## Fri Nov 15 12:39:44 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin24/SX_2_bin.9.fa -m mmseqs --itype genome -o SX_2_bin.9 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/SX_2_bin.9 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
SX2_k127_1019043_1	313612.L8106_02282	4.272e-14	80.0	COG1520@1|root,COG2931@1|root,COG4886@1|root,COG5276@1|root,COG5373@1|root,COG1520@2|Bacteria,COG2931@2|Bacteria,COG4886@2|Bacteria,COG5276@2|Bacteria,COG5373@2|Bacteria,1G1I0@1117|Cyanobacteria,1H84J@1150|Oscillatoriales	1117|Cyanobacteria	Q	RTX toxins and related Ca2 binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347,HemolysinCabind,Peptidase_M10_C
SX2_k127_1019043_0	1125863.JAFN01000001_gene2253	5.11e-108	361.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
SX2_k127_104568_1	391603.FBALC1_14417	6.739e-05	53.0	COG1305@1|root,COG1305@2|Bacteria,4NEKT@976|Bacteroidetes,1HYKS@117743|Flavobacteriia	976|Bacteroidetes	E	Domain of Unknown Function with PDB structure (DUF3857)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,Transglut_core
SX2_k127_104568_0	648996.Theam_0889	1.354e-44	184.0	COG1305@1|root,COG1305@2|Bacteria,2G4Q8@200783|Aquificae	200783|Aquificae	E	Domain of Unknown Function with PDB structure (DUF3857)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,DUF3858,Transglut_core
SX2_k127_1047253_1	386456.JQKN01000015_gene2918	7.016e-67	232.0	COG0115@1|root,arCOG02297@2157|Archaea,2XT9V@28890|Euryarchaeota,23NNK@183925|Methanobacteria	183925|Methanobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
SX2_k127_1047253_0	1379698.RBG1_1C00001G1457	4.56e-118	396.0	COG1960@1|root,COG1960@2|Bacteria,2NNRN@2323|unclassified Bacteria	2|Bacteria	I	Dehydrogenase	acdA	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SX2_k127_1047253_2	1379698.RBG1_1C00001G1458	4.873e-55	196.0	COG1960@1|root,COG1960@2|Bacteria,2NNRN@2323|unclassified Bacteria	2|Bacteria	I	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SX2_k127_1064013_0	675817.VDA_000154	5.21e-64	228.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,1XSYR@135623|Vibrionales	135623|Vibrionales	V	Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX2_k127_1064013_1	1042163.BRLA_c005300	1.378e-11	73.0	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,4HDKX@91061|Bacilli,26SVP@186822|Paenibacillaceae	91061|Bacilli	V	ABC transporter permease	ytrF	-	-	ko:K02004,ko:K16918	ko02010,map02010	M00258,M00584	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX2_k127_1085400_0	880073.Calab_3128	8.074e-10	69.0	2API0@1|root,31EM0@2|Bacteria,2NRTE@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1090688_0	1379698.RBG1_1C00001G0271	5.207e-99	327.0	COG0187@1|root,COG0187@2|Bacteria,2NNSN@2323|unclassified Bacteria	2|Bacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
SX2_k127_1090688_2	290315.Clim_0004	1.06e-11	68.0	COG5512@1|root,COG5512@2|Bacteria,1FE6R@1090|Chlorobi	1090|Chlorobi	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
SX2_k127_1090688_1	1304880.JAGB01000005_gene2437	5.359e-60	221.0	COG1195@1|root,COG1195@2|Bacteria,1TP9U@1239|Firmicutes,247KY@186801|Clostridia	186801|Clostridia	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
SX2_k127_1090688_3	945713.IALB_2117	7.811e-05	55.0	COG4733@1|root,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C10,Phage-tail_3,Prophage_tail,SLH
SX2_k127_109072_5	1191523.MROS_2096	1.163e-13	77.0	COG1410@1|root,COG1410@2|Bacteria	2|Bacteria	E	methionine synthase	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Met_synt_B12
SX2_k127_109072_1	697303.Thewi_2114	1.014e-64	229.0	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia,42FJI@68295|Thermoanaerobacterales	186801|Clostridia	S	Methionine synthase B12-binding module cap domain protein	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
SX2_k127_109072_0	243231.GSU2921	7.298e-71	250.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42NHZ@68525|delta/epsilon subdivisions,2WJ2H@28221|Deltaproteobacteria,43U7R@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Methionine synthase B12-binding module cap domain protein	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
SX2_k127_109072_4	1380394.JADL01000010_gene4317	1.075e-14	87.0	COG0664@1|root,COG0664@2|Bacteria,1N6WV@1224|Proteobacteria,2U63Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
SX2_k127_109072_3	1121428.DESHY_60174___1	9.783e-33	144.0	COG3852@1|root,COG3852@2|Bacteria,1TRH0@1239|Firmicutes,24IAZ@186801|Clostridia,263WT@186807|Peptococcaceae	186801|Clostridia	T	PAS domain	-	-	2.7.13.3	ko:K07710	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9
SX2_k127_109072_6	2423.NA23_0204920	6.032e-06	54.0	2EE08@1|root,337V2@2|Bacteria,2GDJF@200918|Thermotogae	200918|Thermotogae	S	Protein of unknown function (DUF3307)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3307
SX2_k127_109072_2	765420.OSCT_0452	1.246e-44	182.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,2G699@200795|Chloroflexi,3766E@32061|Chloroflexia	32061|Chloroflexia	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,TPR_12
SX2_k127_1094695_0	1379698.RBG1_1C00001G0103	4.842e-161	525.0	COG0060@1|root,COG0060@2|Bacteria,2NNT5@2323|unclassified Bacteria	2|Bacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
SX2_k127_1094695_1	1379698.RBG1_1C00001G0104	2.614e-44	165.0	COG1734@1|root,COG1734@2|Bacteria,2NPX2@2323|unclassified Bacteria	2|Bacteria	T	Transcriptional regulator, TraR DksA family	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
SX2_k127_1094695_2	555079.Toce_1014	1.814e-19	92.0	COG0597@1|root,COG0597@2|Bacteria,1VA9R@1239|Firmicutes,24QPP@186801|Clostridia,42GTZ@68295|Thermoanaerobacterales	186801|Clostridia	M	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
SX2_k127_1095720_3	1379698.RBG1_1C00001G0500	3.366e-06	57.0	COG0823@1|root,COG0823@2|Bacteria,2NNZC@2323|unclassified Bacteria	2|Bacteria	U	TolB amino-terminal domain	tolB	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009719,GO:0009987,GO:0010033,GO:0010243,GO:0015031,GO:0015833,GO:0015893,GO:0017038,GO:0019534,GO:0019904,GO:0022857,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0032991,GO:0033036,GO:0042221,GO:0042493,GO:0042597,GO:0042886,GO:0042891,GO:0043213,GO:0044464,GO:0044877,GO:0045184,GO:0046677,GO:0046678,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070887,GO:0071236,GO:0071237,GO:0071310,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1901998	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
SX2_k127_1095720_2	1379698.RBG1_1C00001G0499	5.598e-18	92.0	COG0810@1|root,COG0810@2|Bacteria,2NQ3G@2323|unclassified Bacteria	2|Bacteria	M	TonB C terminal	-	-	-	ko:K03646,ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1,2.C.1.2	-	-	CarbopepD_reg_2,TonB_2,TonB_C
SX2_k127_1095720_1	1379698.RBG1_1C00001G0498	8.818e-32	129.0	COG0848@1|root,COG0848@2|Bacteria,2NPWJ@2323|unclassified Bacteria	2|Bacteria	U	Biopolymer transport protein ExbD/TolR	tolR	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
SX2_k127_1095720_0	1304885.AUEY01000054_gene164	1.971e-32	129.0	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,42PKF@68525|delta/epsilon subdivisions,2WNQ4@28221|Deltaproteobacteria,2MHWF@213118|Desulfobacterales	28221|Deltaproteobacteria	U	PFAM MotA TolQ ExbB proton channel	aglX	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
SX2_k127_1095869_3	1379698.RBG1_1C00001G1178	6.887e-72	252.0	COG0240@1|root,COG0240@2|Bacteria,2NP1N@2323|unclassified Bacteria	2|Bacteria	I	Glycerol-3-phosphate dehydrogenase	gpsA	GO:0003674,GO:0003824,GO:0004367,GO:0006072,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0046167,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901576	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
SX2_k127_1095869_6	1379698.RBG1_1C00001G1179	1.65e-41	160.0	COG0344@1|root,COG0344@2|Bacteria,2NPME@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
SX2_k127_1095869_8	1381123.AYOD01000001_gene868	1.198e-32	134.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,2U749@28211|Alphaproteobacteria,43JVE@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	Ribosomal protein L17	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
SX2_k127_1095869_0	1379698.RBG1_1C00001G1568	4.888e-126	411.0	COG0202@1|root,COG0202@2|Bacteria,2NNQQ@2323|unclassified Bacteria	2|Bacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
SX2_k127_1095869_2	1379698.RBG1_1C00001G1569	4.457e-83	281.0	COG0522@1|root,COG0522@2|Bacteria,2NPCC@2323|unclassified Bacteria	2|Bacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	GO:0000028,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006417,GO:0006446,GO:0006450,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010629,GO:0015935,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030371,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031554,GO:0031564,GO:0032268,GO:0032269,GO:0032270,GO:0032991,GO:0034248,GO:0034249,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043244,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0045727,GO:0045903,GO:0045947,GO:0048027,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0065008,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990145,GO:1990904,GO:2000112,GO:2000113,GO:2001141	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
SX2_k127_1095869_4	1379698.RBG1_1C00001G1570	2.535e-56	198.0	COG0100@1|root,COG0100@2|Bacteria,2NPCN@2323|unclassified Bacteria	2|Bacteria	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
SX2_k127_1095869_5	1379698.RBG1_1C00001G1571	8.921e-53	188.0	COG0099@1|root,COG0099@2|Bacteria,2NPKH@2323|unclassified Bacteria	2|Bacteria	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
SX2_k127_1095869_9	754252.PFREUD_06030	1.977e-12	67.0	COG0257@1|root,COG0257@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
SX2_k127_1095869_7	1379698.RBG1_1C00001G1573	1.539e-37	141.0	COG0361@1|root,COG0361@2|Bacteria,2NPNU@2323|unclassified Bacteria	2|Bacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
SX2_k127_1095869_1	1487923.DP73_05965	3.202e-83	282.0	COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,248I8@186801|Clostridia,260SK@186807|Peptococcaceae	186801|Clostridia	E	TIGRFAM methionine aminopeptidase, type I	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
SX2_k127_1117680_0	1379698.RBG1_1C00001G0518	7.917e-118	406.0	COG0515@1|root,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,TPR_2,TPR_8
SX2_k127_112638_1	909663.KI867150_gene401	5.453e-40	154.0	COG1905@1|root,COG1905@2|Bacteria,1RHBU@1224|Proteobacteria,42U8S@68525|delta/epsilon subdivisions,2WQ8V@28221|Deltaproteobacteria,2MQIE@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	nuoE-1	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
SX2_k127_112638_0	386456.JQKN01000009_gene1128	5.927e-191	608.0	COG1894@1|root,COG2221@1|root,arCOG02059@2157|Archaea,arCOG04537@2157|Archaea,2XUYN@28890|Euryarchaeota	28890|Euryarchaeota	C	NADH ubiquinone oxidoreductase, NADH-binding (51 kD) subunit	-	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
SX2_k127_1134126_2	1191523.MROS_2373	6.547e-16	83.0	COG0839@1|root,COG0839@2|Bacteria	2|Bacteria	C	Belongs to the complex I subunit 6 family	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
SX2_k127_1134126_1	1122194.AUHU01000005_gene1111	2.769e-27	119.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,1RN32@1236|Gammaproteobacteria,466PB@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	e_coli_core.b2281,iAF1260.b2281,iAPECO1_1312.APECO1_4284,iB21_1397.B21_02166,iBWG_1329.BWG_2055,iE2348C_1286.E2348C_2421,iEC042_1314.EC042_2522,iEC55989_1330.EC55989_2525,iECABU_c1320.ECABU_c26130,iECBD_1354.ECBD_1380,iECB_1328.ECB_02206,iECDH10B_1368.ECDH10B_2443,iECDH1ME8569_1439.ECDH1ME8569_2218,iECD_1391.ECD_02206,iECED1_1282.ECED1_2745,iECH74115_1262.ECH74115_3420,iECIAI1_1343.ECIAI1_2355,iECIAI39_1322.ECIAI39_2428,iECNA114_1301.ECNA114_2371,iECO103_1326.ECO103_2745,iECO111_1330.ECO111_3029,iECO26_1355.ECO26_3269,iECOK1_1307.ECOK1_2514,iECP_1309.ECP_2320,iECS88_1305.ECS88_2428,iECSE_1348.ECSE_2538,iECSF_1327.ECSF_2158,iECSP_1301.ECSP_3155,iECUMN_1333.ECUMN_2620,iECW_1372.ECW_m2469,iECs_1301.ECs3165,iEKO11_1354.EKO11_1486,iETEC_1333.ETEC_2416,iEcDH1_1363.EcDH1_1376,iEcE24377_1341.EcE24377A_2574,iEcHS_1320.EcHS_A2430,iEcSMS35_1347.EcSMS35_2435,iEcolC_1368.EcolC_1371,iG2583_1286.G2583_2818,iJO1366.b2281,iJR904.b2281,iLF82_1304.LF82_1546,iNRG857_1313.NRG857_11550,iPC815.YPO2548,iSBO_1134.SBO_2314,iSFV_1184.SFV_2348,iSF_1195.SF2357,iSFxv_1172.SFxv_2601,iS_1188.S2492,iSbBS512_1146.SbBS512_E2657,iUMN146_1321.UM146_05410,iUMNK88_1353.UMNK88_2831,iUTI89_1310.UTI89_C2561,iWFL_1372.ECW_m2469,iY75_1357.Y75_RS11960,iZ_1308.Z3540,ic_1306.c2822	Fer4
SX2_k127_1134126_0	1449126.JQKL01000022_gene115	1.751e-76	260.0	COG1005@1|root,COG1005@2|Bacteria,1TQNU@1239|Firmicutes,25E6Z@186801|Clostridia	186801|Clostridia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
SX2_k127_1137776_2	1380600.AUYN01000006_gene338	4.66e-39	154.0	COG2885@1|root,COG2885@2|Bacteria,4NI3U@976|Bacteroidetes,1I04E@117743|Flavobacteriia	976|Bacteroidetes	M	Belongs to the ompA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OmpA
SX2_k127_1137776_0	443143.GM18_2363	8.71e-80	273.0	COG0730@1|root,COG0730@2|Bacteria,1MXNM@1224|Proteobacteria,42KZF@68525|delta/epsilon subdivisions,2WPGW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
SX2_k127_1137776_3	1249997.JHZW01000002_gene1581	1.052e-06	60.0	COG4775@1|root,COG4775@2|Bacteria,4NGAM@976|Bacteroidetes,1HX00@117743|Flavobacteriia,2PGWX@252356|Maribacter	976|Bacteroidetes	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	POTRA
SX2_k127_1139761_0	158189.SpiBuddy_2758	9.71e-21	95.0	COG0469@1|root,COG0469@2|Bacteria,2J5VE@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
SX2_k127_1139761_1	1068978.AMETH_3482	2.882e-18	90.0	COG3324@1|root,COG3324@2|Bacteria,2IRXF@201174|Actinobacteria	201174|Actinobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
SX2_k127_1139761_2	909613.UO65_0728	2.86e-09	66.0	COG3832@1|root,COG3832@2|Bacteria,2GNVY@201174|Actinobacteria,4E2JC@85010|Pseudonocardiales	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
SX2_k127_1144917_0	247490.KSU1_D0742	1.424e-147	475.0	COG0365@1|root,COG0365@2|Bacteria,2IX5P@203682|Planctomycetes	203682|Planctomycetes	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
SX2_k127_1144917_2	886293.Sinac_1596	6.811e-09	60.0	COG0236@1|root,COG0236@2|Bacteria,2J1MP@203682|Planctomycetes	203682|Planctomycetes	IQ	acyl carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
SX2_k127_1144917_1	391625.PPSIR1_26968	1.214e-84	286.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,42MM1@68525|delta/epsilon subdivisions,2WIU7@28221|Deltaproteobacteria,2YU40@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA	kbl	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
SX2_k127_1148724_1	1191523.MROS_1655	3.607e-21	95.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,HisKA_7TM,Hpt,PMT_2,Response_reg
SX2_k127_1148724_0	1379698.RBG1_1C00001G0352	1.768e-48	190.0	COG0457@1|root,COG0457@2|Bacteria,2NRR4@2323|unclassified Bacteria	2|Bacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
SX2_k127_1153358_0	1382356.JQMP01000001_gene867	2.019e-74	261.0	COG0318@1|root,COG0318@2|Bacteria,2G7PF@200795|Chloroflexi,27XJD@189775|Thermomicrobia	189775|Thermomicrobia	IQ	Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily	menE	-	6.2.1.26	ko:K01911	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04030	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	AMP-binding,AMP-binding_C
SX2_k127_1153358_1	716544.wcw_0460	2.071e-25	113.0	COG0824@1|root,COG0824@2|Bacteria,2JG70@204428|Chlamydiae	204428|Chlamydiae	S	Acyl-ACP thioesterase	-	-	3.1.2.28	ko:K12073	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07262	RC00004,RC00174	ko00000,ko00001,ko00002,ko01000	-	-	-	4HBT_2
SX2_k127_118139_0	1379698.RBG1_1C00001G1108	5.529e-98	326.0	COG1191@1|root,COG1191@2|Bacteria,2NPMN@2323|unclassified Bacteria	2|Bacteria	K	Sigma-70 region 3	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
SX2_k127_1203173_2	1089553.Tph_c11050	2.671e-08	64.0	COG5581@1|root,COG5581@2|Bacteria,1VERW@1239|Firmicutes,24NU7@186801|Clostridia,42GFE@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM type IV pilus assembly PilZ	pilZ	-	-	-	-	-	-	-	-	-	-	-	PilZ,YcgR_2
SX2_k127_1203553_2	1382356.JQMP01000004_gene264	8.745e-32	135.0	COG0558@1|root,COG0558@2|Bacteria,2G7HQ@200795|Chloroflexi,27YAM@189775|Thermomicrobia	189775|Thermomicrobia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
SX2_k127_1203553_0	555079.Toce_2076	2.747e-58	206.0	COG0454@1|root,COG0456@2|Bacteria,1V6D6@1239|Firmicutes,24KC1@186801|Clostridia,42GT3@68295|Thermoanaerobacterales	186801|Clostridia	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SX2_k127_1203553_1	644282.Deba_0444	2.521e-35	140.0	COG0569@1|root,COG0569@2|Bacteria,1R7KM@1224|Proteobacteria,42PJH@68525|delta/epsilon subdivisions,2WMZT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM TrkA-N domain protein	ktrA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
SX2_k127_1207084_2	945713.IALB_0238	1.951e-36	140.0	COG4274@1|root,COG4274@2|Bacteria	2|Bacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
SX2_k127_1207084_0	1047013.AQSP01000139_gene2416	3.191e-97	339.0	COG1404@1|root,COG1404@2|Bacteria,2NNSK@2323|unclassified Bacteria	2|Bacteria	O	Subtilase family	aprN	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
SX2_k127_1207084_1	751945.Theos_0766	4.509e-40	154.0	COG0045@1|root,COG0045@2|Bacteria,1WIT1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
SX2_k127_121453_0	1379698.RBG1_1C00001G1698	8.571e-86	287.0	COG0031@1|root,COG0031@2|Bacteria,2NP1M@2323|unclassified Bacteria	2|Bacteria	E	Pyridoxal-phosphate dependent enzyme	cysK	-	2.5.1.47,4.2.1.22	ko:K01697,ko:K01738	ko00260,ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00035,M00338	R00891,R00897,R01290,R03601,R04859,R04942	RC00020,RC00056,RC00069,RC00256,RC00489,RC01246,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
SX2_k127_121453_1	1382306.JNIM01000001_gene289	3.057e-40	157.0	COG1028@1|root,COG1028@2|Bacteria	1382306.JNIM01000001_gene289|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1218270_0	1379698.RBG1_1C00001G1510	1.985e-92	318.0	COG0312@1|root,COG0312@2|Bacteria,2NP7I@2323|unclassified Bacteria	2|Bacteria	S	Putative modulator of DNA gyrase	tldE2	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
SX2_k127_1235381_1	882.DVU_0740	8.483e-53	199.0	COG0477@1|root,COG2814@2|Bacteria,1P2GY@1224|Proteobacteria,42MWI@68525|delta/epsilon subdivisions,2WK29@28221|Deltaproteobacteria,2M97V@213115|Desulfovibrionales	28221|Deltaproteobacteria	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX2_k127_1235381_3	1462527.CCDM010000007_gene156	0.000238	52.0	COG0454@1|root,COG0456@2|Bacteria,1V3NF@1239|Firmicutes,4HH7Y@91061|Bacilli,23KH1@182709|Oceanobacillus	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_7
SX2_k127_1235381_0	234267.Acid_0852	1.294e-54	199.0	COG2834@1|root,COG2834@2|Bacteria	2|Bacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4292
SX2_k127_1238197_0	1379698.RBG1_1C00001G1368	1.193e-59	214.0	COG4219@1|root,COG4219@2|Bacteria,2NS3V@2323|unclassified Bacteria	2|Bacteria	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_6,DUF4309,DUF5301
SX2_k127_1238197_1	1379698.RBG1_1C00001G1369	1.354e-14	82.0	COG4219@1|root,COG4219@2|Bacteria,2NR11@2323|unclassified Bacteria	2|Bacteria	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_6,DUF4309,DUF5301
SX2_k127_1238969_2	243231.GSU2606	1.323e-06	57.0	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,42N01@68525|delta/epsilon subdivisions,2WKJQ@28221|Deltaproteobacteria,43TXZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
SX2_k127_1238969_1	880073.Calab_0837	1.73e-78	279.0	COG0534@1|root,COG0534@2|Bacteria,2NPBA@2323|unclassified Bacteria	2|Bacteria	V	MATE efflux family protein	mepA_10	-	-	-	-	-	-	-	-	-	-	-	MatE
SX2_k127_1238969_0	1131269.AQVV01000008_gene912	3.42e-84	289.0	COG0123@1|root,COG0123@2|Bacteria	2|Bacteria	BQ	including yeast histone deacetylase and acetoin utilization protein	acuC	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
SX2_k127_1238977_0	558152.IQ37_15445	2.129e-05	53.0	COG3522@1|root,COG3522@2|Bacteria,4NGBP@976|Bacteroidetes,1HZZS@117743|Flavobacteriia,3ZPGJ@59732|Chryseobacterium	976|Bacteroidetes	S	type VI secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1238977_1	758.BBIX01000008_gene1278	0.0002463	52.0	COG3520@1|root,COG3520@2|Bacteria,1MWVS@1224|Proteobacteria,1RQD5@1236|Gammaproteobacteria,1Y9KW@135625|Pasteurellales	135625|Pasteurellales	S	Pfam:T6SS_VasB	-	-	-	ko:K11895	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	T6SS_TssG
SX2_k127_1244825_2	1379698.RBG1_1C00001G1860	8.126e-89	295.0	COG1077@1|root,COG1077@2|Bacteria,2NNVU@2323|unclassified Bacteria	2|Bacteria	D	MreB/Mbl protein	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
SX2_k127_1244825_3	247490.KSU1_C1165	1.927e-70	247.0	COG0388@1|root,COG0388@2|Bacteria,2IXKW@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.6	ko:K01431	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R00905,R04666,R08228	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase
SX2_k127_1244825_1	1379698.RBG1_1C00001G1238	6.511e-119	408.0	COG5000@1|root,COG5000@2|Bacteria,2NQEP@2323|unclassified Bacteria	2|Bacteria	T	COGs COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,dCache_1
SX2_k127_1244825_0	1379698.RBG1_1C00001G1481	5.742e-135	449.0	COG0358@1|root,COG0358@2|Bacteria,2NNNJ@2323|unclassified Bacteria	2|Bacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
SX2_k127_1270089_1	1379698.RBG1_1C00001G1092	1.328e-12	79.0	COG2866@1|root,COG4412@1|root,COG2866@2|Bacteria,COG4412@2|Bacteria,2NPI7@2323|unclassified Bacteria	2|Bacteria	E	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	3.4.17.18,3.4.17.22	ko:K05996,ko:K07752	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	F5_F8_type_C,Peptidase_M14,Peptidase_M6,Ricin_B_lectin,fn3
SX2_k127_1270089_2	1232437.KL662061_gene4159	2.801e-08	60.0	COG5652@1|root,COG5652@2|Bacteria,1NB26@1224|Proteobacteria,42VNM@68525|delta/epsilon subdivisions,2WS4R@28221|Deltaproteobacteria,2MM1X@213118|Desulfobacterales	28221|Deltaproteobacteria	S	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
SX2_k127_1270089_0	1379698.RBG1_1C00001G0635	8.314e-37	143.0	COG1089@1|root,COG1089@2|Bacteria,2NNM2@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
SX2_k127_12723_0	880073.Calab_0681	2.578e-124	422.0	COG2172@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,2NP51@2323|unclassified Bacteria	2|Bacteria	KT	Sigma factor PP2C-like phosphatases	pkn5	-	2.7.11.1,3.1.3.3	ko:K04757,ko:K07315	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	AAA_16,GAF,HAMP,HATPase_c_2,Pkinase,SpoIIE,dCache_1
SX2_k127_1283138_0	218284.CCDN010000002_gene2017	1.338e-33	144.0	COG3227@1|root,COG3227@2|Bacteria,1TP08@1239|Firmicutes,4H9S6@91061|Bacilli,1ZCEP@1386|Bacillus	91061|Bacilli	E	Peptidase M4	npr	GO:0005575,GO:0005576	3.4.24.28	ko:K01400	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	FTP,PepSY,Peptidase_M4,Peptidase_M4_C
SX2_k127_1294387_0	111780.Sta7437_4371	0.000452	51.0	COG1196@1|root,COG2911@1|root,COG1196@2|Bacteria,COG2911@2|Bacteria,1GQRE@1117|Cyanobacteria	1117|Cyanobacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1307502_1	706587.Desti_2759	1.842e-09	60.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIPT@28221|Deltaproteobacteria,2MS08@213462|Syntrophobacterales	28221|Deltaproteobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	nuoL-1	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
SX2_k127_1307502_0	1379698.RBG1_1C00001G1061	5.407e-227	713.0	COG1008@1|root,COG1008@2|Bacteria,2NNQ9@2323|unclassified Bacteria	2|Bacteria	C	NADH-quinone oxidoreductase, chain M	nuoM-1	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
SX2_k127_1307553_2	696747.NIES39_C00810	0.0001034	53.0	COG0457@1|root,COG0457@2|Bacteria,1G29N@1117|Cyanobacteria,1H92V@1150|Oscillatoriales	1117|Cyanobacteria	G	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF563,Methyltransf_24,Sulfotransfer_1,TPR_1,TPR_11,TPR_16,TPR_2,TPR_7,TPR_8
SX2_k127_1307553_1	675635.Psed_4874	3.049e-28	119.0	COG3324@1|root,COG3324@2|Bacteria,2IRXF@201174|Actinobacteria	201174|Actinobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
SX2_k127_1307553_0	941824.TCEL_00879	5.154e-80	267.0	COG0432@1|root,COG0432@2|Bacteria,1V201@1239|Firmicutes,24FTY@186801|Clostridia,36IW8@31979|Clostridiaceae	186801|Clostridia	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
SX2_k127_1311939_0	1379698.RBG1_1C00001G0186	0.0	1237.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2NNNY@2323|unclassified Bacteria	2|Bacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.3.13,2.7.9.1	ko:K01006,ko:K22424	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
SX2_k127_1311939_1	204669.Acid345_2966	2.958e-75	259.0	COG2079@1|root,COG2079@2|Bacteria,3Y5N1@57723|Acidobacteria,2JK64@204432|Acidobacteriia	204432|Acidobacteriia	S	MmgE/PrpD family	-	-	4.2.1.79	ko:K01720	ko00640,map00640	-	R04424	RC01152	ko00000,ko00001,ko01000	-	-	-	MmgE_PrpD
SX2_k127_1323524_0	1379698.RBG1_1C00001G0417	3.082e-115	384.0	COG1198@1|root,COG1198@2|Bacteria,2NNQ3@2323|unclassified Bacteria	2|Bacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
SX2_k127_1323524_1	1379698.RBG1_1C00001G0377	8.742e-12	67.0	COG3294@1|root,COG3294@2|Bacteria,2NQWX@2323|unclassified Bacteria	2|Bacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K09163	-	-	-	-	ko00000	-	-	-	HD
SX2_k127_1349889_2	880073.Calab_3748	3.519e-07	59.0	2E919@1|root,333AJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1349889_1	518766.Rmar_0713	5.511e-09	66.0	2EGU2@1|root,33AK8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1349889_3	880073.Calab_0086	1.572e-05	58.0	2EUGM@1|root,33MYV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1349889_0	1379698.RBG1_1C00001G0320	3.41e-56	205.0	COG0030@1|root,COG0030@2|Bacteria,2NPDT@2323|unclassified Bacteria	2|Bacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528,ko:K15256	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009,ko03016	-	-	-	Methyltransf_21,RrnaAD
SX2_k127_135855_2	1382304.JNIL01000001_gene557	8.661e-05	46.0	COG0612@1|root,COG0612@2|Bacteria,1TP5I@1239|Firmicutes,4HBBF@91061|Bacilli,279JD@186823|Alicyclobacillaceae	91061|Bacilli	S	Belongs to the peptidase M16 family	mlpA	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
SX2_k127_135855_1	1379698.RBG1_1C00001G1162	1.1e-35	146.0	COG0726@1|root,COG0726@2|Bacteria,2NPY1@2323|unclassified Bacteria	2|Bacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Polysacc_deac_1
SX2_k127_135855_0	1379698.RBG1_1C00001G1163	3.934e-112	368.0	COG0017@1|root,COG0017@2|Bacteria,2NNQM@2323|unclassified Bacteria	2|Bacteria	J	tRNA synthetases class II (D, K and N)	asnS	GO:0003674,GO:0003824,GO:0004812,GO:0004816,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006421,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
SX2_k127_1359826_0	370438.PTH_1386	2.876e-125	410.0	COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,249AM@186801|Clostridia,2607Y@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA2	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
SX2_k127_1374784_0	1379698.RBG1_1C00001G1656	4.558e-283	885.0	COG0653@1|root,COG0653@2|Bacteria,2NNRK@2323|unclassified Bacteria	2|Bacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
SX2_k127_1387767_1	552811.Dehly_0763	3.889e-104	347.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2G8XD@200795|Chloroflexi,34CY9@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
SX2_k127_1387767_2	1121937.AUHJ01000009_gene1566	2.91e-63	220.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,1S3PD@1236|Gammaproteobacteria,468KZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015075,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
SX2_k127_1387767_3	933262.AXAM01000021_gene472	1.471e-44	167.0	COG0615@1|root,COG0615@2|Bacteria,1REW3@1224|Proteobacteria,42SGQ@68525|delta/epsilon subdivisions,2WPTP@28221|Deltaproteobacteria,2MJTC@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	rfaE	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like
SX2_k127_1387767_0	1379698.RBG1_1C00001G1511	2.805e-155	500.0	COG0312@1|root,COG0312@2|Bacteria,2NPIS@2323|unclassified Bacteria	2|Bacteria	S	Putative modulator of DNA gyrase	tldD2	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
SX2_k127_1390411_1	1379698.RBG1_1C00001G1136	4.91e-15	79.0	COG2956@1|root,COG2956@2|Bacteria	2|Bacteria	G	lipopolysaccharide metabolic process	ciaB	-	-	ko:K07502,ko:K08309,ko:K19804,ko:K21572	-	-	-	-	ko00000,ko01000,ko01011,ko02000	8.A.46.1,8.A.46.3	GH23	-	SusD-like_3,SusD_RagB,TPR_16,TPR_6,TPR_8
SX2_k127_1390411_2	880073.Calab_1441	2.465e-09	63.0	COG4447@1|root,COG4447@2|Bacteria,2NQ6W@2323|unclassified Bacteria	2|Bacteria	S	Por secretion system C-terminal sorting domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	FlgD_ig,Sortilin-Vps10
SX2_k127_139226_0	945713.IALB_2321	8.082e-114	385.0	COG0308@1|root,COG0308@2|Bacteria	2|Bacteria	E	peptide catabolic process	pepN1	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
SX2_k127_1403283_1	391587.KAOT1_06552	0.000144	50.0	COG4856@1|root,COG4856@2|Bacteria,4NHJQ@976|Bacteroidetes,1I0BY@117743|Flavobacteriia	976|Bacteroidetes	S	YbbR-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
SX2_k127_1403283_0	880073.Calab_3414	3.27e-85	291.0	COG0533@1|root,COG0533@2|Bacteria,2NNXP@2323|unclassified Bacteria	2|Bacteria	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564	2.3.1.234	ko:K01409,ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	R10648	RC00070,RC00416	ko00000,ko00001,ko00002,ko01000,ko02044,ko03016	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Peptidase_M22
SX2_k127_141100_0	1009370.ALO_04968	6.334e-125	420.0	COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,4H20U@909932|Negativicutes	909932|Negativicutes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
SX2_k127_141100_1	1379698.RBG1_1C00001G1766	7.338e-98	340.0	COG4365@1|root,COG4365@2|Bacteria,2NP8Q@2323|unclassified Bacteria	2|Bacteria	S	Bacillithiol biosynthesis BshC	bshC	-	-	ko:K22136	-	-	-	-	ko00000	-	-	-	BshC
SX2_k127_141100_2	1379698.RBG1_1C00001G1765	1.482e-93	312.0	COG0438@1|root,COG0438@2|Bacteria,2NNTN@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferases group 1	bshA	GO:0003674,GO:0003824,GO:0016740,GO:0016757	-	ko:K00754	-	-	-	-	ko00000,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1
SX2_k127_1414006_3	272134.KB731324_gene5884	3.083e-28	118.0	COG0778@1|root,COG0778@2|Bacteria,1G5XK@1117|Cyanobacteria,1HE79@1150|Oscillatoriales	1117|Cyanobacteria	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SX2_k127_1414006_2	1379698.RBG1_1C00001G1716	1.846e-72	261.0	COG0544@1|root,COG0544@2|Bacteria,2NPBN@2323|unclassified Bacteria	2|Bacteria	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
SX2_k127_1414006_0	1158318.ATXC01000001_gene1441	5.507e-87	292.0	COG0740@1|root,COG0740@2|Bacteria,2G3IM@200783|Aquificae	200783|Aquificae	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
SX2_k127_1414006_1	1111134.HMPREF1253_1254	4.911e-83	280.0	COG1219@1|root,COG1219@2|Bacteria,1TQ00@1239|Firmicutes,2481T@186801|Clostridia,22G9C@1570339|Peptoniphilaceae	186801|Clostridia	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
SX2_k127_1414560_0	96561.Dole_0322	5.338e-29	131.0	COG0457@1|root,COG1462@1|root,COG0457@2|Bacteria,COG1462@2|Bacteria,1QW0P@1224|Proteobacteria,431MA@68525|delta/epsilon subdivisions,2WWRG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1415051_0	471854.Dfer_1052	2.051e-05	57.0	COG0457@1|root,COG1729@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,4NE4W@976|Bacteroidetes,47JS4@768503|Cytophagia	976|Bacteroidetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_21,TPR_6,TPR_8
SX2_k127_1422025_0	880073.Calab_1379	2.628e-129	421.0	COG1186@1|root,COG1186@2|Bacteria,2NNU3@2323|unclassified Bacteria	2|Bacteria	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
SX2_k127_1422025_1	2325.TKV_c13970	1.409e-107	359.0	COG0280@1|root,COG0280@2|Bacteria,1TPQ0@1239|Firmicutes,247W9@186801|Clostridia,42EZE@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Phosphate acetyl butaryl transferase	pta	GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.8	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	PTA_PTB
SX2_k127_1423218_0	552811.Dehly_0559	3.846e-173	553.0	COG0174@1|root,COG0174@2|Bacteria,2G5U2@200795|Chloroflexi,34CUT@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Glutamine synthetase, catalytic domain	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
SX2_k127_1423218_1	1379698.RBG1_1C00001G0088	1.508e-05	51.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	pal	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	CarboxypepD_reg,OmpA,PD40
SX2_k127_1433407_1	1234364.AMSF01000061_gene2084	5.682e-32	141.0	COG0793@1|root,COG0793@2|Bacteria,1N4T9@1224|Proteobacteria,1SE36@1236|Gammaproteobacteria,1X70X@135614|Xanthomonadales	135614|Xanthomonadales	M	Aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,PDZ_2
SX2_k127_1433407_2	1385521.N803_09860	1.243e-24	113.0	COG0584@1|root,COG0584@2|Bacteria,2GJ5W@201174|Actinobacteria,4FEDS@85021|Intrasporangiaceae	201174|Actinobacteria	C	Glycerophosphoryl diester phosphodiesterase family	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
SX2_k127_1433407_0	706587.Desti_0471	1.961e-90	303.0	COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,42MTN@68525|delta/epsilon subdivisions,2WJAI@28221|Deltaproteobacteria,2MQUJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rmlA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
SX2_k127_1459836_0	1379698.RBG1_1C00001G1385	3.457e-48	181.0	COG3391@1|root,COG3391@2|Bacteria,2NQ7V@2323|unclassified Bacteria	2|Bacteria	S	Lactonase, 7-bladed beta-propeller	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	Cytochrom_D1,Exo_endo_phos,He_PIG,LTD,Lactonase
SX2_k127_1459836_1	1379698.RBG1_1C00001G1384	9.933e-37	151.0	COG4206@1|root,COG4206@2|Bacteria,2NPT3@2323|unclassified Bacteria	2|Bacteria	H	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
SX2_k127_1464977_1	1379698.RBG1_1C00001G1524	1.111e-14	79.0	COG2911@1|root,COG2911@2|Bacteria,2NQ89@2323|unclassified Bacteria	2|Bacteria	S	TamB, inner membrane protein subunit of TAM complex	-	-	-	ko:K07277,ko:K09800	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	AsmA_2,DUF748,TamB
SX2_k127_1464977_0	1379698.RBG1_1C00001G1523	2.024e-19	100.0	COG4775@1|root,COG4775@2|Bacteria,2NQXR@2323|unclassified Bacteria	2|Bacteria	M	Surface antigen	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
SX2_k127_1483188_1	278963.ATWD01000001_gene3270	1.867e-17	84.0	COG0776@1|root,COG0776@2|Bacteria,3Y50P@57723|Acidobacteria,2JJJ5@204432|Acidobacteriia	204432|Acidobacteriia	L	Belongs to the bacterial histone-like protein family	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
SX2_k127_1483188_2	604331.AUHY01000027_gene554	9.182e-05	55.0	COG0457@1|root,COG0457@2|Bacteria,1WI76@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
SX2_k127_1483188_0	886293.Sinac_6637	2.144e-47	175.0	COG1163@1|root,COG1163@2|Bacteria,2IWYP@203682|Planctomycetes	203682|Planctomycetes	S	TGS domain	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,TGS
SX2_k127_1483342_1	553184.ATORI0001_0215	1.962e-12	70.0	COG0816@1|root,COG0816@2|Bacteria,2HGE5@201174|Actinobacteria,4CW3E@84998|Coriobacteriia	84998|Coriobacteriia	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
SX2_k127_1483342_0	933262.AXAM01000030_gene807	2.302e-58	216.0	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,42MPA@68525|delta/epsilon subdivisions,2WJ0Q@28221|Deltaproteobacteria,2MI3R@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
SX2_k127_1489141_2	1379698.RBG1_1C00001G0643	1.374e-111	367.0	COG0462@1|root,COG0462@2|Bacteria,2NNP6@2323|unclassified Bacteria	2|Bacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	GO:0003674,GO:0003824,GO:0004749,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2848	Pribosyl_synth,Pribosyltran_N
SX2_k127_1489141_1	1121930.AQXG01000004_gene2955	2.559e-137	449.0	COG0104@1|root,COG0104@2|Bacteria,4NGRZ@976|Bacteroidetes,1IQYP@117747|Sphingobacteriia	976|Bacteroidetes	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
SX2_k127_1489141_3	1151292.QEW_3950	1.14e-44	168.0	COG0218@1|root,COG0218@2|Bacteria,1TSPW@1239|Firmicutes,24836@186801|Clostridia,25QD6@186804|Peptostreptococcaceae	186801|Clostridia	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
SX2_k127_1489141_0	555088.DealDRAFT_1048	8.53e-192	614.0	COG0466@1|root,COG0466@2|Bacteria,1TNYG@1239|Firmicutes,247SH@186801|Clostridia,42JPA@68298|Syntrophomonadaceae	186801|Clostridia	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
SX2_k127_1505689_0	926550.CLDAP_31550	3.689e-147	486.0	COG4579@1|root,COG4579@2|Bacteria	2|Bacteria	F	[isocitrate dehydrogenase (NADP+)] phosphatase activity	aceK	GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004721,GO:0004722,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009060,GO:0009987,GO:0015980,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0016999,GO:0017076,GO:0017144,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046487,GO:0050790,GO:0055114,GO:0065007,GO:0065009,GO:0070262,GO:0071704,GO:0072350,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.11.5	ko:K00906	-	-	-	-	ko00000,ko01000	-	-	-	AceK
SX2_k127_1505689_1	1131462.DCF50_p892	1.01e-61	218.0	COG1853@1|root,COG1853@2|Bacteria,1V41U@1239|Firmicutes,24HTA@186801|Clostridia,26732@186807|Peptococcaceae	186801|Clostridia	S	Conserved protein of DIM6 NTAB family	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
SX2_k127_1506915_0	1379698.RBG1_1C00001G1332	3.692e-48	182.0	COG1366@1|root,COG1366@2|Bacteria,2NR50@2323|unclassified Bacteria	2|Bacteria	T	Anti-sigma factor antagonist	-	-	-	ko:K04749,ko:K06378	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
SX2_k127_1506915_1	502025.Hoch_4669	3.12e-47	179.0	COG1192@1|root,COG1192@2|Bacteria,1QW1T@1224|Proteobacteria,43BRW@68525|delta/epsilon subdivisions,2X72Q@28221|Deltaproteobacteria,2YZTD@29|Myxococcales	28221|Deltaproteobacteria	D	Cellulose biosynthesis protein BcsQ	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
SX2_k127_1509604_0	1379698.RBG1_1C00001G0868	8.109e-46	176.0	COG0741@1|root,COG0741@2|Bacteria,2NPKN@2323|unclassified Bacteria	2|Bacteria	M	Transglycosylase SLT domain	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,TPR_16,TPR_6
SX2_k127_1509604_1	1379698.RBG1_1C00001G0869	4.044e-10	64.0	COG4105@1|root,COG4105@2|Bacteria,2NPZ3@2323|unclassified Bacteria	2|Bacteria	S	Outer membrane lipoprotein	yfiO	-	-	ko:K05807,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02000	1.B.33.1	GH23	-	YfiO
SX2_k127_1517378_0	1379698.RBG1_1C00001G1131	3.112e-84	297.0	COG0497@1|root,COG0497@2|Bacteria,2NNUS@2323|unclassified Bacteria	2|Bacteria	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631,ko:K07459,ko:K20345	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000,ko03400	3.A.1.112,8.A.1	-	-	SMC_N,YkyA
SX2_k127_1518223_0	880073.Calab_0005	1.291e-211	677.0	COG0317@1|root,COG0317@2|Bacteria,2NNM0@2323|unclassified Bacteria	2|Bacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
SX2_k127_1518223_3	1191523.MROS_0323	9.361e-13	75.0	COG4235@1|root,COG4235@2|Bacteria	2|Bacteria	O	cytochrome complex assembly	-	-	-	ko:K02200,ko:K04018	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_19,TPR_2,TPR_8
SX2_k127_1518223_2	720554.Clocl_4104	5.355e-28	124.0	COG1040@1|root,COG1040@2|Bacteria,1VF2G@1239|Firmicutes,24IG6@186801|Clostridia,3WKFF@541000|Ruminococcaceae	186801|Clostridia	S	Phosphoribosyl transferase domain	comF	-	-	ko:K02242	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	Pribosyltran
SX2_k127_1518223_1	667014.Thein_2038	2.732e-34	137.0	COG4974@1|root,COG4974@2|Bacteria,2GGT8@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	Phage integrase, N-terminal SAM-like domain	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
SX2_k127_1537565_0	1379698.RBG1_1C00001G1788	8.313e-164	552.0	COG2067@1|root,COG3292@1|root,COG2067@2|Bacteria,COG3292@2|Bacteria,2NPQZ@2323|unclassified Bacteria	2|Bacteria	I	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,Reg_prop,Reprolysin_5,VCBS
SX2_k127_1537565_1	1379698.RBG1_1C00001G1789	2.711e-49	185.0	COG1572@1|root,COG1572@2|Bacteria,2NP03@2323|unclassified Bacteria	2|Bacteria	S	Propeptide_C25	porU	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C25
SX2_k127_1545854_5	1120950.KB892783_gene316	0.0001537	54.0	COG1404@1|root,COG3386@1|root,COG1404@2|Bacteria,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	bpr	GO:0005575,GO:0005576	-	ko:K13276,ko:K14274	ko00040,map00040	-	R02427	RC00713	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Inhibitor_I9,Malectin,PKD,Peptidase_M6,Peptidase_S8,SGL
SX2_k127_1545854_0	388467.A19Y_2320	4.035e-100	339.0	COG1085@1|root,COG1085@2|Bacteria,1G1CA@1117|Cyanobacteria,1H82Z@1150|Oscillatoriales	1117|Cyanobacteria	C	galactose-1-phosphate	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf,HIT
SX2_k127_1545854_3	28444.JODQ01000002_gene4195	2.648e-18	96.0	COG0392@1|root,COG0392@2|Bacteria,2IC25@201174|Actinobacteria,4EHA8@85012|Streptosporangiales	201174|Actinobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
SX2_k127_1545854_1	1379698.RBG1_1C00001G0995	3.618e-95	341.0	COG5617@1|root,COG5617@2|Bacteria,2NS5H@2323|unclassified Bacteria	2|Bacteria	E	Bacterial membrane protein YfhO	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
SX2_k127_1545854_2	1379698.RBG1_1C00001G0996	5.437e-37	141.0	COG0463@1|root,COG0463@2|Bacteria,2NS3Y@2323|unclassified Bacteria	2|Bacteria	M	Glycosyltransferase like family 2	dpm1	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
SX2_k127_1549148_0	1379698.RBG1_1C00001G0705	1.298e-97	334.0	COG0760@1|root,COG0760@2|Bacteria,2NPFB@2323|unclassified Bacteria	2|Bacteria	O	PPIC-type PPIASE domain	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,SurA_N_3
SX2_k127_1549148_2	944481.JAFP01000001_gene55	1.889e-15	79.0	COG1188@1|root,COG1188@2|Bacteria,1Q5X3@1224|Proteobacteria,42VKA@68525|delta/epsilon subdivisions,2X55N@28221|Deltaproteobacteria,2M7CW@213113|Desulfurellales	28221|Deltaproteobacteria	J	S4 RNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	S4
SX2_k127_1549148_1	696281.Desru_2823	1.863e-18	88.0	COG2262@1|root,COG2262@2|Bacteria,1TNZB@1239|Firmicutes,248IU@186801|Clostridia,2606G@186807|Peptococcaceae	186801|Clostridia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
SX2_k127_1556502_1	309801.trd_1360	1.885e-31	126.0	COG2353@1|root,COG2353@2|Bacteria,2G6G9@200795|Chloroflexi,27Y8W@189775|Thermomicrobia	189775|Thermomicrobia	S	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
SX2_k127_1556502_0	530564.Psta_0192	2.105e-187	598.0	COG2317@1|root,COG2317@2|Bacteria,2IXSU@203682|Planctomycetes	203682|Planctomycetes	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
SX2_k127_1560488_0	880073.Calab_3754	5.427e-39	168.0	COG3536@1|root,COG3536@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF971)	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1569828_3	1227499.C493_09233	0.0002463	52.0	arCOG08110@1|root,arCOG08110@2157|Archaea,2XUWV@28890|Euryarchaeota,23S8I@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1569828_0	933262.AXAM01000021_gene456	4.013e-109	372.0	COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,42Y69@68525|delta/epsilon subdivisions,2WJ5F@28221|Deltaproteobacteria,2MI66@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF_2,HTH_8,Sigma54_activat
SX2_k127_1569828_1	545695.TREAZ_3182	1.213e-61	220.0	COG2227@1|root,COG2227@2|Bacteria,2J59U@203691|Spirochaetes	203691|Spirochaetes	H	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
SX2_k127_1569828_2	1235799.C818_02946	5.136e-12	66.0	COG0381@1|root,COG0381@2|Bacteria,1TQZT@1239|Firmicutes,247N7@186801|Clostridia,27JBU@186928|unclassified Lachnospiraceae	186801|Clostridia	M	UDP-N-acetylglucosamine 2-epimerase	-	-	5.1.3.14,5.1.3.23	ko:K01791,ko:K13019	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420,R09600	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
SX2_k127_1578945_0	1121468.AUBR01000034_gene1358	1.255e-222	699.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,42FIA@68295|Thermoanaerobacterales	186801|Clostridia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
SX2_k127_1578945_1	1379698.RBG1_1C00001G1474	9.142e-57	200.0	COG2185@1|root,COG2185@2|Bacteria,2NPGA@2323|unclassified Bacteria	2|Bacteria	I	Cobalamin B12-binding	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
SX2_k127_1584473_0	1232410.KI421415_gene3122	2.973e-44	169.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WK1B@28221|Deltaproteobacteria,43S4A@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	ABC1 family	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,APH
SX2_k127_1584473_1	1041930.Mtc_0968	2.29e-34	138.0	arCOG00787@1|root,arCOG00787@2157|Archaea	2157|Archaea	L	UvrD REP helicase	-	-	3.6.4.12	ko:K03657,ko:K07465	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
SX2_k127_1602933_0	330214.NIDE2410	4.993e-121	398.0	COG0673@1|root,COG1063@1|root,COG0673@2|Bacteria,COG1063@2|Bacteria,3J0WC@40117|Nitrospirae	40117|Nitrospirae	C	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N,GFO_IDH_MocA
SX2_k127_1602933_1	1385519.N801_12870	2.509e-33	142.0	COG0438@1|root,COG0438@2|Bacteria,2GMXE@201174|Actinobacteria,4FF5E@85021|Intrasporangiaceae	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
SX2_k127_160489_0	1379698.RBG1_1C00001G0287	1.167e-156	513.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K14986	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9
SX2_k127_160489_1	234267.Acid_2121	8.073e-32	140.0	COG0515@1|root,COG0515@2|Bacteria	234267.Acid_2121|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
SX2_k127_1627790_0	1379698.RBG1_1C00001G0436	6.084e-69	246.0	COG2234@1|root,COG2234@2|Bacteria,2NP7A@2323|unclassified Bacteria	2|Bacteria	S	Peptidase M28	ywaD	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
SX2_k127_1635138_4	1170562.Cal6303_4060	1.37e-17	82.0	COG1770@1|root,COG1770@2|Bacteria,1G1RH@1117|Cyanobacteria,1HJDI@1161|Nostocales	1117|Cyanobacteria	E	PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
SX2_k127_1635138_2	589924.Ferp_1111	1.609e-52	196.0	COG0428@1|root,arCOG00576@2157|Archaea,2XXNC@28890|Euryarchaeota,246ZF@183980|Archaeoglobi	183980|Archaeoglobi	P	PFAM zinc iron permease	-	-	-	ko:K16267	-	-	-	-	ko00000,ko02000	2.A.5.4.11	-	-	Zip
SX2_k127_1635138_0	300852.55772917	5.599e-214	674.0	COG0473@1|root,COG0473@2|Bacteria,1WIRG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Isocitrate isopropylmalate dehydrogenase	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
SX2_k127_1635138_3	1122933.JNIY01000004_gene2456	7.115e-49	181.0	COG0041@1|root,COG0041@2|Bacteria,2IFFD@201174|Actinobacteria,4F154@85016|Cellulomonadaceae	201174|Actinobacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	GO:0008150,GO:0040007	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3275c	AIRC
SX2_k127_1635138_1	107635.AZUO01000001_gene1701	3.523e-71	246.0	COG1453@1|root,COG1453@2|Bacteria,1NIR6@1224|Proteobacteria,2U135@28211|Alphaproteobacteria,36ZIH@31993|Methylocystaceae	28211|Alphaproteobacteria	S	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
SX2_k127_1642331_2	589924.Ferp_0438	4.234e-17	82.0	COG2361@1|root,arCOG05024@2157|Archaea,2Y6HF@28890|Euryarchaeota,246HB@183980|Archaeoglobi	183980|Archaeoglobi	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
SX2_k127_1642331_3	1121930.AQXG01000001_gene1251	6.812e-11	68.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
SX2_k127_1642331_1	1379698.RBG1_1C00001G1413	1.473e-29	123.0	COG4968@1|root,COG4968@2|Bacteria	2|Bacteria	NU	Prokaryotic N-terminal methylation motif	pilE	-	-	ko:K02650,ko:K02655	ko02020,map02020	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.15.2	-	-	ComP_DUS,N_methyl
SX2_k127_1642331_0	1158345.JNLL01000001_gene1749	5.331e-53	194.0	COG0125@1|root,COG0125@2|Bacteria,2G3YA@200783|Aquificae	200783|Aquificae	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
SX2_k127_1644413_1	204669.Acid345_0770	3.713e-41	157.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	2.7.11.1	ko:K08282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_16,TPR_2,TPR_8
SX2_k127_1644413_0	1379698.RBG1_1C00001G1517	6.953e-93	315.0	COG0482@1|root,COG0482@2|Bacteria,2NNPW@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
SX2_k127_1653607_0	398767.Glov_1032	2.087e-163	525.0	COG2252@1|root,COG2252@2|Bacteria,1MUV0@1224|Proteobacteria,42MAE@68525|delta/epsilon subdivisions,2WKFF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Xanthine uracil vitamin C permease	pbuG	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
SX2_k127_1663263_1	1379698.RBG1_1C00001G1119	1.269e-85	290.0	COG0016@1|root,COG0016@2|Bacteria,2NNNT@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
SX2_k127_1663263_3	429009.Adeg_0536	6.678e-40	151.0	COG0292@1|root,COG0292@2|Bacteria,1V6DB@1239|Firmicutes,24JBJ@186801|Clostridia,42GJ4@68295|Thermoanaerobacterales	186801|Clostridia	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
SX2_k127_1663263_2	1379698.RBG1_1C00001G1116	8.209e-64	224.0	COG0290@1|root,COG0290@2|Bacteria,2NPDH@2323|unclassified Bacteria	2|Bacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
SX2_k127_1663263_0	880073.Calab_3708	2.488e-136	441.0	COG0441@1|root,COG0441@2|Bacteria,2NNMT@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
SX2_k127_1670583_3	926560.KE387023_gene3675	2.557e-15	76.0	COG0149@1|root,COG0149@2|Bacteria,1WI59@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
SX2_k127_1670583_2	1379698.RBG1_1C00001G1012	2.479e-21	98.0	COG1314@1|root,COG1314@2|Bacteria,2NQ7S@2323|unclassified Bacteria	2|Bacteria	U	Preprotein translocase SecG subunit	secG	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
SX2_k127_1670583_0	401526.TcarDRAFT_0628	3.02e-99	338.0	COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,4H2W0@909932|Negativicutes	909932|Negativicutes	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
SX2_k127_1670583_1	1347369.CCAD010000055_gene4202	1.19e-24	112.0	COG0169@1|root,COG0169@2|Bacteria,1TQRY@1239|Firmicutes,4HD4R@91061|Bacilli,1ZANW@1386|Bacillus	91061|Bacilli	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
SX2_k127_1685316_3	338963.Pcar_2487	5.111e-17	93.0	COG1032@1|root,COG1032@2|Bacteria,1Q5NG@1224|Proteobacteria,42V17@68525|delta/epsilon subdivisions,2WRD3@28221|Deltaproteobacteria,43UGE@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
SX2_k127_1685316_1	748449.Halha_1713	7.658e-121	409.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia	186801|Clostridia	V	ABC transporter	-	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SX2_k127_1685316_0	1379698.RBG1_1C00001G1351	1.13e-138	451.0	COG0683@1|root,COG0683@2|Bacteria,2NPSN@2323|unclassified Bacteria	2|Bacteria	E	Receptor family ligand binding region	livJ	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
SX2_k127_1685316_2	1396141.BATP01000057_gene3028	6.08e-20	91.0	COG0559@1|root,COG0559@2|Bacteria,46UCA@74201|Verrucomicrobia,2IVC6@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
SX2_k127_1695774_0	234267.Acid_1726	9.057e-12	67.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria	2|Bacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12
SX2_k127_1695774_1	1280692.AUJL01000002_gene2679	1.53e-10	69.0	COG1595@1|root,COG1595@2|Bacteria,1V3PA@1239|Firmicutes,24HAV@186801|Clostridia,36K2Q@31979|Clostridiaceae	186801|Clostridia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SX2_k127_1725563_1	330214.NIDE2288	2.307e-66	241.0	COG1766@1|root,COG1766@2|Bacteria,3J0A6@40117|Nitrospirae	40117|Nitrospirae	N	The M ring may be actively involved in energy transduction	fliF	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
SX2_k127_1725563_0	484770.UFO1_2581	1.254e-104	349.0	COG1536@1|root,COG1536@2|Bacteria,1TP01@1239|Firmicutes,4H3MM@909932|Negativicutes	909932|Negativicutes	N	flagellar motor switch protein FliG	fliG	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
SX2_k127_1739433_0	1379698.RBG1_1C00001G1048	3.936e-286	893.0	COG1205@1|root,COG1205@2|Bacteria,2NNKJ@2323|unclassified Bacteria	2|Bacteria	L	Domain of unknown function (DUF1998)	yprA	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
SX2_k127_1739433_1	1379698.RBG1_1C00001G1047	2.286e-41	158.0	COG1913@1|root,COG1913@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
SX2_k127_1739433_2	756272.Plabr_4441	0.0002962	43.0	2EPX9@1|root,33HHS@2|Bacteria,2J4DJ@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1753415_0	370438.PTH_1770	1.568e-185	591.0	COG2368@1|root,COG2368@2|Bacteria,1TQ70@1239|Firmicutes,248RP@186801|Clostridia,26067@186807|Peptococcaceae	186801|Clostridia	Q	PFAM 4-hydroxyphenylacetate 3-hydroxylase N terminal	-	-	1.14.14.9,4.2.1.120,5.3.3.3	ko:K00483,ko:K14534	ko00350,ko00650,ko00720,ko01100,ko01120,ko01200,ko01220,map00350,map00650,map00720,map01100,map01120,map01200,map01220	M00374,M00375	R02698,R03031,R03299,R10782	RC00046,RC01857,RC03277	ko00000,ko00001,ko00002,ko01000	-	-	-	HpaB,HpaB_N
SX2_k127_1753415_1	555079.Toce_0227	3.994e-38	145.0	COG3829@1|root,COG3829@2|Bacteria,1VBSS@1239|Firmicutes	1239|Firmicutes	KT	transcription factor binding	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1756466_0	1379698.RBG1_1C00001G1141	4.593e-26	118.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,2NP1D@2323|unclassified Bacteria	2|Bacteria	M	Transglycosylase SLT domain	CP_0155	-	-	ko:K08307,ko:K12204	-	-	-	-	ko00000,ko01000,ko01011,ko02044	3.A.7.10.1,3.A.7.9.1	-	-	LysM,SLT,T4SS_TraI
SX2_k127_1756466_1	1379698.RBG1_1C00001G1142	3.686e-06	51.0	COG0616@1|root,COG0616@2|Bacteria,2NPIE@2323|unclassified Bacteria	2|Bacteria	OU	Peptidase family S49	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
SX2_k127_1768204_1	1423734.JCM14202_850	8.966e-10	61.0	COG0707@1|root,COG0707@2|Bacteria,1TQFT@1239|Firmicutes,4HBAQ@91061|Bacilli,3F4FW@33958|Lactobacillaceae	91061|Bacilli	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
SX2_k127_1768204_0	1379698.RBG1_1C00001G0397	1.64e-158	512.0	COG0773@1|root,COG0773@2|Bacteria,2NNPU@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the MurCDEF family	murC	GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iECP_1309.ECP_0093,iJN678.murC	Mur_ligase,Mur_ligase_C,Mur_ligase_M
SX2_k127_1769938_0	290397.Adeh_2260	2.422e-153	494.0	COG1143@1|root,COG1143@2|Bacteria,1QYG4@1224|Proteobacteria,43E88@68525|delta/epsilon subdivisions,2X7N9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_1785990_0	368407.Memar_1603	9.605e-38	152.0	COG0438@1|root,arCOG01411@2157|Archaea,2Y3MP@28890|Euryarchaeota	28890|Euryarchaeota	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SX2_k127_1795603_4	570967.JMLV01000006_gene224	5.563e-06	50.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,2TREC@28211|Alphaproteobacteria,2JPQM@204441|Rhodospirillales	204441|Rhodospirillales	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
SX2_k127_1795603_1	28115.HR11_09720	7.168e-54	195.0	COG0245@1|root,COG0245@2|Bacteria,4NP0N@976|Bacteroidetes,2FNVA@200643|Bacteroidia,22XNK@171551|Porphyromonadaceae	976|Bacteroidetes	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
SX2_k127_1795603_2	1379698.RBG1_1C00001G0839	5.455e-49	184.0	COG1211@1|root,COG1211@2|Bacteria,2NPPY@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567	2.7.7.60,4.6.1.12	ko:K00991,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS20335	IspD
SX2_k127_1795603_0	1158318.ATXC01000001_gene1459	2.087e-94	322.0	COG0809@1|root,COG0809@2|Bacteria,2G3KG@200783|Aquificae	200783|Aquificae	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
SX2_k127_1795603_3	880073.Calab_2591	2.67e-39	148.0	COG2255@1|root,COG2255@2|Bacteria,2NNUG@2323|unclassified Bacteria	2|Bacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
SX2_k127_1796239_0	1379698.RBG1_1C00001G0659	0.0	1375.0	COG0178@1|root,COG0178@2|Bacteria,2NNT3@2323|unclassified Bacteria	2|Bacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
SX2_k127_1796239_1	1110502.TMO_2484	4.516e-05	48.0	COG0454@1|root,COG0456@2|Bacteria,1Q65W@1224|Proteobacteria,2VCDJ@28211|Alphaproteobacteria,2JUPJ@204441|Rhodospirillales	204441|Rhodospirillales	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SX2_k127_179759_1	926562.Oweho_0117	9.483e-54	209.0	COG0457@1|root,COG3307@1|root,COG0457@2|Bacteria,COG3307@2|Bacteria,4NJNB@976|Bacteroidetes,1I16M@117743|Flavobacteriia,2PBT5@246874|Cryomorphaceae	976|Bacteroidetes	M	O-Antigen ligase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2,TPR_8,Wzy_C
SX2_k127_179759_0	880073.Calab_3776	8.008e-56	198.0	COG0621@1|root,COG0621@2|Bacteria,2NNUN@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035597,GO:0035600,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
SX2_k127_1798173_3	945713.IALB_2995	1.759e-08	66.0	COG4288@1|root,COG4288@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,Big_5,CHU_C,FlgD_ig,LTD
SX2_k127_1798173_1	386456.JQKN01000012_gene1046	6.862e-46	171.0	COG0778@1|root,arCOG00288@2157|Archaea,2XZHP@28890|Euryarchaeota	28890|Euryarchaeota	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
SX2_k127_1798173_0	1379698.RBG1_1C00001G1526	4.655e-60	217.0	2CBA8@1|root,30BZT@2|Bacteria,2NR2H@2323|unclassified Bacteria	2|Bacteria	S	Exopolysaccharide biosynthesis protein YbjH	-	-	-	-	-	-	-	-	-	-	-	-	YjbH
SX2_k127_1798173_2	945713.IALB_2070	4.304e-09	62.0	COG2067@1|root,COG2067@2|Bacteria	2|Bacteria	I	long-chain fatty acid transporting porin activity	-	-	-	-	-	-	-	-	-	-	-	-	TraF_2
SX2_k127_1799775_0	1379698.RBG1_1C00001G1275	1.678e-84	295.0	COG3852@1|root,COG3852@2|Bacteria,2NS4D@2323|unclassified Bacteria	2|Bacteria	T	Signal transduction histidine kinase, nitrogen specific, NtrB	atoS	-	2.7.13.3	ko:K07708,ko:K07710,ko:K10942	ko02020,ko05111,map02020,map05111	M00497,M00500,M00515	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_8,PAS_9
SX2_k127_1799775_1	1379270.AUXF01000002_gene1691	9.621e-05	51.0	2F57Y@1|root,33XUE@2|Bacteria,1ZTSK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_182381_2	926566.Terro_1533	6.585e-05	52.0	COG1331@1|root,COG1331@2|Bacteria,3Y3AA@57723|Acidobacteria,2JISJ@204432|Acidobacteriia	204432|Acidobacteriia	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
SX2_k127_182381_0	1173024.KI912149_gene5439	4.925e-34	135.0	COG3339@1|root,COG3339@2|Bacteria,1G7DF@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
SX2_k127_182381_1	926562.Oweho_1278	3.593e-08	61.0	COG0739@1|root,COG0739@2|Bacteria,4NED7@976|Bacteroidetes,1HXKD@117743|Flavobacteriia,2PBIT@246874|Cryomorphaceae	976|Bacteroidetes	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
SX2_k127_1826873_2	880073.Calab_0885	1.371e-64	231.0	COG4974@1|root,COG4974@2|Bacteria,2NP4H@2323|unclassified Bacteria	2|Bacteria	L	Phage integrase, N-terminal SAM-like domain	xerC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
SX2_k127_1826873_1	880073.Calab_0162	1.202e-68	238.0	COG5405@1|root,COG5405@2|Bacteria,2NP72@2323|unclassified Bacteria	2|Bacteria	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016787,GO:0017076,GO:0019538,GO:0019904,GO:0022607,GO:0030163,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0051603,GO:0065003,GO:0070003,GO:0070011,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
SX2_k127_1826873_0	880073.Calab_0163	4.841e-91	305.0	COG1220@1|root,COG1220@2|Bacteria,2NP00@2323|unclassified Bacteria	2|Bacteria	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
SX2_k127_1827611_0	1379698.RBG1_1C00001G1627	2.642e-156	498.0	COG0465@1|root,COG0465@2|Bacteria,2NNQ5@2323|unclassified Bacteria	2|Bacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
SX2_k127_1827611_1	1382315.JPOI01000001_gene790	1.38e-27	115.0	COG0294@1|root,COG0294@2|Bacteria,1TPKT@1239|Firmicutes,4H9SY@91061|Bacilli,1WF9Y@129337|Geobacillus	91061|Bacilli	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
SX2_k127_1828565_0	1379698.RBG1_1C00001G0069	6.986e-64	236.0	COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,2NRP6@2323|unclassified Bacteria	2|Bacteria	O	Subtilase family	-	-	-	ko:K13276	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	CHU_C,FlgD_ig,PKD,Peptidase_S8
SX2_k127_1833082_0	593117.TGAM_0923	6.771e-48	176.0	COG0537@1|root,arCOG00419@2157|Archaea,2XWGT@28890|Euryarchaeota,242M1@183968|Thermococci	183968|Thermococci	F	Hit family	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
SX2_k127_1833082_1	862517.HMPREF9225_1843	5.137e-15	89.0	COG0419@1|root,COG0419@2|Bacteria,1UI2P@1239|Firmicutes,25EBC@186801|Clostridia,22J71@1570339|Peptoniphilaceae	186801|Clostridia	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_23,AAA_27
SX2_k127_1833082_2	1203566.HMPREF1285_02236	4.504e-10	70.0	COG0420@1|root,COG0420@2|Bacteria,2HQKD@201174|Actinobacteria,22KH3@1653|Corynebacteriaceae	201174|Actinobacteria	L	DNA repair exonuclease	sbcD	-	-	-	-	-	-	-	-	-	-	-	Metallophos
SX2_k127_1844836_3	273068.TTE1432	9.141e-16	79.0	COG1582@1|root,COG1582@2|Bacteria,1VKHB@1239|Firmicutes,24RWI@186801|Clostridia,42H8U@68295|Thermoanaerobacterales	186801|Clostridia	N	PFAM flagellar	flbD	-	-	ko:K02385	-	-	-	-	ko00000,ko02035	-	-	-	FlbD
SX2_k127_1844836_0	1313304.CALK_1067	1.471e-101	354.0	COG1749@1|root,COG1749@2|Bacteria	2|Bacteria	N	bacterial-type flagellum-dependent cell motility	flgE	GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	DUF3370,FlaE,Flg_bb_rod,Flg_bbr_C
SX2_k127_1844836_2	1089553.Tph_c10900	9.738e-18	89.0	2E35U@1|root,32Y5R@2|Bacteria,1VEH9@1239|Firmicutes,24R2S@186801|Clostridia,42H81@68295|Thermoanaerobacterales	186801|Clostridia	N	flagellar operon protein	flg	-	-	-	-	-	-	-	-	-	-	-	Flagellar_put
SX2_k127_1844836_4	1469948.JPNB01000001_gene1920	3.208e-07	58.0	COG3144@1|root,COG3144@2|Bacteria,1VAP1@1239|Firmicutes,24RF8@186801|Clostridia,36NI7@31979|Clostridiaceae	186801|Clostridia	N	PFAM Flagellar hook-length control protein	fliK	-	-	ko:K02414	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_hook
SX2_k127_1844866_6	1126627.BAWE01000006_gene6618	6.479e-10	63.0	COG2963@1|root,COG2963@2|Bacteria,1N2T5@1224|Proteobacteria,2U9CF@28211|Alphaproteobacteria,3JZF6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
SX2_k127_1844866_0	1242864.D187_008851	9.201e-86	293.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,42M98@68525|delta/epsilon subdivisions,2WMKB@28221|Deltaproteobacteria,2YXV7@29|Myxococcales	28221|Deltaproteobacteria	L	HTH-like domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve,rve_3
SX2_k127_1844866_5	497965.Cyan7822_0074	7.691e-12	73.0	COG1040@1|root,COG1040@2|Bacteria	2|Bacteria	K	competence protein	comFC	-	-	ko:K02242	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	Pribosyltran
SX2_k127_1844866_1	1379698.RBG1_1C00001G0664	4.376e-58	213.0	COG0758@1|root,COG0758@2|Bacteria,2NP2V@2323|unclassified Bacteria	2|Bacteria	LU	DNA recombination-mediator protein A	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
SX2_k127_1844866_2	309807.SRU_1184	1.115e-41	160.0	COG1739@1|root,COG1739@2|Bacteria,4NF0D@976|Bacteroidetes,1FJ9B@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Domain of unknown function (DUF1949)	yigZ	-	-	-	-	-	-	-	-	-	-	-	UPF0029
SX2_k127_1844866_3	880073.Calab_2990	7.053e-31	128.0	COG0671@1|root,COG0671@2|Bacteria,2NPZ6@2323|unclassified Bacteria	2|Bacteria	I	Phosphoesterase, PA-phosphatase related	-	-	3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27	ko:K01096,ko:K19302	ko00550,ko00564,ko01100,map00550,map00564,map01100	-	R02029,R05627	RC00002,RC00017	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
SX2_k127_1844866_4	945713.IALB_1423	5.539e-14	83.0	COG3206@1|root,COG3206@2|Bacteria	2|Bacteria	M	extracellular polysaccharide biosynthetic process	-	-	3.1.21.3	ko:K01153,ko:K07011,ko:K16554	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko02000,ko02048	8.A.3.1	-	-	GNVR,Wzz
SX2_k127_18477_0	1379698.RBG1_1C00001G0675	3.086e-75	261.0	COG1748@1|root,COG1748@2|Bacteria,2NPF8@2323|unclassified Bacteria	2|Bacteria	E	Saccharopine dehydrogenase C-terminal domain	lysDH	-	1.4.1.18	ko:K19064	ko00960,ko01100,ko01110,map00960,map01100,map01110	-	R00446,R02317	RC00062,RC00694	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,Sacchrp_dh_C,Sacchrp_dh_NADP
SX2_k127_18477_1	1209072.ALBT01000031_gene1835	2.293e-15	81.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,1RN0E@1236|Gammaproteobacteria,1FFXB@10|Cellvibrio	1236|Gammaproteobacteria	M	Biotin-lipoyl like	macA	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
SX2_k127_1850397_1	926561.KB900620_gene3023	7.482e-16	83.0	COG1516@1|root,COG1516@2|Bacteria,1VA8K@1239|Firmicutes,24MRW@186801|Clostridia	186801|Clostridia	N	flagellar protein flis	fliS	-	-	ko:K02422	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliS
SX2_k127_1850397_0	1125863.JAFN01000001_gene217	1.98e-25	111.0	COG1345@1|root,COG1345@2|Bacteria,1MUVP@1224|Proteobacteria,42MHW@68525|delta/epsilon subdivisions,2WNU5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	N	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end	fliD	-	-	ko:K02407	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_IN,FliD_C,FliD_N
SX2_k127_1889627_1	1121324.CLIT_24c00190	1.973e-30	125.0	COG4359@1|root,COG4359@2|Bacteria,1TSZ9@1239|Firmicutes,24IHI@186801|Clostridia	186801|Clostridia	E	HAD-superfamily hydrolase, subfamily IB, PSPase-like	-	-	3.1.3.87	ko:K08966	ko00270,ko01100,map00270,map01100	M00034	R07394	RC02074	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD,Put_Phosphatase
SX2_k127_1889627_0	1303518.CCALI_01963	3.28e-126	417.0	COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria	2|Bacteria	JM	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon	mpg	-	1.6.5.5,2.7.7.13,5.4.2.10,5.4.2.2,5.4.2.8	ko:K00344,ko:K00966,ko:K01840,ko:K03431,ko:K15778,ko:K16881	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00361,M00362	R00885,R00959,R01057,R01818,R02060,R08639	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3178	Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III
SX2_k127_1918171_1	477974.Daud_1651	2.943e-44	163.0	COG3259@1|root,COG3259@2|Bacteria,1UZNV@1239|Firmicutes,24F0H@186801|Clostridia,2644W@186807|Peptococcaceae	186801|Clostridia	C	Nickel-dependent hydrogenase	-	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
SX2_k127_1918171_2	1449126.JQKL01000002_gene1553	1.023e-26	116.0	COG0680@1|root,COG0680@2|Bacteria	2|Bacteria	C	spore germination	hybD	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
SX2_k127_1918171_0	411464.DESPIG_03087	5.495e-70	243.0	COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,42MMJ@68525|delta/epsilon subdivisions,2WK7X@28221|Deltaproteobacteria,2M883@213115|Desulfovibrionales	28221|Deltaproteobacteria	KO	Hydrogenase accessory protein HypB	hypB	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
SX2_k127_1918171_3	335543.Sfum_4011	8.817e-22	98.0	COG0375@1|root,COG0375@2|Bacteria,1PTY9@1224|Proteobacteria,43EVX@68525|delta/epsilon subdivisions,2X23R@28221|Deltaproteobacteria,2MQPJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
SX2_k127_1918171_4	1191523.MROS_0962	1.084e-07	63.0	COG2911@1|root,COG3867@1|root,COG2911@2|Bacteria,COG3867@2|Bacteria	2|Bacteria	G	arabinogalactan endo-1,4-beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_4,F5_F8_type_C,FlgD_ig,Glyco_hydro_53,He_PIG,Peptidase_S74,RicinB_lectin_2,SLH,fn3
SX2_k127_1920269_0	1379698.RBG1_1C00001G0609	6.94e-119	391.0	COG1702@1|root,COG1702@2|Bacteria,2NNZF@2323|unclassified Bacteria	2|Bacteria	T	PhoH-like protein	phoH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
SX2_k127_1920269_1	1208918.CDEE_0138	1.564e-11	65.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2VHKQ@28216|Betaproteobacteria,1KPR9@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
SX2_k127_1926490_1	234267.Acid_0111	7.951e-166	529.0	COG0649@1|root,COG0649@2|Bacteria,3Y3N1@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa,NiFeSe_Hases
SX2_k127_1926490_3	1379698.RBG1_1C00001G1054	5.759e-48	179.0	COG1905@1|root,COG1905@2|Bacteria,2NPSB@2323|unclassified Bacteria	2|Bacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	nuoE	-	1.6.5.3	ko:K00334,ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
SX2_k127_1926490_0	1379698.RBG1_1C00001G1055	3.169e-178	567.0	COG1894@1|root,COG1894@2|Bacteria,2NNM1@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
SX2_k127_1926490_2	1379698.RBG1_1C00001G1056	2.934e-74	255.0	COG3383@1|root,COG3383@2|Bacteria,2NNQ6@2323|unclassified Bacteria	2|Bacteria	C	Molydopterin dinucleotide binding domain	hcnA	-	1.17.1.9,1.4.99.5,1.5.3.1	ko:K00123,ko:K00302,ko:K10814	ko00260,ko00460,ko00630,ko00680,ko01100,ko01110,ko01120,ko01200,map00260,map00460,map00630,map00680,map01100,map01110,map01120,map01200	-	R00374,R00519,R00610,R05704	RC00060,RC00557,RC02796,RC02808	ko00000,ko00001,ko01000,ko02042	-	-	-	Fer2_4
SX2_k127_1926490_4	1379698.RBG1_1C00001G1056	3.238e-32	128.0	COG3383@1|root,COG3383@2|Bacteria,2NNQ6@2323|unclassified Bacteria	2|Bacteria	C	Molydopterin dinucleotide binding domain	hcnA	-	1.17.1.9,1.4.99.5,1.5.3.1	ko:K00123,ko:K00302,ko:K10814	ko00260,ko00460,ko00630,ko00680,ko01100,ko01110,ko01120,ko01200,map00260,map00460,map00630,map00680,map01100,map01110,map01120,map01200	-	R00374,R00519,R00610,R05704	RC00060,RC00557,RC02796,RC02808	ko00000,ko00001,ko01000,ko02042	-	-	-	Fer2_4
SX2_k127_1930016_0	713587.THITH_12510	3.744e-08	66.0	COG0421@1|root,COG0421@2|Bacteria,1MVV5@1224|Proteobacteria	1224|Proteobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
SX2_k127_1941496_2	886379.AEWI01000024_gene338	1.294e-12	74.0	COG4105@1|root,COG4105@2|Bacteria,4NJ5A@976|Bacteroidetes,2FNAY@200643|Bacteroidia,3XJCH@558415|Marinilabiliaceae	976|Bacteroidetes	S	Outer membrane lipoprotein	yfiO	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
SX2_k127_1941496_1	309801.trd_0651	1.607e-47	177.0	COG1057@1|root,COG1057@2|Bacteria,2G6MY@200795|Chloroflexi,27Y96@189775|Thermomicrobia	189775|Thermomicrobia	F	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
SX2_k127_1941496_0	1379698.RBG1_1C00001G0871	1.308e-84	291.0	COG0749@1|root,COG0749@2|Bacteria,2NNKA@2323|unclassified Bacteria	2|Bacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
SX2_k127_1945480_0	880073.Calab_2813	2.734e-91	305.0	COG1480@1|root,COG1480@2|Bacteria,2NP1K@2323|unclassified Bacteria	2|Bacteria	S	7TM receptor with intracellular HD hydrolase	yqfF	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
SX2_k127_1945480_1	1379698.RBG1_1C00001G0610	5.029e-26	113.0	COG0319@1|root,COG0319@2|Bacteria,2NQ0W@2323|unclassified Bacteria	2|Bacteria	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141	2.6.99.2,3.5.4.5	ko:K01489,ko:K03474,ko:K03595,ko:K07042	ko00240,ko00750,ko00983,ko01100,map00240,map00750,map00983,map01100	M00124	R01878,R02485,R05838,R08221	RC00074,RC00514,RC01476	ko00000,ko00001,ko00002,ko01000,ko03009,ko03029	-	-	-	UPF0054
SX2_k127_1965026_0	929556.Solca_2759	0.0	1035.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,1IQ80@117747|Sphingobacteriia	976|Bacteroidetes	G	PFAM Glycosyl hydrolase family 3 C terminal domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
SX2_k127_1980417_1	1379698.RBG1_1C00001G1254	9.36e-14	75.0	COG4796@1|root,COG4796@2|Bacteria,2NPEQ@2323|unclassified Bacteria	2|Bacteria	U	Secretin and TonB N terminus short domain	-	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
SX2_k127_1983738_1	1519464.HY22_00480	2.115e-20	101.0	COG0859@1|root,COG0859@2|Bacteria	2|Bacteria	M	ADP-heptose-lipopolysaccharide heptosyltransferase activity	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
SX2_k127_1983738_0	1379698.RBG1_1C00001G1033	9.7e-128	421.0	COG1132@1|root,COG1132@2|Bacteria,2NNVD@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	msbA	-	-	ko:K02021,ko:K06147,ko:K06148,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21	-	-	ABC_membrane,ABC_tran
SX2_k127_1992838_0	1041159.AZUW01000007_gene4984	2.462e-32	136.0	COG3740@1|root,COG3740@2|Bacteria,1NHKT@1224|Proteobacteria,2U82W@28211|Alphaproteobacteria,4BDKN@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Caudovirus prohead serine protease	-	-	-	ko:K06904	-	-	-	-	ko00000	-	-	-	Peptidase_S78
SX2_k127_2000307_0	313612.L8106_12235	4.246e-77	283.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G1QI@1117|Cyanobacteria,1H7BP@1150|Oscillatoriales	1117|Cyanobacteria	NU	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_10,TPR_12,TPR_7,TPR_8
SX2_k127_2010225_1	1027292.HMPREF9372_0847	2.613e-33	136.0	COG0741@1|root,COG0741@2|Bacteria,1V6DD@1239|Firmicutes,4HIWA@91061|Bacilli,26FJU@186818|Planococcaceae	91061|Bacilli	M	Transglycosylase SLT domain	yjbJ	-	-	-	-	-	-	-	-	-	-	-	SLT
SX2_k127_2010225_2	1291050.JAGE01000001_gene1740	2.552e-11	70.0	COG3418@1|root,COG3418@2|Bacteria,1VF67@1239|Firmicutes,24SF3@186801|Clostridia	186801|Clostridia	NOU	PFAM FlgN	-	-	-	-	-	-	-	-	-	-	-	-	FlgN
SX2_k127_2010225_0	1157490.EL26_06275	8.255e-55	203.0	COG1256@1|root,COG1256@2|Bacteria,1TPXH@1239|Firmicutes,4HAKM@91061|Bacilli,27902@186823|Alicyclobacillaceae	91061|Bacilli	N	Flagellar basal body rod FlgEFG protein C-terminal	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
SX2_k127_2018891_0	1121423.JONT01000010_gene1784	3.87e-81	274.0	COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia,260YV@186807|Peptococcaceae	186801|Clostridia	C	PFAM isocitrate isopropylmalate dehydrogenase	icd	-	1.1.1.41,1.1.1.83,1.1.1.93,4.1.1.73	ko:K00030,ko:K07246	ko00020,ko00630,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00650,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00215,R00709,R01751,R02545,R06180	RC00084,RC00105,RC00114,RC00594	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
SX2_k127_2018891_2	1004149.AFOE01000006_gene2024	2.015e-31	136.0	COG4990@1|root,COG4990@2|Bacteria,4NFZX@976|Bacteroidetes,1HXZ6@117743|Flavobacteriia	976|Bacteroidetes	S	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	BtrH_N,DUF4872
SX2_k127_2018891_4	157783.LK03_16750	9.335e-12	77.0	COG2244@1|root,COG2244@2|Bacteria,1NCIA@1224|Proteobacteria,1S599@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
SX2_k127_2018891_1	1379698.RBG1_1C00001G0342	3.145e-55	205.0	COG2908@1|root,COG2908@2|Bacteria,2NPKW@2323|unclassified Bacteria	2|Bacteria	S	Calcineurin-like phosphoesterase	lpxH	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0019897,GO:0019898,GO:0030145,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	3.6.1.54	ko:K03269	ko00540,ko01100,map00540,map01100	M00060	R04549	RC00002	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iE2348C_1286.E2348C_0457	Metallophos,Metallophos_2
SX2_k127_2018891_3	1379698.RBG1_1C00001G0179	7.347e-31	138.0	COG0065@1|root,COG0065@2|Bacteria	2|Bacteria	E	3-isopropylmalate dehydratase activity	-	-	4.2.1.33,4.2.1.35,4.2.1.36	ko:K01703,ko:K01705	ko00290,ko00300,ko00660,ko00966,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00300,map00660,map00966,map01100,map01110,map01120,map01130,map01210,map01230	M00030,M00432,M00433,M00535	R03896,R03898,R03968,R04001,R04371,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00618,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
SX2_k127_2032077_0	1220582.RRU01S_07_03090	0.0001634	53.0	COG3307@1|root,COG3307@2|Bacteria,1N0EK@1224|Proteobacteria,2UI1H@28211|Alphaproteobacteria,4BMWM@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Lipid A core - O-antigen ligase and related enzymes	exoQ	-	-	ko:K16567	-	-	-	-	ko00000	-	-	-	Wzy_C
SX2_k127_2032077_1	1336237.JAEE01000007_gene163	0.0002561	51.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,1RNB0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	protein involved in exopolysaccharide biosynthesis	wzc	GO:0003674,GO:0003824,GO:0004672,GO:0004713,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018108,GO:0018193,GO:0018212,GO:0019538,GO:0031224,GO:0036211,GO:0038083,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044464,GO:0046777,GO:0071704,GO:0071944,GO:0140096,GO:1901564	-	ko:K16692	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_31,GNVR,Wzz
SX2_k127_2059947_4	290397.Adeh_0995	4.171e-13	72.0	COG1832@1|root,COG1832@2|Bacteria,1NJW8@1224|Proteobacteria,42WY1@68525|delta/epsilon subdivisions,2WT3S@28221|Deltaproteobacteria,2Z10K@29|Myxococcales	28221|Deltaproteobacteria	S	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2
SX2_k127_2059947_2	1408813.AYMG01000028_gene2442	4.067e-37	147.0	COG1943@1|root,COG1943@2|Bacteria,4NTCS@976|Bacteroidetes,1ITNU@117747|Sphingobacteriia	976|Bacteroidetes	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
SX2_k127_2059947_5	331678.Cphamn1_1380	1.627e-11	75.0	COG0457@1|root,COG0457@2|Bacteria	331678.Cphamn1_1380|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2059947_0	1304284.L21TH_2281	1.765e-109	364.0	COG3426@1|root,COG3426@2|Bacteria,1TPKE@1239|Firmicutes,24993@186801|Clostridia,36EGP@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the acetokinase family	buk	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0044237,GO:0044424,GO:0044464,GO:0047761	2.7.2.7	ko:K00929	ko00650,ko01100,map00650,map01100	-	R01688	RC00002,RC00043	ko00000,ko00001,ko01000	-	-	-	Acetate_kinase
SX2_k127_2059947_1	2325.TKV_c19230	2.519e-49	182.0	COG1014@1|root,COG1014@2|Bacteria,1V1DT@1239|Firmicutes,24HIC@186801|Clostridia,42GK5@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Pyruvate ketoisovalerate oxidoreductase	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
SX2_k127_2059947_3	316067.Geob_2794	1.125e-34	137.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42N44@68525|delta/epsilon subdivisions,2WIX6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA-1	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
SX2_k127_2063801_0	706587.Desti_0562	2.146e-27	123.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2MQU0@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	PDZ domain (Also known as DHR or GLGF)	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
SX2_k127_2063801_1	1121904.ARBP01000011_gene1396	7.317e-23	112.0	COG1404@1|root,COG1572@1|root,COG3291@1|root,COG1404@2|Bacteria,COG1572@2|Bacteria,COG3291@2|Bacteria,4NF1M@976|Bacteroidetes,47NC9@768503|Cytophagia	976|Bacteroidetes	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
SX2_k127_2102213_0	861299.J421_3007	2.957e-24	103.0	2EQ8R@1|root,33HV0@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2102213_1	87626.PTD2_14139	0.0002437	51.0	28JTM@1|root,2Z9IU@2|Bacteria,1R4C3@1224|Proteobacteria,1S120@1236|Gammaproteobacteria,2Q2AT@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
SX2_k127_2117154_0	237368.SCABRO_01369	6.639e-65	240.0	COG2304@1|root,COG2304@2|Bacteria,2J1UV@203682|Planctomycetes	203682|Planctomycetes	S	von Willebrand factor type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA
SX2_k127_2117154_2	368407.Memar_1932	6.524e-57	206.0	COG1515@1|root,arCOG00929@2157|Archaea,2XURE@28890|Euryarchaeota,2N9UV@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA	nfi	-	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
SX2_k127_2117154_1	1131269.AQVV01000001_gene1427	5.17e-63	229.0	COG1562@1|root,COG1562@2|Bacteria	2|Bacteria	I	ergosterol biosynthetic process	crtB	-	2.5.1.21,2.5.1.32,2.5.1.99	ko:K00801,ko:K02291,ko:K18163	ko00100,ko00906,ko00909,ko01062,ko01100,ko01110,ko01130,ko04714,map00100,map00906,map00909,map01062,map01100,map01110,map01130,map04714	M00097	R00702,R02065,R02872,R04218,R06223,R07270,R10177	RC00362,RC00796,RC01101,RC02839,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	SQS_PSY
SX2_k127_2117154_4	1037409.BJ6T_25890	1.367e-12	74.0	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2UCYK@28211|Alphaproteobacteria,3JZIF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
SX2_k127_2117154_3	756499.Desde_3965	1.707e-39	151.0	COG1055@1|root,COG1055@2|Bacteria,1TT1V@1239|Firmicutes,24ART@186801|Clostridia	186801|Clostridia	P	Na H antiporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS_2
SX2_k127_2139388_2	756067.MicvaDRAFT_0859	2.472e-50	187.0	COG0596@1|root,COG0596@2|Bacteria,1GQ5T@1117|Cyanobacteria,1H97N@1150|Oscillatoriales	1117|Cyanobacteria	S	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC)	menH	-	4.2.99.20	ko:K08680	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08166	RC02148,RC02475	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
SX2_k127_2139388_0	459495.SPLC1_S530050	1.731e-141	474.0	COG1165@1|root,COG1165@2|Bacteria,1G1FW@1117|Cyanobacteria,1H8TT@1150|Oscillatoriales	1117|Cyanobacteria	H	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)	menD	-	2.2.1.9	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08165	RC02186	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M_2,TPP_enzyme_N
SX2_k127_2139388_1	266117.Rxyl_2897	1.293e-58	211.0	COG1169@1|root,COG1169@2|Bacteria,2GKE8@201174|Actinobacteria,4CQEB@84995|Rubrobacteria	84995|Rubrobacteria	HQ	chorismate binding enzyme	menF	-	5.4.4.2	ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	M00116	R01717	RC00588	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_bind
SX2_k127_2151720_1	1379698.RBG1_1C00001G0988	2.798e-26	123.0	COG1413@1|root,COG1413@2|Bacteria,2NQWQ@2323|unclassified Bacteria	2|Bacteria	C	lyase activity	-	-	3.4.24.3	ko:K01387,ko:K03301	-	-	-	-	ko00000,ko01000,ko01002,ko02042	2.A.12	-	-	DUF1822,DUF4132,HEAT_2,HEAT_PBS,Peptidase_M9,Peptidase_M9_N,Sulfatase
SX2_k127_2151720_0	1304888.ATWF01000001_gene883	7.382e-58	213.0	COG1409@1|root,COG1409@2|Bacteria,2GG4Q@200930|Deferribacteres	200930|Deferribacteres	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
SX2_k127_2151720_2	491952.Mar181_1164	6.413e-26	110.0	COG2350@1|root,COG2350@2|Bacteria	2|Bacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
SX2_k127_216059_6	411463.EUBVEN_02463	6.045e-15	76.0	COG0233@1|root,COG0233@2|Bacteria,1V1F2@1239|Firmicutes,24HWS@186801|Clostridia,25WFH@186806|Eubacteriaceae	186801|Clostridia	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
SX2_k127_216059_1	768706.Desor_4646	5.232e-87	294.0	COG0528@1|root,COG0528@2|Bacteria,1TPXN@1239|Firmicutes,247KR@186801|Clostridia,260FG@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
SX2_k127_216059_2	324057.Pjdr2_3420	1.916e-77	264.0	COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,4HBDV@91061|Bacilli,26QD1@186822|Paenibacillaceae	91061|Bacilli	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	GO:0001871,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005623,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0019538,GO:0030246,GO:0030247,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
SX2_k127_216059_0	1379698.RBG1_1C00001G1017	3.341e-102	338.0	COG0052@1|root,COG0052@2|Bacteria,2NP4M@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
SX2_k127_216059_4	1279038.KB907339_gene1232	9.566e-36	139.0	COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,2U5B5@28211|Alphaproteobacteria,2JRR2@204441|Rhodospirillales	204441|Rhodospirillales	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
SX2_k127_216059_3	1231241.Mc24_04405	3.582e-43	161.0	COG0102@1|root,COG0102@2|Bacteria,2GD15@200918|Thermotogae	200918|Thermotogae	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
SX2_k127_216059_5	1379698.RBG1_1C00001G1453	5.805e-32	126.0	COG0112@1|root,COG0112@2|Bacteria,2NP28@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	GO:0001505,GO:0003674,GO:0003824,GO:0004372,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006546,GO:0006563,GO:0006565,GO:0006730,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009070,GO:0009071,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0016742,GO:0017144,GO:0019264,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042133,GO:0042135,GO:0042136,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	iG2583_1286.G2583_3081,iIT341.HP0183	SHMT
SX2_k127_216817_2	1341157.RF007C_10815	0.000399	53.0	COG4124@1|root,COG4124@2|Bacteria,1UFDU@1239|Firmicutes,250ZA@186801|Clostridia,3WPV2@541000|Ruminococcaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 26 family	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_216817_1	1232410.KI421413_gene769	2.742e-51	189.0	COG0664@1|root,COG0664@2|Bacteria,1MZZD@1224|Proteobacteria,42QUX@68525|delta/epsilon subdivisions,2WMWV@28221|Deltaproteobacteria,43SH0@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	helix_turn_helix, cAMP Regulatory protein	fnr-1	-	-	ko:K01420,ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
SX2_k127_216817_0	742766.HMPREF9455_01566	6.25e-70	243.0	COG2461@1|root,COG2461@2|Bacteria,4NJQA@976|Bacteroidetes,2FTB0@200643|Bacteroidia,22X5V@171551|Porphyromonadaceae	976|Bacteroidetes	S	Hemerythrin HHE cation binding domain protein	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF1858,DUF438,Hemerythrin,PAS_10
SX2_k127_217393_1	1123371.ATXH01000015_gene1664	7.056e-54	198.0	COG1269@1|root,COG1269@2|Bacteria,2GICC@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Transmembrane exosortase (Exosortase_EpsH)	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
SX2_k127_217393_2	1411685.U062_01020	4.943e-24	110.0	COG1269@1|root,COG1269@2|Bacteria,1MXZG@1224|Proteobacteria,1RQYZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	eight transmembrane protein EpsH	-	-	-	-	-	-	-	-	-	-	-	-	DUF3485,Exosortase_EpsH
SX2_k127_217393_0	1379698.RBG1_1C00001G1327	7.155e-87	302.0	COG0382@1|root,COG0382@2|Bacteria,2NNVJ@2323|unclassified Bacteria	2|Bacteria	H	UbiA prenyltransferase family	ubiA	-	-	-	-	-	-	-	-	-	-	-	UbiA
SX2_k127_217393_3	1408473.JHXO01000001_gene2145	1.4e-14	84.0	2CK1R@1|root,32V4M@2|Bacteria,4NTYZ@976|Bacteroidetes,2FU5M@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2178722_0	1144275.COCOR_02677	3.757e-50	187.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,42P35@68525|delta/epsilon subdivisions,2WJFA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
SX2_k127_2197448_1	1379698.RBG1_1C00001G1080	2.715e-23	109.0	COG2091@1|root,COG2091@2|Bacteria,2NQPA@2323|unclassified Bacteria	2|Bacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
SX2_k127_2197448_0	761193.Runsl_1910	1.767e-176	567.0	COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,4PM8I@976|Bacteroidetes,47N7Y@768503|Cytophagia	976|Bacteroidetes	QU	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,PD40
SX2_k127_2201108_2	926560.KE387023_gene1235	4.688e-06	59.0	COG3895@1|root,COG4249@1|root,COG3895@2|Bacteria,COG4249@2|Bacteria,1WIA5@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM PEGA domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4384,PEGA
SX2_k127_2201108_1	1045858.Bint_2843	3.113e-09	69.0	COG0457@1|root,COG0457@2|Bacteria	1045858.Bint_2843|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2218632_1	518766.Rmar_1964	7.143e-20	92.0	2CD20@1|root,2Z7SQ@2|Bacteria,4NEQ1@976|Bacteroidetes,1FJ5E@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2218632_2	298654.FraEuI1c_3938	1.637e-05	55.0	COG3871@1|root,COG3871@2|Bacteria,2I3KD@201174|Actinobacteria,4EU7Z@85013|Frankiales	201174|Actinobacteria	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
SX2_k127_2218632_0	1047013.AQSP01000130_gene1883	6.958e-74	253.0	COG2256@1|root,COG2256@2|Bacteria,2NNTG@2323|unclassified Bacteria	2|Bacteria	L	MgsA AAA+ ATPase C terminal	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
SX2_k127_2239883_0	525904.Tter_1698	4.203e-228	713.0	COG0719@1|root,COG0719@2|Bacteria,2NNKT@2323|unclassified Bacteria	2|Bacteria	O	FeS assembly protein SufB	sufB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360	-	ko:K07033,ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
SX2_k127_2239883_2	751945.Theos_0111	2.811e-50	196.0	COG0719@1|root,COG0719@2|Bacteria,1WJ1E@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	TIGRFAM FeS assembly protein SufD	-	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
SX2_k127_2239883_1	525904.Tter_1696	7.985e-131	430.0	COG0520@1|root,COG0520@2|Bacteria,2NNS0@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
SX2_k127_2239883_4	1120972.AUMH01000015_gene1287	3.885e-39	149.0	COG0822@1|root,COG0822@2|Bacteria,1V3H9@1239|Firmicutes,4HIJ0@91061|Bacilli,279WU@186823|Alicyclobacillaceae	91061|Bacilli	C	NifU-like N terminal domain	nifU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
SX2_k127_2239883_5	215803.DB30_8194	2.896e-17	93.0	COG1361@1|root,COG1572@1|root,COG1361@2|Bacteria,COG1572@2|Bacteria,1QX43@1224|Proteobacteria	2|Bacteria	M	Conserved repeat domain	-	-	3.4.21.10	ko:K01317	-	-	-	-	ko00000,ko01000,ko01002,ko04131	-	-	-	CARDB,DUF11,DUF5011,Peptidase_M11
SX2_k127_2239883_3	1229487.AMYW01000076_gene2610	2.989e-41	169.0	COG3391@1|root,COG3391@2|Bacteria,4PMIF@976|Bacteroidetes,1IKM0@117743|Flavobacteriia,2P0WA@237|Flavobacterium	976|Bacteroidetes	N	HYR domain	-	-	-	-	-	-	-	-	-	-	-	-	HYR,Laminin_G_3
SX2_k127_2246004_2	309807.SRU_2321	1.273e-10	68.0	2DMY6@1|root,32UCD@2|Bacteria,4NVHX@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2246004_1	945713.IALB_0421	1.416e-157	503.0	COG1294@1|root,COG1294@2|Bacteria	2|Bacteria	C	oxidative phosphorylation	cydB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	iECABU_c1320.ECABU_c10120,iLF82_1304.LF82_0101,iNRG857_1313.NRG857_04455,iPC815.YPO1118,ic_1306.c1120	Cyt_bd_oxida_II
SX2_k127_2246004_0	945713.IALB_0420	5.412e-180	572.0	COG1271@1|root,COG1271@2|Bacteria	2|Bacteria	C	aerobic electron transport chain	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
SX2_k127_2259858_6	335543.Sfum_0443	0.0002005	53.0	COG3218@1|root,COG3218@2|Bacteria,1QWQA@1224|Proteobacteria,42VJ7@68525|delta/epsilon subdivisions,2WS0Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Ethylbenzene dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	EB_dh
SX2_k127_2259858_2	1379698.RBG1_1C00001G0331	1.562e-55	210.0	COG2067@1|root,COG2067@2|Bacteria,2NPV7@2323|unclassified Bacteria	2|Bacteria	I	long-chain fatty acid transport protein	porQ	-	-	-	-	-	-	-	-	-	-	-	PorP_SprF
SX2_k127_2259858_4	309807.SRU_2651	4.364e-07	58.0	29GCI@1|root,30SMI@2|Bacteria,4PENN@976|Bacteroidetes,1FJCI@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Lipopolysaccharide-assembly	-	-	-	-	-	-	-	-	-	-	-	-	LptE
SX2_k127_2259858_1	1121422.AUMW01000005_gene654	7.929e-123	406.0	COG1228@1|root,COG1228@2|Bacteria,1TP2J@1239|Firmicutes,24AGR@186801|Clostridia,260J1@186807|Peptococcaceae	186801|Clostridia	Q	PFAM Amidohydrolase family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
SX2_k127_2259858_0	370438.PTH_0107	9.573e-145	470.0	COG0477@1|root,COG2814@2|Bacteria,1TRUT@1239|Firmicutes,25E84@186801|Clostridia,260VE@186807|Peptococcaceae	186801|Clostridia	EGP	PFAM Bacterial protein of	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
SX2_k127_2259858_3	1127673.GLIP_0877	3.712e-16	83.0	COG1668@1|root,COG1668@2|Bacteria,1R3RG@1224|Proteobacteria,1T04X@1236|Gammaproteobacteria,46D06@72275|Alteromonadaceae	1236|Gammaproteobacteria	CP	ABC-2 family transporter protein	-	-	-	ko:K09696	ko02010,ko02020,map02010,map02020	M00253	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.115	-	-	ABC2_membrane_2,ABC2_membrane_3
SX2_k127_230883_1	502025.Hoch_4289	3.535e-15	83.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SX2_k127_230883_0	1379698.RBG1_1C00001G1104	4.027e-29	128.0	2B0A3@1|root,31SM2@2|Bacteria,2NRWJ@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function (DUF1573)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1573
SX2_k127_2316950_2	679926.Mpet_2494	1.221e-69	254.0	COG0535@1|root,arCOG00938@2157|Archaea,2Y8D0@28890|Euryarchaeota,2NAAK@224756|Methanomicrobia	224756|Methanomicrobia	S	radical SAM domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
SX2_k127_2316950_0	273068.TTE2746	3.831e-81	287.0	COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,24A6D@186801|Clostridia,42J4J@68295|Thermoanaerobacterales	186801|Clostridia	C	Best Blastp hit gi 7462068 pir H72266 astB chuR-related protein - Thermotoga maritima (strain MSB8) gi 4981883 gb AAD36396.1 AE001787_1 (AE001787) astB chuR-related protein Thermotoga maritima , score	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM
SX2_k127_2316950_1	177439.DP2271	9.858e-71	243.0	COG2131@1|root,COG2131@2|Bacteria,1RD1P@1224|Proteobacteria,42UR6@68525|delta/epsilon subdivisions,2WR1E@28221|Deltaproteobacteria,2MPYJ@213118|Desulfobacterales	28221|Deltaproteobacteria	F	PFAM Cytidine and deoxycytidylate deaminase zinc-binding region	-	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
SX2_k127_2329119_2	1232410.KI421426_gene1402	1.281e-48	181.0	COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,42TAG@68525|delta/epsilon subdivisions,2WPRH@28221|Deltaproteobacteria,43SJK@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
SX2_k127_2329119_1	1249997.JHZW01000002_gene479	1.368e-113	375.0	COG1600@1|root,COG1600@2|Bacteria,4NFCJ@976|Bacteroidetes,1HWPH@117743|Flavobacteriia,2PG38@252356|Maribacter	976|Bacteroidetes	C	Domain of unknown function (DUF1730)	queG	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
SX2_k127_2329119_0	1121468.AUBR01000046_gene1917	5.039e-143	467.0	COG0174@1|root,COG0174@2|Bacteria,1TNZA@1239|Firmicutes,2489S@186801|Clostridia,42FXP@68295|Thermoanaerobacterales	186801|Clostridia	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
SX2_k127_2331737_0	935863.AWZR01000003_gene2845	2.795e-72	258.0	COG0438@1|root,COG0438@2|Bacteria,1MVIM@1224|Proteobacteria,1RPB8@1236|Gammaproteobacteria,1X7Y9@135614|Xanthomonadales	135614|Xanthomonadales	M	Glycosyl transferases group 1	-	-	-	ko:K21001	ko02025,map02025	-	-	-	ko00000,ko00001,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4
SX2_k127_2331737_1	479432.Sros_0655	8.45e-45	166.0	COG1004@1|root,COG1004@2|Bacteria,2GJQB@201174|Actinobacteria,4EN0U@85012|Streptosporangiales	201174|Actinobacteria	M	UDP binding domain	algD	-	1.1.1.132	ko:K00066	ko00051,ko00520,ko02020,map00051,map00520,map02020	-	R00880	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
SX2_k127_2341377_0	880073.Calab_2050	3.368e-88	296.0	COG0541@1|root,COG0541@2|Bacteria,2NNT9@2323|unclassified Bacteria	2|Bacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0030312,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0040007,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0071944,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1990904	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
SX2_k127_2341377_1	1379698.RBG1_1C00001G0947	7.137e-28	117.0	COG0228@1|root,COG0228@2|Bacteria,2NPWN@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
SX2_k127_2341377_2	1379698.RBG1_1C00001G0948	4.34e-26	109.0	COG1837@1|root,COG1837@2|Bacteria,2NPUP@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the UPF0109 family	ylqC	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
SX2_k127_2341377_3	525904.Tter_1632	3.068e-21	99.0	COG0806@1|root,COG0806@2|Bacteria,2NPUX@2323|unclassified Bacteria	2|Bacteria	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
SX2_k127_2357108_2	886293.Sinac_4401	3.145e-09	63.0	COG3871@1|root,COG3871@2|Bacteria,2J33T@203682|Planctomycetes	203682|Planctomycetes	S	Pyridoxamine 5'-phosphate oxidase like	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
SX2_k127_2357108_0	1278073.MYSTI_02808	1.17e-101	342.0	COG3342@1|root,COG3342@2|Bacteria,1MWQT@1224|Proteobacteria	1224|Proteobacteria	S	major pilin protein fima	MA20_16755	-	-	-	-	-	-	-	-	-	-	-	DUF1028
SX2_k127_2369386_0	1379698.RBG1_1C00001G0445	5.08e-193	604.0	COG0542@1|root,COG0542@2|Bacteria,2NNKN@2323|unclassified Bacteria	2|Bacteria	O	C-terminal, D2-small domain, of ClpB protein	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
SX2_k127_2369386_1	1379698.RBG1_1C00001G0446	6.01e-122	400.0	COG3869@1|root,COG3869@2|Bacteria,2NR28@2323|unclassified Bacteria	2|Bacteria	E	ATP:guanido phosphotransferase, C-terminal catalytic domain	mcsB	GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170	2.7.14.1,2.7.3.2,2.7.3.3	ko:K00933,ko:K00934,ko:K19405	ko00330,ko01100,map00330,map01100	M00047	R00554,R01881,R11090	RC00002,RC00203	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ATP-gua_Ptrans
SX2_k127_2369386_4	1379698.RBG1_1C00001G0447	2.274e-42	160.0	COG3880@1|root,COG3880@2|Bacteria,2NRIE@2323|unclassified Bacteria	2|Bacteria	S	UvrB/uvrC motif	CP_0046	GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170	2.7.14.1	ko:K19405,ko:K19411	-	-	R11090	RC00002,RC00203	ko00000,ko01000	-	-	-	GSu_C4xC__C2xCH,UVR
SX2_k127_2369386_3	671143.DAMO_1655	1.67e-66	233.0	COG1136@1|root,COG1136@2|Bacteria,2NP7F@2323|unclassified Bacteria	2|Bacteria	V	Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
SX2_k127_2369386_2	1379698.RBG1_1C00001G0449	6.259e-96	322.0	COG4591@1|root,COG4591@2|Bacteria,2NP18@2323|unclassified Bacteria	2|Bacteria	M	ABC-type transport system involved in lipoprotein release permease component	lolC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008104,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0034613,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0098796,GO:0098797,GO:1990778	-	ko:K02004,ko:K09808	ko02010,map02010	M00255,M00258	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.125	-	-	FtsX,MacB_PCD
SX2_k127_2381982_1	1047013.AQSP01000142_gene195	2.736e-55	202.0	COG0787@1|root,COG0787@2|Bacteria,2NP3R@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
SX2_k127_2381982_0	357808.RoseRS_0439	4.996e-73	255.0	COG0157@1|root,COG0157@2|Bacteria,2G6GJ@200795|Chloroflexi,375H1@32061|Chloroflexia	32061|Chloroflexia	H	Belongs to the NadC ModD family	-	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
SX2_k127_2383222_0	1379698.RBG1_1C00001G0285	5.71e-80	275.0	COG2344@1|root,COG2344@2|Bacteria,2NPI1@2323|unclassified Bacteria	2|Bacteria	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
SX2_k127_2385299_0	1379698.RBG1_1C00001G0961	2.943e-248	781.0	COG0550@1|root,COG0550@2|Bacteria,2NNS8@2323|unclassified Bacteria	2|Bacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
SX2_k127_2390157_1	1248232.BANQ01000060_gene1974	2.779e-70	252.0	COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,1RNTZ@1236|Gammaproteobacteria,1XTEE@135623|Vibrionales	135623|Vibrionales	F	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	anmK	-	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	-	AnmK
SX2_k127_2390157_0	1379698.RBG1_1C00001G0322	6.671e-73	261.0	COG2385@1|root,COG2385@2|Bacteria,2NPRR@2323|unclassified Bacteria	2|Bacteria	D	Stage II sporulation protein	-	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	SpoIID
SX2_k127_2390157_2	316067.Geob_0330	1.02e-59	226.0	COG2885@1|root,COG2885@2|Bacteria,1R4WG@1224|Proteobacteria,43AIM@68525|delta/epsilon subdivisions,2X5YU@28221|Deltaproteobacteria,43SWZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OMP_b-brl,OmpA,TSP_3
SX2_k127_2390157_3	1267535.KB906767_gene5535	1.435e-44	175.0	COG1716@1|root,COG2203@1|root,COG2208@1|root,COG1716@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,3Y4DC@57723|Acidobacteria	57723|Acidobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GAF_3,SpoIIE
SX2_k127_2399875_2	1131269.AQVV01000005_gene323	0.0002794	47.0	COG4775@1|root,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	bamA	GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
SX2_k127_2399875_1	555079.Toce_0763	4.275e-26	110.0	COG0261@1|root,COG0261@2|Bacteria,1V9YH@1239|Firmicutes,24MRS@186801|Clostridia,42GTV@68295|Thermoanaerobacterales	186801|Clostridia	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
SX2_k127_2399875_0	1379698.RBG1_1C00001G1551	3.329e-293	913.0	COG0556@1|root,COG0556@2|Bacteria,2NNPM@2323|unclassified Bacteria	2|Bacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	GO:0002682,GO:0002684,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006950,GO:0008150,GO:0009314,GO:0009380,GO:0009605,GO:0009607,GO:0009628,GO:0016020,GO:0032991,GO:0035821,GO:0042802,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044424,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
SX2_k127_240717_0	700598.Niako_6669	1.952e-87	293.0	COG0156@1|root,COG0156@2|Bacteria,4NFBU@976|Bacteroidetes,1IP7S@117747|Sphingobacteriia	976|Bacteroidetes	H	Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA	kbl	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
SX2_k127_240717_1	1121335.Clst_1411	1.203e-28	128.0	COG1109@1|root,COG1109@2|Bacteria,1TP2N@1239|Firmicutes,2481Y@186801|Clostridia,3WGEY@541000|Ruminococcaceae	186801|Clostridia	G	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain	pgcA	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
SX2_k127_2408771_1	395493.BegalDRAFT_3427	4.39e-05	46.0	COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,1RMX5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form	cobB	GO:0002252,GO:0002376,GO:0003674,GO:0003824,GO:0006464,GO:0006476,GO:0006807,GO:0006935,GO:0006950,GO:0006952,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009615,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018205,GO:0019213,GO:0019538,GO:0033558,GO:0034979,GO:0034983,GO:0035601,GO:0036048,GO:0036049,GO:0036055,GO:0036211,GO:0040011,GO:0042221,GO:0042330,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0051607,GO:0051704,GO:0051707,GO:0071704,GO:0098542,GO:0098732,GO:0140096,GO:1901564	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
SX2_k127_2408771_0	945713.IALB_2281	4.673e-16	89.0	COG0457@1|root,COG4105@1|root,COG0457@2|Bacteria,COG4105@2|Bacteria	2|Bacteria	S	cell envelope organization	-	-	-	ko:K05807,ko:K06381	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	DUF1566,PrcB_C,TPR_16,TPR_19,TPR_6,TPR_8,YfiO
SX2_k127_2417946_1	338963.Pcar_2070	2.973e-40	153.0	COG1971@1|root,COG1971@2|Bacteria,1NWBY@1224|Proteobacteria,42RE2@68525|delta/epsilon subdivisions,2WNEN@28221|Deltaproteobacteria,43THX@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Probably functions as a manganese efflux pump	mntP	-	-	-	-	-	-	-	-	-	-	-	Mntp
SX2_k127_2417946_0	1379698.RBG1_1C00001G0618	4.261e-215	686.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2NNS9@2323|unclassified Bacteria	2|Bacteria	EU	peptidase S9 prolyl oligopeptidase active site	yuxL	-	3.4.19.1	ko:K01303	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S9
SX2_k127_2417946_2	398767.Glov_3074	9.38e-10	70.0	COG4191@1|root,COG4191@2|Bacteria,1QUMH@1224|Proteobacteria,42MM2@68525|delta/epsilon subdivisions,2X7N8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
SX2_k127_2417946_3	397945.Aave_0866	2.405e-07	55.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,4A9WN@80864|Comamonadaceae	28216|Betaproteobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	pilR	-	-	ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
SX2_k127_2419946_1	1379698.RBG1_1C00001G1499	4.137e-61	215.0	COG0403@1|root,COG0403@2|Bacteria,2NNP1@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006807,GO:0008150,GO:0008152,GO:0009069,GO:0009987,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019752,GO:0032991,GO:0042133,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901605,GO:1902494,GO:1990204	1.4.4.2	ko:K00281,ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
SX2_k127_2419946_2	1379698.RBG1_1C00001G1500	3.431e-46	169.0	COG0509@1|root,COG0509@2|Bacteria,2NPMR@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
SX2_k127_2419946_0	1444309.JAQG01000099_gene4971	1.058e-153	495.0	COG0439@1|root,COG0439@2|Bacteria,1TP16@1239|Firmicutes,4HARK@91061|Bacilli,26SJC@186822|Paenibacillaceae	91061|Bacilli	I	An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
SX2_k127_2420258_0	1237149.C900_01008	4.415e-19	96.0	2E2NV@1|root,32XRV@2|Bacteria,4NSDN@976|Bacteroidetes,47RPE@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
SX2_k127_2428405_0	1173029.JH980292_gene4183	1.042e-26	121.0	COG2114@1|root,COG2203@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,1G1FY@1117|Cyanobacteria,1H99S@1150|Oscillatoriales	1117|Cyanobacteria	T	PFAM Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	FHA,GAF,Guanylate_cyc,Yop-YscD_cpl
SX2_k127_2428405_1	204669.Acid345_4293	1.743e-19	98.0	COG2823@1|root,COG2823@2|Bacteria,3Y99E@57723|Acidobacteria,2JP08@204432|Acidobacteriia	204432|Acidobacteriia	S	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2428405_4	1379698.RBG1_1C00001G1092	8.677e-06	57.0	COG2866@1|root,COG4412@1|root,COG2866@2|Bacteria,COG4412@2|Bacteria,2NPI7@2323|unclassified Bacteria	2|Bacteria	E	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	3.4.17.18,3.4.17.22	ko:K05996,ko:K07752	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	F5_F8_type_C,Peptidase_M14,Peptidase_M6,Ricin_B_lectin,fn3
SX2_k127_2434357_0	316067.Geob_2794	1.025e-77	263.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42N44@68525|delta/epsilon subdivisions,2WIX6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA-1	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
SX2_k127_2434357_1	1218084.BBJK01000137_gene7282	2.621e-44	168.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,2VSIG@28216|Betaproteobacteria,1K7PD@119060|Burkholderiaceae	28216|Betaproteobacteria	G	peptidyl-prolyl cis-trans isomerase	fkpA	-	5.2.1.8	ko:K01802,ko:K03772	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
SX2_k127_2434357_3	408672.NBCG_02438	9.181e-11	73.0	COG4447@1|root,COG4447@2|Bacteria,2GMJN@201174|Actinobacteria,4DQB1@85009|Propionibacteriales	201174|Actinobacteria	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
SX2_k127_2434357_2	1123279.ATUS01000001_gene2140	5.76e-25	112.0	COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,1RMZA@1236|Gammaproteobacteria,1J4E4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	cell division	ftsE	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0019897,GO:0019898,GO:0030554,GO:0031234,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
SX2_k127_2434357_4	1268635.Loa_02656	3.246e-07	61.0	COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,1RYBV@1236|Gammaproteobacteria,1JDSA@118969|Legionellales	118969|Legionellales	D	Part of the ABC transporter FtsEX involved in cellular division	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	-
SX2_k127_2461299_0	1232410.KI421412_gene35	2.352e-22	100.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,42NR8@68525|delta/epsilon subdivisions,2WM9T@28221|Deltaproteobacteria,43UPQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Peptidase dimerisation domain	-	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
SX2_k127_2461299_1	1280663.ATVR01000002_gene335	3.877e-15	79.0	COG2103@1|root,COG2103@2|Bacteria,1TPSF@1239|Firmicutes,247KZ@186801|Clostridia,4C0QG@830|Butyrivibrio	186801|Clostridia	G	SIS domain	murQ	-	4.2.1.126	ko:K07106	ko00520,ko01100,map00520,map01100	-	R08555	RC00397,RC00746	ko00000,ko00001,ko01000	-	-	-	SIS,SIS_2
SX2_k127_2473027_0	933262.AXAM01000005_gene2533	6.995e-41	164.0	COG1639@1|root,COG1639@2|Bacteria,1R8H3@1224|Proteobacteria,42PER@68525|delta/epsilon subdivisions,2X29A@28221|Deltaproteobacteria,2MNF5@213118|Desulfobacterales	28221|Deltaproteobacteria	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
SX2_k127_2473586_0	670487.Ocepr_2106	4.633e-23	114.0	COG4676@1|root,COG4676@2|Bacteria	2|Bacteria	UW	Protein conserved in bacteria	-	-	-	ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	CarboxypepD_reg,TPR_11,TPR_12,TPR_2,TPR_7,TPR_8
SX2_k127_2473586_1	880073.Calab_0781	4.336e-21	97.0	COG1595@1|root,COG1595@2|Bacteria,2NR5T@2323|unclassified Bacteria	2|Bacteria	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	sigG	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SX2_k127_247409_0	1379698.RBG1_1C00001G0278	1.428e-126	408.0	COG0188@1|root,COG0188@2|Bacteria,2NNNR@2323|unclassified Bacteria	2|Bacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
SX2_k127_2475663_0	1379698.RBG1_1C00001G1218	4.853e-94	324.0	COG0515@1|root,COG0515@2|Bacteria,2NQWH@2323|unclassified Bacteria	2|Bacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_8
SX2_k127_2475663_3	1379698.RBG1_1C00001G1399	4.981e-10	73.0	COG4447@1|root,COG4447@2|Bacteria,2NRC1@2323|unclassified Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,PSII_BNR
SX2_k127_2475663_4	1121904.ARBP01000017_gene5075	4.191e-08	66.0	COG2730@1|root,COG3291@1|root,COG4625@1|root,COG5492@1|root,COG2730@2|Bacteria,COG3291@2|Bacteria,COG4625@2|Bacteria,COG5492@2|Bacteria,4NJ9A@976|Bacteroidetes,47M79@768503|Cytophagia	976|Bacteroidetes	N	Bacterial Ig-like domain (group 2)	-	-	-	-	-	-	-	-	-	-	-	-	BACON,Big_2,F5_F8_type_C,LRR_5,Polysacc_deac_3
SX2_k127_2475663_2	7029.ACYPI009474-PA	4.23e-22	112.0	2CMRF@1|root,2QRK8@2759|Eukaryota,38BZ6@33154|Opisthokonta,3BC6D@33208|Metazoa,3CRA6@33213|Bilateria,41W09@6656|Arthropoda,3SING@50557|Insecta,3E8KI@33342|Paraneoptera	33208|Metazoa	O	Cartilage oligomeric matrix protein	COMP	GO:0000902,GO:0001501,GO:0001503,GO:0001932,GO:0001934,GO:0001936,GO:0001938,GO:0001968,GO:0002020,GO:0002682,GO:0002684,GO:0002685,GO:0002687,GO:0002688,GO:0002690,GO:0003416,GO:0003417,GO:0003674,GO:0005102,GO:0005178,GO:0005198,GO:0005201,GO:0005488,GO:0005496,GO:0005499,GO:0005509,GO:0005515,GO:0005518,GO:0005539,GO:0005575,GO:0005576,GO:0005604,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005912,GO:0005924,GO:0005927,GO:0006928,GO:0006950,GO:0007155,GO:0007160,GO:0007275,GO:0007399,GO:0007517,GO:0007610,GO:0008150,GO:0008201,GO:0008284,GO:0008289,GO:0009653,GO:0009790,GO:0009887,GO:0009888,GO:0009893,GO:0009987,GO:0010562,GO:0010604,GO:0010941,GO:0012505,GO:0014812,GO:0016043,GO:0016203,GO:0016477,GO:0016525,GO:0016528,GO:0016529,GO:0019220,GO:0019222,GO:0019842,GO:0019899,GO:0021700,GO:0022008,GO:0022603,GO:0022607,GO:0022610,GO:0030030,GO:0030054,GO:0030055,GO:0030154,GO:0030182,GO:0030198,GO:0030334,GO:0030335,GO:0030855,GO:0031012,GO:0031175,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0031589,GO:0031594,GO:0032101,GO:0032103,GO:0032268,GO:0032270,GO:0032501,GO:0032502,GO:0032879,GO:0032989,GO:0032990,GO:0032991,GO:0033554,GO:0033555,GO:0033627,GO:0034103,GO:0034976,GO:0035265,GO:0035989,GO:0036094,GO:0040007,GO:0040011,GO:0040012,GO:0040017,GO:0042127,GO:0042325,GO:0042327,GO:0042981,GO:0043062,GO:0043066,GO:0043067,GO:0043069,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043236,GO:0043237,GO:0043394,GO:0043395,GO:0043931,GO:0043933,GO:0044085,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045202,GO:0045765,GO:0045937,GO:0046872,GO:0048265,GO:0048266,GO:0048468,GO:0048471,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048589,GO:0048646,GO:0048666,GO:0048699,GO:0048705,GO:0048731,GO:0048736,GO:0048799,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0048870,GO:0050678,GO:0050679,GO:0050730,GO:0050731,GO:0050789,GO:0050793,GO:0050794,GO:0050839,GO:0050840,GO:0050896,GO:0050920,GO:0050921,GO:0051093,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051216,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0051270,GO:0051272,GO:0051451,GO:0051674,GO:0051716,GO:0060173,GO:0060231,GO:0060255,GO:0060343,GO:0060346,GO:0060348,GO:0060349,GO:0060350,GO:0060351,GO:0060429,GO:0060538,GO:0060548,GO:0061053,GO:0061061,GO:0061383,GO:0061430,GO:0061448,GO:0062023,GO:0065003,GO:0065007,GO:0070161,GO:0070977,GO:0071603,GO:0071622,GO:0071624,GO:0071695,GO:0071840,GO:0080090,GO:0090022,GO:0090023,GO:0090136,GO:0097159,GO:0097367,GO:0098609,GO:0098868,GO:0120036,GO:0120039,GO:1901342,GO:1901343,GO:1901681,GO:1902622,GO:1902624,GO:2000026,GO:2000145,GO:2000147,GO:2000181	-	ko:K04659	ko04145,ko04151,ko04510,ko04512,ko05144,ko05165,map04145,map04151,map04510,map04512,map05144,map05165	-	-	-	ko00000,ko00001,ko00536,ko04131,ko04147,ko04516	-	-	-	COMP,EGF,EGF_CA,TSP_3,TSP_C
SX2_k127_2475663_1	391625.PPSIR1_07912	8.653e-89	319.0	COG1404@1|root,COG1404@2|Bacteria,1R5H7@1224|Proteobacteria,434MI@68525|delta/epsilon subdivisions,2WYZ0@28221|Deltaproteobacteria,2Z0YZ@29|Myxococcales	28221|Deltaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
SX2_k127_2486199_0	1379698.RBG1_1C00001G0435	2.928e-194	642.0	COG1747@1|root,COG1747@2|Bacteria,2NP33@2323|unclassified Bacteria	2|Bacteria	M	methyltransferase	greA	-	-	-	-	-	-	-	-	-	-	-	GreA_GreB,GreA_GreB_N,SprA_N
SX2_k127_248779_1	682795.AciX8_4021	2.481e-14	82.0	COG5616@1|root,COG5616@2|Bacteria,3Y9AR@57723|Acidobacteria,2JP78@204432|Acidobacteriia	204432|Acidobacteriia	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_248779_0	1499967.BAYZ01000076_gene807	9.96e-73	248.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	gutB	-	1.1.1.14,1.1.1.303,1.1.1.4	ko:K00004,ko:K00008	ko00040,ko00051,ko00650,ko01100,map00040,map00051,map00650,map01100	M00014	R00875,R01896,R02855,R02946,R10504	RC00085,RC00102,RC00205,RC00525	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N,Glu_dehyd_C
SX2_k127_2488090_3	903818.KI912268_gene2926	3.826e-09	63.0	2EP62@1|root,33GSS@2|Bacteria	2|Bacteria	S	PFAM Type IV pilus assembly PilZ	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
SX2_k127_2488090_1	518766.Rmar_2493	2.358e-50	185.0	COG0590@1|root,COG0590@2|Bacteria,4NNJ2@976|Bacteroidetes,1FK4S@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	FJ	MafB19-like deaminase	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam,dCMP_cyt_deam_1
SX2_k127_2488090_0	1236497.BAJQ01000005_gene1088	4.574e-82	278.0	COG0745@1|root,COG0745@2|Bacteria,4NF1I@976|Bacteroidetes,2FNZV@200643|Bacteroidia	976|Bacteroidetes	K	transcriptional regulatory protein	rprY	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
SX2_k127_2491907_2	1379698.RBG1_1C00001G1516	7.24e-18	94.0	COG2982@1|root,COG2982@2|Bacteria,2NRT5@2323|unclassified Bacteria	2|Bacteria	M	AsmA-like C-terminal region	-	-	-	ko:K07289,ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	AsmA,AsmA_1,AsmA_2,DUF3971,DctA-YdbH
SX2_k127_2491907_0	1123226.KB899300_gene2801	6.471e-62	218.0	COG1045@1|root,COG1045@2|Bacteria,1TR42@1239|Firmicutes,4HAKS@91061|Bacilli,26TTE@186822|Paenibacillaceae	91061|Bacilli	E	serine acetyltransferase	cysE	GO:0000096,GO:0000097,GO:0000098,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009087,GO:0009987,GO:0016053,GO:0016054,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS02865,iYO844.BSU00930	Hexapep,SATase_N
SX2_k127_2491907_3	379066.GAU_1417	1.675e-11	75.0	2DUTE@1|root,33S5W@2|Bacteria,1ZSMI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2491907_1	656519.Halsa_2132	3.469e-29	130.0	COG1560@1|root,COG1560@2|Bacteria,1TT7A@1239|Firmicutes,24HMK@186801|Clostridia,3WANH@53433|Halanaerobiales	186801|Clostridia	M	PFAM Bacterial lipid A biosynthesis acyltransferase	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
SX2_k127_2497419_1	1237149.C900_01592	2.681e-60	226.0	295M7@1|root,2ZSYM@2|Bacteria,4NNH9@976|Bacteroidetes,47UGS@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2497419_0	1379698.RBG1_1C00001G0875	1.996e-83	280.0	COG3958@1|root,COG3958@2|Bacteria,2NQFH@2323|unclassified Bacteria	2|Bacteria	G	Transketolase, pyrimidine binding domain	tktC	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
SX2_k127_2537352_0	330214.NIDE0885	4.722e-112	373.0	COG0399@1|root,COG0399@2|Bacteria,3J09X@40117|Nitrospirae	2|Bacteria	E	Belongs to the DegT DnrJ EryC1 family	spsC	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
SX2_k127_2537352_2	871963.Desdi_0837	2.351e-30	134.0	COG0472@1|root,COG0472@2|Bacteria,1TP9V@1239|Firmicutes,247M7@186801|Clostridia,260WC@186807|Peptococcaceae	186801|Clostridia	M	PFAM Glycosyl transferase family 4	-	-	2.7.8.33,2.7.8.35	ko:K02851,ko:K13007	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
SX2_k127_2537352_1	1267535.KB906767_gene2214	1.925e-36	143.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	vioA	GO:0005575,GO:0005576,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009607,GO:0009987,GO:0009991,GO:0010106,GO:0019725,GO:0030003,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042592,GO:0042594,GO:0043207,GO:0044403,GO:0044419,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071496,GO:0075136,GO:0098771	2.6.1.33	ko:K13308,ko:K20429	ko00523,ko01130,map00523,map01130	M00797	R02773	RC00006,RC00781	ko00000,ko00001,ko00002,ko01000	-	-	-	DegT_DnrJ_EryC1
SX2_k127_2539087_0	944479.JQLX01000013_gene1447	1.06e-147	477.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,42M14@68525|delta/epsilon subdivisions,2WIN7@28221|Deltaproteobacteria,2M6KR@213113|Desulfurellales	28221|Deltaproteobacteria	I	Biotin carboxylase C-terminal domain	pccA	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
SX2_k127_2558962_1	1379698.RBG1_1C00001G1759	1.859e-112	367.0	COG0330@1|root,COG0330@2|Bacteria,2NNUC@2323|unclassified Bacteria	2|Bacteria	O	prohibitin homologues	hflC	-	-	-	-	-	-	-	-	-	-	-	Band_7
SX2_k127_2558962_0	1379698.RBG1_1C00001G1760	1.016e-112	377.0	COG1030@1|root,COG1030@2|Bacteria,2NNMU@2323|unclassified Bacteria	2|Bacteria	O	NfeD-like C-terminal, partner-binding	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD
SX2_k127_2569041_1	1379698.RBG1_1C00001G0710	8.418e-75	255.0	COG1945@1|root,COG1945@2|Bacteria,2NP74@2323|unclassified Bacteria	2|Bacteria	S	Pyruvoyl-dependent arginine decarboxylase (PvlArgDC)	pdaD	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
SX2_k127_2569041_0	1379698.RBG1_1C00001G0709	5.237e-101	337.0	COG1899@1|root,COG1899@2|Bacteria,2NR8I@2323|unclassified Bacteria	2|Bacteria	O	Deoxyhypusine synthase	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008612,GO:0009058,GO:0009987,GO:0010467,GO:0016740,GO:0016765,GO:0018193,GO:0018205,GO:0019538,GO:0034038,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
SX2_k127_2571932_0	1379698.RBG1_1C00001G1458	3.926e-23	101.0	COG1960@1|root,COG1960@2|Bacteria,2NNRN@2323|unclassified Bacteria	2|Bacteria	I	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SX2_k127_2591590_0	1033802.SSPSH_001443	9.972e-61	235.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
SX2_k127_2594281_3	756272.Plabr_3384	5.106e-13	77.0	2ANS9@1|root,31DS7@2|Bacteria,2IZX5@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2594281_0	521674.Plim_3797	1.462e-70	250.0	28MYQ@1|root,2ZB5K@2|Bacteria,2IZUC@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2594281_1	344747.PM8797T_23686	1.733e-50	187.0	29ZH8@1|root,30MGZ@2|Bacteria,2J0G3@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2594281_2	459349.CLOAM1195	9.444e-17	81.0	28MEN@1|root,2ZASA@2|Bacteria,2NQD3@2323|unclassified Bacteria	2|Bacteria	S	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2595036_0	1379698.RBG1_1C00001G1745	1.736e-51	183.0	COG1100@1|root,COG1100@2|Bacteria,2NPDD@2323|unclassified Bacteria	2|Bacteria	K	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein	mglA	GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf,DUF697,MMR_HSR1
SX2_k127_2595036_1	1379698.RBG1_1C00001G1746	6.111e-38	145.0	COG2018@1|root,COG2018@2|Bacteria,2NRUR@2323|unclassified Bacteria	2|Bacteria	S	Roadblock/LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
SX2_k127_2595949_0	1379698.RBG1_1C00001G1218	2.629e-86	306.0	COG0515@1|root,COG0515@2|Bacteria,2NQWH@2323|unclassified Bacteria	2|Bacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_8
SX2_k127_2595949_1	1120965.AUBV01000014_gene1157	0.0007466	49.0	COG4206@1|root,COG4206@2|Bacteria,4NGBJ@976|Bacteroidetes,47J8T@768503|Cytophagia	976|Bacteroidetes	H	TonB-dependent Receptor Plug Domain	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
SX2_k127_2644835_1	7739.XP_002595557.1	1.026e-09	72.0	COG0457@1|root,KOG0548@2759|Eukaryota	2759|Eukaryota	J	positive regulation of catalytic activity in other organism involved in symbiotic interaction	-	-	-	ko:K14861	-	-	-	-	ko00000,ko03009	-	-	-	DUF294,TPR_10,TPR_12,TPR_7,TPR_8
SX2_k127_2644835_2	1158601.I585_01128	3.947e-05	48.0	COG0346@1|root,COG0346@2|Bacteria,1UP0F@1239|Firmicutes,4IUX2@91061|Bacilli,4B2RR@81852|Enterococcaceae	91061|Bacilli	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SX2_k127_2644835_0	880073.Calab_3775	3.401e-97	323.0	COG0621@1|root,COG0621@2|Bacteria,2NP2U@2323|unclassified Bacteria	2|Bacteria	J	Uncharacterized protein family UPF0004	yqeV	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035598,GO:0035600,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050497,GO:0071704,GO:0090304,GO:1901360	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
SX2_k127_2646852_2	1121931.AUHG01000018_gene1394	3.487e-05	47.0	COG1295@1|root,COG1295@2|Bacteria,4NH9D@976|Bacteroidetes,1I0V2@117743|Flavobacteriia	976|Bacteroidetes	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
SX2_k127_2646852_0	1047013.AQSP01000140_gene2452	3.147e-167	532.0	COG0473@1|root,COG0473@2|Bacteria,2NNUM@2323|unclassified Bacteria	2|Bacteria	CE	Isocitrate/isopropylmalate dehydrogenase	dlpA	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh,MoCF_biosynth,RraA-like
SX2_k127_2646852_1	1379698.RBG1_1C00001G0490	3.331e-05	46.0	COG2067@1|root,COG2067@2|Bacteria,2NR8A@2323|unclassified Bacteria	2|Bacteria	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2647808_5	1379698.RBG1_1C00001G1620	2.646e-20	93.0	COG2222@1|root,COG2222@2|Bacteria,2NQVV@2323|unclassified Bacteria	2|Bacteria	M	Bacterial phospho-glucose isomerase C-terminal SIS domain	pgi	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS,bact-PGI_C
SX2_k127_2647808_0	1379698.RBG1_1C00001G0115	7.617e-91	308.0	28MEN@1|root,2ZASA@2|Bacteria,2NQD3@2323|unclassified Bacteria	2|Bacteria	S	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2647808_4	1379698.RBG1_1C00001G0114	7.947e-44	167.0	29ZH8@1|root,30MGZ@2|Bacteria,2NQ83@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2647808_1	247490.KSU1_B0648	1.47e-66	236.0	28MYQ@1|root,2ZB5K@2|Bacteria,2IZUC@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2647808_3	459349.CLOAM1198	1.186e-49	193.0	2ANS9@1|root,31DS7@2|Bacteria,2NQ66@2323|unclassified Bacteria	2|Bacteria	S	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2647808_2	1379698.RBG1_1C00001G1853	2.524e-62	221.0	COG1209@1|root,COG1209@2|Bacteria,2NNTJ@2323|unclassified Bacteria	2|Bacteria	M	Nucleotidyl transferase	-	-	2.3.1.157,2.7.7.23,2.7.7.24	ko:K00973,ko:K04042	ko00520,ko00521,ko00523,ko00525,ko01100,ko01130,map00520,map00521,map00523,map00525,map01100,map01130	M00362,M00793	R00416,R02328,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
SX2_k127_2650717_1	502025.Hoch_2498	6.283e-21	96.0	COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,42MRJ@68525|delta/epsilon subdivisions,2WITA@28221|Deltaproteobacteria,2YUDC@29|Myxococcales	28221|Deltaproteobacteria	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
SX2_k127_2650717_0	1379698.RBG1_1C00001G0866	3.987e-97	324.0	COG1674@1|root,COG1674@2|Bacteria,2NNVB@2323|unclassified Bacteria	2|Bacteria	D	Ftsk_gamma	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
SX2_k127_2659062_0	945550.VISI1226_14931	7.947e-14	79.0	COG1541@1|root,COG1541@2|Bacteria,1RFV4@1224|Proteobacteria,1S519@1236|Gammaproteobacteria,1XUMD@135623|Vibrionales	135623|Vibrionales	H	COG1541 Coenzyme F390 synthetase	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding
SX2_k127_2664379_0	1379698.RBG1_1C00001G1846	8.822e-145	474.0	COG4775@1|root,COG4775@2|Bacteria,2NNNW@2323|unclassified Bacteria	2|Bacteria	M	Surface antigen	bamA	GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
SX2_k127_2669570_0	1267535.KB906767_gene5013	9.05e-136	451.0	COG0367@1|root,COG0367@2|Bacteria,3Y75N@57723|Acidobacteria	57723|Acidobacteria	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
SX2_k127_2671841_1	326427.Cagg_1468	1.982e-35	139.0	COG1253@1|root,COG1253@2|Bacteria,2G6D1@200795|Chloroflexi,3752J@32061|Chloroflexia	32061|Chloroflexia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
SX2_k127_2671841_0	880073.Calab_3099	7.666e-187	596.0	COG1305@1|root,COG1305@2|Bacteria	2|Bacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
SX2_k127_2685368_1	1191523.MROS_1976	6.733e-40	164.0	COG4232@1|root,COG4232@2|Bacteria	2|Bacteria	CO	protein-disulfide reductase activity	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin,Thioredoxin_2,Thioredoxin_7
SX2_k127_2685368_4	240302.BN982_00535	3.015e-13	81.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,4H9KP@91061|Bacilli,3NDHF@45667|Halobacillus	91061|Bacilli	T	Transcriptional regulatory protein, C terminal	phoP	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SX2_k127_2685368_0	1379698.RBG1_1C00001G1850	8.411e-71	248.0	COG0705@1|root,COG0705@2|Bacteria,2NPSK@2323|unclassified Bacteria	2|Bacteria	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
SX2_k127_2685368_3	562970.Btus_1809	1.518e-35	142.0	COG1832@1|root,COG1832@2|Bacteria,1V7C7@1239|Firmicutes,4HIZT@91061|Bacilli,278IP@186823|Alicyclobacillaceae	91061|Bacilli	S	CoA binding domain	yneT	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
SX2_k127_2685368_2	195253.Syn6312_1568	2.559e-38	145.0	COG3118@1|root,COG3118@2|Bacteria,1G6KZ@1117|Cyanobacteria,1H0EV@1129|Synechococcus	1117|Cyanobacteria	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
SX2_k127_2685368_5	457570.Nther_2188	9.083e-11	64.0	COG4805@1|root,COG4805@2|Bacteria	2|Bacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
SX2_k127_2722394_1	410358.Mlab_1274	6.158e-17	86.0	arCOG12322@1|root,arCOG12322@2157|Archaea,2Y5I1@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2722394_0	1123267.JONN01000001_gene1012	1.368e-29	128.0	COG3595@1|root,COG3595@2|Bacteria,1N8NB@1224|Proteobacteria,2TZMI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Putative auto-transporter adhesin, head GIN domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2807
SX2_k127_2723307_0	1519464.HY22_07050	9.624e-19	96.0	2DU1M@1|root,33NIU@2|Bacteria,1FFDR@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2723307_1	1379270.AUXF01000005_gene657	9.023e-07	61.0	COG1807@1|root,COG1807@2|Bacteria,1ZSWR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Protein of unknown function (DUF2723)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723
SX2_k127_2732129_0	1379698.RBG1_1C00001G0987	3.202e-156	507.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K02481,ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
SX2_k127_2732129_1	1499967.BAYZ01000074_gene2110	8.367e-97	325.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	atoC	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
SX2_k127_2733877_0	1379698.RBG1_1C00001G0242	4.35e-164	530.0	COG0445@1|root,COG0445@2|Bacteria,2NNXQ@2323|unclassified Bacteria	2|Bacteria	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
SX2_k127_2733877_4	1122139.KB907862_gene667	1.406e-16	87.0	COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,1RMRZ@1236|Gammaproteobacteria,1XJ8Z@135619|Oceanospirillales	135619|Oceanospirillales	J	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
SX2_k127_2733877_1	203119.Cthe_2377	5.161e-91	306.0	COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,2488C@186801|Clostridia,3WGTZ@541000|Ruminococcaceae	186801|Clostridia	D	CobQ CobB MinD ParA nucleotide binding domain	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
SX2_k127_2733877_2	562970.Btus_3314	3.448e-76	266.0	COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,4H9TB@91061|Bacilli,27886@186823|Alicyclobacillaceae	91061|Bacilli	K	Belongs to the ParB family	spo0J	GO:0005575,GO:0005622,GO:0005623,GO:0007059,GO:0008150,GO:0009295,GO:0009987,GO:0022603,GO:0042173,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0043937,GO:0043938,GO:0044424,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0065007	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	HTH_3,KorB,ParBc
SX2_k127_2733877_3	1289135.A966_02058	6.939e-21	101.0	COG0739@1|root,COG0739@2|Bacteria,2J5SN@203691|Spirochaetes	203691|Spirochaetes	M	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
SX2_k127_2739728_1	1379698.RBG1_1C00001G0394	5.028e-105	352.0	COG0771@1|root,COG0771@2|Bacteria,2NP27@2323|unclassified Bacteria	2|Bacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
SX2_k127_2739728_0	398767.Glov_0673	8.485e-107	354.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,42MCP@68525|delta/epsilon subdivisions,2WJDS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	iAF987.Gmet_0409	Glycos_transf_4,MraY_sig1
SX2_k127_2740245_0	1385511.N783_07635	1.891e-142	469.0	COG2304@1|root,COG2304@2|Bacteria,1TSU7@1239|Firmicutes,4HPXN@91061|Bacilli	91061|Bacilli	S	Domain of unknown function (DUF3520)	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	DUF3520,VWA,vWF_A
SX2_k127_2741107_0	323850.Shew_1646	1.03e-34	148.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,1RYRB@1236|Gammaproteobacteria,2QAIB@267890|Shewanellaceae	1236|Gammaproteobacteria	S	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SX2_k127_2741107_2	452637.Oter_1881	3.996e-22	103.0	COG1680@1|root,COG4319@1|root,COG1680@2|Bacteria,COG4319@2|Bacteria,46V0A@74201|Verrucomicrobia,3K85Q@414999|Opitutae	414999|Opitutae	V	beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SX2_k127_2741107_1	1379698.RBG1_1C00001G1218	4.082e-25	111.0	COG0515@1|root,COG0515@2|Bacteria,2NQWH@2323|unclassified Bacteria	2|Bacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_8
SX2_k127_2749014_2	1183377.Py04_0229	2.251e-43	168.0	COG1122@1|root,arCOG00202@2157|Archaea,2XT28@28890|Euryarchaeota,242QY@183968|Thermococci	183968|Thermococci	P	part of an ABC transporter complex. Responsible for energy coupling to the transport system	cbiO	-	-	ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
SX2_k127_2749014_1	1379698.RBG1_1C00001G0347	4.73e-83	282.0	COG1657@1|root,COG1657@2|Bacteria,2NP7R@2323|unclassified Bacteria	2|Bacteria	I	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159,Prenyltrans
SX2_k127_2749014_0	1379698.RBG1_1C00001G0350	5.029e-167	566.0	COG1196@1|root,COG1196@2|Bacteria,2NNSS@2323|unclassified Bacteria	2|Bacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_275976_1	1379698.RBG1_1C00001G1129	1.655e-88	301.0	COG0142@1|root,COG0142@2|Bacteria,2NP6N@2323|unclassified Bacteria	2|Bacteria	H	Belongs to the FPP GGPP synthase family	ispA	GO:0003674,GO:0003824,GO:0004161,GO:0004311,GO:0004337,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009536,GO:0009842,GO:0009987,GO:0016114,GO:0016740,GO:0016765,GO:0019637,GO:0033383,GO:0033384,GO:0033385,GO:0033386,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045337,GO:0045338,GO:0071704,GO:0090407,GO:1901576	2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90	ko:K00795,ko:K02523,ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061,R09248	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	iPC815.YPO3176,iSFV_1184.SFV_0386	polyprenyl_synt
SX2_k127_275976_0	1379698.RBG1_1C00001G1879	5.212e-224	711.0	COG1154@1|root,COG1154@2|Bacteria,2NNNA@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008614,GO:0008615,GO:0008654,GO:0008661,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0017144,GO:0018130,GO:0019288,GO:0019438,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030145,GO:0030975,GO:0030976,GO:0032787,GO:0034641,GO:0036094,GO:0040007,GO:0042180,GO:0042181,GO:0042364,GO:0042723,GO:0042724,GO:0042816,GO:0042819,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:1901135,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663,GO:1901681	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	iEcSMS35_1347.EcSMS35_0456,iJN746.PP_0527	DXP_synthase_N,Transket_pyr,Transketolase_C
SX2_k127_275976_2	1379698.RBG1_1C00001G1130	3.226e-66	235.0	COG0061@1|root,COG0061@2|Bacteria,2NP7T@2323|unclassified Bacteria	2|Bacteria	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iEcSMS35_1347.EcSMS35_2767,iHN637.CLJU_RS05480,iLJ478.TM1733,iSB619.SA_RS04895	NAD_kinase
SX2_k127_2777913_2	1378168.N510_00126	1.376e-05	51.0	COG0768@1|root,COG0768@2|Bacteria,1TP93@1239|Firmicutes	1239|Firmicutes	M	penicillin-binding protein	spoVD	-	-	ko:K08384	ko00550,map00550	-	-	-	ko00000,ko00001,ko01011	-	-	-	PASTA,PBP_dimer,Transpeptidase
SX2_k127_2777913_0	1379698.RBG1_1C00001G0391	1.57e-125	419.0	COG0769@1|root,COG0769@2|Bacteria,2NNZM@2323|unclassified Bacteria	2|Bacteria	M	acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.10,6.3.2.13	ko:K01928,ko:K15792	ko00300,ko00550,map00300,map00550	-	R02788,R04617	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
SX2_k127_2777913_1	1411123.JQNH01000001_gene320	9.354e-09	59.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,2TR0Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10,6.3.2.13	ko:K01928,ko:K01929,ko:K15792	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R02788,R04573,R04617	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
SX2_k127_2810301_0	96561.Dole_2179	9.512e-66	231.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,42M14@68525|delta/epsilon subdivisions,2WIN7@28221|Deltaproteobacteria,2MHYZ@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM Carbamoyl-phosphate synthase L chain	pccA	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
SX2_k127_2810301_1	4792.ETI38472	3.441e-08	62.0	COG4770@1|root,KOG0238@2759|Eukaryota,3QC0I@4776|Peronosporales	4776|Peronosporales	EI	Biotin-requiring enzyme	-	-	6.4.1.4	ko:K01968	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
SX2_k127_2811229_3	247490.KSU1_B0647	1.149e-47	180.0	2ANS9@1|root,31DS7@2|Bacteria,2IZX5@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2811229_1	247490.KSU1_B0648	1.053e-56	208.0	28MYQ@1|root,2ZB5K@2|Bacteria,2IZUC@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2811229_2	247490.KSU1_B0649	1.361e-50	188.0	29ZH8@1|root,30MGZ@2|Bacteria,2J0G3@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2811229_0	1379698.RBG1_1C00001G0119	5.602e-88	305.0	28MEN@1|root,2ZASA@2|Bacteria,2NQD3@2323|unclassified Bacteria	2|Bacteria	S	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2811229_4	1379698.RBG1_1C00001G0116	1.442e-47	177.0	2ANS9@1|root,31DS7@2|Bacteria,2NQ66@2323|unclassified Bacteria	2|Bacteria	S	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2827785_1	710685.MycrhN_2104	7.851e-17	91.0	2EHX5@1|root,33BNR@2|Bacteria,2GPW7@201174|Actinobacteria,23ARP@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2827785_0	1168034.FH5T_11060	2.155e-104	355.0	COG1305@1|root,COG1305@2|Bacteria	2|Bacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
SX2_k127_2830830_0	1191523.MROS_1555	5.755e-171	549.0	COG1132@1|root,COG1132@2|Bacteria	2|Bacteria	V	(ABC) transporter	MdlB	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SX2_k127_2830830_1	1379698.RBG1_1C00001G0560	2.829e-84	288.0	COG0483@1|root,COG0483@2|Bacteria,2NP94@2323|unclassified Bacteria	2|Bacteria	G	Inositol monophosphatase	suhB	GO:0003674,GO:0003824,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616	3.1.3.25,3.1.3.7	ko:K01082,ko:K01092	ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070	M00131	R00188,R00508,R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	Inositol_P
SX2_k127_2830830_3	1379698.RBG1_1C00001G0561	1.11e-37	151.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K02490	ko02020,ko02024,map02020,map02024	M00485	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HATPase_c,HisKA_2,PAS_3,PAS_9,Response_reg,SpoIIE
SX2_k127_2830830_4	744979.R2A130_0891	2.211e-27	113.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	MA20_14720	-	-	ko:K10111	ko02010,map02010	M00194,M00200,M00204,M00207,M00491	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
SX2_k127_2830830_2	311403.Arad_8052	3.863e-69	243.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,4B7FG@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
SX2_k127_2830830_5	511051.CSE_12490	1.806e-13	74.0	COG1521@1|root,COG1521@2|Bacteria	2|Bacteria	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1986	Pan_kinase
SX2_k127_2836349_1	243231.GSU1940	1.596e-29	124.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42Q6R@68525|delta/epsilon subdivisions,2WJN4@28221|Deltaproteobacteria,43TK0@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Domains REC, sigma54 interaction, HTH8	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
SX2_k127_2836349_0	1123367.C666_04380	1.233e-44	179.0	COG4191@1|root,COG4191@2|Bacteria,1MU55@1224|Proteobacteria,2VIZD@28216|Betaproteobacteria,2KV0R@206389|Rhodocyclales	206389|Rhodocyclales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
SX2_k127_2845723_1	452637.Oter_4432	2.196e-13	71.0	COG3696@1|root,COG3696@2|Bacteria,46SJ1@74201|Verrucomicrobia,3K7EV@414999|Opitutae	414999|Opitutae	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
SX2_k127_2845723_0	335543.Sfum_2436	2.215e-96	334.0	COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,42PKU@68525|delta/epsilon subdivisions,2WM5K@28221|Deltaproteobacteria,2MRTA@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07798,ko:K15727	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1,8.A.1.2.1	-	-	DUF3347,HlyD_D23
SX2_k127_2849073_0	316067.Geob_1919	7.302e-304	957.0	COG0366@1|root,COG0366@2|Bacteria,1PDXT@1224|Proteobacteria,42MZ1@68525|delta/epsilon subdivisions,2WMHA@28221|Deltaproteobacteria,43U2K@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	PFAM alpha amylase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
SX2_k127_28901_0	1379698.RBG1_1C00001G1211	1.92e-123	401.0	COG0034@1|root,COG0034@2|Bacteria,2NNSY@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009507,GO:0009536,GO:0040007,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iSB619.SA_RS05225	GATase_6,GATase_7,Pribosyltran
SX2_k127_28901_1	880072.Desac_2104	6.626e-55	199.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42P7Z@68525|delta/epsilon subdivisions,2WK06@28221|Deltaproteobacteria,2MSIS@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
SX2_k127_2896919_1	1125863.JAFN01000001_gene3418	1.924e-43	169.0	COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,42PA2@68525|delta/epsilon subdivisions,2WNJ4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
SX2_k127_2896919_0	269799.Gmet_1954	1.387e-158	514.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,43BKD@68525|delta/epsilon subdivisions,2WJNK@28221|Deltaproteobacteria,43T3U@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
SX2_k127_2909095_2	247490.KSU1_C0659	3.262e-15	78.0	COG0612@1|root,COG0612@2|Bacteria,2IWSI@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the peptidase M16 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
SX2_k127_2909095_1	1235279.C772_00638	1.199e-38	151.0	COG0742@1|root,COG0742@2|Bacteria,1V3JF@1239|Firmicutes,4HGXT@91061|Bacilli,26EZ2@186818|Planococcaceae	91061|Bacilli	L	Ribosomal RNA large subunit methyltransferase D, RlmJ	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
SX2_k127_2909095_0	1379698.RBG1_1C00001G0439	3.206e-54	195.0	COG0669@1|root,COG0669@2|Bacteria,2NPDV@2323|unclassified Bacteria	2|Bacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0004595,GO:0006082,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0051186,GO:0051188,GO:0070566,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
SX2_k127_2909095_3	1423732.BALS01000035_gene260	3.77e-06	49.0	COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,4H9X4@91061|Bacilli,3F439@33958|Lactobacillaceae	91061|Bacilli	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
SX2_k127_291796_0	518766.Rmar_0075	5.349e-98	331.0	COG0213@1|root,COG0213@2|Bacteria,4NFVB@976|Bacteroidetes,1FJ42@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	F	Pyrimidine nucleoside phosphorylase C-terminal domain	-	-	2.4.2.2,2.4.2.4	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R01876,R02296,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
SX2_k127_291796_1	35841.BT1A1_2257	3.951e-44	166.0	COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,4HAAJ@91061|Bacilli,1ZCZ6@1386|Bacillus	91061|Bacilli	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC,NUDIX
SX2_k127_291796_3	1397699.JNIS01000001_gene2332	2.332e-06	52.0	COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,4HAAJ@91061|Bacilli,3WEJ4@539002|Bacillales incertae sedis	91061|Bacilli	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
SX2_k127_291796_2	1191523.MROS_2464	2.315e-31	127.0	COG0295@1|root,COG0295@2|Bacteria	2|Bacteria	F	cytidine deaminase activity	cdd	GO:0001882,GO:0001884,GO:0003674,GO:0003824,GO:0004126,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006216,GO:0006217,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008655,GO:0009056,GO:0009058,GO:0009116,GO:0009119,GO:0009120,GO:0009164,GO:0009972,GO:0009987,GO:0015949,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0036094,GO:0042454,GO:0042802,GO:0043094,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046087,GO:0046092,GO:0046121,GO:0046125,GO:0046127,GO:0046131,GO:0046133,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0047844,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0097159,GO:0097367,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	iECO103_1326.ECO103_2618	dCMP_cyt_deam_1,dCMP_cyt_deam_2
SX2_k127_291796_4	1379698.RBG1_1C00001G0405	5.121e-06	49.0	COG4784@1|root,COG4784@2|Bacteria,2NS4E@2323|unclassified Bacteria	2|Bacteria	S	Peptidase family M48	MA20_40030	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M48
SX2_k127_2933373_0	237368.SCABRO_03474	1.569e-40	163.0	COG0612@1|root,COG0612@2|Bacteria,2IYKK@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Peptidase M16 inactive domain	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
SX2_k127_2939680_1	1293054.HSACCH_02593	0.0009163	43.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,3WB1D@53433|Halanaerobiales	186801|Clostridia	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695,ko:K03696	ko01100,ko04213,map01100,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
SX2_k127_2939680_0	1304284.L21TH_0674	4.122e-25	117.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,36DBS@31979|Clostridiaceae	186801|Clostridia	KLT	serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
SX2_k127_2968085_5	1379698.RBG1_1C00001G1591	1.185e-29	123.0	COG0091@1|root,COG0091@2|Bacteria,2NPNW@2323|unclassified Bacteria	2|Bacteria	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
SX2_k127_2968085_4	762903.Pedsa_2144	5.877e-42	155.0	COG0185@1|root,COG0185@2|Bacteria,4NQ8T@976|Bacteroidetes,1ISXF@117747|Sphingobacteriia	976|Bacteroidetes	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
SX2_k127_2968085_0	1379698.RBG1_1C00001G1593	1.348e-123	400.0	COG0090@1|root,COG0090@2|Bacteria,2NNR3@2323|unclassified Bacteria	2|Bacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
SX2_k127_2968085_7	572479.Hprae_1685	3.039e-20	93.0	COG0089@1|root,COG0089@2|Bacteria,1VA4W@1239|Firmicutes,24MN8@186801|Clostridia,3WATR@53433|Halanaerobiales	186801|Clostridia	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
SX2_k127_2968085_2	562970.Btus_0154	1.855e-56	203.0	COG0088@1|root,COG0088@2|Bacteria,1TPGW@1239|Firmicutes,4HB01@91061|Bacilli,2789A@186823|Alicyclobacillaceae	91061|Bacilli	J	Forms part of the polypeptide exit tunnel	rplD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
SX2_k127_2968085_1	1379698.RBG1_1C00001G1596	5.677e-66	231.0	COG0087@1|root,COG0087@2|Bacteria,2NPAI@2323|unclassified Bacteria	2|Bacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0015934,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031323,GO:0031325,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000232,GO:2000234	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
SX2_k127_2968085_3	1379698.RBG1_1C00001G1598	8.855e-45	164.0	COG0051@1|root,COG0051@2|Bacteria,2NPJY@2323|unclassified Bacteria	2|Bacteria	J	Involved in the binding of tRNA to the ribosomes	rpsJ	GO:0001072,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0015935,GO:0019219,GO:0019222,GO:0019538,GO:0022626,GO:0022627,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043244,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0140110,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2001141	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
SX2_k127_2968085_6	404589.Anae109_2229	1.514e-25	106.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2WJ2B@28221|Deltaproteobacteria,2YX6I@29|Myxococcales	28221|Deltaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
SX2_k127_2970027_0	1166018.FAES_4873	1.291e-89	322.0	COG0308@1|root,COG0308@2|Bacteria,4NG5Q@976|Bacteroidetes,47JW1@768503|Cytophagia	976|Bacteroidetes	E	Peptidase M1, membrane alanine aminopeptidase	pepN1	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M1
SX2_k127_2970144_0	457570.Nther_2188	5.697e-86	305.0	COG4805@1|root,COG4805@2|Bacteria	2|Bacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
SX2_k127_2981660_1	1227739.Hsw_3692	2.579e-54	194.0	COG1914@1|root,COG1914@2|Bacteria,4NENE@976|Bacteroidetes,47N3X@768503|Cytophagia	976|Bacteroidetes	P	H( )-stimulated, divalent metal cation uptake system	mntH	-	-	ko:K03322	-	-	-	-	ko00000,ko02000	2.A.55.2.6,2.A.55.3	-	-	Nramp
SX2_k127_2981660_3	67352.JODS01000031_gene834	3.125e-06	57.0	COG0500@1|root,COG2226@2|Bacteria,2I8CF@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
SX2_k127_2981660_0	880072.Desac_1646	1.443e-64	231.0	COG0726@1|root,COG0726@2|Bacteria,1MWMZ@1224|Proteobacteria,42P7W@68525|delta/epsilon subdivisions,2WMHU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	TIGRFAM polysaccharide deactylase family protein, PEP-CTERM locus subfamily	-	-	-	-	-	-	-	-	-	-	-	-	DUF3473,Polysacc_deac_1
SX2_k127_2981660_2	78245.Xaut_3520	1.546e-07	64.0	COG1494@1|root,COG1494@2|Bacteria,1MUB1@1224|Proteobacteria,2TSPE@28211|Alphaproteobacteria,3EYMP@335928|Xanthobacteraceae	28211|Alphaproteobacteria	G	Bacterial fructose-1,6-bisphosphatase, glpX-encoded	glpX	-	3.1.3.11,3.1.3.37	ko:K02446,ko:K11532	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R01845,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
SX2_k127_2985813_0	204669.Acid345_1514	7.308e-98	336.0	COG1132@1|root,COG1132@2|Bacteria,3Y32T@57723|Acidobacteria,2JIBZ@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter, transmembrane	-	-	-	ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
SX2_k127_2985813_2	1379698.RBG1_1C00001G0559	2.519e-28	121.0	COG1656@1|root,COG1656@2|Bacteria,2NPUJ@2323|unclassified Bacteria	2|Bacteria	H	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C,Ub-Mut7C
SX2_k127_2985813_1	595460.RRSWK_05351	1.364e-63	233.0	COG1449@1|root,COG1449@2|Bacteria,2IY67@203682|Planctomycetes	203682|Planctomycetes	G	Belongs to the glycosyl hydrolase 57 family	-	-	2.4.1.25	ko:K22451	ko00500,map00500	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH57	-	DUF1925,DUF1926,Glyco_hydro_57
SX2_k127_2998266_1	1379698.RBG1_1C00001G0361	6.023e-65	230.0	COG0530@1|root,COG0530@2|Bacteria,2NPSH@2323|unclassified Bacteria	2|Bacteria	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
SX2_k127_2998266_2	309807.SRU_1207	1.838e-11	76.0	COG2067@1|root,COG2067@2|Bacteria,4NDZW@976|Bacteroidetes,1FIMP@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_2998266_0	1379698.RBG1_1C00001G0216	2.537e-75	263.0	COG0845@1|root,COG0845@2|Bacteria,2NPBH@2323|unclassified Bacteria	2|Bacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_D23
SX2_k127_3000248_0	1191523.MROS_0520	4.305e-27	123.0	COG2911@1|root,COG2911@2|Bacteria	2|Bacteria	S	protein secretion	-	-	-	ko:K15125	ko05133,map05133	-	-	-	ko00000,ko00001,ko00536	-	-	-	Porin_2
SX2_k127_3020256_1	1521187.JPIM01000120_gene293	2.619e-45	171.0	COG1921@1|root,COG1921@2|Bacteria,2G5VV@200795|Chloroflexi,376BM@32061|Chloroflexia	32061|Chloroflexia	H	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
SX2_k127_3020256_0	479434.Sthe_1974	4.897e-97	331.0	COG3276@1|root,COG3276@2|Bacteria,2G5JX@200795|Chloroflexi,27XRW@189775|Thermomicrobia	189775|Thermomicrobia	J	Elongation factor SelB, winged helix	-	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
SX2_k127_30379_2	1265310.CCBD010000007_gene3233	0.0001145	48.0	COG0524@1|root,COG0524@2|Bacteria,2GP1C@201174|Actinobacteria,237N3@1762|Mycobacteriaceae	201174|Actinobacteria	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
SX2_k127_30379_0	880073.Calab_0513	6.52e-111	382.0	2C3GN@1|root,31EWU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_30379_1	404589.Anae109_3101	1.802e-35	138.0	COG0531@1|root,COG0531@2|Bacteria,1R829@1224|Proteobacteria,42MS5@68525|delta/epsilon subdivisions,2WINQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
SX2_k127_3061678_3	880073.Calab_0112	4.607e-22	109.0	COG4775@1|root,COG4775@2|Bacteria,2NPNI@2323|unclassified Bacteria	2|Bacteria	M	Surface antigen	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
SX2_k127_3061678_2	1379698.RBG1_1C00001G1781	2.012e-22	108.0	COG0382@1|root,COG0382@2|Bacteria,2NQZV@2323|unclassified Bacteria	2|Bacteria	H	UbiA prenyltransferase family	ubiA	-	2.5.1.39,2.5.1.42	ko:K03179,ko:K17105	ko00130,ko00564,ko01100,ko01110,map00130,map00564,map01100,map01110	M00117	R04520,R05000,R05615	RC00209,RC01171,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
SX2_k127_3061678_0	1379698.RBG1_1C00001G1779	3.031e-151	483.0	COG0714@1|root,COG0714@2|Bacteria,2NNMQ@2323|unclassified Bacteria	2|Bacteria	S	ATPase associated with various cellular	moxR	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
SX2_k127_3061678_1	1379698.RBG1_1C00001G1778	3.013e-113	372.0	COG1721@1|root,COG1721@2|Bacteria,2NNQI@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function DUF58	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF58
SX2_k127_3074125_0	1397528.Q671_16185	9.433e-39	157.0	COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,1RP16@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Secretion protein	ybhG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0071944	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
SX2_k127_3074125_1	637910.ROD_07941	2.701e-36	143.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,3WVYP@544|Citrobacter	1236|Gammaproteobacteria	V	ATPases associated with a variety of cellular activities	ybhF	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015562,GO:0015893,GO:0016020,GO:0022857,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX2_k127_3079076_1	880073.Calab_2774	7.179e-52	192.0	COG0325@1|root,COG0325@2|Bacteria,2NPEW@2323|unclassified Bacteria	2|Bacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	yggS	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
SX2_k127_3079076_2	1121439.dsat_0931	2.848e-16	85.0	COG3599@1|root,COG3599@2|Bacteria,1NCAV@1224|Proteobacteria,42VH6@68525|delta/epsilon subdivisions,2WPC4@28221|Deltaproteobacteria,2MBBV@213115|Desulfovibrionales	28221|Deltaproteobacteria	D	PFAM DivIVA family protein	-	-	-	ko:K04074	-	-	-	-	ko00000,ko03036	-	-	-	DivIVA
SX2_k127_3079076_0	1379698.RBG1_1C00001G0102	3.051e-124	403.0	COG0005@1|root,COG0005@2|Bacteria,2NP5F@2323|unclassified Bacteria	2|Bacteria	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	punA	-	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
SX2_k127_3079076_3	2903.EOD21925	0.0002416	44.0	COG0060@1|root,KOG0434@2759|Eukaryota	2759|Eukaryota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	ILERS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010035,GO:0010038,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017101,GO:0019538,GO:0019752,GO:0019899,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0042221,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046686,GO:0050896,GO:0051020,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iRC1080.CRv4_Au5_s16_g6096_t1	Anticodon_1,tRNA-synt_1
SX2_k127_308606_0	945713.IALB_1595	1.055e-60	216.0	COG0036@1|root,COG0036@2|Bacteria	2|Bacteria	G	ribulose-phosphate 3-epimerase activity	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
SX2_k127_308606_2	864563.HMPREF9166_0773	4.355e-27	120.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,4H2BH@909932|Negativicutes	909932|Negativicutes	KLT	serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
SX2_k127_308606_1	1379698.RBG1_1C00001G0941	7.177e-48	178.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,2NP36@2323|unclassified Bacteria	2|Bacteria	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	sun	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
SX2_k127_3097585_3	1116472.MGMO_45c00370	3.198e-07	57.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,1RMKP@1236|Gammaproteobacteria,1XDR2@135618|Methylococcales	135618|Methylococcales	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
SX2_k127_3097585_1	1379698.RBG1_1C00001G1158	2.342e-66	237.0	COG0196@1|root,COG0196@2|Bacteria,2NPCV@2323|unclassified Bacteria	2|Bacteria	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K07011,ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
SX2_k127_3097585_2	1121472.AQWN01000001_gene144	3.174e-29	118.0	COG0184@1|root,COG0184@2|Bacteria,1VA5C@1239|Firmicutes,24MRM@186801|Clostridia,262DU@186807|Peptococcaceae	186801|Clostridia	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
SX2_k127_3097585_0	1379698.RBG1_1C00001G1160	6.181e-257	807.0	COG1185@1|root,COG1185@2|Bacteria,2NNX7@2323|unclassified Bacteria	2|Bacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
SX2_k127_3101196_0	1379698.RBG1_1C00001G0460	1.413e-248	790.0	COG0587@1|root,COG0587@2|Bacteria,2NNVY@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase	dnaE	GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon
SX2_k127_3101196_1	1379698.RBG1_1C00001G0457	1.508e-71	248.0	COG0705@1|root,COG0705@2|Bacteria,2NPGI@2323|unclassified Bacteria	2|Bacteria	S	(Rhomboid) family	GlpG	-	-	ko:K07059	-	-	-	-	ko00000	-	-	-	Rhomboid
SX2_k127_3101196_2	1144313.PMI10_00701	1.674e-06	59.0	COG0739@1|root,COG0739@2|Bacteria,4NED7@976|Bacteroidetes,1HXKD@117743|Flavobacteriia,2NT69@237|Flavobacterium	976|Bacteroidetes	M	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
SX2_k127_3112121_1	290397.Adeh_3688	2.669e-13	82.0	COG0457@1|root,COG0745@1|root,COG0457@2|Bacteria,COG0745@2|Bacteria,1NVZF@1224|Proteobacteria,42ZUK@68525|delta/epsilon subdivisions,2X7NR@28221|Deltaproteobacteria,2Z3H7@29|Myxococcales	28221|Deltaproteobacteria	T	Domain of unknown function (DUF4388)	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF4388,Response_reg
SX2_k127_3112121_0	1304284.L21TH_0121	1.472e-50	184.0	COG1164@1|root,COG1164@2|Bacteria,1TP4P@1239|Firmicutes,248TP@186801|Clostridia,36DG9@31979|Clostridiaceae	186801|Clostridia	E	oligoendopeptidase F	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
SX2_k127_3154312_1	330214.NIDE3411	7.54e-05	52.0	COG0457@1|root,COG0457@2|Bacteria	330214.NIDE3411|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_3154312_0	1123234.AUKI01000011_gene1311	2.854e-08	62.0	COG1595@1|root,COG1595@2|Bacteria,4NFXX@976|Bacteroidetes,1HZT5@117743|Flavobacteriia	976|Bacteroidetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SX2_k127_3154545_0	1379698.RBG1_1C00001G1336	8.547e-83	287.0	COG3264@1|root,COG3264@2|Bacteria,2NPZR@2323|unclassified Bacteria	2|Bacteria	M	Mechanosensitive ion channel	mscS-1	-	-	ko:K05802,ko:K16052,ko:K22051	-	-	-	-	ko00000,ko02000	1.A.23.1.1,1.A.23.1.2,1.A.23.1.3,1.A.23.4	-	-	MS_channel,TM_helix
SX2_k127_3154545_1	880073.Calab_2056	1.825e-08	62.0	COG2372@1|root,COG2372@2|Bacteria,2NQ3Q@2323|unclassified Bacteria	2|Bacteria	S	Bacterial Ig-like domain	-	-	-	ko:K07156	-	-	-	-	ko00000,ko02000	9.B.62.2	-	-	Big_5,DUF4082,SLH
SX2_k127_3155558_0	1379698.RBG1_1C00001G0692	1.528e-116	379.0	COG0216@1|root,COG0216@2|Bacteria,2NNKY@2323|unclassified Bacteria	2|Bacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
SX2_k127_3156498_0	1379698.RBG1_1C00001G1165	6.531e-264	829.0	COG0495@1|root,COG0495@2|Bacteria,2NNQH@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iAF987.Gmet_2300	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
SX2_k127_3164671_1	269799.Gmet_0890	8.369e-08	57.0	COG0758@1|root,COG1948@1|root,COG0758@2|Bacteria,COG1948@2|Bacteria,1MVF6@1224|Proteobacteria,42N10@68525|delta/epsilon subdivisions,2WJI9@28221|Deltaproteobacteria,43U42@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	TIGRFAM DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
SX2_k127_3164671_0	1191523.MROS_0455	2.451e-104	348.0	COG0536@1|root,COG0536@2|Bacteria	2|Bacteria	C	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	GO:0000003,GO:0000160,GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007059,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019538,GO:0019954,GO:0022607,GO:0022611,GO:0022613,GO:0022618,GO:0023052,GO:0030436,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0034622,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0040007,GO:0042254,GO:0042255,GO:0043021,GO:0043022,GO:0043023,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0043933,GO:0043934,GO:0044085,GO:0044087,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090069,GO:0090071,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1990904	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
SX2_k127_316709_0	1125863.JAFN01000001_gene2568	1.81e-18	99.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,42MPK@68525|delta/epsilon subdivisions,2WJM1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	peptidyl-prolyl isomerase	nifM	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
SX2_k127_316709_1	1379698.RBG1_1C00001G0462	5.825e-11	64.0	COG2067@1|root,COG2067@2|Bacteria,2NPVZ@2323|unclassified Bacteria	2|Bacteria	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_3170910_0	1340434.AXVA01000005_gene4718	2.756e-54	196.0	COG1164@1|root,COG1164@2|Bacteria,1TQ5W@1239|Firmicutes,4HAN9@91061|Bacilli,1ZCRR@1386|Bacillus	91061|Bacilli	E	COG1164 Oligoendopeptidase F	pepF2	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M3,Peptidase_M3_N
SX2_k127_3170910_1	8153.XP_005947569.1	7.353e-08	64.0	COG0457@1|root,KOG1124@2759|Eukaryota,38CY4@33154|Opisthokonta,3BAFG@33208|Metazoa,3CV6Z@33213|Bilateria,480W8@7711|Chordata,4967I@7742|Vertebrata,49V00@7898|Actinopterygii	33208|Metazoa	S	Transmembrane and tetratricopeptide repeat containing 3	TMTC3	GO:0001763,GO:0002009,GO:0003401,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0006950,GO:0007275,GO:0008150,GO:0009653,GO:0009791,GO:0009887,GO:0009888,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010468,GO:0010604,GO:0012505,GO:0019222,GO:0030154,GO:0030162,GO:0030323,GO:0030324,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0032268,GO:0032270,GO:0032501,GO:0032502,GO:0033554,GO:0034976,GO:0035239,GO:0035295,GO:0040007,GO:0042176,GO:0042692,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0045732,GO:0045862,GO:0048286,GO:0048468,GO:0048513,GO:0048518,GO:0048522,GO:0048589,GO:0048729,GO:0048731,GO:0048747,GO:0048754,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051146,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051716,GO:0055001,GO:0055002,GO:0060255,GO:0060425,GO:0060429,GO:0060441,GO:0060447,GO:0060541,GO:0060560,GO:0060562,GO:0060602,GO:0061061,GO:0061136,GO:0061138,GO:0065007,GO:0080090,GO:1901800,GO:1903050,GO:1903052,GO:1903362,GO:1903364	-	-	-	-	-	-	-	-	-	-	DUF1736,TPR_1,TPR_16,TPR_2,TPR_6,TPR_8
SX2_k127_3171133_1	479434.Sthe_1708	3.581e-13	74.0	2DPX2@1|root,333RW@2|Bacteria,2G7A0@200795|Chloroflexi,27Z8D@189775|Thermomicrobia	189775|Thermomicrobia	S	Protein of unknown function (DUF4013)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4013
SX2_k127_3171133_2	1144307.PMI04_03071	1.275e-09	69.0	COG0823@1|root,COG0823@2|Bacteria,1R6I6@1224|Proteobacteria	1224|Proteobacteria	U	Periplasmic component of the Tol biopolymer transport system	-	-	-	-	-	-	-	-	-	-	-	-	PD40
SX2_k127_3171133_0	509191.AEDB02000109_gene4960	1.664e-34	139.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia,3WIW4@541000|Ruminococcaceae	186801|Clostridia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	algU	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SX2_k127_3172070_0	1379698.RBG1_1C00001G1107	5.402e-30	129.0	COG1207@1|root,COG1207@2|Bacteria,2NQ8F@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_4
SX2_k127_3172070_1	765869.BDW_06890	7.11e-14	75.0	2EH48@1|root,33AW7@2|Bacteria,1NIYU@1224|Proteobacteria,42XKK@68525|delta/epsilon subdivisions,2MT7I@213481|Bdellovibrionales,2WSKU@28221|Deltaproteobacteria	213481|Bdellovibrionales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_3174323_6	1379698.RBG1_1C00001G1824	1.472e-66	233.0	COG0304@1|root,COG0304@2|Bacteria,2NNSX@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179,2.3.1.41	ko:K00647,ko:K09458,ko:K14660	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iSB619.SA_RS04785	Ketoacyl-synt_C,ketoacyl-synt
SX2_k127_3174323_7	387092.NIS_0314	2.195e-26	109.0	COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,42V9M@68525|delta/epsilon subdivisions,2YPX3@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
SX2_k127_3174323_5	880073.Calab_0618	5.01e-81	276.0	COG1028@1|root,COG1028@2|Bacteria,2NP35@2323|unclassified Bacteria	2|Bacteria	IQ	Enoyl-(Acyl carrier protein) reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SX2_k127_3174323_4	1379698.RBG1_1C00001G1827	9.606e-90	309.0	COG0331@1|root,COG0331@2|Bacteria,2NP3V@2323|unclassified Bacteria	2|Bacteria	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645,ko:K15327,ko:K15329,ko:K15355,ko:K15469	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	-	-	-	Acyl_transf_1
SX2_k127_3174323_2	1123070.KB899248_gene6	3.024e-103	345.0	COG0332@1|root,COG0332@2|Bacteria,46SE2@74201|Verrucomicrobia,2ITMR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
SX2_k127_3174323_3	1379698.RBG1_1C00001G1828	6.059e-96	325.0	COG0416@1|root,COG0416@2|Bacteria,2NP1H@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
SX2_k127_3174323_9	1379698.RBG1_1C00001G1829	1.367e-16	80.0	COG0333@1|root,COG0333@2|Bacteria,2NQ1M@2323|unclassified Bacteria	2|Bacteria	J	Ribosomal L32p protein family	rpmF	GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
SX2_k127_3174323_8	1379698.RBG1_1C00001G1830	3.043e-23	106.0	COG1399@1|root,COG1399@2|Bacteria,2NPVD@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterized ACR, COG1399	yceD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
SX2_k127_3174323_0	880073.Calab_0624	4.149e-158	507.0	COG0282@1|root,COG0282@2|Bacteria,2NNXT@2323|unclassified Bacteria	2|Bacteria	C	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0409	Acetate_kinase
SX2_k127_3174323_1	880073.Calab_0626	8.559e-109	359.0	COG1250@1|root,COG1250@2|Bacteria,2NQAW@2323|unclassified Bacteria	2|Bacteria	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	hbd2	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
SX2_k127_3188343_0	522306.CAP2UW1_0858	1.043e-97	327.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,2VMX7@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	algD	-	1.1.1.132	ko:K00066	ko00051,ko00520,ko02020,map00051,map00520,map02020	-	R00880	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
SX2_k127_3188343_1	941449.dsx2_1182	3.071e-69	248.0	COG1215@1|root,COG1215@2|Bacteria,1NDPE@1224|Proteobacteria,439Z2@68525|delta/epsilon subdivisions,2X1YW@28221|Deltaproteobacteria,2M834@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SX2_k127_3188343_2	1121439.dsat_1283	1.284e-56	212.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,42T1S@68525|delta/epsilon subdivisions,2WPVE@28221|Deltaproteobacteria,2MG45@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
SX2_k127_3190727_2	1168034.FH5T_11060	4.418e-14	80.0	COG1305@1|root,COG1305@2|Bacteria	2|Bacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
SX2_k127_3190727_1	435908.IDSA_07050	4.238e-25	108.0	COG3655@1|root,COG3655@2|Bacteria,1N6VH@1224|Proteobacteria,1SDAJ@1236|Gammaproteobacteria,2QGYY@267893|Idiomarinaceae	1236|Gammaproteobacteria	K	Cro/C1-type HTH DNA-binding domain	yozG	-	-	ko:K07727	-	-	-	-	ko00000,ko03000	-	-	-	HTH_26
SX2_k127_3190727_0	1379698.RBG1_1C00001G1218	7.055e-46	178.0	COG0515@1|root,COG0515@2|Bacteria,2NQWH@2323|unclassified Bacteria	2|Bacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_8
SX2_k127_3196669_1	643648.Slip_1894	1.461e-29	122.0	28JE3@1|root,2Z98B@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
SX2_k127_3196669_0	56780.SYN_01455	4.538e-184	583.0	COG3033@1|root,COG3033@2|Bacteria,1NG5U@1224|Proteobacteria,42QJ3@68525|delta/epsilon subdivisions,2WKUT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Beta-eliminating lyase	-	-	4.1.99.1	ko:K01667	ko00380,map00380	-	R00673	RC00209,RC00355	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
SX2_k127_321005_0	1379698.RBG1_1C00001G1562	1.081e-138	454.0	COG5009@1|root,COG5009@2|Bacteria,2NS4K@2323|unclassified Bacteria	2|Bacteria	M	Transglycosylase	mrcA	GO:0003674,GO:0005488,GO:0005515,GO:0042802	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	iAF987.Gmet_0354	PCB_OB,Transgly,Transpeptidase
SX2_k127_3222606_0	1379698.RBG1_1C00001G1524	1.472e-58	224.0	COG2911@1|root,COG2911@2|Bacteria,2NQ89@2323|unclassified Bacteria	2|Bacteria	S	TamB, inner membrane protein subunit of TAM complex	-	-	-	ko:K07277,ko:K09800	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	AsmA_2,DUF748,TamB
SX2_k127_3222606_2	861299.J421_3473	1.124e-16	88.0	COG0599@1|root,COG0599@2|Bacteria,1ZTPF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Carboxymuconolactone decarboxylase family	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
SX2_k127_3222606_1	945713.IALB_1477	1.797e-18	94.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	ko:K13276	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	Peptidase_S8
SX2_k127_3228647_0	382464.ABSI01000012_gene2139	2.634e-17	94.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,VPEP
SX2_k127_323496_2	1379698.RBG1_1C00001G1488	1.477e-64	226.0	COG0484@1|root,COG0484@2|Bacteria,2NNNG@2323|unclassified Bacteria	2|Bacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0000988,GO:0000989,GO:0003674,GO:0003756,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010556,GO:0015035,GO:0015036,GO:0016020,GO:0016032,GO:0016043,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0016989,GO:0019219,GO:0019222,GO:0022607,GO:0031323,GO:0031326,GO:0032991,GO:0034641,GO:0034645,GO:0042026,GO:0043167,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051704,GO:0055114,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0140096,GO:0140110,GO:1901360,GO:1901576,GO:1903506,GO:2001141	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
SX2_k127_323496_0	1379698.RBG1_1C00001G1489	6.376e-298	925.0	COG0443@1|root,COG0443@2|Bacteria,2NNU1@2323|unclassified Bacteria	2|Bacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
SX2_k127_323496_3	768704.Desmer_4003	4.727e-36	145.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,24MQK@186801|Clostridia,26214@186807|Peptococcaceae	186801|Clostridia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
SX2_k127_323496_1	1379698.RBG1_1C00001G1491	8.567e-108	359.0	COG1420@1|root,COG1420@2|Bacteria,2NPAK@2323|unclassified Bacteria	2|Bacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HTH_DeoR,HrcA,HrcA_DNA-bdg
SX2_k127_3237110_0	1379698.RBG1_1C00001G1445	4.1e-12	70.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,2NQSG@2323|unclassified Bacteria	2|Bacteria	MU	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641,ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33,2.C.1.2	-	-	BSP,Bac_surface_Ag,PD40,Peptidase_MA_2
SX2_k127_3239789_6	1121335.Clst_0527	4.21e-29	118.0	COG1994@1|root,COG1994@2|Bacteria,1V6D4@1239|Firmicutes,24K0D@186801|Clostridia,3WJN0@541000|Ruminococcaceae	186801|Clostridia	S	peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
SX2_k127_3239789_2	1379698.RBG1_1C00001G1028	6.232e-57	205.0	COG2094@1|root,COG2094@2|Bacteria,2NPMI@2323|unclassified Bacteria	2|Bacteria	L	Belongs to the DNA glycosylase MPG family	mpg	GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
SX2_k127_3239789_3	635013.TherJR_1575	3.19e-49	186.0	COG1387@1|root,COG1387@2|Bacteria,1TRKS@1239|Firmicutes,249TM@186801|Clostridia,26325@186807|Peptococcaceae	186801|Clostridia	E	histidinol phosphate phosphatase	-	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP
SX2_k127_3239789_1	868595.Desca_2265	2.651e-65	231.0	COG0491@1|root,COG0491@2|Bacteria,1V6FA@1239|Firmicutes,24JGV@186801|Clostridia,261Y2@186807|Peptococcaceae	186801|Clostridia	P	PFAM Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SX2_k127_3239789_4	1283300.ATXB01000002_gene3120	3.856e-36	141.0	COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,1THNZ@1236|Gammaproteobacteria,1XF4B@135618|Methylococcales	135618|Methylococcales	S	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
SX2_k127_3239789_0	1125863.JAFN01000001_gene2317	4.922e-94	314.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,42MKZ@68525|delta/epsilon subdivisions,2WING@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	iAF987.Gmet_3075	QueC
SX2_k127_3239789_5	984262.SGRA_1080	3.531e-31	131.0	COG0602@1|root,COG0602@2|Bacteria	2|Bacteria	H	queuosine metabolic process	queE	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008144,GO:0016829,GO:0016840,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:1901681,GO:1904047	1.97.1.4,4.3.99.3	ko:K04068,ko:K10026	ko00790,ko01100,map00790,map01100	-	R04710,R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_12,Fer4_14,Radical_SAM
SX2_k127_3249502_0	880073.Calab_0921	6.381e-20	91.0	COG1361@1|root,COG1361@2|Bacteria	2|Bacteria	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157,FctA,Peptidase_M43
SX2_k127_3252627_3	290397.Adeh_3683	2.286e-22	98.0	COG1428@1|root,COG1428@2|Bacteria,1RC50@1224|Proteobacteria	1224|Proteobacteria	F	Deoxynucleoside kinase	dgk	-	-	-	-	-	-	-	-	-	-	-	dNK
SX2_k127_3252627_2	204669.Acid345_0083	1.078e-35	141.0	COG0801@1|root,COG0801@2|Bacteria,3Y57F@57723|Acidobacteria,2JJMS@204432|Acidobacteriia	204432|Acidobacteriia	H	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)	-	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
SX2_k127_3252627_0	1379698.RBG1_1C00001G0302	2.468e-43	162.0	COG1539@1|root,COG1539@2|Bacteria,2NQ1A@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folB	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
SX2_k127_3252627_1	694431.DESACE_06110	2.54e-40	164.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42MEF@68525|delta/epsilon subdivisions,2WJ4D@28221|Deltaproteobacteria,2M6A7@213113|Desulfurellales	28221|Deltaproteobacteria	E	Aminotransferase class I and II	yfdZ	-	2.6.1.83	ko:K10206,ko:K14261	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
SX2_k127_3262641_1	643867.Ftrac_2139	2.457e-13	83.0	COG4288@1|root,COG4288@2|Bacteria,4NHM6@976|Bacteroidetes,47KV2@768503|Cytophagia	976|Bacteroidetes	M	Lamin Tail Domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,CHU_C,LTD
SX2_k127_3262641_2	1120965.AUBV01000001_gene3263	1.446e-07	62.0	COG1555@1|root,COG1555@2|Bacteria,4NVH1@976|Bacteroidetes,47XU1@768503|Cytophagia	976|Bacteroidetes	L	photosystem II stabilization	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_3262641_0	1379698.RBG1_1C00001G1870	1.286e-122	405.0	COG0232@1|root,COG0232@2|Bacteria,2NP3S@2323|unclassified Bacteria	2|Bacteria	F	Phosphohydrolase-associated domain	dgt	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
SX2_k127_3262641_3	1379698.RBG1_1C00001G1377	4.675e-06	49.0	COG4409@1|root,COG4409@2|Bacteria,2NRD7@2323|unclassified Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	ASH,BNR_2,Big_3_2,CBM_35,DUF1080,F5_F8_type_C,PKD,RicinB_lectin_2,Trehalase
SX2_k127_3268751_1	926554.KI912633_gene3916	1.251e-77	267.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
SX2_k127_3268751_0	1379698.RBG1_1C00001G1659	3.886e-109	373.0	COG2812@1|root,COG2812@2|Bacteria,2NNK7@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
SX2_k127_3268751_2	886293.Sinac_1729	1.142e-72	254.0	COG0501@1|root,COG0501@2|Bacteria,2J0GY@203682|Planctomycetes	203682|Planctomycetes	O	CAAX prenyl protease N-terminal, five membrane helices	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,Peptidase_M48_N
SX2_k127_326887_0	459349.CLOAM0275	2.171e-33	142.0	COG1413@1|root,COG1413@2|Bacteria,2NQWQ@2323|unclassified Bacteria	2|Bacteria	C	lyase activity	-	-	3.4.24.3	ko:K01387,ko:K03301	-	-	-	-	ko00000,ko01000,ko01002,ko02042	2.A.12	-	-	DUF1822,DUF4132,HEAT_2,HEAT_PBS,Peptidase_M9,Peptidase_M9_N,Sulfatase
SX2_k127_3269870_1	383372.Rcas_1593	1.855e-50	182.0	COG0846@1|root,COG0846@2|Bacteria,2G6QQ@200795|Chloroflexi,375GJ@32061|Chloroflexia	32061|Chloroflexia	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
SX2_k127_3269870_2	1379698.RBG1_1C00001G0229	3.884e-25	114.0	2BIY5@1|root,32D6E@2|Bacteria,2NRW7@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_3269870_0	398767.Glov_1510	1.235e-70	243.0	COG0673@1|root,COG0673@2|Bacteria,1PXE1@1224|Proteobacteria,42MSE@68525|delta/epsilon subdivisions,2WKIS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	1.1.1.335	ko:K13016	ko00520,map00520	-	R10140	RC00182	ko00000,ko00001,ko01000,ko01005	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX2_k127_3275616_1	1209989.TepiRe1_2652	1.492e-41	162.0	COG0543@1|root,COG0543@2|Bacteria,1TQ5D@1239|Firmicutes,24AY2@186801|Clostridia,42GEQ@68295|Thermoanaerobacterales	186801|Clostridia	C	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
SX2_k127_3275616_0	1379698.RBG1_1C00001G0226	4.583e-64	238.0	COG1729@1|root,COG1729@2|Bacteria,2NPUR@2323|unclassified Bacteria	2|Bacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TPR_8
SX2_k127_3294910_0	1191523.MROS_1932	2.064e-122	403.0	COG0249@1|root,COG0249@2|Bacteria	2|Bacteria	L	mismatched DNA binding	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
SX2_k127_3294910_1	1379698.RBG1_1C00001G1139	1.145e-121	412.0	COG0323@1|root,COG0323@2|Bacteria,2NNP7@2323|unclassified Bacteria	2|Bacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
SX2_k127_3294910_2	1304880.JAGB01000001_gene246	9.326e-68	241.0	COG0324@1|root,COG0324@2|Bacteria,1TPSC@1239|Firmicutes,248HB@186801|Clostridia	186801|Clostridia	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
SX2_k127_3294910_3	1379698.RBG1_1C00001G1141	3.138e-58	213.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,2NP1D@2323|unclassified Bacteria	2|Bacteria	M	Transglycosylase SLT domain	CP_0155	-	-	ko:K08307,ko:K12204	-	-	-	-	ko00000,ko01000,ko01011,ko02044	3.A.7.10.1,3.A.7.9.1	-	-	LysM,SLT,T4SS_TraI
SX2_k127_3296684_0	1191523.MROS_0223	6.274e-191	612.0	COG0085@1|root,COG0085@2|Bacteria	2|Bacteria	K	DNA-directed 5'-3' RNA polymerase activity	rpoB	GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03043,ko:K13797	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
SX2_k127_3372165_0	1379698.RBG1_1C00001G0494	1.275e-180	578.0	COG0272@1|root,COG0272@2|Bacteria,2NNSW@2323|unclassified Bacteria	2|Bacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
SX2_k127_339668_1	1379698.RBG1_1C00001G1875	1.459e-43	159.0	COG1143@1|root,COG1143@2|Bacteria,2NPQR@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.6.5.3	ko:K00337,ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iNJ661.Rv3153	Fer4
SX2_k127_339668_2	1379698.RBG1_1C00001G1058	9.505e-38	149.0	COG0839@1|root,COG0839@2|Bacteria,2NPUC@2323|unclassified Bacteria	2|Bacteria	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
SX2_k127_339668_3	1379698.RBG1_1C00001G1059	2.129e-31	125.0	COG0713@1|root,COG0713@2|Bacteria,2NPU2@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204	1.6.5.3	ko:K00340,ko:K05576	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
SX2_k127_339668_0	1379698.RBG1_1C00001G1060	2.082e-228	720.0	COG1009@1|root,COG1009@2|Bacteria,2NNU6@2323|unclassified Bacteria	2|Bacteria	CP	NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit	nuoL-1	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
SX2_k127_3401252_0	1379698.RBG1_1C00001G1638	2.466e-16	84.0	COG2304@1|root,COG2304@2|Bacteria,2NPZ4@2323|unclassified Bacteria	2|Bacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2135,DUF2828,VIT
SX2_k127_3401252_1	290317.Cpha266_0084	3.593e-10	64.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
SX2_k127_3421965_0	1379698.RBG1_1C00001G1482	4.411e-123	412.0	COG1193@1|root,COG1193@2|Bacteria,2NNS1@2323|unclassified Bacteria	2|Bacteria	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
SX2_k127_3436546_2	1519464.HY22_10300	1.257e-12	71.0	COG1596@1|root,COG1596@2|Bacteria	2|Bacteria	M	polysaccharide export	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
SX2_k127_3436546_1	2325.TKV_c06650	1.083e-84	287.0	COG1044@1|root,COG1044@2|Bacteria,1UHYP@1239|Firmicutes,25E78@186801|Clostridia,42J5I@68295|Thermoanaerobacterales	186801|Clostridia	M	Hexapeptide repeat of succinyl-transferase	-	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2
SX2_k127_3436546_0	1379698.RBG1_1C00001G1539	9.03e-137	445.0	COG0399@1|root,COG0399@2|Bacteria,2NNS2@2323|unclassified Bacteria	2|Bacteria	E	Belongs to the DegT DnrJ EryC1 family	degT	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
SX2_k127_3469961_0	1379698.RBG1_1C00001G0475	1.86e-143	464.0	COG0045@1|root,COG0045@2|Bacteria,2NNQA@2323|unclassified Bacteria	2|Bacteria	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009361,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0042709,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494	6.2.1.5,6.2.1.9	ko:K01903,ko:K14067	ko00020,ko00630,ko00640,ko00660,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00346,M00374,M00620	R00405,R01256,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2261,iPC815.YPO1115,iUMNK88_1353.UMNK88_764,iYO844.BSU16090	ATP-grasp_2,Ligase_CoA
SX2_k127_3469961_1	1379698.RBG1_1C00001G0476	4.34e-131	428.0	COG0074@1|root,COG0074@2|Bacteria,2NNZD@2323|unclassified Bacteria	2|Bacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
SX2_k127_3472306_1	1267533.KB906738_gene2057	2.637e-49	188.0	COG4965@1|root,COG4965@2|Bacteria,3Y4RR@57723|Acidobacteria,2JJ91@204432|Acidobacteriia	204432|Acidobacteriia	U	Type II secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
SX2_k127_3472306_0	338963.Pcar_1752	1.669e-141	456.0	COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,42NAK@68525|delta/epsilon subdivisions,2WIYX@28221|Deltaproteobacteria,43SA4@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	PFAM type II secretion system protein E	-	-	-	ko:K02283,ko:K03609	-	-	-	-	ko00000,ko02035,ko02044,ko03036,ko04812	-	-	-	CbiA,FHA,T2SSE
SX2_k127_3491109_0	234267.Acid_0851	2.23e-122	406.0	COG0793@1|root,COG0793@2|Bacteria	2|Bacteria	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S41,Tricorn_C1
SX2_k127_3504948_1	880073.Calab_1128	9.979e-41	171.0	COG1404@1|root,COG1629@1|root,COG1404@2|Bacteria,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,Big_2,CBM_25,Calx-beta,P_proprotein,Peptidase_S8,SBBP,SLH,TonB_dep_Rec,VCBS
SX2_k127_3504948_0	62928.azo3774	7.677e-65	244.0	COG0515@1|root,COG0515@2|Bacteria,1P64D@1224|Proteobacteria	1224|Proteobacteria	KLT	serine threonine protein kinase	pkn9	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
SX2_k127_351381_0	1379698.RBG1_1C00001G0680	5.565e-08	62.0	2EGPU@1|root,31UHW@2|Bacteria,2NRWE@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_3522764_3	1499967.BAYZ01000088_gene5060	1.506e-05	49.0	COG2189@1|root,COG2189@2|Bacteria,2NP0F@2323|unclassified Bacteria	2|Bacteria	L	PFAM DNA methylase N-4 N-6	-	-	2.1.1.72	ko:K00571,ko:K07316	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Mrr_cat,N6_N4_Mtase
SX2_k127_3522764_0	1121430.JMLG01000014_gene1928	7.297e-102	340.0	COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia,2604F@186807|Peptococcaceae	186801|Clostridia	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
SX2_k127_3522764_2	592026.GCWU0000282_000990	3.291e-11	71.0	COG1695@1|root,COG1695@2|Bacteria,1V7HF@1239|Firmicutes,24MIA@186801|Clostridia	186801|Clostridia	K	transcriptional regulator, PadR family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
SX2_k127_3522764_1	1125863.JAFN01000001_gene3034	2.697e-91	319.0	COG2204@1|root,COG2206@1|root,COG2204@2|Bacteria,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,42MEJ@68525|delta/epsilon subdivisions,2X71A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	metal-dependent phosphohydrolase HD region	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HD,Response_reg
SX2_k127_3529455_0	1089553.Tph_c16690	4.194e-60	215.0	COG0082@1|root,COG0082@2|Bacteria,1TQ40@1239|Firmicutes,24998@186801|Clostridia,42F8N@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
SX2_k127_3529455_2	1007103.AFHW01000091_gene3350	8.522e-32	133.0	COG0703@1|root,COG0703@2|Bacteria,1VA6Z@1239|Firmicutes,4HKD6@91061|Bacilli,26Y94@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
SX2_k127_3529455_1	1408226.T233_00402	4.959e-54	203.0	COG0337@1|root,COG0337@2|Bacteria,1TPKZ@1239|Firmicutes,4HAKN@91061|Bacilli,4B00G@81852|Enterococcaceae	91061|Bacilli	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
SX2_k127_3529455_3	935557.ATYB01000014_gene1760	1.089e-15	78.0	COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,2U9BV@28211|Alphaproteobacteria,4BEHS@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
SX2_k127_3567796_0	1173028.ANKO01000114_gene6163	2.269e-18	89.0	COG3501@1|root,COG3501@2|Bacteria,1G6H3@1117|Cyanobacteria,1HBBA@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Phage-related baseplate assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_3568214_3	561230.PC1_1848	9.747e-08	57.0	COG0144@1|root,COG3270@1|root,COG0144@2|Bacteria,COG3270@2|Bacteria,1NAY1@1224|Proteobacteria,1RP74@1236|Gammaproteobacteria,1MQFX@122277|Pectobacterium	1236|Gammaproteobacteria	J	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA	rsmF	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.178	ko:K11392	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,Methyltranf_PUA
SX2_k127_3568214_0	714943.Mucpa_3912	5.164e-72	248.0	COG0220@1|root,COG0220@2|Bacteria,4NG4V@976|Bacteroidetes,1ISBF@117747|Sphingobacteriia	976|Bacteroidetes	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
SX2_k127_3568214_2	671143.DAMO_1259	3.004e-17	89.0	COG1309@1|root,COG1309@2|Bacteria,2NQ8G@2323|unclassified Bacteria	2|Bacteria	K	Bacterial regulatory proteins, tetR family	MA20_16815	-	-	-	-	-	-	-	-	-	-	-	TetR_N
SX2_k127_3568214_1	880073.Calab_1598	4.937e-37	157.0	COG0484@1|root,COG2864@1|root,COG0484@2|Bacteria,COG2864@2|Bacteria,2NQFM@2323|unclassified Bacteria	2|Bacteria	P	Prokaryotic cytochrome b561	cbcY	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Ni_hydr_CYTB,Paired_CXXCH_1,Rhodanese
SX2_k127_3594956_0	459349.CLOAM1019	7.912e-107	368.0	COG1132@1|root,COG1132@2|Bacteria	2|Bacteria	V	(ABC) transporter	-	-	3.6.3.44	ko:K06147,ko:K06148,ko:K11085,ko:K16787,ko:K18104,ko:K18889	ko01501,ko02010,map01501,map02010	M00582,M00700,M00707	-	-	ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	3.A.1,3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.117,3.A.1.123,3.A.1.21,3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_membrane,ABC_tran
SX2_k127_3594956_1	269799.Gmet_3416	2.267e-40	152.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42N2U@68525|delta/epsilon subdivisions,2WJRR@28221|Deltaproteobacteria,43TU4@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	ABC transporter transmembrane region	-	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SX2_k127_3602889_0	1304284.L21TH_0121	1.461e-62	220.0	COG1164@1|root,COG1164@2|Bacteria,1TP4P@1239|Firmicutes,248TP@186801|Clostridia,36DG9@31979|Clostridiaceae	186801|Clostridia	E	oligoendopeptidase F	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
SX2_k127_364521_1	945713.IALB_1773	3.674e-21	99.0	COG0607@1|root,COG0607@2|Bacteria	2|Bacteria	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	-	-	-	-	-	-	-	-	-	-	-	-	DUF5069,Lactamase_B,Rhodanese
SX2_k127_364521_0	1379698.RBG1_1C00001G0236	4.547e-30	125.0	COG2259@1|root,COG2259@2|Bacteria,2NRSH@2323|unclassified Bacteria	2|Bacteria	S	PFAM Methylamine utilisation protein MauE	mauE	-	-	-	-	-	-	-	-	-	-	-	MauE
SX2_k127_364521_2	485914.Hmuk_1143	2.781e-09	68.0	arCOG04555@1|root,arCOG04555@2157|Archaea,2XUY2@28890|Euryarchaeota,23TMB@183963|Halobacteria	183963|Halobacteria	S	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
SX2_k127_3661143_2	525898.Sdel_2224	6.848e-45	176.0	COG0535@1|root,COG0535@2|Bacteria,1PEYS@1224|Proteobacteria,42SNS@68525|delta/epsilon subdivisions,2YQGZ@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
SX2_k127_3661143_1	1274524.BSONL12_19991	1.179e-49	202.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,1U9Z2@1239|Firmicutes,4HEVV@91061|Bacilli,1ZQT6@1386|Bacillus	91061|Bacilli	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1,Glycos_transf_2,Methyltransf_21
SX2_k127_3661143_0	757424.Hsero_4199	3.85e-101	342.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2VJDZ@28216|Betaproteobacteria,473V6@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
SX2_k127_3663203_2	1121091.AUMP01000001_gene81	1.89e-38	147.0	COG0233@1|root,COG0233@2|Bacteria,1V1F2@1239|Firmicutes,4HFSH@91061|Bacilli	91061|Bacilli	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
SX2_k127_3663203_0	1379698.RBG1_1C00001G1021	2.639e-94	316.0	COG0020@1|root,COG0020@2|Bacteria,2NP9M@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.31,2.5.1.68	ko:K00806,ko:K12503	ko00900,ko01110,map00900,map01110	-	R06447,R08528	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
SX2_k127_3663203_1	1379698.RBG1_1C00001G1022	3.307e-49	186.0	COG4589@1|root,COG4589@2|Bacteria,2NPVB@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
SX2_k127_3666945_1	1122138.AQUZ01000030_gene4687	1.647e-30	123.0	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria,4DPYP@85009|Propionibacteriales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX2_k127_3666945_0	1382356.JQMP01000003_gene1542	1.576e-64	232.0	COG0842@1|root,COG0842@2|Bacteria,2G9U5@200795|Chloroflexi,27Z6S@189775|Thermomicrobia	189775|Thermomicrobia	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
SX2_k127_3668316_0	518766.Rmar_1929	1.096e-31	141.0	COG3292@1|root,COG4257@1|root,COG3292@2|Bacteria,COG4257@2|Bacteria,4NDWE@976|Bacteroidetes	976|Bacteroidetes	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	Reg_prop
SX2_k127_3678324_1	671143.DAMO_2709	1.761e-36	142.0	COG1005@1|root,COG1005@2|Bacteria,2NQIK@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0045333,GO:0050136,GO:0055114	1.6.5.3	ko:K00337,ko:K05572	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
SX2_k127_3678324_0	671143.DAMO_2710	6.622e-132	431.0	COG0649@1|root,COG0649@2|Bacteria,2NNXB@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333,ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
SX2_k127_3678324_2	880073.Calab_2691	3.693e-26	111.0	COG0852@1|root,COG0852@2|Bacteria,2NPN6@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
SX2_k127_3689376_1	880073.Calab_2312	5.64e-36	149.0	COG5360@1|root,COG5360@2|Bacteria	2|Bacteria	S	Heparinase II/III-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Hepar_II_III,Hepar_II_III_N
SX2_k127_3689376_2	1131813.AQVT01000001_gene3138	4.733e-05	48.0	COG0438@1|root,COG0438@2|Bacteria,1R7YV@1224|Proteobacteria,2UGA4@28211|Alphaproteobacteria,1JRMD@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
SX2_k127_3689376_0	159087.Daro_2410	2.49e-38	148.0	COG0438@1|root,COG0438@2|Bacteria,1R2WM@1224|Proteobacteria,2VKPJ@28216|Betaproteobacteria,2KW40@206389|Rhodocyclales	206389|Rhodocyclales	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
SX2_k127_3698906_0	1379698.RBG1_1C00001G1865	3.19e-122	406.0	COG0557@1|root,COG0557@2|Bacteria,2NNV2@2323|unclassified Bacteria	2|Bacteria	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573,ko:K12585	ko03018,map03018	M00391	-	-	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
SX2_k127_3701265_0	1379698.RBG1_1C00001G0106	1.127e-83	288.0	COG0564@1|root,COG0564@2|Bacteria,2NNY5@2323|unclassified Bacteria	2|Bacteria	J	Responsible for synthesis of pseudouridine from uracil	rluD	GO:0000027,GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022607,GO:0022613,GO:0022618,GO:0031118,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360	5.4.99.23,5.4.99.28,5.4.99.29	ko:K06177,ko:K06180	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	iE2348C_1286.E2348C_2868,iECED1_1282.ECED1_3035,iECSF_1327.ECSF_2432	PseudoU_synth_2,S4
SX2_k127_3717275_1	1540257.JQMW01000011_gene1489	1.625e-12	69.0	COG1039@1|root,COG1039@2|Bacteria,1TQBE@1239|Firmicutes,24PH8@186801|Clostridia,36TQ4@31979|Clostridiaceae	186801|Clostridia	L	Ribonuclease HII	rnhC	-	3.1.26.4	ko:K03471	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DUF3378,RNase_HII
SX2_k127_3717275_0	1379698.RBG1_1C00001G1423	4.944e-16	92.0	COG2203@1|root,COG2203@2|Bacteria	2|Bacteria	T	Gaf domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GGDEF,HD,HD_5
SX2_k127_3720297_0	1379698.RBG1_1C00001G0503	4.304e-12	78.0	COG1807@1|root,COG1807@2|Bacteria,2NP0P@2323|unclassified Bacteria	2|Bacteria	M	Protein of unknown function (DUF2723)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723,PMT_2
SX2_k127_3720727_0	1379698.RBG1_1C00001G1225	3.81e-103	345.0	COG0539@1|root,COG0539@2|Bacteria,2NNTP@2323|unclassified Bacteria	2|Bacteria	J	Ribosomal protein S1	rpsA	GO:0005575,GO:0005576,GO:0018995,GO:0020003,GO:0030430,GO:0033643,GO:0033646,GO:0033655,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044421,GO:0065010	1.17.7.4,2.7.11.1	ko:K02945,ko:K03527,ko:K12132	ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010	M00096,M00178	R05884,R08210	RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko01001,ko03011	-	-	-	S1
SX2_k127_3720727_3	1123288.SOV_4c04400	1.047e-49	184.0	COG0204@1|root,COG0204@2|Bacteria,1U8N2@1239|Firmicutes,4H4EK@909932|Negativicutes	909932|Negativicutes	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
SX2_k127_3720727_1	574087.Acear_1032	1.473e-54	200.0	COG0283@1|root,COG0283@2|Bacteria,1V3IA@1239|Firmicutes,24HEF@186801|Clostridia,3WAMU@53433|Halanaerobiales	186801|Clostridia	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
SX2_k127_3720727_2	555088.DealDRAFT_0690	3.712e-50	183.0	COG1187@1|root,COG1187@2|Bacteria,1TP68@1239|Firmicutes,248UG@186801|Clostridia,42JUR@68298|Syntrophomonadaceae	186801|Clostridia	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.19,5.4.99.22	ko:K06178,ko:K06183	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
SX2_k127_3725524_0	1379698.RBG1_1C00001G0402	4.65e-186	600.0	COG1200@1|root,COG1200@2|Bacteria,2NNS3@2323|unclassified Bacteria	2|Bacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
SX2_k127_3728489_0	215803.DB30_5113	5.185e-96	328.0	COG0793@1|root,COG0793@2|Bacteria,1RGID@1224|Proteobacteria,4382G@68525|delta/epsilon subdivisions,2X3CI@28221|Deltaproteobacteria,2YVET@29|Myxococcales	28221|Deltaproteobacteria	M	tail specific protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
SX2_k127_3728489_1	944479.JQLX01000010_gene490	1.46e-18	93.0	COG1846@1|root,COG1846@2|Bacteria,1NDN2@1224|Proteobacteria,42WQ2@68525|delta/epsilon subdivisions,2WWZS@28221|Deltaproteobacteria,2M6QA@213113|Desulfurellales	28221|Deltaproteobacteria	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
SX2_k127_3728489_2	269799.Gmet_0667	0.0001609	47.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42N9V@68525|delta/epsilon subdivisions,2WJWQ@28221|Deltaproteobacteria,43UHW@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Ferritin-like domain	rbr	GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
SX2_k127_3733427_2	1379698.RBG1_1C00001G0473	2.792e-113	371.0	COG0549@1|root,COG0549@2|Bacteria,2NNKM@2323|unclassified Bacteria	2|Bacteria	E	Amino acid kinase family	arcC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_3652,iE2348C_1286.E2348C_0454,iECABU_c1320.ECABU_c31550,iECED1_1282.ECED1_0540,iECED1_1282.ECED1_3334,iECIAI39_1322.ECIAI39_3289,iECNA114_1301.ECNA114_2915,iECOK1_1307.ECOK1_3260,iECS88_1305.ECS88_3153,iECSF_1327.ECSF_2670,iECUMN_1333.ECUMN_0561,iEcE24377_1341.EcE24377A_0559,iG2583_1286.G2583_0641,iHN637.CLJU_RS13830,iJN746.PP_0999,iUMN146_1321.UM146_02150,iUTI89_1310.UTI89_C3259,ic_1306.c3452	AA_kinase
SX2_k127_3733427_1	927658.AJUM01000037_gene2274	5.317e-199	629.0	COG2403@1|root,COG2403@2|Bacteria,4NHIW@976|Bacteroidetes,2FNNX@200643|Bacteroidia	976|Bacteroidetes	S	cyclic 2,3-diphosphoglycerate synthetase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_3733427_0	1379698.RBG1_1C00001G0471	1.75e-216	678.0	COG1012@1|root,COG1012@2|Bacteria,2NNR8@2323|unclassified Bacteria	2|Bacteria	C	Belongs to the aldehyde dehydrogenase family	ycbD	-	1.2.1.3	ko:K00128,ko:K22187	ko00010,ko00040,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00040,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146,R11768	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
SX2_k127_3733615_1	1297742.A176_02652	7.039e-18	95.0	COG0726@1|root,COG0726@2|Bacteria,1MVKH@1224|Proteobacteria,42VRI@68525|delta/epsilon subdivisions,2WRUV@28221|Deltaproteobacteria,2YVYN@29|Myxococcales	28221|Deltaproteobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
SX2_k127_3733615_0	1158292.JPOE01000002_gene1571	4.333e-32	139.0	2E7PP@1|root,33259@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9
SX2_k127_3733615_2	211165.AJLN01000045_gene304	9.24e-05	48.0	2BJWR@1|root,32E95@2|Bacteria,1GHZC@1117|Cyanobacteria,1JIW1@1189|Stigonemataceae	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_3737175_0	684949.ATTJ01000001_gene843	3.042e-55	207.0	COG3303@1|root,COG3303@2|Bacteria	2|Bacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	1.7.2.2	ko:K03385	ko00910,ko01120,ko05132,map00910,map01120,map05132	M00530	R05712	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_C552,Cytochrome_C554,Paired_CXXCH_1
SX2_k127_373899_2	1201288.M900_1890	2.626e-20	92.0	COG0438@1|root,COG0438@2|Bacteria,1N9EV@1224|Proteobacteria,42PK2@68525|delta/epsilon subdivisions,2WN3F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
SX2_k127_373899_3	1267535.KB906767_gene2973	1.656e-18	90.0	2EFWM@1|root,339NX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_373899_1	1121396.KB893056_gene2649	1.298e-22	106.0	COG4232@1|root,COG4232@2|Bacteria,1R1X1@1224|Proteobacteria,42SD6@68525|delta/epsilon subdivisions,2WP2I@28221|Deltaproteobacteria,2MKNH@213118|Desulfobacterales	28221|Deltaproteobacteria	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_2
SX2_k127_373899_0	439235.Dalk_1881	1.921e-52	206.0	COG0457@1|root,COG1807@1|root,COG0457@2|Bacteria,COG1807@2|Bacteria,1R092@1224|Proteobacteria,43CRV@68525|delta/epsilon subdivisions,2X7ZG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
SX2_k127_3743945_0	880073.Calab_1151	1.284e-84	298.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
SX2_k127_3764143_1	1379698.RBG1_1C00001G0410	2.069e-44	164.0	COG0750@1|root,COG0750@2|Bacteria,2NP7C@2323|unclassified Bacteria	2|Bacteria	M	zinc metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
SX2_k127_3764143_0	1123371.ATXH01000001_gene1316	1.352e-118	393.0	COG0743@1|root,COG0743@2|Bacteria,2GHA5@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
SX2_k127_3764143_2	488538.SAR116_2176	9.384e-37	145.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2U591@28211|Alphaproteobacteria,4BQ68@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiA	-	5.2.1.8	ko:K01802,ko:K03767,ko:K03768,ko:K09565	ko01503,ko04020,ko04022,ko04217,ko05012,ko05016,ko05145,map01503,map04020,map04022,map04217,map05012,map05016,map05145	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
SX2_k127_3782314_0	1379698.RBG1_1C00001G1024	4.793e-50	190.0	COG0382@1|root,COG0382@2|Bacteria,2NRJ9@2323|unclassified Bacteria	2|Bacteria	H	UbiA prenyltransferase family	-	-	2.5.1.133,2.5.1.39,2.5.1.62	ko:K03179,ko:K04040	ko00130,ko00860,ko01100,ko01110,map00130,map00860,map01100,map01110	M00117	R05000,R05615,R06284,R09067,R11514,R11517	RC00020,RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
SX2_k127_3782314_1	324057.Pjdr2_0116	1.747e-25	112.0	COG0791@1|root,COG0791@2|Bacteria,1V9ZW@1239|Firmicutes,4HH84@91061|Bacilli,26SGY@186822|Paenibacillaceae	91061|Bacilli	M	Hydrolase	spr1	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60,SH3_3
SX2_k127_3795400_2	1379698.RBG1_1C00001G0088	5.796e-05	52.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	pal	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	CarboxypepD_reg,OmpA,PD40
SX2_k127_3795400_1	1239962.C943_03433	1.058e-27	124.0	COG3394@1|root,COG3394@2|Bacteria,4NFY5@976|Bacteroidetes,47MN2@768503|Cytophagia	976|Bacteroidetes	G	YdjC-like protein	-	-	3.5.1.105	ko:K03478	-	-	-	-	ko00000,ko01000	-	-	-	YdjC
SX2_k127_3795400_0	4432.XP_010265911.1	1.003e-125	411.0	COG0372@1|root,KOG2617@2759|Eukaryota,37JED@33090|Viridiplantae,3GF4T@35493|Streptophyta	35493|Streptophyta	C	Belongs to the citrate synthase family	-	GO:0000166,GO:0003674,GO:0003824,GO:0004108,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009060,GO:0009507,GO:0009536,GO:0009987,GO:0010035,GO:0010038,GO:0015980,GO:0016740,GO:0016746,GO:0016999,GO:0017076,GO:0017144,GO:0019752,GO:0030312,GO:0030554,GO:0031974,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036440,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045333,GO:0046686,GO:0046872,GO:0046912,GO:0046914,GO:0050896,GO:0055114,GO:0070013,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:0097367,GO:1901265,GO:1901363	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
SX2_k127_3799821_0	1162668.LFE_2206	7.159e-138	445.0	COG1085@1|root,COG1085@2|Bacteria,3J0ER@40117|Nitrospirae	40117|Nitrospirae	H	Galactose-1-phosphate uridyl transferase, N-terminal domain	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
SX2_k127_3799821_1	1519464.HY22_03430	7.083e-93	317.0	COG0297@1|root,COG0297@2|Bacteria,1FDT0@1090|Chlorobi	1090|Chlorobi	F	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
SX2_k127_380024_3	1379698.RBG1_1C00001G1377	1.047e-10	74.0	COG4409@1|root,COG4409@2|Bacteria,2NRD7@2323|unclassified Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	ASH,BNR_2,Big_3_2,CBM_35,DUF1080,F5_F8_type_C,PKD,RicinB_lectin_2,Trehalase
SX2_k127_380024_0	880073.Calab_1111	5.294e-113	392.0	COG0308@1|root,COG0308@2|Bacteria,2NPGQ@2323|unclassified Bacteria	2|Bacteria	E	aminopeptidase	pepN1	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
SX2_k127_380024_2	644282.Deba_1225	8.743e-18	99.0	COG2172@1|root,COG2204@1|root,COG2172@2|Bacteria,COG2204@2|Bacteria,1PGJ3@1224|Proteobacteria,4315J@68525|delta/epsilon subdivisions,2WWDE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase-like ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2,Response_reg
SX2_k127_380024_1	1125863.JAFN01000001_gene1021	8.382e-36	150.0	COG1639@1|root,COG1639@2|Bacteria,1RCW6@1224|Proteobacteria	1224|Proteobacteria	T	Signal transduction protein	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
SX2_k127_3803429_2	620914.JH621253_gene2672	0.0005	48.0	COG0110@1|root,COG2348@1|root,COG0110@2|Bacteria,COG2348@2|Bacteria,4NN92@976|Bacteroidetes,1I1VD@117743|Flavobacteriia,2YGX6@290174|Aquimarina	976|Bacteroidetes	V	Peptidogalycan biosysnthesis/recognition	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
SX2_k127_3803429_0	945713.IALB_3051	3.686e-63	244.0	COG4775@1|root,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2
SX2_k127_3803429_1	1120951.AUBG01000007_gene244	1.245e-05	54.0	2E7JD@1|root,3321K@2|Bacteria,4PM4I@976|Bacteroidetes,1IJJ8@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_3811180_1	580327.Tthe_2077	6.747e-52	193.0	COG0127@1|root,COG0127@2|Bacteria,1V6RN@1239|Firmicutes,249GK@186801|Clostridia,42G2V@68295|Thermoanaerobacterales	186801|Clostridia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
SX2_k127_3811180_0	941824.TCEL_00138	7.533e-69	239.0	COG0796@1|root,COG0796@2|Bacteria,1TPPR@1239|Firmicutes,249MB@186801|Clostridia,36DHC@31979|Clostridiaceae	186801|Clostridia	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
SX2_k127_3851153_3	880072.Desac_1503	1.886e-31	129.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria,2MQ8A@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
SX2_k127_3851153_2	1329516.JPST01000028_gene3359	1.236e-31	133.0	COG4221@1|root,COG4221@2|Bacteria,1V9C1@1239|Firmicutes,4ISDS@91061|Bacilli,27B2W@186824|Thermoactinomycetaceae	91061|Bacilli	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SX2_k127_3851153_0	644282.Deba_2229	2.071e-96	322.0	COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,42N4U@68525|delta/epsilon subdivisions,2WJR7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Converts GTP to 7,8-dihydroneopterin triphosphate	folE2	-	3.5.4.16	ko:K09007	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GCHY-1
SX2_k127_3851153_1	1131269.AQVV01000001_gene1293	1.009e-43	163.0	COG0720@1|root,COG0720@2|Bacteria	2|Bacteria	H	synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
SX2_k127_3851153_4	518766.Rmar_0834	5.958e-11	73.0	COG0558@1|root,COG0558@2|Bacteria,4NIC4@976|Bacteroidetes	976|Bacteroidetes	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
SX2_k127_3909308_0	797304.Natgr_3617	6.534e-66	235.0	COG0144@1|root,arCOG00973@2157|Archaea,2XUFZ@28890|Euryarchaeota,23SM5@183963|Halobacteria	183963|Halobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	cna	-	-	ko:K22446	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N
SX2_k127_3909308_1	1197130.BAFM01000001_gene103	1.94e-11	70.0	arCOG02286@1|root,arCOG02286@2157|Archaea,2XVQC@28890|Euryarchaeota,23V9K@183963|Halobacteria	183963|Halobacteria	S	Pfam:Nol1_Nop2_Fmu_2	-	-	-	-	-	-	-	-	-	-	-	-	Methyltranf_PUA
SX2_k127_3935967_1	880073.Calab_1952	4.73e-75	261.0	COG1774@1|root,COG1774@2|Bacteria,2NPEB@2323|unclassified Bacteria	2|Bacteria	S	PSP1 C-terminal conserved region	yaaT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	PSP1
SX2_k127_3935967_0	517418.Ctha_0112	7.336e-92	324.0	COG1629@1|root,COG4771@2|Bacteria,1FEX4@1090|Chlorobi	1090|Chlorobi	P	CarboxypepD_reg-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug
SX2_k127_3943829_0	1379698.RBG1_1C00001G0150	1.61e-187	591.0	COG0056@1|root,COG0056@2|Bacteria,2NP0S@2323|unclassified Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	iIT341.HP1134,iSB619.SA_RS10975,iSbBS512_1146.SbBS512_E4187	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
SX2_k127_3943829_1	1379698.RBG1_1C00001G0152	6.782e-58	209.0	COG0224@1|root,COG0224@2|Bacteria,2NP76@2323|unclassified Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iLJ478.TM1611,iSSON_1240.SSON_3886,iYL1228.KPN_04138	ATP-synt
SX2_k127_3976828_0	1379698.RBG1_1C00001G0414	9.95e-200	629.0	COG0525@1|root,COG0525@2|Bacteria,2NNKR@2323|unclassified Bacteria	2|Bacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iLJ478.TM1817	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
SX2_k127_3979002_6	1501230.ET33_03905	3.128e-11	64.0	COG0394@1|root,COG0394@2|Bacteria,1VA05@1239|Firmicutes,4HKBQ@91061|Bacilli,26QZ1@186822|Paenibacillaceae	91061|Bacilli	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	ywlE	-	3.1.3.48,3.9.1.2	ko:K01104,ko:K20201	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
SX2_k127_3979002_5	1123371.ATXH01000005_gene2137	4.862e-26	117.0	COG0009@1|root,COG0009@2|Bacteria,2GGWC@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Telomere recombination	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
SX2_k127_3979002_0	1379698.RBG1_1C00001G1252	6.516e-127	416.0	COG0836@1|root,COG0836@2|Bacteria,2NP3C@2323|unclassified Bacteria	2|Bacteria	M	Mannose-6-phosphate isomerase	manC	-	2.7.7.13,5.3.1.8,5.4.2.8	ko:K00971,ko:K01840,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01818,R01819	RC00002,RC00376,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS00940	MannoseP_isomer,NTP_transferase
SX2_k127_3979002_4	1242864.D187_001881	3.265e-26	117.0	COG1216@1|root,COG1216@2|Bacteria,1QUP1@1224|Proteobacteria	1224|Proteobacteria	S	COG0463 Glycosyltransferases involved in cell wall biogenesis	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
SX2_k127_3979002_2	1267534.KB906755_gene4123	1.698e-57	206.0	COG0110@1|root,COG0110@2|Bacteria	2|Bacteria	S	O-acyltransferase activity	wbpD	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
SX2_k127_3979002_1	1519464.HY22_10225	4.31e-115	381.0	COG0673@1|root,COG0673@2|Bacteria,1FEZX@1090|Chlorobi	1090|Chlorobi	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
SX2_k127_3979002_3	880073.Calab_2081	2.545e-27	117.0	COG3291@1|root,COG5276@1|root,COG3291@2|Bacteria,COG5276@2|Bacteria,2NQ2P@2323|unclassified Bacteria	2|Bacteria	P	LVIVD repeat	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	LVIVD
SX2_k127_4028329_0	1379698.RBG1_1C00001G1258	1.117e-98	325.0	COG4972@1|root,COG4972@2|Bacteria,2NPF6@2323|unclassified Bacteria	2|Bacteria	NU	Type IV pilus assembly protein PilM;	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
SX2_k127_4028329_2	1379698.RBG1_1C00001G1257	2.125e-43	171.0	COG3166@1|root,COG3166@2|Bacteria	2|Bacteria	NU	PFAM Fimbrial assembly family protein	pilN	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
SX2_k127_4028329_1	1379698.RBG1_1C00001G1256	1.94e-43	163.0	COG3167@1|root,COG3167@2|Bacteria,2NPUF@2323|unclassified Bacteria	2|Bacteria	NU	Pilus assembly protein, PilO	pilO	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
SX2_k127_4028959_0	706587.Desti_3500	1.658e-27	113.0	2DN5R@1|root,32VPU@2|Bacteria,1N0SE@1224|Proteobacteria	1224|Proteobacteria	S	Putative zinc ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Zn_ribbon_2
SX2_k127_4028959_1	158190.SpiGrapes_1961	1.33e-21	100.0	28PJ3@1|root,2ZC8W@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4031021_0	370438.PTH_2112	4.107e-34	137.0	COG1256@1|root,COG1749@1|root,COG1256@2|Bacteria,COG1749@2|Bacteria,1TPXH@1239|Firmicutes,249PE@186801|Clostridia,260KA@186807|Peptococcaceae	186801|Clostridia	N	TIGRFAM Flagellar hook-associated protein, FlgK	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
SX2_k127_4031021_1	1379698.RBG1_1C00001G1112	9.233e-19	89.0	COG1551@1|root,COG1551@2|Bacteria,2NQ31@2323|unclassified Bacteria	2|Bacteria	J	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding	csrA	-	-	ko:K03563,ko:K13626	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko02035,ko03019	-	-	-	CsrA
SX2_k127_4031021_2	1033739.CAEU01000006_gene1288	6.816e-18	88.0	COG1344@1|root,COG1344@2|Bacteria,1TPDT@1239|Firmicutes,4HCCZ@91061|Bacilli,26DFI@186818|Planococcaceae	91061|Bacilli	N	Belongs to the bacterial flagellin family	flgL	GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464	-	ko:K02397	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
SX2_k127_4032861_0	1519464.HY22_03120	9.266e-68	235.0	COG1335@1|root,COG1335@2|Bacteria,1FE0F@1090|Chlorobi	1090|Chlorobi	Q	PFAM isochorismatase hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
SX2_k127_4032861_1	880073.Calab_0900	1.839e-49	183.0	COG2078@1|root,COG2078@2|Bacteria,2NPQ0@2323|unclassified Bacteria	2|Bacteria	S	AMMECR1	-	-	-	ko:K06990,ko:K09141	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,Memo
SX2_k127_403472_2	867845.KI911784_gene2719	4.026e-58	212.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PKD,SBBP
SX2_k127_403472_5	867845.KI911784_gene2719	2.202e-24	111.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PKD,SBBP
SX2_k127_403472_4	1408423.JHYA01000013_gene163	5.226e-26	113.0	COG1576@1|root,COG1576@2|Bacteria,1V3JM@1239|Firmicutes,4H41M@909932|Negativicutes	909932|Negativicutes	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
SX2_k127_403472_3	484019.THA_724	5.492e-51	184.0	COG0432@1|root,COG0432@2|Bacteria,2GD2P@200918|Thermotogae	200918|Thermotogae	S	PFAM Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
SX2_k127_403472_1	913865.DOT_3500	2.897e-93	315.0	COG0552@1|root,COG0552@2|Bacteria,1TPRI@1239|Firmicutes,247JD@186801|Clostridia,260N3@186807|Peptococcaceae	186801|Clostridia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
SX2_k127_403472_0	1379698.RBG1_1C00001G1432	4.141e-108	382.0	COG1196@1|root,COG1196@2|Bacteria,2NNYZ@2323|unclassified Bacteria	2|Bacteria	D	Required for chromosome condensation and partitioning	smc	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03529,ko:K19171	-	-	-	-	ko00000,ko02048,ko03036	-	-	-	SMC_N,SMC_hinge
SX2_k127_4051999_0	1033737.CAEV01000017_gene3208	7.596e-18	94.0	COG0438@1|root,COG0438@2|Bacteria,1TSNT@1239|Firmicutes,248MH@186801|Clostridia,36EEX@31979|Clostridiaceae	186801|Clostridia	M	Group 1 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_2,Glyco_transf_4,Glycos_transf_1
SX2_k127_4052736_1	1379698.RBG1_1C00001G1151	9.376e-28	116.0	COG0779@1|root,COG0779@2|Bacteria,2NPVA@2323|unclassified Bacteria	2|Bacteria	S	Required for maturation of 30S ribosomal subunits	rimP	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
SX2_k127_4052736_0	1379698.RBG1_1C00001G1152	2.068e-68	237.0	COG0195@1|root,COG0195@2|Bacteria,2NNV1@2323|unclassified Bacteria	2|Bacteria	K	Participates in both transcription termination and antitermination	nusA	GO:0001000,GO:0001121,GO:0001125,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
SX2_k127_4056681_1	1380391.JIAS01000005_gene2454	3.835e-34	136.0	28I8X@1|root,2Z8BQ@2|Bacteria,1MW9X@1224|Proteobacteria,2TVGJ@28211|Alphaproteobacteria,2JPR0@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4056681_2	1121451.DESAM_22835	4.059e-26	115.0	2DZ82@1|root,32V6V@2|Bacteria,1N3UK@1224|Proteobacteria,431CX@68525|delta/epsilon subdivisions,2WX13@28221|Deltaproteobacteria,2M9YP@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Tube
SX2_k127_4056681_0	1380391.JIAS01000005_gene2450	7.553e-67	238.0	2AG7K@1|root,316CP@2|Bacteria,1Q5UJ@1224|Proteobacteria,2VC4W@28211|Alphaproteobacteria,2JXW8@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4071610_0	1321778.HMPREF1982_04683	2.049e-54	205.0	COG0466@1|root,COG0466@2|Bacteria,1TNYG@1239|Firmicutes,247SH@186801|Clostridia,268F6@186813|unclassified Clostridiales	186801|Clostridia	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
SX2_k127_4071610_1	456442.Mboo_2458	0.0002498	53.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,2N9A8@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
SX2_k127_4095826_0	1192034.CAP_8674	2.988e-197	627.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,42PMM@68525|delta/epsilon subdivisions,2WWD4@28221|Deltaproteobacteria,2YTYG@29|Myxococcales	28221|Deltaproteobacteria	S	oligopeptide transporter, OPT family	-	-	-	-	-	-	-	-	-	-	-	-	OPT
SX2_k127_4107028_1	243231.GSU0856	1.163e-90	302.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,42MEE@68525|delta/epsilon subdivisions,2WJYV@28221|Deltaproteobacteria,43T22@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
SX2_k127_4107028_0	98439.AJLL01000010_gene1388	4.996e-241	761.0	COG1770@1|root,COG1770@2|Bacteria,1G1RH@1117|Cyanobacteria,1JHGU@1189|Stigonemataceae	1117|Cyanobacteria	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
SX2_k127_4114978_0	398767.Glov_0676	2.7e-79	281.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,42M1T@68525|delta/epsilon subdivisions,2WK0W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Penicillin-binding protein, dimerisation domain	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
SX2_k127_4114978_1	338963.Pcar_2210	1.182e-66	240.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,42N5Q@68525|delta/epsilon subdivisions,2WJ8J@28221|Deltaproteobacteria,43SBK@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	MraW methylase family	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
SX2_k127_4114978_2	273068.TTE1654	1.804e-26	113.0	COG2001@1|root,COG2001@2|Bacteria,1V3JD@1239|Firmicutes,24HB9@186801|Clostridia,42GA2@68295|Thermoanaerobacterales	186801|Clostridia	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
SX2_k127_4122603_1	1449126.JQKL01000021_gene57	1.458e-82	282.0	COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,248D0@186801|Clostridia	186801|Clostridia	G	M42 glutamyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
SX2_k127_4122603_0	1379698.RBG1_1C00001G0842	1.07e-85	293.0	COG1181@1|root,COG1181@2|Bacteria,2NPB2@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
SX2_k127_4134946_0	215803.DB30_3531	4.417e-55	212.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42NYP@68525|delta/epsilon subdivisions,2WIPJ@28221|Deltaproteobacteria,2YXKT@29|Myxococcales	28221|Deltaproteobacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
SX2_k127_4140450_3	880073.Calab_3413	0.0003772	48.0	COG2304@1|root,COG2304@2|Bacteria,2NPZ4@2323|unclassified Bacteria	2|Bacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M64,Phage-tail_3,VWA
SX2_k127_4140450_0	1379698.RBG1_1C00001G1639	5.436e-87	299.0	COG0142@1|root,COG0142@2|Bacteria,2NP7G@2323|unclassified Bacteria	2|Bacteria	H	Belongs to the FPP GGPP synthase family	ispB	GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663	2.5.1.30,2.5.1.90	ko:K00805,ko:K02523	ko00900,ko01110,map00900,map01110	-	R09247,R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	iYL1228.KPN_03597,ic_1306.c3945	polyprenyl_synt
SX2_k127_4140450_2	1379698.RBG1_1C00001G1399	3.621e-13	82.0	COG4447@1|root,COG4447@2|Bacteria,2NRC1@2323|unclassified Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,PSII_BNR
SX2_k127_4140797_2	1122609.AUGT01000021_gene1184	1.133e-10	63.0	COG1595@1|root,COG1595@2|Bacteria,2GJ02@201174|Actinobacteria,4DMYC@85009|Propionibacteriales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigH	GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SX2_k127_4140797_1	1121920.AUAU01000017_gene1243	1.162e-11	75.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4,MucBP
SX2_k127_4140797_0	1379698.RBG1_1C00001G1223	1.474e-62	220.0	COG0665@1|root,COG0665@2|Bacteria,2NP0X@2323|unclassified Bacteria	2|Bacteria	E	FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
SX2_k127_41470_2	290317.Cpha266_0303	7.453e-76	261.0	COG0586@1|root,COG0586@2|Bacteria,1FE4G@1090|Chlorobi	1090|Chlorobi	S	PFAM SNARE associated Golgi protein	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
SX2_k127_41470_3	671143.DAMO_2629	3.908e-69	243.0	COG0767@1|root,COG0767@2|Bacteria,2NPFZ@2323|unclassified Bacteria	2|Bacteria	Q	ABC-type transport system involved in resistance to organic solvents permease component	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
SX2_k127_41470_1	1379698.RBG1_1C00001G0979	4.602e-80	273.0	COG1127@1|root,COG1127@2|Bacteria,2NP3U@2323|unclassified Bacteria	2|Bacteria	Q	ABC-type transport system involved in resistance to organic solvents, ATPase component	mkl	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
SX2_k127_41470_4	269799.Gmet_2541	8.064e-32	137.0	COG1463@1|root,COG1463@2|Bacteria,1MY8D@1224|Proteobacteria,42TCA@68525|delta/epsilon subdivisions,2WP6I@28221|Deltaproteobacteria,43TRY@69541|Desulfuromonadales	28221|Deltaproteobacteria	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
SX2_k127_41470_0	573061.Clocel_2976	3.973e-83	283.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,36EDS@31979|Clostridiaceae	186801|Clostridia	I	Belongs to the enoyl-CoA hydratase isomerase family	crt	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
SX2_k127_41470_5	448385.sce3387	3.028e-15	82.0	COG4447@1|root,COG4447@2|Bacteria,1R42J@1224|Proteobacteria,42WGC@68525|delta/epsilon subdivisions,2WRHI@28221|Deltaproteobacteria,2YVIP@29|Myxococcales	28221|Deltaproteobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4150995_1	379066.GAU_3597	7.427e-17	81.0	COG4877@1|root,COG4877@2|Bacteria,1ZVAE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4150995_0	1340493.JNIF01000003_gene4176	5.34e-82	276.0	COG0330@1|root,COG0330@2|Bacteria,3Y7B6@57723|Acidobacteria	57723|Acidobacteria	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
SX2_k127_4178957_1	880073.Calab_0506	2.211e-19	94.0	COG0845@1|root,COG0845@2|Bacteria,2NQN5@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3,HlyD_D23
SX2_k127_4178957_0	1047013.AQSP01000138_gene1077	1.851e-59	223.0	COG1538@1|root,COG1538@2|Bacteria,2NPKK@2323|unclassified Bacteria	2|Bacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
SX2_k127_4178957_2	335541.Swol_0177	6.959e-17	88.0	COG1309@1|root,COG1309@2|Bacteria,1VEA5@1239|Firmicutes,24N99@186801|Clostridia,42K7C@68298|Syntrophomonadaceae	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
SX2_k127_4185240_0	1379698.RBG1_1C00001G1066	6.59e-119	399.0	COG0260@1|root,COG0260@2|Bacteria,2NNKH@2323|unclassified Bacteria	2|Bacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	GO:0001073,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006351,GO:0006355,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009056,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016787,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042150,GO:0043170,GO:0043171,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043244,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0097718,GO:0140096,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1903506,GO:2000112,GO:2001141	3.4.11.1,3.4.11.5	ko:K01255,ko:K01259	ko00330,ko00480,ko01100,map00330,map00480,map01100	-	R00135,R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
SX2_k127_4185240_1	330214.NIDE3360	2.007e-13	80.0	COG0823@1|root,COG0823@2|Bacteria,3J0U9@40117|Nitrospirae	40117|Nitrospirae	U	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
SX2_k127_4196427_1	565033.GACE_0862	1.077e-56	214.0	COG5410@1|root,arCOG09550@2157|Archaea,2XW1V@28890|Euryarchaeota,246R7@183980|Archaeoglobi	183980|Archaeoglobi	S	Terminase RNaseH-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6,Terminase_6C
SX2_k127_4201253_0	378806.STAUR_2875	5.06e-09	63.0	COG5297@1|root,COG5297@2|Bacteria,1QZI4@1224|Proteobacteria,43CJ7@68525|delta/epsilon subdivisions,2X7TJ@28221|Deltaproteobacteria,2YXMV@29|Myxococcales	28221|Deltaproteobacteria	G	Glycosyl hydrolases family 6	-	-	3.2.1.91	ko:K19668	ko00500,ko01100,ko02020,map00500,map01100,map02020	-	R02886,R11308	RC00799	ko00000,ko00001,ko01000	-	GH6	-	CBM_3,Glyco_hydro_6,fn3
SX2_k127_4203695_1	1499967.BAYZ01000178_gene4656	6.92e-80	274.0	COG0758@1|root,COG0758@2|Bacteria,2NP2V@2323|unclassified Bacteria	2|Bacteria	LU	DNA recombination-mediator protein A	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
SX2_k127_4203695_3	555079.Toce_0866	1.015e-21	96.0	COG1925@1|root,COG1925@2|Bacteria,1VA0R@1239|Firmicutes,24QIP@186801|Clostridia,42HAI@68295|Thermoanaerobacterales	186801|Clostridia	G	PTS HPr component phosphorylation site	ptsH	-	-	ko:K11184,ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
SX2_k127_4203695_0	555079.Toce_1427	2.003e-136	454.0	COG1080@1|root,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,248QP@186801|Clostridia,42FHW@68295|Thermoanaerobacterales	186801|Clostridia	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsP	-	2.7.3.9,2.7.9.2	ko:K01007,ko:K08483	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00720,map01100,map01120,map01200,map02060	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
SX2_k127_4203695_2	632518.Calow_0495	8.172e-58	209.0	COG2222@1|root,COG2222@2|Bacteria,1TRBS@1239|Firmicutes,24A9W@186801|Clostridia,42EVQ@68295|Thermoanaerobacterales	186801|Clostridia	G	TIGRFAM bifunctional phosphoglucose phosphomannose isomerase	-	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS,bact-PGI_C
SX2_k127_4207626_1	1047013.AQSP01000093_gene14	7.397e-45	166.0	COG2920@1|root,COG2920@2|Bacteria,2NQ6I@2323|unclassified Bacteria	2|Bacteria	P	DsrC like protein	dsrC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
SX2_k127_4207626_2	1047013.AQSP01000093_gene13	9.751e-40	155.0	COG2181@1|root,COG2181@2|Bacteria	2|Bacteria	C	nitrate reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	SLAC1
SX2_k127_4207626_0	1047013.AQSP01000077_gene2274	1.569e-184	586.0	COG0247@1|root,COG0247@2|Bacteria	2|Bacteria	C	lactate metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17,Fer4_8,Fer4_9
SX2_k127_4210093_0	1379698.RBG1_1C00001G0723	6.636e-81	288.0	COG0860@1|root,COG0860@2|Bacteria,2NPCZ@2323|unclassified Bacteria	2|Bacteria	M	Ami_3	amiA	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
SX2_k127_4210093_1	1121468.AUBR01000008_gene2068	2.469e-54	194.0	COG0691@1|root,COG0691@2|Bacteria,1V3IJ@1239|Firmicutes,24HD6@186801|Clostridia,42GC6@68295|Thermoanaerobacterales	186801|Clostridia	J	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
SX2_k127_4210093_2	861299.J421_4362	2.812e-11	64.0	COG0589@1|root,COG0589@2|Bacteria,1ZTUZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
SX2_k127_4226440_2	767434.Fraau_0833	9.135e-40	166.0	COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,1X3ZE@135614|Xanthomonadales	135614|Xanthomonadales	KL	Helicase	yoaA	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2,ResIII
SX2_k127_4226440_1	1047013.AQSP01000140_gene2448	1.202e-74	262.0	COG0372@1|root,COG0372@2|Bacteria	2|Bacteria	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1,4.1.3.34	ko:K01647,ko:K15234	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R00351,R00354	RC00004,RC00067,RC00502	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
SX2_k127_4226440_0	1191523.MROS_2692	7.727e-94	317.0	COG0058@1|root,COG0058@2|Bacteria	2|Bacteria	G	glycogen phosphorylase activity	malP	-	2.4.1.1,2.4.1.8	ko:K00688,ko:K00691	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R01555,R02111	RC00049	ko00000,ko00001,ko01000	-	GH65,GT35	-	DUF3417,Phosphorylase
SX2_k127_4248009_2	1191523.MROS_0483	1.909e-31	124.0	COG1538@1|root,COG1538@2|Bacteria	2|Bacteria	MU	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	OEP
SX2_k127_4248009_1	1191523.MROS_0482	1.701e-87	302.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
SX2_k127_4248009_0	1191523.MROS_0481	7.841e-145	467.0	COG0841@1|root,COG0841@2|Bacteria	2|Bacteria	V	transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
SX2_k127_4261963_1	880073.Calab_3487	7.357e-23	106.0	COG1729@1|root,COG1729@2|Bacteria	2|Bacteria	S	protein trimerization	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_21,TPR_6
SX2_k127_4261963_0	1123376.AUIU01000014_gene636	1.509e-140	462.0	COG1449@1|root,COG1449@2|Bacteria,3J0AQ@40117|Nitrospirae	40117|Nitrospirae	G	Glycosyl hydrolase family 57	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
SX2_k127_4263430_3	1395513.P343_00530	7.282e-16	83.0	COG0454@1|root,COG0456@2|Bacteria,1V4GU@1239|Firmicutes,4HKA1@91061|Bacilli	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SX2_k127_4263430_1	644282.Deba_0338	3.737e-64	233.0	COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,42MRS@68525|delta/epsilon subdivisions,2WJW8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
SX2_k127_4263430_2	1121422.AUMW01000013_gene1444	3.412e-47	176.0	COG0461@1|root,COG0461@2|Bacteria,1V1BZ@1239|Firmicutes,24AS1@186801|Clostridia	186801|Clostridia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
SX2_k127_4263430_0	1379698.RBG1_1C00001G0215	9.573e-115	385.0	COG0577@1|root,COG0577@2|Bacteria,2NP20@2323|unclassified Bacteria	2|Bacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX2_k127_4270814_1	643648.Slip_0863	8.044e-06	52.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1TP3N@1239|Firmicutes,248CS@186801|Clostridia,42JNV@68298|Syntrophomonadaceae	186801|Clostridia	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	sun	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
SX2_k127_4270814_0	1379698.RBG1_1C00001G0940	8.69e-74	266.0	COG1032@1|root,COG5011@1|root,COG1032@2|Bacteria,COG5011@2|Bacteria,2NNKI@2323|unclassified Bacteria	2|Bacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344,Radical_SAM
SX2_k127_42709_1	1047013.AQSP01000114_gene698	5.139e-43	166.0	2CK1R@1|root,31E53@2|Bacteria,2NR8M@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_42709_0	471854.Dfer_1961	1.059e-51	192.0	COG4122@1|root,COG4122@2|Bacteria,4NPJQ@976|Bacteroidetes,47WE2@768503|Cytophagia	976|Bacteroidetes	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
SX2_k127_42709_2	1047013.AQSP01000109_gene2435	6.745e-18	89.0	COG0253@1|root,COG0253@2|Bacteria,2NPFA@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	iIT341.HP0566,iLJ478.TM1522	DAP_epimerase
SX2_k127_427586_0	1379698.RBG1_1C00001G1150	2.499e-133	430.0	COG0442@1|root,COG0442@2|Bacteria,2NNNH@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0043906,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iJN678.proS,iUTI89_1310.UTI89_C0210	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
SX2_k127_4281313_1	1379698.RBG1_1C00001G1785	1.286e-39	156.0	2EAWV@1|root,334Y2@2|Bacteria,2NRSF@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4281313_0	1379698.RBG1_1C00001G1786	3.397e-42	168.0	2CUTJ@1|root,32SW3@2|Bacteria,2NRD1@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4281313_2	1379698.RBG1_1C00001G1787	2.029e-36	152.0	COG1520@1|root,COG4412@1|root,COG1520@2|Bacteria,COG4412@2|Bacteria,2NPRE@2323|unclassified Bacteria	2|Bacteria	S	Evidence 5 No homology to any previously reported sequences	-	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	DUF1863,PQQ_2
SX2_k127_4293204_3	1379698.RBG1_1C00001G0361	1.723e-39	149.0	COG0530@1|root,COG0530@2|Bacteria,2NPSH@2323|unclassified Bacteria	2|Bacteria	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
SX2_k127_4293204_5	1121324.CLIT_13c01430	1.623e-09	69.0	COG0517@1|root,COG0517@2|Bacteria,1VA1X@1239|Firmicutes,24MNT@186801|Clostridia	186801|Clostridia	EGP	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SX2_k127_4293204_4	572544.Ilyop_1366	4.066e-16	89.0	COG1762@1|root,COG1762@2|Bacteria,379WR@32066|Fusobacteria	32066|Fusobacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2	-	-	2.7.1.202	ko:K02768,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2
SX2_k127_4293204_2	1379698.RBG1_1C00001G0360	2.586e-51	188.0	COG2928@1|root,COG2928@2|Bacteria,2NR55@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
SX2_k127_4293204_0	1121468.AUBR01000050_gene2028	3.66e-108	367.0	COG1007@1|root,COG1007@2|Bacteria,1TR55@1239|Firmicutes,25ED8@186801|Clostridia,42FCA@68295|Thermoanaerobacterales	186801|Clostridia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
SX2_k127_4293204_1	880073.Calab_2684	1.797e-97	326.0	COG1008@1|root,COG1008@2|Bacteria,2NNQ9@2323|unclassified Bacteria	2|Bacteria	C	NADH-quinone oxidoreductase, chain M	nuoM2	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
SX2_k127_4301315_2	518766.Rmar_2589	4.03e-81	273.0	COG1941@1|root,COG1941@2|Bacteria	2|Bacteria	C	coenzyme F420 hydrogenase activity	hoxY	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
SX2_k127_4301315_0	247490.KSU1_A0075	2.162e-118	387.0	COG0543@1|root,COG0543@2|Bacteria,2IYBB@203682|Planctomycetes	203682|Planctomycetes	C	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
SX2_k127_4301315_3	1299327.I546_7001	1.906e-57	203.0	COG0664@1|root,COG0664@2|Bacteria,2IRJW@201174|Actinobacteria	201174|Actinobacteria	T	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
SX2_k127_4301315_1	272134.KB731324_gene5860	1.934e-85	287.0	COG1453@1|root,COG1453@2|Bacteria	2|Bacteria	S	Aldo/keto reductase family	asrA	-	-	ko:K16950	ko00920,ko01120,map00920,map01120	-	R00858,R10146	RC00065	ko00000,ko00001	-	-	-	Aldo_ket_red,Fer4_22
SX2_k127_4313471_0	1120971.AUCA01000021_gene1064	1.343e-83	284.0	COG2220@1|root,COG2220@2|Bacteria,1TQR1@1239|Firmicutes,4HBM0@91061|Bacilli,2796V@186823|Alicyclobacillaceae	91061|Bacilli	S	Belongs to the UPF0173 family	bCE_4747	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Lactamase_B_3
SX2_k127_4313471_1	1189620.AJXL01000088_gene4	1.591e-05	57.0	COG2982@1|root,COG2982@2|Bacteria,4NEJQ@976|Bacteroidetes,1HXHN@117743|Flavobacteriia,2NU9B@237|Flavobacterium	976|Bacteroidetes	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	AsmA,AsmA_2
SX2_k127_4316415_0	1379698.RBG1_1C00001G0122	5.192e-222	693.0	COG1070@1|root,COG1070@2|Bacteria,2NP2A@2323|unclassified Bacteria	2|Bacteria	G	MutL protein	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N,MutL
SX2_k127_4324269_1	1379698.RBG1_1C00001G1075	1.281e-72	254.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3,HlyD_D23
SX2_k127_4324269_0	1379698.RBG1_1C00001G1076	2.262e-277	864.0	COG3696@1|root,COG3696@2|Bacteria,2NP07@2323|unclassified Bacteria	2|Bacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
SX2_k127_4335669_1	983920.Y88_3095	2.81e-15	88.0	2DEQP@1|root,2ZNVI@2|Bacteria,1QXJ3@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4335669_0	1379698.RBG1_1C00001G0533	7.799e-89	300.0	COG0454@1|root,COG0456@2|Bacteria,2NNUP@2323|unclassified Bacteria	2|Bacteria	K	acetyltransferase	yghO	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SX2_k127_4339734_0	525903.Taci_0090	3.807e-19	94.0	COG0745@1|root,COG0745@2|Bacteria,3TAJR@508458|Synergistetes	508458|Synergistetes	K	PFAM response regulator receiver	-	-	-	ko:K07657,ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SX2_k127_4342156_0	1047013.AQSP01000134_gene1338	4.77e-129	429.0	COG5598@1|root,COG5598@2|Bacteria,2NQTC@2323|unclassified Bacteria	2|Bacteria	H	Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
SX2_k127_4374972_0	1125863.JAFN01000001_gene217	8.22e-42	168.0	COG1345@1|root,COG1345@2|Bacteria,1MUVP@1224|Proteobacteria,42MHW@68525|delta/epsilon subdivisions,2WNU5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	N	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end	fliD	-	-	ko:K02407	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_IN,FliD_C,FliD_N
SX2_k127_4374972_1	290398.Csal_2033	4.285e-10	65.0	COG1345@1|root,COG1345@2|Bacteria,1MUVP@1224|Proteobacteria,1RS2S@1236|Gammaproteobacteria,1XKCN@135619|Oceanospirillales	135619|Oceanospirillales	N	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end	-	-	-	ko:K02407	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_IN,FliD_C,FliD_N
SX2_k127_439191_0	251221.35211292	1.817e-144	479.0	COG5549@1|root,COG5549@2|Bacteria,1G2AK@1117|Cyanobacteria	1117|Cyanobacteria	O	Domain of unknown function (DUF5117)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4953,DUF5117,DUF5118
SX2_k127_4415115_3	1408418.JNJH01000022_gene1802	0.0002151	48.0	2BJAV@1|root,32DKS@2|Bacteria,1P2JW@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4454703_0	1379698.RBG1_1C00001G0649	4.163e-60	217.0	COG2045@1|root,COG2045@2|Bacteria,2NPF1@2323|unclassified Bacteria	2|Bacteria	H	Belongs to the ComB family	comB	GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0050545	3.1.3.71	ko:K05979	ko00680,ko01120,map00680,map01120	M00358	R05789	RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	2-ph_phosp
SX2_k127_4454703_1	880073.Calab_3536	1.777e-50	183.0	COG0404@1|root,COG0404@2|Bacteria,2NNSR@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
SX2_k127_4496449_1	864051.BurJ1DRAFT_4160	0.0005611	51.0	COG3391@1|root,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,2WF5Y@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4496449_0	682795.AciX8_2124	6.734e-80	279.0	COG0312@1|root,COG0312@2|Bacteria,3Y3MT@57723|Acidobacteria,2JKR9@204432|Acidobacteriia	57723|Acidobacteria	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
SX2_k127_4516063_0	1379698.RBG1_1C00001G1115	2.191e-159	512.0	COG0441@1|root,COG0441@2|Bacteria,2NNMT@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
SX2_k127_4516063_2	1121939.L861_02510	1.263e-29	129.0	2FADW@1|root,342N8@2|Bacteria,1NYAF@1224|Proteobacteria,1SQ2Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4516063_1	452652.KSE_16470	1.633e-33	136.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria,2M4SG@2063|Kitasatospora	201174|Actinobacteria	E	DegT DnrJ EryC1 StrS aminotransferase family	eryCIV	GO:0005575,GO:0005576,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009607,GO:0009987,GO:0009991,GO:0010106,GO:0019725,GO:0030003,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042592,GO:0042594,GO:0043207,GO:0044403,GO:0044419,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071496,GO:0075136,GO:0098771	2.6.1.33	ko:K13308	ko00523,ko01130,map00523,map01130	M00797	R02773	RC00006,RC00781	ko00000,ko00001,ko00002,ko01000	-	-	-	DegT_DnrJ_EryC1
SX2_k127_4518754_0	1379698.RBG1_1C00001G0991	3.403e-85	310.0	COG2911@1|root,COG2931@1|root,COG4447@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG4447@2|Bacteria,2NR5X@2323|unclassified Bacteria	2|Bacteria	Q	FlgD Ig-like domain	-	-	3.2.1.136	ko:K15924	-	-	-	-	ko00000,ko01000	-	GH5	-	CBM_3,DUF1735,Laminin_G_3
SX2_k127_4521073_0	1379698.RBG1_1C00001G0682	0.0002699	44.0	COG2755@1|root,COG2755@2|Bacteria,2NR42@2323|unclassified Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	ko:K20306	-	-	-	-	ko00000,ko04131	-	-	-	Lipase_GDSL,Lipase_GDSL_2
SX2_k127_4522496_1	1047013.AQSP01000093_gene11	3.689e-43	160.0	COG0520@1|root,COG0520@2|Bacteria,2NNS0@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
SX2_k127_4522496_0	251221.35211369	1.626e-73	259.0	COG1879@1|root,COG1879@2|Bacteria,1G06J@1117|Cyanobacteria	1117|Cyanobacteria	G	PFAM periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
SX2_k127_4522496_2	521045.Kole_0604	3.748e-24	104.0	COG1129@1|root,COG1129@2|Bacteria,2GC9C@200918|Thermotogae	200918|Thermotogae	P	PFAM ABC transporter	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
SX2_k127_4526842_0	688269.Theth_0595	2.141e-39	156.0	COG2208@1|root,COG2208@2|Bacteria,2GDGV@200918|Thermotogae	200918|Thermotogae	T	Stage II sporulation	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Response_reg,SpoIIE
SX2_k127_4526842_2	1191523.MROS_2851	1.609e-11	71.0	COG2172@1|root,COG2172@2|Bacteria	2|Bacteria	T	sigma factor antagonist activity	rsbW	-	2.7.11.1	ko:K04757,ko:K06379,ko:K08282,ko:K17752	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
SX2_k127_4526842_1	177437.HRM2_43530	2.243e-13	74.0	COG1366@1|root,COG1366@2|Bacteria,1MZE8@1224|Proteobacteria,42V4W@68525|delta/epsilon subdivisions,2WR6H@28221|Deltaproteobacteria,2MM0J@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Belongs to the anti-sigma-factor antagonist family	rsbV	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
SX2_k127_4535209_1	573413.Spirs_2138	4.752e-103	342.0	COG0111@1|root,COG0111@2|Bacteria,2JA4I@203691|Spirochaetes	203691|Spirochaetes	C	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
SX2_k127_4535209_0	1122919.KB905559_gene1380	4.102e-106	350.0	COG1932@1|root,COG1932@2|Bacteria,1TP6Y@1239|Firmicutes,4HATT@91061|Bacilli,26SI9@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	GO:0003674,GO:0003824,GO:0004648,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
SX2_k127_454622_2	1191523.MROS_0053	2.743e-46	169.0	COG0297@1|root,COG0297@2|Bacteria	2|Bacteria	G	glycogen (starch) synthase activity	glgA	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
SX2_k127_454622_0	1379698.RBG1_1C00001G0936	1.364e-81	276.0	COG1335@1|root,COG1335@2|Bacteria,2NRGH@2323|unclassified Bacteria	2|Bacteria	Q	Isochorismatase family	-	-	3.5.1.110	ko:K09020	ko00240,ko01100,map00240,map01100	-	R09947,R09980	RC02737,RC02738	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
SX2_k127_454622_1	1410632.JHWW01000015_gene160	9.809e-56	200.0	COG2309@1|root,COG2309@2|Bacteria,1TP65@1239|Firmicutes,24AR8@186801|Clostridia	186801|Clostridia	E	aminopeptidase	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
SX2_k127_4556103_2	983917.RGE_41230	1.01e-13	78.0	COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,2VJBU@28216|Betaproteobacteria,1KJHS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Polysaccharide biosynthesis/export protein	kpsD	-	-	-	-	-	-	-	-	-	-	-	Caps_synth_GfcC,Poly_export,SLBB
SX2_k127_4556103_0	880073.Calab_0614	4.578e-123	412.0	COG0381@1|root,COG0381@2|Bacteria,2NNVT@2323|unclassified Bacteria	2|Bacteria	M	UDP-N-acetylglucosamine 2-epimerase	wecB	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
SX2_k127_4556103_1	635013.TherJR_2089	1.547e-54	203.0	COG0438@1|root,COG0438@2|Bacteria,1TQ1S@1239|Firmicutes,24GPH@186801|Clostridia,260YH@186807|Peptococcaceae	186801|Clostridia	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
SX2_k127_4576990_3	56780.SYN_00467	0.0004761	48.0	COG1633@1|root,COG1633@2|Bacteria,1NG4N@1224|Proteobacteria,42W3T@68525|delta/epsilon subdivisions,2WREZ@28221|Deltaproteobacteria,2MRRS@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
SX2_k127_4576990_0	1282361.ABAC402_14535	5.487e-41	162.0	COG0775@1|root,COG0775@2|Bacteria,1MY5S@1224|Proteobacteria,2TU7K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	phosphorylase	mtnN	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
SX2_k127_4576990_1	1123376.AUIU01000017_gene102	2.976e-11	66.0	COG3585@1|root,COG3585@2|Bacteria	2|Bacteria	H	molybdate ion transport	modE	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0042802,GO:0044424,GO:0044444,GO:0044464	-	ko:K02019	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,TOBE
SX2_k127_4576990_2	1396141.BATP01000039_gene1458	7.671e-05	46.0	COG2204@1|root,COG2204@2|Bacteria,46XBB@74201|Verrucomicrobia,2IVA2@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
SX2_k127_4600094_1	1379698.RBG1_1C00001G1447	2.727e-76	263.0	COG0805@1|root,COG0805@2|Bacteria,2NPGB@2323|unclassified Bacteria	2|Bacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009314,GO:0009628,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
SX2_k127_4600094_2	1379698.RBG1_1C00001G1448	6.41e-57	201.0	COG1327@1|root,COG1327@2|Bacteria,2NPEU@2323|unclassified Bacteria	2|Bacteria	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
SX2_k127_4600094_3	880072.Desac_0040	1.468e-50	188.0	COG1912@1|root,COG1912@2|Bacteria,1MV99@1224|Proteobacteria,42SHG@68525|delta/epsilon subdivisions,2WP1D@28221|Deltaproteobacteria,2MQGS@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
SX2_k127_4600094_5	1122185.N792_02665	3.122e-21	96.0	COG1324@1|root,COG1324@2|Bacteria,1N6TN@1224|Proteobacteria,1SCFM@1236|Gammaproteobacteria,1X7GP@135614|Xanthomonadales	135614|Xanthomonadales	P	protein involved in tolerance to divalent cations	cutA	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
SX2_k127_4600094_4	1123376.AUIU01000011_gene1003	6.11e-29	119.0	COG0011@1|root,COG0011@2|Bacteria,3J0QD@40117|Nitrospirae	40117|Nitrospirae	S	Thiamine-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Thiamine_BP
SX2_k127_4600094_0	1379698.RBG1_1C00001G1453	2.033e-93	310.0	COG0112@1|root,COG0112@2|Bacteria,2NP28@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	GO:0001505,GO:0003674,GO:0003824,GO:0004372,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006546,GO:0006563,GO:0006565,GO:0006730,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009070,GO:0009071,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0016742,GO:0017144,GO:0019264,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042133,GO:0042135,GO:0042136,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	iG2583_1286.G2583_3081,iIT341.HP0183	SHMT
SX2_k127_4612005_3	880073.Calab_0696	1.792e-25	123.0	COG1262@1|root,COG2911@1|root,COG3055@1|root,COG3934@1|root,COG5492@1|root,COG1262@2|Bacteria,COG2911@2|Bacteria,COG3055@2|Bacteria,COG3934@2|Bacteria,COG5492@2|Bacteria,2NPU7@2323|unclassified Bacteria	2|Bacteria	G	Sulfatase-modifying factor enzyme 1	-	-	3.2.1.1,3.2.1.51,3.2.1.78,3.2.1.81,3.2.1.89	ko:K01176,ko:K01206,ko:K01218,ko:K01219,ko:K01224	ko00051,ko00500,ko00511,ko01100,ko02024,ko04973,map00051,map00500,map00511,map01100,map02024,map04973	-	R01332,R02108,R02112,R11262	RC00467	ko00000,ko00001,ko01000,ko04147	-	GH13,GH26,GH29	-	Big_2,DctA-YdbH,FGE-sulfatase
SX2_k127_4612005_2	886293.Sinac_6103	4.062e-51	190.0	COG1212@1|root,COG1212@2|Bacteria,2IYWF@203682|Planctomycetes	203682|Planctomycetes	H	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
SX2_k127_4612005_0	1379698.RBG1_1C00001G0542	3.616e-243	762.0	COG0504@1|root,COG0504@2|Bacteria,2NNVG@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1276,iECO103_1326.ECO103_3323,iNJ661.Rv1699,iPC815.YPO3377	CTP_synth_N,GATase
SX2_k127_4612005_1	203275.BFO_0256	2.271e-70	248.0	COG2877@1|root,COG2877@2|Bacteria,4NENN@976|Bacteroidetes,2FN47@200643|Bacteroidia,22WRG@171551|Porphyromonadaceae	976|Bacteroidetes	M	Belongs to the KdsA family	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
SX2_k127_4662927_0	1379698.RBG1_1C00001G0884	1.296e-100	340.0	COG2182@1|root,COG2182@2|Bacteria	2|Bacteria	G	maltose binding	-	-	-	ko:K02027,ko:K17329	ko02010,map02010	M00207,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.33	-	-	SBP_bac_1,SBP_bac_8
SX2_k127_4662927_1	1379698.RBG1_1C00001G0883	1.911e-92	312.0	COG1175@1|root,COG1175@2|Bacteria,2NPDA@2323|unclassified Bacteria	2|Bacteria	G	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025,ko:K15771	ko02010,map02010	M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
SX2_k127_4662927_2	1379698.RBG1_1C00001G0882	1.097e-77	268.0	COG0395@1|root,COG0395@2|Bacteria,2NPFW@2323|unclassified Bacteria	2|Bacteria	U	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX2_k127_4668577_0	717231.Flexsi_1434	1.734e-227	715.0	COG1012@1|root,COG1012@2|Bacteria,2GEJJ@200930|Deferribacteres	200930|Deferribacteres	C	Aldehyde dehydrogenase family	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
SX2_k127_4668577_1	572479.Hprae_0513	1.445e-15	81.0	COG1633@1|root,COG1633@2|Bacteria,1V7QZ@1239|Firmicutes,24JY1@186801|Clostridia,3WBXC@53433|Halanaerobiales	186801|Clostridia	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
SX2_k127_4684868_4	1356854.N007_09790	5.221e-05	53.0	COG2608@1|root,COG2608@2|Bacteria,1VK5F@1239|Firmicutes,4HRF1@91061|Bacilli	91061|Bacilli	P	Heavy-metal-associated domain	copZ	-	-	ko:K07213	ko04978,map04978	-	-	-	ko00000,ko00001	-	-	-	HMA
SX2_k127_4684868_1	1047013.AQSP01000131_gene1815	5.428e-30	126.0	COG0526@1|root,COG0526@2|Bacteria,2NPYK@2323|unclassified Bacteria	2|Bacteria	O	Thioredoxin-like	resA	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Thioredoxin_8
SX2_k127_4684868_3	1265505.ATUG01000001_gene3090	2.957e-23	106.0	COG4232@1|root,COG4232@2|Bacteria,1R1X1@1224|Proteobacteria,42SD6@68525|delta/epsilon subdivisions,2WP2I@28221|Deltaproteobacteria,2MKNH@213118|Desulfobacterales	28221|Deltaproteobacteria	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_2
SX2_k127_4684868_2	1379698.RBG1_1C00001G0461	5.466e-27	117.0	COG2143@1|root,COG2143@2|Bacteria	2|Bacteria	O	COG2143 Thioredoxin-related protein	-	-	-	-	-	-	-	-	-	-	-	-	Thioredox_DsbH,Thioredoxin_2,Thioredoxin_7
SX2_k127_4684868_0	1379698.RBG1_1C00001G0460	1.499e-68	244.0	COG0587@1|root,COG0587@2|Bacteria,2NNVY@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase	dnaE	GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon
SX2_k127_4687740_4	273068.TTE1432	1.198e-15	78.0	COG1582@1|root,COG1582@2|Bacteria,1VKHB@1239|Firmicutes,24RWI@186801|Clostridia,42H8U@68295|Thermoanaerobacterales	186801|Clostridia	N	PFAM flagellar	flbD	-	-	ko:K02385	-	-	-	-	ko00000,ko02035	-	-	-	FlbD
SX2_k127_4687740_5	518766.Rmar_0769	3.662e-12	76.0	COG1580@1|root,COG1580@2|Bacteria,4PF8F@976|Bacteroidetes,1FKAE@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	N	Controls the rotational direction of flagella during chemotaxis	-	-	-	ko:K02415	-	-	-	-	ko00000,ko02035	-	-	-	FliL
SX2_k127_4687740_1	1123511.KB905845_gene2777	2.779e-71	252.0	COG1868@1|root,COG1868@2|Bacteria,1TPTM@1239|Firmicutes,4H2GJ@909932|Negativicutes	909932|Negativicutes	N	flagellar motor switch protein FliM	fliM	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
SX2_k127_4687740_2	935836.JAEL01000002_gene554	5.045e-33	135.0	COG1776@1|root,COG1886@1|root,COG1776@2|Bacteria,COG1886@2|Bacteria,1TPT8@1239|Firmicutes,4HC56@91061|Bacilli,1ZB7S@1386|Bacillus	91061|Bacilli	N	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliY	GO:0003674,GO:0003824,GO:0004721,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006935,GO:0008150,GO:0008152,GO:0009605,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0032879,GO:0036211,GO:0040011,GO:0040012,GO:0042221,GO:0042330,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0050896,GO:0051270,GO:0065007,GO:0071704,GO:0140096,GO:1901564,GO:1902021,GO:2000145	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	CheC,FliMN_C
SX2_k127_4687740_6	331113.SNE_A10950	0.0001086	51.0	COG3190@1|root,COG3190@2|Bacteria,2JGJY@204428|Chlamydiae	204428|Chlamydiae	N	Flagellar biosynthesis protein, FliO	-	-	-	ko:K02418	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliO
SX2_k127_4687740_0	574087.Acear_1628	1.013e-79	275.0	COG1338@1|root,COG1338@2|Bacteria,1TPIE@1239|Firmicutes,2487C@186801|Clostridia,3WA60@53433|Halanaerobiales	186801|Clostridia	N	Plays a role in the flagellum-specific transport system	fliP	-	-	ko:K02419	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliP
SX2_k127_4687740_3	1536775.H70737_18750	1.163e-23	103.0	COG1987@1|root,COG1987@2|Bacteria,1VEHF@1239|Firmicutes,4HKVS@91061|Bacilli,26YZI@186822|Paenibacillaceae	91061|Bacilli	N	Role in flagellar biosynthesis	fliQ	-	-	ko:K02420	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_3
SX2_k127_4688356_0	1379698.RBG1_1C00001G0317	3.651e-225	715.0	COG0143@1|root,COG0143@2|Bacteria,2NNTX@2323|unclassified Bacteria	2|Bacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
SX2_k127_4688356_1	862517.HMPREF9225_0238	1.012e-54	197.0	COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,248HE@186801|Clostridia,22G6R@1570339|Peptoniphilaceae	186801|Clostridia	L	hydrolase, TatD family	tatD	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
SX2_k127_4690663_0	572479.Hprae_0564	2.849e-137	447.0	COG1298@1|root,COG1298@2|Bacteria,1TQBM@1239|Firmicutes,248F5@186801|Clostridia,3WABD@53433|Halanaerobiales	186801|Clostridia	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
SX2_k127_4690663_1	667014.Thein_0186	4.115e-82	285.0	COG1377@1|root,COG1377@2|Bacteria,2GGWD@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	NU	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhB	-	-	ko:K02401	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_2
SX2_k127_4690663_2	218284.CCDN010000001_gene1914	9.289e-10	61.0	COG1684@1|root,COG1684@2|Bacteria,1TRB2@1239|Firmicutes,4HA2E@91061|Bacilli,1ZBJF@1386|Bacillus	91061|Bacilli	N	Flagellar biosynthetic protein FliR	fliR	-	-	ko:K02421	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1
SX2_k127_4693006_1	1379698.RBG1_1C00001G1665	5.135e-67	236.0	COG0845@1|root,COG0845@2|Bacteria,2NQ2U@2323|unclassified Bacteria	2|Bacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	acrA	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
SX2_k127_4693006_0	573413.Spirs_0164	1.049e-175	571.0	COG0370@1|root,COG0370@2|Bacteria,2J5ZF@203691|Spirochaetes	203691|Spirochaetes	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoA,FeoB_C,FeoB_N,Gate
SX2_k127_4708574_0	518766.Rmar_2632	5.406e-143	466.0	COG1160@1|root,COG1160@2|Bacteria,4NE2J@976|Bacteroidetes,1FIK1@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
SX2_k127_4708574_1	1121403.AUCV01000034_gene3844	6.75e-53	196.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,42N67@68525|delta/epsilon subdivisions,2WPKC@28221|Deltaproteobacteria,2MJE6@213118|Desulfobacterales	28221|Deltaproteobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
SX2_k127_4708574_2	1279009.ADICEAN_03392	1.141e-21	98.0	COG0859@1|root,COG0859@2|Bacteria,4NEPH@976|Bacteroidetes,47MA4@768503|Cytophagia	976|Bacteroidetes	M	PFAM glycosyl transferase family 9	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
SX2_k127_4708574_4	1379698.RBG1_1C00001G1043	3.006e-18	91.0	COG0859@1|root,COG0859@2|Bacteria,2NP5P@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferase, family 9	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
SX2_k127_4713477_1	1121396.KB893057_gene2447	5.232e-12	70.0	2EAFJ@1|root,334IY@2|Bacteria,1NA2Y@1224|Proteobacteria,42VJ1@68525|delta/epsilon subdivisions,2WRKE@28221|Deltaproteobacteria,2MKY4@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1844)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1844
SX2_k127_4713477_0	1379698.RBG1_1C00001G0434	1.478e-50	192.0	COG0812@1|root,COG0812@2|Bacteria,2NPHQ@2323|unclassified Bacteria	2|Bacteria	M	Cell wall formation	murB	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0055114,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
SX2_k127_4714828_0	635013.TherJR_0845	9.854e-20	94.0	COG0730@1|root,COG0730@2|Bacteria,1TRFG@1239|Firmicutes,258JQ@186801|Clostridia,2605C@186807|Peptococcaceae	186801|Clostridia	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
SX2_k127_4724563_1	886379.AEWI01000013_gene2117	2.01e-05	56.0	2D6WA@1|root,32TMZ@2|Bacteria,4NU16@976|Bacteroidetes,2FYYU@200643|Bacteroidia,3XKM2@558415|Marinilabiliaceae	976|Bacteroidetes	S	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
SX2_k127_4724563_0	1499967.BAYZ01000095_gene4168	1.821e-08	61.0	COG3225@1|root,COG3225@2|Bacteria,2NNVN@2323|unclassified Bacteria	2|Bacteria	N	ABC-type uncharacterized transport system	gldG	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC_transp_aux
SX2_k127_4740459_3	686340.Metal_3381	4.738e-42	160.0	COG1943@1|root,COG1943@2|Bacteria,1MZZT@1224|Proteobacteria,1S9JG@1236|Gammaproteobacteria,1XGEA@135618|Methylococcales	135618|Methylococcales	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
SX2_k127_4740459_1	1449126.JQKL01000002_gene1589	1.029e-94	323.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia	186801|Clostridia	C	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SX2_k127_4740459_2	1379698.RBG1_1C00001G1472	4.359e-74	258.0	COG0491@1|root,COG0491@2|Bacteria,2NPRD@2323|unclassified Bacteria	2|Bacteria	S	Metallo-beta-lactamase superfamily	ytnP	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SX2_k127_4740459_0	1379698.RBG1_1C00001G1471	2.735e-230	719.0	COG4799@1|root,COG4799@2|Bacteria,2NNWQ@2323|unclassified Bacteria	2|Bacteria	I	carboxyl transferase	pccB	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
SX2_k127_475171_0	247490.KSU1_A0077	1.469e-197	620.0	COG3259@1|root,COG3259@2|Bacteria,2IYS2@203682|Planctomycetes	203682|Planctomycetes	C	Nickel-dependent hydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NiFeSe_Hases
SX2_k127_475171_1	1380391.JIAS01000013_gene3651	1.555e-97	335.0	COG1167@1|root,COG1167@2|Bacteria,1MUJE@1224|Proteobacteria,2TQZZ@28211|Alphaproteobacteria,2JPG0@204441|Rhodospirillales	204441|Rhodospirillales	K	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2,GntR
SX2_k127_475171_2	1304284.L21TH_1924	3.361e-17	83.0	COG1167@1|root,COG1167@2|Bacteria,1TPS5@1239|Firmicutes,248ZB@186801|Clostridia,36EK3@31979|Clostridiaceae	186801|Clostridia	K	aminotransferase class I and II	-	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
SX2_k127_4780042_0	1307759.JOMJ01000003_gene38	3.198e-72	251.0	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,42QJT@68525|delta/epsilon subdivisions,2WJ1S@28221|Deltaproteobacteria,2M8MF@213115|Desulfovibrionales	28221|Deltaproteobacteria	NT	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP	cheR	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
SX2_k127_4780042_2	247490.KSU1_D0598	5.619e-25	113.0	COG2199@1|root,COG3706@2|Bacteria,2J108@203682|Planctomycetes	203682|Planctomycetes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
SX2_k127_4780042_3	502025.Hoch_4444	1.903e-21	99.0	COG2203@1|root,COG2204@1|root,COG3437@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42T7G@68525|delta/epsilon subdivisions,2WKC5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	metal-dependent phosphohydrolase HD	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5,Response_reg
SX2_k127_4780042_1	179408.Osc7112_4859	4.079e-25	115.0	COG1413@1|root,COG1413@2|Bacteria,1G233@1117|Cyanobacteria,1H7RE@1150|Oscillatoriales	1117|Cyanobacteria	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
SX2_k127_4790959_0	243231.GSU2276	4.435e-123	406.0	COG4198@1|root,COG4198@2|Bacteria,1NPPY@1224|Proteobacteria,42PTC@68525|delta/epsilon subdivisions,2WM3S@28221|Deltaproteobacteria,43TWP@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
SX2_k127_4792401_0	945713.IALB_1644	2.75e-140	472.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec
SX2_k127_4792401_3	1453500.AT05_09380	6.229e-16	90.0	COG3391@1|root,COG3391@2|Bacteria,4P4CR@976|Bacteroidetes	976|Bacteroidetes	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4792401_2	706587.Desti_0293	4.122e-42	164.0	COG1633@1|root,COG1633@2|Bacteria,1N4PW@1224|Proteobacteria,42UZG@68525|delta/epsilon subdivisions,2WNGQ@28221|Deltaproteobacteria,2MS9U@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
SX2_k127_4792401_1	909663.KI867150_gene397	9.753e-92	305.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WJHC@28221|Deltaproteobacteria,2MREN@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	TIGRFAM glutamate synthase (NADPH), homotetrameric	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
SX2_k127_4808718_1	404380.Gbem_2161	9.076e-13	70.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria	1224|Proteobacteria	T	signal transduction histidine kinase	ntrY	-	2.7.13.3	ko:K07709	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,PAS,PAS_8
SX2_k127_4808718_3	1158318.ATXC01000001_gene73	6.523e-10	62.0	COG2331@1|root,COG2331@2|Bacteria	2|Bacteria	P	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
SX2_k127_4808718_4	883096.HMPREF9699_00181	4.929e-06	52.0	COG0607@1|root,COG0607@2|Bacteria	2|Bacteria	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	yibN	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
SX2_k127_4808718_0	1094508.Tsac_2093	2.26e-138	455.0	COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,2482P@186801|Clostridia,42ETH@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
SX2_k127_4818910_0	945713.IALB_0720	3.6e-131	428.0	COG2217@1|root,COG2608@1|root,COG2217@2|Bacteria,COG2608@2|Bacteria	2|Bacteria	P	mercury ion transmembrane transporter activity	fixI	GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
SX2_k127_4862227_2	671143.DAMO_2708	6.228e-08	54.0	COG0839@1|root,COG0839@2|Bacteria,2NPUC@2323|unclassified Bacteria	2|Bacteria	C	Belongs to the complex I subunit 6 family	ndhG	-	1.6.5.3	ko:K00339,ko:K05578	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
SX2_k127_4862227_1	671143.DAMO_2707	5.256e-35	138.0	COG0713@1|root,COG0713@2|Bacteria,2NQ6R@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204	1.6.5.3	ko:K00340,ko:K05576	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
SX2_k127_4862227_0	1449126.JQKL01000022_gene111	6.662e-66	232.0	COG1009@1|root,COG1009@2|Bacteria,1TQW4@1239|Firmicutes,24A16@186801|Clostridia	186801|Clostridia	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5	ndhF	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
SX2_k127_4875467_0	945713.IALB_0006	8.525e-234	738.0	COG0188@1|root,COG0188@2|Bacteria	2|Bacteria	L	DNA topoisomerase II activity	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
SX2_k127_4900515_3	1380386.JIAW01000013_gene2616	2.09e-05	51.0	COG0515@1|root,COG0515@2|Bacteria,2H5ZS@201174|Actinobacteria,232IX@1762|Mycobacteriaceae	201174|Actinobacteria	KLT	PFAM Protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
SX2_k127_4900515_1	1382359.JIAL01000001_gene2561	2.317e-13	81.0	2AC2T@1|root,311KW@2|Bacteria,3Y4QM@57723|Acidobacteria,2JMHZ@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4900515_0	880073.Calab_0921	9.4e-21	104.0	COG1361@1|root,COG1361@2|Bacteria	2|Bacteria	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157,FctA,Peptidase_M43
SX2_k127_4900515_2	459349.CLOAM1563	1.339e-08	56.0	COG4412@1|root,COG4412@2|Bacteria	2|Bacteria	S	peptidase activity, acting on L-amino acid peptides	-	-	3.4.17.22	ko:K07752	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	CBM_6,Cellulase,DUF4859,F5_F8_type_C,FlgD_ig
SX2_k127_4902348_3	706587.Desti_0774	5.804e-18	93.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42PY9@68525|delta/epsilon subdivisions,2WMGG@28221|Deltaproteobacteria,2MRX1@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	coenzyme F390	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	-
SX2_k127_4902348_2	526227.Mesil_1054	6.289e-37	149.0	COG0637@1|root,COG0637@2|Bacteria,1WNGW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	HAD-hyrolase-like	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
SX2_k127_4902348_1	1379698.RBG1_1C00001G1176	8.383e-46	176.0	COG1216@1|root,COG1216@2|Bacteria,2NS4X@2323|unclassified Bacteria	2|Bacteria	S	Glycosyl transferase family 2	XK27_08075	-	-	-	-	-	-	-	-	-	-	-	DUF2062,Glycos_transf_2,GtrA,Lip_A_acyltrans
SX2_k127_4902348_0	671143.DAMO_1380	4.308e-69	242.0	COG0496@1|root,COG0496@2|Bacteria,2NPCG@2323|unclassified Bacteria	2|Bacteria	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	GO:0003674,GO:0003824,GO:0004309,GO:0005488,GO:0005515,GO:0006139,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008254,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009125,GO:0009129,GO:0009131,GO:0009158,GO:0009161,GO:0009164,GO:0009166,GO:0009173,GO:0009175,GO:0009218,GO:0009222,GO:0009259,GO:0009261,GO:0009987,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030145,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042578,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046049,GO:0046050,GO:0046131,GO:0046133,GO:0046135,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	iSFxv_1172.SFxv_3035	SurE
SX2_k127_4912071_2	194439.CT1278	1.206e-22	98.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1FE4X@1090|Chlorobi	1090|Chlorobi	C	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
SX2_k127_4912071_0	472759.Nhal_3039	1.655e-25	108.0	COG3476@1|root,COG3476@2|Bacteria,1MZC1@1224|Proteobacteria,1SCEH@1236|Gammaproteobacteria,1WZAH@135613|Chromatiales	135613|Chromatiales	T	TspO/MBR family	-	-	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
SX2_k127_4912071_3	269796.Rru_A2272	4.347e-13	78.0	COG3476@1|root,COG3476@2|Bacteria,1MZC1@1224|Proteobacteria,2UBYB@28211|Alphaproteobacteria,2JTMR@204441|Rhodospirillales	204441|Rhodospirillales	T	TspO/MBR family	-	-	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
SX2_k127_4912071_4	1565129.JSFF01000014_gene438	2.336e-12	74.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,1RYRB@1236|Gammaproteobacteria,2QAIB@267890|Shewanellaceae	1236|Gammaproteobacteria	S	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SX2_k127_4912071_1	1122176.KB903532_gene2525	1.347e-23	104.0	COG1680@1|root,COG1729@1|root,COG1680@2|Bacteria,COG1729@2|Bacteria,4NI1Z@976|Bacteroidetes,1IWFT@117747|Sphingobacteriia	976|Bacteroidetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471,TPR_2,TPR_8
SX2_k127_4924268_0	1408254.T458_16735	9.553e-89	297.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,4H9SD@91061|Bacilli,26QJA@186822|Paenibacillaceae	91061|Bacilli	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF3	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
SX2_k127_4924268_2	1379698.RBG1_1C00001G1823	1.081e-58	214.0	COG0571@1|root,COG0571@2|Bacteria,2NPCJ@2323|unclassified Bacteria	2|Bacteria	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
SX2_k127_4924268_1	1379698.RBG1_1C00001G1822	9.415e-75	259.0	COG2086@1|root,COG2086@2|Bacteria,2NP4J@2323|unclassified Bacteria	2|Bacteria	C	Electron transfer flavoprotein	etfB	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016020,GO:0016491,GO:0022900,GO:0030312,GO:0040007,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
SX2_k127_49248_2	1125863.JAFN01000001_gene1446	5.777e-09	59.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
SX2_k127_49248_1	243231.GSU1319	4.551e-60	224.0	COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,43C4K@68525|delta/epsilon subdivisions,2X7F1@28221|Deltaproteobacteria,43TX3@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Domains HisKA, HATPase_c	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
SX2_k127_49248_0	706587.Desti_3021	3.435e-145	478.0	COG2202@1|root,COG2204@1|root,COG3850@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2204@2|Bacteria,COG3850@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIU5@28221|Deltaproteobacteria,2MQZQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
SX2_k127_4933606_3	1379698.RBG1_1C00001G1627	2.288e-43	165.0	COG0465@1|root,COG0465@2|Bacteria,2NNQ5@2323|unclassified Bacteria	2|Bacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
SX2_k127_4933606_2	536232.CLM_4011	1.654e-46	173.0	COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,24FR4@186801|Clostridia,36HYM@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
SX2_k127_4933606_1	1379698.RBG1_1C00001G1629	2.451e-74	268.0	COG0037@1|root,COG0037@2|Bacteria,2NPAZ@2323|unclassified Bacteria	2|Bacteria	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS_C
SX2_k127_4933606_0	1125863.JAFN01000001_gene336	3.259e-112	383.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42RF9@68525|delta/epsilon subdivisions,2WNQF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
SX2_k127_4933606_4	243231.GSU1955	5.009e-34	147.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42PY9@68525|delta/epsilon subdivisions,2WMGG@28221|Deltaproteobacteria,43VMS@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	coenzyme F390	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	-
SX2_k127_4952975_4	1437425.CSEC_0648	8.907e-08	55.0	COG0356@1|root,COG0356@2|Bacteria,2JFFC@204428|Chlamydiae	204428|Chlamydiae	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
SX2_k127_4952975_3	1379698.RBG1_1C00001G0147	3.707e-23	100.0	COG0636@1|root,COG0636@2|Bacteria,2NQ21@2323|unclassified Bacteria	2|Bacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
SX2_k127_4952975_1	1379698.RBG1_1C00001G0148	1.936e-41	158.0	COG0711@1|root,COG0711@2|Bacteria,2NQ34@2323|unclassified Bacteria	2|Bacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
SX2_k127_4952975_2	1121428.DESHY_30122___1	2.468e-28	121.0	COG0712@1|root,COG0712@2|Bacteria,1VAG3@1239|Firmicutes,24MSA@186801|Clostridia,261U6@186807|Peptococcaceae	186801|Clostridia	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
SX2_k127_4952975_0	1379698.RBG1_1C00001G0150	9.387e-188	591.0	COG0056@1|root,COG0056@2|Bacteria,2NP0S@2323|unclassified Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	iIT341.HP1134,iSB619.SA_RS10975,iSbBS512_1146.SbBS512_E4187	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
SX2_k127_4994345_0	658659.HMPREF0983_01382	1.161e-17	94.0	2C3ZC@1|root,32RD1@2|Bacteria,1V6CS@1239|Firmicutes,3VSXP@526524|Erysipelotrichia	526524|Erysipelotrichia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_4994345_1	797209.ZOD2009_08758	3.429e-14	78.0	COG0500@1|root,arCOG01791@2157|Archaea	2157|Archaea	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
SX2_k127_5002299_0	665571.STHERM_c09350	5.086e-33	134.0	COG1315@1|root,COG1315@2|Bacteria,2J5S8@203691|Spirochaetes	203691|Spirochaetes	L	COGs COG1315 polymerase most protein contain PALM domain HD hydrolase domain and Zn-ribbon domain	-	-	-	ko:K09749	-	-	-	-	ko00000	-	-	-	FapA,Jag_N
SX2_k127_5002299_2	1184267.A11Q_933	1.28e-21	100.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2MTR9@213481|Bdellovibrionales,2WIT0@28221|Deltaproteobacteria	213481|Bdellovibrionales	T	two component, sigma54 specific, transcriptional regulator, Fis family	pilR	-	-	ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
SX2_k127_5002299_3	1123274.KB899414_gene3652	2.548e-08	64.0	COG2201@1|root,COG2201@2|Bacteria,2J62V@203691|Spirochaetes	203691|Spirochaetes	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
SX2_k127_5002299_1	667014.Thein_0014	4.05e-26	112.0	COG0745@1|root,COG0745@2|Bacteria,2GIHU@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
SX2_k127_5010798_0	639282.DEFDS_0301	8.806e-105	352.0	COG2217@1|root,COG2217@2|Bacteria,2GEJ6@200930|Deferribacteres	200930|Deferribacteres	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
SX2_k127_5013301_0	653733.Selin_1351	6.131e-94	317.0	COG0138@1|root,COG0138@2|Bacteria	2|Bacteria	F	bifunctional purine biosynthesis protein purh	purH	GO:0003674,GO:0003824,GO:0004643,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iEcHS_1320.EcHS_A4240,iPC815.YPO3728	AICARFT_IMPCHas,MGS
SX2_k127_5013301_1	335543.Sfum_1263	1.029e-62	220.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,42M8A@68525|delta/epsilon subdivisions,2WJY0@28221|Deltaproteobacteria,2MQRU@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	PFAM SAICAR synthetase	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
SX2_k127_501737_0	1379698.RBG1_1C00001G0998	1.624e-137	444.0	COG0825@1|root,COG0825@2|Bacteria,2NNVQ@2323|unclassified Bacteria	2|Bacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962,ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.accA	ACCA
SX2_k127_501737_4	760142.Hipma_0205	1.34e-14	76.0	COG2835@1|root,COG2835@2|Bacteria,1Q1BG@1224|Proteobacteria,42WTN@68525|delta/epsilon subdivisions,2WSI9@28221|Deltaproteobacteria,2M7FV@213113|Desulfurellales	28221|Deltaproteobacteria	S	Trm112p-like protein	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
SX2_k127_501737_1	1379698.RBG1_1C00001G1000	1.83e-60	211.0	COG1762@1|root,COG1762@2|Bacteria,2NPVC@2323|unclassified Bacteria	2|Bacteria	G	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	-	-	2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2
SX2_k127_501737_2	1379698.RBG1_1C00001G1001	4.368e-35	144.0	COG1792@1|root,COG1792@2|Bacteria,2NPNX@2323|unclassified Bacteria	2|Bacteria	M	Cell shape-determining protein MreC	mreC	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007163,GO:0008150,GO:0008360,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0030428,GO:0031224,GO:0031226,GO:0042546,GO:0043621,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071554,GO:0071840,GO:0071944,GO:0071963	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
SX2_k127_501737_5	1379698.RBG1_1C00001G1002	3.278e-11	70.0	29494@1|root,2ZRPB@2|Bacteria	2|Bacteria	S	rod shape-determining protein MreD	-	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
SX2_k127_501737_3	457570.Nther_0518	2.255e-17	88.0	COG0768@1|root,COG0768@2|Bacteria,1TQHY@1239|Firmicutes,2480Z@186801|Clostridia	186801|Clostridia	M	penicillin-binding protein	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
SX2_k127_5021804_3	880073.Calab_1998	3.595e-08	56.0	COG1646@1|root,COG1646@2|Bacteria,2NQW0@2323|unclassified Bacteria	2|Bacteria	I	PcrB family	pcrB	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576	-	ko:K07094	-	-	-	-	ko00000,ko01000	-	-	-	PcrB
SX2_k127_5021804_0	1191523.MROS_1442	6.142e-47	175.0	COG0279@1|root,COG0279@2|Bacteria	2|Bacteria	G	D-glycero-D-manno-heptose 7-phosphate metabolic process	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	HupF_HypC,SIS_2
SX2_k127_5021804_2	324602.Caur_3495	1.221e-21	97.0	COG1669@1|root,COG1669@2|Bacteria,2GB2M@200795|Chloroflexi,377T5@32061|Chloroflexia	32061|Chloroflexia	L	PFAM DNA polymerase beta domain protein region	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
SX2_k127_5021804_1	391009.Tmel_1695	1.251e-37	145.0	COG2361@1|root,COG2361@2|Bacteria,2GDEF@200918|Thermotogae	200918|Thermotogae	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
SX2_k127_5052679_2	945713.IALB_0621	0.0008199	48.0	COG2260@1|root,COG2260@2|Bacteria	2|Bacteria	J	snoRNA binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF2007
SX2_k127_5052679_1	1379698.RBG1_1C00001G0750	6.841e-39	153.0	COG2143@1|root,COG2143@2|Bacteria	2|Bacteria	O	COG2143 Thioredoxin-related protein	soxS	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	Thioredoxin_2,Thioredoxin_7
SX2_k127_5052679_0	1379698.RBG1_1C00001G1497	1.183e-192	612.0	COG1003@1|root,COG1003@2|Bacteria,2NNSG@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019464,GO:0019752,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS11880	Aminotran_5,GDC-P
SX2_k127_5057654_0	1379281.AVAG01000026_gene1636	4.546e-42	160.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,2M91Y@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM sigma-54 factor interaction domain-containing protein	ntrX	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
SX2_k127_5057654_1	518766.Rmar_2626	2.423e-05	57.0	COG0729@1|root,COG0729@2|Bacteria	2|Bacteria	M	surface antigen	-	-	-	ko:K07277,ko:K07278	-	-	-	-	ko00000,ko02000,ko03029	1.B.33,1.B.33.2.4	-	-	Bac_surface_Ag,POTRA,Peptidase_S74
SX2_k127_5074678_0	1379698.RBG1_1C00001G0584	1.829e-93	330.0	COG2373@1|root,COG2931@1|root,COG3209@1|root,COG3291@1|root,COG3386@1|root,COG2373@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,COG3291@2|Bacteria,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.4.24.40	ko:K01406,ko:K14274,ko:K20276,ko:K21449	ko00040,ko01503,ko02024,map00040,map01503,map02024	-	R02427	RC00713	ko00000,ko00001,ko01000,ko01002,ko02000	1.B.40.2	-	-	Calx-beta,DUF4347,He_PIG,Ice_nucleation,SGL
SX2_k127_5081469_0	671143.DAMO_0568	5.704e-180	583.0	COG0480@1|root,COG0480@2|Bacteria,2NNQD@2323|unclassified Bacteria	2|Bacteria	J	elongation factor G	fusA-1	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
SX2_k127_5089034_0	1379698.RBG1_1C00001G1816	4.348e-50	196.0	COG0457@1|root,COG1807@1|root,COG0457@2|Bacteria,COG1807@2|Bacteria,2NR9R@2323|unclassified Bacteria	2|Bacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723,PMT_2,TPR_8
SX2_k127_509024_3	765420.OSCT_2708	8.185e-14	71.0	COG0172@1|root,COG0172@2|Bacteria,2G5PD@200795|Chloroflexi,3766F@32061|Chloroflexia	32061|Chloroflexia	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
SX2_k127_509024_1	1379698.RBG1_1C00001G1544	5.286e-111	373.0	COG4191@1|root,COG4191@2|Bacteria,2NPC5@2323|unclassified Bacteria	2|Bacteria	T	Integral membrane sensor signal transduction histidine kinase	vicK	-	2.1.1.80,2.7.13.3,3.1.1.61	ko:K07709,ko:K13924	ko02020,ko02030,map02020,map02030	M00499,M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA
SX2_k127_509024_0	1379698.RBG1_1C00001G1545	9.019e-112	369.0	COG0745@1|root,COG0745@2|Bacteria,2NNXK@2323|unclassified Bacteria	2|Bacteria	KT	PglZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PglZ,Response_reg
SX2_k127_509024_2	1379698.RBG1_1C00001G1545	1.465e-68	237.0	COG0745@1|root,COG0745@2|Bacteria,2NNXK@2323|unclassified Bacteria	2|Bacteria	KT	PglZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PglZ,Response_reg
SX2_k127_5114582_0	1196322.A370_05896	6.546e-34	149.0	COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,24CD5@186801|Clostridia,36JX7@31979|Clostridiaceae	186801|Clostridia	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	3.4.21.66	ko:K08651,ko:K13274,ko:K14645,ko:K20486	ko02020,ko02024,map02020,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Big_2,Peptidase_S8,SLH
SX2_k127_5123269_0	1463936.JOJI01000036_gene2091	4.155e-17	89.0	COG1595@1|root,COG1595@2|Bacteria,2GM3E@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4
SX2_k127_5140879_0	290397.Adeh_0055	6.429e-57	212.0	COG1236@1|root,COG1236@2|Bacteria,1MV7U@1224|Proteobacteria	1224|Proteobacteria	J	Exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Lactamase_B_2
SX2_k127_5140879_1	497964.CfE428DRAFT_6003	5.134e-33	137.0	COG1408@1|root,COG1408@2|Bacteria,46T0Y@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
SX2_k127_5144252_1	1379698.RBG1_1C00001G1854	8.152e-85	284.0	COG0192@1|root,COG0192@2|Bacteria,2NNYF@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
SX2_k127_5144252_0	1379698.RBG1_1C00001G1855	8.095e-184	583.0	COG0499@1|root,COG0499@2|Bacteria,2NNQE@2323|unclassified Bacteria	2|Bacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
SX2_k127_5144252_2	1379698.RBG1_1C00001G0548	1.997e-23	108.0	COG3117@1|root,COG3117@2|Bacteria,2NQ8Q@2323|unclassified Bacteria	2|Bacteria	S	Lipopolysaccharide-assembly, LptC-related	lptC	-	-	ko:K09774,ko:K11719	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptC
SX2_k127_5146202_0	1379698.RBG1_1C00001G0182	1.912e-53	195.0	COG0340@1|root,COG0340@2|Bacteria,2NPG2@2323|unclassified Bacteria	2|Bacteria	H	biotin acetyl-CoA-carboxylase ligase	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
SX2_k127_5147759_3	880073.Calab_2216	4.194e-25	115.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	ebh	-	-	-	-	-	-	-	-	-	-	-	DUF1611,Inhibitor_I9,Peptidase_S8,SLH
SX2_k127_5147759_0	880073.Calab_2961	4.596e-65	235.0	COG2067@1|root,COG2067@2|Bacteria,2NRA4@2323|unclassified Bacteria	2|Bacteria	I	PFAM Uncharacterised protein family (UPF0164)	-	-	-	-	-	-	-	-	-	-	-	-	UPF0164
SX2_k127_5147759_4	221109.22776709	0.0005328	49.0	COG0454@1|root,COG0456@2|Bacteria,1V7Q4@1239|Firmicutes,4HHHA@91061|Bacilli,23KMR@182709|Oceanobacillus	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
SX2_k127_5147759_1	331113.SNE_A14190	4.191e-54	199.0	COG0500@1|root,COG2226@2|Bacteria,2JG4F@204428|Chlamydiae	204428|Chlamydiae	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
SX2_k127_5147759_2	523850.TON_1133	2.324e-52	193.0	COG2876@1|root,arCOG01049@2157|Archaea,2XWR8@28890|Euryarchaeota,242IN@183968|Thermococci	183968|Thermococci	E	NeuB family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
SX2_k127_5154876_0	643473.KB235930_gene3558	1.313e-15	89.0	COG2706@1|root,COG2931@1|root,COG3391@1|root,COG2706@2|Bacteria,COG2931@2|Bacteria,COG3391@2|Bacteria,1GQ7W@1117|Cyanobacteria,1HTNJ@1161|Nostocales	1117|Cyanobacteria	Q	Domain of unknown function (DUF4114)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4114,FG-GAP
SX2_k127_519703_2	316055.RPE_0468	3.385e-09	61.0	28M2G@1|root,2ZAGX@2|Bacteria,1QDCH@1224|Proteobacteria,2U6R1@28211|Alphaproteobacteria,3K5K0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3800
SX2_k127_519703_0	700598.Niako_4484	5.538e-43	170.0	2DKFZ@1|root,309D6@2|Bacteria,4NEGR@976|Bacteroidetes,1IY3C@117747|Sphingobacteriia	976|Bacteroidetes	S	Domain of unknown function (DUF4382)	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,DUF4382
SX2_k127_519703_3	1306990.BARG01000047_gene5672	2.968e-07	53.0	COG0702@1|root,COG0702@2|Bacteria,2HBFK@201174|Actinobacteria	201174|Actinobacteria	GM	NmrA family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
SX2_k127_5204555_3	272562.CA_C3550	4.471e-11	70.0	COG1668@1|root,COG1668@2|Bacteria,1TQNC@1239|Firmicutes,2489Z@186801|Clostridia,36GGI@31979|Clostridiaceae	186801|Clostridia	CP	ABC-2 family transporter protein	natB	-	-	ko:K09696	ko02010,ko02020,map02010,map02020	M00253	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.115	-	-	ABC2_membrane_2,ABC2_membrane_3,Abi
SX2_k127_5204555_1	452637.Oter_1528	1.602e-93	312.0	COG4555@1|root,COG4555@2|Bacteria	2|Bacteria	CP	ABC transporter	natA	-	3.6.3.7	ko:K01990,ko:K09697	ko02010,ko02020,map02010,map02020	M00253,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.115	-	iYO844.BSU02750	ABC_tran
SX2_k127_5204555_0	1379698.RBG1_1C00001G0290	3.164e-124	426.0	COG0308@1|root,COG0308@2|Bacteria,2NPGQ@2323|unclassified Bacteria	2|Bacteria	E	aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1,PD40,Peptidase_M1
SX2_k127_5204555_2	1191523.MROS_1854	1.256e-23	104.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	rsbV	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
SX2_k127_5242914_3	290318.Cvib_0193	2.201e-33	130.0	COG1403@1|root,COG1403@2|Bacteria,1FDXZ@1090|Chlorobi	1090|Chlorobi	L	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH,HNH_5
SX2_k127_5242914_0	1379698.RBG1_1C00001G1230	1.225e-140	452.0	COG0180@1|root,COG0180@2|Bacteria,2NNQX@2323|unclassified Bacteria	2|Bacteria	J	tRNA synthetases class I (W and Y)	trpS	GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
SX2_k127_5242914_1	945713.IALB_1557	1.063e-54	202.0	COG1354@1|root,COG1354@2|Bacteria	2|Bacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
SX2_k127_5242914_2	1379698.RBG1_1C00001G1228	3.406e-46	174.0	COG1386@1|root,COG1386@2|Bacteria,2NPPM@2323|unclassified Bacteria	2|Bacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
SX2_k127_5252038_0	1379698.RBG1_1C00001G1080	7.819e-114	384.0	COG2091@1|root,COG2091@2|Bacteria,2NQPA@2323|unclassified Bacteria	2|Bacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
SX2_k127_5262650_4	1379698.RBG1_1C00001G1326	7.07e-19	86.0	COG2006@1|root,COG2006@2|Bacteria,2NPTK@2323|unclassified Bacteria	2|Bacteria	C	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4
SX2_k127_5262650_3	1379698.RBG1_1C00001G1326	4.191e-36	142.0	COG2006@1|root,COG2006@2|Bacteria,2NPTK@2323|unclassified Bacteria	2|Bacteria	C	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4
SX2_k127_5262650_0	545264.KB898744_gene2178	5.97e-75	264.0	COG0726@1|root,COG0726@2|Bacteria,1MWMZ@1224|Proteobacteria,1RREJ@1236|Gammaproteobacteria,1WWEV@135613|Chromatiales	135613|Chromatiales	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3473,Polysacc_deac_1
SX2_k127_5262650_2	517418.Ctha_2522	3.804e-36	146.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1FENH@1090|Chlorobi	1090|Chlorobi	D	G-rich domain on putative tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31,GNVR,Wzz
SX2_k127_5262650_7	388467.A19Y_2257	0.0005282	52.0	COG0457@1|root,COG0457@2|Bacteria,1G71S@1117|Cyanobacteria,1HHGD@1150|Oscillatoriales	1117|Cyanobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_10,TPR_11,TPR_16,TPR_2,TPR_6,TPR_8
SX2_k127_5262650_5	716928.AJQT01000121_gene5413	1.579e-11	77.0	COG3206@1|root,COG3206@2|Bacteria,1MVBX@1224|Proteobacteria,2TTBW@28211|Alphaproteobacteria,4BC8H@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	protein involved in exopolysaccharide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	GNVR,Wzz
SX2_k127_5262650_6	1479237.JMLY01000001_gene1821	6.295e-11	73.0	COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,1RQSM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	polysaccharide export	wza	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
SX2_k127_5262650_1	1379698.RBG1_1C00001G1329	2.588e-71	254.0	COG2199@1|root,COG3706@2|Bacteria,2NPJ3@2323|unclassified Bacteria	2|Bacteria	T	diguanylate cyclase	-	-	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GAF_2,GGDEF,PAS_4,PAS_9,PocR,Response_reg
SX2_k127_5266682_4	767817.Desgi_2589	1.213e-50	188.0	COG0455@1|root,COG0455@2|Bacteria,1V1FH@1239|Firmicutes,24DP7@186801|Clostridia,2628E@186807|Peptococcaceae	186801|Clostridia	D	bacterial-type flagellum organization	-	-	-	-	-	-	-	-	-	-	-	-	CbiA
SX2_k127_5266682_6	1054217.TALC_00346	5.292e-18	86.0	COG1146@1|root,arCOG00959@2157|Archaea	2157|Archaea	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	korD	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7
SX2_k127_5266682_0	1121405.dsmv_1449	1.371e-140	455.0	COG0674@1|root,COG0674@2|Bacteria,1MWCI@1224|Proteobacteria,42NJY@68525|delta/epsilon subdivisions,2WIW3@28221|Deltaproteobacteria,2MHPN@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	vorA	-	1.2.7.11,1.2.7.3,1.2.7.7	ko:K00174,ko:K00186	ko00010,ko00020,ko00280,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197,R07160,R08566,R08567	RC00004,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1307	PFOR_II,POR_N
SX2_k127_5266682_1	177437.HRM2_10700	9.18e-90	301.0	COG1013@1|root,COG1013@2|Bacteria,1N0HY@1224|Proteobacteria,42MTM@68525|delta/epsilon subdivisions,2WJS6@28221|Deltaproteobacteria,2MIRW@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
SX2_k127_5266682_7	1121428.DESHY_60117___1	8.119e-18	89.0	COG1013@1|root,COG1013@2|Bacteria,1UZ67@1239|Firmicutes,247Q7@186801|Clostridia,2613R@186807|Peptococcaceae	186801|Clostridia	C	PFAM Thiamine pyrophosphate	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
SX2_k127_5266682_3	1232437.KL661988_gene237	9.698e-55	197.0	COG1014@1|root,COG1014@2|Bacteria,1R92Y@1224|Proteobacteria,42QJI@68525|delta/epsilon subdivisions,2WMFZ@28221|Deltaproteobacteria,2MJ4M@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM 2-oxoacid acceptor oxidoreductase, gamma subunit, pyruvate 2-ketoisovalerate family	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
SX2_k127_5266682_5	945713.IALB_0529	1.218e-41	158.0	COG1905@1|root,COG1905@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
SX2_k127_5266682_2	311424.DhcVS_635	2.165e-76	263.0	COG1894@1|root,COG1894@2|Bacteria,2G5K9@200795|Chloroflexi,34D48@301297|Dehalococcoidia	301297|Dehalococcoidia	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
SX2_k127_5281504_0	1379698.RBG1_1C00001G1092	1.269e-174	565.0	COG2866@1|root,COG4412@1|root,COG2866@2|Bacteria,COG4412@2|Bacteria,2NPI7@2323|unclassified Bacteria	2|Bacteria	E	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	3.4.17.18,3.4.17.22	ko:K05996,ko:K07752	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	F5_F8_type_C,Peptidase_M14,Peptidase_M6,Ricin_B_lectin,fn3
SX2_k127_5281504_1	1379698.RBG1_1C00001G1199	2.178e-73	267.0	COG3852@1|root,COG3852@2|Bacteria,2NS4D@2323|unclassified Bacteria	2|Bacteria	T	Signal transduction histidine kinase, nitrogen specific, NtrB	-	-	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_9
SX2_k127_5300204_2	1379698.RBG1_1C00001G1043	1.139e-17	85.0	COG0859@1|root,COG0859@2|Bacteria,2NP5P@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferase, family 9	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
SX2_k127_5300204_0	580340.Tlie_1235	1.039e-40	157.0	COG0241@1|root,COG0241@2|Bacteria,3TB5N@508458|Synergistetes	508458|Synergistetes	E	1,7-bisphosphate phosphatase	-	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_like
SX2_k127_5300204_1	523850.TON_0415	8.257e-38	144.0	COG1180@1|root,arCOG00946@2157|Archaea,2XUB7@28890|Euryarchaeota,242R9@183968|Thermococci	183968|Thermococci	O	4Fe-4S single cluster domain	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
SX2_k127_5327303_1	1379698.RBG1_1C00001G0260	9.219e-74	257.0	COG0706@1|root,COG0706@2|Bacteria,2NP6C@2323|unclassified Bacteria	2|Bacteria	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0031224,GO:0031226,GO:0032940,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051205,GO:0051234,GO:0051259,GO:0051260,GO:0051641,GO:0061024,GO:0065003,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
SX2_k127_5327303_0	992406.RIA_0028	2.22e-91	318.0	COG0486@1|root,COG0486@2|Bacteria,4NECT@976|Bacteroidetes,1HWWM@117743|Flavobacteriia	976|Bacteroidetes	S	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
SX2_k127_5331645_1	945713.IALB_1439	9.748e-35	133.0	COG0016@1|root,COG0016@2|Bacteria	2|Bacteria	J	phenylalanine-tRNA ligase activity	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
SX2_k127_5331645_0	1379698.RBG1_1C00001G1120	4.46e-109	364.0	COG0072@1|root,COG0072@2|Bacteria,2NNXI@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iG2583_1286.G2583_2160,iPC815.YPO2428	B3_4,B5,FDX-ACB,tRNA_bind
SX2_k127_5339463_0	264732.Moth_1709	2.397e-94	317.0	COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,247QC@186801|Clostridia,42FBT@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
SX2_k127_5339463_1	1267533.KB906733_gene3415	4.472e-08	63.0	COG0457@1|root,COG0457@2|Bacteria,3Y35N@57723|Acidobacteria,2JHIM@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
SX2_k127_5340764_1	1379698.RBG1_1C00001G0989	6.478e-38	154.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS,Nfu_N,Virulence_fact
SX2_k127_5340764_0	1379698.RBG1_1C00001G0990	8.476e-63	231.0	COG3359@1|root,COG3359@2|Bacteria,2NPCP@2323|unclassified Bacteria	2|Bacteria	L	RNase_H superfamily	yprB	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
SX2_k127_5340764_2	316067.Geob_3831	1.637e-35	151.0	COG1639@1|root,COG1639@2|Bacteria,1RAH3@1224|Proteobacteria,42PRF@68525|delta/epsilon subdivisions,2WQQK@28221|Deltaproteobacteria,43UEV@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Metal-dependent phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
SX2_k127_5357637_1	1379698.RBG1_1C00001G1496	2.13e-53	194.0	COG2065@1|root,COG2065@2|Bacteria,2NPF2@2323|unclassified Bacteria	2|Bacteria	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
SX2_k127_5357637_0	1379698.RBG1_1C00001G1495	5.521e-81	274.0	COG0540@1|root,COG0540@2|Bacteria,2NNPZ@2323|unclassified Bacteria	2|Bacteria	F	Belongs to the ATCase OTCase family	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00608,ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU15490	OTCace,OTCace_N
SX2_k127_5375707_0	246969.TAM4_288	3.841e-133	435.0	COG1350@1|root,arCOG01432@2157|Archaea,2Y845@28890|Euryarchaeota,2438I@183968|Thermococci	183968|Thermococci	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SX2_k127_5375707_2	391603.FBALC1_03532	2.371e-24	106.0	COG1917@1|root,COG1917@2|Bacteria,4NRR5@976|Bacteroidetes,1I3Q8@117743|Flavobacteriia	976|Bacteroidetes	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SX2_k127_5375707_3	927658.AJUM01000042_gene1640	4.251e-20	95.0	COG4309@1|root,COG4309@2|Bacteria,4NQP0@976|Bacteroidetes,2FUI1@200643|Bacteroidia,3XKFI@558415|Marinilabiliaceae	976|Bacteroidetes	S	Domain of unknown function (DUF1858)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858,DUF2249
SX2_k127_5375707_1	927658.AJUM01000042_gene1639	1.11e-78	268.0	COG2461@1|root,COG2461@2|Bacteria,4NJQA@976|Bacteroidetes,2FMK7@200643|Bacteroidia,3XKFV@558415|Marinilabiliaceae	976|Bacteroidetes	S	PAS domain	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF1858,DUF438,Hemerythrin,PAS_10
SX2_k127_5375886_1	879310.HMPREF9162_0476	6.179e-06	55.0	2E382@1|root,32Y7S@2|Bacteria,1VF4Z@1239|Firmicutes,4H5V7@909932|Negativicutes	909932|Negativicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5375886_0	1379698.RBG1_1C00001G0456	5.992e-69	252.0	COG0760@1|root,COG0760@2|Bacteria,2NP7B@2323|unclassified Bacteria	2|Bacteria	O	Peptidylprolyl isomerase	ppiD	-	5.2.1.8	ko:K01802,ko:K03769,ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_2,SurA_N_3
SX2_k127_5380527_1	1219049.SP5_025_00370	4.673e-21	102.0	COG0693@1|root,COG0693@2|Bacteria,1MY0C@1224|Proteobacteria,2U5BS@28211|Alphaproteobacteria,2K4S9@204457|Sphingomonadales	204457|Sphingomonadales	S	DJ-1/PfpI family	-	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
SX2_k127_5380527_0	452637.Oter_1872	8.02e-47	183.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SX2_k127_5380527_3	1246995.AFR_19680	1.685e-05	57.0	COG3631@1|root,COG3631@2|Bacteria,2IHXY@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,SnoaL_3
SX2_k127_5380527_2	172088.AUGA01000004_gene3973	1.003e-05	51.0	COG0454@1|root,COG0454@2|Bacteria,1MVVG@1224|Proteobacteria,2TR1B@28211|Alphaproteobacteria,3JTVI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
SX2_k127_5391593_1	1379698.RBG1_1C00001G1369	2.939e-11	65.0	COG4219@1|root,COG4219@2|Bacteria,2NR11@2323|unclassified Bacteria	2|Bacteria	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_6,DUF4309,DUF5301
SX2_k127_5391593_0	555779.Dthio_PD1816	5.9e-55	203.0	COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,42TGK@68525|delta/epsilon subdivisions,2WNGS@28221|Deltaproteobacteria,2MGTS@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Serine aminopeptidase, S33	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Hydrolase_4
SX2_k127_5391593_2	1191523.MROS_2413	1.971e-06	57.0	2CG1Y@1|root,2Z9QX@2|Bacteria	2|Bacteria	S	COG NOG19146 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	DUF1573
SX2_k127_5391593_3	1379698.RBG1_1C00001G1104	0.0005679	45.0	2B0A3@1|root,31SM2@2|Bacteria,2NRWJ@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function (DUF1573)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1573
SX2_k127_5392029_0	1304874.JAFY01000002_gene767	1.748e-24	113.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	ko:K10709	-	-	-	-	ko00000	-	-	-	AP_endonuc_2
SX2_k127_5392029_1	335543.Sfum_1397	5.667e-19	91.0	COG1917@1|root,COG1917@2|Bacteria,1N2JS@1224|Proteobacteria,42TR3@68525|delta/epsilon subdivisions,2WQ4M@28221|Deltaproteobacteria,2MSCX@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SX2_k127_5407280_0	1379698.RBG1_1C00001G1445	3.278e-123	405.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,2NQSG@2323|unclassified Bacteria	2|Bacteria	MU	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641,ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33,2.C.1.2	-	-	BSP,Bac_surface_Ag,PD40,Peptidase_MA_2
SX2_k127_5413686_3	218495.SUB1520	6.156e-36	143.0	COG1806@1|root,COG1806@2|Bacteria,1TPG0@1239|Firmicutes,4HB0Q@91061|Bacilli	91061|Bacilli	S	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation	yqfL	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
SX2_k127_5413686_2	1379698.RBG1_1C00001G1318	2.188e-76	269.0	COG0392@1|root,COG0392@2|Bacteria,2NPGZ@2323|unclassified Bacteria	2|Bacteria	S	Lysylphosphatidylglycerol synthase TM region	mprF	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
SX2_k127_5413686_1	1379698.RBG1_1C00001G1319	1.892e-128	421.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
SX2_k127_5413686_0	1379698.RBG1_1C00001G0356	2.379e-176	583.0	COG0457@1|root,COG0697@1|root,COG0457@2|Bacteria,COG0697@2|Bacteria,2NS3S@2323|unclassified Bacteria	2|Bacteria	EG	Protein of unknown function (DUF2723)	-	-	-	ko:K16928	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.33	-	-	DUF2723,QueT
SX2_k127_5413686_4	1499967.BAYZ01000156_gene556	1.644e-18	86.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568,ko:K20444	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_trans_1_4,Glycos_transf_2,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
SX2_k127_5420038_0	1379698.RBG1_1C00001G0950	1.378e-73	255.0	COG0336@1|root,COG0336@2|Bacteria,2NP5G@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0000287,GO:0001510,GO:0002939,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050518,GO:0052906,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228,4.6.1.12	ko:K00554,ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R00597,R05637	RC00002,RC00003,RC00334,RC01440	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	tRNA_m1G_MT
SX2_k127_5420038_3	264732.Moth_0971	1.254e-34	135.0	COG0335@1|root,COG0335@2|Bacteria,1V6FT@1239|Firmicutes,24J83@186801|Clostridia,42GJ8@68295|Thermoanaerobacterales	186801|Clostridia	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
SX2_k127_5420038_2	515635.Dtur_1531	5.263e-51	188.0	COG0164@1|root,COG0164@2|Bacteria	2|Bacteria	L	RNA-DNA hybrid ribonuclease activity	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
SX2_k127_5420038_6	290512.Paes_0016	1.265e-14	78.0	COG0792@1|root,COG0792@2|Bacteria,1FE8E@1090|Chlorobi	1090|Chlorobi	J	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
SX2_k127_5420038_5	1183438.GKIL_0191	1.559e-32	144.0	COG1293@1|root,COG1293@2|Bacteria,1G01H@1117|Cyanobacteria	1117|Cyanobacteria	K	RNA-binding protein homologous to eukaryotic snRNP	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
SX2_k127_5420038_1	1379698.RBG1_1C00001G0958	2.314e-63	228.0	COG1561@1|root,COG1561@2|Bacteria,2NPG5@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF1732)	yicC	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	DUF1732,YicC_N
SX2_k127_5420038_4	1540257.JQMW01000009_gene3624	1.153e-32	131.0	COG0194@1|root,COG0194@2|Bacteria,1TP0M@1239|Firmicutes,24HEX@186801|Clostridia,36EVE@31979|Clostridiaceae	186801|Clostridia	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
SX2_k127_5440649_0	517418.Ctha_1137	1.524e-31	142.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,PSII_BNR,Sortilin-Vps10
SX2_k127_5447991_0	1536774.H70357_21435	1.796e-18	95.0	COG0455@1|root,COG0455@2|Bacteria,1TRZ5@1239|Firmicutes,4HCWZ@91061|Bacilli,26R9C@186822|Paenibacillaceae	91061|Bacilli	D	Belongs to the ParA family	ylxH	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	AAA_31,CbiA,ParA
SX2_k127_5447991_1	1280664.AUIX01000003_gene133	1.439e-16	89.0	COG1419@1|root,COG1419@2|Bacteria,1TSP7@1239|Firmicutes,249R1@186801|Clostridia,4BWKI@830|Butyrivibrio	186801|Clostridia	N	SRP54-type protein, GTPase domain	flhF	-	-	ko:K02404	-	-	-	-	ko00000,ko02035	-	-	-	SRP54
SX2_k127_5453140_4	1300345.LF41_23	0.0004585	44.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,1RNY5@1236|Gammaproteobacteria,1X31X@135614|Xanthomonadales	135614|Xanthomonadales	C	Electron transfer flavoprotein-ubiquinone oxidoreductase	etf-QO	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO,FAD_binding_2,NAD_binding_8,Thi4
SX2_k127_5453140_3	1121355.KB903379_gene745	1.359e-05	48.0	COG0544@1|root,COG0544@2|Bacteria,2GJIG@201174|Actinobacteria,22JV9@1653|Corynebacteriaceae	201174|Actinobacteria	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
SX2_k127_5453140_0	1379698.RBG1_1C00001G1098	2.973e-40	153.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	spo0A	-	-	ko:K03413,ko:K07699	ko02020,ko02024,ko02030,map02020,map02024,map02030	M00485,M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg,Spo0A_C
SX2_k127_5453140_2	404589.Anae109_0975	2.445e-13	78.0	COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,42WB9@68525|delta/epsilon subdivisions,2WSSJ@28221|Deltaproteobacteria,2YVJB@29|Myxococcales	28221|Deltaproteobacteria	S	PHB/PHA accumulation regulator DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PHB_acc_N
SX2_k127_5453140_1	243090.RB5336	3.441e-20	96.0	COG2146@1|root,COG2146@2|Bacteria,2J0FX@203682|Planctomycetes	203682|Planctomycetes	P	COG2146 Ferredoxin subunits of nitrite reductase and	-	-	1.7.1.15	ko:K00363,ko:K05710	ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220	M00530,M00545	R00787,R06782,R06783	RC00098,RC00176	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske
SX2_k127_545673_5	1379698.RBG1_1C00001G0145	1.079e-13	76.0	2EPKR@1|root,33H7C@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_545673_4	1379698.RBG1_1C00001G0144	1.933e-18	87.0	2EQQP@1|root,33IAK@2|Bacteria	2|Bacteria	S	Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter	-	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATPase_gene1
SX2_k127_545673_2	1379698.RBG1_1C00001G1740	5.058e-131	439.0	COG3852@1|root,COG3852@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_8,PAS_9
SX2_k127_545673_1	1379698.RBG1_1C00001G1741	5.364e-173	550.0	COG1459@1|root,COG1459@2|Bacteria,2NP2J@2323|unclassified Bacteria	2|Bacteria	U	Type II secretion system (T2SS), protein F	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
SX2_k127_545673_0	1379698.RBG1_1C00001G1742	2.464e-174	552.0	COG2805@1|root,COG2805@2|Bacteria,2NNR7@2323|unclassified Bacteria	2|Bacteria	NU	Type II/IV secretion system protein	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
SX2_k127_545673_3	1379698.RBG1_1C00001G1743	3.249e-27	113.0	COG2804@1|root,COG2804@2|Bacteria,2NNNI@2323|unclassified Bacteria	2|Bacteria	NU	Type II secretion system (T2SS), protein E, N-terminal domain	pilB	-	-	ko:K02454,ko:K02504,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
SX2_k127_546170_0	240015.ACP_3156	5.342e-30	133.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,3Y34Y@57723|Acidobacteria,2JHQ9@204432|Acidobacteriia	204432|Acidobacteriia	C	Dehydrogenase E1 component	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
SX2_k127_5465959_0	330214.NIDE1358	4.974e-70	247.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,3J0EB@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
SX2_k127_5465959_1	404589.Anae109_1277	3.25e-27	115.0	COG1959@1|root,COG1959@2|Bacteria,1Q19C@1224|Proteobacteria,4375I@68525|delta/epsilon subdivisions,2WRDB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
SX2_k127_5492357_1	1379698.RBG1_1C00001G0753	1.943e-105	353.0	COG0430@1|root,COG0430@2|Bacteria,2NP9K@2323|unclassified Bacteria	2|Bacteria	A	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	GO:0003674,GO:0003824,GO:0003963,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009975,GO:0016874,GO:0016886,GO:0044424,GO:0044464,GO:0140098	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
SX2_k127_5492357_0	251229.Chro_4403	1.106e-287	902.0	COG0068@1|root,COG0068@2|Bacteria,1G063@1117|Cyanobacteria,3VI6E@52604|Pleurocapsales	1117|Cyanobacteria	O	PFAM HypF finger	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
SX2_k127_5492357_2	497965.Cyan7822_0631	7.299e-27	116.0	COG0298@1|root,COG0298@2|Bacteria,1G9FZ@1117|Cyanobacteria,3KIER@43988|Cyanothece	1117|Cyanobacteria	O	PFAM hydrogenase expression formation protein (HUPF HYPC)	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
SX2_k127_5492357_3	518766.Rmar_2595	1.918e-18	85.0	COG0409@1|root,COG0409@2|Bacteria,4NIM8@976|Bacteroidetes	976|Bacteroidetes	O	TIGRFAM hydrogenase expression formation protein HypD	-	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
SX2_k127_5499398_1	379066.GAU_1615	4.1e-11	67.0	COG0438@1|root,COG0438@2|Bacteria,1ZSTJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SX2_k127_5499398_0	1379698.RBG1_1C00001G1315	6.781e-69	249.0	COG0463@1|root,COG0463@2|Bacteria,2NP2G@2323|unclassified Bacteria	2|Bacteria	M	Glycosyltransferase like family 2	arnC	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
SX2_k127_5499398_2	1267535.KB906767_gene296	2.653e-06	55.0	COG0457@1|root,COG0457@2|Bacteria,3Y4S2@57723|Acidobacteria	57723|Acidobacteria	NU	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_8
SX2_k127_5500580_0	1379698.RBG1_1C00001G0864	6.64e-176	585.0	COG1452@1|root,COG1452@2|Bacteria,2NPN2@2323|unclassified Bacteria	2|Bacteria	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	-	-	-	ko:K04744,ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptC,OstA,OstA_C
SX2_k127_5525914_1	1121920.AUAU01000006_gene269	7.312e-50	188.0	COG1305@1|root,COG1305@2|Bacteria	2|Bacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	7TM_transglut,NTP_transf_5,Transglut_core,Transglut_core3
SX2_k127_5525914_0	204669.Acid345_4043	1.612e-84	296.0	COG1680@1|root,COG1680@2|Bacteria,3Y7SG@57723|Acidobacteria,2JMWV@204432|Acidobacteriia	204432|Acidobacteriia	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SX2_k127_5527727_2	316067.Geob_3422	1.698e-60	214.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,42MMY@68525|delta/epsilon subdivisions,2WIXA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15,2.7.6.3	ko:K00796,ko:K13941	ko00790,ko01100,map00790,map01100	M00126,M00840,M00841	R03066,R03067,R03503	RC00002,RC00017,RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
SX2_k127_5527727_1	1033743.CAES01000084_gene3070	5.587e-62	222.0	COG1624@1|root,COG1624@2|Bacteria,1TPRW@1239|Firmicutes,4H9XZ@91061|Bacilli,26R2I@186822|Paenibacillaceae	91061|Bacilli	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009975,GO:0016020,GO:0016021,GO:0016829,GO:0016849,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
SX2_k127_5527727_0	880073.Calab_0862	4.97e-109	366.0	COG1322@1|root,COG1322@2|Bacteria,2NPXU@2323|unclassified Bacteria	2|Bacteria	S	RmuC family	-	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
SX2_k127_5530946_0	335543.Sfum_2158	6.001e-14	80.0	COG3391@1|root,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,42RMY@68525|delta/epsilon subdivisions,2WNJD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
SX2_k127_5535183_0	269799.Gmet_3460	1.155e-99	338.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,42NC3@68525|delta/epsilon subdivisions,2WIJJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
SX2_k127_5543736_1	391625.PPSIR1_30539	1.008e-14	75.0	COG0312@1|root,COG0312@2|Bacteria,1Q3C0@1224|Proteobacteria,4393A@68525|delta/epsilon subdivisions,2X495@28221|Deltaproteobacteria,2YYIX@29|Myxococcales	28221|Deltaproteobacteria	S	peptidase U62 modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
SX2_k127_5543736_0	234267.Acid_5820	4.8e-69	254.0	COG0312@1|root,COG0312@2|Bacteria,3Y686@57723|Acidobacteria	57723|Acidobacteria	S	Putative modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
SX2_k127_5553597_1	330214.NIDE2489	5.05e-53	197.0	28MEN@1|root,2ZASA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5553597_3	1379698.RBG1_1C00001G0114	1.149e-33	140.0	29ZH8@1|root,30MGZ@2|Bacteria,2NQ83@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5553597_0	671143.DAMO_0350	4.352e-53	198.0	28MYQ@1|root,2ZB5K@2|Bacteria,2NPC8@2323|unclassified Bacteria	2|Bacteria	S	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5553597_2	671143.DAMO_0351	2.65e-44	168.0	2ANS9@1|root,31DS7@2|Bacteria,2NQ66@2323|unclassified Bacteria	2|Bacteria	S	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5561232_1	1379698.RBG1_1C00001G1726	1.149e-09	68.0	29YZ1@1|root,30KVZ@2|Bacteria,2NRNQ@2323|unclassified Bacteria	2|Bacteria	S	Capsule assembly protein Wzi	-	-	-	-	-	-	-	-	-	-	-	-	Caps_assemb_Wzi
SX2_k127_5561232_0	880073.Calab_3076	9.543e-118	406.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,2NNKC@2323|unclassified Bacteria	2|Bacteria	M	Tricorn protease C1 domain	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,PDZ,PDZ_2,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
SX2_k127_5567299_0	1209072.ALBT01000006_gene785	4.474e-13	72.0	COG0330@1|root,COG0330@2|Bacteria,1P8ZI@1224|Proteobacteria,1RUQU@1236|Gammaproteobacteria,1FI0E@10|Cellvibrio	1236|Gammaproteobacteria	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
SX2_k127_5567299_1	794903.OPIT5_06830	1.927e-06	61.0	COG2834@1|root,COG2834@2|Bacteria,46YSI@74201|Verrucomicrobia,3K9A7@414999|Opitutae	414999|Opitutae	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5592698_0	1123376.AUIU01000015_gene485	4.661e-46	183.0	COG2203@1|root,COG3829@1|root,COG3852@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,COG3852@2|Bacteria,3J0YT@40117|Nitrospirae	40117|Nitrospirae	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_9
SX2_k127_5602661_0	1379698.RBG1_1C00001G0450	3.536e-168	538.0	COG1190@1|root,COG1190@2|Bacteria,2NNMH@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006518,GO:0006520,GO:0006629,GO:0006644,GO:0006650,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009059,GO:0009405,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019637,GO:0019752,GO:0030312,GO:0030322,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0042221,GO:0042391,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046471,GO:0046483,GO:0046486,GO:0046677,GO:0046872,GO:0050896,GO:0051704,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.6	ko:K04567,ko:K04568	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03012,ko03016	-	-	iAF1260.b4129,iECDH1ME8569_1439.ECDH1ME8569_3989,iECW_1372.ECW_m4490,iEcDH1_1363.EcDH1_3862,iJN678.lysS,iJO1366.b4129,iWFL_1372.ECW_m4490	DUF2156,tRNA-synt_2,tRNA-synt_2_TM,tRNA_anti-codon
SX2_k127_5602661_1	1379698.RBG1_1C00001G0449	1.076e-22	103.0	COG4591@1|root,COG4591@2|Bacteria,2NP18@2323|unclassified Bacteria	2|Bacteria	M	ABC-type transport system involved in lipoprotein release permease component	lolC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008104,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0034613,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0098796,GO:0098797,GO:1990778	-	ko:K02004,ko:K09808	ko02010,map02010	M00255,M00258	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.125	-	-	FtsX,MacB_PCD
SX2_k127_5625184_3	443143.GM18_2643	3.419e-22	102.0	COG2984@1|root,COG2984@2|Bacteria,1Q1HH@1224|Proteobacteria,42UE1@68525|delta/epsilon subdivisions,2WR33@28221|Deltaproteobacteria,43VBE@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
SX2_k127_5625184_0	1499967.BAYZ01000017_gene6227	1.316e-69	257.0	COG4191@1|root,COG4191@2|Bacteria,2NP7Y@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HAMP,HATPase_c,HisKA
SX2_k127_5625184_2	880073.Calab_2186	8.042e-23	102.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
SX2_k127_5625184_4	272558.10176412	1.629e-18	91.0	COG2204@1|root,COG2204@2|Bacteria,1V6R9@1239|Firmicutes,4HIXH@91061|Bacilli,1ZG9M@1386|Bacillus	91061|Bacilli	T	response regulator	spo0F	-	-	ko:K02490	ko02020,ko02024,map02020,map02024	M00485	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
SX2_k127_5625184_1	1379698.RBG1_1C00001G1290	6.798e-46	184.0	COG2204@1|root,COG3852@1|root,COG2204@2|Bacteria,COG3852@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	ppsR	-	2.7.13.3	ko:K03413,ko:K07708	ko02020,ko02030,map02020,map02030	M00497,M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HTH_8,PAS,PAS_4,PAS_8,PAS_9,Response_reg
SX2_k127_5633872_7	411490.ANACAC_00226	5.058e-39	152.0	COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,248HD@186801|Clostridia	186801|Clostridia	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
SX2_k127_5633872_2	1379698.RBG1_1C00001G0481	1.129e-76	264.0	COG1716@1|root,COG1716@2|Bacteria,2NQ4X@2323|unclassified Bacteria	2|Bacteria	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3662,DUF4388,FHA,Yop-YscD_cpl
SX2_k127_5633872_3	1379698.RBG1_1C00001G0480	1.272e-65	231.0	COG0639@1|root,COG0639@2|Bacteria,2NPHT@2323|unclassified Bacteria	2|Bacteria	T	Calcineurin-like phosphoesterase superfamily domain	apaH	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
SX2_k127_5633872_0	1379698.RBG1_1C00001G0479	1.028e-150	509.0	COG0515@1|root,COG0515@2|Bacteria	1379698.RBG1_1C00001G0479|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5633872_6	1379698.RBG1_1C00001G1804	2.641e-47	173.0	2E8AI@1|root,332PD@2|Bacteria,2NRHQ@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5633872_10	1379698.RBG1_1C00001G1805	1.569e-15	78.0	COG1826@1|root,COG1826@2|Bacteria,2NQ3N@2323|unclassified Bacteria	2|Bacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
SX2_k127_5633872_1	1379698.RBG1_1C00001G1807	9.203e-103	338.0	COG0047@1|root,COG0047@2|Bacteria,2NP46@2323|unclassified Bacteria	2|Bacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	GO:0003674,GO:0003824,GO:0004642,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
SX2_k127_5633872_9	351016.RAZWK3B_16525	2.369e-16	81.0	COG1828@1|root,COG1828@2|Bacteria,1N83G@1224|Proteobacteria,2UF7S@28211|Alphaproteobacteria,2P3KU@2433|Roseobacter	28211|Alphaproteobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
SX2_k127_5633872_4	1379698.RBG1_1C00001G1809	3.992e-63	225.0	COG1183@1|root,COG1183@2|Bacteria,2NPQM@2323|unclassified Bacteria	2|Bacteria	I	CDP-alcohol phosphatidyltransferase	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
SX2_k127_5633872_5	290512.Paes_0540	1.409e-48	180.0	COG0688@1|root,COG0688@2|Bacteria,1FDXU@1090|Chlorobi	1090|Chlorobi	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
SX2_k127_5644840_4	1379698.RBG1_1C00001G1358	3.83e-30	129.0	COG0810@1|root,COG0810@2|Bacteria,2NQ1D@2323|unclassified Bacteria	2|Bacteria	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	CarbopepD_reg_2,TonB_C
SX2_k127_5644840_2	1379698.RBG1_1C00001G1358	4.722e-41	161.0	COG0810@1|root,COG0810@2|Bacteria,2NQ1D@2323|unclassified Bacteria	2|Bacteria	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	CarbopepD_reg_2,TonB_C
SX2_k127_5644840_3	1379698.RBG1_1C00001G1357	6.855e-40	155.0	COG0848@1|root,COG0848@2|Bacteria	2|Bacteria	U	biopolymer transport protein	exbD2	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
SX2_k127_5644840_1	1379698.RBG1_1C00001G1356	1.595e-48	180.0	COG0848@1|root,COG0848@2|Bacteria	2|Bacteria	U	biopolymer transport protein	exbD1	-	-	-	-	-	-	-	-	-	-	-	ExbD
SX2_k127_5644840_0	1379698.RBG1_1C00001G1355	2.39e-78	269.0	COG0811@1|root,COG0811@2|Bacteria,2NPUZ@2323|unclassified Bacteria	2|Bacteria	U	MotA/TolQ/ExbB proton channel family	exbB	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
SX2_k127_5644840_6	10228.TriadP24608	0.0009175	51.0	COG0457@1|root,COG3914@1|root,KOG1124@2759|Eukaryota,KOG4626@2759|Eukaryota,38DM6@33154|Opisthokonta,3BEU3@33208|Metazoa	33208|Metazoa	O	TeTratriCopeptide repeat	TTC6	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
SX2_k127_565759_0	7739.XP_002595557.1	1.455e-12	81.0	COG0457@1|root,KOG0548@2759|Eukaryota	2759|Eukaryota	J	positive regulation of catalytic activity in other organism involved in symbiotic interaction	-	-	-	ko:K14861	-	-	-	-	ko00000,ko03009	-	-	-	DUF294,TPR_10,TPR_12,TPR_7,TPR_8
SX2_k127_5661603_2	468059.AUHA01000002_gene971	0.0002035	46.0	COG0457@1|root,COG1680@1|root,COG0457@2|Bacteria,COG1680@2|Bacteria,4NFSI@976|Bacteroidetes,1IVKH@117747|Sphingobacteriia	976|Bacteroidetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,TPR_8
SX2_k127_5661603_1	865861.AZSU01000002_gene2982	1.605e-25	119.0	COG2348@1|root,COG2348@2|Bacteria,1US0N@1239|Firmicutes,24Y76@186801|Clostridia,36QAM@31979|Clostridiaceae	186801|Clostridia	V	transferase activity, transferring amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5661603_0	931276.Cspa_c19750	1.967e-80	275.0	COG0451@1|root,COG0451@2|Bacteria,1VP6I@1239|Firmicutes,251A8@186801|Clostridia,36G9M@31979|Clostridiaceae	186801|Clostridia	GM	Male sterility protein	-	-	4.2.1.46,5.1.3.2	ko:K01710,ko:K01784	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R02984,R06513	RC00289,RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
SX2_k127_566558_0	1379698.RBG1_1C00001G1334	2.55e-23	112.0	COG2067@1|root,COG2067@2|Bacteria,2NQKU@2323|unclassified Bacteria	2|Bacteria	I	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2
SX2_k127_5675228_0	1379698.RBG1_1C00001G0158	1.472e-196	636.0	COG0642@1|root,COG2204@1|root,COG2204@2|Bacteria,COG2205@2|Bacteria,2NPIU@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Response_reg
SX2_k127_5675228_2	1379698.RBG1_1C00001G0157	4.268e-99	339.0	COG0642@1|root,COG2205@2|Bacteria	1379698.RBG1_1C00001G0157|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5675228_3	1379698.RBG1_1C00001G1550	3.158e-98	336.0	COG0285@1|root,COG0285@2|Bacteria,2NP60@2323|unclassified Bacteria	2|Bacteria	H	Belongs to the folylpolyglutamate synthase family	folC	GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM0166,iSB619.SA_RS08370	Mur_ligase_C,Mur_ligase_M
SX2_k127_5675228_1	1379698.RBG1_1C00001G1549	4.878e-123	401.0	COG0777@1|root,COG0777@2|Bacteria,2NP40@2323|unclassified Bacteria	2|Bacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	GO:0001676,GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003729,GO:0003824,GO:0003989,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006417,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0017148,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032787,GO:0032991,GO:0034248,GO:0034249,GO:0042759,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:0097159,GO:1901363,GO:1901576,GO:1902494,GO:1990234,GO:2000112,GO:2000113	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.accD,iPC815.YPO2768,iUTI89_1310.UTI89_C2601	Carboxyl_trans
SX2_k127_5675228_4	658655.HMPREF0988_03149	5.898e-38	156.0	COG0454@1|root,COG1214@1|root,COG0456@2|Bacteria,COG1214@2|Bacteria,1V4YX@1239|Firmicutes,24A0P@186801|Clostridia,27IG5@186928|unclassified Lachnospiraceae	186801|Clostridia	O	Glycoprotease family	yeaZ	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Acetyltransf_1,Peptidase_M22
SX2_k127_5675228_5	401526.TcarDRAFT_0377	1.86e-24	106.0	COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,4H4ZR@909932|Negativicutes	909932|Negativicutes	S	Hydrolase, P-loop family	yjeE	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
SX2_k127_5675854_0	237368.SCABRO_03415	3.198e-31	130.0	COG0365@1|root,COG0365@2|Bacteria,2IX5P@203682|Planctomycetes	203682|Planctomycetes	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
SX2_k127_5675854_1	497965.Cyan7822_3969	2.217e-29	121.0	COG0122@1|root,COG0122@2|Bacteria,1G394@1117|Cyanobacteria,3KHNH@43988|Cyanothece	1117|Cyanobacteria	L	PFAM HhH-GPD family protein	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
SX2_k127_568569_5	555079.Toce_2009	0.0002845	49.0	COG3951@1|root,COG3951@2|Bacteria,1VFX2@1239|Firmicutes,24RKJ@186801|Clostridia,42HMF@68295|Thermoanaerobacterales	186801|Clostridia	N	Rod binding protein	flgJ	-	-	ko:K02395	-	-	-	-	ko00000,ko02035	-	-	-	Rod-binding
SX2_k127_568569_1	933262.AXAM01000005_gene2494	4.858e-90	309.0	COG1706@1|root,COG1706@2|Bacteria,1MVKW@1224|Proteobacteria,42MAU@68525|delta/epsilon subdivisions,2WK22@28221|Deltaproteobacteria,2MI2Y@213118|Desulfobacterales	28221|Deltaproteobacteria	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgI	-	-	ko:K02394	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgI
SX2_k127_568569_2	1313304.CALK_0154	7.198e-35	141.0	COG2063@1|root,COG2063@2|Bacteria	2|Bacteria	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgH	-	-	ko:K01991,ko:K02393	ko02026,ko02040,map02026,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.B.18	-	-	FlgH
SX2_k127_568569_4	667014.Thein_0464	3.06e-08	63.0	COG1261@1|root,COG1261@2|Bacteria,2GHM3@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	NO	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly	-	-	-	ko:K02386	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	ChapFlgA
SX2_k127_568569_0	933262.AXAM01000005_gene2497	1.303e-97	325.0	COG4786@1|root,COG4786@2|Bacteria,1MVMA@1224|Proteobacteria,42N3R@68525|delta/epsilon subdivisions,2WJDN@28221|Deltaproteobacteria,2MIW5@213118|Desulfobacterales	28221|Deltaproteobacteria	N	flagellar basal-body rod protein FlgG	flgG	-	-	ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
SX2_k127_568569_3	404380.Gbem_3763	1.522e-15	79.0	COG4786@1|root,COG4786@2|Bacteria,1PZ24@1224|Proteobacteria,42NGI@68525|delta/epsilon subdivisions,2WMR8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	N	Belongs to the flagella basal body rod proteins family	flgF	-	-	ko:K02391,ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
SX2_k127_5687894_0	1379698.RBG1_1C00001G1218	1.046e-87	304.0	COG0515@1|root,COG0515@2|Bacteria,2NQWH@2323|unclassified Bacteria	2|Bacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_8
SX2_k127_5687894_1	497964.CfE428DRAFT_4330	8.882e-08	61.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	rfaY	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SX2_k127_5695820_2	1027273.GZ77_16825	9.055e-35	137.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,1XH70@135619|Oceanospirillales	135619|Oceanospirillales	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
SX2_k127_5695820_1	1379698.RBG1_1C00001G0400	8.256e-139	451.0	COG0206@1|root,COG0206@2|Bacteria,2NNSU@2323|unclassified Bacteria	2|Bacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0051258,GO:0051301,GO:0065003,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
SX2_k127_5695820_0	546269.HMPREF0389_00564	1.228e-177	565.0	COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,247TU@186801|Clostridia,25QP6@186804|Peptostreptococcaceae	186801|Clostridia	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
SX2_k127_5695820_3	273068.TTE0976	3.496e-13	76.0	COG1381@1|root,COG1381@2|Bacteria,1UZ19@1239|Firmicutes,249TI@186801|Clostridia,42GBN@68295|Thermoanaerobacterales	186801|Clostridia	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
SX2_k127_5700686_2	1192034.CAP_0089	1.511e-13	84.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42RC9@68525|delta/epsilon subdivisions,2WN5U@28221|Deltaproteobacteria,2YWJ8@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
SX2_k127_5700686_0	215803.DB30_0373	8.809e-52	196.0	COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,42QUA@68525|delta/epsilon subdivisions,2WMWM@28221|Deltaproteobacteria,2YU7P@29|Myxococcales	28221|Deltaproteobacteria	T	Protein serine threonine phosphatase	pph1	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
SX2_k127_5700686_1	1379698.RBG1_1C00001G1857	3.692e-41	162.0	COG0795@1|root,COG0795@2|Bacteria,2NPHN@2323|unclassified Bacteria	2|Bacteria	S	Permease YjgP YjgQ	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
SX2_k127_5708091_0	879212.DespoDRAFT_03654	5.965e-120	396.0	COG0577@1|root,COG0577@2|Bacteria,1MWBK@1224|Proteobacteria,42PZC@68525|delta/epsilon subdivisions,2WK59@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX2_k127_5708091_1	316067.Geob_2357	1.707e-105	361.0	COG0577@1|root,COG0577@2|Bacteria,1MX7X@1224|Proteobacteria,42NT4@68525|delta/epsilon subdivisions,2WJFM@28221|Deltaproteobacteria,43T76@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX2_k127_5719130_0	290315.Clim_0129	0.0	1036.0	COG4096@1|root,COG4096@2|Bacteria	2|Bacteria	L	type I site-specific deoxyribonuclease activity	hsdR_2	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	EcoEI_R_C,HSDR_N,HSDR_N_2,Helicase_C,ResIII
SX2_k127_5719130_1	290317.Cpha266_0895	1.675e-245	763.0	COG0286@1|root,COG0732@1|root,COG0286@2|Bacteria,COG0732@2|Bacteria	2|Bacteria	V	type I restriction modification DNA specificity domain	-	-	2.1.1.72,3.1.21.3	ko:K01154,ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,Methylase_S,N6_Mtase
SX2_k127_5755897_0	1379698.RBG1_1C00001G0175	5.212e-61	228.0	COG0845@1|root,COG1994@1|root,COG0845@2|Bacteria,COG1994@2|Bacteria,2NRE7@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02022,ko:K16922,ko:K20345	ko02024,map02024	-	-	-	ko00000,ko00001,ko01002,ko02000	3.A.1.112,8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23,PqqD
SX2_k127_5777757_0	945713.IALB_2321	1.083e-46	181.0	COG0308@1|root,COG0308@2|Bacteria	2|Bacteria	E	peptide catabolic process	pepN1	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
SX2_k127_5784569_1	572265.HDEF_1682	3.39e-11	65.0	28J9D@1|root,2Z94E@2|Bacteria,1QE0C@1224|Proteobacteria,1RZ22@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	P22 coat protein - gene protein 5	-	-	-	-	-	-	-	-	-	-	-	-	P22_CoatProtein
SX2_k127_5794540_0	857293.CAAU_0441	8.446e-77	275.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,36E82@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter transmembrane region	-	-	-	ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
SX2_k127_5794540_1	1379698.RBG1_1C00001G0410	5.548e-55	201.0	COG0750@1|root,COG0750@2|Bacteria,2NP7C@2323|unclassified Bacteria	2|Bacteria	M	zinc metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
SX2_k127_579886_0	1303518.CCALI_02131	1.442e-56	209.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria	2|Bacteria	M	serine-type peptidase activity	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,PDZ,PDZ_2,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
SX2_k127_579886_1	251221.35212645	1.963e-49	188.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	SBBP,TIG,VCBS
SX2_k127_5798897_1	880072.Desac_1866	2.645e-71	247.0	COG0286@1|root,COG0286@2|Bacteria	2|Bacteria	V	site-specific DNA-methyltransferase (adenine-specific) activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA_34,MTS,Methylase_S,N6_Mtase
SX2_k127_5798897_2	880072.Desac_1866	1.076e-37	149.0	COG0286@1|root,COG0286@2|Bacteria	2|Bacteria	V	site-specific DNA-methyltransferase (adenine-specific) activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA_34,MTS,Methylase_S,N6_Mtase
SX2_k127_5798897_0	1379698.RBG1_1C00001G0553	4.038e-133	431.0	COG1493@1|root,COG1493@2|Bacteria,2NP5B@2323|unclassified Bacteria	2|Bacteria	T	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)	hprK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
SX2_k127_5798897_3	379731.PST_1030	4.435e-09	63.0	COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,1S8U1@1236|Gammaproteobacteria,1Z379@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	J	COG1544 Ribosome-associated protein Y (PSrp-1)	yhbH	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosomal_S30AE
SX2_k127_581642_2	1379698.RBG1_1C00001G0383	1.012e-06	54.0	COG0438@1|root,COG0438@2|Bacteria,2NQ17@2323|unclassified Bacteria	2|Bacteria	M	glycosyl transferase group 1	remC	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_2,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
SX2_k127_581642_1	1121957.ATVL01000007_gene2397	3.68e-37	155.0	COG0438@1|root,COG0438@2|Bacteria,4NE6S@976|Bacteroidetes,47P7K@768503|Cytophagia	976|Bacteroidetes	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
SX2_k127_581642_0	1379698.RBG1_1C00001G0386	4.629e-45	172.0	COG1216@1|root,COG1216@2|Bacteria,2NP9Z@2323|unclassified Bacteria	2|Bacteria	GM	Glycosyltransferase like family 2	wbbL	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2
SX2_k127_5824802_2	339671.Asuc_0834	2.844e-26	110.0	COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,1S1Z3@1236|Gammaproteobacteria,1Y8PF@135625|Pasteurellales	135625|Pasteurellales	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
SX2_k127_5824802_1	335543.Sfum_1168	5.738e-56	202.0	COG1014@1|root,COG1014@2|Bacteria,1RAQ4@1224|Proteobacteria,43BEE@68525|delta/epsilon subdivisions,2WN0D@28221|Deltaproteobacteria,2MRMB@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	korC	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
SX2_k127_5824802_0	909663.KI867149_gene3348	1.446e-100	334.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,42MD3@68525|delta/epsilon subdivisions,2WJQ0@28221|Deltaproteobacteria,2MR0N@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	ferredoxin oxidoreductase beta subunit	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
SX2_k127_5824802_3	459349.CLOAM0297	8.457e-14	73.0	COG0674@1|root,COG0674@2|Bacteria,2NNPY@2323|unclassified Bacteria	2|Bacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	oorA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
SX2_k127_5838207_2	1540257.JQMW01000009_gene3557	7.829e-41	157.0	COG0130@1|root,COG0130@2|Bacteria,1TP9Y@1239|Firmicutes,24B46@186801|Clostridia,36EJJ@31979|Clostridiaceae	186801|Clostridia	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
SX2_k127_5838207_1	1379698.RBG1_1C00001G1156	8.508e-63	228.0	COG0618@1|root,COG0618@2|Bacteria,2NPK0@2323|unclassified Bacteria	2|Bacteria	S	DHH family	nrnA	GO:0008150,GO:0040007	2.7.7.72,3.1.13.3,3.1.3.7	ko:K00974,ko:K06881	ko00920,ko01100,ko01120,ko03013,map00920,map01100,map01120,map03013	-	R00188,R00508,R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03400	-	-	-	DHH,DHHA1
SX2_k127_5838207_3	420246.GTNG_1119	5.793e-28	117.0	COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,4HII1@91061|Bacilli,1WGHF@129337|Geobacillus	91061|Bacilli	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
SX2_k127_5838207_4	671143.DAMO_0575	1.541e-20	93.0	COG1550@1|root,COG1550@2|Bacteria,2NPYX@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function (DUF503)	ylxP	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
SX2_k127_5838207_0	1379698.RBG1_1C00001G1153	5.12e-176	561.0	COG0532@1|root,COG0532@2|Bacteria,2NNRG@2323|unclassified Bacteria	2|Bacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N
SX2_k127_5838209_1	1184267.A11Q_2493	2.233e-09	64.0	2BIKQ@1|root,32CTJ@2|Bacteria,1Q01P@1224|Proteobacteria,42Y1E@68525|delta/epsilon subdivisions	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_5838209_0	935557.ATYB01000014_gene3130	2.355e-112	371.0	COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,2TV6G@28211|Alphaproteobacteria,4BCY5@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Carbamoyltransferase C-terminus	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
SX2_k127_5846920_2	521011.Mpal_1350	2.458e-06	54.0	COG3177@1|root,arCOG03111@2157|Archaea,2Y8I0@28890|Euryarchaeota,2NA98@224756|Methanomicrobia	224756|Methanomicrobia	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic,HTH_DeoR
SX2_k127_5846920_0	1379698.RBG1_1C00001G0201	6.005e-163	519.0	COG0714@1|root,COG0714@2|Bacteria,2NNV8@2323|unclassified Bacteria	2|Bacteria	O	ATPase family associated with various cellular activities (AAA)	moxR	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
SX2_k127_5852252_2	240015.ACP_0181	2.058e-10	73.0	COG4191@1|root,COG4191@2|Bacteria,3Y3X4@57723|Acidobacteria,2JING@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA,HisKA_7TM,PAS,PAS_4
SX2_k127_5852252_0	1379698.RBG1_1C00001G0633	3.511e-29	122.0	COG2172@1|root,COG2172@2|Bacteria,2NQ1S@2323|unclassified Bacteria	2|Bacteria	T	Anti-sigma regulatory factor (Ser Thr protein kinase)	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2,SpoIIE
SX2_k127_5852252_1	1379698.RBG1_1C00001G0632	8.905e-16	78.0	COG1366@1|root,COG1366@2|Bacteria,2NRCS@2323|unclassified Bacteria	2|Bacteria	T	STAS domain	rsbV	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
SX2_k127_5856875_0	1121033.AUCF01000012_gene939	1.428e-25	117.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,2JR8I@204441|Rhodospirillales	204441|Rhodospirillales	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,oligo_HPY
SX2_k127_5856875_1	1120978.KB894080_gene1206	6.556e-12	77.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4HBB9@91061|Bacilli,27HXT@186828|Carnobacteriaceae	91061|Bacilli	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
SX2_k127_5856875_2	1028801.RG1141_CH31750	1.25e-06	60.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TRH6@28211|Alphaproteobacteria,4B8KM@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	MA20_14690	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
SX2_k127_5856875_3	747365.Thena_1423	4.217e-05	53.0	COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,25CDM@186801|Clostridia,42GEZ@68295|Thermoanaerobacterales	186801|Clostridia	E	extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
SX2_k127_5877918_0	1499967.BAYZ01000153_gene1545	1.928e-94	336.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria	2|Bacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_10,TPR_12,TPR_7,TPR_8
SX2_k127_5890829_0	945713.IALB_1778	4.931e-91	304.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria	2|Bacteria	S	IMP dehydrogenase activity	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAPECO1_1312.APECO1_4018,iECABU_c1320.ECABU_c28100,iECP_1309.ECP_2510,iECSF_1327.ECSF_2349,iUTI89_1310.UTI89_C2826,ic_1306.c3027	CBS,IMPDH,NMO
SX2_k127_5890829_1	1379698.RBG1_1C00001G1480	6.962e-52	191.0	COG1579@1|root,COG1579@2|Bacteria,2NPW0@2323|unclassified Bacteria	2|Bacteria	S	C4-type zinc ribbon domain	CP_0228	-	3.5.4.16	ko:K07164,ko:K22391	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	zf-RING_7
SX2_k127_5891977_0	373903.Hore_09660	1.501e-166	543.0	COG2373@1|root,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1,Thiol-ester_cl
SX2_k127_5891977_1	373903.Hore_09670	2.629e-121	403.0	COG4953@1|root,COG4953@2|Bacteria	2|Bacteria	M	penicillin binding	pbpC	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
SX2_k127_5902074_0	1265505.ATUG01000002_gene2648	2.044e-96	325.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WK1B@28221|Deltaproteobacteria,2MHU5@213118|Desulfobacterales	28221|Deltaproteobacteria	S	pfam abc-1	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,APH
SX2_k127_5909832_0	1379698.RBG1_1C00001G0688	8.128e-285	885.0	COG0449@1|root,COG0449@2|Bacteria,2NNWC@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iAF987.Gmet_1487	GATase_6,SIS
SX2_k127_5911250_0	1385510.N781_12240	2.367e-17	85.0	COG1558@1|root,COG1558@2|Bacteria,1V6NB@1239|Firmicutes,4HH4W@91061|Bacilli,2YA9M@289201|Pontibacillus	91061|Bacilli	N	Belongs to the flagella basal body rod proteins family	flgC	GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588	-	ko:K02388	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
SX2_k127_5911250_1	525903.Taci_1338	1.309e-12	72.0	COG1677@1|root,COG1677@2|Bacteria,3TBQA@508458|Synergistetes	508458|Synergistetes	N	Flagellar hook-basal body complex protein FliE	fliE	-	-	ko:K02408	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliE
SX2_k127_5911250_2	351607.Acel_0841	4.367e-12	69.0	COG1766@1|root,COG1766@2|Bacteria,2HG9F@201174|Actinobacteria,4ES5A@85013|Frankiales	201174|Actinobacteria	N	The M ring may be actively involved in energy transduction	fliF	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
SX2_k127_5915801_1	43151.ADAC000756-PA	1.315e-30	136.0	2CMRF@1|root,2QRK8@2759|Eukaryota,38BZ6@33154|Opisthokonta,3BC6D@33208|Metazoa,3CRA6@33213|Bilateria,41W09@6656|Arthropoda,3SING@50557|Insecta,44Y9H@7147|Diptera,45DBE@7148|Nematocera	33208|Metazoa	O	Cartilage oligomeric matrix protein	COMP	GO:0000902,GO:0001501,GO:0001503,GO:0001932,GO:0001934,GO:0001936,GO:0001938,GO:0001968,GO:0002020,GO:0002682,GO:0002684,GO:0002685,GO:0002687,GO:0002688,GO:0002690,GO:0003416,GO:0003417,GO:0003674,GO:0005102,GO:0005178,GO:0005198,GO:0005201,GO:0005488,GO:0005496,GO:0005499,GO:0005509,GO:0005515,GO:0005518,GO:0005539,GO:0005575,GO:0005576,GO:0005604,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005912,GO:0005924,GO:0005927,GO:0006928,GO:0006950,GO:0007155,GO:0007160,GO:0007275,GO:0007399,GO:0007517,GO:0007610,GO:0008150,GO:0008201,GO:0008284,GO:0008289,GO:0009653,GO:0009790,GO:0009887,GO:0009888,GO:0009893,GO:0009987,GO:0010562,GO:0010604,GO:0010941,GO:0012505,GO:0014812,GO:0016043,GO:0016203,GO:0016477,GO:0016525,GO:0016528,GO:0016529,GO:0019220,GO:0019222,GO:0019842,GO:0019899,GO:0021700,GO:0022008,GO:0022603,GO:0022607,GO:0022610,GO:0030030,GO:0030054,GO:0030055,GO:0030154,GO:0030182,GO:0030198,GO:0030334,GO:0030335,GO:0030855,GO:0031012,GO:0031175,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0031589,GO:0031594,GO:0032101,GO:0032103,GO:0032268,GO:0032270,GO:0032501,GO:0032502,GO:0032879,GO:0032989,GO:0032990,GO:0032991,GO:0033554,GO:0033555,GO:0033627,GO:0034103,GO:0034976,GO:0035265,GO:0035989,GO:0036094,GO:0040007,GO:0040011,GO:0040012,GO:0040017,GO:0042127,GO:0042325,GO:0042327,GO:0042981,GO:0043062,GO:0043066,GO:0043067,GO:0043069,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043236,GO:0043237,GO:0043394,GO:0043395,GO:0043931,GO:0043933,GO:0044085,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045202,GO:0045765,GO:0045937,GO:0046872,GO:0048265,GO:0048266,GO:0048468,GO:0048471,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048589,GO:0048646,GO:0048666,GO:0048699,GO:0048705,GO:0048731,GO:0048736,GO:0048799,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0048870,GO:0050678,GO:0050679,GO:0050730,GO:0050731,GO:0050789,GO:0050793,GO:0050794,GO:0050839,GO:0050840,GO:0050896,GO:0050920,GO:0050921,GO:0051093,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051216,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0051270,GO:0051272,GO:0051451,GO:0051674,GO:0051716,GO:0060173,GO:0060231,GO:0060255,GO:0060343,GO:0060346,GO:0060348,GO:0060349,GO:0060350,GO:0060351,GO:0060429,GO:0060538,GO:0060548,GO:0061053,GO:0061061,GO:0061383,GO:0061430,GO:0061448,GO:0062023,GO:0065003,GO:0065007,GO:0070161,GO:0070977,GO:0071603,GO:0071622,GO:0071624,GO:0071695,GO:0071840,GO:0080090,GO:0090022,GO:0090023,GO:0090136,GO:0097159,GO:0097367,GO:0098609,GO:0098868,GO:0120036,GO:0120039,GO:1901342,GO:1901343,GO:1901681,GO:1902622,GO:1902624,GO:2000026,GO:2000145,GO:2000147,GO:2000181	-	ko:K04659	ko04145,ko04151,ko04510,ko04512,ko05144,ko05165,map04145,map04151,map04510,map04512,map05144,map05165	-	-	-	ko00000,ko00001,ko00536,ko04131,ko04147,ko04516	-	-	-	COMP,EGF,EGF_CA,TSP_3,TSP_C
SX2_k127_5915801_2	935866.JAER01000006_gene3252	2.26e-05	53.0	COG1595@1|root,COG1595@2|Bacteria,2GRZW@201174|Actinobacteria,4DSMI@85009|Propionibacteriales	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
SX2_k127_5915801_0	1379698.RBG1_1C00001G1218	2.605e-38	154.0	COG0515@1|root,COG0515@2|Bacteria,2NQWH@2323|unclassified Bacteria	2|Bacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_8
SX2_k127_5922421_0	880073.Calab_2469	9.916e-42	167.0	COG3088@1|root,COG3088@2|Bacteria,2NS4V@2323|unclassified Bacteria	2|Bacteria	O	subunit of a heme lyase	ccmH	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015035,GO:0015036,GO:0016020,GO:0016043,GO:0016491,GO:0016667,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0018193,GO:0018198,GO:0018378,GO:0019538,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098567,GO:1901564	-	ko:K02198,ko:K02200,ko:K04016,ko:K04017,ko:K04018	-	-	R05712	RC00176	ko00000,ko02000	9.B.14.1	-	-	CcmH
SX2_k127_5922421_1	1379698.RBG1_1C00001G1775	3.063e-34	135.0	COG2304@1|root,COG2304@2|Bacteria,2NNYH@2323|unclassified Bacteria	2|Bacteria	NU	von Willebrand factor (vWF) type A domain	batA	-	-	ko:K07114,ko:K12511	-	-	-	-	ko00000,ko02000,ko02044	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA
SX2_k127_5934709_1	880073.Calab_2081	2.076e-09	58.0	COG3291@1|root,COG5276@1|root,COG3291@2|Bacteria,COG5276@2|Bacteria,2NQ2P@2323|unclassified Bacteria	2|Bacteria	P	LVIVD repeat	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	LVIVD
SX2_k127_5934709_0	1379698.RBG1_1C00001G0054	1.52e-207	649.0	COG2502@1|root,COG2502@2|Bacteria,2NNKP@2323|unclassified Bacteria	2|Bacteria	E	Aspartate-ammonia ligase	asnA	GO:0003674,GO:0003824,GO:0004071,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006529,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009987,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.1.1	ko:K01914	ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230	-	R00483	RC00010	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_2719,iECOK1_1307.ECOK1_4193,iECS88_1305.ECS88_4166,iUMN146_1321.UM146_18910,iUTI89_1310.UTI89_C4299	AsnA
SX2_k127_5939690_2	1120968.AUBX01000009_gene655	5.798e-06	51.0	COG1385@1|root,COG1385@2|Bacteria,4NE2S@976|Bacteroidetes,47PRE@768503|Cytophagia	976|Bacteroidetes	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
SX2_k127_5939690_1	1304284.L21TH_1146	4.666e-40	160.0	COG2264@1|root,COG2264@2|Bacteria,1TPKI@1239|Firmicutes,247VY@186801|Clostridia,36FBU@31979|Clostridiaceae	186801|Clostridia	J	Ribosomal protein L11 methyltransferase	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
SX2_k127_5939690_0	1379698.RBG1_1C00001G1488	2.49e-60	213.0	COG0484@1|root,COG0484@2|Bacteria,2NNNG@2323|unclassified Bacteria	2|Bacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0000988,GO:0000989,GO:0003674,GO:0003756,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010556,GO:0015035,GO:0015036,GO:0016020,GO:0016032,GO:0016043,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0016989,GO:0019219,GO:0019222,GO:0022607,GO:0031323,GO:0031326,GO:0032991,GO:0034641,GO:0034645,GO:0042026,GO:0043167,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051704,GO:0055114,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0140096,GO:0140110,GO:1901360,GO:1901576,GO:1903506,GO:2001141	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
SX2_k127_5943247_1	1379698.RBG1_1C00001G0494	9.578e-37	141.0	COG0272@1|root,COG0272@2|Bacteria,2NNSW@2323|unclassified Bacteria	2|Bacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
SX2_k127_5943247_0	247156.NFA_18650	5.983e-105	353.0	COG0469@1|root,COG0469@2|Bacteria,2GJY8@201174|Actinobacteria,4FWQH@85025|Nocardiaceae	201174|Actinobacteria	G	Belongs to the pyruvate kinase family	pyk	GO:0003674,GO:0003824,GO:0004743,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
SX2_k127_5948981_0	1379698.RBG1_1C00001G0933	6.632e-39	162.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K02584,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022,ko03000	-	-	-	FHA,GAF,GAF_2,HTH_8,Sigma54_activat
SX2_k127_5950709_0	1379698.RBG1_1C00001G1773	6.287e-91	309.0	COG0457@1|root,COG0457@2|Bacteria,2NP5J@2323|unclassified Bacteria	2|Bacteria	S	Oxygen tolerance	-	-	-	-	-	-	-	-	-	-	-	-	BatD
SX2_k127_5952629_0	1379698.RBG1_1C00001G0340	1.96e-202	650.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,2NNRF@2323|unclassified Bacteria	2|Bacteria	MU	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641,ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33,2.C.1.2	-	-	Bac_surface_Ag,PD40,POTRA,Peptidase_MA_2
SX2_k127_5953911_0	1125863.JAFN01000001_gene2600	4.631e-103	352.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria	1224|Proteobacteria	C	PFAM FAD linked oxidase domain protein	dld	GO:0003674,GO:0003824,GO:0004457,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008720,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046034,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.1.1.303,1.1.1.4,1.1.2.4,1.1.3.15	ko:K00004,ko:K00102,ko:K00104	ko00620,ko00630,ko00650,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map00650,map01100,map01110,map01120,map01130	-	R00197,R00475,R02855,R02946,R10504	RC00042,RC00044,RC00205,RC00525	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
SX2_k127_5960255_2	562970.Btus_3146	3.64e-11	71.0	COG4625@1|root,COG5492@1|root,COG4625@2|Bacteria,COG5492@2|Bacteria,1V72Z@1239|Firmicutes	1239|Firmicutes	N	PFAM S-layer domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,SLH
SX2_k127_5960255_0	1379698.RBG1_1C00001G1312	1.413e-26	118.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	plnP	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
SX2_k127_5977346_0	1379698.RBG1_1C00001G1671	6.895e-123	407.0	COG1228@1|root,COG1228@2|Bacteria,2NPD9@2323|unclassified Bacteria	2|Bacteria	Q	Amidohydrolase family	-	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
SX2_k127_5978184_1	1379698.RBG1_1C00001G1377	2.177e-12	70.0	COG4409@1|root,COG4409@2|Bacteria,2NRD7@2323|unclassified Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	ASH,BNR_2,Big_3_2,CBM_35,DUF1080,F5_F8_type_C,PKD,RicinB_lectin_2,Trehalase
SX2_k127_5978184_0	1232410.KI421414_gene2877	4.491e-159	530.0	COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,42MMR@68525|delta/epsilon subdivisions,2WJEB@28221|Deltaproteobacteria,43TVP@69541|Desulfuromonadales	28221|Deltaproteobacteria	GM	Polysaccharide biosynthesis protein CapD	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
SX2_k127_6000225_0	1173029.JH980292_gene3090	8.797e-71	271.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G1QI@1117|Cyanobacteria,1H7BP@1150|Oscillatoriales	1117|Cyanobacteria	NU	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_10,TPR_12,TPR_16,TPR_7,TPR_8
SX2_k127_6000225_1	1047013.AQSP01000123_gene1543	6.002e-64	235.0	COG0612@1|root,COG0612@2|Bacteria,2NQ4N@2323|unclassified Bacteria	2|Bacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
SX2_k127_6000225_2	880072.Desac_1033	9.319e-37	155.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,42M74@68525|delta/epsilon subdivisions,2X1XQ@28221|Deltaproteobacteria,2MRAF@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Peptidase M16 domain protein	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
SX2_k127_6000225_3	391603.FBALC1_12572	0.0004093	49.0	COG3209@1|root,COG5295@1|root,COG3209@2|Bacteria,COG5295@2|Bacteria,4PKW4@976|Bacteroidetes,1I1PS@117743|Flavobacteriia	976|Bacteroidetes	MUW	Chaperone of endosialidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S74,YadA_head
SX2_k127_6022520_2	1379698.RBG1_1C00001G1745	8.863e-24	110.0	COG1100@1|root,COG1100@2|Bacteria,2NPDD@2323|unclassified Bacteria	2|Bacteria	K	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein	mglA	GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf,DUF697,MMR_HSR1
SX2_k127_6022520_1	1379698.RBG1_1C00001G1744	6.104e-59	212.0	COG2018@1|root,COG2018@2|Bacteria,2NQXH@2323|unclassified Bacteria	2|Bacteria	S	Roadblock/LC7 domain	mglB	-	-	-	-	-	-	-	-	-	-	-	Robl_LC7
SX2_k127_6022520_0	1379698.RBG1_1C00001G1743	2.006e-226	708.0	COG2804@1|root,COG2804@2|Bacteria,2NNNI@2323|unclassified Bacteria	2|Bacteria	NU	Type II secretion system (T2SS), protein E, N-terminal domain	pilB	-	-	ko:K02454,ko:K02504,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
SX2_k127_6031975_1	717605.Theco_2501	6.401e-71	246.0	COG0124@1|root,COG0124@2|Bacteria,1TP3D@1239|Firmicutes,4HAM2@91061|Bacilli,26RJ5@186822|Paenibacillaceae	91061|Bacilli	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA-synt_His
SX2_k127_6031975_2	1033810.HLPCO_001512	8.983e-44	169.0	COG0311@1|root,COG0311@2|Bacteria,2NPDR@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
SX2_k127_6031975_0	880073.Calab_3060	2.815e-116	381.0	COG0214@1|root,COG0214@2|Bacteria,2NNZ6@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
SX2_k127_6031975_3	298653.Franean1_2157	4.493e-23	102.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
SX2_k127_625212_1	1379698.RBG1_1C00001G1873	1.679e-106	351.0	COG0379@1|root,COG0379@2|Bacteria,2NP47@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
SX2_k127_625212_0	706587.Desti_1495	3.645e-125	416.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
SX2_k127_632728_3	1379698.RBG1_1C00001G1364	1.068e-18	89.0	COG0845@1|root,COG0845@2|Bacteria,2NP97@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	macA	-	-	ko:K02005,ko:K15727	-	-	-	-	ko00000,ko02000	8.A.1.2.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23,OEP
SX2_k127_632728_1	1379698.RBG1_1C00001G1365	4.97e-105	346.0	COG1136@1|root,COG1136@2|Bacteria,2NP53@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX2_k127_632728_2	1379698.RBG1_1C00001G1366	5.05e-101	342.0	COG0577@1|root,COG0577@2|Bacteria,2NQMU@2323|unclassified Bacteria	2|Bacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX2_k127_632728_0	1379698.RBG1_1C00001G1367	9.152e-120	397.0	COG0577@1|root,COG0577@2|Bacteria,2NNN0@2323|unclassified Bacteria	2|Bacteria	V	COGs COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX2_k127_644316_0	316067.Geob_3002	2.967e-93	326.0	COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,42M62@68525|delta/epsilon subdivisions,2WJ83@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Polysaccharide export protein	-	-	-	-	-	-	-	-	-	-	-	-	Poly_export,SLBB
SX2_k127_663434_2	986075.CathTA2_1273	2.154e-10	69.0	COG0500@1|root,COG2226@2|Bacteria,1V45D@1239|Firmicutes,4HGZ2@91061|Bacilli	91061|Bacilli	Q	SAM-dependent methyltransferase	ubiE7	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
SX2_k127_663434_0	1121430.JMLG01000005_gene770	3.711e-180	588.0	COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,260F2@186807|Peptococcaceae	186801|Clostridia	L	PFAM UvrD REP helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
SX2_k127_663434_1	1379698.RBG1_1C00001G1101	1.626e-21	99.0	COG1404@1|root,COG2911@1|root,COG1404@2|Bacteria,COG2911@2|Bacteria,2NP8X@2323|unclassified Bacteria	2|Bacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Cohesin,FlgD_ig,Inhibitor_I9,Peptidase_S74,Peptidase_S8
SX2_k127_673235_6	1089553.Tph_c04170	4.162e-36	141.0	COG1142@1|root,COG1142@2|Bacteria,1UHYS@1239|Firmicutes,24JZC@186801|Clostridia,42H3B@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_11,Fer4_3,Fer4_4,Fer4_6,Fer4_9
SX2_k127_673235_5	118005.AWNK01000001_gene2101	2.938e-52	195.0	2CAZH@1|root,2Z7RU@2|Bacteria	2|Bacteria	-	-	sdhC	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
SX2_k127_673235_0	324602.Caur_1881	0.0	1029.0	COG1053@1|root,COG1053@2|Bacteria,2G5YB@200795|Chloroflexi,374WX@32061|Chloroflexia	32061|Chloroflexia	C	TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
SX2_k127_673235_3	653733.Selin_2130	8.715e-114	371.0	COG0479@1|root,COG0479@2|Bacteria	2|Bacteria	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	frdB	-	1.3.5.1,1.3.5.4	ko:K00240,ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2395	Fer2_3,Fer4_7,Fer4_8
SX2_k127_673235_4	1158612.I580_02243	1.656e-58	211.0	COG0500@1|root,COG2226@2|Bacteria,1UX0M@1239|Firmicutes,4IDQK@91061|Bacilli,4B4ZV@81852|Enterococcaceae	91061|Bacilli	Q	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
SX2_k127_673235_2	1121104.AQXH01000001_gene1976	1.204e-138	452.0	COG0534@1|root,COG0534@2|Bacteria,4NG7Q@976|Bacteroidetes,1IWU0@117747|Sphingobacteriia	976|Bacteroidetes	V	MatE	dinF	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
SX2_k127_673235_1	1340493.JNIF01000003_gene3441	1.978e-161	529.0	COG0526@1|root,COG3391@1|root,COG0526@2|Bacteria,COG3391@2|Bacteria,3Y3U8@57723|Acidobacteria	57723|Acidobacteria	CO	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DsbD
SX2_k127_67654_0	1379698.RBG1_1C00001G0988	2.068e-107	368.0	COG1413@1|root,COG1413@2|Bacteria,2NQWQ@2323|unclassified Bacteria	2|Bacteria	C	lyase activity	-	-	3.4.24.3	ko:K01387,ko:K03301	-	-	-	-	ko00000,ko01000,ko01002,ko02042	2.A.12	-	-	DUF1822,DUF4132,HEAT_2,HEAT_PBS,Peptidase_M9,Peptidase_M9_N,Sulfatase
SX2_k127_67654_1	1379698.RBG1_1C00001G1205	4.746e-11	66.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SX2_k127_677080_1	1379698.RBG1_1C00001G0222	2.8e-117	394.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2NNR2@2323|unclassified Bacteria	2|Bacteria	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
SX2_k127_677080_0	1379698.RBG1_1C00001G0646	2.891e-259	809.0	COG0466@1|root,COG0466@2|Bacteria,2NNNN@2323|unclassified Bacteria	2|Bacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
SX2_k127_681159_0	1279009.ADICEAN_01551	5.613e-57	201.0	COG0377@1|root,COG0377@2|Bacteria,4NFKT@976|Bacteroidetes,47JYD@768503|Cytophagia	976|Bacteroidetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
SX2_k127_681159_2	517417.Cpar_1308	2.022e-37	145.0	COG0838@1|root,COG0838@2|Bacteria,1FDY8@1090|Chlorobi	1090|Chlorobi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
SX2_k127_681159_1	1379698.RBG1_1C00001G0432	5.334e-54	205.0	2BV2G@1|root,32QFC@2|Bacteria,2NR6X@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_681159_3	1209989.TepiRe1_1192	3.267e-33	130.0	COG0481@1|root,COG0481@2|Bacteria,1TP0G@1239|Firmicutes,247V8@186801|Clostridia,42F8U@68295|Thermoanaerobacterales	186801|Clostridia	J	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
SX2_k127_685869_2	1191523.MROS_1921	2.427e-113	373.0	COG0126@1|root,COG0126@2|Bacteria	2|Bacteria	F	phosphoglycerate kinase activity	pgk	GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
SX2_k127_685869_1	290318.Cvib_1310	2.58e-128	419.0	COG0057@1|root,COG0057@2|Bacteria,1FDJ0@1090|Chlorobi	1090|Chlorobi	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	-	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
SX2_k127_685869_0	1379698.RBG1_1C00001G1008	6.303e-145	467.0	COG0205@1|root,COG0205@2|Bacteria,2NNY2@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11,2.7.1.90	ko:K00850,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
SX2_k127_708243_1	234267.Acid_3454	7.112e-18	94.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,3Y7SH@57723|Acidobacteria	57723|Acidobacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
SX2_k127_708243_0	1089545.KB913037_gene661	8.388e-24	107.0	COG1595@1|root,COG1595@2|Bacteria,2GJUI@201174|Actinobacteria,4E333@85010|Pseudonocardiales	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4
SX2_k127_713785_3	1379698.RBG1_1C00001G0488	7.202e-28	122.0	COG4447@1|root,COG4447@2|Bacteria,2NRAH@2323|unclassified Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Cu_amine_oxidN1,F5_F8_type_C
SX2_k127_713785_2	1144275.COCOR_06251	2.409e-39	159.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,42NIH@68525|delta/epsilon subdivisions,2WQJT@28221|Deltaproteobacteria,2YV3J@29|Myxococcales	28221|Deltaproteobacteria	FP	Ppx GppA	gppA-1	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
SX2_k127_713785_0	589865.DaAHT2_1287	5.677e-93	315.0	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,42M3T@68525|delta/epsilon subdivisions,2WIV8@28221|Deltaproteobacteria,2MIMG@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Electron transfer flavoprotein, alpha subunit	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha,Fer4
SX2_k127_713785_1	1379698.RBG1_1C00001G0484	2.707e-85	295.0	COG1641@1|root,COG1641@2|Bacteria,2NNX0@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function DUF111	larC	-	4.99.1.12	ko:K06898,ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
SX2_k127_721491_0	1379698.RBG1_1C00001G0866	3.419e-64	237.0	COG1674@1|root,COG1674@2|Bacteria,2NNVB@2323|unclassified Bacteria	2|Bacteria	D	Ftsk_gamma	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
SX2_k127_755567_0	1379698.RBG1_1C00001G1511	1.596e-110	374.0	COG0312@1|root,COG0312@2|Bacteria,2NPIS@2323|unclassified Bacteria	2|Bacteria	S	Putative modulator of DNA gyrase	tldD2	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
SX2_k127_762446_2	234267.Acid_3938	1.316e-52	191.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
SX2_k127_762446_0	1185876.BN8_06112	1.135e-112	372.0	COG1446@1|root,COG1446@2|Bacteria,4NF1U@976|Bacteroidetes,47K5N@768503|Cytophagia	976|Bacteroidetes	E	PFAM peptidase T2 asparaginase 2	-	-	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2
SX2_k127_762446_1	459349.CLOAM0299	2.832e-90	306.0	COG1167@1|root,COG1167@2|Bacteria,2NQG7@2323|unclassified Bacteria	2|Bacteria	EK	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
SX2_k127_768057_1	1379698.RBG1_1C00001G0396	2.056e-35	145.0	COG0707@1|root,COG0707@2|Bacteria,2NP4Z@2323|unclassified Bacteria	2|Bacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0050511,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.4.1.227,6.3.2.8	ko:K01924,ko:K02563	ko00471,ko00550,ko01100,ko01502,ko04112,map00471,map00550,map01100,map01502,map04112	-	R03193,R05032,R05662	RC00005,RC00049,RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	GT28	iLJ478.TM0232,iSFV_1184.SFV_0083,iSF_1195.SF0087,iSFxv_1172.SFxv_0091,iS_1188.S0089	Glyco_tran_28_C,Glyco_transf_28
SX2_k127_768057_0	1379698.RBG1_1C00001G0395	4.681e-83	289.0	COG0772@1|root,COG0772@2|Bacteria,2NP3P@2323|unclassified Bacteria	2|Bacteria	D	Belongs to the SEDS family	ftsW	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008360,GO:0009987,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032153,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505	2.4.1.227	ko:K02563,ko:K03588	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011,ko02000,ko03036	2.A.103.1	GT28	-	FTSW_RODA_SPOVE
SX2_k127_768057_2	587753.EY04_25665	4.069e-14	74.0	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008764,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iAPECO1_1312.APECO1_1898,iECNA114_1301.ECNA114_0081,iECOK1_1307.ECOK1_0089,iECP_1309.ECP_0090,iECS88_1305.ECS88_0091,iECSF_1327.ECSF_0098,iLF82_1304.LF82_1418,iNRG857_1313.NRG857_00450,iUMN146_1321.UM146_23225,iUTI89_1310.UTI89_C0097	Mur_ligase_C,Mur_ligase_M
SX2_k127_769267_0	395495.Lcho_4288	4.036e-187	595.0	COG1061@1|root,COG3886@1|root,COG1061@2|Bacteria,COG3886@2|Bacteria,1MV9F@1224|Proteobacteria,2VHAI@28216|Betaproteobacteria,1KN6M@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	helicase superfamily c-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3427,Helicase_C,Methyltransf_25,Mrr_cat,PLDc_2,ResIII
SX2_k127_7776_0	755732.Fluta_0362	2.789e-165	529.0	COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,1HX2H@117743|Flavobacteriia,2PAGA@246874|Cryomorphaceae	976|Bacteroidetes	V	TIGRFAM The (Largely Gram-negative Bacterial) Hydrophobe Amphiphile Efflux-1 (HAE1) Family	bepE_4	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
SX2_k127_7776_1	697281.Mahau_0741	6.985e-100	338.0	COG1164@1|root,COG1164@2|Bacteria,1TP4P@1239|Firmicutes,248TP@186801|Clostridia,42EXS@68295|Thermoanaerobacterales	186801|Clostridia	E	M3B, thimet oligopeptidase F	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
SX2_k127_778202_0	1191523.MROS_2800	2.135e-228	712.0	COG0334@1|root,COG0334@2|Bacteria	2|Bacteria	E	glutamate dehydrogenase [NAD(P)+] activity	gluD	GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0004354,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.2,1.4.1.3,1.4.1.4	ko:K00260,ko:K00261,ko:K00262	ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iJN678.gdhA	ELFV_dehydrog,ELFV_dehydrog_N
SX2_k127_778202_1	1047013.AQSP01000056_gene1916	1.998e-79	271.0	COG1136@1|root,COG1136@2|Bacteria,2NP53@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX2_k127_778202_2	518766.Rmar_1442	1.758e-14	76.0	COG0577@1|root,COG0577@2|Bacteria,4NECN@976|Bacteroidetes,1FIY8@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX2_k127_779771_0	861299.J421_3828	1.29e-115	388.0	COG0466@1|root,COG0466@2|Bacteria,1ZTCP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
SX2_k127_805780_0	1157490.EL26_03815	5.188e-109	364.0	COG0018@1|root,COG0018@2|Bacteria,1TPEZ@1239|Firmicutes,4HAR3@91061|Bacilli,2798F@186823|Alicyclobacillaceae	91061|Bacilli	J	Arginyl tRNA synthetase N terminal dom	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
SX2_k127_805780_1	351160.RCIX86	1.838e-56	213.0	COG0477@1|root,arCOG00132@2157|Archaea,2XYHV@28890|Euryarchaeota,2NAK2@224756|Methanomicrobia	224756|Methanomicrobia	G	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX2_k127_805780_2	1340493.JNIF01000003_gene4248	2.036e-26	113.0	COG0253@1|root,COG0253@2|Bacteria,3Y4EC@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
SX2_k127_854730_2	1191523.MROS_1308	2.557e-07	61.0	2C4MF@1|root,300D5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_854730_0	1379698.RBG1_1C00001G1427	3.093e-73	250.0	COG0231@1|root,COG0231@2|Bacteria,2NPID@2323|unclassified Bacteria	2|Bacteria	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006448,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072344,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112,GO:2000113,GO:2001124,GO:2001125	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
SX2_k127_854730_1	330214.NIDE0992	2.581e-39	151.0	COG1039@1|root,COG1039@2|Bacteria	2|Bacteria	L	RNA-DNA hybrid ribonuclease activity	rnhC	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03471	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DUF3378,RNase_HII
SX2_k127_864547_0	1379698.RBG1_1C00001G0312	7.837e-178	561.0	COG1158@1|root,COG1158@2|Bacteria,2NNXC@2323|unclassified Bacteria	2|Bacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576	-	ko:K02887,ko:K03628	ko03010,ko03018,map03010,map03018	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
SX2_k127_864547_2	945713.IALB_2385	4.073e-40	151.0	COG0799@1|root,COG0799@2|Bacteria	2|Bacteria	S	negative regulation of ribosome biogenesis	rsfS	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113	2.7.7.18	ko:K00969,ko:K09710	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	RsfS
SX2_k127_864547_3	1191523.MROS_2301	5.464e-06	55.0	COG1316@1|root,COG1316@2|Bacteria	2|Bacteria	K	TRANSCRIPTIONal	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
SX2_k127_864547_1	1196322.A370_02388	5.278e-45	169.0	COG1207@1|root,COG1207@2|Bacteria,1TP88@1239|Firmicutes,248Z3@186801|Clostridia,36EN8@31979|Clostridiaceae	186801|Clostridia	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase
SX2_k127_873745_3	1379698.RBG1_1C00001G1748	4.309e-38	154.0	COG0457@1|root,COG0457@2|Bacteria,2NS1B@2323|unclassified Bacteria	2|Bacteria	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
SX2_k127_873745_0	1379698.RBG1_1C00001G1750	4.752e-99	336.0	COG0457@1|root,COG0457@2|Bacteria,2NRMR@2323|unclassified Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388
SX2_k127_873745_1	1379698.RBG1_1C00001G1751	1.555e-86	313.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,2NP4I@2323|unclassified Bacteria	2|Bacteria	U	Metallo-beta-lactamase superfamily	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
SX2_k127_873745_2	1379698.RBG1_1C00001G1752	3.41e-46	176.0	COG0728@1|root,COG0728@2|Bacteria,2NNX8@2323|unclassified Bacteria	2|Bacteria	U	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
SX2_k127_874813_1	1121428.DESHY_50085___1	4.019e-35	144.0	COG0697@1|root,COG0697@2|Bacteria,1TPUW@1239|Firmicutes,247X1@186801|Clostridia,261JW@186807|Peptococcaceae	186801|Clostridia	EG	PFAM EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SX2_k127_874813_0	573061.Clocel_3666	3.169e-68	241.0	COG0535@1|root,COG0535@2|Bacteria,1TR85@1239|Firmicutes,249NQ@186801|Clostridia,36DDQ@31979|Clostridiaceae	186801|Clostridia	C	PFAM Radical SAM domain protein	-	-	-	ko:K22226	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
SX2_k127_904996_0	379066.GAU_0649	1.406e-105	355.0	COG2204@1|root,COG2204@2|Bacteria,1ZSW0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
SX2_k127_904996_1	290397.Adeh_3342	6.887e-43	174.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria,2YUYF@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	ntrY	-	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
SX2_k127_907332_0	1121104.AQXH01000001_gene2024	1.681e-52	194.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,4NI98@976|Bacteroidetes,1IR5G@117747|Sphingobacteriia	976|Bacteroidetes	KT	Serine phosphatase RsbU regulator of sigma subunit	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	SpoIIE
SX2_k127_907332_1	1379698.RBG1_1C00001G0634	2.771e-47	175.0	COG1051@1|root,COG1051@2|Bacteria,2NPZ5@2323|unclassified Bacteria	2|Bacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Nudix_N_2
SX2_k127_907332_2	1042209.HK44_004165	4.914e-07	61.0	COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,1RNPP@1236|Gammaproteobacteria,1YS50@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	T	Histidine kinase	narX	GO:0000155,GO:0000160,GO:0001101,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010167,GO:0016020,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0033554,GO:0035556,GO:0036211,GO:0042221,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071229,GO:0071241,GO:0071249,GO:0071250,GO:0071704,GO:0071944,GO:0080033,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170	2.7.13.3	ko:K07673,ko:K07674	ko02020,map02020	M00471,M00472	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA_3,PilJ
SX2_k127_915971_1	945713.IALB_2870	1.074e-35	154.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	BatA
SX2_k127_915971_0	926561.KB900620_gene2928	7.031e-66	235.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247U6@186801|Clostridia,3WA67@53433|Halanaerobiales	186801|Clostridia	S	PFAM ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
SX2_k127_928225_1	373903.Hore_15740	1.288e-49	182.0	COG2316@1|root,COG2316@2|Bacteria,1TSF7@1239|Firmicutes,24A1B@186801|Clostridia,3WANC@53433|Halanaerobiales	186801|Clostridia	S	PFAM metal-dependent phosphohydrolase HD sub domain	-	-	-	ko:K06951	-	-	-	-	ko00000	-	-	-	HD
SX2_k127_928225_0	1379698.RBG1_1C00001G1242	9.006e-113	378.0	COG2270@1|root,COG2270@2|Bacteria,2NP3G@2323|unclassified Bacteria	2|Bacteria	S	Vacuole effluxer Atg22 like	yxiO	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22,MFS_1
SX2_k127_951520_0	1379698.RBG1_1C00001G1432	2.389e-87	300.0	COG1196@1|root,COG1196@2|Bacteria,2NNYZ@2323|unclassified Bacteria	2|Bacteria	D	Required for chromosome condensation and partitioning	smc	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03529,ko:K19171	-	-	-	-	ko00000,ko02048,ko03036	-	-	-	SMC_N,SMC_hinge
SX2_k127_951520_1	572479.Hprae_0996	5.207e-08	64.0	COG1426@1|root,COG1426@2|Bacteria,1V1N7@1239|Firmicutes,24M2Q@186801|Clostridia,3WC3F@53433|Halanaerobiales	186801|Clostridia	S	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4115,HTH_25
SX2_k127_96307_1	1379698.RBG1_1C00001G1125	1.13e-33	132.0	COG1692@1|root,COG1692@2|Bacteria,2NNW9@2323|unclassified Bacteria	2|Bacteria	S	YmdB-like protein	ymdB	GO:0003674,GO:0003824,GO:0004112,GO:0004113,GO:0008081,GO:0016787,GO:0016788,GO:0042578	-	ko:K02029,ko:K02030,ko:K09769	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	YmdB
SX2_k127_96307_0	1379698.RBG1_1C00001G1123	9.83e-213	672.0	COG1418@1|root,COG1418@2|Bacteria,2NNU5@2323|unclassified Bacteria	2|Bacteria	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
SX2_k127_96307_2	1379698.RBG1_1C00001G1122	3.445e-21	96.0	COG3027@1|root,COG3027@2|Bacteria,2NQ5R@2323|unclassified Bacteria	2|Bacteria	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	zapA	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
SX2_k127_96307_3	279714.FuraDRAFT_3113	5.229e-20	92.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,2VHR1@28216|Betaproteobacteria,2KPX3@206351|Neisseriales	206351|Neisseriales	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
SX2_k127_982528_0	269797.Mbar_A0123	1.401e-37	153.0	COG3315@1|root,arCOG03588@2157|Archaea,2XZ8B@28890|Euryarchaeota,2NAQZ@224756|Methanomicrobia	224756|Methanomicrobia	Q	Leucine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	LCM
SX2_k127_982528_3	1123237.Salmuc_03053	4.097e-06	57.0	COG1183@1|root,COG1183@2|Bacteria,1NGCJ@1224|Proteobacteria,2TS1K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP	pcs	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050520,GO:0071704,GO:0090407,GO:1901576	2.7.8.24	ko:K01004	ko00564,ko01110,map00564,map01110	-	R05794	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
SX2_k127_982528_1	1321784.HMPREF1987_00628	8.163e-28	122.0	COG4589@1|root,COG4589@2|Bacteria,1TT0Q@1239|Firmicutes,25HJP@186801|Clostridia,25QVC@186804|Peptostreptococcaceae	186801|Clostridia	S	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
SX2_k127_982528_2	1268072.PSAB_02050	2.196e-16	87.0	COG1597@1|root,COG1597@2|Bacteria,1TQJH@1239|Firmicutes,4HJ8D@91061|Bacilli,26R8C@186822|Paenibacillaceae	91061|Bacilli	I	Lipid kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
SX2_k127_996752_1	1047013.AQSP01000120_gene951	1.857e-31	137.0	COG4104@1|root,COG4104@2|Bacteria	2|Bacteria	T	PAAR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	PAAR_motif
SX2_k127_996752_0	880073.Calab_1785	2.421e-278	873.0	COG0709@1|root,COG1104@1|root,COG0709@2|Bacteria,COG1104@2|Bacteria,2NNVR@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	selD	-	2.7.9.3,2.8.1.7	ko:K01008,ko:K04487	ko00450,ko00730,ko01100,ko04122,map00450,map00730,map01100,map04122	-	R03595,R07460,R11528,R11529	RC00002,RC01789,RC02313,RC02878	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	AIRS,AIRS_C,Aminotran_5
## 1444 queries scanned
## Total time (seconds): 293.2582473754883
## Rate: 4.92 q/s