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,4HA4N@91061|Bacilli,26QN5@186822|Paenibacillaceae	91061|Bacilli	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
SX1_k127_4260324_2	403833.Pmob_1586	1.827e-68	242.0	COG0473@1|root,COG0473@2|Bacteria,2GCZJ@200918|Thermotogae	200918|Thermotogae	H	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.83,1.1.1.85,1.1.1.93,4.1.1.73	ko:K00052,ko:K07246	ko00290,ko00630,ko00650,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00630,map00650,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00215,R00994,R01751,R02545,R04426,R06180,R10052	RC00084,RC00105,RC00417,RC00594,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
SX1_k127_4260324_5	1365176.N186_02760	3.408e-08	57.0	COG2036@1|root,arCOG02144@2157|Archaea,2XSK2@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM Transcription factor CBF NF-Y	-	-	-	-	-	-	-	-	-	-	-	-	CBFD_NFYB_HMF
SX1_k127_4260324_0	368408.Tpen_0497	3.303e-142	476.0	COG1241@1|root,arCOG00439@2157|Archaea,2XQ2Z@28889|Crenarchaeota	28889|Crenarchaeota	L	Belongs to the MCM family	-	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Intein_splicing,MCM,MCM_N,MCM_OB
SX1_k127_4260324_3	673860.AciM339_1496	4.095e-52	194.0	COG1100@1|root,arCOG01225@2157|Archaea,2XWN4@28890|Euryarchaeota,3F2J6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Conserved hypothetical ATP binding protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	ATP_bind_1
SX1_k127_4260324_1	644281.MFS40622_0827	2.322e-85	299.0	COG0119@1|root,arCOG02092@2157|Archaea,2XSZJ@28890|Euryarchaeota,23QBT@183939|Methanococci	183939|Methanococci	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
SX1_k127_4260324_4	634498.mru_1282	1.633e-12	70.0	COG1958@1|root,arCOG00998@2157|Archaea,2XZTF@28890|Euryarchaeota,23P7B@183925|Methanobacteria	183925|Methanobacteria	K	Belongs to the snRNP Sm proteins family	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
SX1_k127_4280639_0	1121430.JMLG01000006_gene1778	3.328e-119	394.0	COG0499@1|root,COG0499@2|Bacteria,1TQY0@1239|Firmicutes,248S3@186801|Clostridia,2604M@186807|Peptococcaceae	186801|Clostridia	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
SX1_k127_4280639_1	1306947.ARQD01000002_gene379	7.332e-16	81.0	COG3118@1|root,COG3118@2|Bacteria,2NPNZ@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
SX1_k127_4315491_0	1304880.JAGB01000002_gene1606	3.619e-127	416.0	COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,247Z9@186801|Clostridia	186801|Clostridia	C	Psort location Cytoplasmic, score	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
SX1_k127_4315491_1	865861.AZSU01000005_gene934	1.061e-43	164.0	COG3386@1|root,COG3386@2|Bacteria,1UN4I@1239|Firmicutes,25GWC@186801|Clostridia,36Q09@31979|Clostridiaceae	186801|Clostridia	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_4349207_1	1044.EH31_09205	5.497e-29	129.0	COG0286@1|root,COG0286@2|Bacteria,1MWUJ@1224|Proteobacteria,2TT41@28211|Alphaproteobacteria,2K4MP@204457|Sphingomonadales	204457|Sphingomonadales	V	InterPro DEAD DEAH box helicase	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
SX1_k127_4349207_5	439481.Aboo_1226	0.0006782	54.0	arCOG03256@1|root,arCOG03439@1|root,arCOG07760@1|root,arCOG03256@2157|Archaea,arCOG03439@2157|Archaea,arCOG07760@2157|Archaea,2Y704@28890|Euryarchaeota,3F320@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein.	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,CUB,Peptidase_C25,Propeptide_C25
SX1_k127_4349207_4	439481.Aboo_1226	3.375e-08	68.0	arCOG03256@1|root,arCOG03439@1|root,arCOG07760@1|root,arCOG03256@2157|Archaea,arCOG03439@2157|Archaea,arCOG07760@2157|Archaea,2Y704@28890|Euryarchaeota,3F320@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein.	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,CUB,Peptidase_C25,Propeptide_C25
SX1_k127_4349207_2	86106.I862_06725	3.717e-26	114.0	COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,2U7B5@28211|Alphaproteobacteria,47FCY@766|Rickettsiales	766|Rickettsiales	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
SX1_k127_4349207_0	266117.Rxyl_3023	2.519e-95	325.0	COG1171@1|root,COG1171@2|Bacteria,2I8ZW@201174|Actinobacteria,4CQ5T@84995|Rubrobacteria	84995|Rubrobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.15	ko:K01751	-	-	-	-	ko00000,ko01000	-	-	-	PALP
SX1_k127_4349207_3	5482.XP_002547869.1	1.372e-24	105.0	COG0120@1|root,KOG3075@2759|Eukaryota,38HSY@33154|Opisthokonta,3NWRM@4751|Fungi,3QNUC@4890|Ascomycota,3RT79@4891|Saccharomycetes,47A91@766764|Debaryomycetaceae	4751|Fungi	H	ketol-isomerase	RKI1	GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009052,GO:0009058,GO:0009110,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019321,GO:0019362,GO:0019438,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
SX1_k127_4353043_2	694440.JOMF01000009_gene766	1.15e-16	82.0	arCOG03518@1|root,arCOG03518@2157|Archaea,2Y0DN@28890|Euryarchaeota,2NAXI@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_4353043_0	323259.Mhun_2999	2.892e-43	165.0	arCOG02140@1|root,arCOG02140@2157|Archaea,2Y5Y2@28890|Euryarchaeota,2NBBF@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_4353043_1	192952.MM_2934	4.646e-39	151.0	arCOG02138@1|root,arCOG02138@2157|Archaea,2Y150@28890|Euryarchaeota,2NA0H@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_4353043_3	351160.RCIX1321	1.336e-16	79.0	COG4096@1|root,arCOG00880@2157|Archaea,2XUEI@28890|Euryarchaeota,2N9C8@224756|Methanomicrobia	224756|Methanomicrobia	V	EcoEI R protein C-terminal	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	EcoEI_R_C,HSDR_N,Helicase_C,ResIII
SX1_k127_4356710_1	536227.CcarbDRAFT_0447	7.706e-29	121.0	COG3467@1|root,COG3467@2|Bacteria	2|Bacteria	T	pyridoxamine 5'-phosphate	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
SX1_k127_4356710_2	1459636.NTE_02289	0.0004084	48.0	arCOG03770@1|root,arCOG03770@2157|Archaea	2157|Archaea	M	metalloendopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_4356710_0	1304885.AUEY01000047_gene79	3.149e-75	274.0	COG1032@1|root,COG1032@2|Bacteria,1MU15@1224|Proteobacteria,42N12@68525|delta/epsilon subdivisions,2WK0X@28221|Deltaproteobacteria,2MI8S@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SX1_k127_436059_1	5888.CAK70494	5.227e-34	137.0	KOG0084@1|root,KOG0084@2759|Eukaryota,3ZBKW@5878|Ciliophora	5878|Ciliophora	U	Rab subfamily of small GTPases	-	-	-	ko:K07874	ko05134,map05134	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
SX1_k127_436059_3	269797.Mbar_A0933	2.19e-25	118.0	COG5635@1|root,arCOG02967@2157|Archaea,2Y7RH@28890|Euryarchaeota	28890|Euryarchaeota	T	HEAT repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
SX1_k127_436059_2	926569.ANT_22340	2.873e-26	124.0	COG2211@1|root,COG2211@2|Bacteria,2G6RZ@200795|Chloroflexi	200795|Chloroflexi	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX1_k127_436059_0	158190.SpiGrapes_0749	3.95e-44	175.0	COG1409@1|root,COG1409@2|Bacteria,2JANM@203691|Spirochaetes	203691|Spirochaetes	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K22390	-	-	-	-	ko00000	-	-	-	Metallophos
SX1_k127_4375820_0	1031288.AXAA01000030_gene228	1.642e-82	279.0	COG0176@1|root,COG0176@2|Bacteria,1TP4Q@1239|Firmicutes,248KZ@186801|Clostridia,36EK7@31979|Clostridiaceae	186801|Clostridia	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
SX1_k127_4404558_2	484019.THA_1359	6.129e-16	80.0	COG0561@1|root,COG0561@2|Bacteria,2GD1F@200918|Thermotogae	200918|Thermotogae	S	HAD-superfamily hydrolase, subfamily IIB	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
SX1_k127_4404558_6	35128.Thaps264799	0.0003295	52.0	KOG3861@1|root,KOG3861@2759|Eukaryota,2XF0F@2836|Bacillariophyta	2836|Bacillariophyta	W	intraciliary anterograde transport	-	-	-	ko:K19681	-	-	-	-	ko00000,ko03036	-	-	-	-
SX1_k127_4404558_0	1144313.PMI10_01485	7.533e-70	261.0	COG3250@1|root,COG3250@2|Bacteria,4NESZ@976|Bacteroidetes,1HXMX@117743|Flavobacteriia,2NU3K@237|Flavobacterium	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.2.1.31	ko:K01195	ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142	M00014,M00076,M00077,M00078,M00129	R01478,R04979,R07818,R08127,R08260,R10830	RC00055,RC00171,RC00529,RC00530,RC00714,RC01251	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
SX1_k127_4404558_5	290402.Cbei_3317	7.26e-08	64.0	COG0477@1|root,COG2814@2|Bacteria,1TRDJ@1239|Firmicutes,247N6@186801|Clostridia,36EU0@31979|Clostridiaceae	186801|Clostridia	EGP	Major facilitator superfamily	-	-	-	ko:K08161	-	-	-	-	ko00000,ko02000	2.A.1.2.20	-	-	MFS_1,Sugar_tr
SX1_k127_4404558_3	1121904.ARBP01000002_gene6846	1.427e-15	87.0	COG5434@1|root,COG5434@2|Bacteria,4NG62@976|Bacteroidetes,47TF7@768503|Cytophagia	976|Bacteroidetes	M	Heparinase II/III N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_lyase,Beta_helix,Hepar_II_III,Hepar_II_III_N
SX1_k127_4404558_1	1121422.AUMW01000023_gene2737	5.881e-21	96.0	2DMZP@1|root,32UMQ@2|Bacteria,1VHU7@1239|Firmicutes,24QKJ@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
SX1_k127_4404558_4	2074.JNYD01000026_gene680	3.322e-10	72.0	COG0477@1|root,COG2814@2|Bacteria,2GJF6@201174|Actinobacteria,4E094@85010|Pseudonocardiales	201174|Actinobacteria	EGP	Sugar (and other) transporter	-	-	-	ko:K08369	-	-	-	-	ko00000,ko02000	2.A.1	-	-	MFS_1,Sugar_tr
SX1_k127_4405878_1	1337936.IJ00_04365	1.085e-26	114.0	COG0006@1|root,COG0006@2|Bacteria,1G0KH@1117|Cyanobacteria,1HJU9@1161|Nostocales	1117|Cyanobacteria	E	Belongs to the peptidase M24B family	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
SX1_k127_4405878_2	1450525.JATV01000009_gene761	1.6e-22	99.0	COG1073@1|root,COG1073@2|Bacteria,4NFCA@976|Bacteroidetes,1HXRJ@117743|Flavobacteriia,2NSW5@237|Flavobacterium	976|Bacteroidetes	S	PS-10 peptidase S37	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S37
SX1_k127_4405878_3	945713.IALB_2742	4.342e-05	49.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	ptp	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S37
SX1_k127_4405878_0	1296416.JACB01000027_gene4078	5.538e-38	151.0	COG0823@1|root,COG0823@2|Bacteria,4NIV7@976|Bacteroidetes,1HYWC@117743|Flavobacteriia,2YI86@290174|Aquimarina	976|Bacteroidetes	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
SX1_k127_4411323_1	1408473.JHXO01000012_gene357	9.697e-50	186.0	COG2273@1|root,COG2273@2|Bacteria,4P4NI@976|Bacteroidetes	976|Bacteroidetes	G	Hydrolase Family 16	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_4411323_0	383372.Rcas_2554	9.399e-136	447.0	COG3669@1|root,COG3669@2|Bacteria,2G801@200795|Chloroflexi	200795|Chloroflexi	G	PFAM glycoside hydrolase family 29 (alpha-L-fucosidase)	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
SX1_k127_4411323_2	1210884.HG799464_gene10782	2.976e-26	114.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
SX1_k127_4422415_0	247490.KSU1_C0728	1.468e-78	272.0	COG1194@1|root,COG1194@2|Bacteria,2IY33@203682|Planctomycetes	203682|Planctomycetes	L	COG1194 A G-specific DNA glycosylase	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
SX1_k127_4422415_1	1414720.CBYM010000014_gene2718	2.887e-18	95.0	COG1606@1|root,COG1606@2|Bacteria,1TPB2@1239|Firmicutes,2485J@186801|Clostridia,36DE3@31979|Clostridiaceae	186801|Clostridia	S	TIGRFAM TIGR00268 family protein	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	ATP_bind_3,NAD_synthase,QueC
SX1_k127_4422415_2	374847.Kcr_0480	2.949e-16	84.0	COG1641@1|root,arCOG02701@2157|Archaea	2157|Archaea	S	Belongs to the LarC family	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
SX1_k127_4430220_0	1385935.N836_19815	4.168e-30	134.0	COG1020@1|root,COG1020@2|Bacteria,1G2QF@1117|Cyanobacteria,1HD5R@1150|Oscillatoriales	1117|Cyanobacteria	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	Condensation
SX1_k127_4431118_0	1449050.JNLE01000005_gene5207	8.358e-08	63.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
SX1_k127_4432591_1	374847.Kcr_1258	6.055e-54	196.0	COG1363@1|root,arCOG01518@2157|Archaea	2157|Archaea	G	peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
SX1_k127_4432591_0	1041930.Mtc_1124	3.365e-121	407.0	COG1205@1|root,arCOG00555@2157|Archaea,2XTPR@28890|Euryarchaeota,2N96V@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
SX1_k127_4433935_1	1292035.H476_0635	3.892e-43	162.0	COG0626@1|root,COG0626@2|Bacteria,1TPC7@1239|Firmicutes,25E6I@186801|Clostridia,25QSK@186804|Peptostreptococcaceae	186801|Clostridia	E	Cys/Met metabolism PLP-dependent enzyme	megL	-	2.5.1.48,4.4.1.11	ko:K01739,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00999,R01288,R02508,R03217,R03260,R04770,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00420,RC01209,RC01210,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
SX1_k127_4433935_2	913865.DOT_3289	7.507e-36	143.0	COG1853@1|root,COG1853@2|Bacteria,1V1EA@1239|Firmicutes,24FWS@186801|Clostridia,2620R@186807|Peptococcaceae	186801|Clostridia	S	DIM6 NTAB family	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
SX1_k127_4433935_0	1089548.KI783301_gene230	4.968e-61	228.0	COG2211@1|root,COG2211@2|Bacteria,1TRA5@1239|Firmicutes,4HJPK@91061|Bacilli	91061|Bacilli	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX1_k127_444683_4	931276.Cspa_c51490	2.543e-26	109.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247T8@186801|Clostridia,36EMB@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SX1_k127_444683_0	1540257.JQMW01000009_gene2854	1.029e-253	797.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,36E4P@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SX1_k127_444683_2	926569.ANT_02600	1.814e-111	381.0	COG1132@1|root,COG1132@2|Bacteria,2G5RP@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SX1_k127_444683_3	1380390.JIAT01000016_gene5496	2.076e-65	252.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4CPT4@84995|Rubrobacteria	84995|Rubrobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SX1_k127_444683_1	1347392.CCEZ01000029_gene1719	1.3e-172	554.0	COG0535@1|root,COG0535@2|Bacteria,1TR52@1239|Firmicutes,247SB@186801|Clostridia,36DWE@31979|Clostridiaceae	186801|Clostridia	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
SX1_k127_444683_5	6238.CBG02488	4.503e-26	111.0	KOG0093@1|root,KOG0093@2759|Eukaryota,38F35@33154|Opisthokonta,3BAAA@33208|Metazoa,3CREC@33213|Bilateria,40CKG@6231|Nematoda,1KVHG@119089|Chromadorea,40RU2@6236|Rhabditida	33208|Metazoa	U	Ras family	RAB3B	GO:0000003,GO:0000166,GO:0000902,GO:0000904,GO:0001505,GO:0001669,GO:0001671,GO:0001775,GO:0001882,GO:0001883,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003008,GO:0003016,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005829,GO:0005886,GO:0006464,GO:0006479,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006865,GO:0006887,GO:0006935,GO:0006955,GO:0006996,GO:0007005,GO:0007010,GO:0007154,GO:0007165,GO:0007264,GO:0007265,GO:0007267,GO:0007268,GO:0007269,GO:0007271,GO:0007274,GO:0007275,GO:0007399,GO:0007409,GO:0007585,GO:0007600,GO:0007610,GO:0007617,GO:0007618,GO:0008021,GO:0008022,GO:0008047,GO:0008092,GO:0008150,GO:0008152,GO:0008213,GO:0009605,GO:0009628,GO:0009653,GO:0009791,GO:0009987,GO:0010646,GO:0010647,GO:0012505,GO:0012506,GO:0014047,GO:0015711,GO:0015800,GO:0015849,GO:0016020,GO:0016043,GO:0016050,GO:0016079,GO:0016188,GO:0016192,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017022,GO:0017076,GO:0017111,GO:0017156,GO:0017157,GO:0017158,GO:0018125,GO:0018193,GO:0018198,GO:0019001,GO:0019003,GO:0019098,GO:0019538,GO:0019882,GO:0019899,GO:0019953,GO:0021700,GO:0022008,GO:0022414,GO:0023051,GO:0023052,GO:0023056,GO:0023061,GO:0030030,GO:0030133,GO:0030135,GO:0030136,GO:0030141,GO:0030154,GO:0030182,GO:0030234,GO:0030323,GO:0030324,GO:0030424,GO:0030658,GO:0030659,GO:0030662,GO:0030665,GO:0030667,GO:0030672,GO:0030742,GO:0030865,GO:0031090,GO:0031175,GO:0031224,GO:0031225,GO:0031300,GO:0031338,GO:0031410,GO:0031489,GO:0031630,GO:0031982,GO:0032225,GO:0032226,GO:0032228,GO:0032259,GO:0032386,GO:0032482,GO:0032501,GO:0032502,GO:0032504,GO:0032535,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032781,GO:0032879,GO:0032940,GO:0032989,GO:0032990,GO:0032991,GO:0033043,GO:0033267,GO:0035295,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0036230,GO:0036465,GO:0040011,GO:0040012,GO:0042119,GO:0042221,GO:0042330,GO:0042995,GO:0043005,GO:0043051,GO:0043085,GO:0043167,GO:0043168,GO:0043170,GO:0043195,GO:0043226,GO:0043227,GO:0043229,GO:0043269,GO:0043270,GO:0043299,GO:0043312,GO:0043412,GO:0043414,GO:0043462,GO:0043679,GO:0043687,GO:0043954,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044306,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044444,GO:0044446,GO:0044456,GO:0044463,GO:0044464,GO:0044703,GO:0045054,GO:0045055,GO:0045202,GO:0045321,GO:0045921,GO:0046717,GO:0046903,GO:0046907,GO:0046928,GO:0046942,GO:0048167,GO:0048168,GO:0048172,GO:0048468,GO:0048471,GO:0048489,GO:0048513,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0048609,GO:0048666,GO:0048667,GO:0048699,GO:0048731,GO:0048786,GO:0048789,GO:0048790,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0050789,GO:0050790,GO:0050794,GO:0050795,GO:0050804,GO:0050806,GO:0050808,GO:0050877,GO:0050896,GO:0050954,GO:0050975,GO:0051021,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051117,GO:0051128,GO:0051179,GO:0051234,GO:0051336,GO:0051345,GO:0051580,GO:0051582,GO:0051584,GO:0051586,GO:0051588,GO:0051590,GO:0051602,GO:0051640,GO:0051641,GO:0051648,GO:0051649,GO:0051650,GO:0051656,GO:0051704,GO:0051716,GO:0051940,GO:0051944,GO:0051952,GO:0051954,GO:0060198,GO:0060199,GO:0060200,GO:0060201,GO:0060203,GO:0060259,GO:0060341,GO:0060541,GO:0060589,GO:0060590,GO:0060627,GO:0061200,GO:0061202,GO:0061564,GO:0061670,GO:0065007,GO:0065008,GO:0065009,GO:0070081,GO:0070083,GO:0070382,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0090066,GO:0097159,GO:0097223,GO:0097367,GO:0097458,GO:0097479,GO:0097480,GO:0097494,GO:0097708,GO:0098563,GO:0098588,GO:0098693,GO:0098772,GO:0098793,GO:0098805,GO:0098916,GO:0098993,GO:0099003,GO:0099177,GO:0099501,GO:0099503,GO:0099504,GO:0099536,GO:0099537,GO:0099558,GO:0099643,GO:0120025,GO:0120036,GO:0120038,GO:0120039,GO:0150034,GO:1900271,GO:1901265,GO:1901363,GO:1901564,GO:1902803,GO:1903305,GO:1903307,GO:1903530,GO:1903532,GO:1903998,GO:1990709,GO:2000300,GO:2001023,GO:2001025	-	ko:K06108,ko:K07882,ko:K07883	ko04721,ko04911,map04721,map04911	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
SX1_k127_4471212_0	1304885.AUEY01000018_gene1136	3.98e-49	178.0	COG0693@1|root,COG0693@2|Bacteria,1MY0C@1224|Proteobacteria,42TPX@68525|delta/epsilon subdivisions,2WNCR@28221|Deltaproteobacteria,2MPVR@213118|Desulfobacterales	28221|Deltaproteobacteria	S	DJ-1/PfpI family	-	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
SX1_k127_4471212_2	509635.N824_14380	6.816e-10	69.0	COG3393@1|root,COG3393@2|Bacteria,4PKIF@976|Bacteroidetes,1IY6G@117747|Sphingobacteriia	976|Bacteroidetes	S	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	FR47
SX1_k127_4471212_1	6500.XP_005103012.1	1.041e-19	96.0	2CN63@1|root,2QU2R@2759|Eukaryota,39WFD@33154|Opisthokonta,3BNGE@33208|Metazoa,3CVQ7@33213|Bilateria	33208|Metazoa	S	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	AAT
SX1_k127_4501202_0	318464.IO99_07525	7.437e-37	154.0	COG4552@1|root,COG4552@2|Bacteria	2|Bacteria	S	transferase activity, transferring acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
SX1_k127_4501202_1	1280950.HJO_01320	2.391e-23	106.0	COG0454@1|root,COG0456@2|Bacteria,1RHUD@1224|Proteobacteria,2UJA3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SX1_k127_4501202_2	1033810.HLPCO_002189	8.835e-05	48.0	COG3393@1|root,COG3393@2|Bacteria	2|Bacteria	S	Acetyltransferase (GNAT) family	-	-	-	ko:K06976	-	-	-	-	ko00000	-	-	-	Acetyltransf_1,FR47
SX1_k127_4506838_0	266748.HY04_09650	2.321e-42	162.0	COG0451@1|root,COG0451@2|Bacteria,4NI4C@976|Bacteroidetes,1HYXU@117743|Flavobacteriia	976|Bacteroidetes	M	Male sterility protein	-	-	-	-	-	-	-	-	-	-	-	-	3Beta_HSD,Epimerase
SX1_k127_4510636_1	1408473.JHXO01000003_gene2534	2.99e-11	68.0	COG0500@1|root,COG0500@2|Bacteria	2|Bacteria	Q	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25
SX1_k127_4510636_0	929562.Emtol_3878	4.829e-12	69.0	COG0500@1|root,COG0500@2|Bacteria,4PPBM@976|Bacteroidetes	976|Bacteroidetes	Q	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
SX1_k127_4510636_2	771875.Ferpe_0767	1.538e-08	65.0	COG1055@1|root,COG1055@2|Bacteria,2GC16@200918|Thermotogae	200918|Thermotogae	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
SX1_k127_4510815_1	1197130.BAFM01000003_gene653	1.942e-61	222.0	COG2159@1|root,arCOG01931@2157|Archaea	1197130.BAFM01000003_gene653|-	S	metal-dependent hydrolase of the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_4510815_0	96561.Dole_2635	5.539e-80	278.0	COG1148@1|root,COG1148@2|Bacteria,1N26U@1224|Proteobacteria,43BRX@68525|delta/epsilon subdivisions,2WKFG@28221|Deltaproteobacteria,2MJAN@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
SX1_k127_4512052_10	391623.TERMP_00347	4.046e-05	47.0	COG0674@1|root,arCOG01606@2157|Archaea,2XSUJ@28890|Euryarchaeota,243RK@183968|Thermococci	183968|Thermococci	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
SX1_k127_4512052_2	1220534.B655_0402	1.299e-107	357.0	COG1013@1|root,arCOG01599@2157|Archaea,2XTW2@28890|Euryarchaeota,23PWY@183925|Methanobacteria	183925|Methanobacteria	C	TIGRFAM 2-oxoacid acceptor oxidoreductase, beta subunit, pyruvate 2-ketoisovalerate	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
SX1_k127_4512052_7	1149133.ppKF707_1096	1.631e-18	87.0	COG1254@1|root,COG1254@2|Bacteria,1N6NU@1224|Proteobacteria,1SCPF@1236|Gammaproteobacteria,1YGSN@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	C	Acylphosphatase	acyP	GO:0003674,GO:0003824,GO:0003998,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016787,GO:0016817,GO:0016818,GO:0050896	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	iSBO_1134.SBO_2263,iSF_1195.SF0969,iSFxv_1172.SFxv_1053,iS_1188.S1036	Acylphosphatase
SX1_k127_4512052_6	589924.Ferp_1929	8.396e-34	140.0	COG1968@1|root,arCOG04761@2157|Archaea,2XTYX@28890|Euryarchaeota	28890|Euryarchaeota	I	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP)	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
SX1_k127_4512052_4	589924.Ferp_1786	1.181e-53	197.0	COG1059@1|root,arCOG04357@2157|Archaea,2XWSZ@28890|Euryarchaeota,24660@183980|Archaeoglobi	183980|Archaeoglobi	L	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)	ogg	-	4.2.99.18	ko:K03653	-	-	-	-	ko00000,ko01000	-	-	-	-
SX1_k127_4512052_5	644281.MFS40622_0994	3.077e-42	165.0	COG1093@1|root,arCOG04107@2157|Archaea,2XTV0@28890|Euryarchaeota,23PZU@183939|Methanococci	183939|Methanococci	J	Translation initiation factor 2	eif2a	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K03237	ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168	-	-	-	ko00000,ko00001,ko03012	-	-	-	EIF_2_alpha,S1
SX1_k127_4512052_8	178306.PAE3031	6.362e-12	68.0	COG2260@1|root,arCOG00906@2157|Archaea,2XR3J@28889|Crenarchaeota	28889|Crenarchaeota	J	more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA	nop10	-	-	ko:K11130	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko03009,ko03032	-	-	-	Nop10p
SX1_k127_4512052_3	273057.SSO0223	7.118e-102	345.0	COG0086@1|root,arCOG04256@2157|Archaea,2XPSD@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03042	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_5
SX1_k127_4512052_0	633148.Tagg_1406	1.161e-285	910.0	COG0086@1|root,arCOG04257@2157|Archaea,2XPT5@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA1	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
SX1_k127_4512052_1	941824.TCEL_00148	1.407e-158	517.0	COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,2482E@186801|Clostridia,36DBK@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS01075	CTP_synth_N,GATase
SX1_k127_4512052_9	1207058.L53_12650	3.044e-08	65.0	2EY8I@1|root,33RH3@2|Bacteria,1NS5H@1224|Proteobacteria,2UP0R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_4514008_0	1183377.Py04_0062	4.341e-42	162.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,242PW@183968|Thermococci	183968|Thermococci	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ1	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
SX1_k127_453419_2	374847.Kcr_0638	8.927e-18	97.0	arCOG02559@1|root,arCOG02559@2157|Archaea	2157|Archaea	P	by modhmm	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
SX1_k127_453419_0	439235.Dalk_3740	6.958e-60	222.0	COG0644@1|root,COG0644@2|Bacteria	2|Bacteria	C	geranylgeranyl reductase activity	cbrA	GO:0000166,GO:0003674,GO:0005488,GO:0008150,GO:0008152,GO:0009404,GO:0009987,GO:0019748,GO:0030153,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0048037,GO:0050660,GO:0050662,GO:0097159,GO:1901265,GO:1901363	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
SX1_k127_453419_1	1347368.HG964406_gene6385	6.529e-44	169.0	COG0454@1|root,COG0456@2|Bacteria,1TYX1@1239|Firmicutes,4IRK4@91061|Bacilli	91061|Bacilli	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SX1_k127_4553363_1	871968.DESME_10400	1.472e-37	149.0	COG1670@1|root,COG1670@2|Bacteria,1UI20@1239|Firmicutes,24HRV@186801|Clostridia	186801|Clostridia	J	Acetyltransferase GNAT family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_4
SX1_k127_4553363_3	1121926.AXWO01000007_gene56	2.324e-06	57.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	2.3.1.128	ko:K01163,ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
SX1_k127_4553363_2	706587.Desti_4875	2.494e-28	124.0	COG2220@1|root,COG2220@2|Bacteria,1QB9E@1224|Proteobacteria,42N7W@68525|delta/epsilon subdivisions,2WNMC@28221|Deltaproteobacteria,2MQPI@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
SX1_k127_4553363_0	224325.AF_2100	2.234e-52	193.0	COG0028@1|root,arCOG01998@2157|Archaea,2XT5F@28890|Euryarchaeota,245VB@183980|Archaeoglobi	28890|Euryarchaeota	E	Acetolactate synthase, large subunit	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
SX1_k127_4556603_2	523791.Kkor_1113	2.897e-06	49.0	2CHCP@1|root,32S5R@2|Bacteria,1MZ97@1224|Proteobacteria,1S8M3@1236|Gammaproteobacteria,1XPJY@135619|Oceanospirillales	135619|Oceanospirillales	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
SX1_k127_4556603_1	1305737.JAFX01000001_gene1378	6.291e-10	61.0	2CHCP@1|root,32S5R@2|Bacteria,4NS9G@976|Bacteroidetes,47RF4@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
SX1_k127_4556603_0	1449343.JQLQ01000002_gene2376	1.609e-19	96.0	COG3449@1|root,COG3449@2|Bacteria,1V4SC@1239|Firmicutes,4HHNI@91061|Bacilli,27GD1@186828|Carnobacteriaceae	91061|Bacilli	L	SOUL heme-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SOUL
SX1_k127_4600162_0	394503.Ccel_2119	9.947e-203	642.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,36E0I@31979|Clostridiaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
SX1_k127_4600162_2	342451.SSP0028	1.089e-61	226.0	COG0863@1|root,COG0863@2|Bacteria,1VC9K@1239|Firmicutes,4HSVW@91061|Bacilli	91061|Bacilli	L	DNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
SX1_k127_4600162_3	1163389.OOM_1169	4.486e-34	142.0	COG2267@1|root,COG2267@2|Bacteria,1NYNM@1224|Proteobacteria,1T1T3@1236|Gammaproteobacteria,460V8@72273|Thiotrichales	72273|Thiotrichales	I	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
SX1_k127_4600162_1	453591.Igni_0001	3.163e-173	561.0	COG0532@1|root,arCOG01560@2157|Archaea,2XPQ5@28889|Crenarchaeota	28889|Crenarchaeota	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D4,IF-2
SX1_k127_4600162_5	572546.Arcpr_0876	1.316e-27	116.0	COG2125@1|root,arCOG01946@2157|Archaea,2XXZJ@28890|Euryarchaeota,2470Y@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the eukaryotic ribosomal protein eS6 family	rps6e	-	-	ko:K02991	ko01521,ko03010,ko04066,ko04150,ko04151,ko04371,ko04714,ko04910,ko05205,map01521,map03010,map04066,map04150,map04151,map04371,map04714,map04910,map05205	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S6e
SX1_k127_4600162_8	1006006.Mcup_0028	3.514e-15	76.0	COG2075@1|root,arCOG01950@2157|Archaea,2XR6Q@28889|Crenarchaeota	28889|Crenarchaeota	J	binds to the 23S rRNA	rpl24e	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904	-	ko:K02896	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L24e
SX1_k127_4600162_4	565033.GACE_1331	3.864e-29	120.0	COG1358@1|root,arCOG01751@2157|Archaea,2XX4C@28890|Euryarchaeota,246BV@183980|Archaeoglobi	183980|Archaeoglobi	J	Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs	rpl7ae	-	-	ko:K02936	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03009,ko03011	-	-	-	Ribosomal_L7Ae
SX1_k127_4600162_6	1184251.TCELL_0541	8.195e-20	91.0	COG2053@1|root,arCOG04314@2157|Archaea,2XQTB@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS28 family	rps28e	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990904	-	ko:K02979	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S28e
SX1_k127_4600162_7	3880.AES96168	3.257e-18	85.0	COG1644@1|root,KOG2140@1|root,KOG2140@2759|Eukaryota,KOG3497@2759|Eukaryota,37VZ5@33090|Viridiplantae,3GK6Q@35493|Streptophyta,4JQQB@91835|fabids	35493|Streptophyta	K	DNA-directed RNA polymerases I, II, and III subunit	-	GO:0000428,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005665,GO:0005666,GO:0005730,GO:0005736,GO:0008270,GO:0016591,GO:0030880,GO:0031974,GO:0031981,GO:0032991,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044451,GO:0044452,GO:0044464,GO:0046872,GO:0046914,GO:0055029,GO:0061695,GO:0070013,GO:1902494,GO:1990234	-	ko:K03007	ko00230,ko00240,ko01100,ko03020,ko04623,ko05016,ko05169,map00230,map00240,map01100,map03020,map04623,map05016,map05169	M00180,M00181,M00182	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko03021,ko03400	-	-	-	RNA_pol_N
SX1_k127_4607625_2	1217656.F964_01895	2.299e-42	166.0	COG4221@1|root,COG4221@2|Bacteria,1RF5D@1224|Proteobacteria,1S5AC@1236|Gammaproteobacteria,3NN1S@468|Moraxellaceae	1236|Gammaproteobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SX1_k127_4607625_1	1459636.NTE_02173	9.714e-103	347.0	COG0505@1|root,arCOG00064@2157|Archaea,41SF0@651137|Thaumarchaeota	651137|Thaumarchaeota	E	carbamoyl-phosphate synthase, small subunit	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
SX1_k127_4607625_0	436308.Nmar_1085	8.278e-262	826.0	COG0458@1|root,arCOG01594@2157|Archaea,41SBF@651137|Thaumarchaeota	651137|Thaumarchaeota	E	MGS-like domain	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
SX1_k127_4608523_0	349161.Dred_2564	8.299e-54	198.0	COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,24CW2@186801|Clostridia,266RD@186807|Peptococcaceae	186801|Clostridia	P	Part of an ABC transporter complex. Responsible for energy coupling to the transport system	-	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
SX1_k127_4608523_1	1280682.AUKA01000006_gene2912	2.204e-07	58.0	COG0619@1|root,COG0619@2|Bacteria,1U6XW@1239|Firmicutes,24EV0@186801|Clostridia,4BX3V@830|Butyrivibrio	186801|Clostridia	P	Cobalt transport protein	cbiQ	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
SX1_k127_460965_1	656519.Halsa_1989	1.091e-64	231.0	COG0075@1|root,COG0075@2|Bacteria,1TPS0@1239|Firmicutes,24919@186801|Clostridia,3WAMM@53433|Halanaerobiales	186801|Clostridia	E	PFAM Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
SX1_k127_460965_0	309799.DICTH_1741	2.481e-80	277.0	COG0111@1|root,COG0111@2|Bacteria	2|Bacteria	EH	4-phosphoerythronate dehydrogenase activity	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iYO844.BSU23070	2-Hacid_dh,2-Hacid_dh_C,ACT
SX1_k127_460965_2	1094980.Mpsy_2097	1.166e-17	95.0	COG0526@1|root,COG0785@1|root,arCOG01972@2157|Archaea,arCOG02404@2157|Archaea,2Y7HT@28890|Euryarchaeota,2NA19@224756|Methanomicrobia	224756|Methanomicrobia	O	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD
SX1_k127_4641886_0	269799.Gmet_2664	3.675e-87	299.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,42M55@68525|delta/epsilon subdivisions,2WIKM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
SX1_k127_4641886_1	1122236.KB905141_gene1334	2.003e-14	85.0	COG0438@1|root,COG0457@1|root,COG0859@1|root,COG4627@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,COG0859@2|Bacteria,COG4627@2|Bacteria,1RBR3@1224|Proteobacteria,2VSKQ@28216|Betaproteobacteria,2KP39@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
SX1_k127_4641886_2	1158338.JNLJ01000005_gene1717	2.369e-14	74.0	COG1522@1|root,COG1522@2|Bacteria,2G5DY@200783|Aquificae	200783|Aquificae	K	Winged helix-turn-helix DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
SX1_k127_4649163_2	1170562.Cal6303_1326	2.719e-05	57.0	COG2885@1|root,COG2885@2|Bacteria,1G2YF@1117|Cyanobacteria,1HMYH@1161|Nostocales	1117|Cyanobacteria	M	COGs COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)protein	-	-	-	ko:K02557,ko:K03286	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1,1.B.6	-	-	OmpA
SX1_k127_4649163_0	374847.Kcr_0115	2.266e-58	211.0	COG1042@1|root,arCOG01338@2157|Archaea	2157|Archaea	C	Acyl-CoA synthetase (NDP forming)	acdB	-	6.2.1.13	ko:K01905,ko:K18594,ko:K22224	ko00010,ko00620,ko00640,ko00720,ko01100,ko01120,map00010,map00620,map00640,map00720,map01100,map01120	-	R00229,R00920,R03157	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
SX1_k127_4649163_1	247490.KSU1_C1646	2.773e-25	114.0	COG0474@1|root,COG0474@2|Bacteria,2IXV7@203682|Planctomycetes	203682|Planctomycetes	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,SBP_bac_1
SX1_k127_4656820_1	344747.PM8797T_29268	2.342e-24	106.0	COG2120@1|root,COG2120@2|Bacteria,2IZ27@203682|Planctomycetes	203682|Planctomycetes	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
SX1_k127_4656820_0	1280952.HJA_05892	1.143e-110	370.0	COG4948@1|root,COG4948@2|Bacteria,1MU8R@1224|Proteobacteria,2TSS4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the mandelate racemase muconate lactonizing enzyme family	-	-	5.1.1.20,5.5.1.1	ko:K01856,ko:K19802	ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220	M00568	R05300,R05390,R06989,R08116,R09229,R10938	RC00903,RC01038,RC01108,RC01321,RC01356,RC03309	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
SX1_k127_4656820_2	158190.SpiGrapes_2743	7.203e-13	71.0	COG2211@1|root,COG2211@2|Bacteria,2JAUS@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX1_k127_4670010_8	880073.Calab_2562	1.04e-06	63.0	COG1520@1|root,COG4254@1|root,COG1520@2|Bacteria,COG4254@2|Bacteria	2|Bacteria	UW	PFAM FecR protein	-	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,SLH,SprB,VCBS
SX1_k127_4670010_2	1343739.PAP_10275	3.292e-109	365.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,242UY@183968|Thermococci	183968|Thermococci	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Intein_splicing,LAGLIDADG_3,Rad51
SX1_k127_4670010_7	1123502.AQXD01000002_gene300	3.581e-13	74.0	COG2018@1|root,COG2018@2|Bacteria,1RIQC@1224|Proteobacteria,1S65Z@1236|Gammaproteobacteria,1X7KJ@135614|Xanthomonadales	135614|Xanthomonadales	S	Roadblock/LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
SX1_k127_4670010_5	944547.ABLL_1068	9.75e-21	106.0	COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,42MNB@68525|delta/epsilon subdivisions,2YMKW@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
SX1_k127_4670010_4	868131.MSWAN_0476	6.089e-87	299.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTAH@28890|Euryarchaeota,23NWV@183925|Methanobacteria	183925|Methanobacteria	O	TIGRFAM hydrogenase expression formation protein HypE	-	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
SX1_k127_4670010_9	641524.ADICYQ_4331	8.687e-05	55.0	COG3419@1|root,COG3419@2|Bacteria,4NGV9@976|Bacteroidetes,47MMR@768503|Cytophagia	976|Bacteroidetes	NU	Tfp pilus assembly protein tip-associated adhesin	-	-	-	-	-	-	-	-	-	-	-	-	PQQ,PQQ_2
SX1_k127_4670010_0	264732.Moth_0607	0.0	1046.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,247RW@186801|Clostridia,42F5B@68295|Thermoanaerobacterales	186801|Clostridia	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
SX1_k127_4670010_3	1267535.KB906767_gene2246	2.249e-105	355.0	COG0006@1|root,COG0006@2|Bacteria,3Y3I4@57723|Acidobacteria,2JIWQ@204432|Acidobacteriia	204432|Acidobacteriia	E	Metallopeptidase family M24	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
SX1_k127_4670010_1	877455.Metbo_0154	3.621e-212	698.0	COG0060@1|root,arCOG00807@2157|Archaea,2XTIX@28890|Euryarchaeota,23NJ4@183925|Methanobacteria	183925|Methanobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
SX1_k127_4670010_6	323848.Nmul_A2249	1.339e-20	92.0	COG3360@1|root,COG3360@2|Bacteria,1PW6C@1224|Proteobacteria,2VXDE@28216|Betaproteobacteria,373H6@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
SX1_k127_4726700_6	747365.Thena_1186	2.491e-19	99.0	COG2193@1|root,COG2193@2|Bacteria,1UR9J@1239|Firmicutes,24WAK@186801|Clostridia	186801|Clostridia	C	Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
SX1_k127_4726700_8	1121448.DGI_2857	2.923e-10	71.0	COG2193@1|root,COG2193@2|Bacteria,1RCW7@1224|Proteobacteria,42RB9@68525|delta/epsilon subdivisions,2WMPE@28221|Deltaproteobacteria,2MB1R@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex	bfr	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
SX1_k127_4726700_2	1437425.CSEC_0956	1.703e-51	201.0	2B54A@1|root,31A9I@2|Bacteria,2JFT9@204428|Chlamydiae	204428|Chlamydiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_4726700_4	218284.CCDN010000005_gene3337	2.577e-30	132.0	COG4221@1|root,COG4221@2|Bacteria,1TRHF@1239|Firmicutes,4HBXH@91061|Bacilli,1ZQ69@1386|Bacillus	91061|Bacilli	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SX1_k127_4726700_5	1243664.CAVL020000005_gene354	1.002e-21	96.0	COG0637@1|root,COG0637@2|Bacteria,1TP1A@1239|Firmicutes,4HC8X@91061|Bacilli,1ZC9J@1386|Bacillus	91061|Bacilli	S	Belongs to the HAD-like hydrolase superfamily. PhnX family	phnX	-	3.11.1.1	ko:K05306	ko00440,ko01100,ko01120,map00440,map01100,map01120	-	R00747	RC00368	ko00000,ko00001,ko01000	-	-	-	HAD_2
SX1_k127_4726700_7	1117108.PAALTS15_03722	1.797e-17	85.0	COG0637@1|root,COG0637@2|Bacteria,1TP1A@1239|Firmicutes,4HC8X@91061|Bacilli,26QXU@186822|Paenibacillaceae	91061|Bacilli	S	Belongs to the HAD-like hydrolase superfamily. PhnX family	phnX	-	3.11.1.1	ko:K05306	ko00440,ko01100,ko01120,map00440,map01100,map01120	-	R00747	RC00368	ko00000,ko00001,ko01000	-	-	-	HAD_2
SX1_k127_4726700_3	1449063.JMLS01000044_gene3761	6.092e-32	128.0	COG0637@1|root,COG0637@2|Bacteria,1TP1A@1239|Firmicutes,4HC8X@91061|Bacilli,26QXU@186822|Paenibacillaceae	91061|Bacilli	S	Belongs to the HAD-like hydrolase superfamily. PhnX family	phnX	-	3.11.1.1	ko:K05306	ko00440,ko01100,ko01120,map00440,map01100,map01120	-	R00747	RC00368	ko00000,ko00001,ko01000	-	-	-	HAD_2
SX1_k127_4726700_0	997884.HMPREF1068_00165	1.436e-92	334.0	2CC7E@1|root,2Z7WG@2|Bacteria,4PJEQ@976|Bacteroidetes,2FRJV@200643|Bacteroidia,4AQCA@815|Bacteroidaceae	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_4726700_1	880070.Cycma_3900	2.879e-52	196.0	COG0823@1|root,COG0823@2|Bacteria,4NQ0C@976|Bacteroidetes,47PP7@768503|Cytophagia	976|Bacteroidetes	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_4742778_0	397948.Cmaq_0938	1.207e-127	429.0	COG0480@1|root,arCOG01559@2157|Archaea,2XPV5@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
SX1_k127_4742778_1	444158.MmarC6_1645	1.58e-58	217.0	COG1244@1|root,arCOG01360@2157|Archaea,2XT5Q@28890|Euryarchaeota,23QEG@183939|Methanococci	183939|Methanococci	S	SMART Elongator protein 3 MiaB NifB	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K06936	-	-	-	-	ko00000	-	-	-	Radical_SAM
SX1_k127_4742778_2	192952.MM_1292	7.375e-40	169.0	COG1549@1|root,arCOG00990@2157|Archaea,2XT9W@28890|Euryarchaeota,2N990@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM PUA domain containing protein	-	-	2.6.1.97	ko:K07557	-	-	-	-	ko00000,ko01000	-	-	-	PUA,TGT,TGT_C2
SX1_k127_4750178_2	316274.Haur_0876	3.522e-24	107.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,Polyketide_cyc2
SX1_k127_4750178_0	1379698.RBG1_1C00001G0253	1.191e-89	323.0	COG4191@1|root,COG4191@2|Bacteria,2NP93@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1
SX1_k127_4750178_4	192952.MM_3073	1.657e-06	59.0	COG4870@1|root,arCOG02498@1|root,arCOG02501@1|root,arCOG02542@1|root,arCOG02498@2157|Archaea,arCOG02501@2157|Archaea,arCOG02542@2157|Archaea,arCOG03607@2157|Archaea,2XWQ1@28890|Euryarchaeota,2NAG9@224756|Methanomicrobia	224756|Methanomicrobia	O	Papain family cysteine protease	-	-	-	-	-	-	-	-	-	-	-	-	NosD,PKD,Peptidase_C1
SX1_k127_4750178_3	46681.XP_001735948.1	1.373e-06	57.0	COG1100@1|root,KOG0087@2759|Eukaryota,3XFEK@554915|Amoebozoa	554915|Amoebozoa	U	Rab subfamily of small GTPases	-	-	-	-	-	-	-	-	-	-	-	-	Ras
SX1_k127_4750178_1	589924.Ferp_1301	4.456e-46	171.0	COG1720@1|root,arCOG00761@2157|Archaea,2XY3D@28890|Euryarchaeota,246RS@183980|Archaeoglobi	183980|Archaeoglobi	S	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
SX1_k127_4752134_1	1343739.PAP_06540	4.94e-39	151.0	COG2108@1|root,arCOG00932@2157|Archaea,2XU78@28890|Euryarchaeota,243PN@183968|Thermococci	183968|Thermococci	S	4Fe-4S single cluster domain	-	-	-	ko:K07129	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM
SX1_k127_4752134_2	415426.Hbut_0054	1.426e-34	144.0	COG1405@1|root,arCOG01981@2157|Archaea,2XQ1T@28889|Crenarchaeota	28889|Crenarchaeota	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
SX1_k127_4752134_0	529709.PYCH_04230	2.651e-173	556.0	COG1690@1|root,arCOG04246@2157|Archaea,2XTIC@28890|Euryarchaeota,24310@183968|Thermococci	183968|Thermococci	J	tRNA-splicing ligase that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs	rtcB	GO:0000166,GO:0000394,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003972,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0017076,GO:0019001,GO:0019002,GO:0030145,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901363	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Intein_splicing,LAGLIDADG_3,RtcB
SX1_k127_4752134_3	7739.XP_002607118.1	4.804e-22	100.0	COG1371@1|root,KOG4528@2759|Eukaryota,39U2I@33154|Opisthokonta,3BD8T@33208|Metazoa,3CWE8@33213|Bilateria,482Z7@7711|Chordata	33208|Metazoa	S	tRNA splicing, via endonucleolytic cleavage and ligation	ZBTB8OS	GO:0000394,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0007275,GO:0007399,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0010720,GO:0010975,GO:0010976,GO:0016070,GO:0022008,GO:0030154,GO:0031344,GO:0031346,GO:0031974,GO:0031981,GO:0032101,GO:0032103,GO:0032501,GO:0032502,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0045595,GO:0045597,GO:0045664,GO:0045666,GO:0046483,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0048679,GO:0048680,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050767,GO:0050769,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0051128,GO:0051130,GO:0051239,GO:0051240,GO:0051960,GO:0051962,GO:0060284,GO:0065007,GO:0070013,GO:0070570,GO:0070572,GO:0071704,GO:0072669,GO:0080134,GO:0080135,GO:0090304,GO:0120035,GO:1901360,GO:1903034,GO:1903036,GO:2000026	-	-	-	-	-	-	-	-	-	-	Archease
SX1_k127_4752134_4	768672.Desfe_0755	1.288e-21	104.0	COG4720@1|root,arCOG05752@2157|Archaea,2XQ9C@28889|Crenarchaeota	28889|Crenarchaeota	S	ECF-type riboflavin transporter, S component	-	-	-	-	-	-	-	-	-	-	-	-	ECF-ribofla_trS
SX1_k127_4752134_5	179408.Osc7112_4859	2.491e-14	84.0	COG1413@1|root,COG1413@2|Bacteria,1G233@1117|Cyanobacteria,1H7RE@1150|Oscillatoriales	1117|Cyanobacteria	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
SX1_k127_4752134_7	994573.T472_0207070	0.0002207	45.0	COG0574@1|root,COG0574@2|Bacteria,1TW0W@1239|Firmicutes,248VM@186801|Clostridia,36GX2@31979|Clostridiaceae	186801|Clostridia	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PPDK_N,Response_reg
SX1_k127_4752134_6	1074488.AGBX01000001_gene963	6.963e-08	55.0	COG0334@1|root,COG0334@2|Bacteria,2GKXG@201174|Actinobacteria,4FBYG@85020|Dermabacteraceae	201174|Actinobacteria	E	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	gdhA	GO:0003674,GO:0003824,GO:0004353,GO:0004354,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	-	R00248	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
SX1_k127_4764825_0	1033737.CAEV01000072_gene411	7.523e-44	166.0	COG2320@1|root,COG2320@2|Bacteria,1V3IB@1239|Firmicutes,24F56@186801|Clostridia,36VN9@31979|Clostridiaceae	186801|Clostridia	S	GrpB protein	-	-	-	-	-	-	-	-	-	-	-	-	GrpB
SX1_k127_4768737_0	877455.Metbo_0185	1.466e-08	64.0	COG1522@1|root,arCOG01580@2157|Archaea,2XZQD@28890|Euryarchaeota,23PPJ@183925|Methanobacteria	183925|Methanobacteria	K	helix_turn_helix ASNC type	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
SX1_k127_4769500_3	1336243.JAEA01000005_gene1344	3.248e-15	83.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	yjaU	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Hydrolase_4
SX1_k127_4769500_1	536227.CcarbDRAFT_5143	3.243e-57	217.0	COG0624@1|root,COG0624@2|Bacteria,1TRHJ@1239|Firmicutes,24DN5@186801|Clostridia,36GMW@31979|Clostridiaceae	186801|Clostridia	E	Psort location Cytoplasmic, score 7.50	-	-	-	ko:K13049	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
SX1_k127_4769500_0	706587.Desti_3979	1.39e-59	214.0	COG0461@1|root,COG0461@2|Bacteria	2|Bacteria	F	orotate phosphoribosyltransferase activity	pyrE	-	2.4.2.10,4.1.1.23	ko:K00762,ko:K01591,ko:K13421	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00051	R00965,R01870,R08231	RC00063,RC00409,RC00611	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU15560	OMPdecase,Pribosyltran
SX1_k127_4769500_2	742741.HMPREF9475_01614	2.657e-51	187.0	COG4725@1|root,COG4725@2|Bacteria,1V5QV@1239|Firmicutes,24IYS@186801|Clostridia,2242H@1506553|Lachnoclostridium	186801|Clostridia	KT	MT-A70	-	-	-	-	-	-	-	-	-	-	-	-	MT-A70
SX1_k127_4777851_2	945713.IALB_3090	3.947e-22	101.0	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlA	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
SX1_k127_4777851_0	1191523.MROS_1829	1.283e-83	290.0	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlA	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
SX1_k127_4777851_1	1405.DJ92_3167	6.582e-68	248.0	COG1541@1|root,COG1541@2|Bacteria,1UYWT@1239|Firmicutes,4HD2R@91061|Bacilli,1ZEJB@1386|Bacillus	91061|Bacilli	H	Coenzyme F390 synthetase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
SX1_k127_4777851_3	9031.ENSGALP00000042275	3.619e-20	95.0	COG2453@1|root,KOG1720@2759|Eukaryota,3A0SJ@33154|Opisthokonta,3BQPQ@33208|Metazoa,3D771@33213|Bilateria,47ZA4@7711|Chordata,491DH@7742|Vertebrata,4GUTF@8782|Aves	33208|Metazoa	V	dual specificity protein phosphatase	DUSP23	GO:0003674,GO:0003824,GO:0004721,GO:0004722,GO:0004725,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008138,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0031974,GO:0031981,GO:0035335,GO:0036211,GO:0042578,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0070013,GO:0071704,GO:0140096,GO:1901564	3.1.3.16,3.1.3.48	ko:K14165	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	DSPc
SX1_k127_4782540_1	4959.XP_456433.2	1.25e-27	119.0	KOG0092@1|root,KOG0092@2759|Eukaryota,3A499@33154|Opisthokonta,3P3JI@4751|Fungi,3QV96@4890|Ascomycota,3RUXK@4891|Saccharomycetes,47CT8@766764|Debaryomycetaceae	4751|Fungi	U	Signal recognition particle receptor beta subunit	YPT53	GO:0000166,GO:0000322,GO:0000323,GO:0000324,GO:0000329,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005774,GO:0006996,GO:0007030,GO:0008150,GO:0009987,GO:0010256,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0031090,GO:0036094,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0071840,GO:0097159,GO:0098588,GO:0098805,GO:0098852,GO:1901265,GO:1901363	-	ko:K07976	-	-	-	-	ko00000,ko04031	-	-	-	Ras
SX1_k127_4782540_4	675812.VHA_002226	0.0004438	47.0	COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,1SCA2@1236|Gammaproteobacteria,1XYF2@135623|Vibrionales	135623|Vibrionales	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	-	-	-	ko:K03676	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
SX1_k127_4782540_2	243232.MJ_0739	1.204e-08	62.0	COG1719@1|root,arCOG01688@2157|Archaea,2XXRB@28890|Euryarchaeota,23QWV@183939|Methanococci	183939|Methanococci	S	PFAM 4-vinyl reductase, 4VR	-	-	-	ko:K07013	-	-	-	-	ko00000	-	-	-	DUF2507,V4R
SX1_k127_4782540_3	272844.PAB7359	4.771e-07	55.0	COG1522@1|root,arCOG01117@2157|Archaea,2Y1MB@28890|Euryarchaeota,244GZ@183968|Thermococci	183968|Thermococci	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
SX1_k127_4782540_0	263820.PTO1069	6.884e-29	119.0	COG0599@1|root,arCOG02148@2157|Archaea,2Y01N@28890|Euryarchaeota,242D9@183967|Thermoplasmata	183967|Thermoplasmata	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
SX1_k127_4799519_1	1459636.NTE_00139	3.004e-08	65.0	COG0438@1|root,arCOG04796@2157|Archaea,41T9D@651137|Thaumarchaeota	2157|Archaea	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
SX1_k127_4799519_0	386456.JQKN01000007_gene3234	5.511e-253	803.0	COG1152@1|root,arCOG02428@2157|Archaea,2XTBY@28890|Euryarchaeota	28890|Euryarchaeota	C	Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase	cdhA	GO:0000302,GO:0003674,GO:0003824,GO:0004601,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016661,GO:0016684,GO:0042221,GO:0042493,GO:0042542,GO:0046677,GO:0050418,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748	1.2.7.4	ko:K00192	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00422	R07157	RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_7,Fer4_9,Prismane
SX1_k127_4804007_2	368408.Tpen_1486	4.529e-62	229.0	COG3839@1|root,arCOG00175@2157|Archaea,2XPVK@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM ABC transporter related	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE
SX1_k127_4804007_12	397945.Aave_1880	1.089e-07	61.0	COG1392@1|root,COG1392@2|Bacteria,1R4SP@1224|Proteobacteria,2VKF1@28216|Betaproteobacteria,4AB1P@80864|Comamonadaceae	28216|Betaproteobacteria	P	phosphate transport regulator	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
SX1_k127_4804007_5	1094980.Mpsy_2011	8.402e-39	158.0	COG0306@1|root,arCOG02267@2157|Archaea,2XSUU@28890|Euryarchaeota,2N9TT@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM phosphate transporter	pitA	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
SX1_k127_4804007_13	443254.Marpi_0064	0.0006424	50.0	COG1392@1|root,COG1392@2|Bacteria,2GD3E@200918|Thermotogae	200918|Thermotogae	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
SX1_k127_4804007_10	647113.Metok_0411	9.798e-13	74.0	COG2018@1|root,arCOG02603@2157|Archaea,2XY6Z@28890|Euryarchaeota,23R2D@183939|Methanococci	183939|Methanococci	S	PFAM Roadblock LC7 family protein	-	GO:0001101,GO:0003674,GO:0005085,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0009719,GO:0009966,GO:0009967,GO:0009987,GO:0010033,GO:0010243,GO:0010646,GO:0010647,GO:0019899,GO:0023051,GO:0023056,GO:0032006,GO:0032008,GO:0032947,GO:0042221,GO:0043200,GO:0044464,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051020,GO:0051716,GO:0065007,GO:0065009,GO:0070887,GO:0071229,GO:0071230,GO:0071310,GO:0071417,GO:0071495,GO:0098772,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
SX1_k127_4804007_3	768710.DesyoDRAFT_2543	1.283e-46	173.0	COG0655@1|root,COG0655@2|Bacteria,1TT84@1239|Firmicutes,248W0@186801|Clostridia,261MC@186807|Peptococcaceae	186801|Clostridia	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
SX1_k127_4804007_6	926561.KB900617_gene1266	1.396e-28	124.0	COG0584@1|root,COG0584@2|Bacteria,1V3W4@1239|Firmicutes,24AVJ@186801|Clostridia,3WBR3@53433|Halanaerobiales	186801|Clostridia	C	PFAM Glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD,GPDPase_memb
SX1_k127_4804007_4	1054217.TALC_01013	2.089e-41	160.0	COG2101@1|root,arCOG01764@2157|Archaea,2XTTR@28890|Euryarchaeota,241NQ@183967|Thermoplasmata	183967|Thermoplasmata	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	tbp	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
SX1_k127_4804007_11	157072.XP_008863371.1	9.041e-11	74.0	KOG3886@1|root,KOG3886@2759|Eukaryota	2759|Eukaryota	T	interleukin-4 receptor binding	RRAGB	GO:0000003,GO:0000166,GO:0000322,GO:0000323,GO:0000324,GO:0000329,GO:0001101,GO:0001558,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005764,GO:0005768,GO:0005770,GO:0005773,GO:0005774,GO:0005829,GO:0006139,GO:0006325,GO:0006342,GO:0006348,GO:0006351,GO:0006355,GO:0006360,GO:0006383,GO:0006464,GO:0006725,GO:0006807,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006995,GO:0006996,GO:0007049,GO:0007050,GO:0007154,GO:0007165,GO:0007264,GO:0007275,GO:0007568,GO:0008104,GO:0008150,GO:0008152,GO:0008219,GO:0008340,GO:0009058,GO:0009059,GO:0009267,GO:0009605,GO:0009719,GO:0009889,GO:0009890,GO:0009892,GO:0009894,GO:0009895,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0009991,GO:0010008,GO:0010033,GO:0010243,GO:0010259,GO:0010467,GO:0010468,GO:0010506,GO:0010507,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0010646,GO:0010647,GO:0010648,GO:0012505,GO:0015698,GO:0016020,GO:0016032,GO:0016043,GO:0016070,GO:0016241,GO:0016458,GO:0016462,GO:0016567,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0018130,GO:0019001,GO:0019048,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0019899,GO:0022402,GO:0023051,GO:0023052,GO:0023056,GO:0023057,GO:0030307,GO:0031090,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031329,GO:0031330,GO:0031410,GO:0031625,GO:0031667,GO:0031668,GO:0031669,GO:0031902,GO:0031982,GO:0032006,GO:0032007,GO:0032008,GO:0032446,GO:0032501,GO:0032502,GO:0032504,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032774,GO:0032991,GO:0033036,GO:0033365,GO:0033554,GO:0034198,GO:0034448,GO:0034613,GO:0034641,GO:0034645,GO:0034654,GO:0035556,GO:0035639,GO:0035821,GO:0036094,GO:0036211,GO:0040008,GO:0040014,GO:0040018,GO:0040029,GO:0042221,GO:0042268,GO:0042594,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043170,GO:0043200,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043562,GO:0044003,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044389,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044437,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0045786,GO:0045814,GO:0045892,GO:0045919,GO:0045927,GO:0045934,GO:0046483,GO:0046982,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0048638,GO:0048639,GO:0048856,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051020,GO:0051094,GO:0051128,GO:0051171,GO:0051172,GO:0051179,GO:0051219,GO:0051234,GO:0051239,GO:0051240,GO:0051252,GO:0051253,GO:0051276,GO:0051641,GO:0051701,GO:0051704,GO:0051716,GO:0051726,GO:0051817,GO:0060255,GO:0065007,GO:0070647,GO:0070727,GO:0070887,GO:0071229,GO:0071230,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0071840,GO:0072657,GO:0072665,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0097708,GO:0098588,GO:0098796,GO:0098805,GO:0098852,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901576,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902532,GO:1902533,GO:1902679,GO:1903432,GO:1903506,GO:1903507,GO:1903778,GO:1904262,GO:1904263,GO:1990131,GO:1990253,GO:1990928,GO:2000112,GO:2000113,GO:2001141	-	ko:K16185	ko04140,ko04150,map04140,map04150	-	-	-	ko00000,ko00001	-	-	-	Gtr1_RagA
SX1_k127_4804007_9	28583.AMAG_07692T0	3.843e-15	83.0	KOG0092@1|root,KOG0092@2759|Eukaryota,38HB3@33154|Opisthokonta,3NY6F@4751|Fungi	4751|Fungi	U	vacuolar protein sorting-associated protein	VPS21	GO:0000011,GO:0003674,GO:0003824,GO:0003924,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0005768,GO:0005769,GO:0005770,GO:0005886,GO:0006605,GO:0006623,GO:0006810,GO:0006886,GO:0006892,GO:0006895,GO:0006897,GO:0006914,GO:0006996,GO:0007032,GO:0007033,GO:0007034,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0010256,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0016197,GO:0016236,GO:0016462,GO:0016482,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019867,GO:0022411,GO:0022607,GO:0030139,GO:0031090,GO:0031410,GO:0031966,GO:0031967,GO:0031968,GO:0031975,GO:0031982,GO:0032509,GO:0032511,GO:0033036,GO:0033365,GO:0034613,GO:0036010,GO:0036257,GO:0036258,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044237,GO:0044248,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0045324,GO:0046907,GO:0048193,GO:0048308,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0061709,GO:0061912,GO:0061919,GO:0070727,GO:0070925,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0071985,GO:0072594,GO:0072665,GO:0072666,GO:0097708,GO:0098588,GO:0098657,GO:0098805,GO:1903008	-	ko:K07889,ko:K07976	ko04014,ko04144,ko04145,ko04962,ko05146,ko05152,map04014,map04144,map04145,map04962,map05146,map05152	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
SX1_k127_4804007_8	523841.HFX_1697	3.909e-19	102.0	COG0467@1|root,arCOG01178@2157|Archaea,2Y0GM@28890|Euryarchaeota	28890|Euryarchaeota	T	PFAM GvpD gas vesicle	gvpD	-	-	-	-	-	-	-	-	-	-	-	GvpD
SX1_k127_4804007_7	1121334.KB911070_gene1379	2.917e-28	119.0	COG3862@1|root,COG3862@2|Bacteria,1VA4U@1239|Firmicutes,24MN9@186801|Clostridia,3WKTY@541000|Ruminococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1667)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1667
SX1_k127_4804007_0	1158607.UAU_00136	8.796e-147	476.0	COG0446@1|root,COG0446@2|Bacteria,1TQH5@1239|Firmicutes,4HE68@91061|Bacilli,4B14D@81852|Enterococcaceae	91061|Bacilli	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4,Fer2_BFD,Pyr_redox_2,Pyr_redox_3
SX1_k127_4804007_1	1209989.TepiRe1_0625	5.135e-138	454.0	COG0579@1|root,COG1251@1|root,COG0579@2|Bacteria,COG1251@2|Bacteria,1TRDH@1239|Firmicutes,248IK@186801|Clostridia,42EZS@68295|Thermoanaerobacterales	186801|Clostridia	C	BFD domain protein 2Fe-2S -binding domain protein	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	BON,DAO,Fer2_BFD
SX1_k127_4806912_0	224325.AF_2257	5.404e-11	69.0	COG2232@1|root,arCOG01595@2157|Archaea,2XXHX@28890|Euryarchaeota,2460P@183980|Archaeoglobi	183980|Archaeoglobi	S	ATP-grasp domain	-	-	-	ko:K06913	-	-	-	-	ko00000	-	-	-	ATP-grasp_3
SX1_k127_4806912_1	107636.JQNK01000009_gene1399	1.222e-07	63.0	COG0286@1|root,COG1002@1|root,COG0286@2|Bacteria,COG1002@2|Bacteria,1R6GX@1224|Proteobacteria	1224|Proteobacteria	V	site-specific DNA-methyltransferase (adenine-specific) activity	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
SX1_k127_4827241_0	1191523.MROS_1048	1.129e-17	98.0	COG0286@1|root,COG1002@1|root,COG0286@2|Bacteria,COG1002@2|Bacteria	2|Bacteria	V	DNA modification	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_Mtase
SX1_k127_4838950_4	69014.TK1633	4.132e-52	189.0	COG2123@1|root,arCOG01574@2157|Archaea,2XWTK@28890|Euryarchaeota,2433E@183968|Thermococci	183968|Thermococci	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site	rrp42	GO:0000177,GO:0000178,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0017091,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354	-	ko:K12589	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
SX1_k127_4838950_0	529709.PYCH_03850	5.329e-80	277.0	COG0689@1|root,arCOG01575@2157|Archaea,2XVHI@28890|Euryarchaeota,242PZ@183968|Thermococci	183968|Thermococci	J	Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails	rrp41	GO:0000177,GO:0000178,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575,GO:1902494,GO:1905354	-	ko:K11600	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
SX1_k127_4838950_5	1151117.AJLF01000002_gene85	4.162e-48	181.0	COG1097@1|root,arCOG00678@2157|Archaea,2XWEN@28890|Euryarchaeota,242IU@183968|Thermococci	183968|Thermococci	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome	rrp4	GO:0000178,GO:0000288,GO:0000291,GO:0000459,GO:0000460,GO:0000466,GO:0000467,GO:0000469,GO:0000956,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006364,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016180,GO:0019222,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0031126,GO:0032991,GO:0034470,GO:0034472,GO:0034475,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043144,GO:0043170,GO:0043628,GO:0043928,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071034,GO:0071043,GO:0071051,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354	-	ko:K03679	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,KH_6
SX1_k127_4838950_3	644281.MFS40622_1572	2.994e-52	194.0	COG1500@1|root,arCOG04187@2157|Archaea,2XTNH@28890|Euryarchaeota,23QMS@183939|Methanococci	183939|Methanococci	J	PFAM Ribosome maturation protein	-	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	ko:K14574	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	SBDS,SBDS_C
SX1_k127_4838950_2	224325.AF_0490	5.985e-59	213.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,246RW@183980|Archaeoglobi	183980|Archaeoglobi	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
SX1_k127_4838950_6	523850.TON_1485	8.07e-30	128.0	COG4044@1|root,arCOG04612@2157|Archaea,2XT7E@28890|Euryarchaeota,242Y4@183968|Thermococci	183968|Thermococci	S	Uncharacterized protein conserved in archaea (DUF2110)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2110
SX1_k127_4838950_1	224325.AF_1752	9.536e-76	262.0	COG1070@1|root,arCOG00025@2157|Archaea,2Y7I2@28890|Euryarchaeota	28890|Euryarchaeota	G	Belongs to the FGGY kinase family	-	-	2.7.1.17,2.7.1.53	ko:K00854,ko:K00880	ko00040,ko00053,ko01100,map00040,map00053,map01100	M00014	R01639,R01901,R07127	RC00002,RC00017,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
SX1_k127_4839190_1	1089553.Tph_c08020	6.824e-78	272.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,42EN1@68295|Thermoanaerobacterales	186801|Clostridia	C	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
SX1_k127_4839190_3	204669.Acid345_0642	3.768e-66	235.0	COG1028@1|root,COG1028@2|Bacteria,3Y2YB@57723|Acidobacteria,2JII9@204432|Acidobacteriia	204432|Acidobacteriia	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
SX1_k127_4839190_2	1173026.Glo7428_1510	4.36e-72	257.0	2BWJ3@1|root,2Z7IQ@2|Bacteria,1G3WZ@1117|Cyanobacteria	1117|Cyanobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
SX1_k127_4839190_5	1034769.KB910518_gene3761	4.433e-18	92.0	COG0454@1|root,COG0456@2|Bacteria,1VHPQ@1239|Firmicutes,4HM3W@91061|Bacilli,26XQB@186822|Paenibacillaceae	91061|Bacilli	K	Acetyltransferase (GNAT) family	yrkN3	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_7
SX1_k127_4839190_4	760011.Spico_1042	4.846e-56	205.0	COG1028@1|root,COG1028@2|Bacteria,2J8GM@203691|Spirochaetes	203691|Spirochaetes	IQ	COGs COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase)	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SX1_k127_4839190_0	760011.Spico_1044	3.084e-94	321.0	COG0006@1|root,COG0673@1|root,COG0006@2|Bacteria,COG0673@2|Bacteria,2J6T7@203691|Spirochaetes	203691|Spirochaetes	E	Oxidoreductase family, C-terminal alpha beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX1_k127_4844414_0	679926.Mpet_1095	4.732e-144	475.0	COG0209@1|root,arCOG04276@2157|Archaea,2XUBW@28890|Euryarchaeota,2NAJJ@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
SX1_k127_4852189_2	797210.Halxa_3945	6.994e-48	180.0	COG0863@1|root,arCOG00115@2157|Archaea,2XXQ9@28890|Euryarchaeota,23VYI@183963|Halobacteria	183963|Halobacteria	L	COG0863 DNA modification methylase	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
SX1_k127_4852189_1	509191.AEDB02000094_gene4210	1.441e-49	184.0	COG5418@1|root,COG5418@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF523
SX1_k127_4852189_0	1499967.BAYZ01000156_gene556	8.83e-57	205.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568,ko:K20444	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_trans_1_4,Glycos_transf_2,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
SX1_k127_4852189_3	86416.Clopa_3000	2.101e-08	59.0	COG0491@1|root,COG0491@2|Bacteria,1V2VR@1239|Firmicutes,25B40@186801|Clostridia,36W8Q@31979|Clostridiaceae	186801|Clostridia	S	PFAM Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SX1_k127_4854449_0	762984.HMPREF9445_02692	8.255e-13	72.0	COG4704@1|root,COG4704@2|Bacteria,4NUMP@976|Bacteroidetes,2FQTK@200643|Bacteroidia	976|Bacteroidetes	S	Fibrobacter succinogenes major domain (Fib_succ_major)	-	-	-	-	-	-	-	-	-	-	-	-	Fib_succ_major,Mfa_like_1
SX1_k127_4877539_0	351627.Csac_2202	2.614e-127	430.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,42EQB@68295|Thermoanaerobacterales	186801|Clostridia	P	ABC transporter, transmembrane region	-	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SX1_k127_4877539_1	351627.Csac_2201	1.091e-77	291.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,42FVZ@68295|Thermoanaerobacterales	186801|Clostridia	P	ABC transporter, transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SX1_k127_4881947_0	411154.GFO_2878	0.0001527	56.0	COG4932@1|root,COG4932@2|Bacteria,4NQ5A@976|Bacteroidetes,1IJZ3@117743|Flavobacteriia	976|Bacteroidetes	M	FG-GAP repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,FG-GAP,VCBS
SX1_k127_4912235_8	27923.ML085028a-PA	1.146e-15	85.0	KOG0073@1|root,KOG0073@2759|Eukaryota,39K0E@33154|Opisthokonta,3BDBM@33208|Metazoa	33208|Metazoa	U	GTP binding	ARL2	GO:0000003,GO:0000132,GO:0000166,GO:0000226,GO:0000278,GO:0000281,GO:0000910,GO:0001505,GO:0001882,GO:0001883,GO:0002791,GO:0003006,GO:0003674,GO:0003824,GO:0003924,GO:0004857,GO:0005095,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005759,GO:0005794,GO:0005813,GO:0005815,GO:0005818,GO:0005819,GO:0005829,GO:0005856,GO:0005886,GO:0005912,GO:0005924,GO:0005925,GO:0006810,GO:0006811,GO:0006812,GO:0006836,GO:0006897,GO:0006996,GO:0007010,GO:0007017,GO:0007021,GO:0007043,GO:0007049,GO:0007098,GO:0007154,GO:0007163,GO:0007267,GO:0007268,GO:0007269,GO:0007275,GO:0007399,GO:0007405,GO:0007548,GO:0008104,GO:0008150,GO:0008283,GO:0008356,GO:0009790,GO:0009792,GO:0009914,GO:0009987,GO:0010638,GO:0010646,GO:0010810,GO:0010811,GO:0010817,GO:0012505,GO:0015630,GO:0015695,GO:0015696,GO:0015870,GO:0015893,GO:0016020,GO:0016043,GO:0016192,GO:0016328,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0017145,GO:0019001,GO:0019003,GO:0022008,GO:0022402,GO:0022414,GO:0022607,GO:0023051,GO:0023052,GO:0023061,GO:0030010,GO:0030054,GO:0030055,GO:0030154,GO:0030155,GO:0030234,GO:0030540,GO:0030695,GO:0030865,GO:0031023,GO:0031110,GO:0031112,GO:0031113,GO:0031116,GO:0031122,GO:0031334,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0031981,GO:0032271,GO:0032273,GO:0032501,GO:0032502,GO:0032507,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032879,GO:0032880,GO:0032886,GO:0032940,GO:0033036,GO:0033043,GO:0033365,GO:0034260,GO:0034329,GO:0034330,GO:0034332,GO:0034333,GO:0034504,GO:0034613,GO:0034622,GO:0035639,GO:0036094,GO:0036445,GO:0036465,GO:0040001,GO:0042221,GO:0042493,GO:0043086,GO:0043087,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043254,GO:0043297,GO:0043622,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044092,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044429,GO:0044430,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0045165,GO:0045185,GO:0045196,GO:0045216,GO:0045785,GO:0046660,GO:0046883,GO:0046903,GO:0048103,GO:0048488,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048608,GO:0048699,GO:0048731,GO:0048806,GO:0048856,GO:0048869,GO:0050708,GO:0050789,GO:0050790,GO:0050794,GO:0050796,GO:0050896,GO:0051046,GO:0051049,GO:0051128,GO:0051130,GO:0051179,GO:0051223,GO:0051234,GO:0051235,GO:0051293,GO:0051294,GO:0051301,GO:0051336,GO:0051346,GO:0051457,GO:0051493,GO:0051495,GO:0051640,GO:0051641,GO:0051649,GO:0051651,GO:0051653,GO:0051656,GO:0055057,GO:0055059,GO:0060589,GO:0061351,GO:0061458,GO:0061640,GO:0065003,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070161,GO:0070201,GO:0070507,GO:0070727,GO:0070830,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072089,GO:0072595,GO:0090087,GO:0090276,GO:0097159,GO:0097367,GO:0097435,GO:0098657,GO:0098722,GO:0098772,GO:0098916,GO:0099003,GO:0099080,GO:0099504,GO:0099536,GO:0099537,GO:0099643,GO:1901265,GO:1901363,GO:1901374,GO:1902850,GO:1902903,GO:1902905,GO:1903047,GO:1903530	-	ko:K07943,ko:K21596	-	-	-	-	ko00000,ko03000,ko03036,ko04031	-	-	-	Arf
SX1_k127_4912235_2	216594.MMAR_3322	9.36e-101	338.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,233TJ@1762|Mycobacteriaceae	201174|Actinobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase	-	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
SX1_k127_4912235_4	1108045.GORHZ_125_00290	1.951e-58	216.0	COG1071@1|root,COG1071@2|Bacteria,2GK3W@201174|Actinobacteria,4GBU0@85026|Gordoniaceae	201174|Actinobacteria	C	Dehydrogenase E1 component	acoA	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
SX1_k127_4912235_3	1140003.I573_01527	1.327e-59	223.0	COG1228@1|root,COG1228@2|Bacteria,1TQQ0@1239|Firmicutes,4HDKW@91061|Bacilli,4B0RB@81852|Enterococcaceae	91061|Bacilli	Q	Amidohydrolase family	hutI	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
SX1_k127_4912235_7	880073.Calab_2378	1.186e-16	91.0	COG3153@1|root,COG3153@2|Bacteria,2NQXN@2323|unclassified Bacteria	2|Bacteria	K	Acetyltransferase (GNAT) domain	yhbS	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564	2.3.1.189,2.3.1.59,2.3.1.82	ko:K03824,ko:K04766,ko:K06889,ko:K09964,ko:K14658,ko:K15520,ko:K17840,ko:K18815	-	M00664	-	-	br01600,ko00000,ko00002,ko01000,ko01504	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7,Acetyltransf_9
SX1_k127_4912235_1	373903.Hore_21960	4.404e-131	452.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,3WB3A@53433|Halanaerobiales	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
SX1_k127_4912235_5	644966.Tmar_2073	8.477e-32	128.0	COG0328@1|root,COG0328@2|Bacteria,1VAJW@1239|Firmicutes,24NJ8@186801|Clostridia	186801|Clostridia	L	PFAM ribonuclease H	rnhA	-	3.1.26.4	ko:K03469,ko:K06864	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RVT_3
SX1_k127_4912235_0	439481.Aboo_0846	6.232e-132	433.0	COG0017@1|root,arCOG00407@2157|Archaea,2XTZJ@28890|Euryarchaeota,3F37W@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	class II (D K and N)	asnS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
SX1_k127_4923902_1	1236976.JCM16418_2962	1.365e-28	122.0	COG0673@1|root,COG0673@2|Bacteria,1TRCC@1239|Firmicutes,4HEB9@91061|Bacilli,26STK@186822|Paenibacillaceae	91061|Bacilli	S	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX1_k127_4923902_0	1443113.LC20_05099	1.81e-40	172.0	COG0286@1|root,COG0286@2|Bacteria	2|Bacteria	V	site-specific DNA-methyltransferase (adenine-specific) activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,N6_Mtase,TaqI_C
SX1_k127_4923902_6	1333523.L593_04590	7.999e-06	57.0	COG1522@1|root,arCOG01580@2157|Archaea,2XX5M@28890|Euryarchaeota,23VKV@183963|Halobacteria	183963|Halobacteria	K	COG1522 Transcriptional regulators	trh3	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_AsnC-type
SX1_k127_4923902_5	673860.AciM339_0679	5.507e-10	70.0	COG1522@1|root,arCOG01586@2157|Archaea,2Y6Z8@28890|Euryarchaeota,3F2Z8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
SX1_k127_4923902_3	161156.JQKW01000001_gene1452	1.009e-17	91.0	COG0558@1|root,COG0558@2|Bacteria,2GH4T@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
SX1_k127_4923902_2	323259.Mhun_1259	2.737e-27	120.0	COG1339@1|root,arCOG01904@2157|Archaea,2XTFW@28890|Euryarchaeota,2N9NG@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN)	ribK	-	2.7.1.161	ko:K07732	ko00740,ko01100,map00740,map01100	-	R08574	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CTP-dep_RFKase,HTH_24,MarR
SX1_k127_4923902_4	186497.PF0985	2.736e-13	74.0	COG2178@1|root,arCOG04318@2157|Archaea,2XYD0@28890|Euryarchaeota,242PY@183968|Thermococci	183968|Thermococci	J	Translin family	-	-	-	ko:K07477	-	-	-	-	ko00000	-	-	-	Translin
SX1_k127_4929939_2	913865.DOT_0943	3.441e-07	56.0	COG0826@1|root,COG0826@2|Bacteria	2|Bacteria	O	peptidase U32	-	-	-	-	-	-	-	-	-	-	-	-	DUF3656,DUF3795,Peptidase_U32
SX1_k127_4929939_0	536227.CcarbDRAFT_4800	2.589e-129	423.0	COG2768@1|root,COG2768@2|Bacteria,1TQAW@1239|Firmicutes,247IS@186801|Clostridia,36EQY@31979|Clostridiaceae	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4
SX1_k127_4929939_1	1173020.Cha6605_0072	2.176e-11	75.0	COG0451@1|root,COG0451@2|Bacteria,1G8XW@1117|Cyanobacteria	1117|Cyanobacteria	M	Male sterility protein	-	-	-	-	-	-	-	-	-	-	-	-	3Beta_HSD,Epimerase
SX1_k127_4951195_1	273068.TTE2216	2.111e-15	85.0	COG0546@1|root,COG0546@2|Bacteria,1TPPZ@1239|Firmicutes,24GK6@186801|Clostridia,42GMH@68295|Thermoanaerobacterales	186801|Clostridia	S	HAD-superfamily hydrolase, subfamily IA	Gph	-	3.1.3.18,3.6.1.1	ko:K01091,ko:K06019	ko00190,ko00630,ko01100,ko01110,ko01130,map00190,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
SX1_k127_4951195_0	70601.3258136	3.495e-45	180.0	COG0731@1|root,arCOG04174@2157|Archaea,2XSTF@28890|Euryarchaeota,24362@183968|Thermococci	183968|Thermococci	C	Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe)	taw1	-	4.1.3.44	ko:K15449	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,Wyosine_form
SX1_k127_4951195_2	1330700.JQNC01000003_gene181	1.4e-12	78.0	COG0813@1|root,COG0813@2|Bacteria,1WIF6@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	TIGRFAM purine-nucleoside phosphorylase, family 1 (deoD)	-	-	2.4.2.1	ko:K03784	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
SX1_k127_4951195_3	243232.MJ_1398	4.586e-06	58.0	COG3398@1|root,arCOG02611@2157|Archaea,2XW64@28890|Euryarchaeota,23PZT@183939|Methanococci	183939|Methanococci	K	PFAM regulatory protein, ArsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
SX1_k127_495701_0	1047013.AQSP01000095_gene2303	1.603e-208	676.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX1_k127_495701_1	243231.GSU0751	3.15e-60	213.0	COG5423@1|root,COG5423@2|Bacteria,1N9C0@1224|Proteobacteria,42W42@68525|delta/epsilon subdivisions,2WR81@28221|Deltaproteobacteria,43TPZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Predicted metal-binding protein (DUF2284)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2284
SX1_k127_4957622_7	32051.SynWH7803_1510	0.0003533	51.0	COG0662@1|root,COG0662@2|Bacteria,1GRFS@1117|Cyanobacteria,1H0Z1@1129|Synechococcus	1117|Cyanobacteria	G	mannose-6-phosphate isomerase	-	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer
SX1_k127_4957622_4	666510.ASAC_1357	2.848e-07	56.0	COG5625@1|root,arCOG04189@2157|Archaea,2XQWI@28889|Crenarchaeota	28889|Crenarchaeota	K	HTH DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_4957622_1	633148.Tagg_0852	1.71e-42	160.0	COG0091@1|root,arCOG04098@2157|Archaea,2XQCP@28889|Crenarchaeota	28889|Crenarchaeota	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rpl22	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
SX1_k127_4957622_0	195522.BD01_2154	3.55e-45	175.0	COG0092@1|root,arCOG04097@2157|Archaea,2XTHR@28890|Euryarchaeota,243EH@183968|Thermococci	183968|Thermococci	J	Binds the lower part of the 30S subunit head	rps3	GO:0000702,GO:0002181,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003735,GO:0003824,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006281,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008534,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
SX1_k127_4957622_3	748449.Halha_0197	3.902e-08	57.0	COG0255@1|root,COG0255@2|Bacteria,1VEME@1239|Firmicutes,24QV1@186801|Clostridia,3WAX4@53433|Halanaerobiales	186801|Clostridia	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
SX1_k127_4957622_6	224719.Abm4_1268	0.0001034	49.0	COG1588@1|root,arCOG00784@2157|Archaea,2Y0EN@28890|Euryarchaeota,23PQP@183925|Methanobacteria	183925|Methanobacteria	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp1	-	3.1.26.5	ko:K03538	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	UPF0086
SX1_k127_4957622_2	439481.Aboo_1512	1.722e-31	126.0	COG0186@1|root,arCOG04096@2157|Archaea,2XYPE@28890|Euryarchaeota,3F2Q9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rps17	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
SX1_k127_4957622_5	436308.Nmar_0800	3.317e-05	47.0	COG0093@1|root,arCOG04095@2157|Archaea,41SHG@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rpl14	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
SX1_k127_4958130_4	647113.Metok_0125	2.005e-10	63.0	COG2122@1|root,arCOG04376@2157|Archaea,2XV48@28890|Euryarchaeota,23QEX@183939|Methanococci	183939|Methanococci	S	Belongs to the UPF0280 family	-	-	-	ko:K09740	-	-	-	-	ko00000	-	-	-	-
SX1_k127_4958130_3	40492.XP_007309452.1	3.285e-11	76.0	COG1100@1|root,KOG0075@2759|Eukaryota,38F0Z@33154|Opisthokonta,3NWXM@4751|Fungi,3V0T5@5204|Basidiomycota,225G2@155619|Agaricomycetes,3H300@355688|Agaricomycetes incertae sedis	4751|Fungi	U	Signal recognition particle receptor beta subunit	-	-	-	ko:K07955	-	-	-	-	ko00000,ko04031,ko04131	-	-	-	Arf
SX1_k127_4958130_0	666510.ASAC_0924	4.226e-58	214.0	COG0470@1|root,arCOG00469@2157|Archaea,2XPQ0@28889|Crenarchaeota	28889|Crenarchaeota	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcS	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005663,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901576	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,DNA_pol3_delta2,Rep_fac_C,RuvB_N
SX1_k127_4958130_2	224325.AF_2060	2.866e-36	151.0	COG0470@1|root,arCOG00469@2157|Archaea,2XTC8@28890|Euryarchaeota,24622@183980|Archaeoglobi	183980|Archaeoglobi	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcS	-	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,Intein_splicing,Rep_fac_C,RuvB_N
SX1_k127_4958130_1	573063.Metin_0253	4.117e-56	212.0	COG0470@1|root,arCOG00470@2157|Archaea,2XT81@28890|Euryarchaeota,23Q03@183939|Methanococci	183939|Methanococci	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcL	-	-	ko:K04800	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,Rad17
SX1_k127_4960259_0	592031.GCWU000322_00872	2.111e-15	85.0	COG0530@1|root,COG0530@2|Bacteria,1TRX0@1239|Firmicutes,24ABZ@186801|Clostridia,25V4F@186806|Eubacteriaceae	186801|Clostridia	P	K -dependent Na Ca exchanger family protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
SX1_k127_4960259_1	138119.DSY1985	0.0005037	51.0	2E4P6@1|root,32ZHX@2|Bacteria,1VCAE@1239|Firmicutes,24PE5@186801|Clostridia,262IB@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM C_GCAxxG_C_C family	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
SX1_k127_4964563_2	1304885.AUEY01000094_gene3535	1.488e-39	156.0	29CZA@1|root,2ZZXB@2|Bacteria,1RFNE@1224|Proteobacteria,42TRV@68525|delta/epsilon subdivisions,2WR3X@28221|Deltaproteobacteria,2MKTT@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_4964563_1	1117379.BABA_03324	6.604e-41	155.0	COG2050@1|root,COG2050@2|Bacteria,1VNH2@1239|Firmicutes,4I64C@91061|Bacilli,1ZGNM@1386|Bacillus	91061|Bacilli	Q	Domain of unknown function (DUF4442)	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
SX1_k127_4964563_0	1304885.AUEY01000047_gene84	9.436e-49	181.0	29CZA@1|root,2ZZXB@2|Bacteria,1RFNE@1224|Proteobacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_4973134_0	391587.KAOT1_22531	1.099e-22	111.0	COG1960@1|root,COG1960@2|Bacteria,4NFD4@976|Bacteroidetes,1HWQD@117743|Flavobacteriia	976|Bacteroidetes	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SX1_k127_4974742_3	394503.Ccel_0535	1.652e-32	133.0	COG0663@1|root,COG0663@2|Bacteria,1V6CZ@1239|Firmicutes,24JAK@186801|Clostridia,36IWM@31979|Clostridiaceae	186801|Clostridia	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
SX1_k127_4974742_2	1332071.L581_4508	8.17e-49	184.0	COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,1RQJT@1236|Gammaproteobacteria,404KF@613|Serratia	1236|Gammaproteobacteria	IQ	NAD dependent epimerase/dehydratase family	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
SX1_k127_4974742_0	1265505.ATUG01000001_gene3174	7.464e-96	332.0	COG1042@1|root,COG1042@2|Bacteria,1R8Q6@1224|Proteobacteria,42NR2@68525|delta/epsilon subdivisions,2WM2A@28221|Deltaproteobacteria,2MN2C@213118|Desulfobacterales	28221|Deltaproteobacteria	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2,Succ_CoA_lig
SX1_k127_4974742_4	383372.Rcas_2235	3.54e-21	97.0	2EKJA@1|root,313YA@2|Bacteria,2GAJ9@200795|Chloroflexi,376HE@32061|Chloroflexia	32061|Chloroflexia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_4974742_1	756272.Plabr_1640	7.161e-60	224.0	COG1626@1|root,COG1626@2|Bacteria	2|Bacteria	G	alpha,alpha-trehalase activity	treA	GO:0003674,GO:0003824,GO:0004553,GO:0004555,GO:0005575,GO:0005623,GO:0005975,GO:0005984,GO:0005991,GO:0005993,GO:0006950,GO:0006970,GO:0006972,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009628,GO:0009987,GO:0015926,GO:0015927,GO:0016052,GO:0016787,GO:0016798,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0042597,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044464,GO:0046352,GO:0050896,GO:0051716,GO:0071214,GO:0071470,GO:0071474,GO:0071704,GO:0104004,GO:1901575	3.2.1.28	ko:K01194,ko:K03931	ko00500,ko01100,map00500,map01100	-	R00010	RC00049	ko00000,ko00001,ko00537,ko01000	-	GH37,GH63	iAF1260.b1197,iB21_1397.B21_01182,iBWG_1329.BWG_1022,iECBD_1354.ECBD_2425,iECB_1328.ECB_01172,iECDH10B_1368.ECDH10B_1250,iECDH1ME8569_1439.ECDH1ME8569_1136,iECD_1391.ECD_01172,iECUMN_1333.ECUMN_1493,iETEC_1333.ETEC_1301,iEcDH1_1363.EcDH1_2451,iEcHS_1320.EcHS_A1301,iEcolC_1368.EcolC_2429,iJO1366.b1197,iJR904.b1197,iSBO_1134.SBO_3518,iY75_1357.Y75_RS06245	Glyco_hydro_63,Trehalase
SX1_k127_4975711_4	368407.Memar_0621	2.834e-26	112.0	COG1153@1|root,arCOG02674@2157|Archaea,2XXYM@28890|Euryarchaeota,2NB08@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM molydopterin dinucleotide-binding region	fwdD-1	-	1.2.7.12	ko:K00203	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molydop_binding
SX1_k127_4975711_5	1121904.ARBP01000003_gene6328	6.638e-05	55.0	COG3119@1|root,COG3119@2|Bacteria,4NGZQ@976|Bacteroidetes,47UBW@768503|Cytophagia	976|Bacteroidetes	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
SX1_k127_4975711_0	880073.Calab_0813	2.999e-131	448.0	COG1199@1|root,COG1199@2|Bacteria	2|Bacteria	L	ATP-dependent helicase activity	-	-	3.6.4.12	ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2
SX1_k127_4975711_2	1234664.AMRO01000009_gene785	7.201e-64	236.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
SX1_k127_4975711_3	880073.Calab_1105	4.265e-30	138.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	ko:K17713,ko:K20952	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	1.B.33.1	-	-	Beta-prism_lec,PQQ_2,PQQ_3,Peptidase_S8,Pkinase,VCBS
SX1_k127_4975711_1	439235.Dalk_4525	3.96e-117	389.0	COG1748@1|root,COG1748@2|Bacteria,1NIU2@1224|Proteobacteria,42MHS@68525|delta/epsilon subdivisions,2WJQW@28221|Deltaproteobacteria,2MHRC@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Saccharopine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
SX1_k127_4982811_1	1227453.C444_05561	1.929e-05	51.0	arCOG04629@1|root,arCOG04629@2157|Archaea,2XYVJ@28890|Euryarchaeota,23WZG@183963|Halobacteria	183963|Halobacteria	S	Uncharacterised protein family (UPF0175)	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1,UPF0175
SX1_k127_4982811_0	1231057.AMGD01000004_gene2896	2.066e-113	373.0	COG0673@1|root,COG0673@2|Bacteria,1TSUT@1239|Firmicutes,4HDBM@91061|Bacilli	91061|Bacilli	S	oxidoreductase	yteT	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX1_k127_4997736_1	760011.Spico_0376	2.252e-147	479.0	COG2270@1|root,COG2270@2|Bacteria,2J9X6@203691|Spirochaetes	203691|Spirochaetes	S	Vacuole effluxer Atg22 like	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
SX1_k127_4997736_5	1459636.NTE_02945	7.985e-32	138.0	COG0611@1|root,arCOG00638@2157|Archaea,41SIN@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
SX1_k127_4997736_2	391623.TERMP_01874	1.737e-94	325.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,242PQ@183968|Thermococci	183968|Thermococci	L	Involved in regulation of DNA replication	cdc6	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA,AAA_16,Cdc6_C
SX1_k127_4997736_4	264951.V5HTF1	1.749e-50	189.0	COG0846@1|root,KOG1905@2759|Eukaryota,3AW0E@33154|Opisthokonta,3PYAT@4751|Fungi,3RHDV@4890|Ascomycota,20N62@147545|Eurotiomycetes,3SD6C@5042|Eurotiales	4751|Fungi	BK	Sir2 family	-	-	-	-	-	-	-	-	-	-	-	-	SIR2
SX1_k127_4997736_7	639282.DEFDS_2126	9.419e-14	82.0	COG1051@1|root,COG1893@1|root,COG1051@2|Bacteria,COG1893@2|Bacteria,2GF46@200930|Deferribacteres	200930|Deferribacteres	FH	Ketopantoate reductase PanE/ApbA C terminal	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C,NUDIX
SX1_k127_4997736_6	397291.C804_04293	1.901e-29	136.0	COG0531@1|root,COG0531@2|Bacteria,1TQ4K@1239|Firmicutes,25E7A@186801|Clostridia,27NH5@186928|unclassified Lachnospiraceae	186801|Clostridia	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2,Usp
SX1_k127_4997736_3	756499.Desde_2069	9.429e-59	214.0	COG0778@1|root,COG0778@2|Bacteria,1V0NJ@1239|Firmicutes,24FM7@186801|Clostridia,261PI@186807|Peptococcaceae	186801|Clostridia	C	PFAM Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	TM1586_NiRdase
SX1_k127_4997736_0	243231.GSU1634	6.272e-229	728.0	COG0046@1|root,COG1828@1|root,COG0046@2|Bacteria,COG1828@2|Bacteria,1MYN4@1224|Proteobacteria,42M08@68525|delta/epsilon subdivisions,2WITS@28221|Deltaproteobacteria,43TKA@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,PurS
SX1_k127_5003227_1	573413.Spirs_0238	7.017e-25	106.0	COG1143@1|root,COG1143@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7
SX1_k127_5003227_0	1089553.Tph_c04770	1.525e-295	918.0	COG1053@1|root,COG1053@2|Bacteria,1TRE8@1239|Firmicutes,247TH@186801|Clostridia,42FV6@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein	-	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
SX1_k127_5039732_0	65393.PCC7424_2215	3.651e-45	183.0	COG3591@1|root,COG5276@1|root,COG3591@2|Bacteria,COG5276@2|Bacteria,1G8I7@1117|Cyanobacteria	1117|Cyanobacteria	E	Belongs to the peptidase S1B family	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin,Trypsin_2
SX1_k127_5039732_1	189426.PODO_11670	1.032e-36	149.0	2ASZS@1|root,31IFG@2|Bacteria,1V50D@1239|Firmicutes,4HZ96@91061|Bacilli,26R48@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_5039732_2	1123300.AUIN01000019_gene1040	2.759e-06	55.0	COG0716@1|root,COG0716@2|Bacteria,1V45R@1239|Firmicutes,4HQY8@91061|Bacilli	91061|Bacilli	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_4
SX1_k127_5039732_3	867902.Ornrh_0887	0.000307	45.0	2ASD9@1|root,31HSR@2|Bacteria,4NQ71@976|Bacteroidetes,1I2S7@117743|Flavobacteriia	976|Bacteroidetes	S	DNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3276
SX1_k127_5049860_0	857293.CAAU_0758	4.686e-107	358.0	COG2309@1|root,COG2309@2|Bacteria,1TP65@1239|Firmicutes,24AR8@186801|Clostridia,36E9B@31979|Clostridiaceae	186801|Clostridia	E	aminopeptidase	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
SX1_k127_5049860_1	1347392.CCEZ01000019_gene993	2.558e-55	205.0	COG1785@1|root,COG1785@2|Bacteria,1TQCI@1239|Firmicutes,248GG@186801|Clostridia,36GQQ@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the alkaline phosphatase family	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase
SX1_k127_505660_0	1047013.AQSP01000134_gene1338	3.716e-139	457.0	COG5598@1|root,COG5598@2|Bacteria,2NQTC@2323|unclassified Bacteria	2|Bacteria	H	Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
SX1_k127_505660_1	1521187.JPIM01000112_gene2332	1.51e-14	81.0	COG0286@1|root,COG2852@1|root,COG0286@2|Bacteria,COG2852@2|Bacteria,2G859@200795|Chloroflexi,377GB@32061|Chloroflexia	32061|Chloroflexia	L	N-6 DNA Methylase	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
SX1_k127_50584_1	439235.Dalk_0619	5.734e-43	168.0	COG2159@1|root,COG2159@2|Bacteria,1MXP5@1224|Proteobacteria,42PFQ@68525|delta/epsilon subdivisions,2WJ3V@28221|Deltaproteobacteria,2MHUZ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
SX1_k127_50584_4	880072.Desac_0892	3.118e-05	55.0	arCOG09742@1|root,2ZBGR@2|Bacteria,1R9H3@1224|Proteobacteria,42XHN@68525|delta/epsilon subdivisions,2WT8H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_50584_2	765910.MARPU_00380	6.176e-15	85.0	COG3907@1|root,COG3907@2|Bacteria,1QV68@1224|Proteobacteria,1TIBV@1236|Gammaproteobacteria,1WW5N@135613|Chromatiales	135613|Chromatiales	S	PFAM Phosphatidic acid phosphatase type 2 haloperoxidase	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
SX1_k127_50584_0	5888.CAK91022	3.605e-106	365.0	COG3914@1|root,KOG4626@2759|Eukaryota,3ZDCY@5878|Ciliophora	5878|Ciliophora	GOT	TPR Domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
SX1_k127_50584_3	247490.KSU1_C0048	2.216e-06	54.0	COG2211@1|root,COG2211@2|Bacteria,2IY9C@203682|Planctomycetes	203682|Planctomycetes	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX1_k127_5058799_0	880070.Cycma_1061	5.831e-13	69.0	COG1012@1|root,COG1012@2|Bacteria,4NFTW@976|Bacteroidetes,47JZ2@768503|Cytophagia	976|Bacteroidetes	C	TIGRFAM delta-1-pyrroline-5-carboxylate dehydrogenase, group 1	pruA	-	1.2.1.88,1.5.5.2	ko:K00294,ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh
SX1_k127_5098703_0	6087.XP_002170802.2	5.816e-18	90.0	COG1112@1|root,COG5017@1|root,KOG1805@2759|Eukaryota,KOG3349@2759|Eukaryota,38C48@33154|Opisthokonta,3BEJG@33208|Metazoa	33208|Metazoa	L	DNA replication, Okazaki fragment processing	DNA2	GO:0000002,GO:0000014,GO:0000075,GO:0000076,GO:0000228,GO:0000278,GO:0000723,GO:0000729,GO:0000781,GO:0000784,GO:0001325,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005739,GO:0005759,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006264,GO:0006271,GO:0006273,GO:0006275,GO:0006281,GO:0006284,GO:0006302,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007005,GO:0007049,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009295,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010556,GO:0010557,GO:0010604,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0016888,GO:0016890,GO:0016893,GO:0017108,GO:0017111,GO:0019219,GO:0019222,GO:0019439,GO:0019725,GO:0022402,GO:0022607,GO:0022616,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031570,GO:0031974,GO:0031981,GO:0032042,GO:0032200,GO:0032201,GO:0032392,GO:0032508,GO:0033260,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0042592,GO:0042623,GO:0042645,GO:0043137,GO:0043139,GO:0043141,GO:0043142,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043504,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044454,GO:0044464,GO:0044786,GO:0044806,GO:0045740,GO:0045786,GO:0045935,GO:0046483,GO:0046700,GO:0048256,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051173,GO:0051276,GO:0051716,GO:0051726,GO:0060249,GO:0060255,GO:0065007,GO:0065008,GO:0070013,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090656,GO:0090737,GO:0097159,GO:0098687,GO:0140097,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901576,GO:1902990,GO:1903047,GO:2000112	2.10.1.1,2.7.7.75,3.6.4.12	ko:K10742,ko:K15376	ko00790,ko01100,ko03030,ko04727,map00790,map01100,map03030,map04727	-	R09726,R09735	RC00002,RC03462	ko00000,ko00001,ko01000,ko03032	-	-	-	AAA_11,AAA_12,Dna2
SX1_k127_5098703_1	647113.Metok_1474	1.151e-05	55.0	COG0550@1|root,arCOG01305@1|root,arCOG01305@2157|Archaea,arCOG01527@2157|Archaea,2XU6T@28890|Euryarchaeota,23QA8@183939|Methanococci	183939|Methanococci	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Intein_splicing,Topoisom_bac,Toprim,zf-C4_Topoisom
SX1_k127_5104387_1	760011.Spico_1044	2.314e-74	263.0	COG0006@1|root,COG0673@1|root,COG0006@2|Bacteria,COG0673@2|Bacteria,2J6T7@203691|Spirochaetes	203691|Spirochaetes	E	Oxidoreductase family, C-terminal alpha beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX1_k127_5104387_0	402881.Plav_0833	1.413e-123	419.0	COG2730@1|root,COG2730@2|Bacteria,1R5YR@1224|Proteobacteria,2U55F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Cellulase (glycosyl hydrolase family 5)	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase
SX1_k127_5104387_3	1280948.HY36_14450	7.976e-05	50.0	COG3255@1|root,COG3255@2|Bacteria,1N0RD@1224|Proteobacteria,2UBXK@28211|Alphaproteobacteria,43Y7X@69657|Hyphomonadaceae	28211|Alphaproteobacteria	I	SCP-2 sterol transfer family protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
SX1_k127_5104522_2	397948.Cmaq_1106	1.381e-45	183.0	COG2407@1|root,arCOG01772@2157|Archaea	2157|Archaea	G	L-fucose isomerase and related	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_5104522_1	374847.Kcr_1258	5.355e-74	263.0	COG1363@1|root,arCOG01518@2157|Archaea	2157|Archaea	G	peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
SX1_k127_5104522_0	1089547.KB913013_gene1481	1.193e-82	284.0	COG2267@1|root,COG2267@2|Bacteria,4PKB6@976|Bacteroidetes,47JMT@768503|Cytophagia	976|Bacteroidetes	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
SX1_k127_5104522_3	406124.ACPC01000010_gene2270	2.249e-35	137.0	2DNQ8@1|root,32YJ3@2|Bacteria,1VHCH@1239|Firmicutes,4HQ4Q@91061|Bacilli,1ZJ8K@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_5105056_1	1301100.HG529244_gene2325	4.791e-75	265.0	COG3875@1|root,COG3875@2|Bacteria,1TQ1C@1239|Firmicutes,247PH@186801|Clostridia,36DMW@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF2088)	-	-	5.1.2.1	ko:K22373	ko00620,map00620	-	R01450	RC00519	ko00000,ko00001,ko01000	-	-	-	DUF2088
SX1_k127_5105056_0	398512.JQKC01000013_gene1455	4.104e-78	263.0	28H95@1|root,2Z7KY@2|Bacteria,1TQTR@1239|Firmicutes,24BKB@186801|Clostridia,3WJK1@541000|Ruminococcaceae	186801|Clostridia	S	Protein of unknown function (DUF4256)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4256
SX1_k127_5149694_2	1121448.DGI_3015	1.262e-20	104.0	COG2006@1|root,COG2006@2|Bacteria,1N7GG@1224|Proteobacteria,42VMY@68525|delta/epsilon subdivisions,2WRZG@28221|Deltaproteobacteria,2M964@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
SX1_k127_5149694_0	411467.BACCAP_01478	1.567e-79	274.0	COG1233@1|root,COG1233@2|Bacteria,1TS4A@1239|Firmicutes,249K1@186801|Clostridia	186801|Clostridia	Q	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
SX1_k127_5149694_1	411467.BACCAP_01478	1.402e-25	110.0	COG1233@1|root,COG1233@2|Bacteria,1TS4A@1239|Firmicutes,249K1@186801|Clostridia	186801|Clostridia	Q	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
SX1_k127_5162578_4	621372.ACIH01000055_gene1157	1.417e-26	121.0	COG2211@1|root,COG2211@2|Bacteria,1TRA5@1239|Firmicutes,4HJPK@91061|Bacilli,275UP@186822|Paenibacillaceae	91061|Bacilli	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX1_k127_5162578_3	1499967.BAYZ01000057_gene4737	1.388e-57	214.0	COG0673@1|root,COG0673@2|Bacteria,2NRVS@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX1_k127_5162578_0	865861.AZSU01000001_gene503	2.963e-169	548.0	COG0129@1|root,COG0129@2|Bacteria,1TP1R@1239|Firmicutes,247UC@186801|Clostridia,36DS1@31979|Clostridiaceae	186801|Clostridia	EG	Belongs to the IlvD Edd family	-	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
SX1_k127_5162578_1	37919.EP51_18690	2.865e-153	505.0	COG0028@1|root,COG0028@2|Bacteria,2I9V6@201174|Actinobacteria,4G67U@85025|Nocardiaceae	201174|Actinobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
SX1_k127_5162578_5	6669.EFX69127	4.868e-10	71.0	COG1100@1|root,KOG0074@2759|Eukaryota,390S3@33154|Opisthokonta,3BEVQ@33208|Metazoa,3CUMZ@33213|Bilateria,41XJH@6656|Arthropoda	33208|Metazoa	U	Belongs to the small GTPase superfamily. Arf family	ARL3	GO:0000139,GO:0000166,GO:0000278,GO:0000281,GO:0000910,GO:0001655,GO:0001763,GO:0001822,GO:0001882,GO:0001883,GO:0002009,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005794,GO:0005813,GO:0005815,GO:0005819,GO:0005856,GO:0005874,GO:0005876,GO:0005881,GO:0005929,GO:0005930,GO:0006810,GO:0006892,GO:0006928,GO:0006996,GO:0007017,GO:0007018,GO:0007049,GO:0007154,GO:0007165,GO:0007166,GO:0007224,GO:0007264,GO:0007275,GO:0007399,GO:0007424,GO:0008017,GO:0008092,GO:0008150,GO:0009653,GO:0009888,GO:0009987,GO:0010970,GO:0012505,GO:0015630,GO:0015631,GO:0016020,GO:0016043,GO:0016192,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0022008,GO:0022402,GO:0022607,GO:0023052,GO:0030030,GO:0030031,GO:0030154,GO:0030182,GO:0030496,GO:0030705,GO:0031090,GO:0031503,GO:0031984,GO:0032391,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032838,GO:0035146,GO:0035147,GO:0035239,GO:0035295,GO:0035556,GO:0035639,GO:0035869,GO:0036064,GO:0036094,GO:0042073,GO:0042461,GO:0042995,GO:0043005,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0044085,GO:0044422,GO:0044424,GO:0044430,GO:0044431,GO:0044441,GO:0044444,GO:0044446,GO:0044463,GO:0044464,GO:0044782,GO:0046530,GO:0046907,GO:0048193,GO:0048468,GO:0048513,GO:0048666,GO:0048699,GO:0048729,GO:0048731,GO:0048754,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0051301,GO:0051641,GO:0051649,GO:0051716,GO:0060271,GO:0060429,GO:0060446,GO:0060541,GO:0060562,GO:0061138,GO:0061640,GO:0065007,GO:0070925,GO:0071840,GO:0072001,GO:0097014,GO:0097159,GO:0097367,GO:0097458,GO:0097730,GO:0097731,GO:0097733,GO:0098588,GO:0098791,GO:0099080,GO:0099081,GO:0099111,GO:0099512,GO:0099513,GO:0099568,GO:0120025,GO:0120031,GO:0120036,GO:0120038,GO:1901265,GO:1901363,GO:1903047	-	ko:K07944,ko:K11278	-	-	-	-	ko00000,ko03036,ko04031	-	-	-	Arf
SX1_k127_5162578_2	272844.PAB0417	2.712e-59	213.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,242UI@183968|Thermococci	183968|Thermococci	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
SX1_k127_5162578_6	1353529.M899_0121	1.516e-08	66.0	COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,42NWB@68525|delta/epsilon subdivisions,2MSZT@213481|Bdellovibrionales,2WKKE@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	von Willebrand factor, type A	batA	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA
SX1_k127_5162578_7	933801.Ahos_0703	3.223e-05	51.0	COG3609@1|root,arCOG01009@2157|Archaea	2157|Archaea	K	transcriptional regulators containing the CopG Arc MetJ DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
SX1_k127_5168386_3	431943.CKL_2353	2.312e-19	99.0	COG2267@1|root,COG2267@2|Bacteria,1V1N4@1239|Firmicutes,24GC7@186801|Clostridia	186801|Clostridia	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
SX1_k127_5168386_1	673860.AciM339_1147	1.753e-58	209.0	COG1838@1|root,arCOG04406@2157|Archaea,2XXBQ@28890|Euryarchaeota,3F2QU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Fe-S type, tartrate fumarate subfamily, beta	fumB	-	4.2.1.2	ko:K01678	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
SX1_k127_5168386_0	1343739.PAP_05865	1.253e-74	260.0	COG1951@1|root,arCOG04407@2157|Archaea,2XUQI@28890|Euryarchaeota,242SI@183968|Thermococci	183968|Thermococci	C	Fumarate hydratase	-	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
SX1_k127_5168386_2	698737.SLGD_00808	1.903e-54	203.0	COG1131@1|root,COG1131@2|Bacteria,1UHTY@1239|Firmicutes,4ISIK@91061|Bacilli,4H1RZ@90964|Staphylococcaceae	91061|Bacilli	V	ATPases associated with a variety of cellular activities	natA	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX1_k127_5178064_4	476272.RUMHYD_01277	7.879e-13	72.0	COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,3XZDA@572511|Blautia	186801|Clostridia	G	Psort location Cytoplasmic, score 8.87	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
SX1_k127_5178064_1	1033740.CAEW01000028_gene2638	6.379e-28	129.0	COG1233@1|root,COG1233@2|Bacteria,1TS4A@1239|Firmicutes,4HB9J@91061|Bacilli,26D9H@186818|Planococcaceae	91061|Bacilli	Q	Flavin containing amine oxidoreductase	-	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
SX1_k127_5178064_3	877415.JNJQ01000011_gene674	5.342e-13	78.0	COG2120@1|root,COG2120@2|Bacteria,1TUFQ@1239|Firmicutes,3VS7E@526524|Erysipelotrichia	526524|Erysipelotrichia	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
SX1_k127_5178064_0	401053.AciPR4_2350	1.464e-50	195.0	COG0477@1|root,COG2814@2|Bacteria,3Y4T2@57723|Acidobacteria,2JKF4@204432|Acidobacteriia	204432|Acidobacteriia	EGP	MFS_1 like family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX1_k127_5178064_5	1033810.HLPCO_002908	6.189e-09	66.0	COG3420@1|root,COG4932@1|root,COG5604@1|root,COG3420@2|Bacteria,COG4932@2|Bacteria,COG5604@2|Bacteria	2|Bacteria	DZ	domain, Protein	bhp	-	3.2.1.18	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	-	R04018	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33	-	Beta_helix,DUF5011,Flg_new,Gram_pos_anchor,He_PIG,YSIRK_signal
SX1_k127_5194542_1	1382306.JNIM01000001_gene2968	7.538e-52	192.0	COG1070@1|root,COG1070@2|Bacteria,2G7ND@200795|Chloroflexi	200795|Chloroflexi	G	FGGY family of carbohydrate kinases, N-terminal domain	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
SX1_k127_5194542_2	1365176.N186_02390	3.109e-20	94.0	COG1758@1|root,arCOG01268@2157|Archaea,2XR3X@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoK	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03014,ko:K03055	ko00230,ko00240,ko01100,ko03020,ko04623,ko05016,ko05169,map00230,map00240,map01100,map03020,map04623,map05016,map05169	M00180,M00181,M00182,M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
SX1_k127_5194542_0	1343739.PAP_06530	7.507e-151	504.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,243CX@183968|Thermococci	183968|Thermococci	L	ERCC4 domain	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,Helicase_C
SX1_k127_5195634_0	1334046.AYTB01000008_gene2806	1.876e-79	284.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,4HA2G@91061|Bacilli,26DJ2@186818|Planococcaceae	91061|Bacilli	IQ	AMP-binding enzyme C-terminal domain	lcfA	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
SX1_k127_5195634_1	272563.CD630_18220	2.945e-42	159.0	COG1225@1|root,COG1225@2|Bacteria,1V3N5@1239|Firmicutes,24HP8@186801|Clostridia,25RHV@186804|Peptostreptococcaceae	186801|Clostridia	O	Antioxidant, AhpC TSA family	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
SX1_k127_5213637_1	525904.Tter_2199	6.936e-71	248.0	COG2227@1|root,COG2227@2|Bacteria,2NRF7@2323|unclassified Bacteria	2|Bacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_12,Methyltransf_25
SX1_k127_5213637_2	592015.HMPREF1705_01564	2.555e-33	138.0	COG1515@1|root,COG1515@2|Bacteria,3TB0A@508458|Synergistetes	508458|Synergistetes	L	DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA	nfi	-	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
SX1_k127_5213637_0	1540257.JQMW01000011_gene2110	9.511e-157	509.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,36E4P@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SX1_k127_5214353_0	177437.HRM2_40920	1.841e-79	274.0	COG1032@1|root,COG1032@2|Bacteria,1P9J0@1224|Proteobacteria,42MWG@68525|delta/epsilon subdivisions,2WIV5@28221|Deltaproteobacteria,2MI1A@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SX1_k127_5214353_2	5865.XP_001610266.1	1.56e-07	64.0	COG1310@1|root,KOG1555@2759|Eukaryota,3Y9VG@5794|Apicomplexa,3KA8Q@422676|Aconoidasida,3Z52G@5863|Piroplasmida	422676|Aconoidasida	O	Proteasome regulatory subunit	-	-	-	ko:K03030	ko03050,ko05169,map03050,map05169	M00341	-	-	ko00000,ko00001,ko00002,ko01002,ko03051,ko04121	-	-	-	JAB,MitMem_reg
SX1_k127_5214353_1	1288484.APCS01000091_gene1505	4.513e-15	81.0	COG2211@1|root,COG2211@2|Bacteria,1WIWY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX1_k127_5224039_1	399549.Msed_0033	1.344e-86	293.0	COG0085@1|root,arCOG01762@2157|Archaea,2XPRW@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
SX1_k127_5224039_5	579137.Metvu_1537	5.805e-16	81.0	COG2012@1|root,arCOG04258@2157|Archaea,2Y0EY@28890|Euryarchaeota,23RAF@183939|Methanococci	183939|Methanococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoH	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03053	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb5_C
SX1_k127_5224039_3	720554.Clocl_3863	3.581e-32	134.0	COG2813@1|root,COG2813@2|Bacteria,1V1BG@1239|Firmicutes,24KC2@186801|Clostridia,3WJFC@541000|Ruminococcaceae	186801|Clostridia	J	Lysine methyltransferase	-	-	2.1.1.172	ko:K00564	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	MTS
SX1_k127_5224039_0	877455.Metbo_0804	1.394e-104	349.0	COG0130@1|root,arCOG00987@2157|Archaea,2XTUE@28890|Euryarchaeota,23NQV@183925|Methanobacteria	183925|Methanobacteria	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	-	-	ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03032	-	-	-	DKCLD,PUA,TruB_C_2,TruB_N
SX1_k127_5224039_4	5762.XP_002678585.1	1.474e-29	125.0	KOG4423@1|root,KOG4423@2759|Eukaryota	2759|Eukaryota	E	BLOC-2 complex binding	glo-1	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0005802,GO:0006996,GO:0007033,GO:0007040,GO:0008150,GO:0009987,GO:0010876,GO:0012505,GO:0016020,GO:0016043,GO:0016050,GO:0019915,GO:0031090,GO:0031410,GO:0031982,GO:0031984,GO:0032438,GO:0033036,GO:0033059,GO:0042470,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043473,GO:0044422,GO:0044424,GO:0044431,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0044840,GO:0044841,GO:0048753,GO:0048770,GO:0051179,GO:0051235,GO:0065007,GO:0065008,GO:0071840,GO:0080171,GO:0097708,GO:0098791	-	ko:K07918,ko:K07923	-	-	-	-	ko00000,ko04031,ko04131	-	-	-	Ras
SX1_k127_5224039_2	1454007.JAUG01000047_gene512	4.293e-80	279.0	COG0673@1|root,COG0673@2|Bacteria,4NJ92@976|Bacteroidetes,1ISF7@117747|Sphingobacteriia	976|Bacteroidetes	S	Oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX1_k127_5241452_2	247490.KSU1_C1344	2.509e-21	107.0	COG0827@1|root,COG1002@1|root,COG2810@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,COG2810@2|Bacteria,2J13P@203682|Planctomycetes	203682|Planctomycetes	L	Pfam:Methyltransf_26	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase,TaqI_C
SX1_k127_5241452_1	1041930.Mtc_2391	1.533e-26	117.0	COG1522@1|root,arCOG01580@2157|Archaea,2XXQR@28890|Euryarchaeota	28890|Euryarchaeota	K	transcriptional regulator, AsnC family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
SX1_k127_5241452_0	1121930.AQXG01000001_gene1276	7.135e-40	153.0	COG0334@1|root,COG0334@2|Bacteria,4NEBH@976|Bacteroidetes,1IWSF@117747|Sphingobacteriia	976|Bacteroidetes	E	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	gdhA	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
SX1_k127_5241798_1	1121324.CLIT_13c00180	1.456e-17	97.0	COG0577@1|root,COG0577@2|Bacteria,1TPHU@1239|Firmicutes,248RV@186801|Clostridia	186801|Clostridia	V	Efflux ABC transporter, permease protein	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX1_k127_5241798_0	192952.MM_3095	1.503e-60	218.0	COG1136@1|root,arCOG00922@2157|Archaea,2XUH3@28890|Euryarchaeota,2NAKT@224756|Methanomicrobia	224756|Methanomicrobia	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX1_k127_5241798_2	1121441.AUCX01000010_gene117	6.265e-06	54.0	2DVKF@1|root,33W9C@2|Bacteria,1NWBJ@1224|Proteobacteria,4308J@68525|delta/epsilon subdivisions,2WVCC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
SX1_k127_5241846_0	1191523.MROS_0971	7.9e-188	616.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
SX1_k127_5253581_3	273063.STK_07597	1.383e-06	55.0	COG1958@1|root,arCOG00998@2157|Archaea,2XR0V@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM Like-Sm ribonucleoprotein, core	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
SX1_k127_5253581_1	419665.Maeo_0291	1.34e-13	72.0	COG2126@1|root,arCOG04126@2157|Archaea,2XZUV@28890|Euryarchaeota,23R74@183939|Methanococci	183939|Methanococci	J	binds to the 23S rRNA	rpl37e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02922	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37e
SX1_k127_5253581_2	1158338.JNLJ01000001_gene227	2.837e-08	57.0	COG0425@1|root,COG0425@2|Bacteria,2G5AY@200783|Aquificae	200783|Aquificae	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	TusA
SX1_k127_5253581_0	1121422.AUMW01000036_gene2696	1.356e-91	325.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,26166@186807|Peptococcaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,Pyr_redox_2
SX1_k127_5267842_0	706587.Desti_3575	2.622e-110	374.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,42R6X@68525|delta/epsilon subdivisions,2WMY9@28221|Deltaproteobacteria,2MSBC@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
SX1_k127_528862_0	555079.Toce_1342	6.141e-198	640.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,42EJU@68295|Thermoanaerobacterales	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
SX1_k127_528862_1	1267534.KB906755_gene4274	0.0006667	44.0	COG1983@1|root,COG1983@2|Bacteria,3Y5HA@57723|Acidobacteria,2JJXD@204432|Acidobacteriia	204432|Acidobacteriia	KT	PspC domain	-	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	PspC,zinc_ribbon_2
SX1_k127_5331_2	1047013.AQSP01000144_gene917	5.648e-20	90.0	COG2044@1|root,COG2044@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07092	-	-	-	-	ko00000	-	-	-	DrsE,DrsE_2
SX1_k127_5331_1	1047013.AQSP01000144_gene918	2.389e-20	92.0	COG0425@1|root,COG0425@2|Bacteria	2|Bacteria	O	sulfur carrier activity	tusA	GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0019725,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042592,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048878,GO:0051186,GO:0051188,GO:0051189,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0090407,GO:0097163,GO:0140104,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.14,2.8.1.7	ko:K00549,ko:K04085,ko:K04487,ko:K08363	ko00270,ko00450,ko00730,ko01100,ko01110,ko01230,ko04122,map00270,map00450,map00730,map01100,map01110,map01230,map04122	M00017	R04405,R07460,R09365,R11528,R11529	RC00035,RC00113,RC01241,RC01789,RC02313	ko00000,ko00001,ko00002,ko01000,ko02000,ko02048,ko03016,ko03029	1.A.72.1	-	-	DUF2249,Rhodanese,TusA
SX1_k127_5331_3	871963.Desdi_3204	3.541e-13	81.0	2E271@1|root,32XDC@2|Bacteria,1V9QC@1239|Firmicutes,24KUU@186801|Clostridia	186801|Clostridia	S	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
SX1_k127_5331_0	304371.MCP_1261	1.064e-37	149.0	COG3382@1|root,arCOG04250@2157|Archaea,2Y2KD@28890|Euryarchaeota,2NAIE@224756|Methanomicrobia	224756|Methanomicrobia	S	B3/4 domain	-	-	-	-	-	-	-	-	-	-	-	-	B3_4
SX1_k127_5333592_0	926560.KE387027_gene493	5.213e-17	91.0	2EVIQ@1|root,33NYW@2|Bacteria	2|Bacteria	S	Ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase
SX1_k127_5335483_3	1230342.CTM_23207	2.066e-15	85.0	COG0286@1|root,COG0286@2|Bacteria,1UMSN@1239|Firmicutes,24856@186801|Clostridia,36F0V@31979|Clostridiaceae	186801|Clostridia	V	TaqI-like C-terminal specificity domain	-	-	2.1.1.72	ko:K07317	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Eco57I,N6_Mtase,TaqI_C
SX1_k127_5335483_2	1502851.FG93_00820	2.077e-23	107.0	COG2020@1|root,COG2020@2|Bacteria,1RECR@1224|Proteobacteria,2U6MH@28211|Alphaproteobacteria,3JYJP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
SX1_k127_5335483_1	1173029.JH980292_gene3173	6.364e-31	128.0	COG1100@1|root,COG1100@2|Bacteria,1G5QQ@1117|Cyanobacteria,1HB5W@1150|Oscillatoriales	1117|Cyanobacteria	S	COG1100 GTPase SAR1 and related small G	-	-	-	-	-	-	-	-	-	-	-	-	Ras,Roc
SX1_k127_5335483_5	387631.Asulf_01011	0.0009779	51.0	COG0467@1|root,arCOG01175@2157|Archaea	2157|Archaea	T	COG0467 RecA-superfamily ATPases implicated in signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
SX1_k127_5335483_4	1423321.AS29_00455	5.027e-09	64.0	COG1321@1|root,COG1321@2|Bacteria,1V3IS@1239|Firmicutes,4HH06@91061|Bacilli,1ZFKR@1386|Bacillus	91061|Bacilli	K	Involved in manganese homeostasis. Might activate the transcription of the mntABCD operon	mntR	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
SX1_k127_5335483_0	1295642.H839_17048	6.055e-53	198.0	COG2516@1|root,COG2516@2|Bacteria,1UI8Q@1239|Firmicutes,4HV1D@91061|Bacilli	91061|Bacilli	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SX1_k127_5338685_2	78898.MVEG_07315T0	1.165e-71	247.0	COG1874@1|root,KOG0496@2759|Eukaryota,38D50@33154|Opisthokonta,3NZZH@4751|Fungi,1GS7S@112252|Fungi incertae sedis	4751|Fungi	G	Glycosyl hydrolases family 35	lacA	GO:0003674,GO:0003824,GO:0004553,GO:0004565,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005975,GO:0008150,GO:0008152,GO:0015925,GO:0016787,GO:0016798,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	BetaGal_dom2,BetaGal_dom3,BetaGal_dom4_5,Glyco_hydro_35
SX1_k127_5338685_0	1006006.Mcup_1923	6.204e-124	419.0	COG1793@1|root,arCOG01347@2157|Archaea,2XPV8@28889|Crenarchaeota	28889|Crenarchaeota	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
SX1_k127_5338685_1	1151117.AJLF01000001_gene787	7.626e-118	396.0	COG0213@1|root,arCOG02013@2157|Archaea,2XT19@28890|Euryarchaeota,243SD@183968|Thermococci	183968|Thermococci	F	Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO	deoA	GO:0000166,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006195,GO:0006196,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009125,GO:0009126,GO:0009128,GO:0009150,GO:0009154,GO:0009158,GO:0009161,GO:0009166,GO:0009167,GO:0009169,GO:0009259,GO:0009261,GO:0009987,GO:0016208,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0017076,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0042301,GO:0042737,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0097159,GO:0097367,GO:1901135,GO:1901136,GO:1901265,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576	2.4.2.57	ko:K18931	-	-	R10836,R10837,R10838	RC00063	ko00000,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
SX1_k127_5338685_3	935948.KE386494_gene943	6.699e-54	195.0	COG1082@1|root,COG1830@1|root,COG1082@2|Bacteria,COG1830@2|Bacteria,1TRGF@1239|Firmicutes,248GM@186801|Clostridia,42FYQ@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Xylose isomerase domain-containing protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SX1_k127_5349818_2	1385519.N801_08140	0.0004295	54.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria,4FFAH@85021|Intrasporangiaceae	201174|Actinobacteria	Q	ABC transporter	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX1_k127_5349818_0	771875.Ferpe_0236	1.65e-37	146.0	COG1136@1|root,COG1136@2|Bacteria,2GCNW@200918|Thermotogae	200918|Thermotogae	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX1_k127_5349818_1	469617.FUAG_01464	1.387e-19	93.0	COG1136@1|root,COG1136@2|Bacteria,3783V@32066|Fusobacteria	32066|Fusobacteria	V	ABC transporter	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX1_k127_5354485_0	1047013.AQSP01000138_gene1035	9.258e-99	331.0	COG1032@1|root,COG1032@2|Bacteria,2NQU0@2323|unclassified Bacteria	2|Bacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
SX1_k127_5355184_3	330779.Saci_0416	0.0006591	45.0	COG0517@1|root,arCOG00606@2157|Archaea,2XQQK@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SX1_k127_5355184_1	545695.TREAZ_0476	4.201e-31	130.0	COG1145@1|root,COG1145@2|Bacteria,2J684@203691|Spirochaetes	203691|Spirochaetes	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6
SX1_k127_5355184_2	224325.AF_1743	1.239e-30	127.0	COG1522@1|root,arCOG01585@2157|Archaea,2Y7PY@28890|Euryarchaeota	28890|Euryarchaeota	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
SX1_k127_5355184_0	690850.Desaf_3320	9.751e-47	171.0	COG2033@1|root,COG2033@2|Bacteria,1QNA5@1224|Proteobacteria,435XP@68525|delta/epsilon subdivisions,2X0EC@28221|Deltaproteobacteria,2MC18@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Desulfoferrodoxin	-	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrodox
SX1_k127_5368849_2	1540257.JQMW01000013_gene1139	5.1e-05	49.0	2EAFI@1|root,334IX@2|Bacteria,1VIZH@1239|Firmicutes,24RF5@186801|Clostridia,36MYQ@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_5368849_0	398512.JQKC01000027_gene3915	2.257e-74	264.0	COG1680@1|root,COG1680@2|Bacteria,1TR9E@1239|Firmicutes,2480P@186801|Clostridia,3WRFA@541000|Ruminococcaceae	186801|Clostridia	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SX1_k127_5368849_1	1484460.JSWG01000009_gene429	5.425e-47	173.0	COG2818@1|root,COG2818@2|Bacteria,4NGRC@976|Bacteroidetes,1HYH3@117743|Flavobacteriia	976|Bacteroidetes	L	DNA-3-methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
SX1_k127_5370490_3	227086.JGI_V11_46835	3.541e-106	352.0	COG0448@1|root,KOG1504@2759|Eukaryota	2759|Eukaryota	G	ornithine carbamoyltransferase activity	-	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
SX1_k127_5370490_2	926569.ANT_16670	4.37e-141	457.0	COG0665@1|root,COG0665@2|Bacteria,2G6HT@200795|Chloroflexi	200795|Chloroflexi	E	FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
SX1_k127_5370490_0	1047013.AQSP01000126_gene2731	1.94e-244	773.0	COG0446@1|root,COG1142@1|root,COG1251@1|root,COG2080@1|root,COG0446@2|Bacteria,COG1142@2|Bacteria,COG1251@2|Bacteria,COG2080@2|Bacteria,2NP2E@2323|unclassified Bacteria	2|Bacteria	C	FAD dependent oxidoreductase	-	-	1.12.5.1,1.2.5.3,1.3.99.16,1.7.1.15	ko:K00205,ko:K00362,ko:K02573,ko:K03518,ko:K05927,ko:K07302	ko00680,ko00910,ko01100,ko01120,ko01200,map00680,map00910,map01100,map01120,map01200	M00530,M00567	R00787,R03015,R08060,R11168,R11743	RC00176,RC00197,RC00323,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Fer2_2,Fer2_4,Fer2_BFD,Fer4,Fer4_20,Fer4_7,GXGXG,NiFe_hyd_SSU_C,Oxidored_q6,Pyr_redox_2
SX1_k127_5370490_1	1449126.JQKL01000023_gene202	1.514e-239	756.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,26A1J@186813|unclassified Clostridiales	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
SX1_k127_5380394_6	445971.ANASTE_02150	3.309e-35	141.0	COG1032@1|root,COG1032@2|Bacteria,1TQF0@1239|Firmicutes,24A0T@186801|Clostridia,25URD@186806|Eubacteriaceae	186801|Clostridia	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SX1_k127_5380394_3	342949.PNA2_1861	3.036e-145	480.0	COG1245@1|root,arCOG00187@2157|Archaea,2XSZE@28890|Euryarchaeota,242JH@183968|Thermococci	183968|Thermococci	E	Possible Fer4-like domain in RNase L inhibitor, RLI	-	-	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,RLI
SX1_k127_5380394_5	485915.Dret_1090	6.364e-40	159.0	COG0697@1|root,COG0697@2|Bacteria,1NTS4@1224|Proteobacteria,42ZA1@68525|delta/epsilon subdivisions,2WUDJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SX1_k127_5380394_0	415426.Hbut_1274	2.892e-195	646.0	COG0417@1|root,arCOG15272@2157|Archaea,2XPPT@28889|Crenarchaeota	28889|Crenarchaeota	L	SMART DNA-directed DNA polymerase B	dpo1	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1
SX1_k127_5380394_1	96561.Dole_2160	9.243e-158	508.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42PRI@68525|delta/epsilon subdivisions,2X5GA@28221|Deltaproteobacteria,2MHVA@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
SX1_k127_5380394_7	1033734.CAET01000021_gene1306	3.073e-20	102.0	COG0491@1|root,COG0491@2|Bacteria,1U9UR@1239|Firmicutes,4HCI8@91061|Bacilli,1ZAQ9@1386|Bacillus	91061|Bacilli	S	Metallo-beta-lactamase superfamily	fprA1	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SX1_k127_5380394_4	679926.Mpet_2037	9.547e-57	210.0	COG1254@1|root,arCOG00643@2157|Archaea,2XVIJ@28890|Euryarchaeota	28890|Euryarchaeota	E	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
SX1_k127_5380394_2	579137.Metvu_0815	3.842e-147	482.0	COG3276@1|root,arCOG01563@2157|Archaea,2XUKU@28890|Euryarchaeota,23QPD@183939|Methanococci	183939|Methanococci	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2g	-	-	ko:K03242	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,eIF2_C
SX1_k127_5380394_8	400682.PAC_15723220	1.126e-16	87.0	KOG0420@1|root,KOG0420@2759|Eukaryota,38TD7@33154|Opisthokonta,3BD5A@33208|Metazoa	33208|Metazoa	O	NEDD8 conjugating enzyme activity	UBE2F	GO:0003674,GO:0003824,GO:0004842,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009966,GO:0009968,GO:0009987,GO:0010646,GO:0010648,GO:0016567,GO:0016740,GO:0019538,GO:0019787,GO:0019788,GO:0019899,GO:0023051,GO:0023057,GO:0031625,GO:0032446,GO:0036211,GO:0043170,GO:0043412,GO:0043516,GO:0043518,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044389,GO:0044424,GO:0044444,GO:0044464,GO:0045116,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0061630,GO:0061650,GO:0061654,GO:0061659,GO:0065007,GO:0070647,GO:0071704,GO:0080134,GO:0080135,GO:0140096,GO:1901564,GO:1901796,GO:1901797,GO:1902531,GO:1902532,GO:2001020,GO:2001021	2.3.2.23	ko:K10687	ko04120,map04120	-	-	-	ko00000,ko00001,ko01000,ko04121	-	-	-	UQ_con
SX1_k127_5392360_2	439481.Aboo_1334	2.641e-14	81.0	arCOG02498@1|root,arCOG02499@1|root,arCOG02545@1|root,arCOG02498@2157|Archaea,arCOG02499@2157|Archaea,arCOG02545@2157|Archaea,2Y6YI@28890|Euryarchaeota,3F2WY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	NosD
SX1_k127_5392360_0	177437.HRM2_44930	2.645e-124	406.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,42N9Z@68525|delta/epsilon subdivisions,2WIKQ@28221|Deltaproteobacteria,2MHU6@213118|Desulfobacterales	28221|Deltaproteobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
SX1_k127_5392360_1	224719.Abm4_1650	1.087e-22	113.0	COG1051@1|root,arCOG01075@2157|Archaea,2XZGP@28890|Euryarchaeota,23PPE@183925|Methanobacteria	183925|Methanobacteria	L	NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
SX1_k127_5392360_3	634498.mru_0723	0.0006434	53.0	COG1305@1|root,arCOG02488@1|root,arCOG02526@1|root,arCOG02486@2157|Archaea,arCOG02488@2157|Archaea,arCOG02526@2157|Archaea	2157|Archaea	O	Parallel beta-helix	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_5,Big_5,CHB_HEX_C_1,CarboxypepD_reg,NosD,PKD
SX1_k127_5395789_2	771875.Ferpe_1427	3.84e-12	72.0	COG0477@1|root,COG2814@2|Bacteria,2GCFM@200918|Thermotogae	200918|Thermotogae	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
SX1_k127_5395789_1	415426.Hbut_0362	1.615e-12	76.0	COG2517@1|root,arCOG04359@2157|Archaea,2XR9E@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM t-RNA-binding domain protein	-	-	-	ko:K07135	-	-	-	-	ko00000	-	-	-	tRNA_bind
SX1_k127_5395789_0	877455.Metbo_2230	7.34e-138	446.0	COG0172@1|root,arCOG00403@2157|Archaea,2XTGA@28890|Euryarchaeota,23NQ1@183925|Methanobacteria	183925|Methanobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
SX1_k127_5399010_4	579137.Metvu_0982	3.221e-30	124.0	COG2090@1|root,arCOG04171@2157|Archaea,2XXWX@28890|Euryarchaeota,23R2C@183939|Methanococci	183939|Methanococci	S	Domain of unknown function (DUF371)	-	-	-	ko:K09738	-	-	-	-	ko00000	-	-	-	DUF371
SX1_k127_5399010_3	498761.HM1_1725	2.939e-40	158.0	COG0235@1|root,COG0235@2|Bacteria,1TPDV@1239|Firmicutes,248KI@186801|Clostridia	186801|Clostridia	G	L-ribulose-5-phosphate 4-epimerase	fucA	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
SX1_k127_5399010_0	342949.PNA2_0762	1.699e-154	508.0	COG0449@1|root,arCOG00057@2157|Archaea,2XTC0@28890|Euryarchaeota,243IS@183968|Thermococci	183968|Thermococci	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
SX1_k127_5399010_1	269797.Mbar_A3546	6.955e-109	367.0	COG1900@1|root,arCOG00621@2157|Archaea,2XTFR@28890|Euryarchaeota,2N98V@224756|Methanomicrobia	224756|Methanomicrobia	S	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,HcyBio
SX1_k127_5399010_2	931626.Awo_c17310	1.105e-58	222.0	COG0160@1|root,COG0160@2|Bacteria,1VS6F@1239|Firmicutes,24YI0@186801|Clostridia,25W3P@186806|Eubacteriaceae	186801|Clostridia	H	Aminotransferase class-III	gabT	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iHN637.CLJU_RS10045	Aminotran_3
SX1_k127_5403275_0	1209989.TepiRe1_2165	1.767e-75	269.0	COG1748@1|root,COG1748@2|Bacteria,1TQTN@1239|Firmicutes,24AHW@186801|Clostridia	186801|Clostridia	E	Saccharopine dehydrogenase	LYS1	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
SX1_k127_541351_1	760142.Hipma_0943	2.033e-91	308.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,42M04@68525|delta/epsilon subdivisions,2WJJD@28221|Deltaproteobacteria,2M6AE@213113|Desulfurellales	28221|Deltaproteobacteria	J	DALR_2	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
SX1_k127_541351_0	983917.RGE_11180	6.511e-195	618.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2VHK9@28216|Betaproteobacteria,1KJX3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Aminotransferase	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SX1_k127_541351_2	797303.Natpe_2818	1.041e-14	85.0	COG2810@1|root,arCOG02636@1|root,arCOG04814@1|root,arCOG08946@1|root,arCOG02636@2157|Archaea,arCOG04814@2157|Archaea,arCOG05724@2157|Archaea,arCOG08946@2157|Archaea,2XUQ7@28890|Euryarchaeota,23SFJ@183963|Halobacteria	183963|Halobacteria	V	COG1002 Type II restriction enzyme, methylase subunits	-	-	-	-	-	-	-	-	-	-	-	-	Eco57I,N6_Mtase,TaqI_C
SX1_k127_5417014_0	33035.JPJF01000019_gene4244	5.21e-23	104.0	COG0655@1|root,COG0655@2|Bacteria,1TSDE@1239|Firmicutes,24CNT@186801|Clostridia,3XZ9D@572511|Blautia	186801|Clostridia	S	COG COG0655 Multimeric flavodoxin WrbA	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
SX1_k127_5417014_1	743719.PaelaDRAFT_4727	8.726e-22	106.0	COG0454@1|root,COG3173@1|root,COG0456@2|Bacteria,COG3173@2|Bacteria,1VIJ4@1239|Firmicutes,4HQI2@91061|Bacilli,274RM@186822|Paenibacillaceae	91061|Bacilli	K	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
SX1_k127_5417014_2	585394.RHOM_12995	1.006e-18	93.0	COG2189@1|root,COG2189@2|Bacteria,1TR8A@1239|Firmicutes,249A1@186801|Clostridia	186801|Clostridia	L	PFAM DNA methylase N-4 N-6 domain protein	-	-	2.1.1.72	ko:K00571,ko:K07316	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
SX1_k127_5434806_9	1030157.AFMP01000042_gene1302	1.002e-06	60.0	COG0477@1|root,COG2814@2|Bacteria,1NAK9@1224|Proteobacteria,2UHZU@28211|Alphaproteobacteria,2K2IR@204457|Sphingomonadales	204457|Sphingomonadales	EGP	Sugar (and other) transporter	-	-	-	ko:K08369	-	-	-	-	ko00000,ko02000	2.A.1	-	-	MFS_1
SX1_k127_5434806_1	416591.Tlet_0046	5.672e-60	224.0	COG2211@1|root,COG2211@2|Bacteria,2GDVW@200918|Thermotogae	200918|Thermotogae	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX1_k127_5434806_7	1538644.KO02_15880	9.492e-15	88.0	COG0383@1|root,COG0383@2|Bacteria,4NIM9@976|Bacteroidetes,1IR3M@117747|Sphingobacteriia	976|Bacteroidetes	G	glycoside hydrolase family 38	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
SX1_k127_5434806_6	411902.CLOBOL_03558	5.039e-19	95.0	COG0684@1|root,COG0684@2|Bacteria,1V0GQ@1239|Firmicutes,24DQQ@186801|Clostridia,21Z8M@1506553|Lachnoclostridium	186801|Clostridia	H	Aldolase/RraA	-	-	4.1.3.17	ko:K10218	ko00362,ko00660,ko01120,map00362,map00660,map01120	-	R00008,R00350	RC00067,RC00502,RC01205	ko00000,ko00001,ko01000	-	-	-	RraA-like
SX1_k127_5434806_4	755731.Clo1100_2149	1.307e-37	161.0	COG0451@1|root,COG0451@2|Bacteria,1TT3X@1239|Firmicutes,24EQ3@186801|Clostridia,36VRE@31979|Clostridiaceae	186801|Clostridia	M	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
SX1_k127_5434806_3	246194.CHY_0600	7.841e-43	177.0	COG0491@1|root,COG0491@2|Bacteria,1TR4H@1239|Firmicutes,24KW2@186801|Clostridia,42IK8@68295|Thermoanaerobacterales	186801|Clostridia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SX1_k127_5434806_0	439235.Dalk_1825	1.39e-166	543.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,42N3P@68525|delta/epsilon subdivisions,2WJB7@28221|Deltaproteobacteria,2MI51@213118|Desulfobacterales	28221|Deltaproteobacteria	EG	Belongs to the IlvD Edd family	-	-	4.2.1.82,4.2.1.9	ko:K01687,ko:K22396	ko00040,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00040,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R02429,R04441,R05070	RC00468,RC00543,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
SX1_k127_5434806_2	1235798.C817_02423	1.946e-59	222.0	COG3875@1|root,COG3875@2|Bacteria,1TQ1C@1239|Firmicutes,247PH@186801|Clostridia	186801|Clostridia	S	Conserved protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
SX1_k127_5434806_5	1009370.ALO_08128	1.448e-24	114.0	COG1073@1|root,COG1073@2|Bacteria,1TQYU@1239|Firmicutes,4H524@909932|Negativicutes	909932|Negativicutes	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
SX1_k127_5434806_8	357808.RoseRS_1071	8.757e-09	61.0	COG2211@1|root,COG2211@2|Bacteria,2G6RZ@200795|Chloroflexi,3764D@32061|Chloroflexia	32061|Chloroflexia	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX1_k127_5435171_1	247490.KSU1_C0048	3.585e-52	198.0	COG2211@1|root,COG2211@2|Bacteria,2IY9C@203682|Planctomycetes	203682|Planctomycetes	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX1_k127_5435171_3	926569.ANT_17840	5.518e-12	72.0	COG0375@1|root,COG0375@2|Bacteria,2G7H5@200795|Chloroflexi	200795|Chloroflexi	C	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
SX1_k127_5435171_0	344747.PM8797T_29298	1.985e-264	832.0	COG0243@1|root,COG0243@2|Bacteria,2IXW2@203682|Planctomycetes	203682|Planctomycetes	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.7.7.2	ko:K00367,ko:K00372	ko00910,ko01120,map00910,map01120	M00531	R00791,R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
SX1_k127_5435171_2	195103.CPF_2556	3.922e-31	127.0	COG2223@1|root,COG2223@2|Bacteria,1TRS9@1239|Firmicutes,24AFE@186801|Clostridia,36DS2@31979|Clostridiaceae	186801|Clostridia	P	Major Facilitator Superfamily	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
SX1_k127_5451007_0	644282.Deba_1133	5.931e-65	228.0	COG0318@1|root,COG0318@2|Bacteria,1PW6W@1224|Proteobacteria,42PK0@68525|delta/epsilon subdivisions,2WMK6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
SX1_k127_5451007_2	3694.POPTR_0012s08160.1	0.0001385	53.0	COG0457@1|root,KOG1840@2759|Eukaryota,37N3V@33090|Viridiplantae,3G7X4@35493|Streptophyta,4JG2H@91835|fabids	35493|Streptophyta	Z	Tetratricopeptide repeat	-	GO:0001655,GO:0001822,GO:0001889,GO:0001894,GO:0001895,GO:0001947,GO:0002009,GO:0003007,GO:0003143,GO:0003205,GO:0003230,GO:0003279,GO:0003283,GO:0003341,GO:0003351,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005929,GO:0006928,GO:0006996,GO:0007017,GO:0007018,GO:0007275,GO:0007368,GO:0007369,GO:0007389,GO:0007507,GO:0008150,GO:0009653,GO:0009790,GO:0009799,GO:0009855,GO:0009887,GO:0009888,GO:0009966,GO:0009968,GO:0009987,GO:0010646,GO:0010648,GO:0016043,GO:0022603,GO:0022607,GO:0023051,GO:0023057,GO:0030030,GO:0030031,GO:0030111,GO:0030178,GO:0030323,GO:0030324,GO:0031016,GO:0032501,GO:0032502,GO:0035050,GO:0035239,GO:0035295,GO:0035469,GO:0042592,GO:0042995,GO:0043226,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0044782,GO:0045494,GO:0045595,GO:0045596,GO:0045995,GO:0048496,GO:0048513,GO:0048519,GO:0048523,GO:0048562,GO:0048565,GO:0048568,GO:0048583,GO:0048585,GO:0048598,GO:0048729,GO:0048731,GO:0048732,GO:0048856,GO:0048871,GO:0050789,GO:0050793,GO:0050794,GO:0051093,GO:0051239,GO:0051960,GO:0055123,GO:0060026,GO:0060027,GO:0060249,GO:0060271,GO:0060287,GO:0060429,GO:0060541,GO:0060562,GO:0060828,GO:0060993,GO:0061008,GO:0061371,GO:0065007,GO:0065008,GO:0070925,GO:0071840,GO:0071907,GO:0071908,GO:0071909,GO:0071910,GO:0072001,GO:0072189,GO:0072359,GO:0090090,GO:0090175,GO:0090178,GO:0120025,GO:0120031,GO:0120036,GO:1905276,GO:1905330,GO:2000026,GO:2000027,GO:2000050,GO:2000095,GO:2000167	-	-	-	-	-	-	-	-	-	-	TPR_10,TPR_12,TPR_7,TPR_8
SX1_k127_5451007_1	387631.Asulf_01189	2.845e-19	98.0	COG1250@1|root,arCOG00249@2157|Archaea,2Y84A@28890|Euryarchaeota,246RR@183980|Archaeoglobi	183980|Archaeoglobi	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
SX1_k127_5455354_0	1027292.HMPREF9372_1056	8.944e-51	194.0	COG0123@1|root,COG0123@2|Bacteria,1TQF7@1239|Firmicutes,4HBTF@91061|Bacilli,26D82@186818|Planococcaceae	1239|Firmicutes	BQ	COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
SX1_k127_5462363_1	945713.IALB_1817	3.261e-29	130.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
SX1_k127_5462363_0	1382359.JIAL01000001_gene469	1.354e-51	185.0	COG0225@1|root,COG0225@2|Bacteria,3Y4DM@57723|Acidobacteria,2JJ10@204432|Acidobacteriia	204432|Acidobacteriia	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	-	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
SX1_k127_5463032_0	1094508.Tsac_1850	1.766e-54	211.0	COG0433@1|root,COG0433@2|Bacteria,1UD3Y@1239|Firmicutes,24DTE@186801|Clostridia	186801|Clostridia	S	Domain of unknown function DUF87	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
SX1_k127_5463032_2	309801.trd_1266	9.461e-20	106.0	COG0419@1|root,COG0419@2|Bacteria,2G682@200795|Chloroflexi,27XPG@189775|Thermomicrobia	189775|Thermomicrobia	L	Rad50 zinc hook motif	-	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,Rad50_zn_hook,SbcCD_C
SX1_k127_5463032_1	1094980.Mpsy_1814	4.232e-41	159.0	COG1478@1|root,arCOG02714@2157|Archaea,2XXJZ@28890|Euryarchaeota,2N9JQ@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	F420_ligase
SX1_k127_5468286_0	1499967.BAYZ01000066_gene6055	1.916e-121	397.0	COG0169@1|root,COG0169@2|Bacteria	2|Bacteria	E	shikimate 3-dehydrogenase (NADP+) activity	aroE	GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
SX1_k127_5468286_1	1347087.CBYO010000007_gene1016	1.62e-71	246.0	COG2140@1|root,COG2140@2|Bacteria,1V4TG@1239|Firmicutes,4HGEY@91061|Bacilli	91061|Bacilli	G	Glucose-6-phosphate isomerase (GPI)	-	-	-	-	-	-	-	-	-	-	-	-	GPI
SX1_k127_5474222_0	909663.KI867150_gene1794	2.114e-108	371.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria,2MQD2@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	PFAM UvrD REP helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
SX1_k127_5474663_1	589924.Ferp_1618	2.372e-22	107.0	COG0550@1|root,arCOG01305@1|root,arCOG01305@2157|Archaea,arCOG01527@2157|Archaea,2XU6T@28890|Euryarchaeota,245NB@183980|Archaeoglobi	183980|Archaeoglobi	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
SX1_k127_5474663_0	1343739.PAP_05870	2.426e-35	151.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,243Q6@183968|Thermococci	183968|Thermococci	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2,Succ_CoA_lig
SX1_k127_5474663_2	633148.Tagg_1095	5.365e-20	91.0	COG0156@1|root,arCOG00113@2157|Archaea,2XPNA@28889|Crenarchaeota	28889|Crenarchaeota	H	pyridoxal phosphate-dependent acyltransferase	-	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
SX1_k127_5476464_0	492774.JQMB01000004_gene1989	2.149e-35	138.0	COG2020@1|root,COG2020@2|Bacteria,1R7G6@1224|Proteobacteria,2VG1Y@28211|Alphaproteobacteria,4BFP1@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
SX1_k127_5476464_1	694440.JOMF01000008_gene937	7.471e-06	57.0	arCOG01449@1|root,arCOG01449@2157|Archaea,2XSVU@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cas_Cas02710
SX1_k127_5478197_1	926569.ANT_12690	5.913e-38	155.0	COG0310@1|root,COG0310@2|Bacteria,2G6ZN@200795|Chloroflexi	200795|Chloroflexi	P	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import	-	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM,PDGLE
SX1_k127_5478197_0	263820.PTO0735	1.253e-44	177.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,241IK@183967|Thermoplasmata	183967|Thermoplasmata	O	TCP-1/cpn60 chaperonin family	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
SX1_k127_5488601_0	509191.AEDB02000075_gene2832	2.624e-60	223.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX1_k127_5491545_1	1111730.ATTM01000001_gene1476	1.236e-128	427.0	COG3525@1|root,COG3525@2|Bacteria,4NE08@976|Bacteroidetes,1HXU1@117743|Flavobacteriia,2NSHE@237|Flavobacterium	976|Bacteroidetes	G	Pfam Glycosyl hydrolase family 20, catalytic domain	-	-	3.2.1.52	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	M00079	R00022,R06004,R11316	RC00049	ko00000,ko00001,ko00002,ko01000,ko03110	-	GH20	-	CHB_HEX_C_1,F5_F8_type_C,Fn3_assoc,Glyco_hydro_20,Glyco_hydro_20b,PA14
SX1_k127_5491545_0	573063.Metin_1424	6.642e-153	497.0	COG0008@1|root,arCOG00402@2157|Archaea,2XSUM@28890|Euryarchaeota,23QIZ@183939|Methanococci	183939|Methanococci	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_2,tRNA-synt_2b
SX1_k127_5498749_2	419665.Maeo_0142	3.365e-20	95.0	COG1568@1|root,arCOG00913@2157|Archaea,2XTMN@28890|Euryarchaeota,23QA7@183939|Methanococci	183939|Methanococci	H	Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high- temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S- adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine	-	-	2.5.1.128	ko:K07057	-	-	-	-	ko00000,ko01000	-	-	-	DUF43
SX1_k127_5498749_5	374847.Kcr_0040	8.862e-07	55.0	COG4901@1|root,arCOG04327@2157|Archaea	2157|Archaea	J	30S ribosomal protein S25E	rps25e	-	-	ko:K02975	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S25
SX1_k127_5498749_1	529709.PYCH_03190	1.516e-25	111.0	COG0051@1|root,arCOG01758@2157|Archaea,2XXV8@28890|Euryarchaeota,244EN@183968|Thermococci	183968|Thermococci	J	Involved in the binding of tRNA to the ribosomes	rps10	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
SX1_k127_5498749_4	34740.HMEL006857-PA	7.197e-18	91.0	COG0500@1|root,KOG1541@2759|Eukaryota,38E9S@33154|Opisthokonta,3BBY9@33208|Metazoa,3CSCU@33213|Bilateria,41VW9@6656|Arthropoda,3SJ0C@50557|Insecta,4419J@7088|Lepidoptera	33208|Metazoa	Q	Methyltransferase involved in Williams-Beuren syndrome	WBSCR22	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0019219,GO:0019222,GO:0022613,GO:0031167,GO:0031323,GO:0031325,GO:0031974,GO:0031981,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043414,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0045935,GO:0046483,GO:0046982,GO:0046983,GO:0048471,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070013,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0080090,GO:0090069,GO:0090070,GO:0090304,GO:0140098,GO:0140102,GO:1901360,GO:2000232,GO:2000234	2.1.1.309	ko:K19306	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_11,Methyltransf_25,WBS_methylT
SX1_k127_5498749_3	221103.XP_007846101.1	1.598e-19	97.0	COG0500@1|root,KOG1541@2759|Eukaryota,38E9S@33154|Opisthokonta,3NVKK@4751|Fungi,3UXUV@5204|Basidiomycota,226ND@155619|Agaricomycetes,3W6PM@5338|Agaricales	4751|Fungi	Q	Methyltransferase involved in Williams-Beuren syndrome	BUD23	GO:0000054,GO:0000056,GO:0000154,GO:0000278,GO:0000281,GO:0000282,GO:0000447,GO:0000460,GO:0000462,GO:0000466,GO:0000469,GO:0000478,GO:0000479,GO:0000910,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006403,GO:0006405,GO:0006611,GO:0006725,GO:0006807,GO:0006810,GO:0006886,GO:0006913,GO:0007049,GO:0007163,GO:0008104,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0015031,GO:0015833,GO:0015931,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022402,GO:0022613,GO:0030010,GO:0030490,GO:0031167,GO:0031503,GO:0031974,GO:0031981,GO:0032259,GO:0033036,GO:0033750,GO:0034470,GO:0034613,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0042274,GO:0042886,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0045184,GO:0046483,GO:0046907,GO:0050657,GO:0050658,GO:0051168,GO:0051169,GO:0051179,GO:0051234,GO:0051236,GO:0051301,GO:0051640,GO:0051641,GO:0051649,GO:0051656,GO:0061640,GO:0070013,GO:0070043,GO:0070475,GO:0070476,GO:0070727,GO:0071166,GO:0071426,GO:0071428,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:0140102,GO:1901360,GO:1903047	2.1.1.309	ko:K19306	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_11,Methyltransf_25,WBS_methylT
SX1_k127_5498749_6	1151117.AJLF01000001_gene940	0.0003034	46.0	COG3609@1|root,arCOG01009@2157|Archaea,2XZXP@28890|Euryarchaeota,244NJ@183968|Thermococci	183968|Thermococci	K	Ribbon-helix-helix protein, copG family	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
SX1_k127_5498749_0	36080.S2JLC4	1.517e-103	362.0	COG1874@1|root,KOG0496@2759|Eukaryota,38D50@33154|Opisthokonta,3NZZH@4751|Fungi,1GS7S@112252|Fungi incertae sedis	4751|Fungi	G	Glycosyl hydrolases family 35	lacA	GO:0003674,GO:0003824,GO:0004553,GO:0004565,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005975,GO:0008150,GO:0008152,GO:0015925,GO:0016787,GO:0016798,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	BetaGal_dom2,BetaGal_dom3,BetaGal_dom4_5,Glyco_hydro_35
SX1_k127_5525332_8	1158338.JNLJ01000001_gene73	9.595e-10	64.0	COG2018@1|root,COG2018@2|Bacteria,2G4D2@200783|Aquificae	200783|Aquificae	S	PFAM Roadblock LC7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
SX1_k127_5525332_6	237368.SCABRO_02448	3.491e-23	107.0	COG2204@1|root,COG3829@1|root,COG2204@2|Bacteria,COG3829@2|Bacteria,2J2D8@203682|Planctomycetes	203682|Planctomycetes	KT	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_9,Response_reg,Sigma54_activat
SX1_k127_5525332_7	237368.SCABRO_00104	1.96e-10	74.0	COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	kinE	-	2.7.13.3	ko:K02491,ko:K13533,ko:K14986	ko02020,map02020	M00485,M00524	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	5TM-5TMR_LYT,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
SX1_k127_5525332_2	386456.JQKN01000008_gene1377	3.53e-57	208.0	COG0177@1|root,arCOG00459@2157|Archaea,2XTY1@28890|Euryarchaeota,23NY0@183925|Methanobacteria	183925|Methanobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
SX1_k127_5525332_4	273121.WS0471	6.794e-49	184.0	COG1387@1|root,COG1387@2|Bacteria,1RCEG@1224|Proteobacteria,42MIM@68525|delta/epsilon subdivisions,2YMFF@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	E	histidinol phosphate phosphatase	hisJ	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP,PHP_C
SX1_k127_5525332_3	760568.Desku_1027	2.616e-54	201.0	COG0491@1|root,COG0491@2|Bacteria,1UZUA@1239|Firmicutes,24CIA@186801|Clostridia,26369@186807|Peptococcaceae	186801|Clostridia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SX1_k127_5525332_1	1047013.AQSP01000128_gene457	1.92e-57	216.0	COG2848@1|root,COG2848@2|Bacteria,2NPVH@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterised ACR (DUF711)	-	-	-	ko:K09157	-	-	-	-	ko00000	-	-	-	DUF711
SX1_k127_5525332_5	273116.14324688	5.514e-32	135.0	COG1801@1|root,arCOG04291@2157|Archaea,2XY6C@28890|Euryarchaeota,2425U@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
SX1_k127_5525332_0	234267.Acid_1380	1.041e-65	236.0	COG1149@1|root,COG1149@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	ldpA	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6,LdpA_C
SX1_k127_553682_0	1365176.N186_05645	1.617e-48	186.0	COG1052@1|root,arCOG01755@2157|Archaea,2XPN8@28889|Crenarchaeota	28889|Crenarchaeota	C	D-isomer specific 2-hydroxyacid dehydrogenase catalytic	gyaR	-	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
SX1_k127_553682_1	1294265.JCM21738_4954	3.145e-25	115.0	COG4412@1|root,COG4412@2|Bacteria,1TQYP@1239|Firmicutes,4HD82@91061|Bacilli,1ZBSC@1386|Bacillus	91061|Bacilli	S	Immune inhibitor A peptidase M6	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M6
SX1_k127_5540431_2	158190.SpiGrapes_2688	2.216e-41	162.0	COG0508@1|root,COG0508@2|Bacteria	2|Bacteria	C	S-acyltransferase activity	-	-	2.3.1.12,2.7.11.1,3.6.4.13	ko:K00627,ko:K03310,ko:K03578,ko:K12132	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000,ko01001	2.A.25	-	-	2-oxoacid_dh,Biotin_lipoyl
SX1_k127_5540431_1	1123276.KB893301_gene4141	1.288e-62	233.0	COG0183@1|root,COG0183@2|Bacteria,4NE3Q@976|Bacteroidetes,47JXM@768503|Cytophagia	976|Bacteroidetes	I	Belongs to the thiolase family	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
SX1_k127_5540431_0	439235.Dalk_4717	1.904e-173	566.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,42PDA@68525|delta/epsilon subdivisions,2WK05@28221|Deltaproteobacteria,2MHS3@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
SX1_k127_5540431_3	186497.PF0593	6.574e-16	85.0	COG2248@1|root,arCOG00969@2157|Archaea,2XW12@28890|Euryarchaeota,24350@183968|Thermococci	183968|Thermococci	S	Belongs to the UPF0282 family	-	-	-	ko:K07022	-	-	-	-	ko00000	-	-	-	Lactamase_B_2
SX1_k127_5552716_4	1235793.C809_02624	0.0001627	48.0	COG1961@1|root,COG1961@2|Bacteria,1TS5B@1239|Firmicutes,248MZ@186801|Clostridia,27KAN@186928|unclassified Lachnospiraceae	186801|Clostridia	L	Recombinase zinc beta ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
SX1_k127_5552716_2	926569.ANT_22340	3.311e-46	184.0	COG2211@1|root,COG2211@2|Bacteria,2G6RZ@200795|Chloroflexi	200795|Chloroflexi	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX1_k127_5552716_0	224325.AF_1815	1.213e-108	366.0	COG4992@1|root,arCOG00914@2157|Archaea,2XTKV@28890|Euryarchaeota,24610@183980|Archaeoglobi	28890|Euryarchaeota	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	lysJ	GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	-	ko:K05830	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00031,M00763	R09778,R10932	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SX1_k127_5552716_3	9818.XP_007936538.1	1.28e-06	54.0	KOG0254@1|root,KOG0254@2759|Eukaryota,38HZ7@33154|Opisthokonta,3BFPM@33208|Metazoa,3CWAI@33213|Bilateria,483FY@7711|Chordata,494IJ@7742|Vertebrata,3J6A2@40674|Mammalia,34TMM@311790|Afrotheria	33208|Metazoa	U	Solute carrier family 2, facilitated glucose transporter member 10	SLC2A10	GO:0003674,GO:0005215,GO:0005351,GO:0005355,GO:0005402,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008643,GO:0008645,GO:0015075,GO:0015077,GO:0015078,GO:0015144,GO:0015145,GO:0015149,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0015749,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034219,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046323,GO:0051119,GO:0051179,GO:0051234,GO:0055056,GO:0055085,GO:0071702,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600,GO:1904659	-	ko:K08147,ko:K08149	-	-	-	-	ko00000,ko02000	2.A.1.1,2.A.1.1.59	-	-	Sugar_tr
SX1_k127_5574331_4	1210884.HG799462_gene8369	1.025e-91	308.0	COG2057@1|root,COG2057@2|Bacteria	2|Bacteria	I	CoA-transferase activity	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
SX1_k127_5574331_2	273068.TTE0722	1.362e-159	510.0	COG0604@1|root,COG0604@2|Bacteria,1TQ4W@1239|Firmicutes,249C7@186801|Clostridia,42I20@68295|Thermoanaerobacterales	186801|Clostridia	C	alcohol dehydrogenase	kdd	-	1.4.1.11	ko:K18012	ko00310,map00310	-	R03349	RC00888	ko00000,ko00001,ko01000	-	-	-	ADH_zinc_N
SX1_k127_5574331_1	857293.CAAU_1573	2.231e-194	613.0	COG1509@1|root,COG1509@2|Bacteria,1TQQZ@1239|Firmicutes,249JV@186801|Clostridia,36E9A@31979|Clostridiaceae	186801|Clostridia	E	lysine 2,3-aminomutase YodO family protein	ablA	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,LAM_C,Radical_SAM
SX1_k127_5574331_5	1540257.JQMW01000011_gene2333	6.504e-84	290.0	2C3VR@1|root,2Z9AE@2|Bacteria,1UZNB@1239|Firmicutes,24D9F@186801|Clostridia,36FQA@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_5574331_0	273068.TTE0726	6.3e-235	736.0	COG0274@1|root,COG0274@2|Bacteria,1TPA0@1239|Firmicutes,249YN@186801|Clostridia,42I4U@68295|Thermoanaerobacterales	186801|Clostridia	F	D-Lysine 5,6-aminomutase alpha subunit	kamD	-	5.4.3.3	ko:K01844	ko00310,map00310	-	R02852,R03275	RC00719	ko00000,ko00001,ko01000	-	-	-	Lys-AminoMut_A
SX1_k127_5574331_3	857293.CAAU_1577	1.92e-101	336.0	COG2185@1|root,COG2185@2|Bacteria,1TS6G@1239|Firmicutes,24AG8@186801|Clostridia,36UK1@31979|Clostridiaceae	186801|Clostridia	I	Dimerisation domain of d-ornithine 4,5-aminomutase	kamE	-	5.4.3.3	ko:K18011	ko00310,map00310	-	R02852,R03275	RC00719	ko00000,ko00001,ko01000	-	-	-	B12-binding,OAM_dimer
SX1_k127_5574331_6	439481.Aboo_1375	2.967e-16	92.0	COG0608@1|root,arCOG00427@2157|Archaea,2XW5A@28890|Euryarchaeota,3F2M1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	DHHA1 domain	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHH,DHHA1
SX1_k127_5574331_7	273057.SSO0213	7.652e-09	67.0	COG1665@1|root,arCOG01831@2157|Archaea,2XRA4@28889|Crenarchaeota	28889|Crenarchaeota	S	DNA polymerase beta domain protein region	-	-	-	ko:K09717	-	-	-	-	ko00000	-	-	-	NTP_transf_2
SX1_k127_5574331_8	386456.JQKN01000003_gene373	1.84e-08	60.0	COG1872@1|root,arCOG04058@2157|Archaea,2XZV9@28890|Euryarchaeota,23PVJ@183925|Methanobacteria	183925|Methanobacteria	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
SX1_k127_5574331_9	339860.Msp_0626	0.00027	48.0	COG1412@1|root,arCOG04312@2157|Archaea,2Y1JB@28890|Euryarchaeota,23PR1@183925|Methanobacteria	183925|Methanobacteria	S	Nucleotide binding protein, PINc	-	-	-	ko:K07158	-	-	-	-	ko00000	-	-	-	-
SX1_k127_5600173_11	748727.CLJU_c19570	1.925e-22	102.0	COG0716@1|root,COG0716@2|Bacteria,1VBEZ@1239|Firmicutes,24JJ6@186801|Clostridia,36K16@31979|Clostridiaceae	186801|Clostridia	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_4,Flavodoxin_5
SX1_k127_5600173_5	706587.Desti_5358	1.031e-67	248.0	COG0277@1|root,COG0277@2|Bacteria,1MY08@1224|Proteobacteria,42Q28@68525|delta/epsilon subdivisions,2X5UF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
SX1_k127_5600173_4	565033.GACE_1903	3.136e-81	284.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota,245SC@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S dicluster domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_17
SX1_k127_5600173_13	1121405.dsmv_1502	2.336e-13	75.0	COG1765@1|root,COG1765@2|Bacteria,1N1T3@1224|Proteobacteria,42UFR@68525|delta/epsilon subdivisions,2WQ83@28221|Deltaproteobacteria,2MMSD@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
SX1_k127_5600173_1	573064.Mefer_0155	2.501e-202	645.0	COG1229@1|root,arCOG04461@2157|Archaea,2XV5V@28890|Euryarchaeota,23QNZ@183939|Methanococci	183939|Methanococci	C	PFAM Amidohydrolase 3	fwdA	-	1.2.7.12	ko:K00200	ko00680,ko01100,ko01120,ko01130,ko01200,map00680,map01100,map01120,map01130,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_3
SX1_k127_5600173_9	634498.mru_0816	1.382e-46	175.0	COG2048@1|root,arCOG00964@2157|Archaea,2XXYP@28890|Euryarchaeota,23NZ8@183925|Methanobacteria	183925|Methanobacteria	C	reductase, subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_8
SX1_k127_5600173_3	573063.Metin_0496	2.501e-93	316.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23Q7G@183939|Methanococci	183939|Methanococci	C	heterodisulfide reductase	hdrB1	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
SX1_k127_5600173_0	579137.Metvu_0714	1.756e-256	806.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23QA9@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
SX1_k127_5600173_8	1121422.AUMW01000038_gene3025	5.393e-48	176.0	COG1908@1|root,COG1908@2|Bacteria,1V7I6@1239|Firmicutes,24JV2@186801|Clostridia,261SC@186807|Peptococcaceae	186801|Clostridia	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
SX1_k127_5600173_15	706587.Desti_1829	5.602e-08	57.0	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,42M3T@68525|delta/epsilon subdivisions,2WIV8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	electron transfer flavoprotein, alpha subunit	-	-	1.3.1.108	ko:K03522,ko:K22432	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	ETF,ETF_alpha
SX1_k127_5600173_10	679926.Mpet_2480	4.194e-27	120.0	COG1145@1|root,arCOG02180@2157|Archaea,2XV84@28890|Euryarchaeota,2N9ND@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	fwdF-1	-	-	ko:K00205	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002	-	-	-	Fer4,Fer4_4,Fer4_7
SX1_k127_5600173_7	410358.Mlab_0246	8.324e-49	184.0	COG2218@1|root,arCOG00097@2157|Archaea,2XWD0@28890|Euryarchaeota,2N9RN@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM glutamate synthase alpha subunit domain protein	fwdC-1	-	1.2.7.12	ko:K00202	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	GXGXG
SX1_k127_5600173_6	1094980.Mpsy_2940	3.869e-64	226.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,2N9AI@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	hdrA-2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_17,Fer4_7,Fer4_9,Pyr_redox_2
SX1_k127_5600173_2	579137.Metvu_1485	1.523e-138	453.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23QK4@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
SX1_k127_5600173_14	419665.Maeo_1213	1.137e-11	65.0	COG1908@1|root,arCOG02475@2157|Archaea,2XXAU@28890|Euryarchaeota,23QYD@183939|Methanococci	183939|Methanococci	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
SX1_k127_5600173_16	477974.Daud_0115	1.675e-05	50.0	COG1908@1|root,COG1908@2|Bacteria,1V638@1239|Firmicutes,24J0E@186801|Clostridia,261V3@186807|Peptococcaceae	186801|Clostridia	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	FlpD
SX1_k127_5600173_17	5722.XP_001325482.1	0.0002133	52.0	28IF7@1|root,2QQS1@2759|Eukaryota	2759|Eukaryota	H	inositol tetrakisphosphate 1-kinase activity	ITPK1	GO:0000003,GO:0000166,GO:0000825,GO:0003006,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0006950,GO:0007275,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009611,GO:0009791,GO:0009987,GO:0010154,GO:0010214,GO:0010264,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0017076,GO:0017144,GO:0019637,GO:0019751,GO:0022414,GO:0030554,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032958,GO:0033517,GO:0035639,GO:0036094,GO:0042578,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046173,GO:0046835,GO:0047325,GO:0047484,GO:0048316,GO:0048583,GO:0048608,GO:0048731,GO:0048856,GO:0050789,GO:0050896,GO:0051717,GO:0051765,GO:0051766,GO:0052725,GO:0052726,GO:0052743,GO:0052745,GO:0052746,GO:0061458,GO:0065007,GO:0071704,GO:0080134,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576,GO:1901615,GO:1901617	2.7.1.134,2.7.1.159	ko:K00913	ko00562,ko01100,ko04070,map00562,map01100,map04070	M00132	R03428,R03429,R03479	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Ins134_P3_kin
SX1_k127_5600173_12	368408.Tpen_0305	4.566e-16	86.0	COG1047@1|root,arCOG00980@2157|Archaea,2XQ07@28889|Crenarchaeota	28889|Crenarchaeota	O	peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
SX1_k127_5602767_0	224325.AF_0267	0.0002962	49.0	arCOG06935@1|root,arCOG06935@2157|Archaea,2Y5IP@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_560703_2	332101.JIBU02000006_gene463	1.204e-36	147.0	COG1600@1|root,COG1600@2|Bacteria	2|Bacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Fer4_16
SX1_k127_560703_1	1195236.CTER_0694	6.194e-46	178.0	COG1600@1|root,COG1600@2|Bacteria	2|Bacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Fer4_16
SX1_k127_560703_3	1347086.CCBA010000009_gene1329	4.801e-11	77.0	COG0627@1|root,COG0627@2|Bacteria	2|Bacteria	J	Serine hydrolase involved in the detoxification of formaldehyde	-	-	-	-	-	-	-	-	-	-	-	-	Esterase,Hepar_II_III,Hepar_II_III_N,OprD
SX1_k127_560703_0	1219084.AP014508_gene1560	3.115e-58	220.0	COG2211@1|root,COG2211@2|Bacteria,2GDVW@200918|Thermotogae	200918|Thermotogae	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX1_k127_5615465_2	945713.IALB_1371	2.824e-09	57.0	COG2067@1|root,COG2067@2|Bacteria	2|Bacteria	I	long-chain fatty acid transporting porin activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_5615465_0	945713.IALB_1372	2.918e-272	869.0	COG1520@1|root,COG4412@1|root,COG1520@2|Bacteria,COG4412@2|Bacteria	2|Bacteria	S	peptidase activity, acting on L-amino acid peptides	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,HATPase_c,PQQ_2,PQQ_3,Peptidase_C25,SLH,Y_Y_Y
SX1_k127_5615465_1	1191523.MROS_1891	4.942e-245	763.0	COG0729@1|root,COG0823@1|root,COG0729@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	treP	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,PD40
SX1_k127_5622151_1	1384049.CD29_08765	1.113e-41	160.0	COG0703@1|root,COG0703@2|Bacteria,1V25K@1239|Firmicutes,4HFS0@91061|Bacilli	91061|Bacilli	E	Shikimate kinase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_18
SX1_k127_5622151_0	1385935.N836_04355	1.416e-70	249.0	COG1893@1|root,COG1893@2|Bacteria	2|Bacteria	H	2-dehydropantoate 2-reductase activity	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA
SX1_k127_5622151_2	391009.Tmel_0097	3.994e-22	102.0	COG1363@1|root,COG1363@2|Bacteria,2GC7V@200918|Thermotogae	200918|Thermotogae	G	PFAM peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
SX1_k127_5625558_1	515635.Dtur_0699	5.079e-123	406.0	COG0156@1|root,COG0156@2|Bacteria	2|Bacteria	E	8-amino-7-oxononanoate synthase activity	bioF	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
SX1_k127_5625558_0	1304880.JAGB01000001_gene244	7.891e-212	689.0	COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,248GI@186801|Clostridia	186801|Clostridia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
SX1_k127_5625558_9	688269.Theth_1996	6.552e-20	94.0	COG2164@1|root,COG2164@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K09143	-	-	-	-	ko00000	-	-	-	Cyclophil_like
SX1_k127_5625558_4	1280390.CBQR020000036_gene772	2.645e-52	201.0	COG2211@1|root,COG2211@2|Bacteria,1UZ21@1239|Firmicutes	1239|Firmicutes	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX1_k127_5625558_5	749414.SBI_02612	1.577e-31	141.0	COG1233@1|root,COG1233@2|Bacteria,2GP0A@201174|Actinobacteria	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	-	-	5.2.1.13	ko:K09835	ko00906,ko01100,ko01110,map00906,map01100,map01110	M00097	R07512	RC01960	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
SX1_k127_5625558_8	1183377.Py04_1082	1.607e-27	119.0	COG1014@1|root,arCOG01603@2157|Archaea,2XVFR@28890|Euryarchaeota,243DZ@183968|Thermococci	183968|Thermococci	C	pyruvate synthase activity	porG	-	1.2.7.1,1.2.7.7	ko:K00172,ko:K00189	ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R07160,R08034,R08566,R08567	RC00004,RC00250,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
SX1_k127_5625558_6	1121918.ARWE01000001_gene3074	9.527e-31	123.0	COG1144@1|root,COG1144@2|Bacteria,1NE6F@1224|Proteobacteria,42W4G@68525|delta/epsilon subdivisions,2WS1A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	oxidoreductase, delta subunit	-	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
SX1_k127_5625558_2	523850.TON_1478	2.097e-103	350.0	COG0674@1|root,arCOG01608@2157|Archaea,2XTB0@28890|Euryarchaeota,242N1@183968|Thermococci	183968|Thermococci	C	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity	vorA	-	1.2.7.7	ko:K00186	ko00280,ko01100,map00280,map01100	-	R07160,R08566,R08567	RC00004,RC02833,RC02856	br01601,ko00000,ko00001,ko01000	-	-	-	PFOR_II,POR_N
SX1_k127_5625558_3	335543.Sfum_0114	2.717e-87	298.0	COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,42MQY@68525|delta/epsilon subdivisions,2WJGJ@28221|Deltaproteobacteria,2MREB@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM thiamine pyrophosphate enzyme	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
SX1_k127_5625558_7	1121904.ARBP01000005_gene4616	6.655e-29	119.0	COG2128@1|root,COG2128@2|Bacteria	2|Bacteria	S	hydroperoxide reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
SX1_k127_5634634_3	1128398.Curi_c17090	8.884e-25	109.0	COG4087@1|root,COG4087@2|Bacteria,1VA72@1239|Firmicutes,24N3C@186801|Clostridia,26BQ0@186813|unclassified Clostridiales	186801|Clostridia	S	Soluble P-type ATPase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase,Hydrolase_3
SX1_k127_5634634_1	1128421.JAGA01000002_gene1337	7.035e-42	169.0	COG2242@1|root,COG2242@2|Bacteria	2|Bacteria	H	protein methyltransferase activity	-	-	2.1.1.242,2.1.1.303,2.1.1.319	ko:K11434,ko:K15984,ko:K20421	ko01059,ko01130,ko04068,ko04922,map01059,map01130,map04068,map04922	M00830	R10963,R11216,R11217,R11219	RC00003,RC00392,RC02120,RC03388,RC03390	ko00000,ko00001,ko00002,ko01000,ko03009,ko03036	-	-	-	DOT1,Methyltransf_21,Methyltransf_25
SX1_k127_5634634_2	945713.IALB_0524	3.917e-39	171.0	COG2373@1|root,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,Thiol-ester_cl
SX1_k127_5634634_0	304371.MCP_0646	2.451e-47	178.0	COG2013@1|root,arCOG01907@2157|Archaea,2XW0I@28890|Euryarchaeota,2N9P0@224756|Methanomicrobia	224756|Methanomicrobia	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
SX1_k127_5639518_1	1280380.KR100_10480	6.39e-11	71.0	COG2516@1|root,COG2516@2|Bacteria,1G28Q@1117|Cyanobacteria,1GZK1@1129|Synechococcus	1117|Cyanobacteria	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SX1_k127_5639518_0	4555.Si026830m	4.105e-34	138.0	COG0197@1|root,KOG0857@2759|Eukaryota,37R0X@33090|Viridiplantae,3GA33@35493|Streptophyta,3M9FV@4447|Liliopsida,3IM35@38820|Poales	35493|Streptophyta	J	Ribosomal protein L16p/L10e	-	GO:0000027,GO:0002252,GO:0002376,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005737,GO:0005773,GO:0005774,GO:0005829,GO:0005840,GO:0005844,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006952,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009507,GO:0009526,GO:0009536,GO:0009605,GO:0009607,GO:0009615,GO:0009628,GO:0009941,GO:0009987,GO:0010224,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031090,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032502,GO:0032991,GO:0034622,GO:0034641,GO:0034644,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0042788,GO:0043043,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044428,GO:0044434,GO:0044435,GO:0044437,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0051607,GO:0051704,GO:0051707,GO:0051716,GO:0065003,GO:0070013,GO:0070925,GO:0071214,GO:0071478,GO:0071482,GO:0071493,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098542,GO:0098588,GO:0098805,GO:0104004,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02866	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
SX1_k127_5639518_2	391623.TERMP_00738	4.99e-06	57.0	COG0143@1|root,arCOG00810@2157|Archaea,2XTG5@28890|Euryarchaeota,242K4@183968|Thermococci	183968|Thermococci	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
SX1_k127_5641566_1	760011.Spico_1067	6.507e-25	111.0	COG2211@1|root,COG2211@2|Bacteria,2JAUS@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX1_k127_5641566_0	1167006.UWK_01125	7.584e-239	754.0	COG0427@1|root,COG0454@1|root,COG0427@2|Bacteria,COG0456@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria,2MMNB@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Acetyl-CoA hydrolase/transferase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1
SX1_k127_5648363_0	610130.Closa_2787	1.171e-175	595.0	COG0714@1|root,COG1112@1|root,COG0714@2|Bacteria,COG1112@2|Bacteria,1TP20@1239|Firmicutes,24BMH@186801|Clostridia,221FY@1506553|Lachnoclostridium	186801|Clostridia	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12,DUF3320,DUF4011,DUF559
SX1_k127_564915_0	877455.Metbo_2366	3.109e-31	138.0	COG0644@1|root,arCOG00570@2157|Archaea,2XUI9@28890|Euryarchaeota,23NUG@183925|Methanobacteria	183925|Methanobacteria	C	Lycopene cyclase protein	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,Lycopene_cycl
SX1_k127_564915_1	477974.Daud_1179	4.194e-15	86.0	COG0204@1|root,COG0204@2|Bacteria,1U8N2@1239|Firmicutes,25B02@186801|Clostridia,261WZ@186807|Peptococcaceae	186801|Clostridia	I	TIGRFAM 1-acyl-sn-glycerol-3-phosphate acyltransferases	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
SX1_k127_564915_2	273068.TTE0315	1.063e-09	70.0	COG2234@1|root,COG2234@2|Bacteria,1UZC9@1239|Firmicutes,24FE4@186801|Clostridia,42ER5@68295|Thermoanaerobacterales	186801|Clostridia	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
SX1_k127_564915_3	796606.BMMGA3_01140	1.306e-05	51.0	COG3315@1|root,COG3315@2|Bacteria,1TR1Q@1239|Firmicutes,4IPTY@91061|Bacilli,1ZHVZ@1386|Bacillus	91061|Bacilli	H	Leucine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	LCM
SX1_k127_564915_4	1105031.HMPREF1141_1744	2.443e-05	47.0	COG3315@1|root,COG3315@2|Bacteria,1TR1Q@1239|Firmicutes,24BWW@186801|Clostridia,36JNS@31979|Clostridiaceae	186801|Clostridia	Q	Leucine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	LCM
SX1_k127_5660190_7	743719.PaelaDRAFT_1213	6.425e-05	55.0	COG4733@1|root,COG4733@2|Bacteria,1TXSD@1239|Firmicutes,4I0BE@91061|Bacilli,271I2@186822|Paenibacillaceae	91061|Bacilli	S	Heparinase II/III-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Hepar_II_III
SX1_k127_5660190_2	1233951.IO90_01490	6.966e-31	137.0	COG1721@1|root,COG1721@2|Bacteria,4NE10@976|Bacteroidetes,1HXIV@117743|Flavobacteriia	976|Bacteroidetes	S	protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
SX1_k127_5660190_0	246969.TAM4_1790	8.945e-98	338.0	COG0423@1|root,arCOG00405@2157|Archaea,2XSZK@28890|Euryarchaeota,242X6@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
SX1_k127_5660190_3	289377.HL41_04520	5.509e-27	119.0	COG0778@1|root,COG0778@2|Bacteria,2GHHZ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SX1_k127_5660190_5	768704.Desmer_1384	1.092e-10	73.0	COG0491@1|root,COG0491@2|Bacteria,1TQPX@1239|Firmicutes,24BDQ@186801|Clostridia,261Z4@186807|Peptococcaceae	186801|Clostridia	S	Zn-dependent hydrolase, glyoxylase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SX1_k127_5660190_6	1293047.CBMA010000053_gene3344	8.305e-07	58.0	2DZAE@1|root,2N5T3@2157|Archaea,2Y3PF@28890|Euryarchaeota,23ZME@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_5660190_1	592015.HMPREF1705_00650	1.088e-73	260.0	COG2516@1|root,COG2516@2|Bacteria,3TB3Y@508458|Synergistetes	508458|Synergistetes	S	Radical SAM domain protein	-	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
SX1_k127_5660190_4	592015.HMPREF1705_00648	4.15e-11	64.0	COG0095@1|root,COG0095@2|Bacteria,3TBDG@508458|Synergistetes	508458|Synergistetes	H	PFAM Biotin lipoate A B protein ligase family	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
SX1_k127_5666351_1	868131.MSWAN_0503	9.035e-120	411.0	COG1202@1|root,arCOG00554@2157|Archaea,arCOG03143@2157|Archaea,2XUCK@28890|Euryarchaeota,23NWH@183925|Methanobacteria	183925|Methanobacteria	L	PFAM DNA RNA helicase, DEAD DEAH box type, N-terminal	-	-	-	ko:K03725	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,Helicase_C
SX1_k127_5666351_16	592028.GCWU000321_00896	1.203e-05	59.0	COG0577@1|root,COG0577@2|Bacteria,1TUYK@1239|Firmicutes,4H21N@909932|Negativicutes	909932|Negativicutes	V	Efflux ABC transporter, permease protein	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX1_k127_5666351_18	267377.MMP0871	0.0004334	54.0	COG0577@1|root,arCOG02312@2157|Archaea,2XUEE@28890|Euryarchaeota,23RIZ@183939|Methanococci	183939|Methanococci	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX1_k127_5666351_7	439481.Aboo_0478	1.127e-61	222.0	COG1136@1|root,arCOG00922@2157|Archaea,2XUH3@28890|Euryarchaeota,3F2R8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	ABC transporter	yvrO-2	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX1_k127_5666351_11	909663.KI867150_gene1262	7.126e-40	154.0	COG1751@1|root,COG1751@2|Bacteria,1NERB@1224|Proteobacteria,42W3N@68525|delta/epsilon subdivisions,2WS20@28221|Deltaproteobacteria,2MS0Q@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	PFAM Pyruvate kinase, alpha beta domain	-	-	-	ko:K09126	-	-	-	-	ko00000	-	-	-	PK_C
SX1_k127_5666351_5	553973.CLOHYLEM_03982	3.294e-81	279.0	COG0190@1|root,COG0190@2|Bacteria,1TP1P@1239|Firmicutes,248DB@186801|Clostridia,21Z0X@1506553|Lachnoclostridium	186801|Clostridia	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
SX1_k127_5666351_6	9365.XP_007516954.1	3.858e-68	252.0	COG5277@1|root,KOG0676@2759|Eukaryota,3AFWH@33154|Opisthokonta,3BYBY@33208|Metazoa,3D2JU@33213|Bilateria,489WR@7711|Chordata,4928Q@7742|Vertebrata,3J869@40674|Mammalia	33208|Metazoa	Z	ATP binding	ACTBL2	-	-	-	-	-	-	-	-	-	-	-	Actin
SX1_k127_5666351_2	416591.Tlet_1877	2.304e-101	344.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	MA20_02630	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX1_k127_5666351_17	69319.XP_008556922.1	2.58e-05	55.0	KOG4068@1|root,KOG4068@2759|Eukaryota,39S7B@33154|Opisthokonta,3B9CD@33208|Metazoa,3CVUB@33213|Bilateria,41ZA4@6656|Arthropoda,3SMEY@50557|Insecta,46JQ2@7399|Hymenoptera	33208|Metazoa	S	ESCRT-II complex subunit	VPS25	GO:0000003,GO:0000578,GO:0000814,GO:0001894,GO:0001932,GO:0001933,GO:0002009,GO:0002165,GO:0003002,GO:0003006,GO:0003674,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005829,GO:0006403,GO:0006469,GO:0006508,GO:0006511,GO:0006807,GO:0006810,GO:0006886,GO:0006897,GO:0006914,GO:0006996,GO:0007032,GO:0007034,GO:0007163,GO:0007175,GO:0007176,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007308,GO:0007309,GO:0007314,GO:0007350,GO:0007351,GO:0007389,GO:0007444,GO:0007483,GO:0007484,GO:0007485,GO:0007548,GO:0007552,GO:0007560,GO:0008104,GO:0008150,GO:0008152,GO:0008283,GO:0008285,GO:0008298,GO:0008358,GO:0008593,GO:0008595,GO:0009056,GO:0009057,GO:0009653,GO:0009790,GO:0009791,GO:0009798,GO:0009880,GO:0009886,GO:0009887,GO:0009888,GO:0009892,GO:0009948,GO:0009952,GO:0009966,GO:0009968,GO:0009987,GO:0009994,GO:0010008,GO:0010256,GO:0010469,GO:0010563,GO:0010605,GO:0010646,GO:0010648,GO:0010669,GO:0010941,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0016197,GO:0016236,GO:0019220,GO:0019222,GO:0019538,GO:0019941,GO:0019953,GO:0021700,GO:0022411,GO:0022412,GO:0022414,GO:0022607,GO:0023051,GO:0023057,GO:0030011,GO:0030154,GO:0030163,GO:0030539,GO:0031090,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0031410,GO:0031974,GO:0031981,GO:0031982,GO:0032268,GO:0032269,GO:0032501,GO:0032502,GO:0032504,GO:0032509,GO:0032511,GO:0032984,GO:0032991,GO:0033036,GO:0033365,GO:0033673,GO:0034613,GO:0035088,GO:0035090,GO:0035112,GO:0035126,GO:0035215,GO:0035239,GO:0035282,GO:0035295,GO:0036257,GO:0036258,GO:0036452,GO:0042058,GO:0042059,GO:0042127,GO:0042325,GO:0042326,GO:0042592,GO:0042802,GO:0042803,GO:0042886,GO:0042981,GO:0043067,GO:0043086,GO:0043162,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043328,GO:0043549,GO:0043632,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045184,GO:0045197,GO:0045199,GO:0045324,GO:0045450,GO:0045859,GO:0045936,GO:0046661,GO:0046907,GO:0046983,GO:0047485,GO:0048468,GO:0048469,GO:0048477,GO:0048513,GO:0048519,GO:0048523,GO:0048563,GO:0048569,GO:0048583,GO:0048585,GO:0048599,GO:0048608,GO:0048609,GO:0048707,GO:0048729,GO:0048731,GO:0048803,GO:0048805,GO:0048806,GO:0048808,GO:0048856,GO:0048869,GO:0048871,GO:0050678,GO:0050680,GO:0050730,GO:0050732,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051174,GO:0051179,GO:0051234,GO:0051246,GO:0051248,GO:0051338,GO:0051348,GO:0051603,GO:0051641,GO:0051649,GO:0051704,GO:0060249,GO:0060255,GO:0060429,GO:0060562,GO:0060810,GO:0060811,GO:0061097,GO:0061099,GO:0061245,GO:0061458,GO:0061919,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070086,GO:0070727,GO:0070925,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071985,GO:0072594,GO:0072665,GO:0072666,GO:0080090,GO:0090598,GO:0097352,GO:0097708,GO:0098588,GO:0098657,GO:0098796,GO:0098805,GO:1901184,GO:1901185,GO:1901564,GO:1901565,GO:1901575,GO:2000272	-	ko:K12189	ko04144,map04144	M00410	-	-	ko00000,ko00001,ko00002,ko04131,ko04147	-	-	-	ESCRT-II
SX1_k127_5666351_4	5482.XP_002551260.1	6.824e-85	296.0	KOG0739@1|root,KOG0739@2759|Eukaryota,38D1Q@33154|Opisthokonta,3NUSN@4751|Fungi,3QKW5@4890|Ascomycota,3RRS6@4891|Saccharomycetes,47CMJ@766764|Debaryomycetaceae	4751|Fungi	O	Belongs to the AAA ATPase family	VPS4	GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005768,GO:0005783,GO:0006508,GO:0006511,GO:0006605,GO:0006623,GO:0006629,GO:0006807,GO:0006810,GO:0006886,GO:0006900,GO:0006914,GO:0006996,GO:0006997,GO:0006998,GO:0007032,GO:0007033,GO:0007034,GO:0008104,GO:0008144,GO:0008150,GO:0008152,GO:0008202,GO:0009056,GO:0009057,GO:0009306,GO:0009405,GO:0009987,GO:0010035,GO:0010038,GO:0010226,GO:0010256,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016050,GO:0016125,GO:0016192,GO:0016197,GO:0016236,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019941,GO:0022607,GO:0030163,GO:0030447,GO:0030448,GO:0030554,GO:0031410,GO:0031982,GO:0032507,GO:0032509,GO:0032511,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0033036,GO:0033365,GO:0034067,GO:0034613,GO:0035639,GO:0036094,GO:0040007,GO:0042221,GO:0042802,GO:0042803,GO:0042886,GO:0043162,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043328,GO:0043632,GO:0043933,GO:0044085,GO:0044182,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045053,GO:0045184,GO:0045185,GO:0045324,GO:0046903,GO:0046907,GO:0046983,GO:0050896,GO:0051179,GO:0051234,GO:0051235,GO:0051259,GO:0051260,GO:0051603,GO:0051641,GO:0051649,GO:0051651,GO:0051704,GO:0051716,GO:0061024,GO:0061919,GO:0065003,GO:0065007,GO:0065008,GO:0070676,GO:0070727,GO:0070887,GO:0071241,GO:0071248,GO:0071285,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071985,GO:0072594,GO:0072665,GO:0072666,GO:0097159,GO:0097367,GO:0097708,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901615	-	ko:K12196	ko04144,ko04217,map04144,map04217	M00412	-	-	ko00000,ko00001,ko00002,ko04131	-	-	-	AAA,MIT,Vps4_C
SX1_k127_5666351_12	5141.EFNCRP00000003712	1.335e-32	138.0	COG1218@1|root,KOG1528@2759|Eukaryota,38CH8@33154|Opisthokonta,3NU2N@4751|Fungi,3QKPZ@4890|Ascomycota,213P9@147550|Sordariomycetes,3U5D8@5139|Sordariales,3UK83@5148|Sordariaceae	4751|Fungi	FP	Inositol monophosphatase family	MET22	GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0003824,GO:0004441,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006970,GO:0006972,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008252,GO:0008441,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009628,GO:0009651,GO:0009987,GO:0016053,GO:0016311,GO:0016312,GO:0016787,GO:0016788,GO:0016791,GO:0019752,GO:0023052,GO:0035556,GO:0042538,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046030,GO:0046394,GO:0048015,GO:0048017,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052829,GO:0065007,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Inositol_P
SX1_k127_5666351_9	1469607.KK073768_gene1888	1.842e-45	174.0	COG1058@1|root,COG1058@2|Bacteria	2|Bacteria	S	Probable molybdopterin binding domain	cinA	-	3.5.1.42	ko:K03742	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
SX1_k127_5666351_14	56780.SYN_02452	2.788e-19	90.0	COG0694@1|root,COG0694@2|Bacteria,1MVQ1@1224|Proteobacteria,42V85@68525|delta/epsilon subdivisions,2WR93@28221|Deltaproteobacteria,2MS8K@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	NifU-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Nfu_N,NifU
SX1_k127_5666351_0	1173027.Mic7113_5594	1.172e-136	441.0	COG0057@1|root,COG0057@2|Bacteria,1G1CS@1117|Cyanobacteria,1H7J0@1150|Oscillatoriales	1117|Cyanobacteria	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	-	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
SX1_k127_5666351_3	243232.MJ_0641	5.039e-95	325.0	COG0126@1|root,arCOG00496@2157|Archaea,2XSXX@28890|Euryarchaeota,23QGF@183939|Methanococci	183939|Methanococci	G	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
SX1_k127_5666351_10	1121897.AUGO01000004_gene1033	1.116e-42	171.0	COG0111@1|root,COG0111@2|Bacteria,4NE9J@976|Bacteroidetes	976|Bacteroidetes	EH	PFAM D-isomer specific 2-hydroxyacid dehydrogenase	ghrA	-	1.1.1.79,1.1.1.81	ko:K12972	ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00260,map00620,map00630,map01100,map01110,map01120	-	R00465,R01388,R01392,R02527	RC00031,RC00042,RC00670	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh_C
SX1_k127_5666351_8	56780.SYN_00049	1.903e-61	229.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42NET@68525|delta/epsilon subdivisions,2WKDX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	CoA binding domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
SX1_k127_5666351_15	1080067.BAZH01000034_gene2030	4.838e-16	88.0	COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,1S3QD@1236|Gammaproteobacteria,3WWCV@544|Citrobacter	1236|Gammaproteobacteria	G	haloacid dehalogenase-like hydrolase	gph	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0031404,GO:0033554,GO:0034641,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	iSBO_1134.SBO_3372,iSbBS512_1146.SbBS512_E3762,iYL1228.KPN_03756	HAD_2
SX1_k127_5666351_13	879212.DespoDRAFT_00561	1.561e-22	108.0	COG2204@1|root,COG3829@1|root,COG2204@2|Bacteria,COG3829@2|Bacteria,1MU0N@1224|Proteobacteria,43BK2@68525|delta/epsilon subdivisions,2X6XX@28221|Deltaproteobacteria,2MPNK@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM Response regulator receiver domain	-	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,PAS_4,PAS_9,Response_reg,Sigma54_activat
SX1_k127_5686960_0	1340434.AXVA01000003_gene1884	2.451e-206	655.0	COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,4HA2X@91061|Bacilli,1ZCFH@1386|Bacillus	91061|Bacilli	F	Belongs to the formate--tetrahydrofolate ligase family	fhs	GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
SX1_k127_5686960_1	1499967.BAYZ01000105_gene3489	5.438e-190	601.0	COG1882@1|root,COG1882@2|Bacteria,2NQDK@2323|unclassified Bacteria	2|Bacteria	C	Pyruvate formate lyase-like	pflD	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
SX1_k127_5688795_1	1047013.AQSP01000142_gene242	4.796e-39	150.0	COG2511@1|root,COG2511@2|Bacteria	2|Bacteria	J	GatB/GatE catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	GatB_N
SX1_k127_5688795_0	439481.Aboo_1085	2.44e-143	473.0	COG1243@1|root,arCOG01361@2157|Archaea,2XT9Z@28890|Euryarchaeota,3F2HC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Radical_SAM C-terminal domain	elp3	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Radical_SAM,Radical_SAM_C
SX1_k127_5688795_2	880073.Calab_0356	4.241e-32	131.0	COG0543@1|root,COG0543@2|Bacteria,2NPJH@2323|unclassified Bacteria	2|Bacteria	CH	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	pyrK	-	1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14	ko:K00266,ko:K00528,ko:K02823	ko00240,ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00240,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248,R10159	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,Fer4_20,NAD_binding_1
SX1_k127_5691924_1	517418.Ctha_1068	6.28e-11	74.0	COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria	2|Bacteria	V	DNA modification	-	-	2.1.1.72	ko:K07317	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Eco57I,N6_Mtase
SX1_k127_5691924_0	481448.Minf_1523	2.681e-27	126.0	COG1215@1|root,COG1215@2|Bacteria,46SF7@74201|Verrucomicrobia,37FYJ@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3
SX1_k127_5691924_2	335543.Sfum_1801	3.441e-08	62.0	COG0247@1|root,COG0247@2|Bacteria,1R8YC@1224|Proteobacteria,42NJW@68525|delta/epsilon subdivisions,2WIX1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
SX1_k127_5693661_8	1336243.JAEA01000005_gene1344	3.626e-07	54.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	yjaU	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Hydrolase_4
SX1_k127_5693661_7	1123075.AUDP01000027_gene664	4.632e-23	112.0	COG4927@1|root,COG4927@2|Bacteria,1UEAE@1239|Firmicutes,24NBC@186801|Clostridia	186801|Clostridia	S	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase	-	-	-	ko:K19200	ko00311,ko01100,ko01130,map00311,map01100,map01130	-	-	-	ko00000,ko00001,ko01002	-	-	-	AAT
SX1_k127_5693661_1	158190.SpiGrapes_2743	1.611e-101	348.0	COG2211@1|root,COG2211@2|Bacteria,2JAUS@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX1_k127_5693661_3	667014.Thein_1907	3.718e-64	234.0	COG0123@1|root,COG0123@2|Bacteria,2GHD6@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
SX1_k127_5693661_6	439481.Aboo_0610	1.617e-23	115.0	COG1055@1|root,arCOG00238@2157|Archaea,2XVWR@28890|Euryarchaeota,3F2QA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	P	Bacterial Na+/H+ antiporter B (NhaB)	arsB	-	-	ko:K03893	-	-	-	-	ko00000,ko02000	2.A.45.1,3.A.4.1	-	-	ArsB,CitMHS
SX1_k127_5693661_5	1304885.AUEY01000035_gene2233	8.467e-28	118.0	COG2050@1|root,COG2050@2|Bacteria	2|Bacteria	Q	thiolester hydrolase activity	-	-	-	ko:K02614	ko00360,map00360	-	R09840	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	4HBT
SX1_k127_5693661_2	386456.JQKN01000001_gene1846	5.312e-75	263.0	arCOG12964@1|root,arCOG12964@2157|Archaea,2Y2FZ@28890|Euryarchaeota	28890|Euryarchaeota	S	Tocopherol cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Tocopherol_cycl
SX1_k127_5693661_4	536227.CcarbDRAFT_2378	1.748e-31	134.0	COG0778@1|root,COG1145@1|root,COG0778@2|Bacteria,COG1145@2|Bacteria,1TPKH@1239|Firmicutes,249WN@186801|Clostridia,36FT6@31979|Clostridiaceae	186801|Clostridia	C	4Fe-4S ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Fer4_6,Nitroreductase
SX1_k127_5693661_0	411467.BACCAP_04855	3.712e-115	382.0	COG3119@1|root,COG3119@2|Bacteria,1V6NF@1239|Firmicutes,25P7A@186801|Clostridia,26BBC@186813|unclassified Clostridiales	186801|Clostridia	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
SX1_k127_5702157_2	485913.Krac_6057	5.17e-46	175.0	COG0406@1|root,COG0406@2|Bacteria	2|Bacteria	G	alpha-ribazole phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
SX1_k127_5702157_3	545697.HMPREF0216_00152	3.774e-16	90.0	COG0671@1|root,COG0671@2|Bacteria,1V01Y@1239|Firmicutes,24DFI@186801|Clostridia,36VSV@31979|Clostridiaceae	186801|Clostridia	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
SX1_k127_5702157_7	998674.ATTE01000001_gene3881	9.923e-07	55.0	COG2005@1|root,COG2005@2|Bacteria,1P9SX@1224|Proteobacteria,1SFP7@1236|Gammaproteobacteria,4618E@72273|Thiotrichales	72273|Thiotrichales	S	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	ko:K02019	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1
SX1_k127_5702157_8	1511.CLOST_2102	1.248e-06	57.0	COG2041@1|root,COG2041@2|Bacteria,1USYS@1239|Firmicutes,250DM@186801|Clostridia	186801|Clostridia	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
SX1_k127_5702157_5	1041930.Mtc_0154	1.409e-09	70.0	COG2041@1|root,arCOG00266@2157|Archaea	2157|Archaea	P	COG2041 Sulfite oxidase and related enzymes	-	-	-	ko:K16925	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.30	-	-	ABC_cobalt,Oxidored_molyb
SX1_k127_5702157_0	562981.HMPREF0428_00024	4.204e-68	250.0	COG1129@1|root,COG1129@2|Bacteria,1TQRP@1239|Firmicutes,4IS5S@91061|Bacilli,3WDWN@539002|Bacillales incertae sedis	91061|Bacilli	G	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
SX1_k127_5702157_4	1280676.AUJO01000022_gene3030	6.342e-15	85.0	COG0619@1|root,COG0619@2|Bacteria,1TPMV@1239|Firmicutes,24AYK@186801|Clostridia,4BX4Q@830|Butyrivibrio	186801|Clostridia	P	Cobalt transport protein	-	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
SX1_k127_5702157_1	579137.Metvu_1548	4.491e-47	173.0	COG0184@1|root,arCOG04185@2157|Archaea,2XWKV@28890|Euryarchaeota,23QST@183939|Methanococci	183939|Methanococci	J	ribosomal protein S15	rps15	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13_N,Ribosomal_S15
SX1_k127_5702157_6	1236689.MMALV_13650	7.668e-09	58.0	COG1890@1|root,arCOG04186@2157|Archaea,2XSX9@28890|Euryarchaeota,3F2MY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eS1 family	rps3ae	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576	-	ko:K02984	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S3Ae
SX1_k127_5706945_0	163908.KB235896_gene1783	7.958e-07	57.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1G3DB@1117|Cyanobacteria,1HU8E@1161|Nostocales	1117|Cyanobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
SX1_k127_5706945_1	1094980.Mpsy_2670	4.342e-05	47.0	arCOG07671@1|root,arCOG07671@2157|Archaea,2Y3EQ@28890|Euryarchaeota,2NAS8@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
SX1_k127_5709765_2	1095769.CAHF01000011_gene2161	1.07e-12	75.0	COG2263@1|root,COG2263@2|Bacteria,1QZDU@1224|Proteobacteria,2W0D7@28216|Betaproteobacteria,474J0@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Ribosomal protein L11 methyltransferase (PrmA)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
SX1_k127_5709765_3	927658.AJUM01000024_gene2592	2.203e-08	57.0	COG3525@1|root,COG3525@2|Bacteria,4NE08@976|Bacteroidetes,2FNAR@200643|Bacteroidia,3XJV8@558415|Marinilabiliaceae	976|Bacteroidetes	G	Glycosyl hydrolase family 20, domain 2	-	-	3.2.1.52	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	M00079	R00022,R06004,R11316	RC00049	ko00000,ko00001,ko00002,ko01000,ko03110	-	GH20	-	CHB_HEX_C_1,Fn3_assoc,Glyco_hydro_20,Glyco_hydro_20b,PA14
SX1_k127_5709765_0	1229520.ADIAL_1579	7.279e-77	265.0	arCOG06481@1|root,2ZB4E@2|Bacteria,1V0ND@1239|Firmicutes,4HFG5@91061|Bacilli,27FK3@186828|Carnobacteriaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_5709765_1	1117315.AHCA01000002_gene3418	2.724e-30	126.0	COG1252@1|root,COG1252@2|Bacteria,1RDYD@1224|Proteobacteria,1SC19@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
SX1_k127_5715868_4	416591.Tlet_0808	3.044e-55	204.0	COG1136@1|root,COG1136@2|Bacteria,2GCNV@200918|Thermotogae	200918|Thermotogae	P	PFAM ABC transporter	-	-	-	ko:K02003,ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX1_k127_5715868_3	269797.Mbar_A1789	5.822e-61	222.0	COG1234@1|root,arCOG00501@2157|Archaea,2XTJ9@28890|Euryarchaeota,2N96S@224756|Methanomicrobia	224756|Methanomicrobia	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
SX1_k127_5715868_17	1268240.ATFI01000001_gene3531	1.828e-05	57.0	COG0457@1|root,COG0457@2|Bacteria,4P8Z4@976|Bacteroidetes,2FP7A@200643|Bacteroidia,4ANUH@815|Bacteroidaceae	976|Bacteroidetes	S	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_8
SX1_k127_5715868_5	102232.GLO73106DRAFT_00012770	4.38e-55	204.0	COG1028@1|root,COG1028@2|Bacteria,1G3UI@1117|Cyanobacteria	1117|Cyanobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	1.1.1.102	ko:K04708	ko00600,ko01100,map00600,map01100	M00094,M00099	R02978	RC00089	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short
SX1_k127_5715868_11	439235.Dalk_4841	1.008e-17	88.0	2DSXM@1|root,33HUR@2|Bacteria,1NKYR@1224|Proteobacteria,430HU@68525|delta/epsilon subdivisions,2WW10@28221|Deltaproteobacteria,2MNS7@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_5715868_1	391623.TERMP_00481	2.424e-82	286.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTAH@28890|Euryarchaeota,245CI@183968|Thermococci	183968|Thermococci	O	AIR synthase related protein, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AIRS,AIRS_C
SX1_k127_5715868_7	69014.TK0876	6.42e-32	135.0	COG1756@1|root,arCOG04122@2157|Archaea,2XX9G@28890|Euryarchaeota,243H9@183968|Thermococci	183968|Thermococci	J	Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA	nep1	GO:0000154,GO:0000462,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019843,GO:0022613,GO:0030490,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070037,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363	2.1.1.260	ko:K14568	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009	-	-	-	EMG1
SX1_k127_5715868_13	351160.RCIX609	4.906e-11	69.0	COG2023@1|root,arCOG04345@2157|Archaea,2XYX0@28890|Euryarchaeota,2NA13@224756|Methanomicrobia	224756|Methanomicrobia	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp4	-	3.1.26.5	ko:K03540	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Rpr2
SX1_k127_5715868_15	694429.Pyrfu_0090	1.195e-08	59.0	COG1534@1|root,arCOG01346@2157|Archaea,2XRFX@28889|Crenarchaeota	28889|Crenarchaeota	J	CRS1_YhbY	-	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
SX1_k127_5715868_8	573063.Metin_0367	1.063e-29	123.0	COG2238@1|root,arCOG01344@2157|Archaea,2XXA6@28890|Euryarchaeota,23QVX@183939|Methanococci	183939|Methanococci	J	May be involved in maturation of the 30S ribosomal subunit	rps19e	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02966	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19e
SX1_k127_5715868_14	573063.Metin_0366	6.828e-11	67.0	COG2118@1|root,arCOG04179@2157|Archaea,2XZUR@28890|Euryarchaeota,23R6F@183939|Methanococci	183939|Methanococci	S	Belongs to the PDCD5 family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K06875	-	-	-	-	ko00000	-	-	-	dsDNA_bind
SX1_k127_5715868_19	9598.ENSPTRP00000040334	0.0008326	44.0	COG0008@1|root,KOG0002@2759|Eukaryota	2759|Eukaryota	J	structural constituent of ribosome	RPL39	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	6.1.1.18	ko:K01886,ko:K02924	ko00970,ko01100,ko03010,map00970,map01100,map03010	M00177,M00179,M00359,M00360	R03652	RC00055,RC00523	br01610,ko00000,ko00001,ko00002,ko01000,ko01007,ko03011,ko03016	-	-	-	Ribosomal_L39
SX1_k127_5715868_12	694440.JOMF01000008_gene942	1.362e-15	82.0	COG2097@1|root,arCOG04473@2157|Archaea,2XYWX@28890|Euryarchaeota,2N9YU@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eL31 family	rpl31e	-	-	ko:K02910	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31e
SX1_k127_5715868_6	671065.MetMK1DRAFT_00027440	4.634e-33	137.0	COG1976@1|root,arCOG04176@2157|Archaea,2XQJ0@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex	eif6	GO:0000460,GO:0000470,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030684,GO:0030687,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042273,GO:0043021,GO:0043023,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1902626,GO:1990904	-	ko:K03264	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009,ko03012	-	-	-	eIF-6
SX1_k127_5715868_18	647113.Metok_0088	0.0001207	47.0	COG2157@1|root,arCOG04175@2157|Archaea,2Y0R1@28890|Euryarchaeota,23R84@183939|Methanococci	183939|Methanococci	J	PFAM Ribosomal LX protein	rplX	-	-	ko:K02944	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18A
SX1_k127_5715868_16	444158.MmarC6_1203	1.736e-05	53.0	COG1730@1|root,arCOG01341@2157|Archaea,2XZ3V@28890|Euryarchaeota,23R6A@183939|Methanococci	183939|Methanococci	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016272,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032991,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K04797	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin
SX1_k127_5715868_0	186497.PF1766	7.182e-89	302.0	COG0552@1|root,arCOG01227@2157|Archaea,2XUBI@28890|Euryarchaeota,242QW@183968|Thermococci	183968|Thermococci	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
SX1_k127_5715868_9	1158318.ATXC01000001_gene81	5.626e-28	122.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,2G3JS@200783|Aquificae	200783|Aquificae	E	Prephenate dehydratase	pheA	GO:0003674,GO:0003824,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
SX1_k127_5715868_2	1304284.L21TH_0169	3.493e-63	224.0	COG0689@1|root,COG0689@2|Bacteria,1TQM3@1239|Firmicutes,25E5P@186801|Clostridia,36DSU@31979|Clostridiaceae	186801|Clostridia	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56,3.6.1.66	ko:K00989,ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03016	-	-	-	Ham1p_like,RNase_PH,RNase_PH_C
SX1_k127_5715868_10	351160.RRC522	5.984e-28	125.0	COG0433@1|root,arCOG00280@2157|Archaea,2Y7MA@28890|Euryarchaeota,2NA8T@224756|Methanomicrobia	224756|Methanomicrobia	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87,HAS-barrel
SX1_k127_5728246_2	36870.25166112	1.898e-22	111.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RN70@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EGP	Major facilitator superfamily	yajR	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
SX1_k127_5728246_0	452637.Oter_2142	1.22e-121	401.0	COG0446@1|root,COG0446@2|Bacteria	2|Bacteria	Q	pyridine nucleotide-disulphide oxidoreductase	-	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	AIF_C,Pyr_redox_2
SX1_k127_5728246_1	1379698.RBG1_1C00001G1193	3.138e-57	208.0	COG0006@1|root,COG0006@2|Bacteria,2NQIC@2323|unclassified Bacteria	2|Bacteria	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
SX1_k127_5732335_1	1047013.AQSP01000139_gene2368	8.372e-44	169.0	COG0730@1|root,COG0730@2|Bacteria,2NRZN@2323|unclassified Bacteria	2|Bacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
SX1_k127_5732335_4	593750.Metfor_0422	4.566e-09	59.0	arCOG04501@1|root,arCOG04501@2157|Archaea	2157|Archaea	S	COG2002 Regulators of stationary sporulation gene expression	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
SX1_k127_5732335_0	1121335.Clst_1990	2.608e-62	228.0	2BWJ3@1|root,2Z7IQ@2|Bacteria,1VRTV@1239|Firmicutes,24H21@186801|Clostridia	186801|Clostridia	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
SX1_k127_5732335_2	1158318.ATXC01000002_gene1596	5.02e-29	120.0	COG3743@1|root,COG3743@2|Bacteria,2G52I@200783|Aquificae	200783|Aquificae	S	Domain of unknown function (DUF4332)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4332
SX1_k127_5732335_3	526227.Mesil_1127	1.332e-22	108.0	2CAQ4@1|root,33YR3@2|Bacteria,1WMW6@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_5736976_1	575605.ACQN01000018_gene311	4.252e-10	62.0	COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,4H9QH@91061|Bacilli,3F3MY@33958|Lactobacillaceae	91061|Bacilli	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
SX1_k127_5736976_0	351160.RCIX939	3.637e-193	638.0	COG0013@1|root,arCOG01255@2157|Archaea,2XSXB@28890|Euryarchaeota,2N92P@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
SX1_k127_5740443_0	1172179.AUKV01000024_gene5703	3.128e-09	70.0	COG0577@1|root,COG0577@2|Bacteria,2GJTZ@201174|Actinobacteria	201174|Actinobacteria	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX1_k127_5745917_1	1460640.JCM19046_202	8.951e-14	78.0	COG1670@1|root,COG1670@2|Bacteria,1V1G8@1239|Firmicutes,4HH8Z@91061|Bacilli,1ZFN3@1386|Bacillus	91061|Bacilli	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
SX1_k127_5745917_0	403833.Pmob_0275	3.668e-203	644.0	COG1012@1|root,COG1012@2|Bacteria,2GCJA@200918|Thermotogae	200918|Thermotogae	C	PFAM Aldehyde dehydrogenase	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
SX1_k127_5746934_1	1128421.JAGA01000001_gene2345	1.06e-08	61.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,CARDB,CBM_3,DUF4091,HYR,Kelch_1,MAM,PA14,PKD,Peptidase_M43,Reprolysin_3
SX1_k127_5746934_0	572546.Arcpr_0441	1.125e-45	175.0	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,245UT@183980|Archaeoglobi	183980|Archaeoglobi	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019774,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
SX1_k127_5747565_1	688269.Theth_1509	9.723e-76	268.0	COG0240@1|root,COG0240@2|Bacteria,2GC3D@200918|Thermotogae	200918|Thermotogae	C	NAD NADP octopine nopaline dehydrogenase	-	-	1.5.1.28	ko:K04940	-	-	-	-	ko00000,ko01000	-	-	-	NAD_Gly3P_dh_N,Octopine_DH
SX1_k127_5747565_0	373903.Hore_09750	3.088e-148	488.0	COG2185@1|root,COG2185@2|Bacteria	2|Bacteria	I	cobalamin binding	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding
SX1_k127_5747565_2	868131.MSWAN_2030	7.628e-55	202.0	COG3640@1|root,arCOG00587@2157|Archaea,2XW7J@28890|Euryarchaeota	28890|Euryarchaeota	D	PFAM Cobyrinic acid a,c-diamide synthase	-	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
SX1_k127_5747565_4	391623.TERMP_00330	3.467e-10	72.0	arCOG01312@1|root,arCOG03256@1|root,arCOG03400@1|root,arCOG01312@2157|Archaea,arCOG03256@2157|Archaea,arCOG03400@2157|Archaea,2Y7MH@28890|Euryarchaeota,243S6@183968|Thermococci	183968|Thermococci	L	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
SX1_k127_5747565_3	342949.PNA2_1518	6.064e-26	122.0	COG1041@1|root,arCOG00047@2157|Archaea,2Y2EJ@28890|Euryarchaeota,2432J@183968|Thermococci	183968|Thermococci	L	Putative RNA methylase family UPF0020	-	-	-	-	-	-	-	-	-	-	-	-	UPF0020
SX1_k127_5750722_3	358220.C380_00115	0.0006045	51.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,2VR65@28216|Betaproteobacteria,4AB7W@80864|Comamonadaceae	28216|Betaproteobacteria	S	transferase hexapeptide	yrdA	-	-	-	-	-	-	-	-	-	-	-	Hexapep
SX1_k127_5750722_0	436114.SYO3AOP1_0476	7.128e-118	392.0	COG0065@1|root,COG0065@2|Bacteria,2G3S3@200783|Aquificae	200783|Aquificae	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
SX1_k127_5750722_1	1123372.AUIT01000001_gene675	4.416e-45	168.0	COG0066@1|root,COG0066@2|Bacteria,2GHNU@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
SX1_k127_5750722_2	243232.MJ_0778	3.229e-32	132.0	COG1418@1|root,arCOG01858@2157|Archaea,2XY7Y@28890|Euryarchaeota,23R1B@183939|Methanococci	183939|Methanococci	S	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
SX1_k127_5762169_2	7955.ENSDARP00000081514	1.397e-19	102.0	COG0476@1|root,KOG2012@2759|Eukaryota,39XR1@33154|Opisthokonta,3BMPM@33208|Metazoa,3D2CS@33213|Bilateria,48DAH@7711|Chordata,499YY@7742|Vertebrata,49UER@7898|Actinopterygii	33208|Metazoa	O	Ubiquitin-like modifier activating enzyme 7	-	-	6.2.1.45	ko:K03178	ko04120,ko05012,map04120,map05012	-	-	-	ko00000,ko00001,ko01000,ko04121,ko04147	-	-	-	E1_4HB,E1_FCCH,E1_UFD,ThiF,UBA_e1_thiolCys
SX1_k127_5762169_4	596319.STAWA0001_1439	7.059e-05	52.0	COG0546@1|root,COG0546@2|Bacteria,1V60J@1239|Firmicutes,4HI7Y@91061|Bacilli,4GZ0A@90964|Staphylococcaceae	1239|Firmicutes	S	HAD hydrolase, family IA, variant 1	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
SX1_k127_5762169_0	633148.Tagg_0732	5.415e-30	128.0	COG0071@1|root,arCOG01833@2157|Archaea,2XQD6@28889|Crenarchaeota	28889|Crenarchaeota	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
SX1_k127_5762169_3	755178.Cyan10605_2629	7.103e-07	62.0	COG0847@1|root,COG0847@2|Bacteria,1G1X6@1117|Cyanobacteria	1117|Cyanobacteria	L	'DNA polymerase III	-	-	-	-	-	-	-	-	-	-	-	-	RNase_T
SX1_k127_5762169_1	573063.Metin_0340	1.201e-25	124.0	COG1328@1|root,arCOG03714@1|root,arCOG03714@2157|Archaea,arCOG04889@2157|Archaea,2XT2S@28890|Euryarchaeota,23Q3Z@183939|Methanococci	183939|Methanococci	F	TIGRFAM anaerobic ribonucleoside-triphosphate reductase	-	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,Intein_splicing,LAGLIDADG_3,NRDD
SX1_k127_5762955_0	760568.Desku_0307	1.036e-138	460.0	COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,248ZJ@186801|Clostridia,260RA@186807|Peptococcaceae	186801|Clostridia	KL	DNA RNA helicase, superfamily II, SNF2 family	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	DUF3670,Helicase_C,SNF2_N,SWIM
SX1_k127_5762955_1	1487953.JMKF01000076_gene4052	7.902e-38	148.0	COG4279@1|root,COG4279@2|Bacteria,1G005@1117|Cyanobacteria,1H6WK@1150|Oscillatoriales	1117|Cyanobacteria	S	Swim zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
SX1_k127_5773918_1	1120985.AUMI01000016_gene1965	1.129e-203	654.0	COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,4H2D7@909932|Negativicutes	909932|Negativicutes	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
SX1_k127_5773918_0	1041930.Mtc_2238	5.307e-236	753.0	COG0188@1|root,arCOG04367@2157|Archaea,2XTZV@28890|Euryarchaeota,2N95T@224756|Methanomicrobia	224756|Methanomicrobia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
SX1_k127_577901_2	351160.LRC458	0.0001884	47.0	COG1880@1|root,arCOG04408@2157|Archaea,2XWPE@28890|Euryarchaeota,2NA4Z@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear	cdhB	-	-	ko:K00195	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00422	R07157	RC02800	ko00000,ko00001,ko00002	-	-	-	CO_dh
SX1_k127_577901_1	243232.MJ_0761	6.244e-32	135.0	COG1099@1|root,arCOG00892@2157|Archaea,2XVHW@28890|Euryarchaeota,23RE3@183939|Methanococci	183939|Methanococci	S	PFAM TatD-related deoxyribonuclease	-	-	-	ko:K07051	-	-	-	-	ko00000	-	-	-	TatD_DNase
SX1_k127_577901_0	1191523.MROS_1843	7.55e-66	233.0	COG0149@1|root,COG0149@2|Bacteria	2|Bacteria	G	triose-phosphate isomerase activity	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
SX1_k127_5796802_3	698757.Pogu_0264	2.085e-10	73.0	COG4945@1|root,arCOG03771@2157|Archaea,2XQ0I@28889|Crenarchaeota	28889|Crenarchaeota	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	Glucodextran_C,Glyco_hydro_57
SX1_k127_5796802_2	5888.CAK56845	3.521e-34	137.0	COG1100@1|root,KOG0087@2759|Eukaryota	2759|Eukaryota	J	GTPase activity	-	-	-	ko:K07904,ko:K07905,ko:K07931	ko04144,ko04152,ko04961,ko04962,ko04972,map04144,map04152,map04961,map04962,map04972	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	GCK,Ras
SX1_k127_5796802_1	374847.Kcr_1048	4.739e-49	192.0	COG0128@1|root,arCOG04134@2157|Archaea	2157|Archaea	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19,2.5.1.7	ko:K00790,ko:K00800	ko00400,ko00520,ko00550,ko01100,ko01110,ko01130,ko01230,map00400,map00520,map00550,map01100,map01110,map01130,map01230	M00022	R00660,R03460	RC00350	ko00000,ko00001,ko00002,ko01000,ko01011	-	-	-	EPSP_synthase
SX1_k127_5796802_0	1131266.ARWQ01000005_gene856	5.969e-103	346.0	COG0082@1|root,arCOG04133@2157|Archaea,41SC3@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
SX1_k127_5797450_0	1280692.AUJL01000008_gene2371	1.175e-77	280.0	COG1574@1|root,COG1574@2|Bacteria,1TQ6G@1239|Firmicutes,24A5F@186801|Clostridia,36DJ1@31979|Clostridiaceae	186801|Clostridia	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
SX1_k127_5797450_2	37659.JNLN01000001_gene2088	1.011e-23	109.0	COG3714@1|root,COG3714@2|Bacteria,1VD4D@1239|Firmicutes,24MUV@186801|Clostridia	186801|Clostridia	S	YhhN family	-	-	-	-	-	-	-	-	-	-	-	-	YhhN
SX1_k127_5797450_1	1071073.KI530538_gene349	9.284e-35	139.0	COG3393@1|root,COG3393@2|Bacteria,1V1XP@1239|Firmicutes,4HG3K@91061|Bacilli,1ZR7Q@1386|Bacillus	91061|Bacilli	S	FR47-like protein	-	-	-	ko:K06976	-	-	-	-	ko00000	-	-	-	Acetyltransf_1,FR47
SX1_k127_5802538_3	1236689.MMALV_10340	3.132e-22	103.0	COG0175@1|root,arCOG00073@2157|Archaea,2XUPU@28890|Euryarchaeota,3F2GA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Phosphoadenosine phosphosulfate reductase family	-	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0559	Fer4,Fer4_10,Fer4_7,PAPS_reduct,PUA
SX1_k127_5802538_1	1229909.NSED_09080	8.277e-63	231.0	COG1078@1|root,arCOG04430@2157|Archaea,41T0P@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
SX1_k127_5802538_2	243232.MJ_0463	2.383e-25	108.0	COG0023@1|root,arCOG04223@2157|Archaea,2XXW5@28890|Euryarchaeota,23R03@183939|Methanococci	183939|Methanococci	J	Belongs to the SUI1 family	-	GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0002190,GO:0002192,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0110017,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
SX1_k127_5802538_4	330779.Saci_0864	5.986e-09	59.0	COG1996@1|root,arCOG04341@2157|Archaea	2157|Archaea	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoP	-	2.7.7.6	ko:K03059	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	DNA_RNApol_7kD
SX1_k127_5802538_0	1006006.Mcup_0097	2.937e-81	281.0	COG1405@1|root,arCOG01981@2157|Archaea,2XQ1T@28889|Crenarchaeota	28889|Crenarchaeota	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
SX1_k127_5825247_0	72664.XP_006397650.1	7.699e-08	56.0	COG1100@1|root,KOG0393@2759|Eukaryota,37REC@33090|Viridiplantae,3GEPW@35493|Streptophyta	35493|Streptophyta	S	Belongs to the small GTPase superfamily. Rho family	-	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005737,GO:0005819,GO:0005856,GO:0005886,GO:0008150,GO:0009605,GO:0009606,GO:0009628,GO:0009629,GO:0009630,GO:0009958,GO:0009966,GO:0010646,GO:0010928,GO:0015630,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0023051,GO:0030427,GO:0031974,GO:0031981,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044422,GO:0044424,GO:0044428,GO:0044430,GO:0044446,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0070013,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K04392	ko04010,ko04013,ko04014,ko04015,ko04024,ko04062,ko04071,ko04145,ko04151,ko04310,ko04360,ko04370,ko04380,ko04510,ko04520,ko04530,ko04620,ko04650,ko04662,ko04664,ko04666,ko04670,ko04722,ko04810,ko04932,ko04933,ko04972,ko05014,ko05100,ko05120,ko05131,ko05132,ko05167,ko05200,ko05203,ko05205,ko05210,ko05211,ko05212,ko05231,ko05416,ko05418,map04010,map04013,map04014,map04015,map04024,map04062,map04071,map04145,map04151,map04310,map04360,map04370,map04380,map04510,map04520,map04530,map04620,map04650,map04662,map04664,map04666,map04670,map04722,map04810,map04932,map04933,map04972,map05014,map05100,map05120,map05131,map05132,map05167,map05200,map05203,map05205,map05210,map05211,map05212,map05231,map05416,map05418	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
SX1_k127_5827645_4	555088.DealDRAFT_2744	1.018e-34	137.0	COG0784@1|root,COG4191@1|root,COG5002@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1V0HY@1239|Firmicutes,25FZW@186801|Clostridia	186801|Clostridia	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,MEDS,Response_reg
SX1_k127_5827645_6	1128421.JAGA01000003_gene2776	1.914e-14	85.0	COG0491@1|root,COG0491@2|Bacteria,2NR8Q@2323|unclassified Bacteria	2|Bacteria	S	Metallo-beta-lactamase superfamily	fprA1	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
SX1_k127_5827645_3	368407.Memar_0832	6.449e-39	158.0	COG2144@1|root,arCOG00640@2157|Archaea,2XTU9@28890|Euryarchaeota,2N979@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM AIR synthase related protein	-	-	-	ko:K07123	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
SX1_k127_5827645_1	1392491.JIAE01000001_gene1979	7.331e-115	379.0	COG0524@1|root,COG0524@2|Bacteria,1TRRY@1239|Firmicutes,248Y3@186801|Clostridia,3WHKM@541000|Ruminococcaceae	186801|Clostridia	G	Kinase, PfkB family	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
SX1_k127_5827645_2	1203606.HMPREF1526_02991	7.089e-79	271.0	COG1028@1|root,COG1028@2|Bacteria,1V5N5@1239|Firmicutes,24AYZ@186801|Clostridia,36HJ8@31979|Clostridiaceae	186801|Clostridia	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
SX1_k127_5827645_0	243274.THEMA_02590	2.521e-159	524.0	COG1053@1|root,COG1053@2|Bacteria	2|Bacteria	C	succinate dehydrogenase	-	-	1.4.3.16,1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K00278,ko:K03388	ko00250,ko00680,ko00760,ko01100,ko01120,ko01200,map00250,map00680,map00760,map01100,map01120,map01200	M00115,M00356,M00357,M00563,M00567	R00357,R00481,R04540,R11928,R11931,R11943,R11944	RC00006,RC00011,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2
SX1_k127_5827645_5	1365176.N186_01315	3.035e-25	112.0	COG2229@1|root,arCOG00362@2157|Archaea	2157|Archaea	K	TIGRFAM Small GTP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_5827645_7	1089548.KI783301_gene228	6.558e-06	49.0	COG0476@1|root,COG0476@2|Bacteria,1UY6N@1239|Firmicutes,4HDDX@91061|Bacilli	91061|Bacilli	H	COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2	-	-	-	-	-	-	-	-	-	-	-	-	ThiF
SX1_k127_5842496_9	926561.KB900617_gene1630	0.0001063	55.0	COG0457@1|root,COG0457@2|Bacteria,1UVAY@1239|Firmicutes,25I1X@186801|Clostridia,3WBYH@53433|Halanaerobiales	186801|Clostridia	S	Anaphase-promoting complex, cyclosome, subunit 3	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2,TPR_8
SX1_k127_5842496_2	523845.AQXV01000049_gene929	9.826e-88	312.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23Q3U@183939|Methanococci	183939|Methanococci	C	heterodisulfide reductase, subunit B	hdrB2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
SX1_k127_5842496_5	1123248.KB893348_gene322	9.292e-59	208.0	COG2133@1|root,COG2133@2|Bacteria,4NF0B@976|Bacteroidetes	976|Bacteroidetes	G	glucose sorbosone	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,GSDH,Ig_2,Malectin,PKD,VCBS,fn3
SX1_k127_5842496_7	247490.KSU1_C0602	1.374e-37	145.0	COG2133@1|root,COG2133@2|Bacteria,2IXAF@203682|Planctomycetes	203682|Planctomycetes	G	glucose sorbosone	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	DUF1080,GSDH,SGL
SX1_k127_5842496_6	402880.MmarC5_0651	3.937e-40	166.0	COG1941@1|root,arCOG02472@2157|Archaea,2XV6A@28890|Euryarchaeota,23QG6@183939|Methanococci	183939|Methanococci	C	PFAM NADH ubiquinone oxidoreductase 20 kDa subunit	-	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
SX1_k127_5842496_8	264732.Moth_0439	1.958e-16	87.0	COG1150@1|root,COG1150@2|Bacteria,1V8UM@1239|Firmicutes,24J4U@186801|Clostridia,42GMS@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_8
SX1_k127_5842496_4	386456.JQKN01000001_gene1960	1.771e-67	240.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23NJW@183925|Methanobacteria	183925|Methanobacteria	C	reductase, subunit	hdrB1	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
SX1_k127_5842496_0	579137.Metvu_1488	8.903e-120	398.0	COG0374@1|root,arCOG01549@2157|Archaea,2XTHE@28890|Euryarchaeota,23QHR@183939|Methanococci	183939|Methanococci	C	PFAM Nickel-dependent hydrogenase, large subunit	vhuA	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
SX1_k127_5842496_1	591158.SSMG_04077	3.241e-114	382.0	COG2015@1|root,COG2015@2|Bacteria,2H3T3@201174|Actinobacteria	201174|Actinobacteria	Q	Alkyl sulfatase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_dimr,Lactamase_B
SX1_k127_5842496_3	1304876.AZVC01000009_gene3468	1.262e-67	236.0	COG3752@1|root,COG3752@2|Bacteria,2GNX1@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1295)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
SX1_k127_5845828_1	3218.PP1S98_21V6.1	1.393e-55	214.0	COG1287@1|root,KOG2292@2759|Eukaryota,37M0F@33090|Viridiplantae,3G8TE@35493|Streptophyta	35493|Streptophyta	O	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit	STT3B	GO:0003674,GO:0003824,GO:0004576,GO:0004579,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005886,GO:0006464,GO:0006486,GO:0006487,GO:0006807,GO:0008150,GO:0008152,GO:0008250,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0012505,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0018193,GO:0018196,GO:0018279,GO:0019538,GO:0031984,GO:0032991,GO:0034645,GO:0036211,GO:0042175,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043413,GO:0043687,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0070085,GO:0071704,GO:0071944,GO:0098796,GO:0098827,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990234	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	STT3
SX1_k127_5845828_3	351160.RCIX1698	2.074e-09	66.0	COG1719@1|root,arCOG01688@2157|Archaea,2XY7Q@28890|Euryarchaeota,2N9Q7@224756|Methanomicrobia	224756|Methanomicrobia	K	V4R	-	-	-	ko:K07013	-	-	-	-	ko00000	-	-	-	HTH_5,V4R
SX1_k127_5845828_2	1220534.B655_2084	1.133e-32	138.0	COG0101@1|root,arCOG04449@2157|Archaea,2XTH5@28890|Euryarchaeota,23NZW@183925|Methanobacteria	183925|Methanobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
SX1_k127_5845828_0	573064.Mefer_1399	4.292e-96	323.0	COG0470@1|root,arCOG00469@2157|Archaea,2XTC8@28890|Euryarchaeota,23Q6E@183939|Methanococci	183939|Methanococci	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcS	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005663,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901576	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,DNA_pol3_delta2,HTH_3,Intein_splicing,LAGLIDADG_3,Rad17,Rep_fac_C,RuvB_N
SX1_k127_5848699_1	748449.Halha_0915	6.438e-48	180.0	COG0284@1|root,COG0284@2|Bacteria,1TQ7P@1239|Firmicutes,247SZ@186801|Clostridia,3WA8V@53433|Halanaerobiales	186801|Clostridia	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS17585	OMPdecase
SX1_k127_5848699_2	1382304.JNIL01000001_gene795	6.441e-32	135.0	COG0175@1|root,COG0175@2|Bacteria,1TSMI@1239|Firmicutes,4HA9E@91061|Bacilli,277XK@186823|Alicyclobacillaceae	91061|Bacilli	EH	Belongs to the PAPS reductase family. CysH subfamily	cysH	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
SX1_k127_5848699_0	1210908.HSB1_11200	2.522e-67	238.0	COG0656@1|root,arCOG01619@2157|Archaea,2XTR0@28890|Euryarchaeota,23SRB@183963|Halobacteria	183963|Halobacteria	S	COG0656 Aldo keto reductases, related to diketogulonate reductase	-	-	1.1.1.346	ko:K06222	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
SX1_k127_5848699_4	1227457.C451_04141	9.756e-17	88.0	COG3413@1|root,arCOG02271@2157|Archaea,2XU8X@28890|Euryarchaeota,23THS@183963|Halobacteria	183963|Halobacteria	K	Bacterio-opsin activator HTH domain-containing protein	-	-	-	ko:K06930	-	-	-	-	ko00000	-	-	-	BAT,HTH_10
SX1_k127_5848699_5	279010.BL02380	6.543e-14	78.0	COG0454@1|root,COG0456@2|Bacteria,1VAU8@1239|Firmicutes,4HMA6@91061|Bacilli,1ZFP4@1386|Bacillus	91061|Bacilli	K	Acetyltransferase	yycN	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SX1_k127_5848699_3	1449126.JQKL01000002_gene1514	1.147e-22	101.0	COG2461@1|root,COG2461@2|Bacteria,1TRD5@1239|Firmicutes,24CKX@186801|Clostridia	186801|Clostridia	S	Hemerythrin HHE cation binding domain	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF1858,DUF438,Hemerythrin,PAS_10
SX1_k127_586198_1	1094980.Mpsy_3012	3.005e-63	225.0	COG3252@1|root,arCOG02675@2157|Archaea,2XUB2@28890|Euryarchaeota,2N98S@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT(	mch	-	3.5.4.27	ko:K01499	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03464	RC01870	ko00000,ko00001,ko00002,ko01000	-	-	-	MCH
SX1_k127_586198_3	1365176.N186_05870	3.417e-09	68.0	COG3389@1|root,arCOG04463@2157|Archaea,2XSEQ@28889|Crenarchaeota	28889|Crenarchaeota	S	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_586198_2	572546.Arcpr_1589	2.318e-24	114.0	COG1035@1|root,arCOG02650@2157|Archaea,2XVXF@28890|Euryarchaeota,2462X@183980|Archaeoglobi	28890|Euryarchaeota	C	PFAM Coenzyme F420 hydrogenase dehydrogenase beta subunit	-	-	1.1.98.4,1.12.98.1	ko:K00441,ko:K22174	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	Fer4_21,FrhB_FdhB_C,FrhB_FdhB_N
SX1_k127_586198_4	1396141.BATP01000057_gene3019	0.0001411	45.0	COG0454@1|root,COG0456@2|Bacteria,46W8H@74201|Verrucomicrobia,2IW5F@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_7
SX1_k127_586198_0	391623.TERMP_01136	5.288e-96	338.0	COG1199@1|root,arCOG00770@2157|Archaea,2XTH2@28890|Euryarchaeota,243PF@183968|Thermococci	183968|Thermococci	L	HELICc2	-	-	3.6.4.12	ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD_2,HBB,Helicase_C_2
SX1_k127_5894223_1	1408303.JNJJ01000070_gene2823	2.654e-18	89.0	COG1247@1|root,COG1247@2|Bacteria,1VAAC@1239|Firmicutes,4HKUR@91061|Bacilli,1ZHWJ@1386|Bacillus	91061|Bacilli	M	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,FR47
SX1_k127_5894223_0	768710.DesyoDRAFT_1775	2.288e-29	134.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K22318	-	-	-	-	ko00000	-	-	-	B12-binding,Radical_SAM
SX1_k127_5905530_1	639030.JHVA01000001_gene2705	1.033e-18	93.0	COG2120@1|root,COG2120@2|Bacteria	2|Bacteria	S	N-acetylglucosaminylinositol deacetylase activity	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
SX1_k127_5905530_0	1196323.ALKF01000194_gene1935	5.313e-38	158.0	COG2211@1|root,COG2211@2|Bacteria,1TRA5@1239|Firmicutes,4HJPK@91061|Bacilli,275UP@186822|Paenibacillaceae	91061|Bacilli	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX1_k127_5917013_8	436308.Nmar_1428	2.496e-05	49.0	COG1818@1|root,arCOG00084@2157|Archaea,41SNW@651137|Thaumarchaeota	651137|Thaumarchaeota	S	THUMP domain	-	-	-	ko:K06963	-	-	-	-	ko00000,ko03016	-	-	-	THUMP
SX1_k127_5917013_4	1229909.NSED_07825	6.819e-31	130.0	COG0009@1|root,arCOG01952@2157|Archaea,41SPF@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Sua5 YciO YrdC YwlC family	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
SX1_k127_5917013_2	933262.AXAM01000042_gene1823	3.553e-96	323.0	COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,42MQY@68525|delta/epsilon subdivisions,2WJGJ@28221|Deltaproteobacteria,2MJ2R@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
SX1_k127_5917013_0	933262.AXAM01000042_gene1824	2.718e-132	436.0	COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJG3@28221|Deltaproteobacteria,2MJ3H@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
SX1_k127_5917013_6	666510.ASAC_1055	5.523e-26	111.0	COG1144@1|root,arCOG01605@2157|Archaea,2XR7D@28889|Crenarchaeota	28889|Crenarchaeota	C	oxidoreductase, delta subunit	-	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
SX1_k127_5917013_5	933262.AXAM01000042_gene1826	7.053e-31	128.0	COG1014@1|root,COG1014@2|Bacteria,1N0EJ@1224|Proteobacteria,42UN6@68525|delta/epsilon subdivisions,2WQCE@28221|Deltaproteobacteria,2MNXX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
SX1_k127_5917013_7	573063.Metin_0532	5.732e-21	100.0	COG1779@1|root,arCOG04265@2157|Archaea,2XWNA@28890|Euryarchaeota,23QV9@183939|Methanococci	183939|Methanococci	S	ZPR1-like zinc finger protein	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K06874	-	-	-	-	ko00000	-	-	-	zf-ZPR1
SX1_k127_5917013_3	285535.JOEY01000003_gene10290	6.015e-74	263.0	COG0205@1|root,COG0205@2|Bacteria,2GK6W@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
SX1_k127_5917013_1	28532.XP_010524532.1	2.467e-116	381.0	COG5277@1|root,KOG0676@2759|Eukaryota,37I8J@33090|Viridiplantae,3G790@35493|Streptophyta,3HXTN@3699|Brassicales	35493|Streptophyta	Z	Belongs to the actin family	ACT11	GO:0003674,GO:0005198,GO:0005200,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005856,GO:0005886,GO:0005911,GO:0006996,GO:0007010,GO:0008150,GO:0009506,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009941,GO:0009987,GO:0016020,GO:0016043,GO:0030054,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0055044,GO:0071840,GO:0071944	-	ko:K10355	-	-	-	-	ko00000,ko04812	-	-	-	Actin
SX1_k127_5943601_5	1229909.NSED_06880	0.0002299	47.0	COG1310@1|root,arCOG01138@2157|Archaea,41SSV@651137|Thaumarchaeota	651137|Thaumarchaeota	S	metal-dependent protease of the PAD1 JAB1 superfamily	-	-	3.13.1.6	ko:K21140	ko04122,map04122	-	R11524	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB
SX1_k127_5943601_6	1294265.JCM21738_4725	0.0007891	51.0	COG1266@1|root,COG1266@2|Bacteria,1VEJJ@1239|Firmicutes,4IRZB@91061|Bacilli,1ZDKR@1386|Bacillus	91061|Bacilli	S	Abortive infection protein	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
SX1_k127_5943601_3	386456.JQKN01000003_gene274	1.016e-32	142.0	COG4002@1|root,arCOG00854@2157|Archaea,2XVHH@28890|Euryarchaeota,23P2F@183925|Methanobacteria	183925|Methanobacteria	S	methanogen marker protein 4	-	-	-	-	-	-	-	-	-	-	-	-	PTA_PTB
SX1_k127_5943601_4	572546.Arcpr_1339	2.998e-12	73.0	COG0200@1|root,arCOG00779@2157|Archaea,2XWM3@28890|Euryarchaeota,2471Q@183980|Archaeoglobi	183980|Archaeoglobi	J	binds to the 23S rRNA	rpl15	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
SX1_k127_5943601_2	342949.PNA2_0360	1.356e-38	149.0	COG1841@1|root,arCOG04086@2157|Archaea,2XWGP@28890|Euryarchaeota,243IZ@183968|Thermococci	183968|Thermococci	J	Ribosomal protein L30	rpl30	GO:0000463,GO:0000470,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
SX1_k127_5943601_0	933801.Ahos_0864	6.232e-67	235.0	COG0098@1|root,arCOG04087@2157|Archaea,2XPK9@28889|Crenarchaeota	28889|Crenarchaeota	J	With S4 and S12 plays an important role in translational accuracy	rps5	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
SX1_k127_5943601_1	1183377.Py04_1687	7.439e-47	174.0	COG0256@1|root,arCOG04088@2157|Archaea,2XTWT@28890|Euryarchaeota,243VI@183968|Thermococci	183968|Thermococci	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rpl18	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18_c,Ribosomal_L5e
SX1_k127_5946227_2	1121472.AQWN01000002_gene2295	1.866e-28	116.0	COG1832@1|root,COG1832@2|Bacteria,1V7C7@1239|Firmicutes,24N7A@186801|Clostridia,262C9@186807|Peptococcaceae	186801|Clostridia	S	PFAM CoA-binding domain protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
SX1_k127_5946227_4	402880.MmarC5_1359	1.441e-11	74.0	COG1014@1|root,arCOG01602@2157|Archaea,2XXU0@28890|Euryarchaeota,23R6C@183939|Methanococci	183939|Methanococci	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	-	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
SX1_k127_5946227_0	1125863.JAFN01000001_gene998	1.122e-107	374.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42N44@68525|delta/epsilon subdivisions,2WIX6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	1.2.7.8	ko:K00179,ko:K04090	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR,POR_N,TPP_enzyme_C
SX1_k127_5946227_1	416591.Tlet_0046	1.947e-40	167.0	COG2211@1|root,COG2211@2|Bacteria,2GDVW@200918|Thermotogae	200918|Thermotogae	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX1_k127_5946227_3	342949.PNA2_1206	1.21e-16	88.0	COG0681@1|root,arCOG01739@2157|Archaea,2XYEA@28890|Euryarchaeota,24456@183968|Thermococci	183968|Thermococci	U	Peptidase S24-like	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
SX1_k127_5950687_6	1121441.AUCX01000006_gene925	5.899e-17	89.0	COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,42TN9@68525|delta/epsilon subdivisions,2WRG0@28221|Deltaproteobacteria,2MCUY@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM Methylated-DNA- protein -cysteine S-methyltransferase DNA binding	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1
SX1_k127_5950687_4	123214.PERMA_0929	8.17e-49	184.0	COG0647@1|root,COG0647@2|Bacteria,2G4JV@200783|Aquificae	200783|Aquificae	G	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
SX1_k127_5950687_5	386456.JQKN01000001_gene2182	4.314e-29	132.0	COG0301@1|root,arCOG00038@2157|Archaea,2XUHM@28890|Euryarchaeota,23NP8@183925|Methanobacteria	183925|Methanobacteria	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
SX1_k127_5950687_0	1094508.Tsac_0689	1.197e-88	306.0	COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia,42FBS@68295|Thermoanaerobacterales	186801|Clostridia	JKL	PFAM DNA RNA helicase, DEAD DEAH box type, N-terminal	cshA	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
SX1_k127_5950687_3	613026.HRAG_01152	1.885e-49	185.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,42NEC@68525|delta/epsilon subdivisions,2YTQX@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	H	ThiF family	-	-	-	-	-	-	-	-	-	-	-	-	ThiF
SX1_k127_5950687_2	579137.Metvu_0771	1.061e-56	210.0	COG1184@1|root,arCOG01124@2157|Archaea,2XUFM@28890|Euryarchaeota,23REJ@183939|Methanococci	183939|Methanococci	J	Belongs to the eIF-2B alpha beta delta subunits family	-	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.29	ko:K18237	-	-	-	-	ko00000,ko01000	-	-	-	IF-2B
SX1_k127_5950687_1	693661.Arcve_0786	8.238e-69	252.0	COG1850@1|root,arCOG04443@2157|Archaea,2XVBP@28890|Euryarchaeota,245T4@183980|Archaeoglobi	183980|Archaeoglobi	G	Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase	rbcL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
SX1_k127_5950702_2	439481.Aboo_1252	5.637e-44	164.0	COG0444@1|root,arCOG00181@2157|Archaea,2XSTM@28890|Euryarchaeota,3F38V@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter	oppD2	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
SX1_k127_5950702_1	1462526.BN990_00377	6.352e-63	229.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4HBB9@91061|Bacilli,4C6EA@84406|Virgibacillus	91061|Bacilli	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1,OppC_N
SX1_k127_5950702_0	374847.Kcr_0930	2.038e-74	262.0	COG0601@1|root,arCOG00751@2157|Archaea	2157|Archaea	P	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
SX1_k127_5959294_10	472759.Nhal_3875	2.808e-05	55.0	COG2232@1|root,COG2232@2|Bacteria,1R6Y7@1224|Proteobacteria,1S781@1236|Gammaproteobacteria,1X15N@135613|Chromatiales	135613|Chromatiales	S	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3
SX1_k127_5959294_9	443254.Marpi_0639	2.831e-06	59.0	COG5276@1|root,COG5276@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,He_PIG,LVIVD,Laminin_G_3,Reprolysin_4,TSP_3
SX1_k127_5959294_1	909663.KI867150_gene284	4.289e-186	591.0	COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria,2MQ89@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Malic enzyme, NAD binding domain	maeB	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1637	Malic_M,PTA_PTB,malic
SX1_k127_5959294_8	1163730.FFONT_1180	1.61e-24	118.0	COG0644@1|root,arCOG00570@2157|Archaea,2XPWV@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM geranylgeranyl reductase	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2,FAD_binding_3,FAD_oxidored,Trp_halogenase
SX1_k127_5959294_6	592015.HMPREF1705_00366	1.243e-60	225.0	COG3875@1|root,COG3875@2|Bacteria,3TAE0@508458|Synergistetes	508458|Synergistetes	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
SX1_k127_5959294_4	401526.TcarDRAFT_2714	1.284e-89	305.0	COG0179@1|root,COG0179@2|Bacteria,1TQDQ@1239|Firmicutes,4H3E1@909932|Negativicutes	1239|Firmicutes	Q	FAH family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
SX1_k127_5959294_5	573413.Spirs_0830	5.62e-69	248.0	COG0059@1|root,COG0059@2|Bacteria,2J60P@203691|Spirochaetes	203691|Spirochaetes	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
SX1_k127_5959294_7	795797.C497_04217	1.441e-49	191.0	COG0059@1|root,arCOG04465@2157|Archaea,2XTGU@28890|Euryarchaeota,23SZC@183963|Halobacteria	2157|Archaea	E	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
SX1_k127_5959294_3	272844.PAB0045	1.743e-92	316.0	COG3191@1|root,arCOG05721@2157|Archaea,2Y2PS@28890|Euryarchaeota,243ET@183968|Thermococci	183968|Thermococci	E	Peptidase family S58	-	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
SX1_k127_5959294_2	656519.Halsa_0912	1.022e-160	520.0	COG1904@1|root,COG1904@2|Bacteria,1TRI0@1239|Firmicutes,248C0@186801|Clostridia	186801|Clostridia	G	glucuronate isomerase	uxaC	-	5.3.1.12	ko:K01812	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	UxaC
SX1_k127_5959294_0	330214.NIDE3826	0.0	1148.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,3J0XX@40117|Nitrospirae	40117|Nitrospirae	I	CoA enzyme activase uncharacterised domain (DUF2229)	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
SX1_k127_5967604_0	224325.AF_1772	7.125e-105	362.0	COG0318@1|root,arCOG00856@2157|Archaea,2XSZG@28890|Euryarchaeota,246KT@183980|Archaeoglobi	183980|Archaeoglobi	I	to SP P29212 GB L02649 GB X70994 PID 581070 GB U00096 percent identity	-	-	6.2.1.3	ko:K00666,ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
SX1_k127_5967604_1	1385514.N782_12155	5.128e-89	307.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4HC4S@91061|Bacilli,2YBWG@289201|Pontibacillus	91061|Bacilli	C	CoA-transferase family III	amacr	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
SX1_k127_5967604_2	1121468.AUBR01000090_gene747	9.456e-32	125.0	COG0183@1|root,COG0183@2|Bacteria,1TT8U@1239|Firmicutes,24AD9@186801|Clostridia	186801|Clostridia	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	DUF35_N,Thiolase_C,Thiolase_N,ketoacyl-synt
SX1_k127_6015140_0	1265505.ATUG01000002_gene2691	9.268e-187	594.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WJHC@28221|Deltaproteobacteria,2MHYJ@213118|Desulfobacterales	28221|Deltaproteobacteria	E	TIGRFAM glutamate synthase (NADPH), homotetrameric	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
SX1_k127_6015140_1	1121403.AUCV01000002_gene470	2.718e-97	349.0	COG0543@1|root,COG1034@1|root,COG3383@1|root,COG0543@2|Bacteria,COG1034@2|Bacteria,COG3383@2|Bacteria,1P8MN@1224|Proteobacteria	1224|Proteobacteria	C	NADH-quinone oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3
SX1_k127_6018502_2	933801.Ahos_0710	1.604e-18	92.0	COG1909@1|root,arCOG04076@2157|Archaea,2XRDS@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the UPF0218 family	-	-	-	ko:K09735	-	-	-	-	ko00000	-	-	-	DUF359
SX1_k127_6018502_3	246969.TAM4_736	1.084e-13	72.0	COG2093@1|root,arCOG04077@2157|Archaea,2Y0D6@28890|Euryarchaeota,244KC@183968|Thermococci	183968|Thermococci	K	Transcription elongation factor Spt4	spt4	-	2.7.7.6	ko:K03050	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Spt4
SX1_k127_6018502_0	523845.AQXV01000046_gene850	2.861e-50	186.0	COG1095@1|root,arCOG00675@2157|Archaea,2XT6U@28890|Euryarchaeota,23Q1F@183939|Methanococci	183939|Methanococci	K	RNA binding S1 domain protein	-	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03049	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	S1,SHS2_Rpb7-N
SX1_k127_6018502_1	1122243.KB903812_gene833	2.465e-31	126.0	COG2018@1|root,COG2018@2|Bacteria,1RIQC@1224|Proteobacteria,1S65Z@1236|Gammaproteobacteria,3NRCW@468|Moraxellaceae	1236|Gammaproteobacteria	S	Roadblock/LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
SX1_k127_6018502_4	1288963.ADIS_1089	3.23e-12	76.0	COG4409@1|root,COG4409@2|Bacteria,4NIJX@976|Bacteroidetes,47MH2@768503|Cytophagia	976|Bacteroidetes	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
SX1_k127_6031508_0	760011.Spico_1067	2.016e-55	209.0	COG2211@1|root,COG2211@2|Bacteria,2JAUS@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX1_k127_6031508_1	497964.CfE428DRAFT_1053	4.674e-17	86.0	COG1574@1|root,COG1574@2|Bacteria,46V0N@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
SX1_k127_6041677_0	1121441.AUCX01000018_gene1543	3.807e-33	140.0	COG0697@1|root,COG0697@2|Bacteria,1NS7A@1224|Proteobacteria,42MCJ@68525|delta/epsilon subdivisions,2WKQ4@28221|Deltaproteobacteria,2M94E@213115|Desulfovibrionales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SX1_k127_6041677_1	331113.SNE_A20910	3.23e-05	54.0	28JE3@1|root,2Z98B@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
SX1_k127_6051076_2	877415.JNJQ01000001_gene1944	2.656e-05	46.0	COG3119@1|root,COG3119@2|Bacteria,1TPWD@1239|Firmicutes,3VPJ4@526524|Erysipelotrichia	526524|Erysipelotrichia	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
SX1_k127_6051076_0	1122919.KB905617_gene161	6.878e-65	239.0	COG3119@1|root,COG3119@2|Bacteria,1UDRD@1239|Firmicutes,4HD9J@91061|Bacilli,26WKF@186822|Paenibacillaceae	91061|Bacilli	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
SX1_k127_6051076_1	474922.ELA26526	2.356e-07	53.0	28QNI@1|root,2QXBB@2759|Eukaryota,38HEQ@33154|Opisthokonta,3NWAC@4751|Fungi,3QQI7@4890|Ascomycota,2132R@147550|Sordariomycetes,1ETT3@1028384|Glomerellales	4751|Fungi	S	Bacterial alpha-L-rhamnosidase C-terminal domain	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
SX1_k127_6052755_0	523850.TON_1876	1.378e-86	311.0	COG1239@1|root,arCOG00438@2157|Archaea,2XUP4@28890|Euryarchaeota,242UB@183968|Thermococci	183968|Thermococci	H	von Willebrand factor type A domain	-	-	6.6.1.1	ko:K03404	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	Mg_chelatase,VWA_2
SX1_k127_6062389_1	485913.Krac_2085	4.147e-46	182.0	COG1835@1|root,COG1835@2|Bacteria	2|Bacteria	I	transferase activity, transferring acyl groups other than amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
SX1_k127_6062389_2	368408.Tpen_0080	8.442e-22	101.0	COG1100@1|root,arCOG06769@2157|Archaea	2157|Archaea	S	Ras of Complex, Roc, domain of DAPkinase	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	COR,LRR_4,LRR_8,Roc
SX1_k127_6062389_0	1151117.AJLF01000002_gene429	7.318e-205	648.0	COG1012@1|root,arCOG01252@2157|Archaea,2XT1Y@28890|Euryarchaeota,242S7@183968|Thermococci	183968|Thermococci	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.90	ko:K18978	ko00010,ko00030,ko01100,ko01120,ko01200,map00010,map00030,map01100,map01120,map01200	M00308,M00633	R01058,R10860	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
SX1_k127_6069533_2	420247.Msm_1583	1.55e-13	78.0	COG1202@1|root,arCOG00554@2157|Archaea,2XUCK@28890|Euryarchaeota,23NWH@183925|Methanobacteria	183925|Methanobacteria	L	PFAM DNA RNA helicase, DEAD DEAH box type, N-terminal	-	-	-	ko:K03725	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,Helicase_C
SX1_k127_6069533_1	130081.XP_005705890.1	7.008e-109	363.0	COG0162@1|root,KOG2144@2759|Eukaryota	2759|Eukaryota	J	tyrosine-tRNA ligase activity	YARS	GO:0000049,GO:0000166,GO:0001664,GO:0002181,GO:0002682,GO:0002685,GO:0002688,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004812,GO:0004831,GO:0004832,GO:0005102,GO:0005126,GO:0005153,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006437,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0006915,GO:0006935,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008219,GO:0009058,GO:0009059,GO:0009605,GO:0009966,GO:0009987,GO:0010467,GO:0010469,GO:0010494,GO:0010646,GO:0010758,GO:0012501,GO:0016070,GO:0016597,GO:0016604,GO:0016874,GO:0016875,GO:0017076,GO:0017101,GO:0017102,GO:0019538,GO:0019752,GO:0023051,GO:0030334,GO:0030545,GO:0030554,GO:0031406,GO:0031974,GO:0031981,GO:0032101,GO:0032553,GO:0032555,GO:0032559,GO:0032879,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0035770,GO:0036094,GO:0036464,GO:0040011,GO:0040012,GO:0042056,GO:0042221,GO:0042330,GO:0042379,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044421,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0045236,GO:0046483,GO:0046983,GO:0048018,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0050918,GO:0050920,GO:0051270,GO:0051716,GO:0065007,GO:0065009,GO:0070013,GO:0071704,GO:0072545,GO:0090304,GO:0097159,GO:0097367,GO:0098772,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1905521,GO:1990904,GO:2000145	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iMM904.YGR185C,iND750.YGR185C	tRNA-synt_1b,tRNA_bind
SX1_k127_6069533_0	926567.TheveDRAFT_1267	5.577e-174	563.0	COG0058@1|root,COG0058@2|Bacteria,3T9UV@508458|Synergistetes	508458|Synergistetes	G	alpha-glucan phosphorylase	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
SX1_k127_60738_0	1047013.AQSP01000134_gene1348	9.838e-179	590.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX1_k127_60738_2	761193.Runsl_2354	1.207e-17	86.0	COG1695@1|root,COG1695@2|Bacteria,4NQJP@976|Bacteroidetes,47QWB@768503|Cytophagia	976|Bacteroidetes	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
SX1_k127_60738_1	266117.Rxyl_0101	3.378e-27	113.0	COG1266@1|root,COG1266@2|Bacteria,2GMJ1@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Abortive infection protein	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
SX1_k127_6077816_0	1191523.MROS_1048	2.332e-19	102.0	COG0286@1|root,COG1002@1|root,COG0286@2|Bacteria,COG1002@2|Bacteria	2|Bacteria	V	DNA modification	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_Mtase
SX1_k127_6096280_1	7091.BGIBMGA001274-TA	3.278e-08	62.0	COG2234@1|root,KOG2195@2759|Eukaryota,38GBP@33154|Opisthokonta,3BCCZ@33208|Metazoa,3CUKC@33213|Bilateria,41XHF@6656|Arthropoda,3SKDB@50557|Insecta,445NI@7088|Lepidoptera	33208|Metazoa	OP	Peptidase family M28	-	-	-	ko:K01302	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PA,Peptidase_M28
SX1_k127_6096280_0	401526.TcarDRAFT_2684	2.409e-80	284.0	COG4277@1|root,COG4277@2|Bacteria,1TRT2@1239|Firmicutes,4H3FV@909932|Negativicutes	909932|Negativicutes	S	DNA modification repair radical SAM protein	-	-	-	-	-	-	-	-	-	-	-	-	HHH_3,Radical_SAM
SX1_k127_6121708_3	1121875.KB907547_gene3091	5.158e-11	71.0	COG0584@1|root,COG0584@2|Bacteria,4NGNU@976|Bacteroidetes,1HYHS@117743|Flavobacteriia	976|Bacteroidetes	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
SX1_k127_6121708_1	1041139.KB902702_gene2556	7.643e-23	108.0	COG1028@1|root,COG1028@2|Bacteria,1QU48@1224|Proteobacteria,2TVYV@28211|Alphaproteobacteria,4BAC1@82115|Rhizobiaceae	28211|Alphaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SX1_k127_6121708_0	374847.Kcr_1277	6.293e-86	302.0	COG2379@1|root,arCOG04170@2157|Archaea	2157|Archaea	G	Glycerate kinase	gck	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016491,GO:0016661,GO:0016662,GO:0016740,GO:0016772,GO:0043798,GO:0044237,GO:0055114	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
SX1_k127_6121708_2	688269.Theth_1040	3.855e-18	87.0	COG3450@1|root,COG3450@2|Bacteria,2GDFM@200918|Thermotogae	200918|Thermotogae	S	Enzyme of the cupin superfamily	-	-	-	ko:K06995	-	-	-	-	ko00000	-	-	-	Cupin_3
SX1_k127_6161238_0	529709.PYCH_07930	2.003e-15	88.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,243RC@183968|Thermococci	183968|Thermococci	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
SX1_k127_6192156_4	9978.XP_004598398.1	3.096e-15	82.0	COG1100@1|root,KOG0070@2759|Eukaryota,39UXZ@33154|Opisthokonta,3BKJ8@33208|Metazoa,3D0Z3@33213|Bilateria,48658@7711|Chordata,492VS@7742|Vertebrata,3J6RC@40674|Mammalia,35ERP@314146|Euarchontoglires	33208|Metazoa	U	GTP binding	ARL14	-	-	ko:K17200	-	-	-	-	ko00000,ko04031	-	-	-	Arf
SX1_k127_6192156_1	765177.Desmu_1361	1.288e-55	204.0	COG0049@1|root,arCOG04254@2157|Archaea,2XPUU@28889|Crenarchaeota	28889|Crenarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center	rps7	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
SX1_k127_6192156_0	368408.Tpen_0281	2.101e-60	211.0	COG0048@1|root,arCOG04255@2157|Archaea,2XQ79@28889|Crenarchaeota	28889|Crenarchaeota	J	With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits	rps12	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
SX1_k127_6192156_2	768672.Desfe_1466	2.458e-32	130.0	COG0195@1|root,arCOG01760@2157|Archaea,2XQDA@28889|Crenarchaeota	28889|Crenarchaeota	K	Participates in transcription termination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_2,KH_5
SX1_k127_6192156_3	933801.Ahos_0745	5.346e-16	81.0	COG1911@1|root,arCOG01752@2157|Archaea,2XR8J@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL30 family	rpl30e	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02908	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L7Ae
SX1_k127_6201608_0	1303518.CCALI_02107	1.759e-147	483.0	COG1543@1|root,COG1543@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 57 family	-	GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576	2.4.1.18	ko:K03406,ko:K16149	ko00500,ko01100,ko01110,ko02020,ko02030,map00500,map01100,map01110,map02020,map02030	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko02035	-	GH57	-	DUF1957,Glyco_hydro_57,Glyco_transf_4,Glycos_transf_1
SX1_k127_6201608_3	868131.MSWAN_0179	7.284e-47	186.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,23NW7@183925|Methanobacteria	183925|Methanobacteria	G	Belongs to the phosphohexose mutase family	glmM2	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
SX1_k127_6201608_2	768670.Calni_0991	1.476e-57	215.0	COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,2GF9F@200930|Deferribacteres	200930|Deferribacteres	GJM	Nucleotidyl transferase	-	-	2.7.7.13,5.4.2.8	ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase,PGM_PMM_I,PGM_PMM_II
SX1_k127_6201608_5	521045.Kole_1809	2.547e-10	71.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
SX1_k127_6201608_1	56110.Oscil6304_1572	9.582e-78	282.0	COG2936@1|root,COG2936@2|Bacteria	2|Bacteria	V	dipeptidyl-peptidase activity	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
SX1_k127_6201608_7	1304885.AUEY01000011_gene1744	7.15e-06	56.0	COG1309@1|root,COG1309@2|Bacteria,1N6R3@1224|Proteobacteria,42N4M@68525|delta/epsilon subdivisions,2WQ5F@28221|Deltaproteobacteria,2MKF8@213118|Desulfobacterales	28221|Deltaproteobacteria	K	WHG domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
SX1_k127_6201608_6	118173.KB235914_gene3789	8.703e-08	65.0	COG0553@1|root,COG0553@2|Bacteria,1G0S7@1117|Cyanobacteria,1H7YD@1150|Oscillatoriales	1117|Cyanobacteria	L	SNF2 family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3670,Helicase_C,SNF2_N
SX1_k127_6243529_0	1121396.KB893131_gene3668	3.656e-145	471.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,43BKD@68525|delta/epsilon subdivisions,2WJNK@28221|Deltaproteobacteria,2MIMB@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
SX1_k127_6243529_1	339860.Msp_0091	9.668e-76	263.0	COG1830@1|root,arCOG04044@2157|Archaea,2XTBQ@28890|Euryarchaeota,23NT7@183925|Methanobacteria	183925|Methanobacteria	E	Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids	aroA'	-	2.2.1.10,4.1.2.13	ko:K16306	ko00010,ko00030,ko00051,ko00400,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00400,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001	R01068,R01070,R02568,R08568	RC00438,RC00439,RC00721,RC02301	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
SX1_k127_6243529_2	1131266.ARWQ01000028_gene1021	6.666e-14	83.0	COG1404@1|root,arCOG00702@2157|Archaea,41SX3@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Belongs to the peptidase S8 family	-	-	-	ko:K14647	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	PA,Peptidase_S8
SX1_k127_6247309_1	1121335.Clst_2614	1.055e-133	438.0	COG2055@1|root,COG2055@2|Bacteria,1TR0Z@1239|Firmicutes,247W5@186801|Clostridia,3WJDT@541000|Ruminococcaceae	186801|Clostridia	C	Belongs to the LDH2 MDH2 oxidoreductase family	mdh	-	-	-	-	-	-	-	-	-	-	-	Ldh_2
SX1_k127_6247309_6	1459636.NTE_03447	0.0002515	52.0	COG0517@1|root,arCOG00601@2157|Archaea	2157|Archaea	C	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Ribosomal_S30AE
SX1_k127_6247309_5	1347368.HG964403_gene4349	6.712e-08	62.0	COG2227@1|root,COG2227@2|Bacteria,1VPPQ@1239|Firmicutes,4I0H1@91061|Bacilli	91061|Bacilli	H	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
SX1_k127_6247309_3	515620.EUBELI_01245	1.604e-41	166.0	COG0449@1|root,COG0449@2|Bacteria,1TPGU@1239|Firmicutes,248F8@186801|Clostridia,25VQ0@186806|Eubacteriaceae	186801|Clostridia	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
SX1_k127_6247309_0	1078085.HMPREF1210_02470	1.834e-142	463.0	COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,4HA2Y@91061|Bacilli,26E5Z@186818|Planococcaceae	91061|Bacilli	E	Catalyzes the interconversion of ornithine to glutamate semialdehyde	rocD	-	2.6.1.13	ko:K00819	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R00667	RC00006,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
SX1_k127_6247309_2	335543.Sfum_0047	4.974e-106	352.0	COG0549@1|root,COG0549@2|Bacteria,1MWXC@1224|Proteobacteria,42M16@68525|delta/epsilon subdivisions,2WM0V@28221|Deltaproteobacteria,2MRCH@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Amino acid kinase family	cpkA	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
SX1_k127_6247309_4	309799.DICTH_0776	9.29e-20	94.0	COG1878@1|root,COG1878@2|Bacteria	2|Bacteria	S	arylformamidase activity	-	-	1.1.1.363,1.1.1.49,3.5.1.9	ko:K00036,ko:K07130	ko00030,ko00380,ko00480,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00380,map00480,map00630,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008,M00038	R00835,R00988,R01959,R02736,R04911,R10907	RC00001,RC00066,RC00263,RC00323	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cyclase
SX1_k127_6303926_1	706587.Desti_4262	1.274e-57	209.0	COG0247@1|root,COG0247@2|Bacteria,1R8YC@1224|Proteobacteria,42NJW@68525|delta/epsilon subdivisions,2WIX1@28221|Deltaproteobacteria,2MR23@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
SX1_k127_6303926_0	1131462.DCF50_p934	3.219e-101	351.0	COG0493@1|root,COG1894@1|root,COG0493@2|Bacteria,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,260R6@186807|Peptococcaceae	186801|Clostridia	C	NADH dehydrogenase	nuoF2	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,Fer4_20,NADH_4Fe-4S,Pyr_redox_2,SLBB
SX1_k127_6303926_4	335543.Sfum_3535	7.862e-11	68.0	COG1908@1|root,COG1908@2|Bacteria,1RCZY@1224|Proteobacteria,42RJZ@68525|delta/epsilon subdivisions,2WND6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
SX1_k127_6303926_3	1122925.KB895377_gene1130	2.35e-30	124.0	COG2110@1|root,COG2110@2|Bacteria,1UI4Y@1239|Firmicutes,4HY2T@91061|Bacilli,26Y2W@186822|Paenibacillaceae	91061|Bacilli	S	phosphatase homologous to the C-terminal domain of histone macroH2A1	-	-	-	-	-	-	-	-	-	-	-	-	Macro
SX1_k127_6303926_2	1333523.L593_00570	4.526e-51	190.0	COG3119@1|root,arCOG02785@2157|Archaea,2XU7V@28890|Euryarchaeota,23T6D@183963|Halobacteria	183963|Halobacteria	P	COG3119 Arylsulfatase A and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,Sulfatase
SX1_k127_6305436_0	316274.Haur_2892	2.144e-63	228.0	COG4886@1|root,COG4886@2|Bacteria	2|Bacteria	S	regulation of response to stimulus	-	-	-	-	-	-	-	-	-	-	-	-	HtaA
SX1_k127_64592_3	1151119.KB895497_gene3394	1.839e-12	70.0	COG3752@1|root,COG3752@2|Bacteria,2GNX1@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1295)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
SX1_k127_64592_0	877455.Metbo_1534	1.138e-193	636.0	COG0474@1|root,arCOG01578@2157|Archaea,2XT4B@28890|Euryarchaeota,23PEI@183925|Methanobacteria	183925|Methanobacteria	P	ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase
SX1_k127_64592_2	867845.KI911784_gene2290	4.107e-28	123.0	COG1266@1|root,COG1266@2|Bacteria,2G7NB@200795|Chloroflexi,377D7@32061|Chloroflexia	32061|Chloroflexia	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
SX1_k127_64592_1	340099.Teth39_0204	5.088e-118	391.0	COG1453@1|root,COG1453@2|Bacteria,1TQ5N@1239|Firmicutes,247SD@186801|Clostridia,42ENG@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM aldo keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
SX1_k127_658215_3	945713.IALB_0381	8.175e-58	212.0	COG4608@1|root,COG4608@2|Bacteria	2|Bacteria	P	Belongs to the ABC transporter superfamily	dppF	-	-	ko:K02031,ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
SX1_k127_658215_2	945713.IALB_3093	1.959e-89	324.0	COG0642@1|root,COG0745@1|root,COG2202@1|root,COG2203@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria	2|Bacteria	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GGDEF,HATPase_c,HisKA,HisKA_2,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg
SX1_k127_658215_1	1191523.MROS_0930	9.559e-162	517.0	COG0787@1|root,COG0787@2|Bacteria	2|Bacteria	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
SX1_k127_658215_0	1121335.Clst_2416	5.719e-179	564.0	COG0362@1|root,COG0362@2|Bacteria,1TP4I@1239|Firmicutes,248YA@186801|Clostridia	186801|Clostridia	H	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
SX1_k127_681116_1	647113.Metok_1610	2.035e-79	274.0	COG0396@1|root,arCOG04236@2157|Archaea,2XT6T@28890|Euryarchaeota,23QIQ@183939|Methanococci	183939|Methanococci	E	PFAM ABC transporter related	-	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
SX1_k127_681116_0	523845.AQXV01000018_gene1303	1.302e-122	405.0	COG0719@1|root,arCOG01715@2157|Archaea,2XTY9@28890|Euryarchaeota,23QPC@183939|Methanococci	183939|Methanococci	O	PFAM SufBD protein	-	-	-	ko:K07033	-	-	-	-	ko00000	-	-	-	UPF0051
SX1_k127_681116_2	1449063.JMLS01000017_gene610	7.139e-11	75.0	COG3408@1|root,COG3408@2|Bacteria,1UFFT@1239|Firmicutes,4HD7Y@91061|Bacilli	91061|Bacilli	G	Trehalase	-	-	-	ko:K03931	-	-	-	-	ko00000	-	GH63	-	Trehalase
SX1_k127_690145_1	1238425.J07HQW2_03067	0.0001249	54.0	COG1310@1|root,arCOG01139@2157|Archaea,2XWKU@28890|Euryarchaeota,23VBT@183963|Halobacteria	183963|Halobacteria	S	metal-dependent protease of the PAD1 JAB1 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
SX1_k127_690145_0	1007096.BAGW01000013_gene2426	2.079e-77	264.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,2N6CX@216572|Oscillospiraceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
SX1_k127_713683_0	224719.Abm4_0046	1.851e-132	435.0	COG0269@1|root,arCOG00103@2157|Archaea,2XUYW@28890|Euryarchaeota,23NJH@183925|Methanobacteria	183925|Methanobacteria	G	Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin	fae-hps	-	4.1.2.43,4.2.1.147	ko:K13812	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05338,R08058	RC00421,RC00422,RC01583,RC01795	ko00000,ko00001,ko00002,ko01000	-	-	-	Fae,OMPdecase
SX1_k127_713683_2	314230.DSM3645_01741	7.998e-16	85.0	COG0727@1|root,COG0727@2|Bacteria,2IZM1@203682|Planctomycetes	203682|Planctomycetes	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
SX1_k127_713683_1	1304885.AUEY01000065_gene1292	1.471e-40	167.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42PFW@68525|delta/epsilon subdivisions,2WJ1N@28221|Deltaproteobacteria,2MI4U@213118|Desulfobacterales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
SX1_k127_71583_0	616991.JPOO01000001_gene3173	3.329e-47	180.0	COG2885@1|root,COG3291@1|root,COG5644@1|root,COG2885@2|Bacteria,COG3291@2|Bacteria,COG5644@2|Bacteria,4P2UU@976|Bacteroidetes,1HYAX@117743|Flavobacteriia	976|Bacteroidetes	DZ	TIGRFAM Bacterial surface protein 26-residue repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Cadherin,DUF285,TIG,TSP_3
SX1_k127_717064_0	1410609.JHVB01000001_gene1889	1.2e-44	169.0	COG0028@1|root,COG0028@2|Bacteria,2J5C9@203691|Spirochaetes	203691|Spirochaetes	EH	phosphonopyruvate decarboxylase	aepY	-	4.1.1.82	ko:K09459	ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130	-	R04053	RC00506	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_N
SX1_k127_717064_1	289377.HL41_03835	1.722e-42	179.0	COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,2GIA5@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	LV	Type II restriction enzyme, methylase subunits	-	-	-	-	-	-	-	-	-	-	-	-	Eco57I
SX1_k127_717064_2	1304885.AUEY01000042_gene3606	6.667e-31	132.0	COG0778@1|root,COG1145@1|root,COG0778@2|Bacteria,COG1145@2|Bacteria,1R42D@1224|Proteobacteria,42Q57@68525|delta/epsilon subdivisions,2WNIW@28221|Deltaproteobacteria,2MIDH@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Fer4_7,Fer4_9,Nitroreductase
SX1_k127_717064_4	195522.BD01_0427	1.177e-08	66.0	arCOG03776@1|root,arCOG03776@2157|Archaea,2Y520@28890|Euryarchaeota,243EG@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_717064_5	411474.COPEUT_01681	1.506e-07	63.0	COG1198@1|root,COG1198@2|Bacteria,1UI22@1239|Firmicutes,25EJI@186801|Clostridia	186801|Clostridia	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_717064_3	351160.RCIX132	1.644e-16	84.0	arCOG01917@1|root,arCOG01917@2157|Archaea,2XYA0@28890|Euryarchaeota	28890|Euryarchaeota	O	SPFH domain-Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DZR,zinc_ribbon_2
SX1_k127_718923_1	1444309.JAQG01000147_gene1013	1.281e-07	62.0	COG0110@1|root,COG0110@2|Bacteria,1V1SM@1239|Firmicutes,4HFTP@91061|Bacilli,26RST@186822|Paenibacillaceae	91061|Bacilli	S	Acetyltransferase	yvoF	-	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Hexapep_2
SX1_k127_718923_2	225117.XP_009374851.1	0.0003655	51.0	COG0318@1|root,KOG3628@2759|Eukaryota,37IHD@33090|Viridiplantae,3GEG9@35493|Streptophyta,4JHBB@91835|fabids	35493|Streptophyta	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Amino_oxidase,Catalase,Hexapep,NAD_binding_8,PP-binding
SX1_k127_718923_0	573061.Clocel_4117	7.011e-48	179.0	COG0266@1|root,COG0266@2|Bacteria,1TPM9@1239|Firmicutes,24BH2@186801|Clostridia,36DZN@31979|Clostridiaceae	186801|Clostridia	L	Formamidopyrimidine-DNA glycosylase H2TH domain	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
SX1_k127_720947_2	673860.AciM339_0463	5.928e-11	70.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,3F3BI@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24,HTH_5
SX1_k127_720947_1	387631.Asulf_00367	8.529e-30	132.0	COG0420@1|root,arCOG00397@2157|Archaea,2XT7A@28890|Euryarchaeota,245S5@183980|Archaeoglobi	183980|Archaeoglobi	L	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
SX1_k127_720947_0	1121381.JNIV01000075_gene2948	4.562e-61	221.0	COG0635@1|root,COG0635@2|Bacteria	2|Bacteria	H	coproporphyrinogen oxidase activity	hemN1	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
SX1_k127_736555_4	644282.Deba_2487	1.254e-07	61.0	COG2020@1|root,COG2020@2|Bacteria,1PK64@1224|Proteobacteria,432NT@68525|delta/epsilon subdivisions,2WX82@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_736555_1	639282.DEFDS_0706	1.76e-68	242.0	COG0672@1|root,COG0672@2|Bacteria,2GGKP@200930|Deferribacteres	200930|Deferribacteres	P	Iron permease FTR1 family	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1
SX1_k127_736555_3	44251.PDUR_26485	5.159e-23	110.0	COG1708@1|root,COG1708@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
SX1_k127_736555_0	748449.Halha_2502	2.225e-135	447.0	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,247W7@186801|Clostridia	186801|Clostridia	C	Belongs to the aldehyde dehydrogenase family	mmsA	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
SX1_k127_741890_4	399550.Smar_0416	3.005e-22	109.0	COG0620@1|root,arCOG01876@2157|Archaea,2XQVH@28889|Crenarchaeota	28889|Crenarchaeota	E	Catalyzes the transfer of a methyl group to L- homocysteine resulting in methionine formation. The physiological methyl donor is	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
SX1_k127_741890_1	523845.AQXV01000055_gene26	2.873e-65	231.0	COG1691@1|root,arCOG02465@2157|Archaea,2XTIH@28890|Euryarchaeota,23QAT@183939|Methanococci	183939|Methanococci	S	PFAM 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
SX1_k127_741890_6	877415.JNJQ01000011_gene674	5.917e-06	57.0	COG2120@1|root,COG2120@2|Bacteria,1TUFQ@1239|Firmicutes,3VS7E@526524|Erysipelotrichia	526524|Erysipelotrichia	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
SX1_k127_741890_3	72019.SARC_08824T0	5.156e-31	129.0	KOG0080@1|root,KOG0080@2759|Eukaryota,38EZ7@33154|Opisthokonta	33154|Opisthokonta	U	lipid droplet organization	RAB18	GO:0000166,GO:0001654,GO:0001775,GO:0001882,GO:0001883,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0005886,GO:0006810,GO:0006887,GO:0006913,GO:0006955,GO:0006996,GO:0007029,GO:0007154,GO:0007165,GO:0007264,GO:0007265,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0007423,GO:0008150,GO:0009790,GO:0009792,GO:0009987,GO:0010256,GO:0012505,GO:0012506,GO:0016020,GO:0016043,GO:0016192,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0023052,GO:0030141,GO:0030659,GO:0030667,GO:0031090,GO:0031410,GO:0031982,GO:0031984,GO:0032482,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032940,GO:0034389,GO:0035556,GO:0036094,GO:0036230,GO:0042119,GO:0042175,GO:0043009,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043299,GO:0043312,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046903,GO:0046907,GO:0048513,GO:0048731,GO:0048856,GO:0050789,GO:0050794,GO:0050896,GO:0051169,GO:0051170,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0051716,GO:0060322,GO:0065007,GO:0071782,GO:0071786,GO:0071840,GO:0071944,GO:0097159,GO:0097367,GO:0097708,GO:0098588,GO:0098805,GO:0098827,GO:0099503,GO:1901265,GO:1901363	-	ko:K07910	-	-	-	-	ko00000,ko04031,ko04131	-	-	-	Ras
SX1_k127_741890_5	1128398.Curi_c20710	6.809e-22	103.0	COG0212@1|root,COG0212@2|Bacteria,1VA91@1239|Firmicutes,24N7H@186801|Clostridia,26945@186813|unclassified Clostridiales	186801|Clostridia	H	5-formyltetrahydrofolate cyclo-ligase family	yqgN	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
SX1_k127_741890_0	459495.SPLC1_S050280	2.192e-78	272.0	COG0863@1|root,COG0863@2|Bacteria,1G4CX@1117|Cyanobacteria,1HE0Q@1150|Oscillatoriales	1117|Cyanobacteria	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
SX1_k127_741890_2	706587.Desti_5047	6.576e-54	215.0	COG0745@1|root,COG0784@1|root,COG5002@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BSJ@68525|delta/epsilon subdivisions,2X73B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
SX1_k127_741961_4	192952.MM_2884	8.461e-16	85.0	arCOG04423@1|root,arCOG04423@2157|Archaea,2XWIR@28890|Euryarchaeota,2NASM@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_741961_1	186497.PF1947	2.164e-80	279.0	COG1703@1|root,arCOG01226@2157|Archaea,2XUHG@28890|Euryarchaeota,242YC@183968|Thermococci	183968|Thermococci	E	GTPase activity	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
SX1_k127_741961_2	273068.TTE1218	1.285e-50	182.0	COG2185@1|root,COG2185@2|Bacteria,1V3QN@1239|Firmicutes,24HAR@186801|Clostridia,42GHH@68295|Thermoanaerobacterales	186801|Clostridia	I	methylmalonyl-CoA mutase C-terminal	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
SX1_k127_741961_0	760568.Desku_1207	7.524e-233	732.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,260X7@186807|Peptococcaceae	186801|Clostridia	I	TIGRFAM methylmalonyl-CoA mutase N-terminal domain	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
SX1_k127_741961_3	1219084.AP014508_gene1589	2.997e-22	101.0	COG2109@1|root,COG2109@2|Bacteria,2GCV0@200918|Thermotogae	200918|Thermotogae	H	PFAM ATP corrinoid adenosyltransferase BtuR CobO CobP	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
SX1_k127_750932_0	929703.KE386491_gene3023	1.574e-51	192.0	COG1030@1|root,COG1030@2|Bacteria,4PN0T@976|Bacteroidetes,47YFF@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TspO_MBR
SX1_k127_750932_1	443144.GM21_2336	1.413e-35	137.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,43BKD@68525|delta/epsilon subdivisions,2WJNK@28221|Deltaproteobacteria,43T3U@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
SX1_k127_756597_15	70601.3258234	3.061e-56	222.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,242QE@183968|Thermococci	183968|Thermococci	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
SX1_k127_756597_20	192952.MM_1029	2.484e-27	122.0	COG1386@1|root,arCOG02613@2157|Archaea,2XZ7Q@28890|Euryarchaeota,2N9UX@224756|Methanomicrobia	224756|Methanomicrobia	K	Segregation and condensation complex subunit ScpB	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
SX1_k127_756597_7	406327.Mevan_1482	1.22e-83	299.0	COG0343@1|root,COG1370@1|root,arCOG00989@2157|Archaea,arCOG00991@2157|Archaea,2XTFH@28890|Euryarchaeota,23QBR@183939|Methanococci	183939|Methanococci	J	Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs	tgtA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.48	ko:K18779	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PUA,TGT,TGT_C2
SX1_k127_756597_23	391623.TERMP_00572	3.244e-13	79.0	COG1936@1|root,arCOG01038@2157|Archaea,2XX2A@28890|Euryarchaeota,242QS@183968|Thermococci	183968|Thermococci	F	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates	-	-	2.7.4.3	ko:K18532	ko00230,ko01100,ko01110,ko01130,ko03008,map00230,map01100,map01110,map01130,map03008	M00049	R00127,R01547	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	AAA_18
SX1_k127_756597_21	593117.TGAM_2129	4.08e-18	94.0	COG0575@1|root,arCOG04106@2157|Archaea,2XWNR@28890|Euryarchaeota,243AW@183968|Thermococci	183968|Thermococci	I	Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids	carS	-	2.7.7.67	ko:K19664	ko00564,map00564	-	R08966	RC00002	ko00000,ko00001,ko01000	-	-	-	CarS-like
SX1_k127_756597_5	439235.Dalk_2461	1.219e-103	350.0	COG4948@1|root,COG4948@2|Bacteria,1MW5B@1224|Proteobacteria,43BF7@68525|delta/epsilon subdivisions,2X6TK@28221|Deltaproteobacteria,2MIQS@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
SX1_k127_756597_19	374847.Kcr_1471	3.261e-29	130.0	COG2304@1|root,arCOG02902@2157|Archaea	2157|Archaea	O	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA,VWA_2
SX1_k127_756597_10	374847.Kcr_1472	9.581e-71	250.0	COG0714@1|root,arCOG00441@2157|Archaea	2157|Archaea	V	ATPase associated with various cellular activities, AAA_5	gvpN	-	-	ko:K03924,ko:K04748	-	-	R00294	RC02794	ko00000,ko01000	3.D.4.10	-	-	AAA_5,CbbQ_C,HHH_5
SX1_k127_756597_0	529709.PYCH_06490	2.547e-163	543.0	COG0068@1|root,arCOG01187@2157|Archaea,2XTHZ@28890|Euryarchaeota,242XT@183968|Thermococci	183968|Thermococci	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Peptidase_M22,Sua5_yciO_yrdC,zf-HYPF
SX1_k127_756597_14	332101.JIBU02000078_gene3869	2.032e-58	210.0	COG4656@1|root,COG4656@2|Bacteria,1TS9H@1239|Firmicutes,24DQ7@186801|Clostridia,36H5R@31979|Clostridiaceae	186801|Clostridia	C	Methylene-tetrahydrofolate reductase C terminal	-	-	-	-	-	-	-	-	-	-	-	iHN637.CLJU_RS18525	MTHFR_C
SX1_k127_756597_17	237368.SCABRO_00079	3.722e-53	199.0	COG0685@1|root,COG0685@2|Bacteria,2J1PK@203682|Planctomycetes	203682|Planctomycetes	C	Methylenetetrahydrofolate reductase	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
SX1_k127_756597_16	1123242.JH636434_gene4080	1.427e-55	210.0	COG1073@1|root,COG1073@2|Bacteria,2IWT8@203682|Planctomycetes	203682|Planctomycetes	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_756597_13	557599.MKAN_03715	1.567e-62	236.0	COG0111@1|root,COG0235@1|root,COG1070@1|root,COG0111@2|Bacteria,COG0235@2|Bacteria,COG1070@2|Bacteria,2GIZV@201174|Actinobacteria,23EW1@1762|Mycobacteriaceae	201174|Actinobacteria	EGH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	1.1.1.399,1.1.1.95,2.7.1.189	ko:K00058,ko:K11216	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,ko02024,map00260,map00680,map01100,map01120,map01130,map01200,map01230,map02024	M00020	R01513,R11183	RC00002,RC00017,RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,Aldolase_II,SCP2
SX1_k127_756597_22	1232453.BAIF02000008_gene3011	1.415e-17	96.0	COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,2690R@186813|unclassified Clostridiales	186801|Clostridia	G	FGGY family of carbohydrate kinases, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FGGY_C,FGGY_N
SX1_k127_756597_18	926569.ANT_14650	1.878e-36	141.0	COG3255@1|root,COG3255@2|Bacteria,2G95B@200795|Chloroflexi	200795|Chloroflexi	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
SX1_k127_756597_6	926550.CLDAP_35830	9.792e-87	300.0	COG1454@1|root,COG1454@2|Bacteria,2G6IU@200795|Chloroflexi	200795|Chloroflexi	C	PFAM iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
SX1_k127_756597_2	224325.AF_0340	6.251e-126	424.0	COG2414@1|root,arCOG00706@2157|Archaea,2XWCH@28890|Euryarchaeota,245R8@183980|Archaeoglobi	183980|Archaeoglobi	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
SX1_k127_756597_24	608538.HTH_1202	2.482e-08	62.0	COG0454@1|root,COG0456@2|Bacteria,2G48Y@200783|Aquificae	200783|Aquificae	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
SX1_k127_756597_11	523850.TON_0652	3.036e-68	245.0	COG1537@1|root,arCOG01741@2157|Archaea,2XTQ4@28890|Euryarchaeota,243CE@183968|Thermococci	183968|Thermococci	J	May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity	pelA	GO:0000956,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006402,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0019222,GO:0019439,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0034655,GO:0034660,GO:0034661,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0070651,GO:0070966,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1901361,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903008	-	ko:K06965	ko03015,map03015	-	-	-	ko00000,ko00001	-	-	-	eRF1_1,eRF1_2,eRF1_3
SX1_k127_756597_12	589924.Ferp_1106	8.603e-63	230.0	COG2100@1|root,arCOG00951@2157|Archaea,2XU1G@28890|Euryarchaeota,245Y6@183980|Archaeoglobi	183980|Archaeoglobi	S	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K06935	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM
SX1_k127_756597_8	644281.MFS40622_0093	6.68e-76	261.0	COG0090@1|root,arCOG04067@2157|Archaea,2XTCS@28890|Euryarchaeota,23Q5Y@183939|Methanococci	183939|Methanococci	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rpl2	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
SX1_k127_756597_3	572546.Arcpr_1629	4.554e-111	370.0	COG1222@1|root,arCOG01306@2157|Archaea,2XTB6@28890|Euryarchaeota,246U9@183980|Archaeoglobi	183980|Archaeoglobi	O	ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates	pan	-	-	ko:K03420	ko03050,map03050	M00343	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA
SX1_k127_756597_1	1321778.HMPREF1982_00036	5.902e-135	445.0	COG0252@1|root,COG0252@2|Bacteria,1TPP9@1239|Firmicutes,248F3@186801|Clostridia,26881@186813|unclassified Clostridiales	186801|Clostridia	EJ	Psort location Cytoplasmic, score	-	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
SX1_k127_756597_4	644281.MFS40622_0962	2.187e-105	365.0	COG2511@1|root,arCOG01719@2157|Archaea,2XT73@28890|Euryarchaeota,23QDW@183939|Methanococci	183939|Methanococci	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GAD,GatB_N,GatB_Yqey
SX1_k127_756597_9	1321778.HMPREF1982_00036	7.024e-72	251.0	COG0252@1|root,COG0252@2|Bacteria,1TPP9@1239|Firmicutes,248F3@186801|Clostridia,26881@186813|unclassified Clostridiales	186801|Clostridia	EJ	Psort location Cytoplasmic, score	-	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
SX1_k127_798335_1	1232437.KL661978_gene3875	4.243e-44	168.0	COG1305@1|root,COG1305@2|Bacteria,1R9XR@1224|Proteobacteria,42QTZ@68525|delta/epsilon subdivisions,2WMV1@28221|Deltaproteobacteria,2MJRM@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
SX1_k127_798335_0	1122992.CBQQ010000069_gene2244	1.815e-100	345.0	COG0702@1|root,COG0702@2|Bacteria,4PMY5@976|Bacteroidetes,2G0KD@200643|Bacteroidia	976|Bacteroidetes	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	3Beta_HSD
SX1_k127_809395_0	385682.AFSL01000034_gene2986	1.976e-159	519.0	COG3250@1|root,COG3250@2|Bacteria,4NFPC@976|Bacteroidetes,2FPUZ@200643|Bacteroidia,3XJS2@558415|Marinilabiliaceae	976|Bacteroidetes	G	Glycosyl hydrolases family 2, TIM barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
SX1_k127_809395_1	1047013.AQSP01000059_gene2098	3.309e-112	371.0	COG0451@1|root,COG0451@2|Bacteria,2NQD6@2323|unclassified Bacteria	2|Bacteria	GM	RmlD substrate binding domain	ltd	-	4.2.1.45	ko:K01709	ko00520,map00520	-	R02426	RC00402	ko00000,ko00001,ko01000	-	-	-	Epimerase
SX1_k127_809395_2	326427.Cagg_0831	3.641e-39	158.0	COG0673@1|root,COG0673@2|Bacteria,2G6Y0@200795|Chloroflexi,376NR@32061|Chloroflexia	32061|Chloroflexia	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX1_k127_809917_1	443144.GM21_0585	9.288e-125	409.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,42MKX@68525|delta/epsilon subdivisions,2WJ7X@28221|Deltaproteobacteria,43UA0@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	TIGRFAM branched-chain amino acid aminotransferase	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iAF987.Gmet_2853	Aminotran_4
SX1_k127_809917_6	555079.Toce_1326	5.054e-21	97.0	COG0703@1|root,COG0757@1|root,COG0703@2|Bacteria,COG0757@2|Bacteria,1V6E8@1239|Firmicutes,24JBK@186801|Clostridia	186801|Clostridia	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
SX1_k127_809917_8	1410661.JNKW01000016_gene1131	2.043e-08	58.0	COG0169@1|root,COG0703@1|root,COG0169@2|Bacteria,COG0703@2|Bacteria,1TQRY@1239|Firmicutes,2497S@186801|Clostridia	186801|Clostridia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS14365	CM_2,SKI,Shikimate_DH,Shikimate_dh_N
SX1_k127_809917_5	573064.Mefer_1347	4.477e-55	203.0	COG0169@1|root,arCOG01033@2157|Archaea,2XV7K@28890|Euryarchaeota,23QN8@183939|Methanococci	183939|Methanococci	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	GO:0003674,GO:0003824,GO:0004764,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0055114,GO:0071704,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
SX1_k127_809917_2	243232.MJ_1326	6.957e-111	369.0	COG1163@1|root,arCOG00358@2157|Archaea,2XTYK@28890|Euryarchaeota,23QKG@183939|Methanococci	183939|Methanococci	S	TIGRFAM Small GTP-binding protein	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,MMR_HSR1_Xtn,TGS
SX1_k127_809917_7	1122128.AUEE01000002_gene1028	1.423e-17	91.0	COG0710@1|root,COG0710@2|Bacteria,1TSPN@1239|Firmicutes,4HDMG@91061|Bacilli,4H1FE@90964|Staphylococcaceae	91061|Bacilli	E	Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate	aroD	-	4.2.1.10	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I
SX1_k127_809917_0	857293.CAAU_2553	3.841e-174	557.0	COG0436@1|root,COG0436@2|Bacteria,1TRA9@1239|Firmicutes,249X4@186801|Clostridia,36GQW@31979|Clostridiaceae	186801|Clostridia	E	Alanine-glyoxylate amino-transferase	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
SX1_k127_809917_3	1158318.ATXC01000001_gene931	3.194e-100	330.0	COG0450@1|root,COG0450@2|Bacteria,2G4V9@200783|Aquificae	200783|Aquificae	O	C-terminal domain of 1-Cys peroxiredoxin	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
SX1_k127_809917_4	1408322.JHYK01000004_gene883	9.948e-64	224.0	COG0563@1|root,COG0563@2|Bacteria,1TP27@1239|Firmicutes,247YN@186801|Clostridia,27IND@186928|unclassified Lachnospiraceae	186801|Clostridia	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS20110	ADK,ADK_lid
SX1_k127_809917_9	1288494.EBAPG3_18060	1.243e-07	62.0	COG0110@1|root,COG0110@2|Bacteria,1RBYA@1224|Proteobacteria,2VRA1@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
SX1_k127_843232_1	1391646.AVSU01000056_gene1303	2.211e-53	196.0	COG1249@1|root,COG1249@2|Bacteria,1TP1W@1239|Firmicutes,249R3@186801|Clostridia,25RJ2@186804|Peptostreptococcaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
SX1_k127_843232_0	589924.Ferp_2239	1.113e-145	479.0	COG0318@1|root,arCOG00856@2157|Archaea,2XSZG@28890|Euryarchaeota,246KT@183980|Archaeoglobi	183980|Archaeoglobi	I	to SP P29212 GB L02649 GB X70994 PID 581070 GB U00096 percent identity	-	-	6.2.1.3	ko:K00666,ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
SX1_k127_843232_2	7668.SPU_020578-tr	2.627e-52	203.0	COG0584@1|root,KOG2258@2759|Eukaryota,38H8E@33154|Opisthokonta,3BBMM@33208|Metazoa,3CXUF@33213|Bilateria	33208|Metazoa	C	glycerophosphoinositol inositolphosphodiesterase activity	GDPD2	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005856,GO:0005884,GO:0005886,GO:0006996,GO:0007010,GO:0007015,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0008081,GO:0008150,GO:0008593,GO:0008889,GO:0009966,GO:0009968,GO:0009987,GO:0010646,GO:0010648,GO:0010720,GO:0012505,GO:0015629,GO:0016020,GO:0016043,GO:0016787,GO:0016788,GO:0021510,GO:0021515,GO:0021517,GO:0021522,GO:0021895,GO:0021953,GO:0022008,GO:0023051,GO:0023057,GO:0030027,GO:0030029,GO:0030030,GO:0030036,GO:0030154,GO:0030182,GO:0030278,GO:0030424,GO:0030900,GO:0031175,GO:0031252,GO:0031532,GO:0031984,GO:0032501,GO:0032502,GO:0036477,GO:0040034,GO:0042175,GO:0042578,GO:0042995,GO:0043005,GO:0043025,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0044297,GO:0044422,GO:0044424,GO:0044425,GO:0044430,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0045595,GO:0045597,GO:0045664,GO:0045666,GO:0045667,GO:0045669,GO:0045746,GO:0045778,GO:0045787,GO:0047389,GO:0048468,GO:0048471,GO:0048505,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0048666,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050767,GO:0050769,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0051239,GO:0051240,GO:0051726,GO:0051960,GO:0051962,GO:0060284,GO:0060322,GO:0065007,GO:0071840,GO:0071944,GO:0090527,GO:0097038,GO:0097435,GO:0097458,GO:0098827,GO:0099080,GO:0099081,GO:0099512,GO:0099513,GO:0120025,GO:0120036,GO:2000026	3.1.4.43	ko:K01124	-	-	-	-	ko00000,ko01000	-	-	-	GDPD
SX1_k127_843232_3	368408.Tpen_1035	8.271e-47	174.0	arCOG01917@1|root,arCOG01917@2157|Archaea,2XSQD@28889|Crenarchaeota	28889|Crenarchaeota	S	SMART zinc finger, RanBP2-type	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,UPF0547,zinc_ribbon_2
SX1_k127_849457_6	573063.Metin_0618	1.34e-17	84.0	COG2147@1|root,arCOG04089@2157|Archaea,2XWU1@28890|Euryarchaeota,23QT2@183939|Methanococci	183939|Methanococci	J	binds to the 23S rRNA	rpl19e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02885	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19e
SX1_k127_849457_5	410359.Pcal_0175	2.708e-28	119.0	COG1717@1|root,arCOG00781@2157|Archaea,2XQI2@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL32 family	rpl32e	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02912	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L32e
SX1_k127_849457_1	1163730.FFONT_0504	8.25e-51	186.0	COG0097@1|root,arCOG04090@2157|Archaea,2XQ9A@28889|Crenarchaeota	28889|Crenarchaeota	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rpl6	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
SX1_k127_849457_3	529709.PYCH_01530	5.402e-46	169.0	COG0096@1|root,arCOG04091@2157|Archaea,2XWMU@28890|Euryarchaeota,2440K@183968|Thermococci	183968|Thermococci	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rps8	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
SX1_k127_849457_7	368408.Tpen_0241	8.812e-13	69.0	COG0199@1|root,arCOG00782@2157|Archaea,2XR7G@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds 16S rRNA, required for the assembly of 30S particles	rps14	GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008270,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
SX1_k127_849457_2	765177.Desmu_1166	8.624e-47	174.0	COG0094@1|root,arCOG04092@2157|Archaea,2XQDJ@28889|Crenarchaeota	28889|Crenarchaeota	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rpl5	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
SX1_k127_849457_0	490899.DKAM_1163	1.486e-57	209.0	COG1471@1|root,arCOG04093@2157|Archaea,2XPPZ@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS4 family	rps4e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02987	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	RS4NT,Ribosomal_S4e,S4
SX1_k127_849457_8	227086.JGI_V11_46673	1.644e-12	73.0	COG0198@1|root,KOG3401@2759|Eukaryota	2759|Eukaryota	J	regulation of translation involved in cellular response to UV	RPL26	GO:0000075,GO:0000077,GO:0000184,GO:0000278,GO:0000956,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005773,GO:0005774,GO:0005829,GO:0005840,GO:0005844,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006401,GO:0006402,GO:0006412,GO:0006413,GO:0006417,GO:0006518,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006725,GO:0006807,GO:0006810,GO:0006886,GO:0006950,GO:0006974,GO:0006977,GO:0007049,GO:0007093,GO:0007154,GO:0007165,GO:0007346,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009266,GO:0009314,GO:0009409,GO:0009411,GO:0009416,GO:0009507,GO:0009536,GO:0009605,GO:0009628,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009966,GO:0009967,GO:0009987,GO:0009991,GO:0010212,GO:0010332,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010564,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010629,GO:0010646,GO:0010647,GO:0010941,GO:0010942,GO:0010948,GO:0015031,GO:0015833,GO:0015934,GO:0016020,GO:0016070,GO:0016071,GO:0016072,GO:0019222,GO:0019439,GO:0019538,GO:0022402,GO:0022613,GO:0022625,GO:0022626,GO:0023051,GO:0023052,GO:0023056,GO:0030330,GO:0030424,GO:0031090,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031570,GO:0031571,GO:0031667,GO:0031974,GO:0031981,GO:0032268,GO:0032270,GO:0032991,GO:0033036,GO:0033267,GO:0033365,GO:0033554,GO:0034248,GO:0034250,GO:0034470,GO:0034613,GO:0034641,GO:0034644,GO:0034645,GO:0034655,GO:0034660,GO:0035556,GO:0042254,GO:0042273,GO:0042594,GO:0042770,GO:0042788,GO:0042886,GO:0042981,GO:0042995,GO:0043005,GO:0043043,GO:0043065,GO:0043067,GO:0043068,GO:0043170,GO:0043195,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043516,GO:0043517,GO:0043603,GO:0043604,GO:0043679,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044271,GO:0044306,GO:0044391,GO:0044422,GO:0044424,GO:0044428,GO:0044437,GO:0044444,GO:0044445,GO:0044446,GO:0044456,GO:0044463,GO:0044464,GO:0044773,GO:0044774,GO:0044783,GO:0044819,GO:0045047,GO:0045184,GO:0045202,GO:0045727,GO:0045786,GO:0045787,GO:0045930,GO:0046483,GO:0046700,GO:0046907,GO:0048027,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051179,GO:0051234,GO:0051246,GO:0051247,GO:0051641,GO:0051649,GO:0051716,GO:0051726,GO:0060255,GO:0065007,GO:0070013,GO:0070727,GO:0070972,GO:0071156,GO:0071158,GO:0071214,GO:0071478,GO:0071479,GO:0071480,GO:0071482,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0072331,GO:0072395,GO:0072401,GO:0072413,GO:0072422,GO:0072431,GO:0072594,GO:0072599,GO:0072657,GO:0080090,GO:0080134,GO:0080135,GO:0090068,GO:0090150,GO:0090304,GO:0097159,GO:0097458,GO:0098588,GO:0098793,GO:0098805,GO:0104004,GO:0120025,GO:0120038,GO:0150034,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901796,GO:1901798,GO:1901987,GO:1901988,GO:1901990,GO:1901991,GO:1902162,GO:1902164,GO:1902165,GO:1902167,GO:1902229,GO:1902231,GO:1902253,GO:1902255,GO:1902400,GO:1902402,GO:1902403,GO:1902531,GO:1902533,GO:1902806,GO:1902807,GO:1903047,GO:1904803,GO:1990904,GO:1990928,GO:2000045,GO:2000112,GO:2000134,GO:2001020,GO:2001022,GO:2001233,GO:2001235,GO:2001242,GO:2001244	-	ko:K02898,ko:K18449,ko:K20068	ko03010,map03010	M00177	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04131	-	-	-	KOW,Ribosomal_L26
SX1_k127_849457_4	415426.Hbut_1310	8.46e-29	117.0	COG0093@1|root,arCOG04095@2157|Archaea,2XQPU@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rpl14	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
SX1_k127_849474_0	2754.EH55_13680	9.429e-07	53.0	COG2109@1|root,COG2109@2|Bacteria,3TB75@508458|Synergistetes	508458|Synergistetes	H	PFAM ATP corrinoid adenosyltransferase BtuR CobO CobP	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
SX1_k127_851303_1	272557.APE_1660.1	2.238e-11	65.0	COG1832@1|root,arCOG04227@2157|Archaea,2XQW5@28889|Crenarchaeota	28889|Crenarchaeota	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
SX1_k127_851303_3	9913.ENSBTAP00000023407	2.88e-05	53.0	KOG0078@1|root,KOG0078@2759|Eukaryota,39RSX@33154|Opisthokonta,3BJT1@33208|Metazoa,3CZUA@33213|Bilateria,486XA@7711|Chordata,491T6@7742|Vertebrata,3J5Y2@40674|Mammalia,4J54H@91561|Cetartiodactyla	33208|Metazoa	U	RAB13, member RAS oncogene family	RAB13	GO:0000003,GO:0000166,GO:0001525,GO:0001568,GO:0001667,GO:0001882,GO:0001883,GO:0001944,GO:0002064,GO:0003006,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0005911,GO:0005923,GO:0006464,GO:0006807,GO:0006810,GO:0006886,GO:0006928,GO:0006935,GO:0006996,GO:0007010,GO:0007043,GO:0007154,GO:0007165,GO:0007275,GO:0007399,GO:0007548,GO:0008104,GO:0008150,GO:0008152,GO:0008406,GO:0008584,GO:0009605,GO:0009653,GO:0009719,GO:0009725,GO:0009888,GO:0009987,GO:0010033,GO:0010243,GO:0010631,GO:0010737,GO:0010827,GO:0010828,GO:0012505,GO:0012506,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016192,GO:0016197,GO:0016328,GO:0016462,GO:0016477,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0019897,GO:0019898,GO:0019899,GO:0019900,GO:0019901,GO:0022008,GO:0022414,GO:0022607,GO:0023052,GO:0030027,GO:0030029,GO:0030030,GO:0030036,GO:0030054,GO:0030139,GO:0030141,GO:0030154,GO:0030182,GO:0030659,GO:0030855,GO:0030865,GO:0030866,GO:0031090,GO:0031175,GO:0031252,GO:0031410,GO:0031982,GO:0031984,GO:0032456,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032593,GO:0032868,GO:0032869,GO:0032870,GO:0032879,GO:0033036,GO:0033500,GO:0034236,GO:0034329,GO:0034330,GO:0034613,GO:0034762,GO:0034764,GO:0035239,GO:0035295,GO:0035556,GO:0035639,GO:0035767,GO:0036094,GO:0036211,GO:0040011,GO:0042221,GO:0042330,GO:0042592,GO:0042593,GO:0042886,GO:0042995,GO:0043005,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043296,GO:0043297,GO:0043412,GO:0043434,GO:0043542,GO:0043687,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044433,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0044795,GO:0045137,GO:0045184,GO:0045216,GO:0046324,GO:0046326,GO:0046546,GO:0046661,GO:0046907,GO:0048468,GO:0048513,GO:0048514,GO:0048518,GO:0048608,GO:0048646,GO:0048666,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0048870,GO:0048878,GO:0050789,GO:0050794,GO:0050896,GO:0051018,GO:0051049,GO:0051050,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0051674,GO:0051716,GO:0055037,GO:0060008,GO:0060009,GO:0060326,GO:0060429,GO:0061458,GO:0065007,GO:0065008,GO:0070160,GO:0070727,GO:0070830,GO:0070887,GO:0071310,GO:0071375,GO:0071417,GO:0071495,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0072358,GO:0072359,GO:0072657,GO:0072659,GO:0090130,GO:0090132,GO:0097159,GO:0097367,GO:0097368,GO:0097458,GO:0097708,GO:0098791,GO:0099503,GO:0120025,GO:0120036,GO:1901265,GO:1901363,GO:1901564,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902463,GO:1990778	-	ko:K06109	ko04530,map04530	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
SX1_k127_851303_2	33169.AAS50821	1.809e-09	69.0	COG0170@1|root,KOG2468@2759|Eukaryota,38Y7A@33154|Opisthokonta,3NUCX@4751|Fungi,3QS8S@4890|Ascomycota,3RRNS@4891|Saccharomycetes,3RYR1@4893|Saccharomycetaceae	4751|Fungi	I	to Saccharomyces cerevisiae SEC59 (YMR013C)	SEC59	GO:0003674,GO:0003824,GO:0004168,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006464,GO:0006486,GO:0006487,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0012505,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0019637,GO:0030176,GO:0031224,GO:0031227,GO:0031984,GO:0034645,GO:0036211,GO:0042175,GO:0043048,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0070085,GO:0071704,GO:0090407,GO:0098827,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	1.3.1.88,2.7.1.108	ko:K00902,ko:K05542	ko00510,ko01100,map00510,map01100	-	R01018	RC00002,RC00017	ko00000,ko00001,ko01000,ko03016	-	-	-	-
SX1_k127_851303_0	933262.AXAM01000017_gene3108	2.737e-35	143.0	COG1533@1|root,COG1533@2|Bacteria,1Q22I@1224|Proteobacteria,42SVJ@68525|delta/epsilon subdivisions,2WPAY@28221|Deltaproteobacteria,2MIXI@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Domain of unknown function (DUF1848)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1848
SX1_k127_863393_4	877421.AUJT01000008_gene2734	5.576e-09	63.0	COG1131@1|root,COG1131@2|Bacteria,1TQUS@1239|Firmicutes,25AZ1@186801|Clostridia,27I8G@186928|unclassified Lachnospiraceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX1_k127_863393_5	1236689.MMALV_14680	5.262e-08	64.0	COG1277@1|root,arCOG03689@2157|Archaea,2Y0MI@28890|Euryarchaeota,3F2VX@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
SX1_k127_863393_3	593117.TGAM_0219	6.438e-10	64.0	COG0640@1|root,arCOG01687@2157|Archaea,2Y1FZ@28890|Euryarchaeota,243EZ@183968|Thermococci	183968|Thermococci	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
SX1_k127_863393_2	439235.Dalk_2543	2.683e-65	237.0	COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,42PWI@68525|delta/epsilon subdivisions,2WKFE@28221|Deltaproteobacteria,2MKKB@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.4.1.15	ko:K05396	ko00270,map00270	-	R01874	RC00382	ko00000,ko00001,ko01000	-	-	-	PALP
SX1_k127_863393_1	882083.SacmaDRAFT_1972	2.067e-106	387.0	COG0553@1|root,COG0553@2|Bacteria,2GM2V@201174|Actinobacteria,4DXMJ@85010|Pseudonocardiales	201174|Actinobacteria	L	PFAM helicase	-	-	-	ko:K03580	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	DUF3883,Helicase_C,SNF2_N
SX1_k127_863393_0	1148.1653472	4.427e-127	427.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1G1DF@1117|Cyanobacteria,1H58Q@1142|Synechocystis	1117|Cyanobacteria	F	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
SX1_k127_882122_0	1121334.KB911067_gene52	1.847e-32	141.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia	186801|Clostridia	C	acyl-CoA dehydrogenase	-	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SX1_k127_897716_0	641107.CDLVIII_1466	1.023e-21	112.0	COG0210@1|root,COG0515@1|root,COG1112@1|root,COG0210@2|Bacteria,COG0515@2|Bacteria,COG1112@2|Bacteria,1TR8E@1239|Firmicutes,24B4D@186801|Clostridia	186801|Clostridia	L	TIGRFAM DNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12,Pkinase
SX1_k127_897716_1	688269.Theth_0016	2.727e-10	63.0	COG0171@1|root,COG0171@2|Bacteria,2GCD8@200918|Thermotogae	200918|Thermotogae	F	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE1	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
SX1_k127_952997_0	866536.Belba_3189	1.954e-23	117.0	COG0457@1|root,COG5002@1|root,COG0457@2|Bacteria,COG5002@2|Bacteria,4NI29@976|Bacteroidetes,47KZN@768503|Cytophagia	976|Bacteroidetes	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,TPR_10,TPR_12,TPR_7,TPR_8
SX1_k127_962742_5	1270193.JARP01000001_gene3122	9.656e-34	134.0	COG0451@1|root,COG0451@2|Bacteria,4NI4C@976|Bacteroidetes,1HYXU@117743|Flavobacteriia,2NYSZ@237|Flavobacterium	976|Bacteroidetes	M	Male sterility protein	-	-	-	-	-	-	-	-	-	-	-	-	3Beta_HSD,Epimerase
SX1_k127_962742_9	795797.C497_16172	2.598e-06	58.0	COG3413@1|root,arCOG02276@2157|Archaea,2XVCM@28890|Euryarchaeota,23V0F@183963|Halobacteria	183963|Halobacteria	K	DNA binding protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_10
SX1_k127_962742_3	742726.HMPREF9448_02337	5.077e-69	242.0	2DBF0@1|root,2Z8VT@2|Bacteria,4NECW@976|Bacteroidetes,2FP7Z@200643|Bacteroidia,22X94@171551|Porphyromonadaceae	976|Bacteroidetes	S	3-oxo-5-alpha-steroid 4-dehydrogenase	-	-	1.3.1.22	ko:K12343	ko00140,map00140	-	R02208,R02497,R08954,R10242	RC00145	ko00000,ko00001,ko01000	-	-	-	Steroid_dh
SX1_k127_962742_2	1434325.AZQN01000003_gene2471	6.519e-79	287.0	COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,4NFC3@976|Bacteroidetes,47MXR@768503|Cytophagia	976|Bacteroidetes	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9
SX1_k127_962742_8	1123057.P872_12445	9.827e-14	78.0	COG0745@1|root,COG0745@2|Bacteria,4NRCB@976|Bacteroidetes,47QF3@768503|Cytophagia	976|Bacteroidetes	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
SX1_k127_962742_6	391598.FBBAL38_02430	5.336e-25	109.0	COG0745@1|root,COG0745@2|Bacteria,4NRCB@976|Bacteroidetes,1I31F@117743|Flavobacteriia	976|Bacteroidetes	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
SX1_k127_962742_0	521011.Mpal_1518	3.38e-166	549.0	COG0784@1|root,arCOG02329@1|root,arCOG02329@2157|Archaea,arCOG02386@2157|Archaea,arCOG02391@2157|Archaea,2XVQ7@28890|Euryarchaeota	2157|Archaea	T	ATP-binding region, ATPase domain protein	-	-	-	ko:K03413,ko:K07662,ko:K07667	ko01503,ko02020,ko02024,ko02030,map01503,map02020,map02024,map02030	M00447,M00454,M00506,M00727,M00728	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	BAT,GAF_2,HATPase_c,HTH_10,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
SX1_k127_962742_1	1209989.TepiRe1_1681	6.017e-89	305.0	COG2008@1|root,COG2008@2|Bacteria,1TPZI@1239|Firmicutes,25J0X@186801|Clostridia,42F6Z@68295|Thermoanaerobacterales	186801|Clostridia	E	aromatic amino acid beta-eliminating lyase threonine aldolase	ltaA	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
SX1_k127_962742_4	304371.MCP_0389	4.028e-56	211.0	arCOG11014@1|root,arCOG11014@2157|Archaea,2XZ0A@28890|Euryarchaeota	2157|Archaea	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
SX1_k127_962742_7	1317122.ATO12_02325	9.039e-14	80.0	COG4335@1|root,COG4335@2|Bacteria,4NH5H@976|Bacteroidetes,1HZZW@117743|Flavobacteriia,2YH3C@290174|Aquimarina	976|Bacteroidetes	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
SX1_k127_96381_1	647113.Metok_0125	1.555e-45	173.0	COG2122@1|root,arCOG04376@2157|Archaea,2XV48@28890|Euryarchaeota,23QEX@183939|Methanococci	183939|Methanococci	S	Belongs to the UPF0280 family	-	-	-	ko:K09740	-	-	-	-	ko00000	-	-	-	-
SX1_k127_96381_0	926569.ANT_05220	1.447e-175	565.0	COG0405@1|root,COG0405@2|Bacteria,2G5R2@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
SX1_k127_96381_2	1303518.CCALI_01065	1.046e-33	141.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SX1_k127_96381_3	439235.Dalk_3108	2.422e-10	65.0	COG0778@1|root,COG0778@2|Bacteria,1Q0G9@1224|Proteobacteria,43BDR@68525|delta/epsilon subdivisions,2X6SB@28221|Deltaproteobacteria,2MPIC@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM SagB-type dehydrogenase domain	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SX1_k127_974395_0	573064.Mefer_0203	1.209e-263	832.0	COG1152@1|root,arCOG02428@2157|Archaea,2XTBY@28890|Euryarchaeota,23Q9D@183939|Methanococci	183939|Methanococci	C	Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase	cdhA	GO:0000302,GO:0003674,GO:0003824,GO:0004601,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016661,GO:0016684,GO:0042221,GO:0042493,GO:0042542,GO:0046677,GO:0050418,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748	1.2.7.4	ko:K00192	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00422	R07157	RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_7,Fer4_9,Prismane
SX1_k127_974395_1	1094980.Mpsy_2820	4.708e-05	49.0	arCOG02716@1|root,arCOG02716@2157|Archaea,2Y57Q@28890|Euryarchaeota,2NBDW@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX1_k127_988432_2	1499967.BAYZ01000171_gene5564	0.0009163	43.0	COG1150@1|root,COG1150@2|Bacteria,2NQ2K@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	dld	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390,ko:K18930	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_7,Fer4_8
SX1_k127_988432_1	429009.Adeg_2015	2.75e-43	181.0	COG1908@1|root,COG1908@2|Bacteria,1V7I6@1239|Firmicutes,24JV2@186801|Clostridia,42GG4@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD,NADH_4Fe-4S
SX1_k127_988432_0	429009.Adeg_1885	6.774e-160	532.0	COG1148@1|root,COG1148@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia,42FJG@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S ferredoxin, iron-sulfur binding	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Pyr_redox_2
## 2266 queries scanned
## Total time (seconds): 90.98902344703674
## Rate: 24.90 q/s