## Fri Nov 15 03:48:19 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin24/SX_2_bin.14.fa -m mmseqs --itype genome -o SX_2_bin.14 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/SX_2_bin.14 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
SX2_k127_1002597_1	1499967.BAYZ01000050_gene2837	1.33e-82	285.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	iolE	-	4.2.1.44	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R02782,R05659	RC00782,RC01448	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
SX2_k127_1002597_3	660470.Theba_0067	5.109e-65	246.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
SX2_k127_1002597_2	1185876.BN8_01040	4.862e-77	275.0	COG2234@1|root,COG2234@2|Bacteria,4NE5C@976|Bacteroidetes,47NIR@768503|Cytophagia	976|Bacteroidetes	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
SX2_k127_1002597_5	221027.JO40_10010	3.378e-24	119.0	COG1011@1|root,COG1011@2|Bacteria,2J9H4@203691|Spirochaetes	203691|Spirochaetes	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
SX2_k127_1002597_0	1123274.KB899423_gene1585	1.655e-151	496.0	COG1066@1|root,COG1066@2|Bacteria,2J5WN@203691|Spirochaetes	203691|Spirochaetes	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	ATPase,ChlI,Lon_C
SX2_k127_1002597_4	889378.Spiaf_0099	2.246e-34	145.0	COG1538@1|root,COG1538@2|Bacteria,2J914@203691|Spirochaetes	203691|Spirochaetes	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
SX2_k127_100509_4	1382306.JNIM01000001_gene1302	2.068e-14	82.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	ttgR	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
SX2_k127_100509_3	748727.CLJU_c26420	5.569e-16	91.0	COG2836@1|root,COG2836@2|Bacteria,1VXKF@1239|Firmicutes,24ERT@186801|Clostridia,36HRG@31979|Clostridiaceae	186801|Clostridia	S	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD_2
SX2_k127_100509_0	332101.JIBU02000025_gene3209	2.752e-107	364.0	COG0348@1|root,COG0348@2|Bacteria,1VVUA@1239|Firmicutes,24C27@186801|Clostridia,36FBA@31979|Clostridiaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Fer4_5
SX2_k127_100509_5	748727.CLJU_c26440	3.297e-07	63.0	28V20@1|root,2ZH5G@2|Bacteria,1UFNF@1239|Firmicutes,24HU4@186801|Clostridia,36JAD@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_100509_1	1047013.AQSP01000076_gene1472	1.324e-68	252.0	COG1262@1|root,COG1262@2|Bacteria,2NPU7@2323|unclassified Bacteria	2|Bacteria	G	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
SX2_k127_100509_2	234267.Acid_3515	2.232e-62	218.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
SX2_k127_1006984_3	1196323.ALKF01000161_gene792	4.339e-12	79.0	COG0519@1|root,COG0519@2|Bacteria,1TPG8@1239|Firmicutes,4HA7Q@91061|Bacilli,26SIZ@186822|Paenibacillaceae	91061|Bacilli	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
SX2_k127_1006984_1	1307761.L21SP2_1843	3.45e-164	526.0	COG0104@1|root,COG0104@2|Bacteria,2J6B6@203691|Spirochaetes	203691|Spirochaetes	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
SX2_k127_1006984_0	1123274.KB899424_gene3019	7.904e-172	554.0	COG0015@1|root,COG0015@2|Bacteria,2J60J@203691|Spirochaetes	203691|Spirochaetes	F	Adenylosuccinate lyase	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,ASL_C,Lyase_1
SX2_k127_1006984_2	1370122.JHXQ01000001_gene405	4.521e-24	111.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,4B8B4@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
SX2_k127_1029000_2	309798.COPRO5265_0007	6.479e-10	63.0	COG1328@1|root,COG1328@2|Bacteria,1TR9K@1239|Firmicutes,247WF@186801|Clostridia,42ET1@68295|Thermoanaerobacterales	186801|Clostridia	F	TIGRFAM anaerobic ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,Glutaredoxin,NRDD
SX2_k127_1029000_0	889378.Spiaf_2870	1.478e-105	349.0	COG1192@1|root,COG1192@2|Bacteria,2J5VP@203691|Spirochaetes	203691|Spirochaetes	D	CobQ CobB MinD ParA nucleotide binding domain	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
SX2_k127_1029000_1	907348.TresaDRAFT_0826	8.06e-74	262.0	COG1475@1|root,COG1475@2|Bacteria,2J5S6@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the ParB family	spo0J	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
SX2_k127_1035199_0	509191.AEDB02000076_gene1447	1.37e-71	248.0	COG2303@1|root,COG2303@2|Bacteria,1V115@1239|Firmicutes,24FDE@186801|Clostridia	186801|Clostridia	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
SX2_k127_1035199_1	1382306.JNIM01000001_gene2161	1.068e-37	164.0	COG1228@1|root,COG1228@2|Bacteria,2G96C@200795|Chloroflexi	200795|Chloroflexi	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
SX2_k127_1035199_2	889378.Spiaf_0517	1.715e-20	108.0	COG4775@1|root,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag
SX2_k127_1038795_0	744872.Spica_1006	6.549e-48	197.0	2C0A1@1|root,33WBM@2|Bacteria,2J8WC@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1038795_1	665571.STHERM_c01070	1.265e-31	128.0	COG2114@1|root,COG2114@2|Bacteria,2J6Q9@203691|Spirochaetes	203691|Spirochaetes	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP,Response_reg
SX2_k127_1045415_2	1033806.HTIA_1044	1.153e-17	88.0	COG3534@1|root,arCOG10185@2157|Archaea,2XUX4@28890|Euryarchaeota,23TE1@183963|Halobacteria	183963|Halobacteria	G	COG3534 Alpha-L-arabinofuranosidase	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
SX2_k127_1045415_0	861299.J421_6202	2.239e-140	453.0	COG1064@1|root,COG1064@2|Bacteria,1ZSXS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Zinc-binding dehydrogenase	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
SX2_k127_1045415_3	1156844.KB891798_gene6183	1.873e-11	75.0	2DBAX@1|root,2Z84Q@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2877)	yahE	-	-	-	-	-	-	-	-	-	-	-	DUF2877
SX2_k127_1045415_1	1238182.C882_4073	2.563e-45	169.0	COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,2UPJ8@28211|Alphaproteobacteria,2JQRR@204441|Rhodospirillales	204441|Rhodospirillales	S	transport systems, ATPase components	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
SX2_k127_1049043_0	1123008.KB905694_gene1688	3.248e-97	340.0	COG0210@1|root,COG1379@1|root,COG0210@2|Bacteria,COG1379@2|Bacteria,4NDWN@976|Bacteroidetes,2FNIM@200643|Bacteroidia,22WFT@171551|Porphyromonadaceae	976|Bacteroidetes	L	DNA helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
SX2_k127_1087031_1	1123376.AUIU01000012_gene1396	1.066e-73	269.0	COG1074@1|root,COG1074@2|Bacteria,3J16M@40117|Nitrospirae	40117|Nitrospirae	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
SX2_k127_1087031_0	1123376.AUIU01000012_gene1395	1.454e-83	313.0	COG2887@1|root,COG2887@2|Bacteria	2|Bacteria	L	Belongs to the helicase family. UvrD subfamily	-	-	-	-	-	-	-	-	-	-	-	-	AAA_24,PDDEXK_1
SX2_k127_1097294_0	861299.J421_5839	4.649e-35	152.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
SX2_k127_1097294_2	880073.Calab_2081	1.747e-06	61.0	COG3291@1|root,COG5276@1|root,COG3291@2|Bacteria,COG5276@2|Bacteria,2NQ2P@2323|unclassified Bacteria	2|Bacteria	P	LVIVD repeat	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	LVIVD
SX2_k127_1097294_1	1231057.AMGD01000104_gene265	6.681e-09	57.0	2EHF3@1|root,33B70@2|Bacteria,1VP4D@1239|Firmicutes,4HZXQ@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_110112_9	158190.SpiGrapes_1801	2.303e-21	96.0	COG0395@1|root,COG0395@2|Bacteria,2JA26@203691|Spirochaetes	203691|Spirochaetes	P	Binding-protein-dependent transport system inner membrane	-	-	-	ko:K17320	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
SX2_k127_110112_6	324057.Pjdr2_0746	1.038e-58	224.0	COG1653@1|root,COG1653@2|Bacteria,1UNAN@1239|Firmicutes,4HT4T@91061|Bacilli,26U4B@186822|Paenibacillaceae	91061|Bacilli	G	extracellular solute-binding protein, family 1	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_8
SX2_k127_110112_4	1499967.BAYZ01000095_gene4189	1.377e-72	254.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	uxuA	-	4.2.1.8	ko:K01686,ko:K07045	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	AIPR,Amidohydro_2
SX2_k127_110112_2	1163408.UU9_00170	8.609e-93	322.0	2DUQS@1|root,33RT2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_110112_7	1232443.BAIA02000107_gene3094	4.234e-58	223.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia,26ADQ@186813|unclassified Clostridiales	186801|Clostridia	T	Psort location Cytoplasmic, score 9.97	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,HTH_AraC,Response_reg
SX2_k127_110112_5	717605.Theco_0058	2.787e-59	235.0	COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,4HC80@91061|Bacilli,26R3T@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,His_kinase,dCache_1
SX2_k127_110112_0	1267535.KB906767_gene5008	1.064e-132	474.0	COG4447@1|root,COG4447@2|Bacteria,3Y2MX@57723|Acidobacteria,2JMA6@204432|Acidobacteriia	204432|Acidobacteriia	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_110112_8	324057.Pjdr2_0746	4.093e-36	156.0	COG1653@1|root,COG1653@2|Bacteria,1UNAN@1239|Firmicutes,4HT4T@91061|Bacilli,26U4B@186822|Paenibacillaceae	91061|Bacilli	G	extracellular solute-binding protein, family 1	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_8
SX2_k127_110112_3	439235.Dalk_5096	1.056e-75	260.0	COG0138@1|root,COG0138@2|Bacteria,1N2UC@1224|Proteobacteria,42NFS@68525|delta/epsilon subdivisions,2X5JJ@28221|Deltaproteobacteria,2MIV7@213118|Desulfobacterales	28221|Deltaproteobacteria	F	MGS-like domain	-	-	-	-	-	-	-	-	-	-	-	-	AICARFT_IMPCHas,MGS
SX2_k127_110112_1	96561.Dole_1516	3.036e-96	335.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,42MV4@68525|delta/epsilon subdivisions,2WKHZ@28221|Deltaproteobacteria,2MI2I@213118|Desulfobacterales	28221|Deltaproteobacteria	F	PFAM AICARFT IMPCHase bienzyme	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
SX2_k127_1102988_11	545694.TREPR_0086	2.783e-09	60.0	COG1176@1|root,COG1176@2|Bacteria	2|Bacteria	P	putrescine transport	Z012_03375	-	-	ko:K02054	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
SX2_k127_1102988_4	545694.TREPR_0085	5.436e-104	356.0	COG3842@1|root,COG3842@2|Bacteria,2J7DW@203691|Spirochaetes	203691|Spirochaetes	P	ABC transporter	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
SX2_k127_1102988_12	338966.Ppro_1745	6.891e-07	57.0	COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,42V9M@68525|delta/epsilon subdivisions,2WRDW@28221|Deltaproteobacteria,43SPX@69541|Desulfuromonadales	28221|Deltaproteobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
SX2_k127_1102988_2	1304880.JAGB01000002_gene1641	2.555e-166	539.0	COG2723@1|root,COG2723@2|Bacteria,1TP19@1239|Firmicutes,2485V@186801|Clostridia	186801|Clostridia	G	Belongs to the glycosyl hydrolase 1 family	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
SX2_k127_1102988_0	744872.Spica_1913	8.47e-296	956.0	COG3250@1|root,COG3250@2|Bacteria,2J5QC@203691|Spirochaetes	203691|Spirochaetes	G	family 2, TIM barrel	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
SX2_k127_1102988_6	744872.Spica_0727	1.762e-100	348.0	COG0395@1|root,COG0395@2|Bacteria,2J65P@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026,ko:K10190	ko02010,map02010	M00199,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.4	-	-	BPD_transp_1
SX2_k127_1102988_3	744872.Spica_0726	1.738e-125	409.0	COG1175@1|root,COG1175@2|Bacteria,2J5N6@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10189	ko02010,map02010	M00199	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.4	-	-	BPD_transp_1
SX2_k127_1102988_1	744872.Spica_0725	3.774e-167	548.0	COG1653@1|root,COG1653@2|Bacteria,2J5ZH@203691|Spirochaetes	203691|Spirochaetes	G	solute-binding protein	-	-	-	ko:K10188	ko02010,map02010	M00199	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.4	-	-	SBP_bac_8
SX2_k127_1102988_8	889378.Spiaf_0950	6.847e-87	292.0	COG2197@1|root,COG2197@2|Bacteria,2J7CS@203691|Spirochaetes	203691|Spirochaetes	K	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
SX2_k127_1102988_9	1480694.DC28_12230	1.785e-67	256.0	COG4585@1|root,COG4585@2|Bacteria,2J7E5@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
SX2_k127_1102988_10	1033743.CAES01000011_gene4431	4.14e-35	155.0	COG2207@1|root,COG2207@2|Bacteria,1V029@1239|Firmicutes,4HE2K@91061|Bacilli,26QS8@186822|Paenibacillaceae	91061|Bacilli	K	PFAM helix-turn-helix- domain containing protein AraC type	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,dCache_1
SX2_k127_1102988_5	1423321.AS29_12500	5.552e-103	346.0	COG4209@1|root,COG4209@2|Bacteria,1TP33@1239|Firmicutes,4HATZ@91061|Bacilli,1ZAQ3@1386|Bacillus	91061|Bacilli	G	COG4209 ABC-type polysaccharide transport system, permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
SX2_k127_1102988_7	1423321.AS29_12495	1.16e-88	301.0	COG0395@1|root,COG0395@2|Bacteria,1TQ9F@1239|Firmicutes,4HBG3@91061|Bacilli,1ZCUS@1386|Bacillus	91061|Bacilli	G	COG0395 ABC-type sugar transport system, permease component	-	-	-	ko:K17320	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
SX2_k127_1123914_1	349161.Dred_1552	1.009e-17	87.0	COG3322@1|root,COG3437@1|root,COG3829@1|root,COG3322@2|Bacteria,COG3437@2|Bacteria,COG3829@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia,260QX@186807|Peptococcaceae	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,GGDEF,HD,HD_5,PAS,PAS_4,PAS_9
SX2_k127_1123914_0	744872.Spica_2840	1.476e-166	532.0	COG1523@1|root,COG1523@2|Bacteria,2J61K@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
SX2_k127_1135814_9	1479238.JQMZ01000001_gene1278	1.25e-11	68.0	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,2TV7G@28211|Alphaproteobacteria,43XP4@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Phosphoribosyl transferase domain	comF	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
SX2_k127_1135814_7	545695.TREAZ_0547	2.697e-24	109.0	COG0779@1|root,COG0779@2|Bacteria,2J87E@203691|Spirochaetes	203691|Spirochaetes	J	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
SX2_k127_1135814_2	545694.TREPR_1755	3.08e-195	623.0	COG0195@1|root,COG0195@2|Bacteria,2J624@203691|Spirochaetes	203691|Spirochaetes	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1,zf-ribbon_3
SX2_k127_1135814_1	573413.Spirs_2028	4.792e-257	842.0	COG0532@1|root,COG0532@2|Bacteria,2J692@203691|Spirochaetes	203691|Spirochaetes	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
SX2_k127_1135814_8	906968.Trebr_1969	2.131e-20	96.0	COG0858@1|root,COG0858@2|Bacteria,2J82W@203691|Spirochaetes	203691|Spirochaetes	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
SX2_k127_1135814_3	665571.STHERM_c11160	8.225e-69	248.0	COG0130@1|root,COG0130@2|Bacteria,2J7Q2@203691|Spirochaetes	203691|Spirochaetes	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C_2,TruB_N
SX2_k127_1135814_6	243164.DET0602	5.601e-26	118.0	COG0196@1|root,COG0196@2|Bacteria,2G6JF@200795|Chloroflexi,34D5G@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Riboflavin kinase	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
SX2_k127_1135814_5	1123274.KB899421_gene1762	3.727e-26	110.0	COG0184@1|root,COG0184@2|Bacteria,2J91K@203691|Spirochaetes	203691|Spirochaetes	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
SX2_k127_1135814_0	573413.Spirs_2033	9.875e-280	879.0	COG1185@1|root,COG1185@2|Bacteria,2J5BU@203691|Spirochaetes	203691|Spirochaetes	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
SX2_k127_1135814_4	1121422.AUMW01000003_gene938	4.497e-43	173.0	COG0612@1|root,COG0612@2|Bacteria,1TP5I@1239|Firmicutes,248HT@186801|Clostridia,260B8@186807|Peptococcaceae	186801|Clostridia	S	Belongs to the peptidase M16 family	ymxG	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
SX2_k127_1144340_3	158189.SpiBuddy_1820	6.872e-07	62.0	COG0498@1|root,COG0498@2|Bacteria,2J84W@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SX2_k127_1144340_0	573413.Spirs_1385	2.08e-210	669.0	COG0031@1|root,COG0031@2|Bacteria,2J9V1@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
SX2_k127_1144340_1	425104.Ssed_2790	1.541e-74	261.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria,2Q9RW@267890|Shewanellaceae	1236|Gammaproteobacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm2	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
SX2_k127_1144340_2	425104.Ssed_2791	2.438e-22	112.0	COG4262@1|root,COG4262@2|Bacteria,1QUPY@1224|Proteobacteria,1RMJV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
SX2_k127_1144569_0	1195236.CTER_5299	1.329e-88	321.0	COG0493@1|root,COG0493@2|Bacteria,1V14A@1239|Firmicutes,24FJ4@186801|Clostridia,3WP0B@541000|Ruminococcaceae	186801|Clostridia	C	Dihydroorotate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	DHO_dh,Fer4,Fer4_20
SX2_k127_1144569_2	545695.TREAZ_2691	1.982e-11	75.0	COG4105@1|root,COG4105@2|Bacteria	2|Bacteria	S	cell envelope organization	bamD	-	-	ko:K05807,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02000	1.B.33.1	GH23	-	YfiO
SX2_k127_1144569_1	889378.Spiaf_1207	2.878e-21	94.0	COG1196@1|root,COG1196@2|Bacteria,2J57J@203691|Spirochaetes	203691|Spirochaetes	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N
SX2_k127_114973_2	926550.CLDAP_32200	1.057e-68	245.0	COG0246@1|root,COG0246@2|Bacteria	2|Bacteria	G	mannitol metabolic process	-	-	1.1.1.17	ko:K00009	ko00051,map00051	-	R02703	RC00085	ko00000,ko00001,ko01000	-	-	-	Mannitol_dh,Mannitol_dh_C
SX2_k127_114973_0	1480694.DC28_00885	4.137e-179	584.0	COG0469@1|root,COG0469@2|Bacteria,2J5VE@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
SX2_k127_114973_1	5341.XP_007329922.1	3.277e-146	478.0	COG0334@1|root,KOG2250@2759|Eukaryota,390UX@33154|Opisthokonta,3NVNH@4751|Fungi,3UZ5W@5204|Basidiomycota,224JB@155619|Agaricomycetes,3W5PD@5338|Agaricales	4751|Fungi	E	NAD( )-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate	GDH2	GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006103,GO:0006106,GO:0006520,GO:0006536,GO:0006538,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0016639,GO:0019551,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0051186,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH,ELFV_dehydrog
SX2_k127_1164899_0	1121324.CLIT_18c00210	1.714e-97	338.0	COG3426@1|root,COG3426@2|Bacteria,1TPKE@1239|Firmicutes,24993@186801|Clostridia,25QTD@186804|Peptostreptococcaceae	186801|Clostridia	H	Belongs to the acetokinase family	buk	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0044237,GO:0044424,GO:0044464,GO:0047761	2.7.2.7	ko:K00929	ko00650,ko01100,map00650,map01100	-	R01688	RC00002,RC00043	ko00000,ko00001,ko01000	-	-	-	Acetate_kinase
SX2_k127_1164899_1	388051.AUFE01000026_gene5209	4.633e-10	66.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VIMC@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	gltS2	-	2.7.13.3	ko:K10125	ko02020,map02020	M00504	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,dCache_1
SX2_k127_1165051_1	278957.ABEA03000084_gene2325	2.414e-93	312.0	COG3822@1|root,COG3822@2|Bacteria	2|Bacteria	S	D-lyxose isomerase	-	-	5.3.1.15	ko:K09988	ko00040,map00040	-	R01898	RC00516	ko00000,ko00001,ko01000	-	-	-	Lyx_isomer
SX2_k127_1165051_0	1304880.JAGB01000003_gene1278	4.197e-319	993.0	COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia	186801|Clostridia	G	hydrolase, family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
SX2_k127_1165051_2	754027.HMPREF9554_02596	1.568e-43	160.0	COG3408@1|root,COG3408@2|Bacteria,2J5J1@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Trehalase	-	-	-	-	-	-	-	-	-	-	-	-	Trehalase
SX2_k127_1173679_0	485913.Krac_1035	1.102e-84	295.0	COG2942@1|root,COG2942@2|Bacteria,2G8X6@200795|Chloroflexi	200795|Chloroflexi	G	PFAM N-acylglucosamine 2-epimerase	-	-	5.1.3.11,5.1.3.8	ko:K01787,ko:K16213	ko00520,map00520	-	R01207,R01445,R10810	RC00289,RC00290	ko00000,ko00001,ko01000	-	-	-	GlcNAc_2-epim
SX2_k127_1173679_3	358396.C445_17329	4.735e-48	188.0	COG2159@1|root,arCOG01931@2157|Archaea,2XUEU@28890|Euryarchaeota,23UJ8@183963|Halobacteria	183963|Halobacteria	S	metal-dependent hydrolase of the TIM-barrel fold	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
SX2_k127_1173679_5	1232453.BAIF02000031_gene2557	4.824e-15	87.0	COG0407@1|root,COG0407@2|Bacteria,1URPV@1239|Firmicutes,24XIW@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX2_k127_1173679_6	658086.HMPREF0994_03543	1.159e-05	58.0	28MXM@1|root,2Z8AT@2|Bacteria,1V0XI@1239|Firmicutes,24DIS@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1173679_4	324602.Caur_3229	3.492e-43	173.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,2G8GW@200795|Chloroflexi,3776B@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase, dimerisation and phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_3
SX2_k127_1173679_2	1128421.JAGA01000002_gene1391	2.407e-64	240.0	COG2197@1|root,COG2197@2|Bacteria,2NR2Y@2323|unclassified Bacteria	2|Bacteria	T	helix_turn_helix, Lux Regulon	-	-	-	ko:K11618	ko02020,map02020	M00481,M00754	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
SX2_k127_1173679_1	768704.Desmer_1341	6.168e-72	257.0	COG1835@1|root,COG1835@2|Bacteria,1V7CG@1239|Firmicutes,24WKR@186801|Clostridia,263B9@186807|Peptococcaceae	186801|Clostridia	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
SX2_k127_1176781_2	906968.Trebr_1835	6.8e-07	58.0	2DF9V@1|root,2ZR1A@2|Bacteria,2J8C8@203691|Spirochaetes	203691|Spirochaetes	S	Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane
SX2_k127_1176781_0	906968.Trebr_1836	6.322e-85	302.0	COG0860@1|root,COG0860@2|Bacteria,2J5PE@203691|Spirochaetes	203691|Spirochaetes	M	N-acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,Cu_amine_oxidN1
SX2_k127_1176781_1	1123274.KB899412_gene1457	3.859e-36	145.0	COG1181@1|root,COG1181@2|Bacteria,2J5KK@203691|Spirochaetes	203691|Spirochaetes	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3,ATP-grasp_4
SX2_k127_119447_0	744872.Spica_2595	1.472e-138	456.0	COG1916@1|root,COG1916@2|Bacteria,2J5K2@203691|Spirochaetes	203691|Spirochaetes	S	Pheromone shutdown protein	traB	-	-	-	-	-	-	-	-	-	-	-	TraB
SX2_k127_119447_4	1480694.DC28_09585	3.545e-39	166.0	2FEQT@1|root,346PZ@2|Bacteria,2J6IX@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_119447_3	1499967.BAYZ01000171_gene5583	1.635e-56	207.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	ko:K10709	-	-	-	-	ko00000	-	-	-	AP_endonuc_2
SX2_k127_119447_1	1449058.JQKT01000009_gene124	8.256e-112	394.0	COG3507@1|root,COG3507@2|Bacteria,2I8KC@201174|Actinobacteria	201174|Actinobacteria	G	Glycosyl hydrolases family 43	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
SX2_k127_119447_2	665571.STHERM_c08500	7.254e-91	322.0	COG2207@1|root,COG2207@2|Bacteria,2J6IS@203691|Spirochaetes	203691|Spirochaetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
SX2_k127_1205733_3	926560.KE387023_gene2060	1.053e-09	61.0	COG4877@1|root,COG4877@2|Bacteria,1WKMS@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	RHH_5
SX2_k127_1205733_4	1105367.CG50_00600	1.67e-09	69.0	COG0633@1|root,COG2114@1|root,COG0633@2|Bacteria,COG2114@2|Bacteria,1N5XC@1224|Proteobacteria,2TRGX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CT	Adenylate Guanylate cyclase	cyaA	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Guanylate_cyc
SX2_k127_1205733_1	518766.Rmar_1295	5.011e-97	327.0	COG0428@1|root,COG0428@2|Bacteria,4NGQ8@976|Bacteroidetes,1FJI0@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	ZIP Zinc transporter	gufA	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
SX2_k127_1205733_2	2002.JOEQ01000016_gene7397	1.561e-32	146.0	COG0697@1|root,COG0697@2|Bacteria,2I91Y@201174|Actinobacteria,4EIE9@85012|Streptosporangiales	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SX2_k127_1205733_0	665571.STHERM_c07990	3.366e-153	488.0	COG0013@1|root,COG0013@2|Bacteria,2J5G2@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
SX2_k127_1207421_3	760011.Spico_0969	1.27e-09	64.0	COG0481@1|root,COG0481@2|Bacteria,2J5V8@203691|Spirochaetes	203691|Spirochaetes	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
SX2_k127_1207421_1	640132.Srot_1667	5.925e-18	94.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria	201174|Actinobacteria	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	tcrX	GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010106,GO:0019725,GO:0030003,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042592,GO:0042594,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071496,GO:0098771	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
SX2_k127_1207421_0	573413.Spirs_1819	4.147e-114	406.0	COG0265@1|root,COG0265@2|Bacteria,2J5SD@203691|Spirochaetes	203691|Spirochaetes	O	Trypsin domain PDZ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
SX2_k127_1240978_0	1449347.JQLN01000004_gene7281	2.828e-59	216.0	COG0524@1|root,COG0524@2|Bacteria,2I04R@201174|Actinobacteria,2M34K@2063|Kitasatospora	201174|Actinobacteria	G	pfkB family carbohydrate kinase	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
SX2_k127_1240978_4	290397.Adeh_3342	1.776e-23	118.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria,2YUYF@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	ntrY	-	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
SX2_k127_1240978_1	1265505.ATUG01000001_gene3978	2.266e-32	147.0	COG2203@1|root,COG2203@2|Bacteria,1NT6X@1224|Proteobacteria,42XRB@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2
SX2_k127_1240978_3	1480694.DC28_11270	1.653e-23	116.0	2FJ33@1|root,34ATE@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1240978_2	1499967.BAYZ01000139_gene120	1.345e-26	110.0	COG2078@1|root,COG2078@2|Bacteria,2NPQ0@2323|unclassified Bacteria	2|Bacteria	S	AMMECR1	-	-	-	ko:K06990,ko:K09141	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,Memo
SX2_k127_1280514_13	278957.ABEA03000135_gene1776	1.432e-26	117.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
SX2_k127_1280514_8	1499967.BAYZ01000102_gene3584	6.489e-73	252.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
SX2_k127_1280514_6	871968.DESME_04290	3.43e-108	380.0	COG1233@1|root,COG1233@2|Bacteria,1TS4A@1239|Firmicutes,249K1@186801|Clostridia,2633J@186807|Peptococcaceae	186801|Clostridia	Q	amine oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
SX2_k127_1280514_12	158190.SpiGrapes_0053	1.959e-42	166.0	2EHEG@1|root,33B6E@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Abi
SX2_k127_1280514_18	1232453.BAIF02000098_gene3873	1.728e-20	99.0	COG1309@1|root,COG1309@2|Bacteria,1VAN5@1239|Firmicutes,24I23@186801|Clostridia	186801|Clostridia	K	WHG domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1280514_7	555088.DealDRAFT_1324	2.268e-93	317.0	COG1131@1|root,COG1131@2|Bacteria,1TQN1@1239|Firmicutes,25AZK@186801|Clostridia	186801|Clostridia	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX2_k127_1280514_10	158190.SpiGrapes_0269	1.864e-46	186.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
SX2_k127_1280514_9	1230342.CTM_18924	1.752e-51	202.0	COG1266@1|root,COG1266@2|Bacteria,1VH5V@1239|Firmicutes,24QGF@186801|Clostridia,36MXP@31979|Clostridiaceae	186801|Clostridia	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
SX2_k127_1280514_16	749927.AMED_0472	5.722e-23	106.0	COG1266@1|root,COG1266@2|Bacteria,2I8AH@201174|Actinobacteria,4E39D@85010|Pseudonocardiales	201174|Actinobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
SX2_k127_1280514_1	929556.Solca_3465	4.169e-187	605.0	COG1132@1|root,COG1132@2|Bacteria,4NEBS@976|Bacteroidetes,1IPPE@117747|Sphingobacteriia	976|Bacteroidetes	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SX2_k127_1280514_17	383372.Rcas_1143	2.278e-21	108.0	2ECZ8@1|root,336W9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1280514_15	177437.HRM2_39790	5.486e-24	118.0	COG2227@1|root,COG2227@2|Bacteria,1QWNW@1224|Proteobacteria,42SSA@68525|delta/epsilon subdivisions,2X74S@28221|Deltaproteobacteria,2MMCM@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
SX2_k127_1280514_14	1267535.KB906767_gene4959	4.63e-26	125.0	COG0859@1|root,COG0859@2|Bacteria,3Y7R7@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
SX2_k127_1280514_4	697281.Mahau_0028	1.251e-123	406.0	COG0407@1|root,COG0407@2|Bacteria,1V5JE@1239|Firmicutes,24E5A@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX2_k127_1280514_2	1480694.DC28_07190	2.32e-171	548.0	COG0282@1|root,COG0282@2|Bacteria,2J57M@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
SX2_k127_1280514_11	1121440.AUMA01000002_gene2088	1.906e-42	164.0	COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,42SGH@68525|delta/epsilon subdivisions,2WP2B@28221|Deltaproteobacteria,2MBKZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1897	PRA-CH,PRA-PH
SX2_k127_1280514_5	1125863.JAFN01000001_gene2027	2.659e-116	386.0	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,42N9N@68525|delta/epsilon subdivisions,2WIY9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
SX2_k127_1280514_0	926569.ANT_31250	2.913e-306	966.0	COG0474@1|root,COG0474@2|Bacteria,2G5ZS@200795|Chloroflexi	200795|Chloroflexi	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
SX2_k127_1280514_3	557598.LHK_00786	6.322e-131	422.0	COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,2VIIR@28216|Betaproteobacteria,2KPIK@206351|Neisseriales	206351|Neisseriales	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
SX2_k127_1280514_19	765911.Thivi_0961	2.574e-09	58.0	COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,1S5VH@1236|Gammaproteobacteria,1WY75@135613|Chromatiales	135613|Chromatiales	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	-	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
SX2_k127_1298341_3	744872.Spica_1405	1.67e-14	80.0	COG0236@1|root,COG0236@2|Bacteria,2J8CN@203691|Spirochaetes	203691|Spirochaetes	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
SX2_k127_1298341_2	744872.Spica_1406	2.475e-21	95.0	COG0333@1|root,COG0333@2|Bacteria,2J8XR@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
SX2_k127_1298341_0	889378.Spiaf_1696	9.853e-50	193.0	COG0669@1|root,COG0669@2|Bacteria,2J7VS@203691|Spirochaetes	203691|Spirochaetes	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
SX2_k127_1298341_1	665571.STHERM_c11910	2.814e-32	140.0	2FCY0@1|root,3437Z@2|Bacteria,2JBFD@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_12991_11	1128421.JAGA01000002_gene1483	2.927e-38	156.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_106
SX2_k127_12991_5	580331.Thit_0082	1.773e-75	263.0	COG2818@1|root,COG2818@2|Bacteria,1UYWG@1239|Firmicutes,249EP@186801|Clostridia,42FGP@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM Methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
SX2_k127_12991_0	1297570.MESS4_560033	4.068e-164	530.0	COG0006@1|root,COG0006@2|Bacteria,1N8DW@1224|Proteobacteria,2U2SF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Xaa-Pro aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
SX2_k127_12991_7	278957.ABEA03000135_gene1776	8.822e-63	228.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
SX2_k127_12991_10	1382356.JQMP01000001_gene943	9.544e-50	189.0	COG1082@1|root,COG1082@2|Bacteria,2G8Q7@200795|Chloroflexi	200795|Chloroflexi	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SX2_k127_12991_12	1227352.C173_25337	5.303e-09	68.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V08K@1239|Firmicutes,4HAY7@91061|Bacilli,26V4B@186822|Paenibacillaceae	91061|Bacilli	T	COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,Response_reg
SX2_k127_12991_8	1370121.AUWS01000006_gene5175	1.859e-62	224.0	COG0491@1|root,COG0491@2|Bacteria,2IAXY@201174|Actinobacteria,23EED@1762|Mycobacteriaceae	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SX2_k127_12991_2	278957.ABEA03000005_gene4380	2.064e-145	494.0	COG0407@1|root,COG0407@2|Bacteria,46WW7@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
SX2_k127_12991_1	1195236.CTER_4255	5.995e-156	518.0	COG1653@1|root,COG1653@2|Bacteria,1UYSZ@1239|Firmicutes,25BW9@186801|Clostridia	186801|Clostridia	P	solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
SX2_k127_12991_3	1195236.CTER_4256	2.544e-105	349.0	COG0395@1|root,COG0395@2|Bacteria,1TPIF@1239|Firmicutes,25C5D@186801|Clostridia	186801|Clostridia	P	ABC-type sugar transport system, permease component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX2_k127_12991_4	1195236.CTER_4257	1.096e-97	328.0	COG1175@1|root,COG1175@2|Bacteria,1UXJJ@1239|Firmicutes,24HEH@186801|Clostridia	186801|Clostridia	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
SX2_k127_12991_6	357809.Cphy_0525	3.276e-74	273.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UYCG@1239|Firmicutes,24DKG@186801|Clostridia,220KT@1506553|Lachnoclostridium	186801|Clostridia	K	Two component transcriptional regulator, AraC family	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,HTH_AraC,Response_reg
SX2_k127_12991_9	357809.Cphy_0526	1.528e-61	223.0	COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,247XB@186801|Clostridia,2208P@1506553|Lachnoclostridium	186801|Clostridia	T	histidine kinase HAMP region domain protein	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,His_kinase,dCache_1
SX2_k127_1343676_2	1304880.JAGB01000003_gene1278	1.256e-22	99.0	COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia	186801|Clostridia	G	hydrolase, family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
SX2_k127_1343676_0	1480694.DC28_08870	3.264e-199	633.0	COG3408@1|root,COG3408@2|Bacteria,2J5J1@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Trehalase	-	-	-	-	-	-	-	-	-	-	-	-	Trehalase
SX2_k127_1343676_3	665571.STHERM_c22210	1.394e-15	83.0	COG0721@1|root,COG0721@2|Bacteria	2|Bacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	iAF987.Gmet_0076	Glu-tRNAGln
SX2_k127_1343676_1	665571.STHERM_c22200	2.432e-146	476.0	COG0154@1|root,COG0154@2|Bacteria,2J58P@203691|Spirochaetes	203691|Spirochaetes	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
SX2_k127_1345196_5	573413.Spirs_2239	5.682e-12	65.0	COG0572@1|root,COG0572@2|Bacteria,2J6XC@203691|Spirochaetes	203691|Spirochaetes	F	Cytidine monophosphokinase	udk	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
SX2_k127_1345196_2	1121918.ARWE01000001_gene393	3.05e-81	282.0	COG0350@1|root,COG2207@1|root,COG0350@2|Bacteria,COG2207@2|Bacteria,1N2YQ@1224|Proteobacteria,42MQN@68525|delta/epsilon subdivisions,2WRJ0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	2.1.1.63	ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	DNA_binding_1,HTH_18,Methyltransf_1N
SX2_k127_1345196_1	1449063.JMLS01000003_gene1871	1.055e-96	338.0	COG0329@1|root,COG0329@2|Bacteria,1VR54@1239|Firmicutes,4I6PW@91061|Bacilli,26U6M@186822|Paenibacillaceae	91061|Bacilli	EM	Belongs to the DapA family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
SX2_k127_1345196_3	1121413.JMKT01000014_gene2447	1.565e-79	273.0	COG2230@1|root,COG2230@2|Bacteria,1R1J6@1224|Proteobacteria,43DEG@68525|delta/epsilon subdivisions,2X8KD@28221|Deltaproteobacteria,2MHIT@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
SX2_k127_1345196_4	1304874.JAFY01000005_gene1320	1.852e-32	134.0	COG3467@1|root,COG3467@2|Bacteria,3TBB5@508458|Synergistetes	508458|Synergistetes	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
SX2_k127_1345196_0	1304880.JAGB01000002_gene2035	3.541e-97	332.0	COG2211@1|root,COG2211@2|Bacteria,1URUG@1239|Firmicutes,248SK@186801|Clostridia	186801|Clostridia	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX2_k127_1357926_3	742766.HMPREF9455_02470	5.918e-07	61.0	28JDZ@1|root,2Z988@2|Bacteria,4NHND@976|Bacteroidetes,2FQDQ@200643|Bacteroidia,22ZTZ@171551|Porphyromonadaceae	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1357926_2	639282.DEFDS_0706	8.999e-48	194.0	COG0672@1|root,COG0672@2|Bacteria,2GGKP@200930|Deferribacteres	200930|Deferribacteres	P	Iron permease FTR1 family	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1
SX2_k127_1357926_1	744872.Spica_0418	5.95e-73	251.0	COG0517@1|root,COG0517@2|Bacteria,2J6JU@203691|Spirochaetes	203691|Spirochaetes	S	CBS domain	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	ACT,CBS
SX2_k127_1357926_0	926569.ANT_24830	1.564e-163	526.0	COG2230@1|root,COG2230@2|Bacteria,2G8QA@200795|Chloroflexi	200795|Chloroflexi	H	Mycolic acid cyclopropane synthetase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
SX2_k127_13732_1	1151117.AJLF01000001_gene1683	2.133e-69	247.0	COG0449@1|root,arCOG00057@2157|Archaea,2XTC0@28890|Euryarchaeota,243IS@183968|Thermococci	183968|Thermococci	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
SX2_k127_13732_0	290317.Cpha266_1750	5.164e-71	259.0	COG0737@1|root,COG1404@1|root,COG1409@1|root,COG1785@1|root,COG2374@1|root,COG2931@1|root,COG3391@1|root,COG4222@1|root,COG0737@2|Bacteria,COG1404@2|Bacteria,COG1409@2|Bacteria,COG1785@2|Bacteria,COG2374@2|Bacteria,COG2931@2|Bacteria,COG3391@2|Bacteria,COG4222@2|Bacteria,1FEG9@1090|Chlorobi	1090|Chlorobi	FP	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid_C,Alk_phosphatase,Big_5,Metallophos,Phytase-like
SX2_k127_13732_4	1121372.AULK01000006_gene1431	2.438e-19	90.0	COG1254@1|root,COG1254@2|Bacteria,2HZJD@201174|Actinobacteria,4FQ1C@85023|Microbacteriaceae	201174|Actinobacteria	C	Acylphosphatase	-	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
SX2_k127_13732_2	1123274.KB899410_gene3550	9.7e-45	166.0	COG2204@1|root,COG2204@2|Bacteria,2JAI3@203691|Spirochaetes	203691|Spirochaetes	T	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
SX2_k127_13732_3	1123274.KB899410_gene3549	1.769e-41	157.0	COG0745@1|root,COG0745@2|Bacteria,2J7DK@203691|Spirochaetes	203691|Spirochaetes	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,Response_reg
SX2_k127_1394131_1	997346.HMPREF9374_2070	5.639e-22	98.0	COG0721@1|root,COG0721@2|Bacteria,1VEK3@1239|Firmicutes,4HNNA@91061|Bacilli,27C6Z@186824|Thermoactinomycetaceae	91061|Bacilli	J	Glu-tRNAGln amidotransferase C subunit	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
SX2_k127_1394131_0	266117.Rxyl_0830	2.858e-163	527.0	COG0154@1|root,COG0154@2|Bacteria,2GJK5@201174|Actinobacteria,4CPBB@84995|Rubrobacteria	84995|Rubrobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
SX2_k127_1394131_2	1288083.AUKR01000013_gene743	2.215e-06	59.0	COG0392@1|root,COG0392@2|Bacteria,2GMAV@201174|Actinobacteria	201174|Actinobacteria	T	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
SX2_k127_1394131_3	1121422.AUMW01000008_gene476	0.0001027	53.0	COG5001@1|root,COG5001@2|Bacteria	2|Bacteria	T	cyclic-guanylate-specific phosphodiesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_9,Response_reg
SX2_k127_1404798_1	545694.TREPR_2320	2.24e-130	436.0	COG0358@1|root,COG0358@2|Bacteria,2J5MX@203691|Spirochaetes	203691|Spirochaetes	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
SX2_k127_1404798_0	744872.Spica_1392	7.475e-143	467.0	COG0568@1|root,COG0568@2|Bacteria,2J59P@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
SX2_k127_1407773_5	1189619.pgond44_14073	7.927e-08	66.0	COG0642@1|root,COG4191@1|root,COG2205@2|Bacteria,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes,1I0JH@117743|Flavobacteriia	976|Bacteroidetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA,TPR_12,TPR_7
SX2_k127_1407773_0	1385935.N836_20050	2.893e-114	399.0	COG1233@1|root,COG1233@2|Bacteria,1GCDS@1117|Cyanobacteria	1117|Cyanobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
SX2_k127_1407773_1	158190.SpiGrapes_0227	3.304e-53	197.0	COG4676@1|root,COG4676@2|Bacteria	2|Bacteria	UW	Protein conserved in bacteria	-	-	-	ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	CarboxypepD_reg,TPR_11,TPR_12,TPR_2,TPR_7,TPR_8
SX2_k127_1407773_4	555088.DealDRAFT_0112	1.332e-19	93.0	2FJYI@1|root,34BKW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1407773_2	485913.Krac_7364	4.172e-44	171.0	COG1595@1|root,COG1595@2|Bacteria,2G93G@200795|Chloroflexi	200795|Chloroflexi	K	RNA polymerase, sigma-24 subunit, ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SX2_k127_1407773_3	1035308.AQYY01000002_gene647	3.36e-32	136.0	COG0701@1|root,COG0701@2|Bacteria	2|Bacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
SX2_k127_1447420_0	1047013.AQSP01000106_gene1771	2.305e-180	591.0	COG0653@1|root,COG0653@2|Bacteria,2NNRK@2323|unclassified Bacteria	2|Bacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA2	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009405,GO:0009605,GO:0009607,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030312,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0035821,GO:0036094,GO:0040007,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043207,GO:0043492,GO:0043952,GO:0044003,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0050896,GO:0051179,GO:0051234,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052564,GO:0052572,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0075136,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SecA_DEAD,SecA_PP_bind,SecA_SW
SX2_k127_1447420_1	1286171.EAL2_808p00570	3.871e-75	261.0	COG1600@1|root,COG1600@2|Bacteria,1V0A3@1239|Firmicutes,249D6@186801|Clostridia,25WW3@186806|Eubacteriaceae	186801|Clostridia	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1447420_2	324602.Caur_3102	2.873e-32	141.0	COG0727@1|root,32S46@2|Bacteria,2G78K@200795|Chloroflexi,377J9@32061|Chloroflexia	32061|Chloroflexia	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
SX2_k127_1447420_3	573413.Spirs_0535	6.93e-24	109.0	COG2334@1|root,COG2334@2|Bacteria,2J9JA@203691|Spirochaetes	203691|Spirochaetes	S	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response	srkA	-	-	-	-	-	-	-	-	-	-	-	APH
SX2_k127_1449202_2	545694.TREPR_2514	1.727e-05	54.0	COG4372@1|root,COG4372@2|Bacteria,2J5RI@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Borrelia P83 100 protein	-	-	-	-	-	-	-	-	-	-	-	-	Borrelia_P83
SX2_k127_1449202_1	439481.Aboo_1543	1.586e-94	322.0	COG0182@1|root,arCOG01123@2157|Archaea,2Y86P@28890|Euryarchaeota,3F36H@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	-	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.23	ko:K03239,ko:K08963	ko00270,ko01100,ko03013,map00270,map01100,map03013	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000,ko03012	-	-	-	IF-2B
SX2_k127_1449202_0	744872.Spica_0294	4.358e-193	620.0	COG1022@1|root,COG1022@2|Bacteria,2J59B@203691|Spirochaetes	203691|Spirochaetes	I	COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming)	faa1	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
SX2_k127_1459097_3	665571.STHERM_c08160	4.698e-07	62.0	COG0797@1|root,COG0797@2|Bacteria,2J7K2@203691|Spirochaetes	203691|Spirochaetes	M	Sporulation and cell division repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
SX2_k127_1459097_2	469381.Dpep_0775	1.156e-07	63.0	COG3206@1|root,COG3206@2|Bacteria,3TAZ7@508458|Synergistetes	508458|Synergistetes	M	PFAM lipopolysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	GNVR,Wzz
SX2_k127_1459097_0	744872.Spica_1447	7.321e-195	618.0	COG1086@1|root,COG1086@2|Bacteria,2J5C2@203691|Spirochaetes	203691|Spirochaetes	M	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding,CoA_binding_3,Polysacc_synt_2
SX2_k127_1459097_1	1123274.KB899409_gene608	4.771e-97	328.0	COG0399@1|root,COG0399@2|Bacteria,2J62G@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the DegT DnrJ EryC1 family	spsC	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
SX2_k127_1463631_9	926550.CLDAP_28220	1.437e-24	105.0	COG2407@1|root,COG2407@2|Bacteria,2G84V@200795|Chloroflexi	200795|Chloroflexi	G	L-fucose isomerase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Fucose_iso_C
SX2_k127_1463631_1	457398.HMPREF0326_00529	6.515e-132	437.0	COG1620@1|root,COG1620@2|Bacteria,1MV13@1224|Proteobacteria,42NEP@68525|delta/epsilon subdivisions,2WMIU@28221|Deltaproteobacteria,2MGD5@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM L-lactate permease	-	-	-	ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14	-	-	Lactate_perm
SX2_k127_1463631_0	1121396.KB893063_gene1215	3.642e-138	451.0	COG2223@1|root,COG2223@2|Bacteria,1MWC7@1224|Proteobacteria,42PMA@68525|delta/epsilon subdivisions,2X5AR@28221|Deltaproteobacteria,2MQ2M@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Major Facilitator Superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
SX2_k127_1463631_10	742733.HMPREF9469_01657	3.369e-06	60.0	COG5434@1|root,COG5434@2|Bacteria,1V4PZ@1239|Firmicutes,24CQH@186801|Clostridia,220B6@1506553|Lachnoclostridium	186801|Clostridia	G	Pectate lyase superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_28,Pectate_lyase_3
SX2_k127_1463631_2	926561.KB900618_gene411	5.678e-108	367.0	COG1533@1|root,COG1533@2|Bacteria,1TSS2@1239|Firmicutes,248SB@186801|Clostridia	186801|Clostridia	L	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SX2_k127_1463631_6	1499967.BAYZ01000095_gene4180	3.504e-53	212.0	COG0673@1|root,COG0673@2|Bacteria,2NR0C@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX2_k127_1463631_4	96561.Dole_0663	1.835e-56	209.0	COG1280@1|root,COG1280@2|Bacteria,1RJBR@1224|Proteobacteria,42T9G@68525|delta/epsilon subdivisions,2WP76@28221|Deltaproteobacteria,2MKPW@213118|Desulfobacterales	28221|Deltaproteobacteria	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
SX2_k127_1463631_8	269796.Rru_A3055	3.086e-31	136.0	COG0697@1|root,COG0697@2|Bacteria,1PX64@1224|Proteobacteria,2UA6Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SX2_k127_1463631_7	593750.Metfor_0570	6.154e-44	172.0	COG1985@1|root,arCOG01489@2157|Archaea,2Y3MD@28890|Euryarchaeota	28890|Euryarchaeota	H	RibD C-terminal domain	-	-	1.1.1.302	ko:K14654	ko00740,ko01100,map00740,map01100	-	R09375,R09376	RC00933	ko00000,ko00001,ko01000	-	-	-	RibD_C
SX2_k127_1463631_5	1379698.RBG1_1C00001G0531	1.044e-54	217.0	COG0451@1|root,COG0451@2|Bacteria,2NPC7@2323|unclassified Bacteria	2|Bacteria	GM	NAD(P)H-binding	JD73_00815	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
SX2_k127_1463631_3	1123274.KB899409_gene506	1.002e-80	291.0	COG0044@1|root,COG0044@2|Bacteria,2J6KK@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
SX2_k127_1463631_11	458817.Shal_3053	1.11e-05	56.0	COG1781@1|root,COG1781@2|Bacteria,1RB7J@1224|Proteobacteria,1S2BM@1236|Gammaproteobacteria,2QDXX@267890|Shewanellaceae	1236|Gammaproteobacteria	F	Involved in allosteric regulation of aspartate carbamoyltransferase	pyrI	GO:0003674,GO:0003824,GO:0004070,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	-	ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002	-	-	-	PyrI,PyrI_C
SX2_k127_1489622_2	1343739.PAP_07295	4.5e-18	96.0	COG0454@1|root,arCOG00845@2157|Archaea,2Y67B@28890|Euryarchaeota,2430F@183968|Thermococci	183968|Thermococci	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SX2_k127_1489622_1	545695.TREAZ_3479	1.964e-46	177.0	COG1496@1|root,COG1496@2|Bacteria,2J7NB@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the multicopper oxidase YfiH RL5 family	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
SX2_k127_1489622_0	889378.Spiaf_1722	1.616e-63	237.0	COG0679@1|root,COG0679@2|Bacteria,2J8BY@203691|Spirochaetes	203691|Spirochaetes	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
SX2_k127_1499314_3	502025.Hoch_0149	9.175e-19	98.0	COG1186@1|root,COG1186@2|Bacteria,1ND5C@1224|Proteobacteria,430VS@68525|delta/epsilon subdivisions,2WW3U@28221|Deltaproteobacteria,2Z2GT@29|Myxococcales	28221|Deltaproteobacteria	J	PFAM Class I peptide chain release factor	-	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
SX2_k127_1499314_0	744872.Spica_0734	6.649e-85	307.0	COG0642@1|root,COG2205@2|Bacteria,2J63U@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
SX2_k127_1499314_1	906968.Trebr_1002	5.126e-74	261.0	COG0745@1|root,COG0745@2|Bacteria,2J7CF@203691|Spirochaetes	203691|Spirochaetes	K	COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SX2_k127_1499314_2	768710.DesyoDRAFT_5012	2.202e-51	186.0	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,2483J@186801|Clostridia,260DV@186807|Peptococcaceae	186801|Clostridia	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX2_k127_1500113_4	1278073.MYSTI_04729	8.339e-29	124.0	COG4249@1|root,COG4249@2|Bacteria,1QX7K@1224|Proteobacteria,43AHW@68525|delta/epsilon subdivisions,2X5Y0@28221|Deltaproteobacteria,2YZCA@29|Myxococcales	28221|Deltaproteobacteria	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
SX2_k127_1500113_3	404589.Anae109_0876	3.822e-38	154.0	COG5662@1|root,COG5662@2|Bacteria,1Q39S@1224|Proteobacteria,4390Y@68525|delta/epsilon subdivisions,2X465@28221|Deltaproteobacteria,2YYC2@29|Myxococcales	28221|Deltaproteobacteria	K	AntiSigma factor	actD	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1500113_2	378806.STAUR_0585	1.644e-47	176.0	COG1595@1|root,COG1595@2|Bacteria,1RHSF@1224|Proteobacteria,438JV@68525|delta/epsilon subdivisions,2X3UH@28221|Deltaproteobacteria,2YX4W@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	HTH_24,Sigma70_r2,Sigma70_r4_2
SX2_k127_1500113_0	1304880.JAGB01000002_gene1542	2.451e-208	657.0	COG1486@1|root,COG1486@2|Bacteria,1TQ9I@1239|Firmicutes,24995@186801|Clostridia	186801|Clostridia	G	family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
SX2_k127_1500113_6	926550.CLDAP_32200	2.838e-10	66.0	COG0246@1|root,COG0246@2|Bacteria	2|Bacteria	G	mannitol metabolic process	-	-	1.1.1.17	ko:K00009	ko00051,map00051	-	R02703	RC00085	ko00000,ko00001,ko01000	-	-	-	Mannitol_dh,Mannitol_dh_C
SX2_k127_1500113_1	926550.CLDAP_32200	3.688e-79	279.0	COG0246@1|root,COG0246@2|Bacteria	2|Bacteria	G	mannitol metabolic process	-	-	1.1.1.17	ko:K00009	ko00051,map00051	-	R02703	RC00085	ko00000,ko00001,ko01000	-	-	-	Mannitol_dh,Mannitol_dh_C
SX2_k127_1500113_5	1449126.JQKL01000041_gene998	2.434e-17	96.0	COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,267SX@186813|unclassified Clostridiales	186801|Clostridia	G	Pyruvate kinase, barrel domain	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
SX2_k127_1502763_6	158190.SpiGrapes_1983	9.466e-88	298.0	COG0395@1|root,COG0395@2|Bacteria,2J6MZ@203691|Spirochaetes	203691|Spirochaetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K17320	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
SX2_k127_1502763_4	504728.K649_01020	5.168e-123	402.0	COG4209@1|root,COG4209@2|Bacteria,1WK2U@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
SX2_k127_1502763_0	1906.SFRA_26855	1.182e-186	628.0	COG0642@1|root,COG1609@1|root,COG2207@1|root,COG1609@2|Bacteria,COG2205@2|Bacteria,COG2207@2|Bacteria,2ICPA@201174|Actinobacteria	201174|Actinobacteria	T	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,Peripla_BP_3,Response_reg
SX2_k127_1502763_14	525904.Tter_2603	4.093e-22	109.0	COG0673@1|root,COG0673@2|Bacteria,2NR8T@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX2_k127_1502763_11	1480694.DC28_13890	1.877e-50	187.0	2BYH0@1|root,2ZDJM@2|Bacteria,2J7FT@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1502763_9	765952.PUV_16910	3.841e-60	221.0	COG0820@1|root,COG0820@2|Bacteria	2|Bacteria	J	rRNA (adenine-C2-)-methyltransferase activity	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192,2.1.1.224	ko:K06941,ko:K15632	-	-	-	-	ko00000,ko01000,ko01504,ko03009	-	-	-	Fer4_14,Radical_SAM
SX2_k127_1502763_12	545694.TREPR_1653	1.641e-41	157.0	COG0760@1|root,COG0760@2|Bacteria,2J7Z8@203691|Spirochaetes	203691|Spirochaetes	O	peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3
SX2_k127_1502763_3	448385.sce9160	9.206e-125	411.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,42MUK@68525|delta/epsilon subdivisions,2X5CN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	3.6.3.31	ko:K11072	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1	-	-	ABC_tran,TOBE_2
SX2_k127_1502763_5	525897.Dbac_2003	1.514e-104	348.0	COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,42PMI@68525|delta/epsilon subdivisions,2WM2W@28221|Deltaproteobacteria,2MA56@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
SX2_k127_1502763_7	526227.Mesil_2403	1.882e-83	298.0	COG1177@1|root,COG1177@2|Bacteria,1WICS@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	ABC-type spermidine putrescine transport system, permease component II	-	-	-	ko:K11070	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
SX2_k127_1502763_8	1122223.KB890700_gene1996	1.6e-81	284.0	COG0687@1|root,COG0687@2|Bacteria,1WIRI@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Spermidine putrescine-binding periplasmic protein	-	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_8
SX2_k127_1502763_2	1476583.DEIPH_ctg052orf0098	5.763e-133	443.0	COG0520@1|root,COG0520@2|Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	csdA	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
SX2_k127_1502763_13	398512.JQKC01000005_gene5620	5.967e-40	164.0	COG4908@1|root,COG4908@2|Bacteria,1V0U5@1239|Firmicutes,25D3E@186801|Clostridia,3WK8S@541000|Ruminococcaceae	186801|Clostridia	S	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	Condensation
SX2_k127_1502763_10	1408473.JHXO01000001_gene2063	2.935e-59	224.0	COG1521@1|root,COG1521@2|Bacteria,4NE9E@976|Bacteroidetes,2FMPK@200643|Bacteroidia	976|Bacteroidetes	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
SX2_k127_1502763_1	404589.Anae109_2754	5.597e-176	563.0	COG1148@1|root,COG1148@2|Bacteria,1PTJ7@1224|Proteobacteria,42NJN@68525|delta/epsilon subdivisions,2WJHG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6
SX2_k127_1502763_15	620914.JH621254_gene551	5.709e-12	66.0	COG0564@1|root,COG0564@2|Bacteria,4NFS8@976|Bacteroidetes,1HXBY@117743|Flavobacteriia,2YH4S@290174|Aquimarina	976|Bacteroidetes	J	RNA pseudouridylate synthase	rluC	-	5.4.99.23,5.4.99.28,5.4.99.29	ko:K06177,ko:K06180	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	PseudoU_synth_2
SX2_k127_1515013_6	1120985.AUMI01000018_gene2968	2.856e-09	58.0	COG3426@1|root,COG3426@2|Bacteria,1TPKE@1239|Firmicutes,4H3QW@909932|Negativicutes	909932|Negativicutes	C	Belongs to the acetokinase family	buk	-	2.7.2.7	ko:K00929	ko00650,ko01100,map00650,map01100	-	R01688	RC00002,RC00043	ko00000,ko00001,ko01000	-	-	-	Acetate_kinase
SX2_k127_1515013_2	292459.STH1435	4.185e-68	246.0	COG3392@1|root,COG3392@2|Bacteria,1TRWE@1239|Firmicutes,248Q7@186801|Clostridia	186801|Clostridia	L	D12 class N6 adenine-specific DNA methyltransferase	fokIM	-	2.1.1.72	ko:K07318	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	MethyltransfD12
SX2_k127_1515013_1	292459.STH1434	1.477e-100	347.0	COG0863@1|root,COG0863@2|Bacteria	2|Bacteria	L	N-4 methylation of cytosine	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
SX2_k127_1515013_5	665571.STHERM_c18670	2.23e-18	90.0	COG2849@1|root,COG2849@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	MORN_2,TonB_C
SX2_k127_1515013_3	573413.Spirs_3194	1.887e-63	226.0	COG0566@1|root,COG0566@2|Bacteria,2J748@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	yacO	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
SX2_k127_1515013_4	443254.Marpi_0378	2.783e-29	134.0	COG0041@1|root,COG0041@2|Bacteria,2GDB5@200918|Thermotogae	200918|Thermotogae	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
SX2_k127_1515013_0	889378.Spiaf_1956	1.226e-113	381.0	COG0151@1|root,COG0151@2|Bacteria	2|Bacteria	F	phosphoribosylamine-glycine ligase activity	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
SX2_k127_151934_2	465541.ATCJ01000001_gene586	3.073e-15	86.0	COG3212@1|root,COG3212@2|Bacteria,2IF4I@201174|Actinobacteria	201174|Actinobacteria	S	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_151934_1	1499689.CCNN01000004_gene278	1.712e-19	99.0	COG0640@1|root,COG0640@2|Bacteria,1VA6G@1239|Firmicutes,24JCN@186801|Clostridia,36JIC@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator	cadC	-	-	ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
SX2_k127_151934_0	292459.STH1625	1.693e-94	320.0	COG2217@1|root,COG2217@2|Bacteria,1TQ07@1239|Firmicutes,248EH@186801|Clostridia	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	cadA	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,HMA,Hydrolase
SX2_k127_1528236_2	1254432.SCE1572_34580	1.431e-43	166.0	2BZBC@1|root,32R4Q@2|Bacteria,1RICW@1224|Proteobacteria,431SQ@68525|delta/epsilon subdivisions,2WX05@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1528236_0	398527.Bphyt_0099	6.108e-151	492.0	COG2801@1|root,COG2801@2|Bacteria,1MUSB@1224|Proteobacteria,2VP7Z@28216|Betaproteobacteria,1K505@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_32,HTH_Tnp_Mu_1,Mu-transpos_C,rve
SX2_k127_1528236_1	1255043.TVNIR_3281	1.621e-96	325.0	COG3267@1|root,COG3267@2|Bacteria,1NWGN@1224|Proteobacteria,1S1RJ@1236|Gammaproteobacteria,1X05B@135613|Chromatiales	135613|Chromatiales	U	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
SX2_k127_1528843_3	1122221.JHVI01000017_gene2093	3.546e-16	79.0	COG2905@1|root,COG2905@2|Bacteria,1WJV4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SX2_k127_1528843_0	1499967.BAYZ01000014_gene6411	5.18e-68	242.0	COG0407@1|root,COG0407@2|Bacteria,2NPIC@2323|unclassified Bacteria	2|Bacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
SX2_k127_1528843_1	1499967.BAYZ01000095_gene4055	3.957e-57	207.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	2.3.1.82	ko:K18815	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
SX2_k127_1528843_2	1121405.dsmv_1837	6.532e-28	114.0	COG1181@1|root,COG1181@2|Bacteria,1N4F5@1224|Proteobacteria,42NYM@68525|delta/epsilon subdivisions,2WKTX@28221|Deltaproteobacteria,2MHWK@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlB1	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
SX2_k127_1530115_1	1499967.BAYZ01000028_gene1264	2.123e-94	315.0	COG1181@1|root,COG1181@2|Bacteria,2NRF0@2323|unclassified Bacteria	2|Bacteria	M	ATP-grasp domain	ddlA	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
SX2_k127_1530115_0	1121468.AUBR01000022_gene2795	5.804e-183	591.0	COG4231@1|root,COG4231@2|Bacteria,1TNY3@1239|Firmicutes,247U1@186801|Clostridia,42EZ8@68295|Thermoanaerobacterales	186801|Clostridia	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
SX2_k127_1532198_5	880073.Calab_2557	4.216e-33	138.0	COG0477@1|root,COG2814@2|Bacteria,2NS3M@2323|unclassified Bacteria	2|Bacteria	EGP	Transmembrane secretion effector	bacE	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
SX2_k127_1532198_6	384616.Pisl_1828	7.001e-10	68.0	COG0350@1|root,arCOG02724@2157|Archaea,2XR5F@28889|Crenarchaeota	28889|Crenarchaeota	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1
SX2_k127_1532198_1	744872.Spica_0292	4.459e-68	246.0	COG5522@1|root,COG5522@2|Bacteria	2|Bacteria	S	Integral membrane protein (intg_mem_TP0381)	ywaF	-	-	-	-	-	-	-	-	-	-	-	Intg_mem_TP0381
SX2_k127_1532198_0	1392838.AWNM01000078_gene1122	7.915e-171	590.0	COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	4HB_MCP_1,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3
SX2_k127_1532198_2	56780.SYN_00971	4.607e-58	232.0	COG0840@1|root,COG4191@1|root,COG0840@2|Bacteria,COG4191@2|Bacteria,1MU9B@1224|Proteobacteria,42N03@68525|delta/epsilon subdivisions,2WIX4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NT	PFAM chemotaxis sensory transducer	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,MCPsignal,dCache_1
SX2_k127_1532198_3	93220.LV28_11815	9.79e-42	177.0	COG0840@1|root,COG2202@1|root,COG0840@2|Bacteria,COG2202@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,1K29X@119060|Burkholderiaceae	28216|Betaproteobacteria	T	chemotaxis protein	mcpA	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,PAS_3,TarH
SX2_k127_1532198_4	1173028.ANKO01000020_gene5515	1.037e-37	157.0	COG2114@1|root,COG2203@1|root,COG3437@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,COG3437@2|Bacteria,1FZXP@1117|Cyanobacteria,1H71W@1150|Oscillatoriales	1117|Cyanobacteria	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	-	-	-	-	-	-	-	-	-	-	-	-	GAF,Guanylate_cyc,PAS_3,PAS_4,Response_reg
SX2_k127_1542360_2	1128421.JAGA01000002_gene1483	4.136e-91	321.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_106
SX2_k127_1542360_9	596324.TREVI0001_0494	4.702e-35	147.0	COG2199@1|root,COG3706@2|Bacteria,2J5S2@203691|Spirochaetes	203691|Spirochaetes	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,cNMP_binding
SX2_k127_1542360_7	243275.TDE_2725	5.044e-50	205.0	COG2199@1|root,COG3706@2|Bacteria,2J6RG@203691|Spirochaetes	203691|Spirochaetes	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,cNMP_binding
SX2_k127_1542360_3	545695.TREAZ_3287	3.501e-86	320.0	COG0618@1|root,COG0618@2|Bacteria,2J6ZI@203691|Spirochaetes	203691|Spirochaetes	S	DHH family	-	-	-	-	-	-	-	-	-	-	-	-	DHH
SX2_k127_1542360_8	660470.Theba_2631	1.167e-45	177.0	28N6F@1|root,30YAD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1542360_11	2423.NA23_0209490	2.796e-27	118.0	arCOG03622@1|root,33HZF@2|Bacteria,2GE37@200918|Thermotogae	200918|Thermotogae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1542360_10	1266845.Q783_08795	2.67e-31	133.0	2E9V0@1|root,3340V@2|Bacteria,1V6HR@1239|Firmicutes,4HIXZ@91061|Bacilli,27GRI@186828|Carnobacteriaceae	91061|Bacilli	M	carotenoid biosynthetic process	-	-	-	ko:K10212	ko00906,map00906	-	R07656	RC00041	ko00000,ko00001,ko01000	-	-	-	-
SX2_k127_1542360_1	545697.HMPREF0216_00098	9.523e-137	464.0	COG1233@1|root,COG1233@2|Bacteria,1TS4A@1239|Firmicutes,249K1@186801|Clostridia,36EIK@31979|Clostridiaceae	186801|Clostridia	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
SX2_k127_1542360_4	765913.ThidrDRAFT_3034	1.423e-83	294.0	COG1215@1|root,COG1215@2|Bacteria,1MW1E@1224|Proteobacteria,1SAEV@1236|Gammaproteobacteria,1WZQW@135613|Chromatiales	135613|Chromatiales	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SX2_k127_1542360_5	247634.GPB2148_1377	1.08e-58	222.0	COG4221@1|root,COG4221@2|Bacteria,1RF5D@1224|Proteobacteria,1S5AC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SX2_k127_1542360_6	1122176.KB903609_gene5261	7.451e-51	192.0	COG1030@1|root,COG1030@2|Bacteria,4PN0T@976|Bacteroidetes,1ITG9@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TspO_MBR
SX2_k127_1542360_0	889378.Spiaf_2634	2.111e-155	500.0	COG0326@1|root,COG0326@2|Bacteria,2J6JQ@203691|Spirochaetes	203691|Spirochaetes	F	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c_3,HSP90
SX2_k127_1544073_4	1265505.ATUG01000002_gene2637	1.738e-25	106.0	29CZA@1|root,2ZZXB@2|Bacteria,1RFNE@1224|Proteobacteria,42TRV@68525|delta/epsilon subdivisions,2WR3X@28221|Deltaproteobacteria,2MKTT@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1544073_0	1254432.SCE1572_47310	1.41e-99	340.0	COG1475@1|root,COG1475@2|Bacteria,1Q2AH@1224|Proteobacteria,437X8@68525|delta/epsilon subdivisions,2X9QN@28221|Deltaproteobacteria,2YUMN@29|Myxococcales	28221|Deltaproteobacteria	K	ParB-like nuclease domain	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
SX2_k127_1544073_2	1499967.BAYZ01000104_gene3649	9.32e-52	201.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX2_k127_1544073_1	1380394.JADL01000008_gene3482	8.196e-52	190.0	COG1175@1|root,COG1175@2|Bacteria,1MVAP@1224|Proteobacteria,2TSNP@28211|Alphaproteobacteria,2JTR7@204441|Rhodospirillales	204441|Rhodospirillales	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
SX2_k127_1550797_1	754027.HMPREF9554_02807	1.591e-79	274.0	COG0094@1|root,COG0094@2|Bacteria,2J5DT@203691|Spirochaetes	203691|Spirochaetes	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
SX2_k127_1550797_4	877418.ATWV01000004_gene1915	1.436e-27	115.0	COG0198@1|root,COG0198@2|Bacteria,2J809@203691|Spirochaetes	203691|Spirochaetes	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
SX2_k127_1550797_3	744872.Spica_0395	3.572e-61	213.0	COG0093@1|root,COG0093@2|Bacteria,2J7N1@203691|Spirochaetes	203691|Spirochaetes	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
SX2_k127_1550797_5	573413.Spirs_0964	1.655e-26	111.0	COG0186@1|root,COG0186@2|Bacteria,2J8JX@203691|Spirochaetes	203691|Spirochaetes	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
SX2_k127_1550797_6	744872.Spica_0393	1.854e-13	73.0	COG0255@1|root,COG0255@2|Bacteria,2J8R5@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
SX2_k127_1550797_2	744872.Spica_0392	3.404e-62	216.0	COG0197@1|root,COG0197@2|Bacteria,2J7H3@203691|Spirochaetes	203691|Spirochaetes	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
SX2_k127_1550797_0	744872.Spica_0391	4.802e-95	317.0	COG0092@1|root,COG0092@2|Bacteria,2J5AK@203691|Spirochaetes	203691|Spirochaetes	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
SX2_k127_1551433_1	1123274.KB899414_gene3665	1.709e-119	392.0	COG2204@1|root,COG2204@2|Bacteria,2J63G@203691|Spirochaetes	203691|Spirochaetes	T	Regulatory protein	-	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
SX2_k127_1551433_0	889378.Spiaf_2666	6.062e-123	423.0	COG5000@1|root,COG5000@2|Bacteria,2J753@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase	ntrY	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
SX2_k127_1551433_3	665571.STHERM_c21970	4.484e-31	123.0	COG1925@1|root,COG1925@2|Bacteria,2J8AV@203691|Spirochaetes	203691|Spirochaetes	G	phosphocarrier protein HPr	-	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
SX2_k127_1551433_2	1437425.CSEC_0703	6.297e-70	244.0	COG1493@1|root,COG1493@2|Bacteria,2JFSZ@204428|Chlamydiae	204428|Chlamydiae	H	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
SX2_k127_1552716_4	573413.Spirs_2149	6.833e-70	241.0	COG0664@1|root,COG0664@2|Bacteria,2J5G6@203691|Spirochaetes	203691|Spirochaetes	T	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
SX2_k127_1552716_1	1340493.JNIF01000003_gene2296	7.812e-107	377.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	ko:K18106	ko00040,ko01100,map00040,map01100	M00630	R07676,R10565	RC00108	ko00000,ko00001,ko00002,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX2_k127_1552716_6	1089551.KE386572_gene3795	2.388e-53	210.0	COG1940@1|root,COG1940@2|Bacteria,1RBY5@1224|Proteobacteria,2U5ZX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	ROK
SX2_k127_1552716_0	497964.CfE428DRAFT_1536	2.793e-142	467.0	COG0160@1|root,COG0160@2|Bacteria,46UEH@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Aminotransferase class-III	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
SX2_k127_1552716_8	665571.STHERM_c20830	5.221e-46	173.0	COG0494@1|root,COG0494@2|Bacteria,2J7P7@203691|Spirochaetes	203691|Spirochaetes	L	Belongs to the Nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
SX2_k127_1552716_10	926550.CLDAP_07570	1.107e-07	64.0	COG0392@1|root,COG0392@2|Bacteria,2G96G@200795|Chloroflexi	200795|Chloroflexi	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
SX2_k127_1552716_7	877455.Metbo_0249	2.803e-48	186.0	COG0463@1|root,arCOG01385@2157|Archaea,2XVTU@28890|Euryarchaeota,23NU6@183925|Methanobacteria	183925|Methanobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_3,Glycos_transf_2
SX2_k127_1552716_9	1232443.BAIA02000147_gene1621	4.58e-43	168.0	COG1402@1|root,COG1402@2|Bacteria,1V0N8@1239|Firmicutes,24R48@186801|Clostridia	186801|Clostridia	S	Creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
SX2_k127_1552716_3	926550.CLDAP_35620	2.056e-74	265.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	ko:K02025,ko:K05814,ko:K10118,ko:K10237,ko:K10241,ko:K15771,ko:K17235,ko:K17242,ko:K17316	ko02010,map02010	M00196,M00198,M00204,M00206,M00207,M00491,M00600,M00602,M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.17,3.A.1.1.2,3.A.1.1.23,3.A.1.1.24,3.A.1.1.28,3.A.1.1.3,3.A.1.1.30,3.A.1.1.34,3.A.1.1.39	-	-	BPD_transp_1
SX2_k127_1552716_2	926550.CLDAP_35610	1.875e-79	274.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	malF	-	-	ko:K02026,ko:K05815	ko02010,map02010	M00198,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.3	-	-	BPD_transp_1
SX2_k127_1552716_5	649638.Trad_2282	2.023e-64	231.0	COG1653@1|root,COG1653@2|Bacteria,1WIUT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K02027,ko:K05813	ko02010,map02010	M00198,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.3	-	-	SBP_bac_8
SX2_k127_1556488_1	1123274.KB899415_gene2445	9.258e-65	241.0	COG0760@1|root,COG0760@2|Bacteria,2J720@203691|Spirochaetes	203691|Spirochaetes	O	PFAM PPIC-type PPIASE domain	-	-	-	-	-	-	-	-	-	-	-	-	Rotamase,Rotamase_2,SurA_N_2,SurA_N_3
SX2_k127_1556488_2	573413.Spirs_1829	3.7e-38	164.0	COG2604@1|root,COG2604@2|Bacteria,2J5F2@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF115	-	-	-	-	-	-	-	-	-	-	-	-	MAF_flag10
SX2_k127_1556488_0	744872.Spica_0806	9.952e-291	902.0	COG0481@1|root,COG0481@2|Bacteria,2J5V8@203691|Spirochaetes	203691|Spirochaetes	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
SX2_k127_1562645_0	744872.Spica_1343	6.304e-79	270.0	COG0809@1|root,COG0809@2|Bacteria,2J5HY@203691|Spirochaetes	203691|Spirochaetes	H	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
SX2_k127_1562645_1	665571.STHERM_c11280	1.914e-67	243.0	2C2MH@1|root,33D2Y@2|Bacteria,2J70Q@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1562645_2	1307761.L21SP2_1824	1.426e-52	192.0	COG0125@1|root,COG0125@2|Bacteria,2J765@203691|Spirochaetes	203691|Spirochaetes	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
SX2_k127_1562645_3	671143.DAMO_1913	3.423e-24	109.0	COG0811@1|root,COG0811@2|Bacteria,2NPUZ@2323|unclassified Bacteria	2|Bacteria	U	MotA/TolQ/ExbB proton channel family	exbB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0017038,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
SX2_k127_1562645_4	1121413.JMKT01000014_gene2543	9.395e-07	59.0	COG0848@1|root,COG0848@2|Bacteria,1RI4M@1224|Proteobacteria,42SKN@68525|delta/epsilon subdivisions,2WNIQ@28221|Deltaproteobacteria,2MBS5@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
SX2_k127_1571339_5	1349822.NSB1T_13220	8.154e-41	157.0	COG0540@1|root,COG0540@2|Bacteria,4NFIU@976|Bacteroidetes,2FN60@200643|Bacteroidia,22W4C@171551|Porphyromonadaceae	976|Bacteroidetes	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
SX2_k127_1571339_6	1337093.MBE-LCI_1796	6.17e-34	141.0	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,2TSBK@28211|Alphaproteobacteria,2P801@245186|Loktanella	28211|Alphaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluD	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
SX2_k127_1571339_4	1307761.L21SP2_0152	8.236e-51	200.0	2BN9R@1|root,32GX8@2|Bacteria,2JAW7@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1571339_3	1128421.JAGA01000003_gene3256	1.56e-57	223.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4080,Radical_SAM
SX2_k127_1571339_7	429009.Adeg_0709	1.585e-32	138.0	COG1533@1|root,COG1533@2|Bacteria	2|Bacteria	L	DNA photolyase activity	splB	GO:0003674,GO:0003824,GO:0003913,GO:0005488,GO:0005575,GO:0005623,GO:0016829,GO:0016830,GO:0042601,GO:0042763,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0070283,GO:0140097	4.1.99.14	ko:K03716	-	-	-	-	ko00000,ko01000	-	-	-	-
SX2_k127_1571339_2	1125700.HMPREF9195_01931	9.101e-60	216.0	COG0761@1|root,COG0761@2|Bacteria,2J56Z@203691|Spirochaetes	203691|Spirochaetes	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
SX2_k127_1571339_1	665571.STHERM_c17140	4.114e-60	221.0	COG0142@1|root,COG0142@2|Bacteria	2|Bacteria	H	isoprenoid biosynthetic process	idsA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
SX2_k127_1571339_0	545694.TREPR_1176	1.143e-186	593.0	COG0282@1|root,COG0282@2|Bacteria,2J57M@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
SX2_k127_1589213_1	935948.KE386494_gene488	8.462e-168	543.0	COG1653@1|root,COG1653@2|Bacteria,1U4VB@1239|Firmicutes,24AYM@186801|Clostridia,42HSF@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM extracellular solute-binding protein family 1	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_1,SBP_bac_8
SX2_k127_1589213_5	324602.Caur_0357	8.44e-38	158.0	COG0204@1|root,COG0204@2|Bacteria,2G92W@200795|Chloroflexi,3779N@32061|Chloroflexia	32061|Chloroflexia	I	PFAM phospholipid glycerol acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
SX2_k127_1589213_2	1521187.JPIM01000001_gene834	4.781e-92	317.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	yghO	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SX2_k127_1589213_0	1499967.BAYZ01000118_gene3277	2.321e-216	681.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C
SX2_k127_1589213_3	1304880.JAGB01000001_gene865	4.707e-85	303.0	COG0673@1|root,COG0673@2|Bacteria,1UIIC@1239|Firmicutes,249KE@186801|Clostridia	186801|Clostridia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
SX2_k127_1589213_6	1089551.KE386572_gene1634	1.675e-36	155.0	COG5598@1|root,COG5598@2|Bacteria,1N18H@1224|Proteobacteria,2TRUE@28211|Alphaproteobacteria,4BRNZ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Trimethylamine methyltransferase (MTTB)	mttB2	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
SX2_k127_1589213_4	857293.CAAU_2183	3.902e-60	224.0	COG0683@1|root,COG0683@2|Bacteria,1TPQ2@1239|Firmicutes,248H1@186801|Clostridia,36DTA@31979|Clostridiaceae	186801|Clostridia	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
SX2_k127_1598865_1	177439.DP1964	5.513e-35	154.0	COG1470@1|root,COG4932@1|root,COG1470@2|Bacteria,COG4932@2|Bacteria,1R7QK@1224|Proteobacteria,42Z8R@68525|delta/epsilon subdivisions,2WTWG@28221|Deltaproteobacteria,2MMY9@213118|Desulfobacterales	28221|Deltaproteobacteria	M	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1598865_0	744872.Spica_1477	1.033e-180	595.0	COG1643@1|root,COG1643@2|Bacteria,2J62C@203691|Spirochaetes	203691|Spirochaetes	L	ATP-dependent helicase HrpB	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
SX2_k127_1598865_2	543734.LCABL_25000	0.0003144	52.0	COG0640@1|root,COG0640@2|Bacteria,1VIR8@1239|Firmicutes,4HPZ0@91061|Bacilli	91061|Bacilli	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
SX2_k127_1606817_1	580340.Tlie_0372	5.897e-145	471.0	COG1228@1|root,COG1228@2|Bacteria,3T9W4@508458|Synergistetes	508458|Synergistetes	Q	PFAM amidohydrolase	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
SX2_k127_1606817_3	1499967.BAYZ01000152_gene1402	9.244e-24	117.0	COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,2NNXZ@2323|unclassified Bacteria	2|Bacteria	E	Formiminotransferase-cyclodeaminase	ftcD	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K01746,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_C,FTCD_N
SX2_k127_1606817_0	335543.Sfum_2378	6.27e-210	677.0	COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,42MST@68525|delta/epsilon subdivisions,2WKAN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
SX2_k127_1606817_2	555779.Dthio_PD0015	1.953e-24	108.0	COG1569@1|root,COG1569@2|Bacteria,1Q9X7@1224|Proteobacteria,42X9V@68525|delta/epsilon subdivisions,2WT2V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
SX2_k127_1607957_7	744872.Spica_1657	2.253e-65	235.0	COG0849@1|root,COG0849@2|Bacteria,2J7C9@203691|Spirochaetes	203691|Spirochaetes	D	MutL protein	-	-	-	-	-	-	-	-	-	-	-	-	MutL
SX2_k127_1607957_0	744872.Spica_1658	1.679e-204	662.0	COG4865@1|root,COG4865@2|Bacteria,2J6PW@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the carbon skeleton rearrangement of L- glutamate to L-threo-3-methylaspartate ((2S,3S)-3- methylaspartate)	glmE	-	5.4.99.1	ko:K19268	ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200	M00740	R00262	RC01221	ko00000,ko00001,ko00002,ko01000	-	-	-	Met_asp_mut_E
SX2_k127_1607957_2	744872.Spica_1659	1.723e-160	544.0	COG3799@1|root,COG3799@2|Bacteria,2J78A@203691|Spirochaetes	203691|Spirochaetes	H	Methylaspartate ammonia-lyase	-	-	4.3.1.2	ko:K04835	ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200	M00740	R03696	RC00979	ko00000,ko00001,ko00002,ko01000	-	-	-	MAAL_C,MAAL_N
SX2_k127_1607957_1	744872.Spica_1660	1.077e-184	610.0	COG1574@1|root,COG1574@2|Bacteria,2J6CH@203691|Spirochaetes	203691|Spirochaetes	S	Pfam:DUF1446	-	-	-	-	-	-	-	-	-	-	-	-	AtuA
SX2_k127_1607957_10	744872.Spica_1661	2.129e-30	138.0	2CDKX@1|root,32RXZ@2|Bacteria,2J91F@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF4387)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4387
SX2_k127_1607957_6	744872.Spica_1191	3.112e-67	233.0	COG2872@1|root,COG2872@2|Bacteria	2|Bacteria	S	Ser-tRNA(Ala) hydrolase activity	alaXM	GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872,ko:K07050	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
SX2_k127_1607957_8	744872.Spica_1191	1.093e-53	192.0	COG2872@1|root,COG2872@2|Bacteria	2|Bacteria	S	Ser-tRNA(Ala) hydrolase activity	alaXM	GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872,ko:K07050	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
SX2_k127_1607957_4	1123508.JH636439_gene1315	1.879e-124	441.0	COG4191@1|root,COG4191@2|Bacteria,2J2PC@203682|Planctomycetes	203682|Planctomycetes	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,Response_reg
SX2_k127_1607957_5	1122915.AUGY01000069_gene2954	4.63e-107	370.0	COG2972@1|root,COG2972@2|Bacteria,1V051@1239|Firmicutes,4HHCW@91061|Bacilli,26TRX@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase,dCache_1
SX2_k127_1607957_3	1227352.C173_25841	6.598e-155	524.0	COG0665@1|root,COG0665@2|Bacteria,1VRH3@1239|Firmicutes,4ISQR@91061|Bacilli,26SF8@186822|Paenibacillaceae	91061|Bacilli	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
SX2_k127_1607957_9	439292.Bsel_0415	2.191e-52	191.0	COG0395@1|root,COG0395@2|Bacteria,1UXJT@1239|Firmicutes,4HUDY@91061|Bacilli,26PTF@186821|Sporolactobacillaceae	91061|Bacilli	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026,ko:K10190,ko:K17236	ko02010,map02010	M00199,M00207,M00602	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.34,3.A.1.1.4	-	-	BPD_transp_1
SX2_k127_1610183_0	644966.Tmar_1316	5.96e-75	265.0	COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,24XN8@186801|Clostridia,3WCVP@538999|Clostridiales incertae sedis	186801|Clostridia	S	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
SX2_k127_1610183_1	324057.Pjdr2_3321	1.403e-69	254.0	COG4603@1|root,COG4603@2|Bacteria,1TP1F@1239|Firmicutes,4H9VE@91061|Bacilli,26QBG@186822|Paenibacillaceae	91061|Bacilli	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
SX2_k127_1610183_2	891968.Anamo_2053	6.465e-66	248.0	COG1079@1|root,COG1079@2|Bacteria,3TAFP@508458|Synergistetes	508458|Synergistetes	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
SX2_k127_1610634_3	1283284.AZUK01000001_gene284	7.204e-89	301.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,1RPGK@1236|Gammaproteobacteria,1Y61V@135624|Aeromonadales	135624|Aeromonadales	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
SX2_k127_1610634_4	1304865.JAGF01000001_gene1578	2.694e-81	311.0	28PJ3@1|root,2ZC8W@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1610634_0	243231.GSU2758	0.0	2445.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42P3V@68525|delta/epsilon subdivisions,2WKWV@28221|Deltaproteobacteria,43TF0@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA1	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
SX2_k127_1610634_2	926569.ANT_12070	2.438e-117	394.0	COG0477@1|root,COG2814@2|Bacteria,2G5ZW@200795|Chloroflexi	200795|Chloroflexi	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX2_k127_1610634_1	661478.OP10G_3758	2.008e-197	626.0	COG3534@1|root,COG3534@2|Bacteria	2|Bacteria	G	alpha-L-arabinofuranosidase	abfA	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
SX2_k127_1610634_5	429009.Adeg_1136	1.94e-55	206.0	COG0595@1|root,COG0595@2|Bacteria,1V0AV@1239|Firmicutes,24AT4@186801|Clostridia,42EKF@68295|Thermoanaerobacterales	186801|Clostridia	S	RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B_2,RMMBL
SX2_k127_1613691_2	665571.STHERM_c01120	3.22e-41	170.0	2C0A1@1|root,33WBM@2|Bacteria,2J8WC@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1613691_1	744872.Spica_1000	2.543e-150	494.0	COG2114@1|root,COG2114@2|Bacteria,2J6Q9@203691|Spirochaetes	203691|Spirochaetes	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP,Response_reg
SX2_k127_1613691_0	452637.Oter_4352	2.226e-169	539.0	COG4868@1|root,COG4868@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF1846)	XK27_07020	-	-	-	-	-	-	-	-	-	-	-	DUF1846
SX2_k127_1613734_2	304371.MCP_0596	6.053e-29	118.0	COG0535@1|root,arCOG00940@2157|Archaea,2XV7M@28890|Euryarchaeota,2N94R@224756|Methanomicrobia	224756|Methanomicrobia	S	Radical SAM domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM
SX2_k127_1613734_1	1123288.SOV_1c02640	5.797e-32	138.0	COG0454@1|root,COG0456@2|Bacteria,1V4GU@1239|Firmicutes,4H7Q3@909932|Negativicutes	909932|Negativicutes	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1613734_0	563192.HMPREF0179_01009	1.434e-41	167.0	COG2606@1|root,COG2606@2|Bacteria,1RGX5@1224|Proteobacteria,42T6B@68525|delta/epsilon subdivisions,2WPVS@28221|Deltaproteobacteria,2MGG2@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Aminoacyl-tRNA editing domain	ybaK	-	-	ko:K03976	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
SX2_k127_1614199_3	935948.KE386494_gene356	8.004e-110	364.0	COG2768@1|root,COG2768@2|Bacteria,1TQAW@1239|Firmicutes,247IS@186801|Clostridia,42ETU@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4,Fer4_21
SX2_k127_1614199_4	1168034.FH5T_11665	2.994e-70	271.0	COG5505@1|root,COG5505@2|Bacteria,4NPE1@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function (DUF819)	-	-	-	-	-	-	-	-	-	-	-	-	DUF819
SX2_k127_1614199_1	1434325.AZQN01000006_gene3304	2.611e-149	503.0	COG0546@1|root,COG2870@1|root,COG0546@2|Bacteria,COG2870@2|Bacteria,4NJ8F@976|Bacteroidetes,47MRA@768503|Cytophagia	976|Bacteroidetes	M	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase,PfkB
SX2_k127_1614199_2	313628.LNTAR_18720	1.254e-120	400.0	COG1915@1|root,COG1915@2|Bacteria	2|Bacteria	E	PFAM LOR SDH bifunctional enzyme conserved region	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1614199_0	665571.STHERM_c16630	0.0	1212.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,2J5QV@203691|Spirochaetes	203691|Spirochaetes	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K00169,ko:K03737	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034,R10866	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
SX2_k127_1614881_2	378806.STAUR_0928	5.677e-10	65.0	2CCQF@1|root,2Z7QP@2|Bacteria,1NQ0V@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1614881_0	903818.KI912268_gene2682	4.227e-141	458.0	COG1897@1|root,COG1897@2|Bacteria,3Y6RE@57723|Acidobacteria	57723|Acidobacteria	E	Homoserine O-succinyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	HTS
SX2_k127_1614881_1	1005999.GLGR_3548	1.12e-48	177.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,1S087@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
SX2_k127_1619991_3	1121346.KB899813_gene2159	2.002e-33	130.0	COG1175@1|root,COG1175@2|Bacteria,1TPTZ@1239|Firmicutes,4HB63@91061|Bacilli,26S91@186822|Paenibacillaceae	91061|Bacilli	G	ABC transporter permease	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
SX2_k127_1619991_0	357808.RoseRS_1358	7.295e-75	261.0	COG0395@1|root,COG0395@2|Bacteria,2G7M8@200795|Chloroflexi,37780@32061|Chloroflexia	32061|Chloroflexia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX2_k127_1619991_2	521045.Kole_0693	4.511e-43	174.0	COG1653@1|root,COG1653@2|Bacteria,2GCPM@200918|Thermotogae	200918|Thermotogae	G	Extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
SX2_k127_1619991_1	1423321.AS29_20880	1.179e-70	270.0	COG5434@1|root,COG5434@2|Bacteria,1UHQG@1239|Firmicutes,4HI8W@91061|Bacilli,1ZSFJ@1386|Bacillus	91061|Bacilli	M	Heparinase II/III N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Hepar_II_III,Hepar_II_III_N
SX2_k127_16227_2	886293.Sinac_0260	5.606e-84	287.0	COG1070@1|root,COG1070@2|Bacteria,2IXYW@203682|Planctomycetes	203682|Planctomycetes	G	COG1070 Sugar (pentulose and hexulose)	-	-	2.7.1.5	ko:K00848	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01902,R03014	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
SX2_k127_16227_1	1304885.AUEY01000007_gene1357	1.02e-113	406.0	COG2202@1|root,COG2905@1|root,COG4564@1|root,COG2202@2|Bacteria,COG2905@2|Bacteria,COG4564@2|Bacteria,1MW8U@1224|Proteobacteria,42NAX@68525|delta/epsilon subdivisions,2WJF5@28221|Deltaproteobacteria,2MIA9@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Putative nucleotidyltransferase substrate binding domain	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,PAS_8,cNMP_binding,sCache_2
SX2_k127_16227_4	1387312.BAUS01000002_gene548	5.335e-15	90.0	COG0613@1|root,COG0613@2|Bacteria,1MWIH@1224|Proteobacteria,2VHB2@28216|Betaproteobacteria,2KKKK@206350|Nitrosomonadales	206350|Nitrosomonadales	S	PFAM PHP domain	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
SX2_k127_16227_3	1121396.KB893012_gene4099	4.189e-17	87.0	COG3162@1|root,COG3162@2|Bacteria,1NB5T@1224|Proteobacteria,42VP8@68525|delta/epsilon subdivisions,2WSCP@28221|Deltaproteobacteria,2MNWK@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function, DUF485	-	-	-	-	-	-	-	-	-	-	-	-	DUF485
SX2_k127_16227_0	1232410.KI421416_gene2649	1.668e-219	704.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,42MJE@68525|delta/epsilon subdivisions,2WK5T@28221|Deltaproteobacteria,43TCV@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	aplA	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	iAF987.Gmet_0739	SSF
SX2_k127_16227_6	665571.STHERM_c22260	9.442e-12	73.0	COG3712@1|root,COG3712@2|Bacteria	2|Bacteria	PT	iron ion homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	DUF389,FecR
SX2_k127_1623611_0	926560.KE387027_gene866	1.336e-145	480.0	COG3345@1|root,COG3345@2|Bacteria,1WIV5@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Melibiase	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Melibiase
SX2_k127_1623611_5	1541065.JRFE01000012_gene2488	2.127e-18	95.0	COG3437@1|root,COG5002@1|root,COG3437@2|Bacteria,COG5002@2|Bacteria,1FZYQ@1117|Cyanobacteria,3VIWA@52604|Pleurocapsales	1117|Cyanobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
SX2_k127_1623611_2	555779.Dthio_PD1992	3.922e-45	169.0	COG3742@1|root,COG3742@2|Bacteria,1Q9V8@1224|Proteobacteria,432KI@68525|delta/epsilon subdivisions,2WXAS@28221|Deltaproteobacteria,2MFTK@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
SX2_k127_1623611_6	555779.Dthio_PD1991	1.319e-16	82.0	COG4423@1|root,COG4423@2|Bacteria,1NDG1@1224|Proteobacteria	1224|Proteobacteria	S	Transcription factor	-	-	-	ko:K19687	-	-	-	-	ko00000,ko02048	-	-	-	PSK_trans_fac
SX2_k127_1623611_1	909663.KI867150_gene2881	1.477e-105	367.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42QJF@68525|delta/epsilon subdivisions,2WJ9D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,Response_reg
SX2_k127_1623611_7	909663.KI867150_gene2880	3.124e-15	86.0	COG0745@1|root,COG0745@2|Bacteria,1PGXZ@1224|Proteobacteria,437JJ@68525|delta/epsilon subdivisions,2X2TK@28221|Deltaproteobacteria,2MSE0@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
SX2_k127_1623611_4	1499967.BAYZ01000059_gene4769	1.299e-21	106.0	COG0745@1|root,COG0745@2|Bacteria,2NRCE@2323|unclassified Bacteria	2|Bacteria	KT	cheY-homologous receiver domain	-	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
SX2_k127_1623611_3	1125863.JAFN01000001_gene1558	3.887e-41	158.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42N5C@68525|delta/epsilon subdivisions,2WM18@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_9,Response_reg
SX2_k127_1627806_1	697281.Mahau_1153	3.371e-25	108.0	COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24805@186801|Clostridia,42FFC@68295|Thermoanaerobacterales	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,RnfC_N,SLBB
SX2_k127_1627806_2	1250232.JQNJ01000001_gene2685	2.662e-16	86.0	COG0454@1|root,COG0456@2|Bacteria,4NUI2@976|Bacteroidetes,1I4HH@117743|Flavobacteriia	976|Bacteroidetes	K	GCN5 family acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SX2_k127_1627806_0	1173020.Cha6605_5177	4.328e-48	176.0	COG1752@1|root,COG1752@2|Bacteria,1GC5D@1117|Cyanobacteria	1117|Cyanobacteria	S	Esterase of the alpha-beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1636914_4	744872.Spica_2496	5.84e-29	119.0	COG0607@1|root,COG0607@2|Bacteria,2J8B4@203691|Spirochaetes	203691|Spirochaetes	P	Rhodanese Homology Domain	glpE	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
SX2_k127_1636914_0	1379270.AUXF01000004_gene2893	3.123e-226	717.0	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1ZV6A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
SX2_k127_1636914_3	1121289.JHVL01000004_gene2118	2.703e-30	125.0	COG4869@1|root,COG4869@2|Bacteria,1V242@1239|Firmicutes,24816@186801|Clostridia,36E22@31979|Clostridiaceae	186801|Clostridia	Q	Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate	pduL	-	2.3.1.8	ko:K15024	ko00430,ko00620,ko00640,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00720,map01100,map01120,map01200	M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans,PTAC
SX2_k127_1636914_1	177437.HRM2_06340	6.637e-109	368.0	COG1079@1|root,COG1079@2|Bacteria,1MVDQ@1224|Proteobacteria,42P6E@68525|delta/epsilon subdivisions,2WISH@28221|Deltaproteobacteria,2MHMZ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
SX2_k127_1636914_2	177437.HRM2_06330	4.353e-94	316.0	COG4603@1|root,COG4603@2|Bacteria,1MX6V@1224|Proteobacteria,42QQQ@68525|delta/epsilon subdivisions,2WMBP@28221|Deltaproteobacteria,2MIM7@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
SX2_k127_1637743_0	234267.Acid_4491	4.72e-211	668.0	COG0653@1|root,COG0653@2|Bacteria,3Y34P@57723|Acidobacteria	57723|Acidobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
SX2_k127_1640195_4	697281.Mahau_0316	2.452e-37	143.0	COG0334@1|root,COG0334@2|Bacteria,1TP45@1239|Firmicutes,24960@186801|Clostridia,42FA1@68295|Thermoanaerobacterales	186801|Clostridia	C	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.2,1.4.1.3,1.4.1.4	ko:K00260,ko:K00261,ko:K00262	ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
SX2_k127_1640195_3	1449126.JQKL01000016_gene2859	6.562e-51	196.0	COG2267@1|root,COG2267@2|Bacteria,1TRM1@1239|Firmicutes,247J5@186801|Clostridia	186801|Clostridia	I	Hydrolase, alpha beta domain protein	-	-	3.1.1.5	ko:K01048	ko00564,map00564	-	-	-	ko00000,ko00001,ko01000	-	-	-	Hydrolase_4
SX2_k127_1640195_1	926569.ANT_29670	3.274e-194	623.0	COG1132@1|root,COG1132@2|Bacteria,2G5QH@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SX2_k127_1640195_0	926569.ANT_29680	4.194e-202	672.0	COG1132@1|root,COG1132@2|Bacteria,2G66A@200795|Chloroflexi	200795|Chloroflexi	V	ABC transporter, transmembrane region	-	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SX2_k127_1640195_2	1123229.AUBC01000029_gene3528	9.907e-53	190.0	COG2313@1|root,COG2313@2|Bacteria,1MUQU@1224|Proteobacteria,2TUKT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway	psuG	-	4.2.1.70	ko:K16329	ko00240,map00240	-	R01055	RC00432,RC00433	ko00000,ko00001,ko01000	-	-	-	Indigoidine_A
SX2_k127_1641221_5	158189.SpiBuddy_1548	2e-07	52.0	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,2J5NQ@203691|Spirochaetes	203691|Spirochaetes	C	pyridine nucleotide-disulphide oxidoreductase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,Rhodanese
SX2_k127_1641221_0	545695.TREAZ_2760	1.05e-170	547.0	28MXM@1|root,2Z8AT@2|Bacteria,2JBFX@203691|Spirochaetes	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1641221_3	1123373.ATXI01000003_gene1378	2.571e-18	95.0	COG3103@1|root,COG4991@2|Bacteria,2GHRI@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	sh3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1641221_4	573413.Spirs_3350	4.648e-15	83.0	28X9U@1|root,2ZJ7V@2|Bacteria,2J87S@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1641221_1	1123274.KB899411_gene3193	4.788e-71	243.0	COG2236@1|root,COG2236@2|Bacteria,2JAE0@203691|Spirochaetes	203691|Spirochaetes	F	PFAM Phosphoribosyl transferase domain	-	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
SX2_k127_1649653_1	338963.Pcar_2044	2.937e-113	370.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,42MA4@68525|delta/epsilon subdivisions,2WIPU@28221|Deltaproteobacteria,43S7P@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Enoyl-(Acyl carrier protein) reductase	fabI	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SX2_k127_1649653_2	1123252.ATZF01000031_gene1917	9.135e-40	166.0	COG1296@1|root,COG1296@2|Bacteria,1TSXD@1239|Firmicutes,4I4E6@91061|Bacilli,27C5I@186824|Thermoactinomycetaceae	91061|Bacilli	E	AzlC protein	-	-	-	-	-	-	-	-	-	-	-	-	AzlC
SX2_k127_1649653_4	1121936.AUHI01000007_gene2392	5.798e-15	86.0	COG4392@1|root,COG4392@2|Bacteria,1VBUN@1239|Firmicutes,4HKJZ@91061|Bacilli	91061|Bacilli	S	Branched-chain amino acid transport protein (AzlD)	-	-	-	-	-	-	-	-	-	-	-	-	AzlD
SX2_k127_1649653_3	1499967.BAYZ01000151_gene1664	4.096e-18	89.0	COG0599@1|root,COG0599@2|Bacteria	2|Bacteria	S	peroxiredoxin activity	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
SX2_k127_1649653_0	96561.Dole_2961	2.624e-116	384.0	COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,42MK9@68525|delta/epsilon subdivisions,2WJ1C@28221|Deltaproteobacteria,2MIP5@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM PhoH-like protein	phoH1	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
SX2_k127_1649692_0	665571.STHERM_c15920	2.087e-263	818.0	COG0060@1|root,COG0060@2|Bacteria,2J57V@203691|Spirochaetes	203691|Spirochaetes	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
SX2_k127_1649692_1	1123274.KB899415_gene2416	8.751e-207	659.0	COG0018@1|root,COG0018@2|Bacteria,2J5EP@203691|Spirochaetes	203691|Spirochaetes	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
SX2_k127_1656753_0	1499967.BAYZ01000013_gene6421	8.318e-174	556.0	COG1012@1|root,COG1012@2|Bacteria,2NQI9@2323|unclassified Bacteria	2|Bacteria	C	Aldehyde dehydrogenase family	eutE	GO:0003674,GO:0003824,GO:0004029,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.87	ko:K04021,ko:K13922	ko00620,ko00640,ko01100,ko01120,map00620,map00640,map01100,map01120	-	R00228,R09097	RC00004,RC00184,RC01195	ko00000,ko00001,ko01000	-	-	-	Aldedh
SX2_k127_1656753_3	1499967.BAYZ01000013_gene6422	2.86e-23	101.0	COG4576@1|root,COG4576@2|Bacteria,2NRYU@2323|unclassified Bacteria	2|Bacteria	CQ	Ethanolamine utilisation protein EutN/carboxysome	eutN	-	-	ko:K04028	-	-	-	-	ko00000	-	-	-	EutN_CcmL
SX2_k127_1656753_4	1499967.BAYZ01000013_gene6423	3.843e-19	102.0	COG4576@1|root,COG4576@2|Bacteria,2NS06@2323|unclassified Bacteria	2|Bacteria	CQ	Ethanolamine utilisation protein EutN/carboxysome	eutN	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716	-	ko:K04028	-	-	-	-	ko00000	-	-	-	EutN_CcmL
SX2_k127_1656753_2	1499967.BAYZ01000013_gene6424	2.351e-56	209.0	COG0698@1|root,COG0698@2|Bacteria,2NPF4@2323|unclassified Bacteria	2|Bacteria	G	ribose 5-phosphate isomerase B	upp	-	2.4.2.9,5.3.1.6	ko:K00761,ko:K01808	ko00030,ko00051,ko00240,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00240,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R00966,R01056,R09030	RC00063,RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB,UPRTase
SX2_k127_1656753_1	1499967.BAYZ01000013_gene6425	7.991e-89	301.0	COG0274@1|root,COG0274@2|Bacteria,2NP8Z@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	2.7.1.15,4.1.2.4	ko:K00852,ko:K01619	ko00030,map00030	-	R01051,R01066,R02750	RC00002,RC00017,RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
SX2_k127_1658324_0	1254432.SCE1572_35190	6.188e-113	384.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,42NCX@68525|delta/epsilon subdivisions,2WJUZ@28221|Deltaproteobacteria,2YYCD@29|Myxococcales	28221|Deltaproteobacteria	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
SX2_k127_1658324_1	497964.CfE428DRAFT_4447	3.644e-64	243.0	COG1721@1|root,COG1721@2|Bacteria,46VTM@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
SX2_k127_1658324_2	525904.Tter_1736	6.507e-38	164.0	COG2304@1|root,COG2304@2|Bacteria,2NQHG@2323|unclassified Bacteria	2|Bacteria	S	Aerotolerance regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
SX2_k127_1658324_3	886293.Sinac_2617	2.247e-19	104.0	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,2IXKI@203682|Planctomycetes	203682|Planctomycetes	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	GATase1_like,VWA,VWA_3
SX2_k127_1664469_2	1304880.JAGB01000002_gene2266	2.628e-90	306.0	COG1277@1|root,COG1277@2|Bacteria,1UZXS@1239|Firmicutes,248ME@186801|Clostridia	186801|Clostridia	N	Psort location CytoplasmicMembrane, score	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_2,ABC2_membrane_3,ABC2_membrane_5
SX2_k127_1664469_1	1304880.JAGB01000002_gene2265	2.658e-107	364.0	COG3225@1|root,COG3225@2|Bacteria,1TT1J@1239|Firmicutes,24BC2@186801|Clostridia	186801|Clostridia	N	-transport system	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3,ABC_transp_aux
SX2_k127_1664469_0	1304880.JAGB01000002_gene2264	2.138e-121	406.0	2DBSS@1|root,2ZATI@2|Bacteria,1V13H@1239|Firmicutes,24D92@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
SX2_k127_1664469_3	1123274.KB899431_gene3279	1.419e-82	284.0	COG1774@1|root,COG1774@2|Bacteria,2J5RE@203691|Spirochaetes	203691|Spirochaetes	S	PFAM PSP1 C-terminal conserved region	-	-	-	-	-	-	-	-	-	-	-	-	PSP1
SX2_k127_1664469_5	1120985.AUMI01000005_gene2489	2.56e-13	76.0	COG1728@1|root,COG1728@2|Bacteria,1VF6M@1239|Firmicutes,4H500@909932|Negativicutes	909932|Negativicutes	S	Protein of unknown function (DUF327)	-	-	-	ko:K09770	-	-	-	-	ko00000	-	-	-	DUF327
SX2_k127_1664469_4	573413.Spirs_3189	2.582e-31	125.0	COG1664@1|root,COG1664@2|Bacteria,2J82J@203691|Spirochaetes	203691|Spirochaetes	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
SX2_k127_1692266_1	158189.SpiBuddy_2921	7.587e-53	190.0	COG1200@1|root,COG1200@2|Bacteria,2J5ET@203691|Spirochaetes	203691|Spirochaetes	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
SX2_k127_1692266_2	596324.TREVI0001_1169	3.057e-45	169.0	COG0742@1|root,COG0742@2|Bacteria,2J7B5@203691|Spirochaetes	203691|Spirochaetes	L	RNA methyltransferase, RsmD family	yhhF	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth95
SX2_k127_1692266_0	1307761.L21SP2_0552	5.369e-112	391.0	COG1501@1|root,COG1501@2|Bacteria,2J722@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.177	ko:K01811	-	-	-	-	ko00000,ko01000	-	GH31	-	Gal_mutarotas_2,Glyco_hydro_31
SX2_k127_1692266_4	386456.JQKN01000002_gene2431	7.073e-21	102.0	arCOG10857@1|root,arCOG10857@2157|Archaea,2Y4UI@28890|Euryarchaeota	28890|Euryarchaeota	S	Putative auto-transporter adhesin, head GIN domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2807
SX2_k127_1692266_5	243275.TDE_2428	8.409e-21	93.0	COG0267@1|root,COG0267@2|Bacteria,2J8UW@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
SX2_k127_1692266_6	889378.Spiaf_0542	4.717e-15	78.0	COG0690@1|root,COG0690@2|Bacteria,2J9CX@203691|Spirochaetes	203691|Spirochaetes	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
SX2_k127_1692266_3	1123274.KB899411_gene3124	5.921e-23	101.0	COG0250@1|root,COG0250@2|Bacteria,2J7FV@203691|Spirochaetes	203691|Spirochaetes	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
SX2_k127_1698606_0	861299.J421_2767	1.033e-228	720.0	COG0085@1|root,COG0085@2|Bacteria,1ZSQH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
SX2_k127_1698606_1	1379270.AUXF01000004_gene3046	3.395e-140	448.0	COG0086@1|root,COG0303@1|root,COG0086@2|Bacteria,COG0303@2|Bacteria,1ZSZQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
SX2_k127_1717226_2	886293.Sinac_6114	2.458e-37	156.0	COG0673@1|root,COG0673@2|Bacteria,2J27T@203682|Planctomycetes	203682|Planctomycetes	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX2_k127_1717226_0	1267535.KB906767_gene3349	1.087e-131	428.0	COG1063@1|root,COG1063@2|Bacteria,3Y6II@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
SX2_k127_1717226_1	1120973.AQXL01000125_gene3179	4.09e-87	297.0	COG3875@1|root,COG3875@2|Bacteria,1TQ1C@1239|Firmicutes,4HDCE@91061|Bacilli	91061|Bacilli	S	Domain of unknown function (DUF2088)	larA	-	5.1.2.1	ko:K22373	ko00620,map00620	-	R01450	RC00519	ko00000,ko00001,ko01000	-	-	-	DUF2088
SX2_k127_17273_1	104355.XP_007861418.1	4.303e-10	73.0	28IND@1|root,2QQZC@2759|Eukaryota,39VSX@33154|Opisthokonta,3NVZE@4751|Fungi,3V3SZ@5204|Basidiomycota,2252K@155619|Agaricomycetes,3H24U@355688|Agaricomycetes incertae sedis	4751|Fungi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,UvrD-helicase,UvrD_C
SX2_k127_17273_0	1304885.AUEY01000024_gene2722	5.674e-117	389.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,42N0C@68525|delta/epsilon subdivisions,2WJQQ@28221|Deltaproteobacteria,2MJ61@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.3,1.2.99.10	ko:K00128,ko:K22445	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
SX2_k127_1750239_4	335543.Sfum_0713	2.947e-41	173.0	COG1181@1|root,COG1181@2|Bacteria,1N4F5@1224|Proteobacteria,42NYM@68525|delta/epsilon subdivisions,2WKTX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlB1	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
SX2_k127_1750239_0	1121861.KB899916_gene1707	2.254e-185	589.0	COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,2TT31@28211|Alphaproteobacteria,2JPK9@204441|Rhodospirillales	204441|Rhodospirillales	E	lysine 2,3-aminomutase	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SX2_k127_1750239_3	1000569.HMPREF1040_0884	6.179e-63	238.0	COG2081@1|root,COG2081@2|Bacteria,1TQ6E@1239|Firmicutes,4H2G0@909932|Negativicutes	909932|Negativicutes	S	Flavoprotein family	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
SX2_k127_1750239_1	926550.CLDAP_19630	3.948e-119	400.0	COG2262@1|root,COG2262@2|Bacteria,2G634@200795|Chloroflexi	200795|Chloroflexi	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
SX2_k127_1750239_2	383372.Rcas_1628	5.129e-70	250.0	COG1691@1|root,COG1691@2|Bacteria,2G6SZ@200795|Chloroflexi	200795|Chloroflexi	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
SX2_k127_1750239_5	525898.Sdel_0655	5.019e-23	116.0	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,42USK@68525|delta/epsilon subdivisions,2YPZR@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
SX2_k127_1763354_3	665571.STHERM_c18330	6.015e-52	188.0	COG0101@1|root,COG0101@2|Bacteria,2J65Z@203691|Spirochaetes	203691|Spirochaetes	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
SX2_k127_1763354_0	665571.STHERM_c18340	4.179e-95	329.0	COG1655@1|root,COG1655@2|Bacteria,2J5GN@203691|Spirochaetes	203691|Spirochaetes	S	protein conserved in bacteria	-	-	-	ko:K09766	-	-	-	-	ko00000	-	-	-	DUF2225
SX2_k127_1763354_4	1123274.KB899413_gene769	7.997e-36	139.0	COG0736@1|root,COG0736@2|Bacteria,2J8AA@203691|Spirochaetes	203691|Spirochaetes	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
SX2_k127_1763354_2	1480694.DC28_05535	3.27e-57	212.0	COG4856@1|root,COG4856@2|Bacteria,2J5XW@203691|Spirochaetes	203691|Spirochaetes	S	YbbR-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
SX2_k127_1763354_1	573413.Spirs_1647	5.46e-79	278.0	COG1624@1|root,COG1624@2|Bacteria,2J5ZB@203691|Spirochaetes	203691|Spirochaetes	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
SX2_k127_1763354_5	404589.Anae109_2337	8.912e-27	113.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,42MMY@68525|delta/epsilon subdivisions,2WIXA@28221|Deltaproteobacteria,2YVIZ@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15,2.7.6.3	ko:K00796,ko:K13941	ko00790,ko01100,map00790,map01100	M00126,M00840,M00841	R03066,R03067,R03503	RC00002,RC00017,RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
SX2_k127_1772754_2	1499967.BAYZ01000159_gene503	0.000774	51.0	COG2407@1|root,COG2407@2|Bacteria	2|Bacteria	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1772754_0	926549.KI421517_gene3391	1.35e-173	551.0	COG0673@1|root,COG0673@2|Bacteria,4NG5E@976|Bacteroidetes,47NZU@768503|Cytophagia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX2_k127_1772754_1	1487921.DP68_16700	3.43e-78	267.0	COG1902@1|root,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,24C9J@186801|Clostridia,36F9D@31979|Clostridiaceae	186801|Clostridia	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
SX2_k127_1775110_0	665571.STHERM_c18260	2.293e-191	631.0	COG0215@1|root,COG0215@2|Bacteria,2J618@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
SX2_k127_1775110_3	1480694.DC28_14910	5.934e-41	173.0	COG1595@1|root,COG1595@2|Bacteria,2J64C@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SX2_k127_1775110_4	744872.Spica_0665	5.37e-19	98.0	2FF1T@1|root,34707@2|Bacteria,2J82I@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1775110_2	573413.Spirs_2150	3.162e-94	335.0	COG1305@1|root,COG1305@2|Bacteria,2J57S@203691|Spirochaetes	203691|Spirochaetes	E	IPT TIG domain	-	-	-	-	-	-	-	-	-	-	-	-	TIG,Transglut_core
SX2_k127_1775110_1	744872.Spica_0671	2.18e-122	398.0	COG0664@1|root,COG0664@2|Bacteria,2J5G6@203691|Spirochaetes	203691|Spirochaetes	T	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
SX2_k127_1793650_0	1499967.BAYZ01000159_gene503	2.965e-160	515.0	COG2407@1|root,COG2407@2|Bacteria	2|Bacteria	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1793650_1	1160707.AJIK01000036_gene2233	9.014e-135	446.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,4H9VK@91061|Bacilli	91061|Bacilli	G	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	rbsA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0006810,GO:0008144,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015146,GO:0015399,GO:0015405,GO:0015407,GO:0015591,GO:0015608,GO:0015611,GO:0015749,GO:0015750,GO:0015752,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034219,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043211,GO:0043492,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0097159,GO:0097367,GO:1901265,GO:1901363	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
SX2_k127_1793650_2	1487921.DP68_16685	3.002e-27	118.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,24AHZ@186801|Clostridia,36VRB@31979|Clostridiaceae	186801|Clostridia	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
SX2_k127_1805093_4	1410630.JNKP01000001_gene2045	2.37e-77	271.0	COG0535@1|root,COG0535@2|Bacteria,1TR52@1239|Firmicutes,247SB@186801|Clostridia,27KV4@186928|unclassified Lachnospiraceae	186801|Clostridia	C	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
SX2_k127_1805093_3	443144.GM21_1870	5.858e-102	363.0	COG2984@1|root,COG4191@1|root,COG2984@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WM1A@28221|Deltaproteobacteria,43TUP@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,PocR,Response_reg,SBP_bac_3,sCache_2
SX2_k127_1805093_0	290397.Adeh_1758	4.257e-156	507.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YUJU@29|Myxococcales	28221|Deltaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	FHA,HTH_8,Response_reg,Sigma54_activat
SX2_k127_1805093_2	247490.KSU1_A0008	5.065e-116	401.0	COG4447@1|root,COG5492@1|root,COG4447@2|Bacteria,COG5492@2|Bacteria,2J3BX@203682|Planctomycetes	203682|Planctomycetes	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1805093_1	1499967.BAYZ01000182_gene4442	1.023e-129	422.0	COG0673@1|root,COG0673@2|Bacteria,2NQJN@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	iolG	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX2_k127_1805093_5	1499967.BAYZ01000117_gene3303	2.026e-30	125.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SX2_k127_1806557_4	1321815.HMPREF9193_00254	7.142e-07	59.0	2AMY9@1|root,31CVB@2|Bacteria,2J8XJ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1806557_3	1321778.HMPREF1982_03405	4.912e-12	76.0	COG0775@1|root,COG0775@2|Bacteria	2|Bacteria	F	adenosylhomocysteine nucleosidase activity	pfs	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
SX2_k127_1806557_0	1123274.KB899413_gene886	8.832e-79	283.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIAA-like,Usp
SX2_k127_1806557_2	204669.Acid345_2473	3.505e-59	211.0	COG2518@1|root,COG2518@2|Bacteria	2|Bacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
SX2_k127_1806557_1	1123274.KB899413_gene884	5.099e-67	241.0	COG0399@1|root,COG0399@2|Bacteria,2J6I3@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
SX2_k127_1816438_0	555079.Toce_1607	4.086e-64	228.0	COG2358@1|root,COG2358@2|Bacteria,1TPXW@1239|Firmicutes,2489U@186801|Clostridia,42FRJ@68295|Thermoanaerobacterales	186801|Clostridia	S	NMT1-like family	bcsP	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
SX2_k127_1816438_2	1307761.L21SP2_3448	5.828e-31	133.0	COG0584@1|root,COG0584@2|Bacteria	2|Bacteria	C	glycerophosphodiester phosphodiesterase activity	ugpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
SX2_k127_1816438_1	768710.DesyoDRAFT_3295	7.328e-54	199.0	COG0778@1|root,COG0778@2|Bacteria,1V0NJ@1239|Firmicutes,24FM7@186801|Clostridia,261PI@186807|Peptococcaceae	186801|Clostridia	C	PFAM Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	TM1586_NiRdase
SX2_k127_1816438_3	616991.JPOO01000001_gene4601	5.816e-29	126.0	COG5580@1|root,COG5580@2|Bacteria,4PK53@976|Bacteroidetes,1I3SX@117743|Flavobacteriia	976|Bacteroidetes	O	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
SX2_k127_1849738_4	760011.Spico_1592	2.333e-85	293.0	COG0322@1|root,COG0322@2|Bacteria,2J69M@203691|Spirochaetes	203691|Spirochaetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
SX2_k127_1849738_5	266117.Rxyl_2580	2.435e-39	158.0	COG0204@1|root,COG0204@2|Bacteria	2|Bacteria	I	Acyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
SX2_k127_1849738_0	33035.JPJF01000057_gene3105	1.853e-177	565.0	COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia,3XYME@572511|Blautia	186801|Clostridia	C	Psort location Cytoplasmic, score 8.87	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
SX2_k127_1849738_2	521045.Kole_0486	3.105e-152	494.0	COG2055@1|root,COG2055@2|Bacteria,2GDVH@200918|Thermotogae	200918|Thermotogae	C	Belongs to the LDH2 MDH2 oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Ldh_2
SX2_k127_1849738_1	649638.Trad_1838	5.667e-168	549.0	COG0747@1|root,COG0747@2|Bacteria,1WMAS@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	ABC-type dipeptide transport system periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
SX2_k127_1849738_3	649638.Trad_1852	3.372e-97	329.0	COG0601@1|root,COG0601@2|Bacteria,1WJ61@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EP	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
SX2_k127_1850153_4	1123274.KB899415_gene2510	7.932e-26	111.0	COG0640@1|root,COG0640@2|Bacteria,2J8H9@203691|Spirochaetes	203691|Spirochaetes	K	arsR family	-	-	-	ko:K22298	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
SX2_k127_1850153_2	644966.Tmar_1229	3.979e-60	226.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,3WCZD@538999|Clostridiales incertae sedis	186801|Clostridia	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
SX2_k127_1850153_1	665571.STHERM_c15880	2.822e-111	376.0	COG0301@1|root,COG0301@2|Bacteria,2J64Z@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
SX2_k127_1850153_5	573413.Spirs_1898	4.04e-23	106.0	COG2331@1|root,COG2331@2|Bacteria,2J904@203691|Spirochaetes	203691|Spirochaetes	S	FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
SX2_k127_1850153_0	665571.STHERM_c15890	7.659e-115	386.0	COG0107@1|root,COG0107@2|Bacteria,2J6FB@203691|Spirochaetes	203691|Spirochaetes	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
SX2_k127_1850153_3	552811.Dehly_0991	2.305e-54	211.0	COG0118@1|root,COG0118@2|Bacteria,2G6FD@200795|Chloroflexi,34D8Q@301297|Dehalococcoidia	301297|Dehalococcoidia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
SX2_k127_1853177_2	573413.Spirs_1891	2.235e-12	74.0	COG1344@1|root,COG1344@2|Bacteria,2J5TJ@203691|Spirochaetes	203691|Spirochaetes	N	Component of the core of the flagella	-	-	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
SX2_k127_1853177_0	545694.TREPR_2686	5.739e-48	180.0	COG1564@1|root,COG1564@2|Bacteria,2J7RD@203691|Spirochaetes	203691|Spirochaetes	H	Thiamin pyrophosphokinase, catalytic domain	-	-	2.7.6.2	ko:K00949	ko00730,ko01100,map00730,map01100	-	R00619	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TPK_B1_binding,TPK_catalytic
SX2_k127_1860592_5	573413.Spirs_1737	1.023e-84	284.0	COG0664@1|root,COG0664@2|Bacteria,2J6ZR@203691|Spirochaetes	203691|Spirochaetes	K	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
SX2_k127_1860592_4	1121430.JMLG01000014_gene1929	4.419e-101	333.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia,260MZ@186807|Peptococcaceae	186801|Clostridia	E	PFAM ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
SX2_k127_1860592_3	926569.ANT_12870	4.324e-109	360.0	COG0411@1|root,COG0411@2|Bacteria,2G5W6@200795|Chloroflexi	200795|Chloroflexi	E	PFAM ABC transporter related	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
SX2_k127_1860592_2	926569.ANT_12880	1.937e-113	381.0	COG4177@1|root,COG4177@2|Bacteria,2G6D8@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
SX2_k127_1860592_1	926569.ANT_12890	9.647e-133	434.0	COG0559@1|root,COG0559@2|Bacteria,2G6FM@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
SX2_k127_1860592_0	926569.ANT_12900	7.902e-147	473.0	COG0683@1|root,COG0683@2|Bacteria,2G6Q1@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
SX2_k127_1862191_5	981369.JQMJ01000004_gene4023	1.276e-05	57.0	COG0584@1|root,COG0584@2|Bacteria,2GM3M@201174|Actinobacteria,2NI3X@228398|Streptacidiphilus	201174|Actinobacteria	C	Glycerophosphoryl diester phosphodiesterase family	-	-	3.1.22.1,3.1.4.46	ko:K01126,ko:K01158	ko00564,ko04142,map00564,map04142	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD,Inositol_P
SX2_k127_1862191_2	1121085.AUCI01000002_gene3874	2.562e-73	256.0	COG0717@1|root,COG0717@2|Bacteria,1V1BE@1239|Firmicutes,4HGR4@91061|Bacilli,1ZFUB@1386|Bacillus	91061|Bacilli	F	2'-deoxycytidine 5'-triphosphate deaminase (DCD)	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
SX2_k127_1862191_4	1536772.R70723_15160	3.242e-59	223.0	COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,4HBDB@91061|Bacilli,26RMX@186822|Paenibacillaceae	91061|Bacilli	G	Glycoside hydrolase family 3	nagZ	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4309,Glyco_hydro_3
SX2_k127_1862191_0	671143.DAMO_2519	1.693e-91	315.0	COG1373@1|root,COG1373@2|Bacteria,2NQZ6@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143,HTH_24,HTH_IclR
SX2_k127_1862191_1	247633.GP2143_14561	4.176e-83	298.0	COG2211@1|root,COG2211@2|Bacteria	2|Bacteria	G	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX2_k127_1862191_3	1382359.JIAL01000001_gene2001	2.576e-59	228.0	28JDZ@1|root,2Z988@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1875922_2	665571.STHERM_c09320	3.197e-31	123.0	COG0455@1|root,COG0455@2|Bacteria,2J5B7@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the ParA family	fleN	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	AAA_31,CbiA,ParA
SX2_k127_1875922_1	1480694.DC28_02445	6.364e-126	408.0	COG1191@1|root,COG1191@2|Bacteria,2J5RA@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the sigma-70 factor family	fliA	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
SX2_k127_1875922_0	665571.STHERM_c09350	7.157e-188	606.0	COG1315@1|root,COG1315@2|Bacteria,2J5S8@203691|Spirochaetes	203691|Spirochaetes	L	COGs COG1315 polymerase most protein contain PALM domain HD hydrolase domain and Zn-ribbon domain	-	-	-	ko:K09749	-	-	-	-	ko00000	-	-	-	FapA,Jag_N
SX2_k127_1875922_3	545694.TREPR_2843	8.257e-08	58.0	29A3I@1|root,31CTV@2|Bacteria,2J8T8@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1875922_4	545694.TREPR_2842	2.782e-05	56.0	28TF5@1|root,2ZFP6@2|Bacteria,2J8Y7@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1884620_0	935948.KE386494_gene995	1.038e-137	446.0	COG2152@1|root,COG2152@2|Bacteria,1TQE7@1239|Firmicutes,249D0@186801|Clostridia,42FH9@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Glycosidase	-	-	2.4.1.319,2.4.1.320	ko:K18785	-	-	R10811,R10829	RC00049	ko00000,ko01000	-	-	-	Glyco_hydro_130
SX2_k127_1884620_2	1094508.Tsac_0458	9.254e-33	136.0	COG0204@1|root,COG0204@2|Bacteria,1V5X9@1239|Firmicutes,24X01@186801|Clostridia	186801|Clostridia	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1884620_3	1120973.AQXL01000135_gene1492	4.371e-20	95.0	COG1695@1|root,COG1695@2|Bacteria,1VAKA@1239|Firmicutes,4HMW5@91061|Bacilli	91061|Bacilli	K	DNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	PadR
SX2_k127_1884620_4	221027.JO40_02695	4.603e-05	54.0	28X9U@1|root,2ZJ7V@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1884620_5	1123274.KB899411_gene3193	0.0004185	44.0	COG2236@1|root,COG2236@2|Bacteria,2JAE0@203691|Spirochaetes	203691|Spirochaetes	F	PFAM Phosphoribosyl transferase domain	-	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
SX2_k127_1890294_0	1185876.BN8_04974	9.256e-122	395.0	COG0673@1|root,COG0673@2|Bacteria,4NFY3@976|Bacteroidetes,47ME7@768503|Cytophagia	976|Bacteroidetes	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX2_k127_1890294_5	410358.Mlab_0708	7.101e-29	123.0	COG1751@1|root,arCOG04343@2157|Archaea,2XW2K@28890|Euryarchaeota,2N9M4@224756|Methanomicrobia	224756|Methanomicrobia	S	Pyruvate kinase, alpha/beta domain	-	-	-	ko:K09126	-	-	-	-	ko00000	-	-	-	PK_C
SX2_k127_1890294_1	243274.THEMA_07915	2.017e-102	358.0	COG4638@1|root,COG4638@2|Bacteria,2GCAJ@200918|Thermotogae	200918|Thermotogae	P	Rieske (2Fe-2S) domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
SX2_k127_1890294_2	530564.Psta_2824	7.223e-45	185.0	COG0524@1|root,COG0524@2|Bacteria,2J3WH@203682|Planctomycetes	203682|Planctomycetes	H	PFAM PfkB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
SX2_k127_1890294_4	42345.XP_008777423.1	6.333e-32	134.0	COG1535@1|root,2QQB1@2759|Eukaryota,37IJ0@33090|Viridiplantae,3GBAF@35493|Streptophyta,3KNR3@4447|Liliopsida	35493|Streptophyta	Q	Isochorismatase family	-	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008936,GO:0009117,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0019362,GO:0019637,GO:0019674,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901360,GO:1901564	-	-	-	-	-	-	-	-	-	-	Isochorismatase
SX2_k127_1890294_3	1480694.DC28_11295	1.817e-42	158.0	COG1816@1|root,COG1816@2|Bacteria	2|Bacteria	F	deaminase activity	add	-	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
SX2_k127_1909071_2	96561.Dole_1132	5.688e-59	212.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42Y9H@68525|delta/epsilon subdivisions,2WUPN@28221|Deltaproteobacteria,2MN1Q@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SX2_k127_1909071_0	204669.Acid345_3014	7.779e-133	445.0	COG0784@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,3Y64H@57723|Acidobacteria,2JM5F@204432|Acidobacteriia	204432|Acidobacteriia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
SX2_k127_1909071_3	1173027.Mic7113_1680	5.315e-52	194.0	COG0784@1|root,COG0784@2|Bacteria,1G6K4@1117|Cyanobacteria,1HBJX@1150|Oscillatoriales	1117|Cyanobacteria	T	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
SX2_k127_1909071_1	179408.Osc7112_4243	1.821e-101	351.0	COG2202@1|root,COG4251@1|root,COG5278@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,COG5278@2|Bacteria,1G35U@1117|Cyanobacteria,1H78M@1150|Oscillatoriales	1117|Cyanobacteria	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF,GAF_2,GAF_3,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
SX2_k127_1913673_7	926550.CLDAP_03280	4.718e-57	204.0	COG1957@1|root,COG1957@2|Bacteria,2G7IF@200795|Chloroflexi	200795|Chloroflexi	F	PFAM Inosine uridine-preferring nucleoside hydrolase	-	-	3.2.2.1	ko:K01239	ko00230,ko00760,ko01100,map00230,map00760,map01100	-	R01245,R01273,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	IU_nuc_hydro
SX2_k127_1913673_1	1304880.JAGB01000002_gene1624	8.978e-189	605.0	COG0407@1|root,COG0407@2|Bacteria,1UY51@1239|Firmicutes,24DZF@186801|Clostridia	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX2_k127_1913673_5	688269.Theth_1004	2.041e-114	380.0	COG1638@1|root,COG1638@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	-	-	-	-	-	-	-	-	-	DctP
SX2_k127_1913673_2	665571.STHERM_c06140	1.108e-153	493.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	-	ko:K18829	-	-	-	-	ko00000,ko02048	-	-	-	Creatinase_N,Peptidase_M24
SX2_k127_1913673_3	665571.STHERM_c06150	2.747e-149	480.0	COG3181@1|root,COG3181@2|Bacteria,2J7TJ@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
SX2_k127_1913673_0	665571.STHERM_c06170	3.084e-192	611.0	COG3333@1|root,COG3333@2|Bacteria,2J70X@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
SX2_k127_1913673_4	665571.STHERM_c06180	1.104e-126	424.0	COG0673@1|root,COG0673@2|Bacteria,2J71R@203691|Spirochaetes	203691|Spirochaetes	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX2_k127_1913673_6	665571.STHERM_c06190	2.521e-68	239.0	COG2186@1|root,COG2186@2|Bacteria,2J7RF@203691|Spirochaetes	203691|Spirochaetes	K	FCD	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
SX2_k127_1913673_8	1267535.KB906767_gene5491	1.043e-56	207.0	COG1335@1|root,COG1335@2|Bacteria,3Y67T@57723|Acidobacteria	57723|Acidobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
SX2_k127_1913673_11	189425.PGRAT_01405	2.672e-26	123.0	COG2169@1|root,COG2169@2|Bacteria,1V44Y@1239|Firmicutes,4HN01@91061|Bacilli,26TE2@186822|Paenibacillaceae	91061|Bacilli	F	AraC family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18,HTH_AraC
SX2_k127_1913673_9	1449063.JMLS01000002_gene1263	1.273e-45	169.0	COG4209@1|root,COG4209@2|Bacteria,1TP33@1239|Firmicutes,4I6N2@91061|Bacilli,26TUX@186822|Paenibacillaceae	91061|Bacilli	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
SX2_k127_1916943_4	889378.Spiaf_0097	1.526e-53	194.0	COG0841@1|root,COG0841@2|Bacteria,2J5HW@203691|Spirochaetes	203691|Spirochaetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
SX2_k127_1916943_3	1480694.DC28_09155	5.381e-62	235.0	COG0845@1|root,COG0845@2|Bacteria,2J88F@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
SX2_k127_1916943_6	1307761.L21SP2_0030	1.176e-25	114.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	yhgD	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141	-	ko:K03577,ko:K09017	-	M00647	-	-	ko00000,ko00002,ko03000	-	-	-	TetR_N
SX2_k127_1916943_0	1123274.KB899407_gene239	3.056e-196	629.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2J65C@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
SX2_k127_1916943_7	573413.Spirs_0264	6.221e-15	84.0	COG4221@1|root,COG4221@2|Bacteria,2J85X@203691|Spirochaetes	203691|Spirochaetes	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SX2_k127_1916943_2	1089553.Tph_c24780	4.419e-93	327.0	COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,42F3G@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
SX2_k127_1916943_1	158190.SpiGrapes_1081	4.202e-118	409.0	COG1033@1|root,COG1033@2|Bacteria,2J636@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG1033 exporter of the RND superfamily protein	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
SX2_k127_1916943_5	573413.Spirs_0552	2.828e-50	184.0	COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,2J8E5@203691|Spirochaetes	203691|Spirochaetes	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
SX2_k127_191856_0	158190.SpiGrapes_1193	7.452e-228	739.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2J5FM@203691|Spirochaetes	203691|Spirochaetes	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
SX2_k127_191856_5	1123274.KB899426_gene2791	3.786e-39	156.0	COG0237@1|root,COG0237@2|Bacteria,2J810@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
SX2_k127_191856_7	545695.TREAZ_2239	3.197e-18	93.0	COG3087@1|root,COG3087@2|Bacteria,2J8S5@203691|Spirochaetes	203691|Spirochaetes	D	PFAM Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
SX2_k127_191856_2	1307761.L21SP2_0293	3.989e-111	367.0	COG1045@1|root,COG1045@2|Bacteria,2J73S@203691|Spirochaetes	203691|Spirochaetes	E	Serine acetyltransferase	-	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
SX2_k127_191856_8	4530.OS08T0127500-01	1.917e-15	81.0	COG1963@1|root,2RZ3E@2759|Eukaryota,37TQD@33090|Viridiplantae,3GHZD@35493|Streptophyta,3KUFW@4447|Liliopsida,3I314@38820|Poales	35493|Streptophyta	S	Divergent PAP2 family	-	-	-	ko:K09775	-	-	-	-	ko00000	-	-	-	DUF212
SX2_k127_191856_4	665571.STHERM_c22100	1.023e-44	182.0	COG2843@1|root,COG2843@2|Bacteria,2J6GA@203691|Spirochaetes	203691|Spirochaetes	M	Bacterial capsule synthesis protein	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
SX2_k127_191856_3	889378.Spiaf_1719	3.445e-55	204.0	COG0457@1|root,COG0457@2|Bacteria,2JAI6@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_191856_1	573413.Spirs_2898	3.214e-121	428.0	COG0389@1|root,COG0389@2|Bacteria,2J5NZ@203691|Spirochaetes	203691|Spirochaetes	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
SX2_k127_191856_6	1123274.KB899412_gene1488	2.413e-38	165.0	2DGWT@1|root,2ZXJS@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_192809_0	1379698.RBG1_1C00001G1489	4.697e-210	664.0	COG0443@1|root,COG0443@2|Bacteria,2NNU1@2323|unclassified Bacteria	2|Bacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
SX2_k127_192809_2	889378.Spiaf_1961	3.023e-45	172.0	COG0576@1|root,COG0576@2|Bacteria,2J7UP@203691|Spirochaetes	203691|Spirochaetes	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
SX2_k127_192809_1	1125863.JAFN01000001_gene389	7.459e-117	394.0	COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,42MNB@68525|delta/epsilon subdivisions,2WIXQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Belongs to the GPI family	pgi	-	2.2.1.2,5.3.1.9	ko:K01810,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
SX2_k127_192809_3	903814.ELI_3312	1.854e-44	168.0	COG1146@1|root,COG2006@1|root,COG1146@2|Bacteria,COG2006@2|Bacteria,1TRX2@1239|Firmicutes,249GX@186801|Clostridia,25VVJ@186806|Eubacteriaceae	186801|Clostridia	C	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Fer4_10,Fer4_7
SX2_k127_1928338_5	158189.SpiBuddy_1013	3.225e-11	67.0	COG1653@1|root,COG1653@2|Bacteria,2J728@203691|Spirochaetes	203691|Spirochaetes	G	bacterial extracellular solute-binding protein	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_8
SX2_k127_1928338_6	1121875.KB907550_gene641	4.579e-10	68.0	COG2114@1|root,COG2204@1|root,COG2114@2|Bacteria,COG2204@2|Bacteria,4NF1F@976|Bacteroidetes,1HZ1W@117743|Flavobacteriia	976|Bacteroidetes	T	Guanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Response_reg
SX2_k127_1928338_2	290397.Adeh_3195	1.31e-64	225.0	COG5649@1|root,COG5649@2|Bacteria,1RDDG@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
SX2_k127_1928338_3	1535287.JP74_08425	6.353e-50	188.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_6,Hydrolase_4
SX2_k127_1928338_7	929562.Emtol_1087	5.753e-06	59.0	COG3292@1|root,COG3292@2|Bacteria,4NI2T@976|Bacteroidetes,47KG1@768503|Cytophagia	976|Bacteroidetes	T	PFAM Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	Reg_prop,YceI
SX2_k127_1928338_0	330214.NIDE0577	3.005e-288	908.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF853,DUF87
SX2_k127_1928338_1	1128421.JAGA01000003_gene2944	2.784e-169	546.0	COG1640@1|root,COG1640@2|Bacteria,2NP2W@2323|unclassified Bacteria	2|Bacteria	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	iJN678.malQ	Glyco_hydro_77
SX2_k127_1928338_4	665571.STHERM_c10160	3.215e-45	173.0	COG2182@1|root,COG2182@2|Bacteria,2J5S3@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Bacterial extracellular solute-binding protein	-	-	-	ko:K15770	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	SBP_bac_8
SX2_k127_1937447_0	234267.Acid_0885	2.936e-234	733.0	COG3459@1|root,COG3459@2|Bacteria,3Y3E9@57723|Acidobacteria	57723|Acidobacteria	G	Putative glucoamylase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
SX2_k127_1937447_1	158189.SpiBuddy_0057	1.793e-11	67.0	COG0176@1|root,COG0176@2|Bacteria	2|Bacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
SX2_k127_1956693_0	573413.Spirs_2612	8.83e-116	386.0	COG0492@1|root,COG0492@2|Bacteria,2J7WA@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
SX2_k127_1956693_1	1122919.KB905582_gene3748	1.005e-31	141.0	COG0095@1|root,COG0095@2|Bacteria,1TQ5U@1239|Firmicutes,4HABG@91061|Bacilli,26S5X@186822|Paenibacillaceae	91061|Bacilli	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation	lipM	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
SX2_k127_1956693_2	573413.Spirs_2613	3.031e-28	122.0	COG1472@1|root,COG1472@2|Bacteria,2J5CS@203691|Spirochaetes	203691|Spirochaetes	G	Glycosyl hydrolase family 3	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
SX2_k127_197125_7	1307761.L21SP2_2222	2.609e-47	184.0	2EG9W@1|root,33A1P@2|Bacteria,2J9F9@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_197125_5	665571.STHERM_c02060	1.598e-70	248.0	COG2834@1|root,COG2834@2|Bacteria,2J7Z0@203691|Spirochaetes	203691|Spirochaetes	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
SX2_k127_197125_4	1480694.DC28_12410	2.602e-87	318.0	COG4591@1|root,COG4591@2|Bacteria,2JA02@203691|Spirochaetes	203691|Spirochaetes	M	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX2_k127_197125_1	1480694.DC28_12405	1.987e-115	384.0	COG4591@1|root,COG4591@2|Bacteria,2J7QZ@203691|Spirochaetes	203691|Spirochaetes	M	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX2_k127_197125_3	1480694.DC28_12400	3.592e-95	321.0	COG1136@1|root,COG1136@2|Bacteria,2J7FN@203691|Spirochaetes	203691|Spirochaetes	V	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003,ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX2_k127_197125_2	158189.SpiBuddy_2773	2.704e-106	359.0	COG0330@1|root,COG0330@2|Bacteria,2J73X@203691|Spirochaetes	203691|Spirochaetes	O	PFAM SPFH domain Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
SX2_k127_197125_6	1480694.DC28_12390	8.165e-49	177.0	COG1725@1|root,COG1725@2|Bacteria,2J9B8@203691|Spirochaetes	203691|Spirochaetes	K	transcriptional regulator	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
SX2_k127_197125_0	401526.TcarDRAFT_0292	1.85e-126	414.0	COG0174@1|root,COG0174@2|Bacteria,1TNZA@1239|Firmicutes,4H1WQ@909932|Negativicutes	909932|Negativicutes	E	Glutamate--ammonia ligase, catalytic domain protein	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
SX2_k127_1972005_1	521098.Aaci_1061	7.764e-124	403.0	COG0362@1|root,COG0362@2|Bacteria,1TP4I@1239|Firmicutes,4H9NC@91061|Bacilli	91061|Bacilli	G	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
SX2_k127_1972005_2	1242864.D187_008136	3.928e-118	409.0	COG0371@1|root,COG0371@2|Bacteria,1NAAM@1224|Proteobacteria	1224|Proteobacteria	C	Glycerol dehydrogenase and related enzymes	egsA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
SX2_k127_1972005_3	665571.STHERM_c12710	2.259e-41	160.0	COG1959@1|root,COG1959@2|Bacteria,2J8PQ@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator	-	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
SX2_k127_1972005_0	665571.STHERM_c14390	1.933e-170	548.0	COG0008@1|root,COG0008@2|Bacteria,2J5M7@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
SX2_k127_1972005_4	665571.STHERM_c14380	5.959e-19	87.0	COG0423@1|root,COG0423@2|Bacteria,2J57N@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
SX2_k127_2001920_1	351607.Acel_1323	9.579e-58	205.0	COG2229@1|root,COG2229@2|Bacteria,2HI46@201174|Actinobacteria,4EVUB@85013|Frankiales	201174|Actinobacteria	S	Conserved hypothetical ATP binding protein	cvnD10	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	ATP_bind_1
SX2_k127_2001920_2	316274.Haur_0845	3.946e-40	170.0	COG0457@1|root,COG0457@2|Bacteria,2G770@200795|Chloroflexi,374ST@32061|Chloroflexia	32061|Chloroflexia	S	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388
SX2_k127_2001920_3	1521187.JPIM01000002_gene3124	2.069e-30	128.0	COG2018@1|root,COG2018@2|Bacteria,2G8WW@200795|Chloroflexi,375M5@32061|Chloroflexia	32061|Chloroflexia	S	PFAM Roadblock LC7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
SX2_k127_2001920_0	590998.Celf_2007	4.701e-111	364.0	COG2804@1|root,COG2804@2|Bacteria,2I8C2@201174|Actinobacteria	201174|Actinobacteria	NU	type II secretion system protein E	pilB	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
SX2_k127_2006736_1	633148.Tagg_0083	0.0001032	45.0	COG0636@1|root,arCOG02455@2157|Archaea,2XQQG@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM H transporting two-sector ATPase C subunit	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
SX2_k127_2006736_2	694440.JOMF01000004_gene1360	0.0002789	50.0	COG1390@1|root,arCOG00869@2157|Archaea,2XWGX@28890|Euryarchaeota,2N9TB@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
SX2_k127_2006736_0	765177.Desmu_0081	1.71e-96	326.0	COG1155@1|root,arCOG00868@2157|Archaea,2XPZE@28889|Crenarchaeota	28889|Crenarchaeota	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044464,GO:0044769,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132,GO:1902600	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
SX2_k127_2008394_1	1267535.KB906767_gene4238	3.627e-114	376.0	COG0329@1|root,COG0329@2|Bacteria,3Y6I2@57723|Acidobacteria,2JMAW@204432|Acidobacteriia	204432|Acidobacteriia	EM	Dihydrodipicolinate synthetase family	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2008394_0	247490.KSU1_C1370	8.911e-241	777.0	COG0443@1|root,COG0443@2|Bacteria,2IWWS@203682|Planctomycetes	203682|Planctomycetes	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
SX2_k127_2008394_2	745014.OMB55_00003160	9.464e-77	267.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria,1J4DE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0006457,GO:0008150,GO:0009987	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
SX2_k127_2014898_0	1121405.dsmv_2518	1.73e-93	318.0	COG0167@1|root,COG0167@2|Bacteria,1MXER@1224|Proteobacteria,42QNP@68525|delta/epsilon subdivisions,2WMX5@28221|Deltaproteobacteria,2MMTR@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
SX2_k127_2014898_2	1291050.JAGE01000002_gene3639	4.817e-37	145.0	COG1433@1|root,COG1433@2|Bacteria,1V7KS@1239|Firmicutes,24MUB@186801|Clostridia,3WK48@541000|Ruminococcaceae	186801|Clostridia	S	Putative redox-active protein (C_GCAxxG_C_C)	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
SX2_k127_2014898_1	744872.Spica_0953	5.613e-57	201.0	COG0252@1|root,COG0252@2|Bacteria,2J7ZE@203691|Spirochaetes	203691|Spirochaetes	EJ	PFAM Asparaginase	-	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
SX2_k127_2021480_1	1268072.PSAB_02965	2.095e-33	136.0	COG4346@1|root,COG5650@1|root,COG4346@2|Bacteria,COG5650@2|Bacteria,1TSHX@1239|Firmicutes,4ISHD@91061|Bacilli,26SCF@186822|Paenibacillaceae	91061|Bacilli	O	Glycosyl transferase	-	-	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	F5_F8_type_C,GT87,PMT,PMT_2,PMT_4TMC
SX2_k127_2021480_0	1499967.BAYZ01000097_gene4328	1.718e-93	315.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	ydeD	-	-	-	-	-	-	-	-	-	-	-	EamA
SX2_k127_2045846_3	573413.Spirs_3823	1.972e-66	243.0	COG1674@1|root,COG1674@2|Bacteria,2J63D@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the FtsK SpoIIIE SftA family	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
SX2_k127_2045846_6	906968.Trebr_2382	4.532e-45	186.0	COG0741@1|root,COG0741@2|Bacteria,2J7A5@203691|Spirochaetes	203691|Spirochaetes	M	transglycosylase	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,TPR_6
SX2_k127_2045846_5	1123274.KB899410_gene3463	8.322e-46	179.0	COG1652@1|root,COG1652@2|Bacteria,2J6RK@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HSP70,LysM
SX2_k127_2045846_7	545695.TREAZ_2579	8.257e-24	117.0	COG0357@1|root,COG0357@2|Bacteria,2J72Y@203691|Spirochaetes	203691|Spirochaetes	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
SX2_k127_2045846_0	665571.STHERM_c02920	3.89e-248	781.0	COG0445@1|root,COG0445@2|Bacteria,2J5A1@203691|Spirochaetes	203691|Spirochaetes	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
SX2_k127_2045846_1	665571.STHERM_c02910	1.467e-116	404.0	COG0486@1|root,COG0486@2|Bacteria,2J5GU@203691|Spirochaetes	203691|Spirochaetes	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
SX2_k127_2045846_4	1195236.CTER_2292	1.815e-64	249.0	COG0730@1|root,COG0730@2|Bacteria,1TPMA@1239|Firmicutes,25CI8@186801|Clostridia,3WJ6E@541000|Ruminococcaceae	186801|Clostridia	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
SX2_k127_2045846_2	665571.STHERM_c19210	2.803e-85	308.0	COG4412@1|root,COG4412@2|Bacteria,2JAS0@203691|Spirochaetes	203691|Spirochaetes	S	Peptidase M30	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M30
SX2_k127_2047755_1	640511.BC1002_6699	3.414e-112	376.0	COG1032@1|root,COG1032@2|Bacteria,1R92G@1224|Proteobacteria,2WB71@28216|Betaproteobacteria,1K09Q@119060|Burkholderiaceae	28216|Betaproteobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
SX2_k127_2047755_2	365046.Rta_25120	7.472e-101	344.0	COG2114@1|root,COG3437@1|root,COG2114@2|Bacteria,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria,4AEKM@80864|Comamonadaceae	28216|Betaproteobacteria	T	cheY-homologous receiver domain	-	-	4.6.1.1	ko:K01768,ko:K07814,ko:K20977	ko00230,ko02020,ko02025,ko04113,ko04213,map00230,map02020,map02025,map04113,map04213	M00695,M00820	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	Guanylate_cyc,HD,Response_reg
SX2_k127_2047755_0	1121447.JONL01000001_gene465	1.116e-166	559.0	COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2X7E0@28221|Deltaproteobacteria,2MHE4@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_9,Response_reg,SBP_bac_3
SX2_k127_2047755_3	1226994.AMZB01000104_gene1407	4.141e-36	143.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,1RPH3@1236|Gammaproteobacteria,1YKNM@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
SX2_k127_206793_0	573413.Spirs_0929	0.0	1136.0	COG0542@1|root,COG0542@2|Bacteria,2J57C@203691|Spirochaetes	203691|Spirochaetes	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
SX2_k127_2072105_1	1031288.AXAA01000010_gene469	1.494e-27	132.0	COG0419@1|root,COG1196@1|root,COG0419@2|Bacteria,COG1196@2|Bacteria,1UQNY@1239|Firmicutes,24UHC@186801|Clostridia	186801|Clostridia	L	AAA domain	-	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_27
SX2_k127_2072105_0	1304284.L21TH_2026	1.358e-69	259.0	COG0420@1|root,COG0420@2|Bacteria,1V3MP@1239|Firmicutes,24J4M@186801|Clostridia	186801|Clostridia	L	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
SX2_k127_2072105_2	292564.Cyagr_2420	0.0007624	50.0	COG1032@1|root,COG1032@2|Bacteria,1G187@1117|Cyanobacteria,22RVA@167375|Cyanobium	1117|Cyanobacteria	C	Fe-S oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SX2_k127_211522_0	744872.Spica_1091	6.966e-64	238.0	2F58Y@1|root,33XV6@2|Bacteria,2J6V5@203691|Spirochaetes	203691|Spirochaetes	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
SX2_k127_2121744_1	1395587.P364_0122565	4.136e-05	57.0	COG5297@1|root,COG5297@2|Bacteria,1V1T2@1239|Firmicutes,4HUDU@91061|Bacilli,26S1Z@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the glycosyl hydrolase family 6	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM_3,Glyco_hydro_9
SX2_k127_2121744_0	1232410.KI421412_gene388	3.266e-19	103.0	COG5276@1|root,COG5276@2|Bacteria,1RBM1@1224|Proteobacteria,42TF9@68525|delta/epsilon subdivisions,2WPX5@28221|Deltaproteobacteria,43SNG@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
SX2_k127_2133159_0	1307761.L21SP2_3507	4.408e-240	751.0	COG0187@1|root,COG0187@2|Bacteria,2J67M@203691|Spirochaetes	203691|Spirochaetes	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
SX2_k127_2133159_1	1307761.L21SP2_0001	1.028e-167	538.0	COG0593@1|root,COG0593@2|Bacteria,2J5F6@203691|Spirochaetes	203691|Spirochaetes	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
SX2_k127_2133159_2	573413.Spirs_0003	4.575e-135	439.0	COG0592@1|root,COG0592@2|Bacteria,2J629@203691|Spirochaetes	203691|Spirochaetes	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
SX2_k127_2133159_3	573413.Spirs_0004	4.15e-78	288.0	COG1195@1|root,COG1195@2|Bacteria,2J5MP@203691|Spirochaetes	203691|Spirochaetes	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
SX2_k127_2133159_4	744872.Spica_0004	2.915e-16	87.0	COG5512@1|root,COG5512@2|Bacteria,2J8RK@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
SX2_k127_2162644_3	384616.Pisl_0775	3.771e-05	48.0	COG4231@1|root,arCOG01609@2157|Archaea,2XPN3@28889|Crenarchaeota	28889|Crenarchaeota	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
SX2_k127_2162644_0	906968.Trebr_0890	1.016e-172	552.0	COG0541@1|root,COG0541@2|Bacteria,2J5MF@203691|Spirochaetes	203691|Spirochaetes	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
SX2_k127_2162644_2	1123274.KB899415_gene2481	2.074e-23	103.0	COG0228@1|root,COG0228@2|Bacteria,2J8AD@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
SX2_k127_2162644_1	1123274.KB899415_gene2482	3.566e-28	119.0	COG1837@1|root,COG1837@2|Bacteria,2J92T@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the UPF0109 family	yhbY	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
SX2_k127_2178884_0	1380391.JIAS01000001_gene2660	6.615e-102	351.0	COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,2U4F6@28211|Alphaproteobacteria,2JTMT@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2178884_1	1307759.JOMJ01000003_gene1170	3.655e-37	146.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2M7UM@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
SX2_k127_2186952_1	1121403.AUCV01000013_gene3925	1.769e-48	181.0	COG2122@1|root,COG2122@2|Bacteria,1MV9Z@1224|Proteobacteria,42PMZ@68525|delta/epsilon subdivisions,2WMF7@28221|Deltaproteobacteria,2MJ13@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM ApbE family	-	-	-	ko:K09740	-	-	-	-	ko00000	-	-	-	-
SX2_k127_2186952_0	591019.Shell_1295	5.596e-79	290.0	COG1269@1|root,arCOG04138@2157|Archaea,2XQ7V@28889|Crenarchaeota	28889|Crenarchaeota	C	Belongs to the V-ATPase 116 kDa subunit family	atpI	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006873,GO:0006885,GO:0007035,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019725,GO:0019829,GO:0019899,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042592,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044769,GO:0045851,GO:0046034,GO:0046390,GO:0046483,GO:0046961,GO:0048878,GO:0050801,GO:0051117,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0055086,GO:0065007,GO:0065008,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
SX2_k127_2189338_0	909663.KI867150_gene1265	5.323e-218	693.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJZ3@28221|Deltaproteobacteria,2MQ7P@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
SX2_k127_2189338_1	909663.KI867150_gene894	2.657e-109	367.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,42MCV@68525|delta/epsilon subdivisions,2WJI2@28221|Deltaproteobacteria,2MQAR@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	TIGRFAM Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
SX2_k127_2189338_2	1121904.ARBP01000012_gene1387	3.368e-109	372.0	COG0205@1|root,COG0205@2|Bacteria,4NF8F@976|Bacteroidetes,47JHZ@768503|Cytophagia	976|Bacteroidetes	G	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	-	-	-	-	-	-	-	-	-	-	-	-	PFK
SX2_k127_220193_0	1123274.KB899407_gene180	2.829e-158	511.0	COG0664@1|root,COG0664@2|Bacteria,2J6CX@203691|Spirochaetes	203691|Spirochaetes	T	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_220193_1	517417.Cpar_0066	6.269e-58	207.0	COG0778@1|root,COG0778@2|Bacteria,1FEBI@1090|Chlorobi	1090|Chlorobi	C	PFAM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SX2_k127_2205967_2	572479.Hprae_0502	2.284e-20	102.0	COG0715@1|root,COG0715@2|Bacteria,1TT2F@1239|Firmicutes,249M2@186801|Clostridia	186801|Clostridia	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
SX2_k127_2205967_0	1304880.JAGB01000002_gene1777	2.188e-73	258.0	COG0673@1|root,COG0673@2|Bacteria,1TT9N@1239|Firmicutes,24EGX@186801|Clostridia	186801|Clostridia	S	Oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX2_k127_2205967_1	1041147.AUFB01000024_gene5164	9.908e-34	141.0	COG4300@1|root,COG4300@2|Bacteria,1N2FB@1224|Proteobacteria,2VEDF@28211|Alphaproteobacteria,4BEBV@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Cadmium resistance transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cad
SX2_k127_2205967_3	1480694.DC28_14875	3.129e-20	92.0	COG0454@1|root,COG0456@2|Bacteria,2J7A2@203691|Spirochaetes	203691|Spirochaetes	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SX2_k127_2206063_1	264732.Moth_0976	6.881e-12	74.0	COG0164@1|root,COG0164@2|Bacteria,1V1D6@1239|Firmicutes,248IT@186801|Clostridia,42FWD@68295|Thermoanaerobacterales	186801|Clostridia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
SX2_k127_2206063_0	1123274.KB899415_gene2477	4.404e-281	890.0	COG1196@1|root,COG1196@2|Bacteria,2J57J@203691|Spirochaetes	203691|Spirochaetes	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N
SX2_k127_2213794_2	644966.Tmar_1531	1.093e-45	183.0	COG1175@1|root,COG1175@2|Bacteria,1TPTZ@1239|Firmicutes,248DR@186801|Clostridia,3WCMG@538999|Clostridiales incertae sedis	186801|Clostridia	P	Carbohydrate ABC transporter membrane protein 1, CUT1 family	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX2_k127_2213794_4	565655.ECBG_00379	1.785e-19	100.0	COG1609@1|root,COG1609@2|Bacteria,1TP9Q@1239|Firmicutes,4HG13@91061|Bacilli,4AZ8G@81852|Enterococcaceae	91061|Bacilli	K	helix_turn_helix gluconate operon transcriptional repressor	rliB	-	-	-	-	-	-	-	-	-	-	-	GntR,Peripla_BP_3
SX2_k127_2213794_6	1121024.AUCD01000014_gene1849	7.585e-10	70.0	COG2188@1|root,COG2188@2|Bacteria,1V0UW@1239|Firmicutes,4HD10@91061|Bacilli,27FQ4@186828|Carnobacteriaceae	91061|Bacilli	K	UTRA	-	-	-	ko:K03492	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
SX2_k127_2213794_5	240015.ACP_2794	3.135e-16	91.0	COG1609@1|root,COG1609@2|Bacteria,3Y423@57723|Acidobacteria,2JHRM@204432|Acidobacteriia	204432|Acidobacteriia	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
SX2_k127_2213794_1	1122915.AUGY01000036_gene1591	3.865e-66	239.0	COG0111@1|root,COG0111@2|Bacteria,1U2XG@1239|Firmicutes,4HF1I@91061|Bacilli,26VA2@186822|Paenibacillaceae	91061|Bacilli	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
SX2_k127_2213794_0	589873.EP13_15655	1.15e-76	272.0	COG1028@1|root,COG1028@2|Bacteria,1MW9A@1224|Proteobacteria,1RPJZ@1236|Gammaproteobacteria,465IP@72275|Alteromonadaceae	1236|Gammaproteobacteria	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SX2_k127_2213794_3	1038860.AXAP01000063_gene2448	3.78e-20	94.0	COG0154@1|root,COG0154@2|Bacteria,1MWRI@1224|Proteobacteria,2TTJU@28211|Alphaproteobacteria,3JVBW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Amidase	-	-	3.5.1.4,6.3.5.6,6.3.5.7	ko:K01426,ko:K02433	ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120	-	R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
SX2_k127_2231351_10	1123274.KB899412_gene1510	1.087e-10	73.0	2DZ40@1|root,34CCA@2|Bacteria,2J8AY@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2232
SX2_k127_2231351_5	744872.Spica_1425	1.397e-39	160.0	COG0359@1|root,COG0359@2|Bacteria,2J6J9@203691|Spirochaetes	203691|Spirochaetes	J	Binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
SX2_k127_2231351_0	1123274.KB899412_gene1512	5.085e-168	542.0	COG0305@1|root,COG0305@2|Bacteria,2J590@203691|Spirochaetes	203691|Spirochaetes	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
SX2_k127_2231351_9	744872.Spica_1423	1.79e-11	68.0	2AMU2@1|root,31CQK@2|Bacteria,2J8GC@203691|Spirochaetes	203691|Spirochaetes	S	Late competence development protein ComFB	-	-	-	ko:K02241	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	ComFB
SX2_k127_2231351_8	545694.TREPR_2679	2.153e-29	137.0	2FE8F@1|root,34689@2|Bacteria,2J592@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2231351_6	573413.Spirs_2871	1.778e-39	169.0	2AMCR@1|root,31C85@2|Bacteria,2J6BE@203691|Spirochaetes	203691|Spirochaetes	S	CpXC protein	-	-	-	-	-	-	-	-	-	-	-	-	CpXC
SX2_k127_2231351_1	1123274.KB899412_gene1516	2.005e-104	358.0	COG0750@1|root,COG0750@2|Bacteria,2J616@203691|Spirochaetes	203691|Spirochaetes	M	zinc metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
SX2_k127_2231351_2	665571.STHERM_c13110	5.348e-95	339.0	COG0743@1|root,COG0743@2|Bacteria,2J5M4@203691|Spirochaetes	203691|Spirochaetes	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
SX2_k127_2231351_7	744872.Spica_1419	1.743e-33	145.0	COG4589@1|root,COG4589@2|Bacteria,2J7JM@203691|Spirochaetes	203691|Spirochaetes	S	Phosphatidate cytidylyltransferase	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
SX2_k127_2231351_3	545695.TREAZ_0620	9.734e-86	299.0	COG0020@1|root,COG0020@2|Bacteria,2J5Y6@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
SX2_k127_2231351_4	573413.Spirs_2866	1.979e-71	248.0	COG0233@1|root,COG0233@2|Bacteria,2J6PZ@203691|Spirochaetes	203691|Spirochaetes	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
SX2_k127_2231351_11	744872.Spica_1416	6.356e-09	57.0	COG0264@1|root,COG0264@2|Bacteria,2J58B@203691|Spirochaetes	203691|Spirochaetes	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
SX2_k127_2237623_0	266117.Rxyl_3061	3.765e-78	275.0	2CBE1@1|root,32RT5@2|Bacteria,2IQDS@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2237623_1	313606.M23134_04012	1.016e-10	66.0	COG0729@1|root,COG0729@2|Bacteria,4NMUN@976|Bacteroidetes,47Y2C@768503|Cytophagia	976|Bacteroidetes	M	Surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag
SX2_k127_224604_11	742738.HMPREF9460_00540	3.621e-41	156.0	28NVW@1|root,2ZBTV@2|Bacteria,1VR7H@1239|Firmicutes,24MK4@186801|Clostridia,26A2Y@186813|unclassified Clostridiales	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_224604_4	309799.DICTH_0392	5.792e-121	409.0	COG4134@1|root,COG4134@2|Bacteria	2|Bacteria	S	Bacterial extracellular solute-binding protein	-	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_8
SX2_k127_224604_5	309799.DICTH_0393	4.278e-116	386.0	COG3842@1|root,COG3842@2|Bacteria	2|Bacteria	P	ATPase activity	-	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
SX2_k127_224604_7	309799.DICTH_0394	6.888e-99	337.0	COG1176@1|root,COG1176@2|Bacteria	2|Bacteria	P	putrescine transport	-	-	-	ko:K02054	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
SX2_k127_224604_8	309799.DICTH_0395	3.744e-74	271.0	COG1177@1|root,COG1177@2|Bacteria	2|Bacteria	P	DNA import into cell involved in transformation	-	-	-	ko:K02053	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
SX2_k127_224604_3	1089547.KB913013_gene3663	4.637e-160	518.0	COG3525@1|root,COG3525@2|Bacteria,4NE08@976|Bacteroidetes,47K79@768503|Cytophagia	976|Bacteroidetes	G	PFAM Glycoside hydrolase, family 20, catalytic core	-	-	3.2.1.52	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	M00079	R00022,R06004,R11316	RC00049	ko00000,ko00001,ko00002,ko01000,ko03110	-	GH20	-	CHB_HEX_C_1,F5_F8_type_C,Fn3_assoc,Glyco_hydro_20,Glyco_hydro_20b
SX2_k127_224604_1	1094980.Mpsy_0076	4.549e-201	635.0	COG0019@1|root,arCOG02268@2157|Archaea,2XSY8@28890|Euryarchaeota,2N93Z@224756|Methanomicrobia	224756|Methanomicrobia	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
SX2_k127_224604_9	868131.MSWAN_1874	8.415e-69	241.0	COG2041@1|root,arCOG00266@2157|Archaea	2157|Archaea	P	COG2041 Sulfite oxidase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB,Oxidored_molyb
SX2_k127_224604_2	289376.THEYE_A0114	3.608e-172	552.0	COG0473@1|root,COG0473@2|Bacteria,3J0JQ@40117|Nitrospirae	40117|Nitrospirae	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
SX2_k127_224604_10	443254.Marpi_1805	6.176e-49	185.0	COG1647@1|root,COG1647@2|Bacteria,2GCT5@200918|Thermotogae	200918|Thermotogae	S	Alpha/beta hydrolase family	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
SX2_k127_224604_0	335543.Sfum_2376	7.206e-281	875.0	COG2987@1|root,COG2987@2|Bacteria,1MU4W@1224|Proteobacteria,42PUK@68525|delta/epsilon subdivisions,2WIN4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
SX2_k127_224604_6	1304874.JAFY01000007_gene2347	9.097e-110	364.0	COG3643@1|root,COG3643@2|Bacteria,3T9TJ@508458|Synergistetes	508458|Synergistetes	E	TIGRFAM glutamate formiminotransferase	ftcD	-	2.1.2.5	ko:K00603	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R03189	RC00165,RC00221,RC00223,RC00870	ko00000,ko00001,ko01000	-	-	-	FTCD,FTCD_N
SX2_k127_226039_2	665571.STHERM_c07970	7.19e-24	109.0	COG0517@1|root,COG1762@1|root,COG0517@2|Bacteria,COG1762@2|Bacteria	2|Bacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system	ptsN_1	-	2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	CBS,HTH_17,PTS_EIIA_2
SX2_k127_226039_0	234267.Acid_7084	2.846e-187	593.0	COG0524@1|root,COG0524@2|Bacteria,3Y3DE@57723|Acidobacteria	57723|Acidobacteria	G	PfkB domain protein	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
SX2_k127_226039_1	665571.STHERM_c19870	8.405e-160	524.0	COG2730@1|root,COG2730@2|Bacteria,2J6EW@203691|Spirochaetes	203691|Spirochaetes	G	Cellulase (glycosyl hydrolase family 5)	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase
SX2_k127_226092_4	744872.Spica_1887	6.147e-60	218.0	COG0477@1|root,COG2814@2|Bacteria,2JAJU@203691|Spirochaetes	203691|Spirochaetes	EGP	Major Facilitator Superfamily	-	-	-	ko:K08161	-	-	-	-	ko00000,ko02000	2.A.1.2.20	-	-	MFS_1
SX2_k127_226092_5	33035.JPJF01000014_gene4755	7.994e-24	112.0	COG1402@1|root,COG1402@2|Bacteria,1TUPT@1239|Firmicutes,259JU@186801|Clostridia,3Y23Z@572511|Blautia	186801|Clostridia	S	Creatinine amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Creatininase
SX2_k127_226092_3	481448.Minf_1557	8.922e-66	238.0	COG2360@1|root,COG2360@2|Bacteria,46VHR@74201|Verrucomicrobia,37GDI@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
SX2_k127_226092_6	880073.Calab_2522	1.105e-20	96.0	COG0236@1|root,COG0236@2|Bacteria	2|Bacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
SX2_k127_226092_0	880073.Calab_2523	1.619e-249	792.0	COG1042@1|root,COG1042@2|Bacteria,2NNW5@2323|unclassified Bacteria	2|Bacteria	C	synthetase (ADP forming), alpha	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
SX2_k127_226092_2	880073.Calab_2524	2.821e-114	404.0	COG0363@1|root,COG0363@2|Bacteria,2NPPJ@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion	nagB	GO:0003674,GO:0003824,GO:0004342,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006040,GO:0006044,GO:0006046,GO:0006047,GO:0006048,GO:0006054,GO:0006082,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016054,GO:0016787,GO:0016853,GO:0016860,GO:0016861,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0019239,GO:0019262,GO:0019438,GO:0019752,GO:0034641,GO:0034654,GO:0042737,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046348,GO:0046349,GO:0046395,GO:0046483,GO:0055086,GO:0071704,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901362,GO:1901575,GO:1901576	3.1.1.31,3.5.99.6	ko:K01057,ko:K02564	ko00030,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00520,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R00765,R02035	RC00163,RC00537	ko00000,ko00001,ko00002,ko01000	-	-	iZ_1308.Z0825	Glucosamine_iso
SX2_k127_226092_1	880073.Calab_2525	7.117e-147	480.0	COG1208@1|root,COG1208@2|Bacteria	2|Bacteria	JM	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon	-	-	-	-	-	-	-	-	-	-	-	-	DUF4954,Hexapep
SX2_k127_2295914_0	1499967.BAYZ01000030_gene1190	5.467e-131	426.0	COG4158@1|root,COG4158@2|Bacteria	2|Bacteria	T	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
SX2_k127_2295914_1	1499967.BAYZ01000030_gene1191	9.669e-110	360.0	COG1129@1|root,COG1129@2|Bacteria,2NPR8@2323|unclassified Bacteria	2|Bacteria	G	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
SX2_k127_2295914_3	697281.Mahau_1339	3.201e-67	244.0	COG0407@1|root,COG0407@2|Bacteria,1V4YU@1239|Firmicutes,24FCZ@186801|Clostridia,42HY1@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
SX2_k127_2295914_2	545695.TREAZ_0310	1.462e-74	258.0	COG1801@1|root,COG1801@2|Bacteria,2J5GQ@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
SX2_k127_2316316_1	926569.ANT_05540	3.098e-50	184.0	COG1363@1|root,COG1363@2|Bacteria,2G6EE@200795|Chloroflexi	200795|Chloroflexi	G	peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
SX2_k127_2316316_0	867903.ThesuDRAFT_01176	1.305e-89	306.0	COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,248D0@186801|Clostridia	186801|Clostridia	G	M42 glutamyl aminopeptidase	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Peptidase_M42
SX2_k127_2322320_7	1037409.BJ6T_80850	2.089e-11	68.0	COG0068@1|root,COG0298@1|root,COG0068@2|Bacteria,COG0298@2|Bacteria,1MVP8@1224|Proteobacteria,2TR2N@28211|Alphaproteobacteria,3JW79@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide	hypF	-	-	ko:K04653,ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
SX2_k127_2322320_2	1079986.JH164861_gene7312	4.771e-167	576.0	COG0068@1|root,COG0068@2|Bacteria,2GJYF@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
SX2_k127_2322320_5	234267.Acid_1828	5.036e-37	161.0	COG1874@1|root,COG1874@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	GHL6,Glyco_hydro_42M
SX2_k127_2322320_0	696281.Desru_2877	2.922e-252	822.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,260DJ@186807|Peptococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SX2_k127_2322320_1	1196323.ALKF01000177_gene1074	1.247e-233	739.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,4H9SC@91061|Bacilli,26QMC@186822|Paenibacillaceae	91061|Bacilli	V	ABC transporter, ATP-binding protein	yfiB	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SX2_k127_2322320_8	1382356.JQMP01000003_gene1537	1.551e-10	68.0	COG1846@1|root,COG1846@2|Bacteria,2G7D6@200795|Chloroflexi,27Z9E@189775|Thermomicrobia	189775|Thermomicrobia	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
SX2_k127_2322320_6	529709.PYCH_06410	8.504e-27	114.0	COG0375@1|root,arCOG04426@2157|Archaea,2Y1HT@28890|Euryarchaeota,2440E@183968|Thermococci	183968|Thermococci	S	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
SX2_k127_2322320_4	69014.TK2007	8.579e-41	167.0	COG0489@1|root,arCOG00585@2157|Archaea,2Y2C0@28890|Euryarchaeota,24314@183968|Thermococci	183968|Thermococci	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	ParA
SX2_k127_2322320_3	1069080.KB913028_gene169	1.281e-41	171.0	COG0811@1|root,COG0811@2|Bacteria,1V9M0@1239|Firmicutes	1239|Firmicutes	U	MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
SX2_k127_2322320_9	522772.Dacet_0828	9.535e-09	66.0	COG0848@1|root,COG0848@2|Bacteria	2|Bacteria	U	biopolymer transport protein	exbD	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
SX2_k127_2339978_7	1123274.KB899409_gene551	7.238e-07	51.0	COG0402@1|root,COG0402@2|Bacteria,2J6KS@203691|Spirochaetes	203691|Spirochaetes	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
SX2_k127_2339978_4	1121440.AUMA01000008_gene860	5.009e-56	213.0	COG1835@1|root,COG1835@2|Bacteria,1MYXY@1224|Proteobacteria,42VFT@68525|delta/epsilon subdivisions,2WRGM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
SX2_k127_2339978_0	383372.Rcas_2768	2.701e-183	586.0	COG4030@1|root,COG4030@2|Bacteria,2G67Q@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF2961)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2961
SX2_k127_2339978_2	309799.DICTH_1664	5.557e-118	389.0	COG1638@1|root,COG1638@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	-	-	-	-	-	-	-	-	-	DctP
SX2_k127_2339978_5	1009370.ALO_11184	4.485e-47	175.0	COG3090@1|root,COG3090@2|Bacteria,1VGHS@1239|Firmicutes	1239|Firmicutes	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
SX2_k127_2339978_1	1009370.ALO_11179	9.569e-172	550.0	COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,4H1VX@909932|Negativicutes	909932|Negativicutes	G	transporter, DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
SX2_k127_2339978_3	665571.STHERM_c04230	1.137e-56	205.0	COG1802@1|root,COG1802@2|Bacteria,2J8MW@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, gntR family	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
SX2_k127_2339978_6	383372.Rcas_4230	1.054e-07	54.0	COG3548@1|root,COG3548@2|Bacteria,2G9XI@200795|Chloroflexi,377QW@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function (DUF1211)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
SX2_k127_2343504_3	889378.Spiaf_0586	5.044e-38	162.0	COG4399@1|root,COG4399@2|Bacteria,2JAAN@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF445
SX2_k127_2343504_4	573413.Spirs_2307	2.012e-16	87.0	COG3103@1|root,COG3103@2|Bacteria	2|Bacteria	T	Sh3 type 3 domain protein	yrvJ	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	3.5.1.28	ko:K01448,ko:K05772,ko:K06385	ko01503,ko02010,map01503,map02010	M00186,M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02000,ko03036	3.A.1.6.2,3.A.1.6.4	-	-	AMIN,Amidase_3,SH3_3,SLH
SX2_k127_2343504_0	573413.Spirs_2331	1.907e-284	905.0	COG0556@1|root,COG0556@2|Bacteria,2J57B@203691|Spirochaetes	203691|Spirochaetes	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
SX2_k127_2343504_2	665571.STHERM_c05270	9.315e-123	406.0	COG0265@1|root,COG0265@2|Bacteria,2J6JY@203691|Spirochaetes	203691|Spirochaetes	O	COGs COG0265 Trypsin-like serine protease typically periplasmic contain C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
SX2_k127_2343504_1	589865.DaAHT2_1394	5.167e-131	434.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,42NBJ@68525|delta/epsilon subdivisions,2WJ52@28221|Deltaproteobacteria,2MHQI@213118|Desulfobacterales	28221|Deltaproteobacteria	O	chelatase, subunit ChlI	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
SX2_k127_234840_0	1121440.AUMA01000009_gene600	6.76e-137	459.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42MSQ@68525|delta/epsilon subdivisions,2WISJ@28221|Deltaproteobacteria,2M9XZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK-1	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
SX2_k127_234840_4	1121403.AUCV01000001_gene872	6.323e-81	279.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42M5A@68525|delta/epsilon subdivisions,2WK03@28221|Deltaproteobacteria,2MJNZ@213118|Desulfobacterales	28221|Deltaproteobacteria	E	ABC transporter	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
SX2_k127_234840_5	867903.ThesuDRAFT_01984	1.39e-72	270.0	COG0411@1|root,COG0411@2|Bacteria,1TR0P@1239|Firmicutes,2490B@186801|Clostridia	186801|Clostridia	E	Abc transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
SX2_k127_234840_2	1167006.UWK_00090	8.405e-95	321.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,42TE0@68525|delta/epsilon subdivisions,2WPEP@28221|Deltaproteobacteria,2MKDG@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
SX2_k127_234840_3	589865.DaAHT2_0104	1.545e-93	336.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,42MKP@68525|delta/epsilon subdivisions,2WJU9@28221|Deltaproteobacteria,2MJJN@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
SX2_k127_234840_1	1121403.AUCV01000001_gene868	8.091e-135	439.0	COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,42MXX@68525|delta/epsilon subdivisions,2WKJM@28221|Deltaproteobacteria,2MHQS@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
SX2_k127_2360531_0	204669.Acid345_4390	3.109e-113	395.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y69R@57723|Acidobacteria,2JKIQ@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
SX2_k127_2365113_6	1123274.KB899413_gene833	6.009e-71	243.0	COG0455@1|root,COG0455@2|Bacteria,2J5B7@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the ParA family	fleN	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	AAA_31,CbiA,ParA
SX2_k127_2365113_2	744872.Spica_1524	2.044e-106	359.0	COG1419@1|root,COG1419@2|Bacteria,2J5TV@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar biosynthesis protein FlhF	flhF	-	-	ko:K02404	-	-	-	-	ko00000,ko02035	-	-	-	SRP54
SX2_k127_2365113_0	665571.STHERM_c09300	4.644e-297	925.0	COG1298@1|root,COG1298@2|Bacteria,2J57F@203691|Spirochaetes	203691|Spirochaetes	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
SX2_k127_2365113_1	665571.STHERM_c09290	6.383e-117	400.0	COG1377@1|root,COG1377@2|Bacteria,2J5EU@203691|Spirochaetes	203691|Spirochaetes	N	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhB	-	-	ko:K02401	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_2
SX2_k127_2365113_5	1123274.KB899413_gene837	3.616e-71	253.0	COG1684@1|root,COG1684@2|Bacteria,2J6DD@203691|Spirochaetes	203691|Spirochaetes	N	Role in flagellar biosynthesis	fliR	-	-	ko:K02421	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1
SX2_k127_2365113_7	744872.Spica_1528	3.112e-24	105.0	COG1987@1|root,COG1987@2|Bacteria,2J93G@203691|Spirochaetes	203691|Spirochaetes	N	Role in flagellar biosynthesis	fliQ	-	-	ko:K02420	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_3
SX2_k127_2365113_3	744872.Spica_1529	3.592e-95	321.0	COG1338@1|root,COG1338@2|Bacteria,2J5S9@203691|Spirochaetes	203691|Spirochaetes	N	Plays a role in the flagellum-specific transport system	fliP	-	-	ko:K02419	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliP
SX2_k127_2365113_8	1123274.KB899413_gene840	7.59e-22	104.0	COG3190@1|root,COG3190@2|Bacteria	2|Bacteria	N	flagellar	fliZ	-	-	ko:K02418	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliO
SX2_k127_2365113_4	573413.Spirs_1576	1.039e-87	302.0	COG1776@1|root,COG1886@1|root,COG1776@2|Bacteria,COG1886@2|Bacteria,2J5P8@203691|Spirochaetes	203691|Spirochaetes	N	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliN	-	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FliMN_C
SX2_k127_2405182_0	744872.Spica_2840	7.26e-222	697.0	COG1523@1|root,COG1523@2|Bacteria,2J61K@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
SX2_k127_2405182_1	706587.Desti_0352	0.0003813	53.0	COG3852@1|root,COG3852@2|Bacteria,1QVPN@1224|Proteobacteria,42PS3@68525|delta/epsilon subdivisions,2X7MQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Signal transduction histidine kinase, nitrogen specific	-	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS,PAS_8
SX2_k127_2408126_10	744872.Spica_1252	0.0007844	42.0	COG2426@1|root,COG2426@2|Bacteria,2J7NY@203691|Spirochaetes	203691|Spirochaetes	S	small multi-drug export	-	-	-	-	-	-	-	-	-	-	-	-	Sm_multidrug_ex
SX2_k127_2408126_1	1480694.DC28_02720	3.949e-211	677.0	COG0210@1|root,COG0210@2|Bacteria,2J5T4@203691|Spirochaetes	203691|Spirochaetes	L	DNA helicase	pcrA	-	3.6.4.12	ko:K03656,ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
SX2_k127_2408126_3	889378.Spiaf_0599	6.763e-123	400.0	COG0568@1|root,COG0568@2|Bacteria,2J5M9@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086,ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
SX2_k127_2408126_6	665571.STHERM_c04550	2.586e-38	153.0	29UU7@1|root,30G6P@2|Bacteria,2JB02@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2408126_7	1123274.KB899428_gene1829	7.999e-30	121.0	COG0234@1|root,COG0234@2|Bacteria,2J8BR@203691|Spirochaetes	203691|Spirochaetes	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
SX2_k127_2408126_0	573413.Spirs_1712	3.057e-229	737.0	COG1199@1|root,COG1199@2|Bacteria,2J626@203691|Spirochaetes	203691|Spirochaetes	L	Helicase	dinG	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2,RadC,ResIII
SX2_k127_2408126_4	1480694.DC28_14120	3.557e-74	258.0	COG0005@1|root,COG0005@2|Bacteria,2J8PG@203691|Spirochaetes	203691|Spirochaetes	F	Purine nucleoside	mtnP	-	2.4.2.1,2.4.2.28	ko:K00772,ko:K03783	ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110	M00034	R01402,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
SX2_k127_2408126_9	1218076.BAYB01000009_gene2051	3.358e-09	68.0	COG1893@1|root,COG1893@2|Bacteria,1P0AW@1224|Proteobacteria,2VQ81@28216|Betaproteobacteria,1KGMV@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
SX2_k127_2408126_2	665571.STHERM_c05460	7.123e-137	449.0	COG0527@1|root,COG0527@2|Bacteria,2J6FK@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT_7
SX2_k127_2408126_5	2903.EOD13881	9.307e-39	157.0	COG0253@1|root,2QQKJ@2759|Eukaryota	2759|Eukaryota	E	diaminopimelate epimerase activity	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
SX2_k127_2408126_8	1307761.L21SP2_0923	2.872e-17	89.0	COG2214@1|root,COG2214@2|Bacteria,2J9HD@203691|Spirochaetes	203691|Spirochaetes	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
SX2_k127_2446076_3	1123274.KB899410_gene3538	6.253e-85	304.0	COG0457@1|root,COG0457@2|Bacteria,2J6MS@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_8
SX2_k127_2446076_7	1123274.KB899410_gene3539	9.145e-45	173.0	COG2834@1|root,COG2834@2|Bacteria,2J7JX@203691|Spirochaetes	203691|Spirochaetes	M	PFAM Outer membrane lipoprotein carrier protein LolA	-	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
SX2_k127_2446076_4	573413.Spirs_3759	2.641e-71	257.0	COG1426@1|root,COG1426@2|Bacteria,2J61E@203691|Spirochaetes	203691|Spirochaetes	S	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_25
SX2_k127_2446076_1	545695.TREAZ_2738	2.197e-118	398.0	COG0621@1|root,COG0621@2|Bacteria,2J5PM@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
SX2_k127_2446076_0	889378.Spiaf_0658	1.429e-196	635.0	COG0210@1|root,COG0210@2|Bacteria,2J5EW@203691|Spirochaetes	203691|Spirochaetes	L	DNA helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
SX2_k127_2446076_2	443143.GM18_4141	6.21e-86	291.0	COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,42N4U@68525|delta/epsilon subdivisions,2WJR7@28221|Deltaproteobacteria,43TUX@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Converts GTP to 7,8-dihydroneopterin triphosphate	folE2	-	3.5.4.16	ko:K09007	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GCHY-1
SX2_k127_2446076_8	665571.STHERM_c21200	3.787e-22	106.0	COG0001@1|root,COG0001@2|Bacteria,2J60V@203691|Spirochaetes	203691|Spirochaetes	H	glutamate-1-semialdehyde 2,1-aminomutase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2446076_9	861299.J421_3607	2.62e-21	110.0	COG0363@1|root,COG2120@1|root,COG0363@2|Bacteria,COG2120@2|Bacteria,1ZSQV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	-	-	3.5.99.6	ko:K02564	ko00520,ko01100,map00520,map01100	-	R00765	RC00163	ko00000,ko00001,ko01000	-	-	-	Glucosamine_iso,PIG-L
SX2_k127_2446076_11	247490.KSU1_B0122	1.233e-09	68.0	2DU2S@1|root,33NPR@2|Bacteria,2J4AF@203682|Planctomycetes	203682|Planctomycetes	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_13
SX2_k127_2446076_10	1480694.DC28_10050	2.96e-16	87.0	28WC9@1|root,2ZICM@2|Bacteria,2J8XW@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2446076_5	744872.Spica_0467	3.367e-57	210.0	COG0102@1|root,COG0102@2|Bacteria,2J7C1@203691|Spirochaetes	203691|Spirochaetes	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
SX2_k127_2446076_6	573413.Spirs_3752	1.079e-47	179.0	COG0103@1|root,COG0103@2|Bacteria,2J8A0@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
SX2_k127_2446076_12	266117.Rxyl_1424	3.476e-06	55.0	COG2137@1|root,COG2137@2|Bacteria	2|Bacteria	S	regulation of DNA repair	recX	GO:0003674,GO:0005575,GO:0005623,GO:0005886,GO:0006282,GO:0008150,GO:0016020,GO:0019219,GO:0019222,GO:0030234,GO:0031323,GO:0044464,GO:0048583,GO:0050789,GO:0050790,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0080134,GO:0080135,GO:0098772,GO:2001020	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
SX2_k127_2447226_2	697281.Mahau_1348	7.912e-86	293.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1TQ33@1239|Firmicutes,249TZ@186801|Clostridia,42FCI@68295|Thermoanaerobacterales	186801|Clostridia	L	DNA polymerase	polX	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
SX2_k127_2447226_4	1380354.JIAN01000005_gene1823	9.409e-76	260.0	COG0177@1|root,COG0177@2|Bacteria,2GJ01@201174|Actinobacteria,4F0JA@85016|Cellulomonadaceae	201174|Actinobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
SX2_k127_2447226_7	889378.Spiaf_0474	1.874e-14	85.0	28QN8@1|root,2ZD3W@2|Bacteria,2JBCA@203691|Spirochaetes	203691|Spirochaetes	S	DOMON domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2447226_6	573413.Spirs_0014	1.929e-15	82.0	COG0633@1|root,COG0633@2|Bacteria,2JB6Y@203691|Spirochaetes	203691|Spirochaetes	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2
SX2_k127_2447226_1	665571.STHERM_c05530	6.299e-92	313.0	COG1159@1|root,COG1159@2|Bacteria,2J671@203691|Spirochaetes	203691|Spirochaetes	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
SX2_k127_2447226_0	552811.Dehly_1057	1.201e-92	314.0	COG0005@1|root,COG0005@2|Bacteria,2G5JP@200795|Chloroflexi,34D1X@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtaP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
SX2_k127_2447226_3	744872.Spica_2494	1.637e-78	282.0	COG0740@1|root,COG0740@2|Bacteria,2J78H@203691|Spirochaetes	203691|Spirochaetes	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP-2	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
SX2_k127_2449767_5	1123274.KB899409_gene466	5.617e-06	53.0	28Y5G@1|root,2ZK0U@2|Bacteria,2JB1C@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2449767_2	1499967.BAYZ01000076_gene841	1.139e-101	343.0	COG1453@1|root,COG1453@2|Bacteria	2|Bacteria	S	Aldo/keto reductase family	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
SX2_k127_2449767_4	519989.ECTPHS_09794	2.377e-36	148.0	COG2199@1|root,COG3706@2|Bacteria,1MV4X@1224|Proteobacteria,1S5A8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	GGDEF domain	-	-	2.7.7.65	ko:K21020	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000	-	-	-	GGDEF
SX2_k127_2449767_3	1380391.JIAS01000012_gene3946	1.149e-74	279.0	COG0235@1|root,COG0235@2|Bacteria,1MU54@1224|Proteobacteria,2U2EW@28211|Alphaproteobacteria,2JWIH@204441|Rhodospirillales	204441|Rhodospirillales	G	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
SX2_k127_2449767_0	1499967.BAYZ01000159_gene498	3.311e-237	753.0	COG1069@1|root,COG1069@2|Bacteria,2NQNS@2323|unclassified Bacteria	2|Bacteria	G	FGGY family of carbohydrate kinases, N-terminal domain	araB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008741,GO:0009056,GO:0009058,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0019569,GO:0019572,GO:0019637,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0046373,GO:0046835,GO:0051167,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901159,GO:1901575,GO:1901576	2.7.1.16	ko:K00853	ko00040,ko01100,map00040,map01100	-	R01526,R02439	RC00002,RC00538	ko00000,ko00001,ko01000	-	-	iBWG_1329.BWG_0059,iECH74115_1262.ECH74115_0068,iECSP_1301.ECSP_0067,iECs_1301.ECs0067,iG2583_1286.G2583_0066,iPC815.YPO2254,iZ_1308.Z0072	FGGY_C,FGGY_N
SX2_k127_2449767_1	1499967.BAYZ01000131_gene362	3.192e-168	535.0	COG2407@1|root,COG2407@2|Bacteria	2|Bacteria	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_Isome,Fucose_iso_C
SX2_k127_2451456_2	1151117.AJLF01000002_gene122	1.364e-14	78.0	COG0498@1|root,arCOG01434@2157|Archaea,2XT84@28890|Euryarchaeota,243IN@183968|Thermococci	183968|Thermococci	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SX2_k127_2451456_0	926550.CLDAP_11470	2.554e-109	370.0	COG1680@1|root,COG1680@2|Bacteria,2G8Z2@200795|Chloroflexi	200795|Chloroflexi	V	Beta-lactamase	-	-	3.5.2.6	ko:K01467	ko01501,ko02020,map01501,map02020	M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000	-	-	-	Beta-lactamase
SX2_k127_2451456_1	665956.HMPREF1032_01292	5.733e-36	138.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,3WMYQ@541000|Ruminococcaceae	186801|Clostridia	P	Oligopeptide/dipeptide transporter, C-terminal region	oppF	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
SX2_k127_2461365_1	1379270.AUXF01000003_gene3511	1.811e-35	144.0	COG0218@1|root,COG0218@2|Bacteria,1ZTHF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
SX2_k127_2461365_0	861299.J421_3856	2.813e-214	670.0	COG1219@1|root,COG1219@2|Bacteria,1ZT8F@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
SX2_k127_2465946_1	909663.KI867150_gene2881	1.003e-71	259.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42QJF@68525|delta/epsilon subdivisions,2WJ9D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,Response_reg
SX2_k127_2465946_4	1123075.AUDP01000032_gene718	7.441e-15	87.0	COG0407@1|root,COG0407@2|Bacteria,1VEQ3@1239|Firmicutes,24RQ2@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX2_k127_2465946_3	876269.ARWA01000001_gene1530	1.42e-22	108.0	COG0745@1|root,COG0745@2|Bacteria,1NWP7@1224|Proteobacteria,2USQ2@28211|Alphaproteobacteria,3NCGG@45404|Beijerinckiaceae	28211|Alphaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
SX2_k127_2465946_2	497321.C664_02180	9.615e-23	113.0	COG0680@1|root,COG0680@2|Bacteria,1MZE1@1224|Proteobacteria,2VTPX@28216|Betaproteobacteria,2KWJ7@206389|Rhodocyclales	206389|Rhodocyclales	C	maturation	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2465946_0	305700.B447_05383	1.601e-140	454.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,2VJT0@28216|Betaproteobacteria,2KVAX@206389|Rhodocyclales	206389|Rhodocyclales	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	hoxH	-	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
SX2_k127_2471673_3	1288484.APCS01000077_gene2067	9.688e-70	257.0	COG0600@1|root,COG1116@1|root,COG0600@2|Bacteria,COG1116@2|Bacteria,1WKW8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran,BPD_transp_1
SX2_k127_2471673_5	926550.CLDAP_00310	1.638e-49	190.0	COG0715@1|root,COG0715@2|Bacteria,2G6E9@200795|Chloroflexi	200795|Chloroflexi	P	PFAM NMT1 THI5 like domain protein	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
SX2_k127_2471673_2	1307761.L21SP2_0117	9.399e-77	267.0	COG3694@1|root,COG3694@2|Bacteria,2J7M7@203691|Spirochaetes	203691|Spirochaetes	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
SX2_k127_2471673_4	1307761.L21SP2_0116	4.884e-62	237.0	COG4587@1|root,COG4587@2|Bacteria,2J8ZR@203691|Spirochaetes	203691|Spirochaetes	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
SX2_k127_2471673_1	1408422.JHYF01000013_gene500	3.429e-114	379.0	COG4586@1|root,COG4586@2|Bacteria,1TP1N@1239|Firmicutes,247KC@186801|Clostridia,36F1A@31979|Clostridiaceae	186801|Clostridia	S	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX2_k127_2471673_7	40571.JOEA01000016_gene116	8.309e-09	64.0	2CIK4@1|root,33N0E@2|Bacteria,2IBGS@201174|Actinobacteria,4E1JM@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2471673_0	665571.STHERM_c18190	2.008e-121	398.0	COG0673@1|root,COG0673@2|Bacteria,2J5J5@203691|Spirochaetes	203691|Spirochaetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
SX2_k127_2471673_6	552811.Dehly_1213	1.001e-45	185.0	COG2211@1|root,COG2211@2|Bacteria,2G8SN@200795|Chloroflexi	200795|Chloroflexi	G	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2471673_8	479431.Namu_1999	0.0003702	53.0	COG1073@1|root,COG1073@2|Bacteria,2IPVI@201174|Actinobacteria	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2474626_8	398767.Glov_3033	5.348e-34	142.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,42YJ3@68525|delta/epsilon subdivisions,2WUQQ@28221|Deltaproteobacteria,43SUN@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Pyridoxal-dependent decarboxylase, C-terminal sheet domain	-	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
SX2_k127_2474626_4	1415774.U728_1923	6.222e-105	354.0	COG1712@1|root,COG1712@2|Bacteria,1TQ4R@1239|Firmicutes,2499V@186801|Clostridia,36DE0@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate	ddh	-	1.4.1.16	ko:K03340	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	M00526	R02755	RC00006	ko00000,ko00001,ko00002,ko01000	-	-	-	DAPDH_C,DapB_N
SX2_k127_2474626_5	1121104.AQXH01000001_gene964	6.515e-103	345.0	COG3804@1|root,COG3804@2|Bacteria	2|Bacteria	-	-	ord	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0047530,GO:0055114,GO:0071704,GO:1901564,GO:1901605	1.4.1.12,1.4.1.16,1.4.1.26	ko:K03340,ko:K21672	ko00300,ko00310,ko00330,ko00472,ko01100,ko01110,ko01230,map00300,map00310,map00330,map00472,map01100,map01110,map01230	M00526	R02755,R02825,R04200,R04201,R04687,R04688	RC00006,RC00249,RC00790	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_N
SX2_k127_2474626_1	469383.Cwoe_0640	9.035e-183	613.0	COG2133@1|root,COG2133@2|Bacteria,2IB3Z@201174|Actinobacteria	201174|Actinobacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2474626_2	1499967.BAYZ01000188_gene3895	1.329e-156	507.0	COG0624@1|root,COG0624@2|Bacteria,2NNX2@2323|unclassified Bacteria	2|Bacteria	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
SX2_k127_2474626_0	1123274.KB899409_gene554	4.794e-248	784.0	COG1529@1|root,COG1529@2|Bacteria,2J59A@203691|Spirochaetes	203691|Spirochaetes	C	Aldehyde oxidase and xanthine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
SX2_k127_2474626_7	1121440.AUMA01000016_gene127	9.463e-43	179.0	COG2080@1|root,COG2080@2|Bacteria,1MWA6@1224|Proteobacteria,42RRP@68525|delta/epsilon subdivisions,2WP0I@28221|Deltaproteobacteria,2MBFY@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM 2Fe-2S -binding	-	-	1.2.5.3	ko:K03518,ko:K13483	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Fer2_2
SX2_k127_2474626_6	573413.Spirs_1391	1.149e-57	215.0	COG1319@1|root,COG1319@2|Bacteria,2J80S@203691|Spirochaetes	203691|Spirochaetes	C	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM	coxM	-	-	-	-	-	-	-	-	-	-	-	CO_deh_flav_C,FAD_binding_5
SX2_k127_2474626_3	926569.ANT_01260	3.668e-118	407.0	COG0549@1|root,COG0549@2|Bacteria,2G6C7@200795|Chloroflexi	200795|Chloroflexi	E	Amino acid kinase family	-	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
SX2_k127_2475592_4	889378.Spiaf_1972	3.116e-07	53.0	COG1080@1|root,COG1080@2|Bacteria,2J5FB@203691|Spirochaetes	203691|Spirochaetes	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
SX2_k127_2475592_0	665571.STHERM_c12980	1.738e-117	398.0	COG1160@1|root,COG1160@2|Bacteria,2J5GG@203691|Spirochaetes	203691|Spirochaetes	I	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
SX2_k127_2475592_3	744872.Spica_2559	3.314e-23	116.0	COG0789@1|root,COG0789@2|Bacteria,2J82G@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator, MerR family	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
SX2_k127_2475592_1	649638.Trad_0907	1.959e-103	365.0	COG4284@1|root,COG4284@2|Bacteria	2|Bacteria	G	Utp--glucose-1-phosphate uridylyltransferase	CP_1013	-	2.7.7.23,2.7.7.83	ko:K00972,ko:K11442	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00361,M00362	R00416	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPGP
SX2_k127_2475592_2	1307761.L21SP2_1346	4.953e-68	253.0	2F2JP@1|root,33VGK@2|Bacteria,2J6EC@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2485381_0	760011.Spico_1795	0.0	1121.0	COG0587@1|root,COG0587@2|Bacteria,2J5B5@203691|Spirochaetes	203691|Spirochaetes	L	DNA-directed DNA polymerase	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
SX2_k127_2485381_1	289376.THEYE_A1986	1.052e-90	329.0	COG0460@1|root,COG0460@2|Bacteria,3J0G1@40117|Nitrospirae	40117|Nitrospirae	E	Homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
SX2_k127_2485381_2	1121406.JAEX01000001_gene477	4.378e-60	233.0	COG1387@1|root,COG1387@2|Bacteria,1R9W5@1224|Proteobacteria,42QNF@68525|delta/epsilon subdivisions,2WMV0@28221|Deltaproteobacteria,2M8EF@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	SMART phosphoesterase PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP
SX2_k127_2485381_4	1307761.L21SP2_1045	1.078e-15	90.0	COG0762@1|root,COG0762@2|Bacteria	2|Bacteria	D	integral membrane protein	ylmG	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
SX2_k127_2485381_3	665571.STHERM_c08070	1.42e-34	152.0	COG1200@1|root,COG1200@2|Bacteria,2J5ET@203691|Spirochaetes	203691|Spirochaetes	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
SX2_k127_2486137_5	545695.TREAZ_0471	0.0001514	48.0	COG1656@1|root,31CR7@2|Bacteria,2J8IW@203691|Spirochaetes	203691|Spirochaetes	S	Mut7-C RNAse domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2486137_0	665571.STHERM_c19420	1.466e-161	533.0	COG0172@1|root,COG0172@2|Bacteria,2J5EM@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
SX2_k127_2486137_1	1123274.KB899412_gene1482	5.033e-48	189.0	COG0345@1|root,COG0345@2|Bacteria,2J6DB@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
SX2_k127_2486137_3	999630.TUZN_1426	4.972e-32	131.0	COG0622@1|root,arCOG01141@2157|Archaea,2XQUM@28889|Crenarchaeota	28889|Crenarchaeota	S	TIGRFAM phosphodiesterase, MJ0936 family	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
SX2_k127_2486137_4	1123274.KB899407_gene188	3.199e-19	90.0	2DFDU@1|root,2ZRHI@2|Bacteria,2J8SZ@203691|Spirochaetes	203691|Spirochaetes	S	factor, FlgM	-	-	-	ko:K02398	ko02020,ko02025,ko02026,ko02040,map02020,map02025,map02026,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgM
SX2_k127_2486137_2	744872.Spica_0014	5.965e-35	141.0	COG1454@1|root,COG1454@2|Bacteria,2J5ZT@203691|Spirochaetes	203691|Spirochaetes	C	alcohol dehydrogenase	eutG	-	1.1.1.1	ko:K13954,ko:K19954	ko00010,ko00071,ko00350,ko00625,ko00626,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R04880,R05233,R05234,R06917,R06927	RC00050,RC00088,RC00099,RC00116,RC00649	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
SX2_k127_2503236_3	1480694.DC28_07915	4.577e-56	207.0	COG1752@1|root,COG1752@2|Bacteria,2J6JW@203691|Spirochaetes	203691|Spirochaetes	M	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,Patatin
SX2_k127_2503236_6	161156.JQKW01000013_gene153	9.952e-24	102.0	COG0694@1|root,COG0694@2|Bacteria,2GI0R@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	NifU-like domain	-	-	-	-	-	-	-	-	-	-	-	-	NifU
SX2_k127_2503236_4	690850.Desaf_3320	1.835e-48	177.0	COG2033@1|root,COG2033@2|Bacteria,1QNA5@1224|Proteobacteria,435XP@68525|delta/epsilon subdivisions,2X0EC@28221|Deltaproteobacteria,2MC18@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Desulfoferrodoxin	-	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrodox
SX2_k127_2503236_5	316274.Haur_3795	5.51e-40	160.0	COG1528@1|root,COG1528@2|Bacteria,2G8JG@200795|Chloroflexi,37728@32061|Chloroflexia	32061|Chloroflexia	C	Iron-storage protein	-	-	1.16.3.2	ko:K02217	-	-	-	-	ko00000,ko01000	-	-	-	Ferritin
SX2_k127_2503236_0	1279009.ADICEAN_00534	2.692e-142	468.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	isp	-	-	ko:K13275	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	Peptidase_S8
SX2_k127_2503236_2	211165.AJLN01000066_gene4475	2.208e-65	235.0	COG0561@1|root,COG0561@2|Bacteria,1GDI4@1117|Cyanobacteria	1117|Cyanobacteria	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
SX2_k127_2503236_7	883080.HMPREF9697_02507	0.0002695	52.0	COG0697@1|root,COG0697@2|Bacteria,1RCED@1224|Proteobacteria,2U66Q@28211|Alphaproteobacteria,3K515@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SX2_k127_2503236_1	644966.Tmar_1692	2.403e-95	325.0	COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,24BAN@186801|Clostridia	186801|Clostridia	G	M42 glutamyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
SX2_k127_2513344_3	1209989.TepiRe1_0846	8.657e-62	214.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,42FJK@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033,ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
SX2_k127_2513344_1	865861.AZSU01000004_gene1043	4.851e-137	449.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,24D3Z@186801|Clostridia,36HX5@31979|Clostridiaceae	186801|Clostridia	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
SX2_k127_2513344_0	865861.AZSU01000004_gene1044	9.862e-147	488.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,36DZS@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
SX2_k127_2513344_2	865861.AZSU01000004_gene1045	1.701e-75	268.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,36EGD@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the ABC transporter superfamily	oppF	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
SX2_k127_2513381_2	1123274.KB899408_gene3928	7.408e-53	201.0	COG2209@1|root,COG2209@2|Bacteria,2JA3V@203691|Spirochaetes	203691|Spirochaetes	C	Rnf-Nqr subunit, membrane protein	-	-	1.6.5.8	ko:K00350	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
SX2_k127_2513381_1	573413.Spirs_0596	1.963e-74	262.0	COG1347@1|root,COG1347@2|Bacteria,2J9XG@203691|Spirochaetes	203691|Spirochaetes	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	-	-	1.6.5.8	ko:K00349	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
SX2_k127_2513381_3	573413.Spirs_0595	3.709e-33	143.0	COG2869@1|root,COG2869@2|Bacteria,2JBGM@203691|Spirochaetes	203691|Spirochaetes	C	FMN_bind	-	-	1.6.5.8	ko:K00348	-	-	-	-	ko00000,ko01000	-	-	-	FMN_bind
SX2_k127_2513381_0	1123274.KB899408_gene3925	2.455e-101	340.0	COG4658@1|root,COG4658@2|Bacteria,2J9NA@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the NqrB RnfD family	-	-	1.6.5.8	ko:K00347	-	-	-	-	ko00000,ko01000	-	-	-	NQR2_RnfD_RnfE
SX2_k127_2513381_4	196162.Noca_2375	8.193e-09	66.0	COG2115@1|root,COG2115@2|Bacteria,2GJCA@201174|Actinobacteria,4DP79@85009|Propionibacteriales	201174|Actinobacteria	G	Xylose isomerase-like TIM barrel	xylA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0071704,GO:1901575	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
SX2_k127_2521533_1	1381123.AYOD01000054_gene427	3.708e-27	117.0	COG0745@1|root,COG3920@1|root,COG0745@2|Bacteria,COG3920@2|Bacteria,1MVPJ@1224|Proteobacteria,2TSSQ@28211|Alphaproteobacteria,43IME@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	Histidine kinase-like ATPase domain	fsrR	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2,HisKA_2,Response_reg
SX2_k127_2521533_0	1125863.JAFN01000001_gene2253	6.207e-122	406.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
SX2_k127_2522605_2	264732.Moth_1713	1.676e-65	230.0	COG3829@1|root,COG4624@1|root,COG3829@2|Bacteria,COG4624@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,42F02@68295|Thermoanaerobacterales	186801|Clostridia	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fe_hyd_lg_C,Fer4,HTH_8,PAS,PAS_4,PAS_9,PTS-HPr,Sigma54_activat
SX2_k127_2522605_1	573413.Spirs_0474	5.187e-238	745.0	COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,2J6JA@203691|Spirochaetes	203691|Spirochaetes	C	PFAM Iron only hydrogenase large subunit, C-terminal domain	-	-	1.12.1.3,1.17.99.7,1.6.5.3	ko:K00336,ko:K18332,ko:K22015	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
SX2_k127_2522605_8	349161.Dred_1651	4.767e-20	91.0	COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,1TP6C@1239|Firmicutes,24897@186801|Clostridia,2610M@186807|Peptococcaceae	186801|Clostridia	C	iron hydrogenase, small subunit	-	-	1.12.1.3,1.6.5.3	ko:K00336,ko:K18332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_7,Fer4_9,NADH-G_4Fe-4S_3
SX2_k127_2522605_0	1480694.DC28_06435	0.0	1183.0	COG0493@1|root,COG1894@1|root,COG0493@2|Bacteria,COG1894@2|Bacteria,2J5W1@203691|Spirochaetes	203691|Spirochaetes	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4_20,NADH_4Fe-4S,Pyr_redox_2,SLBB
SX2_k127_2522605_9	903814.ELI_0845	2.038e-19	100.0	COG3411@1|root,COG3411@2|Bacteria,1V6DT@1239|Firmicutes,24M31@186801|Clostridia,25X30@186806|Eubacteriaceae	186801|Clostridia	C	Ferredoxin	-	-	1.12.1.3	ko:K17992	-	-	-	-	ko00000,ko01000	-	-	-	2Fe-2S_thioredx
SX2_k127_2522605_3	573413.Spirs_0476	1.326e-56	205.0	COG1905@1|root,COG1905@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
SX2_k127_2522605_7	1235835.C814_02717	2.173e-26	117.0	COG4191@1|root,COG4191@2|Bacteria,1V6MN@1239|Firmicutes,24JDQ@186801|Clostridia,3WIWP@541000|Ruminococcaceae	186801|Clostridia	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
SX2_k127_2522605_5	644282.Deba_1522	1.758e-34	146.0	COG0613@1|root,COG0613@2|Bacteria,1N68X@1224|Proteobacteria,42TYN@68525|delta/epsilon subdivisions,2WR34@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PHP-associated	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP_C
SX2_k127_2522605_10	574087.Acear_1812	2.29e-10	74.0	COG4109@1|root,COG4109@2|Bacteria,1UK26@1239|Firmicutes,25FMI@186801|Clostridia	186801|Clostridia	K	PFAM DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
SX2_k127_2522605_6	1121468.AUBR01000009_gene2109	1.568e-28	133.0	COG2000@1|root,COG2221@1|root,COG4624@1|root,COG2000@2|Bacteria,COG2221@2|Bacteria,COG4624@2|Bacteria,1TRB4@1239|Firmicutes,24BF5@186801|Clostridia,42F1E@68295|Thermoanaerobacterales	186801|Clostridia	C	Fe-S cluster domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fe_hyd_lg_C,Fer4,Fer4_10,Fer4_9
SX2_k127_2522605_4	926567.TheveDRAFT_1106	1.875e-36	158.0	COG2172@1|root,COG2172@2|Bacteria,3TB7G@508458|Synergistetes	508458|Synergistetes	T	anti-sigma regulatory factor	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2
SX2_k127_2522605_11	584708.Apau_1101	1.472e-07	59.0	COG4109@1|root,COG4109@2|Bacteria,3TBCK@508458|Synergistetes	508458|Synergistetes	K	PFAM DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
SX2_k127_259382_2	744872.Spica_1656	2.868e-47	188.0	COG2185@1|root,COG2185@2|Bacteria,2J83G@203691|Spirochaetes	203691|Spirochaetes	I	Catalyzes the carbon skeleton rearrangement of L- glutamate to L-threo-3-methylaspartate ((2S,3S)-3- methylaspartate)	mamA	-	5.4.99.1	ko:K01846	ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200	M00740	R00262	RC01221	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
SX2_k127_259382_0	744872.Spica_1655	3.855e-75	264.0	COG2188@1|root,COG2188@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
SX2_k127_259382_3	1307761.L21SP2_3480	2.563e-36	155.0	COG0457@1|root,COG0457@2|Bacteria,2J7YH@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_259382_4	1307761.L21SP2_3480	1.374e-10	74.0	COG0457@1|root,COG0457@2|Bacteria,2J7YH@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_259382_1	395963.Bind_0620	4.132e-52	189.0	COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,2TTVF@28211|Alphaproteobacteria,3NCC8@45404|Beijerinckiaceae	28211|Alphaproteobacteria	IQ	KR domain	-	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
SX2_k127_2597808_7	997296.PB1_12739	1.117e-31	131.0	COG0584@1|root,COG0584@2|Bacteria,1UGF1@1239|Firmicutes,4H9QE@91061|Bacilli,1ZPVG@1386|Bacillus	91061|Bacilli	C	Glycerophosphoryl diester phosphodiesterase family	glpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	DUF1080,GDPD
SX2_k127_2597808_0	158190.SpiGrapes_0062	3.41e-151	504.0	COG1653@1|root,COG1653@2|Bacteria,2J8MG@203691|Spirochaetes	203691|Spirochaetes	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K05813	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	SBP_bac_8
SX2_k127_2597808_2	158190.SpiGrapes_0063	5.18e-125	407.0	COG0395@1|root,COG0395@2|Bacteria,2J7VD@203691|Spirochaetes	203691|Spirochaetes	P	ABC transporter, permease protein	-	-	-	ko:K02026,ko:K17246	ko02010,map02010	M00207,M00601	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.40	-	-	BPD_transp_1
SX2_k127_2597808_1	158190.SpiGrapes_0064	7.05e-130	421.0	COG1175@1|root,COG1175@2|Bacteria,2J5Q4@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025,ko:K05814	ko02010,map02010	M00198,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.3	-	-	BPD_transp_1
SX2_k127_2597808_6	861299.J421_4367	6.399e-34	139.0	COG1051@1|root,COG1051@2|Bacteria,1ZU0E@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
SX2_k127_2597808_4	570952.ATVH01000015_gene1437	2.178e-58	211.0	COG1335@1|root,COG1335@2|Bacteria,1QK2B@1224|Proteobacteria,2U5X9@28211|Alphaproteobacteria,2JTV0@204441|Rhodospirillales	204441|Rhodospirillales	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
SX2_k127_2597808_8	1123060.JONP01000009_gene2136	1.418e-24	111.0	COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,2TUVZ@28211|Alphaproteobacteria,2JZMQ@204441|Rhodospirillales	204441|Rhodospirillales	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
SX2_k127_2597808_3	1122963.AUHB01000001_gene306	2.433e-102	364.0	COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,2TQJV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
SX2_k127_2597808_5	97139.C824_01933	4.987e-37	151.0	COG1879@1|root,COG1879@2|Bacteria,1V607@1239|Firmicutes,24G4K@186801|Clostridia,36S34@31979|Clostridiaceae	186801|Clostridia	G	Periplasmic binding proteins and sugar binding domain of LacI family	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
SX2_k127_2605626_1	573413.Spirs_2542	2.119e-43	168.0	COG2199@1|root,COG3706@2|Bacteria,2J8YI@203691|Spirochaetes	203691|Spirochaetes	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2605626_0	744872.Spica_1619	2.952e-80	281.0	2F8HF@1|root,340W9@2|Bacteria,2J5EY@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2608079_0	665571.STHERM_c07150	6.241e-265	839.0	COG5009@1|root,COG5009@2|Bacteria,2J5D4@203691|Spirochaetes	203691|Spirochaetes	M	penicillin-binding protein	pbp-3	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
SX2_k127_2608079_6	670487.Ocepr_1642	2.256e-33	136.0	COG0509@1|root,COG0509@2|Bacteria,1WJYK@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
SX2_k127_2608079_3	1480694.DC28_11120	3.13e-86	302.0	COG1475@1|root,COG1475@2|Bacteria,2J6CV@203691|Spirochaetes	203691|Spirochaetes	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2608079_4	1123274.KB899424_gene3006	9.122e-78	267.0	COG2129@1|root,COG2129@2|Bacteria,2J5J9@203691|Spirochaetes	203691|Spirochaetes	S	metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
SX2_k127_2608079_5	545695.TREAZ_0966	7.721e-35	143.0	COG0457@1|root,COG0457@2|Bacteria,2J7SI@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_19,TPR_7,TPR_8
SX2_k127_2608079_2	573413.Spirs_2362	1.405e-106	377.0	COG0457@1|root,COG0457@2|Bacteria,2J5NB@203691|Spirochaetes	203691|Spirochaetes	S	tetratricopeptide repeat	lmp1	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_6,TPR_7,TPR_8
SX2_k127_2608079_7	665571.STHERM_c06630	6.109e-11	64.0	COG0323@1|root,COG0323@2|Bacteria,2J5XE@203691|Spirochaetes	203691|Spirochaetes	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
SX2_k127_2608079_1	573413.Spirs_2361	1.735e-107	366.0	COG0323@1|root,COG0323@2|Bacteria,2J5XE@203691|Spirochaetes	203691|Spirochaetes	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
SX2_k127_2653910_3	760011.Spico_1067	2.719e-42	159.0	COG2211@1|root,COG2211@2|Bacteria,2JAUS@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX2_k127_2653910_4	158190.SpiGrapes_2743	8.38e-12	68.0	COG2211@1|root,COG2211@2|Bacteria,2JAUS@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX2_k127_2653910_0	553973.CLOHYLEM_06300	5.826e-88	302.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,248MY@186801|Clostridia,21ZA9@1506553|Lachnoclostridium	186801|Clostridia	E	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
SX2_k127_2653910_1	760568.Desku_1632	2.184e-56	207.0	COG1082@1|root,COG1082@2|Bacteria,1TRXP@1239|Firmicutes,24EWV@186801|Clostridia,262DG@186807|Peptococcaceae	186801|Clostridia	G	Xylose isomerase-like TIM barrel	-	-	-	ko:K22233	ko00562,map00562	-	R11772	-	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
SX2_k127_2653910_2	1382356.JQMP01000004_gene499	2.308e-56	205.0	COG1063@1|root,COG1063@2|Bacteria,2G7NV@200795|Chloroflexi,27Y3N@189775|Thermomicrobia	189775|Thermomicrobia	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
SX2_k127_2670577_2	1048834.TC41_3302	3.694e-09	61.0	COG1475@1|root,COG1475@2|Bacteria,1TP0I@1239|Firmicutes,4HAC6@91061|Bacilli,278Q7@186823|Alicyclobacillaceae	91061|Bacilli	K	Belongs to the ParB family	noc	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
SX2_k127_2670577_1	935863.AWZR01000001_gene1700	1.113e-51	190.0	COG4832@1|root,COG4832@2|Bacteria,1RBGY@1224|Proteobacteria,1SAGB@1236|Gammaproteobacteria,1X8F0@135614|Xanthomonadales	135614|Xanthomonadales	S	GyrI-like small molecule binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
SX2_k127_2670577_0	1121918.ARWE01000001_gene1683	2.932e-103	353.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,42KZG@68525|delta/epsilon subdivisions,2WIQ5@28221|Deltaproteobacteria,43SCX@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Carbamoyl-phosphate synthase small chain, CPSase domain	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
SX2_k127_2685619_5	59538.XP_005975640.1	2.991e-14	76.0	COG1028@1|root,KOG0725@2759|Eukaryota,38H5G@33154|Opisthokonta,3BK2E@33208|Metazoa,3D0KA@33213|Bilateria,48BIW@7711|Chordata,493XD@7742|Vertebrata,3J31D@40674|Mammalia	59538.XP_005975640.1|-	Q	siderophore biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2685619_2	429009.Adeg_1956	5.87e-87	295.0	COG1313@1|root,COG1313@2|Bacteria,1TRUV@1239|Firmicutes,247VW@186801|Clostridia,42FFV@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Radical SAM domain protein	PflX	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
SX2_k127_2685619_6	1122991.BAIZ01000055_gene2622	1.827e-10	63.0	COG0778@1|root,COG0778@2|Bacteria,4NQN2@976|Bacteroidetes,2G2JZ@200643|Bacteroidia	976|Bacteroidetes	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
SX2_k127_2685619_1	926569.ANT_22350	8.163e-89	303.0	COG3394@1|root,COG3394@2|Bacteria,2G6X5@200795|Chloroflexi	200795|Chloroflexi	G	YdjC-like protein	-	-	3.5.1.105	ko:K03478	-	-	-	-	ko00000,ko01000	-	-	-	YdjC
SX2_k127_2685619_0	926569.ANT_22340	2.048e-181	594.0	COG2211@1|root,COG2211@2|Bacteria,2G6RZ@200795|Chloroflexi	200795|Chloroflexi	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX2_k127_2685619_4	573413.Spirs_2558	1.118e-21	98.0	COG2164@1|root,COG2164@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K09143	-	-	-	-	ko00000	-	-	-	Cyclophil_like
SX2_k127_2685619_3	1121405.dsmv_0904	1.799e-68	235.0	COG0519@1|root,COG0519@2|Bacteria,1NR5X@1224|Proteobacteria,42YTH@68525|delta/epsilon subdivisions,2WUIJ@28221|Deltaproteobacteria,2MPU1@213118|Desulfobacterales	28221|Deltaproteobacteria	F	GMP synthase C terminal domain	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GMP_synt_C,NAD_synthase
SX2_k127_268773_1	1480694.DC28_00800	2.623e-29	118.0	COG0052@1|root,COG0052@2|Bacteria,2J5GZ@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
SX2_k127_268773_0	744872.Spica_1414	3.097e-44	168.0	COG0424@1|root,COG0424@2|Bacteria,2J7EA@203691|Spirochaetes	203691|Spirochaetes	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
SX2_k127_268773_3	1184251.TCELL_1111	0.0001122	52.0	COG3379@1|root,arCOG01377@2157|Archaea,2XPVN@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
SX2_k127_2695294_1	357808.RoseRS_3061	6.795e-74	265.0	COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,2GBT4@200795|Chloroflexi,376J7@32061|Chloroflexia	32061|Chloroflexia	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4
SX2_k127_2695294_0	545694.TREPR_2780	6.781e-81	297.0	COG0457@1|root,COG1652@1|root,COG0457@2|Bacteria,COG1652@2|Bacteria,2J7YH@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2695294_2	338966.Ppro_2157	1.016e-35	151.0	COG4932@1|root,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria,42RZP@68525|delta/epsilon subdivisions,2X7KQ@28221|Deltaproteobacteria,43SHG@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2697361_0	1307761.L21SP2_0023	1.374e-143	472.0	COG1640@1|root,COG1640@2|Bacteria,2J62I@203691|Spirochaetes	203691|Spirochaetes	G	4-alpha-glucanotransferase	-	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
SX2_k127_2697361_1	1128421.JAGA01000003_gene2953	5.142e-77	272.0	COG0366@1|root,COG0366@2|Bacteria,2NQQN@2323|unclassified Bacteria	2|Bacteria	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
SX2_k127_271694_1	290397.Adeh_2489	4.166e-46	190.0	COG0585@1|root,COG0585@2|Bacteria	2|Bacteria	J	pseudouridine synthase activity	truD	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
SX2_k127_271694_2	1453500.AT05_08980	1.444e-05	58.0	COG0697@1|root,COG0697@2|Bacteria,4NGWA@976|Bacteroidetes,1HWX9@117743|Flavobacteriia	976|Bacteroidetes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SX2_k127_271694_0	1304880.JAGB01000002_gene2197	1.406e-297	935.0	COG2407@1|root,COG2407@2|Bacteria,1TQ5Q@1239|Firmicutes,248V0@186801|Clostridia	186801|Clostridia	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	fucI	-	5.3.1.25,5.3.1.3	ko:K01818	ko00051,ko01120,map00051,map01120	-	R03163	RC00434	ko00000,ko00001,ko01000	-	-	-	Fucose_iso_C,Fucose_iso_N1,Fucose_iso_N2
SX2_k127_2718820_2	1499967.BAYZ01000131_gene366	2.513e-21	100.0	COG3807@1|root,COG3807@2|Bacteria,2NRZY@2323|unclassified Bacteria	2|Bacteria	S	Src homology 3 domains	yrvJ	-	3.2.1.96,3.4.17.14,3.5.1.28	ko:K01227,ko:K01447,ko:K01448,ko:K06385,ko:K07260,ko:K11060,ko:K11062,ko:K21472	ko00511,ko00550,ko01100,ko01502,ko01503,ko02020,map00511,map00550,map01100,map01502,map01503,map02020	M00651,M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko02042,ko03036	-	-	-	Amidase_3,Glucosaminidase,NLPC_P60,SH3_3,SH3_4
SX2_k127_2718820_0	1499967.BAYZ01000131_gene367	9.236e-66	238.0	COG4783@1|root,COG4783@2|Bacteria,2NP4F@2323|unclassified Bacteria	2|Bacteria	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
SX2_k127_2718820_1	1304872.JAGC01000009_gene118	1.604e-59	227.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,42N5S@68525|delta/epsilon subdivisions,2WIUS@28221|Deltaproteobacteria,2M92Z@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	SMART Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
SX2_k127_2730949_2	1267535.KB906767_gene917	1.625e-72	249.0	COG1915@1|root,COG1915@2|Bacteria,3Y6MM@57723|Acidobacteria	57723|Acidobacteria	S	LOR/SDH bifunctional enzyme conserved region	-	-	-	-	-	-	-	-	-	-	-	-	Saccharop_dh_N
SX2_k127_2730949_0	573413.Spirs_4136	2.598e-213	676.0	COG0016@1|root,COG0016@2|Bacteria,2J63H@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
SX2_k127_2730949_1	665571.STHERM_c21760	4.722e-107	355.0	COG0072@1|root,COG0072@2|Bacteria,2J63Q@203691|Spirochaetes	203691|Spirochaetes	J	Phenylalanyl-tRNA synthetase, beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B5,tRNA-synt_2d,tRNA_bind
SX2_k127_2748120_1	1411685.U062_00801	6.486e-20	98.0	COG2234@1|root,COG2234@2|Bacteria,1R8T8@1224|Proteobacteria	1224|Proteobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
SX2_k127_2748120_0	1480694.DC28_14775	1.071e-145	471.0	COG0124@1|root,COG0124@2|Bacteria,2J5DX@203691|Spirochaetes	203691|Spirochaetes	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
SX2_k127_2767037_11	1195236.CTER_0329	3.925e-15	78.0	COG2608@1|root,COG2836@1|root,COG4633@1|root,COG2608@2|Bacteria,COG2836@2|Bacteria,COG4633@2|Bacteria,1TQ02@1239|Firmicutes,249HC@186801|Clostridia,3WNAJ@541000|Ruminococcaceae	186801|Clostridia	P	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1,DsbD_2,HMA
SX2_k127_2767037_10	933115.GPDM_14371	6.435e-16	80.0	COG2608@1|root,COG2608@2|Bacteria,1VERB@1239|Firmicutes,4HNP0@91061|Bacilli,26G9W@186818|Planococcaceae	91061|Bacilli	P	Copper chaperone	copZ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K07213	ko04978,map04978	-	-	-	ko00000,ko00001	-	-	-	HMA
SX2_k127_2767037_6	588581.Cpap_3186	1.17e-78	273.0	COG0745@1|root,COG0745@2|Bacteria,1U3FH@1239|Firmicutes,248BR@186801|Clostridia	186801|Clostridia	K	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
SX2_k127_2767037_3	720554.Clocl_2210	5.996e-117	392.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
SX2_k127_2767037_7	545695.TREAZ_2097	1.187e-50	206.0	28M3X@1|root,2ZAHZ@2|Bacteria,2JB7I@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2767037_0	1469948.JPNB01000001_gene1226	2.364e-303	952.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,36DJE@31979|Clostridiaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copA	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
SX2_k127_2767037_1	653733.Selin_1859	1.519e-220	689.0	COG2873@1|root,COG2873@2|Bacteria	2|Bacteria	E	o-acetylhomoserine	-	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
SX2_k127_2767037_2	1121468.AUBR01000024_gene3029	6.903e-127	412.0	COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,2497G@186801|Clostridia,42F5Y@68295|Thermoanaerobacterales	186801|Clostridia	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SX2_k127_2767037_9	477974.Daud_1557	4.548e-29	128.0	COG1959@1|root,COG1959@2|Bacteria,1V3QB@1239|Firmicutes,24JIV@186801|Clostridia,261XS@186807|Peptococcaceae	186801|Clostridia	K	transcriptional regulator	iscR	-	-	-	-	-	-	-	-	-	-	-	Rrf2
SX2_k127_2767037_4	1121468.AUBR01000008_gene2063	2.015e-91	321.0	COG0379@1|root,COG0379@2|Bacteria,1TP6R@1239|Firmicutes,247IJ@186801|Clostridia,42F86@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS12020	NadA
SX2_k127_2767037_12	1123487.KB892835_gene3687	3.612e-09	61.0	COG4309@1|root,COG4309@2|Bacteria,1N4MS@1224|Proteobacteria,2VU7H@28216|Betaproteobacteria,2KXFV@206389|Rhodocyclales	206389|Rhodocyclales	S	Uncharacterized conserved protein (DUF2249)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2249
SX2_k127_2767037_5	794903.OPIT5_16000	6.58e-86	299.0	COG3694@1|root,COG3694@2|Bacteria	2|Bacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
SX2_k127_2767037_8	448385.sce6749	9.322e-41	155.0	COG4587@1|root,COG4587@2|Bacteria,1R53T@1224|Proteobacteria	1224|Proteobacteria	S	transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
SX2_k127_2784913_0	1123508.JH636446_gene6369	1.072e-123	407.0	COG3852@1|root,COG4191@1|root,COG3852@2|Bacteria,COG4191@2|Bacteria,2IWUM@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
SX2_k127_2784913_2	1168067.JAGP01000001_gene2210	8.04e-24	111.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_3,TetR_C_4,TetR_N
SX2_k127_2784913_1	518766.Rmar_1777	2.378e-50	194.0	COG1566@1|root,COG1566@2|Bacteria,4PKPZ@976|Bacteroidetes	976|Bacteroidetes	V	HlyD family secretion protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
SX2_k127_279380_0	665571.STHERM_c04540	1.678e-138	448.0	COG0707@1|root,COG0707@2|Bacteria,2J9T2@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_279380_2	573413.Spirs_2271	8.499e-100	354.0	COG0285@1|root,COG0285@2|Bacteria,2J5CZ@203691|Spirochaetes	203691|Spirochaetes	H	TIGRFAM folylpolyglutamate synthase dihydrofolate synthase	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
SX2_k127_279380_3	573413.Spirs_2274	5.281e-95	331.0	COG1293@1|root,COG1293@2|Bacteria,2J61Z@203691|Spirochaetes	203691|Spirochaetes	K	Fibrinogen-binding protein	FbpA	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
SX2_k127_279380_1	96561.Dole_2101	1.754e-137	467.0	COG2414@1|root,COG2414@2|Bacteria,1R8M4@1224|Proteobacteria,42PRY@68525|delta/epsilon subdivisions,2WIS4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.6	ko:K11389	ko00010,ko01100,ko01120,ko01200,ko01230,map00010,map01100,map01120,map01200,map01230	M00001,M00002	R07159	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
SX2_k127_2832666_2	158189.SpiBuddy_1037	1.386e-67	242.0	COG1840@1|root,COG1840@2|Bacteria	2|Bacteria	P	iron ion homeostasis	-	-	-	ko:K02011,ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1,SBP_bac_6
SX2_k127_2832666_1	1089455.MOPEL_041_00220	7.924e-93	317.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4F7QV@85018|Dermatophilaceae	201174|Actinobacteria	E	import. Responsible for energy coupling to the transport system	potA	-	3.6.3.30	ko:K02010,ko:K02052	ko02010,ko02024,map02010,map02024	M00190,M00193	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10,3.A.1.11	-	-	ABC_tran,TOBE_2
SX2_k127_2832666_0	158189.SpiBuddy_1039	1.875e-143	474.0	COG1178@1|root,COG1178@2|Bacteria,2J6G7@203691|Spirochaetes	2|Bacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
SX2_k127_2860791_1	1122223.KB890697_gene998	1.098e-05	48.0	COG1653@1|root,COG1653@2|Bacteria,1WI1U@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K17315	ko02010,map02010	M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.24,3.A.1.1.30	-	-	SBP_bac_1
SX2_k127_2860791_0	1304880.JAGB01000004_gene1379	1.046e-204	655.0	COG1554@1|root,COG1554@2|Bacteria,1UYXZ@1239|Firmicutes,249HP@186801|Clostridia	186801|Clostridia	G	hydrolase, family 65, central catalytic	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2889257_1	867845.KI911784_gene693	1.627e-155	498.0	COG4214@1|root,COG4214@2|Bacteria,2G8H9@200795|Chloroflexi,376ZS@32061|Chloroflexia	32061|Chloroflexia	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10547	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	BPD_transp_2
SX2_k127_2889257_4	665571.STHERM_c07090	2.219e-84	306.0	COG3852@1|root,COG3852@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	glnL	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042578,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051716,GO:0065007,GO:0071704,GO:0140096,GO:1901564	2.7.13.3	ko:K07708,ko:K07710	ko02020,map02020	M00497,M00500	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
SX2_k127_2889257_3	665571.STHERM_c07080	6.632e-132	434.0	COG2204@1|root,COG2204@2|Bacteria,2J5NY@203691|Spirochaetes	2|Bacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K07714,ko:K10941	ko02020,ko02025,ko05111,map02020,map02025,map05111	M00500	-	-	ko00000,ko00001,ko00002,ko02022,ko03000	-	-	-	HTH_8,Response_reg,Sigma54_activat,TPR_12
SX2_k127_2889257_0	665571.STHERM_c07070	3.182e-173	569.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	gtsA	-	-	ko:K17315	ko02010,map02010	M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.24,3.A.1.1.30	-	-	SBP_bac_1,SBP_bac_8
SX2_k127_2889257_2	1123274.KB899429_gene2872	2.759e-134	432.0	COG0013@1|root,COG0013@2|Bacteria,2J5G2@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
SX2_k127_2895511_2	635013.TherJR_2227	2.945e-08	57.0	COG1897@1|root,COG1897@2|Bacteria,1TQVR@1239|Firmicutes,247NP@186801|Clostridia,260HZ@186807|Peptococcaceae	186801|Clostridia	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metAA	-	2.3.1.46	ko:K00651	ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230	M00017	R01777	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS11970	AA_kinase,HTS
SX2_k127_2895511_0	1121324.CLIT_2c02260	1.993e-172	556.0	COG1032@1|root,COG1032@2|Bacteria,1UYAF@1239|Firmicutes,24D1D@186801|Clostridia	186801|Clostridia	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
SX2_k127_2895511_1	1177181.T9A_01467	2.319e-23	112.0	2BZ6D@1|root,2ZC6J@2|Bacteria,1RBC8@1224|Proteobacteria,1S3G8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2907182_2	1499967.BAYZ01000171_gene5566	5.248e-27	114.0	COG1894@1|root,COG1894@2|Bacteria,2NNM1@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	bamH	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_2080	2Fe-2S_thioredx,Complex1_51K,Fer4,Fer4_20,NADH_4Fe-4S,Pyr_redox_2,SLBB
SX2_k127_2907182_0	1499967.BAYZ01000171_gene5565	1.134e-116	392.0	COG1148@1|root,COG1905@1|root,COG1148@2|Bacteria,COG1905@2|Bacteria,2NPSB@2323|unclassified Bacteria	2|Bacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	bamG	-	1.6.5.3,1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K00334,ko:K03388	ko00190,ko00680,ko01100,ko01120,ko01200,map00190,map00680,map01100,map01120,map01200	M00144,M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944,R11945	RC00011,RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Fer4,NAD_binding_8,Pyr_redox_2,Response_reg
SX2_k127_2907182_1	1499967.BAYZ01000171_gene5564	3.444e-61	216.0	COG1150@1|root,COG1150@2|Bacteria,2NQ2K@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	dld	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390,ko:K18930	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_7,Fer4_8
SX2_k127_2907182_3	1499967.BAYZ01000171_gene5563	2.547e-21	94.0	COG0685@1|root,COG0685@2|Bacteria,2NQBB@2323|unclassified Bacteria	2|Bacteria	E	Methylenetetrahydrofolate reductase	metF3	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
SX2_k127_2915646_10	1267533.KB906733_gene3362	1.108e-43	171.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y7E7@57723|Acidobacteria,2JKGS@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
SX2_k127_2915646_12	935557.ATYB01000014_gene1401	2.595e-09	70.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4BIY6@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_19,TPR_8
SX2_k127_2915646_8	485913.Krac_2635	3.946e-53	206.0	COG0457@1|root,COG3629@1|root,COG3899@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG3899@2|Bacteria,2G871@200795|Chloroflexi	200795|Chloroflexi	K	Transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,TPR_12
SX2_k127_2915646_2	1379698.RBG1_1C00001G0608	7.895e-75	279.0	COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K08282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,TPR_16,TPR_2,TPR_8,TolB_N
SX2_k127_2915646_11	111781.Lepto7376_1083	1.926e-10	70.0	COG2114@1|root,COG2804@1|root,COG2114@2|Bacteria,COG2804@2|Bacteria,1G1PT@1117|Cyanobacteria,1H7NV@1150|Oscillatoriales	1117|Cyanobacteria	T	PFAM Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF,Guanylate_cyc,MASE1,PAS,PAS_3
SX2_k127_2915646_9	880072.Desac_2942	7.541e-50	194.0	COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,42QUA@68525|delta/epsilon subdivisions,2WP2A@28221|Deltaproteobacteria,2MRZW@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	PFAM Protein phosphatase 2C	-	-	3.1.3.16	ko:K01090,ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
SX2_k127_2915646_1	357808.RoseRS_3378	1.649e-90	315.0	COG0515@1|root,COG1594@1|root,COG1716@1|root,COG0515@2|Bacteria,COG1594@2|Bacteria,COG1716@2|Bacteria,2G7ZS@200795|Chloroflexi,3757W@32061|Chloroflexia	200795|Chloroflexi	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
SX2_k127_2915646_0	997346.HMPREF9374_3248	1.202e-111	368.0	COG0656@1|root,COG0656@2|Bacteria,1TPM1@1239|Firmicutes,4HARE@91061|Bacilli,27BA5@186824|Thermoactinomycetaceae	91061|Bacilli	S	Aldo/keto reductase family	yvgN	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SX2_k127_2915646_3	595460.RRSWK_05050	6.569e-68	252.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Pur_ac_phosph_N
SX2_k127_2915646_5	796942.HMPREF9623_00375	2.341e-61	236.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
SX2_k127_2915646_6	1232452.BAIB02000010_gene2073	3.369e-59	224.0	COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,2484X@186801|Clostridia,268TR@186813|unclassified Clostridiales	186801|Clostridia	T	Transcriptional regulatory protein, C terminal	srrA_6	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
SX2_k127_2915646_4	595460.RRSWK_05050	4.737e-65	243.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Pur_ac_phosph_N
SX2_k127_2915646_7	593750.Metfor_1047	5.232e-54	196.0	arCOG09580@1|root,arCOG09580@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2949593_2	1321815.HMPREF9193_01854	1.146e-62	217.0	COG0096@1|root,COG0096@2|Bacteria,2J7SM@203691|Spirochaetes	203691|Spirochaetes	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
SX2_k127_2949593_3	1123274.KB899411_gene3098	3.651e-56	201.0	COG0097@1|root,COG0097@2|Bacteria,2J7WB@203691|Spirochaetes	203691|Spirochaetes	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
SX2_k127_2949593_4	744872.Spica_0401	1.099e-40	153.0	COG0256@1|root,COG0256@2|Bacteria,2J7YP@203691|Spirochaetes	203691|Spirochaetes	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
SX2_k127_2949593_1	573413.Spirs_0972	2.1e-68	236.0	COG0098@1|root,COG0098@2|Bacteria,2J60F@203691|Spirochaetes	203691|Spirochaetes	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
SX2_k127_2949593_6	572544.Ilyop_1792	1.194e-10	70.0	COG1841@1|root,COG1841@2|Bacteria,37B10@32066|Fusobacteria	32066|Fusobacteria	J	Ribosomal protein L30p/L7e	rpmD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
SX2_k127_2949593_5	545694.TREPR_1496	3.334e-38	149.0	COG0200@1|root,COG0200@2|Bacteria,2J7ZW@203691|Spirochaetes	203691|Spirochaetes	J	Binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
SX2_k127_2949593_0	573413.Spirs_0975	6.596e-130	429.0	COG0201@1|root,COG0201@2|Bacteria,2J5BH@203691|Spirochaetes	203691|Spirochaetes	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
SX2_k127_2961623_1	889378.Spiaf_1677	1.655e-39	153.0	COG1861@1|root,COG1861@2|Bacteria,2J58C@203691|Spirochaetes	203691|Spirochaetes	M	spore coat polysaccharide biosynthesis protein	spsF	-	-	ko:K07257	-	-	-	-	ko00000	-	-	-	CTP_transf_3,Methyltransf_23
SX2_k127_2961623_0	889378.Spiaf_1676	4.235e-50	195.0	COG2227@1|root,COG2227@2|Bacteria,2JBIU@203691|Spirochaetes	203691|Spirochaetes	H	Methyltransferase domain	ubiG	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
SX2_k127_2980214_0	697281.Mahau_0817	1.753e-167	546.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,42EN1@68295|Thermoanaerobacterales	186801|Clostridia	C	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
SX2_k127_2980214_9	545694.TREPR_0070	1.13e-09	72.0	2FHVS@1|root,349NX@2|Bacteria,2JBFM@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2980214_7	272563.CD630_33681	1.884e-42	160.0	COG1162@1|root,COG1162@2|Bacteria,1V272@1239|Firmicutes,24CIG@186801|Clostridia	186801|Clostridia	S	RNHCP domain	-	-	-	-	-	-	-	-	-	-	-	-	RNHCP,RsgA_GTPase
SX2_k127_2980214_3	251221.35214018	4.496e-75	267.0	COG1162@1|root,COG1162@2|Bacteria,1G18W@1117|Cyanobacteria	1117|Cyanobacteria	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	-	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
SX2_k127_2980214_5	1316936.K678_14969	4.232e-60	235.0	COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,2TS69@28211|Alphaproteobacteria,2JYVY@204441|Rhodospirillales	204441|Rhodospirillales	T	COG0642 Signal transduction histidine kinase	-	-	2.7.13.3	ko:K14980	ko02020,map02020	M00520	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,Sensor_TM1,Stimulus_sens_1
SX2_k127_2980214_4	1379701.JPJC01000013_gene222	9.113e-64	231.0	COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,2TR43@28211|Alphaproteobacteria,2JZVH@204457|Sphingomonadales	204457|Sphingomonadales	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K14981	ko02020,map02020	M00520	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SX2_k127_2980214_2	1123278.KB893500_gene229	1.703e-90	316.0	COG4452@1|root,COG4452@2|Bacteria,4NGKY@976|Bacteroidetes,47NWS@768503|Cytophagia	976|Bacteroidetes	V	Inner membrane protein CreD	creD	-	-	ko:K06143	-	-	-	-	ko00000	-	-	-	CreD
SX2_k127_2980214_1	1499967.BAYZ01000039_gene2211	1.39e-94	334.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	pqqE	GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0018130,GO:0018189,GO:0018193,GO:0018212,GO:0019538,GO:0019752,GO:0034641,GO:0036211,GO:0042180,GO:0042181,GO:0042364,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072350,GO:0072351,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901661,GO:1901663	-	ko:K06139	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
SX2_k127_2980214_8	203119.Cthe_0232	7.76e-15	87.0	2CEJC@1|root,32R1S@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_3000894_0	665571.STHERM_c15810	4.547e-285	898.0	COG1643@1|root,COG1643@2|Bacteria,2J58M@203691|Spirochaetes	203691|Spirochaetes	L	Helicase	hrpA	-	-	-	-	-	-	-	-	-	-	-	DEAD,HA2,Helicase_C,OB_NTP_bind
SX2_k127_3000894_1	502025.Hoch_5472	2.222e-49	184.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,42MWJ@68525|delta/epsilon subdivisions,2WJ8Q@28221|Deltaproteobacteria,2YYM7@29|Myxococcales	28221|Deltaproteobacteria	O	Belongs to the ClpX chaperone family	-	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small
SX2_k127_30062_3	545695.TREAZ_1874	7.213e-27	114.0	COG1934@1|root,COG1934@2|Bacteria,2J7U8@203691|Spirochaetes	203691|Spirochaetes	S	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm	-	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
SX2_k127_30062_1	665571.STHERM_c21930	4.211e-102	343.0	COG1137@1|root,COG1137@2|Bacteria,2J5CM@203691|Spirochaetes	203691|Spirochaetes	S	ABC transporter, ATP-binding protein	lptB	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
SX2_k127_30062_0	744872.Spica_2731	1.533e-135	452.0	COG1508@1|root,COG1508@2|Bacteria,2J5KV@203691|Spirochaetes	203691|Spirochaetes	K	RNA polymerase sigma54 factor	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
SX2_k127_30062_4	744872.Spica_2730	5.717e-16	91.0	COG1544@1|root,COG1544@2|Bacteria,2J8GG@203691|Spirochaetes	203691|Spirochaetes	J	Ribosomal subunit interface protein	raiA	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosomal_S30AE
SX2_k127_30062_2	1321815.HMPREF9193_00295	2.062e-40	160.0	COG1493@1|root,COG1493@2|Bacteria,2J5JA@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
SX2_k127_3008886_0	1480694.DC28_14140	8.448e-190	627.0	COG2204@1|root,COG2204@2|Bacteria,2J5NY@203691|Spirochaetes	203691|Spirochaetes	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	rrp-2	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
SX2_k127_3008886_1	1307761.L21SP2_0921	4.051e-122	422.0	COG5000@1|root,COG5000@2|Bacteria,2J5RG@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8
SX2_k127_3008886_7	573413.Spirs_1707	3.608e-60	229.0	COG0470@1|root,COG0470@2|Bacteria,2JBGE@203691|Spirochaetes	203691|Spirochaetes	L	DNA polymerase III, delta subunit	-	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2
SX2_k127_3008886_3	545695.TREAZ_0089	8.123e-86	302.0	COG0707@1|root,COG0707@2|Bacteria,2J5XF@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
SX2_k127_3008886_8	665571.STHERM_c05400	2.063e-18	101.0	2FJEQ@1|root,34B4E@2|Bacteria,2J8EB@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_3008886_4	1121381.JNIV01000044_gene1823	3.857e-80	284.0	COG4143@1|root,COG4143@2|Bacteria,1WID6@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	TIGRFAM ABC transporter, periplasmic binding protein, thiB subfamily	-	-	-	ko:K02064	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	SBP_bac_6
SX2_k127_3008886_2	996637.SGM_1896	1.006e-113	392.0	COG1178@1|root,COG1178@2|Bacteria,2GKDH@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type Fe3 transport system permease component	thiP	-	-	ko:K02011,ko:K02063	ko02010,map02010	M00190,M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10,3.A.1.19	-	-	BPD_transp_1
SX2_k127_3008886_5	397278.JOJN01000002_gene419	5.868e-67	257.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4DPQS@85009|Propionibacteriales	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	fbpC	-	-	ko:K02052,ko:K02062	ko02010,ko02024,map02010,map02024	M00191,M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11,3.A.1.19	-	-	ABC_tran,TOBE_2
SX2_k127_3008886_6	1123274.KB899413_gene730	2.292e-64	229.0	COG2199@1|root,COG3706@2|Bacteria,2J9QT@203691|Spirochaetes	203691|Spirochaetes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
SX2_k127_3023174_3	1121403.AUCV01000002_gene576	2.638e-55	206.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2WJBC@28221|Deltaproteobacteria,2MIKT@213118|Desulfobacterales	28221|Deltaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	-	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_topoisoIV
SX2_k127_3023174_2	748247.AZKH_4546	4.348e-78	267.0	COG1573@1|root,COG1573@2|Bacteria,1PIX8@1224|Proteobacteria,2VKZ8@28216|Betaproteobacteria,2KU6J@206389|Rhodocyclales	206389|Rhodocyclales	L	PFAM Uracil-DNA glycosylase superfamily	smuG	-	-	ko:K10800	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
SX2_k127_3023174_7	935866.JAER01000026_gene3160	1.181e-06	61.0	COG5621@1|root,COG5621@2|Bacteria,2GNHM@201174|Actinobacteria	201174|Actinobacteria	S	secreted hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CrtC
SX2_k127_3023174_0	1123274.KB899412_gene1424	1.71e-180	576.0	COG1486@1|root,COG1486@2|Bacteria,2J688@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Glycoside hydrolase, family 4	-	-	3.2.1.22	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
SX2_k127_3023174_1	332101.JIBU02000025_gene3209	4.441e-103	355.0	COG0348@1|root,COG0348@2|Bacteria,1VVUA@1239|Firmicutes,24C27@186801|Clostridia,36FBA@31979|Clostridiaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Fer4_5
SX2_k127_3023174_4	398512.JQKC01000032_gene4478	1.914e-37	149.0	COG2836@1|root,COG2836@2|Bacteria,1VXKF@1239|Firmicutes,24ERT@186801|Clostridia	186801|Clostridia	S	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD_2
SX2_k127_3023174_6	1480694.DC28_15420	3.677e-08	55.0	COG1055@1|root,COG1055@2|Bacteria,2J6QU@203691|Spirochaetes	203691|Spirochaetes	P	Arsenical pump membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp
SX2_k127_3043349_3	640511.BC1002_6699	1.904e-24	109.0	COG1032@1|root,COG1032@2|Bacteria,1R92G@1224|Proteobacteria,2WB71@28216|Betaproteobacteria,1K09Q@119060|Burkholderiaceae	28216|Betaproteobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
SX2_k127_3043349_1	1499967.BAYZ01000033_gene1105	1.028e-38	152.0	COG0655@1|root,COG0655@2|Bacteria	2|Bacteria	S	NAD(P)H dehydrogenase (quinone) activity	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
SX2_k127_3043349_0	1166018.FAES_3728	1.136e-72	260.0	COG4225@1|root,COG4225@2|Bacteria,4NFWI@976|Bacteroidetes,47MS0@768503|Cytophagia	976|Bacteroidetes	V	Glycosyl Hydrolase Family 88	-	-	3.2.1.172	ko:K15532	-	-	-	-	ko00000,ko01000	-	GH105	-	Glyco_hydro_88
SX2_k127_3043349_2	158189.SpiBuddy_2623	1.67e-37	147.0	COG1653@1|root,COG1653@2|Bacteria,2J66Q@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Bacterial extracellular solute-binding	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_1,SBP_bac_8
SX2_k127_3044627_0	909663.KI867150_gene718	3.501e-130	420.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42M9N@68525|delta/epsilon subdivisions,2WIZR@28221|Deltaproteobacteria,2MRAN@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
SX2_k127_3044627_3	96561.Dole_2002	3e-22	102.0	COG3090@1|root,COG3090@2|Bacteria,1N9EF@1224|Proteobacteria,42WJB@68525|delta/epsilon subdivisions,2WRDN@28221|Deltaproteobacteria,2MQ0S@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM Tripartite ATP-independent periplasmic	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
SX2_k127_3044627_1	706587.Desti_0319	2.48e-128	421.0	COG1638@1|root,COG1638@2|Bacteria,1MVHI@1224|Proteobacteria,42MVD@68525|delta/epsilon subdivisions,2WIY3@28221|Deltaproteobacteria,2MR71@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
SX2_k127_3044627_2	1250232.JQNJ01000001_gene2056	6.428e-55	200.0	COG2304@1|root,COG2304@2|Bacteria,4NEGD@976|Bacteroidetes,1HY72@117743|Flavobacteriia	976|Bacteroidetes	P	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA
SX2_k127_3053179_4	926554.KI912654_gene4451	1.019e-38	154.0	COG1070@1|root,COG1070@2|Bacteria,1WJ9Z@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	FGGY family of carbohydrate kinases, N-terminal domain	-	-	2.7.1.5	ko:K00848	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01902,R03014	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
SX2_k127_3053179_1	395019.Bmul_3326	7.557e-102	349.0	COG1680@1|root,COG1680@2|Bacteria,1MY4Y@1224|Proteobacteria,2VRGQ@28216|Betaproteobacteria,1K6IJ@119060|Burkholderiaceae	28216|Betaproteobacteria	V	PFAM beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SX2_k127_3053179_3	1499967.BAYZ01000171_gene5550	8.189e-51	184.0	COG1633@1|root,COG1633@2|Bacteria,2NS04@2323|unclassified Bacteria	2|Bacteria	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
SX2_k127_3053179_0	1499967.BAYZ01000171_gene5554	2.762e-122	411.0	COG0543@1|root,COG0543@2|Bacteria,2NPFH@2323|unclassified Bacteria	2|Bacteria	CH	Oxidoreductase NAD-binding domain	hdrF	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
SX2_k127_3053179_2	1499967.BAYZ01000171_gene5571	3.532e-89	302.0	COG1143@1|root,COG1143@2|Bacteria,2NQ09@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	asrA	-	-	ko:K16950	ko00920,ko01120,map00920,map01120	-	R00858,R10146	RC00065	ko00000,ko00001	-	-	-	Fer4_22
SX2_k127_3055854_1	744872.Spica_1284	2.965e-33	150.0	COG2348@1|root,COG2348@2|Bacteria,2J58H@203691|Spirochaetes	203691|Spirochaetes	V	Methicillin resistance protein	femA	-	-	-	-	-	-	-	-	-	-	-	FemAB
SX2_k127_3055854_0	1123274.KB899412_gene1496	4.592e-309	964.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,2J699@203691|Spirochaetes	203691|Spirochaetes	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
SX2_k127_3066278_4	1192034.CAP_8755	7.656e-32	133.0	COG0782@1|root,COG0782@2|Bacteria,1RAP0@1224|Proteobacteria,42UCT@68525|delta/epsilon subdivisions,2WPAW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus	greB	-	-	ko:K04760	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
SX2_k127_3066278_2	1304885.AUEY01000005_gene892	6.551e-84	296.0	COG0598@1|root,COG0598@2|Bacteria,1RGGI@1224|Proteobacteria,42UX4@68525|delta/epsilon subdivisions,2WQYH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM Mg2 transporter protein CorA family protein	-	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
SX2_k127_3066278_0	926569.ANT_22700	2.269e-230	727.0	COG1132@1|root,COG1132@2|Bacteria,2G7KA@200795|Chloroflexi	200795|Chloroflexi	P	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SX2_k127_3066278_1	926550.CLDAP_24870	1.263e-217	690.0	COG1132@1|root,COG1132@2|Bacteria,2G7KM@200795|Chloroflexi	200795|Chloroflexi	P	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SX2_k127_3066278_5	1131462.DCF50_p1169	4.693e-27	126.0	COG2768@1|root,COG2768@2|Bacteria,1UK08@1239|Firmicutes,25FG6@186801|Clostridia,267F2@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
SX2_k127_3066278_3	871963.Desdi_0780	3.132e-78	274.0	COG1456@1|root,COG1456@2|Bacteria,1TPYJ@1239|Firmicutes,2588C@186801|Clostridia,2601E@186807|Peptococcaceae	186801|Clostridia	C	CO dehydrogenase acetyl-CoA synthase delta subunit	-	-	2.1.1.245	ko:K00197	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD
SX2_k127_306715_2	5786.XP_003285766.1	1.988e-26	125.0	KOG4157@1|root,KOG4157@2759|Eukaryota,3XEI4@554915|Amoebozoa	554915|Amoebozoa	GO	WSC domain	-	-	-	-	-	-	-	-	-	-	-	-	CAP,WSC
SX2_k127_306715_4	767817.Desgi_0295	1.534e-14	87.0	COG2041@1|root,COG5492@1|root,COG2041@2|Bacteria,COG5492@2|Bacteria,1VGTP@1239|Firmicutes,25F88@186801|Clostridia,267CS@186807|Peptococcaceae	186801|Clostridia	N	PFAM S-layer domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SLH
SX2_k127_306715_3	1121344.JHZO01000003_gene886	2.443e-17	96.0	COG3291@1|root,COG4733@1|root,COG5279@1|root,COG3291@2|Bacteria,COG4733@2|Bacteria,COG5279@2|Bacteria	2|Bacteria	D	protein involved in cytokinesis, contains TGc (transglutaminase protease-like) domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Flg_new,SLH,fn3
SX2_k127_306715_5	565033.GACE_1435	4.219e-05	56.0	COG1305@1|root,arCOG02165@2157|Archaea	2157|Archaea	E	PFAM Transglutaminase-like	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
SX2_k127_306715_0	177437.HRM2_26180	1.15e-161	553.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,42NXT@68525|delta/epsilon subdivisions,2WIZ3@28221|Deltaproteobacteria,2MKIU@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,Pkinase,TPR_12
SX2_k127_3073075_0	573413.Spirs_2358	1.314e-118	429.0	COG0389@1|root,COG0389@2|Bacteria,2J5NZ@203691|Spirochaetes	203691|Spirochaetes	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_3077331_3	1499968.TCA2_2971	1.25e-105	356.0	COG1473@1|root,COG1473@2|Bacteria,1TQ7B@1239|Firmicutes,4HAIK@91061|Bacilli,26QTC@186822|Paenibacillaceae	91061|Bacilli	S	Peptidase dimerisation domain	-	-	-	ko:K12941,ko:K21613	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
SX2_k127_3077331_0	1499967.BAYZ01000146_gene6175	7.435e-190	621.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
SX2_k127_3077331_2	1499967.BAYZ01000146_gene6176	8.558e-117	383.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	ko:K02025,ko:K15771	ko02010,map02010	M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
SX2_k127_3077331_1	338969.Rfer_0952	4.176e-117	398.0	COG0395@1|root,COG0395@2|Bacteria,1MXTE@1224|Proteobacteria,2VZ7H@28216|Betaproteobacteria,4AJNY@80864|Comamonadaceae	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX2_k127_3077331_4	744872.Spica_0201	1.698e-72	249.0	COG0353@1|root,COG0353@2|Bacteria,2J74I@203691|Spirochaetes	203691|Spirochaetes	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
SX2_k127_3077331_5	1307761.L21SP2_3498	1.89e-28	117.0	COG0718@1|root,COG0718@2|Bacteria,2J90U@203691|Spirochaetes	203691|Spirochaetes	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
SX2_k127_3085123_0	96561.Dole_0981	6.477e-61	234.0	COG0642@1|root,COG0784@1|root,COG2202@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2MMQH@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg,sCache_2
SX2_k127_3092368_1	1191523.MROS_0957	4.941e-108	364.0	COG0572@1|root,COG0572@2|Bacteria	2|Bacteria	F	uridine kinase	udk	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
SX2_k127_3092368_0	485915.Dret_1447	1.003e-125	427.0	COG0436@1|root,COG0436@2|Bacteria,1MX43@1224|Proteobacteria,42Q5H@68525|delta/epsilon subdivisions,2WKW4@28221|Deltaproteobacteria,2M80H@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Aminotransferase, class I	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
SX2_k127_3092368_3	665571.STHERM_c15930	2.324e-31	134.0	COG0558@1|root,COG0558@2|Bacteria,2J7BV@203691|Spirochaetes	203691|Spirochaetes	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
SX2_k127_3092368_2	1123274.KB899433_gene1355	9.544e-35	141.0	COG0558@1|root,COG0558@2|Bacteria,2J7NA@203691|Spirochaetes	203691|Spirochaetes	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
SX2_k127_3097855_1	886293.Sinac_2843	6.84e-119	404.0	COG1680@1|root,COG2173@1|root,COG1680@2|Bacteria,COG2173@2|Bacteria,2IWSU@203682|Planctomycetes	203682|Planctomycetes	MV	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,Peptidase_M15
SX2_k127_3097855_0	1123274.KB899411_gene3031	3.228e-172	550.0	COG0017@1|root,COG0017@2|Bacteria,2J73H@203691|Spirochaetes	203691|Spirochaetes	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	-	-	6.1.1.23	ko:K09759	ko00970,map00970	M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
SX2_k127_3097855_6	671065.MetMK1DRAFT_00017720	1.524e-14	84.0	COG2159@1|root,arCOG01931@2157|Archaea,2XSAX@28889|Crenarchaeota	28889|Crenarchaeota	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
SX2_k127_3097855_3	1121346.KB899864_gene297	4.959e-81	294.0	COG2972@1|root,COG2972@2|Bacteria,1UCQF@1239|Firmicutes,4HEAY@91061|Bacilli,26QNI@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,His_kinase
SX2_k127_3097855_4	1120972.AUMH01000020_gene2132	5.925e-58	224.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UZKW@1239|Firmicutes,4HF1S@91061|Bacilli	91061|Bacilli	T	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
SX2_k127_3097855_2	717605.Theco_1256	2.883e-82	289.0	COG1653@1|root,COG1653@2|Bacteria,1TQJV@1239|Firmicutes,4IQAH@91061|Bacilli,2769S@186822|Paenibacillaceae	91061|Bacilli	G	ABC-type sugar transport system, periplasmic component	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
SX2_k127_3097855_5	1034769.KB910518_gene2512	2.417e-31	134.0	COG1175@1|root,COG1175@2|Bacteria,1TPTZ@1239|Firmicutes,4HB63@91061|Bacilli,26S91@186822|Paenibacillaceae	91061|Bacilli	G	ABC transporter permease	yesP	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX2_k127_3106850_0	926550.CLDAP_12260	2.058e-176	568.0	COG1874@1|root,COG1874@2|Bacteria,2G604@200795|Chloroflexi	200795|Chloroflexi	G	PFAM Glycoside hydrolase family 42 domain protein	-	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_42,Glyco_hydro_42C,Glyco_hydro_42M
SX2_k127_3106850_1	61647.LG71_13775	5.209e-37	146.0	COG2068@1|root,COG2068@2|Bacteria,1QE5N@1224|Proteobacteria,1S3GJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Mo(VI)-molybdopterin cytosine dinucleotide biosynthetic process	ygfJ	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019538,GO:0019637,GO:0019720,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061602,GO:0070567,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902759,GO:1902760	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_3649,iB21_1397.B21_02672,iECABU_c1320.ECABU_c31580,iECBD_1354.ECBD_0860,iECB_1328.ECB_02710,iECD_1391.ECD_02710,iEcHS_1320.EcHS_A3037	NTP_transf_3
SX2_k127_3106850_2	649743.HMPREF0972_01776	1.816e-24	104.0	COG2314@1|root,COG2314@2|Bacteria,2GU27@201174|Actinobacteria	201174|Actinobacteria	M	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2510,TM2
SX2_k127_3158874_2	1538295.JY96_07725	0.000138	54.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VI5V@28216|Betaproteobacteria,1KK2E@119065|unclassified Burkholderiales	28216|Betaproteobacteria	MU	Outer membrane efflux protein	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
SX2_k127_3158874_1	306281.AJLK01000040_gene599	2.749e-23	115.0	COG0845@1|root,COG0845@2|Bacteria,1G01U@1117|Cyanobacteria,1JH2G@1189|Stigonemataceae	1117|Cyanobacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
SX2_k127_3158874_0	264462.Bd0709	1.982e-150	514.0	COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,4308T@68525|delta/epsilon subdivisions,2MTI3@213481|Bdellovibrionales,2X727@28221|Deltaproteobacteria	213481|Bdellovibrionales	V	membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K02003,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
SX2_k127_3211476_2	945713.IALB_0533	4.498e-21	98.0	COG0745@1|root,COG0745@2|Bacteria	945713.IALB_0533|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_3211476_1	1191523.MROS_2485	1.988e-50	194.0	COG2204@1|root,COG5002@1|root,COG2204@2|Bacteria,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	ko:K03413,ko:K21993	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02000,ko02022,ko02035	1.A.16.2	-	-	Form_Nir_trans,GAF_2,GGDEF,HATPase_c,HTH_8,HisKA,PAS,PAS_4,Response_reg
SX2_k127_3211476_0	1123371.ATXH01000010_gene759	7.85e-80	274.0	COG0082@1|root,COG0082@2|Bacteria,2GGRE@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
SX2_k127_3211703_1	1009370.ALO_10029	2.268e-54	204.0	COG1706@1|root,COG1706@2|Bacteria,1U2PI@1239|Firmicutes,4H258@909932|Negativicutes	909932|Negativicutes	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgI	-	-	ko:K02394	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgI
SX2_k127_3211703_0	573413.Spirs_1790	1.01e-133	432.0	COG4786@1|root,COG4786@2|Bacteria,2J57D@203691|Spirochaetes	203691|Spirochaetes	N	flagellar basal-body rod protein FlgG	flgG	-	-	ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
SX2_k127_3211703_2	665571.STHERM_c07290	1.688e-19	88.0	COG4786@1|root,COG4786@2|Bacteria,2J5EJ@203691|Spirochaetes	203691|Spirochaetes	N	flagellar basal-body rod protein	flhO	-	-	ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
SX2_k127_3212444_4	545696.HOLDEFILI_00838	1.307e-27	114.0	COG0176@1|root,COG0176@2|Bacteria,1U9RA@1239|Firmicutes	1239|Firmicutes	H	Transaldolase	-	-	-	-	-	-	-	-	-	-	-	-	TAL_FSA
SX2_k127_3212444_1	1122214.AQWH01000009_gene2017	2.362e-77	273.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2TS02@28211|Alphaproteobacteria,2PKQP@255475|Aurantimonadaceae	28211|Alphaproteobacteria	C	Aldo/keto reductase family	mocA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0017144,GO:0034641,GO:0042723,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:1901360,GO:1901564	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SX2_k127_3212444_2	457570.Nther_2213	6.241e-63	242.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia	186801|Clostridia	G	Transketolase	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
SX2_k127_3212444_0	1121430.JMLG01000004_gene963	3.116e-99	332.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,2607I@186807|Peptococcaceae	186801|Clostridia	G	PFAM Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
SX2_k127_3212444_3	1385514.N782_15215	1.981e-59	227.0	COG1082@1|root,COG1082@2|Bacteria,1UITG@1239|Firmicutes,4HFIC@91061|Bacilli	91061|Bacilli	G	Xylose isomerase-like TIM barrel	-	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
SX2_k127_3212444_5	1202768.JROF01000005_gene2366	2.224e-05	55.0	COG1082@1|root,arCOG01895@2157|Archaea,2XW14@28890|Euryarchaeota,23U90@183963|Halobacteria	183963|Halobacteria	G	COG1082 Sugar phosphate isomerases epimerases	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SX2_k127_3212576_0	1173028.ANKO01000052_gene1629	7.257e-263	827.0	COG2256@1|root,COG2256@2|Bacteria,1G36R@1117|Cyanobacteria,1H9UW@1150|Oscillatoriales	1117|Cyanobacteria	L	ATPase family associated with various cellular activities (AAA)	mgs1	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
SX2_k127_3212576_3	545694.TREPR_0178	3.198e-100	337.0	COG0714@1|root,COG0714@2|Bacteria,2J5SG@203691|Spirochaetes	203691|Spirochaetes	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
SX2_k127_3212576_9	545695.TREAZ_2078	7.258e-19	99.0	29XQJ@1|root,30JG9@2|Bacteria,2J89K@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
SX2_k127_3212576_4	744872.Spica_2854	1.752e-81	306.0	COG0457@1|root,COG1305@1|root,COG0457@2|Bacteria,COG1305@2|Bacteria,2J681@203691|Spirochaetes	203691|Spirochaetes	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_7,TPR_8,Transglut_core
SX2_k127_3212576_5	545695.TREAZ_2068	3.007e-73	279.0	COG1305@1|root,COG1305@2|Bacteria,2J681@203691|Spirochaetes	203691|Spirochaetes	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_7,TPR_8,Transglut_core
SX2_k127_3212576_1	1304888.ATWF01000001_gene1470	1.179e-140	458.0	COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,2GFDI@200930|Deferribacteres	2|Bacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3369,GAF,GAF_2,HD,PAS_3,PAS_9,Response_reg
SX2_k127_3212576_6	1151117.AJLF01000001_gene1302	1.479e-60	223.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTX2@28890|Euryarchaeota,242XP@183968|Thermococci	183968|Thermococci	O	AIR synthase related protein, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AIRS,AIRS_C
SX2_k127_3212576_8	744872.Spica_1336	8.051e-38	155.0	2AMQG@1|root,31CKP@2|Bacteria,2J7X3@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_3212576_2	545694.TREPR_1182	3.212e-110	376.0	COG0514@1|root,COG0514@2|Bacteria,2J5BY@203691|Spirochaetes	203691|Spirochaetes	L	ATP-dependent DNA helicase RecQ	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecQ_Zn_bind
SX2_k127_3212576_7	555079.Toce_0241	2.756e-46	177.0	COG1905@1|root,COG1905@2|Bacteria,1V737@1239|Firmicutes,24I29@186801|Clostridia,42ICW@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit	nuoE	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
SX2_k127_3222403_7	1236976.JCM16418_1704	6.211e-06	52.0	COG1653@1|root,COG1653@2|Bacteria,1UYSZ@1239|Firmicutes,4HEMH@91061|Bacilli,26S1G@186822|Paenibacillaceae	91061|Bacilli	G	Extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1
SX2_k127_3222403_4	1120972.AUMH01000021_gene2281	1.417e-50	194.0	COG1609@1|root,COG1609@2|Bacteria,1TP9Q@1239|Firmicutes,4HARD@91061|Bacilli	91061|Bacilli	K	Transcriptional	araR	-	-	ko:K02103	-	-	-	-	ko00000,ko03000	-	-	-	GntR,Peripla_BP_3
SX2_k127_3222403_2	1227352.C173_05381	1.488e-82	288.0	COG1680@1|root,COG1680@2|Bacteria,1TR9E@1239|Firmicutes,4HER8@91061|Bacilli,26S99@186822|Paenibacillaceae	91061|Bacilli	V	Beta-lactamase class C and other penicillin binding	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SX2_k127_3222403_1	562970.Btus_1096	5.259e-85	300.0	COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,4HBJ6@91061|Bacilli,278QW@186823|Alicyclobacillaceae	91061|Bacilli	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	GO:0002097,GO:0002098,GO:0002143,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
SX2_k127_3222403_6	573413.Spirs_2549	1.331e-06	59.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Autoind_bind,GerE
SX2_k127_3222403_3	316067.Geob_2051	8.885e-68	253.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,42TQ5@68525|delta/epsilon subdivisions,2WQ0T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SX2_k127_3222403_0	720554.Clocl_1416	9.342e-168	534.0	COG0136@1|root,COG0136@2|Bacteria,1TPC6@1239|Firmicutes,248ZR@186801|Clostridia,3WGVU@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the aspartate-semialdehyde dehydrogenase family	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
SX2_k127_3222403_5	111781.Lepto7376_3756	1.252e-06	63.0	COG1572@1|root,COG3209@1|root,COG3210@1|root,COG1572@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	CARDB,RHS_repeat
SX2_k127_3224901_0	945713.IALB_0531	3.736e-210	667.0	COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria	2|Bacteria	C	iron-sulfur cluster assembly	-	-	1.12.1.3,1.6.5.3	ko:K00336,ko:K18332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_20,Fer4_6,Fer4_9,NADH-G_4Fe-4S_3,Pyr_redox_2
SX2_k127_3224901_1	945713.IALB_0530	3.094e-120	391.0	COG1894@1|root,COG3411@1|root,COG1894@2|Bacteria,COG3411@2|Bacteria	2|Bacteria	C	Ferredoxin	hoxF	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K05587,ko:K17992,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
SX2_k127_3237858_1	573413.Spirs_2346	8.993e-38	165.0	COG0457@1|root,COG1474@1|root,COG0457@2|Bacteria,COG1474@2|Bacteria,2J6N3@203691|Spirochaetes	203691|Spirochaetes	LO	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_3237858_0	665571.STHERM_c17580	1.743e-56	205.0	COG0778@1|root,COG0778@2|Bacteria,2J8VG@203691|Spirochaetes	203691|Spirochaetes	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
SX2_k127_3245375_1	573413.Spirs_4235	2.751e-36	147.0	2BWXM@1|root,318GB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_3245375_0	1123274.KB899426_gene2816	7.795e-139	452.0	COG0165@1|root,COG0165@2|Bacteria,2J5FG@203691|Spirochaetes	203691|Spirochaetes	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
SX2_k127_3256876_0	665571.STHERM_c02340	2.554e-111	366.0	COG0209@1|root,COG0209@2|Bacteria,2J5M3@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC,Ribonuc_red_lgN
SX2_k127_3256876_2	794903.OPIT5_20400	2.91e-26	125.0	COG1541@1|root,COG1541@2|Bacteria,46XXX@74201|Verrucomicrobia,3K79B@414999|Opitutae	414999|Opitutae	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	-
SX2_k127_3256876_3	1041522.MCOL_V206220	6.189e-20	99.0	COG3340@1|root,COG3340@2|Bacteria,2IC7Y@201174|Actinobacteria,234WT@1762|Mycobacteriaceae	201174|Actinobacteria	E	Peptidase family S51	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S51
SX2_k127_3256876_1	1307761.L21SP2_2597	1.588e-28	130.0	COG0204@1|root,COG0204@2|Bacteria,2JAJG@203691|Spirochaetes	203691|Spirochaetes	I	PFAM Phospholipid glycerol acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
SX2_k127_3257561_6	177437.HRM2_30890	1.903e-24	107.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIA4@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2
SX2_k127_3257561_9	644282.Deba_2131	6.202e-21	100.0	COG1908@1|root,COG1908@2|Bacteria,1RI0K@1224|Proteobacteria,42SSK@68525|delta/epsilon subdivisions,2WPF9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	FlpD
SX2_k127_3257561_5	264732.Moth_0438	5.622e-33	137.0	COG0509@1|root,COG0509@2|Bacteria,1V9VC@1239|Firmicutes,24QN1@186801|Clostridia,42IJ8@68295|Thermoanaerobacterales	186801|Clostridia	E	Glycine cleavage H-protein	-	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
SX2_k127_3257561_2	644282.Deba_2986	8.504e-103	346.0	COG0095@1|root,COG0095@2|Bacteria,1RDZE@1224|Proteobacteria	1224|Proteobacteria	H	PFAM biotin lipoate A B protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
SX2_k127_3257561_0	459349.CLOAM1211	3.327e-195	617.0	COG0205@1|root,COG0205@2|Bacteria,2NP3J@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K00850,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
SX2_k127_3257561_4	573370.DMR_40960	3.035e-43	175.0	COG1321@1|root,COG1321@2|Bacteria,1N3ZM@1224|Proteobacteria,42TUU@68525|delta/epsilon subdivisions,2WQ8Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KP	PFAM iron dependent repressor	ideR	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,FeoA
SX2_k127_3257561_1	573370.DMR_40970	6.22e-142	477.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42PVA@68525|delta/epsilon subdivisions,2WJ10@28221|Deltaproteobacteria,2MF67@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Nucleoside recognition	feoB-1	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
SX2_k127_3257561_8	903818.KI912268_gene2154	2.633e-23	106.0	COG0735@1|root,COG0735@2|Bacteria,3Y5IN@57723|Acidobacteria	57723|Acidobacteria	P	Ferric uptake regulator family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
SX2_k127_3257561_3	1007103.AFHW01000139_gene1443	3.3e-87	321.0	COG2114@1|root,COG5000@1|root,COG2114@2|Bacteria,COG5000@2|Bacteria,1V1JU@1239|Firmicutes,4HFW5@91061|Bacilli,26UQX@186822|Paenibacillaceae	91061|Bacilli	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
SX2_k127_3257561_7	1122947.FR7_0022	1.38e-23	107.0	COG1592@1|root,COG1592@2|Bacteria,1VCQR@1239|Firmicutes,4H5RG@909932|Negativicutes	909932|Negativicutes	C	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_3257561_10	404380.Gbem_1029	2.845e-15	83.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria	1224|Proteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Dak2,DegV,Radical_SAM
SX2_k127_3257561_12	2903.EOD21519	0.0007365	43.0	COG1231@1|root,KOG0029@2759|Eukaryota	2759|Eukaryota	E	oxidoreductase activity	PDS	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009507,GO:0009526,GO:0009534,GO:0009536,GO:0009579,GO:0009941,GO:0009987,GO:0016108,GO:0016109,GO:0016114,GO:0016116,GO:0016117,GO:0016166,GO:0016491,GO:0016627,GO:0031967,GO:0031975,GO:0031976,GO:0031984,GO:0042440,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046148,GO:0055114,GO:0071704,GO:1901576	1.3.5.5	ko:K02293	ko00906,ko01100,ko01110,map00906,map01100,map01110	M00097	R04786,R04787,R07510,R09652,R09653,R09654	RC01214,RC01958,RC03092,RC03093	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
SX2_k127_3257561_11	234267.Acid_6164	3.081e-05	55.0	COG0823@1|root,COG2374@1|root,COG3170@1|root,COG3291@1|root,COG3391@1|root,COG3867@1|root,COG4257@1|root,COG4625@1|root,COG0823@2|Bacteria,COG2374@2|Bacteria,COG3170@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,COG3867@2|Bacteria,COG4257@2|Bacteria,COG4625@2|Bacteria,3Y354@57723|Acidobacteria	2|Bacteria	M	PKD domain containing protein	-	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	3.2.1.4	ko:K01179,ko:K07004,ko:K13277,ko:K20276,ko:K21449	ko00500,ko01100,ko02024,map00500,map01100,map02024	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000,ko01002,ko02000,ko03110	1.B.40.2	GH5,GH9	-	Big_3_2,Exo_endo_phos,He_PIG,LTD
SX2_k127_3260202_3	545695.TREAZ_3416	2.691e-56	201.0	COG0589@1|root,COG0589@2|Bacteria,2J7EV@203691|Spirochaetes	203691|Spirochaetes	T	universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
SX2_k127_3260202_2	545694.TREPR_1215	2.408e-65	229.0	COG1394@1|root,COG1394@2|Bacteria,2J5V1@203691|Spirochaetes	203691|Spirochaetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
SX2_k127_3260202_1	1125699.HMPREF9194_00493	1.38e-211	670.0	COG1156@1|root,COG1156@2|Bacteria,2J5SP@203691|Spirochaetes	203691|Spirochaetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
SX2_k127_3260202_0	1125699.HMPREF9194_00494	1.105e-253	805.0	COG1155@1|root,COG1155@2|Bacteria,2J5EF@203691|Spirochaetes	203691|Spirochaetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
SX2_k127_3260202_4	1321815.HMPREF9193_01399	2.125e-11	72.0	2C65T@1|root,301BP@2|Bacteria,2J7YG@203691|Spirochaetes	203691|Spirochaetes	S	ATPase subunit E	-	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	-
SX2_k127_3263605_1	573413.Spirs_2536	4.503e-192	616.0	COG0480@1|root,COG0480@2|Bacteria,2J5YJ@203691|Spirochaetes	203691|Spirochaetes	J	translation elongation factor	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
SX2_k127_3263605_0	744872.Spica_0853	2.535e-282	887.0	COG0480@1|root,COG0480@2|Bacteria,2J5D3@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
SX2_k127_3263605_2	749414.SBI_09133	4.545e-05	51.0	COG2310@1|root,COG2340@1|root,COG2310@2|Bacteria,COG2340@2|Bacteria,2GNN0@201174|Actinobacteria	201174|Actinobacteria	T	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP,TerD
SX2_k127_3272910_2	889378.Spiaf_0555	2.495e-71	250.0	COG0088@1|root,COG0088@2|Bacteria,2J5NS@203691|Spirochaetes	203691|Spirochaetes	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
SX2_k127_3272910_3	1123274.KB899411_gene3113	7.806e-71	252.0	COG0087@1|root,COG0087@2|Bacteria,2J633@203691|Spirochaetes	203691|Spirochaetes	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
SX2_k127_3272910_4	1480694.DC28_14360	1.8e-44	181.0	COG0051@1|root,COG0051@2|Bacteria,2J7XK@203691|Spirochaetes	203691|Spirochaetes	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
SX2_k127_3272910_1	744872.Spica_0383	5.881e-205	647.0	COG0050@1|root,COG0050@2|Bacteria,2J5PY@203691|Spirochaetes	203691|Spirochaetes	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
SX2_k127_3272910_0	760142.Hipma_1380	6.05e-222	700.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2WIM7@28221|Deltaproteobacteria,2M6MN@213113|Desulfurellales	28221|Deltaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
SX2_k127_329185_17	1168034.FH5T_01550	9.418e-06	58.0	COG1520@1|root,COG1520@2|Bacteria,4P1VG@976|Bacteroidetes,2FW8D@200643|Bacteroidia	976|Bacteroidetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
SX2_k127_329185_3	1168034.FH5T_01555	1.416e-107	363.0	COG0348@1|root,COG0348@2|Bacteria,4NPVD@976|Bacteroidetes,2FTEY@200643|Bacteroidia	976|Bacteroidetes	C	FMN-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_5
SX2_k127_329185_10	1168034.FH5T_01560	1.362e-58	212.0	2DVMZ@1|root,33WFQ@2|Bacteria,4P3VR@976|Bacteroidetes,2FXVM@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	-
SX2_k127_329185_12	595460.RRSWK_06184	1.217e-40	167.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	NHL
SX2_k127_329185_2	1168034.FH5T_01575	4.961e-137	451.0	COG1520@1|root,COG1520@2|Bacteria,4P15Y@976|Bacteroidetes,2FWBU@200643|Bacteroidia	976|Bacteroidetes	S	PQQ-like domain	-	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2
SX2_k127_329185_13	1382358.JHVN01000003_gene2767	3.813e-30	134.0	COG1940@1|root,COG1940@2|Bacteria,1TQCE@1239|Firmicutes,4HDE3@91061|Bacilli,21VCB@150247|Anoxybacillus	91061|Bacilli	GK	ROK family	xylR	-	-	-	-	-	-	-	-	-	-	-	HTH_24,MarR_2,ROK
SX2_k127_329185_14	1122919.KB905569_gene2911	9.192e-25	116.0	COG0673@1|root,COG0673@2|Bacteria,1TQ72@1239|Firmicutes,4HAGN@91061|Bacilli,26ST6@186822|Paenibacillaceae	91061|Bacilli	K	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX2_k127_329185_9	985665.HPL003_21875	6.003e-69	254.0	COG1653@1|root,COG1653@2|Bacteria,1V02Z@1239|Firmicutes,4IR6G@91061|Bacilli,26SPQ@186822|Paenibacillaceae	91061|Bacilli	G	transport	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_1,SBP_bac_8
SX2_k127_329185_11	743719.PaelaDRAFT_2939	5.11e-52	205.0	COG0395@1|root,COG0395@2|Bacteria,1TS0D@1239|Firmicutes,4HA5Y@91061|Bacilli,26R41@186822|Paenibacillaceae	91061|Bacilli	G	ABC transporter permease	-	-	-	ko:K17320	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
SX2_k127_329185_5	189426.PODO_14825	3.433e-96	325.0	COG4209@1|root,COG4209@2|Bacteria,1TP33@1239|Firmicutes,4HD71@91061|Bacilli,26QGE@186822|Paenibacillaceae	91061|Bacilli	G	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
SX2_k127_329185_1	1304880.JAGB01000002_gene2262	3.802e-149	484.0	COG0673@1|root,COG0673@2|Bacteria,1U4A4@1239|Firmicutes,249UF@186801|Clostridia	186801|Clostridia	E	PFAM oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
SX2_k127_329185_4	1304880.JAGB01000002_gene2263	2.243e-100	337.0	COG3828@1|root,COG3828@2|Bacteria,1TT0R@1239|Firmicutes,24BID@186801|Clostridia	186801|Clostridia	S	Trehalose utilisation	-	-	-	ko:K09992	-	-	-	-	ko00000	-	-	-	ThuA
SX2_k127_329185_8	519989.ECTPHS_10481	3.245e-69	267.0	COG1538@1|root,COG1538@2|Bacteria,1R705@1224|Proteobacteria,1S0X1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	MU	PFAM Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
SX2_k127_329185_0	690850.Desaf_3621	2.04e-321	1020.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2M7S1@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
SX2_k127_329185_7	1499967.BAYZ01000151_gene1667	3.654e-71	256.0	COG0845@1|root,COG0845@2|Bacteria,2NP97@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005,ko:K15727	-	-	-	-	ko00000,ko02000	8.A.1.2.1	-	-	HlyD_D23
SX2_k127_329185_16	471855.Shel_25910	3.029e-08	60.0	COG1476@1|root,COG2002@1|root,COG1476@2|Bacteria,COG2002@2|Bacteria,2H8HI@201174|Actinobacteria,4CW84@84998|Coriobacteriia	84998|Coriobacteriia	K	AbrB family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
SX2_k127_329185_6	1480694.DC28_06800	8.594e-95	339.0	COG1136@1|root,COG1136@2|Bacteria,2J5PI@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX2_k127_329185_15	1480694.DC28_06805	2.993e-12	67.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,2J5MA@203691|Spirochaetes	203691|Spirochaetes	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
SX2_k127_3294066_1	1125863.JAFN01000001_gene3060	5.732e-80	274.0	COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42Q13@68525|delta/epsilon subdivisions,2WJHD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Pterin binding enzyme	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
SX2_k127_3294066_0	1499967.BAYZ01000171_gene5559	2.175e-119	399.0	COG0190@1|root,COG0190@2|Bacteria,2NNY1@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
SX2_k127_3302185_0	237368.SCABRO_01048	1.5e-323	1025.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,2J293@203682|Planctomycetes	203682|Planctomycetes	I	CoA enzyme activase uncharacterised domain (DUF2229)	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
SX2_k127_3302185_2	573413.Spirs_2617	3.533e-48	190.0	COG3359@1|root,COG3359@2|Bacteria,2J801@203691|Spirochaetes	203691|Spirochaetes	L	RNase_H superfamily	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
SX2_k127_3302185_1	1307761.L21SP2_1222	1.134e-277	869.0	COG1205@1|root,COG1205@2|Bacteria,2J5DK@203691|Spirochaetes	203691|Spirochaetes	L	DEAD DEAH box helicase	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
SX2_k127_331444_1	1480694.DC28_14400	7.057e-91	302.0	COG0081@1|root,COG0081@2|Bacteria,2J5HN@203691|Spirochaetes	203691|Spirochaetes	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
SX2_k127_331444_3	573413.Spirs_0947	1.321e-45	170.0	COG0244@1|root,COG0244@2|Bacteria,2J74F@203691|Spirochaetes	203691|Spirochaetes	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
SX2_k127_331444_2	744872.Spica_0378	7.384e-49	177.0	COG0222@1|root,COG0222@2|Bacteria,2J7NX@203691|Spirochaetes	203691|Spirochaetes	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
SX2_k127_331444_0	889378.Spiaf_0548	0.0	1169.0	COG0085@1|root,COG0085@2|Bacteria,2J5JV@203691|Spirochaetes	203691|Spirochaetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
SX2_k127_3354664_0	395961.Cyan7425_4406	5.676e-82	291.0	COG0204@1|root,COG0204@2|Bacteria,1G0U3@1117|Cyanobacteria,3KFP1@43988|Cyanothece	1117|Cyanobacteria	I	phospholipid glycerol acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
SX2_k127_3354664_1	926550.CLDAP_35600	2.52e-34	139.0	COG1653@1|root,COG1653@2|Bacteria,2G8XC@200795|Chloroflexi	200795|Chloroflexi	G	COGs COG1653 ABC-type sugar transport system periplasmic component	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
SX2_k127_3356323_3	1123274.KB899421_gene1778	1.418e-49	189.0	COG1361@1|root,COG1361@2|Bacteria	2|Bacteria	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Cohesin,DUF11,SLH
SX2_k127_3356323_2	1123274.KB899421_gene1777	2.509e-50	192.0	COG1729@1|root,COG1729@2|Bacteria,2J5PP@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
SX2_k127_3356323_1	545695.TREAZ_0531	4.737e-73	252.0	COG0036@1|root,COG0036@2|Bacteria,2J7B7@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
SX2_k127_3356323_0	744872.Spica_1366	2.149e-79	287.0	COG0457@1|root,COG0457@2|Bacteria,2J7GS@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19,TPR_8
SX2_k127_3366368_2	604354.TSIB_1519	9.892e-37	141.0	COG1905@1|root,arCOG04890@2157|Archaea,2XYS3@28890|Euryarchaeota,243WU@183968|Thermococci	183968|Thermococci	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
SX2_k127_3366368_0	1151117.AJLF01000002_gene333	3.237e-249	786.0	COG1145@1|root,COG1894@1|root,arCOG01610@2157|Archaea,arCOG04537@2157|Archaea,2XUYN@28890|Euryarchaeota,243V2@183968|Thermococci	183968|Thermococci	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
SX2_k127_3366368_1	1089553.Tph_c08060	8.346e-111	367.0	COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,42EUY@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.17.1.10,1.17.1.9,1.97.1.9	ko:K00123,ko:K12527,ko:K15022	ko00450,ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00450,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519,R07229	RC02420,RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_20,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Pyr_redox_2,Pyr_redox_3
SX2_k127_3367613_3	744872.Spica_2619	2.435e-86	289.0	COG0765@1|root,COG0765@2|Bacteria,2J5BG@203691|Spirochaetes	203691|Spirochaetes	P	TIGRFAM amine acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine family	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
SX2_k127_3367613_2	1480694.DC28_09045	3.999e-106	349.0	COG1126@1|root,COG1126@2|Bacteria,2J5V5@203691|Spirochaetes	203691|Spirochaetes	E	ABC-type polar amino acid transport system ATPase component	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
SX2_k127_3367613_5	1123274.KB899430_gene1690	2.831e-23	101.0	COG0828@1|root,COG0828@2|Bacteria,2J8QT@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
SX2_k127_3367613_4	1321815.HMPREF9193_01606	3.431e-45	187.0	COG0739@1|root,COG0739@2|Bacteria,2J7J7@203691|Spirochaetes	203691|Spirochaetes	M	M23 M37 peptidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
SX2_k127_3367613_0	665571.STHERM_c06530	5.909e-176	576.0	COG0608@1|root,COG0608@2|Bacteria,2J5KW@203691|Spirochaetes	203691|Spirochaetes	L	single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
SX2_k127_3367613_1	665571.STHERM_c06520	5.325e-144	470.0	COG0213@1|root,COG0213@2|Bacteria,2J607@203691|Spirochaetes	203691|Spirochaetes	F	pyrimidine-nucleoside phosphorylase	pdp	-	2.4.2.2	ko:K00756	ko00240,ko01100,map00240,map01100	-	R01570,R01876,R02296,R02484	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
SX2_k127_3378489_2	889378.Spiaf_0089	5.009e-74	271.0	COG0047@1|root,COG0047@2|Bacteria,2J8JD@203691|Spirochaetes	203691|Spirochaetes	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	-	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
SX2_k127_3378489_0	1307761.L21SP2_0016	2.409e-295	935.0	COG0046@1|root,COG0046@2|Bacteria,2J66J@203691|Spirochaetes	203691|Spirochaetes	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
SX2_k127_3378489_4	509191.AEDB02000100_gene4093	1.97e-23	114.0	COG2208@1|root,COG2208@2|Bacteria,1TQY5@1239|Firmicutes,249WB@186801|Clostridia,3WNE8@541000|Ruminococcaceae	186801|Clostridia	KT	Membrane-associated sensor domain	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	MASE3,SpoIIE
SX2_k127_3378489_7	751945.Theos_0634	0.0007536	51.0	COG0664@1|root,COG0664@2|Bacteria,1WIWX@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	COGs COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
SX2_k127_3378489_3	716544.wcw_0275	1.853e-32	136.0	COG2120@1|root,COG2120@2|Bacteria,2JG3Z@204428|Chlamydiae	204428|Chlamydiae	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
SX2_k127_3378489_1	1304880.JAGB01000002_gene1654	6.681e-172	559.0	COG1979@1|root,COG1979@2|Bacteria,1TPS3@1239|Firmicutes,248DW@186801|Clostridia	186801|Clostridia	C	alcohol dehydrogenase	-	-	-	ko:K19955	-	-	-	-	ko00000,ko01000	-	-	-	Fe-ADH
SX2_k127_3378489_6	906968.Trebr_0826	2.676e-07	62.0	2BTSM@1|root,32P03@2|Bacteria,2J74P@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_3378489_5	1123274.KB899407_gene243	5.242e-19	89.0	COG0442@1|root,COG0442@2|Bacteria,2J5HF@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
SX2_k127_3387395_3	293826.Amet_3719	6.925e-130	422.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia,36DTX@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SX2_k127_3387395_5	1194165.CAJF01000005_gene2311	1.345e-105	358.0	COG5621@1|root,COG5621@2|Bacteria,2GNHM@201174|Actinobacteria	201174|Actinobacteria	S	secreted hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CrtC
SX2_k127_3387395_0	1128421.JAGA01000002_gene1476	8.35e-158	508.0	COG4806@1|root,COG4806@2|Bacteria	2|Bacteria	G	L-rhamnose isomerase activity	rhaA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0008270,GO:0008740,GO:0009056,GO:0009987,GO:0016043,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019299,GO:0019301,GO:0019318,GO:0019320,GO:0019321,GO:0019324,GO:0022607,GO:0030145,GO:0030246,GO:0032991,GO:0033296,GO:0036094,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0046872,GO:0046914,GO:0048029,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901575	2.7.1.5,5.3.1.14	ko:K00848,ko:K01813	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01902,R02437,R03014	RC00002,RC00017,RC00434	ko00000,ko00001,ko01000	-	-	iECIAI39_1322.ECIAI39_3092,iUMNK88_1353.UMNK88_4739	RhaA
SX2_k127_3387395_4	1195236.CTER_3527	7.139e-113	377.0	COG1453@1|root,COG1453@2|Bacteria,1TSTA@1239|Firmicutes,249IP@186801|Clostridia,3WIUA@541000|Ruminococcaceae	186801|Clostridia	S	aldo keto reductase family	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
SX2_k127_3387395_8	1123248.KB893320_gene3890	1.288e-31	142.0	COG3595@1|root,COG3595@2|Bacteria,4NSAQ@976|Bacteroidetes,1ITBV@117747|Sphingobacteriia	976|Bacteroidetes	S	Putative auto-transporter adhesin, head GIN domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2807
SX2_k127_3387395_6	1120950.KB892794_gene2342	1.021e-75	279.0	COG1680@1|root,COG1680@2|Bacteria,2GNNF@201174|Actinobacteria,4DQ3J@85009|Propionibacteriales	201174|Actinobacteria	V	Beta-lactamase	ampC2	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SX2_k127_3387395_9	1202768.JROF01000017_gene1270	4.156e-18	96.0	COG1506@1|root,arCOG05706@2157|Archaea,2Y819@28890|Euryarchaeota,2412E@183963|Halobacteria	183963|Halobacteria	E	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
SX2_k127_3387395_2	56107.Cylst_1884	1.525e-133	441.0	COG1819@1|root,COG1819@2|Bacteria,1G036@1117|Cyanobacteria,1HMT6@1161|Nostocales	1117|Cyanobacteria	CG	Glycosyltransferase family 28 N-terminal domain	-	-	2.4.1.173	ko:K05841	-	-	-	-	ko00000,ko01000,ko01003	-	GT1	-	Glyco_transf_28,UDPGT
SX2_k127_3387395_10	1382356.JQMP01000003_gene1648	1.032e-15	88.0	COG3568@1|root,COG3568@2|Bacteria,2G7ER@200795|Chloroflexi,27XU2@189775|Thermomicrobia	189775|Thermomicrobia	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
SX2_k127_3387395_1	1007103.AFHW01000016_gene5923	1.782e-146	485.0	COG0667@1|root,COG0667@2|Bacteria,1TRS0@1239|Firmicutes,4HAZ2@91061|Bacilli,26S6B@186822|Paenibacillaceae	91061|Bacilli	C	L-glyceraldehyde 3-phosphate reductase	yghZ	-	-	ko:K19265	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
SX2_k127_3387395_7	370438.PTH_0934	1.253e-38	151.0	COG1236@1|root,COG1236@2|Bacteria,1UPPD@1239|Firmicutes,25HKE@186801|Clostridia,263Z3@186807|Peptococcaceae	186801|Clostridia	L	Metallo-beta-lactamase superfamily	-	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	-
SX2_k127_3390851_7	1125700.HMPREF9195_00866	2.113e-33	142.0	COG2265@1|root,COG2265@2|Bacteria,2J5Y7@203691|Spirochaetes	203691|Spirochaetes	H	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	ygcA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
SX2_k127_3390851_5	573370.DMR_p1_00410	6.547e-60	214.0	COG0279@1|root,COG0279@2|Bacteria,1NVIE@1224|Proteobacteria,42QUT@68525|delta/epsilon subdivisions,2X5WE@28221|Deltaproteobacteria,2MGWI@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
SX2_k127_3390851_2	411902.CLOBOL_03987	1.704e-104	349.0	COG1940@1|root,COG1940@2|Bacteria,1TRGJ@1239|Firmicutes,248TJ@186801|Clostridia,21Z9D@1506553|Lachnoclostridium	186801|Clostridia	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
SX2_k127_3390851_6	697281.Mahau_0767	1.239e-51	202.0	COG0407@1|root,COG0407@2|Bacteria,1V4WM@1239|Firmicutes,24IZV@186801|Clostridia,42J2I@68295|Thermoanaerobacterales	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
SX2_k127_3390851_4	1122933.JNIY01000003_gene702	5.096e-73	259.0	COG0121@1|root,COG0121@2|Bacteria	2|Bacteria	S	cellular modified histidine biosynthetic process	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	PI-PLC-C1
SX2_k127_3390851_0	1499967.BAYZ01000009_gene5236	7.65e-134	437.0	COG0412@1|root,COG0412@2|Bacteria	2|Bacteria	Q	carboxymethylenebutenolidase activity	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_7,DLH,Peptidase_S9
SX2_k127_3390851_8	1121090.KB894694_gene2093	1.247e-13	76.0	COG3118@1|root,COG3118@2|Bacteria,1VEPC@1239|Firmicutes,4HNXE@91061|Bacilli,1ZI6R@1386|Bacillus	91061|Bacilli	O	Protein of unknown function (DUF2847)	ytxJ	-	-	-	-	-	-	-	-	-	-	-	DUF2847
SX2_k127_3390851_3	926569.ANT_02890	3.937e-100	341.0	COG1738@1|root,COG1738@2|Bacteria,2G6BZ@200795|Chloroflexi	200795|Chloroflexi	S	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage	-	-	-	ko:K09125	-	-	-	-	ko00000	-	-	-	Vut_1
SX2_k127_3390851_1	1047013.AQSP01000134_gene1371	2.179e-115	383.0	COG0531@1|root,COG0589@1|root,COG0531@2|Bacteria,COG0589@2|Bacteria,2NS54@2323|unclassified Bacteria	2|Bacteria	E	Amino acid permease	ybaT	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009268,GO:0009628,GO:0010035,GO:0010038,GO:0016020,GO:0042221,GO:0044464,GO:0046688,GO:0050896,GO:0071944,GO:0097501,GO:1990169	-	ko:K07076,ko:K11932,ko:K16263	-	-	-	-	ko00000,ko02000	2.A.3.13	-	-	AA_permease_2,Usp
SX2_k127_3405719_4	744872.Spica_0548	3.276e-37	148.0	COG0454@1|root,COG0456@2|Bacteria,2J74W@203691|Spirochaetes	203691|Spirochaetes	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,UPF0158
SX2_k127_3405719_0	889378.Spiaf_0670	3.234e-221	696.0	COG0148@1|root,COG0148@2|Bacteria,2J59Y@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
SX2_k127_3405719_2	1379270.AUXF01000001_gene1910	2.974e-67	237.0	COG0179@1|root,COG0179@2|Bacteria,1ZTIG@142182|Gemmatimonadetes	2|Bacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
SX2_k127_3405719_1	525904.Tter_2468	1.066e-205	674.0	COG4354@1|root,COG4354@2|Bacteria,2NQ9B@2323|unclassified Bacteria	2|Bacteria	G	beta-glucosidase 2, glycosyl-hydrolase family 116 N-term	-	-	-	-	-	-	-	-	-	-	-	-	DUF608,Glyco_hydr_116N
SX2_k127_3405719_3	744872.Spica_2326	2.551e-63	225.0	COG0120@1|root,COG0120@2|Bacteria,2J575@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
SX2_k127_3405719_5	1123274.KB899408_gene3882	4.394e-14	84.0	COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,2J8E5@203691|Spirochaetes	203691|Spirochaetes	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
SX2_k127_3463689_3	289377.HL41_01260	8.599e-55	216.0	COG0065@1|root,COG0065@2|Bacteria,2GH30@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
SX2_k127_3463689_1	1121428.DESHY_150097___1	3.857e-185	601.0	COG0119@1|root,COG0119@2|Bacteria,1TP4Y@1239|Firmicutes,2485A@186801|Clostridia,260GB@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
SX2_k127_3463689_4	1121430.JMLG01000011_gene347	5.688e-50	183.0	COG0440@1|root,COG0440@2|Bacteria,1V2AJ@1239|Firmicutes,24HZM@186801|Clostridia,261FW@186807|Peptococcaceae	186801|Clostridia	E	TIGRFAM Acetolactate synthase, small subunit	ilvH	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
SX2_k127_3463689_0	588581.Cpap_1800	5.272e-229	724.0	COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,2480U@186801|Clostridia,3WGYC@541000|Ruminococcaceae	186801|Clostridia	H	Thiamine pyrophosphate enzyme, central domain	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
SX2_k127_3463689_2	744872.Spica_0016	7.696e-96	321.0	COG1639@1|root,COG1639@2|Bacteria,2J5NU@203691|Spirochaetes	203691|Spirochaetes	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
SX2_k127_355291_3	1125700.HMPREF9195_01810	5.489e-07	63.0	COG0340@1|root,COG0340@2|Bacteria,2J617@203691|Spirochaetes	203691|Spirochaetes	H	biotin acetyl-CoA-carboxylase ligase	-	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB
SX2_k127_355291_0	889378.Spiaf_0198	1.529e-164	535.0	COG0364@1|root,COG0364@2|Bacteria,2J6N0@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
SX2_k127_355291_1	889378.Spiaf_0197	4.974e-29	136.0	COG3429@1|root,COG3429@2|Bacteria,2JB35@203691|Spirochaetes	203691|Spirochaetes	G	Glucose-6-phosphate dehydrogenase subunit	-	-	-	-	-	-	-	-	-	-	-	-	OpcA_G6PD_assem
SX2_k127_355291_2	221360.RS9917_11990	2.606e-25	123.0	COG0363@1|root,COG0363@2|Bacteria,1G20H@1117|Cyanobacteria,1GZ3E@1129|Synechococcus	1117|Cyanobacteria	G	6-phosphogluconolactonase	pgl	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
SX2_k127_3602790_5	999547.KI421500_gene2477	1.351e-09	70.0	COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2TRVB@28211|Alphaproteobacteria,28151@191028|Leisingera	28211|Alphaproteobacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,Methyltransf_23,TPR_1,TPR_10,TPR_11,TPR_12,TPR_16,TPR_2,TPR_8
SX2_k127_3602790_3	744872.Spica_1979	1.188e-71	248.0	COG0563@1|root,COG0563@2|Bacteria,2J6MV@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
SX2_k127_3602790_0	1191523.MROS_1378	7.882e-183	585.0	COG0499@1|root,COG0499@2|Bacteria	2|Bacteria	H	adenosylhomocysteinase activity	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
SX2_k127_3602790_2	1195236.CTER_5007	3.949e-105	351.0	COG1995@1|root,COG1995@2|Bacteria,1TQGT@1239|Firmicutes,24A12@186801|Clostridia,3WIJ8@541000|Ruminococcaceae	186801|Clostridia	C	Belongs to the PdxA family	pdxA	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
SX2_k127_3602790_4	657322.FPR_17360	9.721e-63	243.0	COG3395@1|root,COG3395@2|Bacteria,1TPNP@1239|Firmicutes,25CF7@186801|Clostridia	186801|Clostridia	S	Putative sugar-binding N-terminal domain	-	-	2.7.1.219,2.7.1.220	ko:K22129	-	-	-	-	ko00000,ko01000	-	-	-	DUF1357_C,DUF1537
SX2_k127_3602790_1	1195236.CTER_5009	8.022e-125	412.0	COG2768@1|root,COG2768@2|Bacteria,1TPRV@1239|Firmicutes,247PJ@186801|Clostridia,3WNJU@541000|Ruminococcaceae	186801|Clostridia	C	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088,DUF362
SX2_k127_3604241_2	573413.Spirs_0929	8.225e-38	148.0	COG0542@1|root,COG0542@2|Bacteria,2J57C@203691|Spirochaetes	203691|Spirochaetes	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
SX2_k127_3604241_3	936573.HMPREF1147_2094	2.159e-20	97.0	COG0607@1|root,COG0607@2|Bacteria,1U0PW@1239|Firmicutes,4H5KG@909932|Negativicutes	909932|Negativicutes	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
SX2_k127_3604241_0	1047013.AQSP01000125_gene2629	1.428e-74	272.0	COG4365@1|root,COG4365@2|Bacteria,2NP8Q@2323|unclassified Bacteria	2|Bacteria	S	Bacillithiol biosynthesis BshC	bshC	-	-	ko:K22136	-	-	-	-	ko00000	-	-	-	BshC
SX2_k127_3604241_1	906968.Trebr_1506	8.196e-45	178.0	COG4372@1|root,COG4372@2|Bacteria,2J5RI@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Borrelia P83 100 protein	-	-	-	-	-	-	-	-	-	-	-	-	Borrelia_P83
SX2_k127_3611883_2	907348.TresaDRAFT_0165	0.0002294	44.0	COG0500@1|root,COG1861@1|root,COG0500@2|Bacteria,COG1861@2|Bacteria,2J58C@203691|Spirochaetes	203691|Spirochaetes	M	spore coat polysaccharide biosynthesis protein	spsF	-	-	ko:K07257	-	-	-	-	ko00000	-	-	-	CTP_transf_3,Methyltransf_23
SX2_k127_3611883_1	889378.Spiaf_1678	2.599e-58	218.0	COG1216@1|root,COG1216@2|Bacteria,2J6ET@203691|Spirochaetes	203691|Spirochaetes	S	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_3611883_0	665571.STHERM_c09600	3.398e-95	321.0	COG0535@1|root,COG0535@2|Bacteria,2J6HP@203691|Spirochaetes	203691|Spirochaetes	S	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
SX2_k127_3625590_1	935840.JAEQ01000030_gene852	2.105e-119	399.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TRGY@28211|Alphaproteobacteria,43P37@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
SX2_k127_3625590_0	1123237.Salmuc_00331	1.099e-201	639.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG4584 Transposase and inactivated derivatives	istA	-	-	-	-	-	-	-	-	-	-	-	rve
SX2_k127_3627325_3	158189.SpiBuddy_0934	3.474e-52	190.0	COG2509@1|root,COG2509@2|Bacteria,2J6ED@203691|Spirochaetes	203691|Spirochaetes	S	Oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	Pyr_redox_2
SX2_k127_3627325_2	344747.PM8797T_04495	1.837e-105	354.0	COG2017@1|root,COG2017@2|Bacteria,2IWRW@203682|Planctomycetes	203682|Planctomycetes	G	Converts alpha-aldose to the beta-anomer	-	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
SX2_k127_3627325_0	1499967.BAYZ01000032_gene1133	8.047e-199	630.0	COG0205@1|root,COG0205@2|Bacteria,2NP3J@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfkA	-	2.7.1.11,2.7.1.90	ko:K00850,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
SX2_k127_3627325_1	697281.Mahau_2769	4.658e-143	481.0	COG5598@1|root,COG5598@2|Bacteria,1TR30@1239|Firmicutes,2586Z@186801|Clostridia,42IEI@68295|Thermoanaerobacterales	186801|Clostridia	H	Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
SX2_k127_3627325_7	1449976.KALB_3554	3.937e-06	59.0	COG0558@1|root,COG0558@2|Bacteria,2GM3F@201174|Actinobacteria,4E1RM@85010|Pseudonocardiales	201174|Actinobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA2	GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
SX2_k127_3627325_5	314287.GB2207_05167	2.187e-09	66.0	COG0558@1|root,COG0558@2|Bacteria,1N35Q@1224|Proteobacteria,1T0Q8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
SX2_k127_3627325_4	1123274.KB899409_gene574	3.062e-45	171.0	COG1011@1|root,COG1011@2|Bacteria,2J7J2@203691|Spirochaetes	203691|Spirochaetes	E	TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED	-	-	3.1.3.10	ko:K07025,ko:K20866	ko00010,ko01120,map00010,map01120	-	R00947	RC00078	ko00000,ko00001,ko01000	-	-	-	HAD_2
SX2_k127_3627325_6	660470.Theba_0500	4.847e-09	57.0	COG0395@1|root,COG0395@2|Bacteria,2GCCU@200918|Thermotogae	200918|Thermotogae	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX2_k127_3679537_0	1123274.KB899414_gene3655	1.077e-190	605.0	COG0504@1|root,COG0504@2|Bacteria,2J5AB@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
SX2_k127_3679537_1	573061.Clocel_3102	6.42e-49	195.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SX2_k127_3684899_8	1120954.ATXE01000003_gene672	3.116e-26	110.0	COG0211@1|root,COG0211@2|Bacteria,2IQDI@201174|Actinobacteria,4DRNG@85009|Propionibacteriales	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
SX2_k127_3684899_1	744872.Spica_0785	2.847e-109	368.0	COG0536@1|root,COG0536@2|Bacteria,2J5QY@203691|Spirochaetes	203691|Spirochaetes	C	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1,Radical_SAM
SX2_k127_3684899_5	665571.STHERM_c10300	5.826e-47	183.0	COG1057@1|root,COG1057@2|Bacteria,2J65I@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like,HD
SX2_k127_3684899_2	1123274.KB899415_gene2423	9.815e-76	269.0	COG1316@1|root,COG1316@2|Bacteria,2J57I@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Cell envelope-related transcriptional attenuator domain	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
SX2_k127_3684899_10	1123274.KB899415_gene2424	3.345e-23	107.0	COG0799@1|root,COG0799@2|Bacteria,2J84Q@203691|Spirochaetes	203691|Spirochaetes	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
SX2_k127_3684899_11	573413.Spirs_1811	1.145e-12	74.0	COG1406@1|root,COG1406@2|Bacteria	2|Bacteria	N	Chemotaxis phosphatase CheX	-	-	-	ko:K03409	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheX
SX2_k127_3684899_7	243276.TPANIC_0371	4.928e-41	170.0	COG1947@1|root,COG1947@2|Bacteria,2J7N4@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
SX2_k127_3684899_9	1307761.L21SP2_1447	3.316e-26	122.0	COG2088@1|root,COG2088@2|Bacteria,2J7XR@203691|Spirochaetes	203691|Spirochaetes	D	Could be involved in septation	spoVG	-	-	ko:K06412	-	-	-	-	ko00000	-	-	-	SpoVG
SX2_k127_3684899_3	1480694.DC28_01175	2.702e-53	198.0	COG1825@1|root,COG1825@2|Bacteria,2J75H@203691|Spirochaetes	203691|Spirochaetes	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
SX2_k127_3684899_6	867903.ThesuDRAFT_00412	6.19e-46	172.0	COG0193@1|root,COG0193@2|Bacteria,1V3NB@1239|Firmicutes,24HMC@186801|Clostridia,3WCIX@538999|Clostridiales incertae sedis	186801|Clostridia	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
SX2_k127_3684899_4	545694.TREPR_1202	2.776e-49	193.0	COG0037@1|root,COG0037@2|Bacteria,2J638@203691|Spirochaetes	203691|Spirochaetes	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS_C
SX2_k127_3684899_0	744872.Spica_0794	2.184e-276	874.0	COG0465@1|root,COG0465@2|Bacteria,2J58Y@203691|Spirochaetes	203691|Spirochaetes	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
SX2_k127_3694542_1	565034.BHWA1_01335	2.16e-27	117.0	COG1664@1|root,COG1664@2|Bacteria,2J82J@203691|Spirochaetes	203691|Spirochaetes	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
SX2_k127_3694542_0	573413.Spirs_2373	2.965e-104	351.0	COG0664@1|root,COG4191@1|root,COG0664@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	hoxI	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	EAL,FliG_C,HATPase_c,HisKA,cNMP_binding
SX2_k127_3694542_2	1408436.JHXY01000010_gene850	1.494e-14	75.0	COG0034@1|root,COG0034@2|Bacteria,1TPH3@1239|Firmicutes,247RF@186801|Clostridia,25VI2@186806|Eubacteriaceae	186801|Clostridia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF_1	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7,Pribosyltran
SX2_k127_3702876_3	1047013.AQSP01000138_gene1034	5.263e-20	95.0	COG0789@1|root,COG0789@2|Bacteria	2|Bacteria	K	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding	-	-	4.6.1.1	ko:K01768,ko:K03713,ko:K11923,ko:K13638	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko03000	-	-	-	MerR_1
SX2_k127_3702876_2	573413.Spirs_3238	2.951e-32	129.0	COG1862@1|root,COG1862@2|Bacteria,2J8D6@203691|Spirochaetes	203691|Spirochaetes	U	Preprotein translocase, YajC subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
SX2_k127_3702876_0	665571.STHERM_c19500	9.963e-171	554.0	COG0342@1|root,COG0342@2|Bacteria,2J5UV@203691|Spirochaetes	203691|Spirochaetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
SX2_k127_3702876_1	1123274.KB899433_gene1343	2.18e-79	285.0	COG0341@1|root,COG0341@2|Bacteria,2J5N7@203691|Spirochaetes	203691|Spirochaetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
SX2_k127_3703150_1	616991.JPOO01000001_gene4601	1.526e-28	126.0	COG5580@1|root,COG5580@2|Bacteria,4PK53@976|Bacteroidetes,1I3SX@117743|Flavobacteriia	976|Bacteroidetes	O	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
SX2_k127_3703150_0	756499.Desde_2069	7.899e-41	157.0	COG0778@1|root,COG0778@2|Bacteria,1V0NJ@1239|Firmicutes,24FM7@186801|Clostridia,261PI@186807|Peptococcaceae	186801|Clostridia	C	PFAM Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	TM1586_NiRdase
SX2_k127_3726661_0	1211115.ALIQ01000198_gene465	4.286e-91	306.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VFM7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
SX2_k127_3726661_3	1121904.ARBP01000008_gene3235	4.392e-31	132.0	COG1802@1|root,COG1802@2|Bacteria,4NM2G@976|Bacteroidetes,47MD6@768503|Cytophagia	976|Bacteroidetes	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
SX2_k127_3726661_4	1121904.ARBP01000008_gene3235	1.052e-30	139.0	COG1802@1|root,COG1802@2|Bacteria,4NM2G@976|Bacteroidetes,47MD6@768503|Cytophagia	976|Bacteroidetes	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
SX2_k127_3726661_1	1111728.ATYS01000011_gene373	4.894e-59	222.0	COG3246@1|root,COG3246@2|Bacteria,1MZTP@1224|Proteobacteria,1RRUP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	quinone reductase	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
SX2_k127_3726661_2	1121346.KB899876_gene1732	3.903e-50	184.0	COG3822@1|root,COG3822@2|Bacteria,1V1ZU@1239|Firmicutes,4HHR0@91061|Bacilli,26W0Q@186822|Paenibacillaceae	91061|Bacilli	S	D-lyxose isomerase	-	-	5.3.1.15	ko:K09988	ko00040,map00040	-	R01898	RC00516	ko00000,ko00001,ko01000	-	-	-	Lyx_isomer
SX2_k127_373314_5	744872.Spica_0953	8.231e-18	84.0	COG0252@1|root,COG0252@2|Bacteria,2J7ZE@203691|Spirochaetes	203691|Spirochaetes	EJ	PFAM Asparaginase	-	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
SX2_k127_373314_2	456442.Mboo_0469	1.313e-111	377.0	COG0863@1|root,arCOG00115@2157|Archaea,2XT30@28890|Euryarchaeota,2NAWJ@224756|Methanomicrobia	224756|Methanomicrobia	L	to Modification methylase in Methanococcus jannaschii (Q58392) and Methanobacterium thermoformicicum (P29568)	-	-	2.1.1.113,2.1.1.72	ko:K00571,ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
SX2_k127_373314_4	926550.CLDAP_39570	2.214e-58	214.0	COG0543@1|root,COG0543@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	pyrK	-	1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14	ko:K00266,ko:K00528,ko:K02823	ko00240,ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00240,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248,R10159	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,Fer4_20,NAD_binding_1
SX2_k127_373314_3	926550.CLDAP_25040	9.542e-90	307.0	COG0167@1|root,COG0167@2|Bacteria,2G6RH@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
SX2_k127_373314_1	1128421.JAGA01000003_gene3015	6.812e-142	465.0	COG0284@1|root,COG0461@1|root,COG0284@2|Bacteria,COG0461@2|Bacteria,2NP92@2323|unclassified Bacteria	2|Bacteria	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrE	GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.10,4.1.1.23	ko:K00762,ko:K01591,ko:K13421	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00051	R00965,R01870,R08231	RC00063,RC00409,RC00611	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS17585,iYO844.BSU15560	OMPdecase,Pribosyltran
SX2_k127_373314_0	1499967.BAYZ01000061_gene5928	5.236e-299	927.0	COG2759@1|root,COG2759@2|Bacteria,2NP2R@2323|unclassified Bacteria	2|Bacteria	F	Formate--tetrahydrofolate ligase	fhs	GO:0000096,GO:0000097,GO:0000105,GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006520,GO:0006547,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009108,GO:0009110,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0052803,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.5,3.5.4.9,6.3.4.3	ko:K00288,ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00141,M00377	R00943,R01220,R01655	RC00026,RC00111,RC00202,RC00578	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FTHFS
SX2_k127_373314_6	1147.D082_18720	4.082e-11	73.0	COG0642@1|root,COG0745@1|root,COG0642@2|Bacteria,COG0745@2|Bacteria,1G1M7@1117|Cyanobacteria,1H54Y@1142|Synechocystis	1117|Cyanobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
SX2_k127_3747977_4	742738.HMPREF9460_00237	3.738e-34	132.0	COG0524@1|root,COG0524@2|Bacteria,1TRRY@1239|Firmicutes,248Y3@186801|Clostridia,2681M@186813|unclassified Clostridiales	186801|Clostridia	G	pfkB family carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
SX2_k127_3747977_2	665571.STHERM_c20410	2.183e-59	220.0	COG1638@1|root,COG1638@2|Bacteria,2J5PX@203691|Spirochaetes	203691|Spirochaetes	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
SX2_k127_3747977_1	521045.Kole_0981	5.109e-80	277.0	COG0524@1|root,COG0524@2|Bacteria,2GDS1@200918|Thermotogae	200918|Thermotogae	H	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
SX2_k127_3747977_3	573413.Spirs_2677	2.741e-57	214.0	COG2050@1|root,COG2050@2|Bacteria,2JAD0@203691|Spirochaetes	203691|Spirochaetes	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
SX2_k127_3747977_0	1167006.UWK_00068	1.547e-104	350.0	COG0545@1|root,COG0652@1|root,COG0545@2|Bacteria,COG0652@2|Bacteria,1RDA1@1224|Proteobacteria,43BUM@68525|delta/epsilon subdivisions,2WMFR@28221|Deltaproteobacteria,2MIPP@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C,Pro_isomerase
SX2_k127_3763067_11	1464048.JNZS01000038_gene3965	2.854e-24	117.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4D933@85008|Micromonosporales	201174|Actinobacteria	L	Belongs to the DEAD box helicase family	deaD	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360	3.6.4.13	ko:K05592,ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
SX2_k127_3763067_3	744872.Spica_0276	2.871e-104	372.0	COG2885@1|root,COG2885@2|Bacteria,2J6IG@203691|Spirochaetes	203691|Spirochaetes	M	ompA family	tpn50	-	-	-	-	-	-	-	-	-	-	-	OmpA
SX2_k127_3763067_6	28258.KP05_16940	7.131e-85	294.0	COG0583@1|root,COG0583@2|Bacteria,1MZX1@1224|Proteobacteria,1RNFR@1236|Gammaproteobacteria,1XH35@135619|Oceanospirillales	135619|Oceanospirillales	K	transcriptional regulator	-	-	-	ko:K02521	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
SX2_k127_3763067_1	926569.ANT_03280	2.675e-171	548.0	COG0059@1|root,COG0059@2|Bacteria,2G5NP@200795|Chloroflexi	200795|Chloroflexi	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
SX2_k127_3763067_0	665571.STHERM_c14560	4.219e-268	856.0	COG0129@1|root,COG0129@2|Bacteria	2|Bacteria	EG	dihydroxy-acid dehydratase activity	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1259,iECIAI39_1322.ECIAI39_3015	ILVD_EDD
SX2_k127_3763067_10	944480.ATUV01000002_gene166	1.697e-27	126.0	COG0664@1|root,COG0664@2|Bacteria,1MZZD@1224|Proteobacteria,42QUX@68525|delta/epsilon subdivisions,2WMWV@28221|Deltaproteobacteria,2M752@213113|Desulfurellales	28221|Deltaproteobacteria	K	Cyclic nucleotide-monophosphate binding domain	-	-	-	ko:K01420,ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
SX2_k127_3763067_7	635013.TherJR_2704	3.92e-44	163.0	COG1725@1|root,COG1725@2|Bacteria,1V9ZC@1239|Firmicutes,24NTW@186801|Clostridia,262CS@186807|Peptococcaceae	186801|Clostridia	K	PFAM Bacterial regulatory proteins, gntR family	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
SX2_k127_3763067_5	635013.TherJR_2703	1.32e-92	318.0	COG1131@1|root,COG1131@2|Bacteria,1TPZR@1239|Firmicutes,247NW@186801|Clostridia,2613B@186807|Peptococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX2_k127_3763067_4	290315.Clim_1980	7.988e-100	334.0	COG1145@1|root,COG1145@2|Bacteria,1FENI@1090|Chlorobi	1090|Chlorobi	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
SX2_k127_3763067_8	635013.TherJR_2506	3.379e-43	175.0	COG0500@1|root,COG2226@2|Bacteria,1V6QV@1239|Firmicutes,24JPQ@186801|Clostridia,267C0@186807|Peptococcaceae	186801|Clostridia	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
SX2_k127_3763067_9	333138.LQ50_19655	1.115e-40	171.0	COG1670@1|root,COG1670@2|Bacteria,1V4T4@1239|Firmicutes,4HGGP@91061|Bacilli,1ZGQ5@1386|Bacillus	91061|Bacilli	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_3
SX2_k127_3763067_2	1047013.AQSP01000142_gene195	2.716e-110	377.0	COG0787@1|root,COG0787@2|Bacteria,2NP3R@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
SX2_k127_3804725_5	1341151.ASZU01000009_gene931	1.61e-59	237.0	COG4821@1|root,COG4821@2|Bacteria,1TQS7@1239|Firmicutes,4HCR4@91061|Bacilli,27CJE@186824|Thermoactinomycetaceae	91061|Bacilli	S	SIS domain	-	-	-	-	-	-	-	-	-	-	-	-	SIS_2
SX2_k127_3804725_11	1166948.JPZL01000002_gene1454	1.552e-08	62.0	COG3090@1|root,COG3090@2|Bacteria,1N63U@1224|Proteobacteria,1SZU0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	ko:K21394	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctQ
SX2_k127_3804725_0	1121085.AUCI01000001_gene3737	1.737e-124	412.0	COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,4H9WK@91061|Bacilli,1ZC02@1386|Bacillus	91061|Bacilli	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
SX2_k127_3804725_4	1121085.AUCI01000001_gene3738	9.532e-64	235.0	COG1638@1|root,COG1638@2|Bacteria,1TP3I@1239|Firmicutes,4HD0U@91061|Bacilli,1ZCY6@1386|Bacillus	91061|Bacilli	G	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	DctP
SX2_k127_3804725_8	420324.KI911971_gene2980	1.312e-31	134.0	COG2186@1|root,COG2186@2|Bacteria,1R3Y8@1224|Proteobacteria,2U215@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
SX2_k127_3804725_3	1382304.JNIL01000001_gene2454	3.26e-65	232.0	COG4821@1|root,COG4821@2|Bacteria,1TQS7@1239|Firmicutes,4HCR4@91061|Bacilli	91061|Bacilli	S	protein containing SIS (Sugar ISomerase) phosphosugar binding domain	-	-	-	-	-	-	-	-	-	-	-	-	SIS_2
SX2_k127_3804725_2	1227488.C477_00490	8.581e-86	293.0	COG1082@1|root,arCOG01895@2157|Archaea	2157|Archaea	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SX2_k127_3804725_1	1298920.KI911353_gene824	2.617e-101	359.0	COG1874@1|root,COG1874@2|Bacteria,1VU26@1239|Firmicutes,24Z4M@186801|Clostridia,2216V@1506553|Lachnoclostridium	186801|Clostridia	G	Beta-galactosidase trimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_42,Glyco_hydro_42M
SX2_k127_3804725_10	478741.JAFS01000001_gene1447	9.449e-18	94.0	COG1082@1|root,COG1082@2|Bacteria,46VY2@74201|Verrucomicrobia,37GRU@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	G	Xylose isomerase-like TIM barrel	iolE	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SX2_k127_3804725_6	278957.ABEA03000091_gene678	6.689e-48	180.0	COG0673@1|root,COG0673@2|Bacteria,46YAS@74201|Verrucomicrobia,3K98D@414999|Opitutae	414999|Opitutae	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX2_k127_3804725_7	1408254.T458_09995	9.948e-32	142.0	COG2362@1|root,COG2362@2|Bacteria,1TSUZ@1239|Firmicutes,4HC5R@91061|Bacilli,26VQD@186822|Paenibacillaceae	1239|Firmicutes	E	D-aminopeptidase	-	-	-	ko:K16203	-	-	-	-	ko00000,ko01000,ko01002	3.A.1.5.2	-	-	Peptidase_M55
SX2_k127_3804725_12	867845.KI911784_gene2352	6.901e-05	54.0	COG2120@1|root,COG2120@2|Bacteria,2G6FB@200795|Chloroflexi,375NK@32061|Chloroflexia	32061|Chloroflexia	S	PFAM LmbE family protein	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
SX2_k127_3804725_9	1449126.JQKL01000013_gene3399	8.14e-19	91.0	COG0388@1|root,COG0388@2|Bacteria,1TQDK@1239|Firmicutes,24AWV@186801|Clostridia,269N4@186813|unclassified Clostridiales	186801|Clostridia	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
SX2_k127_3814966_2	688269.Theth_1581	4.73e-51	204.0	COG0426@1|root,COG0426@2|Bacteria,2GCAS@200918|Thermotogae	200918|Thermotogae	C	flavodoxin nitric oxide synthase	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Lactamase_B
SX2_k127_3814966_0	573413.Spirs_4114	2.118e-125	420.0	COG4166@1|root,COG4166@2|Bacteria,2J5KU@203691|Spirochaetes	203691|Spirochaetes	E	Bacterial extracellular solute-binding proteins, family 5	-	-	-	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
SX2_k127_3814966_4	889378.Spiaf_0084	1.714e-35	143.0	2FBC5@1|root,343I0@2|Bacteria,2J6WZ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_3814966_1	573413.Spirs_0298	8.329e-53	194.0	COG0705@1|root,COG0705@2|Bacteria,2J7HV@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
SX2_k127_3814966_3	744872.Spica_0348	2.231e-47	179.0	COG0293@1|root,COG0293@2|Bacteria,2J5SK@203691|Spirochaetes	203691|Spirochaetes	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	ftsJ	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
SX2_k127_3814966_5	1304872.JAGC01000003_gene2385	2.157e-26	122.0	COG1032@1|root,COG1032@2|Bacteria,1NRWP@1224|Proteobacteria,42S72@68525|delta/epsilon subdivisions,2WNA6@28221|Deltaproteobacteria,2M7RD@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
SX2_k127_3827507_1	1472716.KBK24_0102475	1.408e-22	114.0	COG1653@1|root,COG1653@2|Bacteria,1N4MG@1224|Proteobacteria,2W6UD@28216|Betaproteobacteria,1KCR9@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
SX2_k127_3827507_0	1499967.BAYZ01000009_gene5389	3.589e-131	432.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX2_k127_3827507_2	1042326.AZNV01000029_gene3560	8.165e-07	60.0	2CH5W@1|root,3020J@2|Bacteria,1Q73P@1224|Proteobacteria,2VD7X@28211|Alphaproteobacteria,4BIB8@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_382945_1	1480694.DC28_02505	5.389e-78	269.0	COG0653@1|root,COG0653@2|Bacteria,2J5UR@203691|Spirochaetes	203691|Spirochaetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
SX2_k127_382945_3	545695.TREAZ_2841	1.942e-33	143.0	COG0739@1|root,COG0739@2|Bacteria,2J5FR@203691|Spirochaetes	203691|Spirochaetes	M	LysM domain M23 M37 peptidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23
SX2_k127_382945_2	665571.STHERM_c07460	2.965e-73	263.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,2J6RF@203691|Spirochaetes	203691|Spirochaetes	M	LysM domain M23 M37 peptidase domain protein	nlpD	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23
SX2_k127_382945_0	1123274.KB899435_gene1312	3.161e-155	512.0	COG0768@1|root,COG0768@2|Bacteria,2J5D8@203691|Spirochaetes	203691|Spirochaetes	M	Cell division protein ftsI	pbp3	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
SX2_k127_3831426_0	906968.Trebr_0644	1.504e-164	532.0	COG1207@1|root,COG1207@2|Bacteria,2JBDX@203691|Spirochaetes	203691|Spirochaetes	M	Domain of unknown function (DUF4954)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4954
SX2_k127_3831426_4	28444.JODQ01000001_gene2386	1.525e-79	277.0	COG1879@1|root,COG1879@2|Bacteria,2I8KH@201174|Actinobacteria,4EM9C@85012|Streptosporangiales	201174|Actinobacteria	G	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
SX2_k127_3831426_1	1123075.AUDP01000048_gene1557	1.025e-155	507.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,3WMVK@541000|Ruminococcaceae	186801|Clostridia	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K10539	ko02010,map02010	M00213	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.2	-	-	ABC_tran
SX2_k127_3831426_6	537013.CLOSTMETH_03785	1.159e-66	254.0	COG1172@1|root,COG1172@2|Bacteria,1VW6R@1239|Firmicutes,2516G@186801|Clostridia,3WP5M@541000|Ruminococcaceae	186801|Clostridia	G	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
SX2_k127_3831426_5	1123075.AUDP01000048_gene1559	8.249e-71	251.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,249FA@186801|Clostridia,3WPIC@541000|Ruminococcaceae	186801|Clostridia	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
SX2_k127_3831426_2	632518.Calow_2148	1.738e-137	446.0	COG0407@1|root,COG0407@2|Bacteria,1UY51@1239|Firmicutes,24DZF@186801|Clostridia,42FW9@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX2_k127_3831426_3	760011.Spico_1067	1.412e-99	338.0	COG2211@1|root,COG2211@2|Bacteria,2JAUS@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX2_k127_3850154_0	573413.Spirs_2416	4.191e-71	263.0	COG0457@1|root,COG0457@2|Bacteria,2J58A@203691|Spirochaetes	203691|Spirochaetes	S	TPR domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_8
SX2_k127_3862383_2	1480694.DC28_03260	1.842e-79	272.0	COG0498@1|root,COG0498@2|Bacteria,2J63T@203691|Spirochaetes	203691|Spirochaetes	E	Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
SX2_k127_3862383_1	153721.MYP_1180	3.92e-99	332.0	COG0083@1|root,COG0083@2|Bacteria,4NE2M@976|Bacteroidetes,47KGY@768503|Cytophagia	976|Bacteroidetes	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	-	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
SX2_k127_3862383_0	665571.STHERM_c00530	2.165e-147	499.0	COG0527@1|root,COG0527@2|Bacteria,2J5C6@203691|Spirochaetes	203691|Spirochaetes	E	Amino acid kinase family	-	-	1.1.1.3,2.7.2.4	ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3
SX2_k127_3862383_3	1191523.MROS_1971	1.115e-66	229.0	COG0432@1|root,COG0432@2|Bacteria	2|Bacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
SX2_k127_3862383_5	880072.Desac_1950	4.911e-46	180.0	COG1560@1|root,COG1560@2|Bacteria	2|Bacteria	M	Kdo2-lipid A biosynthetic process	waaM	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
SX2_k127_3862383_6	1120998.AUFC01000002_gene2750	1.273e-39	168.0	COG3437@1|root,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,DUF3369,GGDEF,HD,HD_5,Response_reg
SX2_k127_3862383_4	880072.Desac_0427	4.694e-61	234.0	COG0784@1|root,COG1719@1|root,COG4191@1|root,COG0784@2|Bacteria,COG1719@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MRI2@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Signal transduction response regulator, receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg,dCache_1
SX2_k127_3862990_3	1168034.FH5T_20500	1.331e-13	84.0	COG1611@1|root,COG1611@2|Bacteria,4NGWU@976|Bacteroidetes,2FNYZ@200643|Bacteroidia	976|Bacteroidetes	S	Belongs to the LOG family	yvdD	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
SX2_k127_3862990_0	1304880.JAGB01000003_gene1027	0.0	1248.0	COG0383@1|root,COG0383@2|Bacteria,1TQEH@1239|Firmicutes,248VH@186801|Clostridia	186801|Clostridia	G	Glycosyl hydrolases family 38 C-terminal domain	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
SX2_k127_3862990_2	877418.ATWV01000008_gene725	7.918e-37	145.0	COG1438@1|root,COG1438@2|Bacteria,2J7NJ@203691|Spirochaetes	203691|Spirochaetes	K	Regulates arginine biosynthesis genes	argR	-	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
SX2_k127_3862990_1	665571.STHERM_c20030	7.819e-77	263.0	COG0002@1|root,COG0002@2|Bacteria,2J637@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
SX2_k127_386507_9	545695.TREAZ_0108	6.061e-10	59.0	2ERI0@1|root,33J3G@2|Bacteria,2J8XU@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_386507_7	1307761.L21SP2_1372	5.404e-34	147.0	COG0204@1|root,COG0204@2|Bacteria,2J6B7@203691|Spirochaetes	203691|Spirochaetes	I	Acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
SX2_k127_386507_5	309799.DICTH_1778	3.041e-62	229.0	COG0646@1|root,COG0646@2|Bacteria	2|Bacteria	E	methionine synthase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans
SX2_k127_386507_6	545695.TREAZ_2997	1.377e-42	171.0	COG1215@1|root,COG1215@2|Bacteria,2J6KZ@203691|Spirochaetes	203691|Spirochaetes	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SX2_k127_386507_8	573413.Spirs_1683	2.133e-30	130.0	COG0546@1|root,COG0546@2|Bacteria	2|Bacteria	S	glycolate biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
SX2_k127_386507_1	344747.PM8797T_31990	2.944e-141	461.0	COG3875@1|root,COG3875@2|Bacteria	2|Bacteria	S	lactate racemase activity	-	-	5.1.2.1	ko:K22373	ko00620,map00620	-	R01450	RC00519	ko00000,ko00001,ko01000	-	-	-	DUF2088
SX2_k127_386507_2	1408322.JHYK01000007_gene2094	3.681e-99	340.0	COG1055@1|root,COG1055@2|Bacteria,1TPNN@1239|Firmicutes,2494X@186801|Clostridia,27KNS@186928|unclassified Lachnospiraceae	186801|Clostridia	P	Arsenical pump membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
SX2_k127_386507_4	573413.Spirs_0448	7.563e-70	263.0	COG0778@1|root,COG0778@2|Bacteria,2JBC8@203691|Spirochaetes	203691|Spirochaetes	C	Nitroreductase family	sagB	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SX2_k127_386507_3	573413.Spirs_1138	4.108e-94	316.0	COG1028@1|root,COG1028@2|Bacteria	573413.Spirs_1138|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_386507_0	401526.TcarDRAFT_1906	1.246e-168	535.0	COG0362@1|root,COG0362@2|Bacteria,1TP4I@1239|Firmicutes,4H23Y@909932|Negativicutes	909932|Negativicutes	H	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
SX2_k127_3865243_1	1480694.DC28_09520	3.922e-132	429.0	COG1175@1|root,COG1175@2|Bacteria,2J5TH@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
SX2_k127_3865243_0	573413.Spirs_1368	7.373e-186	590.0	COG1653@1|root,COG1653@2|Bacteria,2J5W6@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
SX2_k127_3865243_7	1226325.HMPREF1548_06805	1.249e-19	101.0	COG4126@1|root,COG4126@2|Bacteria,1UKAT@1239|Firmicutes,25GR6@186801|Clostridia,36NCF@31979|Clostridiaceae	186801|Clostridia	E	Asp/Glu/Hydantoin racemase	-	-	-	-	-	-	-	-	-	-	-	-	Asp_Glu_race
SX2_k127_3865243_2	1380350.JIAP01000001_gene1433	9.872e-59	221.0	COG3958@1|root,COG3958@2|Bacteria,1N6QF@1224|Proteobacteria,2TTU8@28211|Alphaproteobacteria,43HQB@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
SX2_k127_3865243_3	1121428.DESHY_110537___1	1.189e-57	218.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,2607I@186807|Peptococcaceae	186801|Clostridia	G	PFAM Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
SX2_k127_3865243_5	158189.SpiBuddy_2664	3.209e-33	140.0	COG1802@1|root,COG1802@2|Bacteria,2J9GT@203691|Spirochaetes	203691|Spirochaetes	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
SX2_k127_3865243_6	926560.KE387023_gene2422	6.76e-24	119.0	COG0383@1|root,COG0383@2|Bacteria,1WMBK@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Alpha mannosidase, middle domain	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
SX2_k127_3865243_4	1040983.AXAE01000027_gene5194	9.05e-45	175.0	COG0395@1|root,COG0395@2|Bacteria,1QHIK@1224|Proteobacteria,2U2IY@28211|Alphaproteobacteria,43I49@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	ABC-type sugar transport system, permease component	-	-	-	ko:K02026,ko:K10119	ko02010,map02010	M00196,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.28	-	-	BPD_transp_1
SX2_k127_3865243_8	472175.EL18_00381	9.229e-06	49.0	COG1175@1|root,COG1175@2|Bacteria,1MVAP@1224|Proteobacteria,2TSNP@28211|Alphaproteobacteria,43JHH@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025,ko:K10193	ko02010,map02010	M00202,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.11	-	-	BPD_transp_1
SX2_k127_3868826_0	876269.ARWA01000001_gene1525	1.286e-68	243.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2TR1V@28211|Alphaproteobacteria,3NC06@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.12.1.2,1.6.5.3	ko:K00335,ko:K18005	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
SX2_k127_3868826_1	330214.NIDE0628	1.127e-12	77.0	COG0810@1|root,COG0810@2|Bacteria,3J0U0@40117|Nitrospirae	40117|Nitrospirae	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
SX2_k127_3868826_2	1313304.CALK_1652	2.929e-08	58.0	COG0848@1|root,COG0848@2|Bacteria	2|Bacteria	U	biopolymer transport protein	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
SX2_k127_3879665_0	573413.Spirs_2610	1.064e-208	663.0	COG1256@1|root,COG4786@1|root,COG1256@2|Bacteria,COG4786@2|Bacteria,2J5TQ@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook-associated protein, FlgK	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_IN,Flg_bbr_C
SX2_k127_3883968_4	596152.DesU5LDRAFT_3636	1.796e-08	60.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,42V9Q@68525|delta/epsilon subdivisions,2WRRT@28221|Deltaproteobacteria,2MCID@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM RNP-1 like RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
SX2_k127_3883968_0	665571.STHERM_c20060	1.482e-183	602.0	COG0137@1|root,COG0137@2|Bacteria,2J5QQ@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
SX2_k127_3883968_1	665571.STHERM_c20050	5.078e-124	421.0	COG4992@1|root,COG4992@2|Bacteria,2J5X2@203691|Spirochaetes	203691|Spirochaetes	E	PFAM aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SX2_k127_3883968_2	1480694.DC28_03495	5.773e-56	211.0	COG0548@1|root,COG0548@2|Bacteria,2J6RN@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
SX2_k127_3883968_3	665571.STHERM_c20030	9.703e-47	172.0	COG0002@1|root,COG0002@2|Bacteria,2J637@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
SX2_k127_3889366_0	573413.Spirs_3206	6.178e-86	317.0	COG1729@1|root,COG3071@1|root,COG4105@1|root,COG1729@2|Bacteria,COG3071@2|Bacteria,COG4105@2|Bacteria,2J6SG@203691|Spirochaetes	203691|Spirochaetes	H	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
SX2_k127_3889366_3	573413.Spirs_3205	7.471e-15	88.0	2CA9B@1|root,34495@2|Bacteria,2J5SX@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_3889366_1	573413.Spirs_3204	1.447e-75	260.0	COG0811@1|root,COG0811@2|Bacteria,2J700@203691|Spirochaetes	203691|Spirochaetes	U	MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
SX2_k127_3889366_2	744872.Spica_2113	1.4e-29	122.0	COG0848@1|root,COG0848@2|Bacteria,2J82R@203691|Spirochaetes	203691|Spirochaetes	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
SX2_k127_3890378_2	1123274.KB899409_gene429	6.013e-38	149.0	COG1664@1|root,COG1664@2|Bacteria,2J861@203691|Spirochaetes	203691|Spirochaetes	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
SX2_k127_3890378_1	573413.Spirs_1515	1.525e-51	197.0	COG0457@1|root,COG0457@2|Bacteria,2J7IN@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC3,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
SX2_k127_3890378_0	573413.Spirs_1516	1.428e-110	374.0	COG0621@1|root,COG0621@2|Bacteria,2J5SB@203691|Spirochaetes	203691|Spirochaetes	J	Radical SAM methylthiotransferase, MiaB RimO family	yqeV	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
SX2_k127_3898373_1	665571.STHERM_c04240	8.901e-98	328.0	COG1052@1|root,COG1052@2|Bacteria	2|Bacteria	CH	NAD binding	-	-	1.1.1.399,1.1.1.95	ko:K00058,ko:K04496	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,ko04310,ko04330,ko05200,ko05220,map00260,map00680,map01100,map01120,map01130,map01200,map01230,map04310,map04330,map05200,map05220	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
SX2_k127_3898373_2	1304880.JAGB01000001_gene865	2.817e-93	327.0	COG0673@1|root,COG0673@2|Bacteria,1UIIC@1239|Firmicutes,249KE@186801|Clostridia	186801|Clostridia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
SX2_k127_3898373_0	1499967.BAYZ01000143_gene6126	2.516e-144	471.0	COG1228@1|root,COG1228@2|Bacteria	2|Bacteria	Q	imidazolonepropionase activity	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
SX2_k127_3931774_0	573413.Spirs_0980	7.027e-152	487.0	COG0202@1|root,COG0202@2|Bacteria,2J58K@203691|Spirochaetes	203691|Spirochaetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
SX2_k127_3931774_1	665571.STHERM_c05220	2.953e-40	155.0	COG0203@1|root,COG0203@2|Bacteria,2J841@203691|Spirochaetes	203691|Spirochaetes	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
SX2_k127_3931774_2	545695.TREAZ_2842	2.61e-30	134.0	COG3064@1|root,COG3064@2|Bacteria,2J6Q1@203691|Spirochaetes	203691|Spirochaetes	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_3934404_0	744872.Spica_1604	4.173e-233	729.0	COG1158@1|root,COG1158@2|Bacteria,2J5BW@203691|Spirochaetes	203691|Spirochaetes	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
SX2_k127_3934404_19	537013.CLOSTMETH_02108	9.291e-33	128.0	COG0254@1|root,COG0254@2|Bacteria,1VEGU@1239|Firmicutes,24QNZ@186801|Clostridia,3WKI1@541000|Ruminococcaceae	186801|Clostridia	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
SX2_k127_3934404_18	665571.STHERM_c21280	5.811e-43	173.0	COG1656@1|root,COG1656@2|Bacteria	2|Bacteria	F	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C,Ub-Mut7C
SX2_k127_3934404_24	243276.TPANIC_0262	1.144e-12	77.0	COG0664@1|root,COG0664@2|Bacteria,2J6ZR@203691|Spirochaetes	203691|Spirochaetes	K	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
SX2_k127_3934404_26	1192034.CAP_2385	0.0004643	48.0	COG0659@1|root,COG0664@1|root,COG0659@2|Bacteria,COG0664@2|Bacteria,1MVWV@1224|Proteobacteria	1224|Proteobacteria	P	COG0659 Sulfate permease and related transporters (MFS superfamily	bicA	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp,cNMP_binding
SX2_k127_3934404_7	573413.Spirs_3175	8.393e-111	373.0	COG0153@1|root,COG0153@2|Bacteria,2J58W@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the GHMP kinase family	-	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
SX2_k127_3934404_14	1123274.KB899429_gene2901	8.867e-74	255.0	COG0496@1|root,COG0496@2|Bacteria,2J7HR@203691|Spirochaetes	203691|Spirochaetes	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
SX2_k127_3934404_17	573413.Spirs_3173	6.085e-52	204.0	COG0457@1|root,COG0457@2|Bacteria,2J6BA@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_16,TPR_2,TPR_6,TPR_8
SX2_k127_3934404_8	243276.TPANIC_0421	6.776e-109	377.0	COG0457@1|root,COG3391@1|root,COG0457@2|Bacteria,COG3391@2|Bacteria,2J5QG@203691|Spirochaetes	203691|Spirochaetes	S	NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	NHL,TPR_11
SX2_k127_3934404_15	935948.KE386495_gene1221	1.834e-69	243.0	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia,42FJI@68295|Thermoanaerobacterales	186801|Clostridia	S	Methionine synthase B12-binding module cap domain protein	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
SX2_k127_3934404_23	1123274.KB899408_gene3944	5.736e-17	87.0	COG1146@1|root,COG1146@2|Bacteria,2J9EV@203691|Spirochaetes	203691|Spirochaetes	C	4Fe-4S binding domain	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_7
SX2_k127_3934404_4	1123274.KB899408_gene3945	2.642e-144	465.0	COG0674@1|root,COG0674@2|Bacteria,2J65R@203691|Spirochaetes	203691|Spirochaetes	C	oxidoreductase, alpha subunit	porA6	-	1.2.7.11,1.2.7.3,1.2.7.7	ko:K00174,ko:K00186	ko00010,ko00020,ko00280,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197,R07160,R08566,R08567	RC00004,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
SX2_k127_3934404_6	1123274.KB899408_gene3946	1.104e-111	367.0	COG1013@1|root,COG1013@2|Bacteria,2J6R4@203691|Spirochaetes	203691|Spirochaetes	C	oxidoreductase beta subunit	-	-	1.2.7.11,1.2.7.3,1.2.7.7	ko:K00175,ko:K00187	ko00010,ko00020,ko00280,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197,R07160,R08566,R08567	RC00004,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
SX2_k127_3934404_16	1123274.KB899408_gene3947	3.406e-56	212.0	COG1014@1|root,COG1014@2|Bacteria,2J8M0@203691|Spirochaetes	203691|Spirochaetes	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
SX2_k127_3934404_25	1115632.JAFW01000001_gene4357	1.21e-06	59.0	2E64T@1|root,330TJ@2|Bacteria,2H60Q@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_3934404_22	742818.HMPREF9451_00333	4.591e-20	102.0	COG2983@1|root,COG2983@2|Bacteria	2|Bacteria	S	Putative zinc- or iron-chelating domain	ycgN	-	-	ko:K09160	-	-	-	-	ko00000	-	-	-	CxxCxxCC
SX2_k127_3934404_3	237368.SCABRO_00441	4.625e-146	484.0	COG1236@1|root,COG1236@2|Bacteria,2IXNS@203682|Planctomycetes	203682|Planctomycetes	J	Exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_2,Lactamase_B_6,RMMBL
SX2_k127_3934404_1	744872.Spica_1665	5.009e-175	582.0	COG0572@1|root,COG0572@2|Bacteria,2J578@203691|Spirochaetes	203691|Spirochaetes	F	PFAM Phosphoribulokinase Uridine kinase family	-	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
SX2_k127_3934404_13	1480694.DC28_03140	9.248e-75	265.0	COG2206@1|root,COG2206@2|Bacteria,2J6CD@203691|Spirochaetes	203691|Spirochaetes	T	HD domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
SX2_k127_3934404_21	545695.TREAZ_3607	1.713e-25	116.0	2F691@1|root,33YSU@2|Bacteria,2J6FP@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_3934404_12	1307761.L21SP2_2857	1.865e-78	278.0	COG0609@1|root,COG0609@2|Bacteria,2J6D8@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
SX2_k127_3934404_11	889378.Spiaf_2248	2.115e-94	334.0	COG1120@1|root,COG1120@2|Bacteria,2J7N3@203691|Spirochaetes	203691|Spirochaetes	HP	ATPases associated with a variety of cellular activities	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
SX2_k127_3934404_5	1123274.KB899423_gene1590	1.685e-117	388.0	COG1816@1|root,COG1816@2|Bacteria,2J5HJ@203691|Spirochaetes	203691|Spirochaetes	F	Adenosine AMP deaminase	add	-	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
SX2_k127_3934404_20	545695.TREAZ_0947	1.068e-32	137.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,2J72G@203691|Spirochaetes	203691|Spirochaetes	M	LysM domain M23 M37 peptidase domain protein	lysM	-	-	ko:K06194	-	-	-	-	ko00000	1.A.34.1.2	-	-	Amidase_3,LysM,Peptidase_M23
SX2_k127_3934404_10	545694.TREPR_2469	1.734e-103	347.0	COG0568@1|root,COG0568@2|Bacteria,2J71G@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
SX2_k127_3934404_2	744872.Spica_0771	3.151e-149	483.0	COG0402@1|root,COG0402@2|Bacteria,2J6KS@203691|Spirochaetes	203691|Spirochaetes	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
SX2_k127_3934404_9	573413.Spirs_1736	9.706e-108	359.0	COG0664@1|root,COG1729@1|root,COG0664@2|Bacteria,COG1729@2|Bacteria,2J5MQ@203691|Spirochaetes	203691|Spirochaetes	T	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_16,TPR_2,TPR_6,TPR_8,cNMP_binding
SX2_k127_3944568_4	1125863.JAFN01000001_gene2916	4.26e-20	94.0	COG0347@1|root,COG0347@2|Bacteria,1NPUT@1224|Proteobacteria,42WWB@68525|delta/epsilon subdivisions,2WTEG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Belongs to the P(II) protein family	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_3944568_0	889378.Spiaf_0246	7.423e-116	381.0	COG0332@1|root,COG0332@2|Bacteria,2J6DC@203691|Spirochaetes	203691|Spirochaetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
SX2_k127_3944568_1	665571.STHERM_c21550	4.865e-96	323.0	COG0331@1|root,COG0331@2|Bacteria,2J5E6@203691|Spirochaetes	203691|Spirochaetes	I	Malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
SX2_k127_3944568_3	665571.STHERM_c21540	8.621e-77	271.0	COG1028@1|root,COG1028@2|Bacteria,2J6CJ@203691|Spirochaetes	203691|Spirochaetes	IQ	PFAM Short-chain dehydrogenase reductase SDR	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SX2_k127_3944568_2	158190.SpiGrapes_1491	1.324e-78	282.0	COG0304@1|root,COG0304@2|Bacteria,2J5H7@203691|Spirochaetes	203691|Spirochaetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
SX2_k127_3946677_1	665571.STHERM_c19290	3.62e-63	236.0	COG2890@1|root,COG2890@2|Bacteria,2J7VJ@203691|Spirochaetes	203691|Spirochaetes	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
SX2_k127_3946677_0	744872.Spica_0421	3.183e-106	348.0	COG0216@1|root,COG0216@2|Bacteria,2J5KY@203691|Spirochaetes	203691|Spirochaetes	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
SX2_k127_3948047_1	709797.CSIRO_0323	4.941e-60	210.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,2TR3W@28211|Alphaproteobacteria,3JU8E@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	Belongs to the CarA family	carA	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
SX2_k127_3948047_0	290397.Adeh_1729	6.053e-249	784.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2WJQH@28221|Deltaproteobacteria,2YUKG@29|Myxococcales	28221|Deltaproteobacteria	F	Carbamoyl-phosphate synthetase ammonia chain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
SX2_k127_3958422_2	644282.Deba_2839	8.693e-40	152.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	-	-	1.12.1.3,1.6.5.3	ko:K00124,ko:K00335,ko:K18331	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
SX2_k127_3958422_0	1499967.BAYZ01000171_gene5567	0.0	1346.0	COG1148@1|root,COG4231@1|root,COG1148@2|Bacteria,COG4231@2|Bacteria	2|Bacteria	C	indolepyruvate ferredoxin oxidoreductase activity	bamE	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_oxidored,Fer4,Fer4_20,Fer4_7,Pyr_redox_2
SX2_k127_3958422_1	1499967.BAYZ01000171_gene5568	5.566e-63	231.0	COG1908@1|root,COG1908@2|Bacteria,2NPFI@2323|unclassified Bacteria	2|Bacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	hdrG	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
SX2_k127_3958422_3	1499967.BAYZ01000171_gene5570	3.165e-30	130.0	COG4656@1|root,COG4656@2|Bacteria	2|Bacteria	C	electron transfer activity	citB	-	-	ko:K03616,ko:K13795	-	-	-	-	ko00000	-	-	-	CCG,Complex1_51K,Fer4,Fer4_17,Fer4_21,Fer4_8,FrhB_FdhB_C
SX2_k127_3971794_0	573413.Spirs_2249	6.184e-121	409.0	COG1593@1|root,COG3090@1|root,COG1593@2|Bacteria,COG3090@2|Bacteria,2J5NW@203691|Spirochaetes	203691|Spirochaetes	G	transporter, DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
SX2_k127_3971794_1	545695.TREAZ_1763	2.789e-34	140.0	COG1638@1|root,COG1638@2|Bacteria,2J5PX@203691|Spirochaetes	203691|Spirochaetes	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
SX2_k127_3978949_0	665571.STHERM_c07480	1.447e-317	984.0	COG0653@1|root,COG0653@2|Bacteria,2J5UR@203691|Spirochaetes	203691|Spirochaetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
SX2_k127_3978949_2	573413.Spirs_2624	1.031e-66	242.0	2CK99@1|root,3464J@2|Bacteria,2J60S@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_3978949_1	158190.SpiGrapes_3055	8.491e-69	259.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2J5T7@203691|Spirochaetes	203691|Spirochaetes	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
SX2_k127_3978949_3	1321815.HMPREF9193_00923	3.067e-13	76.0	2FC9X@1|root,344DK@2|Bacteria,2J8C9@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_399828_1	483219.LILAB_23865	4.644e-79	282.0	COG4249@1|root,COG4249@2|Bacteria,1QX7K@1224|Proteobacteria,43AHW@68525|delta/epsilon subdivisions,2X5Y0@28221|Deltaproteobacteria,2YZCA@29|Myxococcales	28221|Deltaproteobacteria	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
SX2_k127_399828_4	313603.FB2170_10971	5.907e-05	53.0	COG3595@1|root,COG3595@2|Bacteria,4NNN5@976|Bacteroidetes,1I27D@117743|Flavobacteriia	976|Bacteroidetes	S	Putative auto-transporter adhesin, head GIN domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2807
SX2_k127_399828_0	309807.SRU_0981	9.5e-183	586.0	COG1070@1|root,COG1070@2|Bacteria,4NFBZ@976|Bacteroidetes,1FJZS@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	FGGY family of carbohydrate kinases, C-terminal domain	xylB_2	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
SX2_k127_399828_3	1123229.AUBC01000029_gene3529	5.69e-16	88.0	COG0524@1|root,COG0524@2|Bacteria,1MXSY@1224|Proteobacteria,2TR08@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG0524 Sugar kinases, ribokinase family	psuK	-	2.7.1.83	ko:K16328	ko00240,map00240	-	R03315	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	HTH_24,PfkB
SX2_k127_399828_2	1408422.JHYF01000013_gene561	6.767e-42	159.0	COG2313@1|root,COG2313@2|Bacteria,1TR5J@1239|Firmicutes,247J8@186801|Clostridia,36F77@31979|Clostridiaceae	186801|Clostridia	Q	Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway	psuG	-	4.2.1.70	ko:K16329	ko00240,map00240	-	R01055	RC00432,RC00433	ko00000,ko00001,ko01000	-	-	-	Indigoidine_A
SX2_k127_4001181_1	545694.TREPR_1911	1.995e-57	203.0	COG1197@1|root,COG1197@2|Bacteria,2J63X@203691|Spirochaetes	203691|Spirochaetes	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
SX2_k127_4001181_0	744872.Spica_1248	1.743e-167	539.0	COG0448@1|root,COG0448@2|Bacteria,2J5UB@203691|Spirochaetes	203691|Spirochaetes	H	Glucose-1-phosphate adenylyltransferase	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
SX2_k127_4001181_2	1307761.L21SP2_1222	8.03e-45	168.0	COG1205@1|root,COG1205@2|Bacteria,2J5DK@203691|Spirochaetes	203691|Spirochaetes	L	DEAD DEAH box helicase	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
SX2_k127_4001956_14	545695.TREAZ_0340	2.324e-23	104.0	COG1344@1|root,COG1344@2|Bacteria,2J5NR@203691|Spirochaetes	203691|Spirochaetes	N	Component of the core of the flagella	flaB3	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
SX2_k127_4001956_0	545694.TREPR_0296	5.22e-137	444.0	COG1344@1|root,COG1344@2|Bacteria,2J5TJ@203691|Spirochaetes	203691|Spirochaetes	N	Component of the core of the flagella	flaB3	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
SX2_k127_4001956_5	744872.Spica_0674	1.255e-94	322.0	COG0457@1|root,COG0457@2|Bacteria,2J5UY@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_7,TPR_8
SX2_k127_4001956_13	1123274.KB899419_gene1894	9.255e-58	212.0	2920H@1|root,2ZPJT@2|Bacteria,2J5PN@203691|Spirochaetes	203691|Spirochaetes	S	Pilus assembly protein PilZ	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
SX2_k127_4001956_12	1499967.BAYZ01000155_gene652	4.881e-60	221.0	COG0524@1|root,COG0524@2|Bacteria	2|Bacteria	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	pfkB	-	2.7.1.15,2.7.1.4	ko:K00847,ko:K00852	ko00030,ko00051,ko00500,ko00520,ko01100,map00030,map00051,map00500,map00520,map01100	-	R00760,R00867,R01051,R02750,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
SX2_k127_4001956_3	871963.Desdi_2713	4.478e-116	393.0	COG0282@1|root,COG0282@2|Bacteria,1TQ22@1239|Firmicutes,248ZM@186801|Clostridia,26084@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
SX2_k127_4001956_8	439235.Dalk_5277	2.605e-88	316.0	COG3191@1|root,COG3191@2|Bacteria,1MWDP@1224|Proteobacteria,42QPY@68525|delta/epsilon subdivisions,2WMQC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EQ	PFAM Peptidase family S58	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S58
SX2_k127_4001956_6	1121403.AUCV01000045_gene1128	1.532e-92	328.0	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,42MES@68525|delta/epsilon subdivisions,2WIQK@28221|Deltaproteobacteria,2MIUS@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
SX2_k127_4001956_9	401526.TcarDRAFT_1939	3.184e-80	277.0	COG1893@1|root,COG1893@2|Bacteria,1UM1M@1239|Firmicutes,4H595@909932|Negativicutes	909932|Negativicutes	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	-	-	-	-	-	-	-	-	-	-	ApbA,ApbA_C
SX2_k127_4001956_2	562970.Btus_3056	1.486e-128	422.0	COG0624@1|root,COG0624@2|Bacteria,1TPMJ@1239|Firmicutes,4HB39@91061|Bacilli,279ND@186823|Alicyclobacillaceae	91061|Bacilli	E	Peptidase dimerisation domain	dapE_3	-	3.5.1.16,3.5.1.18	ko:K01438,ko:K01439	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00669,R02734,R09107	RC00064,RC00090,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
SX2_k127_4001956_11	78245.Xaut_4055	3.869e-61	223.0	COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,1MUTY@1224|Proteobacteria,2TQVU@28211|Alphaproteobacteria,3F0JX@335928|Xanthobacteraceae	28211|Alphaproteobacteria	P	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
SX2_k127_4001956_7	545694.TREPR_0441	5.774e-92	308.0	COG0410@1|root,COG0410@2|Bacteria,2J5VQ@203691|Spirochaetes	203691|Spirochaetes	E	ABC-type branched-chain amino acid transport systems ATPase component	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
SX2_k127_4001956_4	545694.TREPR_0442	4.706e-104	345.0	COG0559@1|root,COG0559@2|Bacteria	2|Bacteria	E	leucine import across plasma membrane	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
SX2_k127_4001956_10	545694.TREPR_0443	3.667e-77	268.0	COG4177@1|root,COG4177@2|Bacteria	2|Bacteria	E	L-phenylalanine transmembrane transporter activity	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
SX2_k127_4001956_1	545694.TREPR_0444	1.044e-134	453.0	COG0683@1|root,COG0683@2|Bacteria	2|Bacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
SX2_k127_4012158_2	479433.Caci_4917	5.972e-13	70.0	COG3875@1|root,COG3875@2|Bacteria,2I9JU@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
SX2_k127_4012158_0	1234364.AMSF01000040_gene43	8.375e-117	409.0	COG1305@1|root,COG1305@2|Bacteria,1R5Q7@1224|Proteobacteria,1RPH2@1236|Gammaproteobacteria,1X672@135614|Xanthomonadales	135614|Xanthomonadales	E	Domain of Unknown Function with PDB structure (DUF3857)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857
SX2_k127_4012158_1	1009370.ALO_16277	2.072e-25	106.0	COG2193@1|root,COG2193@2|Bacteria	2|Bacteria	P	ferroxidase activity	bfr	GO:0003674,GO:0003824,GO:0004322,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0033212,GO:0033214,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0098771	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
SX2_k127_402597_7	906968.Trebr_0172	6.45e-06	52.0	COG2193@1|root,COG2193@2|Bacteria	2|Bacteria	P	ferroxidase activity	bfr	GO:0003674,GO:0003824,GO:0004322,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0033212,GO:0033214,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0098771	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
SX2_k127_402597_2	1167006.UWK_01188	3.199e-76	264.0	COG2316@1|root,COG2316@2|Bacteria,1RA50@1224|Proteobacteria,42QZZ@68525|delta/epsilon subdivisions,2WMUN@28221|Deltaproteobacteria,2MJHQ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
SX2_k127_402597_5	517418.Ctha_2508	2.015e-29	124.0	COG3118@1|root,COG3118@2|Bacteria,1FE4C@1090|Chlorobi	1090|Chlorobi	O	Belongs to the thioredoxin family	-	-	1.8.1.8	ko:K03671,ko:K03672	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko01000,ko03110	-	-	-	Thioredoxin
SX2_k127_402597_4	1122221.JHVI01000004_gene147	6.949e-40	166.0	2CMS6@1|root,32SFE@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
SX2_k127_402597_6	930171.Asphe3_21010	1.44e-06	57.0	COG0716@1|root,COG0716@2|Bacteria	2|Bacteria	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Flavodoxin_3,Flavodoxin_5
SX2_k127_402597_3	1541959.KQ51_00260	6.261e-44	173.0	2E6H4@1|root,3314B@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_402597_0	349741.Amuc_0958	1.161e-87	299.0	COG0708@1|root,COG0708@2|Bacteria,46TGT@74201|Verrucomicrobia,2IU1A@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Endonuclease/Exonuclease/phosphatase family	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
SX2_k127_402597_1	744872.Spica_1257	1.436e-80	293.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SX2_k127_4032497_7	545695.TREAZ_0887	0.0001318	46.0	COG2882@1|root,COG2882@2|Bacteria,2J8SK@203691|Spirochaetes	203691|Spirochaetes	N	flagellar export protein FliJ	fliJ	-	-	ko:K02413	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliJ
SX2_k127_4032497_2	744872.Spica_1540	1.228e-46	175.0	COG3334@1|root,COG3334@2|Bacteria,2J66F@203691|Spirochaetes	203691|Spirochaetes	S	PFAM MgtE intracellular	flbB	-	-	ko:K02383	-	-	-	-	ko00000,ko02035	-	-	-	-
SX2_k127_4032497_6	744872.Spica_1539	6.529e-15	87.0	COG3144@1|root,COG3144@2|Bacteria	2|Bacteria	N	bacterial-type flagellum assembly	flbC	-	-	ko:K02384,ko:K02414	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_hook
SX2_k127_4032497_4	545694.TREPR_2864	7.922e-42	158.0	COG1843@1|root,COG1843@2|Bacteria,2J806@203691|Spirochaetes	203691|Spirochaetes	N	flagellar hook	flgD	-	-	ko:K02389	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgD
SX2_k127_4032497_0	1123274.KB899413_gene847	2.379e-209	660.0	COG1749@1|root,COG1749@2|Bacteria,2J5H4@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook protein flgE	flgE	-	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlaE,Flg_bb_rod,Flg_bbr_C
SX2_k127_4032497_5	889378.Spiaf_2096	5.393e-29	116.0	COG1582@1|root,COG1582@2|Bacteria,2J8UC@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar protein FlbD	flbD	-	-	ko:K02385	-	-	-	-	ko00000,ko02035	-	-	-	FlbD
SX2_k127_4032497_1	665571.STHERM_c09200	4.98e-91	310.0	COG1291@1|root,COG1291@2|Bacteria,2J5HT@203691|Spirochaetes	203691|Spirochaetes	N	MotA TolQ ExbB proton channel family	motA	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
SX2_k127_4032497_3	665571.STHERM_c09210	5.897e-45	167.0	COG1360@1|root,COG1360@2|Bacteria,2J68Q@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar motor protein	motB	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
SX2_k127_4044839_5	309799.DICTH_1607	3.931e-09	61.0	COG2331@1|root,COG2331@2|Bacteria	2|Bacteria	P	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
SX2_k127_4044839_1	545695.TREAZ_2139	4.735e-48	188.0	COG1847@1|root,COG1847@2|Bacteria,2J5S0@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Single-stranded nucleic acid binding R3H	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
SX2_k127_4044839_0	1123274.KB899423_gene1599	7.151e-115	392.0	COG0706@1|root,COG0706@2|Bacteria,2J5HA@203691|Spirochaetes	203691|Spirochaetes	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
SX2_k127_4044839_2	207559.Dde_2395	1.325e-23	107.0	COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,42VNC@68525|delta/epsilon subdivisions,2WRIM@28221|Deltaproteobacteria,2MD5H@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
SX2_k127_4044839_4	1125699.HMPREF9194_00037	1.263e-10	66.0	COG0594@1|root,COG0594@2|Bacteria	2|Bacteria	J	ribonuclease P activity	rnpA	GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031123,GO:0031404,GO:0031974,GO:0031981,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043628,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904	3.1.26.5	ko:K03536,ko:K08998	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
SX2_k127_4044839_3	1321815.HMPREF9193_02034	7e-12	65.0	COG0230@1|root,COG0230@2|Bacteria,2J8S9@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
SX2_k127_4072169_5	545695.TREAZ_2842	1.678e-28	133.0	COG3064@1|root,COG3064@2|Bacteria,2J6Q1@203691|Spirochaetes	203691|Spirochaetes	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4072169_0	744872.Spica_2759	2.375e-225	710.0	COG1418@1|root,COG1418@2|Bacteria,2J5IM@203691|Spirochaetes	203691|Spirochaetes	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
SX2_k127_4072169_1	1123274.KB899431_gene3253	2.01e-93	314.0	COG1692@1|root,COG1692@2|Bacteria,2J7C4@203691|Spirochaetes	203691|Spirochaetes	S	metallophosphoesterase	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
SX2_k127_4072169_3	1121472.AQWN01000003_gene1567	1.764e-46	179.0	COG1189@1|root,COG1189@2|Bacteria,1TPE4@1239|Firmicutes,247VH@186801|Clostridia,260Y5@186807|Peptococcaceae	186801|Clostridia	J	TIGRFAM hemolysin TlyA family protein	rrmJ	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
SX2_k127_4072169_4	665571.STHERM_c13000	2.967e-42	165.0	COG5401@1|root,COG5401@2|Bacteria,2J7JQ@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane
SX2_k127_4072169_2	573413.Spirs_3210	1.439e-51	200.0	COG1080@1|root,COG1080@2|Bacteria,2J5FB@203691|Spirochaetes	203691|Spirochaetes	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
SX2_k127_4079443_0	309798.COPRO5265_0007	4.556e-208	654.0	COG1328@1|root,COG1328@2|Bacteria,1TR9K@1239|Firmicutes,247WF@186801|Clostridia,42ET1@68295|Thermoanaerobacterales	186801|Clostridia	F	TIGRFAM anaerobic ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,Glutaredoxin,NRDD
SX2_k127_4079443_5	1123226.KB899277_gene1519	5.194e-25	117.0	COG0737@1|root,COG0737@2|Bacteria,1TQCW@1239|Firmicutes,4HAUC@91061|Bacilli,26TF3@186822|Paenibacillaceae	91061|Bacilli	F	Belongs to the 5'-nucleotidase family	yunD	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid_C,Metallophos
SX2_k127_4079443_6	1304874.JAFY01000002_gene902	4.308e-19	96.0	COG0737@1|root,COG0737@2|Bacteria,3TB3Q@508458|Synergistetes	508458|Synergistetes	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.5,3.6.1.45	ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
SX2_k127_4079443_4	1157490.EL26_06000	2.236e-25	120.0	COG1657@1|root,COG1657@2|Bacteria	2|Bacteria	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,DUF1194,DUF4159,Methyltransf_23,Prenyltrans,SLH,SQHop_cyclase_C
SX2_k127_4079443_7	448385.sce5048	4.514e-06	51.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,4377A@68525|delta/epsilon subdivisions,2X27V@28221|Deltaproteobacteria,2YXVZ@29|Myxococcales	28221|Deltaproteobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SX2_k127_4079443_2	1382306.JNIM01000001_gene2968	2.411e-140	465.0	COG1070@1|root,COG1070@2|Bacteria,2G7ND@200795|Chloroflexi	200795|Chloroflexi	G	FGGY family of carbohydrate kinases, N-terminal domain	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
SX2_k127_4079443_1	1122918.KB907273_gene3530	3.066e-186	602.0	COG0747@1|root,COG0747@2|Bacteria,1TXR4@1239|Firmicutes,4I6SP@91061|Bacilli,26UR3@186822|Paenibacillaceae	91061|Bacilli	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
SX2_k127_4079443_3	383372.Rcas_2453	7.142e-32	128.0	COG0601@1|root,COG0601@2|Bacteria,2G7WN@200795|Chloroflexi	200795|Chloroflexi	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
SX2_k127_4083692_1	68219.JNXI01000010_gene5729	1.533e-65	232.0	COG0745@1|root,COG0745@2|Bacteria,2I8R2@201174|Actinobacteria	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
SX2_k127_4083692_0	158190.SpiGrapes_2634	9.43e-71	267.0	COG0642@1|root,COG2205@2|Bacteria,2J7ZP@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
SX2_k127_4083692_3	744872.Spica_0412	4.051e-16	81.0	2EMZY@1|root,33FN4@2|Bacteria,2J8Y2@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4083692_2	694431.DESACE_03340	4.02e-24	112.0	COG0778@1|root,COG0778@2|Bacteria,1RA6E@1224|Proteobacteria,42XB2@68525|delta/epsilon subdivisions,2WT59@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SX2_k127_4083692_5	478741.JAFS01000002_gene184	6.434e-06	55.0	2BFNX@1|root,329HD@2|Bacteria,46ZC6@74201|Verrucomicrobia,37GSZ@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4100543_12	243275.TDE_2696	0.0004827	43.0	COG3063@1|root,COG3063@2|Bacteria,2JBHH@203691|Spirochaetes	203691|Spirochaetes	NU	TPR domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4100543_0	1123274.KB899421_gene1771	6.788e-310	975.0	COG0782@1|root,COG1747@1|root,COG0782@2|Bacteria,COG1747@2|Bacteria,2J5MW@203691|Spirochaetes	203691|Spirochaetes	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	-	-	-	-	-	-	-	-	-	GreA_GreB,GreA_GreB_N
SX2_k127_4100543_6	573413.Spirs_2040	1.224e-42	180.0	COG2304@1|root,COG2304@2|Bacteria,2J67D@203691|Spirochaetes	203691|Spirochaetes	K	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
SX2_k127_4100543_8	889378.Spiaf_1529	6.811e-30	138.0	COG1413@1|root,COG1413@2|Bacteria,2J5WK@203691|Spirochaetes	203691|Spirochaetes	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
SX2_k127_4100543_2	1123274.KB899421_gene1768	1.142e-108	370.0	COG0728@1|root,COG0728@2|Bacteria,2J697@203691|Spirochaetes	203691|Spirochaetes	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
SX2_k127_4100543_10	85643.Tmz1t_2585	5.461e-19	97.0	COG0791@1|root,COG0791@2|Bacteria,1N0EE@1224|Proteobacteria,2VSHN@28216|Betaproteobacteria,2KWNA@206389|Rhodocyclales	206389|Rhodocyclales	M	NLP P60 protein	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60
SX2_k127_4100543_1	545694.TREPR_1715	7.204e-128	420.0	COG0343@1|root,COG0343@2|Bacteria,2J5U0@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
SX2_k127_4100543_5	443143.GM18_1183	2.337e-53	214.0	COG1940@1|root,COG1940@2|Bacteria,1MU94@1224|Proteobacteria,42RF4@68525|delta/epsilon subdivisions,2WPIV@28221|Deltaproteobacteria,43TWB@69541|Desulfuromonadales	28221|Deltaproteobacteria	GK	PFAM ROK family protein	glkA	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
SX2_k127_4100543_4	744872.Spica_1361	9.949e-75	268.0	COG0795@1|root,COG0795@2|Bacteria,2J64B@203691|Spirochaetes	203691|Spirochaetes	S	Permease, YjgP YjgQ family	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
SX2_k127_4100543_3	889378.Spiaf_1533	2.009e-83	293.0	COG0795@1|root,COG0795@2|Bacteria,2J5F9@203691|Spirochaetes	203691|Spirochaetes	S	Permease YjgP YjgQ family	-	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
SX2_k127_4100543_11	1268240.ATFI01000013_gene1112	4.882e-10	72.0	COG0642@1|root,COG0745@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,2FM2N@200643|Bacteroidia,4AMCC@815|Bacteroidaceae	976|Bacteroidetes	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
SX2_k127_4100543_7	906968.Trebr_1252	5.2e-42	168.0	COG0756@1|root,COG0756@2|Bacteria,2J7JH@203691|Spirochaetes	203691|Spirochaetes	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
SX2_k127_4100543_9	906968.Trebr_1964	3.92e-26	115.0	COG0612@1|root,COG0612@2|Bacteria,2J6UV@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the peptidase M16 family	pqqL	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
SX2_k127_4108578_1	1499967.BAYZ01000089_gene5014	8.581e-122	398.0	COG0043@1|root,COG0043@2|Bacteria	2|Bacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
SX2_k127_4108578_2	1499967.BAYZ01000089_gene5015	3.741e-91	320.0	COG1212@1|root,COG1212@2|Bacteria,2NP8R@2323|unclassified Bacteria	2|Bacteria	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
SX2_k127_4108578_5	1499967.BAYZ01000089_gene5019	4.337e-72	253.0	COG0329@1|root,COG0329@2|Bacteria,2NP5Q@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
SX2_k127_4108578_12	272562.CA_C0836	4.83e-25	116.0	COG2731@1|root,COG2731@2|Bacteria,1VCI9@1239|Firmicutes,24QNC@186801|Clostridia,36NJ1@31979|Clostridiaceae	186801|Clostridia	G	protein, YhcH YjgK YiaL family	-	-	-	-	-	-	-	-	-	-	-	-	DUF386
SX2_k127_4108578_14	1283283.ATXA01000006_gene1887	1.471e-12	79.0	COG0451@1|root,COG0451@2|Bacteria,2GP24@201174|Actinobacteria,4ESA0@85013|Frankiales	201174|Actinobacteria	GM	RmlD substrate binding domain	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
SX2_k127_4108578_11	326424.FRAAL6394	8.177e-29	127.0	COG0521@1|root,COG0521@2|Bacteria,2II28@201174|Actinobacteria,4ESU1@85013|Frankiales	201174|Actinobacteria	H	TIGRFAM molybdenum cofactor synthesis domain	mog	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoaE
SX2_k127_4108578_10	525282.HMPREF0391_10185	1.215e-42	169.0	COG0315@1|root,COG2258@1|root,COG0315@2|Bacteria,COG2258@2|Bacteria,1V3J4@1239|Firmicutes,24H9F@186801|Clostridia,22JGG@1570339|Peptoniphilaceae	186801|Clostridia	H	MoaC family	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
SX2_k127_4108578_9	266117.Rxyl_1981	4.812e-45	179.0	COG0315@1|root,COG0315@2|Bacteria,2IHR6@201174|Actinobacteria,4CSG6@84995|Rubrobacteria	84995|Rubrobacteria	H	MoaC family	-	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
SX2_k127_4108578_4	526224.Bmur_0323	4.256e-81	278.0	COG2896@1|root,COG2896@2|Bacteria,2J7IB@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
SX2_k127_4108578_7	1168034.FH5T_16915	2.291e-58	217.0	COG0303@1|root,COG0303@2|Bacteria,4NDYD@976|Bacteroidetes	976|Bacteroidetes	H	Molybdenum cofactor synthesis domain	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
SX2_k127_4108578_8	1499967.BAYZ01000161_gene394	3.957e-52	197.0	COG3842@1|root,COG3842@2|Bacteria	2|Bacteria	P	ATPase activity	gtsA	-	3.6.3.30,3.6.3.55	ko:K02010,ko:K02049,ko:K02068,ko:K02071,ko:K06857,ko:K10112	ko02010,map02010	M00186,M00188,M00190,M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00211,M00238,M00491,M00602,M00605,M00606	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1,3.A.1.10,3.A.1.16,3.A.1.17,3.A.1.24,3.A.1.6.2,3.A.1.6.4	-	-	ABC_tran,TOBE_2
SX2_k127_4108578_6	269799.Gmet_1040	2.032e-58	210.0	COG4662@1|root,COG4662@2|Bacteria,1MZVS@1224|Proteobacteria,42N6T@68525|delta/epsilon subdivisions,2WMKR@28221|Deltaproteobacteria,43S3K@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	tupB	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
SX2_k127_4108578_3	1125863.JAFN01000001_gene2036	2.367e-87	301.0	COG2998@1|root,COG2998@2|Bacteria,1MVSF@1224|Proteobacteria,42NK5@68525|delta/epsilon subdivisions,2WJ49@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	PBP superfamily domain	tupA	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
SX2_k127_4108578_13	1499967.BAYZ01000155_gene619	3.989e-16	90.0	2E1HF@1|root,32WVJ@2|Bacteria,2NRFV@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3996
SX2_k127_4108578_0	1499967.BAYZ01000032_gene1132	1.193e-257	818.0	COG4953@1|root,COG4953@2|Bacteria	2|Bacteria	M	penicillin binding	pbpC	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
SX2_k127_4111914_0	368408.Tpen_0002	3.559e-78	269.0	COG1363@1|root,arCOG01518@2157|Archaea,2XPWC@28889|Crenarchaeota	28889|Crenarchaeota	G	peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
SX2_k127_4111914_3	1307761.L21SP2_1266	1.215e-31	140.0	COG2176@1|root,COG2176@2|Bacteria,2JBJN@203691|Spirochaetes	203691|Spirochaetes	L	EXOIII	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
SX2_k127_4111914_2	1125863.JAFN01000001_gene3040	6.333e-39	158.0	COG0615@1|root,COG0615@2|Bacteria,1REW3@1224|Proteobacteria,42SGQ@68525|delta/epsilon subdivisions,2WPTP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	rfaE	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like
SX2_k127_4111914_1	374847.Kcr_1472	9.91e-52	208.0	COG0714@1|root,arCOG00441@2157|Archaea	2157|Archaea	V	ATPase associated with various cellular activities, AAA_5	gvpN	-	-	ko:K03924,ko:K04748	-	-	R00294	RC02794	ko00000,ko01000	3.D.4.10	-	-	AAA_5,CbbQ_C,HHH_5
SX2_k127_4111914_4	479434.Sthe_2858	5.625e-25	121.0	COG0714@1|root,COG2304@1|root,COG0714@2|Bacteria,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	ko:K03924,ko:K04748,ko:K07114	-	-	R00294	RC02794	ko00000,ko01000,ko02000	1.A.13.2.2,1.A.13.2.3,3.D.4.10	-	-	AAA_5,BatA,DUF4159,VIT,VWA_2,VWA_CoxE
SX2_k127_4111914_5	941449.dsx2_3002	8.677e-22	104.0	COG0778@1|root,COG0778@2|Bacteria,1RECN@1224|Proteobacteria,43DS9@68525|delta/epsilon subdivisions,2WNXD@28221|Deltaproteobacteria,2MGBW@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SX2_k127_414308_3	1469607.KK073768_gene3672	2.539e-89	313.0	COG1834@1|root,COG1915@1|root,COG1834@2|Bacteria,COG1915@2|Bacteria,1G2AU@1117|Cyanobacteria,1HK7P@1161|Nostocales	1117|Cyanobacteria	E	PFAM LOR SDH bifunctional enzyme conserved region	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf,Saccharop_dh_N
SX2_k127_414308_6	1198114.AciX9_1409	1.107e-18	100.0	COG1418@1|root,COG1418@2|Bacteria,3Y4NV@57723|Acidobacteria,2JJD3@204432|Acidobacteriia	204432|Acidobacteriia	S	mRNA catabolic process	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
SX2_k127_414308_1	448385.sce0767	7.452e-92	310.0	COG1305@1|root,COG1305@2|Bacteria,1R9WH@1224|Proteobacteria	1224|Proteobacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
SX2_k127_414308_5	446466.Cfla_0232	3.063e-37	155.0	COG4430@1|root,COG4430@2|Bacteria,2II0D@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
SX2_k127_414308_2	1232410.KI421416_gene2600	3.909e-90	314.0	COG4198@1|root,COG4198@2|Bacteria,1NPPY@1224|Proteobacteria,42NTB@68525|delta/epsilon subdivisions,2WKNX@28221|Deltaproteobacteria,43U98@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
SX2_k127_414308_4	665571.STHERM_c05610	4.357e-53	200.0	COG2199@1|root,COG3706@2|Bacteria,2J5A2@203691|Spirochaetes	203691|Spirochaetes	T	Diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
SX2_k127_414308_0	1123274.KB899407_gene229	1.196e-202	641.0	COG0077@1|root,COG2876@1|root,COG0077@2|Bacteria,COG2876@2|Bacteria,2J644@203691|Spirochaetes	203691|Spirochaetes	H	PFAM DAHP synthetase I KDSA	pheA	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,DAHP_synth_1,PDT
SX2_k127_4143551_1	545695.TREAZ_3659	1.897e-112	401.0	COG1452@1|root,COG1452@2|Bacteria,2J5EC@203691|Spirochaetes	203691|Spirochaetes	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4143551_2	573413.Spirs_2450	1.623e-106	356.0	COG1702@1|root,COG1702@2|Bacteria,2J64H@203691|Spirochaetes	203691|Spirochaetes	T	Phosphate starvation-inducible protein PhoH	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
SX2_k127_4143551_0	744872.Spica_1228	2.567e-131	447.0	COG1480@1|root,COG1480@2|Bacteria,2J5K4@203691|Spirochaetes	203691|Spirochaetes	S	7TM receptor with intracellular HD hydrolase	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
SX2_k127_4143551_3	545695.TREAZ_3662	5.155e-23	110.0	COG0319@1|root,COG0319@2|Bacteria,2J7YN@203691|Spirochaetes	203691|Spirochaetes	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
SX2_k127_4147855_12	1150621.SMUL_1050	2.433e-37	148.0	COG1335@1|root,COG1335@2|Bacteria,1MU5N@1224|Proteobacteria,42RN4@68525|delta/epsilon subdivisions,2YPXS@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
SX2_k127_4147855_7	1009370.ALO_04006	3.941e-74	260.0	COG0697@1|root,COG0697@2|Bacteria,1V1H0@1239|Firmicutes,4H40S@909932|Negativicutes	909932|Negativicutes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SX2_k127_4147855_10	484770.UFO1_3727	3.989e-45	175.0	COG0697@1|root,COG0697@2|Bacteria,1TRKE@1239|Firmicutes,4H5R7@909932|Negativicutes	909932|Negativicutes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SX2_k127_4147855_8	1519464.HY22_08455	2.046e-66	231.0	COG0225@1|root,COG0225@2|Bacteria,1FE4X@1090|Chlorobi	1090|Chlorobi	C	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
SX2_k127_4147855_1	10228.TriadP62141	3.356e-157	513.0	COG0405@1|root,KOG2410@2759|Eukaryota,38ENY@33154|Opisthokonta,3BN8F@33208|Metazoa	33208|Metazoa	E	Gamma-glutamyltranspeptidase 2-like	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
SX2_k127_4147855_3	1379698.RBG1_1C00001G1253	9.811e-103	356.0	COG1022@1|root,COG1022@2|Bacteria,2NNTM@2323|unclassified Bacteria	2|Bacteria	I	COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming)	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
SX2_k127_4147855_17	545243.BAEV01000038_gene1477	3.706e-07	59.0	2BS2G@1|root,32M38@2|Bacteria,1USYY@1239|Firmicutes,250ES@186801|Clostridia,36RJH@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4147855_15	251221.35213747	1.698e-17	91.0	COG0637@1|root,COG0637@2|Bacteria,1G0E4@1117|Cyanobacteria	1117|Cyanobacteria	S	TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED	-	-	3.1.3.18,5.4.2.6	ko:K01091,ko:K01838	ko00500,ko00630,ko01100,ko01110,ko01130,map00500,map00630,map01100,map01110,map01130	-	R01334,R02728,R11310	RC00017,RC00408	ko00000,ko00001,ko01000	-	-	-	HAD_2
SX2_k127_4147855_9	177437.HRM2_08770	4.856e-61	221.0	COG2199@1|root,COG3706@2|Bacteria,1N2X1@1224|Proteobacteria,42TUZ@68525|delta/epsilon subdivisions,2WQ1Q@28221|Deltaproteobacteria,2MKGE@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Carbohydrate-binding family 9	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_2
SX2_k127_4147855_16	907348.TresaDRAFT_0127	2.803e-13	79.0	2BRMP@1|root,32KM3@2|Bacteria,2J6W4@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Late competence development protein ComFB	-	-	-	ko:K02241	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	ComFB
SX2_k127_4147855_13	717231.Flexsi_2211	2.447e-32	136.0	COG1434@1|root,COG1434@2|Bacteria,2GFV3@200930|Deferribacteres	200930|Deferribacteres	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
SX2_k127_4147855_11	744872.Spica_2768	4.647e-44	173.0	COG0744@1|root,COG0744@2|Bacteria	2|Bacteria	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129,3.4.16.4	ko:K03814,ko:K05365,ko:K05366,ko:K21464	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
SX2_k127_4147855_6	941824.TCEL_01715	7.164e-79	276.0	COG0144@1|root,COG0144@2|Bacteria,1TPGQ@1239|Firmicutes,247N0@186801|Clostridia,36F0B@31979|Clostridiaceae	186801|Clostridia	J	NOL1 NOP2 sun family	rsmF	-	-	-	-	-	-	-	-	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,Methyltranf_PUA,RsmF_methylt_CI
SX2_k127_4147855_18	1121934.AUDX01000023_gene237	3.358e-05	55.0	COG0664@1|root,COG0664@2|Bacteria,2IKTT@201174|Actinobacteria,4FQ6G@85023|Microbacteriaceae	201174|Actinobacteria	T	helix_turn_helix, cAMP Regulatory protein	-	-	-	ko:K21562	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
SX2_k127_4147855_2	909663.KI867149_gene3381	4.617e-119	394.0	COG0116@1|root,COG0116@2|Bacteria,1MUQM@1224|Proteobacteria,42NJ1@68525|delta/epsilon subdivisions,2WJ5S@28221|Deltaproteobacteria,2MQHY@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Putative RNA methylase family UPF0020	rlmL	-	2.1.1.173,2.1.1.264	ko:K07444,ko:K12297	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,THUMP,UPF0020
SX2_k127_4147855_14	383372.Rcas_2295	1.799e-25	118.0	COG1196@1|root,COG1196@2|Bacteria,2G788@200795|Chloroflexi,376Y7@32061|Chloroflexia	32061|Chloroflexia	D	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
SX2_k127_4147855_0	1123274.KB899407_gene221	0.0	1234.0	COG0495@1|root,COG0495@2|Bacteria,2J5BV@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
SX2_k127_4147855_4	545694.TREPR_1107	8.714e-91	311.0	COG0006@1|root,COG0006@2|Bacteria,2J5QB@203691|Spirochaetes	203691|Spirochaetes	E	peptidase	-	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C
SX2_k127_4147855_5	1219084.AP014508_gene974	1.529e-88	302.0	COG1840@1|root,COG1840@2|Bacteria,2GCFT@200918|Thermotogae	200918|Thermotogae	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
SX2_k127_4150138_0	158190.SpiGrapes_0092	1.783e-138	447.0	COG1653@1|root,COG1653@2|Bacteria,2J70I@203691|Spirochaetes	203691|Spirochaetes	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_8
SX2_k127_4150138_2	158189.SpiBuddy_0246	1.116e-135	438.0	COG1175@1|root,COG1175@2|Bacteria,2J6WK@203691|Spirochaetes	203691|Spirochaetes	P	transporter	-	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
SX2_k127_4150138_4	158190.SpiGrapes_0090	5.428e-118	400.0	COG0395@1|root,COG0395@2|Bacteria,2J70J@203691|Spirochaetes	203691|Spirochaetes	P	ABC-type sugar transport system, permease component	-	-	-	ko:K10119,ko:K10202	ko02010,map02010	M00196,M00205	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.18,3.A.1.1.28	-	-	BPD_transp_1
SX2_k127_4150138_3	98439.AJLL01000025_gene203	1.098e-118	413.0	COG2942@1|root,COG2942@2|Bacteria,1G04P@1117|Cyanobacteria	1117|Cyanobacteria	G	PFAM N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)	-	-	5.1.3.8	ko:K01787	ko00520,map00520	-	R01207	RC00290	ko00000,ko00001,ko01000	-	-	-	GlcNAc_2-epim
SX2_k127_4150138_1	573413.Spirs_3218	2.156e-137	462.0	COG2103@1|root,COG2103@2|Bacteria	2|Bacteria	G	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate	-	-	4.2.1.126	ko:K07106	ko00520,ko01100,map00520,map01100	-	R08555	RC00397,RC00746	ko00000,ko00001,ko01000	-	-	-	-
SX2_k127_4150138_6	880071.Fleli_1291	1.669e-05	57.0	COG0385@1|root,COG0385@2|Bacteria,4NEDA@976|Bacteroidetes,47K7V@768503|Cytophagia	976|Bacteroidetes	S	SBF-like CPA transporter family (DUF4137)	-	-	-	ko:K14347	-	-	-	-	ko00000,ko02000,ko04147	2.A.93.1	-	-	SBF_like
SX2_k127_4150138_5	1410650.JHWL01000027_gene2268	2.807e-06	51.0	COG5426@1|root,COG5426@2|Bacteria,1TPH0@1239|Firmicutes,24892@186801|Clostridia,4BW80@830|Butyrivibrio	186801|Clostridia	S	Lacto-N-biose phosphorylase C-terminal domain	-	-	2.4.1.247	ko:K15534	-	-	-	-	ko00000,ko01000	-	-	-	LBP_C,LBP_M,Lact_bio_phlase
SX2_k127_4152936_0	573413.Spirs_2865	7.654e-81	277.0	COG0264@1|root,COG0264@2|Bacteria,2J58B@203691|Spirochaetes	203691|Spirochaetes	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
SX2_k127_4152936_1	1480694.DC28_00800	4.304e-78	266.0	COG0052@1|root,COG0052@2|Bacteria,2J5GZ@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
SX2_k127_4154968_7	573413.Spirs_0597	7.594e-30	119.0	COG2209@1|root,COG2209@2|Bacteria,2JA3V@203691|Spirochaetes	203691|Spirochaetes	C	Rnf-Nqr subunit, membrane protein	-	-	1.6.5.8	ko:K00350	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
SX2_k127_4154968_0	573413.Spirs_0598	7.214e-152	488.0	COG2871@1|root,COG2871@2|Bacteria,2JBKD@203691|Spirochaetes	203691|Spirochaetes	C	Oxidoreductase FAD-binding domain	-	-	1.6.5.8	ko:K00351	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
SX2_k127_4154968_5	1123274.KB899408_gene3930	1.005e-45	171.0	2B4IF@1|root,31XAC@2|Bacteria,2JAGS@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4154968_2	1195236.CTER_2031	9.604e-93	325.0	COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,24G9G@186801|Clostridia	186801|Clostridia	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
SX2_k127_4154968_4	1499967.BAYZ01000156_gene563	1.36e-68	250.0	COG1120@1|root,COG1120@2|Bacteria	2|Bacteria	HP	ATPase activity	fhuC	-	3.6.3.28,3.6.3.34	ko:K02013,ko:K02041	ko02010,map02010	M00223,M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14,3.A.1.9	-	-	ABC_tran
SX2_k127_4154968_1	697281.Mahau_2628	1.818e-108	368.0	COG0330@1|root,COG0330@2|Bacteria,1TPXU@1239|Firmicutes,248MP@186801|Clostridia,42F7F@68295|Thermoanaerobacterales	186801|Clostridia	O	SMART band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
SX2_k127_4154968_6	335543.Sfum_1206	2.879e-38	155.0	COG1051@1|root,COG1051@2|Bacteria,1QUM0@1224|Proteobacteria,42SY6@68525|delta/epsilon subdivisions,2WP3N@28221|Deltaproteobacteria,2MQJU@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
SX2_k127_4154968_3	335543.Sfum_0347	2.711e-75	265.0	COG0177@1|root,COG0177@2|Bacteria,1RAK3@1224|Proteobacteria,42M4V@68525|delta/epsilon subdivisions,2WPRX@28221|Deltaproteobacteria,2MQMZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Protein of unknown function (DUF2400)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2400
SX2_k127_4154968_8	1123274.KB899430_gene1682	2.345e-12	70.0	COG0525@1|root,COG0525@2|Bacteria,2J659@203691|Spirochaetes	203691|Spirochaetes	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
SX2_k127_4163028_0	1125863.JAFN01000001_gene393	1.767e-44	170.0	COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,42SBG@68525|delta/epsilon subdivisions,2WP66@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM AMMECR1 domain protein	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
SX2_k127_4163028_1	880073.Calab_1997	1.089e-31	130.0	COG1355@1|root,COG1355@2|Bacteria,2NQ00@2323|unclassified Bacteria	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,Memo
SX2_k127_4164205_11	744872.Spica_0422	5.703e-21	106.0	COG0457@1|root,COG0457@2|Bacteria,2J6MS@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_8
SX2_k127_4164205_10	203119.Cthe_1305	1.052e-33	137.0	COG0662@1|root,COG0662@2|Bacteria,1UI0P@1239|Firmicutes,24SCP@186801|Clostridia,3WQJK@541000|Ruminococcaceae	186801|Clostridia	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SX2_k127_4164205_4	1380394.JADL01000004_gene6037	4.462e-92	314.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,2TR0F@28211|Alphaproteobacteria,2JPYH@204441|Rhodospirillales	204441|Rhodospirillales	EH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
SX2_k127_4164205_6	1307761.L21SP2_0169	1.298e-79	273.0	COG0528@1|root,COG0528@2|Bacteria,2J5H9@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
SX2_k127_4164205_2	545695.TREAZ_2335	9.795e-95	321.0	COG1313@1|root,COG1313@2|Bacteria,2J68B@203691|Spirochaetes	203691|Spirochaetes	C	Radical SAM domain protein	pflX	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
SX2_k127_4164205_9	1123274.KB899407_gene237	2.328e-56	203.0	COG1259@1|root,COG1259@2|Bacteria,2J813@203691|Spirochaetes	203691|Spirochaetes	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase,UVR
SX2_k127_4164205_7	935948.KE386495_gene1239	2.999e-78	276.0	COG0407@1|root,COG0407@2|Bacteria,1UY51@1239|Firmicutes,24DZF@186801|Clostridia,42FW9@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX2_k127_4164205_12	1122915.AUGY01000009_gene4848	1.893e-08	64.0	COG0627@1|root,COG0627@2|Bacteria,1TPA9@1239|Firmicutes,4HD64@91061|Bacilli,26RX9@186822|Paenibacillaceae	91061|Bacilli	S	esterase	estA	-	-	ko:K03930	-	-	-	-	ko00000,ko01000	-	CE1	-	Esterase
SX2_k127_4164205_0	573413.Spirs_1293	9.982e-267	850.0	COG0466@1|root,COG0466@2|Bacteria,2J71Y@203691|Spirochaetes	203691|Spirochaetes	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon-2	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
SX2_k127_4164205_1	744872.Spica_1110	1.641e-190	602.0	COG1219@1|root,COG1219@2|Bacteria,2J5FF@203691|Spirochaetes	203691|Spirochaetes	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
SX2_k127_4164205_3	1123274.KB899417_gene2165	3.691e-92	318.0	COG0740@1|root,COG0740@2|Bacteria,2J5VY@203691|Spirochaetes	203691|Spirochaetes	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
SX2_k127_4164205_5	1480694.DC28_07030	3.549e-80	280.0	COG0544@1|root,COG0544@2|Bacteria,2J5FS@203691|Spirochaetes	203691|Spirochaetes	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
SX2_k127_4171654_1	796606.BMMGA3_06175	3.132e-44	164.0	COG2201@1|root,COG2201@2|Bacteria,1V3IU@1239|Firmicutes,4HGY2@91061|Bacilli,1ZG7Q@1386|Bacillus	91061|Bacilli	T	response regulator	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
SX2_k127_4171654_0	545694.TREPR_2208	1.492e-81	295.0	COG2604@1|root,COG2604@2|Bacteria,2J5P0@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF115	-	-	-	-	-	-	-	-	-	-	-	-	MAF_flag10
SX2_k127_4171654_2	665571.STHERM_c07450	9.41e-13	68.0	COG0768@1|root,COG0768@2|Bacteria,2J5D8@203691|Spirochaetes	203691|Spirochaetes	M	Cell division protein ftsI	pbp3	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
SX2_k127_4174588_3	926554.KI912652_gene4094	2.917e-50	182.0	COG0554@1|root,COG0554@2|Bacteria,1WI6Q@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	-	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
SX2_k127_4174588_0	1303518.CCALI_02464	2.051e-112	372.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX2_k127_4174588_1	1128421.JAGA01000002_gene377	9.564e-92	328.0	COG1063@1|root,COG1063@2|Bacteria,2NRAB@2323|unclassified Bacteria	2|Bacteria	E	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
SX2_k127_4174588_2	309803.CTN_0403	5.317e-91	319.0	COG3534@1|root,COG3534@2|Bacteria	2|Bacteria	G	alpha-L-arabinofuranosidase	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C,Glyco_hydro_79n
SX2_k127_4174588_4	720555.BATR1942_14230	3.618e-21	108.0	COG1653@1|root,COG1653@2|Bacteria,1UY14@1239|Firmicutes,4HEMF@91061|Bacilli,1ZQ33@1386|Bacillus	91061|Bacilli	G	COG1653 ABC-type sugar transport system, periplasmic component	yurO	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8
SX2_k127_4174588_5	1122132.AQYH01000001_gene927	3.043e-16	85.0	COG1175@1|root,COG1175@2|Bacteria,1NYFA@1224|Proteobacteria,2UT9K@28211|Alphaproteobacteria,4BJX1@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX2_k127_4179475_5	65497.JODV01000007_gene377	1.907e-16	87.0	COG0477@1|root,COG0477@2|Bacteria,2I2J7@201174|Actinobacteria,4E1M7@85010|Pseudonocardiales	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
SX2_k127_4179475_7	1227487.C474_17124	5.268e-13	82.0	COG1266@1|root,arCOG02766@2157|Archaea,2Y839@28890|Euryarchaeota,23X08@183963|Halobacteria	183963|Halobacteria	S	metal-dependent membrane protease	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
SX2_k127_4179475_10	463191.SSEG_05878	3.895e-07	63.0	COG5180@1|root,COG5180@2|Bacteria,2GKJ7@201174|Actinobacteria	201174|Actinobacteria	A	pathogenesis	-	-	-	-	-	-	-	-	-	-	-	-	GPDPase_memb
SX2_k127_4179475_3	665571.STHERM_c16550	2.064e-62	235.0	COG0451@1|root,COG0451@2|Bacteria,2J8I0@203691|Spirochaetes	203691|Spirochaetes	M	NAD(P)H-binding	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
SX2_k127_4179475_1	1121946.AUAX01000022_gene3840	9.273e-78	282.0	2DBF0@1|root,2Z8VT@2|Bacteria,2I88D@201174|Actinobacteria,4DIBF@85008|Micromonosporales	201174|Actinobacteria	S	3-oxo-5-alpha-steroid 4-dehydrogenase	-	-	1.3.1.22	ko:K12343	ko00140,map00140	-	R02208,R02497,R08954,R10242	RC00145	ko00000,ko00001,ko01000	-	-	-	Steroid_dh
SX2_k127_4179475_4	1278311.AUAL01000006_gene446	2.153e-38	160.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	iap	GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005623,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0036211,GO:0042597,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.11.10,3.4.11.24,3.4.11.6	ko:K09612,ko:K19701,ko:K19702	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M28
SX2_k127_4179475_0	744872.Spica_2563	3.328e-159	528.0	COG1032@1|root,COG1032@2|Bacteria,2J656@203691|Spirochaetes	203691|Spirochaetes	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4179475_8	1121918.ARWE01000001_gene3629	9.31e-10	71.0	COG1729@1|root,COG1729@2|Bacteria,1NE9U@1224|Proteobacteria,42W04@68525|delta/epsilon subdivisions,2WSHK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
SX2_k127_4179475_6	378806.STAUR_8075	8.463e-15	85.0	COG0457@1|root,COG0457@2|Bacteria,1QX6T@1224|Proteobacteria,43BZI@68525|delta/epsilon subdivisions,2X7AA@28221|Deltaproteobacteria,2YWVY@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4179475_9	338966.Ppro_1850	5.064e-09	68.0	COG0759@1|root,COG0759@2|Bacteria,1QA6X@1224|Proteobacteria,42VEQ@68525|delta/epsilon subdivisions,2WR96@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Haemolytic	-	-	-	-	-	-	-	-	-	-	-	-	Haemolytic
SX2_k127_4179475_11	761193.Runsl_2979	2.308e-05	56.0	2DQHQ@1|root,32UP5@2|Bacteria,4NU5I@976|Bacteroidetes,47MG3@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4179475_2	1047013.AQSP01000144_gene895	8.947e-69	239.0	COG2242@1|root,COG2242@2|Bacteria	2|Bacteria	H	protein methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
SX2_k127_4179601_2	1280706.AUJE01000026_gene1234	0.0001543	52.0	COG0810@1|root,COG0810@2|Bacteria,1VGV4@1239|Firmicutes,4H5RY@909932|Negativicutes	909932|Negativicutes	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
SX2_k127_4179601_0	1123274.KB899431_gene3266	4.284e-123	428.0	COG1196@1|root,COG1196@2|Bacteria,2J5RV@203691|Spirochaetes	203691|Spirochaetes	D	PFAM secretion protein HlyD family protein	-	-	-	-	-	-	-	-	-	-	-	-	Apolipoprotein,HTH_38
SX2_k127_4179601_1	203119.Cthe_1172	9.668e-27	116.0	COG1146@1|root,COG2006@1|root,COG1146@2|Bacteria,COG2006@2|Bacteria,1TRX2@1239|Firmicutes,249GX@186801|Clostridia,3WHJ8@541000|Ruminococcaceae	186801|Clostridia	C	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Fer4_10,Fer4_7
SX2_k127_4191686_1	889378.Spiaf_1081	3.322e-71	271.0	COG1624@1|root,COG1762@1|root,COG1624@2|Bacteria,COG1762@2|Bacteria,2J84N@203691|Spirochaetes	203691|Spirochaetes	G	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
SX2_k127_4191686_4	391735.Veis_4967	4.303e-06	59.0	COG0477@1|root,COG2814@2|Bacteria,1Q7KV@1224|Proteobacteria,2VZ2Y@28216|Betaproteobacteria	28216|Betaproteobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX2_k127_4191686_2	56780.SYN_02377	5.079e-28	119.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,42TN3@68525|delta/epsilon subdivisions,2WQ23@28221|Deltaproteobacteria,2MS9E@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
SX2_k127_4191686_0	665571.STHERM_c12610	1.064e-280	885.0	COG0542@1|root,COG0542@2|Bacteria,2J6BU@203691|Spirochaetes	203691|Spirochaetes	O	ATP-dependent Clp protease ATP-binding subunit ClpA	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
SX2_k127_4191686_3	42256.RradSPS_2513	3.051e-21	110.0	COG0477@1|root,COG2814@2|Bacteria,2I4BU@201174|Actinobacteria,4CTFA@84995|Rubrobacteria	84995|Rubrobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX2_k127_4191815_0	665571.STHERM_c09100	3.852e-202	645.0	COG1766@1|root,COG1766@2|Bacteria,2J5KB@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar M-ring protein	fliF	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
SX2_k127_4191815_1	744872.Spica_1669	2.164e-102	337.0	COG1536@1|root,COG1536@2|Bacteria,2J5CI@203691|Spirochaetes	203691|Spirochaetes	N	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliG	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
SX2_k127_4219966_5	1265505.ATUG01000002_gene2637	3.723e-82	276.0	29CZA@1|root,2ZZXB@2|Bacteria,1RFNE@1224|Proteobacteria,42TRV@68525|delta/epsilon subdivisions,2WR3X@28221|Deltaproteobacteria,2MKTT@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4219966_3	744872.Spica_2856	2.699e-87	296.0	COG4939@1|root,COG4939@2|Bacteria,2J7W0@203691|Spirochaetes	203691|Spirochaetes	S	FMN-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4219966_11	411473.RUMCAL_00402	7.504e-07	55.0	COG3780@1|root,COG3780@2|Bacteria	2|Bacteria	L	endonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4219966_6	665571.STHERM_c00450	4.674e-59	209.0	COG1366@1|root,COG1366@2|Bacteria,2J6J8@203691|Spirochaetes	203691|Spirochaetes	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	-	-	-	-	-	-	-	-	-	STAS
SX2_k127_4219966_8	1192034.CAP_5968	6.729e-24	107.0	COG4430@1|root,COG4430@2|Bacteria,1QZAG@1224|Proteobacteria	1224|Proteobacteria	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	DUF3052
SX2_k127_4219966_4	290318.Cvib_0786	7.609e-87	300.0	COG0454@1|root,COG0456@2|Bacteria,1FDE7@1090|Chlorobi	1090|Chlorobi	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4219966_9	658086.HMPREF0994_03474	4.32e-18	96.0	COG0407@1|root,COG0407@2|Bacteria,1UZSW@1239|Firmicutes,24E13@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX2_k127_4219966_1	326427.Cagg_1321	1.301e-115	415.0	COG1574@1|root,COG1574@2|Bacteria,2G5YJ@200795|Chloroflexi,375CQ@32061|Chloroflexia	32061|Chloroflexia	S	PFAM Amidohydrolase 3	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
SX2_k127_4219966_0	573413.Spirs_1197	9.734e-120	396.0	COG1846@1|root,COG1940@1|root,COG1846@2|Bacteria,COG1940@2|Bacteria,2J7X4@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator sugar kinase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,ROK
SX2_k127_4219966_2	744872.Spica_0059	1.473e-107	364.0	COG1653@1|root,COG1653@2|Bacteria,2J5WB@203691|Spirochaetes	203691|Spirochaetes	G	bacterial extracellular solute-binding protein	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_8
SX2_k127_4219966_7	158189.SpiBuddy_1771	8.734e-38	162.0	COG1175@1|root,COG1175@2|Bacteria,2J71Z@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
SX2_k127_4222277_3	8010.XP_010863284.1	4.458e-09	61.0	COG0446@1|root,KOG1336@2759|Eukaryota,38CNG@33154|Opisthokonta,3BH1J@33208|Metazoa,3CTAN@33213|Bilateria,4857Q@7711|Chordata,496S4@7742|Vertebrata,49S39@7898|Actinopterygii	33208|Metazoa	S	apoptosis-inducing factor	aifm3	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005783,GO:0006915,GO:0008150,GO:0008219,GO:0009987,GO:0012501,GO:0012505,GO:0016020,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0097194	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Reductase_C,Rieske
SX2_k127_4222277_2	926569.ANT_03650	1.697e-23	114.0	COG0671@1|root,COG0671@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	-	-	3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27	ko:K01096,ko:K19302	ko00550,ko00564,ko01100,map00550,map00564,map01100	-	R02029,R05627	RC00002,RC00017	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
SX2_k127_4222277_1	926569.ANT_03640	2.44e-54	200.0	COG0746@1|root,COG0746@2|Bacteria	2|Bacteria	H	molybdenum cofactor guanylyltransferase activity	mobA	GO:0003674,GO:0003824,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.77	ko:K03752,ko:K13818	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
SX2_k127_4222277_0	926569.ANT_03630	1.265e-87	298.0	COG5322@1|root,COG5322@2|Bacteria,2G8N0@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Shikimate quinate 5-dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Shikimate_DH
SX2_k127_4240804_4	868595.Desca_2486	1.556e-19	93.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,2604P@186807|Peptococcaceae	186801|Clostridia	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
SX2_k127_4240804_1	1449126.JQKL01000020_gene3332	2.509e-65	244.0	COG2055@1|root,COG2055@2|Bacteria,1TR0Z@1239|Firmicutes,247W5@186801|Clostridia	186801|Clostridia	C	Belongs to the LDH2 MDH2 oxidoreductase family	mdh	-	-	-	-	-	-	-	-	-	-	-	Ldh_2
SX2_k127_4240804_2	706587.Desti_3247	4.553e-60	215.0	COG0684@1|root,COG0684@2|Bacteria,1MW9P@1224|Proteobacteria,42VU3@68525|delta/epsilon subdivisions,2WRWJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Aldolase/RraA	-	-	4.1.3.17	ko:K10218	ko00362,ko00660,ko01120,map00362,map00660,map01120	-	R00008,R00350	RC00067,RC00502,RC01205	ko00000,ko00001,ko01000	-	-	-	RraA-like
SX2_k127_4240804_3	500633.CLOHIR_01617	1.927e-26	117.0	COG1802@1|root,COG1802@2|Bacteria,1TSV2@1239|Firmicutes,24C0U@186801|Clostridia,25QQ7@186804|Peptostreptococcaceae	186801|Clostridia	K	FCD	ydfH_4	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
SX2_k127_4240804_0	1210884.HG799478_gene15504	7.35e-70	255.0	COG0451@1|root,COG0451@2|Bacteria,2IYKN@203682|Planctomycetes	203682|Planctomycetes	M	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
SX2_k127_4240804_5	180332.JTGN01000003_gene1959	8.383e-05	51.0	COG0407@1|root,COG0407@2|Bacteria,1VJHK@1239|Firmicutes,24TV3@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX2_k127_424432_4	665571.STHERM_c08680	3.453e-05	46.0	COG0289@1|root,COG0289@2|Bacteria,2J647@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
SX2_k127_424432_0	665571.STHERM_c08670	6.365e-108	358.0	COG0329@1|root,COG0329@2|Bacteria,2J5J6@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
SX2_k127_424432_1	907348.TresaDRAFT_0382	4.053e-61	224.0	COG0030@1|root,COG0030@2|Bacteria,2J65T@203691|Spirochaetes	203691|Spirochaetes	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
SX2_k127_424432_3	665571.STHERM_c08650	1.201e-20	106.0	COG0658@1|root,COG0658@2|Bacteria	2|Bacteria	S	establishment of competence for transformation	comE	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
SX2_k127_424432_2	573413.Spirs_1506	4.547e-61	228.0	COG1413@1|root,COG1413@2|Bacteria,2J7D8@203691|Spirochaetes	203691|Spirochaetes	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4256313_2	926569.ANT_05540	2.375e-24	103.0	COG1363@1|root,COG1363@2|Bacteria,2G6EE@200795|Chloroflexi	200795|Chloroflexi	G	peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
SX2_k127_4256313_1	886293.Sinac_6174	9.22e-84	293.0	COG0598@1|root,COG0598@2|Bacteria,2IX61@203682|Planctomycetes	203682|Planctomycetes	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
SX2_k127_4256313_0	1459636.NTE_01726	7.618e-104	351.0	COG0192@1|root,arCOG07444@2157|Archaea,41S5P@651137|Thaumarchaeota	651137|Thaumarchaeota	H	S-adenosylmethionine synthetase	-	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
SX2_k127_4262264_0	497321.C664_02175	1.597e-178	571.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,2VJT0@28216|Betaproteobacteria,2KVAX@206389|Rhodocyclales	206389|Rhodocyclales	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	hoxH	-	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
SX2_k127_4262264_2	395965.Msil_2749	1.662e-65	240.0	COG1941@1|root,COG1941@2|Bacteria,1NS0E@1224|Proteobacteria,2TVJC@28211|Alphaproteobacteria,3NBT8@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	PFAM NADH ubiquinone oxidoreductase 20 kDa subunit	-	-	1.12.1.2	ko:K18007	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_q6
SX2_k127_4262264_1	395965.Msil_2750	2.132e-85	293.0	COG3383@1|root,COG3383@2|Bacteria,1MXTC@1224|Proteobacteria,2U6Y9@28211|Alphaproteobacteria,3NC3R@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	4Fe-4S single cluster domain	-	-	1.12.1.2	ko:K18006	-	-	-	-	ko00000,ko01000	-	-	-	Fer2_4,Fer4_15,NADH-G_4Fe-4S_3
SX2_k127_4262264_3	395965.Msil_2751	7.006e-28	115.0	COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,2TR1V@28211|Alphaproteobacteria,3NC06@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.12.1.2,1.6.5.3	ko:K00124,ko:K00335,ko:K18005	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
SX2_k127_4277302_1	370438.PTH_1344	2.014e-19	91.0	COG0324@1|root,COG0324@2|Bacteria,1TPSC@1239|Firmicutes,248HB@186801|Clostridia,260M1@186807|Peptococcaceae	186801|Clostridia	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
SX2_k127_4277302_3	945713.IALB_2216	1.386e-05	53.0	2EIUI@1|root,33CJV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4277302_2	1415779.JOMH01000001_gene1581	4.737e-06	57.0	COG2063@1|root,COG2063@2|Bacteria,1RDEY@1224|Proteobacteria,1S3XK@1236|Gammaproteobacteria,1X4EI@135614|Xanthomonadales	135614|Xanthomonadales	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgH	-	-	ko:K02393	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgH
SX2_k127_4277302_0	269799.Gmet_1934	1.37e-45	167.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,42M35@68525|delta/epsilon subdivisions,2WIX5@28221|Deltaproteobacteria,43UFS@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
SX2_k127_428973_10	67373.JOBF01000003_gene598	9.144e-31	132.0	COG1472@1|root,COG1472@2|Bacteria,2GM43@201174|Actinobacteria	201174|Actinobacteria	G	hydrolase, family 3	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3,Glyco_hydro_3_C
SX2_k127_428973_0	1499967.BAYZ01000022_gene223	3.171e-222	696.0	COG0006@1|root,COG0006@2|Bacteria,2NR73@2323|unclassified Bacteria	2|Bacteria	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
SX2_k127_428973_6	1499967.BAYZ01000022_gene221	6.713e-107	353.0	COG4166@1|root,COG4166@2|Bacteria	2|Bacteria	E	transmembrane transport	-	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
SX2_k127_428973_5	1499967.BAYZ01000022_gene221	1.386e-149	477.0	COG4166@1|root,COG4166@2|Bacteria	2|Bacteria	E	transmembrane transport	-	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
SX2_k127_428973_1	1499967.BAYZ01000022_gene224	2.048e-158	505.0	COG0601@1|root,COG0601@2|Bacteria,2NS0Q@2323|unclassified Bacteria	2|Bacteria	U	Binding-protein-dependent transport system inner membrane component	oppB	-	-	ko:K02033,ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
SX2_k127_428973_4	1499967.BAYZ01000022_gene225	2.461e-153	489.0	COG1173@1|root,COG1173@2|Bacteria	2|Bacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	oppC	-	-	ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
SX2_k127_428973_2	1499967.BAYZ01000022_gene226	1.595e-156	512.0	COG0444@1|root,COG0444@2|Bacteria	2|Bacteria	P	Belongs to the ABC transporter superfamily	oppD	-	-	ko:K02031,ko:K02032,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
SX2_k127_428973_3	1499967.BAYZ01000022_gene227	1.151e-154	503.0	COG4608@1|root,COG4608@2|Bacteria,2NP9Y@2323|unclassified Bacteria	2|Bacteria	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
SX2_k127_428973_7	941449.dsx2_1429	2.172e-88	304.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2M7UM@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
SX2_k127_428973_9	1123274.KB899422_gene107	9.224e-52	201.0	COG0565@1|root,COG0565@2|Bacteria,2J6NV@203691|Spirochaetes	203691|Spirochaetes	J	RNA methyltransferase TrmH family	trmJ	-	2.1.1.200	ko:K02533,ko:K15396	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
SX2_k127_428973_8	573413.Spirs_0140	9.314e-71	242.0	COG1366@1|root,COG1366@2|Bacteria,2J6J8@203691|Spirochaetes	203691|Spirochaetes	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	-	-	-	-	-	-	-	-	-	STAS
SX2_k127_4294203_34	665571.STHERM_c21760	1.089e-15	78.0	COG0072@1|root,COG0072@2|Bacteria,2J63Q@203691|Spirochaetes	203691|Spirochaetes	J	Phenylalanyl-tRNA synthetase, beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B5,tRNA-synt_2d,tRNA_bind
SX2_k127_4294203_20	744872.Spica_0155	2.729e-63	224.0	COG1839@1|root,COG1839@2|Bacteria,2JAAH@203691|Spirochaetes	203691|Spirochaetes	S	Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
SX2_k127_4294203_5	1047013.AQSP01000100_gene587	2.512e-134	439.0	COG2271@1|root,COG2271@2|Bacteria	2|Bacteria	G	transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX2_k127_4294203_29	744872.Spica_2772	5.825e-40	157.0	COG0071@1|root,COG0071@2|Bacteria,2J7MQ@203691|Spirochaetes	203691|Spirochaetes	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
SX2_k127_4294203_12	292459.STH2587	5.804e-89	317.0	COG1686@1|root,COG1686@2|Bacteria,1TQN0@1239|Firmicutes,249B3@186801|Clostridia	186801|Clostridia	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
SX2_k127_4294203_28	1499967.BAYZ01000041_gene2334	1.031e-41	169.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	VVA1313	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SX2_k127_4294203_30	765912.Thimo_1077	1.19e-36	145.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,1S3QR@1236|Gammaproteobacteria,1WYF7@135613|Chromatiales	135613|Chromatiales	O	Peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
SX2_k127_4294203_3	1230342.CTM_20481	1.94e-152	494.0	COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,36DT9@31979|Clostridiaceae	186801|Clostridia	V	Mate efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
SX2_k127_4294203_1	1089547.KB913013_gene977	1.381e-201	639.0	COG4225@1|root,COG4225@2|Bacteria,4NJYK@976|Bacteroidetes,47MFS@768503|Cytophagia	976|Bacteroidetes	S	Glycosyl Hydrolase Family 88	-	-	3.2.1.180	ko:K18581	-	-	R10867	RC00049,RC02427	ko00000,ko01000	-	GH88	-	Glyco_hydro_88
SX2_k127_4294203_22	234267.Acid_7125	8.123e-63	234.0	COG0662@1|root,COG0662@2|Bacteria,3Y6AM@57723|Acidobacteria	57723|Acidobacteria	G	Mannose-6-phosphate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SX2_k127_4294203_2	1121904.ARBP01000011_gene1473	1.935e-171	550.0	COG0673@1|root,COG0673@2|Bacteria,4NKJ1@976|Bacteroidetes,47JK9@768503|Cytophagia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX2_k127_4294203_14	1185876.BN8_03288	1.051e-83	304.0	COG1028@1|root,COG1028@2|Bacteria,4NHVK@976|Bacteroidetes,47K2F@768503|Cytophagia	976|Bacteroidetes	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
SX2_k127_4294203_18	1448389.BAVQ01000002_gene2863	4.946e-71	260.0	2DBMA@1|root,2Z9Y3@2|Bacteria,2I9ER@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
SX2_k127_4294203_33	526227.Mesil_2733	6.648e-17	85.0	COG0316@1|root,COG0316@2|Bacteria,1WKA9@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Belongs to the HesB IscA family	hesB	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
SX2_k127_4294203_13	404380.Gbem_0236	7.321e-85	294.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,42NCH@68525|delta/epsilon subdivisions,2WJDR@28221|Deltaproteobacteria,43TRH@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
SX2_k127_4294203_4	1125863.JAFN01000001_gene1250	6.199e-137	446.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MXG@68525|delta/epsilon subdivisions,2WJ6G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K11358	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
SX2_k127_4294203_10	357808.RoseRS_1256	7.225e-101	339.0	COG1108@1|root,COG1108@2|Bacteria,2G6GH@200795|Chloroflexi,376AB@32061|Chloroflexia	32061|Chloroflexia	P	ABC-3 protein	-	-	-	ko:K09819	-	M00243	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC-3
SX2_k127_4294203_19	383372.Rcas_1591	2.728e-67	246.0	COG0803@1|root,COG0803@2|Bacteria,2G8F6@200795|Chloroflexi,37738@32061|Chloroflexia	32061|Chloroflexia	P	Belongs to the bacterial solute-binding protein 9 family	-	-	-	ko:K02077,ko:K09818	-	M00243,M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ZnuA
SX2_k127_4294203_32	926569.ANT_20950	5.467e-20	102.0	COG0735@1|root,COG0735@2|Bacteria,2G74Y@200795|Chloroflexi	200795|Chloroflexi	P	Belongs to the Fur family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
SX2_k127_4294203_17	1229780.BN381_90106	1.64e-72	267.0	COG1968@1|root,COG1968@2|Bacteria,2GJVG@201174|Actinobacteria,3UWNR@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
SX2_k127_4294203_16	204669.Acid345_1550	3.4e-76	268.0	COG4307@1|root,COG4307@2|Bacteria,3Y69G@57723|Acidobacteria,2JM0B@204432|Acidobacteriia	204432|Acidobacteriia	S	Putative zinc-binding metallo-peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_Mx
SX2_k127_4294203_25	1191523.MROS_1522	2.134e-50	196.0	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlB1	-	6.3.2.4,6.3.5.5	ko:K01921,ko:K01955	ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502	M00051	R00256,R00575,R01150,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
SX2_k127_4294203_0	1116472.MGMO_21c00240	4.542e-210	670.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,1XEIR@135618|Methylococcales	135618|Methylococcales	H	Belongs to the citrate synthase family	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
SX2_k127_4294203_35	1319815.HMPREF0202_00724	2.087e-14	83.0	29IC7@1|root,3059E@2|Bacteria,37AAR@32066|Fusobacteria	32066|Fusobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4294203_31	1480694.DC28_13665	1.162e-24	109.0	2E5Q2@1|root,32M8Z@2|Bacteria,2J9FX@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4294203_21	1480694.DC28_13660	6.138e-63	231.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	fecI	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
SX2_k127_4294203_24	886293.Sinac_5809	2.135e-58	214.0	COG1028@1|root,COG1028@2|Bacteria,2J0Y9@203682|Planctomycetes	203682|Planctomycetes	IQ	Short chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SX2_k127_4294203_23	247490.KSU1_B0325	5.859e-61	220.0	COG0704@1|root,COG0704@2|Bacteria,2IYX4@203682|Planctomycetes	203682|Planctomycetes	P	Plays a role in the regulation of phosphate uptake	-	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
SX2_k127_4294203_8	335543.Sfum_0701	4.135e-105	346.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,42MWA@68525|delta/epsilon subdivisions,2WJEX@28221|Deltaproteobacteria,2MR99@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
SX2_k127_4294203_9	335543.Sfum_0702	4.949e-103	355.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,42NXP@68525|delta/epsilon subdivisions,2WK2A@28221|Deltaproteobacteria,2MRC2@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
SX2_k127_4294203_6	335543.Sfum_0703	2.842e-126	411.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,42MWK@68525|delta/epsilon subdivisions,2WJKH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	TIGRFAM phosphate ABC transporter, inner membrane subunit PstA	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
SX2_k127_4294203_7	335543.Sfum_0704	5.353e-122	413.0	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,42N2N@68525|delta/epsilon subdivisions,2WJJ1@28221|Deltaproteobacteria,2MQY5@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
SX2_k127_4294203_11	335543.Sfum_0705	2.76e-95	344.0	COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,42P0G@68525|delta/epsilon subdivisions,2WK7Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	TIGRFAM phosphate binding protein	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
SX2_k127_4294203_15	1499967.BAYZ01000074_gene2156	3.102e-78	271.0	COG2816@1|root,COG2816@2|Bacteria	2|Bacteria	L	NAD+ diphosphatase activity	nudC	-	1.3.7.1,3.6.1.22	ko:K03426,ko:K20449	ko00760,ko01100,ko01120,ko04146,map00760,map01100,map01120,map04146	-	R00103,R03004,R03164,R11104	RC00002,RC02422	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
SX2_k127_4294203_27	1304284.L21TH_0766	5.252e-44	172.0	COG3153@1|root,COG3153@2|Bacteria,1V3TY@1239|Firmicutes,25DB3@186801|Clostridia,36U94@31979|Clostridiaceae	186801|Clostridia	S	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SX2_k127_4325691_1	744872.Spica_1252	2.031e-36	153.0	COG2426@1|root,COG2426@2|Bacteria,2J7NY@203691|Spirochaetes	203691|Spirochaetes	S	small multi-drug export	-	-	-	-	-	-	-	-	-	-	-	-	Sm_multidrug_ex
SX2_k127_4325691_4	262724.TT_P0045	1.35e-06	60.0	COG0500@1|root,COG2226@2|Bacteria,1WJBF@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	Q	Methylase involved in ubiquinone menaquinone biosynthesis	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
SX2_k127_4325691_3	1463857.JOFZ01000012_gene1583	5.154e-28	130.0	2BVX8@1|root,30QZQ@2|Bacteria,2GZ2G@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4325691_0	498761.HM1_1613	1.268e-58	220.0	COG0546@1|root,COG0546@2|Bacteria,1V3YI@1239|Firmicutes,24CRF@186801|Clostridia	186801|Clostridia	C	Psort location Cytoplasmic, score	gph	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
SX2_k127_4325691_2	1382304.JNIL01000001_gene1514	1.043e-34	138.0	COG0251@1|root,COG0251@2|Bacteria,1V6HG@1239|Firmicutes,4HKEF@91061|Bacilli	91061|Bacilli	J	endoribonuclease L-PSP	yhaR	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
SX2_k127_433404_3	445972.ANACOL_02400	1.528e-79	272.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,24EXC@186801|Clostridia,3WMZM@541000|Ruminococcaceae	186801|Clostridia	E	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
SX2_k127_433404_2	357808.RoseRS_2056	3.433e-98	337.0	COG3875@1|root,COG3875@2|Bacteria,2G8B3@200795|Chloroflexi	200795|Chloroflexi	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
SX2_k127_433404_0	1121405.dsmv_3097	2.659e-218	709.0	COG0613@1|root,COG0613@2|Bacteria,1Q7I9@1224|Proteobacteria,42M1D@68525|delta/epsilon subdivisions,2WIMC@28221|Deltaproteobacteria,2MIFA@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_433404_1	1382359.JIAL01000001_gene240	1.835e-110	369.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
SX2_k127_433404_4	203124.Tery_2383	2.337e-56	220.0	COG0210@1|root,COG0457@1|root,COG0210@2|Bacteria,COG0457@2|Bacteria,1G4J0@1117|Cyanobacteria,1H968@1150|Oscillatoriales	1117|Cyanobacteria	L	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,TPR_1,TPR_11,TPR_2,TPR_8
SX2_k127_4343364_2	1307761.L21SP2_0314	5.727e-71	258.0	COG0577@1|root,COG0577@2|Bacteria,2J5MA@203691|Spirochaetes	203691|Spirochaetes	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
SX2_k127_4343364_0	1307761.L21SP2_0315	4.766e-93	322.0	COG4591@1|root,COG4591@2|Bacteria,2J6KF@203691|Spirochaetes	203691|Spirochaetes	M	ABC transporter permease	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX2_k127_4343364_3	1480694.DC28_06815	1.727e-54	200.0	COG2834@1|root,COG2834@2|Bacteria,2J5TZ@203691|Spirochaetes	203691|Spirochaetes	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
SX2_k127_4343364_4	243275.TDE_1848	2.478e-38	167.0	2DNEA@1|root,32X2Y@2|Bacteria,2J767@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4343364_1	1396418.BATQ01000146_gene3493	5.542e-78	278.0	COG1520@1|root,COG1520@2|Bacteria,46TV4@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
SX2_k127_4343364_5	357808.RoseRS_0888	5.768e-10	67.0	COG3822@1|root,COG3822@2|Bacteria	2|Bacteria	S	D-lyxose isomerase	-	-	5.3.1.15	ko:K09988	ko00040,map00040	-	R01898	RC00516	ko00000,ko00001,ko01000	-	-	-	Lyx_isomer
SX2_k127_4349493_1	1123274.KB899424_gene2967	1.347e-138	449.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,2J5WW@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Conserved region in glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4,GATase_2,GXGXG,Glu_syn_central,Glu_synthase
SX2_k127_4349493_0	880073.Calab_2883	4.939e-176	581.0	COG0493@1|root,COG0493@2|Bacteria,2NNUI@2323|unclassified Bacteria	2|Bacteria	E	Flavin containing amine oxidoreductase	gltD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	iJN678.gltD,iNJ661.Rv3858c,iSB619.SA_RS02450	Fer4_20,Pyr_redox_2
SX2_k127_4349493_2	330214.NIDE0660	1.064e-137	448.0	COG1373@1|root,COG1373@2|Bacteria,3J14P@40117|Nitrospirae	40117|Nitrospirae	S	AAA domain	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
SX2_k127_4349493_4	1122603.ATVI01000005_gene3439	5.622e-11	67.0	COG0286@1|root,COG0286@2|Bacteria,1MWUJ@1224|Proteobacteria,1RRRR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	helicase	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
SX2_k127_4349493_3	1173024.KI912149_gene5624	1.183e-12	79.0	COG1752@1|root,COG1752@2|Bacteria,1GKSA@1117|Cyanobacteria,1JMN6@1189|Stigonemataceae	1117|Cyanobacteria	S	Esterase of the alpha-beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4374405_0	665571.STHERM_c10030	1.932e-179	571.0	COG0519@1|root,COG0519@2|Bacteria,2J5C7@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	Asn_synthase,GATase,GMP_synt_C,NAD_synthase
SX2_k127_4378306_8	526218.Sterm_4009	5.015e-38	166.0	COG1172@1|root,COG1172@2|Bacteria	2|Bacteria	G	Belongs to the binding-protein-dependent transport system permease family	mglC	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944	-	ko:K10440,ko:K10541,ko:K17214	ko02010,map02010	M00212,M00214,M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.3	-	-	BPD_transp_2
SX2_k127_4378306_0	1380763.BG53_10715	2.384e-180	578.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,4H9VK@91061|Bacilli,26SVT@186822|Paenibacillaceae	91061|Bacilli	G	import. Responsible for energy coupling to the transport system	-	-	-	ko:K17215	ko02010,map02010	M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2	-	-	ABC_tran
SX2_k127_4378306_5	911045.PSE_p0066	6.748e-65	234.0	COG1879@1|root,COG1879@2|Bacteria,1MWGU@1224|Proteobacteria,2U2E3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	ABC-type sugar transport system periplasmic component	mocB1	-	-	ko:K10439,ko:K17213	ko02010,ko02030,map02010,map02030	M00212,M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
SX2_k127_4378306_1	545695.TREAZ_1902	2.93e-128	419.0	COG1181@1|root,COG1181@2|Bacteria,2J611@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
SX2_k127_4378306_4	1408473.JHXO01000011_gene2970	4.171e-67	239.0	COG0524@1|root,COG0524@2|Bacteria,4NGFK@976|Bacteroidetes,2FN72@200643|Bacteroidia	976|Bacteroidetes	G	Kinase, PfkB family	ydjH_1	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
SX2_k127_4378306_6	1278307.KB907015_gene3540	9.599e-64	236.0	COG2114@1|root,COG2114@2|Bacteria,1P8ZU@1224|Proteobacteria,1S6BW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_19
SX2_k127_4378306_9	575590.HMPREF0156_01212	2.916e-21	106.0	COG5563@1|root,COG5563@2|Bacteria,4NMV9@976|Bacteroidetes	976|Bacteroidetes	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,TIG
SX2_k127_4378306_3	1499967.BAYZ01000171_gene5560	3.577e-99	337.0	COG1148@1|root,COG1148@2|Bacteria	2|Bacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_oxidored,Fer4,Fer4_4,Fer4_6,Fer4_7,FlpD,NAD_binding_8,Pyr_redox_2
SX2_k127_4378306_7	1499967.BAYZ01000171_gene5560	2.502e-59	226.0	COG1148@1|root,COG1148@2|Bacteria	2|Bacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_oxidored,Fer4,Fer4_4,Fer4_6,Fer4_7,FlpD,NAD_binding_8,Pyr_redox_2
SX2_k127_4378306_11	1499967.BAYZ01000171_gene5561	2.162e-18	93.0	COG1908@1|root,COG1908@2|Bacteria	2|Bacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
SX2_k127_4378306_2	1499967.BAYZ01000171_gene5562	2.602e-103	339.0	COG4656@1|root,COG4656@2|Bacteria	2|Bacteria	C	electron transfer activity	rnfC	-	-	ko:K03615	-	-	-	-	ko00000	-	-	iHN637.CLJU_RS18525	Complex1_51K,Fer4_10,MTHFR_C,RnfC_N,SLBB
SX2_k127_4378306_10	589865.DaAHT2_0826	4.959e-20	102.0	COG0685@1|root,COG2069@1|root,COG0685@2|Bacteria,COG2069@2|Bacteria,1MXTZ@1224|Proteobacteria,42NTS@68525|delta/epsilon subdivisions,2WK04@28221|Deltaproteobacteria,2MIIA@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM Methylenetetrahydrofolate reductase	-	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD,MTHFR
SX2_k127_4379585_2	518766.Rmar_2408	8.557e-08	61.0	COG0745@1|root,COG2204@1|root,COG3852@1|root,COG0745@2|Bacteria,COG2204@2|Bacteria,COG3852@2|Bacteria,4PN2Z@976|Bacteroidetes	976|Bacteroidetes	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
SX2_k127_4379585_0	401526.TcarDRAFT_0871	7.042e-70	259.0	COG0642@1|root,COG2205@2|Bacteria,1TSQ1@1239|Firmicutes,4H2HG@909932|Negativicutes	909932|Negativicutes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HATPase_c,HisKA,PAS_4,Response_reg
SX2_k127_4379585_1	314230.DSM3645_09717	1.376e-15	79.0	COG2204@1|root,COG2204@2|Bacteria,2IYIG@203682|Planctomycetes	203682|Planctomycetes	T	CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
SX2_k127_4383530_2	158189.SpiBuddy_1586	2.301e-31	129.0	COG0664@1|root,COG0664@2|Bacteria,2J886@203691|Spirochaetes	203691|Spirochaetes	T	cyclic nucleotide-binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	cNMP_binding
SX2_k127_4383530_0	1094980.Mpsy_0389	5.17e-69	253.0	COG0053@1|root,arCOG01474@2157|Archaea,2XU96@28890|Euryarchaeota,2N9HJ@224756|Methanomicrobia	224756|Methanomicrobia	P	Dimerisation domain of Zinc Transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
SX2_k127_4383530_1	485913.Krac_12542	1.738e-41	163.0	COG1063@1|root,COG1063@2|Bacteria,2G7NV@200795|Chloroflexi	200795|Chloroflexi	C	Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
SX2_k127_4399128_19	240016.ABIZ01000001_gene1539	4.782e-25	114.0	COG1520@1|root,COG1520@2|Bacteria,46TV4@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
SX2_k127_4399128_14	446468.Ndas_3515	1.577e-55	214.0	COG0815@1|root,COG0815@2|Bacteria,2GP8X@201174|Actinobacteria,4EMQA@85012|Streptosporangiales	201174|Actinobacteria	M	Carbon-nitrogen hydrolase	-	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
SX2_k127_4399128_21	73044.JNXP01000034_gene3906	1.886e-11	75.0	COG0584@1|root,COG0584@2|Bacteria,2GM3M@201174|Actinobacteria	201174|Actinobacteria	C	glycerophosphoryl diester phosphodiesterase	glpQ1	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
SX2_k127_4399128_6	86416.Clopa_4635	4.09e-101	349.0	COG1177@1|root,COG1177@2|Bacteria,1URBC@1239|Firmicutes,24801@186801|Clostridia,36HQF@31979|Clostridiaceae	186801|Clostridia	P	inner membrane component	-	-	-	ko:K02053	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
SX2_k127_4399128_4	86416.Clopa_4634	6.451e-116	390.0	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,36EAA@31979|Clostridiaceae	186801|Clostridia	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
SX2_k127_4399128_7	86416.Clopa_4633	2.874e-99	346.0	COG4134@1|root,COG4134@2|Bacteria,1TR3G@1239|Firmicutes,24A5K@186801|Clostridia,36E1C@31979|Clostridiaceae	186801|Clostridia	S	Bacterial extracellular solute-binding protein	-	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_8
SX2_k127_4399128_10	1203606.HMPREF1526_01273	4.883e-82	286.0	COG1176@1|root,COG1176@2|Bacteria,1TR71@1239|Firmicutes,25C51@186801|Clostridia,36WPI@31979|Clostridiaceae	186801|Clostridia	U	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
SX2_k127_4399128_15	697281.Mahau_2253	9.816e-51	194.0	COG0407@1|root,COG0407@2|Bacteria,1V4YU@1239|Firmicutes,24FCZ@186801|Clostridia,42HY1@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
SX2_k127_4399128_0	658086.HMPREF0994_05396	2.885e-152	494.0	COG2211@1|root,COG2211@2|Bacteria	2|Bacteria	G	Major facilitator Superfamily	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX2_k127_4399128_17	1232410.KI421421_gene3684	7.535e-33	140.0	COG1181@1|root,COG1181@2|Bacteria,1MX3I@1224|Proteobacteria,42SA1@68525|delta/epsilon subdivisions,2WNIR@28221|Deltaproteobacteria,43UHD@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	ATP-grasp domain	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
SX2_k127_4399128_16	1499967.BAYZ01000104_gene3618	1.313e-48	190.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
SX2_k127_4399128_1	1291050.JAGE01000001_gene1799	5.492e-146	480.0	COG1653@1|root,COG1653@2|Bacteria,1UW8Q@1239|Firmicutes,25CTD@186801|Clostridia,3WNMN@541000|Ruminococcaceae	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_1,SBP_bac_8
SX2_k127_4399128_8	588581.Cpap_2223	6.206e-93	327.0	COG0395@1|root,COG0395@2|Bacteria,1TPHS@1239|Firmicutes,24AJG@186801|Clostridia,3WJNM@541000|Ruminococcaceae	186801|Clostridia	U	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
SX2_k127_4399128_2	755731.Clo1100_0143	1.414e-126	415.0	COG4209@1|root,COG4209@2|Bacteria,1TP33@1239|Firmicutes,248XU@186801|Clostridia,36HN2@31979|Clostridiaceae	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
SX2_k127_4399128_5	1499967.BAYZ01000027_gene1777	1.041e-102	364.0	COG5001@1|root,COG5001@2|Bacteria,2NP1A@2323|unclassified Bacteria	2|Bacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4084,EAL,GGDEF,MASE3,PAS
SX2_k127_4399128_11	1499967.BAYZ01000009_gene5388	1.024e-78	276.0	COG4130@1|root,COG4130@2|Bacteria	2|Bacteria	G	Xylose isomerase domain protein TIM barrel	iolI	-	5.3.99.11	ko:K06606	ko00562,ko01120,map00562,map01120	-	R09952	RC01513	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
SX2_k127_4399128_9	1499967.BAYZ01000019_gene6328	3.241e-90	307.0	COG1235@1|root,COG1235@2|Bacteria	2|Bacteria	P	May be involved in the transport of PQQ or its precursor to the periplasm	-	-	3.1.4.55	ko:K06167	ko00440,map00440	-	R10205	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
SX2_k127_4399128_12	1356854.N007_16385	3.995e-68	241.0	COG1082@1|root,COG1082@2|Bacteria,1UYRD@1239|Firmicutes,4HEHD@91061|Bacilli	91061|Bacilli	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SX2_k127_4399128_3	661478.OP10G_3489	3.636e-118	392.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX2_k127_4399128_13	1122921.KB898187_gene4651	5.259e-67	237.0	COG1082@1|root,COG1082@2|Bacteria,1TSK3@1239|Firmicutes,4HCGV@91061|Bacilli,26QPM@186822|Paenibacillaceae	91061|Bacilli	G	Xylose isomerase	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SX2_k127_4399128_18	33035.JPJF01000051_gene786	1.734e-26	120.0	COG3622@1|root,COG3622@2|Bacteria,1V3V8@1239|Firmicutes,25C7T@186801|Clostridia	186801|Clostridia	G	Belongs to the hyi family	-	-	5.3.1.22	ko:K01816	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
SX2_k127_442871_0	1123376.AUIU01000012_gene1396	2.429e-85	303.0	COG1074@1|root,COG1074@2|Bacteria,3J16M@40117|Nitrospirae	40117|Nitrospirae	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
SX2_k127_4444787_4	573413.Spirs_3904	1.416e-69	254.0	2CAZD@1|root,342TQ@2|Bacteria,2J9GV@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4444787_7	665571.STHERM_c02890	4.879e-38	159.0	2AMN9@1|root,33WHF@2|Bacteria,2J7R4@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4444787_2	665571.STHERM_c02880	3.397e-85	302.0	2CB4X@1|root,33R8E@2|Bacteria,2J66H@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4444787_3	573413.Spirs_3906	9.746e-85	301.0	2F1P1@1|root,33UPB@2|Bacteria,2J896@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4444787_1	706587.Desti_3108	9.352e-130	428.0	COG3635@1|root,COG3635@2|Bacteria,1R4TM@1224|Proteobacteria,43DQP@68525|delta/epsilon subdivisions,2X6VW@28221|Deltaproteobacteria,2MR1H@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	2,3-bisphosphoglycerate-independent phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
SX2_k127_4444787_6	1499967.BAYZ01000088_gene5106	4.954e-41	158.0	COG0095@1|root,COG0095@2|Bacteria	2|Bacteria	H	Lipoate-protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
SX2_k127_4444787_5	1123274.KB899418_gene2367	4.031e-55	220.0	2E9WN@1|root,3342D@2|Bacteria,2J71N@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4444787_0	545695.TREAZ_1519	0.0	1247.0	COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,2J5M3@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC,Ribonuc_red_lgN
SX2_k127_447901_4	661478.OP10G_0618	5.797e-70	246.0	COG2242@1|root,COG2242@2|Bacteria	2|Bacteria	H	protein methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
SX2_k127_447901_7	1235835.C814_02336	1.985e-41	173.0	COG1368@1|root,COG1368@2|Bacteria,1V8EX@1239|Firmicutes,24KF8@186801|Clostridia,3WMJ8@541000|Ruminococcaceae	186801|Clostridia	M	CytoplasmicMembrane, score 9.99	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
SX2_k127_447901_6	744872.Spica_2052	1.212e-45	185.0	COG2095@1|root,COG2095@2|Bacteria,2J7MT@203691|Spirochaetes	203691|Spirochaetes	U	membrane	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
SX2_k127_447901_1	448385.sce3847	1.281e-108	380.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,42MKY@68525|delta/epsilon subdivisions,2WM9K@28221|Deltaproteobacteria,2YV33@29|Myxococcales	28221|Deltaproteobacteria	E	Threonine dehydratase	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SX2_k127_447901_2	59374.Fisuc_1504	1.171e-103	366.0	COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria	2|Bacteria	E	Belongs to the acetyltransferase family. ArgA subfamily	argA	GO:0003674,GO:0003824,GO:0003991,GO:0004042,GO:0004358,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016407,GO:0016410,GO:0016597,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.7.2.8	ko:K00619,ko:K00930,ko:K14682	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02649	RC00002,RC00004,RC00043,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	iECP_1309.ECP_2830,iLF82_1304.LF82_0116,iNRG857_1313.NRG857_13920,iYL1228.KPN_03226	AA_kinase,Acetyltransf_1
SX2_k127_447901_3	240016.ABIZ01000001_gene4263	2.104e-99	350.0	COG2013@1|root,COG2013@2|Bacteria,46SY6@74201|Verrucomicrobia,2IVCN@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
SX2_k127_447901_8	1123274.KB899409_gene539	5.161e-33	141.0	COG1652@1|root,COG1652@2|Bacteria,2J7QX@203691|Spirochaetes	203691|Spirochaetes	S	Treponemal membrane protein	tmpB	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	LysM
SX2_k127_447901_0	926569.ANT_28640	0.0	1190.0	COG3459@1|root,COG3459@2|Bacteria	2|Bacteria	G	carbohydrate binding	cbpA	-	2.4.1.20	ko:K00702	ko00500,ko01100,map00500,map01100	-	R00952	RC00049	ko00000,ko00001,ko01000	-	GT36	-	Glyco_hydro_36,Glyco_transf_36
SX2_k127_447901_5	760011.Spico_0894	1.945e-53	190.0	COG0395@1|root,COG0395@2|Bacteria,2J5WH@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
SX2_k127_4485035_1	573413.Spirs_2249	1.409e-130	427.0	COG1593@1|root,COG3090@1|root,COG1593@2|Bacteria,COG3090@2|Bacteria,2J5NW@203691|Spirochaetes	203691|Spirochaetes	G	transporter, DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
SX2_k127_4485035_2	1033810.HLPCO_001911	1.58e-49	190.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SX2_k127_4485035_5	1536774.H70357_19225	1.163e-16	89.0	2DP2A@1|root,33085@2|Bacteria,1VFZM@1239|Firmicutes,4I7GQ@91061|Bacilli,26WS6@186822|Paenibacillaceae	91061|Bacilli	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
SX2_k127_4485035_0	665571.STHERM_c01070	5.08e-153	512.0	COG2114@1|root,COG2114@2|Bacteria,2J6Q9@203691|Spirochaetes	203691|Spirochaetes	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP,Response_reg
SX2_k127_4485035_4	665571.STHERM_c01120	1.074e-26	127.0	2C0A1@1|root,33WBM@2|Bacteria,2J8WC@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4485035_3	247490.KSU1_C0730	1.272e-42	179.0	COG2234@1|root,COG3291@1|root,COG3420@1|root,COG4409@1|root,COG5184@1|root,COG5276@1|root,COG2234@2|Bacteria,COG3291@2|Bacteria,COG3420@2|Bacteria,COG4409@2|Bacteria,COG5184@2|Bacteria,COG5276@2|Bacteria	2|Bacteria	DZ	guanyl-nucleotide exchange factor activity	iap	GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005623,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0036211,GO:0042597,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.2.1.4,3.4.11.10,3.4.11.24,3.4.11.6	ko:K01179,ko:K03929,ko:K09612,ko:K12287,ko:K19701,ko:K19702	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000,ko01002,ko02044	-	CE10,GH5,GH9	-	Beta_helix,Peptidase_M28
SX2_k127_4485035_6	1500893.JQNB01000001_gene1536	7.709e-11	76.0	COG4625@1|root,COG4625@2|Bacteria,1QU2X@1224|Proteobacteria,1SG73@1236|Gammaproteobacteria,1X5NU@135614|Xanthomonadales	135614|Xanthomonadales	M	Autotransporter beta-domain	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Calx-beta,He_PIG
SX2_k127_4493097_3	744872.Spica_1119	5.261e-13	77.0	COG2206@1|root,COG2206@2|Bacteria,2J588@203691|Spirochaetes	203691|Spirochaetes	T	HD domain protein	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5
SX2_k127_4493097_0	1123274.KB899419_gene1884	1.005e-36	147.0	COG1214@1|root,COG1214@2|Bacteria,2J80U@203691|Spirochaetes	203691|Spirochaetes	O	Universal bacterial protein YeaZ	yeaZ	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
SX2_k127_4493097_1	552811.Dehly_1127	2.368e-29	123.0	COG0802@1|root,COG0802@2|Bacteria,2G6YV@200795|Chloroflexi,34CZN@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	-	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
SX2_k127_4493097_2	545694.TREPR_3483	5.007e-19	101.0	COG5581@1|root,COG5581@2|Bacteria,2J6AM@203691|Spirochaetes	203691|Spirochaetes	M	Type IV pilus assembly	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
SX2_k127_4493097_4	744872.Spica_1124	6.138e-11	68.0	2FFSV@1|root,347Q1@2|Bacteria,2J89P@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4508962_3	403833.Pmob_1331	4.025e-113	369.0	COG1173@1|root,COG1173@2|Bacteria,2GE0Y@200918|Thermotogae	200918|Thermotogae	U	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
SX2_k127_4508962_0	660470.Theba_2418	1.934e-151	484.0	COG0444@1|root,COG0444@2|Bacteria,2GDWH@200918|Thermotogae	200918|Thermotogae	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
SX2_k127_4508962_1	660470.Theba_2419	5.312e-151	489.0	COG4608@1|root,COG4608@2|Bacteria,2GC91@200918|Thermotogae	200918|Thermotogae	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
SX2_k127_4508962_11	331678.Cphamn1_1480	3.579e-05	57.0	2CIUH@1|root,32S8I@2|Bacteria,1FFDK@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4508962_2	383372.Rcas_3626	9.719e-134	438.0	COG0477@1|root,COG0477@2|Bacteria,2GA6R@200795|Chloroflexi,3782R@32061|Chloroflexia	32061|Chloroflexia	EGP	major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
SX2_k127_4508962_7	697281.Mahau_2229	1.123e-55	208.0	COG1592@1|root,COG4802@1|root,COG1592@2|Bacteria,COG4802@2|Bacteria,1VXAD@1239|Firmicutes,251K3@186801|Clostridia,42IFQ@68295|Thermoanaerobacterales	186801|Clostridia	C	Ferredoxin thioredoxin reductase catalytic beta chain	-	-	-	-	-	-	-	-	-	-	-	-	FeThRed_B
SX2_k127_4508962_9	456442.Mboo_0832	5.924e-21	105.0	COG0695@1|root,arCOG02606@2157|Archaea	2157|Archaea	O	PFAM Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
SX2_k127_4508962_5	1111479.AXAR01000001_gene311	1.167e-64	232.0	COG5482@1|root,COG5482@2|Bacteria,1V3FI@1239|Firmicutes,4HI6C@91061|Bacilli	91061|Bacilli	S	Putative PD-(D/E)XK phosphodiesterase (DUF2161)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2161
SX2_k127_4508962_4	1304880.JAGB01000001_gene547	1.405e-105	356.0	COG0454@1|root,COG0456@2|Bacteria,1TT30@1239|Firmicutes,24DE0@186801|Clostridia	186801|Clostridia	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SX2_k127_4508962_8	1121422.AUMW01000012_gene2918	2.689e-27	128.0	COG0388@1|root,COG0388@2|Bacteria,1TQDK@1239|Firmicutes,24AWV@186801|Clostridia	186801|Clostridia	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
SX2_k127_4508962_6	1047013.AQSP01000140_gene2513	6.338e-61	224.0	COG1322@1|root,COG1322@2|Bacteria,2NPXU@2323|unclassified Bacteria	2|Bacteria	S	RmuC family	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
SX2_k127_4508962_10	1286171.EAL2_c19310	9.771e-14	82.0	COG1633@1|root,COG1633@2|Bacteria,1VAXV@1239|Firmicutes,24KX7@186801|Clostridia	186801|Clostridia	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2202
SX2_k127_4510447_0	1125700.HMPREF9195_02075	6.34e-115	378.0	COG0187@1|root,COG0187@2|Bacteria,2J6PT@203691|Spirochaetes	203691|Spirochaetes	L	DNA topoisomerase	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
SX2_k127_4510447_4	278957.ABEA03000091_gene678	2.071e-34	146.0	COG0673@1|root,COG0673@2|Bacteria,46YAS@74201|Verrucomicrobia,3K98D@414999|Opitutae	414999|Opitutae	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX2_k127_4510447_3	1125863.JAFN01000001_gene917	3.843e-40	162.0	COG1082@1|root,COG1082@2|Bacteria,1Q8EI@1224|Proteobacteria,430TI@68525|delta/epsilon subdivisions,2WVQ8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SX2_k127_4510447_2	483215.BACFIN_05060	4.524e-55	223.0	COG3250@1|root,COG3250@2|Bacteria,4NGNR@976|Bacteroidetes,2FPKM@200643|Bacteroidia,4APBU@815|Bacteroidaceae	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 2 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
SX2_k127_4510447_1	1536770.R50345_02155	3.744e-68	253.0	COG1653@1|root,COG1653@2|Bacteria,1V3DA@1239|Firmicutes,4I7R9@91061|Bacilli,26X83@186822|Paenibacillaceae	91061|Bacilli	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_8
SX2_k127_4510447_5	632292.Calhy_0194	7.779e-12	66.0	COG0395@1|root,COG0395@2|Bacteria,1TQ9F@1239|Firmicutes,249DD@186801|Clostridia,42FYV@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K17320	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
SX2_k127_4517623_0	945713.IALB_0532	1.153e-127	424.0	COG1145@1|root,COG4191@1|root,COG4624@1|root,COG1145@2|Bacteria,COG4191@2|Bacteria,COG4624@2|Bacteria	2|Bacteria	C	iron-sulfur cluster assembly	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	FeS,Fe_hyd_lg_C,Fer4,Fer4_10,Fer4_7,HATPase_c,HTH_8,PAS,PAS_8,Sigma54_activat
SX2_k127_4518725_1	573.JG24_23355	2.684e-47	180.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,1S3PD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015075,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
SX2_k127_4518725_2	1122138.AQUZ01000012_gene6041	6.929e-42	175.0	2C1EG@1|root,2Z7MZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4518725_0	530564.Psta_1627	1.025e-73	261.0	COG5316@1|root,COG5316@2|Bacteria,2IY3B@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
SX2_k127_4548131_0	1038862.KB893840_gene1188	2.624e-79	274.0	COG0673@1|root,COG0673@2|Bacteria,1MUP0@1224|Proteobacteria,2TT57@28211|Alphaproteobacteria,3JSAU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX2_k127_4548131_3	395961.Cyan7425_1474	1.371e-43	179.0	COG0757@1|root,COG0757@2|Bacteria,1G5X4@1117|Cyanobacteria,3KI19@43988|Cyanothece	1117|Cyanobacteria	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
SX2_k127_4548131_2	663278.Ethha_0219	3.932e-45	172.0	COG0757@1|root,COG0757@2|Bacteria,1V6E8@1239|Firmicutes,24JBK@186801|Clostridia,3WIYS@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
SX2_k127_4548131_4	264198.Reut_A1423	0.00021	52.0	COG3622@1|root,COG3622@2|Bacteria,1MV53@1224|Proteobacteria,2VJ19@28216|Betaproteobacteria,1K048@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Belongs to the hyi family	hyi2	-	5.3.1.22,5.3.1.35	ko:K01816,ko:K22131	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
SX2_k127_4548131_1	935948.KE386494_gene473	1.878e-70	244.0	COG0476@1|root,COG0476@2|Bacteria,1TQ3U@1239|Firmicutes,25CJC@186801|Clostridia,42F84@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM UBA THIF-type NAD FAD binding	moeB	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
SX2_k127_4551924_1	1168034.FH5T_01550	7.257e-94	327.0	COG1520@1|root,COG1520@2|Bacteria,4P1VG@976|Bacteroidetes,2FW8D@200643|Bacteroidia	976|Bacteroidetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
SX2_k127_4551924_0	351627.Csac_0620	2.571e-181	596.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,42I0X@68295|Thermoanaerobacterales	186801|Clostridia	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	nuoF2	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,Fer4_20,NADH_4Fe-4S,Pyr_redox_2,SLBB
SX2_k127_4551924_2	1168034.FH5T_01535	4.569e-89	312.0	COG0493@1|root,COG0493@2|Bacteria,4P2CU@976|Bacteroidetes,2FXPN@200643|Bacteroidia	976|Bacteroidetes	E	2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4,Fer4_20
SX2_k127_4551924_3	1168034.FH5T_01530	5.13e-56	222.0	COG1520@1|root,COG1520@2|Bacteria,4P310@976|Bacteroidetes	976|Bacteroidetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_3
SX2_k127_4551924_4	497964.CfE428DRAFT_4944	2.408e-46	173.0	COG1136@1|root,COG1136@2|Bacteria,46V6W@74201|Verrucomicrobia	74201|Verrucomicrobia	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
SX2_k127_45559_3	665571.STHERM_c09080	1.133e-46	174.0	COG1558@1|root,COG1558@2|Bacteria,2J7Q7@203691|Spirochaetes	203691|Spirochaetes	N	Belongs to the flagella basal body rod proteins family	flgC	-	-	ko:K02388	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
SX2_k127_45559_2	665571.STHERM_c09070	1.755e-47	174.0	COG1815@1|root,COG1815@2|Bacteria,2J804@203691|Spirochaetes	203691|Spirochaetes	N	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body	flgB	-	-	ko:K02387	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod
SX2_k127_45559_0	665571.STHERM_c09060	3.77e-184	595.0	COG1220@1|root,COG1220@2|Bacteria,2J68E@203691|Spirochaetes	203691|Spirochaetes	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
SX2_k127_45559_1	573413.Spirs_1557	4.653e-72	251.0	COG5405@1|root,COG5405@2|Bacteria,2J608@203691|Spirochaetes	203691|Spirochaetes	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
SX2_k127_45559_4	247490.KSU1_C0574	2.569e-29	118.0	COG4974@1|root,COG4974@2|Bacteria,2IX6A@203682|Planctomycetes	203682|Planctomycetes	D	Belongs to the 'phage' integrase family. XerC subfamily	-	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
SX2_k127_4558061_3	338966.Ppro_2626	9.399e-136	447.0	COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,42PV5@68525|delta/epsilon subdivisions,2WIKH@28221|Deltaproteobacteria,43UC2@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	PFAM multi antimicrobial extrusion protein MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
SX2_k127_4558061_9	1463903.JOIZ01000016_gene632	3.437e-49	189.0	COG1609@1|root,COG1609@2|Bacteria,2GJRG@201174|Actinobacteria	201174|Actinobacteria	K	Periplasmic binding protein LacI transcriptional regulator	bxlR	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
SX2_k127_4558061_0	1499967.BAYZ01000131_gene337	2.137e-176	561.0	COG0399@1|root,COG0399@2|Bacteria,2NQH7@2323|unclassified Bacteria	2|Bacteria	E	Cys/Met metabolism PLP-dependent enzyme	stsA	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0016051,GO:0043170,GO:0044238,GO:0071704,GO:1901576	2.6.1.109	ko:K19715	-	-	R11395	RC00160	ko00000,ko01000,ko01005	-	-	-	DegT_DnrJ_EryC1
SX2_k127_4558061_14	1268072.PSAB_05425	1.561e-17	87.0	COG3976@1|root,COG3976@2|Bacteria,1VFG0@1239|Firmicutes,4HZ4C@91061|Bacilli,2760P@186822|Paenibacillaceae	91061|Bacilli	S	FMN_bind	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind
SX2_k127_4558061_13	1150398.JIBJ01000012_gene2070	4.03e-21	107.0	COG3832@1|root,COG3832@2|Bacteria,2GY9A@201174|Actinobacteria	201174|Actinobacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4558061_17	883.DvMF_2990	2.648e-10	72.0	COG2020@1|root,COG2020@2|Bacteria,1PK5Y@1224|Proteobacteria,43E9G@68525|delta/epsilon subdivisions,2WZHZ@28221|Deltaproteobacteria,2MDZJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
SX2_k127_4558061_12	404589.Anae109_1645	1.041e-23	111.0	COG3427@1|root,COG3427@2|Bacteria,1PB5Q@1224|Proteobacteria	1224|Proteobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
SX2_k127_4558061_1	1499967.BAYZ01000152_gene1409	5.28e-166	529.0	COG4134@1|root,COG4134@2|Bacteria	2|Bacteria	S	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
SX2_k127_4558061_6	1499967.BAYZ01000152_gene1408	4.042e-105	362.0	COG1176@1|root,COG1176@2|Bacteria	2|Bacteria	P	putrescine transport	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
SX2_k127_4558061_5	1499967.BAYZ01000152_gene1407	8.284e-114	372.0	COG1177@1|root,COG1177@2|Bacteria	2|Bacteria	P	DNA import into cell involved in transformation	-	-	-	ko:K02053	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
SX2_k127_4558061_4	1499967.BAYZ01000152_gene1406	1.159e-124	416.0	COG3842@1|root,COG3842@2|Bacteria	2|Bacteria	P	ATPase activity	-	-	3.6.3.30	ko:K02010,ko:K02052	ko02010,ko02024,map02010,map02024	M00190,M00193	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10,3.A.1.11	-	-	ABC_tran,TOBE_2
SX2_k127_4558061_15	324602.Caur_3231	4.038e-17	91.0	COG1234@1|root,COG1234@2|Bacteria,2G6YW@200795|Chloroflexi,376Z6@32061|Chloroflexia	32061|Chloroflexia	S	PFAM beta-lactamase domain protein	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
SX2_k127_4558061_8	1157632.AQWQ01000001_gene5519	2.754e-53	209.0	COG1609@1|root,COG1609@2|Bacteria,2GJV7@201174|Actinobacteria	201174|Actinobacteria	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
SX2_k127_4558061_16	596324.TREVI0001_0622	8.809e-14	74.0	COG4456@1|root,COG4456@2|Bacteria,2J962@203691|Spirochaetes	203691|Spirochaetes	S	Antidote-toxin recognition MazE, bacterial antitoxin	-	-	-	ko:K18829	-	-	-	-	ko00000,ko02048	-	-	-	MazE_antitoxin
SX2_k127_4558061_10	56110.Oscil6304_5834	3.721e-36	145.0	COG1487@1|root,COG1487@2|Bacteria,1G69D@1117|Cyanobacteria,1HBGD@1150|Oscillatoriales	1117|Cyanobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
SX2_k127_4558061_2	1403819.BATR01000022_gene806	7.735e-137	475.0	COG2114@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3903@2|Bacteria,46TZ3@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,NB-ARC
SX2_k127_4558061_7	1232452.BAIB02000006_gene1385	1.62e-64	231.0	COG1473@1|root,COG1473@2|Bacteria,1TQ7B@1239|Firmicutes,2492H@186801|Clostridia	186801|Clostridia	S	amidohydrolase	-	-	-	ko:K12941	-	-	-	-	ko00000,ko01002	-	-	-	M20_dimer,Peptidase_M20
SX2_k127_4569771_0	744872.Spica_1845	3.006e-232	735.0	COG0737@1|root,COG0737@2|Bacteria,2J5ZK@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.6,3.1.4.16	ko:K01119	ko00230,ko00240,map00230,map00240	-	R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135	RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
SX2_k127_4569771_2	744872.Spica_0319	7.822e-112	403.0	COG2114@1|root,COG2114@2|Bacteria,2J6ME@203691|Spirochaetes	203691|Spirochaetes	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
SX2_k127_4569771_9	1177594.MIC448_320001	4.799e-05	55.0	COG5621@1|root,COG5621@2|Bacteria,2GNHM@201174|Actinobacteria	201174|Actinobacteria	S	secreted hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CrtC
SX2_k127_4569771_1	1123274.KB899419_gene1979	3.782e-123	411.0	COG0265@1|root,COG0265@2|Bacteria,2J5GT@203691|Spirochaetes	203691|Spirochaetes	O	periplasmic serine protease, Do	htrA	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
SX2_k127_4569771_4	1385935.N836_20840	4.857e-89	317.0	COG2207@1|root,COG3449@1|root,COG2207@2|Bacteria,COG3449@2|Bacteria	2|Bacteria	K	DNA topoisomerase (ATP-hydrolyzing) inhibitor activity	sbmC	GO:0003674,GO:0004857,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006275,GO:0006950,GO:0006974,GO:0008150,GO:0008156,GO:0008657,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0010911,GO:0019219,GO:0019222,GO:0019899,GO:0030234,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032780,GO:0033554,GO:0042030,GO:0043086,GO:0043462,GO:0044092,GO:0044424,GO:0044464,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051336,GO:0051346,GO:0051716,GO:0060255,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0072586,GO:0080090,GO:0090329,GO:0098772,GO:2000104,GO:2000112,GO:2000113,GO:2000371,GO:2000372	-	ko:K07470,ko:K13652	-	-	-	-	ko00000,ko03000	-	-	-	GyrI-like,HTH_18,HTH_AraC
SX2_k127_4569771_3	1499967.BAYZ01000142_gene6163	7.536e-94	317.0	COG1402@1|root,COG1402@2|Bacteria	2|Bacteria	I	creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
SX2_k127_4569771_5	1123274.KB899414_gene3605	3.014e-55	208.0	COG2199@1|root,COG4251@1|root,COG3706@2|Bacteria,COG4251@2|Bacteria,2JAW9@203691|Spirochaetes	203691|Spirochaetes	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
SX2_k127_4569771_7	1151117.AJLF01000001_gene1036	2.316e-28	120.0	COG0784@1|root,arCOG02391@2157|Archaea,2XXBY@28890|Euryarchaeota,2449F@183968|Thermococci	183968|Thermococci	T	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
SX2_k127_4569771_8	497964.CfE428DRAFT_3173	3.809e-23	107.0	COG0673@1|root,COG0673@2|Bacteria,46TMF@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
SX2_k127_4572819_1	452637.Oter_1254	2.331e-66	231.0	COG0519@1|root,COG0519@2|Bacteria,46SIW@74201|Verrucomicrobia,3K77S@414999|Opitutae	2|Bacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
SX2_k127_4572819_0	1499967.BAYZ01000095_gene4185	1.612e-115	392.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
SX2_k127_4572819_2	1227352.C173_17831	1.716e-25	112.0	COG1653@1|root,COG1653@2|Bacteria,1V0NW@1239|Firmicutes,4IR6F@91061|Bacilli,276NY@186822|Paenibacillaceae	91061|Bacilli	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_1
SX2_k127_4578748_1	906968.Trebr_2416	5.018e-45	165.0	COG2812@1|root,COG2812@2|Bacteria,2J5A9@203691|Spirochaetes	203691|Spirochaetes	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
SX2_k127_4578748_0	573413.Spirs_0088	2.361e-101	344.0	COG2812@1|root,COG2812@2|Bacteria,2J5A9@203691|Spirochaetes	203691|Spirochaetes	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
SX2_k127_458641_0	665571.STHERM_c14380	1.309e-194	613.0	COG0423@1|root,COG0423@2|Bacteria,2J57N@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
SX2_k127_458641_1	1286171.EAL2_808p05590	2.055e-150	486.0	COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,247QC@186801|Clostridia,25URF@186806|Eubacteriaceae	186801|Clostridia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
SX2_k127_4586893_3	1502724.FF80_00062	7.767e-72	252.0	COG1215@1|root,COG1215@2|Bacteria,1RE2E@1224|Proteobacteria,2U721@28211|Alphaproteobacteria,3N7KK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SX2_k127_4586893_4	665571.STHERM_c10760	2.144e-47	177.0	COG0727@1|root,COG0727@2|Bacteria,2J85V@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Uncharacterised protein family (UPF0153)	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
SX2_k127_4586893_1	1123274.KB899421_gene1815	9.404e-102	340.0	COG1235@1|root,COG1235@2|Bacteria,2J5C5@203691|Spirochaetes	203691|Spirochaetes	S	Metallo-beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
SX2_k127_4586893_0	573413.Spirs_2081	0.0	1041.0	COG2885@1|root,COG2885@2|Bacteria,2J5KD@203691|Spirochaetes	203691|Spirochaetes	M	ompA family	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3,CHU_C,FlgD_ig,OmpA
SX2_k127_4586893_2	573413.Spirs_2080	2.517e-76	267.0	COG1559@1|root,COG1559@2|Bacteria,2J5V4@203691|Spirochaetes	203691|Spirochaetes	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
SX2_k127_4592512_0	1283300.ATXB01000001_gene1253	7.221e-103	349.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1XFDE@135618|Methylococcales	135618|Methylococcales	L	PFAM RNA-directed DNA polymerase (reverse transcriptase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
SX2_k127_4593088_10	667014.Thein_0552	1.109e-46	173.0	COG0216@1|root,COG0216@2|Bacteria,2GHCQ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
SX2_k127_4593088_6	309801.trd_1178	1.435e-90	316.0	COG1109@1|root,COG1109@2|Bacteria,2G5YP@200795|Chloroflexi,27XV0@189775|Thermomicrobia	189775|Thermomicrobia	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
SX2_k127_4593088_4	1123274.KB899409_gene442	6.454e-111	382.0	COG1022@1|root,COG1022@2|Bacteria,2J59B@203691|Spirochaetes	203691|Spirochaetes	I	COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming)	faa1	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
SX2_k127_4593088_0	744872.Spica_0750	1.064e-174	571.0	COG0488@1|root,COG0488@2|Bacteria,2J5AN@203691|Spirochaetes	203691|Spirochaetes	S	ABC transporter, ATP-binding protein	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
SX2_k127_4593088_9	1480694.DC28_05235	1.312e-49	204.0	2F4TS@1|root,33XG8@2|Bacteria,2J5NM@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
SX2_k127_4593088_1	596151.DesfrDRAFT_1958	3.6e-129	441.0	COG0624@1|root,COG0624@2|Bacteria,1QA8S@1224|Proteobacteria,42NAJ@68525|delta/epsilon subdivisions,2X5JD@28221|Deltaproteobacteria,2MG8U@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	TIGRFAM acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
SX2_k127_4593088_12	596324.TREVI0001_2259	8.908e-29	129.0	COG2885@1|root,COG2885@2|Bacteria,2J5X0@203691|Spirochaetes	203691|Spirochaetes	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
SX2_k127_4593088_7	1123274.KB899412_gene1528	2.406e-78	288.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,2J5H1@203691|Spirochaetes	203691|Spirochaetes	M	Transglycosylase	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
SX2_k127_4593088_8	573413.Spirs_2857	1.012e-75	270.0	COG0457@1|root,COG0457@2|Bacteria,2J5XK@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_6,TPR_8
SX2_k127_4593088_13	1321815.HMPREF9193_01562	1.316e-17	91.0	2AMU1@1|root,31CQJ@2|Bacteria,2J8GB@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4593088_2	889378.Spiaf_0091	2.993e-127	430.0	COG1306@1|root,COG1306@2|Bacteria,2J5BQ@203691|Spirochaetes	203691|Spirochaetes	S	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
SX2_k127_4593088_3	744872.Spica_2556	7.828e-119	408.0	COG1413@1|root,COG2211@1|root,COG1413@2|Bacteria,COG2211@2|Bacteria,2J9QA@203691|Spirochaetes	203691|Spirochaetes	CG	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
SX2_k127_4593088_5	760011.Spico_1318	6.705e-106	372.0	COG0826@1|root,COG0826@2|Bacteria,2J667@203691|Spirochaetes	203691|Spirochaetes	O	Peptidase U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
SX2_k127_4593088_11	665571.STHERM_c21800	3.724e-33	134.0	COG0791@1|root,COG0791@2|Bacteria,2JB19@203691|Spirochaetes	203691|Spirochaetes	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	CHAP,NLPC_P60
SX2_k127_4595492_8	907348.TresaDRAFT_1770	0.0005913	44.0	COG1436@1|root,COG1436@2|Bacteria,2J8AJ@203691|Spirochaetes	203691|Spirochaetes	C	-ATPase subunit F	-	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
SX2_k127_4595492_6	545695.TREAZ_3403	6.705e-27	113.0	COG0636@1|root,COG0636@2|Bacteria,2J8ME@203691|Spirochaetes	203691|Spirochaetes	P	ATP synthase subunit C	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
SX2_k127_4595492_0	744872.Spica_1820	5.757e-155	512.0	COG1269@1|root,COG1269@2|Bacteria,2J6DX@203691|Spirochaetes	203691|Spirochaetes	U	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
SX2_k127_4595492_4	907348.TresaDRAFT_1767	9.443e-33	143.0	COG1527@1|root,COG1527@2|Bacteria,2J5RM@203691|Spirochaetes	203691|Spirochaetes	C	ATP synthase (C/AC39) subunit	-	-	-	-	-	-	-	-	-	-	-	-	vATP-synt_AC39
SX2_k127_4595492_3	744872.Spica_1823	6.336e-40	158.0	COG1762@1|root,COG1762@2|Bacteria,2J7SC@203691|Spirochaetes	203691|Spirochaetes	GT	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	-	-	2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2
SX2_k127_4595492_7	1123274.KB899419_gene1973	6.155e-24	111.0	COG1314@1|root,COG1314@2|Bacteria,2J7UR@203691|Spirochaetes	203691|Spirochaetes	U	Preprotein translocase SecG subunit	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
SX2_k127_4595492_2	665571.STHERM_c09810	1.003e-91	307.0	COG0149@1|root,COG0149@2|Bacteria,2J5FV@203691|Spirochaetes	203691|Spirochaetes	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
SX2_k127_4595492_1	760011.Spico_0472	3.54e-149	494.0	COG0126@1|root,COG0126@2|Bacteria,2J68Y@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
SX2_k127_4595492_5	545695.TREAZ_3664	6.151e-31	130.0	COG0457@1|root,COG0457@2|Bacteria,2J5SR@203691|Spirochaetes	203691|Spirochaetes	S	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC3,TPR_16,TPR_19,TPR_6,TPR_8
SX2_k127_4603902_1	1121271.AUCM01000001_gene3648	3.128e-148	492.0	COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,2TRD7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
SX2_k127_4603902_3	665571.STHERM_c06570	3.392e-15	89.0	290DX@1|root,32INT@2|Bacteria,2J83J@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4603902_0	1123274.KB899407_gene379	7.871e-151	487.0	COG1435@1|root,COG1435@2|Bacteria,2J6SK@203691|Spirochaetes	203691|Spirochaetes	F	thymidine kinase	tdk	-	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TK
SX2_k127_4603902_2	1499967.BAYZ01000047_gene2738	5.18e-66	232.0	COG0053@1|root,COG0053@2|Bacteria,2NPHA@2323|unclassified Bacteria	2|Bacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
SX2_k127_4612383_2	744872.Spica_0389	4.636e-47	170.0	COG0185@1|root,COG0185@2|Bacteria,2J8DX@203691|Spirochaetes	203691|Spirochaetes	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
SX2_k127_4612383_0	1307761.L21SP2_0880	1.719e-122	401.0	COG0090@1|root,COG0090@2|Bacteria,2J5G3@203691|Spirochaetes	203691|Spirochaetes	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
SX2_k127_4612383_3	744872.Spica_0387	3.584e-26	117.0	COG0089@1|root,COG0089@2|Bacteria,2J85B@203691|Spirochaetes	203691|Spirochaetes	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
SX2_k127_4612383_1	243276.TPANIC_0190	1.551e-50	183.0	COG0088@1|root,COG0088@2|Bacteria,2J5NS@203691|Spirochaetes	203691|Spirochaetes	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
SX2_k127_4621465_0	1121405.dsmv_0287	2.49e-250	795.0	COG1042@1|root,COG1042@2|Bacteria,1NU6B@1224|Proteobacteria,42NAU@68525|delta/epsilon subdivisions,2WJHX@28221|Deltaproteobacteria,2MIMR@213118|Desulfobacterales	2|Bacteria	C	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
SX2_k127_4634379_1	1129794.C427_5517	1.064e-91	323.0	COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,1RPFW@1236|Gammaproteobacteria,465DX@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	Carboxylesterase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
SX2_k127_4634379_2	1511.CLOST_1845	1.545e-19	90.0	COG0227@1|root,COG0227@2|Bacteria,1VEI2@1239|Firmicutes,24QNA@186801|Clostridia,25RTD@186804|Peptostreptococcaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
SX2_k127_4634379_0	351627.Csac_0621	2.317e-212	696.0	COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,42EUY@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.17.1.10,1.17.1.9,1.97.1.9	ko:K00123,ko:K12527,ko:K15022	ko00450,ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00450,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519,R07229	RC02420,RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_20,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Pyr_redox_2,Pyr_redox_3
SX2_k127_4634379_3	1151117.AJLF01000002_gene333	5.248e-13	69.0	COG1145@1|root,COG1894@1|root,arCOG01610@2157|Archaea,arCOG04537@2157|Archaea,2XUYN@28890|Euryarchaeota,243V2@183968|Thermococci	183968|Thermococci	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
SX2_k127_4659374_4	573413.Spirs_2049	2.047e-72	259.0	COG0457@1|root,COG0457@2|Bacteria,2J5D0@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19,TPR_2
SX2_k127_4659374_5	913865.DOT_1718	5.61e-44	164.0	COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,24J90@186801|Clostridia,2626H@186807|Peptococcaceae	186801|Clostridia	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	-	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
SX2_k127_4659374_2	269799.Gmet_1654	7.068e-77	272.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,42PDR@68525|delta/epsilon subdivisions,2WJ60@28221|Deltaproteobacteria,43TKZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	endonuclease III	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
SX2_k127_4659374_1	889378.Spiaf_1522	2.319e-112	373.0	COG0462@1|root,COG0462@2|Bacteria,2J68G@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the ribose-phosphate pyrophosphokinase family	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
SX2_k127_4659374_0	1123274.KB899421_gene1781	1.418e-162	522.0	COG0468@1|root,COG0468@2|Bacteria,2J5G5@203691|Spirochaetes	203691|Spirochaetes	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
SX2_k127_4659374_6	545695.TREAZ_0512	4.143e-30	135.0	COG0801@1|root,COG0801@2|Bacteria,2J8EN@203691|Spirochaetes	203691|Spirochaetes	H	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
SX2_k127_4659374_3	889378.Spiaf_1519	2.399e-73	263.0	COG1354@1|root,COG1354@2|Bacteria,2J5RF@203691|Spirochaetes	203691|Spirochaetes	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
SX2_k127_4668174_2	1191523.MROS_2481	2.674e-128	427.0	COG1894@1|root,COG3411@1|root,COG1894@2|Bacteria,COG3411@2|Bacteria	2|Bacteria	C	Ferredoxin	hoxF	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K05587,ko:K17992,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
SX2_k127_4668174_8	880073.Calab_1429	1.285e-42	161.0	COG1905@1|root,COG1905@2|Bacteria,2NPSB@2323|unclassified Bacteria	2|Bacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	1.12.1.4,1.6.5.3	ko:K00334,ko:K17999	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
SX2_k127_4668174_12	269800.Tfu_2117	3.711e-27	119.0	COG1011@1|root,COG1011@2|Bacteria,2IHVB@201174|Actinobacteria,4EK45@85012|Streptosporangiales	201174|Actinobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
SX2_k127_4668174_11	1123487.KB892835_gene3742	1.916e-27	113.0	COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,2WH7G@28216|Betaproteobacteria,2KZQT@206389|Rhodocyclales	1224|Proteobacteria	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057,ko:K10440	ko02010,map02010	M00212,M00221	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
SX2_k127_4668174_6	448385.sce3305	1.627e-61	226.0	COG1172@1|root,COG1172@2|Bacteria,1MW9Z@1224|Proteobacteria,436BT@68525|delta/epsilon subdivisions,2X0WW@28221|Deltaproteobacteria,2YX7X@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
SX2_k127_4668174_9	378806.STAUR_1917	1.791e-41	163.0	COG1172@1|root,COG1172@2|Bacteria,1MUM6@1224|Proteobacteria,432WP@68525|delta/epsilon subdivisions,2WXP4@28221|Deltaproteobacteria,2YWA2@29|Myxococcales	28221|Deltaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
SX2_k127_4668174_0	706587.Desti_4722	6.747e-164	533.0	COG1966@1|root,COG1966@2|Bacteria,1MWF9@1224|Proteobacteria,42NBI@68525|delta/epsilon subdivisions,2WM33@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	carbon starvation protein CstA	cstA	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
SX2_k127_4668174_14	444157.Tneu_0449	2.745e-17	87.0	arCOG03655@1|root,arCOG03655@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4668174_10	706587.Desti_4721	1.476e-38	146.0	2DZFA@1|root,32V98@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4668174_1	706587.Desti_4720	2.107e-141	455.0	COG0003@1|root,COG0003@2|Bacteria,1MUTX@1224|Proteobacteria,42V9Y@68525|delta/epsilon subdivisions,2WND5@28221|Deltaproteobacteria,2MS8W@213462|Syntrophobacterales	28221|Deltaproteobacteria	D	Anion-transporting ATPase	arsA	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
SX2_k127_4668174_3	706587.Desti_4719	9.453e-126	435.0	COG0003@1|root,COG0003@2|Bacteria,1MUTX@1224|Proteobacteria,42V9Y@68525|delta/epsilon subdivisions,2WND5@28221|Deltaproteobacteria,2MS8W@213462|Syntrophobacterales	28221|Deltaproteobacteria	D	Anion-transporting ATPase	arsA	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
SX2_k127_4668174_5	1033743.CAES01000045_gene184	2.062e-65	254.0	COG2197@1|root,COG2197@2|Bacteria,1V3UP@1239|Firmicutes,4HI7B@91061|Bacilli,26S14@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
SX2_k127_4668174_4	293826.Amet_3716	1.15e-93	321.0	COG4585@1|root,COG4585@2|Bacteria,1UUZ9@1239|Firmicutes,248T2@186801|Clostridia,36W11@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3,HisKA_7TM
SX2_k127_4668174_7	649639.Bcell_1296	5.71e-46	182.0	COG1511@1|root,COG1511@2|Bacteria,1V29V@1239|Firmicutes,4HFPS@91061|Bacilli,1ZQEJ@1386|Bacillus	91061|Bacilli	S	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
SX2_k127_4668174_13	1462527.CCDM010000002_gene1518	4.427e-22	103.0	COG0842@1|root,COG0842@2|Bacteria,1V5GP@1239|Firmicutes,4HH0T@91061|Bacilli,23N41@182709|Oceanobacillus	91061|Bacilli	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
SX2_k127_4676807_4	644282.Deba_1685	9.126e-47	185.0	COG0600@1|root,COG1116@1|root,COG0600@2|Bacteria,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,42QRU@68525|delta/epsilon subdivisions,2WMNQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ABC transporter	-	-	-	ko:K02049,ko:K15555,ko:K15600	ko00920,ko02010,map00920,map02010	M00188,M00436,M00442	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.2,3.A.1.17.3,3.A.1.17.6	-	-	ABC_tran
SX2_k127_4676807_2	309799.DICTH_0141	2.491e-86	317.0	COG2379@1|root,COG2379@2|Bacteria	2|Bacteria	G	hydroxypyruvate reductase	ttuD	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
SX2_k127_4676807_5	1480694.DC28_02915	3.69e-10	72.0	298IC@1|root,2ZVPA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4676807_0	1122925.KB895385_gene3055	2.499e-114	380.0	COG1168@1|root,COG1168@2|Bacteria,1TP5G@1239|Firmicutes,4H9PE@91061|Bacilli,26TMT@186822|Paenibacillaceae	91061|Bacilli	E	Cystathionine beta-lyase	patB	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
SX2_k127_4676807_1	1499967.BAYZ01000095_gene4075	1.077e-86	296.0	COG2220@1|root,COG2220@2|Bacteria,2NQD1@2323|unclassified Bacteria	2|Bacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
SX2_k127_4676807_3	1307761.L21SP2_1267	3.45e-81	294.0	2F00C@1|root,33T4C@2|Bacteria,2J5MS@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4726634_1	1248916.ANFY01000010_gene378	3.263e-09	70.0	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,2TV7G@28211|Alphaproteobacteria,2K09E@204457|Sphingomonadales	204457|Sphingomonadales	S	Competence protein	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
SX2_k127_4726634_0	545694.TREPR_2630	5.863e-153	496.0	COG0249@1|root,COG0249@2|Bacteria,2J5XM@203691|Spirochaetes	203691|Spirochaetes	L	This protein is involved in the repair of mismatches in DNA	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
SX2_k127_4727182_2	1265505.ATUG01000002_gene2168	1.593e-80	274.0	COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,42NTY@68525|delta/epsilon subdivisions,2WK4F@28221|Deltaproteobacteria,2MIER@213118|Desulfobacterales	28221|Deltaproteobacteria	S	ABC transporter	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
SX2_k127_4727182_0	665571.STHERM_c19120	1.957e-166	534.0	COG1744@1|root,COG1744@2|Bacteria,2J7UH@203691|Spirochaetes	203691|Spirochaetes	S	Membrane protein, bmp family	-	-	-	ko:K02058,ko:K07335	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
SX2_k127_4727182_1	391625.PPSIR1_24484	2.779e-148	476.0	COG3392@1|root,COG3392@2|Bacteria,1R6P4@1224|Proteobacteria,42ND7@68525|delta/epsilon subdivisions	1224|Proteobacteria	L	DNA methyltransferase	fokIM	-	2.1.1.72	ko:K07318	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	MethyltransfD12
SX2_k127_4727620_7	744872.Spica_2384	1.287e-25	110.0	2AMDJ@1|root,31C90@2|Bacteria,2J6DK@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4727620_2	573413.Spirs_1023	1.886e-130	429.0	COG0436@1|root,COG0436@2|Bacteria,2J5R0@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
SX2_k127_4727620_1	665571.STHERM_c21600	1.047e-298	929.0	COG1274@1|root,COG1274@2|Bacteria,2J5BB@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
SX2_k127_4727620_4	665571.STHERM_c03320	2.684e-79	279.0	2EYH2@1|root,33RQY@2|Bacteria,2J9M4@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4727620_3	596324.TREVI0001_1542	4.415e-126	419.0	COG0771@1|root,COG0771@2|Bacteria,2J5IW@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
SX2_k127_4727620_0	439235.Dalk_4850	0.0	1148.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2MIP0@213118|Desulfobacterales	28221|Deltaproteobacteria	I	BadF BadG BcrA BcrD	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
SX2_k127_4727620_5	552811.Dehly_1194	1.569e-78	269.0	COG1592@1|root,COG1592@2|Bacteria	2|Bacteria	C	Rubrerythrin	rbr	GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
SX2_k127_4727620_6	933262.AXAM01000034_gene1574	4.361e-51	194.0	COG2109@1|root,COG2109@2|Bacteria,1MUN6@1224|Proteobacteria,42RPD@68525|delta/epsilon subdivisions,2WNI0@28221|Deltaproteobacteria,2MK1B@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
SX2_k127_4727620_8	665571.STHERM_c12280	6.03e-21	107.0	COG0738@1|root,COG0738@2|Bacteria,2J7KW@203691|Spirochaetes	203691|Spirochaetes	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX2_k127_4727987_3	1121930.AQXG01000011_gene1730	2.26e-18	94.0	COG0697@1|root,COG0697@2|Bacteria,4PJ9B@976|Bacteroidetes,1IZEH@117747|Sphingobacteriia	976|Bacteroidetes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SX2_k127_4727987_2	1304874.JAFY01000002_gene791	3.611e-81	283.0	COG0745@1|root,COG0745@2|Bacteria,3TAJR@508458|Synergistetes	1304874.JAFY01000002_gene791|-	K	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4727987_1	1304874.JAFY01000002_gene790	2.757e-99	357.0	COG5002@1|root,COG5002@2|Bacteria,3T9XA@508458|Synergistetes	2|Bacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
SX2_k127_4727987_0	494419.ALPM01000049_gene2746	4.567e-180	588.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,2GKFE@201174|Actinobacteria	201174|Actinobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
SX2_k127_4753963_0	1123274.KB899414_gene3685	1.07e-126	412.0	COG1235@1|root,COG1235@2|Bacteria,2J6YX@203691|Spirochaetes	203691|Spirochaetes	S	Beta-lactamase superfamily domain	elaC	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Lactamase_B_2
SX2_k127_4753963_1	573413.Spirs_4078	1.916e-121	401.0	COG1639@1|root,COG1639@2|Bacteria,2J74B@203691|Spirochaetes	203691|Spirochaetes	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
SX2_k127_4753963_2	744872.Spica_2727	1.942e-90	339.0	COG0457@1|root,COG0457@2|Bacteria,2J58Z@203691|Spirochaetes	203691|Spirochaetes	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_19,TPR_2,TPR_7,TPR_8
SX2_k127_4753963_3	573413.Spirs_4076	4.403e-86	303.0	COG4733@1|root,COG4733@2|Bacteria,2JBHZ@203691|Spirochaetes	203691|Spirochaetes	S	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,fn3
SX2_k127_4753963_4	877418.ATWV01000011_gene67	1.46e-22	111.0	COG0322@1|root,COG0322@2|Bacteria,2J69M@203691|Spirochaetes	203691|Spirochaetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
SX2_k127_4764409_2	889378.Spiaf_1955	9.791e-34	136.0	COG0299@1|root,COG0299@2|Bacteria	2|Bacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N,YjbR
SX2_k127_4764409_3	584708.Apau_1182	4.286e-15	78.0	COG0150@1|root,COG0150@2|Bacteria,3T9QB@508458|Synergistetes	508458|Synergistetes	F	PFAM AIR synthase related protein	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
SX2_k127_4764409_1	1307761.L21SP2_1362	4.033e-78	269.0	COG0150@1|root,COG0150@2|Bacteria,2J5AP@203691|Spirochaetes	203691|Spirochaetes	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
SX2_k127_4764409_0	665571.STHERM_c18650	1.619e-86	298.0	COG0042@1|root,COG0042@2|Bacteria,2J691@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	-	-	-	-	-	-	-	-	-	-	-	-	Dus
SX2_k127_4764409_4	665571.STHERM_c18640	7.645e-07	51.0	COG0084@1|root,COG0084@2|Bacteria,2J68W@203691|Spirochaetes	203691|Spirochaetes	L	Hydrolase, TatD family	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
SX2_k127_4769409_4	665571.STHERM_c12280	8.905e-28	121.0	COG0738@1|root,COG0738@2|Bacteria,2J7KW@203691|Spirochaetes	203691|Spirochaetes	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX2_k127_4769409_0	1191523.MROS_1835	0.0	1262.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria	2|Bacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
SX2_k127_4769409_1	861299.J421_5728	4.361e-105	377.0	COG4191@1|root,COG4936@1|root,COG4191@2|Bacteria,COG4936@2|Bacteria,1ZUC5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,Response_reg
SX2_k127_4769409_3	1304284.L21TH_0785	3.496e-50	198.0	COG5522@1|root,COG5522@2|Bacteria,1V4XE@1239|Firmicutes,24Q8V@186801|Clostridia,36KVT@31979|Clostridiaceae	186801|Clostridia	S	Integral membrane protein (intg_mem_TP0381)	-	-	-	-	-	-	-	-	-	-	-	-	Intg_mem_TP0381
SX2_k127_4769409_5	1463856.JOHY01000010_gene5937	9.311e-19	100.0	COG0454@1|root,COG0456@2|Bacteria,2I2W1@201174|Actinobacteria	201174|Actinobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,FR47
SX2_k127_4769409_2	530564.Psta_0489	9.96e-81	273.0	COG1207@1|root,COG1207@2|Bacteria,2IXBV@203682|Planctomycetes	203682|Planctomycetes	M	Sugar nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_4
SX2_k127_4781224_8	644966.Tmar_1843	7.599e-31	128.0	COG1820@1|root,COG1820@2|Bacteria,1TPFK@1239|Firmicutes,2481N@186801|Clostridia,3WD2A@538999|Clostridiales incertae sedis	186801|Clostridia	G	PFAM Amidohydrolase family	-	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
SX2_k127_4781224_3	926569.ANT_20970	1.601e-79	273.0	COG1121@1|root,COG1121@2|Bacteria,2G7X2@200795|Chloroflexi	200795|Chloroflexi	P	PFAM ABC transporter related	-	-	-	ko:K09820,ko:K11710	ko02010,map02010	M00243,M00319	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15	-	-	ABC_tran
SX2_k127_4781224_0	555079.Toce_2001	9.184e-165	551.0	COG2403@1|root,COG2403@2|Bacteria,1TPZD@1239|Firmicutes,24E2D@186801|Clostridia,42HSE@68295|Thermoanaerobacterales	186801|Clostridia	S	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
SX2_k127_4781224_1	2325.TKV_c05310	4.123e-130	443.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,248I5@186801|Clostridia,42EK4@68295|Thermoanaerobacterales	186801|Clostridia	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3,2.1.3.9	ko:K00611,ko:K09065	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01398,R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
SX2_k127_4781224_9	573413.Spirs_1292	1.484e-20	101.0	29BJG@1|root,2ZG2E@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4781224_2	744872.Spica_1100	7.177e-88	303.0	COG0006@1|root,COG0006@2|Bacteria,2J6QH@203691|Spirochaetes	203691|Spirochaetes	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
SX2_k127_4781224_4	545694.TREPR_3811	1.134e-68	258.0	COG0618@1|root,COG0618@2|Bacteria,2J6GG@203691|Spirochaetes	203691|Spirochaetes	S	DHH superfamily protein, subfamily 1	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
SX2_k127_4781224_10	744872.Spica_1098	4.135e-07	61.0	2AMT3@1|root,31CPK@2|Bacteria,2J8CQ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4781224_5	573413.Spirs_1289	1.068e-53	195.0	COG0127@1|root,COG0127@2|Bacteria,2J7BY@203691|Spirochaetes	203691|Spirochaetes	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
SX2_k127_4781224_6	545694.TREPR_3651	3.823e-50	192.0	2DWJ6@1|root,340MF@2|Bacteria,2JBJP@203691|Spirochaetes	203691|Spirochaetes	S	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
SX2_k127_4781224_7	1125863.JAFN01000001_gene1728	1.803e-41	168.0	COG0477@1|root,COG2814@2|Bacteria,1P2GY@1224|Proteobacteria,42MWI@68525|delta/epsilon subdivisions,2WK29@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX2_k127_4802627_0	706587.Desti_1123	5.589e-120	400.0	COG2855@1|root,COG2855@2|Bacteria,1MVPE@1224|Proteobacteria,42NT6@68525|delta/epsilon subdivisions,2WJ9R@28221|Deltaproteobacteria,2MR46@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Conserved hypothetical protein 698	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
SX2_k127_4802627_3	1227261.HMPREF0043_01813	0.000218	54.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,2IBV1@201174|Actinobacteria,4D5P3@85005|Actinomycetales	201174|Actinobacteria	M	LysM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	LysM,SLT
SX2_k127_4802627_1	876269.ARWA01000001_gene3348	1.316e-66	242.0	COG2518@1|root,COG2518@2|Bacteria,1P9Q9@1224|Proteobacteria,2U4HI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
SX2_k127_4802627_2	335543.Sfum_2180	6.656e-31	134.0	COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,42NG6@68525|delta/epsilon subdivisions,2WIRU@28221|Deltaproteobacteria,2MQH9@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
SX2_k127_480301_1	1268072.PSAB_02965	1.527e-06	59.0	COG4346@1|root,COG5650@1|root,COG4346@2|Bacteria,COG5650@2|Bacteria,1TSHX@1239|Firmicutes,4ISHD@91061|Bacilli,26SCF@186822|Paenibacillaceae	91061|Bacilli	O	Glycosyl transferase	-	-	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	F5_F8_type_C,GT87,PMT,PMT_2,PMT_4TMC
SX2_k127_480301_0	1121346.KB899808_gene3590	1.481e-42	166.0	COG4346@1|root,COG5650@1|root,COG4346@2|Bacteria,COG5650@2|Bacteria,1TSHX@1239|Firmicutes,4ISHD@91061|Bacilli,26SCF@186822|Paenibacillaceae	91061|Bacilli	O	Glycosyl transferase	-	-	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	F5_F8_type_C,GT87,PMT,PMT_2,PMT_4TMC
SX2_k127_4804440_1	2002.JOEQ01000023_gene1273	4.982e-08	63.0	COG1653@1|root,COG1653@2|Bacteria,2GJIP@201174|Actinobacteria,4EGQU@85012|Streptosporangiales	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
SX2_k127_4804440_0	1121861.KB899944_gene3875	5.38e-68	242.0	COG1175@1|root,COG1175@2|Bacteria,1NAGS@1224|Proteobacteria,2TUXQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type sugar transport systems permease components	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX2_k127_4804440_2	1121946.AUAX01000027_gene7899	2.176e-05	55.0	COG0395@1|root,COG0395@2|Bacteria,2GJNJ@201174|Actinobacteria,4D9TF@85008|Micromonosporales	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX2_k127_4814151_0	1121406.JAEX01000006_gene2229	2.132e-47	186.0	COG2887@1|root,COG2887@2|Bacteria,1QUIU@1224|Proteobacteria,42M7I@68525|delta/epsilon subdivisions,2WK89@28221|Deltaproteobacteria,2M83J@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1
SX2_k127_4833232_0	1499967.BAYZ01000009_gene5387	1.054e-60	218.0	COG0407@1|root,COG0407@2|Bacteria,2NRD5@2323|unclassified Bacteria	2|Bacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
SX2_k127_4833232_1	1536775.H70737_05855	3.37e-49	199.0	COG0457@1|root,COG0457@2|Bacteria,1TPP8@1239|Firmicutes,4HCXY@91061|Bacilli,26S7B@186822|Paenibacillaceae	91061|Bacilli	S	Domain of unknown function (DUF5107)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5107,TPR_11,TPR_16,TPR_2,TPR_6,TPR_8
SX2_k127_4855234_0	1173024.KI912152_gene431	2.467e-18	98.0	COG3464@1|root,COG3464@2|Bacteria,1GBZW@1117|Cyanobacteria	1117|Cyanobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_487053_2	1123274.KB899410_gene3573	3.482e-13	83.0	COG0457@1|root,COG0457@2|Bacteria,2J5XG@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
SX2_k127_487053_1	889378.Spiaf_0674	2.539e-32	136.0	COG0296@1|root,COG0296@2|Bacteria,2J5AV@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM
SX2_k127_487053_0	1047013.AQSP01000128_gene411	7.573e-36	145.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SX2_k127_4882896_0	880072.Desac_0080	1.507e-199	634.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions,2WSGG@28221|Deltaproteobacteria,2MSG3@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
SX2_k127_4887436_1	1307761.L21SP2_2844	7.649e-100	336.0	COG0152@1|root,COG0152@2|Bacteria,2J6XZ@203691|Spirochaetes	203691|Spirochaetes	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
SX2_k127_4887436_3	573413.Spirs_3694	1.33e-54	206.0	COG3568@1|root,COG3568@2|Bacteria,2J7FP@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Endonuclease Exonuclease phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
SX2_k127_4887436_0	290397.Adeh_1156	4.872e-123	409.0	COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,42M6S@68525|delta/epsilon subdivisions,2WJU8@28221|Deltaproteobacteria,2YV2H@29|Myxococcales	28221|Deltaproteobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
SX2_k127_4887436_6	889378.Spiaf_2529	2.125e-37	141.0	COG0361@1|root,COG0361@2|Bacteria,2J8JW@203691|Spirochaetes	203691|Spirochaetes	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
SX2_k127_4887436_4	573413.Spirs_0464	7.306e-45	165.0	COG1734@1|root,COG1734@2|Bacteria,2J7Y1@203691|Spirochaetes	203691|Spirochaetes	T	Prokaryotic dksA traR C4-type zinc finger	dksA	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
SX2_k127_4887436_2	573413.Spirs_0466	2.649e-70	244.0	COG0491@1|root,COG0491@2|Bacteria,2J8BJ@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG0491 Zn-dependent hydrolase including glyoxylase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SX2_k127_4887436_7	452637.Oter_0882	1.712e-23	112.0	COG0220@1|root,COG0220@2|Bacteria,46T5A@74201|Verrucomicrobia,3K89Q@414999|Opitutae	414999|Opitutae	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	-	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
SX2_k127_4887436_8	906968.Trebr_0608	3.266e-11	68.0	COG0724@1|root,COG0724@2|Bacteria,2J7A1@203691|Spirochaetes	203691|Spirochaetes	L	DbpA RNA binding domain	-	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA
SX2_k127_4892425_2	1384056.N787_06995	9.058e-14	70.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1RMSS@1236|Gammaproteobacteria,1X3FD@135614|Xanthomonadales	135614|Xanthomonadales	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
SX2_k127_4892425_0	1123257.AUFV01000007_gene186	5.351e-128	421.0	COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria,1RQ57@1236|Gammaproteobacteria,1X34A@135614|Xanthomonadales	135614|Xanthomonadales	G	Belongs to the class I fructose-bisphosphate aldolase family	-	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
SX2_k127_4892425_1	1283300.ATXB01000001_gene736	6.482e-84	285.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,1XET4@135618|Methylococcales	135618|Methylococcales	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
SX2_k127_4893709_1	994573.T472_0207500	1.087e-60	221.0	COG0266@1|root,COG0266@2|Bacteria,1TPM9@1239|Firmicutes,24BH2@186801|Clostridia,36DZN@31979|Clostridiaceae	186801|Clostridia	L	Formamidopyrimidine-DNA glycosylase H2TH domain	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
SX2_k127_4893709_0	870187.Thini_1321	1.331e-72	261.0	COG1373@1|root,COG1373@2|Bacteria,1R7UA@1224|Proteobacteria,1SK42@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_14,DUF4143
SX2_k127_4893709_2	1226325.HMPREF1548_06752	7.872e-19	89.0	COG0814@1|root,COG0814@2|Bacteria,1UTY5@1239|Firmicutes,24BAJ@186801|Clostridia,36SUU@31979|Clostridiaceae	186801|Clostridia	E	Tryptophan/tyrosine permease family	-	-	-	-	-	-	-	-	-	-	-	-	Trp_Tyr_perm
SX2_k127_489722_0	293826.Amet_1269	2.523e-158	514.0	COG0174@1|root,COG0174@2|Bacteria,1TNZA@1239|Firmicutes,2489S@186801|Clostridia,36DYK@31979|Clostridiaceae	186801|Clostridia	E	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
SX2_k127_4899289_0	1121428.DESHY_110410___1	3.384e-143	499.0	COG1148@1|root,COG1148@2|Bacteria,1V5YJ@1239|Firmicutes	1239|Firmicutes	C	binding domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,Pyr_redox_2
SX2_k127_4899289_1	913865.DOT_0091	1.501e-79	280.0	COG0247@1|root,COG0247@2|Bacteria,1TPG1@1239|Firmicutes,24HJC@186801|Clostridia,264WD@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_10,Fer4_8
SX2_k127_4899289_2	1515613.HQ37_01835	1.205e-29	127.0	COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,4PKEU@976|Bacteroidetes,2FKZ0@200643|Bacteroidia,22WZ3@171551|Porphyromonadaceae	976|Bacteroidetes	P	Belongs to the sulfur carrier protein TusA family	cdr	-	-	-	-	-	-	-	-	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
SX2_k127_4899289_3	319225.Plut_0042	3.787e-18	93.0	COG2168@1|root,COG2168@2|Bacteria,1FFCU@1090|Chlorobi	1090|Chlorobi	P	PFAM DsrH family protein	-	-	-	ko:K07237	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DsrH
SX2_k127_4899289_4	290315.Clim_0700	6.565e-18	88.0	COG2923@1|root,COG2923@2|Bacteria,1FF55@1090|Chlorobi	1090|Chlorobi	P	PFAM DsrE family protein	-	-	-	ko:K07236	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DrsE
SX2_k127_4924224_1	316067.Geob_2704	4.278e-36	159.0	COG5184@1|root,COG5279@1|root,COG5184@2|Bacteria,COG5279@2|Bacteria,1QX3H@1224|Proteobacteria	1224|Proteobacteria	DZ	regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin-like
SX2_k127_4924224_0	452637.Oter_1377	1.84e-269	844.0	COG5426@1|root,COG5426@2|Bacteria	2|Bacteria	D	von Willebrand factor, type A	M1-1040	-	2.4.1.247	ko:K15534	-	-	-	-	ko00000,ko01000	-	-	-	LBP_C,LBP_M,Lact_bio_phlase
SX2_k127_4931644_3	665571.STHERM_c10720	9.803e-33	136.0	2FG0B@1|root,347X1@2|Bacteria,2J8HA@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4931644_1	429009.Adeg_1046	4.057e-63	235.0	COG1454@1|root,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,247IQ@186801|Clostridia,42FVU@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Iron-containing alcohol dehydrogenase	dhaT1	-	1.1.1.1,1.1.1.202	ko:K00086,ko:K13954	ko00010,ko00071,ko00350,ko00561,ko00625,ko00626,ko00640,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00561,map00625,map00626,map00640,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02377,R03119,R04880,R05233,R05234,R06917,R06927	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
SX2_k127_4931644_4	1048339.KB913029_gene4086	1.348e-19	104.0	COG4401@1|root,COG4401@2|Bacteria,2IHWT@201174|Actinobacteria,4ET13@85013|Frankiales	201174|Actinobacteria	E	Chorismate mutase type I	-	-	5.4.99.5	ko:K06208	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_1
SX2_k127_4931644_0	1123371.ATXH01000021_gene1119	1.926e-110	379.0	COG0297@1|root,COG0297@2|Bacteria,2GI6I@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	G	Starch synthase catalytic domain	-	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
SX2_k127_4931644_2	255470.cbdbA460	5.086e-42	162.0	COG0024@1|root,COG0024@2|Bacteria,2G6AV@200795|Chloroflexi,34CJJ@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Metallopeptidase family M24	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
SX2_k127_4934228_0	573413.Spirs_2295	8.886e-79	271.0	COG0439@1|root,COG0439@2|Bacteria,2J5D2@203691|Spirochaetes	203691|Spirochaetes	I	Biotin carboxylase	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
SX2_k127_4934228_2	665571.STHERM_c08560	9.158e-41	156.0	COG0511@1|root,COG0511@2|Bacteria,2J83W@203691|Spirochaetes	203691|Spirochaetes	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
SX2_k127_4934228_1	1480694.DC28_11550	7.799e-46	171.0	COG0764@1|root,COG0764@2|Bacteria,2J7PK@203691|Spirochaetes	203691|Spirochaetes	I	dehydratase	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
SX2_k127_4934228_3	796945.HMPREF1145_1962	7.33e-20	100.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia	186801|Clostridia	NT	methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
SX2_k127_494910_4	1125699.HMPREF9194_01193	9.27e-15	76.0	COG1643@1|root,COG1643@2|Bacteria,2J58M@203691|Spirochaetes	203691|Spirochaetes	L	Helicase	hrpA	-	-	-	-	-	-	-	-	-	-	-	DEAD,HA2,Helicase_C,OB_NTP_bind
SX2_k127_494910_3	744872.Spica_0136	9.59e-26	123.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	cNMP_binding
SX2_k127_494910_1	665571.STHERM_c15820	7.563e-82	285.0	COG0337@1|root,COG0337@2|Bacteria,2J69J@203691|Spirochaetes	203691|Spirochaetes	H	3-dehydroquinate synthase	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
SX2_k127_494910_0	429009.Adeg_1149	1.238e-97	336.0	COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,2488G@186801|Clostridia,42ER2@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
SX2_k127_494910_2	545694.TREPR_3813	5.675e-72	252.0	COG0613@1|root,COG0613@2|Bacteria,2J69S@203691|Spirochaetes	203691|Spirochaetes	S	PHP domain protein	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
SX2_k127_4966517_1	1480694.DC28_09140	1.317e-13	85.0	COG1538@1|root,COG1538@2|Bacteria,2J914@203691|Spirochaetes	203691|Spirochaetes	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
SX2_k127_4966517_0	1480694.DC28_09150	2.293e-225	723.0	COG0841@1|root,COG0841@2|Bacteria,2J5HW@203691|Spirochaetes	203691|Spirochaetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
SX2_k127_498692_0	1195236.CTER_0329	1.06e-92	320.0	COG2608@1|root,COG2836@1|root,COG4633@1|root,COG2608@2|Bacteria,COG2836@2|Bacteria,COG4633@2|Bacteria,1TQ02@1239|Firmicutes,249HC@186801|Clostridia,3WNAJ@541000|Ruminococcaceae	186801|Clostridia	P	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1,DsbD_2,HMA
SX2_k127_498692_1	573413.Spirs_2888	4.902e-76	265.0	COG2348@1|root,COG2348@2|Bacteria,2J58H@203691|Spirochaetes	203691|Spirochaetes	V	Methicillin resistance protein	femA	-	-	-	-	-	-	-	-	-	-	-	FemAB
SX2_k127_4999125_4	1123274.KB899415_gene2481	4.409e-26	109.0	COG0228@1|root,COG0228@2|Bacteria,2J8AD@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
SX2_k127_4999125_3	1123274.KB899415_gene2482	3.791e-29	123.0	COG1837@1|root,COG1837@2|Bacteria,2J92T@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the UPF0109 family	yhbY	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
SX2_k127_4999125_2	665571.STHERM_c10550	8.586e-42	163.0	COG0806@1|root,COG0806@2|Bacteria,2J73Y@203691|Spirochaetes	203691|Spirochaetes	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
SX2_k127_4999125_0	1123274.KB899415_gene2484	4.029e-84	294.0	COG0336@1|root,COG0336@2|Bacteria,2J5KR@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
SX2_k127_4999125_1	889378.Spiaf_1216	3.959e-42	163.0	COG0335@1|root,COG0335@2|Bacteria,2J825@203691|Spirochaetes	203691|Spirochaetes	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
SX2_k127_5032087_3	234267.Acid_1400	3.778e-79	267.0	COG0422@1|root,COG0422@2|Bacteria,3Y2TX@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
SX2_k127_5032087_0	335543.Sfum_3244	4.272e-171	544.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NM8@68525|delta/epsilon subdivisions,2WIWB@28221|Deltaproteobacteria,2MRBG@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
SX2_k127_5032087_7	335543.Sfum_3244	1.179e-07	53.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NM8@68525|delta/epsilon subdivisions,2WIWB@28221|Deltaproteobacteria,2MRBG@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
SX2_k127_5032087_1	880073.Calab_2356	1.119e-142	495.0	COG0574@1|root,COG0574@2|Bacteria,2NQHP@2323|unclassified Bacteria	2|Bacteria	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transf_2,PPDK_N,Response_reg
SX2_k127_5032087_6	926560.KE387027_gene896	1.563e-14	83.0	COG4758@1|root,COG4758@2|Bacteria,1WKNW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154
SX2_k127_5032087_5	926560.KE387023_gene1958	1.088e-16	87.0	2DRNI@1|root,33CD9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5032087_4	1121405.dsmv_0777	2.528e-42	179.0	COG0309@1|root,COG0546@1|root,COG0309@2|Bacteria,COG0546@2|Bacteria,1N04A@1224|Proteobacteria,437IA@68525|delta/epsilon subdivisions,2WYKF@28221|Deltaproteobacteria,2MP0D@213118|Desulfobacterales	28221|Deltaproteobacteria	O	AIR synthase related protein, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AIRS,AIRS_C
SX2_k127_5032087_2	1453500.AT05_07410	5.72e-131	431.0	COG0436@1|root,COG0436@2|Bacteria,4NG6G@976|Bacteroidetes,1HY78@117743|Flavobacteriia	976|Bacteroidetes	E	Catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate	aspC	-	2.6.1.1,2.6.1.2,2.6.1.66	ko:K00812,ko:K14260	ko00220,ko00250,ko00270,ko00290,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00290,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00258,R00355,R00694,R00734,R00896,R01215,R02433,R02619,R05052	RC00006,RC00008,RC00036	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
SX2_k127_5032087_8	1304874.JAFY01000002_gene1062	3.44e-05	48.0	COG0585@1|root,COG0585@2|Bacteria,3TCDY@508458|Synergistetes	508458|Synergistetes	J	PFAM tRNA pseudouridine synthase D TruD	-	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
SX2_k127_5039527_1	1307761.L21SP2_3449	1.193e-108	360.0	COG2211@1|root,COG2211@2|Bacteria,2J5PU@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX2_k127_5039527_0	926569.ANT_28210	3.885e-176	569.0	COG0366@1|root,COG0366@2|Bacteria,2G5NW@200795|Chloroflexi	200795|Chloroflexi	G	SMART alpha amylase catalytic sub domain	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459,Malt_amylase_C
SX2_k127_5039527_2	1499967.BAYZ01000164_gene6663	1.257e-75	273.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX2_k127_5039527_3	1123024.AUII01000052_gene3908	8.653e-22	100.0	COG0640@1|root,COG0640@2|Bacteria,2IKPW@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator, arsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
SX2_k127_5039527_4	187272.Mlg_1655	1.76e-21	99.0	COG1553@1|root,COG1553@2|Bacteria,1N021@1224|Proteobacteria,1S99J@1236|Gammaproteobacteria,1WY2D@135613|Chromatiales	135613|Chromatiales	P	TIGRFAM sulfur relay protein TusD DsrE	dsrE	GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0019417,GO:0044237,GO:0055114	-	ko:K07235	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE
SX2_k127_5042373_2	1123274.KB899409_gene556	5.701e-18	84.0	COG0402@1|root,COG0402@2|Bacteria,2J5A0@203691|Spirochaetes	203691|Spirochaetes	F	selenium metabolism protein SsnA	ssnA	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
SX2_k127_5042373_0	926550.CLDAP_01510	6.492e-74	262.0	COG2355@1|root,COG2355@2|Bacteria,2G8C9@200795|Chloroflexi	200795|Chloroflexi	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
SX2_k127_5042373_1	926561.KB900622_gene554	5.156e-58	210.0	COG2071@1|root,COG2071@2|Bacteria,1V1KC@1239|Firmicutes,24JCU@186801|Clostridia,3WAQB@53433|Halanaerobiales	186801|Clostridia	S	Peptidase C26	yvdE	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
SX2_k127_5043375_2	1267535.KB906767_gene3931	4.281e-16	91.0	COG0639@1|root,COG0639@2|Bacteria,3Y3U2@57723|Acidobacteria,2JIPQ@204432|Acidobacteriia	204432|Acidobacteriia	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
SX2_k127_5043375_1	573413.Spirs_2353	1.995e-64	248.0	COG0037@1|root,COG0037@2|Bacteria,2J61I@203691|Spirochaetes	203691|Spirochaetes	H	Belongs to the TtcA family	-	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
SX2_k127_5043375_0	889378.Spiaf_2017	5.603e-110	375.0	COG1078@1|root,COG1078@2|Bacteria,2J64T@203691|Spirochaetes	203691|Spirochaetes	S	HD superfamily phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HD
SX2_k127_505000_7	404589.Anae109_3917	1.637e-07	66.0	COG0457@1|root,COG0457@2|Bacteria	404589.Anae109_3917|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_505000_0	760568.Desku_3183	1.756e-288	926.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,26059@186807|Peptococcaceae	186801|Clostridia	O	Belongs to the ClpA ClpB family	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
SX2_k127_505000_5	401526.TcarDRAFT_0138	1.049e-49	196.0	COG3869@1|root,COG3869@2|Bacteria,1TPBA@1239|Firmicutes,4H347@909932|Negativicutes	909932|Negativicutes	H	Protein-arginine kinase	mcsB	-	2.7.14.1	ko:K19405	-	-	R11090	RC00002,RC00203	ko00000,ko01000	-	-	-	ATP-gua_Ptrans
SX2_k127_505000_6	1089553.Tph_c03700	5.104e-26	115.0	COG3880@1|root,COG3880@2|Bacteria,1V6YM@1239|Firmicutes,24JE8@186801|Clostridia,42G0X@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM UvrB UvrC protein	mcsA	-	-	ko:K19411	-	-	-	-	ko00000	-	-	-	UVR
SX2_k127_505000_4	665571.STHERM_c12410	6.73e-61	233.0	COG4591@1|root,COG4591@2|Bacteria,2J5WV@203691|Spirochaetes	203691|Spirochaetes	M	Permease protein	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
SX2_k127_505000_3	545694.TREPR_1771	4.916e-67	238.0	COG1136@1|root,COG1136@2|Bacteria,2J6WT@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
SX2_k127_505000_1	545695.TREAZ_0012	1.451e-84	300.0	COG4591@1|root,COG4591@2|Bacteria,2J5D9@203691|Spirochaetes	203691|Spirochaetes	M	ABC-type transport system involved in lipoprotein release permease component	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
SX2_k127_505000_2	573413.Spirs_1921	2.687e-74	255.0	COG0552@1|root,COG0552@2|Bacteria,2J5KQ@203691|Spirochaetes	203691|Spirochaetes	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
SX2_k127_5068154_0	1123274.KB899430_gene1685	1.061e-251	786.0	COG0466@1|root,COG0466@2|Bacteria,2J5CV@203691|Spirochaetes	203691|Spirochaetes	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
SX2_k127_5068154_1	573413.Spirs_3789	2.186e-48	190.0	COG1876@1|root,COG1876@2|Bacteria,2J72U@203691|Spirochaetes	203691|Spirochaetes	M	Carboxypeptidase	-	-	3.4.17.14	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	VanY
SX2_k127_5068154_2	1123274.KB899421_gene1719	6.695e-42	161.0	COG0009@1|root,COG0009@2|Bacteria,2J7KX@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the SUA5 family	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
SX2_k127_5068154_3	665571.STHERM_c14800	4.177e-25	120.0	2FFB7@1|root,3478X@2|Bacteria,2J8CB@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5070831_4	1408823.AXUS01000004_gene199	4.823e-11	71.0	COG1309@1|root,COG1309@2|Bacteria,1V0JS@1239|Firmicutes,24FZR@186801|Clostridia	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
SX2_k127_5070831_1	1033810.HLPCO_002491	1.163e-64	227.0	COG0156@1|root,COG0156@2|Bacteria,2NNMX@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	-	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
SX2_k127_5070831_2	1033810.HLPCO_002491	5.32e-56	220.0	COG0156@1|root,COG0156@2|Bacteria,2NNMX@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	-	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
SX2_k127_5070831_0	489825.LYNGBM3L_44820	1.031e-98	342.0	COG0498@1|root,COG0498@2|Bacteria,1GBSB@1117|Cyanobacteria,1HF21@1150|Oscillatoriales	1117|Cyanobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
SX2_k127_5070831_3	706587.Desti_1123	1.925e-34	134.0	COG2855@1|root,COG2855@2|Bacteria,1MVPE@1224|Proteobacteria,42NT6@68525|delta/epsilon subdivisions,2WJ9R@28221|Deltaproteobacteria,2MR46@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Conserved hypothetical protein 698	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
SX2_k127_5079746_2	1121405.dsmv_1544	4.922e-93	316.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WMKF@28221|Deltaproteobacteria,2MMHP@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
SX2_k127_5079746_3	909663.KI867150_gene970	5.036e-88	310.0	COG4191@1|root,COG4191@2|Bacteria,1R89N@1224|Proteobacteria,42QDX@68525|delta/epsilon subdivisions,2WKNA@28221|Deltaproteobacteria,2MR83@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS
SX2_k127_5079746_4	1480694.DC28_02930	8.703e-72	259.0	COG1668@1|root,COG1668@2|Bacteria	2|Bacteria	CP	transmembrane transport	natB	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
SX2_k127_5079746_1	1480694.DC28_02925	2.794e-103	346.0	COG4152@1|root,COG4152@2|Bacteria,2JBF0@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF4162)	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SX2_k127_5079746_0	331869.BAL199_24904	1.157e-141	458.0	COG0673@1|root,COG0673@2|Bacteria,1NVJK@1224|Proteobacteria,2U0NE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	MA20_02630	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
SX2_k127_5126517_0	665571.STHERM_c09530	3.345e-177	614.0	COG2208@1|root,COG2208@2|Bacteria,2J5MN@203691|Spirochaetes	203691|Spirochaetes	KT	Stage II sporulation protein E	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,SpoIIE
SX2_k127_5126517_3	889378.Spiaf_1688	3.998e-35	156.0	2EWYA@1|root,33Q9N@2|Bacteria,2J5N1@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5126517_1	573413.Spirs_1496	3.284e-90	320.0	2EY6N@1|root,33RFB@2|Bacteria,2J5R2@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Uncharacterised protein family UPF0164	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2,UPF0164
SX2_k127_5126517_2	309799.DICTH_0414	2.528e-50	199.0	COG2344@1|root,COG2344@2|Bacteria	2|Bacteria	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
SX2_k127_5126517_4	545694.TREPR_1969	1.297e-34	147.0	COG1694@1|root,COG3956@2|Bacteria,2J5HG@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM MazG family protein	mazG	-	3.6.1.9	ko:K02499,ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
SX2_k127_5143116_0	1499967.BAYZ01000097_gene4327	5.47e-172	551.0	COG1486@1|root,COG1486@2|Bacteria	2|Bacteria	G	melibiose metabolic process	-	-	3.2.1.22,3.2.1.86	ko:K01222,ko:K07406	ko00010,ko00052,ko00500,ko00561,ko00600,ko00603,map00010,map00052,map00500,map00561,map00600,map00603	-	R00839,R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05133,R05134,R05549,R05961,R06091	RC00049,RC00059,RC00171,RC00451,RC00714	ko00000,ko00001,ko01000	-	GT4	-	Glyco_hydro_4,Glyco_hydro_4C
SX2_k127_5143116_2	1499967.BAYZ01000009_gene5320	2.023e-68	246.0	COG0406@1|root,COG0406@2|Bacteria	2|Bacteria	G	alpha-ribazole phosphatase activity	M1-742	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
SX2_k127_5143116_1	1304880.JAGB01000002_gene2183	5.915e-110	381.0	COG0613@1|root,COG0613@2|Bacteria	2|Bacteria	Q	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP
SX2_k127_5143116_4	485917.Phep_0458	4.583e-49	186.0	COG3568@1|root,COG3568@2|Bacteria,4NHNQ@976|Bacteroidetes,1IWEC@117747|Sphingobacteriia	976|Bacteroidetes	L	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
SX2_k127_5143116_3	670487.Ocepr_0115	7.809e-58	214.0	COG0697@1|root,COG0697@2|Bacteria,1WKUM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EG	PFAM EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5143116_5	1521187.JPIM01000170_gene1014	3.627e-47	177.0	COG1064@1|root,COG1064@2|Bacteria,2G829@200795|Chloroflexi	200795|Chloroflexi	S	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N
SX2_k127_5147417_0	1047013.AQSP01000095_gene2314	1.645e-103	356.0	COG0001@1|root,COG0001@2|Bacteria,2NNV5@2323|unclassified Bacteria	2|Bacteria	H	PFAM aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3,NMO
SX2_k127_5147417_1	309798.COPRO5265_1200	1.017e-92	321.0	COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,247QC@186801|Clostridia,42FBT@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
SX2_k127_5147417_2	313596.RB2501_15789	1.379e-87	301.0	COG0564@1|root,COG0564@2|Bacteria,4NFS8@976|Bacteroidetes,1HXBY@117743|Flavobacteriia	976|Bacteroidetes	J	Pseudouridine synthase	rluC	-	5.4.99.23,5.4.99.28,5.4.99.29	ko:K06177,ko:K06180	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	PseudoU_synth_2
SX2_k127_5149894_4	660470.Theba_1946	1.554e-109	371.0	COG1173@1|root,COG1173@2|Bacteria,2GE0Y@200918|Thermotogae	200918|Thermotogae	U	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
SX2_k127_5149894_3	660470.Theba_1947	9.234e-136	443.0	COG0601@1|root,COG0601@2|Bacteria,2GDUZ@200918|Thermotogae	200918|Thermotogae	P	inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
SX2_k127_5149894_0	744872.Spica_2030	6.435e-268	850.0	COG3889@1|root,COG3889@2|Bacteria,2J65D@203691|Spirochaetes	203691|Spirochaetes	S	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
SX2_k127_5149894_2	335541.Swol_2172	2.308e-150	485.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
SX2_k127_5149894_5	926692.AZYG01000047_gene2633	7.836e-45	186.0	COG1033@1|root,COG1033@2|Bacteria,1VSWA@1239|Firmicutes,247R6@186801|Clostridia,3WB6E@53433|Halanaerobiales	186801|Clostridia	S	hydrophobe amphiphile efflux-3 (HAE3) family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
SX2_k127_5149894_1	665571.STHERM_c01570	6.399e-256	801.0	COG0173@1|root,COG0173@2|Bacteria,2J5KG@203691|Spirochaetes	203691|Spirochaetes	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
SX2_k127_5149894_7	1124982.MSI_15590	1.224e-06	58.0	COG0716@1|root,COG0716@2|Bacteria,2J8GW@203691|Spirochaetes	203691|Spirochaetes	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_4
SX2_k127_5149894_6	1122917.KB899667_gene3677	2.226e-28	120.0	COG2272@1|root,COG2272@2|Bacteria,1UXY5@1239|Firmicutes,4HCKV@91061|Bacilli,26WB4@186822|Paenibacillaceae	91061|Bacilli	I	Carboxylesterase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
SX2_k127_5150680_0	1123274.KB899407_gene185	2.459e-193	615.0	COG1639@1|root,COG1639@2|Bacteria,2J5NU@203691|Spirochaetes	203691|Spirochaetes	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
SX2_k127_5150680_4	665571.STHERM_c01650	6.889e-32	125.0	COG0695@1|root,COG0695@2|Bacteria	2|Bacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	nrdH	-	-	ko:K03676,ko:K06191	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
SX2_k127_5150680_1	545695.TREAZ_1653	1.29e-95	341.0	COG0407@1|root,COG0407@2|Bacteria,2JAFK@203691|Spirochaetes	203691|Spirochaetes	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
SX2_k127_5150680_3	1123274.KB899407_gene186	4.198e-48	191.0	COG0566@1|root,COG0566@2|Bacteria,2J6AD@203691|Spirochaetes	203691|Spirochaetes	J	RNA methyltransferase TrmH family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase
SX2_k127_5150680_2	1307761.L21SP2_0136	9.588e-55	201.0	COG1454@1|root,COG1454@2|Bacteria,2J5ZT@203691|Spirochaetes	203691|Spirochaetes	C	alcohol dehydrogenase	eutG	-	1.1.1.1	ko:K13954,ko:K19954	ko00010,ko00071,ko00350,ko00625,ko00626,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R04880,R05233,R05234,R06917,R06927	RC00050,RC00088,RC00099,RC00116,RC00649	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
SX2_k127_5155454_4	797304.Natgr_2806	5.453e-12	78.0	COG0572@1|root,arCOG05133@2157|Archaea,2XU2D@28890|Euryarchaeota,23TVV@183963|Halobacteria	183963|Halobacteria	F	uridine kinase	udk	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
SX2_k127_5155454_0	756272.Plabr_0071	3.514e-125	416.0	COG3635@1|root,COG3635@2|Bacteria,2IY5S@203682|Planctomycetes	203682|Planctomycetes	G	phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
SX2_k127_5155454_1	485913.Krac_4778	2.306e-119	393.0	COG0667@1|root,COG0667@2|Bacteria,2G7TU@200795|Chloroflexi	200795|Chloroflexi	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SX2_k127_5155454_3	479434.Sthe_0478	1.034e-12	81.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SX2_k127_5155454_2	1121468.AUBR01000046_gene1908	1.617e-41	165.0	COG1082@1|root,COG1082@2|Bacteria,1V1Y1@1239|Firmicutes,24Y9G@186801|Clostridia,42HWD@68295|Thermoanaerobacterales	186801|Clostridia	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SX2_k127_5155454_5	390333.Ldb0516	1.776e-07	59.0	COG0572@1|root,COG0572@2|Bacteria,1TQ4V@1239|Firmicutes,4IQTA@91061|Bacilli,3FCEB@33958|Lactobacillaceae	91061|Bacilli	F	Zeta toxin	udk	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
SX2_k127_517428_5	760011.Spico_1653	3.961e-24	107.0	COG0508@1|root,COG0508@2|Bacteria,2J686@203691|Spirochaetes	203691|Spirochaetes	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
SX2_k127_517428_3	1123274.KB899411_gene3131	5.806e-33	130.0	2C3HB@1|root,333QE@2|Bacteria,2J8P5@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_517428_1	1123274.KB899426_gene2832	2.352e-42	168.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	GO:0000166,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0017076,GO:0019219,GO:0019222,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0046983,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
SX2_k127_517428_0	665571.STHERM_c01870	3.291e-75	268.0	2EVQY@1|root,33P4X@2|Bacteria,2J6X8@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_517428_2	665571.STHERM_c01860	2.039e-35	139.0	COG3118@1|root,COG3118@2|Bacteria,2J865@203691|Spirochaetes	203691|Spirochaetes	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
SX2_k127_5175856_4	1122918.KB907273_gene3525	2.464e-52	192.0	COG1011@1|root,COG1011@2|Bacteria,1UV7E@1239|Firmicutes,4I7MW@91061|Bacilli,26X2S@186822|Paenibacillaceae	91061|Bacilli	S	HAD-hyrolase-like	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
SX2_k127_5175856_2	649638.Trad_1980	4.891e-76	269.0	COG1609@1|root,COG1609@2|Bacteria,1WMBZ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	PFAM Bacterial regulatory proteins, lacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
SX2_k127_5175856_1	697281.Mahau_1202	7.983e-125	414.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,42F38@68295|Thermoanaerobacterales	186801|Clostridia	P	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
SX2_k127_5175856_0	324057.Pjdr2_3720	3.895e-127	421.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,4HA4E@91061|Bacilli,26SF5@186822|Paenibacillaceae	91061|Bacilli	EP	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
SX2_k127_5175856_3	1408424.JHYI01000014_gene1254	1.015e-56	199.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4H9PZ@91061|Bacilli,1ZC9B@1386|Bacillus	91061|Bacilli	EP	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components	dppC	-	-	ko:K02034,ko:K15582,ko:K16201	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439,M00566	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.2,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
SX2_k127_5192697_2	1539298.JO41_10720	1.081e-98	359.0	COG0772@1|root,COG0772@2|Bacteria,2J62H@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the SEDS family. MrdB RodA subfamily	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
SX2_k127_5192697_0	744872.Spica_1386	1.279e-197	643.0	COG0768@1|root,COG0768@2|Bacteria,2J595@203691|Spirochaetes	203691|Spirochaetes	M	Penicillin-binding Protein	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
SX2_k127_5192697_6	889378.Spiaf_1506	7.15e-15	87.0	COG2891@1|root,COG2891@2|Bacteria,2J89Q@203691|Spirochaetes	203691|Spirochaetes	M	Rod shape-determining protein (MreD)	mreD	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
SX2_k127_5192697_4	744872.Spica_1388	1.202e-57	211.0	COG1792@1|root,COG1792@2|Bacteria,2J77U@203691|Spirochaetes	203691|Spirochaetes	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
SX2_k127_5192697_1	1123274.KB899421_gene1805	3.051e-172	563.0	COG1077@1|root,COG1077@2|Bacteria,2J59M@203691|Spirochaetes	203691|Spirochaetes	D	cell shape determining protein, MreB Mrl	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
SX2_k127_5192697_3	573413.Spirs_2076	1.77e-62	229.0	COG0457@1|root,COG0457@2|Bacteria,2J7G0@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_8
SX2_k127_5192697_5	889378.Spiaf_1502	2.799e-53	194.0	COG1579@1|root,COG1579@2|Bacteria,2J6JN@203691|Spirochaetes	203691|Spirochaetes	S	Zn-ribbon protein, possibly nucleic acid-binding	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
SX2_k127_5226194_0	744872.Spica_1225	6.343e-236	777.0	COG0178@1|root,COG0178@2|Bacteria,2J5BN@203691|Spirochaetes	203691|Spirochaetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
SX2_k127_5226194_3	744872.Spica_1164	4.086e-161	539.0	COG1193@1|root,COG1193@2|Bacteria,2J59D@203691|Spirochaetes	203691|Spirochaetes	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
SX2_k127_5226194_7	665571.STHERM_c17030	2.35e-74	267.0	COG1162@1|root,COG1162@2|Bacteria,2J5AI@203691|Spirochaetes	203691|Spirochaetes	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase,RsgA_N
SX2_k127_5226194_13	1124982.MSI_22750	2.312e-20	100.0	2EH48@1|root,33AW7@2|Bacteria,2J921@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5226194_14	906968.Trebr_0916	1.044e-14	81.0	COG1357@1|root,COG1357@2|Bacteria,2J652@203691|Spirochaetes	203691|Spirochaetes	S	Pentapeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide,Pentapeptide_4
SX2_k127_5226194_9	158190.SpiGrapes_0332	1.833e-41	171.0	COG0491@1|root,COG0491@2|Bacteria,2J7B4@203691|Spirochaetes	203691|Spirochaetes	S	Metallo-beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SX2_k127_5226194_5	573413.Spirs_2470	2.304e-84	289.0	COG0564@1|root,COG0564@2|Bacteria,2J63B@203691|Spirochaetes	203691|Spirochaetes	J	Responsible for synthesis of pseudouridine from uracil	rluD_1	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
SX2_k127_5226194_15	744872.Spica_1584	4.088e-12	78.0	290S3@1|root,34CB1@2|Bacteria,2J8EJ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5226194_8	1123274.KB899419_gene1943	2.097e-49	188.0	COG0325@1|root,COG0325@2|Bacteria,2J71S@203691|Spirochaetes	203691|Spirochaetes	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
SX2_k127_5226194_10	158190.SpiGrapes_1172	1.553e-29	134.0	COG4720@1|root,COG4720@2|Bacteria	2|Bacteria	P	Psort location CytoplasmicMembrane, score	XK27_01265	-	-	ko:K16923,ko:K16924	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.28,3.A.1.29	-	-	ECF-ribofla_trS
SX2_k127_5226194_11	158190.SpiGrapes_1173	7.565e-28	128.0	COG0619@1|root,COG0619@2|Bacteria,2J7RZ@203691|Spirochaetes	203691|Spirochaetes	P	cobalt transport protein	-	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
SX2_k127_5226194_6	158190.SpiGrapes_1174	1.728e-77	280.0	COG1122@1|root,COG1122@2|Bacteria,2J5SA@203691|Spirochaetes	203691|Spirochaetes	P	ABC transporter	-	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
SX2_k127_5226194_4	1125863.JAFN01000001_gene87	1.024e-87	304.0	COG2461@1|root,COG2461@2|Bacteria,1R5J5@1224|Proteobacteria,42QAZ@68525|delta/epsilon subdivisions,2WQTR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Hemerythrin HHE cation binding domain	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF1858,DUF438,Hemerythrin,PAS_10
SX2_k127_5226194_2	552811.Dehly_0563	6.575e-163	527.0	COG0426@1|root,COG0426@2|Bacteria,2G9HN@200795|Chloroflexi	200795|Chloroflexi	C	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5226194_12	335543.Sfum_2728	1.663e-27	123.0	COG1371@1|root,COG1371@2|Bacteria,1NCP6@1224|Proteobacteria,42VQE@68525|delta/epsilon subdivisions,2WS6C@28221|Deltaproteobacteria,2MQPH@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Archease protein family (MTH1598/TM1083)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
SX2_k127_5226194_1	269799.Gmet_1619	7.176e-200	632.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,42MZN@68525|delta/epsilon subdivisions,2WJGK@28221|Deltaproteobacteria,43SZD@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
SX2_k127_5248517_0	573413.Spirs_1653	1.677e-170	550.0	COG1198@1|root,COG1198@2|Bacteria,2J5B4@203691|Spirochaetes	203691|Spirochaetes	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
SX2_k127_5248517_1	665571.STHERM_c18320	1.577e-61	217.0	COG1573@1|root,COG1573@2|Bacteria,2J612@203691|Spirochaetes	203691|Spirochaetes	L	Uracil-DNA glycosylase, family 4	ung	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
SX2_k127_5250832_0	573413.Spirs_1386	9.787e-249	797.0	COG0493@1|root,COG1145@1|root,COG0493@2|Bacteria,COG1145@2|Bacteria,2J6YZ@203691|Spirochaetes	203691|Spirochaetes	C	Selenate reductase YgfK	gltD	-	1.97.1.9	ko:K12527	ko00450,map00450	-	R07229	RC02420	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2,Pyr_redox_3
SX2_k127_5250832_1	498761.HM1_2652	2.158e-150	486.0	COG0402@1|root,COG0402@2|Bacteria,1TP43@1239|Firmicutes,248IX@186801|Clostridia	186801|Clostridia	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	-	-	3.5.4.28,3.5.4.31,3.5.4.40	ko:K12960,ko:K20810	ko00130,ko00270,ko01100,ko01110,map00130,map00270,map01100,map01110	-	R09660,R10695	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
SX2_k127_5269551_10	1123242.JH636434_gene5468	1.206e-26	111.0	COG1624@1|root,COG1762@1|root,COG1624@2|Bacteria,COG1762@2|Bacteria,2IZY9@203682|Planctomycetes	203682|Planctomycetes	H	DisA bacterial checkpoint controller nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	DisA_N,PTS_EIIA_2
SX2_k127_5269551_4	573413.Spirs_3787	7.005e-66	240.0	COG2114@1|root,COG2114@2|Bacteria,2J9VX@203691|Spirochaetes	203691|Spirochaetes	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5269551_8	1123274.KB899410_gene3503	3.243e-34	144.0	COG2114@1|root,COG2114@2|Bacteria,2JAZ7@203691|Spirochaetes	203691|Spirochaetes	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5269551_2	1089548.KI783301_gene3181	2.032e-115	383.0	COG0012@1|root,COG0012@2|Bacteria,1TPRK@1239|Firmicutes,4H9SQ@91061|Bacilli,3WE9Q@539002|Bacillales incertae sedis	91061|Bacilli	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
SX2_k127_5269551_7	43759.JNWK01000035_gene3293	1.781e-35	150.0	COG1063@1|root,COG1063@2|Bacteria,2GNXK@201174|Actinobacteria	201174|Actinobacteria	E	Dehydrogenase	-	-	1.1.1.303,1.1.1.4	ko:K00004	ko00650,map00650	-	R02855,R02946,R10504	RC00205,RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
SX2_k127_5269551_6	357808.RoseRS_0293	7.313e-52	211.0	COG0308@1|root,COG0308@2|Bacteria,2G75V@200795|Chloroflexi,375Q4@32061|Chloroflexia	32061|Chloroflexia	M	PFAM peptidase M1, membrane alanine aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
SX2_k127_5269551_9	180332.JTGN01000003_gene1999	4.738e-28	128.0	COG0407@1|root,COG0407@2|Bacteria,1UZTT@1239|Firmicutes,24E86@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX2_k127_5269551_1	234267.Acid_6969	2.375e-145	473.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX2_k127_5269551_0	448385.sce5497	1.749e-162	557.0	COG0417@1|root,COG0417@2|Bacteria,1MVY9@1224|Proteobacteria,42Q4K@68525|delta/epsilon subdivisions,2WKQ1@28221|Deltaproteobacteria,2Z1M7@29|Myxococcales	28221|Deltaproteobacteria	L	DNA polymerase type-B family	polB	-	2.7.7.7	ko:K02336	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol_B,DNA_pol_B_exo1,RNase_H_2
SX2_k127_5269551_3	382464.ABSI01000011_gene3127	3.427e-89	307.0	COG0673@1|root,COG0673@2|Bacteria,46UE2@74201|Verrucomicrobia,2IVCT@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
SX2_k127_5269551_5	661478.OP10G_2749	2.58e-57	208.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SX2_k127_5269551_11	1123253.AUBD01000008_gene555	0.0007889	49.0	COG5276@1|root,COG5276@2|Bacteria,1R66X@1224|Proteobacteria,1S05Q@1236|Gammaproteobacteria,1X429@135614|Xanthomonadales	135614|Xanthomonadales	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
SX2_k127_527486_9	759914.BP951000_0893	2.297e-17	83.0	COG3951@1|root,COG3951@2|Bacteria	2|Bacteria	MNO	Flagellar rod assembly protein muramidase FlgJ	flgJ	-	-	ko:K02395,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02035	-	GH23	-	Rod-binding
SX2_k127_527486_4	744872.Spica_0849	3.733e-102	339.0	COG0568@1|root,COG0568@2|Bacteria,2J7R0@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoS	-	-	ko:K03086,ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
SX2_k127_527486_8	665571.STHERM_c07330	1.393e-53	198.0	COG2861@1|root,COG2861@2|Bacteria,2J75Z@203691|Spirochaetes	203691|Spirochaetes	S	Divergent polysaccharide deacetylase	-	-	-	ko:K09798	-	-	-	-	ko00000	-	-	-	Polysacc_deac_2
SX2_k127_527486_2	158190.SpiGrapes_0530	1.513e-133	440.0	COG0533@1|root,COG0533@2|Bacteria,2J5WG@203691|Spirochaetes	203691|Spirochaetes	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
SX2_k127_527486_7	665571.STHERM_c07350	6.243e-62	218.0	COG0503@1|root,COG0503@2|Bacteria,2J7CM@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
SX2_k127_527486_3	882082.SaccyDRAFT_2764	6.737e-110	374.0	COG0673@1|root,COG0673@2|Bacteria,2GJNE@201174|Actinobacteria,4E6I7@85010|Pseudonocardiales	201174|Actinobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N,GFO_IDH_MocA,GFO_IDH_MocA_C
SX2_k127_527486_1	889378.Spiaf_2151	2.731e-144	466.0	COG0035@1|root,COG0035@2|Bacteria,2J5NG@203691|Spirochaetes	203691|Spirochaetes	F	uracil phosphoribosyltransferase	upp	-	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
SX2_k127_527486_0	639282.DEFDS_0062	5.186e-156	497.0	COG0191@1|root,COG0191@2|Bacteria,2GETH@200930|Deferribacteres	200930|Deferribacteres	G	Fructose-bisphosphate aldolase class-II	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
SX2_k127_527486_5	596152.DesU5LDRAFT_2194	1.467e-73	271.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,42P2E@68525|delta/epsilon subdivisions,2WIJQ@28221|Deltaproteobacteria,2MA47@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,LIAS_N,Radical_SAM
SX2_k127_527486_6	1123274.KB899419_gene1902	4.787e-69	247.0	2EY48@1|root,33UVP@2|Bacteria,2J5KT@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar filament outer layer protein FlaA	-	-	-	-	-	-	-	-	-	-	-	-	FlaA
SX2_k127_528635_0	906968.Trebr_0957	6.011e-301	937.0	COG0550@1|root,COG0550@2|Bacteria,2J5BS@203691|Spirochaetes	203691|Spirochaetes	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
SX2_k127_528635_4	243275.TDE_1207	1.91e-63	236.0	COG0758@1|root,COG0758@2|Bacteria,2J6UM@203691|Spirochaetes	203691|Spirochaetes	LU	DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
SX2_k127_528635_5	754027.HMPREF9554_00203	2.127e-34	151.0	COG0457@1|root,COG0457@2|Bacteria,2J7BD@203691|Spirochaetes	203691|Spirochaetes	S	TPR domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_6,TPR_8
SX2_k127_528635_3	889378.Spiaf_2115	3.518e-72	269.0	COG4974@1|root,COG4974@2|Bacteria,2J7GT@203691|Spirochaetes	203691|Spirochaetes	L	Belongs to the 'phage' integrase family	xerC	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
SX2_k127_528635_1	573413.Spirs_1552	1.681e-157	505.0	COG0206@1|root,COG0206@2|Bacteria,2J5EQ@203691|Spirochaetes	203691|Spirochaetes	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
SX2_k127_528635_2	1123274.KB899413_gene866	2.535e-132	429.0	COG0849@1|root,COG0849@2|Bacteria,2J5UK@203691|Spirochaetes	203691|Spirochaetes	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
SX2_k127_5294046_7	1480694.DC28_05060	4.21e-13	70.0	COG0807@1|root,COG0807@2|Bacteria	2|Bacteria	H	GTP cyclohydrolase II activity	ribA	-	3.5.4.25	ko:K01497	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125	R00425	RC00293,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
SX2_k127_5294046_6	1123274.KB899417_gene2080	6.933e-38	148.0	COG2606@1|root,COG2606@2|Bacteria,2J8HJ@203691|Spirochaetes	203691|Spirochaetes	S	YbaK prolyl-tRNA synthetase associated region	ybaK	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
SX2_k127_5294046_4	926569.ANT_12060	5.51e-44	170.0	COG1765@1|root,COG1765@2|Bacteria,2G6Y1@200795|Chloroflexi	200795|Chloroflexi	O	PFAM OsmC family protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
SX2_k127_5294046_3	530564.Psta_2317	3.705e-57	215.0	COG1028@1|root,COG1028@2|Bacteria,2IX1Z@203682|Planctomycetes	203682|Planctomycetes	IQ	with different specificities (related to short-chain alcohol	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SX2_k127_5294046_2	357808.RoseRS_1526	6.227e-86	300.0	COG0404@1|root,COG0404@2|Bacteria,2G5VA@200795|Chloroflexi,3756Q@32061|Chloroflexia	32061|Chloroflexia	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
SX2_k127_5294046_5	279238.Saro_1851	1.319e-39	150.0	COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,2U9BY@28211|Alphaproteobacteria,2K5E0@204457|Sphingomonadales	204457|Sphingomonadales	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
SX2_k127_5294046_1	1128421.JAGA01000002_gene784	6.928e-152	493.0	COG0403@1|root,COG0403@2|Bacteria,2NNP1@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006807,GO:0008150,GO:0008152,GO:0009069,GO:0009987,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019752,GO:0032991,GO:0042133,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901605,GO:1902494,GO:1990204	1.4.4.2	ko:K00281,ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
SX2_k127_5294046_0	926569.ANT_16800	4.21e-196	623.0	COG1003@1|root,COG1003@2|Bacteria,2G5MU@200795|Chloroflexi	200795|Chloroflexi	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
SX2_k127_5330949_7	1394178.AWOO02000008_gene2977	3.81e-18	84.0	COG3333@1|root,COG3333@2|Bacteria,2GJB2@201174|Actinobacteria,4EI7P@85012|Streptosporangiales	201174|Actinobacteria	S	PFAM Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
SX2_k127_5330949_0	706587.Desti_3265	7.331e-84	289.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,42M32@68525|delta/epsilon subdivisions,2WJA4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
SX2_k127_5330949_9	1033730.CAHG01000012_gene1932	4.913e-05	47.0	293R6@1|root,2ZR6U@2|Bacteria,2HRYX@201174|Actinobacteria,4DR6V@85009|Propionibacteriales	201174|Actinobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	ko:K07794	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctB
SX2_k127_5330949_10	690585.JNNU01000013_gene3544	0.0001531	49.0	2AAMV@1|root,30ZZJ@2|Bacteria,1MYEB@1224|Proteobacteria,2VBP9@28211|Alphaproteobacteria,4BHVU@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
SX2_k127_5330949_11	1121405.dsmv_0270	0.0002031	44.0	COG3385@1|root,COG3385@2|Bacteria,1NBHF@1224|Proteobacteria,43BBP@68525|delta/epsilon subdivisions,2WRX0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
SX2_k127_5330949_5	1263831.F543_22830	3.347e-23	105.0	COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria	1224|Proteobacteria	M	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
SX2_k127_5330949_8	935866.JAER01000026_gene3160	7.071e-11	74.0	COG5621@1|root,COG5621@2|Bacteria,2GNHM@201174|Actinobacteria	201174|Actinobacteria	S	secreted hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CrtC
SX2_k127_5330949_2	1128421.JAGA01000002_gene1554	1.197e-62	247.0	COG4585@1|root,COG4585@2|Bacteria,2NR1B@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_3
SX2_k127_5330949_3	1121451.DESAM_22101	2.247e-52	213.0	COG2202@1|root,COG2984@1|root,COG3852@1|root,COG2202@2|Bacteria,COG2984@2|Bacteria,COG3852@2|Bacteria,1NWNJ@1224|Proteobacteria,42NXV@68525|delta/epsilon subdivisions,2X6Z9@28221|Deltaproteobacteria,2MH91@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,HATPase_c,HisKA,PAS,PAS_3
SX2_k127_5330949_6	253839.SSNG_06339	5.947e-19	91.0	COG2197@1|root,COG2197@2|Bacteria,2GN1F@201174|Actinobacteria	201174|Actinobacteria	T	COG COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
SX2_k127_5330949_1	1121434.AULY01000010_gene2320	6.118e-78	267.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,42Q40@68525|delta/epsilon subdivisions,2WKYI@28221|Deltaproteobacteria,2MA7Y@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	response regulator, receiver	-	-	-	ko:K02479	-	-	-	-	ko00000,ko02022	-	-	-	GerE,Response_reg
SX2_k127_5330949_4	1123274.KB899422_gene116	3.103e-24	119.0	COG4249@1|root,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	-	-	-	-	-	-	-	-	-	-	-	-	GUN4,Peptidase_C14
SX2_k127_5335883_0	880073.Calab_2882	0.0	1563.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,2NP08@2323|unclassified Bacteria	2|Bacteria	E	Glutamate synthase central domain	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
SX2_k127_5335883_1	398767.Glov_2226	5.226e-27	117.0	COG2050@1|root,COG2050@2|Bacteria,1N8F8@1224|Proteobacteria,42V78@68525|delta/epsilon subdivisions,2WRB4@28221|Deltaproteobacteria,43VHC@69541|Desulfuromonadales	28221|Deltaproteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
SX2_k127_5335883_2	332101.JIBU02000025_gene3193	3.76e-17	94.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
SX2_k127_5338320_0	889378.Spiaf_0246	3.337e-67	234.0	COG0332@1|root,COG0332@2|Bacteria,2J6DC@203691|Spirochaetes	203691|Spirochaetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
SX2_k127_5338320_4	880073.Calab_1679	9.875e-13	80.0	COG0347@1|root,COG0347@2|Bacteria,2NRH8@2323|unclassified Bacteria	2|Bacteria	K	Belongs to the P(II) protein family	-	-	-	ko:K02806,ko:K04752	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	P-II
SX2_k127_5338320_3	882.DVU_1630	9.99e-27	115.0	COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,42SD2@68525|delta/epsilon subdivisions,2WP7H@28221|Deltaproteobacteria,2MC5C@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2	ptsN	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
SX2_k127_5338320_2	1122919.KB905569_gene2919	8.402e-35	143.0	COG2186@1|root,COG2186@2|Bacteria,1V2TU@1239|Firmicutes,4HDHI@91061|Bacilli,26TD1@186822|Paenibacillaceae	91061|Bacilli	K	FCD	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
SX2_k127_5338320_5	1144319.PMI16_00151	7.976e-05	50.0	COG0662@1|root,COG0662@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	-	-	5.3.3.19	ko:K19547	ko01130,map01130	M00787	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Cupin_2,HATPase_c,His_kinase,PocR
SX2_k127_5338320_1	1460634.JCM19037_344	2.158e-52	195.0	COG4821@1|root,COG4821@2|Bacteria,1TQS7@1239|Firmicutes,4HCR4@91061|Bacilli	91061|Bacilli	S	protein containing SIS (Sugar ISomerase) phosphosugar binding domain	-	-	-	-	-	-	-	-	-	-	-	-	SIS_2
SX2_k127_5338320_6	1343740.M271_47595	0.0004055	49.0	COG1653@1|root,COG1653@2|Bacteria,2GM4E@201174|Actinobacteria	201174|Actinobacteria	G	ABC transporter substrate-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
SX2_k127_5342399_8	573413.Spirs_0323	3.149e-31	142.0	COG0597@1|root,COG0597@2|Bacteria,2J7QV@203691|Spirochaetes	203691|Spirochaetes	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
SX2_k127_5342399_1	1480694.DC28_04730	6.517e-137	460.0	COG2211@1|root,COG2211@2|Bacteria,2J6P4@203691|Spirochaetes	203691|Spirochaetes	G	transporter	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX2_k127_5342399_4	1480694.DC28_04735	1.078e-82	306.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5342399_0	697281.Mahau_1317	5.546e-166	531.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,42FF9@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SX2_k127_5342399_3	1047013.AQSP01000105_gene1454	1.707e-83	303.0	COG2086@1|root,COG2086@2|Bacteria,2NP4J@2323|unclassified Bacteria	2|Bacteria	C	Electron transfer flavoprotein	etfB	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016020,GO:0016491,GO:0022900,GO:0030312,GO:0040007,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
SX2_k127_5342399_2	459349.CLOAM1482	1.272e-125	414.0	COG2025@1|root,COG2025@2|Bacteria,2NNR6@2323|unclassified Bacteria	2|Bacteria	C	Electron transfer flavoprotein	fixB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575	1.3.1.108	ko:K03522,ko:K22432	-	-	-	-	ko00000,ko01000,ko04147	-	-	iAF987.Gmet_2066,iAF987.Gmet_2257	ETF,ETF_alpha,Fer4
SX2_k127_5342399_7	886293.Sinac_6637	4.929e-59	222.0	COG1163@1|root,COG1163@2|Bacteria,2IWYP@203682|Planctomycetes	203682|Planctomycetes	S	TGS domain	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,TGS
SX2_k127_5342399_6	1123368.AUIS01000006_gene566	5.817e-64	236.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2NDJD@225057|Acidithiobacillales	225057|Acidithiobacillales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_4,Response_reg
SX2_k127_5342399_5	545695.TREAZ_3613	3.897e-69	260.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
SX2_k127_5342399_9	555079.Toce_2132	1.743e-17	91.0	COG2119@1|root,COG2119@2|Bacteria,1UR7U@1239|Firmicutes,24QEI@186801|Clostridia,42GXZ@68295|Thermoanaerobacterales	186801|Clostridia	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
SX2_k127_535093_6	1480694.DC28_14730	1.279e-43	164.0	COG1963@1|root,COG1963@2|Bacteria,2J7WX@203691|Spirochaetes	203691|Spirochaetes	S	Divergent PAP2 family	-	-	-	ko:K09775	-	-	-	-	ko00000	-	-	-	DUF212
SX2_k127_535093_0	1047013.AQSP01000138_gene1035	4.621e-131	434.0	COG1032@1|root,COG1032@2|Bacteria,2NQU0@2323|unclassified Bacteria	2|Bacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
SX2_k127_535093_5	1123274.KB899415_gene2516	1.137e-51	209.0	COG0714@1|root,COG1302@1|root,COG0714@2|Bacteria,COG1302@2|Bacteria,2J6I6@203691|Spirochaetes	203691|Spirochaetes	S	Associated with various cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_535093_3	1307761.L21SP2_0814	4.744e-76	270.0	COG0457@1|root,COG0457@2|Bacteria,2J6MJ@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF1570
SX2_k127_535093_4	1125725.HMPREF1325_0384	2.607e-72	258.0	COG0617@1|root,COG0617@2|Bacteria,2J5VH@203691|Spirochaetes	203691|Spirochaetes	H	Belongs to the tRNA nucleotidyltransferase poly(A) polymerase family	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd
SX2_k127_535093_2	483219.LILAB_26910	2.731e-86	299.0	COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,42PYX@68525|delta/epsilon subdivisions,2WKSE@28221|Deltaproteobacteria,2YUVH@29|Myxococcales	28221|Deltaproteobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_535093_1	545694.TREPR_2696	4.123e-87	299.0	COG0124@1|root,COG0124@2|Bacteria,2J5DX@203691|Spirochaetes	203691|Spirochaetes	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
SX2_k127_5351021_4	357808.RoseRS_3061	6.022e-81	285.0	COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,2GBT4@200795|Chloroflexi,376J7@32061|Chloroflexia	32061|Chloroflexia	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4
SX2_k127_5351021_5	391625.PPSIR1_23399	1.868e-76	287.0	COG4191@1|root,COG4191@2|Bacteria,1R609@1224|Proteobacteria,42MTJ@68525|delta/epsilon subdivisions,2WJYM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	COG0515 Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Pkinase
SX2_k127_5351021_19	1348663.KCH_63580	0.0003287	54.0	COG0125@1|root,COG0125@2|Bacteria,2IGMW@201174|Actinobacteria	201174|Actinobacteria	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5351021_1	1123508.JH636440_gene2608	4.604e-106	381.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,HATPase_c,HisKA,PAS_9,Response_reg
SX2_k127_5351021_10	383372.Rcas_2664	5.811e-44	164.0	COG0745@1|root,COG0745@2|Bacteria,2G94Y@200795|Chloroflexi,377G3@32061|Chloroflexia	32061|Chloroflexia	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
SX2_k127_5351021_3	926569.ANT_00060	8.1e-82	289.0	COG2202@1|root,COG2203@1|root,COG3437@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3437@2|Bacteria,2G7KX@200795|Chloroflexi	2|Bacteria	T	HD domain	rsbP	-	3.1.3.3	ko:K02660,ko:K07315,ko:K07814,ko:K17763	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko01000,ko02022,ko02035,ko02044,ko03021	-	-	-	GAF,GAF_2,GGDEF,HATPase_c,HD,HD_5,HWE_HK,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,STAS,SpoIIE
SX2_k127_5351021_11	530564.Psta_3315	5.522e-42	175.0	COG0840@1|root,COG2202@1|root,COG0840@2|Bacteria,COG2202@2|Bacteria,2IXQA@203682|Planctomycetes	203682|Planctomycetes	NT	Methyl-accepting chemotaxis protein (MCP) signaling domain	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal,PAS_4,PAS_9
SX2_k127_5351021_16	266835.14021879	1.122e-19	106.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_16,TPR_4,TPR_8,TolB_N,Trans_reg_C
SX2_k127_5351021_9	596151.DesfrDRAFT_0237	1.119e-48	179.0	COG0835@1|root,COG0835@2|Bacteria,1RG4A@1224|Proteobacteria,43AIK@68525|delta/epsilon subdivisions,2X5YT@28221|Deltaproteobacteria,2MGWV@213115|Desulfovibrionales	28221|Deltaproteobacteria	NT	Two component signalling adaptor domain	cheW64H-1	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
SX2_k127_5351021_7	1198114.AciX9_2149	1.17e-63	232.0	COG3437@1|root,COG3437@2|Bacteria,3Y2TI@57723|Acidobacteria,2JHKC@204432|Acidobacteriia	204432|Acidobacteriia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_5,Response_reg
SX2_k127_5351021_18	1123274.KB899412_gene1513	5.275e-08	62.0	2AMU2@1|root,31CQK@2|Bacteria,2J8GC@203691|Spirochaetes	203691|Spirochaetes	S	Late competence development protein ComFB	-	-	-	ko:K02241	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	ComFB
SX2_k127_5351021_6	477641.MODMU_5517	3.707e-74	274.0	COG2201@1|root,COG2201@2|Bacteria,2GMBC@201174|Actinobacteria,4ES6U@85013|Frankiales	201174|Actinobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
SX2_k127_5351021_8	1123367.C666_16120	1.123e-50	197.0	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,2VKFS@28216|Betaproteobacteria,2KVRQ@206389|Rhodocyclales	206389|Rhodocyclales	H	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
SX2_k127_5351021_15	1345697.M493_06320	6.367e-26	114.0	COG1871@1|root,COG1871@2|Bacteria,1V70X@1239|Firmicutes,4HIVG@91061|Bacilli,1WEA3@129337|Geobacillus	91061|Bacilli	NT	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis	cheD	-	3.5.1.44	ko:K03411	ko02030,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheD
SX2_k127_5351021_0	429009.Adeg_0244	3.358e-109	388.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1TPMS@1239|Firmicutes,24858@186801|Clostridia,42END@68295|Thermoanaerobacterales	186801|Clostridia	T	Signal transducing histidine kinase, homodimeric	cheA3	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
SX2_k127_5351021_17	1345695.CLSA_c20470	5.972e-13	79.0	COG1406@1|root,COG1406@2|Bacteria,1VD18@1239|Firmicutes,24HMR@186801|Clostridia,36ING@31979|Clostridiaceae	186801|Clostridia	N	Chemotaxis protein CheX	-	-	-	ko:K03409	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheX
SX2_k127_5351021_12	335541.Swol_0863	1.801e-40	152.0	COG2204@1|root,COG2204@2|Bacteria,1UHXE@1239|Firmicutes,25E6A@186801|Clostridia,42JXC@68298|Syntrophomonadaceae	186801|Clostridia	T	cheY-homologous receiver domain	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
SX2_k127_5351021_2	357808.RoseRS_3061	2.509e-83	305.0	COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,2GBT4@200795|Chloroflexi,376J7@32061|Chloroflexia	32061|Chloroflexia	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4
SX2_k127_5351021_13	383372.Rcas_2664	4.768e-33	133.0	COG0745@1|root,COG0745@2|Bacteria,2G94Y@200795|Chloroflexi,377G3@32061|Chloroflexia	32061|Chloroflexia	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
SX2_k127_5351021_14	1122236.KB905141_gene1625	2.686e-28	117.0	COG0745@1|root,COG0745@2|Bacteria,1RD7E@1224|Proteobacteria,2VVWD@28216|Betaproteobacteria,2KPBH@206350|Nitrosomonadales	206350|Nitrosomonadales	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
SX2_k127_5363410_1	1047013.AQSP01000134_gene1371	5.255e-81	285.0	COG0531@1|root,COG0589@1|root,COG0531@2|Bacteria,COG0589@2|Bacteria,2NS54@2323|unclassified Bacteria	2|Bacteria	E	Amino acid permease	ybaT	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009268,GO:0009628,GO:0010035,GO:0010038,GO:0016020,GO:0042221,GO:0044464,GO:0046688,GO:0050896,GO:0071944,GO:0097501,GO:1990169	-	ko:K07076,ko:K11932,ko:K16263	-	-	-	-	ko00000,ko02000	2.A.3.13	-	-	AA_permease_2,Usp
SX2_k127_5363410_2	1480694.DC28_15190	3.935e-62	238.0	COG0569@1|root,COG0569@2|Bacteria,2J7SR@203691|Spirochaetes	203691|Spirochaetes	C	TrkA-N domain	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
SX2_k127_5363410_0	1480694.DC28_15195	1.285e-102	349.0	COG0168@1|root,COG0168@2|Bacteria,2J5NF@203691|Spirochaetes	203691|Spirochaetes	P	Potassium uptake protein, TrkH family	ntpJ	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
SX2_k127_5364449_1	1183438.GKIL_2037	4.497e-140	457.0	COG2217@1|root,COG2217@2|Bacteria,1G11M@1117|Cyanobacteria	1117|Cyanobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,HMA,Hydrolase
SX2_k127_5364449_2	1499967.BAYZ01000116_gene3146	5.771e-38	149.0	2EEHS@1|root,338BM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5364449_0	1304880.JAGB01000001_gene561	1.589e-313	987.0	COG0383@1|root,COG0383@2|Bacteria,1V0Q3@1239|Firmicutes,24AMV@186801|Clostridia	186801|Clostridia	G	Alpha mannosidase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
SX2_k127_5364449_3	1232410.KI421428_gene1072	4.994e-24	113.0	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,42S1J@68525|delta/epsilon subdivisions,2WP2S@28221|Deltaproteobacteria,43SI8@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
SX2_k127_5364449_4	324602.Caur_2704	4.033e-15	79.0	COG1597@1|root,COG1597@2|Bacteria,2G6UK@200795|Chloroflexi,375KA@32061|Chloroflexia	32061|Chloroflexia	I	PFAM diacylglycerol kinase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
SX2_k127_5373766_5	926550.CLDAP_34860	8.723e-98	330.0	COG0508@1|root,COG0508@2|Bacteria	2|Bacteria	C	S-acyltransferase activity	pdhC	-	2.3.1.12,2.3.1.61	ko:K00627,ko:K00658	ko00010,ko00020,ko00310,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00310,map00620,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032,M00307	R00209,R02569,R02570,R02571,R08549	RC00004,RC02727,RC02742,RC02833,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
SX2_k127_5373766_3	1499967.BAYZ01000090_gene4960	5.523e-137	450.0	COG1249@1|root,COG1249@2|Bacteria,2NNTI@2323|unclassified Bacteria	2|Bacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
SX2_k127_5373766_0	1499967.BAYZ01000090_gene4959	0.0	1176.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,2NNT2@2323|unclassified Bacteria	2|Bacteria	C	Transketolase, pyrimidine binding domain	pdhA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00162,ko:K00167,ko:K11381	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
SX2_k127_5373766_1	497964.CfE428DRAFT_0391	1.499e-175	567.0	COG1904@1|root,COG1904@2|Bacteria,46SH8@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Glucuronate isomerase	uxaC	-	5.3.1.12	ko:K01812	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	UxaC
SX2_k127_5373766_2	234267.Acid_6969	3.69e-162	520.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX2_k127_5373766_4	1121439.dsat_1867	2.801e-126	421.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,42N9Z@68525|delta/epsilon subdivisions,2WIKQ@28221|Deltaproteobacteria,2M9HW@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	PFAM 6-phosphogluconate dehydrogenase NAD-binding	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
SX2_k127_5373766_6	1171373.PACID_26600	3.496e-71	270.0	COG0153@1|root,COG0153@2|Bacteria,2H2AH@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the GHMP kinase family	-	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
SX2_k127_5373766_7	656519.Halsa_1357	1.079e-27	124.0	COG4206@1|root,COG4206@2|Bacteria,1V287@1239|Firmicutes,24SUD@186801|Clostridia,3WB9E@53433|Halanaerobiales	186801|Clostridia	H	TonB-dependent Receptor Plug	-	-	-	ko:K02014,ko:K16089	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.1,1.B.14.10	-	-	Plug,TonB_dep_Rec
SX2_k127_5375981_1	1500890.JQNL01000001_gene3751	3.826e-31	124.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,1RMWK@1236|Gammaproteobacteria,1X2X9@135614|Xanthomonadales	135614|Xanthomonadales	V	Part of the ABC transporter complex LolCDE involved in the translocation of	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
SX2_k127_5375981_0	497964.CfE428DRAFT_4943	4.699e-159	544.0	COG0577@1|root,COG0577@2|Bacteria,46U6N@74201|Verrucomicrobia	74201|Verrucomicrobia	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
SX2_k127_5375981_2	1123508.JH636443_gene4671	1.69e-13	74.0	COG1520@1|root,COG1520@2|Bacteria,2IXST@203682|Planctomycetes	203682|Planctomycetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
SX2_k127_5380762_2	867845.KI911784_gene2133	1.302e-26	111.0	COG0082@1|root,COG0082@2|Bacteria,2G645@200795|Chloroflexi,37555@32061|Chloroflexia	32061|Chloroflexia	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
SX2_k127_5380762_0	471853.Bcav_3352	3.51e-65	237.0	COG1820@1|root,COG1820@2|Bacteria,2HKTU@201174|Actinobacteria	201174|Actinobacteria	G	Amidohydrolase family	-	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
SX2_k127_5380762_1	1499967.BAYZ01000097_gene4339	2.968e-61	224.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX2_k127_5380762_3	1133850.SHJG_8340	3.898e-13	74.0	COG1175@1|root,COG1175@2|Bacteria,2GJGB@201174|Actinobacteria	201174|Actinobacteria	G	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX2_k127_5399473_13	1232449.BAHV02000008_gene670	9.257e-16	81.0	COG0176@1|root,COG0176@2|Bacteria,1U9RA@1239|Firmicutes,24DCI@186801|Clostridia	186801|Clostridia	H	PFAM Transaldolase	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
SX2_k127_5399473_4	573413.Spirs_0322	1.255e-76	264.0	COG0327@1|root,COG0327@2|Bacteria,2J6QQ@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM dinuclear metal center protein, YbgI SA1388 family	-	-	-	-	-	-	-	-	-	-	-	-	NIF3
SX2_k127_5399473_1	1122915.AUGY01000068_gene6768	1.201e-136	460.0	COG1680@1|root,COG1680@2|Bacteria,1UUHI@1239|Firmicutes,4HNEC@91061|Bacilli,26QY8@186822|Paenibacillaceae	91061|Bacilli	V	beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SX2_k127_5399473_7	871968.DESME_05000	1.598e-52	197.0	COG0204@1|root,COG0204@2|Bacteria,1V5X9@1239|Firmicutes,24X01@186801|Clostridia	186801|Clostridia	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5399473_5	871968.DESME_04995	7.399e-70	244.0	COG0463@1|root,COG0463@2|Bacteria,1TQ8C@1239|Firmicutes,248MK@186801|Clostridia,2633W@186807|Peptococcaceae	186801|Clostridia	M	glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,GtrA
SX2_k127_5399473_0	759914.BP951000_0406	3.4e-180	569.0	COG0057@1|root,COG0057@2|Bacteria,2J5AD@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
SX2_k127_5399473_10	765952.PUV_04810	4.164e-28	119.0	COG1762@1|root,COG1762@2|Bacteria,2JG5P@204428|Chlamydiae	204428|Chlamydiae	G	PTS system, IIa	ptsN_1	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
SX2_k127_5399473_2	545694.TREPR_1221	2.112e-122	402.0	COG2089@1|root,COG2089@2|Bacteria,2J662@203691|Spirochaetes	203691|Spirochaetes	M	Sialic acid synthase	-	-	2.5.1.56	ko:K01654	ko00520,ko01100,map00520,map01100	-	R01804,R04435	RC00159	ko00000,ko00001,ko01000	-	-	-	NeuB,SAF
SX2_k127_5399473_8	512565.AMIS_43060	2.628e-46	171.0	COG3877@1|root,COG3877@2|Bacteria,2IJTS@201174|Actinobacteria,4DDM4@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF2089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2089
SX2_k127_5399473_12	311424.DhcVS_526	3.348e-21	102.0	2DRM1@1|root,33C8J@2|Bacteria,2GATW@200795|Chloroflexi,34DBZ@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5399473_6	357808.RoseRS_4475	4.974e-56	211.0	COG3836@1|root,COG3836@2|Bacteria,2G925@200795|Chloroflexi,377KS@32061|Chloroflexia	32061|Chloroflexia	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.2.20,4.1.2.52	ko:K01630,ko:K02510	ko00053,ko00350,ko01120,map00053,map00350,map01120	-	R01645,R01647,R02754,R03277	RC00307,RC00435,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
SX2_k127_5399473_3	215803.DB30_8211	7.359e-86	309.0	COG3384@1|root,COG3384@2|Bacteria,1MXJZ@1224|Proteobacteria,42Q1N@68525|delta/epsilon subdivisions,2WK3A@28221|Deltaproteobacteria,2YU8P@29|Myxococcales	28221|Deltaproteobacteria	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	ygiD	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
SX2_k127_5399473_11	1463845.JOIG01000005_gene3263	5.776e-27	128.0	COG1172@1|root,COG1172@2|Bacteria,2GJDW@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
SX2_k127_5399473_9	97139.C824_01933	3.436e-32	146.0	COG1879@1|root,COG1879@2|Bacteria,1V607@1239|Firmicutes,24G4K@186801|Clostridia,36S34@31979|Clostridiaceae	186801|Clostridia	G	Periplasmic binding proteins and sugar binding domain of LacI family	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
SX2_k127_5407530_0	667014.Thein_1357	3.462e-76	269.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,2GGV4@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	I	CoA enzyme activase uncharacterised domain (DUF2229)	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
SX2_k127_5407530_1	525904.Tter_0922	5.08e-53	199.0	COG2120@1|root,COG2120@2|Bacteria,2NPAV@2323|unclassified Bacteria	2|Bacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
SX2_k127_5407530_2	744872.Spica_0843	4.158e-24	112.0	COG3393@1|root,COG3393@2|Bacteria,2J84J@203691|Spirochaetes	203691|Spirochaetes	S	Acetyltransferase GNAT family	-	-	-	ko:K06976	-	-	-	-	ko00000	-	-	-	Acetyltransf_1,Acetyltransf_10,FR47
SX2_k127_5414002_4	744872.Spica_0573	8.43e-09	61.0	COG0707@1|root,COG0707@2|Bacteria,2J9T2@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5414002_0	1307761.L21SP2_1614	2.163e-148	481.0	COG0141@1|root,COG0141@2|Bacteria,2J5QF@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
SX2_k127_5414002_1	1128421.JAGA01000002_gene1982	2.835e-60	219.0	COG2723@1|root,COG2723@2|Bacteria,2NPRZ@2323|unclassified Bacteria	2|Bacteria	G	Glycosyl hydrolase family 1	bglA1	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
SX2_k127_5414002_2	243233.MCA1578	1.024e-20	93.0	COG2723@1|root,COG2723@2|Bacteria,1MWG6@1224|Proteobacteria,1RMM2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 1 family	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
SX2_k127_5414002_3	1231190.NA8A_19193	8.217e-09	56.0	COG0329@1|root,COG0329@2|Bacteria,1MWMN@1224|Proteobacteria,2TSAF@28211|Alphaproteobacteria,43JCG@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EM	Dihydrodipicolinate synthetase family	MA20_28770	-	-	-	-	-	-	-	-	-	-	-	DHDPS
SX2_k127_5414432_7	1415775.U729_75	6.727e-06	48.0	COG2201@1|root,COG2201@2|Bacteria,1V3IU@1239|Firmicutes,24HJF@186801|Clostridia,36IRR@31979|Clostridiaceae	186801|Clostridia	NT	Chemotaxis protein cheY	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
SX2_k127_5414432_0	1307761.L21SP2_0826	8.4e-149	479.0	COG1186@1|root,COG1186@2|Bacteria,2J5QR@203691|Spirochaetes	203691|Spirochaetes	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
SX2_k127_5414432_5	545695.TREAZ_0007	1.723e-20	96.0	2FK3B@1|root,34BRF@2|Bacteria,2J8AH@203691|Spirochaetes	203691|Spirochaetes	S	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette	-	-	-	ko:K09951	-	-	-	-	ko00000,ko02048	-	-	-	CRISPR_Cas2
SX2_k127_5414432_4	545695.TREAZ_0006	3.499e-21	105.0	COG1729@1|root,COG1729@2|Bacteria,2J6ZY@203691|Spirochaetes	203691|Spirochaetes	S	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5414432_1	573413.Spirs_1915	2.971e-132	447.0	COG1449@1|root,COG1449@2|Bacteria,2J5C8@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 57 family	-	-	2.4.1.25	ko:K22451	ko00500,map00500	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH57	-	DUF1925,DUF1926,Glyco_hydro_57
SX2_k127_5414432_6	1480694.DC28_06690	6.178e-12	78.0	COG4657@1|root,COG4657@2|Bacteria,2J5ES@203691|Spirochaetes	203691|Spirochaetes	C	Part of a membrane complex involved in electron transport	rnfA	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
SX2_k127_5414432_3	573413.Spirs_1910	2.363e-74	267.0	COG4658@1|root,COG4658@2|Bacteria,2J639@203691|Spirochaetes	203691|Spirochaetes	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
SX2_k127_5414432_2	573413.Spirs_1909	2.072e-74	267.0	COG4656@1|root,COG4656@2|Bacteria,2J5TG@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily	rnfC	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_8,RnfC_N,SLBB
SX2_k127_5421032_5	744872.Spica_0638	5.369e-19	94.0	2ARTN@1|root,31H54@2|Bacteria,2J9BP@203691|Spirochaetes	203691|Spirochaetes	N	SPTR Polysaccharide Lyase Family 1 modular protein with two candidate pectate lyase domains	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5421032_3	1499967.BAYZ01000057_gene4737	3.194e-76	285.0	COG0673@1|root,COG0673@2|Bacteria,2NRVS@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX2_k127_5421032_1	631454.N177_0159	6.026e-186	612.0	COG0028@1|root,COG0028@2|Bacteria,1R743@1224|Proteobacteria,2U4KA@28211|Alphaproteobacteria,1JPSX@119043|Rhodobiaceae	28211|Alphaproteobacteria	EH	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	3.7.1.22	ko:K03336	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08603	RC02331	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
SX2_k127_5421032_4	1410620.SHLA_25c000630	1.649e-51	191.0	COG1414@1|root,COG1414@2|Bacteria,1MUNW@1224|Proteobacteria,2TSY8@28211|Alphaproteobacteria,4BCGY@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix isocitrate lyase regulation	-	-	-	ko:K13641,ko:K19333	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR,SGL
SX2_k127_5421032_6	416591.Tlet_0553	9.938e-18	90.0	2E32K@1|root,32Y2U@2|Bacteria,2GDGH@200918|Thermotogae	200918|Thermotogae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5421032_0	903818.KI912269_gene336	1.576e-278	870.0	COG1048@1|root,COG1048@2|Bacteria,3Y4NH@57723|Acidobacteria	57723|Acidobacteria	C	Aconitase family (aconitate hydratase)	-	-	-	-	-	-	-	-	-	-	-	-	Aconitase,Aconitase_C
SX2_k127_5421032_2	1128398.Curi_c28890	3.171e-164	533.0	COG0538@1|root,COG0538@2|Bacteria,1TSKB@1239|Firmicutes,247KX@186801|Clostridia,267TT@186813|unclassified Clostridiales	186801|Clostridia	C	Isocitrate/isopropylmalate dehydrogenase	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
SX2_k127_5421395_3	96561.Dole_2961	3.807e-61	215.0	COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,42MK9@68525|delta/epsilon subdivisions,2WJ1C@28221|Deltaproteobacteria,2MIP5@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM PhoH-like protein	phoH1	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
SX2_k127_5421395_1	1123274.KB899407_gene241	6.452e-71	266.0	COG1301@1|root,COG1301@2|Bacteria,2J6P3@203691|Spirochaetes	203691|Spirochaetes	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
SX2_k127_5421395_0	665571.STHERM_c01020	5.822e-94	336.0	COG1210@1|root,COG1210@2|Bacteria,2J70S@203691|Spirochaetes	203691|Spirochaetes	M	Nucleotidyl transferase	gtaB	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
SX2_k127_5421395_10	1382356.JQMP01000001_gene978	3.036e-31	135.0	COG0337@1|root,COG0703@1|root,COG0337@2|Bacteria,COG0703@2|Bacteria,2G5K8@200795|Chloroflexi,27XTZ@189775|Thermomicrobia	189775|Thermomicrobia	H	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
SX2_k127_5421395_4	1123274.KB899438_gene649	6.199e-60	223.0	COG0106@1|root,COG0106@2|Bacteria,2J8GX@203691|Spirochaetes	203691|Spirochaetes	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
SX2_k127_5421395_12	573413.Spirs_1642	1.079e-27	122.0	COG1762@1|root,COG1762@2|Bacteria	2|Bacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system	-	-	2.7.1.194,2.7.1.202,2.7.13.3	ko:K02768,ko:K02769,ko:K02770,ko:K02806,ko:K02821,ko:K07646	ko00051,ko00053,ko01100,ko01120,ko02020,ko02060,map00051,map00053,map01100,map01120,map02020,map02060	M00273,M00283,M00454,M00550	R03232,R07671	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02022	4.A.2.1,4.A.7.1	-	-	KdpD,Na_H_Exchanger,PTS_EIIA_2
SX2_k127_5421395_14	335541.Swol_0083	1.468e-07	61.0	COG0776@1|root,COG0776@2|Bacteria,1V9XQ@1239|Firmicutes,24MM0@186801|Clostridia,42K0V@68298|Syntrophomonadaceae	186801|Clostridia	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hup	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
SX2_k127_5421395_13	756499.Desde_1822	1.413e-23	113.0	COG0494@1|root,COG0494@2|Bacteria,1V6ET@1239|Firmicutes,25EBI@186801|Clostridia,267A9@186807|Peptococcaceae	186801|Clostridia	L	Belongs to the Nudix hydrolase family	mutT	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
SX2_k127_5421395_5	765420.OSCT_1939	1.737e-56	211.0	COG0177@1|root,COG0177@2|Bacteria,2G6A1@200795|Chloroflexi,375YQ@32061|Chloroflexia	32061|Chloroflexia	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
SX2_k127_5421395_7	243365.CV_1259	9.229e-47	183.0	COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,2VR7F@28216|Betaproteobacteria,2KQVT@206351|Neisseriales	206351|Neisseriales	H	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
SX2_k127_5421395_9	665571.STHERM_c18980	1.07e-43	169.0	COG1211@1|root,COG1211@2|Bacteria,2J6JT@203691|Spirochaetes	203691|Spirochaetes	I	Belongs to the IspD TarI cytidylyltransferase family. IspD subfamily	ispD	-	2.7.7.60,4.6.1.12	ko:K00991,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
SX2_k127_5421395_2	545694.TREPR_1023	1.61e-65	233.0	COG1329@1|root,COG1329@2|Bacteria,2J7TP@203691|Spirochaetes	203691|Spirochaetes	K	Transcription factor	-	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
SX2_k127_5421395_8	665571.STHERM_c18960	3.85e-45	174.0	COG0398@1|root,COG0398@2|Bacteria,2J8MX@203691|Spirochaetes	203691|Spirochaetes	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
SX2_k127_5421395_6	688269.Theth_1581	2.108e-48	177.0	COG0426@1|root,COG0426@2|Bacteria,2GCAS@200918|Thermotogae	200918|Thermotogae	C	flavodoxin nitric oxide synthase	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Lactamase_B
SX2_k127_5432453_9	1227349.C170_25962	3.802e-15	76.0	COG1486@1|root,COG1486@2|Bacteria,1TQ9I@1239|Firmicutes,4HCGH@91061|Bacilli,26V5X@186822|Paenibacillaceae	91061|Bacilli	G	Family 4 glycosyl hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
SX2_k127_5432453_8	1304284.L21TH_1859	1.719e-16	89.0	COG1486@1|root,COG1486@2|Bacteria,1TQ9I@1239|Firmicutes,24995@186801|Clostridia,36EXF@31979|Clostridiaceae	186801|Clostridia	G	family 4	celF	-	3.2.1.86	ko:K01222	ko00010,ko00500,map00010,map00500	-	R00839,R05133,R05134	RC00049,RC00171,RC00714	ko00000,ko00001,ko01000	-	GT4	-	Glyco_hydro_4,Glyco_hydro_4C
SX2_k127_5432453_1	1033743.CAES01000046_gene277	7.542e-119	401.0	COG0673@1|root,COG0673@2|Bacteria,1UWP1@1239|Firmicutes,4I6SZ@91061|Bacilli,26USD@186822|Paenibacillaceae	91061|Bacilli	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX2_k127_5432453_3	1304880.JAGB01000001_gene863	2.728e-95	331.0	COG0673@1|root,COG0673@2|Bacteria,1VC8Q@1239|Firmicutes,24UI7@186801|Clostridia	186801|Clostridia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
SX2_k127_5432453_0	357808.RoseRS_2242	1.445e-133	439.0	COG0477@1|root,COG2814@2|Bacteria,2G71K@200795|Chloroflexi	200795|Chloroflexi	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX2_k127_5432453_4	1122947.FR7_0445	3.196e-89	306.0	COG1735@1|root,COG1735@2|Bacteria,1TS8I@1239|Firmicutes	1239|Firmicutes	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	ko:K07048	-	-	-	-	ko00000	-	-	-	PTE
SX2_k127_5432453_5	515635.Dtur_0462	9.452e-85	308.0	COG2723@1|root,COG2723@2|Bacteria	2|Bacteria	G	beta-glucosidase activity	bglB	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
SX2_k127_5432453_7	1121459.AQXE01000003_gene1181	2.682e-57	223.0	COG1572@1|root,COG1572@2|Bacteria,1PGI2@1224|Proteobacteria,4378M@68525|delta/epsilon subdivisions,2X2BD@28221|Deltaproteobacteria,2MFJP@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4091)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4091
SX2_k127_5432453_6	479435.Kfla_4578	4.032e-71	253.0	COG0584@1|root,COG0584@2|Bacteria,2GIY5@201174|Actinobacteria,4DP0C@85009|Propionibacteriales	201174|Actinobacteria	C	Glycerophosphoryl diester phosphodiesterase family	-	-	-	-	-	-	-	-	-	-	-	-	GDPD,GDPD_2
SX2_k127_5432453_2	96561.Dole_0644	3.897e-112	374.0	COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,42MFI@68525|delta/epsilon subdivisions,2WKXD@28221|Deltaproteobacteria,2MM6V@213118|Desulfobacterales	28221|Deltaproteobacteria	S	AAA domain	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
SX2_k127_5434967_0	861299.J421_3743	7.641e-06	58.0	COG2805@1|root,COG2805@2|Bacteria,1ZSTM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
SX2_k127_5454236_1	1408423.JHYA01000011_gene1224	1.137e-34	136.0	COG1694@1|root,COG3956@2|Bacteria,1TPK1@1239|Firmicutes,4H24I@909932|Negativicutes	909932|Negativicutes	S	MazG family	mazG	-	-	ko:K02499	-	-	-	-	ko00000,ko03036	-	-	-	MazG,TP_methylase
SX2_k127_5454236_0	573413.Spirs_2070	6.58e-194	629.0	COG1032@1|root,COG5011@1|root,COG1032@2|Bacteria,COG5011@2|Bacteria,2J5YW@203691|Spirochaetes	203691|Spirochaetes	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344,Radical_SAM
SX2_k127_5459887_3	530564.Psta_3105	5.783e-88	297.0	COG2321@1|root,COG2321@2|Bacteria,2IZ1Y@203682|Planctomycetes	203682|Planctomycetes	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
SX2_k127_5459887_15	760568.Desku_2752	0.0004053	53.0	COG0243@1|root,COG0243@2|Bacteria,1TPZG@1239|Firmicutes,247JV@186801|Clostridia,2605J@186807|Peptococcaceae	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.5,1.8.5.6	ko:K08352,ko:K21307	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R10149,R11487	RC00168,RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
SX2_k127_5459887_1	305900.GV64_23840	1.541e-94	319.0	COG3717@1|root,COG3717@2|Bacteria,1MU9D@1224|Proteobacteria,1RPDB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate	kduI	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005975,GO:0005996,GO:0006063,GO:0006064,GO:0006082,GO:0008150,GO:0008152,GO:0008697,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016853,GO:0016860,GO:0016861,GO:0019585,GO:0019586,GO:0019698,GO:0019752,GO:0032787,GO:0042802,GO:0042839,GO:0042840,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046396,GO:0046397,GO:0046872,GO:0071704,GO:0072329,GO:1901575	5.3.1.17	ko:K01815	ko00040,map00040	-	R04383	RC00541	ko00000,ko00001,ko01000	-	-	-	KduI
SX2_k127_5459887_5	1297617.JPJD01000025_gene1193	3.727e-55	203.0	COG1237@1|root,COG1237@2|Bacteria,1UWI6@1239|Firmicutes,247K3@186801|Clostridia,2698R@186813|unclassified Clostridiales	186801|Clostridia	S	Metallo-beta-lactamase superfamily	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
SX2_k127_5459887_9	1463825.JNXC01000055_gene1082	4.154e-38	161.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
SX2_k127_5459887_11	189753.AXAS01000002_gene5095	1.944e-14	79.0	2ECBK@1|root,3369Z@2|Bacteria,1N60M@1224|Proteobacteria,2UCCX@28211|Alphaproteobacteria,3K0PX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5459887_8	1116369.KB890025_gene5094	2.775e-45	178.0	COG0111@1|root,COG2055@1|root,COG0111@2|Bacteria,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,2TR37@28211|Alphaproteobacteria,43NZX@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Belongs to the LDH2 MDH2 oxidoreductase family	-	-	1.1.1.350	ko:K00073	ko00230,ko01120,map00230,map01120	-	R02935,R02936	RC00169	ko00000,ko00001,ko01000	-	-	-	Ldh_2
SX2_k127_5459887_12	234267.Acid_6615	5.935e-14	83.0	28KX8@1|root,2ZAD8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5459887_10	1274374.CBLK010000056_gene254	1.817e-37	160.0	COG1653@1|root,COG1653@2|Bacteria,1V5AZ@1239|Firmicutes,4HHD2@91061|Bacilli,276P0@186822|Paenibacillaceae	91061|Bacilli	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1,SBP_bac_8
SX2_k127_5459887_2	697281.Mahau_2574	1.808e-91	311.0	COG4209@1|root,COG4209@2|Bacteria,1TP33@1239|Firmicutes,247UA@186801|Clostridia	186801|Clostridia	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
SX2_k127_5459887_4	1033743.CAES01000048_gene861	1.008e-69	246.0	COG0395@1|root,COG0395@2|Bacteria,1VR6P@1239|Firmicutes,4HUME@91061|Bacilli,26QUY@186822|Paenibacillaceae	91061|Bacilli	G	binding-protein-dependent transport systems inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
SX2_k127_5459887_0	1499967.BAYZ01000017_gene6251	2.682e-164	520.0	COG0363@1|root,COG0363@2|Bacteria	2|Bacteria	G	glucosamine-6-phosphate deaminase activity	nagB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	3.1.1.31,3.5.99.6	ko:K01057,ko:K02564	ko00030,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00520,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R00765,R02035	RC00163,RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
SX2_k127_5459887_6	1125863.JAFN01000001_gene2321	1.699e-54	212.0	COG0778@1|root,COG0778@2|Bacteria,1RBBW@1224|Proteobacteria,42QWC@68525|delta/epsilon subdivisions,2WMVU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SX2_k127_5459887_7	867845.KI911784_gene371	5.245e-52	206.0	COG1131@1|root,COG1131@2|Bacteria,2G5PC@200795|Chloroflexi,376BU@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX2_k127_5459887_14	1041139.KB902602_gene151	3.515e-05	56.0	2CH5W@1|root,3020J@2|Bacteria,1Q73P@1224|Proteobacteria,2VD7X@28211|Alphaproteobacteria,4BIB8@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5476491_1	1123274.KB899428_gene1849	7.439e-35	138.0	COG1135@1|root,COG1135@2|Bacteria,2J7XY@203691|Spirochaetes	203691|Spirochaetes	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
SX2_k127_5476491_0	1123274.KB899428_gene1848	1.07e-77	274.0	COG1463@1|root,COG1463@2|Bacteria,2J7MR@203691|Spirochaetes	203691|Spirochaetes	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
SX2_k127_5476491_3	596151.DesfrDRAFT_2255	1.036e-08	68.0	COG0457@1|root,COG0457@2|Bacteria,1N4XB@1224|Proteobacteria,43E9C@68525|delta/epsilon subdivisions,2X02Q@28221|Deltaproteobacteria,2MA28@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12
SX2_k127_5476491_2	573413.Spirs_1730	2.52e-18	95.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,2J7KD@203691|Spirochaetes	203691|Spirochaetes	M	M23 M37 peptidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23
SX2_k127_5522259_8	68219.JNXI01000010_gene5730	6.609e-18	86.0	COG5002@1|root,COG5002@2|Bacteria,2GIX7@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
SX2_k127_5522259_0	404380.Gbem_1577	0.0	1326.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,42Q75@68525|delta/epsilon subdivisions,2WMDY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DEAD DEAH box	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
SX2_k127_5522259_9	1313301.AUGC01000009_gene1041	8.667e-18	93.0	COG0501@1|root,COG0501@2|Bacteria,4NE0J@976|Bacteroidetes	976|Bacteroidetes	O	Peptidase M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
SX2_k127_5522259_5	643867.Ftrac_1681	6.241e-32	140.0	2CK4K@1|root,32QTB@2|Bacteria,4NQUN@976|Bacteroidetes,47WRQ@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4870)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4870
SX2_k127_5522259_4	643867.Ftrac_1682	1.522e-64	234.0	29X2E@1|root,30IQW@2|Bacteria,4P919@976|Bacteroidetes,47WI2@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
SX2_k127_5522259_2	1142394.PSMK_31760	1.26e-159	526.0	COG1874@1|root,COG1874@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	GHL6,Glyco_hydro_42M
SX2_k127_5522259_7	255470.cbdbA1472	1.5e-26	125.0	COG0716@1|root,COG0716@2|Bacteria,2GAZ4@200795|Chloroflexi,34DME@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5522259_1	1128421.JAGA01000001_gene2222	3.338e-167	537.0	COG1082@1|root,COG1082@2|Bacteria,2NQCG@2323|unclassified Bacteria	2|Bacteria	G	AP endonuclease family 2 C terminus	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
SX2_k127_5522259_3	404589.Anae109_1511	7.354e-82	284.0	COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,42P1M@68525|delta/epsilon subdivisions,2WKJ2@28221|Deltaproteobacteria,2Z11I@29|Myxococcales	28221|Deltaproteobacteria	M	CAAX prenyl protease N-terminal, five membrane helices	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
SX2_k127_5534737_0	1480694.DC28_00545	5.577e-116	383.0	2BFJ7@1|root,329D7@2|Bacteria,2J651@203691|Spirochaetes	203691|Spirochaetes	N	flagellar filament outer layer protein	flaA	-	-	-	-	-	-	-	-	-	-	-	FlaA
SX2_k127_5534737_1	744872.Spica_0957	1.202e-60	225.0	2F39Z@1|root,33W49@2|Bacteria,2J8PJ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5534737_3	990073.ATHU01000002_gene68	7.275e-07	61.0	COG0745@1|root,COG0745@2|Bacteria,1RDNP@1224|Proteobacteria,42RF8@68525|delta/epsilon subdivisions,2YP7F@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	KT	Chemotaxis protein cheY	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
SX2_k127_5534737_2	744872.Spica_0960	2.632e-12	74.0	COG1406@1|root,COG1406@2|Bacteria,2J7CB@203691|Spirochaetes	203691|Spirochaetes	N	Chemotaxis protein CheX	cheX	-	-	ko:K03409	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheX
SX2_k127_5544442_1	1123274.KB899418_gene2281	2.013e-67	248.0	COG5002@1|root,COG5002@2|Bacteria,2J755@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
SX2_k127_5544442_0	906968.Trebr_0803	1.448e-84	286.0	COG0745@1|root,COG0745@2|Bacteria,2J63S@203691|Spirochaetes	203691|Spirochaetes	K	Response regulator receiver domain	-	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SX2_k127_5544442_2	497964.CfE428DRAFT_3173	2.789e-26	114.0	COG0673@1|root,COG0673@2|Bacteria,46TMF@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
SX2_k127_5550946_0	1307761.L21SP2_0211	5.544e-149	478.0	COG3842@1|root,COG3842@2|Bacteria,2J5T3@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
SX2_k127_5550946_1	545694.TREPR_3045	7.456e-65	237.0	COG1653@1|root,COG1653@2|Bacteria,2J5NC@203691|Spirochaetes	203691|Spirochaetes	G	transport	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
SX2_k127_5550946_2	665571.STHERM_c02000	1.742e-63	232.0	COG1242@1|root,COG1242@2|Bacteria,2J6Y8@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM radical SAM protein, TIGR01212 family	-	-	-	ko:K07139	-	-	-	-	ko00000	-	-	-	Radical_SAM,Radical_SAM_C
SX2_k127_5550946_3	545694.TREPR_3044	4.354e-33	134.0	2AMDJ@1|root,31C90@2|Bacteria,2J6DK@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5550946_4	877418.ATWV01000004_gene1751	1.217e-17	84.0	COG0436@1|root,COG0436@2|Bacteria,2J5R0@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
SX2_k127_5551090_0	1142394.PSMK_17850	9.291e-209	669.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,Glyco_hydro_106
SX2_k127_5558065_4	1487923.DP73_12275	1.808e-23	114.0	arCOG15062@1|root,32Y8D@2|Bacteria,1VEUQ@1239|Firmicutes,24TKJ@186801|Clostridia,262D1@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PQ-loop
SX2_k127_5558065_0	1133849.O3I_007810	2.11e-61	221.0	COG2518@1|root,COG2518@2|Bacteria	2|Bacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31,TPMT
SX2_k127_5558065_2	889378.Spiaf_0238	4.178e-56	206.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SX2_k127_5558065_3	886293.Sinac_0549	7.997e-30	121.0	COG0724@1|root,COG0724@2|Bacteria,2IZPY@203682|Planctomycetes	203682|Planctomycetes	S	PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
SX2_k127_5558065_1	660470.Theba_1369	3.585e-57	203.0	COG0386@1|root,COG0386@2|Bacteria	2|Bacteria	O	Belongs to the glutathione peroxidase family	btuE	-	1.11.1.22,1.11.1.9	ko:K00432,ko:K20207	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	iJN678.slr1992	GSHPx
SX2_k127_5558065_5	1131462.DCF50_p1700	7.301e-22	103.0	COG1832@1|root,COG1832@2|Bacteria,1V7C7@1239|Firmicutes,24P0N@186801|Clostridia,2632C@186807|Peptococcaceae	186801|Clostridia	S	CoA-binding protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
SX2_k127_5579119_1	96561.Dole_2811	7.199e-27	128.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42QJF@68525|delta/epsilon subdivisions,2WJ9D@28221|Deltaproteobacteria,2MIGZ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,Response_reg
SX2_k127_5579119_0	1191523.MROS_2483	4.729e-140	492.0	COG2221@1|root,COG4191@1|root,COG4624@1|root,COG2221@2|Bacteria,COG4191@2|Bacteria,COG4624@2|Bacteria	2|Bacteria	C	iron-sulfur cluster assembly	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	FeS,Fe_hyd_lg_C,Fer4,Fer4_10,HATPase_c,HTH_8,HisKA,PAS_8,Sigma54_activat
SX2_k127_5592301_8	665571.STHERM_c16310	3.748e-23	101.0	COG0330@1|root,COG0330@2|Bacteria,2J5A8@203691|Spirochaetes	203691|Spirochaetes	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
SX2_k127_5592301_4	744872.Spica_1195	3.582e-97	332.0	COG0330@1|root,COG0330@2|Bacteria,2J5TU@203691|Spirochaetes	203691|Spirochaetes	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
SX2_k127_5592301_6	665571.STHERM_c17560	1.146e-37	149.0	COG0720@1|root,COG0720@2|Bacteria,2J80J@203691|Spirochaetes	203691|Spirochaetes	H	6-pyruvoyl tetrahydropterin synthase QueD family protein	queD	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
SX2_k127_5592301_1	665571.STHERM_c17550	1.728e-144	475.0	COG0769@1|root,COG0769@2|Bacteria,2J5HR@203691|Spirochaetes	203691|Spirochaetes	M	Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
SX2_k127_5592301_10	1307761.L21SP2_3480	0.0004085	53.0	COG0457@1|root,COG0457@2|Bacteria,2J7YH@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5592301_3	1307761.L21SP2_1595	2.394e-97	335.0	COG1181@1|root,COG1181@2|Bacteria,2J611@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
SX2_k127_5592301_5	665571.STHERM_c02040	8.882e-39	161.0	COG1600@1|root,COG1600@2|Bacteria,2JAKM@203691|Spirochaetes	203691|Spirochaetes	C	4Fe-4S double cluster binding domain	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Fer4_16
SX2_k127_5592301_9	720554.Clocl_4111	5.862e-23	100.0	COG1773@1|root,COG1773@2|Bacteria,1VEQC@1239|Firmicutes,24QUV@186801|Clostridia,3WKG3@541000|Ruminococcaceae	186801|Clostridia	C	PFAM Rubredoxin-type Fe(Cys)4 protein	rd	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
SX2_k127_5592301_2	1123274.KB899408_gene3912	6.099e-100	346.0	2EJFP@1|root,33D6N@2|Bacteria,2J5TW@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF5312
SX2_k127_5592301_0	889378.Spiaf_1825	5.342e-247	785.0	COG0317@1|root,COG0317@2|Bacteria,2J5JE@203691|Spirochaetes	203691|Spirochaetes	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	spoT	-	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
SX2_k127_5592301_7	1123274.KB899427_gene3298	3.289e-23	102.0	COG2890@1|root,COG2890@2|Bacteria,2J7VJ@203691|Spirochaetes	203691|Spirochaetes	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
SX2_k127_5594813_1	1123274.KB899422_gene48	9.974e-149	491.0	COG1022@1|root,COG1022@2|Bacteria,2J6MK@203691|Spirochaetes	203691|Spirochaetes	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
SX2_k127_5594813_3	886293.Sinac_0207	1.723e-33	145.0	COG0707@1|root,COG0707@2|Bacteria	2|Bacteria	M	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity	ugtP	-	2.4.1.315	ko:K03429	ko00561,ko01100,map00561,map01100	-	R02689,R04377	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT28	-	Glyco_tran_28_C,Glycos_transf_1,MGDG_synth
SX2_k127_5594813_0	665571.STHERM_c01340	6.05e-246	775.0	COG0021@1|root,COG0021@2|Bacteria,2J6KB@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
SX2_k127_5594813_2	96561.Dole_2142	1.286e-39	156.0	COG2129@1|root,COG2129@2|Bacteria,1RJJX@1224|Proteobacteria,42T2C@68525|delta/epsilon subdivisions,2WP7Q@28221|Deltaproteobacteria,2MQ17@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Metallophosphoesterase, calcineurin superfamily	-	-	-	ko:K07096	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2,Metallophos_3
SX2_k127_564349_3	526224.Bmur_2060	9.631e-32	134.0	COG1664@1|root,COG1664@2|Bacteria,2J8N1@203691|Spirochaetes	203691|Spirochaetes	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
SX2_k127_564349_2	573413.Spirs_2439	1.397e-45	168.0	COG0781@1|root,COG0781@2|Bacteria,2J7V3@203691|Spirochaetes	203691|Spirochaetes	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
SX2_k127_564349_5	1144275.COCOR_05400	1.436e-16	92.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,42MPK@68525|delta/epsilon subdivisions,2WJM1@28221|Deltaproteobacteria,2YVM8@29|Myxococcales	28221|Deltaproteobacteria	O	peptidylprolyl isomerase	nifM	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
SX2_k127_564349_0	889378.Spiaf_1628	5.92e-55	215.0	COG2214@1|root,COG2214@2|Bacteria,2J5G9@203691|Spirochaetes	203691|Spirochaetes	O	DnaJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
SX2_k127_564349_1	545695.TREAZ_1217	4.379e-47	182.0	2BZW8@1|root,32R5W@2|Bacteria,2J6GZ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_564349_4	665571.STHERM_c09830	9.143e-30	123.0	COG0716@1|root,COG0716@2|Bacteria,2J892@203691|Spirochaetes	203691|Spirochaetes	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_564885_3	926550.CLDAP_14190	1.637e-21	94.0	COG1945@1|root,COG1945@2|Bacteria	2|Bacteria	I	arginine decarboxylase activity	pdaD	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
SX2_k127_564885_0	1128421.JAGA01000004_gene2510	1.636e-151	489.0	COG1899@1|root,COG1899@2|Bacteria,2NR8I@2323|unclassified Bacteria	2|Bacteria	O	Deoxyhypusine synthase	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
SX2_k127_564885_1	926550.CLDAP_14200	8.558e-80	293.0	COG0010@1|root,COG0010@2|Bacteria,2G6IN@200795|Chloroflexi	200795|Chloroflexi	E	Arginase family	-	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
SX2_k127_564885_2	1121918.ARWE01000001_gene2818	4.19e-28	115.0	COG2414@1|root,COG2414@2|Bacteria,1R8M4@1224|Proteobacteria,42PRY@68525|delta/epsilon subdivisions,2WIS4@28221|Deltaproteobacteria,43TU8@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.6	ko:K11389	ko00010,ko01100,ko01120,ko01200,ko01230,map00010,map01100,map01120,map01200,map01230	M00001,M00002	R07159	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
SX2_k127_5656091_0	1121440.AUMA01000005_gene2642	1.521e-68	237.0	COG1181@1|root,COG1181@2|Bacteria,1MX3I@1224|Proteobacteria,42SA1@68525|delta/epsilon subdivisions,2WNIR@28221|Deltaproteobacteria,2M8FI@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
SX2_k127_5656091_1	545694.TREPR_1180	7.501e-62	234.0	COG2815@1|root,COG2815@2|Bacteria,2J5J2@203691|Spirochaetes	203691|Spirochaetes	S	Pasta domain protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA
SX2_k127_5656091_2	243276.TPANIC_0756	2.22e-57	207.0	COG0223@1|root,COG0223@2|Bacteria,2J621@203691|Spirochaetes	203691|Spirochaetes	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
SX2_k127_5657069_3	1303518.CCALI_00907	2.389e-33	138.0	COG3534@1|root,COG3534@2|Bacteria	2|Bacteria	G	alpha-L-arabinofuranosidase	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
SX2_k127_5657069_7	794903.OPIT5_17745	9.989e-07	58.0	COG3534@1|root,COG3534@2|Bacteria,46TJZ@74201|Verrucomicrobia,3K9HJ@414999|Opitutae	414999|Opitutae	G	alpha-L-arabinofuranosidase domain protein	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
SX2_k127_5657069_2	573413.Spirs_1013	2.5e-80	280.0	COG2114@1|root,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Guanylate_cyc
SX2_k127_5657069_8	517418.Ctha_2336	0.0004539	51.0	COG1262@1|root,COG1470@1|root,COG1262@2|Bacteria,COG1470@2|Bacteria,1FFBZ@1090|Chlorobi	1090|Chlorobi	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
SX2_k127_5657069_5	742817.HMPREF9449_03103	7.363e-25	110.0	COG1262@1|root,COG1262@2|Bacteria,4NEUZ@976|Bacteroidetes,2G2PJ@200643|Bacteroidia,231SM@171551|Porphyromonadaceae	976|Bacteroidetes	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA
SX2_k127_5657069_6	868131.MSWAN_1978	1.899e-15	89.0	COG2083@1|root,arCOG01921@2157|Archaea,2Y13G@28890|Euryarchaeota	28890|Euryarchaeota	S	Belongs to the UPF0216 family	-	-	-	ko:K09737	-	-	-	-	ko00000	-	-	-	DUF61
SX2_k127_5657069_4	186497.PF0184	1.385e-28	125.0	COG1394@1|root,arCOG04101@2157|Archaea,2XTQ5@28890|Euryarchaeota,242NT@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
SX2_k127_5657069_0	399550.Smar_1170	1.099e-211	676.0	COG1156@1|root,arCOG00865@2157|Archaea,2XPKW@28889|Crenarchaeota	28889|Crenarchaeota	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
SX2_k127_5657069_1	633148.Tagg_0079	4.534e-85	288.0	COG1155@1|root,arCOG00868@2157|Archaea,2XPZE@28889|Crenarchaeota	28889|Crenarchaeota	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044464,GO:0044769,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132,GO:1902600	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
SX2_k127_5657698_0	1293054.HSACCH_01641	2.019e-182	580.0	COG3333@1|root,COG3333@2|Bacteria,1TPE7@1239|Firmicutes,24ZIP@186801|Clostridia	186801|Clostridia	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
SX2_k127_5657698_7	457398.HMPREF0326_01309	4e-15	81.0	COG0679@1|root,COG0679@2|Bacteria,1QKS6@1224|Proteobacteria,435R5@68525|delta/epsilon subdivisions,2X05P@28221|Deltaproteobacteria,2MAPN@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Auxin Efflux Carrier	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	-
SX2_k127_5657698_4	411464.DESPIG_01079	5.084e-33	134.0	COG0679@1|root,COG0679@2|Bacteria,1QKS6@1224|Proteobacteria,435R5@68525|delta/epsilon subdivisions,2X05P@28221|Deltaproteobacteria,2MAPN@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Auxin Efflux Carrier	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	-
SX2_k127_5657698_1	357808.RoseRS_3074	3.524e-91	310.0	COG0667@1|root,COG0667@2|Bacteria,2G6BF@200795|Chloroflexi,377XY@32061|Chloroflexia	32061|Chloroflexia	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SX2_k127_5657698_5	1379270.AUXF01000001_gene2268	1.723e-23	118.0	COG2267@1|root,COG2267@2|Bacteria,1ZUNN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
SX2_k127_5657698_3	933262.AXAM01000002_gene504	2.362e-51	204.0	COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BSJ@68525|delta/epsilon subdivisions,2X73B@28221|Deltaproteobacteria,2MI6A@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
SX2_k127_5657698_6	1294273.roselon_01162	4.944e-16	92.0	COG2208@1|root,COG2208@2|Bacteria,1N4K5@1224|Proteobacteria,2TS77@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	response regulator	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HATPase_c_2,Response_reg,SpoIIE
SX2_k127_5657698_2	1094980.Mpsy_0812	2.283e-61	233.0	COG3322@1|root,COG3920@1|root,arCOG02335@2157|Archaea,arCOG04446@2157|Archaea,2Y7UT@28890|Euryarchaeota,2NBMR@224756|Methanomicrobia	224756|Methanomicrobia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_2
SX2_k127_5690256_0	889378.Spiaf_0080	2.537e-198	659.0	COG1252@1|root,COG1252@2|Bacteria,2J79T@203691|Spirochaetes	203691|Spirochaetes	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
SX2_k127_5690256_1	555079.Toce_0687	3.134e-75	286.0	COG1477@1|root,COG1477@2|Bacteria,1TR9C@1239|Firmicutes,248KJ@186801|Clostridia,42FAD@68295|Thermoanaerobacterales	186801|Clostridia	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	apbE	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
SX2_k127_5690256_3	500635.MITSMUL_05255	4.55e-58	220.0	COG0600@1|root,COG0600@2|Bacteria,1V3NA@1239|Firmicutes,4H2YK@909932|Negativicutes	909932|Negativicutes	P	ABC transporter, permease protein	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
SX2_k127_5690256_2	1121456.ATVA01000013_gene853	3.456e-62	226.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,42MQ5@68525|delta/epsilon subdivisions,2WK19@28221|Deltaproteobacteria,2MH0B@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
SX2_k127_5690256_5	545695.TREAZ_2925	9.523e-40	166.0	COG0715@1|root,COG0715@2|Bacteria,2J7TW@203691|Spirochaetes	203691|Spirochaetes	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
SX2_k127_5690256_4	926561.KB900622_gene616	1.237e-56	211.0	COG1575@1|root,COG1575@2|Bacteria,1TSZV@1239|Firmicutes,24DJF@186801|Clostridia,3WBRF@53433|Halanaerobiales	186801|Clostridia	H	UbiA prenyltransferase family	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	iHN637.CLJU_RS19835	UbiA
SX2_k127_5696319_0	530564.Psta_3290	3.326e-127	429.0	COG5316@1|root,COG5316@2|Bacteria,2IY3B@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
SX2_k127_5696319_3	906968.Trebr_0476	2.924e-49	187.0	COG0705@1|root,COG0705@2|Bacteria,2J7J3@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Rhomboid family	-	-	-	ko:K02441	-	-	-	-	ko00000	-	-	-	Rhomboid
SX2_k127_5696319_4	717605.Theco_2678	4.567e-25	119.0	COG0477@1|root,COG2814@2|Bacteria,1V19N@1239|Firmicutes,4HDX3@91061|Bacilli,26TWU@186822|Paenibacillaceae	91061|Bacilli	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX2_k127_5696319_2	573413.Spirs_0879	3.623e-52	201.0	COG0013@1|root,COG0013@2|Bacteria,2J75I@203691|Spirochaetes	203691|Spirochaetes	J	alanyl tRNA synthetase	-	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
SX2_k127_5696319_1	368408.Tpen_0002	9.376e-65	235.0	COG1363@1|root,arCOG01518@2157|Archaea,2XPWC@28889|Crenarchaeota	28889|Crenarchaeota	G	peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
SX2_k127_5711640_4	1123242.JH636434_gene4709	3.132e-28	119.0	COG0724@1|root,COG0724@2|Bacteria,2IZPY@203682|Planctomycetes	203682|Planctomycetes	S	PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
SX2_k127_5711640_3	511051.CSE_02040	3.276e-66	246.0	COG0683@1|root,COG0683@2|Bacteria	2|Bacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
SX2_k127_5711640_0	1499967.BAYZ01000061_gene5973	1.336e-199	645.0	COG0112@1|root,COG0112@2|Bacteria,2NP28@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	-	-	2.1.2.1,2.2.1.8	ko:K00600,ko:K18847	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
SX2_k127_5711640_1	1121346.KB899818_gene2604	9.362e-147	471.0	COG3458@1|root,COG3458@2|Bacteria,1TS02@1239|Firmicutes,4HDID@91061|Bacilli,26QEJ@186822|Paenibacillaceae	91061|Bacilli	Q	Acetyl esterase	cah	-	3.1.1.41	ko:K01060	ko00311,ko01130,map00311,map01130	-	R03062	RC00020,RC00041	ko00000,ko00001,ko01000	-	-	-	AXE1
SX2_k127_5711640_2	1121405.dsmv_2904	2.879e-69	238.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,42MV4@68525|delta/epsilon subdivisions,2WKHZ@28221|Deltaproteobacteria,2MI2I@213118|Desulfobacterales	28221|Deltaproteobacteria	F	PFAM AICARFT IMPCHase bienzyme	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
SX2_k127_5760888_10	1123274.KB899426_gene2795	4.272e-57	222.0	COG0726@1|root,COG0726@2|Bacteria,2J5Y1@203691|Spirochaetes	203691|Spirochaetes	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Polysacc_deac_1
SX2_k127_5760888_6	459349.CLOAM1469	4.114e-92	312.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	galE	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	4.2.1.46,5.1.3.2	ko:K01710,ko:K01784	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R02984,R06513	RC00289,RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
SX2_k127_5760888_2	665571.STHERM_c13320	8.311e-146	475.0	COG0462@1|root,COG0462@2|Bacteria,2J5IY@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the ribose-phosphate pyrophosphokinase family	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
SX2_k127_5760888_3	1121342.AUCO01000028_gene1297	9.418e-135	439.0	COG0075@1|root,COG0075@2|Bacteria,1TPS0@1239|Firmicutes,24919@186801|Clostridia,36E72@31979|Clostridiaceae	186801|Clostridia	E	Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
SX2_k127_5760888_7	744872.Spica_2328	2.593e-90	320.0	COG0169@1|root,COG0710@1|root,COG0169@2|Bacteria,COG0710@2|Bacteria,2J570@203691|Spirochaetes	203691|Spirochaetes	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25,4.2.1.10	ko:K13832	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413,R03084	RC00206,RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I,Shikimate_DH,Shikimate_dh_N
SX2_k127_5760888_16	1480694.DC28_04175	3.492e-15	90.0	28VUA@1|root,2ZHVZ@2|Bacteria,2J8SW@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5760888_1	1449063.JMLS01000001_gene4614	3.569e-206	648.0	COG0673@1|root,COG0673@2|Bacteria,1TSUT@1239|Firmicutes,4HDBM@91061|Bacilli,26R1T@186822|Paenibacillaceae	91061|Bacilli	S	Oxidoreductase family, C-terminal alpha/beta domain	yteT	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX2_k127_5760888_9	665571.STHERM_c01930	5.233e-69	241.0	COG1811@1|root,COG1811@2|Bacteria,2J7KZ@203691|Spirochaetes	203691|Spirochaetes	S	Na channel or pump	-	-	-	ko:K07150	-	-	-	-	ko00000	-	-	-	DUF554
SX2_k127_5760888_0	744872.Spica_0331	0.0	1178.0	COG0058@1|root,COG0058@2|Bacteria,2J5KC@203691|Spirochaetes	203691|Spirochaetes	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	malP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
SX2_k127_5760888_4	573413.Spirs_2474	4.967e-126	418.0	COG0786@1|root,COG0786@2|Bacteria,2J7YK@203691|Spirochaetes	203691|Spirochaetes	E	glutamate symporter	gltS	-	-	ko:K03312	-	-	-	-	ko00000,ko02000	2.A.27	-	-	Glt_symporter
SX2_k127_5760888_5	1123274.KB899409_gene467	1.389e-110	372.0	COG1109@1|root,COG1109@2|Bacteria,2J5GY@203691|Spirochaetes	203691|Spirochaetes	G	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
SX2_k127_5760888_14	1313292.BCO_0082700	8.021e-23	114.0	COG1652@1|root,COG1652@2|Bacteria	2|Bacteria	S	positive regulation of growth rate	lysM	-	-	-	-	-	-	-	-	-	-	-	LysM
SX2_k127_5760888_13	1121946.AUAX01000011_gene4089	1.084e-29	136.0	COG2273@1|root,COG2273@2|Bacteria,2GKFN@201174|Actinobacteria,4DH60@85008|Micromonosporales	201174|Actinobacteria	G	Hydrolase Family 16	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,F5_F8_type_C
SX2_k127_5760888_12	573413.Spirs_3908	1.54e-33	143.0	COG3712@1|root,COG3712@2|Bacteria	2|Bacteria	PT	iron ion homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	DUF4974,FecR
SX2_k127_5760888_11	573413.Spirs_3908	1.811e-35	144.0	COG3712@1|root,COG3712@2|Bacteria	2|Bacteria	PT	iron ion homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	DUF4974,FecR
SX2_k127_5760888_15	1307761.L21SP2_0210	1.9e-19	93.0	COG3712@1|root,COG3712@2|Bacteria,2J9H5@203691|Spirochaetes	203691|Spirochaetes	PT	iron ion homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	FecR
SX2_k127_5760888_8	906968.Trebr_1266	9.321e-77	261.0	COG3842@1|root,COG3842@2|Bacteria,2J5T3@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
SX2_k127_5773571_1	221027.JO40_11940	4.645e-11	68.0	COG1334@1|root,COG1334@2|Bacteria,2J8TD@203691|Spirochaetes	203691|Spirochaetes	N	FlaG protein	flaG	-	-	ko:K06603	-	-	-	-	ko00000,ko02035	-	-	-	FlaG
SX2_k127_5773571_0	665571.STHERM_c07710	1.863e-171	560.0	COG1345@1|root,COG1345@2|Bacteria,2J6CW@203691|Spirochaetes	203691|Spirochaetes	N	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end	fliD	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	-	ko:K02407	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliD_C,FliD_N
SX2_k127_5794967_2	1382304.JNIL01000001_gene496	6.197e-73	248.0	COG0753@1|root,COG0753@2|Bacteria,1TPPV@1239|Firmicutes,4H9XQ@91061|Bacilli	91061|Bacilli	P	Belongs to the catalase family	katA	GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070887,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1990748	1.11.1.6	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	M00532	R00009,R00602,R02670	RC00034,RC00767,RC02141,RC02755	ko00000,ko00001,ko00002,ko01000	-	-	-	Catalase,Catalase-rel
SX2_k127_5794967_3	1121468.AUBR01000017_gene2393	7.881e-30	126.0	COG0735@1|root,COG0735@2|Bacteria,1V400@1239|Firmicutes,24JS4@186801|Clostridia,42GE8@68295|Thermoanaerobacterales	186801|Clostridia	P	Ferric uptake regulator, Fur family	perR	-	-	ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
SX2_k127_5794967_0	1499967.BAYZ01000115_gene2932	0.0	1029.0	COG0112@1|root,COG0404@1|root,COG0112@2|Bacteria,COG0404@2|Bacteria,2NP28@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	gcvT	GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008483,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0016769,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204	2.1.2.1,2.1.2.10,2.2.1.8	ko:K00600,ko:K00605,ko:K18847	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R01221,R02300,R04125,R09099	RC00022,RC00069,RC00112,RC00183,RC01583,RC02834,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C,SHMT
SX2_k127_5794967_1	309798.COPRO5265_0387	1.044e-188	601.0	COG0021@1|root,COG0021@2|Bacteria	2|Bacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_N,XFP,XFP_N
SX2_k127_5799823_0	744872.Spica_0966	3.911e-46	169.0	COG0231@1|root,COG0231@2|Bacteria,2J69Z@203691|Spirochaetes	203691|Spirochaetes	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
SX2_k127_5799823_1	649638.Trad_2902	3.709e-33	143.0	COG0477@1|root,COG2814@2|Bacteria,1WJAR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EGP	PFAM Major Facilitator Superfamily	-	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1
SX2_k127_5799823_2	632292.Calhy_2165	1.621e-15	81.0	COG0119@1|root,COG0119@2|Bacteria,1TP4Y@1239|Firmicutes,2485A@186801|Clostridia,42EXZ@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
SX2_k127_5810572_1	767817.Desgi_2199	3.936e-16	91.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,263KR@186807|Peptococcaceae	186801|Clostridia	NT	Methyl-accepting chemotaxis protein (MCP) signaling domain	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,CZB,HAMP,MCPsignal
SX2_k127_5810572_0	643648.Slip_0158	4.362e-55	207.0	COG0472@1|root,COG0472@2|Bacteria,1TP9V@1239|Firmicutes,247M7@186801|Clostridia,42KFG@68298|Syntrophomonadaceae	186801|Clostridia	M	Glycosyl transferase family 4	tagO	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
SX2_k127_5810572_2	1307761.L21SP2_0923	1.844e-15	83.0	COG2214@1|root,COG2214@2|Bacteria,2J9HD@203691|Spirochaetes	203691|Spirochaetes	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
SX2_k127_5810572_3	2903.EOD13881	2.669e-11	65.0	COG0253@1|root,2QQKJ@2759|Eukaryota	2759|Eukaryota	E	diaminopimelate epimerase activity	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
SX2_k127_5836239_1	744872.Spica_1803	2.074e-41	156.0	COG0497@1|root,COG0497@2|Bacteria,2J5E5@203691|Spirochaetes	203691|Spirochaetes	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
SX2_k127_5836239_0	1480694.DC28_02200	2.074e-85	297.0	2E1YA@1|root,32X70@2|Bacteria,2J5Q9@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5836239_2	906968.Trebr_1664	4.636e-39	149.0	COG0295@1|root,COG0295@2|Bacteria,2J80W@203691|Spirochaetes	203691|Spirochaetes	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	cdd	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
SX2_k127_5836239_4	545694.TREPR_0805	5.895e-21	106.0	2C8R1@1|root,2ZG03@2|Bacteria,2J6QN@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5836239_5	526224.Bmur_0013	1.742e-20	106.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	ko:K08642	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M23
SX2_k127_5836239_3	665571.STHERM_c08880	3.425e-30	126.0	COG2227@1|root,COG2227@2|Bacteria,2J6CB@203691|Spirochaetes	203691|Spirochaetes	H	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
SX2_k127_5839538_8	1101190.ARWB01000001_gene3391	2.47e-10	73.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2TR46@28211|Alphaproteobacteria,36XG2@31993|Methylocystaceae	28211|Alphaproteobacteria	T	His Kinase A (phospho-acceptor) domain	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_4,PAS_8
SX2_k127_5839538_5	1394178.AWOO02000053_gene8107	2.474e-21	107.0	COG0642@1|root,COG2205@2|Bacteria,2GK1J@201174|Actinobacteria,4EGGN@85012|Streptosporangiales	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	afsQ2	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K07654	ko02020,map02020	M00461	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
SX2_k127_5839538_7	925409.KI911562_gene374	2.526e-16	91.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
SX2_k127_5839538_9	383372.Rcas_2995	2.819e-08	66.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	htrA	GO:0008150,GO:0009266,GO:0009628,GO:0050896	3.4.21.107	ko:K04691,ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
SX2_k127_5839538_1	644966.Tmar_1635	6.508e-66	232.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,3WDTI@538999|Clostridiales incertae sedis	186801|Clostridia	K	Transcriptional regulatory protein, C terminal	phoP	-	-	ko:K02483,ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SX2_k127_5839538_4	573413.Spirs_3968	4.72e-23	104.0	COG1917@1|root,COG1917@2|Bacteria,2JB5G@203691|Spirochaetes	203691|Spirochaetes	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SX2_k127_5839538_2	1395587.P364_0116415	2.162e-37	144.0	COG5646@1|root,COG5646@2|Bacteria,1V6QB@1239|Firmicutes,4HINV@91061|Bacilli,26YRN@186822|Paenibacillaceae	91061|Bacilli	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
SX2_k127_5839538_3	1713.JOFV01000004_gene3311	1.303e-27	115.0	2EG8Z@1|root,332XF@2|Bacteria,2GTHG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5839538_10	67373.JOBF01000016_gene4799	3.725e-05	57.0	COG3568@1|root,COG3568@2|Bacteria	2|Bacteria	N	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
SX2_k127_5839538_0	760011.Spico_0166	7.87e-81	303.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
SX2_k127_5839538_6	491915.Aflv_1454	4.262e-18	85.0	COG0262@1|root,COG0262@2|Bacteria,1VB80@1239|Firmicutes,4HIGJ@91061|Bacilli,21W29@150247|Anoxybacillus	91061|Bacilli	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	dfrA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
SX2_k127_5859484_1	1123274.KB899409_gene559	4.313e-76	263.0	COG0498@1|root,COG0498@2|Bacteria,2J84W@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SX2_k127_5859484_0	204669.Acid345_3014	8.916e-119	425.0	COG0784@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,3Y64H@57723|Acidobacteria,2JM5F@204432|Acidobacteriia	204432|Acidobacteriia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
SX2_k127_5859484_2	1304880.JAGB01000002_gene2035	6.154e-08	56.0	COG2211@1|root,COG2211@2|Bacteria,1URUG@1239|Firmicutes,248SK@186801|Clostridia	186801|Clostridia	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX2_k127_5871864_0	886293.Sinac_3570	3.137e-155	516.0	COG0784@1|root,COG2198@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG5002@2|Bacteria,2J4YH@203682|Planctomycetes	203682|Planctomycetes	T	His Kinase A (phosphoacceptor	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,Response_reg
SX2_k127_5871864_9	1385935.N836_01620	1.531e-89	310.0	COG0655@1|root,COG0655@2|Bacteria,1GB8R@1117|Cyanobacteria,1HDV7@1150|Oscillatoriales	1117|Cyanobacteria	S	Nadph-dependent fmn reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
SX2_k127_5871864_6	552811.Dehly_0206	3.317e-95	333.0	COG0477@1|root,COG0477@2|Bacteria,2G7N2@200795|Chloroflexi	200795|Chloroflexi	P	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX2_k127_5871864_2	1120999.JONM01000012_gene2267	4.354e-130	446.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WGK9@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,Response_reg
SX2_k127_5871864_8	416591.Tlet_1113	3.48e-91	317.0	COG0165@1|root,COG0165@2|Bacteria	2|Bacteria	E	argininosuccinate lyase activity	argH2	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
SX2_k127_5871864_3	1219084.AP014508_gene2041	1.217e-106	352.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	lacG	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX2_k127_5871864_5	416591.Tlet_1116	5.326e-103	343.0	COG1175@1|root,COG1175@2|Bacteria,2GE17@200918|Thermotogae	200918|Thermotogae	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX2_k127_5871864_1	1219084.AP014508_gene2039	3.729e-147	477.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
SX2_k127_5871864_11	316274.Haur_0308	1.227e-73	269.0	COG0454@1|root,COG0456@2|Bacteria,2G7M3@200795|Chloroflexi,377HI@32061|Chloroflexia	32061|Chloroflexia	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5871864_7	333138.LQ50_20840	3.389e-95	332.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,4HACS@91061|Bacilli,1ZATG@1386|Bacillus	91061|Bacilli	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	6.2.1.48	ko:K02182	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding,AMP-binding_C
SX2_k127_5871864_4	1382306.JNIM01000001_gene663	3.758e-103	371.0	COG2366@1|root,COG2366@2|Bacteria,2G63N@200795|Chloroflexi	200795|Chloroflexi	S	PFAM peptidase S45 penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
SX2_k127_5871864_13	871968.DESME_05115	5.715e-08	66.0	COG2220@1|root,COG2220@2|Bacteria,1VF1I@1239|Firmicutes,24RMQ@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Lactamase_B_3
SX2_k127_5871864_10	876044.IMCC3088_2031	2.393e-82	287.0	COG2866@1|root,COG2866@2|Bacteria,1N6CX@1224|Proteobacteria,1RZAW@1236|Gammaproteobacteria,1J9GJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Protein of unknown function (DUF2817)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2817
SX2_k127_5871864_12	1384065.JAGS01000001_gene1702	7.786e-59	212.0	COG2020@1|root,COG2020@2|Bacteria,1V0PB@1239|Firmicutes,24AQ6@186801|Clostridia,3WMN7@541000|Ruminococcaceae	186801|Clostridia	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
SX2_k127_5876654_5	573413.Spirs_1501	7.628e-06	50.0	COG1022@1|root,COG1022@2|Bacteria,2J59B@203691|Spirochaetes	203691|Spirochaetes	I	COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming)	faa1	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
SX2_k127_5876654_1	1122605.KB893646_gene194	1.24e-154	497.0	COG0156@1|root,COG0156@2|Bacteria,4NFBU@976|Bacteroidetes,1IP7S@117747|Sphingobacteriia	976|Bacteroidetes	H	Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA	kbl	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
SX2_k127_5876654_0	744872.Spica_0890	2.21e-157	503.0	COG1063@1|root,COG1063@2|Bacteria,2J5R7@203691|Spirochaetes	203691|Spirochaetes	C	PFAM Alcohol dehydrogenase GroES-like	-	-	1.1.1.103,1.1.1.14,1.1.1.303,1.1.1.4	ko:K00004,ko:K00008,ko:K00060	ko00040,ko00051,ko00260,ko00650,ko01100,map00040,map00051,map00260,map00650,map01100	M00014	R00875,R01465,R01896,R02855,R02946,R10504	RC00085,RC00102,RC00205,RC00525	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
SX2_k127_5876654_3	96561.Dole_1695	3.705e-35	141.0	COG1145@1|root,COG1145@2|Bacteria,1MW11@1224|Proteobacteria,42NUY@68525|delta/epsilon subdivisions,2WK01@28221|Deltaproteobacteria,2MMY1@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
SX2_k127_5876654_2	1173028.ANKO01000116_gene5719	1.937e-65	236.0	COG2114@1|root,COG2114@2|Bacteria,1G6D6@1117|Cyanobacteria,1HB2S@1150|Oscillatoriales	1117|Cyanobacteria	T	COGs COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain)	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
SX2_k127_5876654_4	697281.Mahau_2753	8.627e-13	80.0	COG2768@1|root,COG2768@2|Bacteria,1TQAW@1239|Firmicutes,247IS@186801|Clostridia,42ETU@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4,Fer4_21
SX2_k127_5877168_1	1379270.AUXF01000004_gene3228	3.151e-92	308.0	COG0318@1|root,COG0318@2|Bacteria,1ZSXP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
SX2_k127_5877168_0	861299.J421_2605	2.634e-123	415.0	COG1432@1|root,COG1432@2|Bacteria,1ZSRW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	OST-HTH/LOTUS domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
SX2_k127_588138_1	1499967.BAYZ01000155_gene633	1.819e-165	533.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
SX2_k127_588138_3	1144275.COCOR_06540	1.263e-72	262.0	COG5459@1|root,COG5459@2|Bacteria,1MWMM@1224|Proteobacteria,42WIB@68525|delta/epsilon subdivisions,2WRHR@28221|Deltaproteobacteria,2YZNU@29|Myxococcales	28221|Deltaproteobacteria	J	Mitochondrial small ribosomal subunit Rsm22	-	-	-	-	-	-	-	-	-	-	-	-	Rsm22
SX2_k127_588138_0	1313421.JHBV01000041_gene3629	8.226e-167	554.0	COG2304@1|root,COG2304@2|Bacteria,4NK2W@976|Bacteroidetes	976|Bacteroidetes	M	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	OmpA,VIT,VWA,VWA_3
SX2_k127_588138_2	765912.Thimo_2149	2.084e-82	289.0	COG2304@1|root,COG2304@2|Bacteria,1N2UU@1224|Proteobacteria,1RXGJ@1236|Gammaproteobacteria,1WX7E@135613|Chromatiales	135613|Chromatiales	S	von Willebrand factor, type A	-	-	2.7.11.1	ko:K11912	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	VWA_2
SX2_k127_5900063_1	518766.Rmar_0136	6.112e-122	404.0	COG1509@1|root,COG1509@2|Bacteria,4NJ79@976|Bacteroidetes,1FJ3Z@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Lysine-2,3-aminomutase	ablA	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,LAM_C,Radical_SAM
SX2_k127_5900063_0	1195236.CTER_3181	1.619e-231	728.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1TNZ1@1239|Firmicutes,247PS@186801|Clostridia,3WGWJ@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
SX2_k127_5900063_2	795359.TOPB45_0801	7.205e-27	116.0	COG2062@1|root,COG2062@2|Bacteria	2|Bacteria	T	phosphohistidine phosphatase, SixA	sixA	-	3.6.1.55	ko:K03574,ko:K08296	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	His_Phos_1
SX2_k127_5939483_0	635013.TherJR_1517	5.757e-11	75.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1TPMS@1239|Firmicutes,24858@186801|Clostridia,2603B@186807|Peptococcaceae	186801|Clostridia	NT	Signal transducing histidine kinase homodimeric	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
SX2_k127_5993461_0	573413.Spirs_2239	9.775e-89	299.0	COG0572@1|root,COG0572@2|Bacteria,2J6XC@203691|Spirochaetes	203691|Spirochaetes	F	Cytidine monophosphokinase	udk	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
SX2_k127_5993461_1	744872.Spica_0133	2.281e-78	272.0	COG0705@1|root,COG0705@2|Bacteria,2JASZ@203691|Spirochaetes	203691|Spirochaetes	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
SX2_k127_5993461_2	1173022.Cri9333_4411	1.272e-47	185.0	COG2199@1|root,COG3706@2|Bacteria,1G3FB@1117|Cyanobacteria,1H736@1150|Oscillatoriales	1117|Cyanobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HisKA_7TM,PAS_4,PAS_8
SX2_k127_6001444_4	1123274.KB899422_gene53	2.806e-29	121.0	COG1638@1|root,COG1638@2|Bacteria,2J5PX@203691|Spirochaetes	203691|Spirochaetes	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
SX2_k127_6001444_1	1307761.L21SP2_1275	2.496e-67	241.0	COG5660@1|root,2Z7TM@2|Bacteria,2JBFN@203691|Spirochaetes	203691|Spirochaetes	S	TRAP transporter T-component	-	-	-	-	-	-	-	-	-	-	-	-	TAtT
SX2_k127_6001444_2	332101.JIBU02000014_gene2472	1.212e-58	212.0	COG0546@1|root,COG0546@2|Bacteria,1V75Y@1239|Firmicutes,24DJG@186801|Clostridia,36IA3@31979|Clostridiaceae	186801|Clostridia	S	Haloacid dehalogenase-like hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
SX2_k127_6001444_0	1499967.BAYZ01000016_gene6508	5.805e-110	376.0	COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,2NQE8@2323|unclassified Bacteria	2|Bacteria	T	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	GAF,GAF_2,HD,HD_5
SX2_k127_6001444_3	1121920.AUAU01000022_gene2462	1.559e-31	131.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	ko:K02660,ko:K11525	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,EAL,GAF,GGDEF,HAMP,MCPsignal,PAS_3,PAS_4,PAS_7,dCache_1
SX2_k127_6002463_2	479434.Sthe_0322	1.489e-77	274.0	COG0012@1|root,COG0012@2|Bacteria,2G5UY@200795|Chloroflexi,27XGT@189775|Thermomicrobia	189775|Thermomicrobia	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
SX2_k127_6002463_8	889378.Spiaf_1686	2.008e-16	85.0	COG1933@1|root,COG1933@2|Bacteria	2|Bacteria	L	exodeoxyribonuclease I activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DUF5050,DZR,Guanylate_cyc,TPR_12
SX2_k127_6002463_10	309799.DICTH_1706	1.982e-12	81.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,CBM9_1,PEGA,Peptidase_S9
SX2_k127_6002463_3	517418.Ctha_1299	1.752e-70	263.0	COG1226@1|root,COG1226@2|Bacteria	2|Bacteria	P	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)	yugO	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_N
SX2_k127_6002463_4	1307761.L21SP2_1920	7.472e-44	182.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	GGDEF,HATPase_c,HisKA,cNMP_binding
SX2_k127_6002463_5	545695.TREAZ_0764	5.22e-39	151.0	2EQ1S@1|root,33HN8@2|Bacteria,2J7UJ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_6002463_1	1121035.AUCH01000012_gene2970	1.099e-79	281.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,2VKNG@28216|Betaproteobacteria,2KUS1@206389|Rhodocyclales	206389|Rhodocyclales	J	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
SX2_k127_6002463_7	545695.TREAZ_0763	6.751e-34	135.0	COG1430@1|root,COG1430@2|Bacteria,2J80F@203691|Spirochaetes	203691|Spirochaetes	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
SX2_k127_6002463_9	596324.TREVI0001_1647	9.754e-15	76.0	COG1722@1|root,COG1722@2|Bacteria,2J8TJ@203691|Spirochaetes	203691|Spirochaetes	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
SX2_k127_6002463_0	545694.TREPR_2466	1.085e-122	411.0	COG1570@1|root,COG1570@2|Bacteria,2J5ED@203691|Spirochaetes	203691|Spirochaetes	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
SX2_k127_6002463_6	545694.TREPR_2465	4.542e-37	151.0	COG0535@1|root,COG0535@2|Bacteria,2J6HP@203691|Spirochaetes	203691|Spirochaetes	S	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
SX2_k127_602363_0	1123274.KB899410_gene3574	6.987e-149	479.0	COG0115@1|root,COG0115@2|Bacteria,2J6WR@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
SX2_k127_602363_1	744872.Spica_2060	2.882e-32	135.0	COG0457@1|root,COG0457@2|Bacteria,2J5XG@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
SX2_k127_6057479_7	665571.STHERM_c14370	1.854e-59	211.0	COG0162@1|root,COG0162@2|Bacteria,2J5ZS@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
SX2_k127_6057479_1	573413.Spirs_3573	1.955e-131	442.0	COG0815@1|root,COG0815@2|Bacteria,2J60T@203691|Spirochaetes	203691|Spirochaetes	M	Transfers the fatty acyl group on membrane lipoproteins	cutE	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
SX2_k127_6057479_6	665571.STHERM_c04580	3.377e-63	229.0	COG2231@1|root,COG2231@2|Bacteria	2|Bacteria	L	endonuclease III	magIII	-	-	ko:K07457	-	-	-	-	ko00000	-	-	-	HhH-GPD
SX2_k127_6057479_2	717605.Theco_2601	1.139e-107	362.0	COG0524@1|root,COG0524@2|Bacteria,1TT7Y@1239|Firmicutes,4HC0B@91061|Bacilli,26U8T@186822|Paenibacillaceae	91061|Bacilli	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
SX2_k127_6057479_4	744872.Spica_1614	8.756e-84	298.0	COG5360@1|root,COG5360@2|Bacteria,2J6PR@203691|Spirochaetes	203691|Spirochaetes	S	Heparinase II/III-like protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_6057479_12	1121354.AQUV01000001_gene1344	7.443e-08	57.0	COG0268@1|root,COG0268@2|Bacteria,2IQ73@201174|Actinobacteria,22NVQ@1653|Corynebacteriaceae	201174|Actinobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
SX2_k127_6057479_9	760011.Spico_1237	9.574e-31	124.0	COG0776@1|root,COG0776@2|Bacteria,2J7PW@203691|Spirochaetes	203691|Spirochaetes	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hup	-	-	ko:K04764,ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
SX2_k127_6057479_0	665571.STHERM_c18560	5.813e-161	523.0	COG0815@1|root,COG0815@2|Bacteria,2J60T@203691|Spirochaetes	203691|Spirochaetes	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
SX2_k127_6057479_5	1480694.DC28_03065	1.166e-82	291.0	COG0745@1|root,COG0745@2|Bacteria,2J7JA@203691|Spirochaetes	203691|Spirochaetes	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
SX2_k127_6057479_10	1480694.DC28_03070	9.907e-21	97.0	COG2114@1|root,COG2114@2|Bacteria,2JAV7@203691|Spirochaetes	203691|Spirochaetes	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_6057479_8	1307761.L21SP2_1378	6.298e-36	140.0	COG1664@1|root,COG1664@2|Bacteria,2J85N@203691|Spirochaetes	203691|Spirochaetes	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
SX2_k127_6057479_3	573413.Spirs_3180	3.105e-85	305.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,2J8AZ@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM competence damage-inducible protein CinA N-terminal domain	cinA	-	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
SX2_k127_6057479_11	744872.Spica_1604	7.04e-09	64.0	COG1158@1|root,COG1158@2|Bacteria,2J5BW@203691|Spirochaetes	203691|Spirochaetes	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
SX2_k127_6058243_11	760568.Desku_2999	3.176e-17	85.0	COG4747@1|root,COG4747@2|Bacteria,1V7U2@1239|Firmicutes,24JE5@186801|Clostridia,2629K@186807|Peptococcaceae	186801|Clostridia	S	PFAM Amino acid-binding ACT	-	-	-	-	-	-	-	-	-	-	-	-	ACT
SX2_k127_6058243_2	574087.Acear_1788	4.384e-169	543.0	COG1541@1|root,COG1541@2|Bacteria,1TQA1@1239|Firmicutes,248G9@186801|Clostridia	186801|Clostridia	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
SX2_k127_6058243_9	555779.Dthio_PD2626	1.033e-34	138.0	COG4747@1|root,COG4747@2|Bacteria,1RDCG@1224|Proteobacteria,42RTD@68525|delta/epsilon subdivisions,2WNC2@28221|Deltaproteobacteria,2MBI7@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM Amino acid-binding ACT	-	-	-	-	-	-	-	-	-	-	-	-	ACT
SX2_k127_6058243_1	273121.WS0932	3.76e-171	548.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42PY9@68525|delta/epsilon subdivisions,2YQSR@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	H	coenzyme F390	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	-
SX2_k127_6058243_10	1220534.B655_0060	3.905e-28	130.0	COG0535@1|root,arCOG00938@2157|Archaea	2157|Archaea	P	PFAM Radical SAM domain protein	cmo	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
SX2_k127_6058243_8	931627.MycrhDRAFT_5098	2.82e-37	150.0	COG1215@1|root,COG1215@2|Bacteria,2IBMN@201174|Actinobacteria,239CX@1762|Mycobacteriaceae	201174|Actinobacteria	MQ	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_11
SX2_k127_6058243_13	27923.ML01833a-PA	3.062e-06	60.0	28K3T@1|root,2QSIA@2759|Eukaryota,3974K@33154|Opisthokonta,3BBX0@33208|Metazoa	2759|Eukaryota	S	Protein of unknown function (DUF2723)	TMEM260	-	-	-	-	-	-	-	-	-	-	-	DUF2723
SX2_k127_6058243_3	1033743.CAES01000033_gene1052	1.804e-113	376.0	COG0463@1|root,COG0463@2|Bacteria,1TPR3@1239|Firmicutes,4HC2Z@91061|Bacilli,26SJW@186822|Paenibacillaceae	91061|Bacilli	M	Glycosyltransferase	ykcC	-	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
SX2_k127_6058243_12	1291050.JAGE01000001_gene2026	9.485e-15	89.0	COG2246@1|root,COG2246@2|Bacteria,1VFGI@1239|Firmicutes,24RJP@186801|Clostridia	186801|Clostridia	S	PFAM GtrA family protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
SX2_k127_6058243_6	1254432.SCE1572_42910	6.955e-52	209.0	COG3463@1|root,COG3463@2|Bacteria	2|Bacteria	T	Predicted membrane protein (DUF2079)	-	-	2.7.13.3	ko:K07778	ko02020,map02020	M00479	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF2079
SX2_k127_6058243_4	1142394.PSMK_28660	1.93e-91	316.0	COG0836@1|root,COG0836@2|Bacteria,2IXAR@203682|Planctomycetes	203682|Planctomycetes	M	Mannose-1-phosphate guanylyltransferase	-	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
SX2_k127_6058243_0	584708.Apau_0592	4.469e-185	591.0	COG0017@1|root,COG0017@2|Bacteria,3T9TP@508458|Synergistetes	508458|Synergistetes	J	PFAM tRNA synthetase class II (D K and N)	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
SX2_k127_6058243_5	573413.Spirs_3148	1.685e-54	207.0	COG1536@1|root,COG1536@2|Bacteria,2J6EK@203691|Spirochaetes	203691|Spirochaetes	N	flagellar motor switch protein	fliG-1	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
SX2_k127_6058243_7	1480694.DC28_07185	8.95e-47	182.0	2DBQ8@1|root,2ZACX@2|Bacteria,2J648@203691|Spirochaetes	203691|Spirochaetes	S	Zinc dependent phospholipase C	-	-	-	-	-	-	-	-	-	-	-	-	Zn_dep_PLPC
SX2_k127_610430_0	357808.RoseRS_1742	4.92e-97	321.0	COG0693@1|root,COG0693@2|Bacteria,2G8B6@200795|Chloroflexi,3770W@32061|Chloroflexia	32061|Chloroflexia	S	TIGRFAM intracellular protease, PfpI family	-	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
SX2_k127_620375_6	545695.TREAZ_3490	1.469e-41	166.0	COG5012@1|root,COG5012@2|Bacteria	2|Bacteria	T	cobalamin binding	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_620375_7	415426.Hbut_0415	5.649e-20	104.0	COG1167@1|root,arCOG00492@2157|Archaea,2XPUJ@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM Aminotransferase class I and II	agt	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
SX2_k127_620375_1	1452718.JBOY01000171_gene1561	1.603e-133	449.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.5,3.6.1.45	ko:K01081,ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
SX2_k127_620375_4	338966.Ppro_0727	3.126e-55	200.0	COG0655@1|root,COG0655@2|Bacteria,1N3NQ@1224|Proteobacteria,42TRR@68525|delta/epsilon subdivisions,2WQ13@28221|Deltaproteobacteria,43VWV@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
SX2_k127_620375_0	1123008.KB905706_gene850	6.973e-194	629.0	COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,4NEM0@976|Bacteroidetes,2FWDE@200643|Bacteroidia	976|Bacteroidetes	IQ	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II,adh_short,adh_short_C2
SX2_k127_620375_3	445335.CBN_1409	3.777e-78	269.0	COG0235@1|root,COG0235@2|Bacteria,1TS5G@1239|Firmicutes,248NY@186801|Clostridia,36H4D@31979|Clostridiaceae	186801|Clostridia	G	Class II aldolase	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
SX2_k127_620375_5	1458275.AZ34_08275	5.858e-48	195.0	COG3386@1|root,COG3391@1|root,COG4783@1|root,COG3386@2|Bacteria,COG3391@2|Bacteria,COG4783@2|Bacteria,1R1XY@1224|Proteobacteria,2VX19@28216|Betaproteobacteria,4AJMH@80864|Comamonadaceae	28216|Betaproteobacteria	G	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL,TPR_2,TPR_8
SX2_k127_620375_2	717606.PaecuDRAFT_2136	1.33e-81	305.0	COG1520@1|root,COG3210@1|root,COG4412@1|root,COG5276@1|root,COG5492@1|root,COG1520@2|Bacteria,COG3210@2|Bacteria,COG4412@2|Bacteria,COG5276@2|Bacteria,COG5492@2|Bacteria,1TR9M@1239|Firmicutes,4HEPP@91061|Bacilli,26T62@186822|Paenibacillaceae	91061|Bacilli	U	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Cadherin-like,Cohesin,Invasin_D3,SLH
SX2_k127_62794_3	1396141.BATP01000023_gene731	1.275e-20	94.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	VWA
SX2_k127_62794_8	394503.Ccel_0847	0.0002154	52.0	2BW4G@1|root,2ZAQH@2|Bacteria,1UZFJ@1239|Firmicutes,24DAB@186801|Clostridia,36IC8@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_62794_7	1206737.BAGF01000044_gene2688	2.988e-06	59.0	COG0477@1|root,COG2814@2|Bacteria,2H8UD@201174|Actinobacteria,4FV1Y@85025|Nocardiaceae	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,MFS_1,Sugar_tr
SX2_k127_62794_9	321327.CYA_1760	0.0004045	50.0	COG2314@1|root,COG2314@2|Bacteria,1G8AE@1117|Cyanobacteria,1H1DU@1129|Synechococcus	1117|Cyanobacteria	S	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	TM2
SX2_k127_62794_6	1502852.FG94_03339	2.819e-06	59.0	28JAH@1|root,2Z95A@2|Bacteria,1MXKT@1224|Proteobacteria,2VI69@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Uncharacterised nucleotidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_5
SX2_k127_62794_0	1167006.UWK_01782	1.772e-52	197.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42S93@68525|delta/epsilon subdivisions,2X5GZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX2_k127_62794_1	247490.KSU1_C0427	4.307e-50	201.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
SX2_k127_62794_2	247490.KSU1_C0421	2.757e-40	170.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
SX2_k127_62794_4	1294265.JCM21738_888	3.761e-13	78.0	2DIKE@1|root,303IH@2|Bacteria,1TUK8@1239|Firmicutes,4IJMX@91061|Bacilli,1ZBGW@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_636436_3	1499967.BAYZ01000095_gene4256	2.484e-21	105.0	COG5426@1|root,COG5426@2|Bacteria	2|Bacteria	D	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_636436_4	555079.Toce_1356	1.389e-08	62.0	COG3086@1|root,COG3086@2|Bacteria,1VECS@1239|Firmicutes,25DMS@186801|Clostridia,42GWF@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM Positive regulator of sigma(E) RseC MucC	-	-	-	ko:K03803	-	-	-	-	ko00000,ko03021	-	-	-	RseC_MucC
SX2_k127_636436_0	1403819.BATR01000181_gene6205	1.634e-55	199.0	COG0494@1|root,COG0494@2|Bacteria,46Z4F@74201|Verrucomicrobia,2IWPE@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
SX2_k127_636436_5	1121468.AUBR01000009_gene2156	0.0005734	46.0	COG2355@1|root,COG2355@2|Bacteria,1UA7M@1239|Firmicutes,24AE6@186801|Clostridia,42F00@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM Peptidase M19, renal dipeptidase	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
SX2_k127_636436_2	665571.STHERM_c14880	6.555e-23	113.0	COG0170@1|root,COG0344@1|root,COG0170@2|Bacteria,COG0344@2|Bacteria	2|Bacteria	I	acyl-phosphate glycerol-3-phosphate acyltransferase activity	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
SX2_k127_636436_1	670487.Ocepr_0357	1.084e-39	155.0	COG0517@1|root,COG0517@2|Bacteria,1WNHR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	COGs COG2905 signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SX2_k127_643191_1	1303518.CCALI_00386	1.614e-105	364.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	-	-	-	ko:K19956	ko00051,map00051	-	R03234	RC00089	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
SX2_k127_643191_0	1125699.HMPREF9194_00401	2.621e-127	421.0	COG0613@1|root,COG0613@2|Bacteria,2J6D0@203691|Spirochaetes	203691|Spirochaetes	S	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_643191_2	926550.CLDAP_03280	1.141e-33	132.0	COG1957@1|root,COG1957@2|Bacteria,2G7IF@200795|Chloroflexi	200795|Chloroflexi	F	PFAM Inosine uridine-preferring nucleoside hydrolase	-	-	3.2.2.1	ko:K01239	ko00230,ko00760,ko01100,map00230,map00760,map01100	-	R01245,R01273,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	IU_nuc_hydro
SX2_k127_649478_1	1480694.DC28_14875	8.484e-71	255.0	COG0454@1|root,COG0456@2|Bacteria,2J7A2@203691|Spirochaetes	203691|Spirochaetes	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SX2_k127_649478_2	545695.TREAZ_2744	1.433e-65	237.0	COG0791@1|root,COG0791@2|Bacteria,2J73P@203691|Spirochaetes	203691|Spirochaetes	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_4
SX2_k127_649478_0	889378.Spiaf_2246	2.174e-78	274.0	COG0614@1|root,COG0614@2|Bacteria	2|Bacteria	P	abc-type fe3 -hydroxamate transport system, periplasmic component	hmuT	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
SX2_k127_649478_3	158189.SpiBuddy_2700	8.729e-29	123.0	COG1638@1|root,COG1638@2|Bacteria,2J7YC@203691|Spirochaetes	203691|Spirochaetes	G	extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
SX2_k127_666123_0	742738.HMPREF9460_00237	2.37e-122	398.0	COG0524@1|root,COG0524@2|Bacteria,1TRRY@1239|Firmicutes,248Y3@186801|Clostridia,2681M@186813|unclassified Clostridiales	186801|Clostridia	G	pfkB family carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
SX2_k127_666123_1	1304875.JAFZ01000001_gene1076	8.534e-111	367.0	COG0800@1|root,COG0800@2|Bacteria,3TAVM@508458|Synergistetes	508458|Synergistetes	G	PFAM KDPG and KHG aldolase	-	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
SX2_k127_666486_0	357808.RoseRS_1782	1.776e-27	120.0	COG1073@1|root,COG1073@2|Bacteria,2G8PF@200795|Chloroflexi,377Y4@32061|Chloroflexia	32061|Chloroflexia	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
SX2_k127_66857_8	1047013.AQSP01000140_gene2513	3.855e-08	57.0	COG1322@1|root,COG1322@2|Bacteria,2NPXU@2323|unclassified Bacteria	2|Bacteria	S	RmuC family	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
SX2_k127_66857_6	1321778.HMPREF1982_03663	7.457e-32	135.0	COG4902@1|root,COG4902@2|Bacteria,1UNE2@1239|Firmicutes,25H1F@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2202
SX2_k127_66857_0	573413.Spirs_0498	5.409e-107	355.0	COG0348@1|root,COG0348@2|Bacteria,2J5CW@203691|Spirochaetes	203691|Spirochaetes	C	4Fe-4S binding domain	-	-	-	ko:K02574	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_5
SX2_k127_66857_4	926569.ANT_29130	2.481e-38	155.0	COG0348@1|root,COG0348@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
SX2_k127_66857_3	404380.Gbem_1930	6.914e-48	185.0	COG0834@1|root,COG0834@2|Bacteria,1MV3Q@1224|Proteobacteria,42PQN@68525|delta/epsilon subdivisions,2WKV7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	ET	PFAM Extracellular solute-binding protein, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
SX2_k127_66857_2	926569.ANT_17620	1.91e-51	189.0	COG1309@1|root,COG1309@2|Bacteria,2G7DR@200795|Chloroflexi	200795|Chloroflexi	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_4,TetR_N
SX2_k127_66857_1	926569.ANT_17630	4.205e-93	332.0	COG0451@1|root,COG0451@2|Bacteria,2G84M@200795|Chloroflexi	200795|Chloroflexi	M	PFAM NAD-dependent epimerase dehydratase	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
SX2_k127_66857_5	398511.BpOF4_14470	5.732e-35	154.0	COG0300@1|root,COG0300@2|Bacteria,1TSJ3@1239|Firmicutes,4HDU5@91061|Bacilli,1ZBRZ@1386|Bacillus	91061|Bacilli	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	yqjQ	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
SX2_k127_66857_9	1348663.KCH_48290	5.116e-08	59.0	COG0697@1|root,COG0697@2|Bacteria,2I198@201174|Actinobacteria,2M1ER@2063|Kitasatospora	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SX2_k127_678414_4	744872.Spica_1135	3.356e-07	57.0	2A6A2@1|root,30V2P@2|Bacteria,2J9DJ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_678414_0	545694.TREPR_1730	1.554e-121	424.0	COG0621@1|root,COG0621@2|Bacteria,2J5GF@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
SX2_k127_678414_6	406124.ACPC01000020_gene3952	6.831e-05	55.0	COG0860@1|root,COG0860@2|Bacteria,1V3MD@1239|Firmicutes,4HHD1@91061|Bacilli,1ZBPF@1386|Bacillus	91061|Bacilli	M	n-acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,Glucosaminidase,SH3_3,SLH,SPOR
SX2_k127_678414_3	545695.TREAZ_3334	1.676e-35	156.0	2F8XC@1|root,34196@2|Bacteria,2J6EN@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_678414_1	1123274.KB899419_gene1993	3.875e-105	355.0	COG0618@1|root,COG0618@2|Bacteria,2J74X@203691|Spirochaetes	203691|Spirochaetes	S	DHHA1 domain	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
SX2_k127_679153_0	357808.RoseRS_1485	5.004e-226	724.0	COG0366@1|root,COG0366@2|Bacteria,2G7SV@200795|Chloroflexi	200795|Chloroflexi	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
SX2_k127_727516_5	1206743.BAGM01000053_gene1294	3.962e-10	66.0	COG1589@1|root,COG1589@2|Bacteria,2H4A4@201174|Actinobacteria,4FVIV@85025|Nocardiaceae	201174|Actinobacteria	M	Cell division protein FtsQ	ftsQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
SX2_k127_727516_3	1307761.L21SP2_1159	3.727e-89	306.0	COG0772@1|root,COG0772@2|Bacteria,2J58T@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
SX2_k127_727516_0	545695.TREAZ_0906	1.666e-130	427.0	COG0472@1|root,COG0472@2|Bacteria,2J6QK@203691|Spirochaetes	203691|Spirochaetes	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
SX2_k127_727516_2	665571.STHERM_c08940	1.922e-90	321.0	COG0770@1|root,COG0770@2|Bacteria,2J5GH@203691|Spirochaetes	203691|Spirochaetes	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
SX2_k127_727516_1	1480694.DC28_02235	7.239e-100	339.0	COG0275@1|root,COG0275@2|Bacteria,2J6DH@203691|Spirochaetes	203691|Spirochaetes	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
SX2_k127_727516_4	1123274.KB899413_gene873	1.035e-52	190.0	COG2001@1|root,COG2001@2|Bacteria,2J7XS@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
SX2_k127_736806_1	889378.Spiaf_1692	3.3e-114	385.0	COG0587@1|root,COG0587@2|Bacteria,2J5DA@203691|Spirochaetes	203691|Spirochaetes	L	DNA polymerase	-	-	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
SX2_k127_736806_3	382464.ABSI01000010_gene3321	1.257e-26	124.0	COG2706@1|root,COG3210@1|root,COG4733@1|root,COG2706@2|Bacteria,COG3210@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
SX2_k127_736806_4	906968.Trebr_1981	4.648e-07	62.0	2ANKV@1|root,31DK3@2|Bacteria,2JAP6@203691|Spirochaetes	203691|Spirochaetes	S	Bacterial SH3 domain	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
SX2_k127_736806_0	1480694.DC28_08450	9.486e-150	482.0	COG0686@1|root,COG0686@2|Bacteria,2J6R2@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the AlaDH PNT family	-	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
SX2_k127_736806_2	545694.TREPR_3857	2.231e-35	144.0	COG0457@1|root,COG0457@2|Bacteria,2J8BT@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
SX2_k127_749430_0	1123274.KB899413_gene882	1.048e-117	400.0	COG0497@1|root,COG0497@2|Bacteria,2J5E5@203691|Spirochaetes	203691|Spirochaetes	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
SX2_k127_749430_1	158189.SpiBuddy_1252	1.009e-66	239.0	COG0061@1|root,COG0061@2|Bacteria,2J5BE@203691|Spirochaetes	203691|Spirochaetes	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
SX2_k127_772902_0	545695.TREAZ_0409	4.403e-26	124.0	COG2604@1|root,COG2604@2|Bacteria,2J5AX@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF115	-	-	-	-	-	-	-	-	-	-	-	-	MAF_flag10
SX2_k127_774059_2	861299.J421_0838	3.38e-92	318.0	COG0446@1|root,COG2146@1|root,COG0446@2|Bacteria,COG2146@2|Bacteria,1ZV6A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
SX2_k127_774059_0	889378.Spiaf_0085	2.116e-195	632.0	COG1022@1|root,COG1022@2|Bacteria,2J9S5@203691|Spirochaetes	203691|Spirochaetes	I	Long-chain acyl-CoA synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
SX2_k127_774059_10	521011.Mpal_1250	1.082e-09	70.0	COG2339@1|root,arCOG02985@2157|Archaea	2157|Archaea	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
SX2_k127_774059_7	935863.AWZR01000009_gene8	1.165e-40	164.0	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,1RN7F@1236|Gammaproteobacteria,1X3AV@135614|Xanthomonadales	135614|Xanthomonadales	J	Responsible for synthesis of pseudouridine from uracil	rluD	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
SX2_k127_774059_8	1321778.HMPREF1982_02764	2.622e-31	142.0	COG3595@1|root,COG3595@2|Bacteria,1VD1Z@1239|Firmicutes,24F2A@186801|Clostridia	186801|Clostridia	S	Putative adhesin	-	-	-	ko:K11621	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	DUF4097
SX2_k127_774059_4	383372.Rcas_0518	8.587e-56	211.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX2_k127_774059_3	744872.Spica_0328	8.365e-72	256.0	2EYA0@1|root,33RIG@2|Bacteria,2J6Q4@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_774059_1	665571.STHERM_c17370	2.054e-122	410.0	COG0265@1|root,COG0265@2|Bacteria,2J5GT@203691|Spirochaetes	203691|Spirochaetes	O	periplasmic serine protease, Do	htrA	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
SX2_k127_774059_6	889378.Spiaf_1383	1.922e-53	194.0	COG1678@1|root,COG1678@2|Bacteria	2|Bacteria	K	ribonucleoside-diphosphate reductase activity	yqgE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
SX2_k127_774059_5	1191523.MROS_0856	8.755e-56	199.0	COG2606@1|root,COG2606@2|Bacteria	2|Bacteria	S	Cys-tRNA(Pro) hydrolase activity	-	-	-	ko:K03976,ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
SX2_k127_774059_9	1415778.JQMM01000001_gene2084	6.121e-11	64.0	2DU2E@1|root,33NN7@2|Bacteria,1P5P1@1224|Proteobacteria,1SV3F@1236|Gammaproteobacteria,1JBM0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_779934_9	1429046.RR21198_5479	5.832e-15	83.0	2CYFR@1|root,32T44@2|Bacteria,2HSE6@201174|Actinobacteria,4G6DE@85025|Nocardiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
SX2_k127_779934_12	68570.DC74_676	0.0001254	46.0	COG3335@1|root,COG3335@2|Bacteria,2I9RW@201174|Actinobacteria	201174|Actinobacteria	L	DDE superfamily endonuclease	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3
SX2_k127_779934_7	1340493.JNIF01000003_gene2055	1.396e-30	126.0	COG3415@1|root,COG3415@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07499	-	-	-	-	ko00000	-	-	-	HTH_23,HTH_29,HTH_32,HTH_33
SX2_k127_779934_6	479437.Elen_1856	1.197e-32	147.0	COG0247@1|root,COG2181@1|root,COG0247@2|Bacteria,COG2181@2|Bacteria,2GJ7M@201174|Actinobacteria,4CX38@84998|Coriobacteriia	84998|Coriobacteriia	C	Nitrate reductase gamma subunit	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8,Nitrate_red_gam
SX2_k127_779934_1	1121472.AQWN01000004_gene768	4.144e-124	416.0	COG0578@1|root,COG0578@2|Bacteria,1UJ0S@1239|Firmicutes,25ETI@186801|Clostridia,2601H@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM Glycerol-3-phosphate dehydrogenase, anaerobic A subunit	glpA	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,Fer2_BFD
SX2_k127_779934_10	1163407.UU7_00150	3.045e-08	62.0	COG2020@1|root,COG2020@2|Bacteria,1N936@1224|Proteobacteria,1SCXB@1236|Gammaproteobacteria,1X823@135614|Xanthomonadales	135614|Xanthomonadales	O	Methyltransferase	-	-	2.1.1.100	ko:K00587	ko00900,ko01130,map00900,map01130	-	R04496	RC00003,RC00460	ko00000,ko00001,ko01000	-	-	-	PEMT
SX2_k127_779934_11	196367.JNFG01000017_gene4102	1.062e-06	55.0	COG1487@1|root,COG1487@2|Bacteria,1MZQC@1224|Proteobacteria,2VTD0@28216|Betaproteobacteria,1K7SJ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PIN domain	-	-	-	ko:K07062	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN
SX2_k127_779934_5	1123288.SOV_4c00450	4.17e-45	185.0	COG0655@1|root,COG0655@2|Bacteria,1VUGD@1239|Firmicutes	1239|Firmicutes	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
SX2_k127_779934_4	158190.SpiGrapes_0551	2.232e-48	183.0	COG0568@1|root,COG0568@2|Bacteria,2J5M9@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086,ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
SX2_k127_779934_2	868131.MSWAN_2165	4.558e-121	406.0	COG2327@1|root,arCOG04826@2157|Archaea	2157|Archaea	S	PFAM Polysaccharide pyruvyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	PS_pyruv_trans
SX2_k127_779934_0	509191.AEDB02000076_gene1445	4.868e-266	868.0	COG1022@1|root,COG3320@1|root,COG1022@2|Bacteria,COG3320@2|Bacteria,1UVSP@1239|Firmicutes,24XTK@186801|Clostridia	186801|Clostridia	I	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
SX2_k127_779934_8	1131462.DCF50_p2424	6.067e-27	124.0	2DQ4Q@1|root,334QV@2|Bacteria,1VVNN@1239|Firmicutes,2513M@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_779934_3	1131462.DCF50_p2423	9.476e-64	234.0	COG2303@1|root,COG2303@2|Bacteria,1V115@1239|Firmicutes,24FDE@186801|Clostridia,263C0@186807|Peptococcaceae	186801|Clostridia	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
SX2_k127_783718_4	1155718.KB891878_gene5473	4.277e-30	128.0	COG0815@1|root,COG0815@2|Bacteria,2GP8X@201174|Actinobacteria	201174|Actinobacteria	M	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
SX2_k127_783718_0	518766.Rmar_1896	1.962e-215	689.0	COG1164@1|root,COG1164@2|Bacteria,4NFYH@976|Bacteroidetes,1FIWW@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	Oligopeptidase F	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
SX2_k127_783718_1	926569.ANT_27190	6.327e-208	663.0	COG1132@1|root,COG1132@2|Bacteria	2|Bacteria	V	(ABC) transporter	mdlB	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SX2_k127_783718_5	742726.HMPREF9448_01911	6.829e-29	124.0	COG2246@1|root,COG2246@2|Bacteria,4NXZ2@976|Bacteroidetes	976|Bacteroidetes	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
SX2_k127_783718_2	796940.HMPREF9628_01403	1.357e-76	271.0	COG1143@1|root,COG2878@1|root,COG1143@2|Bacteria,COG2878@2|Bacteria,1TQGD@1239|Firmicutes,24904@186801|Clostridia,25QGD@186804|Peptostreptococcaceae	186801|Clostridia	C	Electron transport complex	rnfB	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4,Fer4_13,Fer4_4,Fer4_9
SX2_k127_783718_3	1123009.AUID01000001_gene1055	3.708e-33	131.0	COG4657@1|root,COG4657@2|Bacteria,1TS06@1239|Firmicutes,247UE@186801|Clostridia,268RC@186813|unclassified Clostridiales	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfA	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
SX2_k127_792067_5	665571.STHERM_c12690	2.353e-25	109.0	COG0231@1|root,COG0231@2|Bacteria,2J69Z@203691|Spirochaetes	203691|Spirochaetes	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
SX2_k127_792067_3	1123274.KB899426_gene2781	1.231e-80	286.0	COG2269@1|root,COG2269@2|Bacteria,2J61T@203691|Spirochaetes	203691|Spirochaetes	J	synthetase (class II)	-	-	-	ko:K04568	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	tRNA-synt_2
SX2_k127_792067_0	665571.STHERM_c19750	9.05e-215	702.0	COG1026@1|root,COG1026@2|Bacteria,2J67R@203691|Spirochaetes	203691|Spirochaetes	S	peptidase, M16	-	-	-	ko:K06972	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M16C_assoc,Peptidase_M16,Peptidase_M16_C
SX2_k127_792067_1	665571.STHERM_c16110	2.577e-135	441.0	COG1234@1|root,COG1234@2|Bacteria,2J6E7@203691|Spirochaetes	203691|Spirochaetes	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
SX2_k127_792067_6	573413.Spirs_1931	4.336e-14	85.0	COG2199@1|root,COG2199@2|Bacteria,2J87P@203691|Spirochaetes	203691|Spirochaetes	T	(GGDEF) domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
SX2_k127_792067_4	880072.Desac_1616	1.585e-62	225.0	COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,42R55@68525|delta/epsilon subdivisions,2WKKG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
SX2_k127_792067_2	1123274.KB899415_gene2542	6.994e-81	287.0	COG2604@1|root,COG2604@2|Bacteria,2J5FD@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF115	-	-	-	-	-	-	-	-	-	-	-	-	MAF_flag10
SX2_k127_795888_5	1449976.KALB_5658	1.265e-46	175.0	COG0624@1|root,COG0624@2|Bacteria,2I8IJ@201174|Actinobacteria,4E62V@85010|Pseudonocardiales	201174|Actinobacteria	E	Peptidase dimerisation domain	-	-	3.5.1.18	ko:K01439,ko:K05831	ko00220,ko00300,ko01100,ko01120,ko01210,ko01230,map00220,map00300,map01100,map01120,map01210,map01230	M00016,M00031,M00763	R02734,R09779,R10933	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
SX2_k127_795888_4	744872.Spica_1991	6.398e-79	276.0	COG3858@1|root,COG3858@2|Bacteria,2J6UU@203691|Spirochaetes	203691|Spirochaetes	S	hydrolase, family 18	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18
SX2_k127_795888_2	1211579.PP4_32810	3.387e-91	313.0	COG1893@1|root,COG1893@2|Bacteria,1P0AW@1224|Proteobacteria,1TKSH@1236|Gammaproteobacteria,1YY2X@136845|Pseudomonas putida group	1236|Gammaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
SX2_k127_795888_3	391616.OA238_c17120	6.966e-87	308.0	COG1082@1|root,COG1082@2|Bacteria,1R5T9@1224|Proteobacteria,2U0P4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SX2_k127_795888_0	1499967.BAYZ01000103_gene3717	2.891e-154	498.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
SX2_k127_795888_1	639030.JHVA01000001_gene112	3.613e-140	459.0	COG0176@1|root,COG0176@2|Bacteria	2|Bacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
SX2_k127_795888_6	1123519.PSJM300_05595	8.661e-05	46.0	COG4221@1|root,COG4221@2|Bacteria,1MUU6@1224|Proteobacteria,1S3I6@1236|Gammaproteobacteria,1Z0NK@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SX2_k127_810402_0	1382356.JQMP01000003_gene2316	1.146e-117	392.0	COG1680@1|root,COG1680@2|Bacteria,2G6IE@200795|Chloroflexi	200795|Chloroflexi	V	PFAM Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SX2_k127_810402_3	573413.Spirs_0277	6.802e-48	177.0	2CA4A@1|root,32RQK@2|Bacteria,2J92B@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF4416)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4416
SX2_k127_810402_2	744872.Spica_2104	1.216e-51	203.0	2EW9N@1|root,33PNA@2|Bacteria,2J5CY@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_810402_5	666509.RCA23_c28150	0.0002642	54.0	COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,2TTX1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	COG1076 DnaJ-domain-containing proteins 1	djlA	-	-	ko:K05801	-	-	-	-	ko00000,ko03110	-	-	-	DnaJ,TerB
SX2_k127_810402_4	1144275.COCOR_02662	2.137e-19	94.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,42U04@68525|delta/epsilon subdivisions,2WQA9@28221|Deltaproteobacteria,2YVKS@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SX2_k127_810402_1	665571.STHERM_c18910	4.299e-54	195.0	COG0077@1|root,COG2876@1|root,COG0077@2|Bacteria,COG2876@2|Bacteria,2J644@203691|Spirochaetes	203691|Spirochaetes	H	PFAM DAHP synthetase I KDSA	pheA	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,DAHP_synth_1,PDT
SX2_k127_810878_2	1121920.AUAU01000018_gene1835	3.382e-15	76.0	COG0607@1|root,32YCZ@2|Bacteria,3Y5Z1@57723|Acidobacteria	57723|Acidobacteria	P	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
SX2_k127_810878_3	502025.Hoch_4588	3.626e-07	54.0	COG2331@1|root,COG2331@2|Bacteria,1N6Q9@1224|Proteobacteria,42V24@68525|delta/epsilon subdivisions,2WR87@28221|Deltaproteobacteria,2YW0Y@29|Myxococcales	28221|Deltaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
SX2_k127_810878_1	382464.ABSI01000005_gene1376	5.161e-29	120.0	COG3439@1|root,COG3439@2|Bacteria,46T7A@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
SX2_k127_810878_0	671143.DAMO_0692	8.333e-57	200.0	COG0302@1|root,COG0302@2|Bacteria,2NPAT@2323|unclassified Bacteria	2|Bacteria	H	GTP cyclohydrolase I	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006082,GO:0006139,GO:0006575,GO:0006725,GO:0006729,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009108,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0019752,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0042455,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901657,GO:1901659	2.7.6.3,3.5.4.16	ko:K00950,ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R03503,R04639,R05046,R05048	RC00002,RC00017,RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.folE,iIT341.HP0928,iJN678.folE,iNJ661.Rv3609c	GTP_cyclohydroI
SX2_k127_816284_0	1123274.KB899409_gene548	1.37e-131	425.0	COG0078@1|root,COG0078@2|Bacteria,2J5Q3@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the ATCase OTCase family	ygeW	-	-	-	-	-	-	-	-	-	-	-	OTCace,OTCace_N
SX2_k127_816284_2	926569.ANT_04390	1.045e-85	299.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
SX2_k127_816284_7	1499967.BAYZ01000013_gene6449	5.067e-05	56.0	COG1618@1|root,COG1618@2|Bacteria	2|Bacteria	F	nucleotide phosphatase activity, acting on free nucleotides	mobA	-	2.7.4.9,2.7.7.77,3.6.1.15,3.6.1.55,3.6.3.29,3.6.3.34	ko:K00943,ko:K02013,ko:K02017,ko:K03574,ko:K03752,ko:K06928	ko00230,ko00240,ko00730,ko00790,ko01100,ko02010,map00230,map00240,map00730,map00790,map01100,map02010	M00053,M00189,M00240	R00086,R00615,R02094,R02098,R11581	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000,ko03400	3.A.1.14,3.A.1.8	-	-	DUF2478,NTPase_1
SX2_k127_816284_4	573413.Spirs_2943	3.55e-55	218.0	COG1120@1|root,COG1120@2|Bacteria,2J5UM@203691|Spirochaetes	203691|Spirochaetes	HP	COGs COG1120 ABC-type cobalamin Fe3 -siderophores transport systems ATPase components	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
SX2_k127_816284_1	1123274.KB899412_gene1444	2.506e-104	348.0	COG0609@1|root,COG0609@2|Bacteria,2J669@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
SX2_k127_816284_3	1499967.BAYZ01000077_gene858	1.096e-71	254.0	COG0614@1|root,COG0614@2|Bacteria	2|Bacteria	P	abc-type fe3 -hydroxamate transport system, periplasmic component	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
SX2_k127_816284_5	1198452.Jab_1c20720	5.827e-29	119.0	COG2314@1|root,COG2314@2|Bacteria,1N8CV@1224|Proteobacteria,2VWM9@28216|Betaproteobacteria	28216|Betaproteobacteria	S	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	TM2
SX2_k127_816284_6	61647.LG71_13775	1.533e-26	113.0	COG2068@1|root,COG2068@2|Bacteria,1QE5N@1224|Proteobacteria,1S3GJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Mo(VI)-molybdopterin cytosine dinucleotide biosynthetic process	ygfJ	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019538,GO:0019637,GO:0019720,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061602,GO:0070567,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902759,GO:1902760	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_3649,iB21_1397.B21_02672,iECABU_c1320.ECABU_c31580,iECBD_1354.ECBD_0860,iECB_1328.ECB_02710,iECD_1391.ECD_02710,iEcHS_1320.EcHS_A3037	NTP_transf_3
SX2_k127_822634_14	518766.Rmar_0925	5.528e-54	202.0	COG1472@1|root,COG1680@1|root,COG1472@2|Bacteria,COG1680@2|Bacteria,4NET8@976|Bacteroidetes,1FJ9E@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Beta-lactamase,Glyco_hydro_3,Glyco_hydro_3_C
SX2_k127_822634_11	697281.Mahau_0032	3.28e-91	334.0	COG0407@1|root,COG0407@2|Bacteria,1V5KX@1239|Firmicutes,24IAR@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX2_k127_822634_13	886293.Sinac_2843	8.713e-79	297.0	COG1680@1|root,COG2173@1|root,COG1680@2|Bacteria,COG2173@2|Bacteria,2IWSU@203682|Planctomycetes	203682|Planctomycetes	MV	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,Peptidase_M15
SX2_k127_822634_10	1089547.KB913013_gene3055	1.199e-93	331.0	COG4948@1|root,COG4948@2|Bacteria,4NEBX@976|Bacteroidetes,47N8Q@768503|Cytophagia	976|Bacteroidetes	M	mandelate racemase muconate lactonizing	-	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0046872,GO:0071704,GO:1901564	5.1.1.20	ko:K19802	-	-	R10938	RC03309	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
SX2_k127_822634_21	118173.KB235914_gene842	2.433e-20	108.0	COG1262@1|root,COG1672@1|root,COG4249@1|root,COG1262@2|Bacteria,COG1672@2|Bacteria,COG4249@2|Bacteria,1G0ZT@1117|Cyanobacteria,1H92Y@1150|Oscillatoriales	1117|Cyanobacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,Peptidase_C14,TIR_2
SX2_k127_822634_28	497965.Cyan7822_1218	0.0002645	52.0	COG1672@1|root,COG1672@2|Bacteria,1G15R@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Archaeal ATPase	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_822634_19	502025.Hoch_3346	9.733e-35	143.0	COG1262@1|root,COG2114@1|root,COG5635@1|root,COG1262@2|Bacteria,COG2114@2|Bacteria,COG5635@2|Bacteria,1R66C@1224|Proteobacteria	1224|Proteobacteria	T	NACHT domain	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,NACHT
SX2_k127_822634_24	867845.KI911784_gene3614	8.93e-16	89.0	COG1672@1|root,COG1672@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K06921	-	-	-	-	ko00000	-	-	-	AAA_16,AAA_22,AAA_35
SX2_k127_822634_0	688269.Theth_1511	4.729e-184	620.0	COG5012@1|root,COG5012@2|Bacteria,2GCEQ@200918|Thermotogae	200918|Thermotogae	S	PFAM cobalamin B12-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Met_asp_mut_E
SX2_k127_822634_5	1047013.AQSP01000075_gene1429	1.473e-119	400.0	COG0240@1|root,COG0240@2|Bacteria	2|Bacteria	I	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity	odh	-	1.5.1.28	ko:K04940	-	-	-	-	ko00000,ko01000	-	-	-	ApbA,F420_oxidored,NAD_Gly3P_dh_N,NAD_binding_2,Octopine_DH
SX2_k127_822634_25	671143.DAMO_1538	2.185e-15	86.0	COG0668@1|root,COG0668@2|Bacteria,2NQ6B@2323|unclassified Bacteria	2|Bacteria	M	transmembrane transport	cmpX	-	-	-	-	-	-	-	-	-	-	-	MS_channel,TM_helix
SX2_k127_822634_22	889378.Spiaf_2775	1.067e-19	102.0	COG3030@1|root,COG3030@2|Bacteria	2|Bacteria	S	protein affecting phage T7 exclusion by the F plasmid	fxsA	-	2.3.3.13	ko:K01649,ko:K07113	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	FxsA
SX2_k127_822634_15	1123274.KB899407_gene351	1.115e-49	194.0	COG1922@1|root,COG1922@2|Bacteria,2J6M5@203691|Spirochaetes	203691|Spirochaetes	M	WecB TagA CpsF family	-	-	2.4.1.187	ko:K05946	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB
SX2_k127_822634_18	545695.TREAZ_2709	3.158e-39	159.0	COG1385@1|root,COG1385@2|Bacteria,2J7WH@203691|Spirochaetes	203691|Spirochaetes	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
SX2_k127_822634_6	1125699.HMPREF9194_02005	1.131e-115	389.0	COG0793@1|root,COG0793@2|Bacteria,2J5QD@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the peptidase S41A family	ctp	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
SX2_k127_822634_17	1396418.BATQ01000154_gene1018	1.076e-41	176.0	COG0785@1|root,COG0785@2|Bacteria	2|Bacteria	O	Cytochrome C biogenesis protein	-	-	-	-	-	-	-	-	-	-	-	-	DsbD,Glutaredoxin,SfLAP
SX2_k127_822634_4	665571.STHERM_c00350	2.502e-120	396.0	COG0682@1|root,COG0682@2|Bacteria,2J58I@203691|Spirochaetes	203691|Spirochaetes	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
SX2_k127_822634_2	118005.AWNK01000006_gene1380	5.734e-165	526.0	COG1104@1|root,COG1104@2|Bacteria	2|Bacteria	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	nifS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
SX2_k127_822634_3	273121.WS2205	1.447e-136	442.0	COG0694@1|root,COG0822@1|root,COG0694@2|Bacteria,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,42MT6@68525|delta/epsilon subdivisions,2YMXY@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	CO	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins	-	-	-	ko:K13819	-	-	-	-	ko00000	-	-	-	Fer2_BFD,NifU,NifU_N
SX2_k127_822634_27	457421.CBFG_01805	1.145e-09	69.0	COG2197@1|root,COG2197@2|Bacteria,1VGRH@1239|Firmicutes,25BMR@186801|Clostridia	186801|Clostridia	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
SX2_k127_822634_23	313598.MED152_12649	6.381e-19	98.0	COG2339@1|root,COG2339@2|Bacteria,4NGUS@976|Bacteroidetes,1HY3J@117743|Flavobacteriia,3VVQ8@52959|Polaribacter	976|Bacteroidetes	S	Protease prsW family	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
SX2_k127_822634_16	292459.STH1644	2.239e-42	171.0	COG1940@1|root,COG1940@2|Bacteria,1TQCE@1239|Firmicutes,24AE3@186801|Clostridia	186801|Clostridia	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,ROK
SX2_k127_822634_1	1499967.BAYZ01000143_gene6121	1.149e-167	539.0	COG0399@1|root,COG0399@2|Bacteria,2NQH7@2323|unclassified Bacteria	2|Bacteria	E	Cys/Met metabolism PLP-dependent enzyme	stsA	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0016051,GO:0043170,GO:0044238,GO:0071704,GO:1901576	2.6.1.109	ko:K19715	-	-	R11395	RC00160	ko00000,ko01000,ko01005	-	-	-	DegT_DnrJ_EryC1
SX2_k127_822634_7	697281.Mahau_2105	1.149e-108	368.0	COG1653@1|root,COG1653@2|Bacteria,1UV5I@1239|Firmicutes,25MFU@186801|Clostridia,42IJ1@68295|Thermoanaerobacterales	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
SX2_k127_822634_8	697281.Mahau_2104	6.942e-107	356.0	COG1175@1|root,COG1175@2|Bacteria,1UYK3@1239|Firmicutes,25C5Y@186801|Clostridia	186801|Clostridia	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
SX2_k127_822634_9	697281.Mahau_2103	7.675e-103	345.0	COG0395@1|root,COG0395@2|Bacteria,1V2Q1@1239|Firmicutes,24A8E@186801|Clostridia	186801|Clostridia	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
SX2_k127_822634_26	632518.Calow_2148	2.543e-11	75.0	COG0407@1|root,COG0407@2|Bacteria,1UY51@1239|Firmicutes,24DZF@186801|Clostridia,42FW9@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX2_k127_822634_20	697281.Mahau_2948	2.378e-33	136.0	COG0407@1|root,COG0407@2|Bacteria,1UY51@1239|Firmicutes,24DZF@186801|Clostridia,42FW9@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX2_k127_822634_29	697281.Mahau_2948	0.0005763	44.0	COG0407@1|root,COG0407@2|Bacteria,1UY51@1239|Firmicutes,24DZF@186801|Clostridia,42FW9@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX2_k127_822634_12	1128421.JAGA01000002_gene377	1.061e-81	280.0	COG1063@1|root,COG1063@2|Bacteria,2NRAB@2323|unclassified Bacteria	2|Bacteria	E	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
SX2_k127_82783_1	1499967.BAYZ01000097_gene4327	4.847e-31	125.0	COG1486@1|root,COG1486@2|Bacteria	2|Bacteria	G	melibiose metabolic process	-	-	3.2.1.22,3.2.1.86	ko:K01222,ko:K07406	ko00010,ko00052,ko00500,ko00561,ko00600,ko00603,map00010,map00052,map00500,map00561,map00600,map00603	-	R00839,R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05133,R05134,R05549,R05961,R06091	RC00049,RC00059,RC00171,RC00451,RC00714	ko00000,ko00001,ko01000	-	GT4	-	Glyco_hydro_4,Glyco_hydro_4C
SX2_k127_82783_0	1499967.BAYZ01000032_gene1131	0.0	1496.0	COG2373@1|root,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1,Thiol-ester_cl
SX2_k127_82783_2	998674.ATTE01000001_gene3590	2.998e-26	113.0	COG4953@1|root,COG4953@2|Bacteria,1MUA9@1224|Proteobacteria,1RMBV@1236|Gammaproteobacteria,463Q4@72273|Thiotrichales	72273|Thiotrichales	M	Penicillin-Binding Protein C-terminus Family	-	-	-	-	-	-	-	-	-	-	-	-	BiPBP_C,Transgly,Transpeptidase
SX2_k127_856807_7	744872.Spica_0661	5.399e-10	66.0	2ANXJ@1|root,31DYA@2|Bacteria,2JB64@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_856807_4	706587.Desti_1456	1.291e-42	173.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,42RHG@68525|delta/epsilon subdivisions,2WQ59@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	prx-4	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
SX2_k127_856807_2	665571.STHERM_c18100	6.119e-55	203.0	COG0300@1|root,COG0300@2|Bacteria,2J5I8@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
SX2_k127_856807_5	411467.BACCAP_02399	2.898e-34	138.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia,268PT@186813|unclassified Clostridiales	186801|Clostridia	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SX2_k127_856807_10	264732.Moth_2363	4.21e-05	53.0	COG5662@1|root,COG5662@2|Bacteria,1VC8Y@1239|Firmicutes,24NRN@186801|Clostridia,42GY2@68295|Thermoanaerobacterales	186801|Clostridia	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349,zf-HC2
SX2_k127_856807_9	1122915.AUGY01000074_gene4319	7.165e-06	57.0	2DS5W@1|root,33EPQ@2|Bacteria,1VMYK@1239|Firmicutes,4HSD8@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_856807_0	1121396.KB893013_gene3675	5.557e-118	389.0	COG0863@1|root,COG0863@2|Bacteria,1R7RV@1224|Proteobacteria,42NFT@68525|delta/epsilon subdivisions,2WJMQ@28221|Deltaproteobacteria,2MJ40@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
SX2_k127_856807_3	880073.Calab_2711	4.188e-45	169.0	COG1443@1|root,COG1443@2|Bacteria,2NQ8N@2323|unclassified Bacteria	2|Bacteria	I	NUDIX domain	yfcD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.7.6.2,5.3.3.2	ko:K00949,ko:K01823	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R00619,R01123	RC00002,RC00017,RC00455	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_0565	NUDIX
SX2_k127_856807_1	1121440.AUMA01000003_gene3071	6.787e-81	278.0	COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,42PTI@68525|delta/epsilon subdivisions,2WIWT@28221|Deltaproteobacteria,2M93E@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
SX2_k127_856807_6	411468.CLOSCI_03045	6.285e-22	100.0	COG1695@1|root,COG1695@2|Bacteria,1V85H@1239|Firmicutes,24N2G@186801|Clostridia,22185@1506553|Lachnoclostridium	186801|Clostridia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
SX2_k127_856807_8	204669.Acid345_1799	1.289e-06	53.0	2DMUF@1|root,32TR1@2|Bacteria,3Y98H@57723|Acidobacteria,2JMXW@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_859873_0	697303.Thewi_2532	4.644e-59	216.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1TQ33@1239|Firmicutes,249TZ@186801|Clostridia,42FCI@68295|Thermoanaerobacterales	186801|Clostridia	L	DNA polymerase	polX	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
SX2_k127_859873_2	1232437.KL661971_gene4829	1.94e-20	105.0	COG4244@1|root,COG4244@2|Bacteria,1NAQT@1224|Proteobacteria,42WQA@68525|delta/epsilon subdivisions,2WRAT@28221|Deltaproteobacteria,2MM5Y@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_859873_1	1123274.KB899433_gene1336	5.892e-31	128.0	COG1438@1|root,COG1438@2|Bacteria,2J7NJ@203691|Spirochaetes	203691|Spirochaetes	K	Regulates arginine biosynthesis genes	argR	-	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
SX2_k127_859873_3	1415778.JQMM01000001_gene2084	4.932e-07	51.0	2DU2E@1|root,33NN7@2|Bacteria,1P5P1@1224|Proteobacteria,1SV3F@1236|Gammaproteobacteria,1JBM0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_875689_11	1122947.FR7_1359	1.056e-13	72.0	COG1082@1|root,COG1082@2|Bacteria,1TPJT@1239|Firmicutes	1239|Firmicutes	G	Xylose isomerase	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
SX2_k127_875689_1	1499967.BAYZ01000067_gene6042	1.477e-184	606.0	COG1070@1|root,COG1070@2|Bacteria	2|Bacteria	G	xylulokinase activity	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
SX2_k127_875689_8	1499967.BAYZ01000067_gene6041	3.286e-73	265.0	COG0274@1|root,COG0274@2|Bacteria,2NP8Z@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
SX2_k127_875689_10	1235798.C817_03636	3.35e-52	194.0	COG2188@1|root,COG2188@2|Bacteria,1UYBW@1239|Firmicutes,24N1N@186801|Clostridia,27X94@189330|Dorea	186801|Clostridia	K	UTRA	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
SX2_k127_875689_2	1499967.BAYZ01000159_gene504	3.092e-146	471.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	1.1.1.370	ko:K16043	ko00562,ko01120,map00562,map01120	-	R09953	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX2_k127_875689_4	1499967.BAYZ01000118_gene3283	1.119e-122	406.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
SX2_k127_875689_0	1499967.BAYZ01000066_gene6056	3.071e-193	633.0	COG1070@1|root,COG1070@2|Bacteria	2|Bacteria	G	xylulokinase activity	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
SX2_k127_875689_7	1499967.BAYZ01000066_gene6054	3.719e-74	254.0	COG2140@1|root,COG2140@2|Bacteria	2|Bacteria	G	oxalate decarboxylase activity	-	-	5.3.1.9	ko:K06859	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Cupin_2,GPI
SX2_k127_875689_6	1499967.BAYZ01000066_gene6053	3.193e-107	357.0	COG0111@1|root,COG0111@2|Bacteria	2|Bacteria	EH	4-phosphoerythronate dehydrogenase activity	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
SX2_k127_875689_3	289377.HL41_02390	1.036e-128	432.0	COG2414@1|root,COG2414@2|Bacteria,2GGWI@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
SX2_k127_875689_5	412597.AEPN01000007_gene1973	6.85e-118	392.0	COG0169@1|root,COG0169@2|Bacteria,1QNXY@1224|Proteobacteria,2TSZT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_875689_9	1122917.KB899663_gene2684	2.712e-60	230.0	COG1349@1|root,COG1349@2|Bacteria,1TSF8@1239|Firmicutes,4HDT9@91061|Bacilli,26T41@186822|Paenibacillaceae	91061|Bacilli	K	transcriptional	-	-	-	ko:K03436	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
SX2_k127_879247_0	1254432.SCE1572_06800	2.188e-73	258.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,42M98@68525|delta/epsilon subdivisions,2WMKB@28221|Deltaproteobacteria,2YXV7@29|Myxococcales	28221|Deltaproteobacteria	L	HTH-like domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve
SX2_k127_879247_1	1242864.D187_008852	8.097e-24	103.0	COG2963@1|root,COG2963@2|Bacteria,1MZ5C@1224|Proteobacteria,42WWI@68525|delta/epsilon subdivisions,2WSR8@28221|Deltaproteobacteria,2Z1X6@29|Myxococcales	28221|Deltaproteobacteria	L	Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
SX2_k127_880981_1	545694.TREPR_2780	1.579e-68	256.0	COG0457@1|root,COG1652@1|root,COG0457@2|Bacteria,COG1652@2|Bacteria,2J7YH@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_880981_0	744872.Spica_2479	4.681e-123	406.0	2AMMU@1|root,31CHX@2|Bacteria,2J7FZ@203691|Spirochaetes	203691|Spirochaetes	S	by glimmer	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_880981_2	545694.TREPR_2435	2.915e-47	194.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,2J6FV@203691|Spirochaetes	203691|Spirochaetes	T	Adenylate guanylate cyclase catalytic domain protein	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
SX2_k127_891155_0	906968.Trebr_1163	2.703e-174	563.0	COG1154@1|root,COG1154@2|Bacteria,2J5NP@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
SX2_k127_891155_1	665571.STHERM_c18380	1.537e-69	244.0	COG0294@1|root,COG0294@2|Bacteria,2J6FQ@203691|Spirochaetes	203691|Spirochaetes	H	dihydropteroate synthase	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
SX2_k127_906304_2	335543.Sfum_1073	2.743e-68	235.0	COG4868@1|root,COG4868@2|Bacteria,1NN03@1224|Proteobacteria,42P46@68525|delta/epsilon subdivisions,2WKVV@28221|Deltaproteobacteria,2MR6J@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1846)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1846
SX2_k127_906304_1	1382356.JQMP01000001_gene1176	1.035e-76	272.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
SX2_k127_906304_3	1521187.JPIM01000022_gene633	2.427e-22	104.0	COG0296@1|root,COG0296@2|Bacteria,2G9SJ@200795|Chloroflexi,377QN@32061|Chloroflexia	32061|Chloroflexia	G	PFAM glycoside hydrolase family 13 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM,CBM_48
SX2_k127_906304_0	794903.OPIT5_07675	1.4e-137	458.0	COG0421@1|root,COG0421@2|Bacteria,46Z5G@74201|Verrucomicrobia,3K91M@414999|Opitutae	414999|Opitutae	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_915218_8	1237149.C900_04169	1.326e-18	96.0	COG3656@1|root,COG5563@1|root,COG3656@2|Bacteria,COG5563@2|Bacteria,4NHDQ@976|Bacteroidetes,47PJR@768503|Cytophagia	976|Bacteroidetes	G	Fibronectin type III domain protein	-	-	-	ko:K21571	-	-	-	-	ko00000	-	-	-	-
SX2_k127_915218_6	452637.Oter_1824	5.291e-35	153.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,PD40
SX2_k127_915218_0	1151119.KB895497_gene3383	8.889e-193	648.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GMN4@201174|Actinobacteria,1W9JV@1268|Micrococcaceae	201174|Actinobacteria	G	pyruvate phosphate dikinase, PEP	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
SX2_k127_915218_5	272558.10173790	3.136e-47	186.0	COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,4HB1V@91061|Bacilli,1ZB90@1386|Bacillus	91061|Bacilli	EGP	COG0477 Permeases of the major facilitator superfamily	-	-	-	ko:K08153	-	M00717	-	-	ko00000,ko00002,ko02000	2.A.1.2.8	-	-	MFS_1,Sugar_tr
SX2_k127_915218_3	1120949.KB903329_gene9217	4.352e-91	332.0	COG2909@1|root,COG2909@2|Bacteria,2IDM6@201174|Actinobacteria,4DCIQ@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,GerE,Pkinase
SX2_k127_915218_9	709797.CSIRO_2012	4.918e-11	65.0	2EIVM@1|root,33CKZ@2|Bacteria,1NG0Q@1224|Proteobacteria,2UHZ9@28211|Alphaproteobacteria,3K1BU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_915218_2	644966.Tmar_1474	1.274e-99	344.0	COG0074@1|root,COG0074@2|Bacteria,1UJ4F@1239|Firmicutes,24AQG@186801|Clostridia	186801|Clostridia	C	Succinyl-CoA synthetase, alpha subunit	-	-	-	ko:K02381	-	-	-	-	ko00000	-	-	-	CoA_binding,Ligase_CoA
SX2_k127_915218_1	1411123.JQNH01000001_gene742	4.481e-118	410.0	COG0074@1|root,COG0074@2|Bacteria,1MX67@1224|Proteobacteria,2U0AT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Protein of unknown function (DUF1116)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1116
SX2_k127_915218_4	1122917.KB899661_gene959	4.689e-81	299.0	COG1744@1|root,COG1744@2|Bacteria,1TPEU@1239|Firmicutes,4HF7R@91061|Bacilli,26QEK@186822|Paenibacillaceae	91061|Bacilli	S	membrane	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
SX2_k127_915218_7	882.DVU_1069	1.828e-32	130.0	COG1079@1|root,COG1079@2|Bacteria,1MVDQ@1224|Proteobacteria,42P6E@68525|delta/epsilon subdivisions,2WISH@28221|Deltaproteobacteria,2M879@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
SX2_k127_936707_0	573413.Spirs_2056	1.811e-227	715.0	COG0539@1|root,COG1098@1|root,COG0539@2|Bacteria,COG1098@2|Bacteria,2J5DZ@203691|Spirochaetes	203691|Spirochaetes	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Cytidylate_kin,S1
SX2_k127_936707_1	221027.JO40_07735	2.616e-156	509.0	COG3829@1|root,COG3829@2|Bacteria,2J63K@203691|Spirochaetes	203691|Spirochaetes	KT	Transcriptional regulator containing GAF AAA-type ATPase and DNA binding domains	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,Sigma54_activat
SX2_k127_936707_3	573413.Spirs_2058	1.699e-25	122.0	COG1729@1|root,COG1729@2|Bacteria,2J7YF@203691|Spirochaetes	203691|Spirochaetes	S	TPR domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_16,TPR_6,TPR_8
SX2_k127_936707_2	665571.STHERM_c10940	1.054e-100	342.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,2J6FV@203691|Spirochaetes	203691|Spirochaetes	T	Adenylate guanylate cyclase catalytic domain protein	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
SX2_k127_957378_2	889378.Spiaf_2104	1.863e-33	129.0	COG1536@1|root,COG1536@2|Bacteria,2J5CI@203691|Spirochaetes	203691|Spirochaetes	N	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliG	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
SX2_k127_957378_1	744872.Spica_1668	1.064e-91	310.0	COG1317@1|root,COG1317@2|Bacteria,2J5KZ@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar assembly protein FliH	fliH	-	-	ko:K02411	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliH
SX2_k127_957378_0	545694.TREPR_2555	4.758e-190	603.0	COG1157@1|root,COG1157@2|Bacteria,2J5IJ@203691|Spirochaetes	203691|Spirochaetes	NU	Flagellar protein export ATPase FliI	fliI	-	3.6.3.14	ko:K02412	ko02040,map02040	-	-	-	ko00000,ko00001,ko01000,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	ATP-synt_ab,ATP-synt_ab_N
SX2_k127_957378_3	545694.TREPR_2554	2.616e-11	72.0	COG2882@1|root,COG2882@2|Bacteria,2J8SK@203691|Spirochaetes	203691|Spirochaetes	N	flagellar export protein FliJ	fliJ	-	-	ko:K02413	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliJ
SX2_k127_981384_0	1123274.KB899407_gene243	1.747e-212	668.0	COG0442@1|root,COG0442@2|Bacteria,2J5HF@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
SX2_k127_981384_3	665571.STHERM_c00260	4.713e-61	218.0	COG5497@1|root,COG5497@2|Bacteria,2J7E8@203691|Spirochaetes	203691|Spirochaetes	S	Predicted secreted protein (DUF2259)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2259
SX2_k127_981384_1	926569.ANT_01870	4.886e-110	376.0	COG2876@1|root,COG2876@2|Bacteria,2G643@200795|Chloroflexi	200795|Chloroflexi	E	PFAM DAHP synthetase I KDSA	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
SX2_k127_981384_4	665571.STHERM_c00280	2.443e-51	190.0	COG0170@1|root,COG0170@2|Bacteria,2J6YY@203691|Spirochaetes	203691|Spirochaetes	I	Phosphatidate cytidylyltransferase	cdsA_1	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_981384_2	383372.Rcas_3436	2.571e-87	299.0	COG2120@1|root,COG2120@2|Bacteria	2|Bacteria	S	N-acetylglucosaminylinositol deacetylase activity	-	-	-	ko:K01463	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
SX2_k127_981384_5	1382304.JNIL01000001_gene2454	1.301e-06	50.0	COG4821@1|root,COG4821@2|Bacteria,1TQS7@1239|Firmicutes,4HCR4@91061|Bacilli	91061|Bacilli	S	protein containing SIS (Sugar ISomerase) phosphosugar binding domain	-	-	-	-	-	-	-	-	-	-	-	-	SIS_2
## 2816 queries scanned
## Total time (seconds): 219.79283905029297
## Rate: 12.81 q/s