## Fri Oct 18 17:40:23 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/Potential_rubisco_autotrophic/SX3_bin.33.fa -m mmseqs --itype genome -o SX3_bin.33 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/all_bins_1385/SX3_bin.33 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
SX3_k127_1009063_2	889378.Spiaf_1822	8.817e-47	173.0	COG0705@1|root,COG0705@2|Bacteria,2J7J3@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Rhomboid family	-	-	-	ko:K02441	-	-	-	-	ko00000	-	-	-	Rhomboid
SX3_k127_1009063_0	530564.Psta_1627	3.292e-172	565.0	COG5316@1|root,COG5316@2|Bacteria,2IY3B@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
SX3_k127_1009063_3	1195236.CTER_0563	6.741e-37	150.0	COG0145@1|root,COG0145@2|Bacteria,1V3GN@1239|Firmicutes,25DNJ@186801|Clostridia,3WPEF@541000|Ruminococcaceae	186801|Clostridia	EQ	Protein of unknown function (DUF1638)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1638
SX3_k127_1009063_1	545695.TREAZ_2079	1.969e-110	366.0	COG0714@1|root,COG0714@2|Bacteria,2J5SG@203691|Spirochaetes	203691|Spirochaetes	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
SX3_k127_1009063_5	545694.TREPR_0179	2.218e-23	117.0	29XQJ@1|root,30JG9@2|Bacteria,2J89K@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
SX3_k127_1009063_4	545694.TREPR_0180	2.255e-26	121.0	COG1305@1|root,COG1305@2|Bacteria,2J681@203691|Spirochaetes	203691|Spirochaetes	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_7,TPR_8,Transglut_core
SX3_k127_1016881_18	1206726.BAFV01000124_gene6425	2.753e-05	52.0	2DS51@1|root,33EJB@2|Bacteria,2IM77@201174|Actinobacteria,4G7TM@85025|Nocardiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1761)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1761
SX3_k127_1016881_6	1122918.KB907256_gene2237	1.516e-43	164.0	COG3832@1|root,COG3832@2|Bacteria,1V799@1239|Firmicutes,4HHAD@91061|Bacilli,26WTI@186822|Paenibacillaceae	91061|Bacilli	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
SX3_k127_1016881_11	118173.KB235914_gene2726	4.88e-25	106.0	COG1396@1|root,COG1396@2|Bacteria,1G7Q5@1117|Cyanobacteria,1HCFQ@1150|Oscillatoriales	1117|Cyanobacteria	K	PFAM Helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
SX3_k127_1016881_10	118173.KB235914_gene2725	6.876e-26	108.0	COG4679@1|root,COG4679@2|Bacteria,1G6N5@1117|Cyanobacteria,1HC3R@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
SX3_k127_1016881_8	693661.Arcve_0646	2.078e-34	137.0	arCOG06733@1|root,arCOG06733@2157|Archaea,2Y62E@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1016881_9	304371.MCP_0425	2.189e-33	140.0	COG0716@1|root,arCOG00519@2157|Archaea,2XXTN@28890|Euryarchaeota,2NB5F@224756|Methanomicrobia	224756|Methanomicrobia	C	Flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_3
SX3_k127_1016881_4	1365176.N186_07720	1.565e-75	272.0	arCOG00137@1|root,arCOG00137@2157|Archaea	2157|Archaea	S	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX3_k127_1016881_0	1501230.ET33_02970	3.99e-296	938.0	COG2909@1|root,COG2909@2|Bacteria,1UIMV@1239|Firmicutes,4HD7H@91061|Bacilli,26QDM@186822|Paenibacillaceae	91061|Bacilli	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	GerE
SX3_k127_1016881_5	42256.RradSPS_0358	4.903e-65	246.0	COG2909@1|root,COG2909@2|Bacteria,2HENR@201174|Actinobacteria,4CPC9@84995|Rubrobacteria	84995|Rubrobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,AAA_22,GerE
SX3_k127_1016881_17	1307761.L21SP2_0369	2.207e-05	51.0	COG0399@1|root,COG0399@2|Bacteria,2JA54@203691|Spirochaetes	203691|Spirochaetes	M	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
SX3_k127_1016881_7	1263831.F543_22830	1.906e-37	152.0	COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria	1224|Proteobacteria	M	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
SX3_k127_1016881_1	1485544.JQKP01000003_gene91	9.139e-93	312.0	COG3865@1|root,COG3865@2|Bacteria,1N7IY@1224|Proteobacteria,2VSAQ@28216|Betaproteobacteria,44W4Q@713636|Nitrosomonadales	28216|Betaproteobacteria	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
SX3_k127_1016881_3	1331060.RLDS_11690	1.896e-88	301.0	COG2253@1|root,COG2253@2|Bacteria,1NJT9@1224|Proteobacteria,2U243@28211|Alphaproteobacteria,2K44K@204457|Sphingomonadales	204457|Sphingomonadales	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
SX3_k127_1016881_2	671143.DAMO_2888	1.644e-90	305.0	COG5340@1|root,COG5340@2|Bacteria,2NRBK@2323|unclassified Bacteria	2|Bacteria	K	Transcriptional regulator, AbiEi antitoxin	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_4
SX3_k127_1016881_15	1312954.KI914850_gene1951	1.32e-06	56.0	COG3865@1|root,COG3865@2|Bacteria,2IIAX@201174|Actinobacteria,1WA5P@1268|Micrococcaceae	201174|Actinobacteria	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
SX3_k127_1016881_16	102232.GLO73106DRAFT_00018720	5.548e-06	51.0	COG1598@1|root,COG1598@2|Bacteria,1GAU7@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1016881_13	449447.MAE_09140	5.245e-13	71.0	COG1724@1|root,COG1724@2|Bacteria,1G8K9@1117|Cyanobacteria	1117|Cyanobacteria	N	PFAM YcfA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
SX3_k127_1024311_17	1123277.KB893174_gene6062	1.366e-11	77.0	COG1520@1|root,COG1520@2|Bacteria,4NK4X@976|Bacteroidetes,47KWI@768503|Cytophagia	976|Bacteroidetes	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1024311_11	665571.STHERM_c21800	2.591e-33	141.0	COG0791@1|root,COG0791@2|Bacteria,2JB19@203691|Spirochaetes	203691|Spirochaetes	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	CHAP,NLPC_P60
SX3_k127_1024311_10	889378.Spiaf_2608	1.191e-46	190.0	COG0666@1|root,COG0666@2|Bacteria,2J5FX@203691|Spirochaetes	203691|Spirochaetes	S	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_4,Ank_5
SX3_k127_1024311_14	1283287.KB822576_gene4079	8.395e-20	95.0	COG1848@1|root,COG1848@2|Bacteria,2H7T3@201174|Actinobacteria,4DW1B@85009|Propionibacteriales	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
SX3_k127_1024311_19	1370125.AUWT01000018_gene4070	1.333e-08	61.0	COG5418@1|root,COG5418@2|Bacteria,2H2GT@201174|Actinobacteria,23CAT@1762|Mycobacteriaceae	201174|Actinobacteria	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1024311_20	1280673.AUJJ01000025_gene1247	2e-08	62.0	COG0167@1|root,COG0493@1|root,COG1146@1|root,COG0167@2|Bacteria,COG0493@2|Bacteria,COG1146@2|Bacteria,1TRPI@1239|Firmicutes,24A0Z@186801|Clostridia,4BWSJ@830|Butyrivibrio	186801|Clostridia	CEF	4Fe-4S dicluster domain	preA	-	1.3.1.1	ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046	R00977,R01414,R11026	RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh,Fer4_20,Fer4_21,Fer4_6
SX3_k127_1024311_12	694427.Palpr_0202	2.126e-27	120.0	COG1592@1|root,COG1592@2|Bacteria	2|Bacteria	C	Rubrerythrin	-	-	1.15.1.2	ko:K05919,ko:K07798	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko02000	2.A.6.1.4,8.A.1	-	-	Desulfoferrod_N,HlyD_D23,Rubrerythrin
SX3_k127_1024311_15	1042326.AZNV01000029_gene3560	1.854e-19	104.0	2CH5W@1|root,3020J@2|Bacteria,1Q73P@1224|Proteobacteria,2VD7X@28211|Alphaproteobacteria,4BIB8@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1024311_9	311424.DhcVS_1501	2.348e-54	211.0	COG1131@1|root,COG1131@2|Bacteria,2G5PC@200795|Chloroflexi,34CZ8@301297|Dehalococcoidia	301297|Dehalococcoidia	V	Domain of unknown function (DUF4162)	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SX3_k127_1024311_6	1499967.BAYZ01000123_gene2495	1.035e-107	364.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
SX3_k127_1024311_1	1499967.BAYZ01000032_gene1136	5.875e-204	645.0	COG2407@1|root,COG2407@2|Bacteria,2NR9P@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the conversion of L-arabinose to L-ribulose	-	-	5.3.1.4	ko:K01804	ko00040,ko01100,map00040,map01100	-	R01761	RC00516	ko00000,ko00001,ko01000	-	-	-	Arabinose_Isome,Fucose_iso_C
SX3_k127_1024311_16	1237149.C900_00772	4.33e-13	75.0	29E7I@1|root,3015I@2|Bacteria,4NNFG@976|Bacteroidetes,47T83@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF1761)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1761
SX3_k127_1024311_13	643648.Slip_1601	6.598e-24	106.0	COG1569@1|root,COG1569@2|Bacteria,1VNTR@1239|Firmicutes,259BY@186801|Clostridia,42KTX@68298|Syntrophomonadaceae	186801|Clostridia	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
SX3_k127_1024311_18	573413.Spirs_0696	4.66e-09	61.0	COG4118@1|root,COG4118@2|Bacteria,2J9CA@203691|Spirochaetes	203691|Spirochaetes	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
SX3_k127_1024311_2	1499967.BAYZ01000074_gene2170	2.343e-203	648.0	COG0469@1|root,COG0469@2|Bacteria,2NNKX@2323|unclassified Bacteria	2|Bacteria	G	Belongs to the pyruvate kinase family	pyk	GO:0003674,GO:0003824,GO:0004743,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.1.40,2.7.7.4	ko:K00873,ko:K00958	ko00010,ko00230,ko00261,ko00450,ko00620,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00261,map00450,map00620,map00920,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050,M00176,M00596	R00200,R00430,R00529,R01138,R01858,R02320,R04929	RC00002,RC00015,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
SX3_k127_1024311_5	555779.Dthio_PD3715	1.312e-153	495.0	COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,42MFI@68525|delta/epsilon subdivisions,2WKXD@28221|Deltaproteobacteria,2MAH6@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
SX3_k127_1024311_3	1121405.dsmv_1129	1.222e-184	616.0	COG3852@1|root,COG4191@1|root,COG3852@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2X734@28221|Deltaproteobacteria,2MIC0@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
SX3_k127_1024311_8	62928.azo2362	3.196e-69	267.0	COG0642@1|root,COG0784@1|root,COG3829@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,COG5002@2|Bacteria,1MUY7@1224|Proteobacteria,2VIXT@28216|Betaproteobacteria,2KUH6@206389|Rhodocyclales	206389|Rhodocyclales	T	Histidine kinase	-	-	2.7.13.3	ko:K20975	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Response_reg
SX3_k127_1024311_4	573413.Spirs_4003	6.79e-171	574.0	COG0188@1|root,COG0188@2|Bacteria,2J5Y9@203691|Spirochaetes	203691|Spirochaetes	L	Belongs to the type II topoisomerase GyrA ParC subunit family	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_topoisoIV
SX3_k127_1024311_0	243275.TDE_2245	2.807e-246	775.0	COG0187@1|root,COG0187@2|Bacteria,2J6PT@203691|Spirochaetes	203691|Spirochaetes	L	DNA topoisomerase	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
SX3_k127_1024311_7	545695.TREAZ_2760	1.214e-69	241.0	28MXM@1|root,2Z8AT@2|Bacteria,2JBFX@203691|Spirochaetes	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1071809_3	744872.Spica_2566	2.916e-129	429.0	COG1066@1|root,COG1066@2|Bacteria,2J5WN@203691|Spirochaetes	203691|Spirochaetes	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	ATPase,ChlI,Lon_C
SX3_k127_1071809_5	1480694.DC28_09140	1.209e-44	185.0	COG1538@1|root,COG1538@2|Bacteria,2J914@203691|Spirochaetes	203691|Spirochaetes	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
SX3_k127_1071809_0	1480694.DC28_09150	3.506e-305	968.0	COG0841@1|root,COG0841@2|Bacteria,2J5HW@203691|Spirochaetes	203691|Spirochaetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
SX3_k127_1071809_4	889378.Spiaf_0096	4.609e-83	292.0	COG0845@1|root,COG0845@2|Bacteria,2J88F@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
SX3_k127_1071809_6	1307761.L21SP2_0030	1.631e-28	122.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	yhgD	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141	-	ko:K03577,ko:K09017	-	M00647	-	-	ko00000,ko00002,ko03000	-	-	-	TetR_N
SX3_k127_1071809_1	1123274.KB899407_gene239	1.667e-212	673.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2J65C@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
SX3_k127_1071809_7	573413.Spirs_0264	1.783e-16	93.0	COG4221@1|root,COG4221@2|Bacteria,2J85X@203691|Spirochaetes	203691|Spirochaetes	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SX3_k127_1071809_2	1521187.JPIM01000063_gene2480	2.121e-168	553.0	COG2518@1|root,COG2518@2|Bacteria	2|Bacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm2	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
SX3_k127_1072432_7	744872.Spica_2610	4.355e-30	124.0	COG0724@1|root,COG0724@2|Bacteria,2J8UF@203691|Spirochaetes	203691|Spirochaetes	S	PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
SX3_k127_1072432_5	1121918.ARWE01000001_gene2008	2.87e-47	177.0	COG2606@1|root,COG2606@2|Bacteria,1RGX5@1224|Proteobacteria,42RNH@68525|delta/epsilon subdivisions,2X5NY@28221|Deltaproteobacteria,43UM6@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Aminoacyl-tRNA editing domain	-	-	-	ko:K03976	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
SX3_k127_1072432_0	744872.Spica_0658	1.342e-281	876.0	COG0008@1|root,COG0008@2|Bacteria,2J6KU@203691|Spirochaetes	203691|Spirochaetes	J	Glutaminyl-tRNA synthetase	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
SX3_k127_1072432_3	926550.CLDAP_34850	8.568e-102	339.0	COG0647@1|root,COG0647@2|Bacteria,2G60W@200795|Chloroflexi	200795|Chloroflexi	G	COGs COG0647 sugar phosphatase of the HAD superfamily	-	-	-	ko:K02566	-	-	-	-	ko00000	-	-	-	Hydrolase_6,Hydrolase_like
SX3_k127_1072432_1	570967.JMLV01000007_gene971	4.28e-167	542.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,2TT46@28211|Alphaproteobacteria,2JPDP@204441|Rhodospirillales	204441|Rhodospirillales	C	Catalyzes the reversible hydration of fumarate to (S)- malate	fumA	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
SX3_k127_1072432_9	172088.AUGA01000011_gene2673	1.841e-05	53.0	COG2020@1|root,COG2020@2|Bacteria,1RDC4@1224|Proteobacteria,2TUXA@28211|Alphaproteobacteria,3JU1Y@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
SX3_k127_1072432_8	641524.ADICYQ_0001	6.738e-08	65.0	COG1520@1|root,COG1520@2|Bacteria,4NK4X@976|Bacteroidetes,47KWI@768503|Cytophagia	976|Bacteroidetes	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1072432_10	709991.Odosp_0174	0.0004352	49.0	COG3666@1|root,COG3666@2|Bacteria,4NEDD@976|Bacteroidetes,2FNIQ@200643|Bacteroidia,22WUY@171551|Porphyromonadaceae	976|Bacteroidetes	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
SX3_k127_1072432_4	1263831.F543_22830	1.575e-92	320.0	COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria	1224|Proteobacteria	M	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
SX3_k127_1072432_6	794903.OPIT5_16195	2.012e-46	180.0	COG2253@1|root,COG2253@2|Bacteria	2|Bacteria	V	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
SX3_k127_1072432_2	744872.Spica_0319	6.061e-139	452.0	COG2114@1|root,COG2114@2|Bacteria,2J6ME@203691|Spirochaetes	203691|Spirochaetes	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
SX3_k127_107730_4	1047013.AQSP01000095_gene2314	6.73e-114	389.0	COG0001@1|root,COG0001@2|Bacteria,2NNV5@2323|unclassified Bacteria	2|Bacteria	H	PFAM aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3,NMO
SX3_k127_107730_7	1469245.JFBG01000083_gene221	4.412e-88	303.0	COG0350@1|root,COG2207@1|root,COG0350@2|Bacteria,COG2207@2|Bacteria,1N2YQ@1224|Proteobacteria,1RPR3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	FL	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ada	-	2.1.1.63	ko:K00567,ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	DNA_binding_1,HTH_18,Methyltransf_1N
SX3_k127_107730_5	1499967.BAYZ01000080_gene935	1.399e-100	348.0	COG5434@1|root,COG5434@2|Bacteria	2|Bacteria	M	polygalacturonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Pectate_lyase_3
SX3_k127_107730_8	1379698.RBG1_1C00001G0752	3.857e-46	179.0	COG2138@1|root,COG2138@2|Bacteria	2|Bacteria	S	sirohydrochlorin cobaltochelatase activity	cbiX	-	-	-	-	-	-	-	-	-	-	-	CbiX
SX3_k127_107730_6	313596.RB2501_15789	7.345e-89	301.0	COG0564@1|root,COG0564@2|Bacteria,4NFS8@976|Bacteroidetes,1HXBY@117743|Flavobacteriia	976|Bacteroidetes	J	Pseudouridine synthase	rluC	-	5.4.99.23,5.4.99.28,5.4.99.29	ko:K06177,ko:K06180	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	PseudoU_synth_2
SX3_k127_107730_11	1499967.BAYZ01000007_gene5398	1.113e-07	63.0	COG0697@1|root,COG0697@2|Bacteria,2NRZ5@2323|unclassified Bacteria	2|Bacteria	EG	spore germination	Z012_05125	-	-	-	-	-	-	-	-	-	-	-	EamA
SX3_k127_107730_1	886293.Sinac_0671	4.761e-135	438.0	COG0329@1|root,COG0329@2|Bacteria,2IXEF@203682|Planctomycetes	203682|Planctomycetes	EM	Belongs to the DapA family	-	-	-	-	-	-	-	-	-	-	-	-	DHDPS
SX3_k127_107730_2	1499967.BAYZ01000182_gene4467	1.331e-122	404.0	COG3181@1|root,COG3181@2|Bacteria	2|Bacteria	E	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
SX3_k127_107730_0	331869.BAL199_24904	2.961e-142	462.0	COG0673@1|root,COG0673@2|Bacteria,1NVJK@1224|Proteobacteria,2U0NE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	MA20_02630	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
SX3_k127_107730_3	886293.Sinac_0672	3.864e-119	394.0	COG0451@1|root,COG0451@2|Bacteria,2IXGI@203682|Planctomycetes	203682|Planctomycetes	GM	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
SX3_k127_107730_9	903814.ELI_0486	4.194e-43	175.0	COG5598@1|root,COG5598@2|Bacteria,1UY21@1239|Firmicutes,248BQ@186801|Clostridia	186801|Clostridia	H	PFAM Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
SX3_k127_107730_10	469383.Cwoe_0374	1.249e-08	59.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
SX3_k127_1082709_2	448385.sce5048	2.176e-115	376.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,4377A@68525|delta/epsilon subdivisions,2X27V@28221|Deltaproteobacteria,2YXVZ@29|Myxococcales	28221|Deltaproteobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SX3_k127_1082709_3	1184267.A11Q_2426	1.114e-13	83.0	COG3568@1|root,COG3568@2|Bacteria	2|Bacteria	N	Endonuclease Exonuclease Phosphatase	-	-	3.1.3.90,3.1.4.12	ko:K06896,ko:K12351	ko00500,ko00600,ko01100,ko04071,map00500,map00600,map01100,map04071	-	R02541,R10486	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	2_5_RNA_ligase2,CBM_21,Exo_endo_phos,PAP_central
SX3_k127_1082709_0	1321778.HMPREF1982_04262	2.089e-193	611.0	COG0205@1|root,COG0205@2|Bacteria,1TRJQ@1239|Firmicutes,247IV@186801|Clostridia,2688K@186813|unclassified Clostridiales	186801|Clostridia	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
SX3_k127_1082709_1	1230342.CTM_20481	1.752e-119	393.0	COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,36DT9@31979|Clostridiaceae	186801|Clostridia	V	Mate efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
SX3_k127_1083037_0	1499967.BAYZ01000171_gene5559	7.785e-111	362.0	COG0190@1|root,COG0190@2|Bacteria,2NNY1@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
SX3_k127_1126032_23	272626.lin2932	2.175e-44	172.0	COG0673@1|root,COG0673@2|Bacteria,1TQ72@1239|Firmicutes,4HDQA@91061|Bacilli,26M6X@186820|Listeriaceae	91061|Bacilli	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX3_k127_1126032_24	1293054.HSACCH_00981	5.376e-38	154.0	COG0395@1|root,COG0395@2|Bacteria,1V3Y9@1239|Firmicutes,25C5H@186801|Clostridia,3WBP0@53433|Halanaerobiales	186801|Clostridia	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX3_k127_1126032_21	118163.Ple7327_0810	3.847e-49	186.0	COG1175@1|root,COG1175@2|Bacteria,1G0YN@1117|Cyanobacteria,3VI3Y@52604|Pleurocapsales	1117|Cyanobacteria	G	PFAM Binding-protein-dependent transport system inner membrane component	ugpA	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX3_k127_1126032_18	1415756.JQMY01000001_gene1863	5.318e-52	200.0	COG1653@1|root,COG1653@2|Bacteria,1PF41@1224|Proteobacteria,2VD9U@28211|Alphaproteobacteria,2PFV8@252301|Oceanicola	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1
SX3_k127_1126032_16	656519.Halsa_0311	6.932e-79	271.0	COG1600@1|root,COG1600@2|Bacteria,1V0A3@1239|Firmicutes,249D6@186801|Clostridia,3WAB4@53433|Halanaerobiales	186801|Clostridia	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1126032_12	1499967.BAYZ01000022_gene238	1.17e-92	317.0	COG1879@1|root,COG1879@2|Bacteria	2|Bacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K02058,ko:K10559	ko02010,map02010	M00220,M00221	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.9	-	-	Peripla_BP_4
SX3_k127_1126032_2	1499967.BAYZ01000012_gene2459	4.591e-171	552.0	COG1129@1|root,COG1129@2|Bacteria,2NPR8@2323|unclassified Bacteria	2|Bacteria	G	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
SX3_k127_1126032_11	1499967.BAYZ01000012_gene2460	6.011e-99	335.0	COG1172@1|root,COG1172@2|Bacteria	2|Bacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
SX3_k127_1126032_15	1499967.BAYZ01000022_gene241	1.169e-82	287.0	COG1172@1|root,COG1172@2|Bacteria	2|Bacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
SX3_k127_1126032_0	1499967.BAYZ01000151_gene1684	1.724e-209	662.0	COG1069@1|root,COG1069@2|Bacteria	2|Bacteria	G	ribulokinase activity	-	-	-	-	-	-	-	-	-	-	-	-	FGGY_C,FGGY_N
SX3_k127_1126032_25	1382230.ASAP_1392	9.219e-15	80.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRMR@28211|Alphaproteobacteria,2JPRA@204441|Rhodospirillales	204441|Rhodospirillales	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhB	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,Transket_pyr,Transketolase_C
SX3_k127_1126032_9	391616.OA238_c39900	5.086e-108	366.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRFK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit	-	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
SX3_k127_1126032_8	926554.KI912674_gene2625	4.57e-108	359.0	COG1071@1|root,COG1071@2|Bacteria,1WMIN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Dehydrogenase E1 component	-	-	-	-	-	-	-	-	-	-	-	-	E1_dh
SX3_k127_1126032_4	1499967.BAYZ01000022_gene246	2.387e-160	511.0	COG2376@1|root,COG2376@2|Bacteria,2NQCP@2323|unclassified Bacteria	2|Bacteria	G	Dak1 domain	-	-	2.7.1.121,2.7.1.28,2.7.1.29,4.6.1.15	ko:K00863,ko:K05878,ko:K05879	ko00051,ko00561,ko00680,ko01100,ko01120,ko01200,ko04622,map00051,map00561,map00680,map01100,map01120,map01200,map04622	M00344	R01011,R01012,R01059	RC00002,RC00015,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Dak1,Dak2
SX3_k127_1126032_19	1499967.BAYZ01000022_gene247	7.982e-52	190.0	COG1461@1|root,COG1461@2|Bacteria	2|Bacteria	S	glycerone kinase activity	-	-	2.7.1.121	ko:K05879	ko00561,ko01100,map00561,map01100	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000	-	-	-	Dak2
SX3_k127_1126032_13	545694.TREPR_2504	4.756e-92	313.0	COG1131@1|root,COG1131@2|Bacteria,2J5JM@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_1126032_17	1480694.DC28_11230	3.07e-64	228.0	COG1277@1|root,COG1277@2|Bacteria,2J6H8@203691|Spirochaetes	203691|Spirochaetes	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	nosY2	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3,ABC2_membrane_4
SX3_k127_1126032_14	744872.Spica_1288	1.035e-91	329.0	COG3225@1|root,COG3225@2|Bacteria,2J6NB@203691|Spirochaetes	203691|Spirochaetes	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
SX3_k127_1126032_1	1499967.BAYZ01000022_gene237	3.992e-173	549.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SX3_k127_1126032_7	526218.Sterm_3749	7.772e-112	375.0	COG0434@1|root,COG0434@2|Bacteria	2|Bacteria	S	BtpA family	sgcQ	-	-	ko:K06971	-	-	-	-	ko00000	-	-	-	BtpA
SX3_k127_1126032_5	416591.Tlet_1422	1.111e-135	440.0	COG2309@1|root,COG2309@2|Bacteria,2GC5H@200918|Thermotogae	200918|Thermotogae	E	PFAM peptidase M29, aminopeptidase II	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
SX3_k127_1126032_3	416591.Tlet_1423	1.268e-160	522.0	COG1070@1|root,COG1070@2|Bacteria,2GCEX@200918|Thermotogae	200918|Thermotogae	G	Belongs to the FGGY kinase family	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
SX3_k127_1126032_20	717231.Flexsi_1520	1.565e-51	194.0	COG0483@1|root,COG0483@2|Bacteria,2GFCS@200930|Deferribacteres	200930|Deferribacteres	G	Inositol monophosphatase family	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
SX3_k127_1126032_26	1121946.AUAX01000033_gene5689	1.974e-13	80.0	COG0500@1|root,COG2226@2|Bacteria,2H9G5@201174|Actinobacteria,4DD8E@85008|Micromonosporales	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	pmtA	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
SX3_k127_1126032_10	552811.Dehly_1104	4.55e-102	351.0	COG1541@1|root,COG1541@2|Bacteria,2GAKM@200795|Chloroflexi,34CP4@301297|Dehalococcoidia	301297|Dehalococcoidia	H	GH3 auxin-responsive promoter	-	-	-	-	-	-	-	-	-	-	-	-	GH3
SX3_k127_1126032_22	552811.Dehly_0922	3.47e-48	196.0	COG4191@1|root,COG4191@2|Bacteria,2G7Y4@200795|Chloroflexi,34DMA@301297|Dehalococcoidia	301297|Dehalococcoidia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
SX3_k127_1138090_2	452637.Oter_1983	8.344e-129	425.0	COG1132@1|root,COG1132@2|Bacteria,46UY5@74201|Verrucomicrobia,3K7GK@414999|Opitutae	414999|Opitutae	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SX3_k127_1138090_3	1304885.AUEY01000005_gene892	5.578e-85	291.0	COG0598@1|root,COG0598@2|Bacteria,1RGGI@1224|Proteobacteria,42UX4@68525|delta/epsilon subdivisions,2WQYH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM Mg2 transporter protein CorA family protein	-	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
SX3_k127_1138090_9	1192034.CAP_8755	2.653e-35	143.0	COG0782@1|root,COG0782@2|Bacteria,1RAP0@1224|Proteobacteria,42UCT@68525|delta/epsilon subdivisions,2WPAW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus	greB	-	-	ko:K04760	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
SX3_k127_1138090_8	880073.Calab_0150	2.491e-38	157.0	COG1597@1|root,COG1597@2|Bacteria,2NQYH@2323|unclassified Bacteria	2|Bacteria	I	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
SX3_k127_1138090_11	644282.Deba_1107	1.51e-27	130.0	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,42S1J@68525|delta/epsilon subdivisions,2WP2S@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
SX3_k127_1138090_4	1382356.JQMP01000001_gene970	1.605e-68	254.0	COG3386@1|root,COG3386@2|Bacteria,2GBCX@200795|Chloroflexi,27YTS@189775|Thermomicrobia	189775|Thermomicrobia	G	SMP-30/Gluconolaconase/LRE-like region	-	-	-	ko:K14274	ko00040,map00040	-	R02427	RC00713	ko00000,ko00001,ko01000	-	-	-	SGL
SX3_k127_1138090_7	1121413.JMKT01000010_gene715	1.631e-40	163.0	COG0385@1|root,COG0385@2|Bacteria,1MUMM@1224|Proteobacteria,42RVU@68525|delta/epsilon subdivisions,2WNVU@28221|Deltaproteobacteria,2MA7N@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	SBF-like CPA transporter family (DUF4137)	-	-	-	ko:K14347	-	-	-	-	ko00000,ko02000,ko04147	2.A.93.1	-	-	SBF_like
SX3_k127_1138090_13	744872.Spica_0412	9.206e-13	73.0	2EMZY@1|root,33FN4@2|Bacteria,2J8Y2@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1138090_10	1030157.AFMP01000011_gene3752	1.101e-32	132.0	COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,2U6ZS@28211|Alphaproteobacteria,2K3Z2@204457|Sphingomonadales	204457|Sphingomonadales	K	Belongs to the Fur family	fur	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
SX3_k127_1138090_0	1125863.JAFN01000001_gene2640	1.744e-207	671.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42PVA@68525|delta/epsilon subdivisions,2WJ10@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	transporter of a GTP-driven Fe(2 ) uptake system	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
SX3_k127_1138090_5	1121918.ARWE01000001_gene1994	7.062e-54	212.0	COG1321@1|root,COG1918@1|root,COG1321@2|Bacteria,COG1918@2|Bacteria,1N3ZM@1224|Proteobacteria,42TUU@68525|delta/epsilon subdivisions,2WQ8Z@28221|Deltaproteobacteria,43TAJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	KP	PFAM iron dependent repressor	ideR	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,FeoA
SX3_k127_1138090_6	373903.Hore_15950	3.972e-48	182.0	COG0778@1|root,COG0778@2|Bacteria,1V49Q@1239|Firmicutes,24IH8@186801|Clostridia	186801|Clostridia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SX3_k127_1138090_15	1408423.JHYA01000008_gene15	0.0004549	53.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H26P@909932|Negativicutes	909932|Negativicutes	NT	Methyl-accepting chemotaxis protein signaling domain protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
SX3_k127_1138090_14	1156937.MFUM_690001	5.895e-06	55.0	2BFNX@1|root,329HD@2|Bacteria,46ZC6@74201|Verrucomicrobia,37GSZ@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1138090_1	1379698.RBG1_1C00001G0698	2.67e-164	527.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,2NNV3@2323|unclassified Bacteria	2|Bacteria	C	Malic enzyme, NAD binding domain	maeB	GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114	1.1.1.38,1.1.1.40,2.3.1.8	ko:K00027,ko:K00029,ko:K00625,ko:K13788	ko00430,ko00620,ko00640,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,ko02020,map00430,map00620,map00640,map00680,map00710,map00720,map01100,map01120,map01200,map02020	M00169,M00172,M00357,M00579	R00214,R00216,R00230,R00921	RC00004,RC00105,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1637	Malic_M,PTA_PTB,malic
SX3_k127_1138090_12	906968.Trebr_2510	2.427e-13	71.0	COG2373@1|root,COG2373@2|Bacteria,2J5M0@203691|Spirochaetes	203691|Spirochaetes	S	Alpha-2-macroglobulin family	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,Big_5,MG1
SX3_k127_1152411_7	330084.JNYZ01000051_gene8962	3.746e-68	250.0	COG0815@1|root,COG0815@2|Bacteria,2GP8X@201174|Actinobacteria,4EA3Z@85010|Pseudonocardiales	201174|Actinobacteria	M	Carbon-nitrogen hydrolase	-	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
SX3_k127_1152411_1	521045.Kole_0686	1.596e-136	447.0	COG4573@1|root,COG4573@2|Bacteria	2|Bacteria	G	galactitol metabolic process	kbaZ	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944	5.1.3.40	ko:K02775,ko:K16371,ko:K21622	ko00052,ko01100,ko02060,map00052,map01100,map02060	M00279	R01069,R05570,R11623	RC00017,RC00438,RC00439,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.5.1	-	iE2348C_1286.E2348C_2240,iECIAI1_1343.ECIAI1_3280,iECO111_1330.ECO111_2811,iECO26_1355.ECO26_3004,iYL1228.KPN_03547	Tagatose_6_P_K
SX3_k127_1152411_6	180332.JTGN01000010_gene4452	3.991e-101	338.0	COG0524@1|root,COG0524@2|Bacteria,1TRRY@1239|Firmicutes,24E4U@186801|Clostridia	186801|Clostridia	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
SX3_k127_1152411_4	1499967.BAYZ01000030_gene1191	4.241e-114	372.0	COG1129@1|root,COG1129@2|Bacteria,2NPR8@2323|unclassified Bacteria	2|Bacteria	G	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
SX3_k127_1152411_2	1499967.BAYZ01000030_gene1190	1.895e-125	411.0	COG4158@1|root,COG4158@2|Bacteria	2|Bacteria	T	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
SX3_k127_1152411_3	1499967.BAYZ01000030_gene1189	8.449e-115	382.0	COG4158@1|root,COG4158@2|Bacteria	2|Bacteria	T	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
SX3_k127_1152411_5	1499967.BAYZ01000030_gene1188	3.413e-112	378.0	COG1879@1|root,COG1879@2|Bacteria	2|Bacteria	G	ABC-type sugar transport system periplasmic component	rbsB	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
SX3_k127_1152411_8	398767.Glov_2226	4.577e-22	101.0	COG2050@1|root,COG2050@2|Bacteria,1N8F8@1224|Proteobacteria,42V78@68525|delta/epsilon subdivisions,2WRB4@28221|Deltaproteobacteria,43VHC@69541|Desulfuromonadales	28221|Deltaproteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
SX3_k127_1152411_0	1123288.SOV_1c08080	6.03e-149	483.0	COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,4H31M@909932|Negativicutes	909932|Negativicutes	C	Part of a membrane complex involved in electron transport	rnfC	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4,Fer4_10,Fer4_4,Fer4_8,RnfC_N,SLBB
SX3_k127_1152411_9	203119.Cthe_2431	1.789e-18	96.0	COG4658@1|root,COG4658@2|Bacteria,1TQAY@1239|Firmicutes,247TM@186801|Clostridia,3WGC0@541000|Ruminococcaceae	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
SX3_k127_1152647_3	1242864.D187_008136	9.822e-55	197.0	COG0371@1|root,COG0371@2|Bacteria,1NAAM@1224|Proteobacteria	1224|Proteobacteria	C	Glycerol dehydrogenase and related enzymes	egsA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
SX3_k127_1152647_0	1128421.JAGA01000002_gene1496	1.399e-140	458.0	COG3875@1|root,COG3875@2|Bacteria	2|Bacteria	S	lactate racemase activity	-	-	5.1.2.1	ko:K22373	ko00620,map00620	-	R01450	RC00519	ko00000,ko00001,ko01000	-	-	-	DUF2088
SX3_k127_1152647_1	401526.TcarDRAFT_2560	1.682e-116	394.0	2BXG3@1|root,2Z82R@2|Bacteria,1TQT7@1239|Firmicutes,4H6G6@909932|Negativicutes	909932|Negativicutes	S	tagaturonate epimerase	-	-	-	-	-	-	-	-	-	-	-	-	UxaE
SX3_k127_1152647_5	573413.Spirs_1683	1.037e-35	147.0	COG0546@1|root,COG0546@2|Bacteria	2|Bacteria	S	glycolate biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
SX3_k127_1152647_2	1191523.MROS_2095	5.867e-69	246.0	COG0646@1|root,COG0646@2|Bacteria	2|Bacteria	E	methionine synthase	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
SX3_k127_1152647_4	221027.JO40_09175	4.053e-37	155.0	COG0204@1|root,COG0204@2|Bacteria,2J6B7@203691|Spirochaetes	203691|Spirochaetes	I	Acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
SX3_k127_1152647_7	67332.FM21_17290	0.0001145	48.0	COG3415@1|root,COG3415@2|Bacteria,2IJ9E@201174|Actinobacteria	201174|Actinobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,HTH_32,HTH_33
SX3_k127_1152647_6	903818.KI912268_gene852	9.233e-19	89.0	COG2834@1|root,COG4249@1|root,COG2834@2|Bacteria,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	lolA	-	-	ko:K03634,ko:K14166	-	-	-	-	ko00000,ko02000	-	-	-	Cadherin,LolA,PPC,Peptidase_C14
SX3_k127_1159066_8	941449.dsx2_2931	1.767e-42	170.0	COG0477@1|root,COG2814@2|Bacteria,1P2GY@1224|Proteobacteria,42MWI@68525|delta/epsilon subdivisions,2WK29@28221|Deltaproteobacteria,2M97V@213115|Desulfovibrionales	28221|Deltaproteobacteria	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX3_k127_1159066_7	1480694.DC28_01005	5.12e-49	188.0	COG1597@1|root,COG1597@2|Bacteria,2J5GC@203691|Spirochaetes	203691|Spirochaetes	I	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
SX3_k127_1159066_5	573413.Spirs_1289	4.279e-59	216.0	COG0127@1|root,COG0127@2|Bacteria,2J7BY@203691|Spirochaetes	203691|Spirochaetes	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
SX3_k127_1159066_10	665571.STHERM_c05770	5.741e-20	103.0	2AMT3@1|root,31CPK@2|Bacteria,2J8CQ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1159066_4	545694.TREPR_3811	1.96e-79	278.0	COG0618@1|root,COG0618@2|Bacteria,2J6GG@203691|Spirochaetes	203691|Spirochaetes	S	DHH superfamily protein, subfamily 1	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
SX3_k127_1159066_2	545695.TREAZ_3136	1.611e-86	302.0	COG0006@1|root,COG0006@2|Bacteria,2J6QH@203691|Spirochaetes	203691|Spirochaetes	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
SX3_k127_1159066_9	573413.Spirs_1292	3.339e-27	116.0	29BJG@1|root,2ZG2E@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1159066_1	697303.Thewi_0603	1.121e-140	452.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,248I5@186801|Clostridia,42EK4@68295|Thermoanaerobacterales	186801|Clostridia	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3,2.1.3.9	ko:K00611,ko:K09065	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01398,R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
SX3_k127_1159066_0	555079.Toce_2001	1.933e-182	580.0	COG2403@1|root,COG2403@2|Bacteria,1TPZD@1239|Firmicutes,24E2D@186801|Clostridia,42HSE@68295|Thermoanaerobacterales	186801|Clostridia	S	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
SX3_k127_1159066_3	926569.ANT_20970	5.39e-83	287.0	COG1121@1|root,COG1121@2|Bacteria,2G7X2@200795|Chloroflexi	200795|Chloroflexi	P	PFAM ABC transporter related	-	-	-	ko:K09820,ko:K11710	ko02010,map02010	M00243,M00319	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15	-	-	ABC_tran
SX3_k127_1159066_6	760011.Spico_1850	2.714e-49	195.0	COG1820@1|root,COG1820@2|Bacteria,2J5F5@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	nagA	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
SX3_k127_1160759_0	522772.Dacet_0297	1.768e-47	194.0	COG4249@1|root,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	-	-	-	-	-	-	-	-	-	-	-	-	PPC,Peptidase_C14,TPR_8
SX3_k127_1160759_1	880073.Calab_0696	2.49e-43	181.0	COG1262@1|root,COG2911@1|root,COG3055@1|root,COG3934@1|root,COG5492@1|root,COG1262@2|Bacteria,COG2911@2|Bacteria,COG3055@2|Bacteria,COG3934@2|Bacteria,COG5492@2|Bacteria,2NPU7@2323|unclassified Bacteria	2|Bacteria	G	Sulfatase-modifying factor enzyme 1	-	-	3.2.1.1,3.2.1.51,3.2.1.78,3.2.1.81,3.2.1.89	ko:K01176,ko:K01206,ko:K01218,ko:K01219,ko:K01224	ko00051,ko00500,ko00511,ko01100,ko02024,ko04973,map00051,map00500,map00511,map01100,map02024,map04973	-	R01332,R02108,R02112,R11262	RC00467	ko00000,ko00001,ko01000,ko04147	-	GH13,GH26,GH29	-	Big_2,DctA-YdbH,FGE-sulfatase
SX3_k127_1160759_3	158190.SpiGrapes_0211	1.723e-06	55.0	COG0724@1|root,COG0724@2|Bacteria,2J8UF@203691|Spirochaetes	203691|Spirochaetes	S	PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
SX3_k127_1160799_0	522772.Dacet_0297	3.09e-47	193.0	COG4249@1|root,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	-	-	-	-	-	-	-	-	-	-	-	-	PPC,Peptidase_C14,TPR_8
SX3_k127_1160799_1	880073.Calab_0696	3.258e-43	180.0	COG1262@1|root,COG2911@1|root,COG3055@1|root,COG3934@1|root,COG5492@1|root,COG1262@2|Bacteria,COG2911@2|Bacteria,COG3055@2|Bacteria,COG3934@2|Bacteria,COG5492@2|Bacteria,2NPU7@2323|unclassified Bacteria	2|Bacteria	G	Sulfatase-modifying factor enzyme 1	-	-	3.2.1.1,3.2.1.51,3.2.1.78,3.2.1.81,3.2.1.89	ko:K01176,ko:K01206,ko:K01218,ko:K01219,ko:K01224	ko00051,ko00500,ko00511,ko01100,ko02024,ko04973,map00051,map00500,map00511,map01100,map02024,map04973	-	R01332,R02108,R02112,R11262	RC00467	ko00000,ko00001,ko01000,ko04147	-	GH13,GH26,GH29	-	Big_2,DctA-YdbH,FGE-sulfatase
SX3_k127_1160799_3	158190.SpiGrapes_0211	3.307e-08	55.0	COG0724@1|root,COG0724@2|Bacteria,2J8UF@203691|Spirochaetes	203691|Spirochaetes	S	PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
SX3_k127_1181960_3	883.DvMF_1428	3.749e-47	179.0	COG3884@1|root,COG3884@2|Bacteria,1NBT0@1224|Proteobacteria,42W3W@68525|delta/epsilon subdivisions,2WR9F@28221|Deltaproteobacteria,2MCDM@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	PFAM Acyl-ACP thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-ACP_TE
SX3_k127_1181960_2	1307761.L21SP2_3480	4.085e-78	298.0	COG0457@1|root,COG0457@2|Bacteria,2J7YH@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1181960_0	314285.KT71_17656	1.996e-125	419.0	COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,1RRXR@1236|Gammaproteobacteria,1JAET@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
SX3_k127_1181960_1	744872.Spica_1655	1.33e-82	286.0	COG2188@1|root,COG2188@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
SX3_k127_1181960_4	744872.Spica_1656	1.001e-28	126.0	COG2185@1|root,COG2185@2|Bacteria,2J83G@203691|Spirochaetes	203691|Spirochaetes	I	Catalyzes the carbon skeleton rearrangement of L- glutamate to L-threo-3-methylaspartate ((2S,3S)-3- methylaspartate)	mamA	-	5.4.99.1	ko:K01846	ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200	M00740	R00262	RC01221	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
SX3_k127_1196489_7	331678.Cphamn1_0569	1.167e-19	88.0	COG3657@1|root,COG3657@2|Bacteria	2|Bacteria	K	addiction module killer protein	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
SX3_k127_1196489_2	324925.Ppha_2273	2.87e-43	159.0	COG3636@1|root,COG3636@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
SX3_k127_1196489_4	1265505.ATUG01000002_gene1934	5.328e-28	117.0	COG3744@1|root,COG3744@2|Bacteria,1N349@1224|Proteobacteria,42TI4@68525|delta/epsilon subdivisions,2WR3M@28221|Deltaproteobacteria,2MM7Y@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
SX3_k127_1196489_15	1173024.KI912148_gene3737	0.000173	47.0	COG4118@1|root,COG4118@2|Bacteria,1G7T7@1117|Cyanobacteria,1JMD7@1189|Stigonemataceae	1117|Cyanobacteria	D	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
SX3_k127_1196489_6	1173026.Glo7428_2602	6.331e-22	99.0	COG4113@1|root,COG4113@2|Bacteria,1G71V@1117|Cyanobacteria	1117|Cyanobacteria	S	to nucleic acid-binding protein contains PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
SX3_k127_1196489_11	593750.Metfor_1045	4.257e-07	52.0	COG2361@1|root,arCOG05024@2157|Archaea	593750.Metfor_1045|-	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1196489_9	1255043.TVNIR_2919	2.456e-12	72.0	COG1669@1|root,COG1669@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
SX3_k127_1196489_5	1117318.PRUB_09164	1.305e-27	126.0	COG2706@1|root,COG4676@1|root,COG2706@2|Bacteria,COG4676@2|Bacteria,1MYHN@1224|Proteobacteria,1S7IE@1236|Gammaproteobacteria,2Q4PF@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	G	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1196489_16	1122221.JHVI01000017_gene2031	0.0002042	51.0	COG4710@1|root,COG4710@2|Bacteria,1WN3N@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	TraY domain	-	-	-	ko:K18918	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	RHH_1
SX3_k127_1196489_10	1125779.HMPREF1219_01713	1.082e-08	59.0	COG2026@1|root,COG2026@2|Bacteria	2|Bacteria	DJ	nuclease activity	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
SX3_k127_1196489_0	1125863.JAFN01000001_gene2828	2.305e-119	406.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,43AW1@68525|delta/epsilon subdivisions,2X6A7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
SX3_k127_1196489_14	1117647.M5M_07245	7.754e-05	53.0	COG0664@1|root,COG0664@2|Bacteria,1RKRH@1224|Proteobacteria,1S42Z@1236|Gammaproteobacteria,1JC0X@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
SX3_k127_1196489_3	635013.TherJR_2511	2.405e-38	166.0	COG3437@1|root,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia,260QX@186807|Peptococcaceae	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,GGDEF,HD,HD_5,PAS,PAS_4,PAS_9,dCache_1
SX3_k127_1196489_1	1125863.JAFN01000001_gene2828	5.039e-113	396.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,43AW1@68525|delta/epsilon subdivisions,2X6A7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
SX3_k127_1196489_13	1048983.EL17_12765	6.509e-06	56.0	COG3714@1|root,COG3714@2|Bacteria,4NMZ9@976|Bacteroidetes,47RZ2@768503|Cytophagia	976|Bacteroidetes	S	PFAM YhhN-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YhhN
SX3_k127_1196489_17	713587.THITH_05830	0.0002559	44.0	COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,1RRXR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ATPase, AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
SX3_k127_1196489_12	1306947.ARQD01000002_gene482	2.114e-06	51.0	COG1373@1|root,COG1373@2|Bacteria,2NPXS@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
SX3_k127_122108_3	1343740.M271_42450	6.993e-29	118.0	COG0111@1|root,COG0111@2|Bacteria,2GXN3@201174|Actinobacteria	201174|Actinobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
SX3_k127_122108_0	1343740.M271_42410	1.431e-90	312.0	COG2220@1|root,COG2220@2|Bacteria	2|Bacteria	S	N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Lactamase_B_3
SX3_k127_122108_2	1458275.AZ34_08275	2.09e-57	225.0	COG3386@1|root,COG3391@1|root,COG4783@1|root,COG3386@2|Bacteria,COG3391@2|Bacteria,COG4783@2|Bacteria,1R1XY@1224|Proteobacteria,2VX19@28216|Betaproteobacteria,4AJMH@80864|Comamonadaceae	28216|Betaproteobacteria	G	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL,TPR_2,TPR_8
SX3_k127_122108_4	1087481.AGFX01000048_gene2614	1.903e-07	65.0	COG0737@1|root,COG1361@1|root,COG3507@1|root,COG4733@1|root,COG0737@2|Bacteria,COG1361@2|Bacteria,COG3507@2|Bacteria,COG4733@2|Bacteria,1V7PQ@1239|Firmicutes,4IUC5@91061|Bacilli,277JF@186822|Paenibacillaceae	91061|Bacilli	G	Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,SLH,fn3
SX3_k127_122108_1	926550.CLDAP_17040	7.71e-73	276.0	COG5276@1|root,COG5276@2|Bacteria,2G8F2@200795|Chloroflexi	200795|Chloroflexi	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
SX3_k127_1229021_1	1183377.Py04_0849	8.323e-79	280.0	COG0119@1|root,arCOG02092@2157|Archaea,2XSZJ@28890|Euryarchaeota,242N6@183968|Thermococci	183968|Thermococci	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
SX3_k127_1229021_2	573413.Spirs_2284	6.008e-78	280.0	COG2843@1|root,COG2843@2|Bacteria,2J77A@203691|Spirochaetes	203691|Spirochaetes	M	Bacterial capsule synthesis protein	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
SX3_k127_1229021_4	929703.KE386491_gene1487	1.74e-05	59.0	COG0457@1|root,COG1729@1|root,COG4105@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,COG4105@2|Bacteria,4NE4W@976|Bacteroidetes,47JS4@768503|Cytophagia	976|Bacteroidetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_21,TPR_6,TPR_8
SX3_k127_1229021_0	565034.BHWA1_01228	1.883e-290	913.0	COG0542@1|root,COG0542@2|Bacteria,2J5B9@203691|Spirochaetes	203691|Spirochaetes	O	ATPase family associated with various cellular activities (AAA)	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
SX3_k127_125270_11	1200792.AKYF01000003_gene308	0.0001701	54.0	COG0772@1|root,COG0772@2|Bacteria,1V1V4@1239|Firmicutes,4HCZ8@91061|Bacilli,275AF@186822|Paenibacillaceae	91061|Bacilli	D	Cell cycle protein	-	-	-	-	-	-	-	-	-	-	-	-	FTSW_RODA_SPOVE
SX3_k127_125270_8	1321778.HMPREF1982_03176	4.844e-23	103.0	COG1695@1|root,COG1695@2|Bacteria,1VAKA@1239|Firmicutes,24MVF@186801|Clostridia	186801|Clostridia	K	transcriptional regulator, PadR family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
SX3_k127_125270_10	573413.Spirs_3350	1.214e-10	72.0	28X9U@1|root,2ZJ7V@2|Bacteria,2J87S@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_125270_6	1123274.KB899411_gene3193	4.377e-66	231.0	COG2236@1|root,COG2236@2|Bacteria,2JAE0@203691|Spirochaetes	203691|Spirochaetes	F	PFAM Phosphoribosyl transferase domain	-	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
SX3_k127_125270_5	177437.HRM2_06340	3.29e-110	381.0	COG1079@1|root,COG1079@2|Bacteria,1MVDQ@1224|Proteobacteria,42P6E@68525|delta/epsilon subdivisions,2WISH@28221|Deltaproteobacteria,2MHMZ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
SX3_k127_125270_4	177437.HRM2_06330	3.405e-137	450.0	COG4603@1|root,COG4603@2|Bacteria,1MX6V@1224|Proteobacteria,42QQQ@68525|delta/epsilon subdivisions,2WMBP@28221|Deltaproteobacteria,2MIM7@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
SX3_k127_125270_0	665571.STHERM_c19110	9.424e-182	586.0	COG3845@1|root,COG3845@2|Bacteria	2|Bacteria	P	ABC transporter	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
SX3_k127_125270_2	665571.STHERM_c19120	7.306e-167	535.0	COG1744@1|root,COG1744@2|Bacteria,2J7UH@203691|Spirochaetes	203691|Spirochaetes	S	Membrane protein, bmp family	-	-	-	ko:K02058,ko:K07335	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
SX3_k127_125270_9	879212.DespoDRAFT_01111	2.234e-18	85.0	arCOG07672@1|root,31TNR@2|Bacteria,1NYF2@1224|Proteobacteria,430G1@68525|delta/epsilon subdivisions,2WVYV@28221|Deltaproteobacteria,2MNKZ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4258)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4258
SX3_k127_125270_7	1047013.AQSP01000142_gene178	1.672e-23	101.0	2E4K0@1|root,32ZEZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_125270_1	573413.Spirs_1039	5.161e-178	567.0	COG0017@1|root,COG0017@2|Bacteria,2J73H@203691|Spirochaetes	203691|Spirochaetes	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	-	-	6.1.1.23	ko:K09759	ko00970,map00970	M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
SX3_k127_125270_3	1307761.L21SP2_3489	3.668e-142	470.0	COG0064@1|root,COG0064@2|Bacteria,2J58X@203691|Spirochaetes	203691|Spirochaetes	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
SX3_k127_127915_1	158190.SpiGrapes_1981	1.338e-46	184.0	COG0642@1|root,COG1609@1|root,COG2207@1|root,COG1609@2|Bacteria,COG2205@2|Bacteria,COG2207@2|Bacteria,2J67C@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory helix-turn-helix proteins, AraC family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,Peripla_BP_3
SX3_k127_127915_2	525904.Tter_2603	3.817e-24	115.0	COG0673@1|root,COG0673@2|Bacteria,2NR8T@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX3_k127_127915_0	945713.IALB_3103	8.036e-105	350.0	COG1313@1|root,COG1313@2|Bacteria	2|Bacteria	C	radical SAM domain protein	PflX	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
SX3_k127_127915_3	192952.MM_2928	2.081e-23	99.0	arCOG01917@1|root,arCOG01917@2157|Archaea	2157|Archaea	M	deoxyhypusine monooxygenase activity	-	-	4.1.3.36	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07263	RC01923	ko00000,ko00001,ko00002,ko01000	-	-	-	DZR,ECH_1,FHA,zf-ribbon_3,zinc_ribbon_2
SX3_k127_1284057_0	545695.TREAZ_0275	4.181e-71	253.0	COG2265@1|root,COG2265@2|Bacteria,2J5Y7@203691|Spirochaetes	203691|Spirochaetes	H	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	ygcA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
SX3_k127_145750_3	189426.PODO_25000	5.086e-45	171.0	COG1653@1|root,COG1653@2|Bacteria,1V0BA@1239|Firmicutes,4HUU2@91061|Bacilli,26TPH@186822|Paenibacillaceae	91061|Bacilli	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8
SX3_k127_145750_4	717605.Theco_0855	2.259e-41	169.0	COG2169@1|root,COG4753@1|root,COG2169@2|Bacteria,COG4753@2|Bacteria,1UMK7@1239|Firmicutes,4H9QN@91061|Bacilli,26SPJ@186822|Paenibacillaceae	91061|Bacilli	T	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
SX3_k127_145750_2	1122927.KB895413_gene1949	3.343e-58	224.0	COG2972@1|root,COG2972@2|Bacteria,1TSQR@1239|Firmicutes,4I7AG@91061|Bacilli,26WAA@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,His_kinase
SX3_k127_145750_0	204669.Acid345_4432	4.823e-153	506.0	COG2203@1|root,COG2206@1|root,COG3437@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,COG3437@2|Bacteria,3Y61X@57723|Acidobacteria	57723|Acidobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HD_5
SX3_k127_145750_1	744872.Spica_2854	5.978e-90	319.0	COG0457@1|root,COG1305@1|root,COG0457@2|Bacteria,COG1305@2|Bacteria,2J681@203691|Spirochaetes	203691|Spirochaetes	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_7,TPR_8,Transglut_core
SX3_k127_145750_5	545694.TREPR_0180	1.7e-29	127.0	COG1305@1|root,COG1305@2|Bacteria,2J681@203691|Spirochaetes	203691|Spirochaetes	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_7,TPR_8,Transglut_core
SX3_k127_148820_0	1297569.MESS2_50083	6.072e-150	503.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TWBA@28211|Alphaproteobacteria,43MU4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.4	ko:K11381,ko:K21416	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,E1_dh,Transket_pyr,Transketolase_C
SX3_k127_148820_1	643648.Slip_2310	2.724e-71	252.0	COG0191@1|root,COG0191@2|Bacteria,1TQ01@1239|Firmicutes,248B7@186801|Clostridia,42JJR@68298|Syntrophomonadaceae	186801|Clostridia	G	Fructose-bisphosphate aldolase class-II	fba	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
SX3_k127_148820_2	573413.Spirs_0818	7.134e-21	99.0	COG0645@1|root,COG0645@2|Bacteria,2JAKZ@203691|Spirochaetes	203691|Spirochaetes	S	AAA domain	-	-	2.7.1.25	ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	M00176	R00509,R04928	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_33
SX3_k127_1539195_6	1499967.BAYZ01000171_gene5560	1.774e-24	115.0	COG1148@1|root,COG1148@2|Bacteria	2|Bacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_oxidored,Fer4,Fer4_4,Fer4_6,Fer4_7,FlpD,NAD_binding_8,Pyr_redox_2
SX3_k127_1539195_0	1499967.BAYZ01000171_gene5560	1.637e-105	356.0	COG1148@1|root,COG1148@2|Bacteria	2|Bacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_oxidored,Fer4,Fer4_4,Fer4_6,Fer4_7,FlpD,NAD_binding_8,Pyr_redox_2
SX3_k127_1539195_4	373903.Hore_15370	3.573e-35	150.0	COG2207@1|root,COG4936@1|root,COG2207@2|Bacteria,COG4936@2|Bacteria,1U23Q@1239|Firmicutes,24CZ9@186801|Clostridia,3WBEQ@53433|Halanaerobiales	186801|Clostridia	K	containing protein AraC type	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_18,HTH_AraC,PocR
SX3_k127_1539195_1	1125699.HMPREF9194_00555	7.086e-92	315.0	COG0524@1|root,COG0524@2|Bacteria,2JA75@203691|Spirochaetes	203691|Spirochaetes	G	COGs COG0524 Sugar kinase ribokinase family	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
SX3_k127_1539195_2	1280953.HOC_20148	4.646e-76	268.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2TSYI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Phosphate	pit	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
SX3_k127_1539195_3	706587.Desti_4215	4.281e-50	186.0	COG1392@1|root,COG1392@2|Bacteria,1NDTG@1224|Proteobacteria	1224|Proteobacteria	P	phosphate transport regulator (Distant homolog of PhoU)	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
SX3_k127_1539195_5	1499967.BAYZ01000095_gene4292	1.721e-32	129.0	COG0524@1|root,COG0524@2|Bacteria	2|Bacteria	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	-	-	2.7.1.15,2.7.1.20,2.7.1.213,2.7.1.218,2.7.1.73	ko:K00852,ko:K00856,ko:K10710,ko:K22026	ko00030,ko00230,ko00240,ko01100,map00030,map00230,map00240,map01100	-	R00185,R00513,R01051,R01131,R01228,R02750,R08124	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
SX3_k127_1543851_1	472759.Nhal_0131	9.578e-84	283.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RQ0G@1236|Gammaproteobacteria,1WXEX@135613|Chromatiales	135613|Chromatiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
SX3_k127_1543851_0	926560.KE387023_gene3394	1.37e-103	349.0	COG0477@1|root,COG2814@2|Bacteria,1WKZT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX3_k127_1543851_3	1380355.JNIJ01000048_gene33	1.307e-08	60.0	2AHTU@1|root,3186F@2|Bacteria,1NN1Q@1224|Proteobacteria,2UTGK@28211|Alphaproteobacteria,3K4KG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
SX3_k127_1543851_2	545694.TREPR_3723	2.754e-20	97.0	COG1848@1|root,COG1848@2|Bacteria,2JAPG@203691|Spirochaetes	203691|Spirochaetes	S	Large family of predicted nucleotide-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	PIN
SX3_k127_1602616_25	545694.TREPR_2780	7.162e-46	179.0	COG0457@1|root,COG1652@1|root,COG0457@2|Bacteria,COG1652@2|Bacteria,2J7YH@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1602616_16	331113.SNE_A22970	3.715e-80	282.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	-	-	-	-	-	-	-	-	-	AAA_14,DUF4143
SX3_k127_1602616_37	906968.Trebr_2139	2.583e-18	100.0	COG1186@1|root,COG1186@2|Bacteria,2J8DU@203691|Spirochaetes	203691|Spirochaetes	J	PFAM Class I peptide chain release factor	-	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
SX3_k127_1602616_13	744872.Spica_0734	1.847e-96	341.0	COG0642@1|root,COG2205@2|Bacteria,2J63U@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
SX3_k127_1602616_17	744872.Spica_0733	2.25e-79	271.0	COG0745@1|root,COG0745@2|Bacteria,2J7CF@203691|Spirochaetes	203691|Spirochaetes	K	COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SX3_k127_1602616_6	264462.Bd0709	2.492e-162	551.0	COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,4308T@68525|delta/epsilon subdivisions,2MTI3@213481|Bdellovibrionales,2X727@28221|Deltaproteobacteria	213481|Bdellovibrionales	V	membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K02003,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
SX3_k127_1602616_32	352165.HMPREF7215_2152	4.959e-26	123.0	COG0845@1|root,COG0845@2|Bacteria,3T9UB@508458|Synergistetes	508458|Synergistetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
SX3_k127_1602616_35	891968.Anamo_2024	1.115e-22	113.0	COG1538@1|root,COG1538@2|Bacteria,3TAY7@508458|Synergistetes	508458|Synergistetes	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
SX3_k127_1602616_7	1121396.KB893013_gene3675	3.349e-121	401.0	COG0863@1|root,COG0863@2|Bacteria,1R7RV@1224|Proteobacteria,42NFT@68525|delta/epsilon subdivisions,2WJMQ@28221|Deltaproteobacteria,2MJ40@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
SX3_k127_1602616_36	349124.Hhal_0141	2.053e-19	98.0	COG4244@1|root,COG4244@2|Bacteria	2|Bacteria	E	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231,Fn3_assoc,PSCyt1,PSCyt2,PSD1
SX3_k127_1602616_8	545695.TREAZ_3436	1.673e-119	398.0	COG0613@1|root,COG0613@2|Bacteria,2J6D0@203691|Spirochaetes	203691|Spirochaetes	S	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1602616_19	1307761.L21SP2_3108	1.676e-63	240.0	2C3NG@1|root,348TB@2|Bacteria,2J5WS@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Caps_assemb_Wzi
SX3_k127_1602616_20	56107.Cylst_0426	3.636e-61	239.0	COG0823@1|root,COG5276@1|root,COG0823@2|Bacteria,COG5276@2|Bacteria,1GQ7S@1117|Cyanobacteria,1HRXM@1161|Nostocales	1117|Cyanobacteria	Q	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,DUF4347,HemolysinCabind,LVIVD
SX3_k127_1602616_22	1458275.AZ34_08275	4.925e-56	222.0	COG3386@1|root,COG3391@1|root,COG4783@1|root,COG3386@2|Bacteria,COG3391@2|Bacteria,COG4783@2|Bacteria,1R1XY@1224|Proteobacteria,2VX19@28216|Betaproteobacteria,4AJMH@80864|Comamonadaceae	28216|Betaproteobacteria	G	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL,TPR_2,TPR_8
SX3_k127_1602616_23	316274.Haur_0067	5.985e-54	200.0	COG3315@1|root,COG3315@2|Bacteria,2GAE5@200795|Chloroflexi,375R6@32061|Chloroflexia	32061|Chloroflexia	Q	S-adenosyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_19
SX3_k127_1602616_12	706587.Desti_3021	2.016e-99	349.0	COG2202@1|root,COG2204@1|root,COG3850@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2204@2|Bacteria,COG3850@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIU5@28221|Deltaproteobacteria,2MQZQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
SX3_k127_1602616_3	889378.Spiaf_2634	2.762e-262	824.0	COG0326@1|root,COG0326@2|Bacteria,2J6JQ@203691|Spirochaetes	203691|Spirochaetes	F	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c_3,HSP90
SX3_k127_1602616_38	1121479.AUBS01000001_gene3188	3.769e-18	92.0	2CA4Z@1|root,32W4Q@2|Bacteria,1N3RF@1224|Proteobacteria,2UDC8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1602616_9	1379698.RBG1_1C00001G1660	4.322e-119	392.0	COG4867@1|root,COG4867@2|Bacteria,2NQZ8@2323|unclassified Bacteria	2|Bacteria	S	von Willebrand factor (vWF) type A domain	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA_2
SX3_k127_1602616_4	518766.Rmar_2682	1.625e-177	571.0	COG1239@1|root,COG1239@2|Bacteria,4NF1J@976|Bacteroidetes,1FIU1@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	H	magnesium chelatase	chlI	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	AAA_5,Sigma54_activat
SX3_k127_1602616_28	1499967.BAYZ01000089_gene4993	5.678e-32	145.0	COG0859@1|root,COG0859@2|Bacteria	2|Bacteria	M	ADP-heptose-lipopolysaccharide heptosyltransferase activity	-	-	-	ko:K02843,ko:K02849	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
SX3_k127_1602616_5	903818.KI912269_gene455	3.04e-173	552.0	COG0282@1|root,COG0282@2|Bacteria,3Y6AP@57723|Acidobacteria	2|Bacteria	C	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0409	Acetate_kinase
SX3_k127_1602616_26	880072.Desac_1571	6.121e-41	171.0	COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,42SGH@68525|delta/epsilon subdivisions,2WP2B@28221|Deltaproteobacteria,2MQIF@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1897	PRA-CH,PRA-PH
SX3_k127_1602616_10	880072.Desac_1572	8.839e-115	380.0	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,42N9N@68525|delta/epsilon subdivisions,2WIY9@28221|Deltaproteobacteria,2MQ6C@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	ATP phosphoribosyltransferase	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
SX3_k127_1602616_1	926569.ANT_31250	4.394e-310	975.0	COG0474@1|root,COG0474@2|Bacteria,2G5ZS@200795|Chloroflexi	200795|Chloroflexi	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
SX3_k127_1602616_27	1382358.JHVN01000014_gene1636	1.537e-40	171.0	COG0262@1|root,COG0262@2|Bacteria,1VB80@1239|Firmicutes,4HIGJ@91061|Bacilli,21W29@150247|Anoxybacillus	91061|Bacilli	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	dfrA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
SX3_k127_1602616_15	760011.Spico_0166	9.503e-92	335.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
SX3_k127_1602616_31	111780.Sta7437_1384	2.656e-26	112.0	COG1487@1|root,COG1487@2|Bacteria,1G7CX@1117|Cyanobacteria	1117|Cyanobacteria	S	COGs COG1487 nucleic acid-binding protein contains PIN domain	-	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
SX3_k127_1602616_43	1539298.JO41_10495	6.23e-07	55.0	29FCI@1|root,302A7@2|Bacteria,2J849@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1602616_33	290317.Cpha266_0290	2.181e-25	109.0	COG5304@1|root,COG5304@2|Bacteria,1FFGD@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1602616_30	396588.Tgr7_3294	4.225e-30	121.0	COG2929@1|root,COG2929@2|Bacteria,1N8PW@1224|Proteobacteria,1SAU5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Ribonuclease toxin, BrnT, of type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	BrnT_toxin
SX3_k127_1602616_18	1307761.L21SP2_0468	6.046e-64	231.0	COG0745@1|root,COG0745@2|Bacteria,2J7CK@203691|Spirochaetes	203691|Spirochaetes	K	COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K07657,ko:K18941	ko02020,map02020	M00434,M00716,M00717	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SX3_k127_1602616_39	880073.Calab_2437	7.268e-16	90.0	COG0265@1|root,COG0265@2|Bacteria,2NNVS@2323|unclassified Bacteria	2|Bacteria	O	smart pdz dhr glgf	htrA	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_1,PDZ_2,Trypsin_2
SX3_k127_1602616_42	66869.JNXG01000001_gene3957	4.487e-07	62.0	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,418H7@629295|Streptomyces griseus group	201174|Actinobacteria	O	Domain present in PSD-95, Dlg, and ZO-1/2.	sprI	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
SX3_k127_1602616_24	1121422.AUMW01000013_gene1511	2.699e-51	201.0	COG0642@1|root,COG2205@2|Bacteria,1V10X@1239|Firmicutes,24P7E@186801|Clostridia,260UH@186807|Peptococcaceae	186801|Clostridia	T	Histidine kinase	-	-	2.7.13.3	ko:K10681	ko02020,map02020	M00468	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
SX3_k127_1602616_0	404380.Gbem_1577	0.0	1357.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,42Q75@68525|delta/epsilon subdivisions,2WMDY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DEAD DEAH box	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
SX3_k127_1602616_34	52598.EE36_04798	7.047e-25	119.0	COG4783@1|root,COG4783@2|Bacteria,1QV70@1224|Proteobacteria,2TWBV@28211|Alphaproteobacteria,3ZZDG@60136|Sulfitobacter	28211|Alphaproteobacteria	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
SX3_k127_1602616_29	643867.Ftrac_1681	1.609e-30	130.0	2CK4K@1|root,32QTB@2|Bacteria,4NQUN@976|Bacteroidetes,47WRQ@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4870)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4870
SX3_k127_1602616_21	643867.Ftrac_1682	7.164e-58	211.0	29X2E@1|root,30IQW@2|Bacteria,4P919@976|Bacteroidetes,47WI2@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
SX3_k127_1602616_41	177437.HRM2_25970	5.653e-12	78.0	COG3271@1|root,COG3608@1|root,COG3271@2|Bacteria,COG3608@2|Bacteria,1QUH0@1224|Proteobacteria,43DZK@68525|delta/epsilon subdivisions,2X74A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF2817)	-	-	-	-	-	-	-	-	-	-	-	-	AstE_AspA
SX3_k127_1602616_11	404589.Anae109_1511	1.181e-103	352.0	COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,42P1M@68525|delta/epsilon subdivisions,2WKJ2@28221|Deltaproteobacteria,2Z11I@29|Myxococcales	28221|Deltaproteobacteria	M	CAAX prenyl protease N-terminal, five membrane helices	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
SX3_k127_1602616_2	1304880.JAGB01000002_gene1773	6.891e-277	871.0	COG1874@1|root,COG1874@2|Bacteria,1TQN6@1239|Firmicutes,2488V@186801|Clostridia	186801|Clostridia	G	beta-galactosidase	pbg	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_42,Glyco_hydro_42C,Glyco_hydro_42M
SX3_k127_1602616_14	1236976.JCM16418_1702	9.347e-95	316.0	COG0395@1|root,COG0395@2|Bacteria,1TPIF@1239|Firmicutes,4HE61@91061|Bacilli,26Q9R@186822|Paenibacillaceae	91061|Bacilli	P	Sugar ABC transporter ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
SX3_k127_16288_4	906968.Trebr_1764	8.924e-47	186.0	COG2604@1|root,COG2604@2|Bacteria,2J5F2@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF115	-	-	-	-	-	-	-	-	-	-	-	-	MAF_flag10
SX3_k127_16288_1	744872.Spica_0808	1.413e-84	301.0	COG0760@1|root,COG0760@2|Bacteria,2J720@203691|Spirochaetes	203691|Spirochaetes	O	PFAM PPIC-type PPIASE domain	-	-	-	-	-	-	-	-	-	-	-	-	Rotamase,Rotamase_2,SurA_N_2,SurA_N_3
SX3_k127_16288_3	1480694.DC28_11040	1.05e-66	243.0	2F58Y@1|root,33XV6@2|Bacteria,2J6V5@203691|Spirochaetes	203691|Spirochaetes	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
SX3_k127_16288_0	889378.Spiaf_2017	8.14e-111	382.0	COG1078@1|root,COG1078@2|Bacteria,2J64T@203691|Spirochaetes	203691|Spirochaetes	S	HD superfamily phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HD
SX3_k127_16288_2	573413.Spirs_2353	2.95e-70	249.0	COG0037@1|root,COG0037@2|Bacteria,2J61I@203691|Spirochaetes	203691|Spirochaetes	H	Belongs to the TtcA family	-	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
SX3_k127_16288_5	401053.AciPR4_3505	5.351e-46	186.0	COG0639@1|root,COG0639@2|Bacteria,3Y3U2@57723|Acidobacteria,2JIPQ@204432|Acidobacteriia	204432|Acidobacteriia	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
SX3_k127_16288_7	744872.Spica_1490	1.31e-28	117.0	COG1550@1|root,COG1550@2|Bacteria,2J8FX@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF503)	-	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
SX3_k127_163621_2	986075.CathTA2_1101	3.184e-44	169.0	COG1296@1|root,COG1296@2|Bacteria,1TSXD@1239|Firmicutes,4HCET@91061|Bacilli	91061|Bacilli	E	branched-chain amino acid	ygaZ	-	-	-	-	-	-	-	-	-	-	-	AzlC
SX3_k127_163621_4	1121929.KB898675_gene2180	9.381e-20	92.0	COG4392@1|root,COG4392@2|Bacteria,1VBUN@1239|Firmicutes,4HKJZ@91061|Bacilli,4712E@74385|Gracilibacillus	91061|Bacilli	S	Branched-chain amino acid transport protein (AzlD)	-	-	-	-	-	-	-	-	-	-	-	-	AzlD
SX3_k127_163621_3	904296.HMPREF9124_2045	6.639e-22	96.0	29YAU@1|root,30K50@2|Bacteria,1U57K@1239|Firmicutes,259FX@186801|Clostridia,2PTQB@265975|Oribacterium	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_163621_5	869209.Tresu_0528	1.024e-19	92.0	2E9Z3@1|root,3344K@2|Bacteria,2J8SH@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_163621_1	744872.Spica_1075	1.408e-48	188.0	COG2304@1|root,COG2304@2|Bacteria,2J874@203691|Spirochaetes	203691|Spirochaetes	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_163621_0	744872.Spica_1067	1.961e-148	533.0	COG1196@1|root,COG3210@1|root,COG1196@2|Bacteria,COG3210@2|Bacteria,2J8QW@203691|Spirochaetes	203691|Spirochaetes	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1638369_3	545695.TREAZ_2703	9.953e-78	266.0	COG1842@1|root,COG1842@2|Bacteria,2J5MH@203691|Spirochaetes	203691|Spirochaetes	KT	Phage shock protein A	-	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
SX3_k127_1638369_7	1123274.KB899407_gene358	2.662e-15	84.0	COG0745@1|root,COG0745@2|Bacteria	1123274.KB899407_gene358|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1638369_0	428125.CLOLEP_00103	2.305e-249	792.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,3WHVU@541000|Ruminococcaceae	186801|Clostridia	C	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
SX3_k127_1638369_6	545695.TREAZ_2700	3.642e-20	107.0	2BYRX@1|root,2ZIX1@2|Bacteria,2J60M@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1638369_4	1125863.JAFN01000001_gene1803	7.47e-37	150.0	COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,42STV@68525|delta/epsilon subdivisions,2WKKA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Tellurite resistance protein TerB	-	-	-	ko:K05801	-	-	-	-	ko00000,ko03110	-	-	-	DnaJ,TerB
SX3_k127_1638369_5	744872.Spica_0661	4.545e-24	109.0	2ANXJ@1|root,31DYA@2|Bacteria,2JB64@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1638369_2	1047013.AQSP01000114_gene692	2.828e-93	314.0	COG0384@1|root,COG0384@2|Bacteria,2NR2U@2323|unclassified Bacteria	2|Bacteria	S	Phenazine biosynthesis-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
SX3_k127_1638369_1	573413.Spirs_0147	8.045e-160	509.0	COG0766@1|root,COG0766@2|Bacteria,2J5JB@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
SX3_k127_1697716_0	1123274.KB899430_gene1685	5.786e-305	945.0	COG0466@1|root,COG0466@2|Bacteria,2J5CV@203691|Spirochaetes	203691|Spirochaetes	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
SX3_k127_1697716_3	573413.Spirs_3789	1.039e-60	228.0	COG1876@1|root,COG1876@2|Bacteria,2J72U@203691|Spirochaetes	203691|Spirochaetes	M	Carboxypeptidase	-	-	3.4.17.14	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	VanY
SX3_k127_1697716_4	1123274.KB899421_gene1719	1.033e-44	170.0	COG0009@1|root,COG0009@2|Bacteria,2J7KX@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the SUA5 family	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
SX3_k127_1697716_9	243233.MCA2516	0.0004761	48.0	COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,1SD8H@1236|Gammaproteobacteria,1XFRY@135618|Methylococcales	135618|Methylococcales	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsB	-	-	ko:K05589	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
SX3_k127_1697716_6	665571.STHERM_c14800	5.848e-27	127.0	2FFB7@1|root,3478X@2|Bacteria,2J8CB@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1697716_8	754027.HMPREF9554_02964	9.106e-05	54.0	29YNA@1|root,30KHU@2|Bacteria,2J8IV@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1697716_5	906968.Trebr_1522	2.786e-36	156.0	COG2604@1|root,COG2604@2|Bacteria,2J5AX@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF115	-	-	-	-	-	-	-	-	-	-	-	-	MAF_flag10
SX3_k127_1697716_1	1123274.KB899415_gene2542	2.166e-117	398.0	COG2604@1|root,COG2604@2|Bacteria,2J5FD@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF115	-	-	-	-	-	-	-	-	-	-	-	-	MAF_flag10
SX3_k127_1697716_2	880072.Desac_1616	4.335e-68	241.0	COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,42R55@68525|delta/epsilon subdivisions,2WKKG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
SX3_k127_1697716_7	889378.Spiaf_1430	5.093e-09	68.0	COG2199@1|root,COG2199@2|Bacteria	2|Bacteria	T	diguanylate cyclase activity	-	-	2.7.7.65	ko:K02065,ko:K21023	ko02010,ko02025,map02010,map02025	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.27	-	-	7TMR-DISMED2,7TMR-DISM_7TM,EAL,GGDEF,HlyD_D23,PAS_9,Response_reg
SX3_k127_1699686_9	177437.HRM2_25740	1.501e-129	426.0	COG1653@1|root,COG1653@2|Bacteria,1N98V@1224|Proteobacteria	1224|Proteobacteria	G	Extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
SX3_k127_1699686_18	545695.TREAZ_2083	6.823e-94	317.0	COG1175@1|root,COG1175@2|Bacteria,2J5SW@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX3_k127_1699686_20	545695.TREAZ_2084	1.566e-87	297.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	-	-	-	ko:K02026,ko:K17317	ko02010,map02010	M00207,M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.24,3.A.1.1.30	-	-	BPD_transp_1
SX3_k127_1699686_21	401526.TcarDRAFT_0365	1.326e-85	293.0	COG0280@1|root,COG0280@2|Bacteria,1TRQU@1239|Firmicutes,4H2DY@909932|Negativicutes	909932|Negativicutes	C	Phosphate acetyl/butaryl transferase	-	-	-	-	-	-	-	-	-	-	-	-	PTA_PTB
SX3_k127_1699686_4	1009370.ALO_04306	1.226e-150	488.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,4H2JV@909932|Negativicutes	909932|Negativicutes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
SX3_k127_1699686_22	665571.STHERM_c21540	3.081e-82	280.0	COG1028@1|root,COG1028@2|Bacteria,2J6CJ@203691|Spirochaetes	203691|Spirochaetes	IQ	PFAM Short-chain dehydrogenase reductase SDR	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SX3_k127_1699686_16	665571.STHERM_c21550	1.271e-95	322.0	COG0331@1|root,COG0331@2|Bacteria,2J5E6@203691|Spirochaetes	203691|Spirochaetes	I	Malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
SX3_k127_1699686_12	889378.Spiaf_0246	1.239e-113	376.0	COG0332@1|root,COG0332@2|Bacteria,2J6DC@203691|Spirochaetes	203691|Spirochaetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
SX3_k127_1699686_29	1122962.AULH01000019_gene316	4.019e-47	178.0	COG2020@1|root,COG2020@2|Bacteria,1R7G6@1224|Proteobacteria,2VG1Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
SX3_k127_1699686_25	911045.PSE_p0066	1.289e-64	233.0	COG1879@1|root,COG1879@2|Bacteria,1MWGU@1224|Proteobacteria,2U2E3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	ABC-type sugar transport system periplasmic component	mocB1	-	-	ko:K10439,ko:K17213	ko02010,ko02030,map02010,map02030	M00212,M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
SX3_k127_1699686_2	926550.CLDAP_26210	1.044e-174	562.0	COG1129@1|root,COG1129@2|Bacteria	2|Bacteria	G	ABC transporter	mglA_1	-	3.6.3.17	ko:K10441,ko:K17215	ko02010,map02010	M00212,M00593	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
SX3_k127_1699686_19	1122915.AUGY01000056_gene7	2.76e-93	319.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,4H9Y3@91061|Bacilli,26R5U@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the binding-protein-dependent transport system permease family	rbsC	-	-	ko:K17214	ko02010,map02010	M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
SX3_k127_1699686_10	243275.TDE_2405	1.624e-124	417.0	COG0312@1|root,COG0312@2|Bacteria,2J6GP@203691|Spirochaetes	203691|Spirochaetes	S	Putative modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
SX3_k127_1699686_3	754027.HMPREF9554_02911	3.572e-156	507.0	COG0312@1|root,COG0312@2|Bacteria,2J6S1@203691|Spirochaetes	203691|Spirochaetes	S	Putative modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
SX3_k127_1699686_38	477974.Daud_0415	1.808e-10	66.0	COG2402@1|root,COG2402@2|Bacteria	2|Bacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07065	-	-	-	-	ko00000	-	-	-	PIN
SX3_k127_1699686_14	1499967.BAYZ01000119_gene3205	1.845e-108	361.0	COG1609@1|root,COG1609@2|Bacteria,2NPGW@2323|unclassified Bacteria	2|Bacteria	K	PFAM Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
SX3_k127_1699686_17	1499967.BAYZ01000119_gene3198	3.178e-95	332.0	COG1879@1|root,COG1879@2|Bacteria	2|Bacteria	G	ABC-type sugar transport system periplasmic component	rbsB	-	-	ko:K10439,ko:K17208	ko02010,ko02030,map02010,map02030	M00212,M00592	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.21	-	-	Peripla_BP_4
SX3_k127_1699686_7	1009370.ALO_16172	1.263e-141	469.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,4H2EG@909932|Negativicutes	909932|Negativicutes	G	ABC transporter	-	-	-	ko:K17215	ko02010,map02010	M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2	-	-	ABC_tran
SX3_k127_1699686_15	1499967.BAYZ01000119_gene3192	6.018e-108	375.0	COG1172@1|root,COG1172@2|Bacteria,2NPUE@2323|unclassified Bacteria	2|Bacteria	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
SX3_k127_1699686_0	1434325.AZQN01000015_gene1376	5.627e-201	631.0	COG1482@1|root,COG1482@2|Bacteria,4NGGP@976|Bacteroidetes,47NZ6@768503|Cytophagia	976|Bacteroidetes	G	cell wall glycoprotein biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1699686_35	381764.Fnod_0699	2.351e-20	107.0	COG3862@1|root,COG3862@2|Bacteria,2GD7F@200918|Thermotogae	200918|Thermotogae	S	protein with conserved CXXC pairs	-	-	-	-	-	-	-	-	-	-	-	-	DUF1667
SX3_k127_1699686_6	889378.Spiaf_0323	1.455e-142	464.0	COG0446@1|root,COG0446@2|Bacteria,2J5ZG@203691|Spirochaetes	203691|Spirochaetes	C	pyridine nucleotide-disulfide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
SX3_k127_1699686_1	744872.Spica_2723	2.553e-176	569.0	COG0579@1|root,COG0579@2|Bacteria,2J61Q@203691|Spirochaetes	203691|Spirochaetes	C	Oxidoreductase	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,Fer2_BFD
SX3_k127_1699686_36	880073.Calab_1679	2.776e-19	91.0	COG0347@1|root,COG0347@2|Bacteria,2NRH8@2323|unclassified Bacteria	2|Bacteria	K	Belongs to the P(II) protein family	-	-	-	ko:K02806,ko:K04752	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	P-II
SX3_k127_1699686_33	717231.Flexsi_0986	7.357e-24	107.0	COG1762@1|root,COG1762@2|Bacteria,2GFU6@200930|Deferribacteres	200930|Deferribacteres	G	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
SX3_k127_1699686_11	351160.RCIX509	3.299e-119	402.0	COG0082@1|root,arCOG04133@2157|Archaea,2XT26@28890|Euryarchaeota,2N90S@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
SX3_k127_1699686_24	1499967.BAYZ01000059_gene4782	1.054e-64	248.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,HAMP,HATPase_c,HisKA,PAS,dCache_3
SX3_k127_1699686_8	1120972.AUMH01000017_gene774	1.158e-132	442.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
SX3_k127_1699686_5	1499967.BAYZ01000009_gene5236	1.674e-149	483.0	COG0412@1|root,COG0412@2|Bacteria	2|Bacteria	Q	carboxymethylenebutenolidase activity	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_7,DLH,Peptidase_S9
SX3_k127_1699686_32	593117.TGAM_0970	3.436e-31	138.0	COG0419@1|root,COG2247@1|root,COG2319@1|root,COG5306@1|root,arCOG02559@1|root,arCOG03264@1|root,arCOG00368@2157|Archaea,arCOG00388@2157|Archaea,arCOG02491@2157|Archaea,arCOG02559@2157|Archaea,arCOG03264@2157|Archaea,arCOG03512@2157|Archaea,2XYKK@28890|Euryarchaeota,24394@183968|Thermococci	183968|Thermococci	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122,PEGA
SX3_k127_1699686_37	1100721.ALKO01000018_gene1284	2.713e-16	88.0	COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,2VK9X@28216|Betaproteobacteria,4ABVQ@80864|Comamonadaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
SX3_k127_1699686_34	324925.Ppha_1959	2.922e-22	103.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
SX3_k127_1699686_30	96561.Dole_0644	1.532e-38	149.0	COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,42MFI@68525|delta/epsilon subdivisions,2WKXD@28221|Deltaproteobacteria,2MM6V@213118|Desulfobacterales	28221|Deltaproteobacteria	S	AAA domain	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
SX3_k127_1699686_39	1499967.BAYZ01000076_gene823	8.695e-08	57.0	COG2942@1|root,COG2942@2|Bacteria	2|Bacteria	G	2-epimerase	nanE	-	5.1.3.11,5.1.3.8	ko:K01787,ko:K16213	ko00520,map00520	-	R01207,R01445,R10810	RC00289,RC00290	ko00000,ko00001,ko01000	-	-	-	GlcNAc_2-epim
SX3_k127_1699686_40	604331.AUHY01000038_gene136	7.165e-06	57.0	2DGZ3@1|root,2ZXUD@2|Bacteria,1WKRC@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
SX3_k127_1699686_31	1123386.AUIW01000009_gene1812	2.115e-34	136.0	COG1848@1|root,COG1848@2|Bacteria,1WKJ4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1699686_23	717605.Theco_0110	5.81e-78	270.0	COG2207@1|root,COG3708@1|root,COG2207@2|Bacteria,COG3708@2|Bacteria,1TQDS@1239|Firmicutes,4HJ2Z@91061|Bacilli,26TAJ@186822|Paenibacillaceae	91061|Bacilli	K	AraC family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
SX3_k127_1699686_28	889378.Spiaf_0175	1.224e-47	175.0	COG1725@1|root,COG1725@2|Bacteria,2J9B8@203691|Spirochaetes	203691|Spirochaetes	K	transcriptional regulator	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
SX3_k127_1699686_13	158189.SpiBuddy_2773	2.701e-110	368.0	COG0330@1|root,COG0330@2|Bacteria,2J73X@203691|Spirochaetes	203691|Spirochaetes	O	PFAM SPFH domain Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
SX3_k127_1699686_26	1480694.DC28_12400	2.854e-58	214.0	COG1136@1|root,COG1136@2|Bacteria,2J7FN@203691|Spirochaetes	203691|Spirochaetes	V	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003,ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_1727407_1	997296.PB1_11144	2.028e-122	400.0	COG1082@1|root,COG1082@2|Bacteria,1TPJT@1239|Firmicutes,4H9KJ@91061|Bacilli,1ZCIZ@1386|Bacillus	91061|Bacilli	G	Xylose isomerase	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
SX3_k127_1727407_14	290317.Cpha266_1441	3.826e-26	109.0	COG1724@1|root,COG1724@2|Bacteria	2|Bacteria	N	mRNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
SX3_k127_1727407_16	357808.RoseRS_1787	2.13e-20	92.0	COG1598@1|root,COG1598@2|Bacteria	2|Bacteria	N	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1727407_7	1033743.CAES01000045_gene184	4.303e-70	249.0	COG2197@1|root,COG2197@2|Bacteria,1V3UP@1239|Firmicutes,4HI7B@91061|Bacilli,26S14@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
SX3_k127_1727407_6	293826.Amet_3716	3.779e-84	293.0	COG4585@1|root,COG4585@2|Bacteria,1UUZ9@1239|Firmicutes,248T2@186801|Clostridia,36W11@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3,HisKA_7TM
SX3_k127_1727407_12	1122917.KB899663_gene2805	2.32e-41	167.0	COG1511@1|root,COG1511@2|Bacteria,1V29V@1239|Firmicutes,4HFPS@91061|Bacilli	91061|Bacilli	S	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
SX3_k127_1727407_18	66692.ABC2122	1.101e-15	87.0	COG0842@1|root,COG0842@2|Bacteria,1V5GP@1239|Firmicutes,4HH0T@91061|Bacilli,1ZG1H@1386|Bacillus	91061|Bacilli	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
SX3_k127_1727407_0	1408422.JHYF01000013_gene520	4.532e-131	425.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia,36DTX@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SX3_k127_1727407_10	1304874.JAFY01000002_gene130	3.986e-52	193.0	COG3860@1|root,COG3860@2|Bacteria,3TC9Y@508458|Synergistetes	508458|Synergistetes	S	Uncharacterized protein conserved in bacteria (DUF2087)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2087
SX3_k127_1727407_5	1123377.AUIV01000012_gene721	6.358e-85	295.0	COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,1RRXR@1236|Gammaproteobacteria,1XAEU@135614|Xanthomonadales	135614|Xanthomonadales	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
SX3_k127_1727407_19	504472.Slin_3910	1.65e-06	57.0	COG4319@1|root,COG4319@2|Bacteria,4NQVC@976|Bacteroidetes,47U4E@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
SX3_k127_1727407_8	543728.Vapar_3549	1.361e-57	229.0	COG0457@1|root,COG2197@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2197@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2VPH8@28216|Betaproteobacteria,4AF3Y@80864|Comamonadaceae	28216|Betaproteobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD
SX3_k127_1727407_15	96561.Dole_2579	1.176e-25	114.0	COG0500@1|root,COG2226@2|Bacteria,1Q19G@1224|Proteobacteria,43A0G@68525|delta/epsilon subdivisions,2X4KE@28221|Deltaproteobacteria,2MNBE@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
SX3_k127_1727407_17	330214.NIDE0660	1.235e-18	91.0	COG1373@1|root,COG1373@2|Bacteria,3J14P@40117|Nitrospirae	40117|Nitrospirae	S	AAA domain	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
SX3_k127_1727407_13	927677.ALVU02000001_gene2473	7.33e-35	140.0	COG3339@1|root,COG3339@2|Bacteria,1G7DF@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
SX3_k127_1727407_3	760011.Spico_1318	1.242e-114	398.0	COG0826@1|root,COG0826@2|Bacteria,2J667@203691|Spirochaetes	203691|Spirochaetes	O	Peptidase U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
SX3_k127_1727407_11	754027.HMPREF9554_00730	9.589e-47	181.0	COG2199@1|root,COG3706@2|Bacteria,2J5S2@203691|Spirochaetes	203691|Spirochaetes	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,cNMP_binding
SX3_k127_1727407_9	744872.Spica_2521	7.998e-57	227.0	COG2199@1|root,COG3706@2|Bacteria,2J6RG@203691|Spirochaetes	203691|Spirochaetes	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,cNMP_binding
SX3_k127_1727407_4	545695.TREAZ_3287	2.035e-88	326.0	COG0618@1|root,COG0618@2|Bacteria,2J6ZI@203691|Spirochaetes	203691|Spirochaetes	S	DHH family	-	-	-	-	-	-	-	-	-	-	-	-	DHH
SX3_k127_1727407_2	1123274.KB899409_gene559	3.636e-118	392.0	COG0498@1|root,COG0498@2|Bacteria,2J84W@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SX3_k127_1731580_3	889378.Spiaf_1692	8.38e-124	414.0	COG0587@1|root,COG0587@2|Bacteria,2J5DA@203691|Spirochaetes	203691|Spirochaetes	L	DNA polymerase	-	-	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
SX3_k127_1731580_1	1480694.DC28_08450	4.348e-154	494.0	COG0686@1|root,COG0686@2|Bacteria,2J6R2@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the AlaDH PNT family	-	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
SX3_k127_1731580_4	545695.TREAZ_2381	5.816e-47	185.0	COG0457@1|root,COG0457@2|Bacteria,2J8BT@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
SX3_k127_1731580_2	573413.Spirs_0873	5.039e-134	437.0	COG0240@1|root,COG0240@2|Bacteria,2J68Z@203691|Spirochaetes	203691|Spirochaetes	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
SX3_k127_1731580_0	572546.Arcpr_0660	0.0	1251.0	COG0458@1|root,arCOG01594@2157|Archaea,2XTVE@28890|Euryarchaeota,245PG@183980|Archaeoglobi	183980|Archaeoglobi	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
SX3_k127_1745008_3	926549.KI421517_gene3390	6.696e-103	340.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SX3_k127_1745008_0	926549.KI421517_gene3391	1.841e-182	577.0	COG0673@1|root,COG0673@2|Bacteria,4NG5E@976|Bacteroidetes,47NZU@768503|Cytophagia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX3_k127_1745008_1	1499967.BAYZ01000159_gene503	9.126e-163	525.0	COG2407@1|root,COG2407@2|Bacteria	2|Bacteria	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1745008_6	1396141.BATP01000002_gene4806	9.274e-60	222.0	COG0800@1|root,COG0800@2|Bacteria,46V7J@74201|Verrucomicrobia,2IU9V@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	KDPG and KHG aldolase	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase
SX3_k127_1745008_4	1122917.KB899663_gene2684	2.237e-69	243.0	COG1349@1|root,COG1349@2|Bacteria,1TSF8@1239|Firmicutes,4HDT9@91061|Bacilli,26T41@186822|Paenibacillaceae	91061|Bacilli	K	transcriptional	-	-	-	ko:K03436	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
SX3_k127_1745008_5	1123508.JH636440_gene2608	1.796e-61	235.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,HATPase_c,HisKA,PAS_9,Response_reg
SX3_k127_1745008_2	604354.TSIB_1009	1.577e-104	355.0	COG2414@1|root,arCOG00706@2157|Archaea,2XTUP@28890|Euryarchaeota,242U3@183968|Thermococci	183968|Thermococci	C	aldehyde ferredoxin oxidoreductase	aor	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
SX3_k127_1750583_3	1343740.M271_42435	4.188e-27	111.0	COG0554@1|root,COG0554@2|Bacteria,2GM13@201174|Actinobacteria	201174|Actinobacteria	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	-	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
SX3_k127_1750583_0	697281.Mahau_0042	1.442e-157	510.0	COG1979@1|root,COG1979@2|Bacteria,1TPS3@1239|Firmicutes,248DW@186801|Clostridia,42EKX@68295|Thermoanaerobacterales	186801|Clostridia	C	alcohol dehydrogenase	-	-	-	ko:K19955	-	-	-	-	ko00000,ko01000	-	-	-	Fe-ADH
SX3_k127_1750583_2	290399.Arth_1804	7.487e-91	311.0	COG1063@1|root,COG1063@2|Bacteria,2GKC7@201174|Actinobacteria	201174|Actinobacteria	E	alcohol dehydrogenase	tdh	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
SX3_k127_1750583_1	1042326.AZNV01000029_gene3535	1.185e-109	366.0	COG1063@1|root,COG1063@2|Bacteria,1QVAK@1224|Proteobacteria,2TXH7@28211|Alphaproteobacteria,4BEBE@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Zinc-binding dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
SX3_k127_1750583_4	298655.KI912266_gene4973	0.0004335	46.0	COG1028@1|root,COG1028@2|Bacteria,2GMQE@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
SX3_k127_17771_10	1454004.AW11_03844	1.311e-101	335.0	COG1483@1|root,COG1483@2|Bacteria,1MX1G@1224|Proteobacteria,2VHB3@28216|Betaproteobacteria,1KQ8Z@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF499)	-	-	-	ko:K06922	-	-	-	-	ko00000	-	-	-	DUF499
SX3_k127_17771_19	158189.SpiBuddy_0328	5.856e-30	127.0	COG5340@1|root,COG5340@2|Bacteria,2JAKA@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator, AbiEi antitoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_17771_12	158189.SpiBuddy_0327	3.649e-75	267.0	COG2253@1|root,COG2253@2|Bacteria,2J5IH@203691|Spirochaetes	203691|Spirochaetes	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
SX3_k127_17771_22	118168.MC7420_7621	9.256e-23	100.0	2E3EN@1|root,32YDN@2|Bacteria,1G88H@1117|Cyanobacteria,1HDXU@1150|Oscillatoriales	1117|Cyanobacteria	S	Domain of unknown function (DUF4160)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4160
SX3_k127_17771_24	340177.Cag_1066	1.486e-10	65.0	2DQ4M@1|root,334QD@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
SX3_k127_17771_1	889378.Spiaf_1800	1.732e-186	595.0	COG1249@1|root,COG1249@2|Bacteria,2J7JJ@203691|Spirochaetes	203691|Spirochaetes	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
SX3_k127_17771_7	1499967.BAYZ01000075_gene2070	4.294e-125	411.0	COG0508@1|root,COG0508@2|Bacteria,2NNYD@2323|unclassified Bacteria	2|Bacteria	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	pdhC	-	1.2.4.1,2.3.1.12	ko:K00162,ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R02569,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02857,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
SX3_k127_17771_5	1499967.BAYZ01000075_gene2069	7.377e-156	510.0	COG0022@1|root,COG0022@2|Bacteria,2NNQZ@2323|unclassified Bacteria	2|Bacteria	C	Transketolase, pyrimidine binding domain	pdhB	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2753	Biotin_lipoyl,Transket_pyr,Transketolase_C
SX3_k127_17771_6	1499967.BAYZ01000075_gene2068	2.09e-139	449.0	COG1071@1|root,COG1071@2|Bacteria,2NQC2@2323|unclassified Bacteria	2|Bacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
SX3_k127_17771_14	1499967.BAYZ01000075_gene2067	2.842e-42	159.0	COG3871@1|root,COG3871@2|Bacteria	2|Bacteria	S	Pyridoxamine 5'-phosphate oxidase	ydaG	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	Putative_PNPOx,Pyrid_ox_like
SX3_k127_17771_4	1178825.ALIH01000006_gene1427	6.231e-164	535.0	COG1387@1|root,COG1387@2|Bacteria,4PFQB@976|Bacteroidetes,1I844@117743|Flavobacteriia	976|Bacteroidetes	E	Histidinol phosphatase and related hydrolases of the PHP family	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_17771_13	518766.Rmar_1269	1.74e-43	179.0	COG0344@1|root,COG0344@2|Bacteria,4NMU3@976|Bacteroidetes,1FJ88@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
SX3_k127_17771_8	1480694.DC28_08565	1.816e-114	391.0	COG1461@1|root,COG1461@2|Bacteria	2|Bacteria	S	glycerone kinase activity	yfhG	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak1_2,Dak2,DegV
SX3_k127_17771_9	545694.TREPR_0450	5.99e-109	362.0	COG0545@1|root,COG0652@1|root,COG0545@2|Bacteria,COG0652@2|Bacteria,2J58N@203691|Spirochaetes	203691|Spirochaetes	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	5.2.1.8	ko:K01802,ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	FKBP_C,Pro_isomerase
SX3_k127_17771_11	635013.TherJR_0148	4.898e-79	278.0	COG0348@1|root,COG0348@2|Bacteria,1TPHF@1239|Firmicutes,247KH@186801|Clostridia,2604C@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
SX3_k127_17771_3	383372.Rcas_2159	7.072e-170	547.0	COG1350@1|root,COG1350@2|Bacteria,2G5YY@200795|Chloroflexi,376QX@32061|Chloroflexia	32061|Chloroflexia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SX3_k127_17771_18	713587.THITH_13690	1.799e-31	134.0	COG0363@1|root,COG0363@2|Bacteria,1R5K6@1224|Proteobacteria,1SYT9@1236|Gammaproteobacteria,1X25R@135613|Chromatiales	135613|Chromatiales	G	PFAM glucosamine galactosamine-6-phosphate isomerase	-	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
SX3_k127_17771_21	889378.Spiaf_0197	4.838e-23	114.0	COG3429@1|root,COG3429@2|Bacteria,2JB35@203691|Spirochaetes	203691|Spirochaetes	G	Glucose-6-phosphate dehydrogenase subunit	-	-	-	-	-	-	-	-	-	-	-	-	OpcA_G6PD_assem
SX3_k127_17771_2	889378.Spiaf_0198	2.16e-172	560.0	COG0364@1|root,COG0364@2|Bacteria,2J6N0@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
SX3_k127_17771_17	665571.STHERM_c19990	7.858e-33	139.0	COG0340@1|root,COG0340@2|Bacteria,2J617@203691|Spirochaetes	203691|Spirochaetes	H	biotin acetyl-CoA-carboxylase ligase	-	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB
SX3_k127_17771_16	573413.Spirs_3803	2.776e-33	141.0	COG0560@1|root,COG0560@2|Bacteria,2JB1Y@203691|Spirochaetes	203691|Spirochaetes	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
SX3_k127_17771_0	744872.Spica_0427	3.196e-275	854.0	COG0459@1|root,COG0459@2|Bacteria,2J5CK@203691|Spirochaetes	203691|Spirochaetes	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
SX3_k127_17771_23	573413.Spirs_3239	1.567e-15	79.0	28WXW@1|root,2ZIX0@2|Bacteria,2J96G@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_17771_20	1047013.AQSP01000138_gene1034	1.118e-24	112.0	COG0789@1|root,COG0789@2|Bacteria	2|Bacteria	K	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding	-	-	4.6.1.1	ko:K01768,ko:K03713,ko:K11923,ko:K13638	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko03000	-	-	-	MerR_1
SX3_k127_17771_15	573413.Spirs_3238	6.687e-38	145.0	COG1862@1|root,COG1862@2|Bacteria,2J8D6@203691|Spirochaetes	203691|Spirochaetes	U	Preprotein translocase, YajC subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
SX3_k127_17771_26	744872.Spica_1832	1.989e-06	50.0	COG0342@1|root,COG0342@2|Bacteria,2J5UV@203691|Spirochaetes	203691|Spirochaetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
SX3_k127_1792185_1	158190.SpiGrapes_1081	1.604e-41	169.0	COG1033@1|root,COG1033@2|Bacteria,2J636@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG1033 exporter of the RND superfamily protein	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
SX3_k127_1792185_3	1220534.B655_1171	3.159e-27	128.0	COG0451@1|root,arCOG01369@2157|Archaea,2XUDM@28890|Euryarchaeota	28890|Euryarchaeota	M	NAD-dependent epimerase dehydratase	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
SX3_k127_1792185_8	1144275.COCOR_00909	0.0001629	52.0	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,42QIX@68525|delta/epsilon subdivisions,2WJHE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
SX3_k127_1792185_4	530564.Psta_4642	1.24e-18	98.0	COG1215@1|root,COG1215@2|Bacteria,2IZ8G@203682|Planctomycetes	203682|Planctomycetes	M	glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_21
SX3_k127_1792185_0	290512.Paes_1952	1.939e-43	179.0	COG0451@1|root,COG0451@2|Bacteria,1FDVP@1090|Chlorobi	1090|Chlorobi	M	PFAM NAD-dependent epimerase dehydratase	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
SX3_k127_1792185_6	649638.Trad_1558	1.521e-10	71.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
SX3_k127_1792185_2	485918.Cpin_2399	5.213e-32	138.0	COG0451@1|root,COG0451@2|Bacteria,4NEJJ@976|Bacteroidetes,1IP9J@117747|Sphingobacteriia	976|Bacteroidetes	M	NAD dependent epimerase dehydratase family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
SX3_k127_1792185_5	1195236.CTER_4907	9.663e-15	89.0	COG3534@1|root,COG4733@1|root,COG5184@1|root,COG3534@2|Bacteria,COG4733@2|Bacteria,COG5184@2|Bacteria,1TPG2@1239|Firmicutes,24AVP@186801|Clostridia,3WRD0@541000|Ruminococcaceae	186801|Clostridia	DGZ	Alpha-L-arabinofuranosidase C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-L-AF_C,CBM_4_9,Cadherin-like,DUF1080,Laminin_G_3
SX3_k127_1792185_7	1214101.BN159_1654	7.319e-07	61.0	COG5621@1|root,COG5621@2|Bacteria,2GNHM@201174|Actinobacteria	201174|Actinobacteria	S	secreted hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CrtC
SX3_k127_1804877_1	937777.Deipe_2230	5.64e-09	65.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_23,HTH_33
SX3_k127_1804877_0	889378.Spiaf_1081	5.81e-86	303.0	COG1624@1|root,COG1762@1|root,COG1624@2|Bacteria,COG1762@2|Bacteria,2J84N@203691|Spirochaetes	203691|Spirochaetes	G	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
SX3_k127_1811409_2	306281.AJLK01000021_gene2989	7.239e-16	86.0	COG1520@1|root,COG4932@1|root,COG1520@2|Bacteria,COG4932@2|Bacteria,1G7EX@1117|Cyanobacteria,1JMWU@1189|Stigonemataceae	1117|Cyanobacteria	M	Bacterial pre-peptidase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	PPC
SX3_k127_1811409_0	889378.Spiaf_0513	9.234e-145	475.0	COG1288@1|root,COG1288@2|Bacteria,2J88I@203691|Spirochaetes	203691|Spirochaetes	S	C4-dicarboxylate anaerobic carrier	-	-	-	-	-	-	-	-	-	-	-	-	DcuC
SX3_k127_1811409_1	889378.Spiaf_0514	5.386e-96	328.0	COG0624@1|root,COG0624@2|Bacteria,2J743@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Peptidase family M20 M25 M40	-	-	-	ko:K13049	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
SX3_k127_1812716_15	926569.ANT_07420	3.382e-39	147.0	COG1079@1|root,COG1079@2|Bacteria,2G7KY@200795|Chloroflexi	200795|Chloroflexi	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
SX3_k127_1812716_0	926550.CLDAP_15520	1.863e-204	649.0	COG1397@1|root,COG1397@2|Bacteria	2|Bacteria	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
SX3_k127_1812716_16	443143.GM18_4225	1.053e-29	126.0	COG1802@1|root,COG1802@2|Bacteria,1MWG2@1224|Proteobacteria,42P4Y@68525|delta/epsilon subdivisions,2WM8E@28221|Deltaproteobacteria,43S47@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	regulatory protein GntR HTH	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
SX3_k127_1812716_3	1033734.CAET01000006_gene3897	1.11e-131	434.0	COG1653@1|root,COG1653@2|Bacteria,1TQFZ@1239|Firmicutes,4HA0U@91061|Bacilli,1ZCPV@1386|Bacillus	91061|Bacilli	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
SX3_k127_1812716_9	1121346.KB899810_gene1523	6.759e-94	317.0	COG1175@1|root,COG1175@2|Bacteria,1V109@1239|Firmicutes,4HC5A@91061|Bacilli,26UKR@186822|Paenibacillaceae	91061|Bacilli	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX3_k127_1812716_8	1122915.AUGY01000044_gene7532	3.671e-98	328.0	COG0395@1|root,COG0395@2|Bacteria,1TRXW@1239|Firmicutes,4HDNH@91061|Bacilli,26VJR@186822|Paenibacillaceae	91061|Bacilli	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX3_k127_1812716_1	1499967.BAYZ01000141_gene6143	4.184e-136	447.0	COG0001@1|root,COG0001@2|Bacteria,2NNV5@2323|unclassified Bacteria	2|Bacteria	H	PFAM aminotransferase class-III	-	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006083,GO:0006091,GO:0006113,GO:0006520,GO:0006553,GO:0006554,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009987,GO:0015980,GO:0016054,GO:0016740,GO:0016769,GO:0016999,GO:0017144,GO:0019475,GO:0019477,GO:0019665,GO:0019666,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0036094,GO:0042737,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0046440,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.6.1.111,5.4.3.8	ko:K01845,ko:K21585	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272,R11607	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SX3_k127_1812716_12	572547.Amico_1664	5.373e-77	277.0	COG3875@1|root,COG3875@2|Bacteria,3TC3R@508458|Synergistetes	508458|Synergistetes	S	Domain of unknown function (DUF2088)	-	-	5.1.2.1	ko:K22373	ko00620,map00620	-	R01450	RC00519	ko00000,ko00001,ko01000	-	-	-	DUF2088
SX3_k127_1812716_5	1499967.BAYZ01000141_gene6142	2.326e-120	398.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
SX3_k127_1812716_10	1499967.BAYZ01000141_gene6144	4.854e-86	297.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_1812716_14	525904.Tter_2870	1.767e-61	225.0	COG0704@1|root,COG0704@2|Bacteria,2NPWX@2323|unclassified Bacteria	2|Bacteria	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
SX3_k127_1812716_7	335543.Sfum_0701	5.642e-107	355.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,42MWA@68525|delta/epsilon subdivisions,2WJEX@28221|Deltaproteobacteria,2MR99@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
SX3_k127_1812716_11	1210884.HG799462_gene7887	4.436e-85	303.0	COG1117@1|root,COG1117@2|Bacteria,2IWRV@203682|Planctomycetes	203682|Planctomycetes	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
SX3_k127_1812716_4	335543.Sfum_0703	3.154e-124	418.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,42MWK@68525|delta/epsilon subdivisions,2WJKH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	TIGRFAM phosphate ABC transporter, inner membrane subunit PstA	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
SX3_k127_1812716_2	335543.Sfum_0704	1.274e-134	435.0	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,42N2N@68525|delta/epsilon subdivisions,2WJJ1@28221|Deltaproteobacteria,2MQY5@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
SX3_k127_1812716_6	335543.Sfum_0705	6.586e-112	370.0	COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,42P0G@68525|delta/epsilon subdivisions,2WK7Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	TIGRFAM phosphate binding protein	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
SX3_k127_1812716_17	1499967.BAYZ01000131_gene366	2.591e-28	120.0	COG3807@1|root,COG3807@2|Bacteria,2NRZY@2323|unclassified Bacteria	2|Bacteria	S	Src homology 3 domains	yrvJ	-	3.2.1.96,3.4.17.14,3.5.1.28	ko:K01227,ko:K01447,ko:K01448,ko:K06385,ko:K07260,ko:K11060,ko:K11062,ko:K21472	ko00511,ko00550,ko01100,ko01502,ko01503,ko02020,map00511,map00550,map01100,map01502,map01503,map02020	M00651,M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko02042,ko03036	-	-	-	Amidase_3,Glucosaminidase,NLPC_P60,SH3_3,SH3_4
SX3_k127_1812716_13	1121438.JNJA01000016_gene1503	2.957e-69	257.0	COG4783@1|root,COG4783@2|Bacteria,1R84W@1224|Proteobacteria,42QAH@68525|delta/epsilon subdivisions,2WKH8@28221|Deltaproteobacteria,2MA6S@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
SX3_k127_1812716_18	1499967.BAYZ01000131_gene368	8.557e-16	78.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,2NP16@2323|unclassified Bacteria	2|Bacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
SX3_k127_1840828_5	744872.Spica_1896	1.587e-97	324.0	COG1175@1|root,COG1175@2|Bacteria,2J7QQ@203691|Spirochaetes	203691|Spirochaetes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K05814	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	BPD_transp_1
SX3_k127_1840828_0	744872.Spica_1895	2.464e-219	687.0	COG1653@1|root,COG1653@2|Bacteria,2J7XP@203691|Spirochaetes	203691|Spirochaetes	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K05813	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	SBP_bac_8
SX3_k127_1840828_9	555079.Toce_0271	6.363e-48	188.0	COG0477@1|root,COG2814@2|Bacteria,1VD2I@1239|Firmicutes,24PA4@186801|Clostridia	186801|Clostridia	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX3_k127_1840828_1	545695.TREAZ_3602	5.566e-170	548.0	COG0591@1|root,COG0591@2|Bacteria,2J6EP@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
SX3_k127_1840828_10	1114970.PSF113_3014	8.4e-44	175.0	COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RR5W@1236|Gammaproteobacteria,1YQ0P@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	AAA_16,GAF,HATPase_c,HisKA,MASE1,PAS_3,PAS_4,PAS_9,Pkinase
SX3_k127_1840828_4	1366050.N234_01355	7.282e-100	346.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,1K094@119060|Burkholderiaceae	28216|Betaproteobacteria	T	response regulator	dctD	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141	-	ko:K10126,ko:K10941	ko02020,ko02025,ko05111,map02020,map02025,map05111	M00504	-	-	ko00000,ko00001,ko00002,ko02022,ko03000	-	-	-	HTH_8,Response_reg,Sigma54_activat
SX3_k127_1840828_13	1385935.N836_04840	3.014e-14	86.0	COG1835@1|root,COG1835@2|Bacteria,1GBA1@1117|Cyanobacteria	1117|Cyanobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
SX3_k127_1840828_15	545695.TREAZ_0642	6.467e-10	66.0	2FC9X@1|root,2ZJPR@2|Bacteria,2J8DF@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1840828_3	545694.TREPR_3180	1.473e-101	350.0	COG3233@1|root,COG3233@2|Bacteria,2J7B8@203691|Spirochaetes	203691|Spirochaetes	S	deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1840828_11	545694.TREPR_1629	1.9e-37	157.0	COG0624@1|root,COG0624@2|Bacteria,2J96T@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
SX3_k127_1840828_2	744872.Spica_0874	8.156e-123	421.0	COG1215@1|root,COG1215@2|Bacteria,2J64X@203691|Spirochaetes	203691|Spirochaetes	M	Glycosyl transferase family 2	-	-	2.4.1.266	ko:K13693	-	-	-	-	ko00000,ko01000,ko01003	-	GT81	-	Glycos_transf_2
SX3_k127_1840828_8	573413.Spirs_0453	5.135e-64	238.0	COG1387@1|root,COG1387@2|Bacteria,2J6VZ@203691|Spirochaetes	203691|Spirochaetes	E	COGs COG1387 Histidinol phosphatase and related hydrolase of the PHP family	-	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP
SX3_k127_1840828_6	880073.Calab_2557	8.874e-75	268.0	COG0477@1|root,COG2814@2|Bacteria,2NS3M@2323|unclassified Bacteria	2|Bacteria	EGP	Transmembrane secretion effector	bacE	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
SX3_k127_1840828_7	502025.Hoch_1468	4.97e-74	260.0	COG0697@1|root,COG0697@2|Bacteria,1MZQM@1224|Proteobacteria,42VPN@68525|delta/epsilon subdivisions,2WRK6@28221|Deltaproteobacteria,2Z1WG@29|Myxococcales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SX3_k127_1840828_14	525903.Taci_0690	1.465e-10	68.0	COG4109@1|root,COG4109@2|Bacteria,3TBCK@508458|Synergistetes	508458|Synergistetes	K	PFAM DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
SX3_k127_1840828_12	457415.HMPREF1006_00788	4.629e-36	148.0	COG2172@1|root,COG2172@2|Bacteria,3TB7G@508458|Synergistetes	508458|Synergistetes	T	anti-sigma regulatory factor	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2
SX3_k127_1842103_31	1307761.L21SP2_0672	7.189e-44	169.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1,Y2_Tnp,Zn_Tnp_IS91
SX3_k127_1842103_6	1254432.SCE1572_33210	4.221e-160	534.0	COG0417@1|root,COG0417@2|Bacteria,1MVY9@1224|Proteobacteria,42Q4K@68525|delta/epsilon subdivisions,2WKQ1@28221|Deltaproteobacteria,2Z1M7@29|Myxococcales	28221|Deltaproteobacteria	L	DNA polymerase type-B family	polB	-	2.7.7.7	ko:K02336	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol_B,DNA_pol_B_exo1,RNase_H_2
SX3_k127_1842103_20	697281.Mahau_0032	4.904e-72	260.0	COG0407@1|root,COG0407@2|Bacteria,1V5KX@1239|Firmicutes,24IAR@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_1842103_21	1121946.AUAX01000022_gene3840	1.044e-68	242.0	2DBF0@1|root,2Z8VT@2|Bacteria,2I88D@201174|Actinobacteria,4DIBF@85008|Micromonosporales	201174|Actinobacteria	S	3-oxo-5-alpha-steroid 4-dehydrogenase	-	-	1.3.1.22	ko:K12343	ko00140,map00140	-	R02208,R02497,R08954,R10242	RC00145	ko00000,ko00001,ko01000	-	-	-	Steroid_dh
SX3_k127_1842103_17	1499967.BAYZ01000073_gene2029	3.697e-76	261.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
SX3_k127_1842103_13	1449050.JNLE01000003_gene3794	1.153e-92	320.0	COG0282@1|root,COG0282@2|Bacteria,1TQ22@1239|Firmicutes,248ZM@186801|Clostridia,36EE0@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
SX3_k127_1842103_30	573413.Spirs_0214	1.073e-48	184.0	COG1349@1|root,COG1349@2|Bacteria,2J9ST@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, deoR family	-	-	-	ko:K11534	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
SX3_k127_1842103_16	536232.CLM_1429	5.71e-80	275.0	COG0235@1|root,COG0235@2|Bacteria,1TS5G@1239|Firmicutes,248NY@186801|Clostridia,36H4D@31979|Clostridiaceae	186801|Clostridia	G	Class II aldolase	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
SX3_k127_1842103_4	1121904.ARBP01000005_gene4588	2.927e-180	592.0	COG0726@1|root,COG0726@2|Bacteria,4NNN4@976|Bacteroidetes	976|Bacteroidetes	G	Glycosyl hydrolase family 9	-	-	-	-	-	-	-	-	-	-	-	-	CelD_N,Glyco_hydro_9
SX3_k127_1842103_15	697281.Mahau_2253	5.691e-84	316.0	COG0407@1|root,COG0407@2|Bacteria,1V4YU@1239|Firmicutes,24FCZ@186801|Clostridia,42HY1@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
SX3_k127_1842103_0	573413.Spirs_0312	1.13e-264	830.0	COG0173@1|root,COG0173@2|Bacteria,2J5KG@203691|Spirochaetes	203691|Spirochaetes	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
SX3_k127_1842103_8	335541.Swol_2172	5.634e-152	493.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
SX3_k127_1842103_7	485913.Krac_11859	2.29e-153	500.0	COG0520@1|root,COG0520@2|Bacteria,2G5W7@200795|Chloroflexi	200795|Chloroflexi	E	TIGRFAM cysteine desulfurase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
SX3_k127_1842103_33	1123504.JQKD01000012_gene1238	1.265e-31	130.0	COG1848@1|root,COG1848@2|Bacteria,1RK9K@1224|Proteobacteria	1224|Proteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
SX3_k127_1842103_39	985255.APHJ01000017_gene2173	7.852e-11	70.0	2CIUH@1|root,32S8I@2|Bacteria,4NWAC@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1842103_9	383372.Rcas_3626	6.18e-141	458.0	COG0477@1|root,COG0477@2|Bacteria,2GA6R@200795|Chloroflexi,3782R@32061|Chloroflexia	32061|Chloroflexia	EGP	major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
SX3_k127_1842103_26	368407.Memar_2454	1.102e-58	214.0	COG4802@1|root,arCOG01100@2157|Archaea,2XXWK@28890|Euryarchaeota	28890|Euryarchaeota	C	Ferredoxin thioredoxin reductase catalytic beta chain	-	-	-	-	-	-	-	-	-	-	-	-	FeThRed_B
SX3_k127_1842103_36	868131.MSWAN_0171	7.254e-26	110.0	COG0695@1|root,arCOG02606@2157|Archaea,2Y0MA@28890|Euryarchaeota	28890|Euryarchaeota	O	PFAM glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
SX3_k127_1842103_34	545695.TREAZ_1752	2.161e-30	124.0	COG0071@1|root,COG0071@2|Bacteria,2J88K@203691|Spirochaetes	203691|Spirochaetes	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K06335,ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
SX3_k127_1842103_23	1111479.AXAR01000001_gene311	2.895e-65	240.0	COG5482@1|root,COG5482@2|Bacteria,1V3FI@1239|Firmicutes,4HI6C@91061|Bacilli	91061|Bacilli	S	Putative PD-(D/E)XK phosphodiesterase (DUF2161)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2161
SX3_k127_1842103_32	331869.BAL199_28280	1.679e-39	157.0	COG0388@1|root,COG0388@2|Bacteria,1RA15@1224|Proteobacteria,2U1MJ@28211|Alphaproteobacteria,4BR7D@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
SX3_k127_1842103_29	138119.DSY2876	1.268e-53	214.0	COG4869@1|root,COG4869@2|Bacteria,1V242@1239|Firmicutes,24816@186801|Clostridia,261ZD@186807|Peptococcaceae	186801|Clostridia	Q	Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate	-	-	2.3.1.8	ko:K15024	ko00430,ko00620,ko00640,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00720,map01100,map01120,map01200	M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	PTAC
SX3_k127_1842103_22	1047013.AQSP01000140_gene2513	1.085e-67	243.0	COG1322@1|root,COG1322@2|Bacteria,2NPXU@2323|unclassified Bacteria	2|Bacteria	S	RmuC family	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
SX3_k127_1842103_42	391037.Sare_0385	0.0008114	50.0	COG0454@1|root,COG0456@2|Bacteria,2I41B@201174|Actinobacteria,4DCVF@85008|Micromonosporales	201174|Actinobacteria	K	Gcn5-related n-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SX3_k127_1842103_10	545695.TREAZ_1653	7.857e-100	338.0	COG0407@1|root,COG0407@2|Bacteria,2JAFK@203691|Spirochaetes	203691|Spirochaetes	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
SX3_k127_1842103_2	1244869.H261_15452	2.542e-247	795.0	COG0664@1|root,COG1235@1|root,COG2703@1|root,COG0664@2|Bacteria,COG1235@2|Bacteria,COG2703@2|Bacteria,1R90N@1224|Proteobacteria,2TTTI@28211|Alphaproteobacteria,2JVDD@204441|Rhodospirillales	204441|Rhodospirillales	PT	COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin,Lactamase_B_2,cNMP_binding
SX3_k127_1842103_18	545694.TREPR_3192	1.793e-74	268.0	COG0755@1|root,COG0755@2|Bacteria,2JADE@203691|Spirochaetes	203691|Spirochaetes	O	Cytochrome C assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
SX3_k127_1842103_37	545694.TREPR_3193	4.74e-22	108.0	COG1333@1|root,COG1333@2|Bacteria,2JAVY@203691|Spirochaetes	203691|Spirochaetes	O	ResB-like family	-	-	-	ko:K07399	-	-	-	-	ko00000	-	-	-	ResB
SX3_k127_1842103_24	794903.OPIT5_22635	4.196e-62	233.0	COG1028@1|root,COG1028@2|Bacteria	794903.OPIT5_22635|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1842103_25	1499967.BAYZ01000177_gene5703	1.808e-59	216.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX3_k127_1842103_19	1150399.AQYK01000002_gene3196	2.595e-72	255.0	COG1175@1|root,COG1175@2|Bacteria,2GM6N@201174|Actinobacteria,4FTG5@85023|Microbacteriaceae	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025,ko:K17330	ko02010,map02010	M00207,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.33	-	-	BPD_transp_1
SX3_k127_1842103_35	33035.JPJF01000068_gene4481	9.254e-30	136.0	COG1653@1|root,COG1653@2|Bacteria,1TRIH@1239|Firmicutes,248X0@186801|Clostridia,3Y14V@572511|Blautia	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
SX3_k127_1842103_40	1047013.AQSP01000130_gene1868	2.231e-09	69.0	COG0407@1|root,COG0407@2|Bacteria,2NQRU@2323|unclassified Bacteria	2|Bacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_1842103_38	180332.JTGN01000003_gene1959	3.322e-16	91.0	COG0407@1|root,COG0407@2|Bacteria,1VJHK@1239|Firmicutes,24TV3@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_1842103_14	1499967.BAYZ01000118_gene3242	2.834e-85	297.0	COG2017@1|root,COG2017@2|Bacteria,2NQQX@2323|unclassified Bacteria	2|Bacteria	G	Domain of unknown function (DUF4432)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4432
SX3_k127_1842103_28	537013.CLOSTMETH_01121	8.369e-57	212.0	COG1063@1|root,COG1063@2|Bacteria,1V57T@1239|Firmicutes,24IGM@186801|Clostridia,3WNFU@541000|Ruminococcaceae	186801|Clostridia	C	Psort location Cytoplasmic, score 9.98	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
SX3_k127_1842103_12	253839.SSNG_00449	2.312e-94	325.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
SX3_k127_1842103_27	1382358.JHVN01000003_gene2767	2.106e-58	218.0	COG1940@1|root,COG1940@2|Bacteria,1TQCE@1239|Firmicutes,4HDE3@91061|Bacilli,21VCB@150247|Anoxybacillus	91061|Bacilli	GK	ROK family	xylR	-	-	-	-	-	-	-	-	-	-	-	HTH_24,MarR_2,ROK
SX3_k127_1842103_5	1499967.BAYZ01000017_gene6251	7.609e-166	529.0	COG0363@1|root,COG0363@2|Bacteria	2|Bacteria	G	glucosamine-6-phosphate deaminase activity	nagB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	3.1.1.31,3.5.99.6	ko:K01057,ko:K02564	ko00030,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00520,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R00765,R02035	RC00163,RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
SX3_k127_1842103_41	671143.DAMO_2676	0.0003034	46.0	COG1848@1|root,COG1848@2|Bacteria,2NRZ1@2323|unclassified Bacteria	2|Bacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
SX3_k127_1842103_1	665571.STHERM_c01540	7.092e-259	855.0	COG3420@1|root,COG4733@1|root,COG3420@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	5.1.3.37	ko:K01795,ko:K20276	ko00051,ko02024,map00051,map02024	-	R08693	RC00509	ko00000,ko00001,ko01000	-	-	-	Beta_helix,Big_2,F5_F8_type_C,SLH,TIR_2
SX3_k127_1842103_3	889378.Spiaf_2453	2.684e-190	659.0	COG4733@1|root,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,DUF1983,DUF285,PA14,VCBS,fn3
SX3_k127_1842103_11	573413.Spirs_3933	1.608e-95	347.0	COG2911@1|root,COG2911@2|Bacteria,2J6UE@203691|Spirochaetes	203691|Spirochaetes	U	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	FlgD_ig
SX3_k127_1848263_3	768670.Calni_0514	2.872e-19	87.0	COG0019@1|root,COG0019@2|Bacteria,2GF5Z@200930|Deferribacteres	200930|Deferribacteres	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
SX3_k127_1848263_2	1121381.JNIV01000236_gene1134	4.592e-20	94.0	COG2026@1|root,COG2026@2|Bacteria	2|Bacteria	DJ	nuclease activity	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
SX3_k127_1848263_6	744872.Spica_2160	6.49e-11	67.0	COG2161@1|root,COG2161@2|Bacteria,2J8GQ@203691|Spirochaetes	203691|Spirochaetes	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
SX3_k127_1848263_7	744872.Spica_0910	8.188e-09	64.0	COG0399@1|root,COG0399@2|Bacteria,2JA54@203691|Spirochaetes	203691|Spirochaetes	M	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
SX3_k127_1848263_8	1121335.Clst_0287	3.632e-05	53.0	COG4908@1|root,COG4908@2|Bacteria,1TQXH@1239|Firmicutes,24B2C@186801|Clostridia,3WIA6@541000|Ruminococcaceae	186801|Clostridia	S	Psort location	-	-	-	-	-	-	-	-	-	-	-	-	AATase
SX3_k127_1848263_0	1499967.BAYZ01000095_gene4069	9.207e-94	320.0	COG1609@1|root,COG1879@1|root,COG1609@2|Bacteria,COG1879@2|Bacteria	2|Bacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K02529,ko:K05499,ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000,ko03000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	HTH_IclR,LacI,Peripla_BP_3,Peripla_BP_4
SX3_k127_1848263_1	1449065.JMLL01000010_gene551	4.188e-60	231.0	COG0457@1|root,COG3629@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,43HD6@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	DNA-binding transcriptional activator of the SARP family	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Guanylate_cyc
SX3_k127_1848263_5	316274.Haur_1430	9.522e-12	69.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,2G699@200795|Chloroflexi,3764S@32061|Chloroflexia	200795|Chloroflexi	T	PFAM adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc
SX3_k127_1848263_4	702437.HMPREF9432_00462	3.031e-17	85.0	COG0019@1|root,COG0019@2|Bacteria,1TPE9@1239|Firmicutes,4H2IF@909932|Negativicutes	909932|Negativicutes	E	diaminopimelate decarboxylase	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
SX3_k127_1860789_7	1227352.C173_28486	2.455e-41	156.0	COG0395@1|root,COG0395@2|Bacteria,1TPRG@1239|Firmicutes,4HDW3@91061|Bacilli,26S5J@186822|Paenibacillaceae	91061|Bacilli	G	ABC transporter permease	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
SX3_k127_1860789_2	1121377.KB906400_gene1321	1.33e-158	511.0	COG2723@1|root,COG2723@2|Bacteria,1WIBW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	PFAM Glycosyl hydrolase family 1	-	-	3.2.1.21,3.2.1.86	ko:K01223,ko:K05350	ko00010,ko00460,ko00500,ko00940,ko01100,ko01110,map00010,map00460,map00500,map00940,map01100,map01110	-	R00026,R00839,R02558,R02887,R02985,R03527,R04949,R04998,R05133,R05134,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GT1	-	Glyco_hydro_1
SX3_k127_1860789_4	1151117.AJLF01000001_gene1302	5.841e-58	215.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTX2@28890|Euryarchaeota,242XP@183968|Thermococci	183968|Thermococci	O	AIR synthase related protein, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AIRS,AIRS_C
SX3_k127_1860789_6	744872.Spica_1336	1.653e-45	174.0	2AMQG@1|root,31CKP@2|Bacteria,2J7X3@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1860789_3	545694.TREPR_1182	1.151e-103	355.0	COG0514@1|root,COG0514@2|Bacteria,2J5BY@203691|Spirochaetes	203691|Spirochaetes	L	ATP-dependent DNA helicase RecQ	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecQ_Zn_bind
SX3_k127_1860789_8	479434.Sthe_3417	1.135e-07	56.0	COG2161@1|root,COG2161@2|Bacteria	2|Bacteria	D	toxin-antitoxin pair type II binding	-	-	-	ko:K19159	-	-	-	-	ko00000,ko02048	-	-	-	PhdYeFM_antitox
SX3_k127_1860789_5	555079.Toce_0241	1.576e-48	184.0	COG1905@1|root,COG1905@2|Bacteria,1V737@1239|Firmicutes,24I29@186801|Clostridia,42ICW@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit	nuoE	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
SX3_k127_1860789_0	351627.Csac_0620	8.321e-241	770.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,42I0X@68295|Thermoanaerobacterales	186801|Clostridia	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	nuoF2	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,Fer4_20,NADH_4Fe-4S,Pyr_redox_2,SLBB
SX3_k127_1860789_1	555079.Toce_0243	3.49e-214	694.0	COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,42EUY@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.17.1.10,1.17.1.9,1.97.1.9	ko:K00123,ko:K12527,ko:K15022	ko00450,ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00450,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519,R07229	RC02420,RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_20,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Pyr_redox_2,Pyr_redox_3
SX3_k127_1876062_12	1329516.JPST01000014_gene640	0.0005959	50.0	COG0311@1|root,COG0311@2|Bacteria,1V3I6@1239|Firmicutes,4HFSZ@91061|Bacilli,27BZC@186824|Thermoactinomycetaceae	91061|Bacilli	H	SNO glutamine amidotransferase family	pdxT	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
SX3_k127_1876062_10	986075.CathTA2_1252	1.095e-17	90.0	COG0526@1|root,COG0526@2|Bacteria,1VAPY@1239|Firmicutes,4HIQ3@91061|Bacilli	91061|Bacilli	CO	Catalyzes the reduction of the disulfide bonds in the heme binding site of apocytochrome c	resA	GO:0008150,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
SX3_k127_1876062_7	880073.Calab_3788	8.076e-77	268.0	COG0451@1|root,COG0451@2|Bacteria,2NPC7@2323|unclassified Bacteria	2|Bacteria	GM	NAD(P)H-binding	JD73_00815	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
SX3_k127_1876062_11	1120971.AUCA01000044_gene1205	7.782e-11	76.0	2ACIQ@1|root,3124W@2|Bacteria,1V104@1239|Firmicutes,4HFYB@91061|Bacilli,277Z3@186823|Alicyclobacillaceae	91061|Bacilli	S	Helicase conserved C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C_3
SX3_k127_1876062_0	545695.TREAZ_2835	3.202e-178	578.0	COG1061@1|root,COG1061@2|Bacteria,2J6EB@203691|Spirochaetes	203691|Spirochaetes	L	DNA or RNA helicase of superfamily II	-	-	3.6.4.12	ko:K10843	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	ERCC3_RAD25_C,Helicase_C_3,ResIII
SX3_k127_1876062_3	926550.CLDAP_16080	1.713e-121	404.0	COG1653@1|root,COG1653@2|Bacteria,2G958@200795|Chloroflexi	200795|Chloroflexi	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
SX3_k127_1876062_4	158189.SpiBuddy_0828	2.099e-114	389.0	COG0395@1|root,COG0395@2|Bacteria,2J9WE@203691|Spirochaetes	203691|Spirochaetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX3_k127_1876062_2	760011.Spico_0868	3.298e-134	433.0	COG1175@1|root,COG1175@2|Bacteria,2J7PS@203691|Spirochaetes	203691|Spirochaetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX3_k127_1876062_1	158189.SpiBuddy_0830	3.535e-157	520.0	COG1653@1|root,COG1653@2|Bacteria,2JA1G@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Bacterial extracellular solute-binding, family 1	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
SX3_k127_1876062_8	1122917.KB899661_gene1005	9.423e-70	258.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V1IV@1239|Firmicutes,4HHN2@91061|Bacilli,26UMC@186822|Paenibacillaceae	91061|Bacilli	T	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,Response_reg
SX3_k127_1876062_5	1122915.AUGY01000069_gene2954	1.009e-110	382.0	COG2972@1|root,COG2972@2|Bacteria,1V051@1239|Firmicutes,4HHCW@91061|Bacilli,26TRX@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase,dCache_1
SX3_k127_1876062_6	1123274.KB899409_gene506	7.806e-95	322.0	COG0044@1|root,COG0044@2|Bacteria,2J6KK@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
SX3_k127_1876062_9	34506.g2343	4.272e-31	136.0	COG0448@1|root,COG0458@1|root,KOG0370@2759|Eukaryota,KOG1504@2759|Eukaryota,38CAC@33154|Opisthokonta,3B9FF@33208|Metazoa,3CS9A@33213|Bilateria,40G12@6231|Nematoda,1KYNR@119089|Chromadorea,40UXW@6236|Rhabditida	33208|Metazoa	F	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	CPS1	GO:0000050,GO:0000052,GO:0000096,GO:0000166,GO:0001101,GO:0001505,GO:0001889,GO:0002237,GO:0003008,GO:0003013,GO:0003018,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0004175,GO:0005488,GO:0005509,GO:0005524,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0006082,GO:0006508,GO:0006520,GO:0006525,GO:0006526,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007275,GO:0007494,GO:0008015,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008289,GO:0008652,GO:0009056,GO:0009058,GO:0009064,GO:0009084,GO:0009295,GO:0009410,GO:0009605,GO:0009607,GO:0009617,GO:0009636,GO:0009719,GO:0009725,GO:0009888,GO:0009987,GO:0009991,GO:0010033,GO:0010035,GO:0010038,GO:0010043,GO:0010243,GO:0014070,GO:0014074,GO:0014075,GO:0016020,GO:0016042,GO:0016053,GO:0016595,GO:0016597,GO:0016787,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0017144,GO:0019240,GO:0019433,GO:0019538,GO:0019627,GO:0019637,GO:0019752,GO:0019866,GO:0030154,GO:0030554,GO:0030855,GO:0031090,GO:0031406,GO:0031667,GO:0031960,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032094,GO:0032496,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032870,GO:0032991,GO:0033762,GO:0033993,GO:0034201,GO:0034641,GO:0035150,GO:0035295,GO:0035296,GO:0035639,GO:0036094,GO:0042133,GO:0042221,GO:0042311,GO:0042493,GO:0042592,GO:0042594,GO:0042645,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043200,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043434,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044283,GO:0044344,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044877,GO:0046209,GO:0046394,GO:0046461,GO:0046464,GO:0046486,GO:0046503,GO:0046683,GO:0046872,GO:0048513,GO:0048545,GO:0048565,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0048878,GO:0050667,GO:0050801,GO:0050880,GO:0050896,GO:0051384,GO:0051591,GO:0051704,GO:0051707,GO:0051716,GO:0055081,GO:0055123,GO:0060416,GO:0060429,GO:0061008,GO:0065007,GO:0065008,GO:0070011,GO:0070013,GO:0070365,GO:0070408,GO:0070409,GO:0070542,GO:0070848,GO:0070887,GO:0071229,GO:0071310,GO:0071320,GO:0071363,GO:0071375,GO:0071377,GO:0071396,GO:0071398,GO:0071400,GO:0071407,GO:0071417,GO:0071495,GO:0071548,GO:0071704,GO:0071774,GO:0071941,GO:0072341,GO:0072593,GO:0090066,GO:0090407,GO:0097159,GO:0097237,GO:0097327,GO:0097367,GO:0097746,GO:0097755,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901607,GO:1901652,GO:1901653,GO:1901654,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1903717,GO:1903718,GO:2001057	6.3.4.16	ko:K01948	ko00220,ko00250,ko00910,ko01100,ko01120,ko01200,ko01230,map00220,map00250,map00910,map01100,map01120,map01200,map01230	M00029	R00149	RC00002,RC02804	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	CPSase_L_D2,CPSase_L_D3,CPSase_sm_chain,GATase,MGS,OTCace_N
SX3_k127_1883060_15	456442.Mboo_0402	4.668e-26	118.0	COG0642@1|root,arCOG02385@1|root,arCOG02385@2157|Archaea,arCOG06192@2157|Archaea,arCOG06193@2157|Archaea,2Y7U4@28890|Euryarchaeota,2NAJ0@224756|Methanomicrobia	224756|Methanomicrobia	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_4,PAS_9,Response_reg
SX3_k127_1883060_1	1128421.JAGA01000001_gene2223	1.857e-193	610.0	COG0673@1|root,COG0673@2|Bacteria,2NQJC@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX3_k127_1883060_3	1128421.JAGA01000001_gene2222	2.046e-174	551.0	COG1082@1|root,COG1082@2|Bacteria,2NQCG@2323|unclassified Bacteria	2|Bacteria	G	AP endonuclease family 2 C terminus	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
SX3_k127_1883060_12	1128421.JAGA01000001_gene2219	2.439e-81	280.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	5.1.3.30,5.1.3.31	ko:K18910	-	-	R10817,R10818	RC03111,RC03283	ko00000,ko01000	-	-	-	AP_endonuc_2
SX3_k127_1883060_11	1042156.CXIVA_15960	3.168e-82	290.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,24ATV@186801|Clostridia,36E3P@31979|Clostridiaceae	186801|Clostridia	C	PFAM Alcohol dehydrogenase	-	-	1.1.1.103,1.1.1.14	ko:K00008,ko:K00060	ko00040,ko00051,ko00260,ko01100,map00040,map00051,map00260,map01100	M00014	R00875,R01465,R01896	RC00085,RC00102,RC00525	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
SX3_k127_1883060_13	1123508.JH636442_gene4033	1.917e-71	252.0	28TQ4@1|root,2ZFXE@2|Bacteria,2J25I@203682|Planctomycetes	203682|Planctomycetes	S	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SX3_k127_1883060_7	1232453.BAIF02000098_gene3894	1.654e-120	398.0	COG1482@1|root,COG1482@2|Bacteria,1TSWG@1239|Firmicutes	2|Bacteria	G	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
SX3_k127_1883060_5	1128421.JAGA01000001_gene2218	4.003e-139	468.0	COG3842@1|root,COG3842@2|Bacteria,2NNU0@2323|unclassified Bacteria	2|Bacteria	E	ATPases associated with a variety of cellular activities	smoK	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
SX3_k127_1883060_6	1128421.JAGA01000001_gene2217	5.55e-137	473.0	COG3842@1|root,COG3842@2|Bacteria,2NNU0@2323|unclassified Bacteria	2|Bacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE
SX3_k127_1883060_9	1128421.JAGA01000001_gene2215	1.194e-117	387.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX3_k127_1883060_8	1128421.JAGA01000001_gene2214	5.281e-119	390.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	ko:K02025,ko:K15771	ko02010,map02010	M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
SX3_k127_1883060_4	1128421.JAGA01000001_gene2213	1.297e-167	540.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
SX3_k127_1883060_0	1499967.BAYZ01000077_gene870	1.115e-201	637.0	COG2407@1|root,COG2407@2|Bacteria	2|Bacteria	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_Isome,Fucose_iso_C
SX3_k127_1883060_2	1499967.BAYZ01000172_gene5770	9.302e-180	576.0	COG1070@1|root,COG1070@2|Bacteria	2|Bacteria	G	xylulokinase activity	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
SX3_k127_1883060_14	697281.Mahau_0032	8.902e-70	253.0	COG0407@1|root,COG0407@2|Bacteria,1V5KX@1239|Firmicutes,24IAR@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_1883060_10	247490.KSU1_B0663	6.232e-86	305.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,2J293@203682|Planctomycetes	203682|Planctomycetes	I	CoA enzyme activase uncharacterised domain (DUF2229)	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
SX3_k127_1888501_18	545694.TREPR_0887	4.519e-20	93.0	COG0629@1|root,COG0629@2|Bacteria,2J86A@203691|Spirochaetes	203691|Spirochaetes	L	Single-stranded DNA-binding protein	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
SX3_k127_1888501_2	1123274.KB899410_gene3574	1.051e-147	475.0	COG0115@1|root,COG0115@2|Bacteria,2J6WR@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
SX3_k127_1888501_1	573413.Spirs_3735	8.409e-155	527.0	COG0457@1|root,COG0457@2|Bacteria,2J5XG@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
SX3_k127_1888501_16	1480694.DC28_10185	2.009e-28	126.0	COG0296@1|root,COG0296@2|Bacteria,2J5AV@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM
SX3_k127_1888501_12	1047013.AQSP01000128_gene411	3.05e-37	155.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SX3_k127_1888501_13	573413.Spirs_0330	9.512e-37	155.0	COG0204@1|root,COG0204@2|Bacteria,2JAJG@203691|Spirochaetes	203691|Spirochaetes	I	PFAM Phospholipid glycerol acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
SX3_k127_1888501_0	744872.Spica_1974	0.0	1499.0	COG0209@1|root,COG0209@2|Bacteria,2J5M3@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC,Ribonuc_red_lgN
SX3_k127_1888501_8	1321815.HMPREF9193_01254	3.74e-49	202.0	2E9WN@1|root,3342D@2|Bacteria,2J71N@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1888501_7	1123274.KB899418_gene2368	1.115e-50	189.0	2F1GF@1|root,33UH0@2|Bacteria,2J6X5@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4037
SX3_k127_1888501_10	649831.L083_2377	4.705e-39	164.0	COG0642@1|root,COG5278@1|root,COG2205@2|Bacteria,COG5278@2|Bacteria,2HEM6@201174|Actinobacteria,4DGZI@85008|Micromonosporales	201174|Actinobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HAMP,HATPase_c,HisKA
SX3_k127_1888501_9	160799.PBOR_06665	2.1e-47	185.0	2ASZS@1|root,31IFG@2|Bacteria,1V50D@1239|Firmicutes,4HZ96@91061|Bacilli,26R48@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1888501_11	1499967.BAYZ01000088_gene5106	9.236e-38	149.0	COG0095@1|root,COG0095@2|Bacteria	2|Bacteria	H	Lipoate-protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
SX3_k127_1888501_3	530564.Psta_2908	4.234e-129	424.0	COG3635@1|root,COG3635@2|Bacteria,2IY5S@203682|Planctomycetes	203682|Planctomycetes	G	phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
SX3_k127_1888501_4	1123274.KB899410_gene3389	1.112e-104	355.0	2F1P1@1|root,33UPB@2|Bacteria,2J896@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1888501_5	665571.STHERM_c02880	8.977e-91	328.0	2CB4X@1|root,33R8E@2|Bacteria,2J66H@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1888501_14	665571.STHERM_c02890	7.607e-34	139.0	2AMN9@1|root,33WHF@2|Bacteria,2J7R4@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1888501_6	744872.Spica_2503	4.842e-76	274.0	2CAZD@1|root,342TQ@2|Bacteria,2J9GV@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1888501_17	4641.GSMUA_Achr9P17860_001	4.99e-25	119.0	COG1028@1|root,KOG0725@2759|Eukaryota,37S3J@33090|Viridiplantae,3GF7T@35493|Streptophyta,3KQT1@4447|Liliopsida	35493|Streptophyta	Q	Sex determination protein	-	-	3.6.4.12	ko:K15255	-	-	-	-	ko00000,ko01000,ko03029,ko03032	-	-	-	adh_short,adh_short_C2
SX3_k127_1888501_15	246194.CHY_2470	1.959e-28	118.0	COG0730@1|root,COG0730@2|Bacteria,1TPMA@1239|Firmicutes,249II@186801|Clostridia,42FVW@68295|Thermoanaerobacterales	186801|Clostridia	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
SX3_k127_1899928_23	1499967.BAYZ01000041_gene2361	2.24e-33	138.0	COG1638@1|root,COG1638@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K21395	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctP
SX3_k127_1899928_7	180332.JTGN01000002_gene5723	6.498e-127	413.0	COG1402@1|root,COG1402@2|Bacteria,1V0N8@1239|Firmicutes,24BWG@186801|Clostridia	186801|Clostridia	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470,ko:K22232	ko00330,ko00562,map00330,map00562	-	R01884,R11771	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
SX3_k127_1899928_32	469383.Cwoe_0193	2.828e-08	60.0	COG0662@1|root,COG0662@2|Bacteria,2GXJK@201174|Actinobacteria,4CT2T@84995|Rubrobacteria	84995|Rubrobacteria	G	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SX3_k127_1899928_10	1499967.BAYZ01000041_gene2362	2.46e-101	338.0	COG1028@1|root,COG1028@2|Bacteria	1499967.BAYZ01000041_gene2362|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1899928_4	868595.Desca_2486	1.802e-149	497.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,2604P@186807|Peptococcaceae	186801|Clostridia	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
SX3_k127_1899928_15	1408254.T458_26080	4.673e-69	247.0	COG2055@1|root,COG2055@2|Bacteria,1TR0Z@1239|Firmicutes,4HB6X@91061|Bacilli,26WJP@186822|Paenibacillaceae	91061|Bacilli	C	Malate/L-lactate dehydrogenase	-	-	1.1.1.350	ko:K00073	ko00230,ko01120,map00230,map01120	-	R02935,R02936	RC00169	ko00000,ko00001,ko01000	-	-	-	Ldh_2
SX3_k127_1899928_20	706587.Desti_3247	9.136e-48	183.0	COG0684@1|root,COG0684@2|Bacteria,1MW9P@1224|Proteobacteria,42VU3@68525|delta/epsilon subdivisions,2WRWJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Aldolase/RraA	-	-	4.1.3.17	ko:K10218	ko00362,ko00660,ko01120,map00362,map00660,map01120	-	R00008,R00350	RC00067,RC00502,RC01205	ko00000,ko00001,ko01000	-	-	-	RraA-like
SX3_k127_1899928_26	1343740.M271_06025	2.836e-24	111.0	COG1802@1|root,COG1802@2|Bacteria,2H1S8@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
SX3_k127_1899928_13	1382356.JQMP01000001_gene1176	9.817e-76	269.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
SX3_k127_1899928_30	443144.GM21_2934	2.551e-11	68.0	COG1977@1|root,COG1977@2|Bacteria,1QRAS@1224|Proteobacteria,43EYG@68525|delta/epsilon subdivisions,2X2KE@28221|Deltaproteobacteria,43VWD@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	ThiS family	-	-	-	-	-	-	-	-	-	-	-	-	ThiS
SX3_k127_1899928_17	351160.RRC447	1.051e-65	232.0	COG0476@1|root,arCOG01676@2157|Archaea,2XTYV@28890|Euryarchaeota,2N9IZ@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM UBA THIF-type NAD FAD binding protein	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
SX3_k127_1899928_19	428125.CLOLEP_01713	3.224e-49	182.0	COG0454@1|root,COG0456@2|Bacteria,1V1RG@1239|Firmicutes,24IJG@186801|Clostridia,3WMYA@541000|Ruminococcaceae	186801|Clostridia	K	Protease synthase and sporulation negative regulatory protein PAI 1	paiA	-	2.3.1.57	ko:K22441	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10
SX3_k127_1899928_9	1229172.JQFA01000002_gene4712	2.457e-105	359.0	COG1233@1|root,COG1233@2|Bacteria,1GCDS@1117|Cyanobacteria,1HDZU@1150|Oscillatoriales	1117|Cyanobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
SX3_k127_1899928_0	573413.Spirs_4305	0.0	1127.0	COG0188@1|root,COG0188@2|Bacteria,2J5NK@203691|Spirochaetes	203691|Spirochaetes	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
SX3_k127_1899928_1	744872.Spica_2869	5.168e-296	919.0	COG0187@1|root,COG0187@2|Bacteria,2J67M@203691|Spirochaetes	203691|Spirochaetes	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
SX3_k127_1899928_2	1480694.DC28_08975	7.939e-183	582.0	COG0593@1|root,COG0593@2|Bacteria,2J5F6@203691|Spirochaetes	203691|Spirochaetes	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
SX3_k127_1899928_6	573413.Spirs_0003	5.193e-134	436.0	COG0592@1|root,COG0592@2|Bacteria,2J629@203691|Spirochaetes	203691|Spirochaetes	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
SX3_k127_1899928_11	1123274.KB899423_gene1595	6.252e-99	336.0	COG1195@1|root,COG1195@2|Bacteria,2J5MP@203691|Spirochaetes	203691|Spirochaetes	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
SX3_k127_1899928_29	545694.TREPR_0273	2.464e-14	77.0	COG5512@1|root,COG5512@2|Bacteria,2J8RK@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
SX3_k127_1899928_27	545695.TREAZ_2143	2.236e-20	92.0	COG0230@1|root,COG0230@2|Bacteria,2J8S9@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
SX3_k127_1899928_33	477974.Daud_2237	2.824e-05	51.0	COG0594@1|root,COG0594@2|Bacteria,1VA78@1239|Firmicutes,24QK5@186801|Clostridia,262VE@186807|Peptococcaceae	186801|Clostridia	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
SX3_k127_1899928_25	755178.Cyan10605_0127	1.107e-28	116.0	COG0759@1|root,COG0759@2|Bacteria,1G90B@1117|Cyanobacteria	1117|Cyanobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
SX3_k127_1899928_5	1123274.KB899423_gene1599	5.508e-140	467.0	COG0706@1|root,COG0706@2|Bacteria,2J5HA@203691|Spirochaetes	203691|Spirochaetes	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
SX3_k127_1899928_18	545695.TREAZ_2139	2.403e-54	214.0	COG1847@1|root,COG1847@2|Bacteria,2J5S0@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Single-stranded nucleic acid binding R3H	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
SX3_k127_1899928_31	1187851.A33M_3395	3.967e-10	63.0	COG2331@1|root,COG2331@2|Bacteria,1Q4C9@1224|Proteobacteria,2UMSM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
SX3_k127_1899928_24	1307761.L21SP2_3452	8.405e-31	133.0	COG2430@1|root,COG2430@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF432
SX3_k127_1899928_14	744872.Spica_0456	3.283e-72	253.0	COG0668@1|root,COG0668@2|Bacteria,2J6IE@203691|Spirochaetes	203691|Spirochaetes	M	mechanosensitive ion channel	-	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel
SX3_k127_1899928_12	118161.KB235922_gene2311	1.907e-98	347.0	COG1819@1|root,COG1819@2|Bacteria,1G036@1117|Cyanobacteria	1117|Cyanobacteria	CG	Glycosyltransferase family 28 N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_28,UDPGT
SX3_k127_1899928_21	545243.BAEV01000006_gene1356	3.771e-37	147.0	COG1309@1|root,COG1309@2|Bacteria,1V9XJ@1239|Firmicutes,24I61@186801|Clostridia,36IR0@31979|Clostridiaceae	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
SX3_k127_1899928_22	941824.TCEL_00466	2.17e-33	147.0	COG0477@1|root,COG2814@2|Bacteria,1UZPE@1239|Firmicutes,2490R@186801|Clostridia,36EGS@31979|Clostridiaceae	186801|Clostridia	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_2,MFS_3
SX3_k127_1899928_8	665571.STHERM_c18190	1.274e-118	396.0	COG0673@1|root,COG0673@2|Bacteria,2J5J5@203691|Spirochaetes	203691|Spirochaetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
SX3_k127_1899928_3	1122927.KB895416_gene3403	1.985e-174	562.0	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,4H9YT@91061|Bacilli,26S4T@186822|Paenibacillaceae	91061|Bacilli	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
SX3_k127_1899928_28	697281.Mahau_2857	2.192e-18	91.0	COG0407@1|root,COG0407@2|Bacteria,1V2TK@1239|Firmicutes,24FVW@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_1899928_16	545695.TREAZ_3395	2.787e-68	241.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_1910936_7	1123274.KB899414_gene3650	5.778e-93	316.0	COG1692@1|root,COG1692@2|Bacteria,2J6ZK@203691|Spirochaetes	203691|Spirochaetes	S	YmdB-like protein	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
SX3_k127_1910936_0	744872.Spica_2763	3.478e-228	719.0	COG0504@1|root,COG0504@2|Bacteria,2J5AB@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
SX3_k127_1910936_14	889378.Spiaf_2674	5.019e-14	85.0	28XQQ@1|root,2ZJMD@2|Bacteria,2J8Q3@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	LptC
SX3_k127_1910936_10	889378.Spiaf_2673	2.433e-47	179.0	COG1934@1|root,COG1934@2|Bacteria,2J7U8@203691|Spirochaetes	203691|Spirochaetes	S	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm	-	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
SX3_k127_1910936_6	665571.STHERM_c21930	5.922e-105	346.0	COG1137@1|root,COG1137@2|Bacteria,2J5CM@203691|Spirochaetes	203691|Spirochaetes	S	ABC transporter, ATP-binding protein	lptB	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
SX3_k127_1910936_2	573413.Spirs_4048	8.303e-149	487.0	COG1508@1|root,COG1508@2|Bacteria,2J5KV@203691|Spirochaetes	203691|Spirochaetes	K	RNA polymerase sigma54 factor	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
SX3_k127_1910936_12	573413.Spirs_4049	7.993e-22	103.0	COG1544@1|root,COG1544@2|Bacteria,2J9DI@203691|Spirochaetes	203691|Spirochaetes	J	Sigma 54 modulation protein / S30EA ribosomal protein	-	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosomal_S30AE
SX3_k127_1910936_3	744872.Spica_2577	2.631e-137	445.0	COG1493@1|root,COG1493@2|Bacteria,2J5JA@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
SX3_k127_1910936_11	744872.Spica_2578	3.777e-29	118.0	COG1925@1|root,COG1925@2|Bacteria,2J8NY@203691|Spirochaetes	203691|Spirochaetes	G	phosphocarrier protein HPr	ptsH-2	-	-	ko:K02784,ko:K11189	ko02060,map02060	-	-	-	ko00000,ko00001,ko02000	4.A.2.1,8.A.8.1.1	-	-	PTS-HPr
SX3_k127_1910936_5	889378.Spiaf_2666	4.18e-127	435.0	COG5000@1|root,COG5000@2|Bacteria,2J753@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase	ntrY	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
SX3_k127_1910936_1	665571.STHERM_c22000	1.588e-171	577.0	COG2204@1|root,COG2204@2|Bacteria,2J63G@203691|Spirochaetes	203691|Spirochaetes	T	Regulatory protein	-	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
SX3_k127_1910936_9	1307761.L21SP2_3290	1.043e-69	245.0	COG1974@1|root,COG1974@2|Bacteria,2J7ID@203691|Spirochaetes	203691|Spirochaetes	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
SX3_k127_1910936_8	573413.Spirs_4056	1.08e-78	283.0	COG1466@1|root,COG1466@2|Bacteria,2J6PN@203691|Spirochaetes	203691|Spirochaetes	L	DNA polymerase III delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
SX3_k127_1910936_15	1305735.JAFT01000005_gene3372	1.492e-13	84.0	COG1879@1|root,COG1879@2|Bacteria,1MXJS@1224|Proteobacteria,2TTHJ@28211|Alphaproteobacteria,2PEUM@252301|Oceanicola	28211|Alphaproteobacteria	G	Periplasmic binding protein domain	ytfQ	GO:0003674,GO:0005215,GO:0005488,GO:0005534,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0015144,GO:0015145,GO:0015749,GO:0015757,GO:0016020,GO:0016021,GO:0022857,GO:0030246,GO:0030288,GO:0030313,GO:0031224,GO:0031975,GO:0034219,GO:0036094,GO:0042597,GO:0044425,GO:0044464,GO:0048029,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944	-	ko:K02058,ko:K10439,ko:K17213	ko02010,ko02030,map02010,map02030	M00212,M00221,M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
SX3_k127_1910936_13	398512.JQKC01000014_gene1526	2.169e-19	103.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V2BS@1239|Firmicutes,25B4R@186801|Clostridia,3WS5J@541000|Ruminococcaceae	186801|Clostridia	T	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,HTH_AraC,Response_reg
SX3_k127_1910936_4	266117.Rxyl_3003	1.065e-133	443.0	COG1129@1|root,COG1129@2|Bacteria,2GJ3F@201174|Actinobacteria,4CP7R@84995|Rubrobacteria	201174|Actinobacteria	P	PFAM ABC transporter related	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
SX3_k127_1915127_10	410358.Mlab_1320	5.006e-50	181.0	COG0739@1|root,arCOG11616@2157|Archaea,2XUVQ@28890|Euryarchaeota,2NAIV@224756|Methanomicrobia	224756|Methanomicrobia	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
SX3_k127_1915127_12	1536774.H70357_27195	6.183e-48	181.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
SX3_k127_1915127_18	744872.Spica_0910	5.539e-07	52.0	COG0399@1|root,COG0399@2|Bacteria,2JA54@203691|Spirochaetes	203691|Spirochaetes	M	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
SX3_k127_1915127_16	383372.Rcas_1471	1.256e-15	78.0	COG2963@1|root,COG2963@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	ko:K07483,ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve
SX3_k127_1915127_20	640511.BC1002_4618	2.357e-05	51.0	COG2801@1|root,COG2801@2|Bacteria,1MY62@1224|Proteobacteria,2VJAF@28216|Betaproteobacteria,1K2XD@119060|Burkholderiaceae	28216|Betaproteobacteria	L	transposase	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
SX3_k127_1915127_19	1408303.JNJJ01000091_gene2446	1.32e-05	56.0	COG2801@1|root,COG2801@2|Bacteria,1TQH6@1239|Firmicutes,4HCUT@91061|Bacilli,1ZR3S@1386|Bacillus	91061|Bacilli	L	Mu transposase, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,Mu-transpos_C,rve
SX3_k127_1915127_2	1307761.L21SP2_2067	9.888e-99	333.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_28,HTH_32,Mu-transpos_C,rve
SX3_k127_1915127_5	909663.KI867150_gene1310	4.587e-84	286.0	COG3267@1|root,COG3267@2|Bacteria,1REWJ@1224|Proteobacteria,42Y9C@68525|delta/epsilon subdivisions,2WUJJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
SX3_k127_1915127_15	443143.GM18_2768	4.642e-17	87.0	COG4584@1|root,COG4584@2|Bacteria,1MW5J@1224|Proteobacteria,42X93@68525|delta/epsilon subdivisions,2WSXR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
SX3_k127_1915127_8	717606.PaecuDRAFT_4193	2.457e-60	228.0	COG1404@1|root,COG2340@1|root,COG1404@2|Bacteria,COG2340@2|Bacteria,1V1IM@1239|Firmicutes,4HRX1@91061|Bacilli,26UWX@186822|Paenibacillaceae	91061|Bacilli	O	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	CAP,SLH
SX3_k127_1915127_6	1173028.ANKO01000116_gene5719	3.66e-80	274.0	COG2114@1|root,COG2114@2|Bacteria,1G6D6@1117|Cyanobacteria,1HB2S@1150|Oscillatoriales	1117|Cyanobacteria	T	COGs COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain)	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
SX3_k127_1915127_13	1234679.BN424_2482	3.856e-36	141.0	COG5646@1|root,COG5646@2|Bacteria,1V6QB@1239|Firmicutes,4HINV@91061|Bacilli	91061|Bacilli	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
SX3_k127_1915127_11	1307761.L21SP2_2222	5.106e-48	194.0	2EG9W@1|root,33A1P@2|Bacteria,2J9F9@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1915127_7	1480694.DC28_12415	2.286e-65	232.0	COG2834@1|root,COG2834@2|Bacteria,2J7Z0@203691|Spirochaetes	203691|Spirochaetes	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
SX3_k127_1915127_4	1480694.DC28_12410	2.021e-93	327.0	COG4591@1|root,COG4591@2|Bacteria,2JA02@203691|Spirochaetes	203691|Spirochaetes	M	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX3_k127_1915127_0	1480694.DC28_12405	9.62e-118	391.0	COG4591@1|root,COG4591@2|Bacteria,2J7QZ@203691|Spirochaetes	203691|Spirochaetes	M	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX3_k127_1915127_3	158189.SpiBuddy_2774	9.996e-96	318.0	COG1136@1|root,COG1136@2|Bacteria,2J7FN@203691|Spirochaetes	203691|Spirochaetes	V	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003,ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_1915127_1	158189.SpiBuddy_2773	3.919e-115	382.0	COG0330@1|root,COG0330@2|Bacteria,2J73X@203691|Spirochaetes	203691|Spirochaetes	O	PFAM SPFH domain Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
SX3_k127_1915127_9	1480694.DC28_12390	3.041e-50	181.0	COG1725@1|root,COG1725@2|Bacteria,2J9B8@203691|Spirochaetes	203691|Spirochaetes	K	transcriptional regulator	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
SX3_k127_1974517_1	335543.Sfum_1073	4.785e-219	687.0	COG4868@1|root,COG4868@2|Bacteria,1NN03@1224|Proteobacteria,42P46@68525|delta/epsilon subdivisions,2WKVV@28221|Deltaproteobacteria,2MR6J@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1846)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1846
SX3_k127_1974517_28	383372.Rcas_3922	3.623e-18	87.0	COG1708@1|root,COG1708@2|Bacteria,2G9B2@200795|Chloroflexi	200795|Chloroflexi	L	DNA polymerase beta domain protein region	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
SX3_k127_1974517_27	926550.CLDAP_16770	1.508e-20	98.0	COG2250@1|root,COG2250@2|Bacteria	2|Bacteria	S	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
SX3_k127_1974517_3	1499967.BAYZ01000062_gene6036	2.508e-136	470.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria	2|Bacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12,TPR_16,TPR_7,TPR_8
SX3_k127_1974517_4	565033.GACE_1704	8.411e-117	392.0	COG0277@1|root,arCOG00337@2157|Archaea,2XT5C@28890|Euryarchaeota,245UV@183980|Archaeoglobi	183980|Archaeoglobi	C	Glycolate oxidase subunit (GlcD)	-	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0036094,GO:0043167,GO:0043168,GO:0047809,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.1.3.15,1.1.99.6	ko:K00104,ko:K21836	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
SX3_k127_1974517_12	545694.TREPR_2780	3.561e-92	330.0	COG0457@1|root,COG1652@1|root,COG0457@2|Bacteria,COG1652@2|Bacteria,2J7YH@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1974517_17	660470.Theba_2350	6.237e-73	263.0	COG0833@1|root,COG0833@2|Bacteria	2|Bacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
SX3_k127_1974517_34	3218.PP1S20_204V6.1	5.409e-10	71.0	28I1Z@1|root,2QQCN@2759|Eukaryota,37MX3@33090|Viridiplantae,3GB6R@35493|Streptophyta	35493|Streptophyta	S	N-acetyltransferase	-	GO:0000902,GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006807,GO:0007154,GO:0007165,GO:0007275,GO:0008080,GO:0008150,GO:0008152,GO:0009314,GO:0009416,GO:0009628,GO:0009639,GO:0009640,GO:0009653,GO:0009719,GO:0009723,GO:0009725,GO:0009733,GO:0009734,GO:0009755,GO:0009791,GO:0009826,GO:0009987,GO:0010033,GO:0016043,GO:0016049,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0023052,GO:0032501,GO:0032502,GO:0032870,GO:0032989,GO:0036211,GO:0040007,GO:0042221,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0048589,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060560,GO:0065007,GO:0070887,GO:0071310,GO:0071365,GO:0071495,GO:0071704,GO:0071840,GO:1901564	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SX3_k127_1974517_37	192952.MM_0391	0.0009868	47.0	COG5276@1|root,arCOG02565@2157|Archaea	2157|Archaea	O	LVIVD repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
SX3_k127_1974517_0	889378.Spiaf_0306	8.095e-293	942.0	COG1391@1|root,COG1391@2|Bacteria	2|Bacteria	H	[glutamate-ammonia-ligase] adenylyltransferase activity	glnE	GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
SX3_k127_1974517_32	1111479.AXAR01000006_gene710	5.721e-13	79.0	COG3118@1|root,COG3118@2|Bacteria,1VEPC@1239|Firmicutes,4HNXE@91061|Bacilli	91061|Bacilli	O	general stress protein	ytxJ	-	-	-	-	-	-	-	-	-	-	-	DUF2847
SX3_k127_1974517_6	926569.ANT_02890	2.479e-108	359.0	COG1738@1|root,COG1738@2|Bacteria,2G6BZ@200795|Chloroflexi	200795|Chloroflexi	S	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage	-	-	-	ko:K09125	-	-	-	-	ko00000	-	-	-	Vut_1
SX3_k127_1974517_18	1480694.DC28_15190	3.838e-72	256.0	COG0569@1|root,COG0569@2|Bacteria,2J7SR@203691|Spirochaetes	203691|Spirochaetes	C	TrkA-N domain	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
SX3_k127_1974517_5	1480694.DC28_15195	4.5e-116	389.0	COG0168@1|root,COG0168@2|Bacteria,2J5NF@203691|Spirochaetes	203691|Spirochaetes	P	Potassium uptake protein, TrkH family	ntpJ	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
SX3_k127_1974517_23	1297617.JPJD01000043_gene1775	5.807e-43	167.0	28NVW@1|root,2ZBTV@2|Bacteria,1VR7H@1239|Firmicutes,24MK4@186801|Clostridia,26A2Y@186813|unclassified Clostridiales	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1974517_25	1122179.KB890447_gene300	6.153e-40	158.0	28NVW@1|root,2ZBTV@2|Bacteria,4NMGC@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1974517_14	1499967.BAYZ01000104_gene3651	3.02e-83	293.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
SX3_k127_1974517_13	1499967.BAYZ01000104_gene3650	8.148e-88	300.0	COG1175@1|root,COG1175@2|Bacteria,2NPDA@2323|unclassified Bacteria	2|Bacteria	G	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K15771	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
SX3_k127_1974517_16	1499967.BAYZ01000104_gene3649	2.17e-77	268.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX3_k127_1974517_24	1265505.ATUG01000001_gene4495	1.005e-40	168.0	COG5598@1|root,COG5598@2|Bacteria,1MWJN@1224|Proteobacteria,42Q8R@68525|delta/epsilon subdivisions,2WMDK@28221|Deltaproteobacteria,2MJEG@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Trimethylamine methyltransferase	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
SX3_k127_1974517_36	572478.Vdis_1575	9.892e-05	51.0	COG1917@1|root,arCOG02994@2157|Archaea,2XR3G@28889|Crenarchaeota	28889|Crenarchaeota	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SX3_k127_1974517_29	641107.CDLVIII_3547	8.442e-16	86.0	COG1917@1|root,COG1917@2|Bacteria,1V8SS@1239|Firmicutes,24KI9@186801|Clostridia,36PAT@31979|Clostridiaceae	186801|Clostridia	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SX3_k127_1974517_31	658086.HMPREF0994_03473	7.966e-14	85.0	COG0407@1|root,COG0407@2|Bacteria,1TSSK@1239|Firmicutes,24CHA@186801|Clostridia,27SEH@186928|unclassified Lachnospiraceae	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_1974517_19	1499967.BAYZ01000155_gene633	1.324e-69	261.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
SX3_k127_1974517_21	344747.PM8797T_13832	4.812e-47	188.0	COG2159@1|root,COG2159@2|Bacteria,2IYFQ@203682|Planctomycetes	203682|Planctomycetes	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
SX3_k127_1974517_10	1499967.BAYZ01000118_gene3280	6.597e-96	321.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX3_k127_1974517_11	1499967.BAYZ01000118_gene3279	6.779e-93	316.0	COG1175@1|root,COG1175@2|Bacteria,2NPDA@2323|unclassified Bacteria	2|Bacteria	G	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025,ko:K15771	ko02010,map02010	M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
SX3_k127_1974517_7	1499967.BAYZ01000118_gene3278	2.991e-105	357.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
SX3_k127_1974517_22	886293.Sinac_4562	2.29e-44	177.0	COG1904@1|root,COG1904@2|Bacteria,2J28E@203682|Planctomycetes	203682|Planctomycetes	G	glucuronate isomerase	-	-	5.3.1.12	ko:K01812	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	-
SX3_k127_1974517_8	1382304.JNIL01000001_gene2451	3.181e-99	340.0	COG2942@1|root,COG2942@2|Bacteria	2|Bacteria	G	2-epimerase	-	-	5.1.3.11,5.1.3.8	ko:K01787,ko:K16213	ko00520,map00520	-	R01207,R01445,R10810	RC00289,RC00290	ko00000,ko00001,ko01000	-	-	-	GlcNAc_2-epim,Prenyltrans
SX3_k127_1974517_33	1123075.AUDP01000041_gene331	1.573e-11	76.0	COG0407@1|root,COG0407@2|Bacteria,1TSSK@1239|Firmicutes,24CHA@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_1974517_15	545694.TREPR_2780	5.337e-83	304.0	COG0457@1|root,COG1652@1|root,COG0457@2|Bacteria,COG1652@2|Bacteria,2J7YH@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1974517_30	744872.Spica_2496	1.334e-14	76.0	COG0607@1|root,COG0607@2|Bacteria,2J8B4@203691|Spirochaetes	203691|Spirochaetes	P	Rhodanese Homology Domain	glpE	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
SX3_k127_1974517_2	1174528.JH992898_gene3506	3.187e-182	587.0	COG5421@1|root,COG5421@2|Bacteria,1G3YW@1117|Cyanobacteria	1117|Cyanobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
SX3_k127_1974517_9	192952.MM_0391	2.026e-96	349.0	COG5276@1|root,arCOG02565@2157|Archaea	2157|Archaea	O	LVIVD repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
SX3_k127_1974517_20	545694.TREPR_0042	2.325e-51	207.0	COG0457@1|root,COG0457@2|Bacteria,2J7YH@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2114651_3	744872.Spica_2509	4.114e-48	178.0	COG0778@1|root,COG0778@2|Bacteria,2J8VG@203691|Spirochaetes	203691|Spirochaetes	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
SX3_k127_2114651_2	665571.STHERM_c20940	1.264e-71	250.0	2EYA0@1|root,33RIG@2|Bacteria,2J6Q4@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2114651_0	604354.TSIB_0718	2.473e-135	451.0	COG0477@1|root,arCOG00143@2157|Archaea,2Y8EH@28890|Euryarchaeota,245MX@183968|Thermococci	183968|Thermococci	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX3_k127_2114651_1	744872.Spica_1809	1.207e-90	315.0	COG0265@1|root,COG0265@2|Bacteria,2J5GT@203691|Spirochaetes	203691|Spirochaetes	O	periplasmic serine protease, Do	htrA	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
SX3_k127_2118280_16	1480694.DC28_07915	2.03e-65	233.0	COG1752@1|root,COG1752@2|Bacteria,2J6JW@203691|Spirochaetes	203691|Spirochaetes	M	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,Patatin
SX3_k127_2118280_28	748449.Halha_1223	4.257e-23	102.0	COG0694@1|root,COG0694@2|Bacteria,1VAAU@1239|Firmicutes,24R29@186801|Clostridia,3WAXG@53433|Halanaerobiales	186801|Clostridia	O	PFAM NifU-like domain	-	-	-	-	-	-	-	-	-	-	-	-	NifU
SX3_k127_2118280_21	690850.Desaf_3320	7.844e-52	186.0	COG2033@1|root,COG2033@2|Bacteria,1QNA5@1224|Proteobacteria,435XP@68525|delta/epsilon subdivisions,2X0EC@28221|Deltaproteobacteria,2MC18@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Desulfoferrodoxin	-	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrodox
SX3_k127_2118280_24	1219084.AP014508_gene775	1.096e-46	173.0	COG1528@1|root,COG1528@2|Bacteria,2GD4M@200918|Thermotogae	200918|Thermotogae	P	Iron-storage protein	-	-	1.16.3.2	ko:K02217	-	-	-	-	ko00000,ko01000	-	-	-	Ferritin
SX3_k127_2118280_26	1121451.DESAM_21216	2.478e-28	117.0	COG3695@1|root,COG3695@2|Bacteria,1PZ1K@1224|Proteobacteria,42WV5@68525|delta/epsilon subdivisions,2WT08@28221|Deltaproteobacteria,2MGUT@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	-	ko:K07443	-	-	-	-	ko00000	-	-	-	DNA_binding_1
SX3_k127_2118280_29	744872.Spica_0543	1.873e-21	109.0	2DQ94@1|root,335DB@2|Bacteria,2J7K8@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2118280_5	744872.Spica_0542	1.927e-160	529.0	COG1172@1|root,COG1172@2|Bacteria,2J5CE@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
SX3_k127_2118280_4	744872.Spica_0541	5.795e-167	533.0	COG1172@1|root,COG1172@2|Bacteria,2J5SV@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
SX3_k127_2118280_0	744872.Spica_0540	1.631e-254	802.0	COG1129@1|root,COG1129@2|Bacteria,2J67Y@203691|Spirochaetes	203691|Spirochaetes	G	ABC transporter	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
SX3_k127_2118280_1	744872.Spica_0497	5.889e-211	661.0	COG1609@1|root,COG1609@2|Bacteria,2J5E7@203691|Spirochaetes	203691|Spirochaetes	K	Protein of unknown function (DUF3798)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3798
SX3_k127_2118280_20	443144.GM21_2073	4.529e-52	192.0	COG2930@1|root,COG2930@2|Bacteria,1RHV6@1224|Proteobacteria,42TN0@68525|delta/epsilon subdivisions,2WQ75@28221|Deltaproteobacteria,43UMS@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
SX3_k127_2118280_11	378806.STAUR_0766	1.394e-104	349.0	COG0667@1|root,COG0667@2|Bacteria,1R8HH@1224|Proteobacteria	1224|Proteobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SX3_k127_2118280_22	545694.TREPR_1573	2.076e-51	197.0	COG0477@1|root,COG2814@2|Bacteria,2J7NT@203691|Spirochaetes	203691|Spirochaetes	EGP	Major Facilitator	-	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
SX3_k127_2118280_17	331113.SNE_A22970	2.617e-63	233.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	-	-	-	-	-	-	-	-	-	AAA_14,DUF4143
SX3_k127_2118280_31	515635.Dtur_0157	5.176e-11	72.0	COG1486@1|root,COG1486@2|Bacteria	2|Bacteria	G	melibiose metabolic process	-	-	3.2.1.22,3.2.1.86	ko:K01222,ko:K07406	ko00010,ko00052,ko00500,ko00561,ko00600,ko00603,map00010,map00052,map00500,map00561,map00600,map00603	-	R00839,R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05133,R05134,R05549,R05961,R06091	RC00049,RC00059,RC00171,RC00451,RC00714	ko00000,ko00001,ko01000	-	GT4	-	Glyco_hydro_4,Glyco_hydro_4C
SX3_k127_2118280_15	1379270.AUXF01000001_gene2605	1.002e-83	289.0	COG0613@1|root,COG0613@2|Bacteria	2|Bacteria	Q	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2118280_13	555088.DealDRAFT_2005	1.193e-94	323.0	COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,24BAN@186801|Clostridia	186801|Clostridia	G	M42 glutamyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
SX3_k127_2118280_12	867903.ThesuDRAFT_01176	5.339e-99	335.0	COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,248D0@186801|Clostridia	186801|Clostridia	G	M42 glutamyl aminopeptidase	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Peptidase_M42
SX3_k127_2118280_8	926569.ANT_05540	7.799e-120	393.0	COG1363@1|root,COG1363@2|Bacteria,2G6EE@200795|Chloroflexi	200795|Chloroflexi	G	peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
SX3_k127_2118280_14	886293.Sinac_6174	3.189e-90	308.0	COG0598@1|root,COG0598@2|Bacteria,2IX61@203682|Planctomycetes	203682|Planctomycetes	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
SX3_k127_2118280_7	1459636.NTE_01726	1.753e-145	471.0	COG0192@1|root,arCOG07444@2157|Archaea,41S5P@651137|Thaumarchaeota	651137|Thaumarchaeota	H	S-adenosylmethionine synthetase	-	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
SX3_k127_2118280_6	28072.Nos7524_4720	9.111e-147	481.0	COG1253@1|root,COG1253@2|Bacteria,1G16U@1117|Cyanobacteria,1HISP@1161|Nostocales	1117|Cyanobacteria	S	PFAM CBS domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
SX3_k127_2118280_33	518766.Rmar_1952	4.076e-08	57.0	COG0432@1|root,COG0432@2|Bacteria,4NUS2@976|Bacteroidetes,1FK5X@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
SX3_k127_2118280_30	660470.Theba_0404	1.352e-16	90.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
SX3_k127_2118280_23	545694.TREPR_3442	5.96e-48	181.0	COG1496@1|root,COG1496@2|Bacteria,2J7NB@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the multicopper oxidase YfiH RL5 family	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
SX3_k127_2118280_25	203119.Cthe_2515	2.212e-46	172.0	COG0590@1|root,COG0590@2|Bacteria,1V7G0@1239|Firmicutes,24PS1@186801|Clostridia,3WRX4@541000|Ruminococcaceae	186801|Clostridia	FJ	MafB19-like deaminase	-	-	3.5.4.3	ko:K01487	ko00230,ko01100,map00230,map01100	-	R01676	RC00204	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
SX3_k127_2118280_19	1137269.AZWL01000001_gene5870	6.789e-54	205.0	COG0673@1|root,COG0673@2|Bacteria,2GM7J@201174|Actinobacteria	201174|Actinobacteria	K	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX3_k127_2118280_2	1304880.JAGB01000002_gene1930	1.038e-201	640.0	COG0673@1|root,COG0673@2|Bacteria,1TSUT@1239|Firmicutes,24DAD@186801|Clostridia	186801|Clostridia	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX3_k127_2118280_3	28583.AMAG_09412T0	1.216e-179	601.0	COG0334@1|root,KOG2250@2759|Eukaryota,390UX@33154|Opisthokonta,3NVNH@4751|Fungi	4751|Fungi	E	NAD( )-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate	GDH2	GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006103,GO:0006106,GO:0006520,GO:0006536,GO:0006538,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0016639,GO:0019551,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0051186,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH,ELFV_dehydrog
SX3_k127_2118280_10	1304880.JAGB01000001_gene547	6.652e-106	357.0	COG0454@1|root,COG0456@2|Bacteria,1TT30@1239|Firmicutes,24DE0@186801|Clostridia	186801|Clostridia	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SX3_k127_2118280_9	909663.KI867150_gene2881	2.459e-111	385.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42QJF@68525|delta/epsilon subdivisions,2WJ9D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,Response_reg
SX3_k127_2118280_32	765420.OSCT_0029	5.278e-11	72.0	COG0745@1|root,COG0745@2|Bacteria	765420.OSCT_0029|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2118280_27	1499967.BAYZ01000059_gene4769	1.561e-23	106.0	COG0745@1|root,COG0745@2|Bacteria,2NRCE@2323|unclassified Bacteria	2|Bacteria	KT	cheY-homologous receiver domain	-	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
SX3_k127_2118280_18	909663.KI867150_gene2879	2.955e-63	226.0	COG4191@1|root,COG4624@1|root,COG4191@2|Bacteria,COG4624@2|Bacteria,1RCM9@1224|Proteobacteria,42MIZ@68525|delta/epsilon subdivisions,2WIUX@28221|Deltaproteobacteria,2MQZB@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Integral membrane sensor signal transduction histidine kinase	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,dCache_1
SX3_k127_218133_2	177437.HRM2_41440	1.84e-08	60.0	COG0399@1|root,COG0399@2|Bacteria,1PRVB@1224|Proteobacteria,431RA@68525|delta/epsilon subdivisions,2X518@28221|Deltaproteobacteria,2MP3U@213118|Desulfobacterales	28221|Deltaproteobacteria	M	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp
SX3_k127_218133_1	158189.SpiBuddy_2684	3.878e-13	79.0	COG0426@1|root,COG2199@1|root,COG0426@2|Bacteria,COG2199@2|Bacteria,COG3706@2|Bacteria,2J57P@203691|Spirochaetes	203691|Spirochaetes	C	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Lactamase_B,Response_reg
SX3_k127_218133_0	1201290.M902_2020	5.772e-25	117.0	COG3210@1|root,COG3210@2|Bacteria,1NGFP@1224|Proteobacteria,43EIP@68525|delta/epsilon subdivisions,2X8HE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Chaperone of endosialidase	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	Peptidase_S74
SX3_k127_2184911_6	1125700.HMPREF9195_00502	5.309e-17	83.0	COG0629@1|root,COG0629@2|Bacteria,2J86A@203691|Spirochaetes	203691|Spirochaetes	L	Single-stranded DNA-binding protein	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
SX3_k127_2184911_9	1250005.PHEL85_1495	7.138e-07	53.0	COG0604@1|root,COG0604@2|Bacteria,4NEYW@976|Bacteroidetes,1HYX1@117743|Flavobacteriia,3VVTR@52959|Polaribacter	976|Bacteroidetes	C	Alcohol dehydrogenase GroES-like domain	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2,MaoC_dehydratas
SX3_k127_2184911_4	1220534.B655_1327	4.403e-32	133.0	COG0716@1|root,arCOG00519@2157|Archaea,2XXTN@28890|Euryarchaeota	28890|Euryarchaeota	C	Flavodoxin	-	GO:0000166,GO:0003674,GO:0003824,GO:0004729,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0010181,GO:0016491,GO:0016627,GO:0016634,GO:0016635,GO:0018130,GO:0019438,GO:0032553,GO:0033013,GO:0033014,GO:0034641,GO:0036094,GO:0042168,GO:0042440,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0070818,GO:0070819,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	-	-	-	-	-	-	-	-	-	Flavodoxin_3,Flavodoxin_5
SX3_k127_2184911_1	268407.PWYN_18010	1.647e-43	172.0	2DBV7@1|root,2ZB9P@2|Bacteria,1UBN2@1239|Firmicutes,4HEYF@91061|Bacilli,26VBW@186822|Paenibacillaceae	91061|Bacilli	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
SX3_k127_2184911_5	1125699.HMPREF9194_01806	7.276e-29	125.0	2FJPE@1|root,34BCJ@2|Bacteria,2J9EU@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2184911_7	1273538.G159_04940	4.801e-15	84.0	2DNVA@1|root,32ZBE@2|Bacteria,1W480@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2184911_2	1117108.PAALTS15_18273	4.641e-42	164.0	2DBV7@1|root,2ZB9P@2|Bacteria,1UBN2@1239|Firmicutes,4HEYF@91061|Bacilli,26VBW@186822|Paenibacillaceae	91061|Bacilli	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
SX3_k127_2184911_8	1273538.G159_04940	3.779e-14	76.0	2DNVA@1|root,32ZBE@2|Bacteria,1W480@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2184911_0	485913.Krac_0278	1.572e-75	263.0	COG0604@1|root,COG0604@2|Bacteria,2G84Q@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
SX3_k127_221385_21	323261.Noc_3018	2.064e-06	51.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales	135613|Chromatiales	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_8
SX3_k127_221385_9	665571.STHERM_c21800	6.896e-59	212.0	COG0791@1|root,COG0791@2|Bacteria,2JB19@203691|Spirochaetes	203691|Spirochaetes	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	CHAP,NLPC_P60
SX3_k127_221385_14	1484460.JSWG01000012_gene1574	2.563e-27	125.0	COG5580@1|root,COG5580@2|Bacteria,4PK53@976|Bacteroidetes,1I3SX@117743|Flavobacteriia	976|Bacteroidetes	O	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
SX3_k127_221385_10	768710.DesyoDRAFT_3295	3.973e-55	216.0	COG0778@1|root,COG0778@2|Bacteria,1V0NJ@1239|Firmicutes,24FM7@186801|Clostridia,261PI@186807|Peptococcaceae	186801|Clostridia	C	PFAM Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	TM1586_NiRdase
SX3_k127_221385_6	1123288.SOV_2c00620	2.022e-105	350.0	COG2358@1|root,COG2358@2|Bacteria,1TPXW@1239|Firmicutes,4H2B2@909932|Negativicutes	909932|Negativicutes	S	TRAP transporter solute receptor TAXI family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
SX3_k127_221385_19	1209989.TepiRe1_0868	9.958e-10	67.0	COG4729@1|root,COG4729@2|Bacteria,1VBFA@1239|Firmicutes,24VP6@186801|Clostridia,42INT@68295|Thermoanaerobacterales	186801|Clostridia	S	Domain of unknown function (DUF1850)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1850
SX3_k127_221385_0	546271.Selsp_1584	1.049e-213	683.0	COG4666@1|root,COG4666@2|Bacteria,1TP0V@1239|Firmicutes,4H3FG@909932|Negativicutes	909932|Negativicutes	S	TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
SX3_k127_221385_4	665571.STHERM_c21630	1.78e-113	400.0	COG2211@1|root,COG2211@2|Bacteria,2J6P4@203691|Spirochaetes	203691|Spirochaetes	G	transporter	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX3_k127_221385_13	748727.CLJU_c17460	2.199e-27	123.0	COG2909@1|root,COG2909@2|Bacteria	2|Bacteria	K	trisaccharide binding	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	Abhydrolase_1,GerE
SX3_k127_221385_15	1123373.ATXI01000003_gene1378	5.7e-23	107.0	COG3103@1|root,COG4991@2|Bacteria,2GHRI@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	sh3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_221385_7	871963.Desdi_0372	3.355e-76	262.0	COG0348@1|root,COG0348@2|Bacteria,1UVRB@1239|Firmicutes,25I6A@186801|Clostridia,266AF@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_9
SX3_k127_221385_20	215803.DB30_5198	5.645e-09	68.0	2A7XS@1|root,30WXJ@2|Bacteria,1PBJA@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_221385_17	452637.Oter_2886	5.398e-17	94.0	COG0407@1|root,COG0407@2|Bacteria,46WW7@74201|Verrucomicrobia,3K8TQ@414999|Opitutae	414999|Opitutae	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
SX3_k127_221385_2	697281.Mahau_1208	8.446e-171	545.0	COG0407@1|root,COG0407@2|Bacteria,1UY51@1239|Firmicutes,24DZF@186801|Clostridia,42FW9@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_221385_3	661478.OP10G_4223	1.522e-127	422.0	COG3754@1|root,COG3754@2|Bacteria	2|Bacteria	M	Rhamnan synthesis protein F	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_WbsX,RgpF
SX3_k127_221385_11	1235457.C404_15395	7.046e-48	194.0	COG1609@1|root,COG1609@2|Bacteria,1MVUR@1224|Proteobacteria,2VMHY@28216|Betaproteobacteria,1K10M@119060|Burkholderiaceae	28216|Betaproteobacteria	K	periplasmic binding protein LacI transcriptional regulator	rbsR	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
SX3_k127_221385_12	1095772.CAHH01000016_gene910	1.353e-30	134.0	COG0395@1|root,COG0395@2|Bacteria,2GM2W@201174|Actinobacteria	201174|Actinobacteria	G	Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
SX3_k127_221385_8	658086.HMPREF0994_01751	2.977e-60	222.0	COG1175@1|root,COG1175@2|Bacteria,1TP1Q@1239|Firmicutes,24ADV@186801|Clostridia,27S04@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
SX3_k127_221385_18	1394178.AWOO02000016_gene6928	7.495e-12	78.0	COG1653@1|root,COG1653@2|Bacteria,2GP9H@201174|Actinobacteria,4EHAS@85012|Streptosporangiales	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8
SX3_k127_221385_5	240292.Ava_C0001	2.129e-110	372.0	COG0477@1|root,COG0477@2|Bacteria,1GHCR@1117|Cyanobacteria,1HKQS@1161|Nostocales	1117|Cyanobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
SX3_k127_221385_1	760568.Desku_1635	9.032e-179	566.0	COG1063@1|root,COG1063@2|Bacteria,1UY6M@1239|Firmicutes,24AX0@186801|Clostridia	186801|Clostridia	E	Alcohol dehydrogenase GroES-like domain	-	-	-	ko:K22231	ko00562,map00562	-	R11770	-	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
SX3_k127_2307015_0	1307761.L21SP2_0435	9.19e-184	590.0	COG2114@1|root,COG2114@2|Bacteria,2J6Q9@203691|Spirochaetes	203691|Spirochaetes	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP,Response_reg
SX3_k127_2307015_1	1307761.L21SP2_0440	5.729e-44	173.0	2C0A1@1|root,33WBM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2350104_0	1123274.KB899409_gene630	1.359e-186	593.0	COG1900@1|root,COG1900@2|Bacteria,2J6WE@203691|Spirochaetes	203691|Spirochaetes	S	Homocysteine biosynthesis enzyme, sulfur-incorporation	-	-	-	-	-	-	-	-	-	-	-	-	HcyBio
SX3_k127_2350104_1	744872.Spica_0249	3.016e-106	350.0	COG0204@1|root,COG0204@2|Bacteria,2JA1M@203691|Spirochaetes	203691|Spirochaetes	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
SX3_k127_2350104_2	1094508.Tsac_0458	1.155e-35	145.0	COG0204@1|root,COG0204@2|Bacteria,1V5X9@1239|Firmicutes,24X01@186801|Clostridia	186801|Clostridia	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2412268_2	1123274.KB899417_gene2086	1.199e-64	244.0	COG2197@1|root,COG2197@2|Bacteria,2JA92@203691|Spirochaetes	203691|Spirochaetes	K	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
SX3_k127_2412268_0	158190.SpiGrapes_0238	2.437e-186	612.0	COG1609@1|root,COG4585@1|root,COG1609@2|Bacteria,COG4585@2|Bacteria,2J7X5@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,Peripla_BP_3
SX3_k127_2412268_1	1408473.JHXO01000008_gene2655	1.521e-126	421.0	COG0330@1|root,COG0330@2|Bacteria,4NH8V@976|Bacteroidetes,2FQPC@200643|Bacteroidia	976|Bacteroidetes	O	SPFH Band 7 PHB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
SX3_k127_2459617_13	1244869.H261_22663	0.0005311	42.0	COG3677@1|root,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria	1224|Proteobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
SX3_k127_2459617_8	1082933.MEA186_04361	8.39e-53	194.0	COG1653@1|root,COG1653@2|Bacteria,1N8AS@1224|Proteobacteria,2U19M@28211|Alphaproteobacteria,43P25@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
SX3_k127_2459617_0	313628.LNTAR_12071	6.463e-179	568.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
SX3_k127_2459617_9	426117.M446_5647	3.568e-21	98.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TVYU@28211|Alphaproteobacteria,1JXDZ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
SX3_k127_2459617_10	1123274.KB899431_gene3241	4.499e-12	72.0	2AU0F@1|root,31JKB@2|Bacteria	2|Bacteria	S	COG NOG14600 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2459617_2	357808.RoseRS_3378	2.333e-89	314.0	COG0515@1|root,COG1594@1|root,COG1716@1|root,COG0515@2|Bacteria,COG1594@2|Bacteria,COG1716@2|Bacteria,2G7ZS@200795|Chloroflexi,3757W@32061|Chloroflexia	200795|Chloroflexi	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
SX3_k127_2459617_6	880072.Desac_2942	3.094e-59	216.0	COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,42QUA@68525|delta/epsilon subdivisions,2WP2A@28221|Deltaproteobacteria,2MRZW@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	PFAM Protein phosphatase 2C	-	-	3.1.3.16	ko:K01090,ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
SX3_k127_2459617_3	1379698.RBG1_1C00001G0608	3.186e-76	283.0	COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K08282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,TPR_16,TPR_2,TPR_8,TolB_N
SX3_k127_2459617_4	1303518.CCALI_00292	1.124e-65	240.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	DUF5128,NHL,VPEP
SX3_k127_2459617_7	485913.Krac_2635	2.252e-54	209.0	COG0457@1|root,COG3629@1|root,COG3899@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG3899@2|Bacteria,2G871@200795|Chloroflexi	200795|Chloroflexi	K	Transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,TPR_12
SX3_k127_2459617_12	1038859.AXAU01000005_gene5141	1.189e-06	61.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,3JR8W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_8
SX3_k127_2459617_1	1379698.RBG1_1C00001G0607	1.772e-141	479.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,TPR_2,TPR_8
SX3_k127_2459617_14	1048983.EL17_06890	0.0005459	51.0	COG3637@1|root,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl,OMP_b-brl_2
SX3_k127_2459617_5	264198.Reut_C6415	3.772e-62	223.0	COG3464@1|root,COG3464@2|Bacteria,1N2V1@1224|Proteobacteria,2WESJ@28216|Betaproteobacteria,1KHUQ@119060|Burkholderiaceae	28216|Betaproteobacteria	L	zinc-finger of transposase IS204/IS1001/IS1096/IS1165	-	-	-	ko:K07485	-	-	-	-	ko00000	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
SX3_k127_2463712_16	665571.STHERM_c01080	7.971e-10	71.0	2BFD2@1|root,3296F@2|Bacteria,2JB82@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2463712_5	1307761.L21SP2_1267	8.955e-83	300.0	2F00C@1|root,33T4C@2|Bacteria,2J5MS@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2463712_7	1047013.AQSP01000008_gene2209	7.913e-76	281.0	COG2220@1|root,COG2220@2|Bacteria,2NQD1@2323|unclassified Bacteria	2|Bacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
SX3_k127_2463712_1	521045.Kole_0146	1.639e-127	420.0	COG1168@1|root,COG1168@2|Bacteria,2GCM9@200918|Thermotogae	200918|Thermotogae	E	aminotransferase class I and II	-	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Acetyltransf_10,Aminotran_1_2
SX3_k127_2463712_17	448385.sce0535	4.303e-08	65.0	2EJ2M@1|root,33CTU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2463712_10	688269.Theth_1089	5.661e-55	205.0	COG1172@1|root,COG1172@2|Bacteria	2|Bacteria	G	Belongs to the binding-protein-dependent transport system permease family	iolTB	-	-	ko:K02057,ko:K03466	-	M00221	-	-	ko00000,ko00002,ko02000,ko03036	3.A.1.2,3.A.12	-	-	BPD_transp_2
SX3_k127_2463712_9	290400.Jann_1427	2.517e-59	215.0	COG1129@1|root,COG1129@2|Bacteria,1MW4I@1224|Proteobacteria,2TY4S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	abc transporter atp-binding protein	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
SX3_k127_2463712_11	309803.CTN_0239	1.435e-54	205.0	COG1172@1|root,COG1172@2|Bacteria,2GE4I@200918|Thermotogae	200918|Thermotogae	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057,ko:K10440	ko02010,map02010	M00212,M00221	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
SX3_k127_2463712_13	309803.CTN_0240	8.909e-32	137.0	COG1879@1|root,COG1879@2|Bacteria	2|Bacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K02058,ko:K10439	ko02010,ko02030,map02010,map02030	M00212,M00221	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
SX3_k127_2463712_2	180332.JTGN01000004_gene2365	1.765e-122	406.0	28MXM@1|root,2ZB4M@2|Bacteria,1UYF1@1239|Firmicutes,24DFA@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2463712_4	556261.HMPREF0240_01653	1.519e-110	370.0	COG0407@1|root,COG0407@2|Bacteria,1V4WM@1239|Firmicutes,24YPF@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_2463712_3	309799.DICTH_0141	1.361e-114	386.0	COG2379@1|root,COG2379@2|Bacteria	2|Bacteria	G	hydroxypyruvate reductase	ttuD	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
SX3_k127_2463712_12	596151.DesfrDRAFT_0921	8.637e-35	151.0	COG1116@1|root,COG1116@2|Bacteria,1R6WT@1224|Proteobacteria,42Q8K@68525|delta/epsilon subdivisions,2X9WQ@28221|Deltaproteobacteria,2MC1H@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM ABC transporter related	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
SX3_k127_2463712_15	1122963.AUHB01000004_gene3010	3.329e-11	74.0	COG0715@1|root,COG0715@2|Bacteria,1N19G@1224|Proteobacteria,2TTZA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
SX3_k127_2463712_6	1304880.JAGB01000002_gene1777	3.961e-76	267.0	COG0673@1|root,COG0673@2|Bacteria,1TT9N@1239|Firmicutes,24EGX@186801|Clostridia	186801|Clostridia	S	Oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX3_k127_2463712_8	158190.SpiGrapes_0227	3.834e-63	225.0	COG4676@1|root,COG4676@2|Bacteria	2|Bacteria	UW	Protein conserved in bacteria	-	-	-	ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	CarboxypepD_reg,TPR_11,TPR_12,TPR_2,TPR_7,TPR_8
SX3_k127_2463712_14	96561.Dole_2867	4.309e-24	113.0	2EJPK@1|root,33DEE@2|Bacteria,1NF1Y@1224|Proteobacteria,42VT1@68525|delta/epsilon subdivisions,2WS2W@28221|Deltaproteobacteria,2MPD5@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2463712_0	665571.STHERM_c17830	2.454e-158	505.0	COG2509@1|root,COG2509@2|Bacteria,2J6ED@203691|Spirochaetes	203691|Spirochaetes	S	Oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	Pyr_redox_2
SX3_k127_2479555_5	556261.HMPREF0240_04482	1.412e-10	63.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,36DME@31979|Clostridiaceae	186801|Clostridia	P	import. Responsible for energy coupling to the transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
SX3_k127_2479555_1	1232453.BAIF02000004_gene1564	2.738e-71	256.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,24XJ7@186801|Clostridia	186801|Clostridia	G	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
SX3_k127_2479555_2	1232453.BAIF02000004_gene1563	8.041e-50	191.0	COG1172@1|root,COG1172@2|Bacteria,1UVWS@1239|Firmicutes,24Y3D@186801|Clostridia	186801|Clostridia	G	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
SX3_k127_2479555_0	556261.HMPREF0240_04485	1.267e-71	258.0	COG1879@1|root,COG1879@2|Bacteria,1US0E@1239|Firmicutes,24Y71@186801|Clostridia	186801|Clostridia	G	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_4
SX3_k127_2479555_3	1499967.BAYZ01000111_gene2953	9.043e-45	167.0	COG3254@1|root,COG3254@2|Bacteria,2NRFN@2323|unclassified Bacteria	2|Bacteria	S	L-rhamnose mutarotase	-	-	5.1.3.32	ko:K03534	-	-	R10819	RC00563	ko00000,ko01000	-	-	-	rhaM
SX3_k127_2479555_4	768710.DesyoDRAFT_5285	1.173e-43	173.0	COG0407@1|root,COG0407@2|Bacteria,1UZD2@1239|Firmicutes,24C43@186801|Clostridia,26302@186807|Peptococcaceae	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_2526_5	1380391.JIAS01000004_gene2974	2.045e-08	55.0	COG0395@1|root,COG0395@2|Bacteria,1QHIK@1224|Proteobacteria,2U2IY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type sugar transport system, permease component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX3_k127_2526_1	589865.DaAHT2_2487	2.205e-88	310.0	COG5598@1|root,COG5598@2|Bacteria,1MWJN@1224|Proteobacteria,42Q8R@68525|delta/epsilon subdivisions,2WMDK@28221|Deltaproteobacteria,2MJEG@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Trimethylamine methyltransferase	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
SX3_k127_2526_3	515635.Dtur_0062	1.253e-60	223.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
SX3_k127_2526_0	1121468.AUBR01000060_gene996	6.494e-96	321.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia,42FFS@68295|Thermoanaerobacterales	186801|Clostridia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990,ko:K11050	ko02010,map02010	M00254,M00298	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.130	-	-	ABC_tran,DUF4162
SX3_k127_2526_2	479434.Sthe_0975	2.379e-65	235.0	COG1173@1|root,COG1173@2|Bacteria,2G6HB@200795|Chloroflexi	200795|Chloroflexi	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
SX3_k127_2526_4	1480694.DC28_07175	2.629e-48	177.0	COG0747@1|root,COG0747@2|Bacteria,2J86R@203691|Spirochaetes	203691|Spirochaetes	E	Extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
SX3_k127_2533095_1	889378.Spiaf_0088	7.365e-236	747.0	COG0046@1|root,COG0046@2|Bacteria,2J66J@203691|Spirochaetes	203691|Spirochaetes	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
SX3_k127_2533095_55	889378.Spiaf_0089	3.174e-76	287.0	COG0047@1|root,COG0047@2|Bacteria,2J8JD@203691|Spirochaetes	203691|Spirochaetes	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	-	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
SX3_k127_2533095_14	1123274.KB899407_gene180	4.537e-167	541.0	COG0664@1|root,COG0664@2|Bacteria,2J6CX@203691|Spirochaetes	203691|Spirochaetes	T	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2533095_19	861299.J421_6202	3.582e-144	465.0	COG1064@1|root,COG1064@2|Bacteria,1ZSXS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Zinc-binding dehydrogenase	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
SX3_k127_2533095_44	545694.TREPR_2780	4.358e-92	329.0	COG0457@1|root,COG1652@1|root,COG0457@2|Bacteria,COG1652@2|Bacteria,2J7YH@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2533095_110	886293.Sinac_4765	6.208e-15	87.0	COG3210@1|root,COG4733@1|root,COG3210@2|Bacteria,COG4733@2|Bacteria,2J50K@203682|Planctomycetes	203682|Planctomycetes	U	Pkd domain containing protein	-	-	2.7.11.1	ko:K12567	ko05410,ko05414,map05410,map05414	-	-	-	ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812	-	-	-	-
SX3_k127_2533095_94	1499967.BAYZ01000170_gene5527	3.109e-33	143.0	COG1262@1|root,COG5635@1|root,COG1262@2|Bacteria,COG5635@2|Bacteria,2NR8B@2323|unclassified Bacteria	2|Bacteria	T	NACHT domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DUF4062,FGE-sulfatase,NACHT,TIR_2,TPR_12
SX3_k127_2533095_69	517417.Cpar_0066	1.908e-58	207.0	COG0778@1|root,COG0778@2|Bacteria,1FEBI@1090|Chlorobi	1090|Chlorobi	C	PFAM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SX3_k127_2533095_75	1125699.HMPREF9194_00274	1.794e-49	181.0	COG0597@1|root,COG0597@2|Bacteria,2J7QV@203691|Spirochaetes	203691|Spirochaetes	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
SX3_k127_2533095_51	1480694.DC28_09940	2.803e-81	278.0	COG0327@1|root,COG0327@2|Bacteria,2J6QQ@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM dinuclear metal center protein, YbgI SA1388 family	-	-	-	-	-	-	-	-	-	-	-	-	NIF3
SX3_k127_2533095_25	1480694.DC28_04730	2.757e-134	451.0	COG2211@1|root,COG2211@2|Bacteria,2J6P4@203691|Spirochaetes	203691|Spirochaetes	G	transporter	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SX3_k127_2533095_35	1480694.DC28_04735	1.06e-109	366.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2533095_43	880073.Calab_1405	1.043e-92	317.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
SX3_k127_2533095_12	642492.Clole_1307	1.203e-171	549.0	COG1032@1|root,COG1032@2|Bacteria,1UYAF@1239|Firmicutes,24D1D@186801|Clostridia	186801|Clostridia	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
SX3_k127_2533095_92	1177181.T9A_01467	8.054e-35	150.0	2BZ6D@1|root,2ZC6J@2|Bacteria,1RBC8@1224|Proteobacteria,1S3G8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2533095_56	1226325.HMPREF1548_06752	4.746e-75	266.0	COG0814@1|root,COG0814@2|Bacteria,1UTY5@1239|Firmicutes,24BAJ@186801|Clostridia,36SUU@31979|Clostridiaceae	186801|Clostridia	E	Tryptophan/tyrosine permease family	-	-	-	-	-	-	-	-	-	-	-	-	Trp_Tyr_perm
SX3_k127_2533095_117	208444.JNYY01000004_gene2035	3.68e-08	65.0	COG2197@1|root,COG2197@2|Bacteria,2HX1S@201174|Actinobacteria,4EBVW@85010|Pseudonocardiales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
SX3_k127_2533095_115	1121035.AUCH01000032_gene3452	4.117e-09	69.0	COG2931@1|root,COG2982@1|root,COG3210@1|root,COG4625@1|root,COG2931@2|Bacteria,COG2982@2|Bacteria,COG3210@2|Bacteria,COG4625@2|Bacteria,1MU7T@1224|Proteobacteria,2VTFV@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347,HemolysinCabind
SX3_k127_2533095_46	545694.TREPR_2780	5.063e-87	314.0	COG0457@1|root,COG1652@1|root,COG0457@2|Bacteria,COG1652@2|Bacteria,2J7YH@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2533095_10	697281.Mahau_1317	1.501e-175	557.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,42FF9@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SX3_k127_2533095_48	1047013.AQSP01000105_gene1454	1.232e-85	304.0	COG2086@1|root,COG2086@2|Bacteria,2NP4J@2323|unclassified Bacteria	2|Bacteria	C	Electron transfer flavoprotein	etfB	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016020,GO:0016491,GO:0022900,GO:0030312,GO:0040007,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
SX3_k127_2533095_30	459349.CLOAM1482	3.666e-127	418.0	COG2025@1|root,COG2025@2|Bacteria,2NNR6@2323|unclassified Bacteria	2|Bacteria	C	Electron transfer flavoprotein	fixB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575	1.3.1.108	ko:K03522,ko:K22432	-	-	-	-	ko00000,ko01000,ko04147	-	-	iAF987.Gmet_2066,iAF987.Gmet_2257	ETF,ETF_alpha,Fer4
SX3_k127_2533095_49	545694.TREPR_2780	1.365e-83	303.0	COG0457@1|root,COG1652@1|root,COG0457@2|Bacteria,COG1652@2|Bacteria,2J7YH@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2533095_76	338966.Ppro_2157	1.803e-48	199.0	COG4932@1|root,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria,42RZP@68525|delta/epsilon subdivisions,2X7KQ@28221|Deltaproteobacteria,43SHG@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2533095_86	1266925.JHVX01000002_gene936	8.47e-38	163.0	COG1404@1|root,COG1404@2|Bacteria,1R2W1@1224|Proteobacteria	1224|Proteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
SX3_k127_2533095_101	1223523.H340_23758	1.614e-26	114.0	2FG67@1|root,3482N@2|Bacteria,2GV16@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2533095_37	43759.JNWK01000009_gene4881	1.409e-107	359.0	COG2304@1|root,COG2304@2|Bacteria,2GKPD@201174|Actinobacteria	201174|Actinobacteria	E	IgA Peptidase M64	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M64
SX3_k127_2533095_113	380358.XALC_1350	2.205e-09	62.0	COG2002@1|root,COG2002@2|Bacteria,1NX4F@1224|Proteobacteria,1T6S4@1236|Gammaproteobacteria,1X81G@135614|Xanthomonadales	135614|Xanthomonadales	K	SpoVT / AbrB like domain	VL23_17280	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
SX3_k127_2533095_103	471853.Bcav_2739	2.371e-23	107.0	COG1487@1|root,COG1487@2|Bacteria,2INNM@201174|Actinobacteria	201174|Actinobacteria	S	ribonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	PIN
SX3_k127_2533095_88	1123274.KB899409_gene539	1.49e-37	152.0	COG1652@1|root,COG1652@2|Bacteria,2J7QX@203691|Spirochaetes	203691|Spirochaetes	S	Treponemal membrane protein	tmpB	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	LysM
SX3_k127_2533095_33	649638.Trad_2192	3.328e-114	374.0	COG1028@1|root,COG1028@2|Bacteria,1WJHI@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	IQ	COGs COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase)	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SX3_k127_2533095_40	1499967.BAYZ01000109_gene2969	8.822e-95	322.0	COG1879@1|root,COG1879@2|Bacteria	2|Bacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
SX3_k127_2533095_67	1123274.KB899416_gene2623	1.497e-58	219.0	COG1940@1|root,COG1940@2|Bacteria	2|Bacteria	GK	ROK family	nagC	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141	-	ko:K02565,ko:K15545	-	-	-	-	ko00000,ko03000	-	-	-	HTH_24,MarR,ROK
SX3_k127_2533095_36	1499967.BAYZ01000109_gene2970	8.899e-108	361.0	COG1172@1|root,COG1172@2|Bacteria	2|Bacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
SX3_k127_2533095_11	1499967.BAYZ01000109_gene2971	7.334e-174	559.0	COG1129@1|root,COG1129@2|Bacteria,2NPR8@2323|unclassified Bacteria	2|Bacteria	G	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
SX3_k127_2533095_50	1499967.BAYZ01000109_gene2972	2.747e-82	291.0	COG1172@1|root,COG1172@2|Bacteria	2|Bacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
SX3_k127_2533095_22	935948.KE386494_gene530	9.683e-137	442.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,24ATV@186801|Clostridia,42FSG@68295|Thermoanaerobacterales	186801|Clostridia	C	Alcohol dehydrogenase zinc-binding domain protein	-	-	1.1.1.14,1.1.1.303,1.1.1.4	ko:K00004,ko:K00008	ko00040,ko00051,ko00650,ko01100,map00040,map00051,map00650,map01100	M00014	R00875,R01896,R02855,R02946,R10504	RC00085,RC00102,RC00205,RC00525	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
SX3_k127_2533095_20	1499967.BAYZ01000076_gene775	2.295e-141	457.0	COG1172@1|root,COG1172@2|Bacteria,2NPUE@2323|unclassified Bacteria	2|Bacteria	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
SX3_k127_2533095_28	1122207.MUS1_01990	1.432e-129	439.0	COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,1RMCH@1236|Gammaproteobacteria,1XHFT@135619|Oceanospirillales	135619|Oceanospirillales	G	import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10441,ko:K17215	ko02010,map02010	M00212,M00593	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
SX3_k127_2533095_57	1499967.BAYZ01000076_gene773	5.073e-75	268.0	28N4R@1|root,2ZBA5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
SX3_k127_2533095_23	1499967.BAYZ01000076_gene772	4.438e-136	444.0	COG1879@1|root,COG1879@2|Bacteria	2|Bacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
SX3_k127_2533095_4	1499967.BAYZ01000176_gene5682	3.95e-201	650.0	COG1129@1|root,COG3852@1|root,COG1129@2|Bacteria,COG3852@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.7.13.3,3.6.3.17	ko:K02056,ko:K07710,ko:K17763	ko02020,map02020	M00221,M00500	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02022,ko03021	3.A.1.2	-	-	ABC_tran,GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,STAS,Spore_YpjB
SX3_k127_2533095_26	665571.STHERM_c03230	1.253e-133	441.0	COG2204@1|root,COG2204@2|Bacteria,2J5NY@203691|Spirochaetes	203691|Spirochaetes	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
SX3_k127_2533095_24	573413.Spirs_1413	6.647e-135	446.0	COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,2J5CJ@203691|Spirochaetes	203691|Spirochaetes	E	Amino-acid N-acetyltransferase	argA	-	2.3.1.1	ko:K14682	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,Acetyltransf_1
SX3_k127_2533095_102	1125863.JAFN01000001_gene436	1.893e-26	123.0	COG0644@1|root,COG0644@2|Bacteria,1MVU6@1224|Proteobacteria,42PTE@68525|delta/epsilon subdivisions,2WK6W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	HI0933-like protein	-	-	-	ko:K00313	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_3,Pyr_redox_2
SX3_k127_2533095_114	526222.Desal_1332	2.534e-09	63.0	COG1145@1|root,COG4624@1|root,COG1145@2|Bacteria,COG4624@2|Bacteria,1MUM1@1224|Proteobacteria,42PI4@68525|delta/epsilon subdivisions,2WJ5A@28221|Deltaproteobacteria,2M7QX@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	hydrogenase large subunit	-	-	1.12.7.2	ko:K00533	-	-	R00019	-	ko00000,ko01000	-	-	-	Fe_hyd_lg_C,Fer4,Fer4_6
SX3_k127_2533095_122	1463821.JOGR01000010_gene3874	7.233e-05	49.0	COG3255@1|root,COG3255@2|Bacteria,2IM6I@201174|Actinobacteria,4F04M@85014|Glycomycetales	201174|Actinobacteria	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
SX3_k127_2533095_89	1144343.PMI41_03169	3.485e-37	144.0	COG1848@1|root,COG1848@2|Bacteria,1MZR2@1224|Proteobacteria,2USTA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
SX3_k127_2533095_116	292564.Cyagr_1989	5.052e-09	59.0	2DPH3@1|root,33224@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2533095_118	272568.GDI2709	2.415e-07	58.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2U4DT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
SX3_k127_2533095_120	290315.Clim_1571	3.562e-06	53.0	COG3666@1|root,COG3666@2|Bacteria	2|Bacteria	-	-	tnp15	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
SX3_k127_2533095_85	1499967.BAYZ01000156_gene549	3.176e-38	149.0	COG1418@1|root,COG1418@2|Bacteria	2|Bacteria	S	mRNA catabolic process	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
SX3_k127_2533095_99	861299.J421_1974	2.491e-27	127.0	COG3595@1|root,COG4219@1|root,COG3595@2|Bacteria,COG4219@2|Bacteria	2|Bacteria	-	-	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	DUF4097
SX3_k127_2533095_98	886293.Sinac_6279	2.472e-27	115.0	COG3682@1|root,COG3682@2|Bacteria,2J0QT@203682|Planctomycetes	203682|Planctomycetes	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
SX3_k127_2533095_32	204669.Acid345_3014	7.183e-124	434.0	COG0784@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,3Y64H@57723|Acidobacteria,2JM5F@204432|Acidobacteriia	204432|Acidobacteriia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
SX3_k127_2533095_41	1499967.BAYZ01000097_gene4328	1.407e-94	319.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	ydeD	-	-	-	-	-	-	-	-	-	-	-	EamA
SX3_k127_2533095_123	1280668.ATVT01000002_gene3080	0.0009594	44.0	COG2159@1|root,COG2159@2|Bacteria,1TRU0@1239|Firmicutes,248VZ@186801|Clostridia,4BY14@830|Butyrivibrio	186801|Clostridia	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
SX3_k127_2533095_106	933262.AXAM01000001_gene442	2.238e-18	87.0	COG2119@1|root,COG2119@2|Bacteria,1PP1W@1224|Proteobacteria,42XF8@68525|delta/epsilon subdivisions,2WTC8@28221|Deltaproteobacteria,2MNT5@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
SX3_k127_2533095_6	1123274.KB899407_gene185	1.018e-194	619.0	COG1639@1|root,COG1639@2|Bacteria,2J5NU@203691|Spirochaetes	203691|Spirochaetes	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
SX3_k127_2533095_97	1480694.DC28_09925	6.968e-31	123.0	COG0695@1|root,COG0695@2|Bacteria,2JAZC@203691|Spirochaetes	203691|Spirochaetes	O	Glutathione S-transferase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
SX3_k127_2533095_90	545694.TREPR_2171	2.463e-36	141.0	COG2337@1|root,COG2337@2|Bacteria	2|Bacteria	T	Toxic component of a toxin-antitoxin (TA) module	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
SX3_k127_2533095_72	545695.TREAZ_2325	1.482e-55	204.0	COG0566@1|root,COG0566@2|Bacteria,2J6AD@203691|Spirochaetes	203691|Spirochaetes	J	RNA methyltransferase TrmH family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase
SX3_k127_2533095_53	744872.Spica_0014	1.586e-79	280.0	COG1454@1|root,COG1454@2|Bacteria,2J5ZT@203691|Spirochaetes	203691|Spirochaetes	C	alcohol dehydrogenase	eutG	-	1.1.1.1	ko:K13954,ko:K19954	ko00010,ko00071,ko00350,ko00625,ko00626,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R04880,R05233,R05234,R06917,R06927	RC00050,RC00088,RC00099,RC00116,RC00649	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
SX3_k127_2533095_105	1480694.DC28_09905	2.14e-18	87.0	2DFDU@1|root,2ZRHI@2|Bacteria,2J8SZ@203691|Spirochaetes	203691|Spirochaetes	S	factor, FlgM	-	-	-	ko:K02398	ko02020,ko02025,ko02026,ko02040,map02020,map02025,map02026,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgM
SX3_k127_2533095_91	192952.MM_0752	4.09e-36	142.0	COG0622@1|root,arCOG01141@2157|Archaea,2XX8V@28890|Euryarchaeota,2NB0G@224756|Methanomicrobia	224756|Methanomicrobia	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
SX3_k127_2533095_77	1307761.L21SP2_2213	1.071e-47	188.0	COG0345@1|root,COG0345@2|Bacteria,2J6DB@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
SX3_k127_2533095_52	1123257.AUFV01000010_gene3349	3.407e-80	298.0	COG3292@1|root,COG3386@1|root,COG3292@2|Bacteria,COG3386@2|Bacteria,1N3BV@1224|Proteobacteria	1224|Proteobacteria	G	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1
SX3_k127_2533095_47	545694.TREPR_2780	8.387e-86	311.0	COG0457@1|root,COG1652@1|root,COG0457@2|Bacteria,COG1652@2|Bacteria,2J7YH@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2533095_79	419947.MRA_1849	1.534e-46	174.0	COG1848@1|root,COG1848@2|Bacteria	2|Bacteria	G	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	GO:0005575,GO:0005576	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
SX3_k127_2533095_107	419947.MRA_1850	2.672e-18	87.0	2BE1Z@1|root,327SM@2|Bacteria,2HDGJ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2533095_8	573413.Spirs_2904	1.229e-180	575.0	COG0172@1|root,COG0172@2|Bacteria,2J5EM@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
SX3_k127_2533095_54	665571.STHERM_c00550	2.68e-77	273.0	COG2844@1|root,COG2844@2|Bacteria,2J5W2@203691|Spirochaetes	203691|Spirochaetes	O	HD domain	-	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	HD
SX3_k127_2533095_80	1122138.AQUZ01000012_gene6041	1.556e-46	190.0	2C1EG@1|root,2Z7MZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2533095_18	665571.STHERM_c00540	1.694e-144	502.0	COG0498@1|root,COG0498@2|Bacteria,2J63T@203691|Spirochaetes	203691|Spirochaetes	E	Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
SX3_k127_2533095_38	269798.CHU_0074	1.224e-105	351.0	COG0083@1|root,COG0083@2|Bacteria,4NE2M@976|Bacteroidetes,47KGY@768503|Cytophagia	976|Bacteroidetes	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	-	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
SX3_k127_2533095_17	665571.STHERM_c00530	9.176e-155	508.0	COG0527@1|root,COG0527@2|Bacteria,2J5C6@203691|Spirochaetes	203691|Spirochaetes	E	Amino acid kinase family	-	-	1.1.1.3,2.7.2.4	ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3
SX3_k127_2533095_63	1499967.BAYZ01000009_gene5346	8.757e-66	228.0	COG0432@1|root,COG0432@2|Bacteria,2NPB7@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
SX3_k127_2533095_71	880072.Desac_1954	1.302e-55	205.0	COG1560@1|root,COG1560@2|Bacteria	2|Bacteria	M	Kdo2-lipid A biosynthetic process	waaM	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
SX3_k127_2533095_65	1125863.JAFN01000001_gene72	5.921e-60	230.0	COG2206@1|root,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,42MEJ@68525|delta/epsilon subdivisions,2X71A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	metal-dependent phosphohydrolase HD region	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HAMP,HD,HD_5
SX3_k127_2533095_84	32057.KB217478_gene1667	3.589e-39	160.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
SX3_k127_2533095_61	573370.DMR_03030	3.991e-67	250.0	COG1032@1|root,COG1032@2|Bacteria,1RECP@1224|Proteobacteria,42ZSY@68525|delta/epsilon subdivisions,2WV3E@28221|Deltaproteobacteria,2M7UT@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
SX3_k127_2533095_74	906968.Trebr_0724	8.989e-51	198.0	COG0293@1|root,COG0293@2|Bacteria,2J5SK@203691|Spirochaetes	203691|Spirochaetes	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	ftsJ	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
SX3_k127_2533095_70	545694.TREPR_0455	2.378e-57	214.0	COG0705@1|root,COG0705@2|Bacteria,2J7HV@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
SX3_k127_2533095_93	889378.Spiaf_0084	7.02e-34	146.0	2FBC5@1|root,343I0@2|Bacteria,2J6WZ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2533095_21	573413.Spirs_4114	1.391e-138	458.0	COG4166@1|root,COG4166@2|Bacteria,2J5KU@203691|Spirochaetes	203691|Spirochaetes	E	Bacterial extracellular solute-binding proteins, family 5	-	-	-	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
SX3_k127_2533095_16	416591.Tlet_1499	7.086e-156	503.0	COG0426@1|root,COG0426@2|Bacteria,2GCAS@200918|Thermotogae	200918|Thermotogae	C	flavodoxin nitric oxide synthase	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Lactamase_B
SX3_k127_2533095_82	665571.STHERM_c18960	2.485e-44	173.0	COG0398@1|root,COG0398@2|Bacteria,2J8MX@203691|Spirochaetes	203691|Spirochaetes	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
SX3_k127_2533095_59	545694.TREPR_1023	1.852e-70	243.0	COG1329@1|root,COG1329@2|Bacteria,2J7TP@203691|Spirochaetes	203691|Spirochaetes	K	Transcription factor	-	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
SX3_k127_2533095_83	573413.Spirs_4117	5.568e-43	179.0	COG1211@1|root,COG1211@2|Bacteria,2J6JT@203691|Spirochaetes	203691|Spirochaetes	I	Belongs to the IspD TarI cytidylyltransferase family. IspD subfamily	ispD	-	2.7.7.60,4.6.1.12	ko:K00991,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
SX3_k127_2533095_78	596320.NEIFL0001_0928	1.989e-47	175.0	COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,2VR7F@28216|Betaproteobacteria,2KQVT@206351|Neisseriales	206351|Neisseriales	H	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
SX3_k127_2533095_64	158189.SpiBuddy_0036	1.638e-64	228.0	COG0177@1|root,COG0177@2|Bacteria,2J7HG@203691|Spirochaetes	203691|Spirochaetes	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
SX3_k127_2533095_104	1121904.ARBP01000012_gene1314	2.55e-23	112.0	COG0494@1|root,COG0494@2|Bacteria,4NSND@976|Bacteroidetes	976|Bacteroidetes	L	Belongs to the Nudix hydrolase family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
SX3_k127_2533095_111	317655.Sala_2632	1.189e-10	67.0	COG0776@1|root,COG0776@2|Bacteria,1RIJM@1224|Proteobacteria,2UAU1@28211|Alphaproteobacteria,2K5US@204457|Sphingomonadales	204457|Sphingomonadales	L	Belongs to the bacterial histone-like protein family	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
SX3_k127_2533095_95	889378.Spiaf_0087	5.734e-33	134.0	COG1762@1|root,COG1762@2|Bacteria	2|Bacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system	ptsN	-	2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2
SX3_k127_2533095_60	1123274.KB899438_gene649	3.188e-67	239.0	COG0106@1|root,COG0106@2|Bacteria,2J8GX@203691|Spirochaetes	203691|Spirochaetes	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
SX3_k127_2533095_100	436114.SYO3AOP1_0528	1.101e-26	116.0	COG0703@1|root,COG0703@2|Bacteria,2G46N@200783|Aquificae	200783|Aquificae	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
SX3_k127_2533095_39	665571.STHERM_c01020	7.738e-105	349.0	COG1210@1|root,COG1210@2|Bacteria,2J70S@203691|Spirochaetes	203691|Spirochaetes	M	Nucleotidyl transferase	gtaB	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
SX3_k127_2533095_13	1499967.BAYZ01000097_gene4341	1.772e-167	542.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
SX3_k127_2533095_62	485915.Dret_0612	3.985e-66	248.0	COG0624@1|root,COG0624@2|Bacteria	2|Bacteria	E	succinyl-diaminopimelate desuccinylase activity	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
SX3_k127_2533095_45	1499967.BAYZ01000097_gene4340	8.829e-89	302.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	ko:K02025,ko:K15771	ko02010,map02010	M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
SX3_k127_2533095_34	1499967.BAYZ01000097_gene4339	5.179e-113	371.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX3_k127_2533095_42	1123274.KB899407_gene241	5.367e-93	319.0	COG1301@1|root,COG1301@2|Bacteria,2J6P3@203691|Spirochaetes	203691|Spirochaetes	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
SX3_k127_2533095_73	987059.RBXJA2T_13839	1.744e-54	204.0	COG0640@1|root,COG0640@2|Bacteria,1R0XC@1224|Proteobacteria,2WHXS@28216|Betaproteobacteria	28216|Betaproteobacteria	K	STAS-like domain of unknown function (DUF4325)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4325
SX3_k127_2533095_7	96561.Dole_2961	1.849e-188	605.0	COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,42MK9@68525|delta/epsilon subdivisions,2WJ1C@28221|Deltaproteobacteria,2MIP5@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM PhoH-like protein	phoH1	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
SX3_k127_2533095_96	886293.Sinac_0549	5.715e-31	126.0	COG0724@1|root,COG0724@2|Bacteria,2IZPY@203682|Planctomycetes	203682|Planctomycetes	S	PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
SX3_k127_2533095_0	706587.Desti_5357	3.603e-238	745.0	COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,42MVJ@68525|delta/epsilon subdivisions,2WKM4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	methylmalonate-semialdehyde dehydrogenase	mmsA	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
SX3_k127_2533095_121	633148.Tagg_0945	7.772e-06	53.0	COG1953@1|root,arCOG03448@2157|Archaea,2XRAY@28889|Crenarchaeota	28889|Crenarchaeota	F	Permease for cytosine/purines, uracil, thiamine, allantoin	-	-	-	ko:K03457	-	-	-	-	ko00000	2.A.39	-	-	Transp_cyt_pur
SX3_k127_2533095_68	401526.TcarDRAFT_0774	1.68e-58	209.0	COG4636@1|root,COG4636@2|Bacteria,1V4N9@1239|Firmicutes,4H5XT@909932|Negativicutes	909932|Negativicutes	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
SX3_k127_2533095_31	485918.Cpin_3446	3.697e-126	409.0	COG0388@1|root,COG0388@2|Bacteria,4NEME@976|Bacteroidetes,1IV6M@117747|Sphingobacteriia	976|Bacteroidetes	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.53,3.5.1.6	ko:K01431,ko:K12251	ko00240,ko00330,ko00410,ko00770,ko00983,ko01100,map00240,map00330,map00410,map00770,map00983,map01100	M00046	R00905,R01152,R04666,R08228	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase
SX3_k127_2533095_15	1121918.ARWE01000001_gene380	1.82e-160	518.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WJHC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM glutamate synthase (NADPH), homotetrameric	-	-	1.3.1.1	ko:K17722	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046	R00977,R01414,R11026	RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_20,Pyr_redox_2
SX3_k127_2533095_3	1121918.ARWE01000001_gene381	3.459e-207	651.0	COG0167@1|root,COG1146@1|root,COG0167@2|Bacteria,COG1146@2|Bacteria,1MXER@1224|Proteobacteria,42YD3@68525|delta/epsilon subdivisions,2WTVV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Dihydroorotate dehydrogenase	yeiA	-	1.3.1.1	ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046	R00977,R01414,R11026	RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh,Fer4_21
SX3_k127_2533095_5	1121918.ARWE01000001_gene382	5.391e-198	641.0	COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,42PXH@68525|delta/epsilon subdivisions,2WKEX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Amidohydrolase family	-	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
SX3_k127_2533095_29	1218076.BAYB01000030_gene4889	6.94e-128	421.0	COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,2VHQ8@28216|Betaproteobacteria,1K0H7@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Amidase, hydantoinase carbamoylase family	-	-	3.5.1.6,3.5.1.87	ko:K06016	ko00240,ko01100,map00240,map01100	M00046	R00905,R04666	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
SX3_k127_2533095_27	1449050.JNLE01000003_gene2651	4.082e-132	437.0	COG0161@1|root,COG0161@2|Bacteria,1TP9N@1239|Firmicutes,25E7B@186801|Clostridia,36GAX@31979|Clostridiaceae	186801|Clostridia	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	bioA	-	2.6.1.113,2.6.1.55,2.6.1.62,2.6.1.77	ko:K00833,ko:K03851,ko:K12256,ko:K15372	ko00330,ko00410,ko00430,ko00780,ko01100,map00330,map00410,map00430,map00780,map01100	M00123,M00573,M00577	R00908,R01684,R03231,R05652,R08714	RC00006,RC00008,RC00062,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SX3_k127_2533095_9	1304885.AUEY01000007_gene1357	1.369e-175	595.0	COG2202@1|root,COG2905@1|root,COG4564@1|root,COG2202@2|Bacteria,COG2905@2|Bacteria,COG4564@2|Bacteria,1MW8U@1224|Proteobacteria,42NAX@68525|delta/epsilon subdivisions,2WJF5@28221|Deltaproteobacteria,2MIA9@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Putative nucleotidyltransferase substrate binding domain	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,PAS_8,cNMP_binding,sCache_2
SX3_k127_2533095_108	948106.AWZT01000007_gene3575	2.377e-17	98.0	COG0613@1|root,COG0613@2|Bacteria,1MWIH@1224|Proteobacteria,2VHB2@28216|Betaproteobacteria,1K1H7@119060|Burkholderiaceae	28216|Betaproteobacteria	S	SMART phosphoesterase PHP domain protein	-	GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0097657	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
SX3_k127_2533095_109	1121396.KB893012_gene4099	1.062e-15	82.0	COG3162@1|root,COG3162@2|Bacteria,1NB5T@1224|Proteobacteria,42VP8@68525|delta/epsilon subdivisions,2WSCP@28221|Deltaproteobacteria,2MNWK@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function, DUF485	-	-	-	-	-	-	-	-	-	-	-	-	DUF485
SX3_k127_2533095_2	1232410.KI421416_gene2649	6.632e-227	719.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,42MJE@68525|delta/epsilon subdivisions,2WK5T@28221|Deltaproteobacteria,43TCV@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	aplA	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	iAF987.Gmet_0739	SSF
SX3_k127_2533095_58	926560.KE387023_gene3344	4.484e-72	257.0	2DBC8@1|root,2Z8C9@2|Bacteria,1WKX1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2533095_66	880073.Calab_1882	1.629e-59	217.0	COG1387@1|root,COG1387@2|Bacteria,2NPQX@2323|unclassified Bacteria	2|Bacteria	E	PHP domain	hisK	GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP,PHP_C
SX3_k127_2533095_87	1296416.JACB01000017_gene5141	8.932e-38	146.0	COG0500@1|root,COG2226@2|Bacteria,4PH0U@976|Bacteroidetes,1IHRF@117743|Flavobacteriia,2YIT4@290174|Aquimarina	976|Bacteroidetes	Q	Hypothetical methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
SX3_k127_2537640_8	1232410.KI421428_gene1010	3.873e-41	157.0	COG0864@1|root,COG0864@2|Bacteria,1RK4R@1224|Proteobacteria,42SID@68525|delta/epsilon subdivisions,2WQ86@28221|Deltaproteobacteria,43SGS@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	nickel-responsive regulator	nikR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
SX3_k127_2537640_9	573370.DMR_00660	5.22e-24	108.0	COG1848@1|root,COG1848@2|Bacteria,1PBM6@1224|Proteobacteria,43ECN@68525|delta/epsilon subdivisions,2X0C7@28221|Deltaproteobacteria,2MBSV@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	vapC	-	-	-	-	-	-	-	-	-	-	-	PIN
SX3_k127_2537640_11	526227.Mesil_3283	4.816e-08	58.0	COG2002@1|root,COG2002@2|Bacteria	2|Bacteria	K	toxin-antitoxin pair type II binding	-	-	-	ko:K06284	-	-	-	-	ko00000,ko03000	-	-	-	ABC_tran,MazE_antitoxin
SX3_k127_2537640_5	500635.MITSMUL_04306	1.818e-69	252.0	COG1606@1|root,COG1606@2|Bacteria,1TPB2@1239|Firmicutes,4H3JI@909932|Negativicutes	909932|Negativicutes	S	TIGR00268 family	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	ATP_bind_3,Asn_synthase,NAD_synthase
SX3_k127_2537640_4	1128421.JAGA01000002_gene1225	3.512e-74	256.0	COG1691@1|root,COG1691@2|Bacteria,2NPQT@2323|unclassified Bacteria	2|Bacteria	S	AIR carboxylase	cpmA	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
SX3_k127_2537640_0	1128421.JAGA01000002_gene622	6.302e-107	369.0	COG1641@1|root,COG1641@2|Bacteria,2NNX0@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function DUF111	larC	-	4.99.1.12	ko:K06898,ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
SX3_k127_2537640_10	471855.Shel_25910	4.78e-10	66.0	COG1476@1|root,COG2002@1|root,COG1476@2|Bacteria,COG2002@2|Bacteria,2H8HI@201174|Actinobacteria,4CW84@84998|Coriobacteriia	84998|Coriobacteriia	K	AbrB family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
SX3_k127_2537640_1	1480694.DC28_06800	2.225e-96	327.0	COG1136@1|root,COG1136@2|Bacteria,2J5PI@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_2537640_3	1307761.L21SP2_0314	1.052e-79	284.0	COG0577@1|root,COG0577@2|Bacteria,2J5MA@203691|Spirochaetes	203691|Spirochaetes	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
SX3_k127_2537640_2	1480694.DC28_06810	3.087e-87	305.0	COG4591@1|root,COG4591@2|Bacteria,2J6KF@203691|Spirochaetes	203691|Spirochaetes	M	ABC transporter permease	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX3_k127_2537640_6	1307761.L21SP2_0316	9.551e-56	205.0	COG2834@1|root,COG2834@2|Bacteria,2J5TZ@203691|Spirochaetes	203691|Spirochaetes	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
SX3_k127_2537640_7	1480694.DC28_06820	3.857e-44	179.0	2DNEA@1|root,32X2Y@2|Bacteria,2J767@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2554023_1	309798.COPRO5265_0008	3.807e-69	242.0	COG1180@1|root,COG1180@2|Bacteria,1V1GP@1239|Firmicutes,24G76@186801|Clostridia,42G5Q@68295|Thermoanaerobacterales	186801|Clostridia	O	TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
SX3_k127_2554023_0	1259795.ARJK01000004_gene1361	1.582e-180	570.0	COG1328@1|root,COG1328@2|Bacteria,1TR9K@1239|Firmicutes,247WF@186801|Clostridia,42ET1@68295|Thermoanaerobacterales	186801|Clostridia	F	TIGRFAM anaerobic ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,Glutaredoxin,NRDD
SX3_k127_257489_3	573413.Spirs_2147	2.737e-151	485.0	COG0525@1|root,COG0525@2|Bacteria,2J659@203691|Spirochaetes	203691|Spirochaetes	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
SX3_k127_257489_15	1319815.HMPREF0202_01844	4.115e-65	231.0	COG0778@1|root,COG0778@2|Bacteria,37B30@32066|Fusobacteria	32066|Fusobacteria	C	Psort location Cytoplasmic, score 8.96	-	-	1.5.1.39	ko:K19286	ko00740,ko01100,map00740,map01100	-	R05705,R05706	RC00126	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
SX3_k127_257489_17	1449347.JQLN01000004_gene7281	1.281e-53	202.0	COG0524@1|root,COG0524@2|Bacteria,2I04R@201174|Actinobacteria,2M34K@2063|Kitasatospora	201174|Actinobacteria	G	pfkB family carbohydrate kinase	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
SX3_k127_257489_29	316067.Geob_3223	0.0005894	52.0	COG3417@1|root,COG3417@2|Bacteria,1RA6V@1224|Proteobacteria,42UKY@68525|delta/epsilon subdivisions,2WR6E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Collagen-binding surface adhesin SpaP (antigen I II family)	-	-	-	ko:K07337	-	-	-	-	ko00000	-	-	-	LpoB
SX3_k127_257489_26	1283284.AZUK01000001_gene2344	8.209e-14	84.0	COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,1RNG1@1236|Gammaproteobacteria,1Y6FD@135624|Aeromonadales	135624|Aeromonadales	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
SX3_k127_257489_24	1265505.ATUG01000001_gene3978	1.33e-29	134.0	COG2203@1|root,COG2203@2|Bacteria,1NT6X@1224|Proteobacteria,42XRB@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2
SX3_k127_257489_18	665571.STHERM_c03350	2.417e-52	193.0	COG2078@1|root,COG2078@2|Bacteria,2J7B9@203691|Spirochaetes	203691|Spirochaetes	S	AMMECR1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
SX3_k127_257489_23	665571.STHERM_c03360	5.484e-30	134.0	COG1355@1|root,COG1355@2|Bacteria,2J963@203691|Spirochaetes	203691|Spirochaetes	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
SX3_k127_257489_12	926550.CLDAP_14190	5.232e-80	273.0	COG1945@1|root,COG1945@2|Bacteria	2|Bacteria	I	arginine decarboxylase activity	pdaD	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
SX3_k127_257489_2	1128421.JAGA01000004_gene2510	3.267e-152	494.0	COG1899@1|root,COG1899@2|Bacteria,2NR8I@2323|unclassified Bacteria	2|Bacteria	O	Deoxyhypusine synthase	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
SX3_k127_257489_11	926550.CLDAP_14200	1.1e-82	284.0	COG0010@1|root,COG0010@2|Bacteria,2G6IN@200795|Chloroflexi	200795|Chloroflexi	E	Arginase family	-	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
SX3_k127_257489_8	573413.Spirs_2274	2.083e-105	366.0	COG1293@1|root,COG1293@2|Bacteria,2J61Z@203691|Spirochaetes	203691|Spirochaetes	K	Fibrinogen-binding protein	FbpA	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
SX3_k127_257489_16	573413.Spirs_2273	3.408e-56	221.0	COG2110@1|root,COG2110@2|Bacteria,2J6ZA@203691|Spirochaetes	203691|Spirochaetes	S	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Macro
SX3_k127_257489_9	1123274.KB899422_gene74	1.352e-91	333.0	COG0285@1|root,COG0285@2|Bacteria,2J5CZ@203691|Spirochaetes	203691|Spirochaetes	H	TIGRFAM folylpolyglutamate synthase dihydrofolate synthase	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
SX3_k127_257489_1	665571.STHERM_c04540	1.441e-183	586.0	COG0707@1|root,COG0707@2|Bacteria,2J9T2@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_257489_5	665571.STHERM_c03400	1.533e-137	457.0	COG0141@1|root,COG0141@2|Bacteria,2J5QF@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
SX3_k127_257489_19	889378.Spiaf_2755	2.563e-50	187.0	COG0406@1|root,COG0406@2|Bacteria,2J9E6@203691|Spirochaetes	203691|Spirochaetes	G	Phosphoglycerate mutase family	-	-	3.1.3.3,3.1.3.73,5.4.2.12	ko:K02226,ko:K15634,ko:K22305	ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00122	R00582,R01518,R04594,R11173	RC00017,RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
SX3_k127_257489_6	1231241.Mc24_02338	1.773e-123	416.0	COG2723@1|root,COG2723@2|Bacteria,2GC3E@200918|Thermotogae	200918|Thermotogae	G	hydrolase, family 1	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
SX3_k127_257489_0	247490.KSU1_C1370	8.615e-244	770.0	COG0443@1|root,COG0443@2|Bacteria,2IWWS@203682|Planctomycetes	203682|Planctomycetes	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
SX3_k127_257489_7	1480694.DC28_02925	1.749e-105	351.0	COG4152@1|root,COG4152@2|Bacteria,2JBF0@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF4162)	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SX3_k127_257489_14	1480694.DC28_02930	7.281e-74	271.0	COG1668@1|root,COG1668@2|Bacteria	2|Bacteria	CP	transmembrane transport	natB	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
SX3_k127_257489_27	555079.Toce_0566	3.088e-08	60.0	COG1669@1|root,COG1669@2|Bacteria,1VHUJ@1239|Firmicutes,24RYZ@186801|Clostridia,42HC9@68295|Thermoanaerobacterales	186801|Clostridia	S	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_257489_25	592015.HMPREF1705_00491	4.198e-29	124.0	COG1669@1|root,COG1669@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
SX3_k127_257489_10	926550.CLDAP_32200	2.46e-84	307.0	COG0246@1|root,COG0246@2|Bacteria	2|Bacteria	G	mannitol metabolic process	-	-	1.1.1.17	ko:K00009	ko00051,map00051	-	R02703	RC00085	ko00000,ko00001,ko01000	-	-	-	Mannitol_dh,Mannitol_dh_C
SX3_k127_257489_28	744872.Spica_1555	6.996e-05	53.0	299Z2@1|root,2ZX0S@2|Bacteria,2JB3Q@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_257489_20	391625.PPSIR1_10500	1.7e-45	172.0	COG1595@1|root,COG1595@2|Bacteria,1RHSF@1224|Proteobacteria,438JV@68525|delta/epsilon subdivisions,2X3UH@28221|Deltaproteobacteria,2YX4W@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	HTH_24,Sigma70_r2,Sigma70_r4_2
SX3_k127_257489_21	502025.Hoch_1607	3.205e-36	153.0	COG5662@1|root,COG5662@2|Bacteria,1Q39S@1224|Proteobacteria,4390Y@68525|delta/epsilon subdivisions,2X465@28221|Deltaproteobacteria,2YYC2@29|Myxococcales	28221|Deltaproteobacteria	K	AntiSigma factor	actD	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_257489_4	502025.Hoch_1608	6.18e-147	492.0	COG4249@1|root,COG4249@2|Bacteria,1NJ33@1224|Proteobacteria,42PEW@68525|delta/epsilon subdivisions,2WRUQ@28221|Deltaproteobacteria,2Z389@29|Myxococcales	28221|Deltaproteobacteria	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,WD40
SX3_k127_257489_13	1480694.DC28_10390	5.101e-78	270.0	COG2309@1|root,COG2309@2|Bacteria,2J7AX@203691|Spirochaetes	203691|Spirochaetes	E	Aminopeptidase	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
SX3_k127_2618096_80	744872.Spica_2332	3.328e-67	242.0	COG2815@1|root,COG2815@2|Bacteria,2J5J2@203691|Spirochaetes	203691|Spirochaetes	S	Pasta domain protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA
SX3_k127_2618096_63	889378.Spiaf_1091	1.64e-85	295.0	COG0223@1|root,COG0223@2|Bacteria,2J621@203691|Spirochaetes	203691|Spirochaetes	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
SX3_k127_2618096_96	744872.Spica_2334	5.22e-51	194.0	COG0242@1|root,COG0242@2|Bacteria,2J7X0@203691|Spirochaetes	203691|Spirochaetes	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
SX3_k127_2618096_4	889378.Spiaf_1079	1.08e-220	702.0	COG1198@1|root,COG1198@2|Bacteria,2J5B4@203691|Spirochaetes	203691|Spirochaetes	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
SX3_k127_2618096_83	1123274.KB899413_gene766	7.503e-63	226.0	COG1573@1|root,COG1573@2|Bacteria,2J612@203691|Spirochaetes	203691|Spirochaetes	L	Uracil-DNA glycosylase, family 4	ung	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
SX3_k127_2618096_67	665571.STHERM_c18330	2.642e-81	283.0	COG0101@1|root,COG0101@2|Bacteria,2J65Z@203691|Spirochaetes	203691|Spirochaetes	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
SX3_k127_2618096_55	665571.STHERM_c18340	7.586e-94	316.0	COG1655@1|root,COG1655@2|Bacteria,2J5GN@203691|Spirochaetes	203691|Spirochaetes	S	protein conserved in bacteria	-	-	-	ko:K09766	-	-	-	-	ko00000	-	-	-	DUF2225
SX3_k127_2618096_109	545694.TREPR_1938	2.79e-37	145.0	COG0736@1|root,COG0736@2|Bacteria,2J8AA@203691|Spirochaetes	203691|Spirochaetes	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
SX3_k127_2618096_88	573413.Spirs_1648	5.334e-61	222.0	COG4856@1|root,COG4856@2|Bacteria,2J5XW@203691|Spirochaetes	203691|Spirochaetes	S	YbbR-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
SX3_k127_2618096_69	573413.Spirs_1647	6.215e-81	277.0	COG1624@1|root,COG1624@2|Bacteria,2J5ZB@203691|Spirochaetes	203691|Spirochaetes	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
SX3_k127_2618096_59	574087.Acear_1783	5.641e-89	308.0	COG0294@1|root,COG0294@2|Bacteria,1TPKT@1239|Firmicutes,248BE@186801|Clostridia,3WBAE@53433|Halanaerobiales	186801|Clostridia	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS03115	Pterin_bind
SX3_k127_2618096_122	573413.Spirs_2885	2.297e-20	100.0	COG2063@1|root,COG2063@2|Bacteria	2|Bacteria	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgH	GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464	-	ko:K02393	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgH
SX3_k127_2618096_138	945713.IALB_2216	1.536e-07	53.0	2EIUI@1|root,33CJV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2618096_73	906968.Trebr_1162	3.629e-79	274.0	COG0324@1|root,COG0324@2|Bacteria,2J6T2@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
SX3_k127_2618096_129	1480694.DC28_05555	3.206e-16	80.0	COG1758@1|root,COG1758@2|Bacteria	2|Bacteria	K	DNA-directed 5'-3' RNA polymerase activity	rpoZ	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
SX3_k127_2618096_100	545694.TREPR_2412	4.868e-48	178.0	COG1102@1|root,COG1102@2|Bacteria,2J5P9@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the cytidylate kinase family. Type 2 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
SX3_k127_2618096_77	1480694.DC28_14470	7.898e-75	261.0	COG1561@1|root,COG1561@2|Bacteria,2J76C@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM TIGR00255 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
SX3_k127_2618096_17	1539298.JO41_08040	5.275e-158	512.0	COG0773@1|root,COG0773@2|Bacteria,2J5DC@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
SX3_k127_2618096_104	706587.Desti_3013	1.437e-41	159.0	COG0247@1|root,COG1150@1|root,COG0247@2|Bacteria,COG1150@2|Bacteria,1MUMH@1224|Proteobacteria,42N9U@68525|delta/epsilon subdivisions,2WINY@28221|Deltaproteobacteria	1224|Proteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
SX3_k127_2618096_45	639030.JHVA01000001_gene2853	5.736e-103	356.0	COG0624@1|root,COG0624@2|Bacteria	2|Bacteria	E	succinyl-diaminopimelate desuccinylase activity	dapE2	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
SX3_k127_2618096_99	1234364.AMSF01000033_gene430	1.029e-48	180.0	COG1765@1|root,COG1765@2|Bacteria,1PHC3@1224|Proteobacteria,1TA7C@1236|Gammaproteobacteria,1X8WZ@135614|Xanthomonadales	135614|Xanthomonadales	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
SX3_k127_2618096_87	1123274.KB899409_gene425	1.943e-61	228.0	2DRY6@1|root,33DN5@2|Bacteria,2JB74@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2618096_48	573413.Spirs_1516	5.189e-101	351.0	COG0621@1|root,COG0621@2|Bacteria,2J5SB@203691|Spirochaetes	203691|Spirochaetes	J	Radical SAM methylthiotransferase, MiaB RimO family	yqeV	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
SX3_k127_2618096_95	573413.Spirs_1515	3.474e-51	194.0	COG0457@1|root,COG0457@2|Bacteria,2J7IN@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC3,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
SX3_k127_2618096_105	573413.Spirs_1514	2.987e-40	155.0	COG1664@1|root,COG1664@2|Bacteria,2J861@203691|Spirochaetes	203691|Spirochaetes	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
SX3_k127_2618096_71	665571.STHERM_c08700	1.075e-79	273.0	COG0287@1|root,COG0287@2|Bacteria	2|Bacteria	E	prephenate dehydrogenase (NADP+) activity	tyrA	-	1.3.1.12	ko:K00210	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2,PDH
SX3_k127_2618096_30	665571.STHERM_c08690	1.336e-122	406.0	COG0280@1|root,COG0280@2|Bacteria,2J5DS@203691|Spirochaetes	203691|Spirochaetes	C	phosphate acetyltransferase	pta	-	2.3.1.8	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	PTA_PTB
SX3_k127_2618096_56	665571.STHERM_c08680	1.55e-91	307.0	COG0289@1|root,COG0289@2|Bacteria,2J647@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
SX3_k127_2618096_39	665571.STHERM_c08670	5.629e-109	362.0	COG0329@1|root,COG0329@2|Bacteria,2J5J6@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
SX3_k127_2618096_85	158189.SpiBuddy_1990	1.589e-62	227.0	COG0030@1|root,COG0030@2|Bacteria,2J65T@203691|Spirochaetes	203691|Spirochaetes	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
SX3_k127_2618096_118	665571.STHERM_c08650	5.813e-25	120.0	COG0658@1|root,COG0658@2|Bacteria	2|Bacteria	S	establishment of competence for transformation	comE	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
SX3_k127_2618096_74	573413.Spirs_1506	2.536e-78	279.0	COG1413@1|root,COG1413@2|Bacteria,2J7D8@203691|Spirochaetes	203691|Spirochaetes	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2618096_31	1123274.KB899409_gene438	1.694e-121	401.0	COG5581@1|root,COG5581@2|Bacteria,2J6AM@203691|Spirochaetes	203691|Spirochaetes	M	Type IV pilus assembly	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
SX3_k127_2618096_119	573413.Spirs_1504	3.725e-24	117.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	3.4.11.19	ko:K01266,ko:K07052	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Abi
SX3_k127_2618096_107	545695.TREAZ_1586	3.703e-38	154.0	COG0526@1|root,COG0526@2|Bacteria,2J8ET@203691|Spirochaetes	203691|Spirochaetes	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
SX3_k127_2618096_10	665571.STHERM_c20440	1.147e-176	561.0	COG0156@1|root,COG0156@2|Bacteria,2J615@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	-	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
SX3_k127_2618096_47	665571.STHERM_c08590	3.473e-101	357.0	COG0825@1|root,COG0825@2|Bacteria,2J5PA@203691|Spirochaetes	203691|Spirochaetes	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
SX3_k127_2618096_51	665571.STHERM_c08580	5.582e-97	335.0	COG0777@1|root,COG0777@2|Bacteria,2J5W0@203691|Spirochaetes	203691|Spirochaetes	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
SX3_k127_2618096_9	665571.STHERM_c08570	1.853e-181	580.0	COG0439@1|root,COG0439@2|Bacteria,2J5D2@203691|Spirochaetes	203691|Spirochaetes	I	Biotin carboxylase	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
SX3_k127_2618096_106	665571.STHERM_c08560	8.364e-39	150.0	COG0511@1|root,COG0511@2|Bacteria,2J83W@203691|Spirochaetes	203691|Spirochaetes	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
SX3_k127_2618096_94	665571.STHERM_c08550	2.353e-53	191.0	COG0764@1|root,COG0764@2|Bacteria,2J7PK@203691|Spirochaetes	203691|Spirochaetes	I	dehydratase	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
SX3_k127_2618096_126	796945.HMPREF1145_1962	1.562e-18	100.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia	186801|Clostridia	NT	methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
SX3_k127_2618096_5	573413.Spirs_3670	2.481e-191	614.0	COG3437@1|root,COG3437@2|Bacteria,2JBCG@203691|Spirochaetes	203691|Spirochaetes	KT	COGs COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5,PAS_9
SX3_k127_2618096_98	760011.Spico_1353	1.408e-49	193.0	COG4191@1|root,COG4191@2|Bacteria,2J87U@203691|Spirochaetes	203691|Spirochaetes	T	Signal transduction histidine kinase	-	-	2.7.13.3	ko:K07709	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
SX3_k127_2618096_32	429009.Adeg_0173	1.715e-116	391.0	COG2204@1|root,COG2204@2|Bacteria,1VSKG@1239|Firmicutes,24ZP4@186801|Clostridia,42J66@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	ko:K02481,ko:K07714,ko:K10943	ko02020,ko05111,map02020,map05111	M00500,M00515	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
SX3_k127_2618096_21	1123274.KB899407_gene185	5.403e-154	500.0	COG1639@1|root,COG1639@2|Bacteria,2J5NU@203691|Spirochaetes	203691|Spirochaetes	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
SX3_k127_2618096_0	588581.Cpap_1800	1.661e-239	752.0	COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,2480U@186801|Clostridia,3WGYC@541000|Ruminococcaceae	186801|Clostridia	H	Thiamine pyrophosphate enzyme, central domain	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
SX3_k127_2618096_97	351627.Csac_1143	5.677e-50	184.0	COG0440@1|root,COG0440@2|Bacteria,1V2AJ@1239|Firmicutes,24HZM@186801|Clostridia,42GAW@68295|Thermoanaerobacterales	186801|Clostridia	E	Acetolactate synthase, small subunit	ilvH	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
SX3_k127_2618096_6	498761.HM1_1515	1.427e-189	614.0	COG0119@1|root,COG0119@2|Bacteria,1TP4Y@1239|Firmicutes,2485A@186801|Clostridia	186801|Clostridia	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
SX3_k127_2618096_14	289377.HL41_01260	1.148e-163	529.0	COG0065@1|root,COG0065@2|Bacteria,2GH30@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
SX3_k127_2618096_91	1089553.Tph_c19820	5.068e-56	202.0	COG0066@1|root,COG0066@2|Bacteria,1V1I6@1239|Firmicutes,24FUI@186801|Clostridia,42G3R@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
SX3_k127_2618096_3	665571.STHERM_c09420	3.74e-222	699.0	COG0119@1|root,COG0119@2|Bacteria,2J6AF@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
SX3_k127_2618096_130	383372.Rcas_0145	9.786e-15	85.0	COG2197@1|root,COG3055@1|root,COG2197@2|Bacteria,COG3055@2|Bacteria,2G6NU@200795|Chloroflexi,375Q0@32061|Chloroflexia	32061|Chloroflexia	KT	PFAM regulatory protein LuxR	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Kelch_1,Kelch_4
SX3_k127_2618096_124	265072.Mfla_1690	1.179e-19	91.0	2DNS2@1|root,32YVY@2|Bacteria,1N9QQ@1224|Proteobacteria,2VY3B@28216|Betaproteobacteria,2KNXC@206350|Nitrosomonadales	206350|Nitrosomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2618096_120	75379.Tint_0627	1.087e-23	105.0	COG2929@1|root,COG2929@2|Bacteria,1N3AZ@1224|Proteobacteria	1224|Proteobacteria	S	Ribonuclease toxin, BrnT, of type II toxin-antitoxin system	-	-	-	ko:K09803	-	-	-	-	ko00000	-	-	-	BrnT_toxin
SX3_k127_2618096_127	459495.SPLC1_S204150	7.257e-18	83.0	COG1724@1|root,COG1724@2|Bacteria,1G81S@1117|Cyanobacteria	1117|Cyanobacteria	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
SX3_k127_2618096_142	643473.KB235930_gene970	0.0002999	44.0	COG1724@1|root,COG1724@2|Bacteria,1G81S@1117|Cyanobacteria,1HTHG@1161|Nostocales	1117|Cyanobacteria	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
SX3_k127_2618096_117	671143.DAMO_2546	2.3e-28	115.0	COG1598@1|root,COG1598@2|Bacteria	2|Bacteria	N	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2618096_64	926550.CLDAP_40680	3.946e-85	296.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	ycjP	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX3_k127_2618096_75	926550.CLDAP_40690	3.998e-77	269.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	ko:K02025,ko:K05814,ko:K10118,ko:K10237,ko:K10241,ko:K15771,ko:K17235,ko:K17242,ko:K17316	ko02010,map02010	M00196,M00198,M00204,M00206,M00207,M00491,M00600,M00602,M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.17,3.A.1.1.2,3.A.1.1.23,3.A.1.1.24,3.A.1.1.28,3.A.1.1.3,3.A.1.1.30,3.A.1.1.34,3.A.1.1.39	-	-	BPD_transp_1
SX3_k127_2618096_25	926550.CLDAP_40700	4.165e-141	464.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
SX3_k127_2618096_42	573413.Spirs_2373	3.681e-106	356.0	COG0664@1|root,COG4191@1|root,COG0664@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	hoxI	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	EAL,FliG_C,HATPase_c,HisKA,cNMP_binding
SX3_k127_2618096_111	1045858.Bint_0522	1.265e-34	138.0	COG1664@1|root,COG1664@2|Bacteria,2J82J@203691|Spirochaetes	203691|Spirochaetes	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
SX3_k127_2618096_66	1123274.KB899419_gene1903	1.455e-83	285.0	2EY48@1|root,33RD4@2|Bacteria,2J65N@203691|Spirochaetes	203691|Spirochaetes	N	flagellar filament outer layer protein	-	-	-	-	-	-	-	-	-	-	-	-	FlaA
SX3_k127_2618096_78	1123274.KB899419_gene1902	1.267e-73	255.0	2EY48@1|root,33UVP@2|Bacteria,2J5KT@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar filament outer layer protein FlaA	-	-	-	-	-	-	-	-	-	-	-	-	FlaA
SX3_k127_2618096_68	903818.KI912268_gene2881	4.318e-81	282.0	COG0320@1|root,COG0320@2|Bacteria,3Y6DY@57723|Acidobacteria	57723|Acidobacteria	H	Elongator protein 3, MiaB family, Radical SAM	-	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
SX3_k127_2618096_19	639282.DEFDS_0062	2.11e-156	498.0	COG0191@1|root,COG0191@2|Bacteria,2GETH@200930|Deferribacteres	200930|Deferribacteres	G	Fructose-bisphosphate aldolase class-II	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
SX3_k127_2618096_72	880073.Calab_0417	1.788e-79	276.0	COG1143@1|root,COG1143@2|Bacteria,2NQ09@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	asrA	-	-	ko:K16950	ko00920,ko01120,map00920,map01120	-	R00858,R10146	RC00065	ko00000,ko00001	-	-	-	Fer4_22
SX3_k127_2618096_43	572477.Alvin_0809	6.97e-105	347.0	COG0543@1|root,COG0543@2|Bacteria,1MV72@1224|Proteobacteria,1T4D8@1236|Gammaproteobacteria,1X2TA@135613|Chromatiales	135613|Chromatiales	C	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
SX3_k127_2618096_58	880073.Calab_0419	1.141e-90	304.0	COG1941@1|root,COG1941@2|Bacteria	2|Bacteria	C	coenzyme F420 hydrogenase activity	hoxY	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
SX3_k127_2618096_16	880073.Calab_0420	2.442e-161	520.0	COG3259@1|root,COG3259@2|Bacteria	2|Bacteria	C	Nickel-dependent hydrogenase	hoxH	-	1.12.1.2,1.8.98.5	ko:K00436,ko:K14126	ko00680,map00680	-	R00019,R00700,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
SX3_k127_2618096_135	338966.Ppro_2796	2.187e-09	66.0	COG0680@1|root,COG0680@2|Bacteria	2|Bacteria	C	spore germination	-	-	3.4.23.51	ko:K00442,ko:K08315	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000,ko01002	-	-	-	HycI
SX3_k127_2618096_103	880073.Calab_0422	1.155e-41	156.0	COG0745@1|root,COG0745@2|Bacteria,2NRCE@2323|unclassified Bacteria	2|Bacteria	KT	cheY-homologous receiver domain	-	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
SX3_k127_2618096_22	889378.Spiaf_2151	2.7e-151	486.0	COG0035@1|root,COG0035@2|Bacteria,2J5NG@203691|Spirochaetes	203691|Spirochaetes	F	uracil phosphoribosyltransferase	upp	-	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
SX3_k127_2618096_11	269799.Gmet_0119	2.722e-175	577.0	COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,42M3G@68525|delta/epsilon subdivisions,2WJ51@28221|Deltaproteobacteria,43S2B@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	iAF987.Gmet_0119	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
SX3_k127_2618096_132	1094715.CM001373_gene2355	1.318e-11	67.0	COG0298@1|root,COG0298@2|Bacteria,1N76Y@1224|Proteobacteria,1SCGX@1236|Gammaproteobacteria,1JFCB@118969|Legionellales	118969|Legionellales	O	HupF/HypC family	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
SX3_k127_2618096_54	1232410.KI421412_gene172	1.986e-95	324.0	COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,42M6R@68525|delta/epsilon subdivisions,2WJDQ@28221|Deltaproteobacteria,43U45@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	TIGRFAM hydrogenase expression formation protein HypD	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	iAF987.Gmet_0117	HypD
SX3_k127_2618096_60	365528.KB891214_gene2427	6.968e-89	306.0	COG0309@1|root,COG0309@2|Bacteria,2GJ7N@201174|Actinobacteria	201174|Actinobacteria	O	hydrogenase expression formation protein HypE	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
SX3_k127_2618096_82	243275.TDE_1684	1.079e-63	226.0	COG0503@1|root,COG0503@2|Bacteria,2J7CM@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
SX3_k127_2618096_140	744872.Spica_0777	7.92e-05	51.0	2ANTA@1|root,31DTJ@2|Bacteria,2JB0G@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2618096_29	906968.Trebr_1828	6.274e-131	436.0	COG0533@1|root,COG0533@2|Bacteria,2J5WG@203691|Spirochaetes	203691|Spirochaetes	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
SX3_k127_2618096_90	665571.STHERM_c07330	6.676e-58	212.0	COG2861@1|root,COG2861@2|Bacteria,2J75Z@203691|Spirochaetes	203691|Spirochaetes	S	Divergent polysaccharide deacetylase	-	-	-	ko:K09798	-	-	-	-	ko00000	-	-	-	Polysacc_deac_2
SX3_k127_2618096_49	744872.Spica_0849	3.325e-99	331.0	COG0568@1|root,COG0568@2|Bacteria,2J7R0@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoS	-	-	ko:K03086,ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
SX3_k127_2618096_125	390236.BafPKo_0797	6.263e-19	89.0	COG3951@1|root,COG3951@2|Bacteria	2|Bacteria	MNO	Flagellar rod assembly protein muramidase FlgJ	flgJ	-	-	ko:K02395,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02035	-	GH23	-	Rod-binding
SX3_k127_2618096_81	469381.Dpep_1974	7.063e-66	237.0	COG1706@1|root,COG1706@2|Bacteria,3TA0P@508458|Synergistetes	508458|Synergistetes	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgI	-	-	ko:K02394	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgI
SX3_k127_2618096_28	1307761.L21SP2_1417	1.895e-132	427.0	COG4786@1|root,COG4786@2|Bacteria,2J57D@203691|Spirochaetes	203691|Spirochaetes	N	flagellar basal-body rod protein FlgG	flgG	-	-	ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
SX3_k127_2618096_34	665571.STHERM_c07290	7.662e-116	379.0	COG4786@1|root,COG4786@2|Bacteria,2J5EJ@203691|Spirochaetes	203691|Spirochaetes	N	flagellar basal-body rod protein	flhO	-	-	ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
SX3_k127_2618096_24	926569.ANT_12900	7.789e-144	465.0	COG0683@1|root,COG0683@2|Bacteria,2G6Q1@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
SX3_k127_2618096_27	926569.ANT_12890	1.771e-132	433.0	COG0559@1|root,COG0559@2|Bacteria,2G6FM@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
SX3_k127_2618096_35	926569.ANT_12880	8.792e-116	388.0	COG4177@1|root,COG4177@2|Bacteria,2G6D8@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
SX3_k127_2618096_37	926569.ANT_12870	1.645e-110	363.0	COG0411@1|root,COG0411@2|Bacteria,2G5W6@200795|Chloroflexi	200795|Chloroflexi	E	PFAM ABC transporter related	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
SX3_k127_2618096_50	1121472.AQWN01000006_gene1813	1.987e-98	327.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia,260MZ@186807|Peptococcaceae	186801|Clostridia	E	PFAM ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
SX3_k127_2618096_57	573413.Spirs_1737	7.939e-91	308.0	COG0664@1|root,COG0664@2|Bacteria,2J6ZR@203691|Spirochaetes	203691|Spirochaetes	K	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
SX3_k127_2618096_46	744872.Spica_0772	5.812e-102	343.0	COG0664@1|root,COG1729@1|root,COG0664@2|Bacteria,COG1729@2|Bacteria,2J5MQ@203691|Spirochaetes	203691|Spirochaetes	T	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_16,TPR_2,TPR_6,TPR_8,cNMP_binding
SX3_k127_2618096_20	744872.Spica_0771	3.054e-155	500.0	COG0402@1|root,COG0402@2|Bacteria,2J6KS@203691|Spirochaetes	203691|Spirochaetes	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
SX3_k127_2618096_40	889378.Spiaf_1858	4.765e-108	359.0	COG0568@1|root,COG0568@2|Bacteria,2J71G@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
SX3_k127_2618096_113	573413.Spirs_2240	6.32e-33	141.0	COG1388@1|root,COG4942@1|root,COG1388@2|Bacteria,COG4942@2|Bacteria,2J72G@203691|Spirochaetes	203691|Spirochaetes	M	LysM domain M23 M37 peptidase domain protein	lysM	-	-	ko:K06194	-	-	-	-	ko00000	1.A.34.1.2	-	-	Amidase_3,LysM,Peptidase_M23
SX3_k127_2618096_44	889378.Spiaf_2248	1.932e-104	374.0	COG1120@1|root,COG1120@2|Bacteria,2J7N3@203691|Spirochaetes	203691|Spirochaetes	HP	ATPases associated with a variety of cellular activities	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
SX3_k127_2618096_62	1307761.L21SP2_2857	1.109e-85	295.0	COG0609@1|root,COG0609@2|Bacteria,2J6D8@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
SX3_k127_2618096_86	889378.Spiaf_2246	4.725e-62	228.0	COG0614@1|root,COG0614@2|Bacteria	2|Bacteria	P	abc-type fe3 -hydroxamate transport system, periplasmic component	hmuT	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
SX3_k127_2618096_121	1379281.AVAG01000010_gene1321	2.004e-20	93.0	2E32K@1|root,32Y2U@2|Bacteria,1NJTE@1224|Proteobacteria,42WY3@68525|delta/epsilon subdivisions,2WSR9@28221|Deltaproteobacteria,2MD7A@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2618096_101	573413.Spirs_3156	2.494e-46	177.0	2F691@1|root,33YSU@2|Bacteria,2J6FP@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2618096_65	1480694.DC28_03140	7.59e-84	292.0	COG2206@1|root,COG2206@2|Bacteria,2J6CD@203691|Spirochaetes	203691|Spirochaetes	T	HD domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
SX3_k127_2618096_8	573413.Spirs_3160	9.388e-182	602.0	COG0441@1|root,COG0572@1|root,COG0441@2|Bacteria,COG0572@2|Bacteria,2J578@203691|Spirochaetes	203691|Spirochaetes	F	PFAM Phosphoribulokinase Uridine kinase family	-	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
SX3_k127_2618096_15	237368.SCABRO_00441	1.33e-163	527.0	COG1236@1|root,COG1236@2|Bacteria,2IXNS@203682|Planctomycetes	203682|Planctomycetes	J	Exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_2,Lactamase_B_6,RMMBL
SX3_k127_2618096_128	742818.HMPREF9451_00333	1.996e-17	93.0	COG2983@1|root,COG2983@2|Bacteria	2|Bacteria	S	Putative zinc- or iron-chelating domain	ycgN	-	-	ko:K09160	-	-	-	-	ko00000	-	-	-	CxxCxxCC
SX3_k127_2618096_133	1349820.M707_19970	1.714e-10	70.0	2E64T@1|root,330TJ@2|Bacteria,2H60Q@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2618096_84	1123274.KB899408_gene3947	8.624e-63	220.0	COG1014@1|root,COG1014@2|Bacteria,2J8M0@203691|Spirochaetes	203691|Spirochaetes	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
SX3_k127_2618096_38	877418.ATWV01000009_gene364	3.121e-109	358.0	COG1013@1|root,COG1013@2|Bacteria,2J6R4@203691|Spirochaetes	203691|Spirochaetes	C	oxidoreductase beta subunit	-	-	1.2.7.11,1.2.7.3,1.2.7.7	ko:K00175,ko:K00187	ko00010,ko00020,ko00280,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197,R07160,R08566,R08567	RC00004,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
SX3_k127_2618096_23	573413.Spirs_0610	7.021e-146	469.0	COG0674@1|root,COG0674@2|Bacteria,2J65R@203691|Spirochaetes	203691|Spirochaetes	C	oxidoreductase, alpha subunit	porA6	-	1.2.7.11,1.2.7.3,1.2.7.7	ko:K00174,ko:K00186	ko00010,ko00020,ko00280,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197,R07160,R08566,R08567	RC00004,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
SX3_k127_2618096_123	1123274.KB899408_gene3944	2.389e-20	92.0	COG1146@1|root,COG1146@2|Bacteria,2J9EV@203691|Spirochaetes	203691|Spirochaetes	C	4Fe-4S binding domain	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_7
SX3_k127_2618096_79	935948.KE386495_gene1221	3.68e-70	243.0	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia,42FJI@68295|Thermoanaerobacterales	186801|Clostridia	S	Methionine synthase B12-binding module cap domain protein	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
SX3_k127_2618096_33	243276.TPANIC_0421	2.384e-116	399.0	COG0457@1|root,COG3391@1|root,COG0457@2|Bacteria,COG3391@2|Bacteria,2J5QG@203691|Spirochaetes	203691|Spirochaetes	S	NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	NHL,TPR_11
SX3_k127_2618096_92	1123274.KB899429_gene2900	1.852e-55	204.0	COG0457@1|root,COG0457@2|Bacteria,2J6BA@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_16,TPR_2,TPR_6,TPR_8
SX3_k127_2618096_70	1123274.KB899429_gene2901	6.303e-80	273.0	COG0496@1|root,COG0496@2|Bacteria,2J7HR@203691|Spirochaetes	203691|Spirochaetes	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
SX3_k127_2618096_36	1123274.KB899429_gene2902	3.038e-112	376.0	COG0153@1|root,COG0153@2|Bacteria,2J58W@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the GHMP kinase family	-	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
SX3_k127_2618096_134	665571.STHERM_c07260	8.194e-10	69.0	COG0664@1|root,COG0664@2|Bacteria,2J6ZR@203691|Spirochaetes	203691|Spirochaetes	K	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
SX3_k127_2618096_110	754027.HMPREF9554_00051	4.638e-37	146.0	2FBAD@1|root,343GE@2|Bacteria,2J7WU@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2618096_76	479434.Sthe_2697	2.809e-76	265.0	COG1656@1|root,COG1977@1|root,COG1656@2|Bacteria,COG1977@2|Bacteria,2G6GZ@200795|Chloroflexi,27Y8I@189775|Thermomicrobia	189775|Thermomicrobia	H	Mut7-C ubiquitin	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C,Ub-Mut7C
SX3_k127_2618096_89	1230342.CTM_18924	1.211e-60	220.0	COG1266@1|root,COG1266@2|Bacteria,1VH5V@1239|Firmicutes,24QGF@186801|Clostridia,36MXP@31979|Clostridiaceae	186801|Clostridia	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
SX3_k127_2618096_115	221027.JO40_11775	8.123e-32	126.0	COG0254@1|root,COG0254@2|Bacteria,2J93Z@203691|Spirochaetes	203691|Spirochaetes	J	50S ribosomal protein L31	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
SX3_k127_2618096_1	744872.Spica_1604	3.997e-232	730.0	COG1158@1|root,COG1158@2|Bacteria,2J5BW@203691|Spirochaetes	203691|Spirochaetes	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
SX3_k127_2618096_52	573413.Spirs_3180	4.536e-96	329.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,2J8AZ@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM competence damage-inducible protein CinA N-terminal domain	cinA	-	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
SX3_k127_2618096_108	1307761.L21SP2_1378	1.22e-37	148.0	COG1664@1|root,COG1664@2|Bacteria,2J85N@203691|Spirochaetes	203691|Spirochaetes	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
SX3_k127_2618096_116	1480694.DC28_03070	2.126e-29	129.0	COG2114@1|root,COG2114@2|Bacteria,2JAV7@203691|Spirochaetes	203691|Spirochaetes	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2618096_61	1480694.DC28_03065	7.913e-86	290.0	COG0745@1|root,COG0745@2|Bacteria,2J7JA@203691|Spirochaetes	203691|Spirochaetes	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
SX3_k127_2618096_12	665571.STHERM_c18560	1.219e-170	552.0	COG0815@1|root,COG0815@2|Bacteria,2J60T@203691|Spirochaetes	203691|Spirochaetes	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
SX3_k127_2618096_114	760011.Spico_1237	2.057e-32	128.0	COG0776@1|root,COG0776@2|Bacteria,2J7PW@203691|Spirochaetes	203691|Spirochaetes	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hup	-	-	ko:K04764,ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
SX3_k127_2618096_131	1480694.DC28_03055	3.265e-14	76.0	COG0268@1|root,COG0268@2|Bacteria,2J84G@203691|Spirochaetes	203691|Spirochaetes	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
SX3_k127_2618096_53	545694.TREPR_2607	5.461e-96	332.0	COG5360@1|root,COG5360@2|Bacteria,2J6PR@203691|Spirochaetes	203691|Spirochaetes	S	Heparinase II/III-like protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2618096_41	717605.Theco_2601	1.335e-107	364.0	COG0524@1|root,COG0524@2|Bacteria,1TT7Y@1239|Firmicutes,4HC0B@91061|Bacilli,26U8T@186822|Paenibacillaceae	91061|Bacilli	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
SX3_k127_2618096_93	665571.STHERM_c04580	3.131e-55	211.0	COG2231@1|root,COG2231@2|Bacteria	2|Bacteria	L	endonuclease III	magIII	-	-	ko:K07457	-	-	-	-	ko00000	-	-	-	HhH-GPD
SX3_k127_2618096_26	889378.Spiaf_2782	6.97e-136	460.0	COG0815@1|root,COG0815@2|Bacteria,2J60T@203691|Spirochaetes	203691|Spirochaetes	M	Transfers the fatty acyl group on membrane lipoproteins	cutE	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
SX3_k127_2618096_13	665571.STHERM_c14370	8.386e-165	531.0	COG0162@1|root,COG0162@2|Bacteria,2J5ZS@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
SX3_k127_2618096_2	665571.STHERM_c14380	2.181e-225	704.0	COG0423@1|root,COG0423@2|Bacteria,2J57N@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
SX3_k127_2618096_7	744872.Spica_0891	1.898e-183	587.0	COG0008@1|root,COG0008@2|Bacteria,2J5M7@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
SX3_k127_2618096_18	251221.35214536	6.591e-157	519.0	COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1G4UJ@1117|Cyanobacteria	1117|Cyanobacteria	CO	Disulphide bond corrector protein DsbC	-	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_7
SX3_k127_2618096_102	665571.STHERM_c12710	7.174e-42	158.0	COG1959@1|root,COG1959@2|Bacteria,2J8PQ@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator	-	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
SX3_k127_2618096_112	1242864.D187_008136	4.873e-33	132.0	COG0371@1|root,COG0371@2|Bacteria,1NAAM@1224|Proteobacteria	1224|Proteobacteria	C	Glycerol dehydrogenase and related enzymes	egsA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
SX3_k127_2672713_12	247490.KSU1_C1464	7.031e-66	235.0	COG0053@1|root,COG0053@2|Bacteria,2IY05@203682|Planctomycetes	203682|Planctomycetes	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
SX3_k127_2672713_16	472759.Nhal_2021	1.587e-11	76.0	2DPYJ@1|root,333YW@2|Bacteria,1NCVQ@1224|Proteobacteria,1SDCB@1236|Gammaproteobacteria,1X1KX@135613|Chromatiales	135613|Chromatiales	S	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
SX3_k127_2672713_15	1150621.SMUL_1240	5.575e-24	110.0	COG3744@1|root,COG3744@2|Bacteria,1RJXF@1224|Proteobacteria,431F2@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Large family of predicted nucleotide-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	PIN
SX3_k127_2672713_9	886293.Sinac_3586	8.954e-70	244.0	COG0515@1|root,COG1335@1|root,COG0515@2|Bacteria,COG1335@2|Bacteria,2IZ3W@203682|Planctomycetes	203682|Planctomycetes	Q	Isochorismatase family	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Isochorismatase
SX3_k127_2672713_6	1499967.BAYZ01000047_gene2738	3.791e-102	340.0	COG0053@1|root,COG0053@2|Bacteria,2NPHA@2323|unclassified Bacteria	2|Bacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
SX3_k127_2672713_8	1094508.Tsac_0635	4.295e-83	280.0	COG2818@1|root,COG2818@2|Bacteria,1UYWG@1239|Firmicutes,249EP@186801|Clostridia,42FGP@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM Methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
SX3_k127_2672713_7	251229.Chro_5489	1.345e-95	323.0	COG2816@1|root,COG2816@2|Bacteria,1G3EM@1117|Cyanobacteria	1117|Cyanobacteria	L	Belongs to the Nudix hydrolase family. NudC subfamily	nudC	-	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
SX3_k127_2672713_5	1121335.Clst_0833	3.825e-113	385.0	COG1070@1|root,COG1070@2|Bacteria,1TP7Z@1239|Firmicutes,247ZU@186801|Clostridia,3WHQA@541000|Ruminococcaceae	186801|Clostridia	H	Carbohydrate kinase, FGGY family protein	rhaB	-	2.7.1.5,2.7.1.51	ko:K00848,ko:K00879	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01902,R03014,R03241	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
SX3_k127_2672713_14	1123274.KB899408_gene3811	8.997e-44	170.0	2C7TX@1|root,33VWG@2|Bacteria,2J836@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2672713_10	879212.DespoDRAFT_03034	1.627e-67	237.0	COG2199@1|root,COG3706@2|Bacteria,1N2X1@1224|Proteobacteria,42TUZ@68525|delta/epsilon subdivisions,2WQ1Q@28221|Deltaproteobacteria,2MKGE@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Carbohydrate-binding family 9	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_2
SX3_k127_2672713_11	935837.JAEK01000006_gene4236	1.805e-66	247.0	COG0395@1|root,COG0395@2|Bacteria,1TR45@1239|Firmicutes,4HCEH@91061|Bacilli,1ZCMK@1386|Bacillus	91061|Bacilli	G	COG0395 ABC-type sugar transport system, permease component	amyC1	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
SX3_k127_2672713_13	1380763.BG53_15590	5.995e-47	188.0	COG1175@1|root,COG1175@2|Bacteria,1TP1Q@1239|Firmicutes,4HCFJ@91061|Bacilli,26RGT@186822|Paenibacillaceae	91061|Bacilli	P	ABC transporter permease	amyD1	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
SX3_k127_2672713_3	1380394.JADL01000001_gene2217	1.268e-125	426.0	COG0747@1|root,COG0747@2|Bacteria,1MU3P@1224|Proteobacteria,2TT4M@28211|Alphaproteobacteria,2JQRE@204441|Rhodospirillales	204441|Rhodospirillales	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
SX3_k127_2672713_4	515635.Dtur_1707	7.281e-117	388.0	COG0601@1|root,COG0601@2|Bacteria	2|Bacteria	P	nitrogen compound transport	oppB	-	2.4.2.7	ko:K00759,ko:K02033	ko00230,ko01100,ko02024,map00230,map01100,map02024	M00239	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko00002,ko01000,ko02000,ko04147	3.A.1.5	-	-	BPD_transp_1
SX3_k127_2672713_0	266779.Meso_4487	8.316e-141	456.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2TUWG@28211|Alphaproteobacteria,43R5I@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
SX3_k127_2672713_1	1380394.JADL01000001_gene2214	7.364e-139	449.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
SX3_k127_2672713_2	383372.Rcas_2455	7.264e-132	440.0	COG4608@1|root,COG4608@2|Bacteria,2G5R5@200795|Chloroflexi,3754I@32061|Chloroflexia	200795|Chloroflexi	P	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
SX3_k127_2675749_20	1382306.JNIM01000001_gene2993	2.239e-39	149.0	COG0667@1|root,COG0667@2|Bacteria,2G5VT@200795|Chloroflexi	200795|Chloroflexi	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SX3_k127_2675749_14	665571.STHERM_c22260	2.125e-54	204.0	COG3712@1|root,COG3712@2|Bacteria	2|Bacteria	PT	iron ion homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	DUF389,FecR
SX3_k127_2675749_21	485914.Hmuk_3414	2.543e-31	142.0	COG0613@1|root,arCOG00302@2157|Archaea	2157|Archaea	E	metal-dependent phosphoesterases (PHP family)	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux,CarboxypepD_reg,DDOST_48kD
SX3_k127_2675749_0	926569.ANT_16800	3.715e-209	659.0	COG1003@1|root,COG1003@2|Bacteria,2G5MU@200795|Chloroflexi	200795|Chloroflexi	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
SX3_k127_2675749_2	1128421.JAGA01000002_gene784	8.777e-152	496.0	COG0403@1|root,COG0403@2|Bacteria,2NNP1@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006807,GO:0008150,GO:0008152,GO:0009069,GO:0009987,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019752,GO:0032991,GO:0042133,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901605,GO:1902494,GO:1990204	1.4.4.2	ko:K00281,ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
SX3_k127_2675749_19	1307761.L21SP2_0011	1.81e-39	150.0	COG0509@1|root,COG0509@2|Bacteria,2J8D7@203691|Spirochaetes	203691|Spirochaetes	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
SX3_k127_2675749_6	383372.Rcas_2285	2.321e-105	354.0	COG0404@1|root,COG0404@2|Bacteria,2G5VA@200795|Chloroflexi,3756Q@32061|Chloroflexia	32061|Chloroflexia	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
SX3_k127_2675749_18	926569.ANT_12060	2.392e-47	184.0	COG1765@1|root,COG1765@2|Bacteria,2G6Y1@200795|Chloroflexi	200795|Chloroflexi	O	PFAM OsmC family protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
SX3_k127_2675749_17	1123274.KB899417_gene2080	2.388e-48	177.0	COG2606@1|root,COG2606@2|Bacteria,2J8HJ@203691|Spirochaetes	203691|Spirochaetes	S	YbaK prolyl-tRNA synthetase associated region	ybaK	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
SX3_k127_2675749_7	744872.Spica_0753	1.223e-104	344.0	COG0807@1|root,COG0807@2|Bacteria,2J9XB@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	-	-	3.5.4.25	ko:K01497	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125	R00425	RC00293,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydro2
SX3_k127_2675749_9	573413.Spirs_0051	8.485e-91	302.0	COG1428@1|root,COG1428@2|Bacteria,2JAVV@203691|Spirochaetes	203691|Spirochaetes	F	Deoxynucleoside kinase	dck	-	2.7.1.74	ko:K00893	ko00230,ko00240,ko01100,map00230,map00240,map01100	-	R00185,R01666	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	dNK
SX3_k127_2675749_1	1480694.DC28_05045	8.659e-185	585.0	COG0436@1|root,COG0436@2|Bacteria,2J6H6@203691|Spirochaetes	203691|Spirochaetes	H	Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate	dapL	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
SX3_k127_2675749_15	926560.KE387023_gene2884	2.401e-53	208.0	COG2318@1|root,COG2318@2|Bacteria,1WMM8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
SX3_k127_2675749_8	573413.Spirs_0575	5.26e-98	331.0	COG3294@1|root,COG3294@2|Bacteria,2J5Z4@203691|Spirochaetes	203691|Spirochaetes	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K09163	-	-	-	-	ko00000	-	-	-	-
SX3_k127_2675749_16	927658.AJUM01000047_gene2754	2.81e-52	190.0	COG1335@1|root,COG1335@2|Bacteria,4NS3S@976|Bacteroidetes,2FXXN@200643|Bacteroidia,3XK20@558415|Marinilabiliaceae	976|Bacteroidetes	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
SX3_k127_2675749_11	660470.Theba_0046	3.332e-77	271.0	COG0697@1|root,COG0697@2|Bacteria,2GDSN@200918|Thermotogae	200918|Thermotogae	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SX3_k127_2675749_12	768704.Desmer_3201	4.511e-65	233.0	COG0697@1|root,COG0697@2|Bacteria,1TRKE@1239|Firmicutes,249RU@186801|Clostridia,2631B@186807|Peptococcaceae	186801|Clostridia	EG	DMT(Drug metabolite transporter) superfamily permease	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SX3_k127_2675749_13	1123274.KB899410_gene3392	2.228e-58	220.0	COG0584@1|root,COG0584@2|Bacteria,2J6RW@203691|Spirochaetes	203691|Spirochaetes	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
SX3_k127_2675749_5	1499967.BAYZ01000019_gene6335	8.341e-107	353.0	COG1177@1|root,COG1177@2|Bacteria	2|Bacteria	P	DNA import into cell involved in transformation	Z012_03370	-	-	ko:K02053	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
SX3_k127_2675749_10	545694.TREPR_0086	2.552e-77	268.0	COG1176@1|root,COG1176@2|Bacteria	2|Bacteria	P	putrescine transport	Z012_03375	-	-	ko:K02054	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
SX3_k127_2675749_3	545694.TREPR_0085	4.198e-111	370.0	COG3842@1|root,COG3842@2|Bacteria,2J7DW@203691|Spirochaetes	203691|Spirochaetes	P	ABC transporter	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
SX3_k127_2675749_4	1499967.BAYZ01000019_gene6334	5.602e-107	355.0	COG4134@1|root,COG4134@2|Bacteria	2|Bacteria	S	Bacterial extracellular solute-binding protein	-	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_8
SX3_k127_2685338_3	526218.Sterm_3772	6.665e-37	143.0	COG1071@1|root,COG1071@2|Bacteria,3785C@32066|Fusobacteria	32066|Fusobacteria	C	Dehydrogenase E1 component	-	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
SX3_k127_2685338_0	1122947.FR7_1921	1.116e-137	447.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,4H3G6@909932|Negativicutes	1239|Firmicutes	C	Transketolase, pyrimidine binding domain	acoB	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
SX3_k127_2685338_1	1235797.C816_00190	3.964e-80	280.0	COG0508@1|root,COG0508@2|Bacteria,1TR5N@1239|Firmicutes,247Q5@186801|Clostridia,2N72V@216572|Oscillospiraceae	186801|Clostridia	C	dehydrogenase E2 component	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
SX3_k127_2685338_2	670487.Ocepr_1040	6.167e-55	211.0	COG2390@1|root,COG2390@2|Bacteria,1WMUX@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	Putative sugar-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Sugar-bind
SX3_k127_2709601_2	331678.Cphamn1_1145	2.421e-127	421.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	int	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
SX3_k127_2709601_8	765420.OSCT_1984	1.672e-39	163.0	COG0457@1|root,COG0457@2|Bacteria,2G9ET@200795|Chloroflexi,377NS@32061|Chloroflexia	32061|Chloroflexia	NU	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
SX3_k127_2709601_1	1123274.KB899410_gene3466	1.435e-217	697.0	COG1674@1|root,COG1674@2|Bacteria,2J63D@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the FtsK SpoIIIE SftA family	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
SX3_k127_2709601_7	1125700.HMPREF9195_00645	2.666e-48	197.0	COG0741@1|root,COG0741@2|Bacteria,2J7A5@203691|Spirochaetes	203691|Spirochaetes	M	transglycosylase	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,TPR_6
SX3_k127_2709601_6	1123274.KB899410_gene3463	1.185e-48	188.0	COG1652@1|root,COG1652@2|Bacteria,2J6RK@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HSP70,LysM
SX3_k127_2709601_4	573413.Spirs_3827	2.252e-95	330.0	COG0457@1|root,COG0457@2|Bacteria,2J5RJ@203691|Spirochaetes	203691|Spirochaetes	S	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Mrr_cat,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
SX3_k127_2709601_9	545695.TREAZ_2579	2.756e-29	130.0	COG0357@1|root,COG0357@2|Bacteria,2J72Y@203691|Spirochaetes	203691|Spirochaetes	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
SX3_k127_2709601_0	665571.STHERM_c02920	1.017e-239	757.0	COG0445@1|root,COG0445@2|Bacteria,2J5A1@203691|Spirochaetes	203691|Spirochaetes	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
SX3_k127_2709601_3	665571.STHERM_c02910	2.096e-125	417.0	COG0486@1|root,COG0486@2|Bacteria,2J5GU@203691|Spirochaetes	203691|Spirochaetes	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
SX3_k127_2709601_5	509191.AEDB02000003_gene999	2.383e-52	191.0	COG0730@1|root,COG0730@2|Bacteria,1TPMA@1239|Firmicutes,25CI8@186801|Clostridia,3WJ6E@541000|Ruminococcaceae	186801|Clostridia	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
SX3_k127_2734913_16	7994.ENSAMXP00000011899	8.954e-35	153.0	COG5279@1|root,KOG4575@2759|Eukaryota,39WFT@33154|Opisthokonta,3BIKZ@33208|Metazoa,3D1NX@33213|Bilateria,480EJ@7711|Chordata,490B6@7742|Vertebrata,49WTK@7898|Actinopterygii	33208|Metazoa	D	Kyphoscoliosis peptidase	-	-	-	-	-	-	-	-	-	-	-	-	CAP_GLY,Transglut_core
SX3_k127_2734913_19	1121934.AUDX01000006_gene2021	4.881e-28	116.0	2EG8Z@1|root,332XF@2|Bacteria,2GTHG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2734913_17	471854.Dfer_5567	1.192e-33	133.0	COG1695@1|root,COG1695@2|Bacteria,4NQWD@976|Bacteroidetes,47Y0M@768503|Cytophagia	976|Bacteroidetes	K	Domain of unknown function (DUF4180)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4180
SX3_k127_2734913_0	879212.DespoDRAFT_03206	2.43e-318	994.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MHRD@213118|Desulfobacterales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
SX3_k127_2734913_13	323259.Mhun_1454	1.807e-37	148.0	COG1487@1|root,arCOG02219@2157|Archaea	2157|Archaea	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
SX3_k127_2734913_6	867845.KI911784_gene101	7.774e-101	340.0	COG0578@1|root,COG0578@2|Bacteria,2G63S@200795|Chloroflexi,3750F@32061|Chloroflexia	32061|Chloroflexia	C	BFD domain protein 2Fe-2S -binding domain protein	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,Fer2_BFD
SX3_k127_2734913_5	665571.STHERM_c19210	9.554e-109	379.0	COG4412@1|root,COG4412@2|Bacteria,2JAS0@203691|Spirochaetes	203691|Spirochaetes	S	Peptidase M30	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M30
SX3_k127_2734913_7	378806.STAUR_3780	5.509e-80	280.0	COG4307@1|root,COG4307@2|Bacteria,1MXES@1224|Proteobacteria,42SJI@68525|delta/epsilon subdivisions,2WPX2@28221|Deltaproteobacteria,2YV2D@29|Myxococcales	28221|Deltaproteobacteria	S	Putative zinc-binding metallo-peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_Mx
SX3_k127_2734913_10	1121918.ARWE01000001_gene2996	2.843e-56	210.0	COG1181@1|root,COG1181@2|Bacteria,1N4F5@1224|Proteobacteria,42NYM@68525|delta/epsilon subdivisions,2WKTX@28221|Deltaproteobacteria,43U6N@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	ATP-grasp domain	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
SX3_k127_2734913_9	889378.Spiaf_2834	5.661e-62	225.0	COG0791@1|root,COG0791@2|Bacteria,2J73P@203691|Spirochaetes	203691|Spirochaetes	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_4
SX3_k127_2734913_11	180332.JTGN01000003_gene1990	3.076e-49	194.0	COG0407@1|root,COG0407@2|Bacteria,1TW8J@1239|Firmicutes,24BSH@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_2734913_2	1499967.BAYZ01000050_gene2788	4.153e-181	578.0	COG1904@1|root,COG1904@2|Bacteria	2|Bacteria	G	glucuronate isomerase activity	uxaC	GO:0005975,GO:0005996,GO:0006063,GO:0006064,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0019585,GO:0019586,GO:0019698,GO:0019752,GO:0032787,GO:0042839,GO:0042840,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046396,GO:0046397,GO:0071704,GO:0072329,GO:1901575	5.3.1.12	ko:K01812	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	iPC815.YPO0579,iSbBS512_1146.SbBS512_E3528	UxaC
SX3_k127_2734913_18	324602.Caur_3102	4.075e-32	131.0	COG0727@1|root,32S46@2|Bacteria,2G78K@200795|Chloroflexi,377J9@32061|Chloroflexia	32061|Chloroflexia	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
SX3_k127_2734913_12	573413.Spirs_0105	1.022e-43	174.0	COG1146@1|root,COG1146@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_9,Flavodoxin_5
SX3_k127_2734913_1	573413.Spirs_0106	2.509e-295	919.0	COG1053@1|root,COG1053@2|Bacteria	2|Bacteria	C	succinate dehydrogenase	aprA	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
SX3_k127_2734913_15	933262.AXAM01000030_gene796	3.916e-35	140.0	COG1669@1|root,COG1669@2|Bacteria,1PT4U@1224|Proteobacteria,432I8@68525|delta/epsilon subdivisions,2WYHT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2734913_21	159749.K0R6J4	0.0004455	46.0	COG0790@1|root,KOG1550@2759|Eukaryota,2XET5@2836|Bacillariophyta	2836|Bacillariophyta	MOT	Sel1-like repeats.	-	-	-	ko:K14026	ko04141,map04141	M00403	-	-	ko00000,ko00001,ko00002	-	-	-	-
SX3_k127_2734913_3	1123274.KB899412_gene1479	3.945e-177	567.0	COG1488@1|root,COG1488@2|Bacteria,2J5IF@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
SX3_k127_2734913_8	1304284.L21TH_1610	4.015e-77	267.0	COG0717@1|root,COG0717@2|Bacteria,1V1BE@1239|Firmicutes,24A3M@186801|Clostridia,36G9F@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD,dUTPase
SX3_k127_2734913_4	744872.Spica_1337	2.957e-116	388.0	COG2089@1|root,COG2089@2|Bacteria,2J662@203691|Spirochaetes	203691|Spirochaetes	M	Sialic acid synthase	-	-	2.5.1.56	ko:K01654	ko00520,ko01100,map00520,map01100	-	R01804,R04435	RC00159	ko00000,ko00001,ko01000	-	-	-	NeuB,SAF
SX3_k127_2734913_14	521460.Athe_0304	6.058e-37	149.0	2E25X@1|root,32XCM@2|Bacteria,1UJJ7@1239|Firmicutes,25F48@186801|Clostridia,42J75@68295|Thermoanaerobacterales	186801|Clostridia	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
SX3_k127_2757_1	869210.Marky_0877	5.825e-34	134.0	COG0697@1|root,COG0697@2|Bacteria,1WI4X@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EG	PFAM EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SX3_k127_2757_2	1220534.B655_1615	2.14e-22	104.0	COG2246@1|root,arCOG02228@2157|Archaea,2Y20I@28890|Euryarchaeota,23PR3@183925|Methanobacteria	183925|Methanobacteria	S	PFAM GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
SX3_k127_2757_0	748449.Halha_1744	1.765e-53	203.0	COG1609@1|root,COG1609@2|Bacteria,1TP9Q@1239|Firmicutes,24ARJ@186801|Clostridia,3WBV1@53433|Halanaerobiales	186801|Clostridia	K	PFAM Bacterial regulatory proteins, gntR family	-	-	-	ko:K02103	-	-	-	-	ko00000,ko03000	-	-	-	GntR,Peripla_BP_3
SX3_k127_278344_6	485913.Krac_11477	1.488e-102	343.0	COG3415@1|root,COG3415@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013,HTH_Tnp_4
SX3_k127_278344_14	421531.IX38_16255	3.913e-42	164.0	COG0610@1|root,COG0610@2|Bacteria,4NFJ8@976|Bacteroidetes,1HXHQ@117743|Flavobacteriia,3ZQ4A@59732|Chryseobacterium	976|Bacteroidetes	L	Subunit R is required for both nuclease and ATPase activities, but not for modification	hsdR	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF3387,HSDR_N,ResIII
SX3_k127_278344_11	1121468.AUBR01000009_gene2156	2.674e-60	220.0	COG2355@1|root,COG2355@2|Bacteria,1UA7M@1239|Firmicutes,24AE6@186801|Clostridia,42F00@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM Peptidase M19, renal dipeptidase	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
SX3_k127_278344_13	1027273.GZ77_15335	1.555e-52	202.0	COG0494@1|root,COG0494@2|Bacteria	2|Bacteria	L	nUDIX hydrolase	-	-	3.6.1.13,3.6.1.55	ko:K01515,ko:K03574	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF4743,NUDIX
SX3_k127_278344_17	697281.Mahau_0937	1.108e-10	69.0	COG3086@1|root,COG3086@2|Bacteria,1VEYP@1239|Firmicutes,24R8Z@186801|Clostridia	186801|Clostridia	T	PFAM Positive regulator of sigma(E) RseC MucC	-	-	-	ko:K03803	-	-	-	-	ko00000,ko03021	-	-	-	RseC_MucC
SX3_k127_278344_16	1499967.BAYZ01000095_gene4256	2.378e-23	116.0	COG5426@1|root,COG5426@2|Bacteria	2|Bacteria	D	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_278344_20	1499967.BAYZ01000095_gene4254	0.0001724	54.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	bztC	-	-	ko:K09971	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	-
SX3_k127_278344_5	1499967.BAYZ01000095_gene4253	2.163e-115	387.0	COG0714@1|root,COG0714@2|Bacteria,2NNV8@2323|unclassified Bacteria	2|Bacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
SX3_k127_278344_10	502025.Hoch_3262	1.434e-69	246.0	COG1721@1|root,COG1721@2|Bacteria,1NEAC@1224|Proteobacteria,43B78@68525|delta/epsilon subdivisions,2X6KP@28221|Deltaproteobacteria,2YWA8@29|Myxococcales	28221|Deltaproteobacteria	S	Von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
SX3_k127_278344_7	1499967.BAYZ01000095_gene4251	2.894e-92	330.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
SX3_k127_278344_3	1499967.BAYZ01000095_gene4241	3.321e-145	496.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	GATase1_like,VWA,VWA_2,VWA_3
SX3_k127_278344_12	697281.Mahau_1767	4.396e-58	210.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,248AR@186801|Clostridia,42EWH@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Ribulose-phosphate 3-epimerase	rpe	-	5.1.3.1	ko:K01783,ko:K17195	ko00030,ko00040,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529,R09031	RC00540,RC03111	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
SX3_k127_278344_4	1303518.CCALI_02349	2.023e-119	397.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
SX3_k127_278344_8	1343740.M271_42425	5.513e-91	314.0	COG1063@1|root,COG1063@2|Bacteria,2IDWX@201174|Actinobacteria	201174|Actinobacteria	E	Glucose dehydrogenase C-terminus	-	-	1.1.1.14,1.1.1.251	ko:K00008,ko:K00094	ko00040,ko00051,ko00052,ko01100,map00040,map00051,map00052,map01100	M00014	R00875,R01896,R05571	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
SX3_k127_278344_9	1499967.BAYZ01000050_gene2837	7.884e-85	296.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	iolE	-	4.2.1.44	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R02782,R05659	RC00782,RC01448	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
SX3_k127_278344_19	313628.LNTAR_12071	0.0001344	46.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
SX3_k127_278344_1	1304865.JAGF01000001_gene2487	6.835e-152	488.0	COG0673@1|root,COG0673@2|Bacteria,2GNEM@201174|Actinobacteria	201174|Actinobacteria	G	Oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
SX3_k127_278344_0	1195236.CTER_0372	1.239e-220	693.0	COG1486@1|root,COG1486@2|Bacteria,1TQ9I@1239|Firmicutes,24995@186801|Clostridia	186801|Clostridia	G	family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
SX3_k127_278344_15	530564.Psta_3643	8.627e-28	117.0	2C85M@1|root,32UAW@2|Bacteria,2J0CM@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Stress responsive A B Barrel Domain	-	-	-	-	-	-	-	-	-	-	-	-	Dabb
SX3_k127_278344_2	1487921.DP68_16700	6.552e-151	488.0	COG1902@1|root,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,24C9J@186801|Clostridia,36F9D@31979|Clostridiaceae	186801|Clostridia	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
SX3_k127_278344_18	1195236.CTER_0373	2.223e-09	60.0	COG2197@1|root,COG2202@1|root,COG2197@2|Bacteria,COG2202@2|Bacteria	2|Bacteria	T	Pas domain	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF,GAF_2,GerE,HATPase_c,HATPase_c_2,HisKA,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,STAS_2,Sigma70_r4_2,SpoIIE
SX3_k127_2786617_0	555079.Toce_1433	4.481e-109	371.0	COG4091@1|root,COG4091@2|Bacteria,1TR51@1239|Firmicutes,24AUF@186801|Clostridia,42I69@68295|Thermoanaerobacterales	186801|Clostridia	E	SAF domain	-	-	-	-	-	-	-	-	-	-	-	-	DapB_N,F420_oxidored,NAD_binding_3,SAF
SX3_k127_2786617_1	479434.Sthe_1759	1.412e-72	252.0	COG3958@1|root,COG3958@2|Bacteria,2G8E1@200795|Chloroflexi,27XY5@189775|Thermomicrobia	189775|Thermomicrobia	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
SX3_k127_2807045_28	1506583.JQJY01000001_gene411	1.893e-08	64.0	COG0642@1|root,COG0745@1|root,COG1879@1|root,COG0745@2|Bacteria,COG1879@2|Bacteria,COG2205@2|Bacteria,4NDXU@976|Bacteroidetes,1HXUN@117743|Flavobacteriia,2NUY8@237|Flavobacterium	976|Bacteroidetes	T	Periplasmic binding proteins and sugar binding domain of LacI family	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Peripla_BP_4,Response_reg
SX3_k127_2807045_25	445972.ANACOL_04122	4.02e-21	98.0	COG0346@1|root,COG0346@2|Bacteria,1VFT2@1239|Firmicutes,24R0F@186801|Clostridia	186801|Clostridia	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
SX3_k127_2807045_5	1122947.FR7_1360	1.641e-121	400.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes	1239|Firmicutes	E	Dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
SX3_k127_2807045_4	1122947.FR7_1359	7.478e-124	417.0	COG1082@1|root,COG1082@2|Bacteria,1TPJT@1239|Firmicutes	1239|Firmicutes	G	Xylose isomerase	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
SX3_k127_2807045_0	1499967.BAYZ01000067_gene6042	2.292e-201	640.0	COG1070@1|root,COG1070@2|Bacteria	2|Bacteria	G	xylulokinase activity	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
SX3_k127_2807045_12	1499967.BAYZ01000067_gene6041	2.754e-80	284.0	COG0274@1|root,COG0274@2|Bacteria,2NP8Z@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
SX3_k127_2807045_20	1235798.C817_03636	1.589e-52	196.0	COG2188@1|root,COG2188@2|Bacteria,1UYBW@1239|Firmicutes,24N1N@186801|Clostridia,27X94@189330|Dorea	186801|Clostridia	K	UTRA	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
SX3_k127_2807045_18	570967.JMLV01000011_gene3306	1.37e-63	225.0	COG1335@1|root,COG1335@2|Bacteria,1QK2B@1224|Proteobacteria,2U5X9@28211|Alphaproteobacteria,2JTV0@204441|Rhodospirillales	204441|Rhodospirillales	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
SX3_k127_2807045_3	1160707.AJIK01000036_gene2233	1.426e-130	433.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,4H9VK@91061|Bacilli	91061|Bacilli	G	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	rbsA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0006810,GO:0008144,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015146,GO:0015399,GO:0015405,GO:0015407,GO:0015591,GO:0015608,GO:0015611,GO:0015749,GO:0015750,GO:0015752,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034219,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043211,GO:0043492,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0097159,GO:0097367,GO:1901265,GO:1901363	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
SX3_k127_2807045_15	586413.CCDL010000001_gene710	1.114e-71	254.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,4H9Y3@91061|Bacilli,23KAP@182709|Oceanobacillus	91061|Bacilli	G	Branched-chain amino acid transport system / permease component	rbsC	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
SX3_k127_2807045_22	556261.HMPREF0240_03915	7.834e-46	179.0	COG1879@1|root,COG1879@2|Bacteria,1TQ1B@1239|Firmicutes,25BRG@186801|Clostridia,36GIU@31979|Clostridiaceae	186801|Clostridia	G	Periplasmic binding proteins and sugar binding domain of LacI family	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
SX3_k127_2807045_24	1907.SGLAU_04125	1.523e-26	123.0	COG0637@1|root,COG0637@2|Bacteria,2I362@201174|Actinobacteria	201174|Actinobacteria	S	hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
SX3_k127_2807045_14	573413.Spirs_1013	1.096e-71	254.0	COG2114@1|root,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Guanylate_cyc
SX3_k127_2807045_13	556261.HMPREF0240_00555	6.122e-79	277.0	COG0407@1|root,COG0407@2|Bacteria,1URPV@1239|Firmicutes,24XIW@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_2807045_19	264732.Moth_1212	1.959e-63	221.0	COG0778@1|root,COG0778@2|Bacteria,1V4DP@1239|Firmicutes,24HBZ@186801|Clostridia,42J1R@68295|Thermoanaerobacterales	186801|Clostridia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SX3_k127_2807045_9	1499967.BAYZ01000163_gene6599	7.207e-95	324.0	COG0407@1|root,COG0407@2|Bacteria,2NRD5@2323|unclassified Bacteria	2|Bacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
SX3_k127_2807045_23	452637.Oter_2886	5.781e-44	173.0	COG0407@1|root,COG0407@2|Bacteria,46WW7@74201|Verrucomicrobia,3K8TQ@414999|Opitutae	414999|Opitutae	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
SX3_k127_2807045_6	1499967.BAYZ01000057_gene4680	1.235e-106	364.0	COG1070@1|root,COG1070@2|Bacteria	2|Bacteria	G	xylulokinase activity	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
SX3_k127_2807045_8	1499967.BAYZ01000012_gene2472	2.835e-95	324.0	COG1879@1|root,COG1879@2|Bacteria	2|Bacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K10439,ko:K10440	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
SX3_k127_2807045_1	697281.Mahau_0119	5.327e-161	523.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,42EK6@68295|Thermoanaerobacterales	186801|Clostridia	P	Part of an ABC transporter complex involved in carbohydrate import. Could be involved in ribose, galactose and or methyl galactoside import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
SX3_k127_2807045_10	632292.Calhy_0487	6.471e-94	319.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,249FA@186801|Clostridia,42FP3@68295|Thermoanaerobacterales	186801|Clostridia	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
SX3_k127_2807045_11	794846.AJQU01000131_gene3830	1.68e-91	312.0	COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,2TV15@28211|Alphaproteobacteria,4BAK3@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Ribose xylose arabinose galactoside ABC-type transport systems, permease components	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
SX3_k127_2807045_17	428125.CLOLEP_00196	1.382e-68	246.0	COG2390@1|root,COG2390@2|Bacteria,1TPUB@1239|Firmicutes,25D2S@186801|Clostridia,3WM1M@541000|Ruminococcaceae	186801|Clostridia	K	Putative sugar-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,Sigma70_r4,Sugar-bind
SX3_k127_2807045_21	1499967.BAYZ01000022_gene247	3.13e-49	183.0	COG1461@1|root,COG1461@2|Bacteria	2|Bacteria	S	glycerone kinase activity	-	-	2.7.1.121	ko:K05879	ko00561,ko01100,map00561,map01100	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000	-	-	-	Dak2
SX3_k127_2807045_2	1499967.BAYZ01000022_gene246	3.3e-153	491.0	COG2376@1|root,COG2376@2|Bacteria,2NQCP@2323|unclassified Bacteria	2|Bacteria	G	Dak1 domain	-	-	2.7.1.121,2.7.1.28,2.7.1.29,4.6.1.15	ko:K00863,ko:K05878,ko:K05879	ko00051,ko00561,ko00680,ko01100,ko01120,ko01200,ko04622,map00051,map00561,map00680,map01100,map01120,map01200,map04622	M00344	R01011,R01012,R01059	RC00002,RC00015,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Dak1,Dak2
SX3_k127_2807045_16	573413.Spirs_0305	1.612e-70	246.0	COG0269@1|root,COG0269@2|Bacteria,2JBBM@203691|Spirochaetes	203691|Spirochaetes	G	Orotidine 5'-phosphate decarboxylase / HUMPS family	-	-	4.1.1.85	ko:K03078	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R07125	RC01721	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
SX3_k127_2807045_7	1499967.BAYZ01000057_gene4680	4.18e-105	362.0	COG1070@1|root,COG1070@2|Bacteria	2|Bacteria	G	xylulokinase activity	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
SX3_k127_2807045_26	1121335.Clst_0441	2.009e-13	81.0	2CEJC@1|root,32R1S@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2807045_27	203119.Cthe_0231	4.05e-10	62.0	COG0535@1|root,COG0535@2|Bacteria,1TR52@1239|Firmicutes,247SB@186801|Clostridia,3WK9K@541000|Ruminococcaceae	186801|Clostridia	C	Radical SAM domain protein	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,PqqD,Radical_SAM,SPASM
SX3_k127_281143_2	744872.Spica_1832	7.393e-148	478.0	COG0342@1|root,COG0342@2|Bacteria,2J5UV@203691|Spirochaetes	203691|Spirochaetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
SX3_k127_281143_4	1123274.KB899433_gene1343	1.575e-71	269.0	COG0341@1|root,COG0341@2|Bacteria,2J5N7@203691|Spirochaetes	203691|Spirochaetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
SX3_k127_281143_5	342949.PNA2_0923	2.485e-45	173.0	COG2129@1|root,arCOG01145@2157|Archaea,2XW7S@28890|Euryarchaeota,242PU@183968|Thermococci	183968|Thermococci	S	Metallophosphoesterase, calcineurin superfamily	-	-	-	ko:K07096	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
SX3_k127_281143_1	665571.STHERM_c01340	5.666e-249	802.0	COG0021@1|root,COG0021@2|Bacteria,2J6KB@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
SX3_k127_281143_8	2880.D7FH03	7.77e-31	138.0	COG0707@1|root,2QPXV@2759|Eukaryota	2759|Eukaryota	M	1,2-diacylglycerol 3-beta-galactosyltransferase activity	MGD1	GO:0000003,GO:0003006,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006643,GO:0006664,GO:0006950,GO:0006996,GO:0007154,GO:0007275,GO:0008150,GO:0008152,GO:0008194,GO:0008378,GO:0008610,GO:0009058,GO:0009247,GO:0009267,GO:0009507,GO:0009526,GO:0009527,GO:0009528,GO:0009536,GO:0009605,GO:0009657,GO:0009668,GO:0009706,GO:0009707,GO:0009790,GO:0009791,GO:0009793,GO:0009941,GO:0009987,GO:0009991,GO:0010027,GO:0010154,GO:0016020,GO:0016036,GO:0016043,GO:0016740,GO:0016757,GO:0016758,GO:0019374,GO:0019752,GO:0019866,GO:0019867,GO:0022414,GO:0031090,GO:0031667,GO:0031668,GO:0031669,GO:0031967,GO:0031968,GO:0031969,GO:0031975,GO:0032501,GO:0032502,GO:0032787,GO:0033554,GO:0035250,GO:0042170,GO:0042594,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046467,GO:0046509,GO:0048316,GO:0048608,GO:0048731,GO:0048856,GO:0050896,GO:0051716,GO:0061024,GO:0061458,GO:0071496,GO:0071704,GO:0071840,GO:0098588,GO:0098805,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.46	ko:K03715	ko00561,ko01100,map00561,map01100	-	R02691	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT28	-	Glyco_tran_28_C,MGDG_synth
SX3_k127_281143_0	665571.STHERM_c16030	8.52e-268	835.0	COG0441@1|root,COG0441@2|Bacteria,2J5ID@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
SX3_k127_281143_3	945713.IALB_0134	1.57e-127	421.0	COG0572@1|root,COG0572@2|Bacteria	2|Bacteria	F	uridine kinase	udk	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
SX3_k127_281143_7	744872.Spica_0441	7.357e-32	136.0	COG0558@1|root,COG0558@2|Bacteria,2J7BV@203691|Spirochaetes	203691|Spirochaetes	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
SX3_k127_281143_6	573413.Spirs_3225	7.019e-32	131.0	COG0558@1|root,COG0558@2|Bacteria,2J7NA@203691|Spirochaetes	203691|Spirochaetes	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
SX3_k127_281413_11	573413.Spirs_1891	2.54e-55	196.0	COG1344@1|root,COG1344@2|Bacteria,2J5TJ@203691|Spirochaetes	203691|Spirochaetes	N	Component of the core of the flagella	-	-	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
SX3_k127_281413_4	744872.Spica_0674	6.774e-91	312.0	COG0457@1|root,COG0457@2|Bacteria,2J5UY@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_7,TPR_8
SX3_k127_281413_8	889378.Spiaf_0808	1.421e-74	260.0	2920H@1|root,2ZPJT@2|Bacteria,2J5PN@203691|Spirochaetes	203691|Spirochaetes	S	Pilus assembly protein PilZ	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
SX3_k127_281413_12	889378.Spiaf_0809	3.141e-54	203.0	COG0524@1|root,COG0524@2|Bacteria	2|Bacteria	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	pfkB	-	2.7.1.15,2.7.1.4	ko:K00847,ko:K00852	ko00030,ko00051,ko00500,ko00520,ko01100,map00030,map00051,map00500,map00520,map01100	-	R00760,R00867,R01051,R02750,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
SX3_k127_281413_3	1185652.USDA257_c02800	2.847e-107	372.0	COG1172@1|root,COG1172@2|Bacteria,1MV4F@1224|Proteobacteria,2TT2T@28211|Alphaproteobacteria,4BBDD@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Belongs to the binding-protein-dependent transport system permease family	rhaQ	-	-	ko:K10561	ko02010,map02010	M00220	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.9	-	-	BPD_transp_2
SX3_k127_281413_0	760011.Spico_1658	9.896e-183	584.0	COG1129@1|root,COG1129@2|Bacteria,2J6Z7@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10562	ko02010,map02010	M00220	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.9	-	-	ABC_tran
SX3_k127_281413_2	665571.STHERM_c08320	9.219e-133	438.0	COG1879@1|root,COG1879@2|Bacteria,2J7XC@203691|Spirochaetes	203691|Spirochaetes	G	TIGRFAM rhamnose ABC transporter, rhamnose-binding	-	-	-	ko:K10559	ko02010,map02010	M00220	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.9	-	-	Peripla_BP_4
SX3_k127_281413_7	1121346.KB899833_gene825	5.184e-77	278.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V26B@1239|Firmicutes,4HUX5@91061|Bacilli,26WZG@186822|Paenibacillaceae	91061|Bacilli	T	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,Response_reg
SX3_k127_281413_6	665571.STHERM_c08300	1.177e-81	297.0	COG2972@1|root,COG2972@2|Bacteria,2J80B@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,His_kinase
SX3_k127_281413_22	1379698.RBG1_1C00001G1122	6.305e-07	55.0	COG3027@1|root,COG3027@2|Bacteria,2NQ5R@2323|unclassified Bacteria	2|Bacteria	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	zapA	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
SX3_k127_281413_21	545695.TREAZ_0922	1.296e-08	67.0	28ZFQ@1|root,2ZM78@2|Bacteria,2J8CS@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ZapB
SX3_k127_281413_14	573413.Spirs_2592	3.554e-38	146.0	COG0292@1|root,COG0292@2|Bacteria,2J82V@203691|Spirochaetes	203691|Spirochaetes	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
SX3_k127_281413_18	889378.Spiaf_0813	2.164e-22	97.0	COG0291@1|root,COG0291@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
SX3_k127_281413_10	665571.STHERM_c07810	5.495e-71	244.0	COG0290@1|root,COG0290@2|Bacteria,2J76T@203691|Spirochaetes	203691|Spirochaetes	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
SX3_k127_281413_19	398525.KB900701_gene2815	5.891e-18	100.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,3JR8W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
SX3_k127_281413_20	1173025.GEI7407_3496	7.124e-16	90.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria,1H8AZ@1150|Oscillatoriales	1117|Cyanobacteria	L	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
SX3_k127_281413_9	907348.TresaDRAFT_2409	3.416e-74	256.0	COG0563@1|root,COG0563@2|Bacteria,2J6MV@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
SX3_k127_281413_1	1191523.MROS_1378	6.286e-182	578.0	COG0499@1|root,COG0499@2|Bacteria	2|Bacteria	H	adenosylhomocysteinase activity	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
SX3_k127_281413_5	443143.GM18_1260	6.273e-83	302.0	COG4251@1|root,COG4936@1|root,COG5000@1|root,COG4251@2|Bacteria,COG4936@2|Bacteria,COG5000@2|Bacteria,1NSQ1@1224|Proteobacteria,42QPS@68525|delta/epsilon subdivisions,2WMWT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HATPase_c,HisKA,PAS_4,PAS_8,PAS_9,dCache_1
SX3_k127_281413_17	443143.GM18_2824	5.46e-27	123.0	COG0834@1|root,COG4191@1|root,COG4936@1|root,COG0834@2|Bacteria,COG4191@2|Bacteria,COG4936@2|Bacteria,1RCM9@1224|Proteobacteria,42PH8@68525|delta/epsilon subdivisions,2WKUF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,PocR,Response_reg
SX3_k127_281413_16	1221522.B723_00815	3.149e-28	133.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RQIN@1236|Gammaproteobacteria,1YQ08@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	T	Cache domain	dctB	-	2.7.13.3	ko:K10125	ko02020,map02020	M00504	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,dCache_1
SX3_k127_281413_13	1173026.Glo7428_2204	1.243e-52	188.0	COG0784@1|root,COG0784@2|Bacteria,1GQ4W@1117|Cyanobacteria	1117|Cyanobacteria	T	PFAM response regulator receiveR	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
SX3_k127_281413_15	1123508.JH636440_gene2608	1.314e-29	123.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,HATPase_c,HisKA,PAS_9,Response_reg
SX3_k127_2819245_1	1487923.DP73_14320	1.401e-78	279.0	COG1835@1|root,COG1835@2|Bacteria,1V7CG@1239|Firmicutes,24WKR@186801|Clostridia,263B9@186807|Peptococcaceae	186801|Clostridia	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
SX3_k127_2819245_3	1480694.DC28_09205	3.422e-49	183.0	COG0170@1|root,COG0170@2|Bacteria,2J6YY@203691|Spirochaetes	203691|Spirochaetes	I	Phosphatidate cytidylyltransferase	cdsA_1	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2819245_4	871968.DESME_04290	1.544e-19	96.0	COG1233@1|root,COG1233@2|Bacteria,1TS4A@1239|Firmicutes,249K1@186801|Clostridia,2633J@186807|Peptococcaceae	186801|Clostridia	Q	amine oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
SX3_k127_2819245_0	926550.CLDAP_40700	8.582e-79	282.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
SX3_k127_2819245_2	1499967.BAYZ01000067_gene6044	3.98e-67	239.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	ko:K02025,ko:K15771	ko02010,map02010	M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
SX3_k127_2819245_5	1041146.ATZB01000011_gene951	4.501e-12	71.0	COG0395@1|root,COG0395@2|Bacteria,1MXEM@1224|Proteobacteria,2TUQV@28211|Alphaproteobacteria,4BBEJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	ycjP	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX3_k127_289685_7	1499967.BAYZ01000164_gene6663	1.047e-174	554.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_289685_0	243231.GSU2758	0.0	2505.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42P3V@68525|delta/epsilon subdivisions,2WKWV@28221|Deltaproteobacteria,43TF0@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA1	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
SX3_k127_289685_38	643648.Slip_0169	1.044e-50	202.0	COG1368@1|root,COG1368@2|Bacteria,1V8EX@1239|Firmicutes,24KF8@186801|Clostridia	186801|Clostridia	M	CytoplasmicMembrane, score 9.99	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
SX3_k127_289685_12	886293.Sinac_7570	2.855e-137	451.0	COG2242@1|root,COG2242@2|Bacteria,2J25Y@203682|Planctomycetes	203682|Planctomycetes	H	protein methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_289685_33	545694.TREPR_2780	7.222e-61	236.0	COG0457@1|root,COG1652@1|root,COG0457@2|Bacteria,COG1652@2|Bacteria,2J7YH@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_289685_9	926550.CLDAP_34170	1.386e-158	508.0	COG1840@1|root,COG1840@2|Bacteria,2G5QA@200795|Chloroflexi	200795|Chloroflexi	P	extracellular solute-binding protein, family 1	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
SX3_k127_289685_5	926550.CLDAP_34180	4.219e-208	672.0	COG1178@1|root,COG1178@2|Bacteria	2|Bacteria	P	thiamine transport	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
SX3_k127_289685_17	926550.CLDAP_34190	3.065e-119	394.0	COG3842@1|root,COG3842@2|Bacteria,2G5JJ@200795|Chloroflexi	200795|Chloroflexi	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	3.6.3.30	ko:K02010,ko:K02052	ko02010,ko02024,map02010,map02024	M00190,M00193	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10,3.A.1.11	-	-	ABC_tran,TOBE_2
SX3_k127_289685_14	665571.STHERM_c18190	2.563e-131	428.0	COG0673@1|root,COG0673@2|Bacteria,2J5J5@203691|Spirochaetes	203691|Spirochaetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
SX3_k127_289685_2	1347392.CCEZ01000043_gene111	1.823e-271	862.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia,36DY8@31979|Clostridiaceae	186801|Clostridia	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
SX3_k127_289685_25	1304865.JAGF01000001_gene1578	3.331e-88	304.0	28PJ3@1|root,2ZC8W@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_289685_35	316067.Geob_2141	3.204e-54	201.0	COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,42MFI@68525|delta/epsilon subdivisions,2WKXD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
SX3_k127_289685_47	313628.LNTAR_03204	4.355e-12	72.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
SX3_k127_289685_45	557599.MKAN_09185	1.606e-17	87.0	COG1487@1|root,COG1487@2|Bacteria,2GYEI@201174|Actinobacteria,23DTM@1762|Mycobacteriaceae	201174|Actinobacteria	S	PIN domain	-	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
SX3_k127_289685_48	1299327.I546_3204	2.801e-09	62.0	2B9IU@1|root,322WZ@2|Bacteria,2H7E4@201174|Actinobacteria,23E68@1762|Mycobacteriaceae	201174|Actinobacteria	S	Putative antitoxin	-	-	-	-	-	-	-	-	-	-	-	-	VAPB_antitox
SX3_k127_289685_4	158190.SpiGrapes_2655	1.338e-239	752.0	COG0488@1|root,COG0488@2|Bacteria,2JA3A@203691|Spirochaetes	203691|Spirochaetes	S	ATPase component of ABC transporters with duplicated ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
SX3_k127_289685_40	1191523.MROS_1409	2.211e-47	181.0	COG0642@1|root,COG3275@1|root,COG2205@2|Bacteria,COG3275@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.7.7.65	ko:K18967	-	-	-	-	ko00000,ko01000,ko02000	9.B.34.1.1	-	-	5TM-5TMR_LYT,GGDEF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_7,PAS_9,Response_reg
SX3_k127_289685_11	96561.Dole_3272	8.922e-144	484.0	COG0784@1|root,COG2202@1|root,COG3437@1|root,COG3829@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3437@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria,2MI5F@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3
SX3_k127_289685_1	641491.DND132_1005	2.44e-272	850.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,42M3S@68525|delta/epsilon subdivisions,2WJVZ@28221|Deltaproteobacteria,2M885@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	elongation factor Tu domain 2 protein	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
SX3_k127_289685_8	1489678.RDMS_01965	8.196e-164	535.0	COG0514@1|root,COG0514@2|Bacteria	2|Bacteria	L	ATP-dependent DNA helicase (RecQ)	recQ	GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008270,GO:0009295,GO:0009378,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0017117,GO:0030894,GO:0032392,GO:0032508,GO:0032991,GO:0032993,GO:0033202,GO:0033554,GO:0034641,GO:0042623,GO:0043138,GO:0043140,GO:0043142,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1904949	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind
SX3_k127_289685_13	1304888.ATWF01000001_gene916	1.304e-133	446.0	COG0488@1|root,COG0488@2|Bacteria,2GF1Z@200930|Deferribacteres	200930|Deferribacteres	S	ABC transporter	-	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
SX3_k127_289685_10	237368.SCABRO_02068	2.437e-149	491.0	COG0513@1|root,COG0513@2|Bacteria,2IX02@203682|Planctomycetes	203682|Planctomycetes	JKL	DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation	deaD	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
SX3_k127_289685_32	452637.Oter_3739	8.104e-66	233.0	COG3148@1|root,COG3148@2|Bacteria,46VF1@74201|Verrucomicrobia,3K7WX@414999|Opitutae	414999|Opitutae	S	DTW	-	-	-	-	-	-	-	-	-	-	-	-	DTW
SX3_k127_289685_3	545695.TREAZ_2692	1.749e-243	764.0	COG0488@1|root,COG0488@2|Bacteria,2J5P1@203691|Spirochaetes	203691|Spirochaetes	S	ABC transporter, ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
SX3_k127_289685_37	744872.Spica_2052	3.379e-53	195.0	COG2095@1|root,COG2095@2|Bacteria,2J7MT@203691|Spirochaetes	203691|Spirochaetes	U	membrane	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
SX3_k127_289685_39	383372.Rcas_2834	4.35e-48	175.0	COG4154@1|root,COG4154@2|Bacteria	2|Bacteria	G	fucose binding	fucU	-	5.1.3.29	ko:K02431	-	-	R10764	RC00563	ko00000,ko01000	-	-	-	RbsD_FucU
SX3_k127_289685_6	1122962.AULH01000015_gene756	7.999e-182	576.0	COG1482@1|root,COG1482@2|Bacteria	2|Bacteria	G	cell wall glycoprotein biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_289685_21	1499967.BAYZ01000059_gene4789	4.401e-103	349.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_289685_27	1449065.JMLL01000012_gene3521	1.815e-84	287.0	COG1129@1|root,COG1129@2|Bacteria,1MW4I@1224|Proteobacteria,2UP9P@28211|Alphaproteobacteria,43MS6@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
SX3_k127_289685_23	990285.RGCCGE502_11551	2.021e-93	318.0	COG1172@1|root,COG1172@2|Bacteria,1MUDF@1224|Proteobacteria,2TS7T@28211|Alphaproteobacteria,4BD4A@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
SX3_k127_289685_34	1246459.KB898371_gene50	8.705e-58	213.0	COG1879@1|root,COG1879@2|Bacteria,1N64A@1224|Proteobacteria,2UQM0@28211|Alphaproteobacteria,4BNFH@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Periplasmic binding protein domain	-	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Peripla_BP_4
SX3_k127_289685_18	1499967.BAYZ01000119_gene3205	2.004e-111	368.0	COG1609@1|root,COG1609@2|Bacteria,2NPGW@2323|unclassified Bacteria	2|Bacteria	K	PFAM Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
SX3_k127_289685_22	641524.ADICYQ_2925	2.026e-98	334.0	COG0673@1|root,COG0673@2|Bacteria,4NFY3@976|Bacteroidetes,47ME7@768503|Cytophagia	976|Bacteroidetes	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX3_k127_289685_26	1535287.JP74_10990	7.759e-86	304.0	COG0600@1|root,COG0600@2|Bacteria,1R3V5@1224|Proteobacteria,2TSG0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system permease component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
SX3_k127_289685_30	1380394.JADL01000001_gene2547	6.708e-70	245.0	COG1116@1|root,COG1116@2|Bacteria,1MUIM@1224|Proteobacteria,2TRHM@28211|Alphaproteobacteria,2JW7Z@204441|Rhodospirillales	204441|Rhodospirillales	P	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
SX3_k127_289685_28	1122132.AQYH01000003_gene3187	3.403e-80	283.0	COG0715@1|root,COG0715@2|Bacteria,1NYKG@1224|Proteobacteria,2TTTW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
SX3_k127_289685_19	344747.PM8797T_03174	9.056e-107	360.0	COG0673@1|root,COG0673@2|Bacteria,2IYW6@203682|Planctomycetes	203682|Planctomycetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA
SX3_k127_289685_36	411470.RUMGNA_03031	5.515e-54	204.0	COG0006@1|root,COG0006@2|Bacteria,1VS27@1239|Firmicutes,24A4K@186801|Clostridia	186801|Clostridia	E	Creatinase/Prolidase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
SX3_k127_289685_29	1033743.CAES01000004_gene2143	3.388e-76	272.0	COG0624@1|root,COG0624@2|Bacteria,1TQS9@1239|Firmicutes,4HDHW@91061|Bacilli,26UDI@186822|Paenibacillaceae	91061|Bacilli	E	Peptidase family M20/M25/M40	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
SX3_k127_289685_44	944481.JAFP01000001_gene932	3.507e-18	95.0	COG0697@1|root,COG0697@2|Bacteria,1NS7A@1224|Proteobacteria,42MCJ@68525|delta/epsilon subdivisions,2WKQ4@28221|Deltaproteobacteria,2M73M@213113|Desulfurellales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SX3_k127_289685_15	326427.Cagg_1321	5.683e-129	432.0	COG1574@1|root,COG1574@2|Bacteria,2G5YJ@200795|Chloroflexi,375CQ@32061|Chloroflexia	32061|Chloroflexia	S	PFAM Amidohydrolase 3	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
SX3_k127_289685_24	1278073.MYSTI_04190	1.275e-91	314.0	COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,42PYX@68525|delta/epsilon subdivisions,2WKSE@28221|Deltaproteobacteria,2YUVH@29|Myxococcales	28221|Deltaproteobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_289685_20	929703.KE386491_gene1241	5.25e-104	344.0	COG3384@1|root,COG3384@2|Bacteria,4NFGT@976|Bacteroidetes,47KW5@768503|Cytophagia	976|Bacteroidetes	S	PFAM Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
SX3_k127_289685_49	395961.Cyan7425_1350	8.204e-09	57.0	COG1724@1|root,COG1724@2|Bacteria,1GKSW@1117|Cyanobacteria,3KIQE@43988|Cyanothece	1117|Cyanobacteria	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
SX3_k127_289685_43	593750.Metfor_1990	2.215e-20	93.0	COG1598@1|root,arCOG02412@2157|Archaea,2Y1KY@28890|Euryarchaeota,2NB5X@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_289685_16	1499967.BAYZ01000163_gene6585	8.333e-120	389.0	COG2189@1|root,COG2189@2|Bacteria,2NP0F@2323|unclassified Bacteria	2|Bacteria	L	PFAM DNA methylase N-4 N-6	-	-	2.1.1.72	ko:K07316	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
SX3_k127_289685_31	179408.Osc7112_4330	2.639e-69	238.0	COG2189@1|root,COG2189@2|Bacteria,1G0NR@1117|Cyanobacteria,1H91K@1150|Oscillatoriales	1117|Cyanobacteria	L	DNA methylase	-	-	2.1.1.72	ko:K07316	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
SX3_k127_2906097_5	665571.STHERM_c04560	1.259e-22	102.0	COG0568@1|root,COG0568@2|Bacteria,2J5M9@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086,ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
SX3_k127_2906097_2	1220534.B655_1767	5.063e-128	425.0	COG2327@1|root,arCOG04826@2157|Archaea	2157|Archaea	S	PFAM Polysaccharide pyruvyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	PS_pyruv_trans
SX3_k127_2906097_0	509191.AEDB02000076_gene1445	2.167e-274	884.0	COG1022@1|root,COG3320@1|root,COG1022@2|Bacteria,COG3320@2|Bacteria,1UVSP@1239|Firmicutes,24XTK@186801|Clostridia	186801|Clostridia	I	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
SX3_k127_2906097_4	1131462.DCF50_p2424	5.01e-28	124.0	2DQ4Q@1|root,334QV@2|Bacteria,1VVNN@1239|Firmicutes,2513M@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2906097_1	1131462.DCF50_p2423	9.01e-150	488.0	COG2303@1|root,COG2303@2|Bacteria,1V115@1239|Firmicutes,24FDE@186801|Clostridia,263C0@186807|Peptococcaceae	186801|Clostridia	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
SX3_k127_2906097_3	1265313.HRUBRA_01348	3.697e-81	291.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
SX3_k127_3032513_0	573413.Spirs_0261	8.085e-188	594.0	COG0442@1|root,COG0442@2|Bacteria,2J5HF@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
SX3_k127_3032513_13	204669.Acid345_3570	8.845e-51	191.0	COG1131@1|root,COG1131@2|Bacteria,3Y394@57723|Acidobacteria,2JINE@204432|Acidobacteriia	204432|Acidobacteriia	V	pfam abc	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_3032513_12	1123274.KB899407_gene244	8.184e-54	196.0	COG5497@1|root,COG5497@2|Bacteria,2J7E8@203691|Spirochaetes	203691|Spirochaetes	S	Predicted secreted protein (DUF2259)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2259
SX3_k127_3032513_6	1120973.AQXL01000129_gene2466	2.128e-114	377.0	COG2876@1|root,COG2876@2|Bacteria,1TP61@1239|Firmicutes,4HB03@91061|Bacilli,2781M@186823|Alicyclobacillaceae	91061|Bacilli	E	NeuB family	aroF	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
SX3_k127_3032513_21	573413.Spirs_0258	3.906e-06	58.0	290XW@1|root,2ZNJN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3032513_14	1480694.DC28_09205	8.771e-49	182.0	COG0170@1|root,COG0170@2|Bacteria,2J6YY@203691|Spirochaetes	203691|Spirochaetes	I	Phosphatidate cytidylyltransferase	cdsA_1	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3032513_10	1262449.CP6013_0475	1.508e-81	288.0	COG1835@1|root,COG1835@2|Bacteria,1V7CG@1239|Firmicutes,24WKR@186801|Clostridia	186801|Clostridia	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
SX3_k127_3032513_22	1125863.JAFN01000001_gene824	0.0001812	47.0	COG3177@1|root,COG3177@2|Bacteria,1MV69@1224|Proteobacteria,42MWV@68525|delta/epsilon subdivisions,2WJJZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	filamentation induced by cAMP protein Fic	-	-	-	-	-	-	-	-	-	-	-	-	Fic,Fic_N,HTH_24
SX3_k127_3032513_3	278957.ABEA03000060_gene3064	1.749e-148	486.0	COG0421@1|root,COG0421@2|Bacteria,46Z5G@74201|Verrucomicrobia,3K91M@414999|Opitutae	414999|Opitutae	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3032513_19	158190.SpiGrapes_2237	1.423e-11	77.0	COG2197@1|root,COG2197@2|Bacteria,2J9AC@203691|Spirochaetes	203691|Spirochaetes	KT	transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE
SX3_k127_3032513_4	367737.Abu_0613	5.138e-136	443.0	COG0694@1|root,COG0822@1|root,COG0694@2|Bacteria,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,42MT6@68525|delta/epsilon subdivisions,2YMXY@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	CO	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins	iscU	-	-	ko:K13819	-	-	-	-	ko00000	-	-	-	Fer2_BFD,NifU,NifU_N
SX3_k127_3032513_2	118005.AWNK01000006_gene1380	2.417e-169	539.0	COG1104@1|root,COG1104@2|Bacteria	2|Bacteria	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	nifS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
SX3_k127_3032513_5	665571.STHERM_c00350	4.984e-119	391.0	COG0682@1|root,COG0682@2|Bacteria,2J58I@203691|Spirochaetes	203691|Spirochaetes	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
SX3_k127_3032513_1	1123274.KB899407_gene345	1.031e-187	621.0	COG1315@1|root,COG1315@2|Bacteria,2J5P2@203691|Spirochaetes	203691|Spirochaetes	L	PALM domain HD hydrolase domain and	-	-	-	ko:K09749	-	-	-	-	ko00000	-	-	-	FapA
SX3_k127_3032513_16	573413.Spirs_1833	2.264e-45	186.0	COG0785@1|root,COG0785@2|Bacteria,2JA8R@203691|Spirochaetes	203691|Spirochaetes	O	Cytochrome C biogenesis protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3032513_8	1123274.KB899407_gene346	5.164e-100	342.0	COG0455@1|root,COG0455@2|Bacteria,2J5K5@203691|Spirochaetes	203691|Spirochaetes	D	ATP-binding protein	ylxH-2	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	CbiA,ParA
SX3_k127_3032513_7	889378.Spiaf_2778	1.937e-111	376.0	COG0793@1|root,COG0793@2|Bacteria,2J5QD@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the peptidase S41A family	ctp	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
SX3_k127_3032513_17	545695.TREAZ_2709	2.911e-32	143.0	COG1385@1|root,COG1385@2|Bacteria,2J7WH@203691|Spirochaetes	203691|Spirochaetes	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
SX3_k127_3032513_15	573413.Spirs_0150	9.881e-48	183.0	COG1922@1|root,COG1922@2|Bacteria,2J6M5@203691|Spirochaetes	203691|Spirochaetes	M	WecB TagA CpsF family	-	-	2.4.1.187	ko:K05946	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB
SX3_k127_3032513_18	889378.Spiaf_2775	1.471e-23	108.0	COG3030@1|root,COG3030@2|Bacteria	2|Bacteria	S	protein affecting phage T7 exclusion by the F plasmid	fxsA	-	2.3.3.13	ko:K01649,ko:K07113	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	FxsA
SX3_k127_3032513_9	1340493.JNIF01000003_gene4239	7.364e-93	317.0	COG2204@1|root,COG2204@2|Bacteria,3Y38J@57723|Acidobacteria	57723|Acidobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
SX3_k127_3032513_11	1123274.KB899422_gene107	9.691e-68	239.0	COG0565@1|root,COG0565@2|Bacteria,2J6NV@203691|Spirochaetes	203691|Spirochaetes	J	RNA methyltransferase TrmH family	trmJ	-	2.1.1.200	ko:K02533,ko:K15396	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
SX3_k127_308127_3	794903.OPIT5_18780	1.318e-11	67.0	COG1624@1|root,COG1762@1|root,COG1624@2|Bacteria,COG1762@2|Bacteria,46TVS@74201|Verrucomicrobia,3K7HC@414999|Opitutae	414999|Opitutae	H	Diadenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	DisA_N,PTS_EIIA_2
SX3_k127_308127_0	428125.CLOLEP_01849	5.335e-105	359.0	COG0191@1|root,COG0191@2|Bacteria,1TQ01@1239|Firmicutes,248B7@186801|Clostridia,3WHFM@541000|Ruminococcaceae	186801|Clostridia	G	COG COG0191 Fructose tagatose bisphosphate aldolase	-	-	4.1.2.13,4.1.2.40	ko:K01624,ko:K08302	ko00010,ko00030,ko00051,ko00052,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01069,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
SX3_k127_308127_1	1235798.C817_05435	1.084e-88	302.0	COG0524@1|root,COG0524@2|Bacteria,1UYF8@1239|Firmicutes,24CAQ@186801|Clostridia,27W2K@189330|Dorea	186801|Clostridia	G	Phosphomethylpyrimidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
SX3_k127_308127_2	1123228.AUIH01000010_gene4000	1.108e-24	106.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,1RP3G@1236|Gammaproteobacteria,1XHJM@135619|Oceanospirillales	135619|Oceanospirillales	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit	bkdA2	-	1.2.4.4	ko:K00167	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
SX3_k127_3090817_17	1499967.BAYZ01000032_gene1138	4.695e-10	60.0	COG2407@1|root,COG2407@2|Bacteria	2|Bacteria	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	Fucose_iso_C
SX3_k127_3090817_7	665571.STHERM_c02560	3.147e-111	384.0	COG2017@1|root,COG2017@2|Bacteria,2J5MM@203691|Spirochaetes	203691|Spirochaetes	G	Converts alpha-aldose to the beta-anomer	galM	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
SX3_k127_3090817_4	584708.Apau_0592	2.059e-180	575.0	COG0017@1|root,COG0017@2|Bacteria,3T9TP@508458|Synergistetes	508458|Synergistetes	J	PFAM tRNA synthetase class II (D K and N)	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
SX3_k127_3090817_14	573413.Spirs_3148	1.661e-63	237.0	COG1536@1|root,COG1536@2|Bacteria,2J6EK@203691|Spirochaetes	203691|Spirochaetes	N	flagellar motor switch protein	fliG-1	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
SX3_k127_3090817_15	744872.Spica_0860	3.3e-49	195.0	2DBQ8@1|root,2ZACX@2|Bacteria,2J648@203691|Spirochaetes	203691|Spirochaetes	S	Zinc dependent phospholipase C	-	-	-	-	-	-	-	-	-	-	-	-	Zn_dep_PLPC
SX3_k127_3090817_6	926569.ANT_14910	2.351e-138	452.0	COG0153@1|root,COG0153@2|Bacteria,2G6CE@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the GHMP kinase family. GalK subfamily	galK	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
SX3_k127_3090817_20	509191.AEDB02000003_gene1019	0.0008996	43.0	2DPV4@1|root,333HA@2|Bacteria,1VH7Z@1239|Firmicutes,24SC2@186801|Clostridia,3WQ8C@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3090817_2	867903.ThesuDRAFT_01230	3.359e-192	611.0	COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,2493W@186801|Clostridia,3WCWS@538999|Clostridiales incertae sedis	186801|Clostridia	H	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
SX3_k127_3090817_16	744872.Spica_1482	9.38e-20	100.0	290DX@1|root,32INT@2|Bacteria,2J83J@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3090817_5	573413.Spirs_0100	1.461e-150	486.0	COG1435@1|root,COG1435@2|Bacteria,2J6SK@203691|Spirochaetes	203691|Spirochaetes	F	thymidine kinase	tdk	-	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TK
SX3_k127_3090817_11	1499967.BAYZ01000123_gene2487	4.692e-90	306.0	COG1349@1|root,COG1349@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K03436	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
SX3_k127_3090817_0	1499967.BAYZ01000032_gene1135	2.852e-200	636.0	COG4992@1|root,COG4992@2|Bacteria	2|Bacteria	E	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity	-	-	2.6.1.11,2.6.1.17,2.6.1.82	ko:K00821,ko:K09251	ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R01155,R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SX3_k127_3090817_3	1499967.BAYZ01000032_gene1134	3.187e-184	583.0	COG0673@1|root,COG0673@2|Bacteria,2NQM5@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
SX3_k127_3090817_18	1313172.YM304_16590	5.466e-06	58.0	COG3291@1|root,COG3391@1|root,COG3291@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3090817_19	1487953.JMKF01000019_gene2282	0.0006682	51.0	COG1462@1|root,COG1462@2|Bacteria,1G2XT@1117|Cyanobacteria,1HARS@1150|Oscillatoriales	1117|Cyanobacteria	M	Curli production assembly/transport component CsgG	-	-	-	-	-	-	-	-	-	-	-	-	CsgG
SX3_k127_3090817_12	1499967.BAYZ01000032_gene1138	2.03e-68	250.0	COG2407@1|root,COG2407@2|Bacteria	2|Bacteria	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	Fucose_iso_C
SX3_k127_3090817_9	180332.JTGN01000001_gene4745	4.921e-94	324.0	COG1653@1|root,COG1653@2|Bacteria,1W04F@1239|Firmicutes,2543W@186801|Clostridia	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
SX3_k127_3090817_10	180332.JTGN01000001_gene4744	3.336e-93	315.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	ko:K02025,ko:K15771	ko02010,map02010	M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
SX3_k127_3090817_13	180332.JTGN01000001_gene4743	3.05e-68	248.0	COG0395@1|root,COG0395@2|Bacteria,1TPRG@1239|Firmicutes,249S6@186801|Clostridia	1239|Firmicutes	P	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
SX3_k127_3090817_8	545694.TREPR_1522	1.558e-107	361.0	COG0407@1|root,COG0407@2|Bacteria,2J9RK@203691|Spirochaetes	203691|Spirochaetes	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_3090817_1	1122605.KB893637_gene3221	1.613e-199	629.0	COG0160@1|root,COG0160@2|Bacteria,4NIHH@976|Bacteroidetes,1IWIQ@117747|Sphingobacteriia	976|Bacteroidetes	E	COGs COG0160 4-aminobutyrate aminotransferase and related aminotransferase	-	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SX3_k127_3165198_1	573413.Spirs_0088	9.844e-165	533.0	COG2812@1|root,COG2812@2|Bacteria,2J5A9@203691|Spirochaetes	203691|Spirochaetes	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
SX3_k127_3165198_5	1123274.KB899407_gene394	4.493e-24	104.0	COG0718@1|root,COG0718@2|Bacteria,2J90U@203691|Spirochaetes	203691|Spirochaetes	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
SX3_k127_3165198_4	744872.Spica_0201	8.788e-72	248.0	COG0353@1|root,COG0353@2|Bacteria,2J74I@203691|Spirochaetes	203691|Spirochaetes	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
SX3_k127_3165198_0	889378.Spiaf_2854	6.614e-199	629.0	COG3408@1|root,COG3408@2|Bacteria,2J5J1@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Trehalase	-	-	-	-	-	-	-	-	-	-	-	-	Trehalase
SX3_k127_3165198_6	1480694.DC28_08865	3.311e-21	95.0	COG0721@1|root,COG0721@2|Bacteria	2|Bacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	iAF987.Gmet_0076	Glu-tRNAGln
SX3_k127_3165198_2	665571.STHERM_c22200	5.272e-144	471.0	COG0154@1|root,COG0154@2|Bacteria,2J58P@203691|Spirochaetes	203691|Spirochaetes	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
SX3_k127_3165198_3	665571.STHERM_c22190	2.812e-124	409.0	COG0064@1|root,COG0064@2|Bacteria,2J58X@203691|Spirochaetes	203691|Spirochaetes	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
SX3_k127_3169178_1	1262449.CP6013_0475	5.22e-39	151.0	COG1835@1|root,COG1835@2|Bacteria,1V7CG@1239|Firmicutes,24WKR@186801|Clostridia	186801|Clostridia	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
SX3_k127_3169178_0	1408473.JHXO01000002_gene3923	6.041e-41	164.0	COG4269@1|root,COG4269@2|Bacteria,4P9W7@976|Bacteroidetes,2FYSZ@200643|Bacteroidia	976|Bacteroidetes	S	Bacterial protein of unknown function (DUF898)	-	-	-	-	-	-	-	-	-	-	-	-	DUF898
SX3_k127_319669_0	926569.ANT_22130	2.105e-187	600.0	COG2730@1|root,COG2730@2|Bacteria	2|Bacteria	G	polysaccharide catabolic process	-	-	3.2.1.123	ko:K05991	-	-	-	-	ko00000,ko01000	-	GH5	-	Cellulase
SX3_k127_319669_3	889378.Spiaf_0627	5.079e-117	391.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,CHAT,DUF676,Hydrolase_4,LCAT,LIP,Peptidase_C14
SX3_k127_319669_6	889378.Spiaf_0626	1.109e-93	324.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,CHAT,DUF676,Hydrolase_4,LCAT,Peptidase_C14
SX3_k127_319669_5	926549.KI421517_gene1771	8.583e-98	331.0	COG2207@1|root,COG2207@2|Bacteria,4NKCH@976|Bacteroidetes,47R08@768503|Cytophagia	976|Bacteroidetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
SX3_k127_319669_11	104623.Ser39006_00506	5.794e-27	125.0	COG1879@1|root,COG1879@2|Bacteria,1NRXG@1224|Proteobacteria,1RPBV@1236|Gammaproteobacteria,3ZZY1@613|Serratia	1236|Gammaproteobacteria	G	Periplasmic substrate-binding component of the ATP-dependent ribose transport system	rbsB	GO:0003674,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006935,GO:0008150,GO:0008643,GO:0009605,GO:0015144,GO:0015145,GO:0015749,GO:0015750,GO:0015752,GO:0016020,GO:0016021,GO:0022857,GO:0030246,GO:0030288,GO:0030313,GO:0031224,GO:0031975,GO:0034219,GO:0036094,GO:0040011,GO:0042221,GO:0042330,GO:0042597,GO:0044425,GO:0044464,GO:0048029,GO:0050896,GO:0050918,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
SX3_k127_319669_7	926549.KI421517_gene3390	1.043e-78	273.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SX3_k127_319669_4	1128421.JAGA01000001_gene2223	2.796e-107	360.0	COG0673@1|root,COG0673@2|Bacteria,2NQJC@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX3_k127_319669_1	926550.CLDAP_27320	6.798e-133	441.0	COG1129@1|root,COG1129@2|Bacteria,2G649@200795|Chloroflexi	200795|Chloroflexi	P	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10441,ko:K10545,ko:K10548	ko02010,map02010	M00212,M00215,M00216	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.4,3.A.1.2.5	-	-	ABC_tran
SX3_k127_319669_9	1122132.AQYH01000007_gene1971	3.342e-70	250.0	COG1172@1|root,COG1172@2|Bacteria,1PSTG@1224|Proteobacteria,2V7KK@28211|Alphaproteobacteria,4BCQS@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
SX3_k127_319669_2	138119.DSY3745	8.085e-127	432.0	COG0407@1|root,COG0407@2|Bacteria,1TRJG@1239|Firmicutes,24B34@186801|Clostridia,26492@186807|Peptococcaceae	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_319669_10	1521187.JPIM01000021_gene145	1.897e-43	174.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,2G8GW@200795|Chloroflexi,3776B@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase, dimerisation and phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_3
SX3_k127_319669_8	1382358.JHVN01000015_gene599	1.125e-71	249.0	COG2197@1|root,COG2197@2|Bacteria,1TQ1U@1239|Firmicutes,4HA4B@91061|Bacilli,21UYT@150247|Anoxybacillus	91061|Bacilli	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
SX3_k127_3250791_35	1125701.HMPREF1221_02399	1.239e-12	75.0	COG0724@1|root,COG0724@2|Bacteria,2J7A1@203691|Spirochaetes	203691|Spirochaetes	L	DbpA RNA binding domain	-	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA
SX3_k127_3250791_32	1210884.HG799463_gene9334	4.934e-20	101.0	COG0220@1|root,COG0220@2|Bacteria,2IZJM@203682|Planctomycetes	203682|Planctomycetes	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
SX3_k127_3250791_22	1123274.KB899408_gene3788	3.806e-41	168.0	2FEHN@1|root,346H5@2|Bacteria,2J8A9@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3250791_15	573413.Spirs_0466	1.198e-63	233.0	COG0491@1|root,COG0491@2|Bacteria,2J8BJ@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG0491 Zn-dependent hydrolase including glyoxylase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SX3_k127_3250791_41	744872.Spica_2386	2.766e-05	52.0	28WTD@1|root,2ZISW@2|Bacteria,2J93F@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3250791_19	573413.Spirs_0464	8.851e-44	162.0	COG1734@1|root,COG1734@2|Bacteria,2J7Y1@203691|Spirochaetes	203691|Spirochaetes	T	Prokaryotic dksA traR C4-type zinc finger	dksA	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
SX3_k127_3250791_25	1480694.DC28_03980	3.7e-36	139.0	COG0361@1|root,COG0361@2|Bacteria,2J8JW@203691|Spirochaetes	203691|Spirochaetes	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
SX3_k127_3250791_4	1480694.DC28_04025	8.036e-127	419.0	COG1364@1|root,COG1364@2|Bacteria,2J5IC@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
SX3_k127_3250791_18	573413.Spirs_3694	6.978e-46	181.0	COG3568@1|root,COG3568@2|Bacteria,2J7FP@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Endonuclease Exonuclease phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
SX3_k127_3250791_10	1307761.L21SP2_2844	4.607e-93	317.0	COG0152@1|root,COG0152@2|Bacteria,2J6XZ@203691|Spirochaetes	203691|Spirochaetes	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
SX3_k127_3250791_13	744872.Spica_2494	2.773e-81	276.0	COG0740@1|root,COG0740@2|Bacteria,2J78H@203691|Spirochaetes	203691|Spirochaetes	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP-2	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
SX3_k127_3250791_12	552811.Dehly_1057	3.702e-85	297.0	COG0005@1|root,COG0005@2|Bacteria,2G5JP@200795|Chloroflexi,34D1X@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtaP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
SX3_k127_3250791_9	665571.STHERM_c05530	9.168e-95	327.0	COG1159@1|root,COG1159@2|Bacteria,2J671@203691|Spirochaetes	203691|Spirochaetes	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
SX3_k127_3250791_37	545694.TREPR_1084	4.536e-08	66.0	2AMUA@1|root,31CQW@2|Bacteria,2J8HP@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3250791_34	1121920.AUAU01000004_gene763	4.018e-13	73.0	COG0633@1|root,COG0633@2|Bacteria	2|Bacteria	C	Ferredoxin	-	-	4.6.1.1	ko:K01768,ko:K04755	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Guanylate_cyc
SX3_k127_3250791_24	1499967.BAYZ01000029_gene1203	1.835e-37	153.0	2EVNQ@1|root,33P2R@2|Bacteria	2|Bacteria	S	Cytochrome P460	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_P460
SX3_k127_3250791_5	1499967.BAYZ01000029_gene1202	2.294e-126	422.0	COG2114@1|root,COG5000@1|root,COG2114@2|Bacteria,COG5000@2|Bacteria,2NP16@2323|unclassified Bacteria	2|Bacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	3.1.3.3,4.6.1.1	ko:K01768,ko:K07315	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Guanylate_cyc,HAMP,Response_reg,dCache_1,dCache_3
SX3_k127_3250791_39	889378.Spiaf_0474	5.358e-07	58.0	28QN8@1|root,2ZD3W@2|Bacteria,2JBCA@203691|Spirochaetes	203691|Spirochaetes	S	DOMON domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3250791_14	351607.Acel_1993	5.422e-69	240.0	COG0177@1|root,COG0177@2|Bacteria,2GJ01@201174|Actinobacteria,4ERX8@85013|Frankiales	201174|Actinobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
SX3_k127_3250791_3	293826.Amet_3166	6.536e-145	498.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1TQ33@1239|Firmicutes,249TZ@186801|Clostridia,36VXT@31979|Clostridiaceae	186801|Clostridia	L	DNA polymerase X family	polX	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
SX3_k127_3250791_6	667014.Thein_0919	1.192e-112	375.0	COG0067@1|root,COG0067@2|Bacteria,2GGS2@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Glutamine amidotransferases class-II	-	-	-	-	-	-	-	-	-	-	-	-	GATase_2
SX3_k127_3250791_2	246194.CHY_0707	3.681e-171	551.0	COG0069@1|root,COG0069@2|Bacteria,1TQ0B@1239|Firmicutes,248IB@186801|Clostridia,42EK3@68295|Thermoanaerobacterales	186801|Clostridia	C	Belongs to the glutamate synthase family	gltB	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_7,Fer4_9,Glu_syn_central,Glu_synthase
SX3_k127_3250791_8	338963.Pcar_2600	7.998e-107	373.0	COG0070@1|root,COG0493@1|root,COG1145@1|root,COG0070@2|Bacteria,COG0493@2|Bacteria,COG1145@2|Bacteria,1PBEZ@1224|Proteobacteria,42NFW@68525|delta/epsilon subdivisions,2WIQE@28221|Deltaproteobacteria,43TK8@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	GXGXG motif	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,GXGXG,Pyr_redox_2,Pyr_redox_3,ThiF
SX3_k127_3250791_28	1123274.KB899433_gene1336	3.749e-28	123.0	COG1438@1|root,COG1438@2|Bacteria,2J7NJ@203691|Spirochaetes	203691|Spirochaetes	K	Regulates arginine biosynthesis genes	argR	-	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
SX3_k127_3250791_40	1408444.JHYC01000013_gene2473	1.204e-06	51.0	2BNP9@1|root,32HCB@2|Bacteria,1QBYA@1224|Proteobacteria,1T7JI@1236|Gammaproteobacteria,1JFGD@118969|Legionellales	118969|Legionellales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3250791_31	1123288.SOV_3c06480	2.962e-20	96.0	COG0640@1|root,COG0640@2|Bacteria,1UVRU@1239|Firmicutes,4H61R@909932|Negativicutes	909932|Negativicutes	K	SMART regulatory protein ArsR	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
SX3_k127_3250791_7	269799.Gmet_2791	4.787e-108	356.0	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,42PQM@68525|delta/epsilon subdivisions,2WJIF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	UbiE COQ5 methyltransferase	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	HTH_20,Methyltransf_31
SX3_k127_3250791_33	926569.ANT_00450	4.158e-14	74.0	COG0394@1|root,COG0394@2|Bacteria,2G6TY@200795|Chloroflexi	200795|Chloroflexi	T	Low molecular weight phosphotyrosine protein phosphatase	arsC	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	HTH_5,LMWPc
SX3_k127_3250791_27	1499967.BAYZ01000050_gene2839	9.591e-29	118.0	COG0640@1|root,COG0640@2|Bacteria,2NQ13@2323|unclassified Bacteria	2|Bacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	arsR	-	3.6.4.12	ko:K03655,ko:K03892	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	HTH_20,HTH_5
SX3_k127_3250791_0	1121405.dsmv_3545	4.033e-199	626.0	COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,42M0Z@68525|delta/epsilon subdivisions,2WK36@28221|Deltaproteobacteria,2MJ5F@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM Bile acid sodium symporter	arsB	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
SX3_k127_3250791_36	264732.Moth_1274	4.076e-11	68.0	arCOG03368@1|root,331XD@2|Bacteria,1VHY0@1239|Firmicutes,24SSZ@186801|Clostridia,42IY3@68295|Thermoanaerobacterales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3250791_16	1511.CLOST_0766	3.758e-50	183.0	COG0701@1|root,COG0701@2|Bacteria,1V5T4@1239|Firmicutes,24HM7@186801|Clostridia	186801|Clostridia	S	Predicted permease	-	-	-	-	-	-	-	-	-	-	-	-	ArsP_1
SX3_k127_3250791_17	635013.TherJR_0463	2.019e-49	192.0	COG0701@1|root,COG0701@2|Bacteria,1V49V@1239|Firmicutes,24FRM@186801|Clostridia,2622K@186807|Peptococcaceae	186801|Clostridia	S	Predicted permease	-	-	-	-	-	-	-	-	-	-	-	-	ArsP_1
SX3_k127_3250791_29	1123274.KB899427_gene3312	2.335e-26	112.0	COG0526@1|root,COG0526@2|Bacteria,2J91P@203691|Spirochaetes	203691|Spirochaetes	CO	redox-active disulfide protein 2	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
SX3_k127_3250791_30	744872.Spica_1870	1.34e-21	96.0	COG4273@1|root,COG4273@2|Bacteria	2|Bacteria	S	DGC domain	-	-	-	-	-	-	-	-	-	-	-	-	DGC
SX3_k127_3250791_1	744872.Spica_0822	1.768e-182	581.0	COG0701@1|root,COG0701@2|Bacteria	2|Bacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
SX3_k127_3250791_26	945713.IALB_2824	1.266e-33	135.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	resA	-	-	ko:K02199,ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	AhpC-TSA,Redoxin,Thioredoxin
SX3_k127_3250791_20	945713.IALB_2823	2.644e-42	164.0	COG4232@1|root,COG4232@2|Bacteria	2|Bacteria	CO	protein-disulfide reductase activity	dsbD	-	1.8.1.8	ko:K04084,ko:K06196	-	-	-	-	ko00000,ko01000,ko02000,ko03110	5.A.1.1,5.A.1.2	-	-	DsbD,Thioredoxin_7
SX3_k127_3250791_23	1123229.AUBC01000016_gene4341	5.09e-40	152.0	COG0607@1|root,COG0607@2|Bacteria,1RHQZ@1224|Proteobacteria,2U9DZ@28211|Alphaproteobacteria,3JY2J@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Rhodanese Homology Domain	MA20_01310	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
SX3_k127_3250791_11	1121335.Clst_0287	3.132e-87	310.0	COG4908@1|root,COG4908@2|Bacteria,1TQXH@1239|Firmicutes,24B2C@186801|Clostridia,3WIA6@541000|Ruminococcaceae	186801|Clostridia	S	Psort location	-	-	-	-	-	-	-	-	-	-	-	-	AATase
SX3_k127_3250791_21	1408473.JHXO01000015_gene1898	7.69e-42	162.0	2CJWB@1|root,32P4S@2|Bacteria,4NQ5Z@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Abi
SX3_k127_3250791_38	1519439.JPJG01000029_gene2362	2.003e-07	59.0	2EFH0@1|root,2ZA40@2|Bacteria,1V0W1@1239|Firmicutes,24BY4@186801|Clostridia,2N7D8@216572|Oscillospiraceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3255443_7	665571.STHERM_c13090	6.495e-92	307.0	COG0020@1|root,COG0020@2|Bacteria,2J5Y6@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
SX3_k127_3255443_18	889378.Spiaf_1990	1.887e-33	144.0	COG4589@1|root,COG4589@2|Bacteria,2J7JM@203691|Spirochaetes	203691|Spirochaetes	S	Phosphatidate cytidylyltransferase	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
SX3_k127_3255443_6	665571.STHERM_c13110	6.856e-102	344.0	COG0743@1|root,COG0743@2|Bacteria,2J5M4@203691|Spirochaetes	203691|Spirochaetes	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
SX3_k127_3255443_5	1123274.KB899412_gene1516	2.917e-108	372.0	COG0750@1|root,COG0750@2|Bacteria,2J616@203691|Spirochaetes	203691|Spirochaetes	M	zinc metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
SX3_k127_3255443_16	573413.Spirs_2871	2.092e-37	148.0	2AMCR@1|root,31C85@2|Bacteria,2J6BE@203691|Spirochaetes	203691|Spirochaetes	S	CpXC protein	-	-	-	-	-	-	-	-	-	-	-	-	CpXC
SX3_k127_3255443_21	545694.TREPR_2679	5.439e-29	135.0	2FE8F@1|root,34689@2|Bacteria,2J592@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3255443_29	1123274.KB899412_gene1513	1.149e-18	99.0	2AMU2@1|root,31CQK@2|Bacteria,2J8GC@203691|Spirochaetes	203691|Spirochaetes	S	Late competence development protein ComFB	-	-	-	ko:K02241	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	ComFB
SX3_k127_3255443_2	1123274.KB899412_gene1512	7.596e-171	547.0	COG0305@1|root,COG0305@2|Bacteria,2J590@203691|Spirochaetes	203691|Spirochaetes	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
SX3_k127_3255443_15	573413.Spirs_2875	3.076e-42	159.0	COG0359@1|root,COG0359@2|Bacteria,2J6J9@203691|Spirochaetes	203691|Spirochaetes	J	Binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
SX3_k127_3255443_26	1123274.KB899412_gene1510	1.79e-20	103.0	2DZ40@1|root,34CCA@2|Bacteria,2J8AY@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2232
SX3_k127_3255443_24	744872.Spica_1427	3.441e-24	113.0	COG0238@1|root,COG0238@2|Bacteria,2J8ZY@203691|Spirochaetes	203691|Spirochaetes	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
SX3_k127_3255443_11	744872.Spica_1428	8.989e-50	181.0	COG0629@1|root,COG0629@2|Bacteria,2J7A3@203691|Spirochaetes	203691|Spirochaetes	L	Single-stranded DNA-binding protein	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
SX3_k127_3255443_30	545695.TREAZ_0632	8.313e-16	82.0	COG0360@1|root,COG0360@2|Bacteria,2J88X@203691|Spirochaetes	203691|Spirochaetes	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
SX3_k127_3255443_27	889378.Spiaf_2000	1.272e-19	94.0	28Z99@1|root,2ZM16@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3255443_22	665571.STHERM_c10260	8.366e-29	118.0	COG0261@1|root,COG0261@2|Bacteria,2J7PP@203691|Spirochaetes	203691|Spirochaetes	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
SX3_k127_3255443_31	573413.Spirs_1803	2.266e-08	63.0	COG2868@1|root,COG2868@2|Bacteria,2J7WV@203691|Spirochaetes	203691|Spirochaetes	J	Cysteine protease Prp	-	-	-	ko:K07584	-	-	-	-	ko00000	-	-	-	Peptidase_Prp
SX3_k127_3255443_20	1123400.KB904757_gene2169	9.496e-30	120.0	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,1S8R2@1236|Gammaproteobacteria,460WG@72273|Thiotrichales	72273|Thiotrichales	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
SX3_k127_3255443_4	744872.Spica_0785	2.432e-115	383.0	COG0536@1|root,COG0536@2|Bacteria,2J5QY@203691|Spirochaetes	203691|Spirochaetes	C	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1,Radical_SAM
SX3_k127_3255443_13	665571.STHERM_c10300	2.03e-44	180.0	COG1057@1|root,COG1057@2|Bacteria,2J65I@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like,HD
SX3_k127_3255443_19	869209.Tresu_0896	2.026e-31	133.0	COG1713@1|root,COG1713@2|Bacteria,2J81K@203691|Spirochaetes	203691|Spirochaetes	H	HD superfamily hydrolase involved in NAD metabolism	-	-	-	-	-	-	-	-	-	-	-	-	HD
SX3_k127_3255443_8	1123274.KB899415_gene2423	4.705e-81	284.0	COG1316@1|root,COG1316@2|Bacteria,2J57I@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Cell envelope-related transcriptional attenuator domain	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
SX3_k127_3255443_23	1123274.KB899415_gene2424	4.488e-25	120.0	COG0799@1|root,COG0799@2|Bacteria,2J84Q@203691|Spirochaetes	203691|Spirochaetes	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
SX3_k127_3255443_12	1125700.HMPREF9195_01415	1.174e-44	176.0	COG1947@1|root,COG1947@2|Bacteria,2J7N4@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
SX3_k127_3255443_17	1123274.KB899415_gene2428	2.267e-34	136.0	COG2088@1|root,COG2088@2|Bacteria,2J7XR@203691|Spirochaetes	203691|Spirochaetes	D	Could be involved in septation	spoVG	-	-	ko:K06412	-	-	-	-	ko00000	-	-	-	SpoVG
SX3_k127_3255443_9	1480694.DC28_01175	2.206e-54	198.0	COG1825@1|root,COG1825@2|Bacteria,2J75H@203691|Spirochaetes	203691|Spirochaetes	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
SX3_k127_3255443_14	1408254.T458_25610	3.624e-43	164.0	COG0193@1|root,COG0193@2|Bacteria,1V3NB@1239|Firmicutes,4HH2Z@91061|Bacilli,26QYM@186822|Paenibacillaceae	91061|Bacilli	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
SX3_k127_3255443_10	545694.TREPR_1202	8.131e-50	195.0	COG0037@1|root,COG0037@2|Bacteria,2J638@203691|Spirochaetes	203691|Spirochaetes	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS_C
SX3_k127_3255443_1	744872.Spica_0794	2.54e-279	873.0	COG0465@1|root,COG0465@2|Bacteria,2J58Y@203691|Spirochaetes	203691|Spirochaetes	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
SX3_k127_3255443_3	665571.STHERM_c10450	3.51e-124	422.0	COG0265@1|root,COG0265@2|Bacteria,2J5SD@203691|Spirochaetes	203691|Spirochaetes	O	Trypsin domain PDZ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
SX3_k127_3255443_25	118005.AWNK01000001_gene2030	3.697e-24	113.0	COG0745@1|root,COG2172@1|root,COG0745@2|Bacteria,COG2172@2|Bacteria	2|Bacteria	T	sigma factor antagonist activity	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2,Response_reg,SpoIIE,cNMP_binding
SX3_k127_3255443_0	744872.Spica_0806	1.037e-293	913.0	COG0481@1|root,COG0481@2|Bacteria,2J5V8@203691|Spirochaetes	203691|Spirochaetes	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
SX3_k127_3371146_1	1499967.BAYZ01000142_gene6157	6.75e-53	196.0	COG1177@1|root,COG1177@2|Bacteria,2NPND@2323|unclassified Bacteria	2|Bacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K11070	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
SX3_k127_3371146_0	1380391.JIAS01000011_gene4743	7.094e-63	228.0	COG1176@1|root,COG1176@2|Bacteria,1R3XG@1224|Proteobacteria,2U2NC@28211|Alphaproteobacteria,2JX96@204441|Rhodospirillales	204441|Rhodospirillales	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02054	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
SX3_k127_3373128_19	744872.Spica_1358	6.023e-09	57.0	COG1185@1|root,COG1185@2|Bacteria,2J5BU@203691|Spirochaetes	203691|Spirochaetes	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
SX3_k127_3373128_11	938289.CAJN020000002_gene604	3.546e-28	116.0	COG0184@1|root,COG0184@2|Bacteria,1VA5C@1239|Firmicutes,24MRM@186801|Clostridia	186801|Clostridia	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
SX3_k127_3373128_9	573413.Spirs_2031	4.548e-31	138.0	COG0196@1|root,COG0196@2|Bacteria,2J7F1@203691|Spirochaetes	203691|Spirochaetes	H	riboflavin biosynthesis protein	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
SX3_k127_3373128_5	1123274.KB899421_gene1760	3.764e-68	246.0	COG0130@1|root,COG0130@2|Bacteria,2J7Q2@203691|Spirochaetes	203691|Spirochaetes	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C_2,TruB_N
SX3_k127_3373128_14	1437425.CSEC_2280	2.614e-22	100.0	COG0858@1|root,COG0858@2|Bacteria,2JG8G@204428|Chlamydiae	204428|Chlamydiae	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
SX3_k127_3373128_1	573413.Spirs_2028	1.185e-277	880.0	COG0532@1|root,COG0532@2|Bacteria,2J692@203691|Spirochaetes	203691|Spirochaetes	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
SX3_k127_3373128_3	573413.Spirs_2027	6.42e-201	640.0	COG0195@1|root,COG0195@2|Bacteria,2J624@203691|Spirochaetes	203691|Spirochaetes	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1,zf-ribbon_3
SX3_k127_3373128_12	1480694.DC28_02040	6.685e-28	119.0	COG0779@1|root,COG0779@2|Bacteria,2J87E@203691|Spirochaetes	203691|Spirochaetes	J	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
SX3_k127_3373128_10	545694.TREPR_2628	3.333e-29	126.0	COG1040@1|root,COG1040@2|Bacteria,2J807@203691|Spirochaetes	203691|Spirochaetes	S	competence protein	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
SX3_k127_3373128_0	545694.TREPR_2630	4.179e-278	884.0	COG0249@1|root,COG0249@2|Bacteria,2J5XM@203691|Spirochaetes	203691|Spirochaetes	L	This protein is involved in the repair of mismatches in DNA	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
SX3_k127_3373128_15	518766.Rmar_0873	3.969e-21	98.0	COG0816@1|root,COG0816@2|Bacteria,4NQ8B@976|Bacteroidetes,1FJID@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	J	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	ruvX	GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
SX3_k127_3373128_17	744872.Spica_1348	4.083e-15	89.0	COG2825@1|root,COG2825@2|Bacteria,2J7PA@203691|Spirochaetes	203691|Spirochaetes	M	Cationic outer membrane protein	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
SX3_k127_3373128_2	665571.STHERM_c11250	2.807e-221	713.0	COG4775@1|root,COG4775@2|Bacteria,2J5BP@203691|Spirochaetes	203691|Spirochaetes	M	Outer membrane protein assembly complex, YaeT protein	yaeT	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
SX3_k127_3373128_4	573413.Spirs_2021	6.126e-102	376.0	COG2911@1|root,COG2911@2|Bacteria,2J5CF@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Family of	-	-	-	-	-	-	-	-	-	-	-	-	TamB
SX3_k127_3373128_20	1095769.CAHF01000010_gene1170	0.0003277	52.0	COG0810@1|root,COG0810@2|Bacteria,1RJRA@1224|Proteobacteria,2VTFA@28216|Betaproteobacteria,4749W@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
SX3_k127_3373128_16	1125863.JAFN01000001_gene2656	4.034e-18	91.0	COG0848@1|root,COG0848@2|Bacteria,1PQM0@1224|Proteobacteria,42VT0@68525|delta/epsilon subdivisions,2WRBY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
SX3_k127_3373128_13	323261.Noc_2673	8.799e-23	107.0	COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,1RQWT@1236|Gammaproteobacteria,1WX5A@135613|Chromatiales	135613|Chromatiales	U	PFAM MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
SX3_k127_3373128_7	1480694.DC28_00145	8.849e-48	179.0	COG0125@1|root,COG0125@2|Bacteria,2J765@203691|Spirochaetes	203691|Spirochaetes	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
SX3_k127_3373128_6	573413.Spirs_2019	1.117e-61	218.0	2C2MH@1|root,33D2Y@2|Bacteria,2J70Q@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3373128_18	237368.SCABRO_03149	1.261e-13	74.0	COG0864@1|root,COG0864@2|Bacteria	2|Bacteria	K	response to nickel cation	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	RHH_1
SX3_k127_3373128_8	1304885.AUEY01000130_gene1258	5.821e-35	137.0	COG2337@1|root,COG2337@2|Bacteria,1RIPH@1224|Proteobacteria,42UKM@68525|delta/epsilon subdivisions,2WQZB@28221|Deltaproteobacteria,2MMDH@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
SX3_k127_3375892_0	509191.AEDB02000099_gene3936	1.029e-122	411.0	COG1009@1|root,COG1009@2|Bacteria,1TQW4@1239|Firmicutes,24A16@186801|Clostridia,3WHSP@541000|Ruminococcaceae	186801|Clostridia	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5	-	-	-	ko:K05565,ko:K14086	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M,Proton_antipo_N
SX3_k127_3382013_4	179408.Osc7112_4330	3.963e-111	364.0	COG2189@1|root,COG2189@2|Bacteria,1G0NR@1117|Cyanobacteria,1H91K@1150|Oscillatoriales	1117|Cyanobacteria	L	DNA methylase	-	-	2.1.1.72	ko:K07316	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
SX3_k127_3382013_3	76114.ebA65	1.775e-123	407.0	COG3177@1|root,COG3177@2|Bacteria,1MWAU@1224|Proteobacteria,2VH5G@28216|Betaproteobacteria,2KXZ2@206389|Rhodocyclales	206389|Rhodocyclales	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic
SX3_k127_3382013_0	179408.Osc7112_4328	0.0	1279.0	COG2442@1|root,COG3587@1|root,COG2442@2|Bacteria,COG3587@2|Bacteria,1G4HJ@1117|Cyanobacteria,1HI4J@1150|Oscillatoriales	1117|Cyanobacteria	V	Type III restriction enzyme res subunit	-	-	3.1.21.5	ko:K01156	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	ResIII
SX3_k127_3382013_1	1499967.BAYZ01000073_gene2034	1.663e-253	794.0	COG1653@1|root,COG1653@2|Bacteria	1499967.BAYZ01000073_gene2034|-	G	carbohydrate transport	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3382013_2	1499967.BAYZ01000073_gene2035	3.166e-131	425.0	COG1175@1|root,COG1175@2|Bacteria,2NPAH@2323|unclassified Bacteria	2|Bacteria	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K15771	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
SX3_k127_3382013_5	1499967.BAYZ01000073_gene2036	1.037e-83	285.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX3_k127_3392424_0	1487923.DP73_14320	3.628e-53	198.0	COG1835@1|root,COG1835@2|Bacteria,1V7CG@1239|Firmicutes,24WKR@186801|Clostridia,263B9@186807|Peptococcaceae	186801|Clostridia	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
SX3_k127_3392424_2	255470.cbdbA565	9.73e-24	105.0	2DRM1@1|root,33C8J@2|Bacteria,2GATW@200795|Chloroflexi,34DBZ@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3392424_1	1449976.KALB_8089	2.732e-44	165.0	COG3877@1|root,COG3877@2|Bacteria,2IJTS@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF2089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2089
SX3_k127_3397557_5	378806.STAUR_3557	5.922e-09	64.0	COG0515@1|root,COG0515@2|Bacteria,1Q389@1224|Proteobacteria,438Z3@68525|delta/epsilon subdivisions,2X44E@28221|Deltaproteobacteria,2YY87@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	PEGA,Pkinase
SX3_k127_3397557_4	867845.KI911784_gene3614	1.873e-09	69.0	COG1672@1|root,COG1672@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K06921	-	-	-	-	ko00000	-	-	-	AAA_16,AAA_22,AAA_35
SX3_k127_3397557_2	502025.Hoch_3346	3.249e-28	131.0	COG1262@1|root,COG2114@1|root,COG5635@1|root,COG1262@2|Bacteria,COG2114@2|Bacteria,COG5635@2|Bacteria,1R66C@1224|Proteobacteria	1224|Proteobacteria	T	NACHT domain	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,NACHT
SX3_k127_3397557_3	867845.KI911784_gene3614	2.352e-15	90.0	COG1672@1|root,COG1672@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K06921	-	-	-	-	ko00000	-	-	-	AAA_16,AAA_22,AAA_35
SX3_k127_3397557_0	278957.ABEA03000166_gene4026	3.566e-121	399.0	COG0407@1|root,COG0407@2|Bacteria	278957.ABEA03000166_gene4026|-	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3397557_1	1195236.CTER_4255	3.444e-70	243.0	COG1653@1|root,COG1653@2|Bacteria,1UYSZ@1239|Firmicutes,25BW9@186801|Clostridia	186801|Clostridia	P	solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
SX3_k127_3408455_2	1499967.BAYZ01000171_gene5550	3.144e-23	102.0	COG1633@1|root,COG1633@2|Bacteria,2NS04@2323|unclassified Bacteria	2|Bacteria	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
SX3_k127_3408455_0	1499967.BAYZ01000171_gene5554	4.926e-128	422.0	COG0543@1|root,COG0543@2|Bacteria,2NPFH@2323|unclassified Bacteria	2|Bacteria	CH	Oxidoreductase NAD-binding domain	hdrF	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
SX3_k127_3408455_1	1499967.BAYZ01000171_gene5571	4.155e-69	241.0	COG1143@1|root,COG1143@2|Bacteria,2NQ09@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	asrA	-	-	ko:K16950	ko00920,ko01120,map00920,map01120	-	R00858,R10146	RC00065	ko00000,ko00001	-	-	-	Fer4_22
SX3_k127_3424035_10	445970.ALIPUT_02137	4.091e-19	94.0	COG1595@1|root,COG1595@2|Bacteria,4NIRG@976|Bacteroidetes,2FRYA@200643|Bacteroidia,22UIK@171550|Rikenellaceae	976|Bacteroidetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SX3_k127_3424035_2	383372.Rcas_0519	3.627e-197	632.0	COG3525@1|root,COG3525@2|Bacteria,2G609@200795|Chloroflexi,376QW@32061|Chloroflexia	32061|Chloroflexia	G	Glycoside hydrolase, family 20	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_20,Glyco_hydro_20b
SX3_k127_3424035_8	545694.TREPR_2780	6.67e-79	297.0	COG0457@1|root,COG1652@1|root,COG0457@2|Bacteria,COG1652@2|Bacteria,2J7YH@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3424035_9	665571.STHERM_c00930	8.461e-66	237.0	COG1609@1|root,COG1609@2|Bacteria,2J7T4@203691|Spirochaetes	203691|Spirochaetes	K	PFAM periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
SX3_k127_3424035_0	203119.Cthe_0275	0.0	1121.0	COG3459@1|root,COG3459@2|Bacteria,1TQY8@1239|Firmicutes,248YP@186801|Clostridia,3WGK9@541000|Ruminococcaceae	186801|Clostridia	G	Glycosyltransferase family 36	-	-	2.4.1.20	ko:K00702	ko00500,ko01100,map00500,map01100	-	R00952	RC00049	ko00000,ko00001,ko01000	-	GT36	-	Glyco_hydro_36,Glyco_transf_36
SX3_k127_3424035_5	744872.Spica_0059	2.121e-99	340.0	COG1653@1|root,COG1653@2|Bacteria,2J5WB@203691|Spirochaetes	203691|Spirochaetes	G	bacterial extracellular solute-binding protein	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_8
SX3_k127_3424035_7	760011.Spico_0895	1.64e-80	282.0	COG1175@1|root,COG1175@2|Bacteria,2J71Z@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
SX3_k127_3424035_6	744872.Spica_0061	2.521e-88	310.0	COG0395@1|root,COG0395@2|Bacteria,2J5WH@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
SX3_k127_3424035_1	665571.STHERM_c02500	5.219e-268	848.0	COG3250@1|root,COG3250@2|Bacteria,2J6W2@203691|Spirochaetes	203691|Spirochaetes	G	Glycosyl hydrolases family 2	-	-	3.2.1.25	ko:K01192	ko00511,ko04142,map00511,map04142	-	-	-	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_2
SX3_k127_3424035_3	485914.Hmuk_0843	4.109e-172	557.0	arCOG14674@1|root,arCOG14674@2157|Archaea,2Y1M0@28890|Euryarchaeota,23YU1@183963|Halobacteria	183963|Halobacteria	P	Glycosyl hydrolase family 9	-	-	-	-	-	-	-	-	-	-	-	-	CelD_N,Glyco_hydro_9
SX3_k127_3424035_4	1122613.ATUP01000001_gene1705	7.934e-125	419.0	COG0520@1|root,COG0520@2|Bacteria,1N124@1224|Proteobacteria,2TZXB@28211|Alphaproteobacteria,43ZHD@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
SX3_k127_3427710_5	926549.KI421517_gene3390	9.479e-17	83.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SX3_k127_3427710_0	1499967.BAYZ01000066_gene6056	5.811e-194	630.0	COG1070@1|root,COG1070@2|Bacteria	2|Bacteria	G	xylulokinase activity	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
SX3_k127_3427710_2	1499967.BAYZ01000118_gene3283	1.923e-117	394.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
SX3_k127_3427710_1	1499967.BAYZ01000159_gene504	1.919e-139	451.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	1.1.1.370	ko:K16043	ko00562,ko01120,map00562,map01120	-	R09953	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX3_k127_3427710_8	1121438.JNJA01000003_gene2883	7.73e-09	60.0	COG5499@1|root,COG5499@2|Bacteria,1MZHS@1224|Proteobacteria,42QF1@68525|delta/epsilon subdivisions,2WKYV@28221|Deltaproteobacteria,2MDPQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	IrrE N-terminal-like domain	-	-	-	ko:K18831	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	Peptidase_M78
SX3_k127_3427710_4	686340.Metal_4021	8.561e-17	83.0	COG1201@1|root,COG1205@1|root,COG1201@2|Bacteria,COG1205@2|Bacteria,1MVGH@1224|Proteobacteria,1RQXN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	dEAD DEAH box helicase	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,DUF559,Helicase_C
SX3_k127_3427710_6	33876.JNXY01000051_gene5575	9.499e-12	67.0	COG1201@1|root,COG1205@1|root,COG1201@2|Bacteria,COG1205@2|Bacteria,2GKQ2@201174|Actinobacteria,4D9R2@85008|Micromonosporales	201174|Actinobacteria	L	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,DUF1998,Helicase_C,Pkinase
SX3_k127_3427710_11	397948.Cmaq_0099	1.07e-06	57.0	COG5550@1|root,arCOG03744@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3427710_9	706587.Desti_3188	1.002e-07	64.0	COG2041@1|root,COG2041@2|Bacteria,1MX9E@1224|Proteobacteria,42QKD@68525|delta/epsilon subdivisions,2WVK9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Oxidoreductase molybdopterin binding domain	-	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Mo-co_dimer,Oxidored_molyb
SX3_k127_3427710_7	2880.D8LD89	4.607e-09	69.0	2CYY1@1|root,2S75T@2759|Eukaryota	2759|Eukaryota	S	UbiA prenyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	UbiA
SX3_k127_3427710_3	1089547.KB913013_gene2346	4.143e-59	223.0	COG3266@1|root,COG3266@2|Bacteria,4NQBS@976|Bacteroidetes,47QPM@768503|Cytophagia	976|Bacteroidetes	S	FG-GAP repeat	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP_2
SX3_k127_3427710_10	575615.HMPREF0670_00256	2.862e-07	63.0	COG5520@1|root,COG5520@2|Bacteria	2|Bacteria	M	Belongs to the glycosyl hydrolase 30 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydr_30_2,Glyco_hydro_30C
SX3_k127_3437828_0	1232453.BAIF02000004_gene1569	3.063e-142	457.0	28MXM@1|root,2Z8AT@2|Bacteria,1V0XI@1239|Firmicutes,24DIS@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3437828_1	1232453.BAIF02000054_gene1201	5.128e-115	389.0	COG0407@1|root,COG0407@2|Bacteria,1V4YU@1239|Firmicutes,24KSS@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_3437828_3	545695.TREAZ_3613	1.646e-40	167.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
SX3_k127_3437828_2	768710.DesyoDRAFT_5285	6.23e-46	180.0	COG0407@1|root,COG0407@2|Bacteria,1UZD2@1239|Firmicutes,24C43@186801|Clostridia,26302@186807|Peptococcaceae	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_3437828_4	1267533.KB906737_gene1903	7.638e-28	112.0	COG3254@1|root,COG3254@2|Bacteria	2|Bacteria	S	rhamnose metabolic process	-	-	5.1.3.32	ko:K03534	-	-	R10819	RC00563	ko00000,ko01000	-	-	-	rhaM
SX3_k127_3448463_2	1121346.KB899812_gene2139	6.244e-71	244.0	COG2407@1|root,COG2407@2|Bacteria,1TQDX@1239|Firmicutes,4HCRT@91061|Bacilli,26VSZ@186822|Paenibacillaceae	91061|Bacilli	G	isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_Isome,Fucose_iso_C
SX3_k127_3448463_5	1120746.CCNL01000008_gene841	2.272e-54	199.0	COG2188@1|root,COG2188@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
SX3_k127_3448463_1	28532.XP_010522182.1	4.913e-73	259.0	COG0524@1|root,KOG2855@2759|Eukaryota,37KZV@33090|Viridiplantae,3GFFE@35493|Streptophyta,3HWA1@3699|Brassicales	35493|Streptophyta	G	Belongs to the carbohydrate kinase PfkB family	frk1	GO:0003674,GO:0003824,GO:0004396,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0005975,GO:0005996,GO:0006000,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008865,GO:0009506,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019318,GO:0030054,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046835,GO:0055044,GO:0071704,GO:0071944	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
SX3_k127_3448463_6	1245469.S58_67860	5.287e-43	169.0	COG0412@1|root,COG0412@2|Bacteria,1RG6A@1224|Proteobacteria,2U7V6@28211|Alphaproteobacteria,3K6AI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DLH
SX3_k127_3448463_4	314278.NB231_11404	5.366e-56	214.0	COG2105@1|root,COG2105@2|Bacteria,1RH3X@1224|Proteobacteria,1S68T@1236|Gammaproteobacteria,1WYAJ@135613|Chromatiales	135613|Chromatiales	S	PFAM AIG2-like	-	-	-	-	-	-	-	-	-	-	-	-	GGACT
SX3_k127_3448463_8	596153.Alide_2680	5.811e-08	65.0	COG2020@1|root,COG2020@2|Bacteria,1MZ7S@1224|Proteobacteria,2VU4G@28216|Betaproteobacteria,4AEVT@80864|Comamonadaceae	28216|Betaproteobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
SX3_k127_3448463_3	326427.Cagg_0341	2.3e-61	234.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,2G8GW@200795|Chloroflexi,3776B@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase, dimerisation and phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_3
SX3_k127_3448463_0	1121434.AULY01000010_gene2320	3.155e-80	273.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,42Q40@68525|delta/epsilon subdivisions,2WKYI@28221|Deltaproteobacteria,2MA7Y@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	response regulator, receiver	-	-	-	ko:K02479	-	-	-	-	ko00000,ko02022	-	-	-	GerE,Response_reg
SX3_k127_3448463_7	1160707.AJIK01000010_gene2473	1.465e-14	78.0	COG2197@1|root,COG2197@2|Bacteria,1TRXG@1239|Firmicutes,4HCCV@91061|Bacilli,26CVX@186818|Planococcaceae	91061|Bacilli	T	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	yhcZ	-	-	ko:K02479	-	-	-	-	ko00000,ko02022	-	-	-	GerE,Response_reg
SX3_k127_3452561_2	926550.CLDAP_15530	1.227e-98	326.0	COG1079@1|root,COG1079@2|Bacteria,2G7KY@200795|Chloroflexi	200795|Chloroflexi	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
SX3_k127_3452561_1	926569.ANT_07410	8.432e-145	469.0	COG4603@1|root,COG4603@2|Bacteria,2G81C@200795|Chloroflexi	200795|Chloroflexi	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
SX3_k127_3452561_0	926569.ANT_07400	1.827e-200	639.0	COG3845@1|root,COG3845@2|Bacteria,2G7UR@200795|Chloroflexi	200795|Chloroflexi	S	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
SX3_k127_3452561_3	926569.ANT_07390	6.92e-47	170.0	COG1744@1|root,COG1744@2|Bacteria,2G85I@200795|Chloroflexi	200795|Chloroflexi	S	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
SX3_k127_3509879_1	794903.OPIT5_19945	2.219e-96	325.0	COG0111@1|root,COG0111@2|Bacteria,46XXJ@74201|Verrucomicrobia,3K8JZ@414999|Opitutae	414999|Opitutae	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
SX3_k127_3509879_4	1195236.CTER_2352	1.957e-25	121.0	COG1653@1|root,COG1653@2|Bacteria,1TQJE@1239|Firmicutes,2496C@186801|Clostridia	186801|Clostridia	G	solute-binding protein	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8
SX3_k127_3509879_2	1089548.KI783301_gene1324	6.472e-50	191.0	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,4H9NG@91061|Bacilli,3WEBK@539002|Bacillales incertae sedis	91061|Bacilli	K	Catabolite control protein A	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
SX3_k127_3509879_0	573413.Spirs_4115	9.109e-177	567.0	COG1640@1|root,COG1640@2|Bacteria,2J5U4@203691|Spirochaetes	203691|Spirochaetes	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
SX3_k127_3509879_6	1173028.ANKO01000017_gene97	2.549e-14	78.0	2E90H@1|root,3339X@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3509879_5	1173028.ANKO01000017_gene96	2.128e-23	101.0	2C1SS@1|root,32YN6@2|Bacteria,1G9HK@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3509879_3	1499967.BAYZ01000171_gene5550	6.092e-32	127.0	COG1633@1|root,COG1633@2|Bacteria,2NS04@2323|unclassified Bacteria	2|Bacteria	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
SX3_k127_3522487_0	1117647.M5M_16605	1.01e-81	278.0	COG1940@1|root,COG1940@2|Bacteria,1NFM0@1224|Proteobacteria,1RNEA@1236|Gammaproteobacteria,1JBY9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	GK	ROK family	nagC	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	2.7.1.2	ko:K00845,ko:K02565,ko:K15545	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko03000	-	-	-	MarR,ROK
SX3_k127_3522487_1	411902.CLOBOL_02527	1.478e-62	226.0	COG0279@1|root,COG0279@2|Bacteria,1V5W5@1239|Firmicutes,24INX@186801|Clostridia,21Y20@1506553|Lachnoclostridium	186801|Clostridia	G	SIS domain	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
SX3_k127_3522487_2	906968.Trebr_1504	4.1e-12	70.0	COG2265@1|root,COG2265@2|Bacteria,2J5Y7@203691|Spirochaetes	203691|Spirochaetes	H	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	ygcA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
SX3_k127_3525983_4	1307761.L21SP2_1751	1.245e-39	151.0	COG0669@1|root,COG0669@2|Bacteria,2J7VS@203691|Spirochaetes	203691|Spirochaetes	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
SX3_k127_3525983_8	665571.STHERM_c11910	1.07e-25	113.0	2FCY0@1|root,3437Z@2|Bacteria,2JBFD@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3525983_2	1123274.KB899415_gene2493	2.847e-58	210.0	COG1413@1|root,COG1413@2|Bacteria,2J61J@203691|Spirochaetes	203691|Spirochaetes	C	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
SX3_k127_3525983_5	573413.Spirs_1883	1.069e-32	134.0	COG1695@1|root,COG1695@2|Bacteria,2J9HG@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR,Vir_act_alpha_C
SX3_k127_3525983_10	1123274.KB899415_gene2491	5.14e-20	96.0	2EFYN@1|root,339QT@2|Bacteria,2J8BI@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3525983_9	545694.TREPR_3161	6.696e-21	97.0	COG0792@1|root,COG0792@2|Bacteria,2J8CV@203691|Spirochaetes	203691|Spirochaetes	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
SX3_k127_3525983_0	744872.Spica_0482	6.032e-107	361.0	COG2206@1|root,COG2206@2|Bacteria,2J6GF@203691|Spirochaetes	203691|Spirochaetes	T	HD domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD,HD_5
SX3_k127_3525983_11	643648.Slip_0916	5.7e-14	74.0	COG2257@1|root,COG2257@2|Bacteria,1VF4R@1239|Firmicutes,24QSW@186801|Clostridia,42KRI@68298|Syntrophomonadaceae	186801|Clostridia	N	FlhB HrpN YscU SpaS Family	flhB1	-	-	ko:K04061	-	-	-	-	ko00000,ko02044	-	-	-	Bac_export_2
SX3_k127_3525983_3	1123274.KB899415_gene2485	6.41e-49	179.0	COG0335@1|root,COG0335@2|Bacteria,2J8P4@203691|Spirochaetes	203691|Spirochaetes	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
SX3_k127_3525983_1	1123274.KB899415_gene2484	3.795e-82	289.0	COG0336@1|root,COG0336@2|Bacteria,2J5KR@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
SX3_k127_3525983_7	1125701.HMPREF1221_01989	4.597e-27	119.0	COG0806@1|root,COG0806@2|Bacteria,2J73Y@203691|Spirochaetes	203691|Spirochaetes	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
SX3_k127_3525983_6	1123274.KB899415_gene2482	1.421e-27	112.0	COG1837@1|root,COG1837@2|Bacteria,2J92T@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the UPF0109 family	yhbY	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
SX3_k127_3544356_0	545695.TREAZ_1706	3.232e-314	1030.0	COG2373@1|root,COG2373@2|Bacteria,2J5M0@203691|Spirochaetes	203691|Spirochaetes	S	Alpha-2-macroglobulin family	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,Big_5,MG1
SX3_k127_3544356_4	1123274.KB899417_gene2166	6.631e-109	370.0	COG0544@1|root,COG0544@2|Bacteria,2J5FS@203691|Spirochaetes	203691|Spirochaetes	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
SX3_k127_3544356_5	1125699.HMPREF9194_01523	8.861e-91	302.0	COG0740@1|root,COG0740@2|Bacteria,2J5VY@203691|Spirochaetes	203691|Spirochaetes	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
SX3_k127_3544356_2	1123274.KB899417_gene2164	1.167e-192	608.0	COG1219@1|root,COG1219@2|Bacteria,2J5FF@203691|Spirochaetes	203691|Spirochaetes	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
SX3_k127_3544356_1	573413.Spirs_1293	1.326e-271	876.0	COG0466@1|root,COG0466@2|Bacteria,2J71Y@203691|Spirochaetes	203691|Spirochaetes	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon-2	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
SX3_k127_3544356_3	903818.KI912268_gene3327	1.356e-131	434.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cyt_bd_oxida_I,Cytochrome_CBB3
SX3_k127_3546362_3	742733.HMPREF9469_03516	8.621e-34	136.0	COG1940@1|root,COG1940@2|Bacteria,1TRGJ@1239|Firmicutes,248TJ@186801|Clostridia,21Z9D@1506553|Lachnoclostridium	186801|Clostridia	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
SX3_k127_3546362_0	665571.STHERM_c02830	1.06e-258	803.0	COG0174@1|root,COG0174@2|Bacteria,2J6JS@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
SX3_k127_3546362_1	398512.JQKC01000028_gene3885	1.019e-102	354.0	COG2272@1|root,COG2272@2|Bacteria,1UXY5@1239|Firmicutes,24CHT@186801|Clostridia,3WHM6@541000|Ruminococcaceae	186801|Clostridia	I	Carboxylesterase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
SX3_k127_3546362_5	584708.Apau_0649	3.812e-23	111.0	COG1131@1|root,COG1131@2|Bacteria,3TA99@508458|Synergistetes	508458|Synergistetes	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_3546362_4	1047013.AQSP01000113_gene739	3.291e-25	106.0	COG4868@1|root,COG4868@2|Bacteria,2NQM9@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF1846)	XK27_07020	-	-	-	-	-	-	-	-	-	-	-	DUF1846
SX3_k127_3572935_7	203124.Tery_1783	1.521e-05	52.0	COG1474@1|root,COG1672@1|root,COG1474@2|Bacteria,COG1672@2|Bacteria,1G3WH@1117|Cyanobacteria,1HH9F@1150|Oscillatoriales	1117|Cyanobacteria	LO	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
SX3_k127_3572935_2	666510.ASAC_0944	9.73e-29	121.0	COG0251@1|root,arCOG01630@2157|Archaea,2XQQW@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
SX3_k127_3572935_1	335543.Sfum_3382	8.269e-66	234.0	COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,43EVS@68525|delta/epsilon subdivisions,2X9S4@28221|Deltaproteobacteria,2MSFB@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	HAD-hyrolase-like	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
SX3_k127_3572935_5	671143.DAMO_1478	3.428e-19	91.0	COG0864@1|root,COG0864@2|Bacteria	2|Bacteria	K	response to nickel cation	-	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0008150,GO:0040008,GO:0045926,GO:0045927,GO:0048518,GO:0048519,GO:0050789,GO:0065007,GO:0097159,GO:1901363	-	-	-	-	-	-	-	-	-	-	RHH_1
SX3_k127_3572935_4	690850.Desaf_1754	7.896e-28	119.0	COG2337@1|root,COG2337@2|Bacteria,1MYU1@1224|Proteobacteria,42UNN@68525|delta/epsilon subdivisions,2WQA2@28221|Deltaproteobacteria,2MFFM@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Toxic component of a toxin-antitoxin (TA) module	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
SX3_k127_3572935_3	1195236.CTER_3283	7.388e-28	128.0	2BVX8@1|root,30QZQ@2|Bacteria,1V7D8@1239|Firmicutes,24HBU@186801|Clostridia,3WPKX@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3572935_0	926550.CLDAP_35980	3.97e-101	341.0	COG0449@1|root,COG0449@2|Bacteria,2G5V6@200795|Chloroflexi	200795|Chloroflexi	M	PFAM sugar isomerase (SIS)	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	SIS
SX3_k127_3572935_6	1226325.HMPREF1548_00710	3.199e-08	62.0	COG0500@1|root,COG2226@2|Bacteria,1TQEA@1239|Firmicutes,24HII@186801|Clostridia,36FRR@31979|Clostridiaceae	186801|Clostridia	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31
SX3_k127_3594094_0	573413.Spirs_2610	9.803e-248	779.0	COG1256@1|root,COG4786@1|root,COG1256@2|Bacteria,COG4786@2|Bacteria,2J5TQ@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook-associated protein, FlgK	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_IN,Flg_bbr_C
SX3_k127_3594094_2	889378.Spiaf_0795	2.095e-122	405.0	COG1344@1|root,COG1344@2|Bacteria,2J6BJ@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook-associated protein 3	flgL	-	-	ko:K02397	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_IN,Flagellin_N
SX3_k127_3594094_5	545694.TREPR_1921	2.684e-52	188.0	COG1699@1|root,COG1699@2|Bacteria,2J7ZU@203691|Spirochaetes	203691|Spirochaetes	N	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum	fliW	-	-	ko:K13626	-	-	-	-	ko00000,ko02035	-	-	-	FliW
SX3_k127_3594094_11	1408306.JHXX01000003_gene1289	1.202e-09	65.0	COG1551@1|root,COG1551@2|Bacteria,1VEEF@1239|Firmicutes,24QPD@186801|Clostridia,4BZW0@830|Butyrivibrio	186801|Clostridia	T	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding	csrA	-	-	ko:K03563	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03019	-	-	-	CsrA
SX3_k127_3594094_3	545694.TREPR_1923	2.501e-86	299.0	COG2206@1|root,COG2206@2|Bacteria,2J588@203691|Spirochaetes	203691|Spirochaetes	T	HD domain protein	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5
SX3_k127_3594094_8	1123274.KB899419_gene1884	2.792e-28	128.0	COG1214@1|root,COG1214@2|Bacteria,2J80U@203691|Spirochaetes	203691|Spirochaetes	O	Universal bacterial protein YeaZ	yeaZ	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
SX3_k127_3594094_7	906968.Trebr_1550	1.274e-32	134.0	COG0802@1|root,COG0802@2|Bacteria,2J8H4@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Uncharacterised protein family UPF0079, ATPase	-	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
SX3_k127_3594094_4	573413.Spirs_2602	7.538e-54	208.0	COG5581@1|root,COG5581@2|Bacteria	2|Bacteria	M	regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
SX3_k127_3594094_9	1123274.KB899419_gene1888	7.899e-22	112.0	2FFSV@1|root,347Q1@2|Bacteria,2J89P@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3594094_1	665571.STHERM_c07710	6.689e-161	529.0	COG1345@1|root,COG1345@2|Bacteria,2J6CW@203691|Spirochaetes	203691|Spirochaetes	N	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end	fliD	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	-	ko:K02407	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliD_C,FliD_N
SX3_k127_3594094_10	221027.JO40_11940	1.673e-10	71.0	COG1334@1|root,COG1334@2|Bacteria,2J8TD@203691|Spirochaetes	203691|Spirochaetes	N	FlaG protein	flaG	-	-	ko:K06603	-	-	-	-	ko00000,ko02035	-	-	-	FlaG
SX3_k127_3594094_6	665571.STHERM_c07730	5.882e-37	141.0	COG1344@1|root,COG1344@2|Bacteria,2J5NR@203691|Spirochaetes	203691|Spirochaetes	N	Component of the core of the flagella	flaB3	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
SX3_k127_3598527_23	545695.TREAZ_1000	1.309e-70	251.0	COG1193@1|root,COG1193@2|Bacteria,2J59D@203691|Spirochaetes	203691|Spirochaetes	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
SX3_k127_3598527_0	573413.Spirs_2452	0.0	1370.0	COG0178@1|root,COG0178@2|Bacteria,2J5BN@203691|Spirochaetes	203691|Spirochaetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
SX3_k127_3598527_13	665571.STHERM_c11980	1.082e-121	438.0	COG1452@1|root,COG1452@2|Bacteria,2J5EC@203691|Spirochaetes	203691|Spirochaetes	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3598527_15	573413.Spirs_2450	6.983e-112	369.0	COG1702@1|root,COG1702@2|Bacteria,2J64H@203691|Spirochaetes	203691|Spirochaetes	T	Phosphate starvation-inducible protein PhoH	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
SX3_k127_3598527_11	744872.Spica_1228	7.829e-140	473.0	COG1480@1|root,COG1480@2|Bacteria,2J5K4@203691|Spirochaetes	203691|Spirochaetes	S	7TM receptor with intracellular HD hydrolase	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
SX3_k127_3598527_44	545694.TREPR_1688	1.158e-27	117.0	COG0319@1|root,COG0319@2|Bacteria,2J7YN@203691|Spirochaetes	203691|Spirochaetes	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
SX3_k127_3598527_18	754027.HMPREF9554_03066	4.457e-99	348.0	COG0457@1|root,COG0457@2|Bacteria,2J5SR@203691|Spirochaetes	203691|Spirochaetes	S	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC3,TPR_16,TPR_19,TPR_6,TPR_8
SX3_k127_3598527_8	665571.STHERM_c09800	7.096e-171	545.0	COG0126@1|root,COG0126@2|Bacteria,2J68Y@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
SX3_k127_3598527_19	665571.STHERM_c09810	5.783e-93	312.0	COG0149@1|root,COG0149@2|Bacteria,2J5FV@203691|Spirochaetes	203691|Spirochaetes	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
SX3_k127_3598527_42	1123274.KB899419_gene1973	3.389e-30	123.0	COG1314@1|root,COG1314@2|Bacteria,2J7UR@203691|Spirochaetes	203691|Spirochaetes	U	Preprotein translocase SecG subunit	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
SX3_k127_3598527_34	744872.Spica_1823	2.893e-40	154.0	COG1762@1|root,COG1762@2|Bacteria,2J7SC@203691|Spirochaetes	203691|Spirochaetes	GT	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	-	-	2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2
SX3_k127_3598527_37	545694.TREPR_1147	6.888e-34	144.0	COG1527@1|root,COG1527@2|Bacteria,2J5RM@203691|Spirochaetes	203691|Spirochaetes	C	ATP synthase (C/AC39) subunit	-	-	-	-	-	-	-	-	-	-	-	-	vATP-synt_AC39
SX3_k127_3598527_10	1321815.HMPREF9193_01396	8.217e-152	503.0	COG1269@1|root,COG1269@2|Bacteria,2J6DX@203691|Spirochaetes	203691|Spirochaetes	U	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
SX3_k127_3598527_46	545695.TREAZ_3403	1.117e-25	123.0	COG0636@1|root,COG0636@2|Bacteria,2J8ME@203691|Spirochaetes	203691|Spirochaetes	P	ATP synthase subunit C	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
SX3_k127_3598527_43	906968.Trebr_1700	1.148e-29	121.0	COG1436@1|root,COG1436@2|Bacteria,2J8AJ@203691|Spirochaetes	203691|Spirochaetes	C	-ATPase subunit F	-	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
SX3_k127_3598527_54	1125699.HMPREF9194_00495	4.283e-11	72.0	2C65T@1|root,301BP@2|Bacteria,2J7YG@203691|Spirochaetes	203691|Spirochaetes	S	ATPase subunit E	-	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	-
SX3_k127_3598527_3	1321815.HMPREF9193_01400	6.274e-264	826.0	COG1155@1|root,COG1155@2|Bacteria,2J5EF@203691|Spirochaetes	203691|Spirochaetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
SX3_k127_3598527_5	906968.Trebr_1697	6.652e-229	715.0	COG1156@1|root,COG1156@2|Bacteria,2J5SP@203691|Spirochaetes	203691|Spirochaetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
SX3_k127_3598527_25	906968.Trebr_1696	6.65e-66	236.0	COG1394@1|root,COG1394@2|Bacteria,2J5V1@203691|Spirochaetes	203691|Spirochaetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
SX3_k127_3598527_30	545695.TREAZ_3416	5.37e-52	190.0	COG0589@1|root,COG0589@2|Bacteria,2J7EV@203691|Spirochaetes	203691|Spirochaetes	T	universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
SX3_k127_3598527_39	1307761.L21SP2_1866	9.958e-33	132.0	COG0716@1|root,COG0716@2|Bacteria,2J892@203691|Spirochaetes	203691|Spirochaetes	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3598527_26	545695.TREAZ_1217	4.883e-63	225.0	2BZW8@1|root,32R5W@2|Bacteria,2J6GZ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3598527_27	889378.Spiaf_1628	1.808e-61	221.0	COG2214@1|root,COG2214@2|Bacteria,2J5G9@203691|Spirochaetes	203691|Spirochaetes	O	DnaJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
SX3_k127_3598527_29	1123274.KB899419_gene1975	2.939e-58	216.0	COG0760@1|root,COG0760@2|Bacteria,2J6I2@203691|Spirochaetes	203691|Spirochaetes	M	peptidylprolyl isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
SX3_k127_3598527_33	744872.Spica_0924	1.003e-47	176.0	COG0781@1|root,COG0781@2|Bacteria,2J7V3@203691|Spirochaetes	203691|Spirochaetes	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
SX3_k127_3598527_40	759914.BP951000_1248	1.255e-32	132.0	COG1664@1|root,COG1664@2|Bacteria,2J8N1@203691|Spirochaetes	203691|Spirochaetes	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
SX3_k127_3598527_20	665571.STHERM_c09880	3.31e-90	305.0	COG0024@1|root,COG0024@2|Bacteria,2J5Z7@203691|Spirochaetes	203691|Spirochaetes	J	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
SX3_k127_3598527_21	744872.Spica_1033	4.652e-86	291.0	COG2236@1|root,COG2236@2|Bacteria,2J5KF@203691|Spirochaetes	203691|Spirochaetes	F	phosphoribosyl transferase	-	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
SX3_k127_3598527_57	649638.Trad_1790	0.0001465	53.0	COG4758@1|root,COG4758@2|Bacteria,1WKNW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154
SX3_k127_3598527_12	545694.TREPR_1730	4.582e-125	419.0	COG0621@1|root,COG0621@2|Bacteria,2J5GF@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
SX3_k127_3598527_58	406124.ACPC01000020_gene3952	0.0002095	53.0	COG0860@1|root,COG0860@2|Bacteria,1V3MD@1239|Firmicutes,4HHD1@91061|Bacilli,1ZBPF@1386|Bacillus	91061|Bacilli	M	n-acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,Glucosaminidase,SH3_3,SLH,SPOR
SX3_k127_3598527_28	1123274.KB899419_gene1992	4.754e-60	235.0	2F8XC@1|root,34196@2|Bacteria,2J6EN@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3598527_16	573413.Spirs_2422	1.745e-105	358.0	COG0618@1|root,COG0618@2|Bacteria,2J74X@203691|Spirochaetes	203691|Spirochaetes	S	DHHA1 domain	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
SX3_k127_3598527_55	589865.DaAHT2_1368	3.119e-07	62.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,42Y4X@68525|delta/epsilon subdivisions,2WUQC@28221|Deltaproteobacteria,2MPZ6@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Belongs to the bacterial plant glucose-1-phosphate adenylyltransferase family	-	-	2.7.7.27,2.7.7.91	ko:K00975,ko:K20427	ko00500,ko00520,ko00525,ko01100,ko01110,ko01130,ko02026,map00500,map00520,map00525,map01100,map01110,map01130,map02026	M00565,M00814	R00948,R11237,R11246,R11402	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
SX3_k127_3598527_31	1123274.KB899419_gene1994	4.904e-50	196.0	COG2304@1|root,COG2304@2|Bacteria,2J712@203691|Spirochaetes	203691|Spirochaetes	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
SX3_k127_3598527_2	573413.Spirs_2420	1.633e-319	989.0	2EZDZ@1|root,33SJ6@2|Bacteria,2J6M2@203691|Spirochaetes	203691|Spirochaetes	S	Cytoplasmic filament protein A	cfpA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3598527_17	1123274.KB899419_gene1996	1.037e-101	342.0	2F0EQ@1|root,33THS@2|Bacteria,2J5ZQ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3598527_1	573413.Spirs_2418	0.0	1109.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2J6C2@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the PEP-utilizing enzyme family	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C
SX3_k127_3598527_22	744872.Spica_1146	3.182e-74	283.0	COG0457@1|root,COG0457@2|Bacteria,2J58A@203691|Spirochaetes	203691|Spirochaetes	S	TPR domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_8
SX3_k127_3598527_48	530564.Psta_3315	9.423e-24	117.0	COG0840@1|root,COG2202@1|root,COG0840@2|Bacteria,COG2202@2|Bacteria,2IXQA@203682|Planctomycetes	203682|Planctomycetes	NT	Methyl-accepting chemotaxis protein (MCP) signaling domain	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal,PAS_4,PAS_9
SX3_k127_3598527_9	1123274.KB899424_gene3019	1.552e-168	544.0	COG0015@1|root,COG0015@2|Bacteria,2J60J@203691|Spirochaetes	203691|Spirochaetes	F	Adenylosuccinate lyase	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,ASL_C,Lyase_1
SX3_k127_3598527_7	665571.STHERM_c10030	3.652e-214	679.0	COG0519@1|root,COG0519@2|Bacteria,2J5C7@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	Asn_synthase,GATase,GMP_synt_C,NAD_synthase
SX3_k127_3598527_47	744872.Spica_1489	8.122e-25	112.0	28YH3@1|root,2ZKB9@2|Bacteria,2J8G8@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3598527_45	744872.Spica_1488	1.435e-27	126.0	2ANXQ@1|root,31DYJ@2|Bacteria,2JB6C@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3598527_24	1219084.AP014508_gene1112	2.69e-68	256.0	COG1269@1|root,COG1269@2|Bacteria	2|Bacteria	C	ATP hydrolysis coupled proton transport	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	Peptidase_M28,V_ATPase_I
SX3_k127_3598527_35	515635.Dtur_1505	2.179e-39	151.0	COG0636@1|root,COG0636@2|Bacteria	2|Bacteria	C	ATP hydrolysis coupled proton transport	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042802,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110,ko:K02124	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157,M00159	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1,3.A.2.2,3.A.2.3	-	-	ATP-synt_C
SX3_k127_3598527_56	857293.CAAU_0423	3.181e-07	63.0	COG1527@1|root,COG1527@2|Bacteria,1U6WZ@1239|Firmicutes,249XD@186801|Clostridia,36DZ2@31979|Clostridiaceae	186801|Clostridia	C	C subunit	ntpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
SX3_k127_3598527_51	1297617.JPJD01000013_gene927	8.34e-16	81.0	COG1436@1|root,COG1436@2|Bacteria,1VAX7@1239|Firmicutes,24MXC@186801|Clostridia,269F0@186813|unclassified Clostridiales	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
SX3_k127_3598527_4	555079.Toce_2042	2.459e-249	782.0	COG1155@1|root,COG1155@2|Bacteria,1TPGS@1239|Firmicutes,24882@186801|Clostridia,42ETB@68295|Thermoanaerobacterales	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
SX3_k127_3598527_6	555079.Toce_2041	1.141e-214	679.0	COG1156@1|root,COG1156@2|Bacteria,1VSU1@1239|Firmicutes,2496H@186801|Clostridia,42FIF@68295|Thermoanaerobacterales	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
SX3_k127_3598527_32	994573.T472_0215075	2.041e-48	180.0	COG1394@1|root,COG1394@2|Bacteria,1TQ1Y@1239|Firmicutes,247TC@186801|Clostridia,36E0U@31979|Clostridiaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
SX3_k127_3598527_14	665571.STHERM_c12020	1.115e-121	404.0	COG0821@1|root,COG0821@2|Bacteria,2J5UT@203691|Spirochaetes	203691|Spirochaetes	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
SX3_k127_3598527_41	744872.Spica_1497	3.708e-31	135.0	COG3118@1|root,COG3118@2|Bacteria,2J76D@203691|Spirochaetes	203691|Spirochaetes	O	belongs to the thioredoxin family	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3598527_50	1123070.KB899256_gene2175	1.741e-19	92.0	COG2161@1|root,COG2161@2|Bacteria	2|Bacteria	D	toxin-antitoxin pair type II binding	-	-	2.3.1.15	ko:K08591,ko:K19159	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004,ko02048	-	-	-	PhdYeFM_antitox
SX3_k127_3598527_38	944480.ATUV01000001_gene1652	7.597e-34	131.0	COG4115@1|root,COG4115@2|Bacteria,1N0WH@1224|Proteobacteria,42U3X@68525|delta/epsilon subdivisions,2WQCX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	TIGRFAM addiction module toxin, Txe YoeB family	-	-	-	-	-	-	-	-	-	-	-	-	YoeB_toxin
SX3_k127_3598527_49	1235279.C772_01349	8.629e-20	98.0	COG4430@1|root,COG4430@2|Bacteria,1VG0C@1239|Firmicutes,4HQHY@91061|Bacilli	91061|Bacilli	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3610714_0	1499967.BAYZ01000016_gene6563	3.712e-263	844.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria	2|Bacteria	I	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
SX3_k127_3610714_1	545694.TREPR_3200	4.422e-37	143.0	COG1066@1|root,COG1066@2|Bacteria,2J5WN@203691|Spirochaetes	203691|Spirochaetes	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	ATPase,ChlI,Lon_C
SX3_k127_3621009_8	368408.Tpen_0110	1.415e-35	146.0	COG0399@1|root,arCOG00118@2157|Archaea,2XQAK@28889|Crenarchaeota	28889|Crenarchaeota	E	Belongs to the DegT DnrJ EryC1 family	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
SX3_k127_3621009_4	1144319.PMI16_03218	8.414e-80	285.0	COG1653@1|root,COG1653@2|Bacteria,1MWHT@1224|Proteobacteria,2VP3P@28216|Betaproteobacteria	28216|Betaproteobacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K02027,ko:K10117	ko02010,map02010	M00196,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8
SX3_k127_3621009_6	180332.JTGN01000019_gene1362	5.173e-48	183.0	COG1175@1|root,COG1175@2|Bacteria,1U7MW@1239|Firmicutes,24IXZ@186801|Clostridia	186801|Clostridia	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
SX3_k127_3621009_7	324057.Pjdr2_0193	1.862e-45	175.0	COG0395@1|root,COG0395@2|Bacteria,1TR45@1239|Firmicutes,4HCEH@91061|Bacilli,26VP8@186822|Paenibacillaceae	91061|Bacilli	G	Sugar permease	msmG	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
SX3_k127_3621009_5	479435.Kfla_4513	1.004e-50	190.0	COG2120@1|root,COG2120@2|Bacteria	2|Bacteria	S	N-acetylglucosaminylinositol deacetylase activity	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
SX3_k127_3621009_3	425104.Ssed_2790	2.349e-81	277.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria,2Q9RW@267890|Shewanellaceae	1236|Gammaproteobacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm2	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
SX3_k127_3621009_1	425104.Ssed_2791	6.909e-136	462.0	COG4262@1|root,COG4262@2|Bacteria,1QUPY@1224|Proteobacteria,1RMJV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
SX3_k127_3621009_0	204669.Acid345_2237	4.96e-219	699.0	COG0021@1|root,COG0021@2|Bacteria	2|Bacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
SX3_k127_3621009_2	158190.SpiGrapes_0167	8.396e-96	325.0	COG1744@1|root,COG1744@2|Bacteria,2J572@203691|Spirochaetes	203691|Spirochaetes	S	Basic membrane protein	tpn38b	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
SX3_k127_3621009_9	457421.CBFG_00483	6.776e-21	95.0	COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,24XN8@186801|Clostridia,26845@186813|unclassified Clostridiales	186801|Clostridia	S	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
SX3_k127_3628449_0	760011.Spico_1592	1.369e-98	334.0	COG0322@1|root,COG0322@2|Bacteria,2J69M@203691|Spirochaetes	203691|Spirochaetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
SX3_k127_3628449_2	69395.JQLZ01000004_gene534	2.489e-07	60.0	2CCFH@1|root,301N0@2|Bacteria,1R5U0@1224|Proteobacteria,2U4RK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3628449_1	1265505.ATUG01000002_gene1898	3.551e-20	106.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	PKD,Peptidase_S8
SX3_k127_3631815_7	158189.SpiBuddy_2623	5.158e-73	255.0	COG1653@1|root,COG1653@2|Bacteria,2J66Q@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Bacterial extracellular solute-binding	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_1,SBP_bac_8
SX3_k127_3631815_6	1382304.JNIL01000001_gene3260	2.43e-104	351.0	COG4225@1|root,COG4225@2|Bacteria,1TRJ7@1239|Firmicutes,4HDRZ@91061|Bacilli	91061|Bacilli	G	Glycosyl Hydrolase Family 88	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_88
SX3_k127_3631815_4	1121335.Clst_0909	3.514e-141	463.0	COG5434@1|root,COG5434@2|Bacteria,1TQQW@1239|Firmicutes,24A0R@186801|Clostridia,3WI0S@541000|Ruminococcaceae	186801|Clostridia	M	Belongs to the glycosyl hydrolase 28 family	-	-	3.2.1.67	ko:K01213	ko00040,ko01100,map00040,map01100	M00081	R01982,R07413	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_28,Pectate_lyase_3
SX3_k127_3631815_3	452637.Oter_1254	4.883e-154	498.0	COG0519@1|root,COG0519@2|Bacteria,46SIW@74201|Verrucomicrobia,3K77S@414999|Opitutae	2|Bacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
SX3_k127_3631815_8	744872.Spica_0292	5.727e-71	258.0	COG5522@1|root,COG5522@2|Bacteria	2|Bacteria	S	Integral membrane protein (intg_mem_TP0381)	ywaF	-	-	-	-	-	-	-	-	-	-	-	Intg_mem_TP0381
SX3_k127_3631815_2	889378.Spiaf_2551	2.701e-173	557.0	COG0147@1|root,COG0147@2|Bacteria,2J5PF@203691|Spirochaetes	203691|Spirochaetes	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
SX3_k127_3631815_1	665571.STHERM_c01820	1.53e-183	595.0	COG0512@1|root,COG0547@1|root,COG0512@2|Bacteria,COG0547@2|Bacteria,2J59H@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase,Glycos_trans_3N,Glycos_transf_3
SX3_k127_3631815_5	1480694.DC28_10225	4.117e-141	468.0	COG0134@1|root,COG0135@1|root,COG0134@2|Bacteria,COG0135@2|Bacteria,2J5XH@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the	trpF	-	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS,PRAI
SX3_k127_3631815_0	665571.STHERM_c01840	5.472e-184	582.0	COG0133@1|root,COG0133@2|Bacteria,2J5J8@203691|Spirochaetes	203691|Spirochaetes	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SX3_k127_3631815_10	665571.STHERM_c01850	8.417e-64	228.0	COG0159@1|root,COG0159@2|Bacteria,2J6HT@203691|Spirochaetes	203691|Spirochaetes	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
SX3_k127_3631815_9	665571.STHERM_c19120	3.061e-67	249.0	COG1744@1|root,COG1744@2|Bacteria,2J7UH@203691|Spirochaetes	203691|Spirochaetes	S	Membrane protein, bmp family	-	-	-	ko:K02058,ko:K07335	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
SX3_k127_3631815_11	243231.GSU0751	1.677e-63	228.0	COG5423@1|root,COG5423@2|Bacteria,1N9C0@1224|Proteobacteria,42W42@68525|delta/epsilon subdivisions,2WR81@28221|Deltaproteobacteria,43TPZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Predicted metal-binding protein (DUF2284)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2284
SX3_k127_3634027_22	1499967.BAYZ01000177_gene5701	4.365e-39	147.0	COG2407@1|root,COG2407@2|Bacteria,2NRQW@2323|unclassified Bacteria	2|Bacteria	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3634027_15	401053.AciPR4_1445	5.629e-86	301.0	COG2159@1|root,COG2159@2|Bacteria,3Y2HY@57723|Acidobacteria,2JI2D@204432|Acidobacteriia	204432|Acidobacteriia	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
SX3_k127_3634027_10	411902.CLOBOL_00982	1.81e-118	389.0	COG0363@1|root,COG0363@2|Bacteria,1TQK7@1239|Firmicutes,24CQ8@186801|Clostridia,220RJ@1506553|Lachnoclostridium	186801|Clostridia	G	Psort location Cytoplasmic, score 8.87	-	-	3.5.99.6	ko:K02564	ko00520,ko01100,map00520,map01100	-	R00765	RC00163	ko00000,ko00001,ko01000	-	-	-	-
SX3_k127_3634027_20	411902.CLOBOL_00983	3.943e-47	184.0	COG0524@1|root,COG0524@2|Bacteria,1UE91@1239|Firmicutes,25J4A@186801|Clostridia,222UZ@1506553|Lachnoclostridium	186801|Clostridia	H	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
SX3_k127_3634027_11	1499967.BAYZ01000027_gene1816	1.861e-115	386.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	malE	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
SX3_k127_3634027_12	1499967.BAYZ01000027_gene1817	1.162e-106	353.0	COG1175@1|root,COG1175@2|Bacteria,2NQXK@2323|unclassified Bacteria	2|Bacteria	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025,ko:K15771	ko02010,map02010	M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
SX3_k127_3634027_13	1499967.BAYZ01000027_gene1818	1.164e-91	322.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	malG	-	-	ko:K02025,ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX3_k127_3634027_23	1121468.AUBR01000028_gene1506	5.886e-39	156.0	COG1149@1|root,COG1149@2|Bacteria,1VDSQ@1239|Firmicutes,24NTS@186801|Clostridia	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
SX3_k127_3634027_16	765420.OSCT_0273	3.314e-83	289.0	COG0451@1|root,COG0451@2|Bacteria,2GAZF@200795|Chloroflexi,374ZI@32061|Chloroflexia	32061|Chloroflexia	M	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	3Beta_HSD
SX3_k127_3634027_26	324925.Ppha_1113	3.465e-08	61.0	2ESXY@1|root,33KG8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3634027_24	671143.DAMO_0954	1.432e-31	133.0	COG2250@1|root,COG2250@2|Bacteria,2NRY0@2323|unclassified Bacteria	2|Bacteria	S	Higher Eukarytoes and Prokaryotes Nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
SX3_k127_3634027_8	592015.HMPREF1705_00887	1.893e-129	426.0	COG0683@1|root,COG0683@2|Bacteria	2|Bacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01997,ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
SX3_k127_3634027_9	891968.Anamo_0976	2.613e-128	416.0	COG0559@1|root,COG0559@2|Bacteria,3TACI@508458|Synergistetes	508458|Synergistetes	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
SX3_k127_3634027_7	891968.Anamo_0975	3.364e-133	431.0	COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,3TAPS@508458|Synergistetes	508458|Synergistetes	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
SX3_k127_3634027_14	891968.Anamo_0975	6.755e-88	297.0	COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,3TAPS@508458|Synergistetes	508458|Synergistetes	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
SX3_k127_3634027_17	1121468.AUBR01000023_gene2753	1.708e-80	278.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia,42EMQ@68295|Thermoanaerobacterales	186801|Clostridia	E	ABC transporter related	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
SX3_k127_3634027_5	671143.DAMO_0421	1.193e-158	509.0	COG0513@1|root,COG0513@2|Bacteria,2NP0A@2323|unclassified Bacteria	2|Bacteria	JKL	Belongs to the DEAD box helicase family	rhlE	-	3.6.4.13	ko:K03732,ko:K05592,ko:K11927	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	DEAD,Helicase_C
SX3_k127_3634027_3	1499967.BAYZ01000188_gene3895	2.547e-175	559.0	COG0624@1|root,COG0624@2|Bacteria,2NNX2@2323|unclassified Bacteria	2|Bacteria	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
SX3_k127_3634027_1	1123274.KB899409_gene554	1.339e-275	871.0	COG1529@1|root,COG1529@2|Bacteria,2J59A@203691|Spirochaetes	203691|Spirochaetes	C	Aldehyde oxidase and xanthine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
SX3_k127_3634027_18	573413.Spirs_1390	2.702e-61	218.0	COG2080@1|root,COG2080@2|Bacteria,2J812@203691|Spirochaetes	203691|Spirochaetes	C	Aerobic-type carbon monoxide dehydrogenase small subunit CoxS	coxS	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
SX3_k127_3634027_19	748727.CLJU_c29920	2.494e-54	202.0	COG1319@1|root,COG1319@2|Bacteria,1TQA5@1239|Firmicutes,248WI@186801|Clostridia,36DQR@31979|Clostridiaceae	186801|Clostridia	C	Molybdopterin dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	iHN637.CLJU_RS14760	CO_deh_flav_C,FAD_binding_5
SX3_k127_3634027_2	1123274.KB899409_gene551	1.718e-184	592.0	COG0402@1|root,COG0402@2|Bacteria,2J6KS@203691|Spirochaetes	203691|Spirochaetes	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
SX3_k127_3634027_4	1123274.KB899414_gene3738	5.237e-166	554.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,2JBGS@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,NUDIX,PAS_4,Response_reg
SX3_k127_3634027_21	744872.Spica_1705	1.518e-42	159.0	COG0760@1|root,COG0760@2|Bacteria,2J7Z8@203691|Spirochaetes	203691|Spirochaetes	O	peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3
SX3_k127_3634027_25	1540221.JQNI01000004_gene258	1.034e-15	87.0	COG4630@1|root,COG4630@2|Bacteria,1WM3H@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Xanthine dehydrogenase iron-sulfur cluster and FAD-binding subunit A	-	-	1.17.1.4	ko:K13481	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5,Fer2,Fer2_2
SX3_k127_3634027_0	1123274.KB899409_gene549	0.0	1206.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,2JA0V@203691|Spirochaetes	203691|Spirochaetes	C	xanthine dehydrogenase, a b hammerhead	-	-	-	ko:K12528	ko00450,map00450	-	R07229	RC02420	ko00000,ko00001	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2_2
SX3_k127_3634027_6	158190.SpiGrapes_3159	1.49e-158	525.0	COG0078@1|root,COG0078@2|Bacteria,2J5Q3@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the ATCase OTCase family	ygeW	-	-	-	-	-	-	-	-	-	-	-	OTCace,OTCace_N
SX3_k127_3634027_27	69014.TK0557	3.106e-07	59.0	COG1618@1|root,arCOG01034@2157|Archaea,2XX6U@28890|Euryarchaeota,242ZH@183968|Thermococci	183968|Thermococci	F	Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency	-	-	3.6.1.15	ko:K06928	ko00230,ko00730,ko01100,map00230,map00730,map01100	-	R00086,R00615	RC00002	ko00000,ko00001,ko01000	-	-	-	NTPase_1
SX3_k127_3634027_28	2055.JNXA01000003_gene4424	1.003e-05	54.0	COG4307@1|root,COG4307@2|Bacteria,2GKD6@201174|Actinobacteria,4GBWS@85026|Gordoniaceae	201174|Actinobacteria	S	zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_Mx,zinc-ribbon_6
SX3_k127_3635692_59	880073.Calab_0676	6.883e-12	75.0	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,2NP45@2323|unclassified Bacteria	2|Bacteria	M	Patatin-like phospholipase	plpD	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,POTRA,Patatin
SX3_k127_3635692_19	760011.Spico_0967	8.937e-92	306.0	COG0572@1|root,COG0572@2|Bacteria,2J6XC@203691|Spirochaetes	203691|Spirochaetes	F	Cytidine monophosphokinase	udk	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
SX3_k127_3635692_41	660470.Theba_1369	5.406e-59	209.0	COG0386@1|root,COG0386@2|Bacteria	2|Bacteria	O	Belongs to the glutathione peroxidase family	btuE	-	1.11.1.22,1.11.1.9	ko:K00432,ko:K20207	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	iJN678.slr1992	GSHPx
SX3_k127_3635692_16	1321778.HMPREF1982_01563	2.436e-107	356.0	COG0508@1|root,COG0508@2|Bacteria,1V9QA@1239|Firmicutes,24KV2@186801|Clostridia	186801|Clostridia	C	dehydrogenase complex catalyzes the overall conversion of	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3635692_23	1365176.N186_01470	5.88e-88	307.0	COG0399@1|root,arCOG00118@2157|Archaea,2XQAK@28889|Crenarchaeota	28889|Crenarchaeota	E	Belongs to the DegT DnrJ EryC1 family	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
SX3_k127_3635692_28	28444.JODQ01000001_gene2386	2.502e-78	274.0	COG1879@1|root,COG1879@2|Bacteria,2I8KH@201174|Actinobacteria,4EM9C@85012|Streptosporangiales	201174|Actinobacteria	G	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
SX3_k127_3635692_8	1123075.AUDP01000048_gene1557	6.225e-150	490.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,3WMVK@541000|Ruminococcaceae	186801|Clostridia	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K10539	ko02010,map02010	M00213	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.2	-	-	ABC_tran
SX3_k127_3635692_34	537013.CLOSTMETH_03785	1.573e-72	263.0	COG1172@1|root,COG1172@2|Bacteria,1VW6R@1239|Firmicutes,2516G@186801|Clostridia,3WP5M@541000|Ruminococcaceae	186801|Clostridia	G	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
SX3_k127_3635692_27	537013.CLOSTMETH_03784	4.416e-79	275.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,249FA@186801|Clostridia,3WPIC@541000|Ruminococcaceae	186801|Clostridia	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
SX3_k127_3635692_10	632518.Calow_2148	1.045e-140	456.0	COG0407@1|root,COG0407@2|Bacteria,1UY51@1239|Firmicutes,24DZF@186801|Clostridia,42FW9@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_3635692_40	485917.Phep_2431	8.704e-60	223.0	COG2207@1|root,COG2207@2|Bacteria,4NMFW@976|Bacteroidetes,1IUWY@117747|Sphingobacteriia	976|Bacteroidetes	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18,HTH_AraC
SX3_k127_3635692_3	589865.DaAHT2_1713	4.117e-255	806.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,42N5M@68525|delta/epsilon subdivisions,2WIIV@28221|Deltaproteobacteria,2MJ3W@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM aconitate hydratase	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2763	Aconitase,Aconitase_C
SX3_k127_3635692_43	1123274.KB899407_gene237	1.048e-53	198.0	COG1259@1|root,COG1259@2|Bacteria,2J813@203691|Spirochaetes	203691|Spirochaetes	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase,UVR
SX3_k127_3635692_18	545695.TREAZ_2335	1.919e-100	340.0	COG1313@1|root,COG1313@2|Bacteria,2J68B@203691|Spirochaetes	203691|Spirochaetes	C	Radical SAM domain protein	pflX	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
SX3_k127_3635692_32	545695.TREAZ_0774	3.734e-75	274.0	COG0528@1|root,COG0528@2|Bacteria,2J5H9@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
SX3_k127_3635692_22	1380394.JADL01000004_gene6037	1.023e-88	302.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,2TR0F@28211|Alphaproteobacteria,2JPYH@204441|Rhodospirillales	204441|Rhodospirillales	EH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
SX3_k127_3635692_49	203119.Cthe_1305	6.095e-36	139.0	COG0662@1|root,COG0662@2|Bacteria,1UI0P@1239|Firmicutes,24SCP@186801|Clostridia,3WQJK@541000|Ruminococcaceae	186801|Clostridia	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SX3_k127_3635692_12	1123274.KB899410_gene3538	2.303e-135	460.0	COG0457@1|root,COG0457@2|Bacteria,2J6MS@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_8
SX3_k127_3635692_42	744872.Spica_0460	7.808e-54	200.0	COG2834@1|root,COG2834@2|Bacteria,2J7JX@203691|Spirochaetes	203691|Spirochaetes	M	PFAM Outer membrane lipoprotein carrier protein LolA	-	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
SX3_k127_3635692_38	744872.Spica_0461	7.195e-61	224.0	COG1426@1|root,COG1426@2|Bacteria,2J61E@203691|Spirochaetes	203691|Spirochaetes	S	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_25
SX3_k127_3635692_14	545694.TREPR_1193	4.659e-125	419.0	COG0621@1|root,COG0621@2|Bacteria,2J5PM@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
SX3_k127_3635692_6	889378.Spiaf_0658	8.036e-202	651.0	COG0210@1|root,COG0210@2|Bacteria,2J5EW@203691|Spirochaetes	203691|Spirochaetes	L	DNA helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
SX3_k127_3635692_24	443143.GM18_4141	9.648e-86	297.0	COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,42N4U@68525|delta/epsilon subdivisions,2WJR7@28221|Deltaproteobacteria,43TUX@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Converts GTP to 7,8-dihydroneopterin triphosphate	folE2	-	3.5.4.16	ko:K09007	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GCHY-1
SX3_k127_3635692_53	158190.SpiGrapes_2616	4.021e-22	107.0	COG0001@1|root,COG0001@2|Bacteria	2|Bacteria	H	glutamate-1-semialdehyde 2,1-aminomutase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3635692_52	518766.Rmar_2791	1.315e-27	130.0	COG0363@1|root,COG2120@1|root,COG0363@2|Bacteria,COG2120@2|Bacteria,4NDUN@976|Bacteroidetes,1FJY4@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	nagB	-	3.5.99.6	ko:K02564	ko00520,ko01100,map00520,map01100	-	R00765	RC00163	ko00000,ko00001,ko01000	-	-	-	Glucosamine_iso,PIG-L
SX3_k127_3635692_58	247490.KSU1_B0122	7.676e-13	70.0	2DU2S@1|root,33NPR@2|Bacteria,2J4AF@203682|Planctomycetes	203682|Planctomycetes	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_13
SX3_k127_3635692_54	744872.Spica_0466	5.474e-20	92.0	28WC9@1|root,2ZICM@2|Bacteria,2J8XW@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3635692_39	744872.Spica_0467	7.723e-61	212.0	COG0102@1|root,COG0102@2|Bacteria,2J7C1@203691|Spirochaetes	203691|Spirochaetes	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
SX3_k127_3635692_47	573413.Spirs_3752	2.5e-46	171.0	COG0103@1|root,COG0103@2|Bacteria,2J8A0@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
SX3_k127_3635692_56	479434.Sthe_1432	1.228e-14	82.0	COG2137@1|root,COG2137@2|Bacteria,2G6WA@200795|Chloroflexi,27YM4@189775|Thermomicrobia	189775|Thermomicrobia	S	RecX family	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
SX3_k127_3635692_51	573413.Spirs_2126	3.068e-29	125.0	COG2454@1|root,COG2454@2|Bacteria,2JADQ@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF434)	-	-	-	-	-	-	-	-	-	-	-	-	DUF434
SX3_k127_3635692_33	744872.Spica_0470	7.485e-75	257.0	COG0745@1|root,COG0745@2|Bacteria,2J7NK@203691|Spirochaetes	203691|Spirochaetes	T	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,Response_reg
SX3_k127_3635692_46	1123274.KB899410_gene3550	1.399e-47	175.0	COG2204@1|root,COG2204@2|Bacteria,2JAI3@203691|Spirochaetes	203691|Spirochaetes	T	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
SX3_k127_3635692_55	545694.TREPR_0734	8.226e-19	89.0	COG1254@1|root,COG1254@2|Bacteria,2J94Q@203691|Spirochaetes	203691|Spirochaetes	C	Acylphosphatase	-	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
SX3_k127_3635692_30	987059.RBXJA2T_10971	6.457e-77	276.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	cpdA	-	-	-	-	-	-	-	-	-	-	-	Metallophos
SX3_k127_3635692_5	1519464.HY22_02080	6.899e-205	655.0	COG0449@1|root,COG0449@2|Bacteria,1FDCR@1090|Chlorobi	1090|Chlorobi	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
SX3_k127_3635692_17	530564.Psta_0489	6.829e-103	351.0	COG1207@1|root,COG1207@2|Bacteria,2IXBV@203682|Planctomycetes	203682|Planctomycetes	M	Sugar nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_4
SX3_k127_3635692_50	1173028.ANKO01000044_gene791	1.875e-30	138.0	COG3393@1|root,COG3393@2|Bacteria	2|Bacteria	S	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,FR47,GNAT_acetyltran
SX3_k127_3635692_44	1304284.L21TH_0785	4.296e-53	195.0	COG5522@1|root,COG5522@2|Bacteria,1V4XE@1239|Firmicutes,24Q8V@186801|Clostridia,36KVT@31979|Clostridiaceae	186801|Clostridia	S	Integral membrane protein (intg_mem_TP0381)	-	-	-	-	-	-	-	-	-	-	-	-	Intg_mem_TP0381
SX3_k127_3635692_25	357808.RoseRS_4039	1.369e-85	312.0	COG0784@1|root,COG2203@1|root,COG3852@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2203@2|Bacteria,COG3852@2|Bacteria,COG4191@2|Bacteria,2G7PG@200795|Chloroflexi,3762S@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,HisKA_7TM,PAS_4,PAS_8,Response_reg
SX3_k127_3635692_57	517418.Ctha_1881	1.919e-13	81.0	COG0737@1|root,COG0737@2|Bacteria,1FF8Y@1090|Chlorobi	1090|Chlorobi	F	Belongs to the 5'-nucleotidase family	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3635692_15	1210884.HG799472_gene14857	5.07e-120	393.0	COG0667@1|root,COG0667@2|Bacteria,2IX8H@203682|Planctomycetes	203682|Planctomycetes	C	oxidoreductases (related to aryl-alcohol	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SX3_k127_3635692_20	926569.ANT_12900	3.019e-91	321.0	COG0683@1|root,COG0683@2|Bacteria,2G6Q1@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
SX3_k127_3635692_0	1191523.MROS_1835	0.0	1287.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria	2|Bacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
SX3_k127_3635692_37	665571.STHERM_c12280	6.089e-65	239.0	COG0738@1|root,COG0738@2|Bacteria,2J7KW@203691|Spirochaetes	203691|Spirochaetes	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX3_k127_3635692_45	933262.AXAM01000034_gene1574	6.016e-51	186.0	COG2109@1|root,COG2109@2|Bacteria,1MUN6@1224|Proteobacteria,42RPD@68525|delta/epsilon subdivisions,2WNI0@28221|Deltaproteobacteria,2MK1B@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
SX3_k127_3635692_26	552811.Dehly_1194	1.566e-81	276.0	COG1592@1|root,COG1592@2|Bacteria	2|Bacteria	C	Rubrerythrin	rbr	GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
SX3_k127_3635692_1	1304885.AUEY01000007_gene1363	0.0	1225.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2MIP0@213118|Desulfobacterales	28221|Deltaproteobacteria	I	BadF BadG BcrA BcrD	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
SX3_k127_3635692_13	1123274.KB899412_gene1498	4.776e-131	432.0	COG0771@1|root,COG0771@2|Bacteria,2J5IW@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
SX3_k127_3635692_21	665571.STHERM_c03320	7.736e-90	306.0	2EYH2@1|root,33RQY@2|Bacteria,2J9M4@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3635692_2	665571.STHERM_c21600	2.003e-301	936.0	COG1274@1|root,COG1274@2|Bacteria,2J5BB@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
SX3_k127_3635692_4	706587.Desti_3602	2.366e-224	707.0	COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,42Y69@68525|delta/epsilon subdivisions,2WJ5F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,Sigma54_activat
SX3_k127_3635692_11	573413.Spirs_1023	1.064e-138	452.0	COG0436@1|root,COG0436@2|Bacteria,2J5R0@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
SX3_k127_3635692_9	903818.KI912268_gene2682	2.337e-144	465.0	COG1897@1|root,COG1897@2|Bacteria,3Y6RE@57723|Acidobacteria	57723|Acidobacteria	E	Homoserine O-succinyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	HTS
SX3_k127_3635692_48	744872.Spica_2384	2.807e-39	151.0	2AMDJ@1|root,31C90@2|Bacteria,2J6DK@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3635692_31	665571.STHERM_c02000	8.399e-77	270.0	COG1242@1|root,COG1242@2|Bacteria,2J6Y8@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM radical SAM protein, TIGR01212 family	-	-	-	ko:K07139	-	-	-	-	ko00000	-	-	-	Radical_SAM,Radical_SAM_C
SX3_k127_3635692_29	545694.TREPR_3045	4.221e-78	281.0	COG1653@1|root,COG1653@2|Bacteria,2J5NC@203691|Spirochaetes	203691|Spirochaetes	G	transport	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
SX3_k127_3635692_7	1307761.L21SP2_0211	1.054e-170	542.0	COG3842@1|root,COG3842@2|Bacteria,2J5T3@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
SX3_k127_3635692_35	1480694.DC28_10280	1.004e-70	252.0	COG3712@1|root,COG3712@2|Bacteria,2J9H5@203691|Spirochaetes	203691|Spirochaetes	PT	iron ion homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	FecR
SX3_k127_3638001_32	1121405.dsmv_1803	5.683e-20	93.0	2EB38@1|root,33540@2|Bacteria,1NBMZ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3638001_37	314230.DSM3645_29906	8.879e-05	48.0	COG0286@1|root,COG0286@2|Bacteria,2IXMQ@203682|Planctomycetes	203682|Planctomycetes	V	type I restriction-modification system	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
SX3_k127_3638001_35	426368.MmarC7_0019	7.615e-07	54.0	COG0286@1|root,arCOG02632@2157|Archaea,2XUMY@28890|Euryarchaeota,23QI6@183939|Methanococci	183939|Methanococci	L	PFAM N-6 DNA methylase	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
SX3_k127_3638001_33	204669.Acid345_3757	2e-14	76.0	COG0732@1|root,COG0732@2|Bacteria,3Y5Z8@57723|Acidobacteria,2JK6J@204432|Acidobacteriia	204432|Acidobacteriia	V	Type I restriction modification DNA specificity domain	-	-	3.1.21.3	ko:K01154	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Methylase_S
SX3_k127_3638001_26	227377.CBU_1788	2.593e-36	145.0	COG0449@1|root,COG0449@2|Bacteria,1RGWX@1224|Proteobacteria,1SPE9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	ORF6N domain	-	-	-	-	-	-	-	-	-	-	-	-	ORF6N
SX3_k127_3638001_13	1242864.D187_005013	5.287e-67	241.0	COG4823@1|root,COG4823@2|Bacteria,1NJIX@1224|Proteobacteria,42ZG0@68525|delta/epsilon subdivisions	1224|Proteobacteria	V	Abortive infection bacteriophage resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	Abi_2
SX3_k127_3638001_19	1122223.KB890687_gene2605	5.86e-56	199.0	COG0286@1|root,COG0286@2|Bacteria,1WJAF@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	V	HsdM N-terminal domain	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
SX3_k127_3638001_36	292564.Cyagr_1942	3.667e-05	52.0	COG1522@1|root,COG2865@1|root,COG1522@2|Bacteria,COG2865@2|Bacteria,1G3CY@1117|Cyanobacteria	1117|Cyanobacteria	K	PFAM Divergent AAA domain	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4
SX3_k127_3638001_18	665571.STHERM_c14880	4.827e-58	218.0	COG0170@1|root,COG0344@1|root,COG0170@2|Bacteria,COG0344@2|Bacteria	2|Bacteria	I	acyl-phosphate glycerol-3-phosphate acyltransferase activity	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
SX3_k127_3638001_22	502558.EGYY_08570	1.381e-44	178.0	COG1533@1|root,COG1533@2|Bacteria,2GM31@201174|Actinobacteria	201174|Actinobacteria	L	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SX3_k127_3638001_16	1499967.BAYZ01000014_gene6411	1.366e-65	245.0	COG0407@1|root,COG0407@2|Bacteria,2NPIC@2323|unclassified Bacteria	2|Bacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
SX3_k127_3638001_20	929712.KI912613_gene1424	7.727e-48	186.0	COG0451@1|root,COG0451@2|Bacteria,2GMHH@201174|Actinobacteria,4CR2C@84995|Rubrobacteria	84995|Rubrobacteria	M	Male sterility protein	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
SX3_k127_3638001_3	926550.CLDAP_06320	1.159e-139	460.0	COG0667@1|root,COG0667@2|Bacteria,2G5YU@200795|Chloroflexi	200795|Chloroflexi	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SX3_k127_3638001_2	880073.Calab_2841	7.012e-171	556.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
SX3_k127_3638001_21	1499967.BAYZ01000095_gene4055	8.014e-47	186.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	2.3.1.82	ko:K18815	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
SX3_k127_3638001_6	1499967.BAYZ01000095_gene4057	6.086e-92	313.0	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlA	-	6.3.2.4,6.3.5.5	ko:K01921,ko:K01955	ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502	M00051	R00256,R00575,R01150,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
SX3_k127_3638001_1	1499967.BAYZ01000028_gene1265	9.899e-178	569.0	COG1509@1|root,COG1509@2|Bacteria,2NNY6@2323|unclassified Bacteria	2|Bacteria	E	lysine 2,3-aminomutase activity	kamA	-	5.4.3.2	ko:K01843,ko:K19810	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000,ko03012	-	-	-	Fer4_12,Fer4_14,LAM_C,Radical_SAM
SX3_k127_3638001_15	1227352.C173_02979	1.639e-66	246.0	COG2081@1|root,COG2081@2|Bacteria,1TQ6E@1239|Firmicutes,4HAAT@91061|Bacilli,26QHR@186822|Paenibacillaceae	91061|Bacilli	S	HI0933-like protein	ytfP	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
SX3_k127_3638001_4	1128421.JAGA01000003_gene3269	2.379e-119	397.0	COG2262@1|root,COG2262@2|Bacteria,2NNWI@2323|unclassified Bacteria	2|Bacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
SX3_k127_3638001_9	1499967.BAYZ01000131_gene356	4.121e-86	293.0	COG1129@1|root,COG1129@2|Bacteria,2NPR8@2323|unclassified Bacteria	2|Bacteria	G	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran,HATPase_c,HisKA
SX3_k127_3638001_8	990285.RGCCGE502_21060	3.036e-91	311.0	COG1129@1|root,COG1172@1|root,COG1129@2|Bacteria,COG1172@2|Bacteria,1NSFE@1224|Proteobacteria,2UQJT@28211|Alphaproteobacteria,4BBUH@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
SX3_k127_3638001_12	1040982.AXAL01000002_gene5668	2.141e-73	254.0	COG1879@1|root,COG1879@2|Bacteria,1MV17@1224|Proteobacteria,2U8PP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Periplasmic binding protein domain	-	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Peripla_BP_4
SX3_k127_3638001_34	1499967.BAYZ01000131_gene355	8.987e-10	62.0	COG1879@1|root,COG1879@2|Bacteria	2|Bacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K02058,ko:K10439	ko02010,ko02030,map02010,map02030	M00212,M00221	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
SX3_k127_3638001_5	748449.Halha_2501	1.693e-98	332.0	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia	186801|Clostridia	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
SX3_k127_3638001_10	545694.TREPR_0400	1.808e-80	276.0	COG4130@1|root,COG4130@2|Bacteria,2J8DR@203691|Spirochaetes	203691|Spirochaetes	G	Xylose isomerase domain protein TIM barrel	-	-	5.3.99.11	ko:K06606	ko00562,ko01120,map00562,map01120	-	R09952	RC01513	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
SX3_k127_3638001_31	525898.Sdel_0655	2.331e-21	111.0	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,42USK@68525|delta/epsilon subdivisions,2YPZR@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
SX3_k127_3638001_38	1502852.FG94_01283	0.000611	46.0	COG0500@1|root,COG2226@2|Bacteria,1QWP0@1224|Proteobacteria	1224|Proteobacteria	Q	Putative methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
SX3_k127_3638001_23	1499967.BAYZ01000167_gene6735	2.101e-39	157.0	COG0454@1|root,COG0456@2|Bacteria,2NS1J@2323|unclassified Bacteria	2|Bacteria	K	FR47-like protein	argO	-	2.3.1.1	ko:K03826,ko:K22477	ko00220,ko01210,ko01230,map00220,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10
SX3_k127_3638001_27	1192034.CAP_5333	9.467e-35	141.0	COG4430@1|root,COG4430@2|Bacteria,1NEN6@1224|Proteobacteria,4386R@68525|delta/epsilon subdivisions,2X9ZT@28221|Deltaproteobacteria,2YUYI@29|Myxococcales	28221|Deltaproteobacteria	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
SX3_k127_3638001_14	1158606.I579_01824	6.802e-67	241.0	COG2017@1|root,COG2017@2|Bacteria,1U26T@1239|Firmicutes,4HA4J@91061|Bacilli,4AZ8Q@81852|Enterococcaceae	91061|Bacilli	G	Aldose 1-epimerase	-	-	-	-	-	-	-	-	-	-	-	-	Aldose_epim
SX3_k127_3638001_11	1121405.dsmv_2769	5.469e-80	272.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,42NC0@68525|delta/epsilon subdivisions,2WJK9@28221|Deltaproteobacteria,2MHRY@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
SX3_k127_3638001_7	1499967.BAYZ01000013_gene6425	2.152e-91	316.0	COG0274@1|root,COG0274@2|Bacteria,2NP8Z@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	2.7.1.15,4.1.2.4	ko:K00852,ko:K01619	ko00030,map00030	-	R01051,R01066,R02750	RC00002,RC00017,RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
SX3_k127_3638001_17	1499967.BAYZ01000013_gene6424	1.181e-62	218.0	COG0698@1|root,COG0698@2|Bacteria,2NPF4@2323|unclassified Bacteria	2|Bacteria	G	ribose 5-phosphate isomerase B	upp	-	2.4.2.9,5.3.1.6	ko:K00761,ko:K01808	ko00030,ko00051,ko00240,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00240,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R00966,R01056,R09030	RC00063,RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB,UPRTase
SX3_k127_3638001_29	1499967.BAYZ01000013_gene6423	1.536e-22	102.0	COG4576@1|root,COG4576@2|Bacteria,2NS06@2323|unclassified Bacteria	2|Bacteria	CQ	Ethanolamine utilisation protein EutN/carboxysome	eutN	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716	-	ko:K04028	-	-	-	-	ko00000	-	-	-	EutN_CcmL
SX3_k127_3638001_28	1499967.BAYZ01000013_gene6422	3.499e-27	112.0	COG4576@1|root,COG4576@2|Bacteria,2NRYU@2323|unclassified Bacteria	2|Bacteria	CQ	Ethanolamine utilisation protein EutN/carboxysome	eutN	-	-	ko:K04028	-	-	-	-	ko00000	-	-	-	EutN_CcmL
SX3_k127_3638001_0	1499967.BAYZ01000013_gene6421	4.861e-186	592.0	COG1012@1|root,COG1012@2|Bacteria,2NQI9@2323|unclassified Bacteria	2|Bacteria	C	Aldehyde dehydrogenase family	eutE	GO:0003674,GO:0003824,GO:0004029,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.87	ko:K04021,ko:K13922	ko00620,ko00640,ko01100,ko01120,map00620,map00640,map01100,map01120	-	R00228,R09097	RC00004,RC00184,RC01195	ko00000,ko00001,ko01000	-	-	-	Aldedh
SX3_k127_3638001_30	1499967.BAYZ01000013_gene6420	5.596e-22	103.0	COG4576@1|root,COG4576@2|Bacteria	2|Bacteria	CQ	ethanolamine utilization protein EutN carboxysome structural protein Ccml	-	-	-	ko:K04028	-	-	-	-	ko00000	-	-	-	EutN_CcmL
SX3_k127_3638001_25	1499967.BAYZ01000013_gene6419	1.315e-36	141.0	COG4576@1|root,COG4576@2|Bacteria,2NRNV@2323|unclassified Bacteria	2|Bacteria	CQ	Ethanolamine utilisation protein EutN/carboxysome	-	-	-	ko:K04028,ko:K08697	-	-	-	-	ko00000	-	-	-	EutN_CcmL
SX3_k127_3638001_24	1499967.BAYZ01000012_gene2485	2.761e-39	148.0	COG4577@1|root,COG4577@2|Bacteria,2NRBW@2323|unclassified Bacteria	2|Bacteria	CQ	COGs COG4577 Carbon dioxide concentrating mechanism carboxysome shell protein	-	-	-	ko:K04027	-	-	-	-	ko00000	-	-	-	BMC
SX3_k127_3697244_7	180332.JTGN01000001_gene4749	2.798e-39	162.0	COG2407@1|root,COG2407@2|Bacteria	2|Bacteria	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	Fucose_iso_C
SX3_k127_3697244_3	180332.JTGN01000001_gene4745	4.749e-96	329.0	COG1653@1|root,COG1653@2|Bacteria,1W04F@1239|Firmicutes,2543W@186801|Clostridia	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
SX3_k127_3697244_4	180332.JTGN01000001_gene4744	6.58e-92	310.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	ko:K02025,ko:K15771	ko02010,map02010	M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
SX3_k127_3697244_5	180332.JTGN01000001_gene4743	8.38e-67	247.0	COG0395@1|root,COG0395@2|Bacteria,1TPRG@1239|Firmicutes,249S6@186801|Clostridia	1239|Firmicutes	P	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
SX3_k127_3697244_2	545694.TREPR_1522	7.121e-108	362.0	COG0407@1|root,COG0407@2|Bacteria,2J9RK@203691|Spirochaetes	203691|Spirochaetes	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_3697244_0	1122605.KB893637_gene3221	1.563e-196	623.0	COG0160@1|root,COG0160@2|Bacteria,4NIHH@976|Bacteroidetes,1IWIQ@117747|Sphingobacteriia	976|Bacteroidetes	E	COGs COG0160 4-aminobutyrate aminotransferase and related aminotransferase	-	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SX3_k127_3697244_8	1276920.ADIAG_00940	1.368e-29	128.0	COG1349@1|root,COG1349@2|Bacteria,2GMAJ@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K02444	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
SX3_k127_3697244_6	671143.DAMO_0720	1.007e-39	151.0	COG1669@1|root,COG1669@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
SX3_k127_3697244_9	402777.KB235904_gene3669	5.194e-21	96.0	COG2361@1|root,COG2361@2|Bacteria,1GA5P@1117|Cyanobacteria,1HDVY@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
SX3_k127_3697244_1	1123008.KB905694_gene1688	1.254e-124	426.0	COG0210@1|root,COG1379@1|root,COG0210@2|Bacteria,COG1379@2|Bacteria,4NDWN@976|Bacteroidetes,2FNIM@200643|Bacteroidia,22WFT@171551|Porphyromonadaceae	976|Bacteroidetes	L	DNA helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
SX3_k127_3804260_24	1150469.RSPPHO_01286	2.557e-16	84.0	COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,2TQWS@28211|Alphaproteobacteria,2JPAR@204441|Rhodospirillales	204441|Rhodospirillales	E	homoserine dehydrogenase	hom	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
SX3_k127_3804260_10	1121441.AUCX01000008_gene2225	3.435e-68	239.0	COG1387@1|root,COG1387@2|Bacteria,1R9W5@1224|Proteobacteria,42QNF@68525|delta/epsilon subdivisions,2WMV0@28221|Deltaproteobacteria,2M8EF@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	SMART phosphoesterase PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP
SX3_k127_3804260_22	573413.Spirs_1326	4.789e-28	121.0	COG0762@1|root,COG0762@2|Bacteria,2J81F@203691|Spirochaetes	203691|Spirochaetes	S	PFAM YGGT family	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
SX3_k127_3804260_4	573413.Spirs_1325	6.859e-196	631.0	COG1200@1|root,COG1200@2|Bacteria,2J5ET@203691|Spirochaetes	203691|Spirochaetes	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
SX3_k127_3804260_16	760011.Spico_1798	2.518e-50	188.0	COG0742@1|root,COG0742@2|Bacteria,2J7B5@203691|Spirochaetes	203691|Spirochaetes	L	RNA methyltransferase, RsmD family	yhhF	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth95
SX3_k127_3804260_23	243275.TDE_2428	2.416e-20	93.0	COG0267@1|root,COG0267@2|Bacteria,2J8UW@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
SX3_k127_3804260_25	1123274.KB899411_gene3125	6.255e-14	74.0	COG0690@1|root,COG0690@2|Bacteria,2J9CX@203691|Spirochaetes	203691|Spirochaetes	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
SX3_k127_3804260_7	1123274.KB899411_gene3124	1.612e-87	291.0	COG0250@1|root,COG0250@2|Bacteria,2J7FV@203691|Spirochaetes	203691|Spirochaetes	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
SX3_k127_3804260_13	665571.STHERM_c04860	2.204e-62	217.0	COG0080@1|root,COG0080@2|Bacteria,2J7BU@203691|Spirochaetes	203691|Spirochaetes	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
SX3_k127_3804260_6	1480694.DC28_14400	5.891e-97	321.0	COG0081@1|root,COG0081@2|Bacteria,2J5HN@203691|Spirochaetes	203691|Spirochaetes	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
SX3_k127_3804260_19	1480694.DC28_14395	3.622e-44	168.0	COG0244@1|root,COG0244@2|Bacteria,2J74F@203691|Spirochaetes	203691|Spirochaetes	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
SX3_k127_3804260_15	744872.Spica_0378	9.284e-51	182.0	COG0222@1|root,COG0222@2|Bacteria,2J7NX@203691|Spirochaetes	203691|Spirochaetes	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
SX3_k127_3804260_1	573413.Spirs_0949	0.0	1814.0	COG0085@1|root,COG0085@2|Bacteria,2J5JV@203691|Spirochaetes	203691|Spirochaetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
SX3_k127_3804260_0	1480694.DC28_14380	0.0	2149.0	COG0086@1|root,COG0086@2|Bacteria,2J5S7@203691|Spirochaetes	203691|Spirochaetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
SX3_k127_3804260_11	1480694.DC28_14375	1.098e-66	228.0	COG0048@1|root,COG0048@2|Bacteria,2J7NE@203691|Spirochaetes	203691|Spirochaetes	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
SX3_k127_3804260_14	906968.Trebr_2298	3.169e-60	211.0	COG0049@1|root,COG0049@2|Bacteria,2J7TX@203691|Spirochaetes	203691|Spirochaetes	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
SX3_k127_3804260_2	760142.Hipma_1380	1.143e-292	912.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2WIM7@28221|Deltaproteobacteria,2M6MN@213113|Desulfurellales	28221|Deltaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
SX3_k127_3804260_3	744872.Spica_0383	6.452e-206	650.0	COG0050@1|root,COG0050@2|Bacteria,2J5PY@203691|Spirochaetes	203691|Spirochaetes	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
SX3_k127_3804260_17	1480694.DC28_14360	8.876e-49	179.0	COG0051@1|root,COG0051@2|Bacteria,2J7XK@203691|Spirochaetes	203691|Spirochaetes	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
SX3_k127_3804260_9	665571.STHERM_c04960	1.031e-69	242.0	COG0087@1|root,COG0087@2|Bacteria,2J633@203691|Spirochaetes	203691|Spirochaetes	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
SX3_k127_3804260_8	573413.Spirs_0956	4.735e-80	277.0	COG0088@1|root,COG0088@2|Bacteria,2J5NS@203691|Spirochaetes	203691|Spirochaetes	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
SX3_k127_3804260_21	744872.Spica_0387	4.049e-28	126.0	COG0089@1|root,COG0089@2|Bacteria,2J85B@203691|Spirochaetes	203691|Spirochaetes	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
SX3_k127_3804260_5	1307761.L21SP2_0880	2.197e-128	415.0	COG0090@1|root,COG0090@2|Bacteria,2J5G3@203691|Spirochaetes	203691|Spirochaetes	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
SX3_k127_3804260_18	889378.Spiaf_0558	3.974e-48	173.0	COG0185@1|root,COG0185@2|Bacteria,2J8DX@203691|Spirochaetes	203691|Spirochaetes	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
SX3_k127_3804260_20	1307761.L21SP2_0882	3.243e-34	151.0	COG0091@1|root,COG0091@2|Bacteria,2J7KV@203691|Spirochaetes	203691|Spirochaetes	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
SX3_k127_3804260_12	744872.Spica_0391	2.253e-64	224.0	COG0092@1|root,COG0092@2|Bacteria,2J5AK@203691|Spirochaetes	203691|Spirochaetes	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
SX3_k127_3839761_48	273057.SSO0688	3.918e-21	94.0	COG1136@1|root,arCOG00922@2157|Archaea,2XQ2I@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_3839761_50	665571.STHERM_c22450	2.908e-18	98.0	COG4591@1|root,COG4591@2|Bacteria	2|Bacteria	M	lipoprotein localization to outer membrane	-	-	-	ko:K02004,ko:K09808	ko02010,map02010	M00255,M00258	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.125	-	-	FtsX,MacB_PCD
SX3_k127_3839761_37	665571.STHERM_c18100	3.484e-47	186.0	COG0300@1|root,COG0300@2|Bacteria,2J5I8@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
SX3_k127_3839761_38	293826.Amet_1430	4.961e-35	147.0	COG0716@1|root,COG4231@1|root,COG0716@2|Bacteria,COG4231@2|Bacteria,1UH8P@1239|Firmicutes,25PY6@186801|Clostridia,36S1X@31979|Clostridiaceae	186801|Clostridia	C	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3839761_41	1123279.ATUS01000003_gene506	6.818e-34	150.0	COG2234@1|root,COG2234@2|Bacteria,1R2N8@1224|Proteobacteria,1T5U9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3839761_19	1214101.BN159_1654	3.276e-110	368.0	COG5621@1|root,COG5621@2|Bacteria,2GNHM@201174|Actinobacteria	201174|Actinobacteria	S	secreted hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CrtC
SX3_k127_3839761_9	1121405.dsmv_1129	6.544e-178	602.0	COG3852@1|root,COG4191@1|root,COG3852@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2X734@28221|Deltaproteobacteria,2MIC0@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
SX3_k127_3839761_29	635013.TherJR_1682	7.105e-66	240.0	COG1396@1|root,COG1917@1|root,COG1396@2|Bacteria,COG1917@2|Bacteria,1V26G@1239|Firmicutes,24GYR@186801|Clostridia,264B0@186807|Peptococcaceae	186801|Clostridia	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_19,HTH_3
SX3_k127_3839761_1	398512.JQKC01000007_gene1196	5.713e-262	816.0	COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes,25AZ5@186801|Clostridia,3WH41@541000|Ruminococcaceae	186801|Clostridia	I	AMP-dependent synthetase and ligase	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
SX3_k127_3839761_56	716544.wcw_0021	4.122e-10	62.0	COG1826@1|root,COG1826@2|Bacteria,2JGGQ@204428|Chlamydiae	204428|Chlamydiae	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
SX3_k127_3839761_49	266834.SMc02065	1.047e-20	102.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,2TTIX@28211|Alphaproteobacteria,4B7TU@82115|Rhizobiaceae	28211|Alphaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
SX3_k127_3839761_10	1499967.BAYZ01000180_gene4413	3.06e-173	554.0	28IMC@1|root,2Z8MV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3839761_13	1499967.BAYZ01000181_gene4480	7.444e-140	449.0	COG0413@1|root,COG0413@2|Bacteria,2NP1G@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
SX3_k127_3839761_32	1499967.BAYZ01000088_gene5058	1.307e-58	229.0	COG0348@1|root,COG1143@1|root,COG1148@1|root,COG0348@2|Bacteria,COG1143@2|Bacteria,COG1148@2|Bacteria,2NP1X@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S binding domain	napF	-	-	ko:K02572	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_4,Fer4_5,Fer4_6,Fer4_7
SX3_k127_3839761_33	1121918.ARWE01000001_gene1462	2.541e-56	207.0	COG2006@1|root,COG2006@2|Bacteria,1QMGX@1224|Proteobacteria,42PRJ@68525|delta/epsilon subdivisions,2WMFN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
SX3_k127_3839761_31	573413.Spirs_0384	2.14e-62	228.0	COG1028@1|root,COG1028@2|Bacteria	573413.Spirs_0384|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3839761_35	1501391.LG35_03955	1.234e-49	198.0	COG0300@1|root,COG0300@2|Bacteria,4NJUU@976|Bacteroidetes,2G2WV@200643|Bacteroidia	976|Bacteroidetes	S	KR domain	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
SX3_k127_3839761_39	1007103.AFHW01000170_gene2544	5.282e-35	143.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,4INIS@91061|Bacilli,26UFN@186822|Paenibacillaceae	91061|Bacilli	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SX3_k127_3839761_52	767817.Desgi_3318	2.216e-11	75.0	2E77V@1|root,331RK@2|Bacteria,1TSI0@1239|Firmicutes,24T06@186801|Clostridia,2636Y@186807|Peptococcaceae	186801|Clostridia	S	B-box zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3839761_15	1298598.JCM21714_1021	2.723e-119	392.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,4H9Y3@91061|Bacilli,470UR@74385|Gracilibacillus	91061|Bacilli	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
SX3_k127_3839761_16	1242864.D187_008142	1.085e-117	391.0	COG1172@1|root,COG1172@2|Bacteria,1MUM6@1224|Proteobacteria,432WP@68525|delta/epsilon subdivisions,2WXP4@28221|Deltaproteobacteria,2YWA2@29|Myxococcales	28221|Deltaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
SX3_k127_3839761_6	1499967.BAYZ01000016_gene6538	1.54e-189	605.0	COG1129@1|root,COG1129@2|Bacteria,2NPR8@2323|unclassified Bacteria	2|Bacteria	G	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	ytfR	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	iECED1_1282.ECED1_5085	ABC_tran
SX3_k127_3839761_22	358220.C380_10490	5.642e-106	355.0	COG1879@1|root,COG1879@2|Bacteria,1MXJS@1224|Proteobacteria,2VJJZ@28216|Betaproteobacteria,4ACNX@80864|Comamonadaceae	28216|Betaproteobacteria	G	Periplasmic binding protein LacI transcriptional regulator	ytfQ	-	-	ko:K02058,ko:K10439	ko02010,ko02030,map02010,map02030	M00212,M00221	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
SX3_k127_3839761_3	744872.Spica_2215	6.483e-226	718.0	COG1879@1|root,COG1879@2|Bacteria,2J6JD@203691|Spirochaetes	203691|Spirochaetes	G	Periplasmic binding proteins and sugar binding domain of LacI family	-	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Peripla_BP_4
SX3_k127_3839761_21	484770.UFO1_3135	4.629e-108	363.0	COG2169@1|root,COG4753@1|root,COG2169@2|Bacteria,COG4753@2|Bacteria,1UMK7@1239|Firmicutes,4H8VH@909932|Negativicutes	909932|Negativicutes	T	PFAM response regulator receiver	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
SX3_k127_3839761_7	1122947.FR7_3783	7.549e-188	604.0	COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,4H48Z@909932|Negativicutes	909932|Negativicutes	T	Histidine kinase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,His_kinase,dCache_1
SX3_k127_3839761_46	1230342.CTM_07001	2.577e-24	109.0	COG4635@1|root,COG4635@2|Bacteria,1VBP3@1239|Firmicutes,24JC3@186801|Clostridia,36JH5@31979|Clostridiaceae	186801|Clostridia	CH	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
SX3_k127_3839761_53	1121904.ARBP01000009_gene4385	5.932e-11	74.0	2DMY6@1|root,32UCD@2|Bacteria,4NVHX@976|Bacteroidetes,47SQF@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3839761_62	1303518.CCALI_00662	0.000703	42.0	COG0784@1|root,COG4191@1|root,COG5278@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,COG5278@2|Bacteria	2|Bacteria	T	phosphoserine phosphatase activity	-	-	2.7.13.3	ko:K07711	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	CHASE3,HATPase_c,HisKA,HisKA_3,PAS,PAS_4,PAS_9,Response_reg
SX3_k127_3839761_47	1499967.BAYZ01000023_gene259	3.287e-22	98.0	2DR9H@1|root,33ASP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3839761_26	886379.AEWI01000028_gene248	8.84e-85	292.0	COG0846@1|root,COG0846@2|Bacteria,4NE9Q@976|Bacteroidetes,2FWW9@200643|Bacteroidia,3XJI2@558415|Marinilabiliaceae	976|Bacteroidetes	K	Sir2 family	-	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
SX3_k127_3839761_18	573413.Spirs_3940	3.491e-111	381.0	COG2008@1|root,COG2008@2|Bacteria,2J5XX@203691|Spirochaetes	203691|Spirochaetes	E	PFAM aromatic amino acid beta-eliminating lyase threonine aldolase	ltaE	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
SX3_k127_3839761_43	926569.ANT_03650	6.757e-32	131.0	COG0671@1|root,COG0671@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	-	-	3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27	ko:K01096,ko:K19302	ko00550,ko00564,ko01100,map00550,map00564,map01100	-	R02029,R05627	RC00002,RC00017	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
SX3_k127_3839761_2	378806.STAUR_3879	3.118e-234	745.0	COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,42M8J@68525|delta/epsilon subdivisions,2WJD6@28221|Deltaproteobacteria,2YTW8@29|Myxococcales	28221|Deltaproteobacteria	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
SX3_k127_3839761_0	1304880.JAGB01000002_gene2197	6.059e-291	902.0	COG2407@1|root,COG2407@2|Bacteria,1TQ5Q@1239|Firmicutes,248V0@186801|Clostridia	186801|Clostridia	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	fucI	-	5.3.1.25,5.3.1.3	ko:K01818	ko00051,ko01120,map00051,map01120	-	R03163	RC00434	ko00000,ko00001,ko01000	-	-	-	Fucose_iso_C,Fucose_iso_N1,Fucose_iso_N2
SX3_k127_3839761_20	1303518.CCALI_00386	2.478e-109	374.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	-	-	-	ko:K19956	ko00051,map00051	-	R03234	RC00089	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
SX3_k127_3839761_59	471853.Bcav_3316	2.916e-09	68.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SX3_k127_3839761_30	1121468.AUBR01000010_gene2448	3.865e-65	241.0	COG0585@1|root,COG0585@2|Bacteria,1TXVC@1239|Firmicutes,24DVS@186801|Clostridia,42F06@68295|Thermoanaerobacterales	186801|Clostridia	J	PFAM tRNA pseudouridine synthase D TruD	-	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
SX3_k127_3839761_40	885272.JonanDRAFT_1292	5.242e-34	146.0	COG0628@1|root,COG0628@2|Bacteria,3T9W6@508458|Synergistetes	508458|Synergistetes	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
SX3_k127_3839761_34	639282.DEFDS_0706	1.58e-50	192.0	COG0672@1|root,COG0672@2|Bacteria,2GGKP@200930|Deferribacteres	200930|Deferribacteres	P	Iron permease FTR1 family	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1
SX3_k127_3839761_27	744872.Spica_0418	1.052e-78	269.0	COG0517@1|root,COG0517@2|Bacteria,2J6JU@203691|Spirochaetes	203691|Spirochaetes	S	CBS domain	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	ACT,CBS
SX3_k127_3839761_14	385682.AFSL01000053_gene496	1.851e-132	435.0	COG0436@1|root,COG0436@2|Bacteria,4NG6G@976|Bacteroidetes,2FN1B@200643|Bacteroidia,3XJVE@558415|Marinilabiliaceae	976|Bacteroidetes	E	Aminotransferase class I and II	aspC	-	2.6.1.1,2.6.1.2,2.6.1.66	ko:K00812,ko:K14260	ko00220,ko00250,ko00270,ko00290,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00290,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00258,R00355,R00694,R00734,R00896,R01215,R02433,R02619,R05052	RC00006,RC00008,RC00036	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
SX3_k127_3839761_36	1121405.dsmv_0777	6.297e-49	181.0	COG0309@1|root,COG0546@1|root,COG0309@2|Bacteria,COG0546@2|Bacteria,1N04A@1224|Proteobacteria,437IA@68525|delta/epsilon subdivisions,2WYKF@28221|Deltaproteobacteria,2MP0D@213118|Desulfobacterales	28221|Deltaproteobacteria	O	AIR synthase related protein, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AIRS,AIRS_C
SX3_k127_3839761_17	251229.Chro_2859	3.026e-112	382.0	COG0446@1|root,COG2146@1|root,COG0446@2|Bacteria,COG2146@2|Bacteria,1G40A@1117|Cyanobacteria,3VJDA@52604|Pleurocapsales	1117|Cyanobacteria	P	Reductase C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Reductase_C,Rieske
SX3_k127_3839761_61	573413.Spirs_2529	6.599e-06	57.0	2EDJ0@1|root,337EV@2|Bacteria,2JAVQ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3839761_51	768671.ThimaDRAFT_1522	3.543e-16	85.0	2DRNI@1|root,33CD9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3839761_54	555088.DealDRAFT_2728	8.293e-11	72.0	COG4758@1|root,COG4758@2|Bacteria,1UITP@1239|Firmicutes,24NAQ@186801|Clostridia	186801|Clostridia	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154,Toast_rack_N
SX3_k127_3839761_11	880073.Calab_2356	1.301e-153	514.0	COG0574@1|root,COG0574@2|Bacteria,2NQHP@2323|unclassified Bacteria	2|Bacteria	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transf_2,PPDK_N,Response_reg
SX3_k127_3839761_8	335543.Sfum_3244	1.143e-186	593.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NM8@68525|delta/epsilon subdivisions,2WIWB@28221|Deltaproteobacteria,2MRBG@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
SX3_k127_3839761_12	221027.JO40_03430	7.411e-149	488.0	COG0612@1|root,COG0612@2|Bacteria,2J5S5@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Peptidase M16 inactive domain	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
SX3_k127_3839761_25	221027.JO40_03435	7.463e-92	321.0	COG0612@1|root,COG0612@2|Bacteria,2J864@203691|Spirochaetes	203691|Spirochaetes	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
SX3_k127_3839761_44	234267.Acid_0266	5.719e-28	129.0	COG0454@1|root,COG0456@2|Bacteria,3Y5MX@57723|Acidobacteria	57723|Acidobacteria	K	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
SX3_k127_3839761_24	991905.SL003B_1558	5.208e-96	334.0	COG2313@1|root,COG2313@2|Bacteria,1MUQU@1224|Proteobacteria,2TUKT@28211|Alphaproteobacteria,4BQ78@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway	psuG	-	4.2.1.70	ko:K16329	ko00240,map00240	-	R01055	RC00432,RC00433	ko00000,ko00001,ko01000	-	-	-	Indigoidine_A
SX3_k127_3839761_58	742738.HMPREF9460_00753	2.311e-09	68.0	COG0524@1|root,COG1522@1|root,COG0524@2|Bacteria,COG1522@2|Bacteria,1TQR4@1239|Firmicutes,24AUP@186801|Clostridia,267XW@186813|unclassified Clostridiales	186801|Clostridia	GK	Winged helix-turn-helix DNA-binding	rbsK	-	2.7.1.15,2.7.1.83	ko:K00852,ko:K16328	ko00030,ko00240,map00030,map00240	-	R01051,R02750,R03315	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	HTH_24,PfkB
SX3_k127_3839761_23	1027273.GZ77_15170	3.483e-98	340.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1RPIW@1236|Gammaproteobacteria,1XPRY@135619|Oceanospirillales	135619|Oceanospirillales	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
SX3_k127_3839761_5	484018.BACPLE_02264	1.623e-193	616.0	COG1070@1|root,COG1070@2|Bacteria,4NFBZ@976|Bacteroidetes,2FPIS@200643|Bacteroidia,4AMYR@815|Bacteroidaceae	976|Bacteroidetes	G	Carbohydrate kinase, FGGY family protein	xylB_2	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
SX3_k127_3839761_45	1191523.MROS_0500	2.071e-25	108.0	COG1308@1|root,COG1308@2|Bacteria	2|Bacteria	K	protein transport	-	-	-	-	-	-	-	-	-	-	-	-	DUF4342
SX3_k127_3839761_57	911045.PSE_0703	4.533e-10	64.0	COG1396@1|root,COG1396@2|Bacteria,1RHIT@1224|Proteobacteria,2UFFJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	2TM,HTH_3
SX3_k127_3839761_60	1151122.AQYD01000007_gene1595	2.126e-07	62.0	COG3595@1|root,COG3595@2|Bacteria,2GKT3@201174|Actinobacteria,4FMVF@85023|Microbacteriaceae	201174|Actinobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
SX3_k127_3839761_28	180332.JTGN01000003_gene1951	7.422e-68	243.0	COG2017@1|root,COG2017@2|Bacteria,1TQVE@1239|Firmicutes,249E5@186801|Clostridia	186801|Clostridia	G	converts alpha-aldose to the beta-anomer	-	-	-	-	-	-	-	-	-	-	-	-	DUF5107
SX3_k127_3839761_4	1499967.BAYZ01000164_gene6663	7.442e-216	681.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_3839761_55	697281.Mahau_1536	2.382e-10	73.0	COG0407@1|root,COG0407@2|Bacteria,1UY51@1239|Firmicutes,24DZF@186801|Clostridia,42FW9@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_3839761_42	1195236.CTER_4146	1.199e-33	132.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,249FA@186801|Clostridia	186801|Clostridia	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057,ko:K10440	ko02010,map02010	M00212,M00221	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
SX3_k127_3889641_5	1123274.KB899415_gene2482	1.014e-19	89.0	COG1837@1|root,COG1837@2|Bacteria,2J92T@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the UPF0109 family	yhbY	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
SX3_k127_3889641_3	1123274.KB899415_gene2481	4.576e-28	117.0	COG0228@1|root,COG0228@2|Bacteria,2J8AD@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
SX3_k127_3889641_1	906968.Trebr_0890	9.91e-184	584.0	COG0541@1|root,COG0541@2|Bacteria,2J5MF@203691|Spirochaetes	203691|Spirochaetes	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
SX3_k127_3889641_7	545695.TREAZ_2691	2.052e-09	70.0	COG4105@1|root,COG4105@2|Bacteria	2|Bacteria	S	cell envelope organization	bamD	-	-	ko:K05807,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02000	1.B.33.1	GH23	-	YfiO
SX3_k127_3889641_0	1123274.KB899415_gene2477	4.341e-304	959.0	COG1196@1|root,COG1196@2|Bacteria,2J57J@203691|Spirochaetes	203691|Spirochaetes	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N
SX3_k127_3889641_2	580332.Slit_1637	3.799e-58	207.0	COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,2VQ06@28216|Betaproteobacteria,44VRD@713636|Nitrosomonadales	28216|Betaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
SX3_k127_3889641_6	1123274.KB899415_gene2475	3.222e-18	91.0	2DS3W@1|root,33EE8@2|Bacteria,2J8I7@203691|Spirochaetes	203691|Spirochaetes	S	SMART PUR-alpha beta gamma DNA RNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF3276
SX3_k127_3889641_4	349106.PsycPRwf_1159	1.354e-22	102.0	COG3228@1|root,COG3228@2|Bacteria,1RAHF@1224|Proteobacteria,1RZQU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the MtfA family	mtfA	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006508,GO:0006807,GO:0008134,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009889,GO:0010468,GO:0010556,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031326,GO:0043170,GO:0043433,GO:0044092,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0048519,GO:0050789,GO:0050794,GO:0051090,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0065009,GO:0070011,GO:0071704,GO:0080090,GO:0140096,GO:1901564,GO:1903506,GO:2000112,GO:2001141	-	ko:K09933	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_M90
SX3_k127_3939676_1	1122222.AXWR01000034_gene171	3.575e-100	334.0	COG4209@1|root,COG4209@2|Bacteria,1WK2U@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
SX3_k127_3939676_0	926569.ANT_08900	2.715e-141	473.0	COG0642@1|root,COG0784@1|root,COG1879@1|root,COG2207@1|root,COG0784@2|Bacteria,COG1879@2|Bacteria,COG2205@2|Bacteria,COG2207@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	4.2.3.1	ko:K01733,ko:K10439	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,ko02010,ko02030,map00260,map00750,map01100,map01110,map01120,map01230,map02010,map02030	M00018,M00212	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	HATPase_c,HTH_18,HisKA,Peripla_BP_3,Peripla_BP_4,Response_reg
SX3_k127_4007119_75	545695.TREAZ_0855	2.364e-09	64.0	2C8R1@1|root,2ZG03@2|Bacteria,2J6QN@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4007119_64	1045858.Bint_1355	3.815e-24	117.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	ko:K08642	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M23
SX3_k127_4007119_36	665571.STHERM_c08880	1.985e-82	287.0	COG2227@1|root,COG2227@2|Bacteria,2J6CB@203691|Spirochaetes	203691|Spirochaetes	H	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
SX3_k127_4007119_81	1304284.L21TH_2720	2.336e-05	54.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	rsbV	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
SX3_k127_4007119_72	744872.Spica_1690	8.668e-11	66.0	2AN0A@1|root,2ZDBY@2|Bacteria,2J9A6@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4007119_60	573413.Spirs_1428	1.378e-28	117.0	COG4517@1|root,COG4517@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF1820)	IV02_29925	-	-	-	-	-	-	-	-	-	-	-	DUF1820
SX3_k127_4007119_49	744872.Spica_1689	4.425e-54	193.0	COG2001@1|root,COG2001@2|Bacteria,2J7XS@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
SX3_k127_4007119_32	744872.Spica_1688	7.788e-96	323.0	COG0275@1|root,COG0275@2|Bacteria,2J6DH@203691|Spirochaetes	203691|Spirochaetes	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
SX3_k127_4007119_78	744872.Spica_1687	1.939e-07	60.0	2BPMB@1|root,32IEC@2|Bacteria,2J8ZG@203691|Spirochaetes	203691|Spirochaetes	D	Cell division protein, FtsL	-	-	-	-	-	-	-	-	-	-	-	-	DivIC,FtsL
SX3_k127_4007119_26	744872.Spica_1686	1.513e-108	368.0	COG0770@1|root,COG0770@2|Bacteria,2J5GH@203691|Spirochaetes	203691|Spirochaetes	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
SX3_k127_4007119_21	1121918.ARWE01000001_gene870	7.833e-124	408.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,42MCP@68525|delta/epsilon subdivisions,2WJDS@28221|Deltaproteobacteria,43S7M@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Phospho-N-acetylmuramoyl-pentapeptide-transferase signature 1	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	iAF987.Gmet_0409	Glycos_transf_4,MraY_sig1
SX3_k127_4007119_35	1123274.KB899413_gene868	1.273e-90	326.0	COG0772@1|root,COG0772@2|Bacteria,2J58T@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
SX3_k127_4007119_76	1121918.ARWE01000001_gene877	5.078e-09	66.0	COG1589@1|root,COG1589@2|Bacteria,1RDX7@1224|Proteobacteria,42VCZ@68525|delta/epsilon subdivisions,2WRVM@28221|Deltaproteobacteria,43SIM@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	POTRA domain, FtsQ-type	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
SX3_k127_4007119_17	1123274.KB899413_gene866	1.211e-165	529.0	COG0849@1|root,COG0849@2|Bacteria,2J5UK@203691|Spirochaetes	203691|Spirochaetes	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
SX3_k127_4007119_18	573413.Spirs_1552	1.83e-155	500.0	COG0206@1|root,COG0206@2|Bacteria,2J5EQ@203691|Spirochaetes	203691|Spirochaetes	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
SX3_k127_4007119_37	1123274.KB899413_gene864	5.573e-79	276.0	COG4974@1|root,COG4974@2|Bacteria,2J7GT@203691|Spirochaetes	203691|Spirochaetes	L	Belongs to the 'phage' integrase family	xerC	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
SX3_k127_4007119_57	754027.HMPREF9554_00203	3.078e-32	140.0	COG0457@1|root,COG0457@2|Bacteria,2J7BD@203691|Spirochaetes	203691|Spirochaetes	S	TPR domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_6,TPR_8
SX3_k127_4007119_46	744872.Spica_1678	1.864e-64	233.0	COG0758@1|root,COG0758@2|Bacteria,2J6UM@203691|Spirochaetes	203691|Spirochaetes	LU	DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
SX3_k127_4007119_2	906968.Trebr_0957	1.105e-296	936.0	COG0550@1|root,COG0550@2|Bacteria,2J5BS@203691|Spirochaetes	203691|Spirochaetes	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
SX3_k127_4007119_48	1356854.N007_03500	1.245e-59	219.0	COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,4HAEX@91061|Bacilli,277XE@186823|Alicyclobacillaceae	91061|Bacilli	D	Tyrosine recombinase XerD	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
SX3_k127_4007119_39	1480694.DC28_02300	7.396e-76	258.0	COG5405@1|root,COG5405@2|Bacteria,2J608@203691|Spirochaetes	203691|Spirochaetes	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
SX3_k127_4007119_11	573413.Spirs_1558	1.952e-187	597.0	COG1220@1|root,COG1220@2|Bacteria,2J68E@203691|Spirochaetes	203691|Spirochaetes	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
SX3_k127_4007119_51	1123274.KB899413_gene858	1.339e-46	171.0	COG1815@1|root,COG1815@2|Bacteria,2J804@203691|Spirochaetes	203691|Spirochaetes	N	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body	flgB	-	-	ko:K02387	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod
SX3_k127_4007119_44	665571.STHERM_c09080	1.995e-71	243.0	COG1558@1|root,COG1558@2|Bacteria,2J7Q7@203691|Spirochaetes	203691|Spirochaetes	N	Belongs to the flagella basal body rod proteins family	flgC	-	-	ko:K02388	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
SX3_k127_4007119_65	1123274.KB899413_gene856	8.836e-23	101.0	COG1677@1|root,COG1677@2|Bacteria,2J8B3@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook-basal body complex protein	fliE	-	-	ko:K02408	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliE
SX3_k127_4007119_7	1123274.KB899413_gene855	1.339e-210	668.0	COG1766@1|root,COG1766@2|Bacteria,2J5KB@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar M-ring protein	fliF	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
SX3_k127_4007119_13	1480694.DC28_02330	1.598e-181	573.0	COG1536@1|root,COG1536@2|Bacteria,2J5CI@203691|Spirochaetes	203691|Spirochaetes	N	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliG	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
SX3_k127_4007119_33	573413.Spirs_1564	1.059e-94	319.0	COG1317@1|root,COG1317@2|Bacteria,2J5KZ@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar assembly protein FliH	fliH	-	-	ko:K02411	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliH
SX3_k127_4007119_9	744872.Spica_1667	1.484e-192	610.0	COG1157@1|root,COG1157@2|Bacteria,2J5IJ@203691|Spirochaetes	203691|Spirochaetes	NU	Flagellar protein export ATPase FliI	fliI	-	3.6.3.14	ko:K02412	ko02040,map02040	-	-	-	ko00000,ko00001,ko01000,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	ATP-synt_ab,ATP-synt_ab_N
SX3_k127_4007119_74	1123274.KB899413_gene851	4.355e-10	67.0	COG2882@1|root,COG2882@2|Bacteria	2|Bacteria	N	bacterial-type flagellum organization	fliJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02413	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliJ
SX3_k127_4007119_50	744872.Spica_1540	1.678e-52	192.0	COG3334@1|root,COG3334@2|Bacteria,2J66F@203691|Spirochaetes	203691|Spirochaetes	S	PFAM MgtE intracellular	flbB	-	-	ko:K02383	-	-	-	-	ko00000,ko02035	-	-	-	-
SX3_k127_4007119_70	1123274.KB899413_gene849	1.139e-16	92.0	COG3144@1|root,COG3144@2|Bacteria,2J8AU@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook-length control protein	-	-	-	ko:K02414	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_hook
SX3_k127_4007119_55	744872.Spica_1538	1.511e-43	163.0	COG1843@1|root,COG1843@2|Bacteria,2J806@203691|Spirochaetes	203691|Spirochaetes	N	flagellar hook	flgD	-	-	ko:K02389	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgD
SX3_k127_4007119_6	665571.STHERM_c09180	9.077e-215	674.0	COG1749@1|root,COG1749@2|Bacteria,2J5H4@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook protein flgE	flgE	-	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlaE,Flg_bb_rod,Flg_bbr_C
SX3_k127_4007119_59	889378.Spiaf_2096	6.595e-29	116.0	COG1582@1|root,COG1582@2|Bacteria,2J8UC@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar protein FlbD	flbD	-	-	ko:K02385	-	-	-	-	ko00000,ko02035	-	-	-	FlbD
SX3_k127_4007119_34	665571.STHERM_c09200	7.909e-92	308.0	COG1291@1|root,COG1291@2|Bacteria,2J5HT@203691|Spirochaetes	203691|Spirochaetes	N	MotA TolQ ExbB proton channel family	motA	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
SX3_k127_4007119_27	665571.STHERM_c09210	8.043e-103	339.0	COG1360@1|root,COG1360@2|Bacteria,2J68Q@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar motor protein	motB	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
SX3_k127_4007119_58	1321815.HMPREF9193_01372	1.295e-29	124.0	COG1580@1|root,COG1580@2|Bacteria,2J7MX@203691|Spirochaetes	203691|Spirochaetes	N	Controls the rotational direction of flagella during chemotaxis	fliL	-	-	ko:K02415	-	-	-	-	ko00000,ko02035	-	-	-	FliL
SX3_k127_4007119_15	573413.Spirs_1575	1.058e-170	541.0	COG1868@1|root,COG1868@2|Bacteria,2J5WR@203691|Spirochaetes	203691|Spirochaetes	N	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliM	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
SX3_k127_4007119_31	1123274.KB899413_gene841	4.541e-100	339.0	COG1776@1|root,COG1886@1|root,COG1776@2|Bacteria,COG1886@2|Bacteria,2J5P8@203691|Spirochaetes	203691|Spirochaetes	N	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliN	-	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FliMN_C
SX3_k127_4007119_67	1123274.KB899413_gene840	1.923e-22	105.0	COG3190@1|root,COG3190@2|Bacteria	2|Bacteria	N	flagellar	fliZ	-	-	ko:K02418	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliO
SX3_k127_4007119_30	744872.Spica_1529	2.802e-100	334.0	COG1338@1|root,COG1338@2|Bacteria,2J5S9@203691|Spirochaetes	203691|Spirochaetes	N	Plays a role in the flagellum-specific transport system	fliP	-	-	ko:K02419	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliP
SX3_k127_4007119_77	573413.Spirs_1579	1.525e-08	57.0	COG1987@1|root,COG1987@2|Bacteria,2J93G@203691|Spirochaetes	203691|Spirochaetes	N	Role in flagellar biosynthesis	fliQ	-	-	ko:K02420	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_3
SX3_k127_4007119_80	243365.CV_3125	6.093e-06	48.0	COG1987@1|root,COG1987@2|Bacteria,1N73W@1224|Proteobacteria,2VU8S@28216|Betaproteobacteria,2KRKH@206351|Neisseriales	206351|Neisseriales	N	Role in flagellar biosynthesis	fliQ1	-	-	ko:K02420	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_3
SX3_k127_4007119_45	573413.Spirs_1580	5.008e-71	253.0	COG1684@1|root,COG1684@2|Bacteria,2J6DD@203691|Spirochaetes	203691|Spirochaetes	N	Role in flagellar biosynthesis	fliR	-	-	ko:K02421	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1
SX3_k127_4007119_22	665571.STHERM_c09290	2.076e-123	421.0	COG1377@1|root,COG1377@2|Bacteria,2J5EU@203691|Spirochaetes	203691|Spirochaetes	N	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhB	-	-	ko:K02401	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_2
SX3_k127_4007119_3	665571.STHERM_c09300	8.383e-294	916.0	COG1298@1|root,COG1298@2|Bacteria,2J57F@203691|Spirochaetes	203691|Spirochaetes	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
SX3_k127_4007119_23	1123274.KB899413_gene834	4.944e-119	394.0	COG1419@1|root,COG1419@2|Bacteria,2J5TV@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar biosynthesis protein FlhF	flhF	-	-	ko:K02404	-	-	-	-	ko00000,ko02035	-	-	-	SRP54
SX3_k127_4007119_20	1480694.DC28_02435	8.319e-126	408.0	COG0455@1|root,COG0455@2|Bacteria,2J5B7@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the ParA family	fleN	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	AAA_31,CbiA,ParA
SX3_k127_4007119_19	1123274.KB899413_gene831	1.738e-127	411.0	COG1191@1|root,COG1191@2|Bacteria,2J5RA@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the sigma-70 factor family	fliA	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
SX3_k127_4007119_10	744872.Spica_1520	7.86e-190	615.0	COG1315@1|root,COG1315@2|Bacteria,2J5S8@203691|Spirochaetes	203691|Spirochaetes	L	COGs COG1315 polymerase most protein contain PALM domain HD hydrolase domain and Zn-ribbon domain	-	-	-	ko:K09749	-	-	-	-	ko00000	-	-	-	FapA,Jag_N
SX3_k127_4007119_71	665571.STHERM_c09360	1.088e-13	74.0	29A3I@1|root,31CTV@2|Bacteria,2J8T8@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4007119_69	573413.Spirs_1589	2.417e-17	88.0	28TF5@1|root,2ZFP6@2|Bacteria,2J8Y7@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4007119_73	1408422.JHYF01000002_gene2427	1.229e-10	67.0	COG0443@1|root,COG0443@2|Bacteria,1TP1J@1239|Firmicutes,248QV@186801|Clostridia,36DJ7@31979|Clostridiaceae	186801|Clostridia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
SX3_k127_4007119_61	913865.DOT_5366	1.623e-28	121.0	COG0835@1|root,COG0835@2|Bacteria,1V4HH@1239|Firmicutes,24JV4@186801|Clostridia,261WX@186807|Peptococcaceae	186801|Clostridia	NT	Chemotaxis signal transduction protein	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
SX3_k127_4007119_28	646529.Desaci_3832	1.048e-101	356.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1TPMS@1239|Firmicutes,24858@186801|Clostridia,2603B@186807|Peptococcaceae	186801|Clostridia	NT	Signal transducing histidine kinase homodimeric	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
SX3_k127_4007119_54	335541.Swol_0863	1.393e-44	165.0	COG2204@1|root,COG2204@2|Bacteria,1UHXE@1239|Firmicutes,25E6A@186801|Clostridia,42JXC@68298|Syntrophomonadaceae	186801|Clostridia	T	cheY-homologous receiver domain	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
SX3_k127_4007119_29	573413.Spirs_2629	1.816e-100	360.0	COG2604@1|root,COG2604@2|Bacteria,2J5P0@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF115	-	-	-	-	-	-	-	-	-	-	-	-	MAF_flag10
SX3_k127_4007119_16	1123274.KB899435_gene1312	4.693e-170	555.0	COG0768@1|root,COG0768@2|Bacteria,2J5D8@203691|Spirochaetes	203691|Spirochaetes	M	Cell division protein ftsI	pbp3	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
SX3_k127_4007119_43	665571.STHERM_c07460	9.01e-74	265.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,2J6RF@203691|Spirochaetes	203691|Spirochaetes	M	LysM domain M23 M37 peptidase domain protein	nlpD	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23
SX3_k127_4007119_52	221027.JO40_05950	3.297e-46	179.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,2J6RF@203691|Spirochaetes	203691|Spirochaetes	M	LysM domain M23 M37 peptidase domain protein	nlpD	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23
SX3_k127_4007119_1	1123274.KB899435_gene1309	0.0	1181.0	COG0653@1|root,COG0653@2|Bacteria,2J5UR@203691|Spirochaetes	203691|Spirochaetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
SX3_k127_4007119_41	545694.TREPR_2351	3.508e-75	268.0	2CK99@1|root,3464J@2|Bacteria,2J60S@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4007119_42	1123274.KB899435_gene1307	4.449e-75	271.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2J5T7@203691|Spirochaetes	203691|Spirochaetes	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
SX3_k127_4007119_79	744872.Spica_1439	3.984e-07	57.0	2FC9X@1|root,2ZJPR@2|Bacteria,2J8DF@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4007119_14	1123288.SOV_4c06990	1.278e-173	567.0	COG0480@1|root,COG0480@2|Bacteria,1TPWN@1239|Firmicutes,4H1Y3@909932|Negativicutes	909932|Negativicutes	J	elongation factor G	fusA_1	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
SX3_k127_4007119_4	744872.Spica_0853	2.693e-278	877.0	COG0480@1|root,COG0480@2|Bacteria,2J5D3@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
SX3_k127_4007119_82	412597.AEPN01000031_gene496	0.0005335	50.0	COG2340@1|root,COG2340@2|Bacteria,1MZ84@1224|Proteobacteria,2V4FW@28211|Alphaproteobacteria,2PWWS@265|Paracoccus	28211|Alphaproteobacteria	S	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP
SX3_k127_4007119_5	1123274.KB899415_gene2416	1.073e-223	720.0	COG0018@1|root,COG0018@2|Bacteria,2J5EP@203691|Spirochaetes	203691|Spirochaetes	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
SX3_k127_4007119_0	665571.STHERM_c15920	0.0	1516.0	COG0060@1|root,COG0060@2|Bacteria,2J57V@203691|Spirochaetes	203691|Spirochaetes	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
SX3_k127_4007119_47	1123274.KB899415_gene2505	3.421e-64	227.0	COG0118@1|root,COG0118@2|Bacteria,2J8MS@203691|Spirochaetes	203691|Spirochaetes	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
SX3_k127_4007119_25	665571.STHERM_c15890	1.104e-111	374.0	COG0107@1|root,COG0107@2|Bacteria,2J6FB@203691|Spirochaetes	203691|Spirochaetes	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
SX3_k127_4007119_66	573413.Spirs_1898	1.225e-22	106.0	COG2331@1|root,COG2331@2|Bacteria,2J904@203691|Spirochaetes	203691|Spirochaetes	S	FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
SX3_k127_4007119_24	573413.Spirs_1899	4.957e-117	389.0	COG0301@1|root,COG0301@2|Bacteria,2J64Z@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
SX3_k127_4007119_38	1539298.JO41_11820	1.842e-76	273.0	COG1104@1|root,COG1104@2|Bacteria,2J5VR@203691|Spirochaetes	203691|Spirochaetes	E	Cysteine desulfurase	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
SX3_k127_4007119_62	1123274.KB899415_gene2510	9.612e-28	115.0	COG0640@1|root,COG0640@2|Bacteria,2J8H9@203691|Spirochaetes	203691|Spirochaetes	K	arsR family	-	-	-	ko:K22298	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
SX3_k127_4007119_40	665571.STHERM_c15850	1.66e-75	273.0	COG1596@1|root,COG1596@2|Bacteria,2J6A1@203691|Spirochaetes	203691|Spirochaetes	M	export protein	-	-	-	-	-	-	-	-	-	-	-	-	SLBB
SX3_k127_4007119_63	633148.Tagg_0331	2.279e-26	113.0	COG0375@1|root,arCOG04426@2157|Archaea,2XQQ3@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM hydrogenase expression synthesis HypA	-	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
SX3_k127_4007119_53	593117.TGAM_0234	6.758e-45	180.0	COG0489@1|root,arCOG00585@2157|Archaea,2Y2C0@28890|Euryarchaeota,24314@183968|Thermococci	183968|Thermococci	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	ParA
SX3_k127_4007119_68	1288963.ADIS_4606	1.008e-18	100.0	COG2407@1|root,COG2407@2|Bacteria,4NF0C@976|Bacteroidetes,47JET@768503|Cytophagia	976|Bacteroidetes	G	Catalyzes the conversion of L-arabinose to L-ribulose	-	-	5.3.1.4	ko:K01804	ko00040,ko01100,map00040,map01100	-	R01761	RC00516	ko00000,ko00001,ko01000	-	-	-	Arabinose_Isome,Fucose_iso_C
SX3_k127_4007119_12	1499967.BAYZ01000143_gene6122	8.352e-185	584.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX3_k127_4007119_8	1499967.BAYZ01000143_gene6121	3.326e-193	609.0	COG0399@1|root,COG0399@2|Bacteria,2NQH7@2323|unclassified Bacteria	2|Bacteria	E	Cys/Met metabolism PLP-dependent enzyme	stsA	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0016051,GO:0043170,GO:0044238,GO:0071704,GO:1901576	2.6.1.109	ko:K19715	-	-	R11395	RC00160	ko00000,ko01000,ko01005	-	-	-	DegT_DnrJ_EryC1
SX3_k127_4007119_56	1450694.BTS2_2658	1.644e-42	171.0	COG1940@1|root,COG1940@2|Bacteria,1TQCE@1239|Firmicutes,4HDE3@91061|Bacilli,1ZC4Y@1386|Bacillus	91061|Bacilli	GK	ROK family	xylR	-	-	-	-	-	-	-	-	-	-	-	HTH_24,MarR_2,ROK
SX3_k127_415500_1	1487923.DP73_12970	2.618e-59	220.0	COG1410@1|root,COG1410@2|Bacteria,1V5ZS@1239|Firmicutes,24I4A@186801|Clostridia	186801|Clostridia	E	PFAM Vitamin B12 dependent methionine synthase, activation domain	-	-	-	-	-	-	-	-	-	-	-	-	Met_synt_B12
SX3_k127_415500_0	518766.Rmar_0136	4.8e-115	381.0	COG1509@1|root,COG1509@2|Bacteria,4NJ79@976|Bacteroidetes,1FJ3Z@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Lysine-2,3-aminomutase	ablA	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,LAM_C,Radical_SAM
SX3_k127_4177655_14	1499967.BAYZ01000019_gene6334	3.336e-14	81.0	COG4134@1|root,COG4134@2|Bacteria	2|Bacteria	S	Bacterial extracellular solute-binding protein	-	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_8
SX3_k127_4177655_5	913325.N799_14280	2.178e-79	273.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,1RNVM@1236|Gammaproteobacteria,1X33N@135614|Xanthomonadales	135614|Xanthomonadales	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
SX3_k127_4177655_2	1379698.RBG1_1C00001G1253	9.643e-108	371.0	COG1022@1|root,COG1022@2|Bacteria,2NNTM@2323|unclassified Bacteria	2|Bacteria	I	COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming)	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
SX3_k127_4177655_13	1449351.RISW2_02835	7.856e-17	91.0	COG0637@1|root,COG0637@2|Bacteria,1PUMZ@1224|Proteobacteria,2U52Q@28211|Alphaproteobacteria,4KMJU@93682|Roseivivax	28211|Alphaproteobacteria	S	haloacid dehalogenase-like hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
SX3_k127_4177655_7	1128421.JAGA01000002_gene964	6.481e-65	233.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
SX3_k127_4177655_15	545694.TREPR_0693	7.629e-14	81.0	2BRMP@1|root,32KM3@2|Bacteria,2J6W4@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Late competence development protein ComFB	-	-	-	ko:K02241	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	ComFB
SX3_k127_4177655_8	1307761.L21SP2_2372	2.91e-53	208.0	COG1639@1|root,COG1639@2|Bacteria	2|Bacteria	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
SX3_k127_4177655_20	1415756.JQMY01000001_gene550	0.0006159	54.0	COG0457@1|root,COG0457@2|Bacteria,1MXMD@1224|Proteobacteria,2U0F2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
SX3_k127_4177655_17	1303518.CCALI_02135	3.775e-08	66.0	COG2199@1|root,COG2203@1|root,COG3437@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,COG3437@2|Bacteria	2|Bacteria	T	response regulator, receiver	yeaP	GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0052621	2.7.7.65	ko:K13069,ko:K18967	-	-	R08057	-	ko00000,ko01000,ko02000	9.B.34.1.1	-	-	GAF,GAF_2,GAF_3,GGDEF,HD,HD_5
SX3_k127_4177655_3	1121451.DESAM_21835	4.752e-93	326.0	COG0438@1|root,COG0438@2|Bacteria,1MVEG@1224|Proteobacteria,42Q1K@68525|delta/epsilon subdivisions,2WJ1U@28221|Deltaproteobacteria,2M8XU@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Domain of unknown function (DUF3492)	-	-	-	ko:K21011	ko02025,map02025	-	-	-	ko00000,ko00001,ko01003	-	GT4	-	DUF3492,Glycos_transf_1
SX3_k127_4177655_10	526222.Desal_2683	6.624e-37	157.0	COG4267@1|root,COG4267@2|Bacteria,1MUQN@1224|Proteobacteria,42Q3G@68525|delta/epsilon subdivisions,2WKR6@28221|Deltaproteobacteria,2MAM4@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Putative exopolysaccharide Exporter (EPS-E)	-	-	-	ko:K21012	ko02025,map02025	-	-	-	ko00000,ko00001	-	-	-	PelG
SX3_k127_4177655_16	1499967.BAYZ01000185_gene4530	1.312e-08	58.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	2.7.13.3	ko:K20974	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1
SX3_k127_4177655_18	1123504.JQKD01000053_gene4337	2.509e-05	54.0	COG2199@1|root,COG2199@2|Bacteria,1MUV8@1224|Proteobacteria,2VI6E@28216|Betaproteobacteria,4ABJF@80864|Comamonadaceae	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_8,PAS_9
SX3_k127_4177655_9	744872.Spica_2768	7.832e-52	194.0	COG0744@1|root,COG0744@2|Bacteria	2|Bacteria	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129,3.4.16.4	ko:K03814,ko:K05365,ko:K05366,ko:K21464	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
SX3_k127_4177655_4	941824.TCEL_01715	8.264e-88	301.0	COG0144@1|root,COG0144@2|Bacteria,1TPGQ@1239|Firmicutes,247N0@186801|Clostridia,36F0B@31979|Clostridiaceae	186801|Clostridia	J	NOL1 NOP2 sun family	rsmF	-	-	-	-	-	-	-	-	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,Methyltranf_PUA,RsmF_methylt_CI
SX3_k127_4177655_12	1123274.KB899407_gene258	1.149e-17	92.0	29IC7@1|root,3059E@2|Bacteria,2JAQH@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4177655_1	909663.KI867149_gene3381	5.676e-121	404.0	COG0116@1|root,COG0116@2|Bacteria,1MUQM@1224|Proteobacteria,42NJ1@68525|delta/epsilon subdivisions,2WJ5S@28221|Deltaproteobacteria,2MQHY@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Putative RNA methylase family UPF0020	rlmL	-	2.1.1.173,2.1.1.264	ko:K07444,ko:K12297	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,THUMP,UPF0020
SX3_k127_4177655_11	867845.KI911784_gene2572	8.226e-24	115.0	COG1196@1|root,COG1196@2|Bacteria,2G788@200795|Chloroflexi,376Y7@32061|Chloroflexia	32061|Chloroflexia	D	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
SX3_k127_4177655_6	886293.Sinac_6422	1.855e-75	273.0	COG0421@1|root,COG4262@1|root,COG0421@2|Bacteria,COG4262@2|Bacteria,2IYZX@203682|Planctomycetes	203682|Planctomycetes	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
SX3_k127_4177655_0	744872.Spica_2714	0.0	1080.0	COG0495@1|root,COG0495@2|Bacteria,2J5BV@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
SX3_k127_4243262_1	1232453.BAIF02000004_gene1563	3.646e-51	195.0	COG1172@1|root,COG1172@2|Bacteria,1UVWS@1239|Firmicutes,24Y3D@186801|Clostridia	186801|Clostridia	G	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
SX3_k127_4243262_0	556261.HMPREF0240_04485	2.579e-72	259.0	COG1879@1|root,COG1879@2|Bacteria,1US0E@1239|Firmicutes,24Y71@186801|Clostridia	186801|Clostridia	G	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_4
SX3_k127_4243262_2	1499967.BAYZ01000111_gene2953	3.697e-34	134.0	COG3254@1|root,COG3254@2|Bacteria,2NRFN@2323|unclassified Bacteria	2|Bacteria	S	L-rhamnose mutarotase	-	-	5.1.3.32	ko:K03534	-	-	R10819	RC00563	ko00000,ko01000	-	-	-	rhaM
SX3_k127_4244372_7	1499967.BAYZ01000159_gene538	4.312e-67	241.0	COG0407@1|root,COG0407@2|Bacteria,2NRD5@2323|unclassified Bacteria	2|Bacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
SX3_k127_4244372_1	309799.DICTH_1588	7.634e-155	499.0	COG4952@1|root,COG4952@2|Bacteria	2|Bacteria	M	isomerase activity	xylA_2	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
SX3_k127_4244372_8	5722.XP_001302338.1	6.357e-66	246.0	COG0554@1|root,KOG2517@2759|Eukaryota	2759|Eukaryota	C	glycerol kinase activity	SHPK	GO:0002237,GO:0002682,GO:0002694,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009605,GO:0009607,GO:0009617,GO:0009987,GO:0010033,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0031347,GO:0032101,GO:0032496,GO:0033993,GO:0034097,GO:0034641,GO:0035962,GO:0035963,GO:0042221,GO:0043030,GO:0043207,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048583,GO:0050277,GO:0050727,GO:0050789,GO:0050794,GO:0050865,GO:0050896,GO:0051156,GO:0051186,GO:0051704,GO:0051707,GO:0051716,GO:0055086,GO:0065007,GO:0070670,GO:0070887,GO:0071216,GO:0071219,GO:0071222,GO:0071310,GO:0071345,GO:0071353,GO:0071396,GO:0071704,GO:0072524,GO:0080134,GO:1901135,GO:1901360,GO:1901564,GO:1901700,GO:1901701	2.7.1.14	ko:K11214	ko00710,map00710	-	R01844	RC00002,RC00608	ko00000,ko00001,ko01000	-	-	-	FGGY_N
SX3_k127_4244372_16	765698.Mesci_5314	6.133e-17	94.0	COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,2TSJV@28211|Alphaproteobacteria,43HIF@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Belongs to the RuBisCO large chain family	rbcL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
SX3_k127_4244372_9	1304880.JAGB01000002_gene1921	2.005e-59	219.0	COG1482@1|root,COG1482@2|Bacteria,1V0PH@1239|Firmicutes,2487K@186801|Clostridia	186801|Clostridia	G	mannose-6-phosphate isomerase, class I	manA	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS19425	PMI_typeI
SX3_k127_4244372_13	465817.ETA_34190	4.516e-48	187.0	COG0246@1|root,COG0246@2|Bacteria,1MXV8@1224|Proteobacteria,1RPCP@1236|Gammaproteobacteria,3X4S6@551|Erwinia	1236|Gammaproteobacteria	C	Mannitol-1-phosphate 5-dehydrogenase	mtlD	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006059,GO:0006066,GO:0008150,GO:0008152,GO:0008926,GO:0009056,GO:0009987,GO:0016052,GO:0016491,GO:0016614,GO:0016616,GO:0019400,GO:0019405,GO:0019407,GO:0019592,GO:0019594,GO:0019751,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046164,GO:0046174,GO:0055114,GO:0071704,GO:1901575,GO:1901615,GO:1901616	1.1.1.17	ko:K00009	ko00051,map00051	-	R02703	RC00085	ko00000,ko00001,ko01000	-	-	iSBO_1134.SBO_3598,iSbBS512_1146.SbBS512_E4017	Mannitol_dh,Mannitol_dh_C
SX3_k127_4244372_12	1173025.GEI7407_3197	2.612e-48	190.0	COG2199@1|root,COG3706@2|Bacteria,1G3FB@1117|Cyanobacteria,1H736@1150|Oscillatoriales	1117|Cyanobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HisKA_7TM,PAS_4,PAS_8
SX3_k127_4244372_19	166318.Syn8016DRAFT_0721	1.615e-05	57.0	COG2203@1|root,COG2203@2|Bacteria,1G3XH@1117|Cyanobacteria,1H3W6@1129|Synechococcus	1117|Cyanobacteria	T	COG2203 FOG GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,Guanylate_cyc,HATPase_c,HisKA,PAS,PAS_4,Response_reg
SX3_k127_4244372_0	1123274.KB899412_gene1424	1.186e-179	580.0	COG1486@1|root,COG1486@2|Bacteria,2J688@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Glycoside hydrolase, family 4	-	-	3.2.1.22	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
SX3_k127_4244372_3	926550.CLDAP_24220	4.266e-135	454.0	28JDC@1|root,2Z97R@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4432)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4432
SX3_k127_4244372_2	1220535.IMCC14465_06300	2.101e-136	451.0	COG1384@1|root,COG1384@2|Bacteria,1MV32@1224|Proteobacteria,2TQYH@28211|Alphaproteobacteria,4BPG2@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
SX3_k127_4244372_17	1291050.JAGE01000001_gene1979	3.996e-14	85.0	2DN2J@1|root,32V6S@2|Bacteria,1V1QE@1239|Firmicutes,25HR2@186801|Clostridia,3WKKB@541000|Ruminococcaceae	186801|Clostridia	S	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
SX3_k127_4244372_11	536227.CcarbDRAFT_2896	5.38e-52	208.0	COG3225@1|root,COG3225@2|Bacteria,1TT1J@1239|Firmicutes,24BC2@186801|Clostridia,36HT6@31979|Clostridiaceae	186801|Clostridia	N	ABC-type uncharacterized transport system	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3,ABC_transp_aux
SX3_k127_4244372_15	697281.Mahau_2216	6.297e-41	173.0	COG1277@1|root,COG1277@2|Bacteria,1UZXS@1239|Firmicutes,248ME@186801|Clostridia,42FRK@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_2,ABC2_membrane_3,ABC2_membrane_5
SX3_k127_4244372_5	1121335.Clst_0896	1.135e-93	317.0	COG1131@1|root,COG1131@2|Bacteria,1TQUS@1239|Firmicutes,25AZ1@186801|Clostridia,3WH5S@541000|Ruminococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_4244372_4	1120973.AQXL01000107_gene1990	1.422e-123	403.0	COG0656@1|root,COG0656@2|Bacteria,1TPM1@1239|Firmicutes,4HARE@91061|Bacilli,278WP@186823|Alicyclobacillaceae	91061|Bacilli	S	Aldo/keto reductase family	yvgN	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SX3_k127_4244372_14	595460.RRSWK_05035	1.781e-41	167.0	COG3622@1|root,COG3622@2|Bacteria,2J06A@203682|Planctomycetes	203682|Planctomycetes	G	Xylose isomerase-like TIM barrel	-	-	5.3.1.22	ko:K01816	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
SX3_k127_4244372_6	33035.JPJF01000027_gene2740	1.434e-73	258.0	COG1082@1|root,COG1082@2|Bacteria,1UYHR@1239|Firmicutes,25C7S@186801|Clostridia,3Y2EH@572511|Blautia	186801|Clostridia	G	Xylose isomerase-like TIM barrel	-	GO:0003674,GO:0003824,GO:0005488,GO:0016853,GO:0016854,GO:0016857,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0050897	5.1.3.30,5.1.3.31	ko:K18910	-	-	R10817,R10818	RC03111,RC03283	ko00000,ko01000	-	-	-	AP_endonuc_2
SX3_k127_4244372_10	398511.BpOF4_01175	2.938e-54	204.0	COG1737@1|root,COG1737@2|Bacteria,1TR0N@1239|Firmicutes,4HB9E@91061|Bacilli,1ZCCD@1386|Bacillus	91061|Bacilli	K	RpiR family transcriptional regulator	gntR	-	-	-	-	-	-	-	-	-	-	-	HTH_6,SIS
SX3_k127_4244372_18	556261.HMPREF0240_03742	2.908e-12	73.0	COG1879@1|root,COG1879@2|Bacteria,1VAVT@1239|Firmicutes,24QH9@186801|Clostridia	186801|Clostridia	G	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_4
SX3_k127_4256154_0	519989.ECTPHS_14004	1.859e-179	572.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1WVZP@135613|Chromatiales	135613|Chromatiales	L	reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
SX3_k127_4256154_2	1121033.AUCF01000004_gene5005	3.098e-55	203.0	COG2267@1|root,COG2267@2|Bacteria,1NYNM@1224|Proteobacteria,2TWBS@28211|Alphaproteobacteria,2JZ0S@204441|Rhodospirillales	204441|Rhodospirillales	I	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
SX3_k127_4256154_1	1116472.MGMO_21c00240	6.066e-169	536.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,1XEIR@135618|Methylococcales	135618|Methylococcales	H	Belongs to the citrate synthase family	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
SX3_k127_4317159_14	1480694.DC28_06800	2.127e-56	199.0	COG1136@1|root,COG1136@2|Bacteria,2J5PI@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_4317159_2	1480694.DC28_06805	1.573e-113	383.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,2J5MA@203691|Spirochaetes	203691|Spirochaetes	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
SX3_k127_4317159_5	1307761.L21SP2_0315	7.842e-89	309.0	COG4591@1|root,COG4591@2|Bacteria,2J6KF@203691|Spirochaetes	203691|Spirochaetes	M	ABC transporter permease	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX3_k127_4317159_12	1480694.DC28_06815	1.909e-76	263.0	COG2834@1|root,COG2834@2|Bacteria,2J5TZ@203691|Spirochaetes	203691|Spirochaetes	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
SX3_k127_4317159_16	158190.SpiGrapes_2919	5.456e-48	188.0	2DNEA@1|root,32X2Y@2|Bacteria,2J767@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4317159_23	877418.ATWV01000011_gene32	2.712e-05	53.0	2DNEA@1|root,32X2Y@2|Bacteria,2J767@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4317159_7	479432.Sros_0274	9.339e-85	289.0	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria,4EHWZ@85012|Streptosporangiales	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_4317159_15	588581.Cpap_1155	4.139e-53	196.0	COG0842@1|root,COG0842@2|Bacteria,1TPZY@1239|Firmicutes,24CZM@186801|Clostridia,3WS3K@541000|Ruminococcaceae	186801|Clostridia	V	ABC-2 type transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane
SX3_k127_4317159_13	479434.Sthe_1551	1.727e-74	266.0	COG4585@1|root,COG4585@2|Bacteria,2G7ZR@200795|Chloroflexi,27YV8@189775|Thermomicrobia	189775|Thermomicrobia	T	Histidine kinase	-	-	2.7.13.3	ko:K07675	ko02020,map02020	M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA_3
SX3_k127_4317159_9	1122221.JHVI01000002_gene797	5.942e-82	280.0	COG2197@1|root,COG2197@2|Bacteria,1WMGV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
SX3_k127_4317159_24	1345023.M467_05270	0.0008503	49.0	COG0604@1|root,COG0604@2|Bacteria,1TSWF@1239|Firmicutes,4HANV@91061|Bacilli	91061|Bacilli	C	NADPH quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
SX3_k127_4317159_22	886293.Sinac_0140	4.362e-06	57.0	2EGZK@1|root,33ARQ@2|Bacteria,2J4A7@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4317159_19	391624.OIHEL45_17016	1.045e-16	81.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3335 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_29,HTH_32
SX3_k127_4317159_18	1214101.BN159_0048	1.228e-20	99.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2GJQI@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_32
SX3_k127_4317159_10	1122223.KB890699_gene661	3.929e-79	275.0	COG0411@1|root,COG0411@2|Bacteria,1WJG8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
SX3_k127_4317159_8	926550.CLDAP_28080	5.581e-82	280.0	COG0410@1|root,COG0410@2|Bacteria,2G69M@200795|Chloroflexi	200795|Chloroflexi	E	PFAM ABC transporter related	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
SX3_k127_4317159_6	604331.AUHY01000113_gene2328	1.367e-87	302.0	COG0559@1|root,COG0559@2|Bacteria,1WJ0D@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
SX3_k127_4317159_4	765698.Mesci_0558	1.029e-93	332.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2U2WW@28211|Alphaproteobacteria,43QW4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
SX3_k127_4317159_1	526227.Mesil_3294	3.242e-130	444.0	COG0683@1|root,COG0683@2|Bacteria,1WKAP@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
SX3_k127_4317159_11	1265505.ATUG01000001_gene3432	2.632e-78	278.0	COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,42QNA@68525|delta/epsilon subdivisions	1224|Proteobacteria	F	PFAM Creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
SX3_k127_4317159_0	1480694.DC28_12175	7.465e-154	503.0	COG0534@1|root,COG0534@2|Bacteria	2|Bacteria	V	drug transmembrane transporter activity	norM-2	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
SX3_k127_4317159_17	1121904.ARBP01000003_gene6217	1.679e-31	138.0	COG1725@1|root,COG1725@2|Bacteria,4NT1X@976|Bacteroidetes,47QCP@768503|Cytophagia	976|Bacteroidetes	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	GntR
SX3_k127_4317159_21	1237149.C900_02010	3.165e-11	74.0	2DPSV@1|root,3338R@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4317159_3	1121904.ARBP01000003_gene6219	2.528e-96	323.0	COG1131@1|root,COG1131@2|Bacteria,4NFRV@976|Bacteroidetes,47N9E@768503|Cytophagia	976|Bacteroidetes	V	ABC-type multidrug transport system ATPase component	cbiO	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_4317159_20	36033.XP_001643963.1	1.062e-15	82.0	COG0664@1|root,KOG2968@2759|Eukaryota,38ERP@33154|Opisthokonta,3NU33@4751|Fungi,3QJX8@4890|Ascomycota,3RTNX@4891|Saccharomycetes,3S099@4893|Saccharomycetaceae	4751|Fungi	I	Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis	NTE1	GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009395,GO:0009405,GO:0009889,GO:0009987,GO:0012505,GO:0016020,GO:0016021,GO:0016042,GO:0016298,GO:0016787,GO:0016788,GO:0019216,GO:0019220,GO:0019222,GO:0019637,GO:0031224,GO:0031323,GO:0031326,GO:0031984,GO:0034638,GO:0042175,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044419,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0046434,GO:0046470,GO:0046475,GO:0046486,GO:0046503,GO:0046890,GO:0050789,GO:0050794,GO:0051174,GO:0051704,GO:0052689,GO:0065007,GO:0071071,GO:0071704,GO:0080090,GO:0097164,GO:0098827,GO:1901564,GO:1901565,GO:1901575,GO:1903725	3.1.1.5,3.1.3.99	ko:K14676,ko:K18550	ko00230,ko00564,ko00760,ko01100,map00230,map00564,map00760,map01100	-	R01126,R02323,R02746,R02747,R03346,R03416,R03417	RC00017,RC00020,RC00037,RC00041,RC00094	ko00000,ko00001,ko01000	-	-	-	Patatin,cNMP_binding
SX3_k127_4317192_1	573413.Spirs_2041	1.726e-275	867.0	COG0782@1|root,COG1747@1|root,COG0782@2|Bacteria,COG1747@2|Bacteria,2J5MW@203691|Spirochaetes	203691|Spirochaetes	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	-	-	-	-	-	-	-	-	-	GreA_GreB,GreA_GreB_N
SX3_k127_4317192_9	1123274.KB899421_gene1770	2.84e-48	196.0	COG2304@1|root,COG2304@2|Bacteria,2J67D@203691|Spirochaetes	203691|Spirochaetes	K	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
SX3_k127_4317192_8	889378.Spiaf_1529	3.545e-49	193.0	COG1413@1|root,COG1413@2|Bacteria,2J5WK@203691|Spirochaetes	203691|Spirochaetes	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
SX3_k127_4317192_3	1123274.KB899421_gene1768	8.328e-117	397.0	COG0728@1|root,COG0728@2|Bacteria,2J697@203691|Spirochaetes	203691|Spirochaetes	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
SX3_k127_4317192_11	545695.TREAZ_1588	7.333e-27	119.0	COG0791@1|root,COG0791@2|Bacteria,2J68J@203691|Spirochaetes	203691|Spirochaetes	M	NlpC P60 family	-	-	-	ko:K13695,ko:K19303	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60
SX3_k127_4317192_2	665571.STHERM_c11100	6.634e-137	454.0	COG0343@1|root,COG0343@2|Bacteria,2J5U0@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
SX3_k127_4317192_7	443143.GM18_1183	1.16e-61	224.0	COG1940@1|root,COG1940@2|Bacteria,1MU94@1224|Proteobacteria,42RF4@68525|delta/epsilon subdivisions,2WPIV@28221|Deltaproteobacteria,43TWB@69541|Desulfuromonadales	28221|Deltaproteobacteria	GK	PFAM ROK family protein	glkA	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
SX3_k127_4317192_6	744872.Spica_1361	7.584e-78	273.0	COG0795@1|root,COG0795@2|Bacteria,2J64B@203691|Spirochaetes	203691|Spirochaetes	S	Permease, YjgP YjgQ family	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
SX3_k127_4317192_4	545694.TREPR_1763	3.391e-90	312.0	COG0795@1|root,COG0795@2|Bacteria,2J5F9@203691|Spirochaetes	203691|Spirochaetes	S	Permease YjgP YjgQ family	-	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
SX3_k127_4317192_12	1169161.KB897719_gene3614	1.899e-10	74.0	COG3292@1|root,COG3292@2|Bacteria,2H1QS@201174|Actinobacteria	201174|Actinobacteria	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	Reg_prop
SX3_k127_4317192_10	906968.Trebr_1252	1.343e-47	174.0	COG0756@1|root,COG0756@2|Bacteria,2J7JH@203691|Spirochaetes	203691|Spirochaetes	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
SX3_k127_4317192_5	906968.Trebr_1964	1.41e-81	287.0	COG0612@1|root,COG0612@2|Bacteria,2J6UV@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the peptidase M16 family	pqqL	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
SX3_k127_4317192_0	573413.Spirs_2033	8.187e-286	895.0	COG1185@1|root,COG1185@2|Bacteria,2J5BU@203691|Spirochaetes	203691|Spirochaetes	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
SX3_k127_4344755_47	744872.Spica_1490	8.93e-05	47.0	COG1550@1|root,COG1550@2|Bacteria,2J8FX@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF503)	-	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
SX3_k127_4344755_11	744872.Spica_1492	8.41e-109	368.0	COG4254@1|root,COG4254@2|Bacteria,2J99I@203691|Spirochaetes	203691|Spirochaetes	S	PFAM FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4344755_2	665571.STHERM_c06640	2.719e-160	530.0	COG4254@1|root,COG4254@2|Bacteria,2J9KS@203691|Spirochaetes	203691|Spirochaetes	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
SX3_k127_4344755_8	1307761.L21SP2_1649	2.372e-126	424.0	COG0323@1|root,COG0323@2|Bacteria,2J5XE@203691|Spirochaetes	203691|Spirochaetes	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
SX3_k127_4344755_12	1123274.KB899424_gene3003	3.017e-100	351.0	COG0457@1|root,COG0457@2|Bacteria,2J5NB@203691|Spirochaetes	203691|Spirochaetes	S	tetratricopeptide repeat	lmp1	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_6,TPR_7,TPR_8
SX3_k127_4344755_39	1125725.HMPREF1325_0176	1.414e-27	122.0	COG0457@1|root,COG0457@2|Bacteria,2J7SI@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_19,TPR_7,TPR_8
SX3_k127_4344755_21	1123274.KB899424_gene3006	1.585e-77	265.0	COG2129@1|root,COG2129@2|Bacteria,2J5J9@203691|Spirochaetes	203691|Spirochaetes	S	metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
SX3_k127_4344755_15	889378.Spiaf_1447	2.523e-88	300.0	COG1475@1|root,COG1475@2|Bacteria,2J6CV@203691|Spirochaetes	203691|Spirochaetes	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4344755_37	1333998.M2A_1532	1.14e-31	127.0	COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,2U9BY@28211|Alphaproteobacteria,4BQKT@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
SX3_k127_4344755_1	665571.STHERM_c07150	3.551e-269	854.0	COG5009@1|root,COG5009@2|Bacteria,2J5D4@203691|Spirochaetes	203691|Spirochaetes	M	penicillin-binding protein	pbp-3	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
SX3_k127_4344755_27	573413.Spirs_1730	1.577e-65	235.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,2J7KD@203691|Spirochaetes	203691|Spirochaetes	M	M23 M37 peptidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23
SX3_k127_4344755_36	573413.Spirs_1732	6.338e-32	143.0	COG0457@1|root,COG0457@2|Bacteria,2J8XX@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_8
SX3_k127_4344755_16	744872.Spica_2754	2.048e-83	291.0	COG1463@1|root,COG1463@2|Bacteria,2J7MR@203691|Spirochaetes	203691|Spirochaetes	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
SX3_k127_4344755_29	665571.STHERM_c07220	2.654e-58	211.0	COG1135@1|root,COG1135@2|Bacteria,2J7XY@203691|Spirochaetes	203691|Spirochaetes	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
SX3_k127_4344755_19	665571.STHERM_c07230	4.443e-82	285.0	COG0767@1|root,COG0767@2|Bacteria,2J7BX@203691|Spirochaetes	203691|Spirochaetes	Q	ABC-type transport system involved in resistance to organic solvents permease component	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
SX3_k127_4344755_25	545694.TREPR_3813	2.024e-66	248.0	COG0613@1|root,COG0613@2|Bacteria,2J69S@203691|Spirochaetes	203691|Spirochaetes	S	PHP domain protein	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
SX3_k127_4344755_10	643648.Slip_1740	1.197e-111	374.0	COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,2488G@186801|Clostridia,42JNW@68298|Syntrophomonadaceae	186801|Clostridia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
SX3_k127_4344755_18	665571.STHERM_c15820	4.229e-82	291.0	COG0337@1|root,COG0337@2|Bacteria,2J69J@203691|Spirochaetes	203691|Spirochaetes	H	3-dehydroquinate synthase	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
SX3_k127_4344755_41	744872.Spica_0136	6.29e-24	109.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	cNMP_binding
SX3_k127_4344755_0	744872.Spica_1303	8.965e-290	918.0	COG1643@1|root,COG1643@2|Bacteria,2J58M@203691|Spirochaetes	203691|Spirochaetes	L	Helicase	hrpA	-	-	-	-	-	-	-	-	-	-	-	DEAD,HA2,Helicase_C,OB_NTP_bind
SX3_k127_4344755_9	502025.Hoch_5472	3.72e-116	387.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,42MWJ@68525|delta/epsilon subdivisions,2WJ8Q@28221|Deltaproteobacteria,2YYM7@29|Myxococcales	28221|Deltaproteobacteria	O	Belongs to the ClpX chaperone family	-	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small
SX3_k127_4344755_35	575540.Isop_1780	3.481e-32	138.0	COG2234@1|root,COG2234@2|Bacteria,2IY4A@203682|Planctomycetes	203682|Planctomycetes	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
SX3_k127_4344755_3	573413.Spirs_1904	2.158e-154	499.0	COG0124@1|root,COG0124@2|Bacteria,2J5DX@203691|Spirochaetes	203691|Spirochaetes	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
SX3_k127_4344755_23	1125701.HMPREF1221_00436	1.598e-75	270.0	COG0617@1|root,COG0617@2|Bacteria,2J5VH@203691|Spirochaetes	203691|Spirochaetes	H	Belongs to the tRNA nucleotidyltransferase poly(A) polymerase family	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd
SX3_k127_4344755_22	1307761.L21SP2_0814	1.789e-76	271.0	COG0457@1|root,COG0457@2|Bacteria,2J6MJ@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF1570
SX3_k127_4344755_30	1123274.KB899415_gene2516	1.756e-51	192.0	COG0714@1|root,COG1302@1|root,COG0714@2|Bacteria,COG1302@2|Bacteria,2J6I6@203691|Spirochaetes	203691|Spirochaetes	S	Associated with various cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4344755_6	1047013.AQSP01000138_gene1035	1.297e-143	470.0	COG1032@1|root,COG1032@2|Bacteria,2NQU0@2323|unclassified Bacteria	2|Bacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
SX3_k127_4344755_32	1480694.DC28_14730	9.097e-42	159.0	COG1963@1|root,COG1963@2|Bacteria,2J7WX@203691|Spirochaetes	203691|Spirochaetes	S	Divergent PAP2 family	-	-	-	ko:K09775	-	-	-	-	ko00000	-	-	-	DUF212
SX3_k127_4344755_13	1123274.KB899415_gene2518	5.753e-97	337.0	COG4656@1|root,COG4656@2|Bacteria,2J5TG@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily	rnfC	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_8,RnfC_N,SLBB
SX3_k127_4344755_20	573413.Spirs_1910	1.366e-79	286.0	COG4658@1|root,COG4658@2|Bacteria,2J639@203691|Spirochaetes	203691|Spirochaetes	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
SX3_k127_4344755_38	1123274.KB899415_gene2521	3.859e-30	127.0	COG4660@1|root,COG4660@2|Bacteria,2J58U@203691|Spirochaetes	203691|Spirochaetes	C	Part of a membrane complex involved in electron transport	rsxE	-	-	ko:K03613	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
SX3_k127_4344755_34	573413.Spirs_1913	8.454e-34	146.0	COG4657@1|root,COG4657@2|Bacteria,2J5ES@203691|Spirochaetes	203691|Spirochaetes	C	Part of a membrane complex involved in electron transport	rnfA	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
SX3_k127_4344755_4	1123274.KB899415_gene2524	9.243e-154	508.0	COG1449@1|root,COG1449@2|Bacteria,2J5C8@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 57 family	-	-	2.4.1.25	ko:K22451	ko00500,map00500	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH57	-	DUF1925,DUF1926,Glyco_hydro_57
SX3_k127_4344755_33	1123274.KB899415_gene2525	2.446e-39	165.0	COG1729@1|root,COG1729@2|Bacteria,2J6ZY@203691|Spirochaetes	203691|Spirochaetes	S	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4344755_43	744872.Spica_1233	3.298e-22	100.0	2FK3B@1|root,34BRF@2|Bacteria,2J8AH@203691|Spirochaetes	203691|Spirochaetes	S	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette	-	-	-	ko:K09951	-	-	-	-	ko00000,ko02048	-	-	-	CRISPR_Cas2
SX3_k127_4344755_5	1307761.L21SP2_0826	2.379e-145	469.0	COG1186@1|root,COG1186@2|Bacteria,2J5QR@203691|Spirochaetes	203691|Spirochaetes	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
SX3_k127_4344755_31	1123239.KB898623_gene1195	5.393e-44	163.0	COG2201@1|root,COG2201@2|Bacteria,1V3IU@1239|Firmicutes,4HGY2@91061|Bacilli	91061|Bacilli	T	Chemotaxis protein CheY	cheY	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
SX3_k127_4344755_44	195522.BD01_0726	2.287e-11	77.0	COG0515@1|root,COG3889@1|root,arCOG03264@1|root,arCOG01672@2157|Archaea,arCOG03264@2157|Archaea,arCOG03682@2157|Archaea,2Y2TW@28890|Euryarchaeota,243EY@183968|Thermococci	183968|Thermococci	E	solute binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
SX3_k127_4344755_17	573413.Spirs_1921	2.236e-82	283.0	COG0552@1|root,COG0552@2|Bacteria,2J5KQ@203691|Spirochaetes	203691|Spirochaetes	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
SX3_k127_4344755_14	573413.Spirs_1923	2.331e-94	329.0	COG4591@1|root,COG4591@2|Bacteria,2J5D9@203691|Spirochaetes	203691|Spirochaetes	M	ABC-type transport system involved in lipoprotein release permease component	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
SX3_k127_4344755_26	1480694.DC28_14650	3.901e-66	234.0	COG1136@1|root,COG1136@2|Bacteria,2J6WT@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
SX3_k127_4344755_24	907348.TresaDRAFT_1094	2.679e-68	249.0	COG4591@1|root,COG4591@2|Bacteria,2J5WV@203691|Spirochaetes	203691|Spirochaetes	M	Permease protein	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
SX3_k127_4344755_40	521460.Athe_1827	2.432e-26	115.0	COG3880@1|root,COG3880@2|Bacteria,1V6YM@1239|Firmicutes,24JE8@186801|Clostridia,42G0X@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM UvrB UvrC protein	mcsA	-	-	ko:K19411	-	-	-	-	ko00000	-	-	-	UVR
SX3_k127_4344755_28	1123226.KB899300_gene2809	1.253e-63	232.0	COG3869@1|root,COG3869@2|Bacteria,1TPBA@1239|Firmicutes,4HC6U@91061|Bacilli,26T89@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the specific phosphorylation of arginine residues in proteins	mcsB	GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170	2.7.14.1	ko:K19405	-	-	R11090	RC00002,RC00203	ko00000,ko01000	-	-	-	ATP-gua_Ptrans
SX3_k127_4344755_45	1307761.L21SP2_0836	9.158e-08	59.0	COG0542@1|root,COG0542@2|Bacteria,2J5B9@203691|Spirochaetes	203691|Spirochaetes	O	ATPase family associated with various cellular activities (AAA)	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
SX3_k127_4396113_2	665571.STHERM_c05610	6.985e-54	202.0	COG2199@1|root,COG3706@2|Bacteria,2J5A2@203691|Spirochaetes	203691|Spirochaetes	T	Diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
SX3_k127_4396113_0	1480694.DC28_08415	2.924e-238	756.0	COG0077@1|root,COG2876@1|root,COG0077@2|Bacteria,COG2876@2|Bacteria,2J644@203691|Spirochaetes	203691|Spirochaetes	H	PFAM DAHP synthetase I KDSA	pheA	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,DAHP_synth_1,PDT
SX3_k127_4396113_6	1439940.BAY1663_04142	6.933e-06	56.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0006457,GO:0008150,GO:0009987	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
SX3_k127_4396113_1	573413.Spirs_0276	2.035e-72	262.0	2EW9N@1|root,33PNA@2|Bacteria,2J5CY@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4396113_3	573413.Spirs_0277	9.64e-46	171.0	2CA4A@1|root,32RQK@2|Bacteria,2J92B@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF4416)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4416
SX3_k127_4396113_4	545695.TREAZ_1630	3.712e-28	117.0	COG0006@1|root,COG0006@2|Bacteria,2J5QB@203691|Spirochaetes	203691|Spirochaetes	E	peptidase	-	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C
SX3_k127_4455973_1	744872.Spica_1191	1.454e-103	340.0	COG2872@1|root,COG2872@2|Bacteria	2|Bacteria	S	Ser-tRNA(Ala) hydrolase activity	alaXM	GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872,ko:K07050	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
SX3_k127_4455973_6	743525.TSC_c11130	2.335e-16	90.0	COG4299@1|root,COG4299@2|Bacteria,1WJPW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Domain of unknown function (DUF5009)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624,DUF5009
SX3_k127_4455973_4	880073.Calab_3447	5.253e-39	167.0	COG1373@1|root,COG1373@2|Bacteria,2NP9F@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF4143)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_14,DUF4143
SX3_k127_4455973_0	573413.Spirs_1216	6.577e-278	874.0	COG1472@1|root,COG1472@2|Bacteria,2J9XZ@203691|Spirochaetes	203691|Spirochaetes	G	hydrolase, family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
SX3_k127_4455973_3	485913.Krac_3525	1.674e-39	167.0	COG0395@1|root,COG0395@2|Bacteria,2G8MN@200795|Chloroflexi	200795|Chloroflexi	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
SX3_k127_4455973_2	1238184.CM001792_gene850	3.048e-44	175.0	COG1175@1|root,COG1175@2|Bacteria,1UZJA@1239|Firmicutes,4HEW1@91061|Bacilli,23KVR@182709|Oceanobacillus	91061|Bacilli	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
SX3_k127_4455973_5	608506.COB47_0569	1.209e-37	157.0	COG1653@1|root,COG1653@2|Bacteria,1TR5H@1239|Firmicutes,24C14@186801|Clostridia,42JBA@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM extracellular solute-binding protein family 1	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8
SX3_k127_4455973_7	744872.Spica_0308	4.415e-15	75.0	COG2197@1|root,COG2197@2|Bacteria,2J8HI@203691|Spirochaetes	203691|Spirochaetes	K	COGs COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	ko:K11618	ko02020,map02020	M00481,M00754	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
SX3_k127_4471886_2	1123274.KB899411_gene3093	8.903e-202	634.0	COG0201@1|root,COG0201@2|Bacteria,2J5BH@203691|Spirochaetes	203691|Spirochaetes	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
SX3_k127_4471886_54	573413.Spirs_0976	1.337e-11	65.0	COG0257@1|root,COG0257@2|Bacteria,2J989@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
SX3_k127_4471886_34	1480694.DC28_14255	1.752e-58	204.0	COG0099@1|root,COG0099@2|Bacteria,2J7QU@203691|Spirochaetes	203691|Spirochaetes	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
SX3_k127_4471886_35	1480694.DC28_14250	4.56e-55	195.0	COG0100@1|root,COG0100@2|Bacteria,2J7BP@203691|Spirochaetes	203691|Spirochaetes	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
SX3_k127_4471886_27	573413.Spirs_0979	1.021e-85	289.0	COG0522@1|root,COG0522@2|Bacteria,2J6UK@203691|Spirochaetes	203691|Spirochaetes	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
SX3_k127_4471886_7	573413.Spirs_0980	4.348e-154	494.0	COG0202@1|root,COG0202@2|Bacteria,2J58K@203691|Spirochaetes	203691|Spirochaetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
SX3_k127_4471886_40	665571.STHERM_c05220	8.018e-42	159.0	COG0203@1|root,COG0203@2|Bacteria,2J841@203691|Spirochaetes	203691|Spirochaetes	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
SX3_k127_4471886_47	1125725.HMPREF1325_2386	2.14e-26	127.0	COG3064@1|root,COG3064@2|Bacteria,2J6Q1@203691|Spirochaetes	203691|Spirochaetes	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4471886_1	744872.Spica_2759	8.247e-231	724.0	COG1418@1|root,COG1418@2|Bacteria,2J5IM@203691|Spirochaetes	203691|Spirochaetes	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
SX3_k127_4471886_21	1123274.KB899431_gene3253	7.105e-100	333.0	COG1692@1|root,COG1692@2|Bacteria,2J7C4@203691|Spirochaetes	203691|Spirochaetes	S	metallophosphoesterase	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
SX3_k127_4471886_36	1123274.KB899431_gene3254	8.644e-54	199.0	COG1189@1|root,COG1189@2|Bacteria,2J8G3@203691|Spirochaetes	203691|Spirochaetes	J	TIGRFAM hemolysin TlyA family protein	tlyA	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
SX3_k127_4471886_45	744872.Spica_2757	2.341e-33	139.0	COG5401@1|root,COG5401@2|Bacteria,2J7JQ@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane
SX3_k127_4471886_3	889378.Spiaf_1972	3.222e-190	610.0	COG1080@1|root,COG1080@2|Bacteria,2J5FB@203691|Spirochaetes	203691|Spirochaetes	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
SX3_k127_4471886_10	665571.STHERM_c12980	9.976e-133	439.0	COG1160@1|root,COG1160@2|Bacteria,2J5GG@203691|Spirochaetes	203691|Spirochaetes	I	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
SX3_k127_4471886_49	545695.TREAZ_1699	2.212e-20	106.0	COG0789@1|root,COG0789@2|Bacteria,2J82G@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator, MerR family	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
SX3_k127_4471886_18	649638.Trad_0907	5.712e-109	376.0	COG4284@1|root,COG4284@2|Bacteria	2|Bacteria	G	Utp--glucose-1-phosphate uridylyltransferase	CP_1013	-	2.7.7.23,2.7.7.83	ko:K00972,ko:K11442	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00361,M00362	R00416	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPGP
SX3_k127_4471886_29	1307761.L21SP2_1346	5.988e-79	280.0	2F2JP@1|root,33VGK@2|Bacteria,2J6EC@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4471886_11	573413.Spirs_3206	1.105e-121	427.0	COG1729@1|root,COG3071@1|root,COG4105@1|root,COG1729@2|Bacteria,COG3071@2|Bacteria,COG4105@2|Bacteria,2J6SG@203691|Spirochaetes	203691|Spirochaetes	H	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
SX3_k127_4471886_50	1123274.KB899431_gene3261	2.287e-19	104.0	2CA9B@1|root,34495@2|Bacteria,2J5SX@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4471886_30	1123274.KB899431_gene3262	1.961e-74	255.0	COG0811@1|root,COG0811@2|Bacteria,2J700@203691|Spirochaetes	203691|Spirochaetes	U	MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
SX3_k127_4471886_44	744872.Spica_2113	2.015e-35	139.0	COG0848@1|root,COG0848@2|Bacteria,2J82R@203691|Spirochaetes	203691|Spirochaetes	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
SX3_k127_4471886_56	485915.Dret_1657	0.0005037	51.0	COG0810@1|root,COG0810@2|Bacteria,1NDQZ@1224|Proteobacteria,42VIY@68525|delta/epsilon subdivisions,2WRTC@28221|Deltaproteobacteria,2MDBG@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
SX3_k127_4471886_4	1123274.KB899431_gene3266	8.599e-173	576.0	COG1196@1|root,COG1196@2|Bacteria,2J5RV@203691|Spirochaetes	203691|Spirochaetes	D	PFAM secretion protein HlyD family protein	-	-	-	-	-	-	-	-	-	-	-	-	Apolipoprotein,HTH_38
SX3_k127_4471886_28	903814.ELI_3312	2.134e-81	285.0	COG1146@1|root,COG2006@1|root,COG1146@2|Bacteria,COG2006@2|Bacteria,1TRX2@1239|Firmicutes,249GX@186801|Clostridia,25VVJ@186806|Eubacteriaceae	186801|Clostridia	C	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Fer4_10,Fer4_7
SX3_k127_4471886_13	1125863.JAFN01000001_gene389	4.216e-120	401.0	COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,42MNB@68525|delta/epsilon subdivisions,2WIXQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Belongs to the GPI family	pgi	-	2.2.1.2,5.3.1.9	ko:K01810,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
SX3_k127_4471886_39	1123274.KB899431_gene3267	6.413e-48	181.0	COG0576@1|root,COG0576@2|Bacteria,2J7UP@203691|Spirochaetes	203691|Spirochaetes	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
SX3_k127_4471886_0	1539298.JO41_07970	2.553e-277	866.0	COG0443@1|root,COG0443@2|Bacteria,2J5I0@203691|Spirochaetes	203691|Spirochaetes	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
SX3_k127_4471886_6	573413.Spirs_3197	8.152e-159	518.0	COG0484@1|root,COG0484@2|Bacteria,2J614@203691|Spirochaetes	203691|Spirochaetes	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
SX3_k127_4471886_53	713586.KB900536_gene1353	2.79e-14	85.0	COG0642@1|root,COG2205@2|Bacteria,1MXF8@1224|Proteobacteria,1RMMI@1236|Gammaproteobacteria,1X2Q0@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS_8
SX3_k127_4471886_16	986075.CathTA2_1042	2.371e-110	367.0	COG3426@1|root,COG3426@2|Bacteria,1TPKE@1239|Firmicutes,4H9QV@91061|Bacilli	91061|Bacilli	C	Belongs to the acetokinase family	buk	-	2.7.2.7	ko:K00929	ko00650,ko01100,map00650,map01100	-	R01688	RC00002,RC00043	ko00000,ko00001,ko01000	-	-	-	Acetate_kinase
SX3_k127_4471886_55	1167006.UWK_01787	7.705e-06	56.0	COG2770@1|root,COG2770@2|Bacteria,1R08R@1224|Proteobacteria,43CRE@68525|delta/epsilon subdivisions,2X7Z3@28221|Deltaproteobacteria,2MPM2@213118|Desulfobacterales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4471886_31	292459.STH1435	3.946e-69	248.0	COG3392@1|root,COG3392@2|Bacteria,1TRWE@1239|Firmicutes,248Q7@186801|Clostridia	186801|Clostridia	L	D12 class N6 adenine-specific DNA methyltransferase	fokIM	-	2.1.1.72	ko:K07318	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	MethyltransfD12
SX3_k127_4471886_19	292459.STH1434	1.574e-107	357.0	COG0863@1|root,COG0863@2|Bacteria	2|Bacteria	L	N-4 methylation of cytosine	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
SX3_k127_4471886_52	665571.STHERM_c18670	7.384e-18	90.0	COG2849@1|root,COG2849@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	MORN_2,TonB_C
SX3_k127_4471886_33	573413.Spirs_3194	3.265e-65	230.0	COG0566@1|root,COG0566@2|Bacteria,2J748@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	yacO	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
SX3_k127_4471886_37	926569.ANT_17620	8.002e-53	192.0	COG1309@1|root,COG1309@2|Bacteria,2G7DR@200795|Chloroflexi	200795|Chloroflexi	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_4,TetR_N
SX3_k127_4471886_25	926569.ANT_17630	3.074e-92	325.0	COG0451@1|root,COG0451@2|Bacteria,2G84M@200795|Chloroflexi	200795|Chloroflexi	M	PFAM NAD-dependent epimerase dehydratase	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
SX3_k127_4471886_42	1210884.HG799463_gene10060	1.084e-38	164.0	COG0300@1|root,COG0300@2|Bacteria,2IZMH@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
SX3_k127_4471886_46	1150474.JQJI01000009_gene1285	1.306e-32	143.0	COG0041@1|root,COG0041@2|Bacteria,2GDB5@200918|Thermotogae	200918|Thermotogae	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
SX3_k127_4471886_14	889378.Spiaf_1956	6.335e-119	396.0	COG0151@1|root,COG0151@2|Bacteria	2|Bacteria	F	phosphoribosylamine-glycine ligase activity	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
SX3_k127_4471886_38	1307761.L21SP2_1361	9.45e-49	183.0	COG0299@1|root,COG0299@2|Bacteria	2|Bacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N,YjbR
SX3_k127_4471886_20	1307761.L21SP2_1362	1.252e-106	355.0	COG0150@1|root,COG0150@2|Bacteria,2J5AP@203691|Spirochaetes	203691|Spirochaetes	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
SX3_k127_4471886_5	889378.Spiaf_1953	7.06e-167	541.0	COG0034@1|root,COG0034@2|Bacteria,2J5Y2@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
SX3_k127_4471886_8	1123371.ATXH01000034_gene765	2.438e-145	478.0	COG2256@1|root,COG2256@2|Bacteria,2GGYY@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	AAA C-terminal domain	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
SX3_k127_4471886_22	1125725.HMPREF1325_0111	1.938e-99	334.0	COG0042@1|root,COG0042@2|Bacteria,2J691@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	-	-	-	-	-	-	-	-	-	-	-	-	Dus
SX3_k127_4471886_12	1123274.KB899431_gene3275	1.519e-121	394.0	COG0084@1|root,COG0084@2|Bacteria,2J68W@203691|Spirochaetes	203691|Spirochaetes	L	Hydrolase, TatD family	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
SX3_k127_4471886_32	596324.TREVI0001_0790	1.817e-67	242.0	COG0739@1|root,COG0739@2|Bacteria,2J5SN@203691|Spirochaetes	203691|Spirochaetes	M	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
SX3_k127_4471886_43	1123274.KB899431_gene3277	4.615e-38	158.0	COG1664@1|root,COG1664@2|Bacteria,2J82J@203691|Spirochaetes	203691|Spirochaetes	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
SX3_k127_4471886_48	744872.Spica_0042	2.222e-25	114.0	COG1728@1|root,COG1728@2|Bacteria,2J8W0@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF327)	-	-	-	ko:K09770	-	-	-	-	ko00000	-	-	-	DUF327
SX3_k127_4471886_26	1123274.KB899431_gene3279	2.156e-90	309.0	COG1774@1|root,COG1774@2|Bacteria,2J5RE@203691|Spirochaetes	203691|Spirochaetes	S	PFAM PSP1 C-terminal conserved region	-	-	-	-	-	-	-	-	-	-	-	-	PSP1
SX3_k127_4471886_23	697281.Mahau_2214	3.42e-98	347.0	2DBSS@1|root,2ZATI@2|Bacteria,1V13H@1239|Firmicutes,24D92@186801|Clostridia,42J9A@68295|Thermoanaerobacterales	186801|Clostridia	S	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
SX3_k127_4471886_15	608506.COB47_2138	2.348e-117	394.0	COG3225@1|root,COG3225@2|Bacteria,1TT1J@1239|Firmicutes,24BC2@186801|Clostridia,42FP0@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM ABC-type uncharacterised transport system	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3,ABC_transp_aux
SX3_k127_4471886_24	1304880.JAGB01000002_gene2266	1.036e-94	319.0	COG1277@1|root,COG1277@2|Bacteria,1UZXS@1239|Firmicutes,248ME@186801|Clostridia	186801|Clostridia	N	Psort location CytoplasmicMembrane, score	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_2,ABC2_membrane_3,ABC2_membrane_5
SX3_k127_4471886_9	1304880.JAGB01000002_gene2267	3.5e-134	435.0	COG1131@1|root,COG1131@2|Bacteria,1TQUS@1239|Firmicutes,25AZ1@186801|Clostridia	186801|Clostridia	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_4471886_41	665956.HMPREF1032_01280	3.787e-40	159.0	COG1011@1|root,COG1011@2|Bacteria,1TWM7@1239|Firmicutes,24HKY@186801|Clostridia,3WJVM@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	3.8.1.2	ko:K01560,ko:K07025	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
SX3_k127_4471886_51	744872.Spica_1612	1.677e-18	87.0	2ERI0@1|root,33J3G@2|Bacteria,2J8XU@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4471886_17	1121441.AUCX01000010_gene274	4.273e-110	374.0	COG1262@1|root,COG4249@1|root,COG1262@2|Bacteria,COG4249@2|Bacteria,1NQ5K@1224|Proteobacteria,42MAT@68525|delta/epsilon subdivisions,2WKY9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,Peptidase_C14
SX3_k127_4477885_5	1121287.AUMU01000009_gene2299	1.007e-06	60.0	COG2197@1|root,COG2197@2|Bacteria,4NQIG@976|Bacteroidetes,1I4JG@117743|Flavobacteriia,3ZRB8@59732|Chryseobacterium	976|Bacteroidetes	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
SX3_k127_4477885_1	545694.TREPR_2780	1.324e-88	319.0	COG0457@1|root,COG1652@1|root,COG0457@2|Bacteria,COG1652@2|Bacteria,2J7YH@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4477885_3	660470.Theba_2456	3.853e-26	121.0	COG1262@1|root,COG1262@2|Bacteria,2GEAZ@200918|Thermotogae	200918|Thermotogae	O	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PDZ_2
SX3_k127_4477885_0	269799.Gmet_1507	1.061e-89	318.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,42TQ5@68525|delta/epsilon subdivisions,2WQ0T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SX3_k127_4477885_4	933262.AXAM01000001_gene369	6.665e-23	100.0	2ANKS@1|root,31DJZ@2|Bacteria,1R1SV@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4508014_12	269797.Mbar_A3441	4.47e-83	282.0	COG0535@1|root,arCOG00938@2157|Archaea,2Y8D5@28890|Euryarchaeota,2NBPE@224756|Methanomicrobia	224756|Methanomicrobia	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM
SX3_k127_4508014_28	1122605.KB893626_gene2671	1.764e-22	110.0	COG4667@1|root,COG4667@2|Bacteria	2|Bacteria	S	lipid catabolic process	yjjU	GO:0003674,GO:0003824,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016787,GO:0033554,GO:0050896,GO:0051716	-	-	-	-	-	-	-	-	-	-	Patatin
SX3_k127_4508014_6	926569.ANT_08150	5.855e-105	352.0	COG1131@1|root,COG1131@2|Bacteria,2G5WA@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_4508014_26	316274.Haur_1890	5.25e-24	117.0	COG0842@1|root,COG1511@1|root,COG0842@2|Bacteria,COG1511@2|Bacteria,2G774@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
SX3_k127_4508014_22	316274.Haur_1889	2.17e-38	158.0	COG0842@1|root,COG0842@2|Bacteria,2G8VC@200795|Chloroflexi	200795|Chloroflexi	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
SX3_k127_4508014_31	720554.Clocl_0354	3.723e-05	46.0	COG1484@1|root,COG1484@2|Bacteria,1V669@1239|Firmicutes,24I8H@186801|Clostridia,3WRXB@541000|Ruminococcaceae	186801|Clostridia	L	PFAM IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
SX3_k127_4508014_21	1244869.H261_08508	7.662e-41	154.0	COG2337@1|root,COG2337@2|Bacteria,1N0C3@1224|Proteobacteria,2UDRU@28211|Alphaproteobacteria,2JUM6@204441|Rhodospirillales	204441|Rhodospirillales	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
SX3_k127_4508014_32	1515746.HR45_19210	8.419e-05	48.0	COG2002@1|root,COG2002@2|Bacteria,1RIAX@1224|Proteobacteria,1SC9R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Antitoxin component of a type II toxin-antitoxin (TA) system. Labile antitoxin that binds to the YhaV toxin and neutralizes its ribonuclease activity. Also acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression	sohA	GO:0001558,GO:0003674,GO:0003700,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0040008,GO:0042802,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097351,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K19156	-	-	-	-	ko00000,ko02048	-	-	-	PrlF_antitoxin
SX3_k127_4508014_25	316274.Haur_1889	1.996e-25	111.0	COG0842@1|root,COG0842@2|Bacteria,2G8VC@200795|Chloroflexi	200795|Chloroflexi	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
SX3_k127_4508014_7	177439.DP2458	1.044e-104	355.0	COG1482@1|root,COG1482@2|Bacteria,1MUD8@1224|Proteobacteria,42QR1@68525|delta/epsilon subdivisions,2WU24@28221|Deltaproteobacteria,2MMJP@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Phosphomannose isomerase type I	-	-	5.3.1.8,5.4.2.8	ko:K01809,ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818,R01819	RC00376,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PMI_typeI
SX3_k127_4508014_11	945713.IALB_0467	1.633e-85	293.0	COG1801@1|root,COG1801@2|Bacteria	2|Bacteria	L	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
SX3_k127_4508014_17	290397.Adeh_1286	2.493e-60	222.0	COG0454@1|root,COG0456@2|Bacteria,1RD40@1224|Proteobacteria,43EF3@68525|delta/epsilon subdivisions,2X0ID@28221|Deltaproteobacteria,2Z1N2@29|Myxococcales	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SX3_k127_4508014_15	264462.Bd3476	4.254e-68	244.0	COG1816@1|root,COG1816@2|Bacteria,1MWBV@1224|Proteobacteria,42UJZ@68525|delta/epsilon subdivisions,2MTST@213481|Bdellovibrionales,2WQCC@28221|Deltaproteobacteria	213481|Bdellovibrionales	F	adenosine deaminase	add	-	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
SX3_k127_4508014_23	378806.STAUR_0585	2.415e-38	149.0	COG1595@1|root,COG1595@2|Bacteria,1RHSF@1224|Proteobacteria,438JV@68525|delta/epsilon subdivisions,2X3UH@28221|Deltaproteobacteria,2YX4W@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	HTH_24,Sigma70_r2,Sigma70_r4_2
SX3_k127_4508014_29	1121456.ATVA01000014_gene776	1.231e-19	93.0	COG2204@1|root,COG2208@1|root,COG2204@2|Bacteria,COG2208@2|Bacteria,1N4K5@1224|Proteobacteria,42Z10@68525|delta/epsilon subdivisions,2WU0N@28221|Deltaproteobacteria,2M9PY@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	protein phosphatase 2C domain protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Response_reg,SpoIIE
SX3_k127_4508014_2	1191523.MROS_2212	1.77e-159	531.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
SX3_k127_4508014_8	443144.GM21_1870	7.064e-102	364.0	COG2984@1|root,COG4191@1|root,COG2984@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WM1A@28221|Deltaproteobacteria,43TUP@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,PocR,Response_reg,SBP_bac_3,sCache_2
SX3_k127_4508014_30	2045.KR76_03520	7.287e-14	83.0	COG1609@1|root,COG1609@2|Bacteria,2GKFC@201174|Actinobacteria,4DPN2@85009|Propionibacteriales	201174|Actinobacteria	K	Periplasmic binding protein-like domain	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
SX3_k127_4508014_20	697281.Mahau_1337	3.18e-44	171.0	COG1414@1|root,COG1414@2|Bacteria,1TRMW@1239|Firmicutes,24BQA@186801|Clostridia,42G3H@68295|Thermoanaerobacterales	186801|Clostridia	K	Transcriptional regulator IclR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
SX3_k127_4508014_24	794903.OPIT5_22635	7.566e-29	126.0	COG1028@1|root,COG1028@2|Bacteria	794903.OPIT5_22635|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4508014_19	1499967.BAYZ01000022_gene248	2.96e-49	181.0	COG3194@1|root,COG3194@2|Bacteria	2|Bacteria	F	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source	allA	GO:0003674,GO:0003824,GO:0016829,GO:0016840,GO:0016842,GO:0050385	4.3.2.3	ko:K01483	ko00230,ko01100,map00230,map01100	-	R00776	RC00153,RC00379	ko00000,ko00001,ko01000	-	-	iAF1260.b0505,iBWG_1329.BWG_0382,iECDH10B_1368.ECDH10B_0461,iECDH1ME8569_1439.ECDH1ME8569_0489,iEcDH1_1363.EcDH1_3107,iJO1366.b0505,iJR904.b0505,iY75_1357.Y75_RS02595	Ureidogly_lyase
SX3_k127_4508014_3	1051646.VITU9109_15913	8.384e-139	449.0	COG1879@1|root,COG1879@2|Bacteria,1QKY2@1224|Proteobacteria,1TJ44@1236|Gammaproteobacteria,1Y0H8@135623|Vibrionales	135623|Vibrionales	G	Ribose ABC transporter substrate-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_4
SX3_k127_4508014_0	1499967.BAYZ01000012_gene2478	4.013e-238	744.0	COG1129@1|root,COG1129@2|Bacteria,2NPR8@2323|unclassified Bacteria	2|Bacteria	G	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
SX3_k127_4508014_4	1051646.VITU9109_15903	1.521e-115	382.0	COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,1TCBB@1236|Gammaproteobacteria,1Y0JV@135623|Vibrionales	135623|Vibrionales	G	Sugar ABC transporter permease	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
SX3_k127_4508014_10	1051646.VITU9109_15898	1.241e-99	336.0	COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,1TCBA@1236|Gammaproteobacteria,1Y04D@135623|Vibrionales	135623|Vibrionales	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
SX3_k127_4508014_16	180332.JTGN01000016_gene985	2.442e-67	248.0	28MXM@1|root,2ZB4M@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4508014_1	1499967.BAYZ01000012_gene2471	1.153e-198	636.0	COG1070@1|root,COG1070@2|Bacteria	2|Bacteria	G	xylulokinase activity	-	-	2.7.1.53	ko:K00880	ko00040,ko00053,map00040,map00053	-	R01901,R07127	RC00002,RC00017,RC00538	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
SX3_k127_4508014_14	742733.HMPREF9469_00094	1.051e-77	265.0	COG0235@1|root,COG0235@2|Bacteria,1V1TI@1239|Firmicutes,24FS0@186801|Clostridia,2207T@1506553|Lachnoclostridium	186801|Clostridia	G	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
SX3_k127_4508014_13	642227.HA49_12195	1.146e-82	284.0	COG3623@1|root,COG3623@2|Bacteria,1MWTD@1224|Proteobacteria,1RPT6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	3-epimerase	ulaE	GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0016857,GO:0019752,GO:0019852,GO:0034015,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0051186,GO:0071704	5.1.3.22	ko:K03079	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R03244	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	iEC55989_1330.EC55989_4754,iECSE_1348.ECSE_4495,iEcHS_1320.EcHS_A4441,iEcSMS35_1347.EcSMS35_4668,iYL1228.KPN_04590	AP_endonuc_2
SX3_k127_4508014_9	545695.TREAZ_0221	1.063e-99	339.0	COG0191@1|root,COG0191@2|Bacteria,2J9U8@203691|Spirochaetes	203691|Spirochaetes	G	Fructose-bisphosphate aldolase class-II	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
SX3_k127_4508014_18	1120746.CCNL01000008_gene733	5.244e-60	216.0	COG1028@1|root,COG1028@2|Bacteria,2NP4D@2323|unclassified Bacteria	2|Bacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SX3_k127_4508014_5	1499967.BAYZ01000012_gene2483	8.569e-109	371.0	COG1028@1|root,COG1028@2|Bacteria	1499967.BAYZ01000012_gene2483|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4508014_27	1499967.BAYZ01000012_gene2485	1.163e-23	103.0	COG4577@1|root,COG4577@2|Bacteria,2NRBW@2323|unclassified Bacteria	2|Bacteria	CQ	COGs COG4577 Carbon dioxide concentrating mechanism carboxysome shell protein	-	-	-	ko:K04027	-	-	-	-	ko00000	-	-	-	BMC
SX3_k127_4518966_0	744872.Spica_1067	4.929e-77	290.0	COG1196@1|root,COG3210@1|root,COG1196@2|Bacteria,COG3210@2|Bacteria,2J8QW@203691|Spirochaetes	203691|Spirochaetes	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4518966_1	1121396.KB893024_gene3911	4.097e-68	240.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,42N67@68525|delta/epsilon subdivisions,2WKPK@28221|Deltaproteobacteria,2MKTN@213118|Desulfobacterales	28221|Deltaproteobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
SX3_k127_4584286_7	926569.ANT_27050	1.04e-17	83.0	COG1695@1|root,COG1695@2|Bacteria,2G9N5@200795|Chloroflexi	200795|Chloroflexi	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR,Vir_act_alpha_C
SX3_k127_4584286_2	926569.ANT_27060	5.616e-98	325.0	COG1136@1|root,COG1136@2|Bacteria,2G69N@200795|Chloroflexi	200795|Chloroflexi	P	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_4584286_0	926569.ANT_27070	5.757e-225	726.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,2G6IW@200795|Chloroflexi	200795|Chloroflexi	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX3_k127_4584286_4	331113.SNE_A22970	1.918e-55	202.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	-	-	-	-	-	-	-	-	-	AAA_14,DUF4143
SX3_k127_4584286_6	331113.SNE_A22970	1.571e-18	95.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	-	-	-	-	-	-	-	-	-	AAA_14,DUF4143
SX3_k127_4584286_5	1121472.AQWN01000011_gene1205	3.053e-25	122.0	COG1879@1|root,COG1879@2|Bacteria,1TQ1B@1239|Firmicutes,247K8@186801|Clostridia,264HD@186807|Peptococcaceae	186801|Clostridia	G	Periplasmic binding protein-like domain	alsB	-	-	ko:K10439,ko:K10549	ko02010,ko02030,map02010,map02030	M00212,M00217	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.6	-	-	Peripla_BP_4
SX3_k127_4584286_3	1293054.HSACCH_00781	8.792e-56	209.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,249FA@186801|Clostridia,3WBBT@53433|Halanaerobiales	186801|Clostridia	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
SX3_k127_4584286_1	1007103.AFHW01000025_gene316	3.296e-123	409.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,4H9VK@91061|Bacilli,26SVT@186822|Paenibacillaceae	91061|Bacilli	G	import. Responsible for energy coupling to the transport system	rbsA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0006810,GO:0008144,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015146,GO:0015399,GO:0015405,GO:0015407,GO:0015591,GO:0015608,GO:0015611,GO:0015749,GO:0015750,GO:0015752,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034219,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043211,GO:0043492,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0097159,GO:0097367,GO:1901265,GO:1901363	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
SX3_k127_4651467_64	243275.TDE_1375	1.369e-27	114.0	COG0669@1|root,COG0669@2|Bacteria,2J7VS@203691|Spirochaetes	203691|Spirochaetes	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
SX3_k127_4651467_68	744872.Spica_1406	3.958e-22	96.0	COG0333@1|root,COG0333@2|Bacteria,2J8XR@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
SX3_k127_4651467_58	545695.TREAZ_3324	1.578e-35	136.0	COG0236@1|root,COG0236@2|Bacteria,2J8CN@203691|Spirochaetes	203691|Spirochaetes	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
SX3_k127_4651467_22	573413.Spirs_1889	1.446e-100	334.0	COG0571@1|root,COG0571@2|Bacteria,2J6UI@203691|Spirochaetes	203691|Spirochaetes	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
SX3_k127_4651467_13	1123274.KB899415_gene2499	5.26e-137	449.0	COG0617@1|root,COG1418@1|root,COG0617@2|Bacteria,COG1418@2|Bacteria,2J5ZC@203691|Spirochaetes	203691|Spirochaetes	H	PolyA polymerase	papS	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
SX3_k127_4651467_11	573413.Spirs_1891	2.032e-141	454.0	COG1344@1|root,COG1344@2|Bacteria,2J5TJ@203691|Spirochaetes	203691|Spirochaetes	N	Component of the core of the flagella	-	-	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
SX3_k127_4651467_54	545694.TREPR_2686	2.627e-45	174.0	COG1564@1|root,COG1564@2|Bacteria,2J7RD@203691|Spirochaetes	203691|Spirochaetes	H	Thiamin pyrophosphokinase, catalytic domain	-	-	2.7.6.2	ko:K00949	ko00730,ko01100,map00730,map01100	-	R00619	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TPK_B1_binding,TPK_catalytic
SX3_k127_4651467_44	1307761.L21SP2_1759	7.039e-58	205.0	COG0537@1|root,COG0537@2|Bacteria	2|Bacteria	FG	bis(5'-adenosyl)-triphosphatase activity	-	-	2.7.7.53	ko:K02503,ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000,ko04147	-	-	-	HIT,Helicase_C,Methyltransf_23,PLDc_2,ResIII
SX3_k127_4651467_61	665571.STHERM_c10720	2.933e-29	128.0	2FG0B@1|root,347X1@2|Bacteria,2J8HA@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4651467_47	926550.CLDAP_26890	6.133e-55	207.0	COG1454@1|root,COG1454@2|Bacteria,2G6IU@200795|Chloroflexi	200795|Chloroflexi	C	PFAM iron-containing alcohol dehydrogenase	-	-	1.1.1.1,1.1.99.24	ko:K00001,ko:K11173,ko:K13954	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
SX3_k127_4651467_72	106370.Francci3_2464	7.06e-20	96.0	COG4401@1|root,COG4401@2|Bacteria,2IHWT@201174|Actinobacteria,4ET13@85013|Frankiales	201174|Actinobacteria	E	Chorismate mutase type I	aroH	-	5.4.99.5	ko:K06208	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_1
SX3_k127_4651467_17	589865.DaAHT2_2094	1.578e-126	425.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2WITI@28221|Deltaproteobacteria,2MKJ1@213118|Desulfobacterales	28221|Deltaproteobacteria	G	synthase	glgA	GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0055114,GO:0071704,GO:1901576	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
SX3_k127_4651467_40	665571.STHERM_c10750	1.427e-66	238.0	COG0024@1|root,COG0024@2|Bacteria,2J5Z7@203691|Spirochaetes	203691|Spirochaetes	J	Methionine aminopeptidase	-	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
SX3_k127_4651467_20	573413.Spirs_3573	5.479e-113	397.0	COG0815@1|root,COG0815@2|Bacteria,2J60T@203691|Spirochaetes	203691|Spirochaetes	M	Transfers the fatty acyl group on membrane lipoproteins	cutE	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
SX3_k127_4651467_10	290397.Adeh_1758	2.105e-149	486.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YUJU@29|Myxococcales	28221|Deltaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	FHA,HTH_8,Response_reg,Sigma54_activat
SX3_k127_4651467_41	573370.DMR_14250	2.575e-61	239.0	COG4191@1|root,COG4936@1|root,COG4191@2|Bacteria,COG4936@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WM1A@28221|Deltaproteobacteria,2MAT9@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	SMART ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,PocR,Response_reg,SBP_bac_3,sCache_2
SX3_k127_4651467_51	1307761.L21SP2_1765	7.211e-51	184.0	COG0727@1|root,COG0727@2|Bacteria,2J85V@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Uncharacterised protein family (UPF0153)	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
SX3_k127_4651467_24	744872.Spica_1397	1.733e-99	333.0	COG1235@1|root,COG1235@2|Bacteria,2J5C5@203691|Spirochaetes	203691|Spirochaetes	S	Metallo-beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
SX3_k127_4651467_0	573413.Spirs_2081	0.0	1060.0	COG2885@1|root,COG2885@2|Bacteria,2J5KD@203691|Spirochaetes	203691|Spirochaetes	M	ompA family	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3,CHU_C,FlgD_ig,OmpA
SX3_k127_4651467_31	573413.Spirs_2080	4.64e-77	269.0	COG1559@1|root,COG1559@2|Bacteria,2J5V4@203691|Spirochaetes	203691|Spirochaetes	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
SX3_k127_4651467_15	573413.Spirs_2079	1.044e-135	452.0	COG0358@1|root,COG0358@2|Bacteria,2J5MX@203691|Spirochaetes	203691|Spirochaetes	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
SX3_k127_4651467_6	596324.TREVI0001_0055	3.909e-183	594.0	COG0568@1|root,COG0568@2|Bacteria,2J59P@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
SX3_k127_4651467_74	1123274.KB899421_gene1808	6.05e-18	86.0	COG1579@1|root,COG1579@2|Bacteria,2J6JN@203691|Spirochaetes	203691|Spirochaetes	S	Zn-ribbon protein, possibly nucleic acid-binding	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
SX3_k127_4651467_56	1123274.KB899421_gene1808	4.217e-44	166.0	COG1579@1|root,COG1579@2|Bacteria,2J6JN@203691|Spirochaetes	203691|Spirochaetes	S	Zn-ribbon protein, possibly nucleic acid-binding	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
SX3_k127_4651467_83	272624.lpg1742	4.591e-07	56.0	2E9J1@1|root,333RY@2|Bacteria,1NIX0@1224|Proteobacteria,1SGM0@1236|Gammaproteobacteria,1JFBK@118969|Legionellales	118969|Legionellales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4651467_34	1123274.KB899421_gene1806	3.108e-73	258.0	COG0457@1|root,COG0457@2|Bacteria,2J7G0@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_8
SX3_k127_4651467_7	1123274.KB899421_gene1805	4.752e-175	561.0	COG1077@1|root,COG1077@2|Bacteria,2J59M@203691|Spirochaetes	203691|Spirochaetes	D	cell shape determining protein, MreB Mrl	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
SX3_k127_4651467_43	545695.TREAZ_0490	1.499e-58	213.0	COG1792@1|root,COG1792@2|Bacteria,2J77U@203691|Spirochaetes	203691|Spirochaetes	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
SX3_k127_4651467_65	744872.Spica_1387	3.78e-27	117.0	COG2891@1|root,COG2891@2|Bacteria,2J89Q@203691|Spirochaetes	203691|Spirochaetes	M	Rod shape-determining protein (MreD)	mreD	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
SX3_k127_4651467_2	1123274.KB899421_gene1802	1.28e-202	647.0	COG0768@1|root,COG0768@2|Bacteria,2J595@203691|Spirochaetes	203691|Spirochaetes	M	Penicillin-binding Protein	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
SX3_k127_4651467_18	1123274.KB899421_gene1801	8.523e-126	419.0	COG0772@1|root,COG0772@2|Bacteria,2J62H@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the SEDS family. MrdB RodA subfamily	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
SX3_k127_4651467_4	573413.Spirs_2070	1.249e-189	640.0	COG1032@1|root,COG5011@1|root,COG1032@2|Bacteria,COG5011@2|Bacteria,2J5YW@203691|Spirochaetes	203691|Spirochaetes	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344,Radical_SAM
SX3_k127_4651467_32	545695.TREAZ_1383	1.339e-76	266.0	COG1694@1|root,COG3956@2|Bacteria,2J5HG@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM MazG family protein	mazG	-	3.6.1.9	ko:K02499,ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
SX3_k127_4651467_69	880073.Calab_1429	1.268e-21	109.0	COG1905@1|root,COG1905@2|Bacteria,2NPSB@2323|unclassified Bacteria	2|Bacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	1.12.1.4,1.6.5.3	ko:K00334,ko:K17999	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
SX3_k127_4651467_52	309799.DICTH_0414	5.817e-49	192.0	COG2344@1|root,COG2344@2|Bacteria	2|Bacteria	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
SX3_k127_4651467_21	573413.Spirs_1496	1.213e-109	368.0	2EY6N@1|root,33RFB@2|Bacteria,2J5R2@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Uncharacterised protein family UPF0164	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2,UPF0164
SX3_k127_4651467_75	665571.STHERM_c09520	1.492e-17	98.0	2EWYA@1|root,33Q9N@2|Bacteria,2J5N1@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4651467_1	665571.STHERM_c09530	4.205e-284	929.0	COG2208@1|root,COG2208@2|Bacteria,2J5MN@203691|Spirochaetes	203691|Spirochaetes	KT	Stage II sporulation protein E	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,SpoIIE
SX3_k127_4651467_29	479434.Sthe_0322	4.549e-79	279.0	COG0012@1|root,COG0012@2|Bacteria,2G5UY@200795|Chloroflexi,27XGT@189775|Thermomicrobia	189775|Thermomicrobia	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
SX3_k127_4651467_78	545694.TREPR_2525	2.219e-13	75.0	COG1933@1|root,COG1933@2|Bacteria	2|Bacteria	L	exodeoxyribonuclease I activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DUF5050,DZR,Guanylate_cyc,TPR_12
SX3_k127_4651467_62	906968.Trebr_0786	4.474e-29	134.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DUF1566,FGE-sulfatase,PD40,PEGA,Peptidase_S9,Pkinase,Ras,Sigma70_r2,TIR_2
SX3_k127_4651467_57	744872.Spica_0672	1.627e-42	168.0	2EQ1S@1|root,33HN8@2|Bacteria,2J7UJ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4651467_33	640081.Dsui_0653	4.408e-76	271.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,2VKNG@28216|Betaproteobacteria,2KUS1@206389|Rhodocyclales	206389|Rhodocyclales	J	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
SX3_k127_4651467_63	545695.TREAZ_0763	8.393e-28	117.0	COG1430@1|root,COG1430@2|Bacteria,2J80F@203691|Spirochaetes	203691|Spirochaetes	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
SX3_k127_4651467_16	573413.Spirs_1343	9.719e-129	433.0	COG1570@1|root,COG1570@2|Bacteria,2J5ED@203691|Spirochaetes	203691|Spirochaetes	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
SX3_k127_4651467_14	545695.TREAZ_1209	1.136e-136	451.0	COG0535@1|root,COG0535@2|Bacteria,2J6HP@203691|Spirochaetes	203691|Spirochaetes	S	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
SX3_k127_4651467_42	221027.JO40_11195	1.143e-60	222.0	COG1216@1|root,COG1216@2|Bacteria,2J6ET@203691|Spirochaetes	203691|Spirochaetes	S	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4651467_49	1123274.KB899412_gene1455	1.225e-52	193.0	COG1861@1|root,COG1861@2|Bacteria,2J58C@203691|Spirochaetes	203691|Spirochaetes	M	spore coat polysaccharide biosynthesis protein	spsF	-	-	ko:K07257	-	-	-	-	ko00000	-	-	-	CTP_transf_3,Methyltransf_23
SX3_k127_4651467_25	889378.Spiaf_1676	2.761e-99	351.0	COG2227@1|root,COG2227@2|Bacteria,2JBIU@203691|Spirochaetes	203691|Spirochaetes	H	Methyltransferase domain	ubiG	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
SX3_k127_4651467_12	744872.Spica_1633	3.984e-141	481.0	COG1181@1|root,COG1181@2|Bacteria,2J5KK@203691|Spirochaetes	203691|Spirochaetes	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3,ATP-grasp_4
SX3_k127_4651467_28	906968.Trebr_1836	2.148e-79	278.0	COG0860@1|root,COG0860@2|Bacteria,2J5PE@203691|Spirochaetes	203691|Spirochaetes	M	N-acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,Cu_amine_oxidN1
SX3_k127_4651467_19	1480694.DC28_00545	1.514e-120	396.0	2BFJ7@1|root,329D7@2|Bacteria,2J651@203691|Spirochaetes	203691|Spirochaetes	N	flagellar filament outer layer protein	flaA	-	-	-	-	-	-	-	-	-	-	-	FlaA
SX3_k127_4651467_9	573413.Spirs_2850	1.079e-155	518.0	COG0243@1|root,COG0243@2|Bacteria,2J9ZG@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.3	ko:K07306	ko00920,map00920	-	R09501	RC02555	ko00000,ko00001,ko01000,ko02000	5.A.3.3	-	-	Molybdopterin,Molydop_binding,Nitrate_red_del
SX3_k127_4651467_60	331678.Cphamn1_2378	1.788e-31	133.0	COG0746@1|root,COG1763@1|root,COG0746@2|Bacteria,COG1763@2|Bacteria,1FEC3@1090|Chlorobi	1090|Chlorobi	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	MobB,NTP_transf_3
SX3_k127_4651467_46	744872.Spica_0957	4.31e-55	209.0	2F39Z@1|root,33W49@2|Bacteria,2J8PJ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4651467_81	637389.Acaty_c1894	2.121e-07	61.0	COG0745@1|root,COG0745@2|Bacteria,1RDNP@1224|Proteobacteria,1S47I@1236|Gammaproteobacteria,2NDSX@225057|Acidithiobacillales	225057|Acidithiobacillales	KT	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
SX3_k127_4651467_84	877418.ATWV01000001_gene1641	7.982e-05	55.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,2J5F4@203691|Spirochaetes	203691|Spirochaetes	NT	chemotaxis protein	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
SX3_k127_4651467_82	469381.Dpep_0270	4.001e-07	63.0	COG0643@1|root,COG0643@2|Bacteria,3T9SQ@508458|Synergistetes	508458|Synergistetes	T	Signal transducing histidine kinase homodimeric	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
SX3_k127_4651467_67	1123274.KB899407_gene218	7.823e-25	108.0	COG5341@1|root,COG5341@2|Bacteria,2J8UX@203691|Spirochaetes	203691|Spirochaetes	S	NusG domain II	-	-	-	-	-	-	-	-	-	-	-	-	NusG_II
SX3_k127_4651467_48	545694.TREPR_0972	3.067e-53	197.0	COG4769@1|root,COG4769@2|Bacteria,2J81I@203691|Spirochaetes	203691|Spirochaetes	S	heptaprenyl diphosphate synthase component I	-	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	Hpre_diP_synt_I
SX3_k127_4651467_73	1123274.KB899413_gene814	4.499e-18	96.0	2DEN8@1|root,2ZNJD@2|Bacteria,2J8NJ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4651467_50	926561.KB900622_gene616	1.598e-52	197.0	COG1575@1|root,COG1575@2|Bacteria,1TSZV@1239|Firmicutes,24DJF@186801|Clostridia,3WBRF@53433|Halanaerobiales	186801|Clostridia	H	UbiA prenyltransferase family	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	iHN637.CLJU_RS19835	UbiA
SX3_k127_4651467_37	1480694.DC28_10720	9.888e-70	248.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
SX3_k127_4651467_38	1121456.ATVA01000013_gene853	1.129e-69	244.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,42MQ5@68525|delta/epsilon subdivisions,2WK19@28221|Deltaproteobacteria,2MH0B@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
SX3_k127_4651467_39	697281.Mahau_2233	1.058e-66	235.0	COG0600@1|root,COG0600@2|Bacteria,1V3NA@1239|Firmicutes,24G03@186801|Clostridia,42GGA@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
SX3_k127_4651467_26	857293.CAAU_0346	3.888e-94	321.0	COG1477@1|root,COG1477@2|Bacteria,1TR9C@1239|Firmicutes,248KJ@186801|Clostridia,36DZZ@31979|Clostridiaceae	186801|Clostridia	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	apbE	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
SX3_k127_4651467_5	665571.STHERM_c19840	2.98e-185	602.0	COG1252@1|root,COG1252@2|Bacteria,2J79T@203691|Spirochaetes	203691|Spirochaetes	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
SX3_k127_4651467_35	545697.HMPREF0216_03044	3.286e-72	254.0	COG0142@1|root,COG0142@2|Bacteria,1TR0U@1239|Firmicutes,24AW3@186801|Clostridia,36DFW@31979|Clostridiaceae	186801|Clostridia	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
SX3_k127_4651467_36	296591.Bpro_1381	6.044e-72	244.0	COG5649@1|root,COG5649@2|Bacteria,1RGY3@1224|Proteobacteria,2VRM6@28216|Betaproteobacteria,4AEDP@80864|Comamonadaceae	28216|Betaproteobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
SX3_k127_4651467_76	889378.Spiaf_1155	4.017e-17	85.0	COG2608@1|root,COG2608@2|Bacteria	2|Bacteria	P	mercury ion transmembrane transporter activity	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K07213,ko:K08364,ko:K17686	ko01524,ko04016,ko04978,map01524,map04016,map04978	-	R00086	RC00002	ko00000,ko00001,ko01000,ko02000	1.A.72.1,3.A.3.5	-	-	HMA,MerT
SX3_k127_4651467_3	335543.Sfum_2726	8.926e-195	622.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,42MZN@68525|delta/epsilon subdivisions,2WJGK@28221|Deltaproteobacteria,2MQ6X@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
SX3_k127_4651467_66	335543.Sfum_2728	6.626e-25	115.0	COG1371@1|root,COG1371@2|Bacteria,1NCP6@1224|Proteobacteria,42VQE@68525|delta/epsilon subdivisions,2WS6C@28221|Deltaproteobacteria,2MQPH@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Archease protein family (MTH1598/TM1083)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
SX3_k127_4651467_8	552811.Dehly_0563	7.886e-173	551.0	COG0426@1|root,COG0426@2|Bacteria,2G9HN@200795|Chloroflexi	200795|Chloroflexi	C	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4651467_23	1125863.JAFN01000001_gene87	9.443e-100	340.0	COG2461@1|root,COG2461@2|Bacteria,1R5J5@1224|Proteobacteria,42QAZ@68525|delta/epsilon subdivisions,2WQTR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Hemerythrin HHE cation binding domain	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF1858,DUF438,Hemerythrin,PAS_10
SX3_k127_4651467_30	158190.SpiGrapes_1174	9.271e-78	279.0	COG1122@1|root,COG1122@2|Bacteria,2J5SA@203691|Spirochaetes	203691|Spirochaetes	P	ABC transporter	-	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
SX3_k127_4651467_59	760011.Spico_1326	2.033e-34	145.0	COG0619@1|root,COG0619@2|Bacteria,2J7RZ@203691|Spirochaetes	203691|Spirochaetes	P	cobalt transport protein	-	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
SX3_k127_4651467_55	158190.SpiGrapes_1172	1.561e-44	168.0	COG4720@1|root,COG4720@2|Bacteria	2|Bacteria	P	Psort location CytoplasmicMembrane, score	XK27_01265	-	-	ko:K16923,ko:K16924	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.28,3.A.1.29	-	-	ECF-ribofla_trS
SX3_k127_4651467_45	1307761.L21SP2_1895	6.276e-57	214.0	COG0325@1|root,COG0325@2|Bacteria,2J71S@203691|Spirochaetes	203691|Spirochaetes	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
SX3_k127_4651467_77	744872.Spica_1584	1.734e-16	90.0	290S3@1|root,34CB1@2|Bacteria,2J8EJ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4651467_27	545694.TREPR_3488	6.042e-89	308.0	COG0564@1|root,COG0564@2|Bacteria,2J63B@203691|Spirochaetes	203691|Spirochaetes	J	Responsible for synthesis of pseudouridine from uracil	rluD_1	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
SX3_k127_4651467_53	665571.STHERM_c17070	3.412e-48	183.0	COG0491@1|root,COG0491@2|Bacteria,2J7B4@203691|Spirochaetes	203691|Spirochaetes	S	Metallo-beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SX3_k127_4651467_70	665571.STHERM_c17050	1.618e-21	103.0	COG1357@1|root,COG1357@2|Bacteria,2J652@203691|Spirochaetes	203691|Spirochaetes	S	Pentapeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide,Pentapeptide_4
SX3_k127_4651467_71	1124982.MSI_22750	9.335e-21	94.0	2EH48@1|root,33AW7@2|Bacteria,2J921@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4656788_14	1480694.DC28_00800	1.079e-85	292.0	COG0052@1|root,COG0052@2|Bacteria,2J5GZ@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
SX3_k127_4656788_19	744872.Spica_1414	1.394e-42	163.0	COG0424@1|root,COG0424@2|Bacteria,2J7EA@203691|Spirochaetes	203691|Spirochaetes	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
SX3_k127_4656788_23	68570.DC74_6664	4.098e-25	121.0	COG3379@1|root,COG3379@2|Bacteria,2IBWQ@201174|Actinobacteria	201174|Actinobacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
SX3_k127_4656788_0	1499967.BAYZ01000179_gene4626	4.062e-292	909.0	COG2414@1|root,COG2414@2|Bacteria	2|Bacteria	C	aldehyde ferredoxin oxidoreductase activity	-	-	1.2.7.5,1.2.7.6	ko:K03738,ko:K11389	ko00010,ko00030,ko01100,ko01120,ko01200,ko01230,map00010,map00030,map01100,map01120,map01200,map01230	M00001,M00002,M00309	R07159,R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
SX3_k127_4656788_16	744872.Spica_0292	1.313e-74	267.0	COG5522@1|root,COG5522@2|Bacteria	2|Bacteria	S	Integral membrane protein (intg_mem_TP0381)	ywaF	-	-	-	-	-	-	-	-	-	-	-	Intg_mem_TP0381
SX3_k127_4656788_10	1499967.BAYZ01000142_gene6157	4.753e-113	372.0	COG1177@1|root,COG1177@2|Bacteria,2NPND@2323|unclassified Bacteria	2|Bacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K11070	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
SX3_k127_4656788_5	1499967.BAYZ01000142_gene6158	7.839e-131	424.0	COG1176@1|root,COG1176@2|Bacteria,2NPH4@2323|unclassified Bacteria	2|Bacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K11070,ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
SX3_k127_4656788_2	1499967.BAYZ01000142_gene6159	2.671e-159	509.0	COG3842@1|root,COG3842@2|Bacteria,2NNPE@2323|unclassified Bacteria	2|Bacteria	E	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008144,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015101,GO:0015203,GO:0015399,GO:0015405,GO:0015417,GO:0015595,GO:0015606,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0015848,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0097159,GO:0097367,GO:0098533,GO:0098655,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1902047,GO:1902494,GO:1902495,GO:1903711,GO:1904949,GO:1990351	3.6.3.30,3.6.3.31,3.6.3.55	ko:K02010,ko:K06857,ko:K11072	ko02010,map02010	M00186,M00190,M00299	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10,3.A.1.11.1,3.A.1.6.2,3.A.1.6.4	-	iB21_1397.B21_01132,iECBD_1354.ECBD_2473,iECB_1328.ECB_01124,iECD_1391.ECD_01124,iECO111_1330.ECO111_1474,iECO26_1355.ECO26_1643,iEcHS_1320.EcHS_A1246,iEcolC_1368.EcolC_2477,iSB619.SA_RS05380,iSBO_1134.SBO_1915,iSSON_1240.SSON_1144,iSbBS512_1146.SbBS512_E1304,iUMNK88_1353.UMNK88_1456	ABC_tran,TOBE_2
SX3_k127_4656788_3	1499967.BAYZ01000142_gene6160	1.089e-149	491.0	COG0687@1|root,COG0687@2|Bacteria	2|Bacteria	E	Required for the activity of the bacterial periplasmic transport system of putrescine	-	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_8
SX3_k127_4656788_6	886293.Sinac_1525	1.669e-125	411.0	COG2115@1|root,COG2115@2|Bacteria	2|Bacteria	G	xylose isomerase activity	-	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
SX3_k127_4656788_13	1499967.BAYZ01000017_gene6250	4.568e-91	317.0	COG2120@1|root,COG2120@2|Bacteria,2NPAV@2323|unclassified Bacteria	2|Bacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
SX3_k127_4656788_4	665571.STHERM_c19850	4.341e-144	470.0	COG3775@1|root,COG3775@2|Bacteria,2J9HY@203691|Spirochaetes	203691|Spirochaetes	G	PTS system sugar-specific permease component	-	-	-	ko:K02775	ko00052,ko01100,ko02060,map00052,map01100,map02060	M00279	R05570	RC00017,RC03206	ko00000,ko00001,ko00002,ko02000	4.A.5.1	-	-	EIIC-GAT
SX3_k127_4656788_18	1033743.CAES01000001_gene1711	5.169e-44	171.0	COG2120@1|root,COG2120@2|Bacteria,1TUFR@1239|Firmicutes,4I855@91061|Bacilli,26YXG@186822|Paenibacillaceae	91061|Bacilli	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
SX3_k127_4656788_8	1499967.BAYZ01000143_gene6119	2.448e-116	381.0	COG0395@1|root,COG0395@2|Bacteria	1499967.BAYZ01000143_gene6119|-	P	glycerophosphodiester transmembrane transport	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4656788_12	1499967.BAYZ01000143_gene6118	8.568e-102	339.0	COG1175@1|root,COG1175@2|Bacteria,2NPDA@2323|unclassified Bacteria	2|Bacteria	G	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K15771	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
SX3_k127_4656788_9	1499967.BAYZ01000142_gene6164	6.209e-116	388.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1
SX3_k127_4656788_11	1499967.BAYZ01000142_gene6163	1.253e-110	371.0	COG1402@1|root,COG1402@2|Bacteria	2|Bacteria	I	creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
SX3_k127_4656788_17	595460.RRSWK_05035	6.464e-45	173.0	COG3622@1|root,COG3622@2|Bacteria,2J06A@203682|Planctomycetes	203682|Planctomycetes	G	Xylose isomerase-like TIM barrel	-	-	5.3.1.22	ko:K01816	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
SX3_k127_4656788_7	525904.Tter_2212	4.878e-117	390.0	COG0399@1|root,COG0399@2|Bacteria,2NQH7@2323|unclassified Bacteria	2|Bacteria	E	Cys/Met metabolism PLP-dependent enzyme	stsA	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0016051,GO:0043170,GO:0044238,GO:0071704,GO:1901576	2.6.1.109	ko:K19715	-	-	R11395	RC00160	ko00000,ko01000,ko01005	-	-	-	DegT_DnrJ_EryC1
SX3_k127_4656788_15	1499967.BAYZ01000142_gene6161	9.401e-82	289.0	COG1940@1|root,COG1940@2|Bacteria	2|Bacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	ROK
SX3_k127_4656788_20	1232443.BAIA02000106_gene3141	2.043e-40	161.0	COG1402@1|root,COG1402@2|Bacteria,1VG9Z@1239|Firmicutes,24RVY@186801|Clostridia	186801|Clostridia	S	Creatinine amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Creatininase
SX3_k127_4656788_22	926569.ANT_11020	7.13e-27	119.0	COG1846@1|root,COG1940@1|root,COG1846@2|Bacteria,COG1940@2|Bacteria,2G6IH@200795|Chloroflexi	200795|Chloroflexi	GK	PFAM ROK family protein	-	-	-	-	-	-	-	-	-	-	-	-	ROK
SX3_k127_4658519_0	1499967.BAYZ01000131_gene358	2.191e-154	500.0	COG1653@1|root,COG2188@1|root,COG1653@2|Bacteria,COG2188@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K02027,ko:K03710	-	M00207	-	-	ko00000,ko00002,ko02000,ko03000	3.A.1.1	-	-	GntR,SBP_bac_8,UTRA
SX3_k127_4658519_1	1195236.CTER_4148	7.53e-19	101.0	COG1879@1|root,COG1879@2|Bacteria,1UZZW@1239|Firmicutes,24BEX@186801|Clostridia,3WQK9@541000|Ruminococcaceae	186801|Clostridia	G	ABC-type sugar transport system, periplasmic component	-	-	-	ko:K10537	ko02010,map02010	M00213	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.2	-	-	Peripla_BP_4
SX3_k127_4672149_6	489825.LYNGBM3L_44820	5.394e-128	422.0	COG0498@1|root,COG0498@2|Bacteria,1GBSB@1117|Cyanobacteria,1HF21@1150|Oscillatoriales	1117|Cyanobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
SX3_k127_4672149_14	997296.PB1_07702	3.113e-10	69.0	COG1309@1|root,COG1309@2|Bacteria,1V2EH@1239|Firmicutes,4HJ4X@91061|Bacilli,1ZGU3@1386|Bacillus	91061|Bacilli	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
SX3_k127_4672149_5	706587.Desti_1123	1.059e-128	425.0	COG2855@1|root,COG2855@2|Bacteria,1MVPE@1224|Proteobacteria,42NT6@68525|delta/epsilon subdivisions,2WJ9R@28221|Deltaproteobacteria,2MR46@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Conserved hypothetical protein 698	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
SX3_k127_4672149_0	573413.Spirs_1386	7.4e-323	1018.0	COG0493@1|root,COG1145@1|root,COG0493@2|Bacteria,COG1145@2|Bacteria,2J6YZ@203691|Spirochaetes	203691|Spirochaetes	C	Selenate reductase YgfK	gltD	-	1.97.1.9	ko:K12527	ko00450,map00450	-	R07229	RC02420	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2,Pyr_redox_3
SX3_k127_4672149_3	1115512.EH105704_02_04220	2.108e-160	517.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1TFX9@1236|Gammaproteobacteria,3XM8H@561|Escherichia	1236|Gammaproteobacteria	F	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	ssnA	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
SX3_k127_4672149_7	545694.TREPR_2780	1.313e-87	316.0	COG0457@1|root,COG1652@1|root,COG0457@2|Bacteria,COG1652@2|Bacteria,2J7YH@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4672149_10	1195236.CTER_1364	2.515e-54	218.0	COG3292@1|root,COG3325@1|root,COG3469@1|root,COG3292@2|Bacteria,COG3325@2|Bacteria,COG3469@2|Bacteria	2|Bacteria	G	chitinase activity	wapA	GO:0003674,GO:0003824,GO:0004553,GO:0004568,GO:0005575,GO:0005576,GO:0006022,GO:0006026,GO:0006030,GO:0006032,GO:0006040,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016798,GO:0017144,GO:0042737,GO:0043170,GO:0044237,GO:0044248,GO:0046348,GO:0071704,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	CHB_HEX_C_1,CarboxypepD_reg,Glyco_hydro_18,SLH
SX3_k127_4672149_8	1408473.JHXO01000015_gene1925	2.379e-73	279.0	COG2247@1|root,COG2911@1|root,COG4733@1|root,COG2247@2|Bacteria,COG2911@2|Bacteria,COG4733@2|Bacteria,4PHY6@976|Bacteroidetes,2FTM3@200643|Bacteroidia	976|Bacteroidetes	M	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4672149_1	1121405.dsmv_0691	3.796e-194	619.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions,2WIRQ@28221|Deltaproteobacteria,2MN1S@213118|Desulfobacterales	68525|delta/epsilon subdivisions	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
SX3_k127_4672149_12	1382359.JIAL01000001_gene361	5.2e-36	150.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
SX3_k127_4672149_9	180332.JTGN01000016_gene988	5.945e-55	207.0	COG0407@1|root,COG0407@2|Bacteria,1VSZ6@1239|Firmicutes,24F3A@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_4672149_4	573413.Spirs_2245	8.453e-150	495.0	COG1022@1|root,COG1022@2|Bacteria,2J6MK@203691|Spirochaetes	203691|Spirochaetes	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
SX3_k127_4672149_11	1210884.HG799468_gene13742	7.331e-39	162.0	COG3356@1|root,COG3356@2|Bacteria,2IXDY@203682|Planctomycetes	203682|Planctomycetes	G	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
SX3_k127_4672149_2	1499967.BAYZ01000177_gene5701	2.472e-170	544.0	COG2407@1|root,COG2407@2|Bacteria,2NRQW@2323|unclassified Bacteria	2|Bacteria	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4704833_13	1480694.DC28_12400	1.11e-46	169.0	COG1136@1|root,COG1136@2|Bacteria,2J7FN@203691|Spirochaetes	203691|Spirochaetes	V	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003,ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_4704833_4	1480694.DC28_12405	1.987e-115	384.0	COG4591@1|root,COG4591@2|Bacteria,2J7QZ@203691|Spirochaetes	203691|Spirochaetes	M	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX3_k127_4704833_6	1480694.DC28_12410	3.631e-95	336.0	COG4591@1|root,COG4591@2|Bacteria,2JA02@203691|Spirochaetes	203691|Spirochaetes	M	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX3_k127_4704833_11	1480694.DC28_12415	9.378e-69	241.0	COG2834@1|root,COG2834@2|Bacteria,2J7Z0@203691|Spirochaetes	203691|Spirochaetes	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
SX3_k127_4704833_12	1307761.L21SP2_2222	4.183e-49	194.0	2EG9W@1|root,33A1P@2|Bacteria,2J9F9@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4704833_9	1173028.ANKO01000116_gene5719	3.124e-81	276.0	COG2114@1|root,COG2114@2|Bacteria,1G6D6@1117|Cyanobacteria,1HB2S@1150|Oscillatoriales	1117|Cyanobacteria	T	COGs COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain)	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
SX3_k127_4704833_25	1047013.AQSP01000112_gene386	3.809e-09	62.0	COG2002@1|root,COG2002@2|Bacteria,2NS2K@2323|unclassified Bacteria	2|Bacteria	K	toxin-antitoxin pair type II binding	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
SX3_k127_4704833_15	176299.Atu3013	9.648e-42	157.0	COG1487@1|root,COG1487@2|Bacteria,1RJ2J@1224|Proteobacteria,2UA97@28211|Alphaproteobacteria,4BEJ5@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
SX3_k127_4704833_17	1499967.BAYZ01000091_gene3427	5.154e-39	169.0	COG4249@1|root,COG4249@2|Bacteria,2NRSS@2323|unclassified Bacteria	2|Bacteria	S	Peptidase C13 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,SLH,WD40
SX3_k127_4704833_7	909663.KI867150_gene2881	2.876e-88	316.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42QJF@68525|delta/epsilon subdivisions,2WJ9D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,Response_reg
SX3_k127_4704833_22	945713.IALB_0533	2.663e-19	101.0	COG0745@1|root,COG0745@2|Bacteria	945713.IALB_0533|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4704833_3	880073.Calab_1426	2.459e-160	527.0	COG4191@1|root,COG4624@1|root,COG4191@2|Bacteria,COG4624@2|Bacteria,2NP4X@2323|unclassified Bacteria	2|Bacteria	C	Putative Fe-S cluster	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	FeS,Fe_hyd_lg_C,Fer4,Fer4_10,HAMP,HATPase_c,HTH_8,HisKA,PAS_9,Sigma54_activat
SX3_k127_4704833_1	945713.IALB_0531	1.041e-211	672.0	COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria	2|Bacteria	C	iron-sulfur cluster assembly	-	-	1.12.1.3,1.6.5.3	ko:K00336,ko:K18332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_20,Fer4_6,Fer4_9,NADH-G_4Fe-4S_3,Pyr_redox_2
SX3_k127_4704833_0	1191523.MROS_2481	1.212e-231	734.0	COG1894@1|root,COG3411@1|root,COG1894@2|Bacteria,COG3411@2|Bacteria	2|Bacteria	C	Ferredoxin	hoxF	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K05587,ko:K17992,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
SX3_k127_4704833_16	880073.Calab_1429	1.484e-40	155.0	COG1905@1|root,COG1905@2|Bacteria,2NPSB@2323|unclassified Bacteria	2|Bacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	1.12.1.4,1.6.5.3	ko:K00334,ko:K17999	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
SX3_k127_4704833_8	402777.KB235903_gene774	1.433e-86	311.0	COG0642@1|root,COG0745@1|root,COG2114@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M4@1150|Oscillatoriales	1117|Cyanobacteria	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain	-	-	-	ko:K19694	-	-	-	-	ko00000,ko01001,ko02022	-	-	-	Guanylate_cyc,HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg,dCache_1
SX3_k127_4704833_19	682795.AciX8_2388	1.38e-31	132.0	COG1011@1|root,COG1011@2|Bacteria,3Y56D@57723|Acidobacteria,2JJQ6@204432|Acidobacteriia	204432|Acidobacteriia	S	HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
SX3_k127_4704833_24	1382356.JQMP01000003_gene2473	2.736e-15	85.0	2ADJ7@1|root,3139N@2|Bacteria,2GA53@200795|Chloroflexi,27Z9V@189775|Thermomicrobia	189775|Thermomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4704833_26	1382356.JQMP01000003_gene2473	3.227e-08	61.0	2ADJ7@1|root,3139N@2|Bacteria,2GA53@200795|Chloroflexi,27Z9V@189775|Thermomicrobia	189775|Thermomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4704833_10	1267533.KB906737_gene1888	2.5e-69	250.0	COG2222@1|root,COG2222@2|Bacteria,3Y3W8@57723|Acidobacteria,2JHQD@204432|Acidobacteriia	204432|Acidobacteriia	G	PFAM Sugar isomerase (SIS)	-	-	-	ko:K02082	-	-	-	-	ko00000,ko01000	-	-	-	SIS
SX3_k127_4704833_18	1463820.JOGW01000008_gene1735	2.824e-32	141.0	COG0524@1|root,COG0524@2|Bacteria,2GKQP@201174|Actinobacteria	201174|Actinobacteria	G	Carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
SX3_k127_4704833_2	468059.AUHA01000002_gene630	6.679e-186	600.0	COG1132@1|root,COG1132@2|Bacteria,4NEBS@976|Bacteroidetes,1IPPE@117747|Sphingobacteriia	976|Bacteroidetes	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SX3_k127_4704833_20	492774.JQMB01000014_gene1402	1.906e-31	134.0	COG0412@1|root,COG0412@2|Bacteria,1RG6A@1224|Proteobacteria,2U7V6@28211|Alphaproteobacteria,4BB2T@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	Protein involved in hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	DLH
SX3_k127_4704833_23	1125863.JAFN01000001_gene1183	9.873e-16	82.0	COG0745@1|root,COG0745@2|Bacteria,1N9SP@1224|Proteobacteria,43ECG@68525|delta/epsilon subdivisions,2X7Z1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
SX3_k127_4704833_5	1195236.CTER_3527	1.728e-110	373.0	COG1453@1|root,COG1453@2|Bacteria,1TSTA@1239|Firmicutes,249IP@186801|Clostridia,3WIUA@541000|Ruminococcaceae	186801|Clostridia	S	aldo keto reductase family	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
SX3_k127_4704833_14	1242864.D187_004642	1.506e-45	169.0	COG0454@1|root,COG0456@2|Bacteria,1Q1ZZ@1224|Proteobacteria,42USA@68525|delta/epsilon subdivisions,2WQ2Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SX3_k127_4704833_21	1499967.BAYZ01000164_gene6663	9.61e-30	123.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_4778277_10	177439.DP1269	1.573e-27	114.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,42TE0@68525|delta/epsilon subdivisions,2WPEP@28221|Deltaproteobacteria,2MKDG@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
SX3_k127_4778277_3	177439.DP1270	1.338e-71	255.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,42NMG@68525|delta/epsilon subdivisions,2WJIS@28221|Deltaproteobacteria,2MIA1@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	livG	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
SX3_k127_4778277_2	1121403.AUCV01000001_gene872	1.008e-86	294.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42M5A@68525|delta/epsilon subdivisions,2WK03@28221|Deltaproteobacteria,2MJNZ@213118|Desulfobacterales	28221|Deltaproteobacteria	E	ABC transporter	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
SX3_k127_4778277_0	429009.Adeg_0166	1.143e-153	498.0	COG1541@1|root,COG1541@2|Bacteria,1TQA1@1239|Firmicutes,248G9@186801|Clostridia,42FTU@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
SX3_k127_4778277_8	1254432.SCE1572_41585	2.001e-52	196.0	COG0266@1|root,COG0266@2|Bacteria,1MVHK@1224|Proteobacteria,43791@68525|delta/epsilon subdivisions,2X9X0@28221|Deltaproteobacteria,2YZTI@29|Myxococcales	28221|Deltaproteobacteria	L	Belongs to the FPG family	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
SX3_k127_4778277_5	1382306.JNIM01000001_gene3630	1.106e-70	252.0	COG3752@1|root,COG3752@2|Bacteria,2G9CW@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF1295)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
SX3_k127_4778277_4	889378.Spiaf_2749	3.241e-71	253.0	2F5GM@1|root,33Y28@2|Bacteria,2J87Y@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4778277_7	744872.Spica_1047	6.41e-55	208.0	2DM20@1|root,31DN4@2|Bacteria,2J5AS@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4778277_6	377629.TERTU_3506	1.026e-69	240.0	2AQX7@1|root,2ZYYX@2|Bacteria,1Q59E@1224|Proteobacteria,1SY7J@1236|Gammaproteobacteria,2PQIE@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4778277_11	935836.JAEL01000048_gene3635	2.583e-26	116.0	COG1309@1|root,COG1309@2|Bacteria,1VDE5@1239|Firmicutes,4HMH3@91061|Bacilli,1ZEI0@1386|Bacillus	91061|Bacilli	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
SX3_k127_4778277_12	1094980.Mpsy_0955	1.066e-14	76.0	COG0599@1|root,arCOG02151@2157|Archaea,2Y0W0@28890|Euryarchaeota,2NB47@224756|Methanomicrobia	224756|Methanomicrobia	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
SX3_k127_4778277_13	1038859.AXAU01000011_gene2414	3.911e-10	67.0	COG3070@1|root,COG3070@2|Bacteria,1P6Z6@1224|Proteobacteria	1224|Proteobacteria	K	TfoX N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	TfoX_N
SX3_k127_4778277_1	697281.Mahau_0032	1.281e-105	354.0	COG0407@1|root,COG0407@2|Bacteria,1V5KX@1239|Firmicutes,24IAR@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_4778277_9	1499967.BAYZ01000074_gene2080	4.946e-50	185.0	COG1853@1|root,COG1853@2|Bacteria,2NQXP@2323|unclassified Bacteria	2|Bacteria	S	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family	actI	-	1.5.1.36	ko:K00484	ko00350,ko00740,ko01100,ko01120,ko01220,map00350,map00740,map01100,map01120,map01220	-	R02698,R03299,R05705,R09748,R09750	RC00046,RC00126	ko00000,ko00001,ko01000	-	-	-	Flavin_Reduct
SX3_k127_4816667_10	1408418.JNJH01000011_gene3691	0.0002677	46.0	COG1879@1|root,COG1879@2|Bacteria,1MV17@1224|Proteobacteria,2U8PP@28211|Alphaproteobacteria,2JWTK@204441|Rhodospirillales	204441|Rhodospirillales	G	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_4
SX3_k127_4816667_5	1121127.JAFA01000007_gene5325	7.569e-98	333.0	COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,2WAQR@28216|Betaproteobacteria,1K3VE@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
SX3_k127_4816667_6	1408418.JNJH01000011_gene3689	1.98e-91	308.0	COG1129@1|root,COG1129@2|Bacteria,1MW4I@1224|Proteobacteria,2VFEX@28211|Alphaproteobacteria,2JWD2@204441|Rhodospirillales	204441|Rhodospirillales	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
SX3_k127_4816667_7	717605.Theco_0991	4.153e-50	193.0	COG1609@1|root,COG1609@2|Bacteria,1TP9Q@1239|Firmicutes,4HARD@91061|Bacilli,26RWZ@186822|Paenibacillaceae	91061|Bacilli	K	GntR family transcriptional regulator	araR	-	-	ko:K02103	-	-	-	-	ko00000,ko03000	-	-	-	GntR,Peripla_BP_3
SX3_k127_4816667_8	635013.TherJR_0736	6.766e-45	166.0	COG4747@1|root,COG4747@2|Bacteria,1V7U2@1239|Firmicutes,24JE5@186801|Clostridia,2629K@186807|Peptococcaceae	186801|Clostridia	S	PFAM Amino acid-binding ACT	-	-	-	-	-	-	-	-	-	-	-	-	ACT
SX3_k127_4816667_2	335543.Sfum_1683	1.962e-179	573.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42NKD@68525|delta/epsilon subdivisions,2WIWV@28221|Deltaproteobacteria,2MR0M@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK-2	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1825	AMP-binding,AMP-binding_C_2
SX3_k127_4816667_9	1499967.BAYZ01000078_gene986	8.119e-37	143.0	COG4747@1|root,COG4747@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ACT
SX3_k127_4816667_3	273121.WS0932	5.633e-171	550.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42PY9@68525|delta/epsilon subdivisions,2YQSR@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	H	coenzyme F390	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	-
SX3_k127_4816667_4	744872.Spica_0293	6.121e-122	407.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	ndh	-	1.6.99.3	ko:K03885,ko:K10716	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Abhydrolase_6,Ion_trans,Pyr_redox_2,cNMP_binding
SX3_k127_4816667_1	1499967.BAYZ01000032_gene1137	2.059e-193	616.0	COG1070@1|root,COG1070@2|Bacteria	2|Bacteria	G	xylulokinase activity	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
SX3_k127_4816667_0	1499967.BAYZ01000032_gene1138	2.691e-217	702.0	COG2407@1|root,COG2407@2|Bacteria	2|Bacteria	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	Fucose_iso_C
SX3_k127_4832898_4	1121346.KB899826_gene420	3.767e-22	109.0	COG1609@1|root,COG1609@2|Bacteria,1TP9Q@1239|Firmicutes,4HARD@91061|Bacilli,26RWZ@186822|Paenibacillaceae	91061|Bacilli	K	GntR family transcriptional regulator	araR	-	-	ko:K02103	-	-	-	-	ko00000,ko03000	-	-	-	GntR,Peripla_BP_3
SX3_k127_4832898_5	1500893.JQNB01000001_gene2635	1.141e-18	96.0	COG2159@1|root,COG2159@2|Bacteria,1MUUR@1224|Proteobacteria	1224|Proteobacteria	K	amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
SX3_k127_4832898_1	573413.Spirs_1237	3.776e-74	260.0	COG2017@1|root,COG2017@2|Bacteria,2JAQS@203691|Spirochaetes	203691|Spirochaetes	G	Aldose 1-epimerase	-	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
SX3_k127_4832898_2	869213.JCM21142_31337	5.053e-74	263.0	COG0153@1|root,COG0153@2|Bacteria,4NE0C@976|Bacteroidetes,47JY8@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the GHMP kinase family. GalK subfamily	galK	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
SX3_k127_4832898_0	370438.PTH_0393	1.339e-81	286.0	COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,24862@186801|Clostridia,261AB@186807|Peptococcaceae	186801|Clostridia	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
SX3_k127_4832898_3	335543.Sfum_1538	9.672e-30	130.0	COG1091@1|root,COG1091@2|Bacteria,1MUXM@1224|Proteobacteria,42MGE@68525|delta/epsilon subdivisions,2WJC2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
SX3_k127_4957326_1	1033810.HLPCO_002491	1.581e-142	464.0	COG0156@1|root,COG0156@2|Bacteria,2NNMX@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	-	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
SX3_k127_4957326_2	1033810.HLPCO_002490	2.185e-53	205.0	COG0300@1|root,COG0300@2|Bacteria	2|Bacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short
SX3_k127_4957326_0	1123274.KB899409_gene558	3.002e-222	701.0	COG0031@1|root,COG0031@2|Bacteria,2J9V1@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
SX3_k127_499098_1	1499967.BAYZ01000093_gene4019	1.08e-154	499.0	COG1879@1|root,COG1879@2|Bacteria	2|Bacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
SX3_k127_499098_0	1499967.BAYZ01000093_gene4016	2.934e-201	639.0	COG1129@1|root,COG1129@2|Bacteria,2NPR8@2323|unclassified Bacteria	2|Bacteria	G	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
SX3_k127_499098_4	1499967.BAYZ01000093_gene4015	2.459e-114	377.0	COG1172@1|root,COG1172@2|Bacteria	2|Bacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
SX3_k127_499098_3	1499967.BAYZ01000093_gene4014	9.129e-121	395.0	COG1172@1|root,COG1172@2|Bacteria	2|Bacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
SX3_k127_499098_2	1499967.BAYZ01000093_gene4012	1.564e-152	517.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
SX3_k127_499098_5	511051.CSE_13730	1.741e-39	156.0	COG1349@1|root,COG1349@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	DeoRC,HTH_DeoR
SX3_k127_499098_6	471853.Bcav_2140	8.775e-05	46.0	COG0270@1|root,COG0270@2|Bacteria,2I8R8@201174|Actinobacteria	201174|Actinobacteria	H	Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family	-	-	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_methylase
SX3_k127_5079487_2	446466.Cfla_2943	1.248e-05	50.0	COG3905@1|root,COG3905@2|Bacteria,2GWKG@201174|Actinobacteria	201174|Actinobacteria	K	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source	vapB43	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040008,GO:0044464,GO:0045927,GO:0048518,GO:0050789,GO:0065007,GO:0071944	-	-	-	-	-	-	-	-	-	-	RHH_1
SX3_k127_5079487_1	557599.MKAN_24505	4.167e-14	81.0	COG1848@1|root,COG1848@2|Bacteria,2GPX7@201174|Actinobacteria,23B4M@1762|Mycobacteriaceae	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
SX3_k127_5079487_0	886293.Sinac_4718	4.305e-105	349.0	COG0553@1|root,COG0553@2|Bacteria,2IX46@203682|Planctomycetes	203682|Planctomycetes	KL	helicase superfamily c-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N,SWIM
SX3_k127_5135248_25	1304875.JAFZ01000001_gene850	1.062e-34	137.0	COG1028@1|root,COG1028@2|Bacteria,3TAFZ@508458|Synergistetes	508458|Synergistetes	IQ	COGs COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
SX3_k127_5135248_8	1499967.BAYZ01000119_gene3166	1.501e-105	353.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
SX3_k127_5135248_2	292459.STH1195	3.077e-192	624.0	COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,2493W@186801|Clostridia	186801|Clostridia	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
SX3_k127_5135248_29	1123237.Salmuc_02048	6.949e-06	57.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
SX3_k127_5135248_7	1173028.ANKO01000127_gene4126	3.417e-108	366.0	COG0745@1|root,COG2114@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG5002@2|Bacteria,1G2RJ@1117|Cyanobacteria,1H9PS@1150|Oscillatoriales	1117|Cyanobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,HATPase_c,HisKA,PAS_4,Response_reg
SX3_k127_5135248_13	1120950.KB892794_gene2342	8.488e-77	282.0	COG1680@1|root,COG1680@2|Bacteria,2GNNF@201174|Actinobacteria,4DQ3J@85009|Propionibacteriales	201174|Actinobacteria	V	Beta-lactamase	ampC2	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SX3_k127_5135248_18	1410620.SHLA_36c000140	1.322e-58	214.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SX3_k127_5135248_19	553973.CLOHYLEM_05688	1.543e-52	197.0	COG0191@1|root,COG0191@2|Bacteria,1TQ01@1239|Firmicutes,248B7@186801|Clostridia,21Y4P@1506553|Lachnoclostridium	186801|Clostridia	H	Psort location Cytoplasmic, score 8.87	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
SX3_k127_5135248_24	2342.SOPEG_3209	1.27e-37	153.0	COG0223@1|root,COG0451@1|root,COG0223@2|Bacteria,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,1RNJD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	GJM	Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides	arnA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006040,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016741,GO:0016742,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0022607,GO:0033319,GO:0033320,GO:0034214,GO:0034641,GO:0034654,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046349,GO:0046483,GO:0046677,GO:0048037,GO:0048040,GO:0050662,GO:0050896,GO:0051259,GO:0051287,GO:0055086,GO:0055114,GO:0065003,GO:0070403,GO:0071704,GO:0071840,GO:0097159,GO:0099618,GO:0099619,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:2001313,GO:2001315	1.1.1.305,2.1.2.13,5.1.3.2	ko:K01784,ko:K10011	ko00052,ko00520,ko01100,ko01503,map00052,map00520,map01100,map01503	M00361,M00362,M00632,M00721,M00761	R00291,R02984,R07658,R07660	RC00026,RC00289,RC01575,RC01812	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iPC815.YPO2420,iSFV_1184.SFV_2325	Epimerase,Formyl_trans_C,Formyl_trans_N
SX3_k127_5135248_15	1089553.Tph_c04510	1.569e-72	255.0	COG5564@1|root,COG5564@2|Bacteria,1TS71@1239|Firmicutes,24AYD@186801|Clostridia,42HVR@68295|Thermoanaerobacterales	186801|Clostridia	S	Phosphoenolpyruvate hydrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	PEP_hydrolase
SX3_k127_5135248_9	1449126.JQKL01000019_gene3214	2.943e-95	331.0	COG5441@1|root,COG5441@2|Bacteria,1TQ3W@1239|Firmicutes,24A9D@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	UPF0261
SX3_k127_5135248_17	926550.CLDAP_32280	2.576e-66	254.0	COG2390@1|root,COG2390@2|Bacteria,2G8CS@200795|Chloroflexi	200795|Chloroflexi	K	Putative sugar-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r4,Sugar-bind
SX3_k127_5135248_21	634452.APA01_12160	1.194e-42	179.0	COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,2TRXM@28211|Alphaproteobacteria,2JPJK@204441|Rhodospirillales	204441|Rhodospirillales	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
SX3_k127_5135248_10	469381.Dpep_0513	8.971e-92	312.0	COG1071@1|root,COG1071@2|Bacteria,3TA5N@508458|Synergistetes	508458|Synergistetes	C	E1 component	-	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
SX3_k127_5135248_6	1235799.C818_03807	4.358e-120	397.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,249UD@186801|Clostridia	186801|Clostridia	C	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit	-	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
SX3_k127_5135248_11	1007103.AFHW01000057_gene3550	1.98e-90	313.0	COG1653@1|root,COG1653@2|Bacteria,1V1GE@1239|Firmicutes,4I6FY@91061|Bacilli,26SWE@186822|Paenibacillaceae	91061|Bacilli	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
SX3_k127_5135248_16	665950.HMPREF1025_01163	2.166e-71	251.0	COG1175@1|root,COG1175@2|Bacteria,1V26X@1239|Firmicutes,24D0C@186801|Clostridia,27TIJ@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
SX3_k127_5135248_14	1007103.AFHW01000057_gene3552	1.389e-72	271.0	COG0395@1|root,COG0395@2|Bacteria,1TRCP@1239|Firmicutes,4HBKE@91061|Bacilli,26TAK@186822|Paenibacillaceae	91061|Bacilli	P	Sugar ABC transporter permease	lacG	-	-	ko:K02026,ko:K10190,ko:K17243	ko02010,map02010	M00199,M00207,M00600	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.39,3.A.1.1.4	-	-	BPD_transp_1
SX3_k127_5135248_1	926550.CLDAP_12840	2.109e-212	666.0	COG1486@1|root,COG1486@2|Bacteria,2G858@200795|Chloroflexi	200795|Chloroflexi	G	Family 4 glycosyl hydrolase	-	-	3.2.1.22	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
SX3_k127_5135248_27	398525.KB900701_gene2983	6.45e-18	99.0	COG2159@1|root,COG2159@2|Bacteria,1ND2I@1224|Proteobacteria,2UIP1@28211|Alphaproteobacteria,3K498@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
SX3_k127_5135248_23	1122947.FR7_0614	3.643e-39	164.0	COG0778@1|root,COG0778@2|Bacteria,1V4UA@1239|Firmicutes,4H5NF@909932|Negativicutes	909932|Negativicutes	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SX3_k127_5135248_12	240016.ABIZ01000001_gene4511	3.793e-85	290.0	COG1082@1|root,COG1082@2|Bacteria,46SWE@74201|Verrucomicrobia,2IVCZ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SX3_k127_5135248_4	1195236.CTER_0372	1.562e-167	544.0	COG1486@1|root,COG1486@2|Bacteria,1TQ9I@1239|Firmicutes,24995@186801|Clostridia	186801|Clostridia	G	family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
SX3_k127_5135248_22	545694.TREPR_0381	4.738e-42	160.0	COG4393@1|root,COG4393@2|Bacteria,2JAEX@203691|Spirochaetes	203691|Spirochaetes	S	Predicted membrane protein (DUF2318)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2318
SX3_k127_5135248_3	1195236.CTER_0329	3.588e-179	580.0	COG2608@1|root,COG2836@1|root,COG4633@1|root,COG2608@2|Bacteria,COG2836@2|Bacteria,COG4633@2|Bacteria,1TQ02@1239|Firmicutes,249HC@186801|Clostridia,3WNAJ@541000|Ruminococcaceae	186801|Clostridia	P	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1,DsbD_2,HMA
SX3_k127_5135248_30	1267535.KB906767_gene1078	0.000683	47.0	COG2608@1|root,COG2608@2|Bacteria	2|Bacteria	P	mercury ion transmembrane transporter activity	-	-	-	ko:K07213	ko04978,map04978	-	-	-	ko00000,ko00001	-	-	-	HMA
SX3_k127_5135248_20	545695.TREAZ_2097	3.122e-51	192.0	28M3X@1|root,2ZAHZ@2|Bacteria,2JB7I@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5135248_0	653733.Selin_1859	1.076e-212	667.0	COG2873@1|root,COG2873@2|Bacteria	2|Bacteria	E	o-acetylhomoserine	-	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
SX3_k127_5135248_5	868131.MSWAN_1021	1.286e-137	445.0	COG0031@1|root,arCOG01430@2157|Archaea,2XTJR@28890|Euryarchaeota,23NSG@183925|Methanobacteria	183925|Methanobacteria	E	Cysteine synthase	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SX3_k127_5135248_26	56780.SYN_03008	3.237e-31	128.0	COG1959@1|root,COG1959@2|Bacteria,1PC6N@1224|Proteobacteria,43EVM@68525|delta/epsilon subdivisions,2X9SC@28221|Deltaproteobacteria,2MSFF@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
SX3_k127_5135248_28	279010.BL01581	1.63e-14	84.0	COG1940@1|root,COG1940@2|Bacteria,1TPKW@1239|Firmicutes,4HBAU@91061|Bacilli,1ZBV8@1386|Bacillus	91061|Bacilli	G	Glucokinase	glcK	GO:0003674,GO:0003824,GO:0004340,GO:0004396,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044464,GO:0046835,GO:0051156,GO:0071704,GO:1901135	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS07790	ROK
SX3_k127_5159730_1	877418.ATWV01000002_gene1125	7.964e-81	292.0	COG0457@1|root,COG0457@2|Bacteria,2J7YH@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5159730_0	696281.Desru_0559	1.491e-81	286.0	COG0642@1|root,COG0642@2|Bacteria,1UZTI@1239|Firmicutes,24FQ6@186801|Clostridia,264AX@186807|Peptococcaceae	186801|Clostridia	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
SX3_k127_5159730_2	1266925.JHVX01000005_gene1950	2.039e-24	119.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2VMX6@28216|Betaproteobacteria,372PI@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Capsular polysaccharide biosynthesis protein CapK	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,Glyco_transf_4,Glycos_transf_1
SX3_k127_5171007_16	744872.Spica_2151	5.66e-23	101.0	COG1879@1|root,COG1879@2|Bacteria,2J800@203691|Spirochaetes	203691|Spirochaetes	G	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
SX3_k127_5171007_4	158190.SpiGrapes_2639	5.857e-144	469.0	COG1172@1|root,COG1172@2|Bacteria,2J7N5@203691|Spirochaetes	203691|Spirochaetes	G	COG1172 Ribose xylose arabinose galactoside ABC-type transport systems, permease components	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
SX3_k127_5171007_2	158189.SpiBuddy_2502	1.217e-221	699.0	COG1129@1|root,COG1129@2|Bacteria,2J64A@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
SX3_k127_5171007_7	871968.DESME_04290	9.543e-113	383.0	COG1233@1|root,COG1233@2|Bacteria,1TS4A@1239|Firmicutes,249K1@186801|Clostridia,2633J@186807|Peptococcaceae	186801|Clostridia	Q	amine oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
SX3_k127_5171007_9	744872.Spica_1991	1.823e-81	283.0	COG3858@1|root,COG3858@2|Bacteria,2J6UU@203691|Spirochaetes	203691|Spirochaetes	S	hydrolase, family 18	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18
SX3_k127_5171007_1	543728.Vapar_0778	4.581e-247	770.0	COG0753@1|root,COG0753@2|Bacteria,1MUXZ@1224|Proteobacteria,2VGZA@28216|Betaproteobacteria,4AA0R@80864|Comamonadaceae	28216|Betaproteobacteria	C	Serves to protect cells from the toxic effects of hydrogen peroxide	katA	-	1.11.1.6	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	M00532	R00009,R00602,R02670	RC00034,RC00767,RC02141,RC02755	ko00000,ko00001,ko00002,ko01000	-	-	-	Catalase,Catalase-rel
SX3_k127_5171007_13	665571.STHERM_c01860	1.543e-34	136.0	COG3118@1|root,COG3118@2|Bacteria,2J865@203691|Spirochaetes	203691|Spirochaetes	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
SX3_k127_5171007_10	665571.STHERM_c01870	2.175e-76	268.0	2EVQY@1|root,33P4X@2|Bacteria,2J6X8@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5171007_12	1123274.KB899426_gene2832	5.407e-49	185.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	GO:0000166,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0017076,GO:0019219,GO:0019222,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0046983,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
SX3_k127_5171007_14	1123274.KB899411_gene3131	3.531e-34	134.0	2C3HB@1|root,333QE@2|Bacteria,2J8P5@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5171007_6	926550.CLDAP_34860	3.062e-118	396.0	COG0508@1|root,COG0508@2|Bacteria	2|Bacteria	C	S-acyltransferase activity	pdhC	-	2.3.1.12,2.3.1.61	ko:K00627,ko:K00658	ko00010,ko00020,ko00310,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00310,map00620,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032,M00307	R00209,R02569,R02570,R02571,R08549	RC00004,RC02727,RC02742,RC02833,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
SX3_k127_5171007_3	1499967.BAYZ01000090_gene4960	3.131e-148	482.0	COG1249@1|root,COG1249@2|Bacteria,2NNTI@2323|unclassified Bacteria	2|Bacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
SX3_k127_5171007_0	1499967.BAYZ01000090_gene4959	0.0	1216.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,2NNT2@2323|unclassified Bacteria	2|Bacteria	C	Transketolase, pyrimidine binding domain	pdhA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00162,ko:K00167,ko:K11381	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
SX3_k127_5171007_11	1304874.JAFY01000002_gene791	2.015e-74	275.0	COG0745@1|root,COG0745@2|Bacteria,3TAJR@508458|Synergistetes	1304874.JAFY01000002_gene791|-	K	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5171007_8	1304874.JAFY01000002_gene790	5.585e-112	387.0	COG5002@1|root,COG5002@2|Bacteria,3T9XA@508458|Synergistetes	2|Bacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
SX3_k127_5171007_15	760568.Desku_2340	9.036e-33	143.0	arCOG09742@1|root,2ZBGR@2|Bacteria,1V0RW@1239|Firmicutes,24AYH@186801|Clostridia,263KV@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5171007_5	1121439.dsat_1867	5.63e-129	418.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,42N9Z@68525|delta/epsilon subdivisions,2WIKQ@28221|Deltaproteobacteria,2M9HW@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	PFAM 6-phosphogluconate dehydrogenase NAD-binding	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
SX3_k127_5171007_19	2903.EOD21773	1.35e-12	75.0	2CYQE@1|root,2S5NM@2759|Eukaryota	2759|Eukaryota	S	Galactokinase galactose-binding signature	-	-	-	-	-	-	-	-	-	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
SX3_k127_519223_14	545694.TREPR_0805	7.526e-28	123.0	2C8R1@1|root,2ZG03@2|Bacteria,2J6QN@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_519223_13	906968.Trebr_1664	2.411e-39	153.0	COG0295@1|root,COG0295@2|Bacteria,2J80W@203691|Spirochaetes	203691|Spirochaetes	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	cdd	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
SX3_k127_519223_2	573413.Spirs_1536	1.233e-89	305.0	2E1YA@1|root,32X70@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_519223_1	889378.Spiaf_2130	3.703e-160	522.0	COG0497@1|root,COG0497@2|Bacteria,2J5E5@203691|Spirochaetes	203691|Spirochaetes	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
SX3_k127_519223_8	545694.TREPR_2934	2.858e-69	248.0	COG0061@1|root,COG0061@2|Bacteria,2J5BE@203691|Spirochaetes	203691|Spirochaetes	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
SX3_k127_519223_7	1123274.KB899413_gene884	7.351e-71	253.0	COG0399@1|root,COG0399@2|Bacteria,2J6I3@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
SX3_k127_519223_10	880072.Desac_1175	7.517e-65	229.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,42QSI@68525|delta/epsilon subdivisions,2WMNJ@28221|Deltaproteobacteria,2MQC2@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
SX3_k127_519223_5	1123274.KB899413_gene886	2.974e-76	268.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIAA-like,Usp
SX3_k127_519223_16	1321778.HMPREF1982_03405	1.16e-14	85.0	COG0775@1|root,COG0775@2|Bacteria	2|Bacteria	F	adenosylhomocysteine nucleosidase activity	pfs	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
SX3_k127_519223_9	765420.OSCT_0524	1.772e-67	243.0	COG0697@1|root,COG0697@2|Bacteria,2G70T@200795|Chloroflexi,3762A@32061|Chloroflexia	32061|Chloroflexia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SX3_k127_519223_6	278957.ABEA03000117_gene1092	1.448e-74	267.0	COG1143@1|root,COG3260@1|root,COG1143@2|Bacteria,COG3260@2|Bacteria,46VST@74201|Verrucomicrobia,3K7DE@414999|Opitutae	414999|Opitutae	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Oxidored_q6
SX3_k127_519223_4	886293.Sinac_2883	7.137e-81	279.0	COG1762@1|root,COG3311@1|root,COG1762@2|Bacteria,COG3311@2|Bacteria,2IZFY@203682|Planctomycetes	203682|Planctomycetes	G	PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	HTH_17,PTS_EIIA_2
SX3_k127_519223_3	907348.TresaDRAFT_0093	6.136e-83	290.0	COG0438@1|root,COG0438@2|Bacteria,2J7E2@203691|Spirochaetes	203691|Spirochaetes	M	PFAM Glycosyl transferases group 1	-	-	2.4.1.337	ko:K19002	ko00561,ko01100,map00561,map01100	-	R10850	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
SX3_k127_519223_11	1033743.CAES01000004_gene2143	1.24e-62	236.0	COG0624@1|root,COG0624@2|Bacteria,1TQS9@1239|Firmicutes,4HDHW@91061|Bacilli,26UDI@186822|Paenibacillaceae	91061|Bacilli	E	Peptidase family M20/M25/M40	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
SX3_k127_519223_12	1121924.ATWH01000005_gene2830	1.367e-59	218.0	COG0363@1|root,COG0363@2|Bacteria,2GZVT@201174|Actinobacteria	201174|Actinobacteria	G	glucosamine-6-phosphate deaminase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_519223_17	264732.Moth_2113	2.235e-08	66.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia,42GAF@68295|Thermoanaerobacterales	186801|Clostridia	K	helix-turn-helix- domain containing protein, AraC type	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,HTH_AraC,Response_reg
SX3_k127_519223_0	1121335.Clst_2417	1.756e-172	548.0	COG0524@1|root,COG0524@2|Bacteria,1TRRY@1239|Firmicutes,248Y3@186801|Clostridia,3WHKM@541000|Ruminococcaceae	186801|Clostridia	G	Kinase, PfkB family	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
SX3_k127_519223_15	1123274.KB899416_gene2647	3.234e-22	96.0	COG1028@1|root,COG1028@2|Bacteria	1123274.KB899416_gene2647|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5254308_14	933262.AXAM01000001_gene369	2.575e-23	101.0	2ANKS@1|root,31DJZ@2|Bacteria,1R1SV@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5254308_8	33035.JPJF01000041_gene299	1.745e-62	229.0	COG0407@1|root,COG0407@2|Bacteria,1USM0@1239|Firmicutes,248G3@186801|Clostridia	186801|Clostridia	H	Methyltransferase MtaA CmuA family	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,URO-D
SX3_k127_5254308_12	1499967.BAYZ01000003_gene5843	6.295e-45	180.0	COG1879@1|root,COG1879@2|Bacteria	2|Bacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K02058,ko:K10439	ko02010,ko02030,map02010,map02030	M00212,M00221	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
SX3_k127_5254308_5	309803.CTN_0239	2.111e-71	253.0	COG1172@1|root,COG1172@2|Bacteria,2GE4I@200918|Thermotogae	200918|Thermotogae	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057,ko:K10440	ko02010,map02010	M00212,M00221	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
SX3_k127_5254308_6	309803.CTN_0238	1.034e-70	247.0	COG1129@1|root,COG1129@2|Bacteria,2GE3R@200918|Thermotogae	200918|Thermotogae	P	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
SX3_k127_5254308_2	1232453.BAIF02000062_gene1856	2.255e-113	376.0	COG1879@1|root,COG1879@2|Bacteria,1TSBH@1239|Firmicutes,24DCJ@186801|Clostridia	186801|Clostridia	G	Periplasmic binding protein LacI transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_4
SX3_k127_5254308_0	1232453.BAIF02000062_gene1857	8.213e-189	602.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,26882@186813|unclassified Clostridiales	186801|Clostridia	G	Part of the ABC transporter complex MglABC involved in galactose methyl galactoside import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
SX3_k127_5254308_3	411684.HPDFL43_01955	7.521e-78	273.0	COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,2TV15@28211|Alphaproteobacteria,43QWW@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
SX3_k127_5254308_4	1123274.KB899407_gene194	1.95e-76	282.0	COG0407@1|root,COG0407@2|Bacteria,2JA7B@203691|Spirochaetes	203691|Spirochaetes	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
SX3_k127_5254308_13	1121430.JMLG01000006_gene1755	6.577e-39	160.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia,261VC@186807|Peptococcaceae	186801|Clostridia	T	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,HTH_AraC,Response_reg
SX3_k127_5254308_10	857293.CAAU_0343	3.71e-57	218.0	COG2972@1|root,COG2972@2|Bacteria,1TSF9@1239|Firmicutes,2499Y@186801|Clostridia,36VHD@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,His_kinase
SX3_k127_5254308_15	518766.Rmar_0609	1.882e-10	69.0	2FFT5@1|root,347QA@2|Bacteria,4P5W2@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4398
SX3_k127_5254308_9	744872.Spica_2479	9.384e-62	233.0	2AMMU@1|root,31CHX@2|Bacteria,2J7FZ@203691|Spirochaetes	203691|Spirochaetes	S	by glimmer	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5254308_1	1499967.BAYZ01000073_gene2038	9.829e-141	452.0	COG0524@1|root,COG0524@2|Bacteria,2NQTT@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	GO:0003674,GO:0003824,GO:0004747,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019303,GO:0019321,GO:0019323,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046835,GO:0071704,GO:1901575	2.7.1.15,2.7.1.4	ko:K00847,ko:K00852	ko00030,ko00051,ko00500,ko00520,ko01100,map00030,map00051,map00500,map00520,map01100	-	R00760,R00867,R01051,R02750,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	iE2348C_1286.E2348C_4062,iEcDH1_1363.EcDH1_4215	PfkB
SX3_k127_5254308_7	1499967.BAYZ01000073_gene2036	1.394e-65	226.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX3_k127_5284793_2	1382358.JHVN01000003_gene2767	8.478e-61	225.0	COG1940@1|root,COG1940@2|Bacteria,1TQCE@1239|Firmicutes,4HDE3@91061|Bacilli,21VCB@150247|Anoxybacillus	91061|Bacilli	GK	ROK family	xylR	-	-	-	-	-	-	-	-	-	-	-	HTH_24,MarR_2,ROK
SX3_k127_5284793_0	1303518.CCALI_00632	4.386e-104	352.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
SX3_k127_5284793_4	278957.ABEA03000196_gene407	9.35e-46	180.0	COG0407@1|root,COG0407@2|Bacteria,46WW7@74201|Verrucomicrobia,3K8TQ@414999|Opitutae	414999|Opitutae	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
SX3_k127_5284793_1	329726.AM1_4939	1.625e-101	352.0	COG0591@1|root,COG0591@2|Bacteria,1G3QJ@1117|Cyanobacteria	1117|Cyanobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
SX3_k127_5284793_3	1123376.AUIU01000011_gene877	9.122e-60	216.0	COG0476@1|root,COG0476@2|Bacteria	2|Bacteria	H	Involved in molybdopterin and thiamine biosynthesis, family 2	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
SX3_k127_5312035_13	1191523.MROS_2631	5.372e-45	166.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10
SX3_k127_5312035_0	696281.Desru_2877	1.146e-277	867.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,260DJ@186807|Peptococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SX3_k127_5312035_2	1499689.CCNN01000014_gene3263	3.415e-254	796.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247T8@186801|Clostridia,36EMB@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SX3_k127_5312035_18	1510531.JQJJ01000008_gene4079	1.38e-12	74.0	COG1846@1|root,COG1846@2|Bacteria,1RDMG@1224|Proteobacteria,2U8D9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
SX3_k127_5312035_17	318424.EU78_05830	5.852e-24	117.0	COG3832@1|root,COG3832@2|Bacteria,2IBWM@201174|Actinobacteria,237CR@1762|Mycobacteriaceae	201174|Actinobacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5312035_3	573413.Spirs_2249	2.188e-157	519.0	COG1593@1|root,COG3090@1|root,COG1593@2|Bacteria,COG3090@2|Bacteria,2J5NW@203691|Spirochaetes	203691|Spirochaetes	G	transporter, DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
SX3_k127_5312035_11	665571.STHERM_c20410	1.241e-67	242.0	COG1638@1|root,COG1638@2|Bacteria,2J5PX@203691|Spirochaetes	203691|Spirochaetes	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
SX3_k127_5312035_10	545695.TREAZ_0940	4.849e-69	255.0	COG5660@1|root,2Z7TM@2|Bacteria,2JBFN@203691|Spirochaetes	203691|Spirochaetes	S	TRAP transporter T-component	-	-	-	-	-	-	-	-	-	-	-	-	TAtT
SX3_k127_5312035_12	1307761.L21SP2_0986	1.871e-60	216.0	COG0546@1|root,COG0546@2|Bacteria	2|Bacteria	S	glycolate biosynthetic process	-	-	3.1.3.18	ko:K01091,ko:K05967,ko:K07025	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD,HAD_2,NT5C
SX3_k127_5312035_4	439235.Dalk_3112	1.677e-115	384.0	COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,1RGKE@1224|Proteobacteria,42QI9@68525|delta/epsilon subdivisions,2WIV3@28221|Deltaproteobacteria,2MI92@213118|Desulfobacterales	28221|Deltaproteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HD,Lactamase_B_2
SX3_k127_5312035_14	1198452.Jab_1c20720	2.52e-29	122.0	COG2314@1|root,COG2314@2|Bacteria,1N8CV@1224|Proteobacteria,2VWM9@28216|Betaproteobacteria	28216|Betaproteobacteria	S	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	TM2
SX3_k127_5312035_16	1304874.JAFY01000005_gene1320	4.656e-28	118.0	COG3467@1|root,COG3467@2|Bacteria,3TBB5@508458|Synergistetes	508458|Synergistetes	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
SX3_k127_5312035_5	1304880.JAGB01000002_gene2035	6.965e-113	382.0	COG2211@1|root,COG2211@2|Bacteria,1URUG@1239|Firmicutes,248SK@186801|Clostridia	186801|Clostridia	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX3_k127_5312035_6	204669.Acid345_3014	1.118e-105	384.0	COG0784@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,3Y64H@57723|Acidobacteria,2JM5F@204432|Acidobacteriia	204432|Acidobacteriia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
SX3_k127_5312035_8	926569.ANT_04390	3.969e-90	312.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
SX3_k127_5312035_15	1123274.KB899409_gene570	8.717e-29	126.0	COG0349@1|root,COG0349@2|Bacteria,2J80E@203691|Spirochaetes	203691|Spirochaetes	L	3'-5' exonuclease	-	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
SX3_k127_5312035_9	1499967.BAYZ01000195_gene3082	3.119e-85	301.0	COG1453@1|root,COG1453@2|Bacteria	2|Bacteria	S	Aldo/keto reductase family	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
SX3_k127_5312035_1	56780.SYN_01978	5.012e-271	842.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42MMK@68525|delta/epsilon subdivisions,2WJC1@28221|Deltaproteobacteria,2MSIG@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	ABC transporter	yjjK	-	3.6.3.25	ko:K06020	-	-	-	-	ko00000,ko01000	-	-	-	ABC_tran,ABC_tran_Xtn
SX3_k127_5312035_19	266117.Rxyl_3170	1.182e-11	76.0	COG0477@1|root,COG2814@2|Bacteria,2H6FB@201174|Actinobacteria	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX3_k127_5312035_7	357808.RoseRS_3026	1.296e-99	357.0	COG0745@1|root,COG2203@1|root,COG2204@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,2G7Y4@200795|Chloroflexi,374VX@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase A domain protein	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA,PAS_4,Response_reg
SX3_k127_5315335_3	909663.KI867150_gene894	6.83e-94	316.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,42MCV@68525|delta/epsilon subdivisions,2WJI2@28221|Deltaproteobacteria,2MQAR@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	TIGRFAM Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
SX3_k127_5315335_1	1121405.dsmv_0216	5.548e-147	480.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42NMZ@68525|delta/epsilon subdivisions,2WIZ0@28221|Deltaproteobacteria,2MINS@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP- dependent clade X sub-subfamily	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
SX3_k127_5315335_0	247490.KSU1_D0386	4.002e-154	497.0	COG0192@1|root,COG0192@2|Bacteria,2IXCJ@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
SX3_k127_5315335_2	1121472.AQWN01000001_gene255	2.333e-107	359.0	COG1180@1|root,COG1180@2|Bacteria,1TP46@1239|Firmicutes,248K9@186801|Clostridia,2617J@186807|Peptococcaceae	186801|Clostridia	C	PFAM Radical SAM	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
SX3_k127_5315335_5	760568.Desku_0519	0.0001774	52.0	COG1961@1|root,COG1961@2|Bacteria,1TS5B@1239|Firmicutes,248MZ@186801|Clostridia,264A2@186807|Peptococcaceae	186801|Clostridia	L	Resolvase, N terminal domain	-	-	-	ko:K06400	-	-	-	-	ko00000	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
SX3_k127_5315335_4	1035191.HMPREF0185_03281	9.081e-40	152.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,2KH7K@204458|Caulobacterales	204458|Caulobacterales	L	Recombinase zinc beta ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
SX3_k127_5318096_3	452637.Oter_3478	7.85e-27	111.0	COG0059@1|root,COG0059@2|Bacteria,46SI2@74201|Verrucomicrobia,3K7PK@414999|Opitutae	74201|Verrucomicrobia	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
SX3_k127_5318096_1	553385.JEMF01000022_gene3172	2.264e-83	289.0	COG0583@1|root,COG0583@2|Bacteria,1MZX1@1224|Proteobacteria,1RNFR@1236|Gammaproteobacteria,1XH35@135619|Oceanospirillales	135619|Oceanospirillales	K	transcriptional regulator	-	-	-	ko:K02521	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
SX3_k127_5318096_0	744872.Spica_0276	2.505e-117	392.0	COG2885@1|root,COG2885@2|Bacteria,2J6IG@203691|Spirochaetes	203691|Spirochaetes	M	ompA family	tpn50	-	-	-	-	-	-	-	-	-	-	-	OmpA
SX3_k127_5318096_2	573413.Spirs_0468	1.208e-28	132.0	COG0513@1|root,COG0724@1|root,COG0513@2|Bacteria,COG0724@2|Bacteria,2J7A1@203691|Spirochaetes	203691|Spirochaetes	L	DbpA RNA binding domain	-	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA
SX3_k127_5375134_20	196162.Noca_2379	0.0007362	51.0	COG1940@1|root,COG1940@2|Bacteria,2GPEI@201174|Actinobacteria,4DQQU@85009|Propionibacteriales	201174|Actinobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	ROK
SX3_k127_5375134_0	240016.ABIZ01000001_gene281	1.113e-143	469.0	COG0160@1|root,COG0160@2|Bacteria,46UEH@74201|Verrucomicrobia,2IVU9@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Aminotransferase class-III	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
SX3_k127_5375134_8	545694.TREPR_0295	1.449e-66	239.0	COG4324@1|root,COG4324@2|Bacteria,2JA2N@203691|Spirochaetes	203691|Spirochaetes	S	Putative aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Aminopep
SX3_k127_5375134_11	511051.CSE_10260	9.925e-47	173.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	rve
SX3_k127_5375134_18	1273103.NM10_02749	0.0002045	45.0	COG1669@1|root,COG1669@2|Bacteria,1VBYU@1239|Firmicutes,4H48G@909932|Negativicutes	909932|Negativicutes	S	Nucleotidyltransferase substrate binding protein	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2,NTase_sub_bind
SX3_k127_5375134_19	1304880.JAGB01000001_gene900	0.0003338	46.0	COG1708@1|root,COG1708@2|Bacteria,1VGI3@1239|Firmicutes,25DNG@186801|Clostridia	186801|Clostridia	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
SX3_k127_5375134_10	525904.Tter_0922	4.458e-57	207.0	COG2120@1|root,COG2120@2|Bacteria,2NPAV@2323|unclassified Bacteria	2|Bacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
SX3_k127_5375134_1	1047013.AQSP01000100_gene587	4.049e-129	425.0	COG2271@1|root,COG2271@2|Bacteria	2|Bacteria	G	transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX3_k127_5375134_12	1122962.AULH01000008_gene2167	2.062e-31	126.0	2DYQS@1|root,32V5T@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5375134_7	545695.TREAZ_0377	1.59e-79	275.0	COG3039@1|root,COG3039@2|Bacteria,2J8QG@203691|Spirochaetes	203691|Spirochaetes	L	hmm pf01609	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
SX3_k127_5375134_13	977880.pRALTA_0248	3.501e-19	89.0	COG2801@1|root,COG2801@2|Bacteria,1PBHA@1224|Proteobacteria,2VKPT@28216|Betaproteobacteria,1K6KM@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve,rve_3
SX3_k127_5375134_15	1121438.JNJA01000010_gene1945	2.066e-10	65.0	COG4249@1|root,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	atmc2	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
SX3_k127_5375134_14	1047013.AQSP01000126_gene2748	4.032e-18	87.0	COG0677@1|root,COG0677@2|Bacteria,2NNV9@2323|unclassified Bacteria	2|Bacteria	M	UDP binding domain	-	-	1.1.1.136	ko:K02474,ko:K13015	ko00520,map00520	-	R00421,R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
SX3_k127_5375134_16	545695.TREAZ_0579	2.679e-06	51.0	COG2801@1|root,COG2801@2|Bacteria,2J6UX@203691|Spirochaetes	2|Bacteria	L	hmm pf00665	-	-	-	-	-	-	-	-	-	-	-	-	rve
SX3_k127_5375134_9	497964.CfE428DRAFT_2432	4.4e-65	231.0	COG2207@1|root,COG2207@2|Bacteria,46STY@74201|Verrucomicrobia	74201|Verrucomicrobia	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,PAS_4
SX3_k127_5375134_3	1502724.FF80_03140	2.402e-103	347.0	COG3842@1|root,COG3842@2|Bacteria,1QYZ3@1224|Proteobacteria,2TT89@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the ABC transporter superfamily	yurJ	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
SX3_k127_5375134_2	1128421.JAGA01000001_gene2217	2.704e-106	357.0	COG3842@1|root,COG3842@2|Bacteria,2NNU0@2323|unclassified Bacteria	2|Bacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE
SX3_k127_5375134_4	1547437.LL06_07385	1.443e-91	321.0	COG0395@1|root,COG0395@2|Bacteria,1MVVT@1224|Proteobacteria,2TU85@28211|Alphaproteobacteria,43NBE@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	ABC-type sugar transport system, permease component	-	-	-	ko:K02026,ko:K10229	ko02010,map02010	M00200,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.5	-	-	BPD_transp_1
SX3_k127_5375134_6	1128421.JAGA01000001_gene2214	1.239e-80	280.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	ko:K02025,ko:K15771	ko02010,map02010	M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
SX3_k127_5375134_5	1040983.AXAE01000023_gene71	1.362e-83	284.0	COG1653@1|root,COG1653@2|Bacteria,1N8AS@1224|Proteobacteria,2U19M@28211|Alphaproteobacteria,43P25@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
SX3_k127_5423461_1	857087.Metme_0872	1.613e-77	269.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,1RRMU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_28,HTH_32
SX3_k127_5423461_11	269797.Mbar_A3441	2.231e-06	52.0	COG0535@1|root,arCOG00938@2157|Archaea,2Y8D5@28890|Euryarchaeota,2NBPE@224756|Methanomicrobia	224756|Methanomicrobia	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM
SX3_k127_5423461_10	1392490.JHZX01000001_gene3072	3.625e-20	103.0	COG3055@1|root,COG3055@2|Bacteria,4NMHY@976|Bacteroidetes,1I1DN@117743|Flavobacteriia	976|Bacteroidetes	Q	Kelch motif	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_1
SX3_k127_5423461_6	927658.AJUM01000047_gene3023	2.057e-35	140.0	COG0846@1|root,COG0846@2|Bacteria,4NE9Q@976|Bacteroidetes,2FWW9@200643|Bacteroidia,3XJI2@558415|Marinilabiliaceae	976|Bacteroidetes	K	Sir2 family	-	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
SX3_k127_5423461_7	1173024.KI912151_gene2429	5.336e-23	100.0	COG2026@1|root,COG2026@2|Bacteria,1G9NI@1117|Cyanobacteria	1117|Cyanobacteria	DJ	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
SX3_k127_5423461_9	315456.RF_0779	7.153e-21	94.0	COG2161@1|root,COG2161@2|Bacteria,1N7B5@1224|Proteobacteria	1224|Proteobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
SX3_k127_5423461_5	886379.AEWI01000028_gene248	1.648e-37	144.0	COG0846@1|root,COG0846@2|Bacteria,4NE9Q@976|Bacteroidetes,2FWW9@200643|Bacteroidia,3XJI2@558415|Marinilabiliaceae	976|Bacteroidetes	K	Sir2 family	-	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
SX3_k127_5423461_8	566461.SSFG_03488	4.595e-22	111.0	COG2220@1|root,COG2220@2|Bacteria,2GMFQ@201174|Actinobacteria	201174|Actinobacteria	S	Zn-dependent hydrolases of the beta-lactamase fold	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Lactamase_B_3
SX3_k127_5423461_0	929556.Solca_0499	5.137e-102	347.0	COG4452@1|root,COG4452@2|Bacteria,4NGKY@976|Bacteroidetes,1IPKH@117747|Sphingobacteriia	976|Bacteroidetes	V	Inner membrane protein CreD	creD	-	-	ko:K06143	-	-	-	-	ko00000	-	-	-	CreD
SX3_k127_5423461_2	744980.TRICHSKD4_1462	7.633e-67	235.0	COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,2TR43@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	chvI	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K14981	ko02020,map02020	M00520	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SX3_k127_5423461_3	1380391.JIAS01000014_gene2095	1.444e-66	249.0	COG5002@1|root,COG5002@2|Bacteria,1QU7C@1224|Proteobacteria,2TWBW@28211|Alphaproteobacteria,2JPN9@204441|Rhodospirillales	204441|Rhodospirillales	T	Stimulus-sensing domain	chvG	-	2.7.13.3	ko:K14980	ko02020,map02020	M00520	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,Sensor_TM1,Stimulus_sens_1
SX3_k127_5423461_4	665571.STHERM_c21800	1.584e-58	209.0	COG0791@1|root,COG0791@2|Bacteria,2JB19@203691|Spirochaetes	203691|Spirochaetes	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	CHAP,NLPC_P60
SX3_k127_5491637_1	744872.Spica_0395	1.548e-61	215.0	COG0093@1|root,COG0093@2|Bacteria,2J7N1@203691|Spirochaetes	203691|Spirochaetes	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
SX3_k127_5491637_3	1519439.JPJG01000018_gene253	2.232e-26	110.0	COG0186@1|root,COG0186@2|Bacteria,1V9YC@1239|Firmicutes,24MSW@186801|Clostridia,2N7HD@216572|Oscillospiraceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
SX3_k127_5491637_4	1480694.DC28_14315	2.704e-14	76.0	COG0255@1|root,COG0255@2|Bacteria,2J8R5@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
SX3_k127_5491637_0	744872.Spica_0392	1.115e-66	229.0	COG0197@1|root,COG0197@2|Bacteria,2J7H3@203691|Spirochaetes	203691|Spirochaetes	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
SX3_k127_5491637_2	1123274.KB899411_gene3107	2.476e-38	146.0	COG0092@1|root,COG0092@2|Bacteria,2J5AK@203691|Spirochaetes	203691|Spirochaetes	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
SX3_k127_5574_2	1123274.KB899414_gene3674	4.129e-91	312.0	COG0322@1|root,COG0322@2|Bacteria,2J69M@203691|Spirochaetes	203691|Spirochaetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
SX3_k127_5574_3	1123274.KB899414_gene3682	4.847e-86	311.0	COG4733@1|root,COG4733@2|Bacteria,2JBHZ@203691|Spirochaetes	203691|Spirochaetes	S	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,fn3
SX3_k127_5574_4	545695.TREAZ_1637	7.682e-85	314.0	COG0457@1|root,COG0457@2|Bacteria,2J58Z@203691|Spirochaetes	203691|Spirochaetes	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_19,TPR_2,TPR_7,TPR_8
SX3_k127_5574_1	573413.Spirs_4078	5.387e-119	389.0	COG1639@1|root,COG1639@2|Bacteria,2J74B@203691|Spirochaetes	203691|Spirochaetes	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
SX3_k127_5574_0	573413.Spirs_4079	4.514e-140	455.0	COG1235@1|root,COG1235@2|Bacteria,2J6YX@203691|Spirochaetes	203691|Spirochaetes	S	Beta-lactamase superfamily domain	elaC	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Lactamase_B_2
SX3_k127_5574_5	1203606.HMPREF1526_01610	5.239e-78	277.0	COG0407@1|root,COG0407@2|Bacteria,1TSSK@1239|Firmicutes,24CHA@186801|Clostridia,36VVK@31979|Clostridiaceae	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_5574_8	33035.JPJF01000014_gene4755	7.994e-24	112.0	COG1402@1|root,COG1402@2|Bacteria,1TUPT@1239|Firmicutes,259JU@186801|Clostridia,3Y23Z@572511|Blautia	186801|Clostridia	S	Creatinine amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Creatininase
SX3_k127_5574_6	333138.LQ50_08620	9.485e-44	161.0	COG1695@1|root,COG1695@2|Bacteria,1VA8U@1239|Firmicutes,4HKPC@91061|Bacilli,1ZGYN@1386|Bacillus	91061|Bacilli	K	PadR family transcriptional regulator	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
SX3_k127_5574_7	1408422.JHYF01000004_gene1703	3.602e-30	130.0	COG4709@1|root,COG4709@2|Bacteria,1VBDQ@1239|Firmicutes,24M4E@186801|Clostridia,36K1Z@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF1700)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1700
SX3_k127_5574_9	536227.CcarbDRAFT_3918	1.684e-11	74.0	COG3595@1|root,COG3595@2|Bacteria,1VD1Z@1239|Firmicutes,24F2A@186801|Clostridia,36FP1@31979|Clostridiaceae	186801|Clostridia	S	Putative adhesin	-	-	-	ko:K11621	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	DUF4097
SX3_k127_569262_28	1242864.D187_001047	2.194e-45	168.0	COG5184@1|root,COG5184@2|Bacteria,1R504@1224|Proteobacteria,42QHC@68525|delta/epsilon subdivisions,2WKUI@28221|Deltaproteobacteria,2YU2V@29|Myxococcales	28221|Deltaproteobacteria	DZ	Alpha-tubulin suppressor and related RCC1 domain-containing	-	-	-	-	-	-	-	-	-	-	-	-	RCC1
SX3_k127_569262_22	665571.STHERM_c16550	4.736e-67	244.0	COG0451@1|root,COG0451@2|Bacteria,2J8I0@203691|Spirochaetes	203691|Spirochaetes	M	NAD(P)H-binding	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
SX3_k127_569262_47	573413.Spirs_0325	0.0003668	48.0	COG0664@1|root,COG0664@2|Bacteria,2J6CX@203691|Spirochaetes	203691|Spirochaetes	T	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_569262_39	906968.Trebr_1931	1.109e-12	71.0	2AMYN@1|root,31CVT@2|Bacteria,2J8ZK@203691|Spirochaetes	203691|Spirochaetes	S	TRL-like protein family	-	-	-	-	-	-	-	-	-	-	-	-	TRL
SX3_k127_569262_42	517418.Ctha_2657	5.398e-06	56.0	2BYCE@1|root,348RS@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_569262_45	999141.GME_10856	2.669e-05	57.0	COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,1RMQF@1236|Gammaproteobacteria,1XH2N@135619|Oceanospirillales	135619|Oceanospirillales	G	Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides	nagZ	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
SX3_k127_569262_30	745277.GRAQ_02792	1.833e-42	169.0	COG0697@1|root,COG0697@2|Bacteria,1MVGC@1224|Proteobacteria,1RMXB@1236|Gammaproteobacteria,3FF4K@34037|Rahnella	1236|Gammaproteobacteria	EG	EamA-like transporter family	yddG	GO:0003333,GO:0003674,GO:0005215,GO:0005302,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015179,GO:0015192,GO:0015196,GO:0015238,GO:0015318,GO:0015711,GO:0015801,GO:0015807,GO:0015823,GO:0015827,GO:0015828,GO:0015849,GO:0015893,GO:0016020,GO:0022857,GO:0034220,GO:0042221,GO:0042493,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903825,GO:1905039	-	-	-	-	-	-	-	-	-	iBWG_1329.BWG_1294,iE2348C_1286.E2348C_1607,iECDH10B_1368.ECDH10B_1604,iECDH1ME8569_1439.ECDH1ME8569_1416,iECS88_1305.ECS88_1565,iEcDH1_1363.EcDH1_2175,iJO1366.b1473,iNRG857_1313.NRG857_07295,iSSON_1240.SSON_1651,iUMN146_1321.UM146_09675	EamA
SX3_k127_569262_26	96561.Dole_0663	1.299e-54	203.0	COG1280@1|root,COG1280@2|Bacteria,1RJBR@1224|Proteobacteria,42T9G@68525|delta/epsilon subdivisions,2WP76@28221|Deltaproteobacteria,2MKPW@213118|Desulfobacterales	28221|Deltaproteobacteria	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
SX3_k127_569262_4	1382306.JNIM01000001_gene663	4.23e-196	640.0	COG2366@1|root,COG2366@2|Bacteria,2G63N@200795|Chloroflexi	200795|Chloroflexi	S	PFAM peptidase S45 penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
SX3_k127_569262_12	639283.Snov_3500	4.756e-126	437.0	COG3875@1|root,COG3875@2|Bacteria,1R79Y@1224|Proteobacteria,2U4VR@28211|Alphaproteobacteria,3F0QU@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
SX3_k127_569262_7	316067.Geob_1154	1.307e-152	494.0	COG2223@1|root,COG2223@2|Bacteria,1MWC7@1224|Proteobacteria,42PMA@68525|delta/epsilon subdivisions,2X5AR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Major facilitator superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
SX3_k127_569262_36	644282.Deba_1459	7.204e-26	123.0	COG4191@1|root,COG4191@2|Bacteria,1R02T@1224|Proteobacteria,43CPU@68525|delta/epsilon subdivisions,2X7X1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM histidine kinase, HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365
SX3_k127_569262_29	383372.Rcas_2639	4.063e-43	177.0	COG0642@1|root,COG2205@2|Bacteria,2GBI0@200795|Chloroflexi,3766M@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,HisKA_7TM,PAS_4
SX3_k127_569262_5	596151.DesfrDRAFT_0116	4.538e-189	607.0	COG1620@1|root,COG1620@2|Bacteria,1MV13@1224|Proteobacteria,42NEP@68525|delta/epsilon subdivisions,2WMIU@28221|Deltaproteobacteria,2MGD5@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM L-lactate permease	-	-	-	ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14	-	-	Lactate_perm
SX3_k127_569262_2	1499967.BAYZ01000131_gene362	6.108e-216	682.0	COG2407@1|root,COG2407@2|Bacteria	2|Bacteria	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_Isome,Fucose_iso_C
SX3_k127_569262_1	1499967.BAYZ01000159_gene498	4.146e-249	781.0	COG1069@1|root,COG1069@2|Bacteria,2NQNS@2323|unclassified Bacteria	2|Bacteria	G	FGGY family of carbohydrate kinases, N-terminal domain	araB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008741,GO:0009056,GO:0009058,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0019569,GO:0019572,GO:0019637,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0046373,GO:0046835,GO:0051167,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901159,GO:1901575,GO:1901576	2.7.1.16	ko:K00853	ko00040,ko01100,map00040,map01100	-	R01526,R02439	RC00002,RC00538	ko00000,ko00001,ko01000	-	-	iBWG_1329.BWG_0059,iECH74115_1262.ECH74115_0068,iECSP_1301.ECSP_0067,iECs_1301.ECs0067,iG2583_1286.G2583_0066,iPC815.YPO2254,iZ_1308.Z0072	FGGY_C,FGGY_N
SX3_k127_569262_18	575788.VS_II0142	2.15e-89	300.0	COG0235@1|root,COG0235@2|Bacteria,1MU54@1224|Proteobacteria,1RMIP@1236|Gammaproteobacteria,1XUM8@135623|Vibrionales	135623|Vibrionales	G	COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases	araD	-	5.1.3.4	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R05850	RC01479	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
SX3_k127_569262_25	216594.MMAR_3323	2.102e-63	230.0	COG1071@1|root,COG1071@2|Bacteria,2IBRC@201174|Actinobacteria,234F0@1762|Mycobacteriaceae	201174|Actinobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
SX3_k127_569262_17	216594.MMAR_3322	2.775e-98	331.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,233TJ@1762|Mycobacteriaceae	201174|Actinobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase	-	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
SX3_k127_569262_8	66377.JOBH01000002_gene716	1.716e-149	492.0	COG2721@1|root,COG2721@2|Bacteria,2GJC8@201174|Actinobacteria	201174|Actinobacteria	G	D-galactarate dehydratase Altronate	-	-	4.2.1.42,4.2.1.7	ko:K01685,ko:K01708	ko00040,ko00053,ko01100,map00040,map00053,map01100	M00631	R01540,R05608	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C,SAF
SX3_k127_569262_38	762983.HMPREF9444_00004	2.736e-13	74.0	COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria	1224|Proteobacteria	S	ATPase (AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
SX3_k127_569262_24	1232453.BAIF02000067_gene2012	8.486e-64	231.0	COG0407@1|root,COG0407@2|Bacteria,1USM0@1239|Firmicutes,248G3@186801|Clostridia	186801|Clostridia	H	Methyltransferase MtaA CmuA family	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,URO-D
SX3_k127_569262_9	502025.Hoch_4238	4.738e-141	466.0	COG1109@1|root,COG1482@1|root,COG1109@2|Bacteria,COG1482@2|Bacteria,1MUD8@1224|Proteobacteria,42QR1@68525|delta/epsilon subdivisions,2WU24@28221|Deltaproteobacteria,2YUXK@29|Myxococcales	28221|Deltaproteobacteria	G	Phosphomannose isomerase type I	-	-	5.3.1.8,5.4.2.8	ko:K01809,ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818,R01819	RC00376,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PMI_typeI
SX3_k127_569262_15	1142394.PSMK_28660	1.362e-113	377.0	COG0836@1|root,COG0836@2|Bacteria,2IXAR@203682|Planctomycetes	203682|Planctomycetes	M	Mannose-1-phosphate guanylyltransferase	-	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
SX3_k127_569262_34	203275.BFO_0308	3.155e-30	132.0	COG0615@1|root,COG2605@1|root,COG0615@2|Bacteria,COG2605@2|Bacteria,4NGSD@976|Bacteroidetes,2FQ1X@200643|Bacteroidia,22WKK@171551|Porphyromonadaceae	976|Bacteroidetes	IM	Cytidylyltransferase-like	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like,GHMP_kinases_C
SX3_k127_569262_31	1349822.NSB1T_02690	8.904e-42	175.0	COG0615@1|root,COG2605@1|root,COG0615@2|Bacteria,COG2605@2|Bacteria,4NGSD@976|Bacteroidetes,2FQ1X@200643|Bacteroidia,22WKK@171551|Porphyromonadaceae	976|Bacteroidetes	IM	Cytidylyltransferase-like	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like,GHMP_kinases_C
SX3_k127_569262_11	1205680.CAKO01000003_gene3681	5.086e-130	424.0	COG0451@1|root,COG0451@2|Bacteria,1MUGT@1224|Proteobacteria,2TRF6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction	-	-	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R05692	RC01014	ko00000,ko00001,ko01000	-	-	-	Epimerase
SX3_k127_569262_13	889378.Spiaf_2336	1.807e-124	425.0	COG0210@1|root,COG0210@2|Bacteria,2J7FY@203691|Spirochaetes	203691|Spirochaetes	L	Participates in both transcription termination and antitermination	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,UvrD-helicase,UvrD_C
SX3_k127_569262_27	744872.Spica_0686	2.571e-50	187.0	2BYH0@1|root,2ZDJM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_569262_3	338966.Ppro_1376	6.413e-201	640.0	COG1785@1|root,COG1785@2|Bacteria,1MXI2@1224|Proteobacteria,42N40@68525|delta/epsilon subdivisions,2WKUV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Belongs to the alkaline phosphatase family	phoA	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase
SX3_k127_569262_43	383372.Rcas_2416	6.775e-06	59.0	COG1669@1|root,COG1669@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
SX3_k127_569262_46	45351.EDO31860	0.0001384	54.0	2DZUA@1|root,2S7AZ@2759|Eukaryota,3A71P@33154|Opisthokonta,3C454@33208|Metazoa	33208|Metazoa	S	Cysteine-rich and transmembrane domain-containing protein 1	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_569262_14	1166018.FAES_3360	5.114e-116	384.0	COG0604@1|root,COG0604@2|Bacteria,4NPBM@976|Bacteroidetes,47Q08@768503|Cytophagia	976|Bacteroidetes	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
SX3_k127_569262_32	1499967.BAYZ01000103_gene3728	1.937e-40	151.0	COG2350@1|root,COG2350@2|Bacteria,2NR74@2323|unclassified Bacteria	2|Bacteria	S	YCII-related domain	-	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
SX3_k127_569262_35	1123274.KB899432_gene2938	8.933e-29	122.0	COG1917@1|root,COG1917@2|Bacteria,2JB5G@203691|Spirochaetes	203691|Spirochaetes	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SX3_k127_569262_10	1452718.JBOY01000171_gene1561	1.177e-133	449.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.5,3.6.1.45	ko:K01081,ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
SX3_k127_569262_16	1499967.BAYZ01000076_gene841	2.341e-102	344.0	COG1453@1|root,COG1453@2|Bacteria	2|Bacteria	S	Aldo/keto reductase family	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
SX3_k127_569262_44	158190.SpiGrapes_3038	1.096e-05	55.0	28Y5G@1|root,2ZK0U@2|Bacteria,2JB1C@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_569262_20	1123508.JH636440_gene2839	6.008e-76	269.0	COG2304@1|root,COG2304@2|Bacteria,2IYXD@203682|Planctomycetes	203682|Planctomycetes	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA
SX3_k127_569262_6	1313421.JHBV01000041_gene3629	2.581e-169	559.0	COG2304@1|root,COG2304@2|Bacteria,4NK2W@976|Bacteroidetes	976|Bacteroidetes	M	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	OmpA,VIT,VWA,VWA_3
SX3_k127_569262_37	877455.Metbo_1024	1.125e-20	101.0	arCOG04964@1|root,arCOG04964@2157|Archaea,2XZQX@28890|Euryarchaeota,23P5Z@183925|Methanobacteria	183925|Methanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_569262_23	1079460.ATTQ01000003_gene1535	2.552e-66	236.0	COG1830@1|root,COG1830@2|Bacteria,1N4VG@1224|Proteobacteria,2UE4V@28211|Alphaproteobacteria,4BCMB@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	DeoC/LacD family aldolase	-	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
SX3_k127_569262_21	478741.JAFS01000001_gene1978	2.154e-71	248.0	COG2360@1|root,COG2360@2|Bacteria,46VHR@74201|Verrucomicrobia,37GDI@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
SX3_k127_569262_19	744872.Spica_1887	1.083e-87	303.0	COG0477@1|root,COG2814@2|Bacteria,2JAJU@203691|Spirochaetes	203691|Spirochaetes	EGP	Major Facilitator Superfamily	-	-	-	ko:K08161	-	-	-	-	ko00000,ko02000	2.A.1.2.20	-	-	MFS_1
SX3_k127_569262_0	665571.STHERM_c12610	2.475e-278	875.0	COG0542@1|root,COG0542@2|Bacteria,2J6BU@203691|Spirochaetes	203691|Spirochaetes	O	ATP-dependent Clp protease ATP-binding subunit ClpA	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
SX3_k127_569262_33	56780.SYN_02377	2.701e-33	131.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,42TN3@68525|delta/epsilon subdivisions,2WQ23@28221|Deltaproteobacteria,2MS9E@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
SX3_k127_569262_40	1123270.ATUR01000007_gene1387	7.333e-11	74.0	COG0477@1|root,COG2814@2|Bacteria,1QYNP@1224|Proteobacteria,2U1VX@28211|Alphaproteobacteria,2K97C@204457|Sphingomonadales	204457|Sphingomonadales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX3_k127_569262_41	1267533.KB906735_gene4497	1.618e-07	64.0	COG1361@1|root,COG1470@1|root,COG4733@1|root,COG1361@2|Bacteria,COG1470@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	DUF11,PEGA
SX3_k127_5902280_1	330214.NIDE0628	3.693e-08	64.0	COG0810@1|root,COG0810@2|Bacteria,3J0U0@40117|Nitrospirae	40117|Nitrospirae	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
SX3_k127_5902280_0	926561.KB900617_gene1659	1.213e-59	230.0	COG4206@1|root,COG4206@2|Bacteria,1V287@1239|Firmicutes,24SUD@186801|Clostridia,3WB9E@53433|Halanaerobiales	186801|Clostridia	H	TonB-dependent Receptor Plug	-	-	-	ko:K02014,ko:K16089	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.1,1.B.14.10	-	-	Plug,TonB_dep_Rec
SX3_k127_5929735_1	1307761.L21SP2_0672	3.536e-18	90.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1,Y2_Tnp,Zn_Tnp_IS91
SX3_k127_5929735_2	439235.Dalk_4420	3.506e-09	68.0	COG1835@1|root,COG1835@2|Bacteria,1R4CU@1224|Proteobacteria,42USJ@68525|delta/epsilon subdivisions,2WQ3J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
SX3_k127_5936442_16	1506583.JQJY01000001_gene411	2.548e-08	64.0	COG0642@1|root,COG0745@1|root,COG1879@1|root,COG0745@2|Bacteria,COG1879@2|Bacteria,COG2205@2|Bacteria,4NDXU@976|Bacteroidetes,1HXUN@117743|Flavobacteriia,2NUY8@237|Flavobacterium	976|Bacteroidetes	T	Periplasmic binding proteins and sugar binding domain of LacI family	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Peripla_BP_4,Response_reg
SX3_k127_5936442_12	445972.ANACOL_04122	4.096e-22	100.0	COG0346@1|root,COG0346@2|Bacteria,1VFT2@1239|Firmicutes,24R0F@186801|Clostridia	186801|Clostridia	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
SX3_k127_5936442_4	1122947.FR7_1360	3.124e-118	401.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes	1239|Firmicutes	E	Dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
SX3_k127_5936442_3	1122947.FR7_1359	8.121e-129	419.0	COG1082@1|root,COG1082@2|Bacteria,1TPJT@1239|Firmicutes	1239|Firmicutes	G	Xylose isomerase	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
SX3_k127_5936442_1	1499967.BAYZ01000067_gene6042	6.088e-201	638.0	COG1070@1|root,COG1070@2|Bacteria	2|Bacteria	G	xylulokinase activity	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
SX3_k127_5936442_5	1499967.BAYZ01000067_gene6041	3.358e-81	277.0	COG0274@1|root,COG0274@2|Bacteria,2NP8Z@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
SX3_k127_5936442_9	570952.ATVH01000015_gene1437	2.617e-57	207.0	COG1335@1|root,COG1335@2|Bacteria,1QK2B@1224|Proteobacteria,2U5X9@28211|Alphaproteobacteria,2JTV0@204441|Rhodospirillales	204441|Rhodospirillales	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
SX3_k127_5936442_2	621372.ACIH01000032_gene602	9.319e-130	431.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,4H9VK@91061|Bacilli,26SVT@186822|Paenibacillaceae	91061|Bacilli	G	import. Responsible for energy coupling to the transport system	rbsA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0006810,GO:0008144,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015146,GO:0015399,GO:0015405,GO:0015407,GO:0015591,GO:0015608,GO:0015611,GO:0015749,GO:0015750,GO:0015752,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034219,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043211,GO:0043492,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0097159,GO:0097367,GO:1901265,GO:1901363	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
SX3_k127_5936442_6	586413.CCDL010000001_gene710	4.889e-73	258.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,4H9Y3@91061|Bacilli,23KAP@182709|Oceanobacillus	91061|Bacilli	G	Branched-chain amino acid transport system / permease component	rbsC	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
SX3_k127_5936442_10	484770.UFO1_3460	6.079e-44	173.0	COG1879@1|root,COG1879@2|Bacteria,1TQ1B@1239|Firmicutes,4H3VQ@909932|Negativicutes	909932|Negativicutes	G	sugar-binding domain protein	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
SX3_k127_5936442_11	309801.trd_1464	9.445e-25	113.0	COG0637@1|root,COG0637@2|Bacteria,2G6ZZ@200795|Chloroflexi,27YBK@189775|Thermomicrobia	189775|Thermomicrobia	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
SX3_k127_5936442_7	556261.HMPREF0240_00555	6.397e-71	252.0	COG0407@1|root,COG0407@2|Bacteria,1URPV@1239|Firmicutes,24XIW@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_5936442_0	443143.GM18_1319	0.0	3828.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,42PFN@68525|delta/epsilon subdivisions,2WJVD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	glycosyltransferase 36 associated	-	-	2.4.1.20	ko:K00702,ko:K13688	ko00500,ko01100,map00500,map01100	-	R00952	RC00049	ko00000,ko00001,ko01000,ko01003	-	GH94,GT36,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
SX3_k127_5936442_13	192952.MM_0960	6.882e-14	76.0	COG0071@1|root,arCOG01838@2157|Archaea,2Y1IR@28890|Euryarchaeota,2NBAW@224756|Methanomicrobia	224756|Methanomicrobia	O	response to heat	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
SX3_k127_5936442_15	1337936.IJ00_08355	5.207e-10	63.0	2BK9M@1|root,32EPT@2|Bacteria,1G703@1117|Cyanobacteria,1HS5Z@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5936442_17	1499967.BAYZ01000036_gene2414	0.0001411	45.0	2BK9M@1|root,32EPT@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5936442_14	1121335.Clst_0441	1.025e-12	81.0	2CEJC@1|root,32R1S@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5936442_8	720554.Clocl_3963	7.724e-60	215.0	COG0535@1|root,COG0535@2|Bacteria,1TR52@1239|Firmicutes,247SB@186801|Clostridia,3WK9K@541000|Ruminococcaceae	186801|Clostridia	C	Radical SAM domain protein	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,PqqD,Radical_SAM,SPASM
SX3_k127_5938535_25	1040986.ATYO01000037_gene1026	9.548e-15	79.0	COG0262@1|root,COG0262@2|Bacteria,1N1QY@1224|Proteobacteria,2UF4P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
SX3_k127_5938535_2	1499967.BAYZ01000091_gene3431	1.669e-97	323.0	COG3153@1|root,COG3153@2|Bacteria	2|Bacteria	S	transferase activity, transferring acyl groups	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Acetyltransf_1,Acetyltransf_9
SX3_k127_5938535_16	1121946.AUAX01000001_gene2382	3.798e-38	153.0	COG2249@1|root,COG2249@2|Bacteria,2GNY7@201174|Actinobacteria,4DGBC@85008|Micromonosporales	201174|Actinobacteria	S	Flavodoxin-like fold	-	-	1.6.5.2	ko:K00355	ko00130,ko01110,ko05200,ko05225,ko05418,map00130,map01110,map05200,map05225,map05418	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	Flavodoxin_2
SX3_k127_5938535_23	545693.BMQ_3978	6.565e-23	105.0	COG0491@1|root,COG0491@2|Bacteria,1TSU6@1239|Firmicutes,4HC5H@91061|Bacilli,1ZQUN@1386|Bacillus	91061|Bacilli	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SX3_k127_5938535_38	1464048.JNZS01000001_gene140	0.0005343	46.0	COG0491@1|root,COG0491@2|Bacteria,2IGRQ@201174|Actinobacteria,4DITQ@85008|Micromonosporales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SX3_k127_5938535_24	1347087.CBYO010000007_gene1323	1.65e-20	101.0	COG0500@1|root,COG0789@1|root,COG0789@2|Bacteria,COG2226@2|Bacteria,1UYTN@1239|Firmicutes,4HBY0@91061|Bacilli	91061|Bacilli	KQ	Transcriptional	-	-	-	ko:K17462	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00609	R10404	RC00003	ko00000,ko00001,ko00002,ko01000	-	-	-	MerR_1,Methyltransf_11,Methyltransf_25
SX3_k127_5938535_36	1123057.P872_21235	0.0003695	46.0	COG0508@1|root,COG0508@2|Bacteria	2|Bacteria	C	S-acyltransferase activity	-	-	2.3.1.12,2.7.11.1,3.6.4.13	ko:K00627,ko:K03310,ko:K03578,ko:K12132	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000,ko01001	2.A.25	-	-	2-oxoacid_dh,Biotin_lipoyl
SX3_k127_5938535_21	665959.HMPREF1013_05157	1.981e-29	128.0	COG0500@1|root,COG0500@2|Bacteria,1UI83@1239|Firmicutes,4HHCN@91061|Bacilli	91061|Bacilli	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
SX3_k127_5938535_37	1071085.KK033114_gene323	0.0003797	46.0	COG0500@1|root,arCOG01794@2157|Archaea,2XTKS@28890|Euryarchaeota,23TDP@183963|Halobacteria	183963|Halobacteria	Q	COG0500 SAM-dependent methyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
SX3_k127_5938535_39	911104.AEKT01000019_gene655	0.0008386	48.0	COG4635@1|root,COG4635@2|Bacteria	2|Bacteria	CH	menaquinone-dependent protoporphyrinogen oxidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_5
SX3_k127_5938535_10	1041930.Mtc_1174	4.311e-58	205.0	arCOG09456@1|root,arCOG09456@2157|Archaea,2XZTI@28890|Euryarchaeota,2NA58@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5938535_1	502025.Hoch_1221	7.848e-133	438.0	COG3385@1|root,COG3385@2|Bacteria,1NBHF@1224|Proteobacteria,43BBP@68525|delta/epsilon subdivisions,2WRX0@28221|Deltaproteobacteria,2Z20S@29|Myxococcales	28221|Deltaproteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
SX3_k127_5938535_15	1382306.JNIM01000001_gene876	1.31e-38	147.0	COG0384@1|root,COG0384@2|Bacteria,2G7RE@200795|Chloroflexi	200795|Chloroflexi	S	Phenazine biosynthesis-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
SX3_k127_5938535_12	768706.Desor_2218	1.314e-43	166.0	COG0384@1|root,COG0384@2|Bacteria,1TPPX@1239|Firmicutes,247ZD@186801|Clostridia	186801|Clostridia	S	Phenazine biosynthesis protein, PhzF family	-	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
SX3_k127_5938535_29	446470.Snas_5852	6.084e-08	63.0	2EIQA@1|root,33CFR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5938535_6	1123274.KB899416_gene2576	6.254e-68	242.0	COG0508@1|root,COG0508@2|Bacteria	2|Bacteria	C	S-acyltransferase activity	-	-	2.3.1.12,2.7.11.1,3.6.4.13	ko:K00627,ko:K03310,ko:K03578,ko:K12132	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000,ko01001	2.A.25	-	-	2-oxoacid_dh,Biotin_lipoyl
SX3_k127_5938535_28	316274.Haur_4497	5.73e-10	63.0	COG0491@1|root,COG0491@2|Bacteria,2G8K6@200795|Chloroflexi,377BH@32061|Chloroflexia	32061|Chloroflexia	S	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SX3_k127_5938535_14	1123256.KB907930_gene3482	1.536e-41	158.0	COG3189@1|root,COG3189@2|Bacteria,1RHYB@1224|Proteobacteria,1S9MZ@1236|Gammaproteobacteria,1X6ZP@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
SX3_k127_5938535_33	1226325.HMPREF1548_05722	1.187e-05	56.0	COG0454@1|root,COG0456@2|Bacteria,1UHVP@1239|Firmicutes,25E4M@186801|Clostridia,36UI8@31979|Clostridiaceae	186801|Clostridia	K	YoaP-like	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,YoaP
SX3_k127_5938535_9	926561.KB900618_gene30	5.478e-60	216.0	COG0501@1|root,COG0501@2|Bacteria,1TQV1@1239|Firmicutes,24F8J@186801|Clostridia	186801|Clostridia	O	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
SX3_k127_5938535_19	1122921.KB898187_gene4510	1.393e-32	134.0	COG2318@1|root,COG2318@2|Bacteria,1VM9M@1239|Firmicutes	1239|Firmicutes	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
SX3_k127_5938535_13	768704.Desmer_2132	9.53e-42	158.0	COG5646@1|root,COG5646@2|Bacteria,1V6QB@1239|Firmicutes,24K4J@186801|Clostridia,262M5@186807|Peptococcaceae	186801|Clostridia	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801,OmdA
SX3_k127_5938535_30	1196323.ALKF01000152_gene1013	2.23e-06	53.0	2DI3Y@1|root,301YJ@2|Bacteria,1TZM5@1239|Firmicutes,4HZ59@91061|Bacilli,273ZS@186822|Paenibacillaceae	91061|Bacilli	S	Protein of unknown function (DUF1761)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1761
SX3_k127_5938535_34	886293.Sinac_0384	0.0001803	47.0	COG3055@1|root,COG3055@2|Bacteria,2IY7R@203682|Planctomycetes	203682|Planctomycetes	E	Kelch motif	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_1
SX3_k127_5938535_22	1123242.JH636434_gene4029	6.894e-27	117.0	COG3055@1|root,COG3055@2|Bacteria,2IY7R@203682|Planctomycetes	203682|Planctomycetes	E	Kelch motif	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_1
SX3_k127_5938535_31	1236973.JCM9157_3373	7.272e-06	54.0	28PN2@1|root,2ZCAV@2|Bacteria,1V2C1@1239|Firmicutes,4HGS6@91061|Bacilli,1ZG8V@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5938535_20	1345697.M493_04940	2.6e-30	126.0	COG1247@1|root,COG1247@2|Bacteria,1VAAC@1239|Firmicutes,4HKUR@91061|Bacilli,1WG1C@129337|Geobacillus	91061|Bacilli	M	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,FR47
SX3_k127_5938535_4	1265505.ATUG01000001_gene3473	4.249e-94	318.0	COG0590@1|root,COG0590@2|Bacteria,1RHM4@1224|Proteobacteria,42SH2@68525|delta/epsilon subdivisions,2WQ49@28221|Deltaproteobacteria,2MMBZ@213118|Desulfobacterales	28221|Deltaproteobacteria	FJ	MafB19-like deaminase	-	-	-	-	-	-	-	-	-	-	-	-	MafB19-deam,dCMP_cyt_deam_1
SX3_k127_5938535_5	1173020.Cha6605_1138	1.001e-76	266.0	arCOG06802@1|root,2ZBBG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5938535_18	243164.DET1501	1.365e-32	131.0	COG0716@1|root,COG0716@2|Bacteria,2GAZ4@200795|Chloroflexi,34DME@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5938535_8	573413.Spirs_1757	1.907e-61	230.0	COG0457@1|root,COG0457@2|Bacteria,2J9HR@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5938535_35	5059.CADAFLAP00010824	0.0002277	51.0	COG0457@1|root,KOG2002@2759|Eukaryota,38B9I@33154|Opisthokonta,3NX05@4751|Fungi,3QNG0@4890|Ascomycota,20C9F@147545|Eurotiomycetes,3S340@5042|Eurotiales	4751|Fungi	P	RNA polymerase II transcription elongation factor (Ctr9)	CTR9	GO:0000082,GO:0000083,GO:0000278,GO:0000414,GO:0000416,GO:0000428,GO:0000785,GO:0000988,GO:0000989,GO:0000993,GO:0001015,GO:0001076,GO:0001098,GO:0001099,GO:0001932,GO:0001934,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0006139,GO:0006282,GO:0006351,GO:0006353,GO:0006354,GO:0006355,GO:0006356,GO:0006357,GO:0006360,GO:0006362,GO:0006366,GO:0006368,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0007049,GO:0008023,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009302,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010562,GO:0010604,GO:0010628,GO:0010638,GO:0016070,GO:0016071,GO:0016074,GO:0016591,GO:0016593,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019899,GO:0022402,GO:0030880,GO:0031056,GO:0031058,GO:0031060,GO:0031062,GO:0031123,GO:0031124,GO:0031126,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031396,GO:0031399,GO:0031401,GO:0031935,GO:0031938,GO:0031974,GO:0031981,GO:0032268,GO:0032270,GO:0032774,GO:0032784,GO:0032786,GO:0032968,GO:0032991,GO:0033043,GO:0033044,GO:0033182,GO:0034243,GO:0034470,GO:0034641,GO:0034645,GO:0034654,GO:0034660,GO:0035327,GO:0042325,GO:0042327,GO:0043144,GO:0043170,GO:0043175,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043254,GO:0043628,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044451,GO:0044464,GO:0044770,GO:0044772,GO:0044843,GO:0044877,GO:0045142,GO:0045309,GO:0045893,GO:0045935,GO:0045937,GO:0045943,GO:0045944,GO:0046483,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050794,GO:0050815,GO:0051052,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051174,GO:0051219,GO:0051246,GO:0051247,GO:0051252,GO:0051254,GO:0051569,GO:0055029,GO:0060255,GO:0060260,GO:0060968,GO:0061695,GO:0065007,GO:0070013,GO:0070063,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0090262,GO:0090304,GO:0097159,GO:0097659,GO:0098781,GO:0099122,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901407,GO:1901409,GO:1901576,GO:1902275,GO:1902494,GO:1902680,GO:1903047,GO:1903320,GO:1903506,GO:1903508,GO:1905269,GO:1990234,GO:1990269,GO:2000112,GO:2000142,GO:2000819,GO:2001020,GO:2001141,GO:2001163,GO:2001165,GO:2001166,GO:2001173,GO:2001207,GO:2001209,GO:2001252,GO:2001253,GO:2001255	-	ko:K15176	-	-	-	-	ko00000,ko03021	-	-	-	TPR_16,TPR_19,TPR_6,TPR_7,TPR_8
SX3_k127_5938535_32	391600.ABRU01000025_gene1248	7.854e-06	58.0	COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,2TR3S@28211|Alphaproteobacteria,2KFQU@204458|Caulobacterales	28211|Alphaproteobacteria	MU	type I secretion outer membrane protein, TolC family	bepC	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
SX3_k127_5938535_7	545695.TREAZ_1239	3.958e-67	249.0	COG0845@1|root,COG0845@2|Bacteria,2J7T7@203691|Spirochaetes	203691|Spirochaetes	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
SX3_k127_5938535_17	744872.Spica_1063	4.734e-38	160.0	2B46T@1|root,31WXW@2|Bacteria,2J8PP@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5938535_27	215803.DB30_0125	7.579e-11	75.0	COG2372@1|root,COG2372@2|Bacteria,1QSPC@1224|Proteobacteria,433ZQ@68525|delta/epsilon subdivisions,2X4A7@28221|Deltaproteobacteria,2YYKU@29|Myxococcales	28221|Deltaproteobacteria	S	Bacterial Ig-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_5
SX3_k127_5938535_0	744872.Spica_1065	4.89e-137	474.0	COG0841@1|root,COG0841@2|Bacteria,2J5U5@203691|Spirochaetes	203691|Spirochaetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
SX3_k127_5938535_3	665571.STHERM_c20290	1.385e-95	348.0	COG0841@1|root,COG0841@2|Bacteria,2J7G4@203691|Spirochaetes	203691|Spirochaetes	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
SX3_k127_5938535_26	1408473.JHXO01000003_gene2584	4.321e-11	74.0	2E676@1|root,330VQ@2|Bacteria,4PA7N@976|Bacteroidetes,2FZJU@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_596916_0	573413.Spirs_2889	1.693e-313	976.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,2J699@203691|Spirochaetes	203691|Spirochaetes	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
SX3_k127_596916_13	744872.Spica_1284	3.115e-90	310.0	COG2348@1|root,COG2348@2|Bacteria,2J58H@203691|Spirochaetes	203691|Spirochaetes	V	Methicillin resistance protein	femA	-	-	-	-	-	-	-	-	-	-	-	FemAB
SX3_k127_596916_14	562970.Btus_1096	7.289e-87	306.0	COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,4HBJ6@91061|Bacilli,278QW@186823|Alicyclobacillaceae	91061|Bacilli	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	GO:0002097,GO:0002098,GO:0002143,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
SX3_k127_596916_31	203119.Cthe_0738	1.273e-14	76.0	COG2608@1|root,COG2608@2|Bacteria,1VERB@1239|Firmicutes,2587I@186801|Clostridia,3WM4Z@541000|Ruminococcaceae	186801|Clostridia	C	TIGRFAM copper ion binding protein	-	-	-	ko:K07213	ko04978,map04978	-	-	-	ko00000,ko00001	-	-	-	HMA
SX3_k127_596916_18	720554.Clocl_2211	2.931e-80	275.0	COG0745@1|root,COG0745@2|Bacteria,1U3FH@1239|Firmicutes,248BR@186801|Clostridia	186801|Clostridia	K	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
SX3_k127_596916_8	203119.Cthe_1846	8.411e-129	429.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,3WN3N@541000|Ruminococcaceae	186801|Clostridia	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
SX3_k127_596916_29	1121920.AUAU01000006_gene267	8.649e-32	132.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	arsR	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
SX3_k127_596916_16	1265505.ATUG01000002_gene1702	1.023e-80	280.0	COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42UHV@68525|delta/epsilon subdivisions,2WQCZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Predicted permease	-	-	-	-	-	-	-	-	-	-	-	-	ArsP_1
SX3_k127_596916_30	931626.Awo_c23990	1.313e-25	108.0	COG1937@1|root,COG1937@2|Bacteria,1UEF0@1239|Firmicutes,25JBQ@186801|Clostridia,25XGZ@186806|Eubacteriaceae	186801|Clostridia	S	Metal-sensitive transcriptional repressor	-	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
SX3_k127_596916_1	1304866.K413DRAFT_4364	4.605e-303	946.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,36DJE@31979|Clostridiaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copA	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
SX3_k127_596916_9	926550.CLDAP_19660	2.415e-121	408.0	COG1172@1|root,COG1172@2|Bacteria,2G6A4@200795|Chloroflexi	200795|Chloroflexi	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
SX3_k127_596916_11	926550.CLDAP_19670	1.427e-107	353.0	COG1129@1|root,COG1129@2|Bacteria,2G7M7@200795|Chloroflexi	200795|Chloroflexi	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
SX3_k127_596916_6	926550.CLDAP_19680	1.799e-146	471.0	COG1879@1|root,COG1879@2|Bacteria	2|Bacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K02058,ko:K10439	ko02010,ko02030,map02010,map02030	M00212,M00221	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
SX3_k127_596916_28	889378.Spiaf_2195	1.255e-35	139.0	2EEHS@1|root,338BM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_596916_3	1449126.JQKL01000026_gene2441	1.201e-198	629.0	COG0019@1|root,COG0019@2|Bacteria,1TPE9@1239|Firmicutes,247X7@186801|Clostridia,267WP@186813|unclassified Clostridiales	186801|Clostridia	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
SX3_k127_596916_22	868131.MSWAN_1874	4.394e-71	247.0	COG2041@1|root,arCOG00266@2157|Archaea	2157|Archaea	P	COG2041 Sulfite oxidase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB,Oxidored_molyb
SX3_k127_596916_4	289376.THEYE_A0114	2.899e-168	544.0	COG0473@1|root,COG0473@2|Bacteria,3J0JQ@40117|Nitrospirae	40117|Nitrospirae	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
SX3_k127_596916_24	443254.Marpi_1805	7.039e-49	184.0	COG1647@1|root,COG1647@2|Bacteria,2GCT5@200918|Thermotogae	200918|Thermotogae	S	Alpha/beta hydrolase family	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
SX3_k127_596916_23	1122939.ATUD01000001_gene320	1.669e-49	192.0	COG2115@1|root,COG2115@2|Bacteria,2GJCA@201174|Actinobacteria,4CS1G@84995|Rubrobacteria	84995|Rubrobacteria	G	Xylose isomerase-like TIM barrel	-	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
SX3_k127_596916_32	1123274.KB899407_gene380	3.49e-07	63.0	COG1051@1|root,COG1051@2|Bacteria,2J968@203691|Spirochaetes	203691|Spirochaetes	F	pfam nudix	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
SX3_k127_596916_12	1123274.KB899408_gene3925	8.214e-101	346.0	COG4658@1|root,COG4658@2|Bacteria,2J9NA@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the NqrB RnfD family	-	-	1.6.5.8	ko:K00347	-	-	-	-	ko00000,ko01000	-	-	-	NQR2_RnfD_RnfE
SX3_k127_596916_27	573413.Spirs_0595	1.23e-38	157.0	COG2869@1|root,COG2869@2|Bacteria,2JBGM@203691|Spirochaetes	203691|Spirochaetes	C	FMN_bind	-	-	1.6.5.8	ko:K00348	-	-	-	-	ko00000,ko01000	-	-	-	FMN_bind
SX3_k127_596916_15	573413.Spirs_0596	5.349e-83	280.0	COG1347@1|root,COG1347@2|Bacteria,2J9XG@203691|Spirochaetes	203691|Spirochaetes	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	-	-	1.6.5.8	ko:K00349	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
SX3_k127_596916_20	573413.Spirs_0597	9.482e-76	269.0	COG2209@1|root,COG2209@2|Bacteria,2JA3V@203691|Spirochaetes	203691|Spirochaetes	C	Rnf-Nqr subunit, membrane protein	-	-	1.6.5.8	ko:K00350	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
SX3_k127_596916_5	573413.Spirs_0598	5.978e-151	485.0	COG2871@1|root,COG2871@2|Bacteria,2JBKD@203691|Spirochaetes	203691|Spirochaetes	C	Oxidoreductase FAD-binding domain	-	-	1.6.5.8	ko:K00351	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
SX3_k127_596916_25	1123274.KB899408_gene3930	1.389e-47	190.0	2B4IF@1|root,31XAC@2|Bacteria,2JAGS@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_596916_21	765911.Thivi_3566	1.715e-75	261.0	28JYD@1|root,2Z9NN@2|Bacteria,1MV9T@1224|Proteobacteria,1S18H@1236|Gammaproteobacteria,1WWSD@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_596916_19	1232410.KI421421_gene3507	8.701e-76	271.0	COG1227@1|root,COG4109@1|root,COG1227@2|Bacteria,COG4109@2|Bacteria,1P9JN@1224|Proteobacteria,42N0W@68525|delta/epsilon subdivisions,2WK0Q@28221|Deltaproteobacteria,43U3K@69541|Desulfuromonadales	28221|Deltaproteobacteria	CK	DHHA2	ppaC	-	3.6.1.1	ko:K15986	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	CBS,DHH,DHHA2,DRTGG
SX3_k127_596916_7	1195236.CTER_2031	9.067e-135	452.0	COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,24G9G@186801|Clostridia	186801|Clostridia	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
SX3_k127_596916_10	1094508.Tsac_1171	5.06e-108	358.0	COG0330@1|root,COG0330@2|Bacteria,1TPXU@1239|Firmicutes,248MP@186801|Clostridia,42F7F@68295|Thermoanaerobacterales	186801|Clostridia	O	SMART band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
SX3_k127_596916_26	667014.Thein_1317	2.635e-40	160.0	COG1051@1|root,COG1051@2|Bacteria,2GI88@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	F	NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
SX3_k127_596916_17	335543.Sfum_0347	1.233e-80	278.0	COG0177@1|root,COG0177@2|Bacteria,1RAK3@1224|Proteobacteria,42M4V@68525|delta/epsilon subdivisions,2WPRX@28221|Deltaproteobacteria,2MQMZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Protein of unknown function (DUF2400)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2400
SX3_k127_596916_2	573413.Spirs_2147	1.515e-209	662.0	COG0525@1|root,COG0525@2|Bacteria,2J659@203691|Spirochaetes	203691|Spirochaetes	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
SX3_k127_5997486_4	1173020.Cha6605_1854	2.058e-41	172.0	COG0210@1|root,COG0457@1|root,COG1074@1|root,COG0210@2|Bacteria,COG0457@2|Bacteria,COG1074@2|Bacteria	2|Bacteria	L	ATP-dependent DNA helicase activity	recB	-	3.4.21.88,3.6.4.12	ko:K01356,ko:K03657,ko:K16898,ko:K19676	ko03420,ko03430,map03420,map03430	M00729	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03036,ko03400	-	-	-	DUF3799,HSDR_N_2,PDDEXK_1,Peptidase_S24,UvrD-helicase,UvrD_C
SX3_k127_5997486_0	1321778.HMPREF1982_01422	4.422e-83	284.0	COG0596@1|root,COG0596@2|Bacteria,1U3PB@1239|Firmicutes,24DR6@186801|Clostridia	186801|Clostridia	S	Hydrolase, alpha beta domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
SX3_k127_5997486_6	572478.Vdis_1870	0.0006594	52.0	COG2407@1|root,arCOG01772@2157|Archaea,2XQIZ@28889|Crenarchaeota	28889|Crenarchaeota	G	L-fucose isomerase and related	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5997486_3	697281.Mahau_1339	1.076e-64	235.0	COG0407@1|root,COG0407@2|Bacteria,1V4YU@1239|Firmicutes,24FCZ@186801|Clostridia,42HY1@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
SX3_k127_5997486_5	1459636.NTE_00254	7.252e-09	65.0	COG4113@1|root,arCOG00727@2157|Archaea	2157|Archaea	S	PilT protein domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PIN
SX3_k127_5997486_1	177437.HRM2_43480	1.123e-79	289.0	COG0407@1|root,COG0407@2|Bacteria,1P737@1224|Proteobacteria,4328N@68525|delta/epsilon subdivisions,2WYF5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5997486_2	335543.Sfum_0558	8.944e-66	234.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1PFB4@1224|Proteobacteria,439XG@68525|delta/epsilon subdivisions,2WYP5@28221|Deltaproteobacteria,2MSBM@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
SX3_k127_6038131_43	1304865.JAGF01000001_gene1440	0.0002373	50.0	COG1669@1|root,COG1669@2|Bacteria,2GR6M@201174|Actinobacteria	201174|Actinobacteria	K	Nucleotidyltransferase domain	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	HTH_3,HTH_31,NTP_transf_2
SX3_k127_6038131_12	889378.Spiaf_1749	8.631e-121	396.0	COG2334@1|root,COG2334@2|Bacteria,2J9JA@203691|Spirochaetes	203691|Spirochaetes	S	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response	srkA	-	-	-	-	-	-	-	-	-	-	-	APH
SX3_k127_6038131_31	349161.Dred_1283	3.119e-35	149.0	COG1573@1|root,COG1573@2|Bacteria,1UY78@1239|Firmicutes,24FDP@186801|Clostridia,2629G@186807|Peptococcaceae	186801|Clostridia	L	DNA metabolism protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4130
SX3_k127_6038131_8	331678.Cphamn1_0347	3.852e-138	452.0	COG4277@1|root,COG4277@2|Bacteria,1FEJ9@1090|Chlorobi	1090|Chlorobi	S	radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	HHH_3
SX3_k127_6038131_13	926692.AZYG01000096_gene1900	3.906e-120	405.0	COG1233@1|root,COG1233@2|Bacteria,1TS4A@1239|Firmicutes,249K1@186801|Clostridia	186801|Clostridia	Q	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
SX3_k127_6038131_32	573413.Spirs_3988	2.584e-28	119.0	COG1762@1|root,COG1762@2|Bacteria,2J5KE@203691|Spirochaetes	203691|Spirochaetes	G	DNA-binding protein PTS system, IIA component	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	HTH_17,PTS_EIIA_2
SX3_k127_6038131_3	945713.IALB_1270	1.198e-179	568.0	COG0057@1|root,COG0057@2|Bacteria	2|Bacteria	G	glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity	gapA	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0042866,GO:0043436,GO:0043891,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	iAPECO1_1312.APECO1_847,iPC815.YPO2157,iUTI89_1310.UTI89_C1975,ic_1306.c2184	Gp_dh_C,Gp_dh_N
SX3_k127_6038131_18	545694.TREPR_2780	1.516e-96	342.0	COG0457@1|root,COG1652@1|root,COG0457@2|Bacteria,COG1652@2|Bacteria,2J7YH@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_6038131_39	1200792.AKYF01000021_gene5329	1.358e-06	61.0	COG5492@1|root,COG5492@2|Bacteria,1V706@1239|Firmicutes,4IQ3I@91061|Bacilli	91061|Bacilli	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Big_3_2,Cadherin
SX3_k127_6038131_40	795955.AFRW01000136_gene762	1.825e-05	57.0	COG0006@1|root,COG0006@2|Bacteria,2IEHN@201174|Actinobacteria,1WAIU@1268|Micrococcaceae	201174|Actinobacteria	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
SX3_k127_6038131_20	1521187.JPIM01000001_gene834	2.15e-92	317.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	yghO	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SX3_k127_6038131_35	709797.CSIRO_2012	3.342e-15	76.0	2EIVM@1|root,33CKZ@2|Bacteria,1NG0Q@1224|Proteobacteria,2UHZ9@28211|Alphaproteobacteria,3K1BU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_6038131_17	1123279.ATUS01000004_gene3041	4.169e-110	374.0	COG0074@1|root,COG0074@2|Bacteria,1MWWN@1224|Proteobacteria,1RME7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Membrane protein FdrA	fdrA	GO:0001539,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006928,GO:0008150,GO:0009361,GO:0009987,GO:0032991,GO:0040011,GO:0042709,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588,GO:1902494	-	ko:K02381	-	-	-	-	ko00000	-	-	-	CoA_binding,Ligase_CoA
SX3_k127_6038131_9	1411123.JQNH01000001_gene742	4.128e-124	409.0	COG0074@1|root,COG0074@2|Bacteria,1MX67@1224|Proteobacteria,2U0AT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Protein of unknown function (DUF1116)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1116
SX3_k127_6038131_22	1122917.KB899661_gene959	1.269e-86	299.0	COG1744@1|root,COG1744@2|Bacteria,1TPEU@1239|Firmicutes,4HF7R@91061|Bacilli,26QEK@186822|Paenibacillaceae	91061|Bacilli	S	membrane	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
SX3_k127_6038131_23	891968.Anamo_2053	1.073e-73	262.0	COG1079@1|root,COG1079@2|Bacteria,3TAFP@508458|Synergistetes	508458|Synergistetes	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
SX3_k127_6038131_26	580340.Tlie_0894	4.488e-71	261.0	COG4603@1|root,COG4603@2|Bacteria,3TAAN@508458|Synergistetes	508458|Synergistetes	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
SX3_k127_6038131_15	926550.CLDAP_02200	4.662e-118	397.0	COG3845@1|root,COG3845@2|Bacteria,2G68B@200795|Chloroflexi	200795|Chloroflexi	S	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
SX3_k127_6038131_37	1156844.KB891798_gene6183	6.485e-10	70.0	2DBAX@1|root,2Z84Q@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2877)	yahE	-	-	-	-	-	-	-	-	-	-	-	DUF2877
SX3_k127_6038131_24	545694.TREPR_2780	3.349e-72	270.0	COG0457@1|root,COG1652@1|root,COG0457@2|Bacteria,COG1652@2|Bacteria,2J7YH@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_6038131_10	521011.Mpal_0423	7.817e-124	424.0	COG3391@1|root,arCOG02516@1|root,arCOG02516@2157|Archaea,arCOG03563@2157|Archaea,2Y7Y4@28890|Euryarchaeota,2NBN4@224756|Methanomicrobia	2157|Archaea	S	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,HemolysinCabind,Kelch_4,NHL,PKD
SX3_k127_6038131_30	573413.Spirs_1216	3.983e-39	150.0	COG1472@1|root,COG1472@2|Bacteria,2J9XZ@203691|Spirochaetes	203691|Spirochaetes	G	hydrolase, family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
SX3_k127_6038131_36	573413.Spirs_1216	1.112e-11	69.0	COG1472@1|root,COG1472@2|Bacteria,2J9XZ@203691|Spirochaetes	203691|Spirochaetes	G	hydrolase, family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
SX3_k127_6038131_25	665571.STHERM_c06190	1.029e-71	248.0	COG2186@1|root,COG2186@2|Bacteria,2J7RF@203691|Spirochaetes	203691|Spirochaetes	K	FCD	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
SX3_k127_6038131_7	665571.STHERM_c06180	1.117e-138	460.0	COG0673@1|root,COG0673@2|Bacteria,2J71R@203691|Spirochaetes	203691|Spirochaetes	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX3_k127_6038131_2	665571.STHERM_c06170	4.789e-202	640.0	COG3333@1|root,COG3333@2|Bacteria,2J70X@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
SX3_k127_6038131_41	1236902.ANAS01000022_gene137	8.546e-05	51.0	2BKBV@1|root,32ESB@2|Bacteria	2|Bacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	ko:K07794	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctB
SX3_k127_6038131_6	665571.STHERM_c06150	4.142e-148	486.0	COG3181@1|root,COG3181@2|Bacteria,2J7TJ@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
SX3_k127_6038131_5	665571.STHERM_c06140	1.538e-154	496.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	-	ko:K18829	-	-	-	-	ko00000,ko02048	-	-	-	Creatinase_N,Peptidase_M24
SX3_k127_6038131_16	688269.Theth_1004	1.845e-111	370.0	COG1638@1|root,COG1638@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	-	-	-	-	-	-	-	-	-	DctP
SX3_k127_6038131_21	665571.STHERM_c04220	3.911e-90	304.0	COG1028@1|root,COG1028@2|Bacteria,2JA6X@203691|Spirochaetes	203691|Spirochaetes	C	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SX3_k127_6038131_19	1009370.ALO_11174	5.152e-95	317.0	COG1028@1|root,COG1028@2|Bacteria,1U9MA@1239|Firmicutes,4H7KS@909932|Negativicutes	909932|Negativicutes	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
SX3_k127_6038131_4	1009370.ALO_11179	9.251e-172	548.0	COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,4H1VX@909932|Negativicutes	909932|Negativicutes	G	transporter, DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
SX3_k127_6038131_29	1009370.ALO_11184	2.014e-44	169.0	COG3090@1|root,COG3090@2|Bacteria,1VGHS@1239|Firmicutes	1239|Firmicutes	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
SX3_k127_6038131_11	515635.Dtur_1774	2.75e-121	398.0	COG1638@1|root,COG1638@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	-	-	-	-	-	-	-	-	-	DctP
SX3_k127_6038131_27	665571.STHERM_c04230	8.12e-68	238.0	COG1802@1|root,COG1802@2|Bacteria,2J8MW@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, gntR family	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
SX3_k127_6038131_28	278957.ABEA03000197_gene430	4.076e-57	209.0	COG1082@1|root,COG1082@2|Bacteria,46XIH@74201|Verrucomicrobia,3K8KZ@414999|Opitutae	414999|Opitutae	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SX3_k127_6038131_38	589865.DaAHT2_1001	1.679e-07	63.0	COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,42NJU@68525|delta/epsilon subdivisions,2WJP4@28221|Deltaproteobacteria,2MMZS@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
SX3_k127_6038131_42	95619.PM1_0206485	0.0001369	51.0	COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,1RRXR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ATPase, AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
SX3_k127_6038131_33	671143.DAMO_0082	6.793e-22	104.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
SX3_k127_6038131_14	639282.DEFDS_2021	7.483e-120	397.0	COG1373@1|root,COG1373@2|Bacteria,2GFZK@200930|Deferribacteres	200930|Deferribacteres	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
SX3_k127_6038131_1	1499967.BAYZ01000032_gene1132	3.479e-248	800.0	COG4953@1|root,COG4953@2|Bacteria	2|Bacteria	M	penicillin binding	pbpC	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
SX3_k127_6038131_0	1499967.BAYZ01000032_gene1131	0.0	1556.0	COG2373@1|root,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1,Thiol-ester_cl
SX3_k127_6038131_34	665956.HMPREF1032_00837	1.763e-21	100.0	COG0407@1|root,COG0407@2|Bacteria,1V5JE@1239|Firmicutes,24E5A@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_6049296_0	1034807.FBFL15_2654	1.419e-107	360.0	COG1373@1|root,COG1373@2|Bacteria,4NHQG@976|Bacteroidetes,1I2E3@117743|Flavobacteriia	976|Bacteroidetes	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
SX3_k127_6049296_1	1123242.JH636437_gene6003	5.502e-31	124.0	COG0553@1|root,COG0553@2|Bacteria,2IX46@203682|Planctomycetes	203682|Planctomycetes	KL	helicase superfamily c-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N,SWIM
SX3_k127_6049296_3	472759.Nhal_1487	1.045e-05	51.0	COG4118@1|root,COG4118@2|Bacteria,1PBET@1224|Proteobacteria,1SURJ@1236|Gammaproteobacteria,1X1KC@135613|Chromatiales	135613|Chromatiales	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
SX3_k127_6066779_4	545695.TREAZ_2760	1.518e-109	359.0	28MXM@1|root,2Z8AT@2|Bacteria,2JBFX@203691|Spirochaetes	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_6066779_7	744872.Spica_2856	1.805e-78	273.0	COG4939@1|root,COG4939@2|Bacteria,2J7W0@203691|Spirochaetes	203691|Spirochaetes	S	FMN-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_6066779_2	1499967.BAYZ01000118_gene3284	3.458e-140	453.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	-	-	1.1.1.103,1.1.1.14	ko:K00008,ko:K00060	ko00040,ko00051,ko00260,ko01100,map00040,map00051,map00260,map01100	M00014	R00875,R01465,R01896	RC00085,RC00102,RC00525	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
SX3_k127_6066779_0	1499967.BAYZ01000109_gene2986	9.362e-235	736.0	COG1070@1|root,COG1070@2|Bacteria	2|Bacteria	G	xylulokinase activity	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
SX3_k127_6066779_16	1499967.BAYZ01000158_gene476	2.072e-05	49.0	COG1979@1|root,COG1979@2|Bacteria,2NQR1@2323|unclassified Bacteria	2|Bacteria	C	Iron-containing alcohol dehydrogenase	-	-	-	ko:K00100,ko:K19955	ko00650,ko01120,map00650,map01120	-	R03544,R03545	RC00087	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
SX3_k127_6066779_1	1195236.CTER_1615	6.41e-165	524.0	COG3386@1|root,COG3386@2|Bacteria,1V0DH@1239|Firmicutes,24CIJ@186801|Clostridia	186801|Clostridia	G	SMP-30/Gluconolaconase/LRE-like region	-	-	-	-	-	-	-	-	-	-	-	-	SGL
SX3_k127_6066779_14	641107.CDLVIII_0782	1.366e-06	59.0	COG1082@1|root,COG1082@2|Bacteria,1U81K@1239|Firmicutes,2492P@186801|Clostridia,36EQ6@31979|Clostridiaceae	186801|Clostridia	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SX3_k127_6066779_3	997884.HMPREF1068_02686	8.939e-121	400.0	COG1520@1|root,COG4225@1|root,COG1520@2|Bacteria,COG4225@2|Bacteria,4NM00@976|Bacteroidetes,2FR1A@200643|Bacteroidia,4ANP9@815|Bacteroidaceae	976|Bacteroidetes	S	unsaturated rhamnogalacturonyl hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Arylsulfotrans,Glyco_hydro_88,PQQ_2
SX3_k127_6066779_13	1382306.JNIM01000001_gene3566	1.623e-42	162.0	COG0521@1|root,COG0521@2|Bacteria,2G7HV@200795|Chloroflexi	200795|Chloroflexi	H	Probable molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
SX3_k127_6066779_10	1121918.ARWE01000001_gene2148	1.848e-52	192.0	COG2258@1|root,COG2258@2|Bacteria	2|Bacteria	C	MOSC domain	mog	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MOSC,MoCF_biosynth
SX3_k127_6066779_12	266117.Rxyl_1981	3.623e-48	178.0	COG0315@1|root,COG0315@2|Bacteria,2IHR6@201174|Actinobacteria,4CSG6@84995|Rubrobacteria	84995|Rubrobacteria	H	MoaC family	-	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
SX3_k127_6066779_9	1408322.JHYK01000003_gene1051	5.125e-53	196.0	COG2896@1|root,COG2896@2|Bacteria,1TP89@1239|Firmicutes,247PP@186801|Clostridia,27IWC@186928|unclassified Lachnospiraceae	186801|Clostridia	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
SX3_k127_6066779_6	1408473.JHXO01000010_gene3618	3.068e-79	279.0	COG0303@1|root,COG0303@2|Bacteria,4NDYD@976|Bacteroidetes	976|Bacteroidetes	H	Molybdenum cofactor synthesis domain	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
SX3_k127_6066779_11	439235.Dalk_1502	9.422e-49	187.0	COG3842@1|root,COG3842@2|Bacteria,1QWPH@1224|Proteobacteria,43E0E@68525|delta/epsilon subdivisions,2X75F@28221|Deltaproteobacteria,2MPKB@213118|Desulfobacterales	28221|Deltaproteobacteria	P	ABC transporter	-	-	3.6.3.55	ko:K06857	ko02010,map02010	M00186	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	ABC_tran
SX3_k127_6066779_8	1499967.BAYZ01000161_gene395	1.331e-58	211.0	COG4662@1|root,COG4662@2|Bacteria,2NPF5@2323|unclassified Bacteria	2|Bacteria	H	Binding-protein-dependent transport system inner membrane component	tupB	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
SX3_k127_6066779_5	706587.Desti_0068	1.22e-89	305.0	COG2998@1|root,COG2998@2|Bacteria,1MVSF@1224|Proteobacteria,42NK5@68525|delta/epsilon subdivisions,2WM49@28221|Deltaproteobacteria,2MQA9@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Bacterial extracellular solute-binding protein	-	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
SX3_k127_6066779_15	717606.PaecuDRAFT_1404	8.394e-06	56.0	COG1763@1|root,COG1763@2|Bacteria,1VFA0@1239|Firmicutes,4HNMQ@91061|Bacilli,26YYH@186822|Paenibacillaceae	91061|Bacilli	H	molybdopterin-guanine dinucleotide biosynthesis protein	mobB	-	-	ko:K03753	-	-	-	-	ko00000	-	-	-	MobB
SX3_k127_6090169_5	573413.Spirs_1458	5.499e-74	276.0	COG4953@1|root,COG4953@2|Bacteria,2J606@203691|Spirochaetes	203691|Spirochaetes	M	Penicillin-binding Protein	-	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
SX3_k127_6090169_10	1150600.ADIARSV_0295	8.897e-38	159.0	COG0697@1|root,COG0697@2|Bacteria,4NGJR@976|Bacteroidetes,1IPGU@117747|Sphingobacteriia	976|Bacteroidetes	EG	PFAM EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SX3_k127_6090169_0	744872.Spica_0922	8.08e-289	906.0	COG0013@1|root,COG0013@2|Bacteria,2J5G2@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
SX3_k127_6090169_6	1131269.AQVV01000024_gene2368	3.036e-65	256.0	COG4166@1|root,COG4166@2|Bacteria	2|Bacteria	E	transmembrane transport	oppA	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006810,GO:0006811,GO:0006820,GO:0006857,GO:0006869,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010876,GO:0015711,GO:0015718,GO:0015721,GO:0015833,GO:0015849,GO:0015850,GO:0030288,GO:0030313,GO:0031975,GO:0033036,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0042939,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0061077,GO:0071702,GO:0071705,GO:1900750	-	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	iECABU_c1320.ECABU_c15240,iECNA114_1301.ECNA114_1414,iECSF_1327.ECSF_1224,iNRG857_1313.NRG857_06385,iUMNK88_1353.UMNK88_1667	SBP_bac_5
SX3_k127_6090169_3	316274.Haur_1430	6.308e-98	360.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,2G699@200795|Chloroflexi,3764S@32061|Chloroflexia	200795|Chloroflexi	T	PFAM adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc
SX3_k127_6090169_4	1125701.HMPREF1221_00377	2.171e-94	321.0	COG0820@1|root,COG0820@2|Bacteria,2J5C3@203691|Spirochaetes	203691|Spirochaetes	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
SX3_k127_6090169_2	744872.Spica_1434	7.39e-139	454.0	COG0457@1|root,COG0457@2|Bacteria,2J5I5@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
SX3_k127_6090169_11	1123274.KB899429_gene2869	6.662e-32	128.0	291RI@1|root,2ZPBI@2|Bacteria,2J8IP@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_6090169_8	1480694.DC28_11895	5.314e-55	199.0	COG0131@1|root,COG0131@2|Bacteria,2J6ZQ@203691|Spirochaetes	203691|Spirochaetes	E	imidazoleglycerol-phosphate dehydratase	hisB	-	3.1.3.15,4.2.1.19	ko:K01089,ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013,R03457	RC00017,RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	Hydrolase_like,IGPD
SX3_k127_6090169_1	1123274.KB899424_gene2975	7.209e-286	887.0	COG0464@1|root,COG0464@2|Bacteria,2J66D@203691|Spirochaetes	203691|Spirochaetes	O	ATPase (AAA	-	-	-	-	-	-	-	-	-	-	-	-	AAA
SX3_k127_6090169_15	472759.Nhal_0243	8.558e-05	47.0	2E3EN@1|root,32YDN@2|Bacteria,1N7N7@1224|Proteobacteria,1SCSD@1236|Gammaproteobacteria,1WZ7N@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF4160)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4160
SX3_k127_6090169_9	1123274.KB899424_gene2987	2.688e-51	209.0	COG0457@1|root,COG1474@1|root,COG0457@2|Bacteria,COG1474@2|Bacteria,2J6N3@203691|Spirochaetes	203691|Spirochaetes	LO	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_6090169_12	573413.Spirs_2347	8.173e-30	126.0	COG2172@1|root,COG2172@2|Bacteria	2|Bacteria	T	sigma factor antagonist activity	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2
SX3_k127_6090169_7	665571.STHERM_c17580	4.818e-63	220.0	COG0778@1|root,COG0778@2|Bacteria,2J8VG@203691|Spirochaetes	203691|Spirochaetes	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
SX3_k127_6149535_6	555079.Toce_1870	4.412e-59	218.0	COG2017@1|root,COG2017@2|Bacteria,1TS8H@1239|Firmicutes,24D4Y@186801|Clostridia,42I5Y@68295|Thermoanaerobacterales	186801|Clostridia	G	Domain of unknown function (DUF4432)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4432
SX3_k127_6149535_4	889378.Spiaf_1935	1.632e-112	384.0	COG0815@1|root,COG0815@2|Bacteria,2J5UW@203691|Spirochaetes	203691|Spirochaetes	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
SX3_k127_6149535_11	326427.Cagg_1666	6.394e-21	100.0	COG0296@1|root,COG0296@2|Bacteria,2G9SJ@200795|Chloroflexi,377QN@32061|Chloroflexia	32061|Chloroflexia	G	PFAM glycoside hydrolase family 13 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM,CBM_48
SX3_k127_6149535_2	373994.Riv7116_6621	8.325e-114	400.0	COG2366@1|root,COG2366@2|Bacteria,1G4M5@1117|Cyanobacteria,1HU4F@1161|Nostocales	1117|Cyanobacteria	S	penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
SX3_k127_6149535_10	1123401.JHYQ01000026_gene3238	1.703e-26	112.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,1SCKA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	RNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
SX3_k127_6149535_0	1480694.DC28_03485	1.08e-189	611.0	COG0137@1|root,COG0137@2|Bacteria,2J5QQ@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
SX3_k127_6149535_1	665571.STHERM_c20050	1.008e-120	407.0	COG4992@1|root,COG4992@2|Bacteria,2J5X2@203691|Spirochaetes	203691|Spirochaetes	E	PFAM aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SX3_k127_6149535_5	665571.STHERM_c20040	9.859e-64	228.0	COG0548@1|root,COG0548@2|Bacteria,2J6RN@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
SX3_k127_6149535_3	665571.STHERM_c20030	4.225e-113	376.0	COG0002@1|root,COG0002@2|Bacteria,2J637@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
SX3_k127_6149535_9	1307761.L21SP2_3025	7.972e-30	134.0	COG1438@1|root,COG1438@2|Bacteria,2J7NJ@203691|Spirochaetes	203691|Spirochaetes	K	Regulates arginine biosynthesis genes	argR	-	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
SX3_k127_6149535_7	1449126.JQKL01000037_gene2034	1.318e-49	183.0	COG1611@1|root,COG1611@2|Bacteria,1UKED@1239|Firmicutes,24DSN@186801|Clostridia	186801|Clostridia	L	Belongs to the LOG family	yvdD	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
SX3_k127_6149535_8	545695.TREAZ_0310	5.098e-44	164.0	COG1801@1|root,COG1801@2|Bacteria,2J5GQ@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
SX3_k127_6191744_1	156889.Mmc1_1083	1.001e-30	124.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2TRMJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	ATP-dependent helicase	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
SX3_k127_6191744_2	886293.Sinac_6278	1.485e-27	128.0	COG4219@1|root,COG4219@2|Bacteria,2J205@203682|Planctomycetes	203682|Planctomycetes	KT	BlaR1 peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56,Thioredoxin_7
SX3_k127_6191744_0	886293.Sinac_6279	3.827e-33	132.0	COG3682@1|root,COG3682@2|Bacteria,2J0QT@203682|Planctomycetes	203682|Planctomycetes	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
SX3_k127_6198519_2	180332.JTGN01000002_gene5723	9.289e-93	310.0	COG1402@1|root,COG1402@2|Bacteria,1V0N8@1239|Firmicutes,24BWG@186801|Clostridia	186801|Clostridia	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470,ko:K22232	ko00330,ko00562,map00330,map00562	-	R01884,R11771	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
SX3_k127_6198519_11	469383.Cwoe_0193	7.245e-08	59.0	COG0662@1|root,COG0662@2|Bacteria,2GXJK@201174|Actinobacteria,4CT2T@84995|Rubrobacteria	84995|Rubrobacteria	G	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SX3_k127_6198519_1	1499967.BAYZ01000041_gene2362	4.613e-101	337.0	COG1028@1|root,COG1028@2|Bacteria	1499967.BAYZ01000041_gene2362|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_6198519_0	868595.Desca_2486	1.656e-150	496.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,2604P@186807|Peptococcaceae	186801|Clostridia	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
SX3_k127_6198519_4	1408254.T458_26080	2.385e-69	248.0	COG2055@1|root,COG2055@2|Bacteria,1TR0Z@1239|Firmicutes,4HB6X@91061|Bacilli,26WJP@186822|Paenibacillaceae	91061|Bacilli	C	Malate/L-lactate dehydrogenase	-	-	1.1.1.350	ko:K00073	ko00230,ko01120,map00230,map01120	-	R02935,R02936	RC00169	ko00000,ko00001,ko01000	-	-	-	Ldh_2
SX3_k127_6198519_6	706587.Desti_3247	5.075e-50	187.0	COG0684@1|root,COG0684@2|Bacteria,1MW9P@1224|Proteobacteria,42VU3@68525|delta/epsilon subdivisions,2WRWJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Aldolase/RraA	-	-	4.1.3.17	ko:K10218	ko00362,ko00660,ko01120,map00362,map00660,map01120	-	R00008,R00350	RC00067,RC00502,RC01205	ko00000,ko00001,ko01000	-	-	-	RraA-like
SX3_k127_6198519_8	1515746.HR45_14160	3.674e-26	116.0	COG1802@1|root,COG1802@2|Bacteria,1NDRT@1224|Proteobacteria,1RYXQ@1236|Gammaproteobacteria,2Q9X5@267890|Shewanellaceae	1236|Gammaproteobacteria	K	PFAM regulatory protein GntR HTH	prpR	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
SX3_k127_6198519_12	1051632.TPY_2324	6.379e-06	50.0	COG3039@1|root,COG3039@2|Bacteria,1TRBK@1239|Firmicutes,24DZ0@186801|Clostridia	186801|Clostridia	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
SX3_k127_6198519_9	665571.STHERM_c20700	4.137e-23	106.0	COG3039@1|root,COG3039@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
SX3_k127_6198519_3	1382356.JQMP01000001_gene1176	6.719e-75	265.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
SX3_k127_6198519_10	696369.KI912183_gene316	1.101e-09	65.0	COG1977@1|root,COG1977@2|Bacteria,1VIUV@1239|Firmicutes,24RKW@186801|Clostridia,2634S@186807|Peptococcaceae	186801|Clostridia	H	Mut7-C ubiquitin	-	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
SX3_k127_6198519_5	351160.RRC447	5.32e-68	239.0	COG0476@1|root,arCOG01676@2157|Archaea,2XTYV@28890|Euryarchaeota,2N9IZ@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM UBA THIF-type NAD FAD binding protein	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
SX3_k127_6198519_7	1395513.P343_18295	5.743e-38	144.0	COG0454@1|root,COG0456@2|Bacteria,1V1RG@1239|Firmicutes,4HFN7@91061|Bacilli	91061|Bacilli	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	paiA	GO:0003674,GO:0003824,GO:0004145,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008080,GO:0008150,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0043937,GO:0043939,GO:0044424,GO:0044464,GO:0048519,GO:0050789,GO:0050793,GO:0051093,GO:0065007	2.3.1.57	ko:K22441	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10
SX3_k127_6200933_5	1499967.BAYZ01000190_gene3853	1.925e-77	265.0	COG0407@1|root,COG0407@2|Bacteria,2NPXG@2323|unclassified Bacteria	2|Bacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
SX3_k127_6200933_4	1121440.AUMA01000003_gene3071	6.205e-84	288.0	COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,42PTI@68525|delta/epsilon subdivisions,2WIWT@28221|Deltaproteobacteria,2M93E@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
SX3_k127_6200933_0	1121405.dsmv_0287	2.321e-243	775.0	COG1042@1|root,COG1042@2|Bacteria,1NU6B@1224|Proteobacteria,42NAU@68525|delta/epsilon subdivisions,2WJHX@28221|Deltaproteobacteria,2MIMR@213118|Desulfobacterales	2|Bacteria	C	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
SX3_k127_6200933_1	1499967.BAYZ01000032_gene1133	8.395e-211	662.0	COG0205@1|root,COG0205@2|Bacteria,2NP3J@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfkA	-	2.7.1.11,2.7.1.90	ko:K00850,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
SX3_k127_6200933_8	667014.Thein_1165	2.772e-26	119.0	COG0778@1|root,COG0778@2|Bacteria,2GHTQ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SX3_k127_6200933_6	717606.PaecuDRAFT_2136	5.765e-65	255.0	COG1520@1|root,COG3210@1|root,COG4412@1|root,COG5276@1|root,COG5492@1|root,COG1520@2|Bacteria,COG3210@2|Bacteria,COG4412@2|Bacteria,COG5276@2|Bacteria,COG5492@2|Bacteria,1TR9M@1239|Firmicutes,4HEPP@91061|Bacilli,26T62@186822|Paenibacillaceae	91061|Bacilli	U	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Cadherin-like,Cohesin,Invasin_D3,SLH
SX3_k127_6200933_2	545694.TREPR_2780	5.461e-124	439.0	COG0457@1|root,COG1652@1|root,COG0457@2|Bacteria,COG1652@2|Bacteria,2J7YH@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_6200933_3	545694.TREPR_0043	3.933e-115	397.0	COG0457@1|root,COG0457@2|Bacteria,2J74T@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_6200933_9	665571.STHERM_c20730	7.524e-08	65.0	2FG3W@1|root,3480E@2|Bacteria,2JAXH@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_6207900_12	1089553.Tph_c24780	3.075e-104	367.0	COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,42F3G@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
SX3_k127_6207900_11	158190.SpiGrapes_1081	1.309e-111	390.0	COG1033@1|root,COG1033@2|Bacteria,2J636@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG1033 exporter of the RND superfamily protein	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
SX3_k127_6207900_17	1535287.JP74_01095	6.64e-67	236.0	COG1215@1|root,COG1215@2|Bacteria,1RE2E@1224|Proteobacteria,2U721@28211|Alphaproteobacteria,3N7KK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SX3_k127_6207900_18	1123508.JH636439_gene995	2.876e-65	241.0	COG1820@1|root,COG1820@2|Bacteria,2IYHR@203682|Planctomycetes	203682|Planctomycetes	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	-	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
SX3_k127_6207900_23	573413.Spirs_0552	8.967e-47	176.0	COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,2J8E5@203691|Spirochaetes	203691|Spirochaetes	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
SX3_k127_6207900_19	545695.TREAZ_3159	5.015e-65	231.0	COG0120@1|root,COG0120@2|Bacteria,2J575@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
SX3_k127_6207900_3	211165.AJLN01000017_gene2137	4.469e-209	668.0	COG2217@1|root,COG2217@2|Bacteria,1G11M@1117|Cyanobacteria,1JJQ5@1189|Stigonemataceae	1117|Cyanobacteria	P	E1-E2 ATPase	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,HMA,Hydrolase
SX3_k127_6207900_20	234267.Acid_7863	9.742e-65	230.0	COG0179@1|root,COG0179@2|Bacteria,3Y30T@57723|Acidobacteria	57723|Acidobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
SX3_k127_6207900_9	929562.Emtol_1243	3.07e-127	419.0	COG2942@1|root,COG2942@2|Bacteria,4NHTQ@976|Bacteroidetes,47KVQ@768503|Cytophagia	976|Bacteroidetes	G	N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)	-	-	5.1.3.11	ko:K16213	-	-	R01445,R10810	RC00289	ko00000,ko01000	-	-	-	GlcNAc_2-epim
SX3_k127_6207900_2	889378.Spiaf_0670	4.093e-224	704.0	COG0148@1|root,COG0148@2|Bacteria,2J59Y@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
SX3_k127_6207900_24	744872.Spica_0548	8.018e-46	177.0	COG0454@1|root,COG0456@2|Bacteria,2J74W@203691|Spirochaetes	203691|Spirochaetes	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,UPF0158
SX3_k127_6207900_14	864069.MicloDRAFT_00041850	2.205e-81	280.0	COG0561@1|root,COG0561@2|Bacteria,1R4WX@1224|Proteobacteria,2TSDR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	hydrolases of the HAD superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
SX3_k127_6207900_16	744872.Spica_2540	1.941e-68	244.0	COG0204@1|root,COG0204@2|Bacteria,2J6GX@203691|Spirochaetes	203691|Spirochaetes	I	Phosphate acyltransferases	-	-	2.3.1.15	ko:K00631	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
SX3_k127_6207900_1	573413.Spirs_3744	8.414e-252	788.0	COG0747@1|root,COG0747@2|Bacteria	2|Bacteria	E	dipeptide transport	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
SX3_k127_6207900_5	573413.Spirs_3743	2.1e-156	499.0	COG0601@1|root,COG0601@2|Bacteria	2|Bacteria	P	nitrogen compound transport	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
SX3_k127_6207900_6	1123274.KB899410_gene3557	2.264e-145	467.0	COG1173@1|root,COG1173@2|Bacteria	2|Bacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	dppC	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
SX3_k127_6207900_4	573413.Spirs_3741	1.312e-163	534.0	COG0444@1|root,COG0444@2|Bacteria,2J62R@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
SX3_k127_6207900_10	1499967.BAYZ01000006_gene5458	1.036e-121	402.0	COG4608@1|root,COG4608@2|Bacteria	2|Bacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
SX3_k127_6207900_8	234267.Acid_2122	3.54e-134	448.0	COG0524@1|root,COG0524@2|Bacteria,3Y6VV@57723|Acidobacteria	57723|Acidobacteria	G	pfkB family carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
SX3_k127_6207900_22	1307761.L21SP2_2557	3.05e-51	194.0	COG0388@1|root,COG0388@2|Bacteria	1307761.L21SP2_2557|-	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_6207900_7	368407.Memar_0764	2.347e-136	453.0	COG0475@1|root,arCOG01953@2157|Archaea,2XV77@28890|Euryarchaeota,2NATR@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
SX3_k127_6207900_29	227377.CBU_1763	7.223e-09	59.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	HTH_36
SX3_k127_6207900_21	227377.CBU_1763	2.154e-64	231.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	HTH_36
SX3_k127_6207900_26	56107.Cylst_4040	1.078e-21	95.0	COG1598@1|root,COG1598@2|Bacteria,1G7N4@1117|Cyanobacteria,1HPUK@1161|Nostocales	1117|Cyanobacteria	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
SX3_k127_6207900_13	886293.Sinac_4385	7.261e-85	292.0	COG4279@1|root,COG4279@2|Bacteria,2IYXU@203682|Planctomycetes	203682|Planctomycetes	S	SWIM zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
SX3_k127_6207900_0	886293.Sinac_4384	0.0	1043.0	COG0553@1|root,COG0553@2|Bacteria,2IXFX@203682|Planctomycetes	203682|Planctomycetes	L	COG0553 Superfamily II DNA RNA	-	-	-	-	-	-	-	-	-	-	-	-	DUF3670,Helicase_C,SNF2_N
SX3_k127_6207900_25	1480694.DC28_04880	3.255e-33	134.0	COG2402@1|root,COG2402@2|Bacteria,2J83V@203691|Spirochaetes	203691|Spirochaetes	S	PIN domain	-	-	-	ko:K07065	-	-	-	-	ko00000	-	-	-	PIN
SX3_k127_6207900_15	1454004.AW11_03844	2.164e-71	247.0	COG1483@1|root,COG1483@2|Bacteria,1MX1G@1224|Proteobacteria,2VHB3@28216|Betaproteobacteria,1KQ8Z@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF499)	-	-	-	ko:K06922	-	-	-	-	ko00000	-	-	-	DUF499
SX3_k127_6252414_1	1449126.JQKL01000038_gene967	2.076e-41	155.0	COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,1TP6C@1239|Firmicutes,24897@186801|Clostridia,267NJ@186813|unclassified Clostridiales	186801|Clostridia	C	Iron hydrogenase small subunit	-	-	1.12.1.3,1.6.5.3	ko:K00336,ko:K18332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_7,Fer4_9,NADH-G_4Fe-4S_3
SX3_k127_6252414_0	1123274.KB899408_gene3796	6.437e-246	773.0	COG0493@1|root,COG1894@1|root,COG0493@2|Bacteria,COG1894@2|Bacteria,2J5W1@203691|Spirochaetes	203691|Spirochaetes	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4_20,NADH_4Fe-4S,Pyr_redox_2,SLBB
SX3_k127_6253786_2	1232452.BAIB02000002_gene42	6.61e-115	401.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia	186801|Clostridia	G	import. Responsible for energy coupling to the transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
SX3_k127_6253786_5	2002.JOEQ01000030_gene2079	1.073e-40	171.0	COG1172@1|root,COG1172@2|Bacteria,2GM6S@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
SX3_k127_6253786_0	1487921.DP68_16700	2.878e-155	501.0	COG1902@1|root,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,24C9J@186801|Clostridia,36F9D@31979|Clostridiaceae	186801|Clostridia	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
SX3_k127_6253786_1	196367.JNFG01000039_gene7916	1.533e-122	404.0	COG0169@1|root,COG0169@2|Bacteria,1QNXY@1224|Proteobacteria,2VZFK@28216|Betaproteobacteria,1K5JT@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_6253786_3	1499967.BAYZ01000066_gene6054	4.192e-73	251.0	COG2140@1|root,COG2140@2|Bacteria	2|Bacteria	G	oxalate decarboxylase activity	-	-	5.3.1.9	ko:K06859	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Cupin_2,GPI
SX3_k127_6253786_4	1499967.BAYZ01000066_gene6053	1.33e-45	171.0	COG0111@1|root,COG0111@2|Bacteria	2|Bacteria	EH	4-phosphoerythronate dehydrogenase activity	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
SX3_k127_6276567_5	1247963.JPHU01000004_gene575	0.0001226	49.0	COG2267@1|root,COG2267@2|Bacteria,1MWDA@1224|Proteobacteria,2TSZ4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	alpha, beta	pldB	-	3.1.1.5	ko:K01048	ko00564,map00564	-	-	-	ko00000,ko00001,ko01000	-	-	-	Hydrolase_4
SX3_k127_6276567_0	398512.JQKC01000001_gene2200	3.258e-113	372.0	COG5297@1|root,COG5297@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase family 6	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Beta-lactamase,CBM60,CBM_2,Cellulase,DUF1593,PSCyt3,fn3
SX3_k127_6276567_2	573413.Spirs_2943	3.8e-71	254.0	COG1120@1|root,COG1120@2|Bacteria,2J5UM@203691|Spirochaetes	203691|Spirochaetes	HP	COGs COG1120 ABC-type cobalamin Fe3 -siderophores transport systems ATPase components	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
SX3_k127_6276567_1	1499967.BAYZ01000077_gene859	7.644e-104	348.0	COG0609@1|root,COG0609@2|Bacteria,2NP8A@2323|unclassified Bacteria	2|Bacteria	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	fecD	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
SX3_k127_6276567_3	158190.SpiGrapes_3185	2.114e-65	243.0	COG0614@1|root,COG0614@2|Bacteria,2J66K@203691|Spirochaetes	203691|Spirochaetes	P	periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
SX3_k127_6276567_4	380703.AHA_2169	9.095e-31	127.0	COG2068@1|root,COG2068@2|Bacteria,1QE5N@1224|Proteobacteria,1S3GJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Mo(VI)-molybdopterin cytosine dinucleotide biosynthetic process	ygfJ	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019538,GO:0019637,GO:0019720,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061602,GO:0070567,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902759,GO:1902760	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_3649,iB21_1397.B21_02672,iECABU_c1320.ECABU_c31580,iECBD_1354.ECBD_0860,iECB_1328.ECB_02710,iECD_1391.ECD_02710,iEcHS_1320.EcHS_A3037	NTP_transf_3
SX3_k127_630651_4	760568.Desku_1708	4.247e-89	310.0	COG4198@1|root,COG4198@2|Bacteria,1TQSW@1239|Firmicutes,249E4@186801|Clostridia,2617E@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
SX3_k127_630651_9	1499967.BAYZ01000033_gene1105	5.682e-42	162.0	COG0655@1|root,COG0655@2|Bacteria	2|Bacteria	S	NAD(P)H dehydrogenase (quinone) activity	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
SX3_k127_630651_3	640511.BC1002_6699	2.399e-117	398.0	COG1032@1|root,COG1032@2|Bacteria,1R92G@1224|Proteobacteria,2WB71@28216|Betaproteobacteria,1K09Q@119060|Burkholderiaceae	28216|Betaproteobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
SX3_k127_630651_8	880073.Calab_3513	1.386e-43	177.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	pip	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Peptidase_S9
SX3_k127_630651_10	69014.TK0480	9.74e-15	83.0	COG1418@1|root,arCOG01860@2157|Archaea,2XT54@28890|Euryarchaeota,24358@183968|Thermococci	183968|Thermococci	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
SX3_k127_630651_2	1267535.KB906767_gene917	1.498e-120	399.0	COG1915@1|root,COG1915@2|Bacteria,3Y6MM@57723|Acidobacteria	57723|Acidobacteria	S	LOR/SDH bifunctional enzyme conserved region	-	-	-	-	-	-	-	-	-	-	-	-	Saccharop_dh_N
SX3_k127_630651_1	573413.Spirs_4136	3.227e-203	644.0	COG0016@1|root,COG0016@2|Bacteria,2J63H@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
SX3_k127_630651_0	665571.STHERM_c21760	1.152e-210	668.0	COG0072@1|root,COG0072@2|Bacteria,2J63Q@203691|Spirochaetes	203691|Spirochaetes	J	Phenylalanyl-tRNA synthetase, beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B5,tRNA-synt_2d,tRNA_bind
SX3_k127_630651_5	744872.Spica_0155	6.549e-63	224.0	COG1839@1|root,COG1839@2|Bacteria,2JAAH@203691|Spirochaetes	203691|Spirochaetes	S	Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
SX3_k127_630651_7	1382359.JIAL01000001_gene240	9.432e-53	194.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
SX3_k127_630651_6	545694.TREPR_2780	6.877e-62	238.0	COG0457@1|root,COG1652@1|root,COG0457@2|Bacteria,COG1652@2|Bacteria,2J7YH@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_630676_1	1382359.JIAL01000001_gene240	1.528e-44	169.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
SX3_k127_630676_2	1382359.JIAL01000001_gene240	9.702e-12	70.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
SX3_k127_630676_0	1121918.ARWE01000001_gene10	6.516e-127	416.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,42WT2@68525|delta/epsilon subdivisions,2WR9X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
SX3_k127_6322292_0	1499967.BAYZ01000117_gene3307	1.194e-90	309.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	rbsR	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
SX3_k127_6322292_1	278957.ABEA03000005_gene4380	2.712e-20	92.0	COG0407@1|root,COG0407@2|Bacteria,46WW7@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
SX3_k127_6368032_0	547042.BACCOPRO_03195	8.994e-115	380.0	COG0407@1|root,COG0407@2|Bacteria,4NTJT@976|Bacteroidetes,2FUJS@200643|Bacteroidia,4AQYC@815|Bacteroidaceae	976|Bacteroidetes	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_6368032_2	584708.Apau_0614	1.509e-55	218.0	COG0300@1|root,COG0300@2|Bacteria,3TC5K@508458|Synergistetes	508458|Synergistetes	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
SX3_k127_6368032_1	1480694.DC28_10390	9.405e-92	316.0	COG2309@1|root,COG2309@2|Bacteria,2J7AX@203691|Spirochaetes	203691|Spirochaetes	E	Aminopeptidase	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
SX3_k127_6368032_3	483219.LILAB_06420	1.045e-20	98.0	COG4249@1|root,COG4249@2|Bacteria,1QX7K@1224|Proteobacteria,43AHW@68525|delta/epsilon subdivisions,2X5Y0@28221|Deltaproteobacteria,2Z147@29|Myxococcales	28221|Deltaproteobacteria	S	Peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_6373892_5	1158294.JOMI01000001_gene1387	6.711e-05	46.0	2A5P9@1|root,30UE4@2|Bacteria,4NZ0B@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_6373892_4	443144.GM21_2646	8.697e-06	50.0	COG1708@1|root,COG1708@2|Bacteria,1N97U@1224|Proteobacteria	1224|Proteobacteria	S	nucleotidyltransferase substrate binding protein, HI0074 family	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2,NTase_sub_bind
SX3_k127_6373892_3	398767.Glov_3593	7.159e-14	74.0	COG1708@1|root,COG1708@2|Bacteria,1N97U@1224|Proteobacteria,42TTD@68525|delta/epsilon subdivisions,2WQUK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Nucleotidyltransferase substrate binding protein like	-	-	-	-	-	-	-	-	-	-	-	-	NTase_sub_bind
SX3_k127_6373892_2	744872.Spica_2788	2.898e-82	284.0	COG1475@1|root,COG1475@2|Bacteria,2J5S6@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the ParB family	spo0J	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
SX3_k127_6373892_1	573413.Spirs_4301	5.001e-106	349.0	COG1192@1|root,COG1192@2|Bacteria,2J5VP@203691|Spirochaetes	203691|Spirochaetes	D	CobQ CobB MinD ParA nucleotide binding domain	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
SX3_k127_6373892_0	459349.CLOAM1253	2.382e-179	574.0	COG1328@1|root,COG1328@2|Bacteria,2NNQN@2323|unclassified Bacteria	2|Bacteria	F	Anaerobic ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,NRDD
SX3_k127_6413571_17	1121456.ATVA01000011_gene1532	3.864e-42	162.0	COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,1RGKE@1224|Proteobacteria,42QI9@68525|delta/epsilon subdivisions,2WIV3@28221|Deltaproteobacteria,2M9A9@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	metal-dependent phosphohydrolase HD region	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HD,Lactamase_B_2
SX3_k127_6413571_0	889378.Spiaf_2605	2.099e-278	871.0	COG1523@1|root,COG1523@2|Bacteria,2J61K@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
SX3_k127_6413571_4	1499967.BAYZ01000028_gene1254	1.874e-148	478.0	COG2055@1|root,COG2055@2|Bacteria,2NQ9A@2323|unclassified Bacteria	2|Bacteria	C	Malate/L-lactate dehydrogenase	comC	-	1.1.1.350	ko:K00073	ko00230,ko01120,map00230,map01120	-	R02935,R02936	RC00169	ko00000,ko00001,ko01000	-	-	-	Ldh_2
SX3_k127_6413571_16	604331.AUHY01000103_gene2121	1.979e-44	170.0	COG4096@1|root,COG4096@2|Bacteria	2|Bacteria	L	type I site-specific deoxyribonuclease activity	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	EcoEI_R_C,Helicase_C,ResIII
SX3_k127_6413571_26	65393.PCC7424_4139	6.493e-05	48.0	COG0732@1|root,COG0732@2|Bacteria,1GJKR@1117|Cyanobacteria,3KKD3@43988|Cyanothece	1117|Cyanobacteria	L	PFAM restriction modification system DNA specificity domain	-	-	3.1.21.3	ko:K01154	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Methylase_S
SX3_k127_6413571_18	700598.Niako_7160	1.673e-34	138.0	COG3654@1|root,COG3943@1|root,COG3654@2|Bacteria,COG3943@2|Bacteria,4NEGN@976|Bacteroidetes,1IRIW@117747|Sphingobacteriia	976|Bacteroidetes	S	Virulence protein RhuM family	-	-	-	-	-	-	-	-	-	-	-	-	Fic,Virulence_RhuM
SX3_k127_6413571_21	1122222.AXWR01000018_gene2629	4.18e-30	121.0	COG0286@1|root,COG0286@2|Bacteria,1WI3E@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	HsdM N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	HsdM_N,N6_Mtase
SX3_k127_6413571_23	1122222.AXWR01000018_gene2629	6.53e-21	94.0	COG0286@1|root,COG0286@2|Bacteria,1WI3E@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	HsdM N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	HsdM_N,N6_Mtase
SX3_k127_6413571_25	290317.Cpha266_2367	3.612e-07	55.0	COG0286@1|root,COG0286@2|Bacteria	2|Bacteria	V	site-specific DNA-methyltransferase (adenine-specific) activity	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_Mtase
SX3_k127_6413571_20	575540.Isop_2134	2.363e-31	139.0	COG1904@1|root,COG1904@2|Bacteria,2J28E@203682|Planctomycetes	203682|Planctomycetes	G	glucuronate isomerase	-	-	5.3.1.12	ko:K01812	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	-
SX3_k127_6413571_14	530564.Psta_2824	9.451e-47	181.0	COG0524@1|root,COG0524@2|Bacteria,2J3WH@203682|Planctomycetes	203682|Planctomycetes	H	PFAM PfkB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
SX3_k127_6413571_7	243274.THEMA_07915	4.09e-96	341.0	COG4638@1|root,COG4638@2|Bacteria,2GCAJ@200918|Thermotogae	200918|Thermotogae	P	Rieske (2Fe-2S) domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
SX3_k127_6413571_5	760011.Spico_1261	1.145e-126	424.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	5.1.3.22,5.3.1.5	ko:K01805,ko:K03079	ko00040,ko00051,ko00053,ko01100,ko01120,map00040,map00051,map00053,map01100,map01120	M00550	R00878,R01432,R03244	RC00376,RC00516,RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	AP_endonuc_2
SX3_k127_6413571_12	401526.TcarDRAFT_2389	4.711e-71	254.0	COG1122@1|root,COG1122@2|Bacteria,1TSSM@1239|Firmicutes,4H3K2@909932|Negativicutes	909932|Negativicutes	P	ABC transporter	-	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
SX3_k127_6413571_15	243231.GSU1280	6.025e-45	173.0	COG0619@1|root,COG0619@2|Bacteria,1R2DN@1224|Proteobacteria,43B6A@68525|delta/epsilon subdivisions,2X6JT@28221|Deltaproteobacteria,43S05@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Cobalt transport protein	nikQ	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
SX3_k127_6413571_8	1449126.JQKL01000006_gene825	4.959e-93	315.0	COG0310@1|root,COG0310@2|Bacteria,1TPEN@1239|Firmicutes,248S9@186801|Clostridia	186801|Clostridia	P	PFAM cobalamin (vitamin B12) biosynthesis CbiM	cbiM2	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM,PDGLE
SX3_k127_6413571_24	428125.CLOLEP_00887	4.96e-12	74.0	COG4635@1|root,COG4635@2|Bacteria,1V6RV@1239|Firmicutes,24N9M@186801|Clostridia	186801|Clostridia	CH	Flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_5
SX3_k127_6413571_10	1167006.UWK_01188	1.202e-83	283.0	COG2316@1|root,COG2316@2|Bacteria,1RA50@1224|Proteobacteria,42QZZ@68525|delta/epsilon subdivisions,2WMUN@28221|Deltaproteobacteria,2MJHQ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
SX3_k127_6413571_6	744872.Spica_1257	9.463e-110	385.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SX3_k127_6413571_22	1307761.L21SP2_1008	1.355e-22	104.0	COG1522@1|root,COG1522@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	asnC	-	-	ko:K03718,ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_AsnC-type
SX3_k127_6413571_3	525897.Dbac_2014	3.738e-155	499.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2WIS3@28221|Deltaproteobacteria,2M8HV@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
SX3_k127_6413571_19	944479.JQLX01000012_gene1077	9.195e-33	142.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,42MCS@68525|delta/epsilon subdivisions,2WQGI@28221|Deltaproteobacteria,2M799@213113|Desulfurellales	28221|Deltaproteobacteria	O	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
SX3_k127_6413571_11	1304284.L21TH_2026	3.423e-78	275.0	COG0420@1|root,COG0420@2|Bacteria,1V3MP@1239|Firmicutes,24J4M@186801|Clostridia	186801|Clostridia	L	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
SX3_k127_6413571_13	1293054.HSACCH_02648	6.346e-49	201.0	COG0419@1|root,COG0419@2|Bacteria,1UQNY@1239|Firmicutes,24UHC@186801|Clostridia	186801|Clostridia	L	AAA domain	-	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_27
SX3_k127_6413571_2	1123376.AUIU01000012_gene1395	1.574e-163	549.0	COG2887@1|root,COG2887@2|Bacteria	2|Bacteria	L	Belongs to the helicase family. UvrD subfamily	-	-	-	-	-	-	-	-	-	-	-	-	AAA_24,PDDEXK_1
SX3_k127_6413571_1	1123376.AUIU01000012_gene1396	1.539e-199	661.0	COG1074@1|root,COG1074@2|Bacteria,3J16M@40117|Nitrospirae	40117|Nitrospirae	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
SX3_k127_6413571_9	926561.KB900617_gene1425	5.128e-89	307.0	COG1228@1|root,COG1228@2|Bacteria,1TQQ0@1239|Firmicutes,24EHA@186801|Clostridia	186801|Clostridia	Q	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
SX3_k127_6413571_27	293826.Amet_0327	0.0001674	47.0	COG1053@1|root,COG3976@1|root,COG1053@2|Bacteria,COG3976@2|Bacteria,1TPAR@1239|Firmicutes,247SY@186801|Clostridia,36DR3@31979|Clostridiaceae	186801|Clostridia	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein	-	-	1.3.5.1,1.3.5.4	ko:K00239,ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,FMN_bind,FMN_red
SX3_k127_6425402_2	744872.Spica_1191	3.331e-50	185.0	COG2872@1|root,COG2872@2|Bacteria	2|Bacteria	S	Ser-tRNA(Ala) hydrolase activity	alaXM	GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872,ko:K07050	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
SX3_k127_6425402_3	744872.Spica_1661	1.962e-37	156.0	2CDKX@1|root,32RXZ@2|Bacteria,2J91F@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF4387)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4387
SX3_k127_6425402_0	744872.Spica_1660	8.589e-199	629.0	COG1574@1|root,COG1574@2|Bacteria,2J6CH@203691|Spirochaetes	203691|Spirochaetes	S	Pfam:DUF1446	-	-	-	-	-	-	-	-	-	-	-	-	AtuA
SX3_k127_6425402_1	744872.Spica_1659	2.662e-93	310.0	COG3799@1|root,COG3799@2|Bacteria,2J78A@203691|Spirochaetes	203691|Spirochaetes	H	Methylaspartate ammonia-lyase	-	-	4.3.1.2	ko:K04835	ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200	M00740	R03696	RC00979	ko00000,ko00001,ko00002,ko01000	-	-	-	MAAL_C,MAAL_N
SX3_k127_6427601_21	1121946.AUAX01000011_gene4089	4.032e-27	128.0	COG2273@1|root,COG2273@2|Bacteria,2GKFN@201174|Actinobacteria,4DH60@85008|Micromonosporales	201174|Actinobacteria	G	Hydrolase Family 16	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,F5_F8_type_C
SX3_k127_6427601_19	1302858.I871_01700	1.382e-29	136.0	COG1652@1|root,COG1652@2|Bacteria	2|Bacteria	S	positive regulation of growth rate	lysM	-	-	-	-	-	-	-	-	-	-	-	LysM
SX3_k127_6427601_7	760011.Spico_0956	6.163e-128	423.0	COG1109@1|root,COG1109@2|Bacteria,2J5GY@203691|Spirochaetes	203691|Spirochaetes	G	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
SX3_k127_6427601_4	573413.Spirs_2474	1.715e-139	459.0	COG0786@1|root,COG0786@2|Bacteria,2J7YK@203691|Spirochaetes	203691|Spirochaetes	E	glutamate symporter	gltS	-	-	ko:K03312	-	-	-	-	ko00000,ko02000	2.A.27	-	-	Glt_symporter
SX3_k127_6427601_0	744872.Spica_0331	0.0	1167.0	COG0058@1|root,COG0058@2|Bacteria,2J5KC@203691|Spirochaetes	203691|Spirochaetes	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	malP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
SX3_k127_6427601_12	665571.STHERM_c01930	1.164e-81	278.0	COG1811@1|root,COG1811@2|Bacteria,2J7KZ@203691|Spirochaetes	203691|Spirochaetes	S	Na channel or pump	-	-	-	ko:K07150	-	-	-	-	ko00000	-	-	-	DUF554
SX3_k127_6427601_22	1307761.L21SP2_0278	1.117e-26	116.0	28VUA@1|root,2ZHVZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_6427601_9	744872.Spica_2328	1.255e-110	389.0	COG0169@1|root,COG0710@1|root,COG0169@2|Bacteria,COG0710@2|Bacteria,2J570@203691|Spirochaetes	203691|Spirochaetes	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25,4.2.1.10	ko:K13832	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413,R03084	RC00206,RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I,Shikimate_DH,Shikimate_dh_N
SX3_k127_6427601_5	1415774.U728_2359	7.181e-139	450.0	COG0075@1|root,COG0075@2|Bacteria,1TPS0@1239|Firmicutes,24919@186801|Clostridia,36E72@31979|Clostridiaceae	186801|Clostridia	E	Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
SX3_k127_6427601_3	744872.Spica_0275	1.674e-148	484.0	COG0462@1|root,COG0462@2|Bacteria,2J5IY@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the ribose-phosphate pyrophosphokinase family	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
SX3_k127_6427601_11	644282.Deba_0146	3.703e-94	318.0	COG0451@1|root,COG0451@2|Bacteria,1QX8V@1224|Proteobacteria,43C1V@68525|delta/epsilon subdivisions,2X5FV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Polysaccharide biosynthesis protein	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
SX3_k127_6427601_2	1123274.KB899426_gene2795	1.103e-203	670.0	COG0726@1|root,COG0726@2|Bacteria,2J5Y1@203691|Spirochaetes	203691|Spirochaetes	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Polysacc_deac_1
SX3_k127_6427601_18	573413.Spirs_3678	4.634e-34	136.0	COG1516@1|root,COG1516@2|Bacteria,2J7XT@203691|Spirochaetes	203691|Spirochaetes	N	flagellar protein FliS	fliS	-	-	ko:K02422	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliS
SX3_k127_6427601_25	1480694.DC28_12610	1.095e-21	101.0	2FBJ1@1|root,343Q9@2|Bacteria,2J8G6@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	FlgN
SX3_k127_6427601_1	667014.Thein_1717	2.627e-218	709.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GHDG@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
SX3_k127_6427601_17	573413.Spirs_3675	5.71e-44	170.0	COG0237@1|root,COG0237@2|Bacteria,2J810@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
SX3_k127_6427601_27	1123274.KB899426_gene2790	9.994e-15	87.0	COG3087@1|root,COG3087@2|Bacteria,2J8S5@203691|Spirochaetes	203691|Spirochaetes	D	PFAM Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
SX3_k127_6427601_28	797114.C475_17018	2.652e-06	56.0	COG1735@1|root,arCOG07263@2157|Archaea,2XWF4@28890|Euryarchaeota,23TRY@183963|Halobacteria	183963|Halobacteria	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	ko:K07048	-	-	-	-	ko00000	-	-	-	PTE
SX3_k127_6427601_10	945713.IALB_2711	3.584e-108	365.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	bshA	GO:0003674,GO:0003824,GO:0016740,GO:0016757	-	ko:K00754	-	-	-	-	ko00000,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1
SX3_k127_6427601_8	1307761.L21SP2_0293	1.32e-112	373.0	COG1045@1|root,COG1045@2|Bacteria,2J73S@203691|Spirochaetes	203691|Spirochaetes	E	Serine acetyltransferase	-	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
SX3_k127_6427601_24	262724.TT_C0754	9.35e-24	107.0	COG1963@1|root,COG1963@2|Bacteria,1WJV3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Acid phosphatase vanadium-dependent haloperoxidase related	-	-	-	ko:K09775	-	-	-	-	ko00000	-	-	-	DUF212
SX3_k127_6427601_15	1125863.JAFN01000001_gene2321	4.218e-58	213.0	COG0778@1|root,COG0778@2|Bacteria,1RBBW@1224|Proteobacteria,42QWC@68525|delta/epsilon subdivisions,2WMVU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SX3_k127_6427601_23	867845.KI911784_gene2170	4.053e-25	110.0	COG1669@1|root,COG1669@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	ko:K07061	-	-	-	-	ko00000,ko02048	-	-	-	NTP_transf_2
SX3_k127_6427601_26	1521187.JPIM01000021_gene140	6.871e-19	88.0	COG2250@1|root,COG2250@2|Bacteria	2|Bacteria	S	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
SX3_k127_6427601_13	665571.STHERM_c22100	1.036e-64	237.0	COG2843@1|root,COG2843@2|Bacteria,2J6GA@203691|Spirochaetes	203691|Spirochaetes	M	Bacterial capsule synthesis protein	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
SX3_k127_6427601_20	1480694.DC28_01060	4.654e-28	131.0	COG1470@1|root,COG1470@2|Bacteria,2JAW0@203691|Spirochaetes	203691|Spirochaetes	S	PEGA domain	-	-	-	-	-	-	-	-	-	-	-	-	PEGA
SX3_k127_6427601_16	889378.Spiaf_1719	2.91e-55	205.0	COG0457@1|root,COG0457@2|Bacteria,2JAI6@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_6427601_6	573413.Spirs_2898	9.712e-136	449.0	COG0389@1|root,COG0389@2|Bacteria,2J5NZ@203691|Spirochaetes	203691|Spirochaetes	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
SX3_k127_6427601_14	1123274.KB899412_gene1488	2.661e-63	243.0	2DGWT@1|root,2ZXJS@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_6480909_20	247490.KSU1_B0236	1.535e-36	146.0	COG0540@1|root,COG0540@2|Bacteria,2IXJB@203682|Planctomycetes	203682|Planctomycetes	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
SX3_k127_6480909_21	545694.TREPR_2415	2.65e-30	130.0	COG0564@1|root,COG0564@2|Bacteria,2J82Z@203691|Spirochaetes	203691|Spirochaetes	J	Pseudouridine synthase	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
SX3_k127_6480909_16	243275.TDE_1290	1.435e-52	207.0	2BN9R@1|root,32GX8@2|Bacteria,2JAW7@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_6480909_5	1499967.BAYZ01000069_gene1886	1.647e-107	364.0	COG0167@1|root,COG0167@2|Bacteria,2NPB9@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
SX3_k127_6480909_15	869209.Tresu_0906	1.435e-54	203.0	COG0761@1|root,COG0761@2|Bacteria,2J56Z@203691|Spirochaetes	203691|Spirochaetes	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
SX3_k127_6480909_13	665571.STHERM_c17140	2.365e-60	222.0	COG0142@1|root,COG0142@2|Bacteria	2|Bacteria	H	isoprenoid biosynthetic process	idsA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
SX3_k127_6480909_1	744872.Spica_2367	1.317e-186	593.0	COG0282@1|root,COG0282@2|Bacteria,2J57M@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
SX3_k127_6480909_10	1480694.DC28_14920	1.888e-82	284.0	COG0812@1|root,COG0812@2|Bacteria,2J5SE@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
SX3_k127_6480909_3	665571.STHERM_c18260	7.08e-176	571.0	COG0215@1|root,COG0215@2|Bacteria,2J618@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
SX3_k127_6480909_17	744872.Spica_0667	5.968e-45	170.0	COG1595@1|root,COG1595@2|Bacteria,2J64C@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SX3_k127_6480909_24	889378.Spiaf_2487	7.844e-19	98.0	2FF1T@1|root,34707@2|Bacteria,2J82I@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_6480909_6	573413.Spirs_2150	8.664e-104	359.0	COG1305@1|root,COG1305@2|Bacteria,2J57S@203691|Spirochaetes	203691|Spirochaetes	E	IPT TIG domain	-	-	-	-	-	-	-	-	-	-	-	-	TIG,Transglut_core
SX3_k127_6480909_2	744872.Spica_0671	2.772e-186	591.0	COG0664@1|root,COG0664@2|Bacteria,2J5G6@203691|Spirochaetes	203691|Spirochaetes	T	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
SX3_k127_6480909_26	1121481.AUAS01000012_gene353	2.377e-05	56.0	COG0392@1|root,COG0392@2|Bacteria,4NM19@976|Bacteroidetes,47TG8@768503|Cytophagia	976|Bacteroidetes	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
SX3_k127_6480909_14	671143.DAMO_2999	1.647e-56	212.0	COG0438@1|root,COG0438@2|Bacteria,2NPWY@2323|unclassified Bacteria	2|Bacteria	M	Glycosyltransferase Family 4	recX	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006629,GO:0006643,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046872,GO:0071704,GO:1901576	2.4.1.337	ko:K19002	ko00561,ko01100,map00561,map01100	-	R10850	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
SX3_k127_6480909_18	665571.STHERM_c20830	7.919e-45	171.0	COG0494@1|root,COG0494@2|Bacteria,2J7P7@203691|Spirochaetes	203691|Spirochaetes	L	Belongs to the Nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
SX3_k127_6480909_12	926550.CLDAP_35620	1.15e-66	242.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	ko:K02025,ko:K05814,ko:K10118,ko:K10237,ko:K10241,ko:K15771,ko:K17235,ko:K17242,ko:K17316	ko02010,map02010	M00196,M00198,M00204,M00206,M00207,M00491,M00600,M00602,M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.17,3.A.1.1.2,3.A.1.1.23,3.A.1.1.24,3.A.1.1.28,3.A.1.1.3,3.A.1.1.30,3.A.1.1.34,3.A.1.1.39	-	-	BPD_transp_1
SX3_k127_6480909_11	649638.Trad_2281	2.206e-82	282.0	COG0395@1|root,COG0395@2|Bacteria,1WJ2E@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	ABC-type sugar transport system, permease component	-	-	-	ko:K02026,ko:K05815	ko02010,map02010	M00198,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.3	-	-	BPD_transp_1
SX3_k127_6480909_7	649638.Trad_2282	1.221e-96	343.0	COG1653@1|root,COG1653@2|Bacteria,1WIUT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K02027,ko:K05813	ko02010,map02010	M00198,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.3	-	-	SBP_bac_8
SX3_k127_6480909_9	1173028.ANKO01000155_gene4447	1.958e-90	315.0	COG0204@1|root,COG0204@2|Bacteria,1G0U3@1117|Cyanobacteria,1H8WE@1150|Oscillatoriales	1117|Cyanobacteria	I	SMART Phospholipid glycerol acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
SX3_k127_6480909_25	1121403.AUCV01000003_gene1738	1.893e-06	53.0	COG4191@1|root,COG5000@1|root,COG4191@2|Bacteria,COG5000@2|Bacteria,1R2HC@1224|Proteobacteria,42VJW@68525|delta/epsilon subdivisions,2WR7V@28221|Deltaproteobacteria,2MPPK@213118|Desulfobacterales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_6480909_4	1047013.AQSP01000142_gene195	4.251e-115	382.0	COG0787@1|root,COG0787@2|Bacteria,2NP3R@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
SX3_k127_6480909_19	926569.ANT_00580	3.413e-42	165.0	COG2227@1|root,COG2227@2|Bacteria,2G9HD@200795|Chloroflexi	200795|Chloroflexi	H	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
SX3_k127_6480909_8	331678.Cphamn1_0504	2.77e-95	320.0	COG1145@1|root,COG1145@2|Bacteria,1FEGQ@1090|Chlorobi	1090|Chlorobi	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
SX3_k127_6480909_22	944480.ATUV01000002_gene166	1.79e-26	117.0	COG0664@1|root,COG0664@2|Bacteria,1MZZD@1224|Proteobacteria,42QUX@68525|delta/epsilon subdivisions,2WMWV@28221|Deltaproteobacteria,2M752@213113|Desulfurellales	28221|Deltaproteobacteria	K	Cyclic nucleotide-monophosphate binding domain	-	-	-	ko:K01420,ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
SX3_k127_6480909_23	1175306.GWL_04390	1.363e-22	104.0	COG3744@1|root,COG3744@2|Bacteria,1RJ4K@1224|Proteobacteria,2VTJR@28216|Betaproteobacteria,477PR@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
SX3_k127_6480909_27	1121430.JMLG01000005_gene802	0.0004874	46.0	COG4118@1|root,COG4118@2|Bacteria,1VAKT@1239|Firmicutes,24PQQ@186801|Clostridia,266EB@186807|Peptococcaceae	186801|Clostridia	D	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
SX3_k127_6480909_0	665571.STHERM_c14560	1.391e-251	785.0	COG0129@1|root,COG0129@2|Bacteria	2|Bacteria	EG	dihydroxy-acid dehydratase activity	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1259,iECIAI39_1322.ECIAI39_3015	ILVD_EDD
SX3_k127_6685842_20	1330700.JQNC01000003_gene1832	2.508e-33	143.0	COG0477@1|root,COG2814@2|Bacteria,1WJAR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EGP	PFAM Major Facilitator Superfamily	-	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1,Sugar_tr
SX3_k127_6685842_15	665571.STHERM_c12690	9.045e-73	250.0	COG0231@1|root,COG0231@2|Bacteria,2J69Z@203691|Spirochaetes	203691|Spirochaetes	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
SX3_k127_6685842_14	1123274.KB899426_gene2781	6.508e-77	271.0	COG2269@1|root,COG2269@2|Bacteria,2J61T@203691|Spirochaetes	203691|Spirochaetes	J	synthetase (class II)	-	-	-	ko:K04568	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	tRNA-synt_2
SX3_k127_6685842_0	573413.Spirs_3660	7.105e-244	786.0	COG1026@1|root,COG1026@2|Bacteria,2J67R@203691|Spirochaetes	203691|Spirochaetes	S	peptidase, M16	-	-	-	ko:K06972	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M16C_assoc,Peptidase_M16,Peptidase_M16_C
SX3_k127_6685842_2	665571.STHERM_c16110	3.348e-131	424.0	COG1234@1|root,COG1234@2|Bacteria,2J6E7@203691|Spirochaetes	203691|Spirochaetes	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
SX3_k127_6685842_23	35754.JNYJ01000008_gene3415	3.648e-05	51.0	COG2186@1|root,COG2186@2|Bacteria,2HGS0@201174|Actinobacteria,4DJX6@85008|Micromonosporales	201174|Actinobacteria	K	FCD	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
SX3_k127_6685842_18	706587.Desti_5357	1.255e-51	191.0	COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,42MVJ@68525|delta/epsilon subdivisions,2WKM4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	methylmalonate-semialdehyde dehydrogenase	mmsA	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
SX3_k127_6685842_21	706587.Desti_5357	1.117e-14	76.0	COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,42MVJ@68525|delta/epsilon subdivisions,2WKM4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	methylmalonate-semialdehyde dehydrogenase	mmsA	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
SX3_k127_6685842_19	706587.Desti_5357	2.729e-42	158.0	COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,42MVJ@68525|delta/epsilon subdivisions,2WKM4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	methylmalonate-semialdehyde dehydrogenase	mmsA	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
SX3_k127_6685842_13	401526.TcarDRAFT_1939	8.218e-79	273.0	COG1893@1|root,COG1893@2|Bacteria,1UM1M@1239|Firmicutes,4H595@909932|Negativicutes	909932|Negativicutes	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	-	-	-	-	-	-	-	-	-	-	ApbA,ApbA_C
SX3_k127_6685842_3	562970.Btus_3056	2.379e-129	434.0	COG0624@1|root,COG0624@2|Bacteria,1TPMJ@1239|Firmicutes,4HB39@91061|Bacilli,279ND@186823|Alicyclobacillaceae	91061|Bacilli	E	Peptidase dimerisation domain	dapE_3	-	3.5.1.16,3.5.1.18	ko:K01438,ko:K01439	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00669,R02734,R09107	RC00064,RC00090,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
SX3_k127_6685842_8	379066.GAU_3549	7.853e-95	327.0	COG0624@1|root,COG0624@2|Bacteria	2|Bacteria	E	succinyl-diaminopimelate desuccinylase activity	dapE2	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
SX3_k127_6685842_12	545694.TREPR_0440	6.648e-79	271.0	COG0411@1|root,COG0411@2|Bacteria,2J9W2@203691|Spirochaetes	203691|Spirochaetes	E	branched-chain amino acid	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
SX3_k127_6685842_9	545694.TREPR_0441	2.826e-93	312.0	COG0410@1|root,COG0410@2|Bacteria,2J5VQ@203691|Spirochaetes	203691|Spirochaetes	E	ABC-type branched-chain amino acid transport systems ATPase component	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
SX3_k127_6685842_5	545694.TREPR_0442	5.242e-106	356.0	COG0559@1|root,COG0559@2|Bacteria	2|Bacteria	E	leucine import across plasma membrane	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
SX3_k127_6685842_11	545694.TREPR_0443	2.939e-80	277.0	COG4177@1|root,COG4177@2|Bacteria	2|Bacteria	E	L-phenylalanine transmembrane transporter activity	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
SX3_k127_6685842_1	545694.TREPR_0444	8.624e-145	468.0	COG0683@1|root,COG0683@2|Bacteria	2|Bacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
SX3_k127_6685842_17	1121289.JHVL01000004_gene2118	9.629e-67	233.0	COG4869@1|root,COG4869@2|Bacteria,1V242@1239|Firmicutes,24816@186801|Clostridia,36E22@31979|Clostridiaceae	186801|Clostridia	Q	Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate	pduL	-	2.3.1.8	ko:K15024	ko00430,ko00620,ko00640,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00720,map01100,map01120,map01200	M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans,PTAC
SX3_k127_6685842_10	386415.NT01CX_1082	1.954e-90	308.0	COG3191@1|root,COG3191@2|Bacteria,1TP60@1239|Firmicutes,24AVR@186801|Clostridia,36DNF@31979|Clostridiaceae	186801|Clostridia	EQ	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S58
SX3_k127_6685842_7	1121403.AUCV01000045_gene1128	1.429e-98	329.0	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,42MES@68525|delta/epsilon subdivisions,2WIQK@28221|Deltaproteobacteria,2MIUS@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
SX3_k127_6685842_6	545694.TREPR_2504	1.401e-98	331.0	COG1131@1|root,COG1131@2|Bacteria,2J5JM@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_6685842_16	545695.TREAZ_0403	2.554e-67	250.0	COG1277@1|root,COG1277@2|Bacteria,2J6H8@203691|Spirochaetes	203691|Spirochaetes	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	nosY2	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3,ABC2_membrane_4
SX3_k127_6685842_4	744872.Spica_1288	2.232e-107	377.0	COG3225@1|root,COG3225@2|Bacteria,2J6NB@203691|Spirochaetes	203691|Spirochaetes	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
SX3_k127_6685842_22	545695.TREAZ_0406	3.378e-13	79.0	2A5NU@1|root,30UDM@2|Bacteria,2J8P3@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
SX3_k127_6685888_1	573413.Spirs_0088	4.388e-165	535.0	COG2812@1|root,COG2812@2|Bacteria,2J5A9@203691|Spirochaetes	203691|Spirochaetes	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
SX3_k127_6685888_5	1123274.KB899407_gene394	6.734e-25	107.0	COG0718@1|root,COG0718@2|Bacteria,2J90U@203691|Spirochaetes	203691|Spirochaetes	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
SX3_k127_6685888_4	744872.Spica_0201	1.95e-72	249.0	COG0353@1|root,COG0353@2|Bacteria,2J74I@203691|Spirochaetes	203691|Spirochaetes	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
SX3_k127_6685888_0	889378.Spiaf_2854	8.099e-201	634.0	COG3408@1|root,COG3408@2|Bacteria,2J5J1@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Trehalase	-	-	-	-	-	-	-	-	-	-	-	-	Trehalase
SX3_k127_6685888_6	573413.Spirs_1042	3.311e-21	95.0	COG0721@1|root,COG0721@2|Bacteria	2|Bacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	iAF987.Gmet_0076	Glu-tRNAGln
SX3_k127_6685888_2	665571.STHERM_c22200	1.981e-141	468.0	COG0154@1|root,COG0154@2|Bacteria,2J58P@203691|Spirochaetes	203691|Spirochaetes	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
SX3_k127_6685888_3	665571.STHERM_c22190	1.455e-119	413.0	COG0064@1|root,COG0064@2|Bacteria,2J58X@203691|Spirochaetes	203691|Spirochaetes	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
SX3_k127_672615_4	1121405.dsmv_3495	9.257e-27	115.0	COG1150@1|root,COG1150@2|Bacteria,1N429@1224|Proteobacteria,42U6R@68525|delta/epsilon subdivisions,2WQNZ@28221|Deltaproteobacteria,2MKP7@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_17
SX3_k127_672615_3	1121405.dsmv_3496	1.246e-37	158.0	COG2181@1|root,COG2181@2|Bacteria,1RJV5@1224|Proteobacteria,42SZ9@68525|delta/epsilon subdivisions,2WPYQ@28221|Deltaproteobacteria,2MK7G@213118|Desulfobacterales	28221|Deltaproteobacteria	C	nitrate reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_672615_1	926569.ANT_01260	7.098e-141	454.0	COG0549@1|root,COG0549@2|Bacteria,2G6C7@200795|Chloroflexi	200795|Chloroflexi	E	Amino acid kinase family	-	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
SX3_k127_672615_0	335543.Sfum_2378	2.235e-218	695.0	COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,42MST@68525|delta/epsilon subdivisions,2WKAN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
SX3_k127_672615_2	525903.Taci_0913	1.367e-40	158.0	COG3404@1|root,COG3404@2|Bacteria,3TB0V@508458|Synergistetes	508458|Synergistetes	E	PFAM Formiminotransferase-cyclodeaminase	-	-	-	-	-	-	-	-	-	-	-	-	FTCD_C
SX3_k127_797770_12	573413.Spirs_2041	8.453e-46	168.0	COG0782@1|root,COG1747@1|root,COG0782@2|Bacteria,COG1747@2|Bacteria,2J5MW@203691|Spirochaetes	203691|Spirochaetes	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	-	-	-	-	-	-	-	-	-	GreA_GreB,GreA_GreB_N
SX3_k127_797770_6	744872.Spica_1366	3.811e-82	283.0	COG0457@1|root,COG0457@2|Bacteria,2J7GS@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19,TPR_8
SX3_k127_797770_13	573413.Spirs_2047	1.642e-44	185.0	COG1729@1|root,COG1729@2|Bacteria,2J5PP@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
SX3_k127_797770_10	573413.Spirs_2048	2.097e-60	224.0	COG1361@1|root,COG1361@2|Bacteria	2|Bacteria	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Cohesin,DUF11,SLH
SX3_k127_797770_9	573413.Spirs_2049	1.665e-73	270.0	COG0457@1|root,COG0457@2|Bacteria,2J5D0@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19,TPR_2
SX3_k127_797770_14	335543.Sfum_2470	2.952e-41	156.0	COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,42SMU@68525|delta/epsilon subdivisions,2WP4P@28221|Deltaproteobacteria,2MRVA@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
SX3_k127_797770_7	368407.Memar_1721	6.651e-77	268.0	COG1194@1|root,arCOG00462@2157|Archaea,2XSU9@28890|Euryarchaeota,2NBC3@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM HhH-GPD family protein	-	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
SX3_k127_797770_4	744872.Spica_1372	7.353e-107	357.0	COG0462@1|root,COG0462@2|Bacteria,2J68G@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the ribose-phosphate pyrophosphokinase family	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
SX3_k127_797770_3	573413.Spirs_2051	1.115e-166	533.0	COG0468@1|root,COG0468@2|Bacteria,2J5G5@203691|Spirochaetes	203691|Spirochaetes	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
SX3_k127_797770_15	665571.STHERM_c11010	1.952e-37	146.0	COG0801@1|root,COG0801@2|Bacteria,2J8EN@203691|Spirochaetes	203691|Spirochaetes	H	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
SX3_k127_797770_5	1123274.KB899421_gene1782	1.48e-92	315.0	COG1354@1|root,COG1354@2|Bacteria,2J5RF@203691|Spirochaetes	203691|Spirochaetes	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
SX3_k127_797770_11	545695.TREAZ_0509	3.006e-60	214.0	COG1386@1|root,COG1386@2|Bacteria,2J75V@203691|Spirochaetes	203691|Spirochaetes	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
SX3_k127_797770_8	889378.Spiaf_1517	7.789e-75	259.0	COG1187@1|root,COG1187@2|Bacteria,2J5AJ@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.21,5.4.99.22	ko:K06178,ko:K06182	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
SX3_k127_797770_16	273068.TTE1350	1.145e-36	147.0	COG0283@1|root,COG0283@2|Bacteria,1V3IA@1239|Firmicutes,24HEF@186801|Clostridia,42GBW@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
SX3_k127_797770_1	744872.Spica_1379	9.077e-224	706.0	COG0539@1|root,COG0539@2|Bacteria,2J5DZ@203691|Spirochaetes	203691|Spirochaetes	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Cytidylate_kin,S1
SX3_k127_797770_2	744872.Spica_1380	3.35e-201	638.0	COG3829@1|root,COG3829@2|Bacteria,2J63K@203691|Spirochaetes	203691|Spirochaetes	KT	Transcriptional regulator containing GAF AAA-type ATPase and DNA binding domains	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,Sigma54_activat
SX3_k127_797770_17	573413.Spirs_2058	4.88e-29	133.0	COG1729@1|root,COG1729@2|Bacteria,2J7YF@203691|Spirochaetes	203691|Spirochaetes	S	TPR domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_16,TPR_6,TPR_8
SX3_k127_797770_0	665571.STHERM_c10940	9.98e-284	901.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,2J6FV@203691|Spirochaetes	203691|Spirochaetes	T	Adenylate guanylate cyclase catalytic domain protein	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
SX3_k127_832954_5	926569.ANT_07390	1.231e-123	400.0	COG1744@1|root,COG1744@2|Bacteria,2G85I@200795|Chloroflexi	200795|Chloroflexi	S	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
SX3_k127_832954_15	573413.Spirs_4036	1.059e-42	164.0	COG0071@1|root,COG0071@2|Bacteria,2J7MQ@203691|Spirochaetes	203691|Spirochaetes	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
SX3_k127_832954_8	292459.STH2587	2.328e-93	331.0	COG1686@1|root,COG1686@2|Bacteria,1TQN0@1239|Firmicutes,249B3@186801|Clostridia	186801|Clostridia	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
SX3_k127_832954_6	32057.KB217478_gene1132	1.202e-110	370.0	COG1162@1|root,COG1162@2|Bacteria,1G18W@1117|Cyanobacteria	1117|Cyanobacteria	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	-	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
SX3_k127_832954_14	1499967.BAYZ01000041_gene2334	4.219e-47	178.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	VVA1313	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SX3_k127_832954_0	234267.Acid_1134	9.746e-205	646.0	COG4225@1|root,COG4225@2|Bacteria,3Y6Y6@57723|Acidobacteria	57723|Acidobacteria	S	Glycosyl Hydrolase Family 88	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_88
SX3_k127_832954_12	1267535.KB906767_gene5171	2.042e-73	254.0	COG0662@1|root,COG0662@2|Bacteria,3Y6AM@57723|Acidobacteria	57723|Acidobacteria	G	Mannose-6-phosphate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SX3_k127_832954_1	471854.Dfer_4759	5.664e-179	568.0	COG0673@1|root,COG0673@2|Bacteria,4NKJ1@976|Bacteroidetes,47JK9@768503|Cytophagia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX3_k127_832954_10	504472.Slin_2838	3.749e-88	308.0	COG1028@1|root,COG1028@2|Bacteria,4NHVK@976|Bacteroidetes,47K2F@768503|Cytophagia	976|Bacteroidetes	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
SX3_k127_832954_11	1448389.BAVQ01000002_gene2863	2.648e-80	273.0	2DBMA@1|root,2Z9Y3@2|Bacteria,2I9ER@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
SX3_k127_832954_16	661478.OP10G_2097	9.036e-26	115.0	COG0316@1|root,COG0316@2|Bacteria	2|Bacteria	S	protein maturation	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
SX3_k127_832954_9	443143.GM18_0265	3.247e-91	317.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,42NCH@68525|delta/epsilon subdivisions,2WJDR@28221|Deltaproteobacteria,43TRH@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
SX3_k127_832954_3	1125863.JAFN01000001_gene1250	4.621e-137	452.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MXG@68525|delta/epsilon subdivisions,2WJ6G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K11358	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
SX3_k127_832954_2	1185876.BN8_04974	1.539e-148	479.0	COG0673@1|root,COG0673@2|Bacteria,4NFY3@976|Bacteroidetes,47ME7@768503|Cytophagia	976|Bacteroidetes	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX3_k127_832954_4	1340493.JNIF01000003_gene1399	1.54e-125	410.0	COG1063@1|root,COG1063@2|Bacteria,3Y6II@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
SX3_k127_832954_18	1122611.KB903968_gene2282	0.0001259	47.0	COG1172@1|root,COG1172@2|Bacteria,2GJDW@201174|Actinobacteria,4EH61@85012|Streptosporangiales	201174|Actinobacteria	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057,ko:K10440,ko:K17209	ko02010,map02010	M00212,M00221,M00592	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.21	-	-	BPD_transp_2
SX3_k127_832954_17	649638.Trad_2192	1.182e-05	53.0	COG1028@1|root,COG1028@2|Bacteria,1WJHI@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	IQ	COGs COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase)	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SX3_k127_832954_7	383372.Rcas_1589	3.11e-101	346.0	COG1108@1|root,COG1108@2|Bacteria,2G6GH@200795|Chloroflexi,376AB@32061|Chloroflexia	32061|Chloroflexia	P	ABC-3 protein	-	-	-	ko:K09819	-	M00243	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC-3
SX3_k127_832954_13	357808.RoseRS_1258	5.864e-72	250.0	COG0803@1|root,COG0803@2|Bacteria,2G8F6@200795|Chloroflexi,37738@32061|Chloroflexia	32061|Chloroflexia	P	Belongs to the bacterial solute-binding protein 9 family	-	-	-	ko:K02077,ko:K09818	-	M00243,M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ZnuA
SX3_k127_846313_0	428125.CLOLEP_01071	2.344e-201	638.0	COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia	186801|Clostridia	G	Psort location Cytoplasmic, score 8.87	-	-	2.7.1.53	ko:K00880	ko00040,ko00053,map00040,map00053	-	R01901,R07127	RC00002,RC00017,RC00538	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
SX3_k127_846313_2	1304880.JAGB01000003_gene1063	4.822e-68	239.0	COG1751@1|root,COG1751@2|Bacteria,1V1CN@1239|Firmicutes,24G0M@186801|Clostridia	186801|Clostridia	S	PFAM Pyruvate kinase, alpha beta domain	-	-	-	ko:K09126	-	-	-	-	ko00000	-	-	-	PK_C
SX3_k127_846313_1	547042.BACCOPRO_03195	2.235e-71	252.0	COG0407@1|root,COG0407@2|Bacteria,4NTJT@976|Bacteroidetes,2FUJS@200643|Bacteroidia,4AQYC@815|Bacteroidaceae	976|Bacteroidetes	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
SX3_k127_857653_30	706587.Desti_4626	9.011e-33	140.0	COG1387@1|root,COG1387@2|Bacteria,1R9W5@1224|Proteobacteria,42QNF@68525|delta/epsilon subdivisions,2WMV0@28221|Deltaproteobacteria,2MRJE@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	DNA polymerase alpha chain like domain	-	-	-	-	-	-	-	-	-	-	-	-	PHP
SX3_k127_857653_21	637389.Acaty_c0337	1.512e-86	325.0	COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,1RPEU@1236|Gammaproteobacteria,2NBTS@225057|Acidithiobacillales	225057|Acidithiobacillales	E	Homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
SX3_k127_857653_1	760011.Spico_1795	0.0	1113.0	COG0587@1|root,COG0587@2|Bacteria,2J5B5@203691|Spirochaetes	203691|Spirochaetes	L	DNA-directed DNA polymerase	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
SX3_k127_857653_20	1499967.BAYZ01000118_gene3242	1.544e-91	314.0	COG2017@1|root,COG2017@2|Bacteria,2NQQX@2323|unclassified Bacteria	2|Bacteria	G	Domain of unknown function (DUF4432)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4432
SX3_k127_857653_11	665571.STHERM_c08130	3.466e-135	444.0	COG0399@1|root,COG0399@2|Bacteria,2J62G@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the DegT DnrJ EryC1 family	spsC	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
SX3_k127_857653_4	744872.Spica_1447	5.333e-194	617.0	COG1086@1|root,COG1086@2|Bacteria,2J5C2@203691|Spirochaetes	203691|Spirochaetes	M	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding,CoA_binding_3,Polysacc_synt_2
SX3_k127_857653_27	754027.HMPREF9554_00721	4.069e-43	163.0	COG0250@1|root,COG0250@2|Bacteria,2J829@203691|Spirochaetes	203691|Spirochaetes	K	Transcription antitermination protein, NusG	-	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusG
SX3_k127_857653_29	469381.Dpep_0775	1.392e-34	148.0	COG3206@1|root,COG3206@2|Bacteria,3TAZ7@508458|Synergistetes	508458|Synergistetes	M	PFAM lipopolysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	GNVR,Wzz
SX3_k127_857653_36	665571.STHERM_c08160	1.673e-19	103.0	COG0797@1|root,COG0797@2|Bacteria,2J7K2@203691|Spirochaetes	203691|Spirochaetes	M	Sporulation and cell division repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
SX3_k127_857653_2	1123274.KB899409_gene603	8.407e-249	786.0	COG0272@1|root,COG0272@2|Bacteria,2J57Q@203691|Spirochaetes	203691|Spirochaetes	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
SX3_k127_857653_13	1259795.ARJK01000003_gene690	2.191e-126	414.0	COG1744@1|root,COG1744@2|Bacteria,1TPEU@1239|Firmicutes,248QT@186801|Clostridia,42FG6@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Basic membrane lipoprotein	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
SX3_k127_857653_6	373903.Hore_08780	8.618e-164	529.0	COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,24XN8@186801|Clostridia,3WA8J@53433|Halanaerobiales	186801|Clostridia	S	PFAM ABC transporter	yufO	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
SX3_k127_857653_18	309798.COPRO5265_0857	2.791e-92	315.0	COG4603@1|root,COG4603@2|Bacteria,1TP1F@1239|Firmicutes,2494C@186801|Clostridia,42FNB@68295|Thermoanaerobacterales	186801|Clostridia	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
SX3_k127_857653_19	1259795.ARJK01000003_gene687	7.53e-92	323.0	COG1079@1|root,COG1079@2|Bacteria,1TP8Y@1239|Firmicutes,2486N@186801|Clostridia,42FXD@68295|Thermoanaerobacterales	186801|Clostridia	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
SX3_k127_857653_35	756067.MicvaDRAFT_0877	1.17e-20	107.0	COG2211@1|root,COG2211@2|Bacteria,1G0DY@1117|Cyanobacteria,1HA1Z@1150|Oscillatoriales	1117|Cyanobacteria	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX3_k127_857653_28	1379698.RBG1_1C00001G0613	9.381e-40	155.0	COG1268@1|root,COG1268@2|Bacteria,2NPGG@2323|unclassified Bacteria	2|Bacteria	S	BioY family	bioY	-	-	ko:K02014,ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	1.B.14,2.A.88.1,2.A.88.2	-	-	BioY
SX3_k127_857653_23	1121405.dsmv_0591	1.756e-73	262.0	COG0370@1|root,COG0370@2|Bacteria,1QWMI@1224|Proteobacteria,43BSF@68525|delta/epsilon subdivisions,2X739@28221|Deltaproteobacteria,2MI8F@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Transporter of a GTP-driven Fe(2 ) uptake system	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_857653_24	518766.Rmar_2660	6.092e-67	245.0	COG1578@1|root,COG1578@2|Bacteria,4PEMD@976|Bacteroidetes,1FJAK@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Protein of unknown function DUF89	-	-	-	-	-	-	-	-	-	-	-	-	DUF89
SX3_k127_857653_17	158190.SpiGrapes_0165	5.855e-93	322.0	COG1070@1|root,COG1070@2|Bacteria,2J7TG@203691|Spirochaetes	203691|Spirochaetes	G	PFAM FGGY family of carbohydrate kinases, N-terminal domain	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
SX3_k127_857653_31	56110.Oscil6304_3898	4.008e-27	128.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1GCNJ@1117|Cyanobacteria,1HEP8@1150|Oscillatoriales	1117|Cyanobacteria	T	PFAM Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
SX3_k127_857653_33	684949.ATTJ01000002_gene334	2.265e-24	110.0	2A1VH@1|root,30Q4S@2|Bacteria,1WMIG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_857653_32	649638.Trad_1784	1.327e-26	118.0	2A1VH@1|root,30Q4S@2|Bacteria,1WMIG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_857653_0	665571.STHERM_c16630	0.0	1682.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,2J5QV@203691|Spirochaetes	203691|Spirochaetes	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K00169,ko:K03737	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034,R10866	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
SX3_k127_857653_12	313628.LNTAR_18720	2.678e-127	419.0	COG1915@1|root,COG1915@2|Bacteria	2|Bacteria	E	PFAM LOR SDH bifunctional enzyme conserved region	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_857653_8	471854.Dfer_4313	1.039e-162	533.0	COG0546@1|root,COG2870@1|root,COG0546@2|Bacteria,COG2870@2|Bacteria,4NJ8F@976|Bacteroidetes,47MRA@768503|Cytophagia	976|Bacteroidetes	M	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase,PfkB
SX3_k127_857653_16	1168034.FH5T_11665	2.21e-95	326.0	COG5505@1|root,COG5505@2|Bacteria,4NPE1@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function (DUF819)	-	-	-	-	-	-	-	-	-	-	-	-	DUF819
SX3_k127_857653_7	463191.SSEG_09933	5.579e-163	527.0	COG0001@1|root,COG0001@2|Bacteria,2IC57@201174|Actinobacteria	201174|Actinobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aldolase_II,Aminotran_3
SX3_k127_857653_14	935948.KE386494_gene356	2.491e-108	362.0	COG2768@1|root,COG2768@2|Bacteria,1TQAW@1239|Firmicutes,247IS@186801|Clostridia,42ETU@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4,Fer4_21
SX3_k127_857653_9	744872.Spica_0890	2.338e-160	512.0	COG1063@1|root,COG1063@2|Bacteria,2J5R7@203691|Spirochaetes	203691|Spirochaetes	C	PFAM Alcohol dehydrogenase GroES-like	-	-	1.1.1.103,1.1.1.14,1.1.1.303,1.1.1.4	ko:K00004,ko:K00008,ko:K00060	ko00040,ko00051,ko00260,ko00650,ko01100,map00040,map00051,map00260,map00650,map01100	M00014	R00875,R01465,R01896,R02855,R02946,R10504	RC00085,RC00102,RC00205,RC00525	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
SX3_k127_857653_10	67352.JODS01000018_gene5782	1.633e-152	495.0	COG0156@1|root,COG0156@2|Bacteria,2GISV@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA	kbl	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
SX3_k127_857653_3	573413.Spirs_1501	2.132e-205	658.0	COG1022@1|root,COG1022@2|Bacteria,2J59B@203691|Spirochaetes	203691|Spirochaetes	I	COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming)	faa1	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
SX3_k127_857653_15	673860.AciM339_1573	2.325e-99	335.0	COG0182@1|root,arCOG01123@2157|Archaea,2Y86P@28890|Euryarchaeota,3F36H@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	-	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.23	ko:K03239,ko:K08963	ko00270,ko01100,ko03013,map00270,map01100,map03013	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000,ko03012	-	-	-	IF-2B
SX3_k127_857653_25	1321815.HMPREF9193_00714	7.675e-55	214.0	COG4372@1|root,COG4372@2|Bacteria,2J5RI@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Borrelia P83 100 protein	-	-	-	-	-	-	-	-	-	-	-	-	Borrelia_P83
SX3_k127_857653_22	1089550.ATTH01000001_gene2287	5.267e-82	293.0	COG4365@1|root,COG4365@2|Bacteria,4NGCF@976|Bacteroidetes,1FJ16@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Bacillithiol biosynthesis BshC	bshC	-	-	ko:K22136	-	-	-	-	ko00000	-	-	-	BshC
SX3_k127_857653_26	1047013.AQSP01000125_gene2630	3.656e-52	208.0	COG2120@1|root,COG2120@2|Bacteria,2NPAV@2323|unclassified Bacteria	2|Bacteria	S	GlcNAc-PI de-N-acetylase	bshB1	-	-	ko:K01463	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
SX3_k127_857653_5	1304880.JAGB01000002_gene1641	1.301e-168	542.0	COG2723@1|root,COG2723@2|Bacteria,1TP19@1239|Firmicutes,2485V@186801|Clostridia	186801|Clostridia	G	Belongs to the glycosyl hydrolase 1 family	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
SX3_k127_857653_34	546271.Selsp_2224	6.972e-24	104.0	COG0607@1|root,COG0607@2|Bacteria,1U0PW@1239|Firmicutes,4H5PB@909932|Negativicutes	909932|Negativicutes	P	Rhodanese Homology Domain	pspE	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
SX3_k127_863882_3	1499967.BAYZ01000095_gene4292	4.079e-29	124.0	COG0524@1|root,COG0524@2|Bacteria	2|Bacteria	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	-	-	2.7.1.15,2.7.1.20,2.7.1.213,2.7.1.218,2.7.1.73	ko:K00852,ko:K00856,ko:K10710,ko:K22026	ko00030,ko00230,ko00240,ko01100,map00030,map00230,map00240,map01100	-	R00185,R00513,R01051,R01131,R01228,R02750,R08124	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
SX3_k127_863882_0	1487921.DP68_02640	8.99e-119	395.0	COG0673@1|root,COG0673@2|Bacteria,1TP83@1239|Firmicutes,24B6F@186801|Clostridia,36F67@31979|Clostridiaceae	186801|Clostridia	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SX3_k127_863882_1	1499967.BAYZ01000117_gene3303	1.145e-62	227.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SX3_k127_863882_2	592015.HMPREF1705_02132	2.929e-60	210.0	COG1402@1|root,COG1402@2|Bacteria	2|Bacteria	I	creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
SX3_k127_882454_9	573413.Spirs_3788	4.597e-41	169.0	COG2114@1|root,COG2114@2|Bacteria,2JAZ7@203691|Spirochaetes	203691|Spirochaetes	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_882454_6	573413.Spirs_3787	2.386e-59	222.0	COG2114@1|root,COG2114@2|Bacteria,2J9VX@203691|Spirochaetes	203691|Spirochaetes	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_882454_10	744872.Spica_0029	1.368e-40	154.0	COG0824@1|root,COG0824@2|Bacteria,2J837@203691|Spirochaetes	203691|Spirochaetes	S	acyl-CoA thioester hydrolase, YbgC YbaW family	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
SX3_k127_882454_11	909663.KI867150_gene1166	1.253e-38	151.0	COG2041@1|root,COG2041@2|Bacteria,1MWZK@1224|Proteobacteria,42W6K@68525|delta/epsilon subdivisions,2WS34@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
SX3_k127_882454_5	1121396.KB893123_gene1103	4.321e-90	306.0	COG0834@1|root,COG0834@2|Bacteria,1MV3Q@1224|Proteobacteria,42PQN@68525|delta/epsilon subdivisions,2WKV7@28221|Deltaproteobacteria,2MJFP@213118|Desulfobacterales	28221|Deltaproteobacteria	ET	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
SX3_k127_882454_3	1480694.DC28_09050	9.01e-110	363.0	COG0765@1|root,COG0765@2|Bacteria,2J5BG@203691|Spirochaetes	203691|Spirochaetes	P	TIGRFAM amine acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine family	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
SX3_k127_882454_4	889378.Spiaf_0716	1.735e-105	348.0	COG1126@1|root,COG1126@2|Bacteria,2J5V5@203691|Spirochaetes	203691|Spirochaetes	E	ABC-type polar amino acid transport system ATPase component	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
SX3_k127_882454_12	158190.SpiGrapes_0125	1.33e-21	96.0	COG0828@1|root,COG0828@2|Bacteria,2J8QT@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
SX3_k127_882454_7	545694.TREPR_0999	5.219e-54	208.0	COG0739@1|root,COG0739@2|Bacteria,2J7J7@203691|Spirochaetes	203691|Spirochaetes	M	M23 M37 peptidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
SX3_k127_882454_1	1123274.KB899430_gene1688	5.181e-193	625.0	COG0608@1|root,COG0608@2|Bacteria,2J5KW@203691|Spirochaetes	203691|Spirochaetes	L	single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
SX3_k127_882454_2	665571.STHERM_c06520	1.195e-137	450.0	COG0213@1|root,COG0213@2|Bacteria,2J607@203691|Spirochaetes	203691|Spirochaetes	F	pyrimidine-nucleoside phosphorylase	pdp	-	2.4.2.2	ko:K00756	ko00240,ko01100,map00240,map01100	-	R01570,R01876,R02296,R02484	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
SX3_k127_882454_13	1123274.KB899430_gene1687	1.874e-18	96.0	COG1514@1|root,COG1514@2|Bacteria,2JBB8@203691|Spirochaetes	203691|Spirochaetes	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
SX3_k127_882454_8	1123274.KB899430_gene1686	1.032e-43	170.0	COG1381@1|root,COG1381@2|Bacteria,2J65J@203691|Spirochaetes	203691|Spirochaetes	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
SX3_k127_882454_0	1123274.KB899430_gene1685	1.173e-227	715.0	COG0466@1|root,COG0466@2|Bacteria,2J5CV@203691|Spirochaetes	203691|Spirochaetes	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
SX3_k127_890873_19	744872.Spica_1195	3.573e-59	211.0	COG0330@1|root,COG0330@2|Bacteria,2J5TU@203691|Spirochaetes	203691|Spirochaetes	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
SX3_k127_890873_9	665571.STHERM_c17540	6.018e-121	407.0	COG3392@1|root,COG3392@2|Bacteria,2J5IE@203691|Spirochaetes	203691|Spirochaetes	L	D12 class N6 adenine-specific DNA methyltransferase	-	-	2.1.1.72	ko:K07318	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	MethyltransfD12
SX3_k127_890873_22	665571.STHERM_c17560	4.708e-35	154.0	COG0720@1|root,COG0720@2|Bacteria,2J80J@203691|Spirochaetes	203691|Spirochaetes	H	6-pyruvoyl tetrahydropterin synthase QueD family protein	queD	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
SX3_k127_890873_4	545694.TREPR_1063	5.104e-145	475.0	COG0769@1|root,COG0769@2|Bacteria,2J5HR@203691|Spirochaetes	203691|Spirochaetes	M	Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
SX3_k127_890873_13	1307761.L21SP2_1595	9.796e-107	357.0	COG1181@1|root,COG1181@2|Bacteria,2J611@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
SX3_k127_890873_21	665571.STHERM_c02040	3.627e-41	168.0	COG1600@1|root,COG1600@2|Bacteria,2JAKM@203691|Spirochaetes	203691|Spirochaetes	C	4Fe-4S double cluster binding domain	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Fer4_16
SX3_k127_890873_24	1304885.AUEY01000003_gene496	3.698e-22	96.0	COG1773@1|root,COG1773@2|Bacteria,1N731@1224|Proteobacteria,42VC4@68525|delta/epsilon subdivisions,2WRDM@28221|Deltaproteobacteria,2MKVE@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Rubredoxin	rub	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	Rubredoxin
SX3_k127_890873_10	1123274.KB899408_gene3912	2.803e-114	386.0	2EJFP@1|root,33D6N@2|Bacteria,2J5TW@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF5312
SX3_k127_890873_0	889378.Spiaf_1825	2.645e-257	810.0	COG0317@1|root,COG0317@2|Bacteria,2J5JE@203691|Spirochaetes	203691|Spirochaetes	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	spoT	-	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
SX3_k127_890873_18	665571.STHERM_c19290	4.494e-64	231.0	COG2890@1|root,COG2890@2|Bacteria,2J7VJ@203691|Spirochaetes	203691|Spirochaetes	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
SX3_k127_890873_5	744872.Spica_0421	4.651e-136	442.0	COG0216@1|root,COG0216@2|Bacteria,2J5KY@203691|Spirochaetes	203691|Spirochaetes	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
SX3_k127_890873_14	479434.Sthe_1355	3.182e-87	304.0	COG1109@1|root,COG1109@2|Bacteria,2G5YP@200795|Chloroflexi,27XV0@189775|Thermomicrobia	189775|Thermomicrobia	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
SX3_k127_890873_12	338966.Ppro_2908	1.252e-111	380.0	COG0784@1|root,COG3829@1|root,COG4191@1|root,COG0784@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WJSJ@28221|Deltaproteobacteria,43TMC@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1
SX3_k127_890873_8	1480694.DC28_07200	2.771e-121	412.0	COG1022@1|root,COG1022@2|Bacteria,2J59B@203691|Spirochaetes	203691|Spirochaetes	I	COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming)	faa1	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
SX3_k127_890873_1	744872.Spica_0750	7.574e-192	619.0	COG0488@1|root,COG0488@2|Bacteria,2J5AN@203691|Spirochaetes	203691|Spirochaetes	S	ABC transporter, ATP-binding protein	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
SX3_k127_890873_20	744872.Spica_0749	4.24e-58	224.0	2F4TS@1|root,33XG8@2|Bacteria,2J5NM@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
SX3_k127_890873_7	665571.STHERM_c18470	2.623e-121	405.0	COG0624@1|root,COG0624@2|Bacteria,2J5ZZ@203691|Spirochaetes	203691|Spirochaetes	E	COGs COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylase	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
SX3_k127_890873_23	1123274.KB899412_gene1527	1.207e-25	123.0	COG2885@1|root,COG2885@2|Bacteria,2J5X0@203691|Spirochaetes	203691|Spirochaetes	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
SX3_k127_890873_16	573413.Spirs_2858	3.956e-79	279.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,2J5H1@203691|Spirochaetes	203691|Spirochaetes	M	Transglycosylase	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
SX3_k127_890873_15	573413.Spirs_2857	7.162e-86	303.0	COG0457@1|root,COG0457@2|Bacteria,2J5XK@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_6,TPR_8
SX3_k127_890873_2	665571.STHERM_c18430	3.908e-180	575.0	COG0538@1|root,COG0538@2|Bacteria,2J5RP@203691|Spirochaetes	203691|Spirochaetes	C	PFAM isocitrate isopropylmalate dehydrogenase	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
SX3_k127_890873_25	1125699.HMPREF9194_00884	5.972e-13	79.0	2AMU1@1|root,31CQJ@2|Bacteria,2J8GB@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_890873_6	889378.Spiaf_0091	2.093e-131	443.0	COG1306@1|root,COG1306@2|Bacteria,2J5BQ@203691|Spirochaetes	203691|Spirochaetes	S	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
SX3_k127_890873_28	889378.Spiaf_2259	1.096e-05	50.0	COG1413@1|root,COG2211@1|root,COG1413@2|Bacteria,COG2211@2|Bacteria	2|Bacteria	G	Major facilitator Superfamily	-	-	-	ko:K16210	-	-	-	-	ko00000,ko02000	2.A.2.5	-	-	HEAT_2,MFS_1,MFS_2,NB-ARC,cNMP_binding
SX3_k127_890873_26	665571.STHERM_c01150	1.383e-10	74.0	COG1413@1|root,COG2211@1|root,COG1413@2|Bacteria,COG2211@2|Bacteria,2J9QA@203691|Spirochaetes	203691|Spirochaetes	CG	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
SX3_k127_890873_11	180332.JTGN01000004_gene2365	5.831e-114	381.0	28MXM@1|root,2ZB4M@2|Bacteria,1UYF1@1239|Firmicutes,24DFA@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_890873_3	1480694.DC28_11295	4.028e-159	527.0	COG1816@1|root,COG1816@2|Bacteria	2|Bacteria	F	deaminase activity	add	-	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
SX3_k127_890873_17	555088.DealDRAFT_2075	4.154e-66	241.0	arCOG03165@1|root,30AIC@2|Bacteria,1V7NB@1239|Firmicutes,24M5X@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_890873_27	1236542.BALM01000006_gene3269	3.717e-09	58.0	COG2068@1|root,COG2068@2|Bacteria,1QE5N@1224|Proteobacteria,1S3GJ@1236|Gammaproteobacteria,2QDTR@267890|Shewanellaceae	1236|Gammaproteobacteria	S	MobA-like NTP transferase domain	ygfJ	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019538,GO:0019637,GO:0019720,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061602,GO:0070567,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902759,GO:1902760	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_3649,iB21_1397.B21_02672,iECABU_c1320.ECABU_c31580,iECBD_1354.ECBD_0860,iECB_1328.ECB_02710,iECD_1391.ECD_02710,iEcHS_1320.EcHS_A3037	NTP_transf_3
SX3_k127_904331_18	502025.Hoch_0142	3.745e-22	98.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,42MCV@68525|delta/epsilon subdivisions,2WJI2@28221|Deltaproteobacteria,2YV60@29|Myxococcales	28221|Deltaproteobacteria	J	tRNA synthetases class I (W and Y)	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
SX3_k127_904331_2	335543.Sfum_3197	5.258e-223	713.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJZ3@28221|Deltaproteobacteria,2MQ7P@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
SX3_k127_904331_13	744872.Spica_1620	9.18e-45	171.0	COG2199@1|root,COG3706@2|Bacteria,2J8YI@203691|Spirochaetes	203691|Spirochaetes	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_904331_10	665571.STHERM_c11640	2.581e-73	258.0	2F8HF@1|root,340W9@2|Bacteria,2J5EY@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_904331_0	573413.Spirs_2540	0.0	1194.0	COG1197@1|root,COG1197@2|Bacteria,2J63X@203691|Spirochaetes	203691|Spirochaetes	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
SX3_k127_904331_9	639282.DEFDS_2021	3.344e-85	308.0	COG1373@1|root,COG1373@2|Bacteria,2GFZK@200930|Deferribacteres	200930|Deferribacteres	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
SX3_k127_904331_14	349521.HCH_00504	1.11e-39	166.0	COG2199@1|root,COG3706@2|Bacteria,1RD8D@1224|Proteobacteria,1S0XV@1236|Gammaproteobacteria,1XK7Z@135619|Oceanospirillales	135619|Oceanospirillales	T	overlaps another CDS with the same product name	-	-	2.7.7.65	ko:K21019	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000	-	-	-	GGDEF
SX3_k127_904331_6	439235.Dalk_2905	6.525e-124	407.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42QB7@68525|delta/epsilon subdivisions,2WM6Y@28221|Deltaproteobacteria,2MHYS@213118|Desulfobacterales	28221|Deltaproteobacteria	T	metal-dependent phosphohydrolase HD region	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
SX3_k127_904331_11	573413.Spirs_2432	5.417e-58	218.0	COG2208@1|root,COG3437@1|root,COG2208@2|Bacteria,COG3437@2|Bacteria,2JAA0@203691|Spirochaetes	203691|Spirochaetes	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Response_reg,SpoIIE
SX3_k127_904331_8	1480694.DC28_03360	1.033e-113	384.0	COG1315@1|root,COG1315@2|Bacteria,2J6E5@203691|Spirochaetes	203691|Spirochaetes	L	Pfam:DUF342	-	-	-	ko:K09749	-	-	-	-	ko00000	-	-	-	FapA
SX3_k127_904331_16	889378.Spiaf_2305	4.649e-30	122.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K03413,ko:K21993	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02000,ko02022,ko02035	1.A.16.2	-	-	Form_Nir_trans,HATPase_c,HTH_8,HisKA,Response_reg
SX3_k127_904331_5	443143.GM18_1762	1.04e-141	484.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria,43T3F@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
SX3_k127_904331_3	744872.Spica_1248	4.762e-172	552.0	COG0448@1|root,COG0448@2|Bacteria,2J5UB@203691|Spirochaetes	203691|Spirochaetes	H	Glucose-1-phosphate adenylyltransferase	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
SX3_k127_904331_1	1307761.L21SP2_1222	1.969e-306	957.0	COG1205@1|root,COG1205@2|Bacteria,2J5DK@203691|Spirochaetes	203691|Spirochaetes	L	DEAD DEAH box helicase	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
SX3_k127_904331_12	573413.Spirs_2617	7.921e-46	181.0	COG3359@1|root,COG3359@2|Bacteria,2J801@203691|Spirochaetes	203691|Spirochaetes	L	RNase_H superfamily	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
SX3_k127_904331_17	1307761.L21SP2_1225	3.393e-27	124.0	COG3393@1|root,COG3393@2|Bacteria,2J84J@203691|Spirochaetes	203691|Spirochaetes	S	Acetyltransferase GNAT family	-	-	-	ko:K06976	-	-	-	-	ko00000	-	-	-	Acetyltransf_1,Acetyltransf_10,FR47
SX3_k127_904331_4	1123274.KB899419_gene1876	2.802e-160	524.0	COG1472@1|root,COG1472@2|Bacteria,2J5CS@203691|Spirochaetes	203691|Spirochaetes	G	Glycosyl hydrolase family 3	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
SX3_k127_904331_15	525904.Tter_0676	4.108e-33	142.0	COG0095@1|root,COG0095@2|Bacteria,2NPP1@2323|unclassified Bacteria	2|Bacteria	H	Biotin/lipoate A/B protein ligase family	lipM	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
SX3_k127_904331_7	665571.STHERM_c07590	8.507e-121	401.0	COG0492@1|root,COG0492@2|Bacteria,2J7WA@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
SX3_k127_960704_28	1449049.JONW01000011_gene2345	9.139e-15	81.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,2KHYY@204458|Caulobacterales	204458|Caulobacterales	T	PFAM ATP-binding region ATPase domain protein	-	-	2.7.13.3	ko:K10125	ko02020,map02020	M00504	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
SX3_k127_960704_19	573413.Spirs_2334	1.145e-46	173.0	COG0328@1|root,COG0328@2|Bacteria,2J7Y2@203691|Spirochaetes	203691|Spirochaetes	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
SX3_k127_960704_7	309801.trd_A0017	9.258e-130	431.0	COG0606@1|root,COG0606@2|Bacteria,2G65P@200795|Chloroflexi,27Y2X@189775|Thermomicrobia	189775|Thermomicrobia	O	Magnesium chelatase, subunit ChlI	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
SX3_k127_960704_8	665571.STHERM_c05270	2.322e-124	411.0	COG0265@1|root,COG0265@2|Bacteria,2J6JY@203691|Spirochaetes	203691|Spirochaetes	O	COGs COG0265 Trypsin-like serine protease typically periplasmic contain C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
SX3_k127_960704_0	573413.Spirs_2331	2.803e-297	930.0	COG0556@1|root,COG0556@2|Bacteria,2J57B@203691|Spirochaetes	203691|Spirochaetes	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
SX3_k127_960704_21	573413.Spirs_2312	7.782e-36	149.0	COG4249@1|root,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,Peptidase_C14
SX3_k127_960704_25	573413.Spirs_2307	2.551e-17	87.0	COG3103@1|root,COG3103@2|Bacteria	2|Bacteria	T	Sh3 type 3 domain protein	yrvJ	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	3.5.1.28	ko:K01448,ko:K05772,ko:K06385	ko01503,ko02010,map01503,map02010	M00186,M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02000,ko03036	3.A.1.6.2,3.A.1.6.4	-	-	AMIN,Amidase_3,SH3_3,SLH
SX3_k127_960704_18	744872.Spica_1436	6.15e-57	219.0	COG4399@1|root,COG4399@2|Bacteria,2JAAN@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF445
SX3_k127_960704_12	1123274.KB899413_gene730	1.413e-84	292.0	COG2199@1|root,COG3706@2|Bacteria,2J9QT@203691|Spirochaetes	203691|Spirochaetes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
SX3_k127_960704_15	1169154.KB897789_gene356	9.911e-73	270.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	fbpC	-	-	ko:K02052,ko:K02062	ko02010,ko02024,map02010,map02024	M00191,M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11,3.A.1.19	-	-	ABC_tran,TOBE_2
SX3_k127_960704_4	1128421.JAGA01000002_gene569	3.772e-134	449.0	COG1178@1|root,COG1178@2|Bacteria	2|Bacteria	P	thiamine transport	thiP	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015234,GO:0015238,GO:0015893,GO:0016020,GO:0022857,GO:0035461,GO:0042221,GO:0042493,GO:0044464,GO:0045117,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071934,GO:0071944,GO:0072348,GO:0072531,GO:0090482,GO:1901474,GO:1901682	-	ko:K02063	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	iAPECO1_1312.APECO1_1915,iECIAI1_1343.ECIAI1_0067,iECO103_1326.ECO103_0068,iECO111_1330.ECO111_0069,iECO26_1355.ECO26_0069,iECOK1_1307.ECOK1_0068,iECS88_1305.ECS88_0072,iECSE_1348.ECSE_0067,iECUMN_1333.ECUMN_0068,iPC815.YPO0521,iSF_1195.SF0062,iSFxv_1172.SFxv_0064,iS_1188.S0064,iUMN146_1321.UM146_23130,iUTI89_1310.UTI89_C0075	BPD_transp_1
SX3_k127_960704_10	765420.OSCT_0522	3.66e-117	387.0	COG4143@1|root,COG4143@2|Bacteria,2G615@200795|Chloroflexi,376Q5@32061|Chloroflexia	32061|Chloroflexia	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02064	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	SBP_bac_6
SX3_k127_960704_27	1480694.DC28_14165	4.38e-15	86.0	2FJEQ@1|root,34B4E@2|Bacteria,2J8EB@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_960704_11	545695.TREAZ_0089	3.368e-93	318.0	COG0707@1|root,COG0707@2|Bacteria,2J5XF@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
SX3_k127_960704_16	573413.Spirs_1707	2.442e-65	243.0	COG0470@1|root,COG0470@2|Bacteria,2JBGE@203691|Spirochaetes	203691|Spirochaetes	L	DNA polymerase III, delta subunit	-	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2
SX3_k127_960704_5	1480694.DC28_14145	1.268e-131	430.0	COG5000@1|root,COG5000@2|Bacteria,2J5RG@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8
SX3_k127_960704_2	1307761.L21SP2_0922	1.047e-199	647.0	COG2204@1|root,COG2204@2|Bacteria,2J5NY@203691|Spirochaetes	203691|Spirochaetes	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	rrp-2	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
SX3_k127_960704_24	1227349.C170_19900	8.831e-24	117.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4HEWH@91061|Bacilli,26SAC@186822|Paenibacillaceae	91061|Bacilli	NT	chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal
SX3_k127_960704_17	879310.HMPREF9162_0136	3.146e-64	233.0	COG0472@1|root,COG0472@2|Bacteria,1TP9V@1239|Firmicutes,4H2U9@909932|Negativicutes	909932|Negativicutes	M	Glycosyltransferase, group 4 family	tagO	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
SX3_k127_960704_26	1307761.L21SP2_0923	2.874e-17	87.0	COG2214@1|root,COG2214@2|Bacteria,2J9HD@203691|Spirochaetes	203691|Spirochaetes	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
SX3_k127_960704_22	1444309.JAQG01000004_gene3556	2.838e-35	156.0	COG0253@1|root,COG0253@2|Bacteria,1TPMN@1239|Firmicutes,4HBH4@91061|Bacilli,26QWK@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
SX3_k127_960704_6	1307761.L21SP2_0924	6.844e-131	436.0	COG0527@1|root,COG0527@2|Bacteria,2J6FK@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT_7
SX3_k127_960704_3	1480694.DC28_14125	1.258e-155	498.0	COG0136@1|root,COG0136@2|Bacteria,2J5ZP@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the aspartate-semialdehyde dehydrogenase family	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
SX3_k127_960704_29	266117.Rxyl_0382	1.746e-06	59.0	COG1893@1|root,COG1893@2|Bacteria,2GP6K@201174|Actinobacteria,4CTXT@84995|Rubrobacteria	201174|Actinobacteria	H	Ketopantoate reductase PanE/ApbA C terminal	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
SX3_k127_960704_14	1480694.DC28_14120	1.59e-81	279.0	COG0005@1|root,COG0005@2|Bacteria,2J8PG@203691|Spirochaetes	203691|Spirochaetes	F	Purine nucleoside	mtnP	-	2.4.2.1,2.4.2.28	ko:K00772,ko:K03783	ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110	M00034	R01402,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
SX3_k127_960704_1	1123274.KB899428_gene1828	3.536e-254	808.0	COG1199@1|root,COG1199@2|Bacteria,2J626@203691|Spirochaetes	203691|Spirochaetes	L	Helicase	dinG	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2,RadC,ResIII
SX3_k127_960704_30	1906.SFRA_27680	2.301e-05	53.0	COG3655@1|root,COG3655@2|Bacteria,2GT6T@201174|Actinobacteria	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_960704_23	573413.Spirs_1713	7.511e-30	120.0	COG0234@1|root,COG0234@2|Bacteria,2J8BR@203691|Spirochaetes	203691|Spirochaetes	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
SX3_k127_960704_20	744872.Spica_0927	3.739e-37	149.0	29UU7@1|root,30G6P@2|Bacteria,2JB02@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_960704_9	889378.Spiaf_0599	1.436e-123	403.0	COG0568@1|root,COG0568@2|Bacteria,2J5M9@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086,ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
SX3_k127_960704_13	1307761.L21SP2_1262	9.504e-84	287.0	COG0210@1|root,COG0210@2|Bacteria,2J5T4@203691|Spirochaetes	203691|Spirochaetes	L	DNA helicase	pcrA	-	3.6.4.12	ko:K03656,ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
SX3_k127_965006_0	96561.Dole_3024	2.523e-15	90.0	COG3386@1|root,COG3391@1|root,COG4783@1|root,COG3386@2|Bacteria,COG3391@2|Bacteria,COG4783@2|Bacteria,1PE62@1224|Proteobacteria,43768@68525|delta/epsilon subdivisions,2X25C@28221|Deltaproteobacteria,2MP74@213118|Desulfobacterales	28221|Deltaproteobacteria	G	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_966451_0	744872.Spica_2840	7.285e-249	776.0	COG1523@1|root,COG1523@2|Bacteria,2J61K@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
SX3_k127_966451_7	1094980.Mpsy_0812	1.56e-108	376.0	COG3322@1|root,COG3920@1|root,arCOG02335@2157|Archaea,arCOG04446@2157|Archaea,2Y7UT@28890|Euryarchaeota,2NBMR@224756|Methanomicrobia	224756|Methanomicrobia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_2
SX3_k127_966451_11	768671.ThimaDRAFT_3225	3.332e-38	165.0	COG0745@1|root,COG2208@1|root,COG0745@2|Bacteria,COG2208@2|Bacteria,1N4K5@1224|Proteobacteria,1RNYP@1236|Gammaproteobacteria,1WZ01@135613|Chromatiales	135613|Chromatiales	KT	response regulator receiver	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Response_reg,SpoIIE
SX3_k127_966451_10	877455.Metbo_1144	3.81e-59	231.0	COG0784@1|root,arCOG06712@1|root,arCOG06537@2157|Archaea,arCOG06712@2157|Archaea,2XWYJ@28890|Euryarchaeota	28890|Euryarchaeota	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	PAS,PAS_4,PAS_9,PadR,Response_reg
SX3_k127_966451_9	555079.Toce_1868	2.296e-87	302.0	COG1473@1|root,COG1473@2|Bacteria,1TPD7@1239|Firmicutes,248AH@186801|Clostridia,42FAH@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM Peptidase M20	abgA	-	-	ko:K01436,ko:K12940	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
SX3_k127_966451_3	452637.Oter_1327	2.339e-125	407.0	COG0207@1|root,COG0207@2|Bacteria	2|Bacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
SX3_k127_966451_1	1499967.BAYZ01000146_gene6175	1.356e-189	606.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
SX3_k127_966451_5	1499967.BAYZ01000146_gene6176	3.805e-122	399.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	ko:K02025,ko:K15771	ko02010,map02010	M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
SX3_k127_966451_6	338969.Rfer_0952	3.687e-121	395.0	COG0395@1|root,COG0395@2|Bacteria,1MXTE@1224|Proteobacteria,2VZ7H@28216|Betaproteobacteria,4AJNY@80864|Comamonadaceae	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SX3_k127_966451_4	96561.Dole_0090	5.737e-123	406.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,42ME0@68525|delta/epsilon subdivisions,2WJB8@28221|Deltaproteobacteria,2MHR6@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
SX3_k127_966451_8	671143.DAMO_0331	1.38e-96	332.0	COG0263@1|root,COG0263@2|Bacteria,2NQMJ@2323|unclassified Bacteria	2|Bacteria	E	PUA domain	proB	GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3198	AA_kinase,PUA
SX3_k127_966451_2	278957.ABEA03000005_gene4380	1.681e-151	487.0	COG0407@1|root,COG0407@2|Bacteria,46WW7@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
SX3_k127_99480_2	452637.Oter_4115	5.761e-111	365.0	COG0650@1|root,COG0650@2|Bacteria	2|Bacteria	C	cellular response to DNA damage stimulus	echB	-	1.6.5.3	ko:K00337,ko:K14086,ko:K14087	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh,Proton_antipo_M,Proton_antipo_N
SX3_k127_99480_3	452637.Oter_4116	1.486e-99	346.0	COG3260@1|root,COG3260@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	echC	-	1.6.5.3	ko:K00331,ko:K14088,ko:K14105	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
SX3_k127_99480_6	509191.AEDB02000099_gene3939	3.51e-22	111.0	COG0852@1|root,COG0852@2|Bacteria,1VF7W@1239|Firmicutes,24R5W@186801|Clostridia,3WMFT@541000|Ruminococcaceae	186801|Clostridia	C	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	-	-	-	ko:K14089	-	-	-	-	ko00000	-	-	-	Complex1_30kDa
SX3_k127_99480_0	509191.AEDB02000099_gene3940	5.297e-157	503.0	COG3261@1|root,COG3261@2|Bacteria,1VZGX@1239|Firmicutes,248UJ@186801|Clostridia,3WHV8@541000|Ruminococcaceae	186801|Clostridia	C	Belongs to the complex I 49 kDa subunit family	-	-	1.6.5.3	ko:K00333,ko:K14090	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa,NiFeSe_Hases
SX3_k127_99480_5	1232410.KI421426_gene1502	7.71e-31	126.0	COG1143@1|root,COG1143@2|Bacteria,1RK71@1224|Proteobacteria,42VRE@68525|delta/epsilon subdivisions,2WS3F@28221|Deltaproteobacteria,43VQG@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K14091	-	-	-	-	ko00000	-	-	-	Fer4
SX3_k127_99480_4	504472.Slin_6046	7.419e-57	218.0	COG3653@1|root,COG3653@2|Bacteria,4NHDD@976|Bacteroidetes,47KC3@768503|Cytophagia	976|Bacteroidetes	Q	PFAM D-aminoacylase, C-terminal region	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
SX3_k127_99480_1	1499967.BAYZ01000131_gene368	1.89e-131	427.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,2NP16@2323|unclassified Bacteria	2|Bacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
## 3336 queries scanned
## Total time (seconds): 77.5121955871582
## Rate: 43.04 q/s