## Fri Nov 15 18:56:51 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin24/SX_3_bin.34.fa -m mmseqs --itype genome -o SX_3_bin.34 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/SX_3_bin.34 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
SX3_k127_1029474_3	673860.AciM339_0019	8.063e-16	91.0	COG0457@1|root,arCOG02493@1|root,arCOG02493@2157|Archaea,arCOG03038@2157|Archaea	2157|Archaea	KLT	Tetratricopeptide TPR_2 repeat protein	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	HTH_24,PQQ_2,PQQ_3,TPR_12,TPR_16,TPR_2,TPR_8
SX3_k127_1029474_1	1236689.MMALV_14300	6.726e-53	198.0	arCOG04990@1|root,arCOG04990@2157|Archaea,2XYVI@28890|Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function TPD sequence-motif	-	-	-	-	-	-	-	-	-	-	-	-	TPD
SX3_k127_1029474_2	335541.Swol_0642	5.534e-38	158.0	COG4359@1|root,COG4359@2|Bacteria,1TSZ9@1239|Firmicutes,24IHI@186801|Clostridia,42KRZ@68298|Syntrophomonadaceae	186801|Clostridia	E	Putative Phosphatase	mtnX	-	-	-	-	-	-	-	-	-	-	-	HAD,Put_Phosphatase
SX3_k127_1029474_0	744872.Spica_2136	5.264e-117	390.0	COG2211@1|root,COG2211@2|Bacteria	2|Bacteria	G	Major facilitator Superfamily	-	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1
SX3_k127_1029474_6	307480.IW16_07385	0.0009361	51.0	COG0382@1|root,COG0382@2|Bacteria,4NIRK@976|Bacteroidetes,1I86T@117743|Flavobacteriia,3ZUC1@59732|Chryseobacterium	976|Bacteroidetes	H	UbiA prenyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	UbiA
SX3_k127_1029474_4	1232410.KI421421_gene3533	7.953e-06	60.0	COG1361@1|root,COG4719@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4719@2|Bacteria,COG4932@2|Bacteria,1PFZK@1224|Proteobacteria,437DI@68525|delta/epsilon subdivisions,2X2JM@28221|Deltaproteobacteria,43VQS@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
SX3_k127_1104604_0	1499967.BAYZ01000153_gene1551	1.63e-58	227.0	COG2373@1|root,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,A2M_recep,CarboxypepD_reg,Plug,Thiol-ester_cl
SX3_k127_1135816_1	871968.DESME_07800	1.195e-73	267.0	COG0569@1|root,COG0569@2|Bacteria,1TPNS@1239|Firmicutes,24830@186801|Clostridia,260K8@186807|Peptococcaceae	186801|Clostridia	P	PFAM TrkA-N domain	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
SX3_k127_1135816_0	926692.AZYG01000086_gene724	3.125e-109	370.0	COG0168@1|root,COG0168@2|Bacteria,1TPAF@1239|Firmicutes,248K4@186801|Clostridia,3WB8J@53433|Halanaerobiales	186801|Clostridia	P	TIGRFAM potassium uptake protein, TrkH family	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
SX3_k127_1135816_5	439481.Aboo_0347	4.859e-07	63.0	arCOG02170@1|root,arCOG02170@2157|Archaea,2Y6ZT@28890|Euryarchaeota,3F310@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Domain of unknown function (DUF4129)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129
SX3_k127_1135816_4	439481.Aboo_0715	1.805e-33	136.0	arCOG02452@1|root,arCOG02452@2157|Archaea,2Y71S@28890|Euryarchaeota,3F36K@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	COG0467 RecA-superfamily ATPases implicated in signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1135816_2	693661.Arcve_1804	2.286e-60	221.0	COG2520@1|root,arCOG00033@2157|Archaea,2Y83R@28890|Euryarchaeota,245TI@183980|Archaeoglobi	183980|Archaeoglobi	J	S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe)	taw2	-	2.5.1.114	ko:K07055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Met_10
SX3_k127_1135816_3	1041930.Mtc_1643	1.691e-41	164.0	COG0644@1|root,arCOG00570@2157|Archaea,2XUI9@28890|Euryarchaeota,2N9DD@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,HI0933_like,Lycopene_cycl
SX3_k127_1210880_0	439481.Aboo_1103	8.313e-142	465.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,3F2ID@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	helicase superfamily c-terminal domain	hef	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,HHH_5,Helicase_C,ResIII
SX3_k127_1210880_3	1236689.MMALV_16200	5.323e-16	79.0	COG1383@1|root,arCOG01885@2157|Archaea,2Y07I@28890|Euryarchaeota,3F2V1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eS17 family	rps17e	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02962	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17e
SX3_k127_1210880_1	237368.SCABRO_03406	5.691e-73	260.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
SX3_k127_1210880_2	1094980.Mpsy_0245	3.262e-30	139.0	COG1819@1|root,arCOG01393@2157|Archaea,2XVXT@28890|Euryarchaeota,2N9X6@224756|Methanomicrobia	224756|Methanomicrobia	G	Glycosyltransferase family 28 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C,Glyco_trans_1_3
SX3_k127_121219_4	543526.Htur_1204	5.274e-07	57.0	arCOG01314@1|root,arCOG01314@2157|Archaea,2XVNC@28890|Euryarchaeota,23TF3@183963|Halobacteria	183963|Halobacteria	L	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF4350
SX3_k127_121219_0	572546.Arcpr_0382	1.747e-118	398.0	COG0174@1|root,arCOG01909@2157|Archaea,2XSYS@28890|Euryarchaeota,245NJ@183980|Archaeoglobi	183980|Archaeoglobi	E	glutamine synthetase	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
SX3_k127_121219_3	1227261.HMPREF0043_02220	1.05e-14	81.0	COG1522@1|root,COG1522@2|Bacteria,2HMNK@201174|Actinobacteria,4D7B3@85005|Actinomycetales	201174|Actinobacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_AsnC-type
SX3_k127_121219_1	589924.Ferp_1549	6.416e-77	274.0	COG0618@1|root,arCOG01566@2157|Archaea,2XT9H@28890|Euryarchaeota,245ZR@183980|Archaeoglobi	183980|Archaeoglobi	S	TrkA-N domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1,TrkA_N
SX3_k127_121219_2	387631.Asulf_01845	1.017e-75	283.0	COG1916@1|root,arCOG02142@2157|Archaea,2XTNE@28890|Euryarchaeota,24615@183980|Archaeoglobi	183980|Archaeoglobi	S	Pheromone shutdown protein	-	-	-	-	-	-	-	-	-	-	-	-	TraB
SX3_k127_1216139_0	243231.GSU2073	9.97e-34	149.0	COG3209@1|root,COG3227@1|root,COG3391@1|root,COG3209@2|Bacteria,COG3227@2|Bacteria,COG3391@2|Bacteria,1QW4H@1224|Proteobacteria	1224|Proteobacteria	M	Rhs Family	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Autotransporter,Big_3_2,Big_3_5,DUF4082,DUF4347,He_PIG,PT-HINT,RHS_repeat
SX3_k127_1216139_1	693661.Arcve_0149	1.746e-15	90.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,246Q2@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator, ArsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
SX3_k127_1230171_3	243231.GSU2073	7.663e-31	143.0	COG3209@1|root,COG3227@1|root,COG3391@1|root,COG3209@2|Bacteria,COG3227@2|Bacteria,COG3391@2|Bacteria,1QW4H@1224|Proteobacteria	1224|Proteobacteria	M	Rhs Family	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Autotransporter,Big_3_2,Big_3_5,DUF4082,DUF4347,He_PIG,PT-HINT,RHS_repeat
SX3_k127_1230171_2	314271.RB2654_06724	1.17e-63	250.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase,Cadherin,FG-GAP,Glyco_hydro_26,HemolysinCabind,Integrin_beta,Lipase_GDSL_2
SX3_k127_1230171_1	237368.SCABRO_01899	8.521e-67	246.0	COG0312@1|root,COG0312@2|Bacteria,2J2PJ@203682|Planctomycetes	203682|Planctomycetes	S	Putative modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
SX3_k127_1230171_4	529709.PYCH_07120	4.113e-27	126.0	COG0312@1|root,arCOG00322@2157|Archaea,2XVT5@28890|Euryarchaeota,2435V@183968|Thermococci	183968|Thermococci	S	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
SX3_k127_1230171_10	290512.Paes_0138	1.544e-14	83.0	COG3369@1|root,COG3369@2|Bacteria,1FFGC@1090|Chlorobi	1090|Chlorobi	S	SMART zinc finger CDGSH-type domain protein	-	-	-	-	-	-	-	-	-	-	-	-	zf-CDGSH
SX3_k127_1230171_7	1121904.ARBP01000010_gene2339	2.639e-23	109.0	COG3369@1|root,COG3369@2|Bacteria,4NW9E@976|Bacteroidetes,47W0Y@768503|Cytophagia	976|Bacteroidetes	S	Iron-binding zinc finger CDGSH type	-	-	-	-	-	-	-	-	-	-	-	-	zf-CDGSH
SX3_k127_1230171_9	8364.ENSXETP00000058485	2.503e-15	85.0	KOG4605@1|root,KOG4605@2759|Eukaryota,3A8Z4@33154|Opisthokonta,3CNFC@33208|Metazoa,3E4K8@33213|Bilateria,48EIW@7711|Chordata,49BIH@7742|Vertebrata	33208|Metazoa	S	CDGSH-type zinc finger. Function unknown.	CISD3	-	-	-	-	-	-	-	-	-	-	-	zf-CDGSH
SX3_k127_1230171_8	304371.MCP_0304	4.44e-19	93.0	COG2023@1|root,arCOG04345@2157|Archaea,2XYX0@28890|Euryarchaeota,2NA13@224756|Methanomicrobia	224756|Methanomicrobia	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp4	-	3.1.26.5	ko:K03540	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Rpr2
SX3_k127_1230171_0	1054217.TALC_01013	2.687e-72	248.0	COG2101@1|root,arCOG01764@2157|Archaea,2XTTR@28890|Euryarchaeota,241NQ@183967|Thermoplasmata	183967|Thermoplasmata	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	tbp	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
SX3_k127_1230171_5	368407.Memar_1919	3.93e-26	123.0	COG0561@1|root,arCOG01213@2157|Archaea,2XX94@28890|Euryarchaeota,2N9JY@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the dephosphorylation of 2-phosphoglycolate	-	-	3.1.3.18	ko:K22223	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	Hydrolase_3
SX3_k127_1230171_6	1480694.DC28_08820	3.141e-25	121.0	COG0248@1|root,COG0248@2|Bacteria,2J5XU@203691|Spirochaetes	203691|Spirochaetes	FP	Ppx GppA phosphatase family	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,Ppx-GppA
SX3_k127_1230171_11	443143.GM18_3269	1.465e-07	63.0	COG5607@1|root,COG5607@2|Bacteria,1NGVB@1224|Proteobacteria,42X7Z@68525|delta/epsilon subdivisions,2WSMB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	CHAD domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAD
SX3_k127_1252775_3	693661.Arcve_1491	7.542e-38	157.0	COG1541@1|root,arCOG02620@2157|Archaea,2XU3A@28890|Euryarchaeota,245U6@183980|Archaeoglobi	183980|Archaeoglobi	H	PFAM AMP-dependent synthetase	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
SX3_k127_1252775_2	410359.Pcal_0879	4.756e-89	305.0	COG0082@1|root,arCOG04133@2157|Archaea,2XQ0J@28889|Crenarchaeota	28889|Crenarchaeota	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
SX3_k127_1252775_4	429009.Adeg_1098	3.928e-24	104.0	2E32K@1|root,32Y2U@2|Bacteria,1VFFP@1239|Firmicutes,24RID@186801|Clostridia,42IMC@68295|Thermoanaerobacterales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1252775_0	909663.KI867150_gene247	7.225e-151	492.0	COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,42MB7@68525|delta/epsilon subdivisions,2WJVU@28221|Deltaproteobacteria,2MQ96@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SX3_k127_1252775_5	309800.C498_13178	0.0003144	53.0	COG0206@1|root,arCOG02202@2157|Archaea,2XTM7@28890|Euryarchaeota,23TEU@183963|Halobacteria	183963|Halobacteria	D	Involved in cell shape control	-	-	-	ko:K22222	-	-	-	-	ko00000,ko04812	-	-	-	Tubulin
SX3_k127_1252775_1	591019.Shell_1657	8.641e-95	325.0	COG5256@1|root,arCOG01561@2157|Archaea,2XPNT@28889|Crenarchaeota	28889|Crenarchaeota	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
SX3_k127_1256296_1	673860.AciM339_0142	3.201e-135	439.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,3F32D@33867|unclassified Euryarchaeota	28890|Euryarchaeota	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ1	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
SX3_k127_1256296_0	439481.Aboo_0964	1.567e-143	465.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,3F31W@33867|unclassified Euryarchaeota	28890|Euryarchaeota	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ1	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
SX3_k127_1256296_14	673860.AciM339_0143	6.1e-12	68.0	COG2443@1|root,arCOG02204@2157|Archaea,2Y6IU@28890|Euryarchaeota,3F2UZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	U	TIGRFAM protein translocase SEC61 complex gamma subunit	-	-	-	ko:K07342	ko03060,ko04141,ko04145,ko05110,map03060,map04141,map04145,map05110	M00401	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.7,3.A.5.8,3.A.5.9	-	-	-
SX3_k127_1256296_8	304371.MCP_2134	1.169e-41	159.0	COG0250@1|root,arCOG01920@2157|Archaea,2XWGQ@28890|Euryarchaeota,2N9MV@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcription elongation factor Spt5	spt5	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,Spt5-NGN
SX3_k127_1256296_6	868131.MSWAN_0394	9.61e-56	199.0	COG0080@1|root,arCOG04372@2157|Archaea,2XTJN@28890|Euryarchaeota,23NZG@183925|Methanobacteria	183925|Methanobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rpl11	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
SX3_k127_1256296_12	1303518.CCALI_01835	3.776e-17	91.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	usp-1	-	-	-	-	-	-	-	-	-	-	-	Usp
SX3_k127_1256296_3	1236689.MMALV_00490	1.535e-71	248.0	COG0081@1|root,arCOG04289@2157|Archaea,2XTJF@28890|Euryarchaeota,3F2IX@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Binds directly to 23S rRNA. Probably involved in E site tRNA release	rpl1	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
SX3_k127_1256296_4	1094980.Mpsy_1500	4.168e-68	241.0	COG0244@1|root,arCOG04288@2157|Archaea,2XU7C@28890|Euryarchaeota,2N993@224756|Methanomicrobia	224756|Methanomicrobia	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl10	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
SX3_k127_1256296_10	453591.Igni_0451	2.821e-21	97.0	COG2058@1|root,arCOG04287@2157|Archaea,2XQSC@28889|Crenarchaeota	28889|Crenarchaeota	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl12	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02869	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s
SX3_k127_1256296_13	673860.AciM339_0167	1.034e-16	84.0	arCOG05345@1|root,arCOG05345@2157|Archaea,2Y117@28890|Euryarchaeota,3F3G9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1256296_5	1094980.Mpsy_1158	1.083e-63	229.0	COG0122@1|root,arCOG00464@2157|Archaea,2XU5Y@28890|Euryarchaeota,2N9M2@224756|Methanomicrobia	224756|Methanomicrobia	L	8-oxoguanine DNA glycosylase domain protein	-	-	4.2.99.18	ko:K03660	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,OGG_N
SX3_k127_1256296_9	572546.Arcpr_0489	2.908e-24	113.0	COG1833@1|root,arCOG00463@2157|Archaea,2Y00K@28890|Euryarchaeota	28890|Euryarchaeota	L	SMART Excinuclease ABC, C subunit	nthB	-	-	-	-	-	-	-	-	-	-	-	DUF123
SX3_k127_1256296_16	797114.C475_01951	7.7e-05	55.0	COG1572@1|root,arCOG07561@1|root,arCOG02532@2157|Archaea,arCOG07561@2157|Archaea,2XZY0@28890|Euryarchaeota	28890|Euryarchaeota	S	CARDB	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,CarboxypepD_reg,PKD
SX3_k127_1256296_11	926569.ANT_15740	1.846e-20	100.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31
SX3_k127_1256296_2	926569.ANT_15720	3.035e-92	339.0	COG0535@1|root,COG0535@2|Bacteria,2G5XT@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Radical SAM domain protein	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
SX3_k127_1261368_1	880073.Calab_0825	2.446e-39	169.0	COG1404@1|root,COG3637@1|root,COG1404@2|Bacteria,COG3637@2|Bacteria,2NPDC@2323|unclassified Bacteria	2|Bacteria	O	Peptidase S8	-	-	3.4.21.66	ko:K08651	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	DUF3138,Peptidase_S8
SX3_k127_1261368_3	637905.SVI_0737	4.039e-09	68.0	COG0526@1|root,COG0526@2|Bacteria,1NCXZ@1224|Proteobacteria,1RZ3D@1236|Gammaproteobacteria,2QCHT@267890|Shewanellaceae	1236|Gammaproteobacteria	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
SX3_k127_1261368_2	797302.Halru_3004	3.51e-18	97.0	arCOG04522@1|root,arCOG04522@2157|Archaea,2XTU5@28890|Euryarchaeota,23U1D@183963|Halobacteria	183963|Halobacteria	O	cytochrome c biogenesis protein	dsbD	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
SX3_k127_1261368_0	1499967.BAYZ01000118_gene3290	2.117e-312	979.0	COG0058@1|root,COG0058@2|Bacteria,2NNZS@2323|unclassified Bacteria	2|Bacteria	G	Carbohydrate phosphorylase	malP	-	2.4.1.1,2.4.1.8	ko:K00688,ko:K00691	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R01555,R02111	RC00049	ko00000,ko00001,ko01000	-	GH65,GT35	-	DUF3417,Phosphorylase
SX3_k127_1304799_1	552811.Dehly_0729	6.006e-67	230.0	COG1908@1|root,COG1908@2|Bacteria	2|Bacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
SX3_k127_1304799_0	552811.Dehly_0726	5.011e-137	442.0	COG3259@1|root,COG3259@2|Bacteria,2G68W@200795|Chloroflexi,34CQT@301297|Dehalococcoidia	301297|Dehalococcoidia	C	hydrogenase large subunit	-	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
SX3_k127_1394603_1	269797.Mbar_A1866	7.071e-66	234.0	COG1712@1|root,arCOG00254@2157|Archaea,2XUNA@28890|Euryarchaeota,2NBJI@224756|Methanomicrobia	224756|Methanomicrobia	F	Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate	nadX	-	1.4.1.21	ko:K06989	ko00760,ko01100,map00760,map01100	-	R07407,R07410	RC02566	ko00000,ko00001,ko01000	-	-	-	DUF108,NAD_binding_3
SX3_k127_1394603_2	386456.JQKN01000001_gene1767	3.101e-58	211.0	COG0340@1|root,arCOG01940@2157|Archaea,2XSZ5@28890|Euryarchaeota,23P57@183925|Methanobacteria	183925|Methanobacteria	H	Biotin lipoate A B protein ligase	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
SX3_k127_1394603_0	634498.mru_1959	3.482e-107	362.0	COG0399@1|root,arCOG00118@2157|Archaea,2XTRQ@28890|Euryarchaeota,23NU5@183925|Methanobacteria	183925|Methanobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
SX3_k127_1425202_0	1210908.HSB1_15100	4.306e-54	205.0	COG0206@1|root,arCOG02201@2157|Archaea,2XSV8@28890|Euryarchaeota,23TS5@183963|Halobacteria	183963|Halobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ2	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
SX3_k127_1425202_1	673860.AciM339_0046	3.053e-10	61.0	COG0565@1|root,arCOG01018@2157|Archaea,2XUIY@28890|Euryarchaeota,3F2NC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	TIGRFAM RNA methyltransferase, TrmH family, group 1	trmH	-	-	ko:K02533	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
SX3_k127_1449916_2	1379698.RBG1_1C00001G0991	8.766e-27	126.0	COG2911@1|root,COG2931@1|root,COG4447@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG4447@2|Bacteria,2NR5X@2323|unclassified Bacteria	2|Bacteria	Q	FlgD Ig-like domain	-	-	3.2.1.136	ko:K15924	-	-	-	-	ko00000,ko01000	-	GH5	-	CBM_3,DUF1735,Laminin_G_3
SX3_k127_1449916_1	575540.Isop_0876	5.405e-31	142.0	COG2931@1|root,COG2931@2|Bacteria,2J1K0@203682|Planctomycetes	203682|Planctomycetes	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1449916_0	999630.TUZN_1426	7.922e-42	169.0	COG0622@1|root,arCOG01141@2157|Archaea,2XQUM@28889|Crenarchaeota	28889|Crenarchaeota	S	TIGRFAM phosphodiesterase, MJ0936 family	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
SX3_k127_1462240_6	338966.Ppro_2445	1.199e-07	67.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,CHU_C,Copper-bind,DUF1080,DUF11
SX3_k127_1462240_4	1191523.MROS_2005	8.641e-23	117.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1462240_3	493475.GARC_4265	1.561e-25	126.0	COG2931@1|root,COG2982@1|root,COG4733@1|root,COG2931@2|Bacteria,COG2982@2|Bacteria,COG4733@2|Bacteria,1MU7T@1224|Proteobacteria,1S1HJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Cadherin_3,DUF4214,DUF4347,He_PIG,HemolysinCabind,PATR,VCBS
SX3_k127_1462240_2	1089551.KE386572_gene1743	1.187e-25	126.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,2U12Y@28211|Alphaproteobacteria,4BRG6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
SX3_k127_1462240_1	1487953.JMKF01000004_gene680	1.237e-28	136.0	COG2931@1|root,COG2931@2|Bacteria,1G02E@1117|Cyanobacteria,1H9TQ@1150|Oscillatoriales	1117|Cyanobacteria	Q	Hemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,HemolysinCabind
SX3_k127_1462240_5	269797.Mbar_A3496	2.477e-09	67.0	arCOG09158@1|root,arCOG09158@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1462240_7	269797.Mbar_A3495	4.268e-06	58.0	arCOG08185@1|root,arCOG08185@2157|Archaea,2XYHN@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1462240_0	272624.lpg1269	4.088e-30	129.0	COG0553@1|root,COG0553@2|Bacteria,1NZWA@1224|Proteobacteria,1ST1F@1236|Gammaproteobacteria,1JEDK@118969|Legionellales	118969|Legionellales	KL	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	DUF4379
SX3_k127_1567968_0	1123288.SOV_3c05780	8.546e-36	154.0	COG0577@1|root,COG0577@2|Bacteria,1U388@1239|Firmicutes,4H32X@909932|Negativicutes	909932|Negativicutes	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX3_k127_1635141_4	523850.TON_0811	7.114e-14	78.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,2440W@183968|Thermococci	28890|Euryarchaeota	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24,HTH_5
SX3_k127_1635141_0	1094980.Mpsy_0983	9.582e-107	394.0	COG1404@1|root,arCOG02538@1|root,arCOG03439@1|root,arCOG00702@2157|Archaea,arCOG02538@2157|Archaea,arCOG03439@2157|Archaea,2XTGN@28890|Euryarchaeota,2N9WH@224756|Methanomicrobia	224756|Methanomicrobia	O	Subtilase family	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Calx-beta,Inhibitor_I9,Peptidase_S8
SX3_k127_1635141_2	706587.Desti_0745	3.558e-54	204.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,42R1T@68525|delta/epsilon subdivisions,2WN88@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Cysteine-rich domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_8
SX3_k127_1635141_1	706587.Desti_0010	7.406e-85	294.0	COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1QUMN@1224|Proteobacteria,43BMA@68525|delta/epsilon subdivisions,2X6ZG@28221|Deltaproteobacteria,2MR5E@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NAD(P)-binding Rossmann-like domain	hdrA	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,FlpD,Pyr_redox_2
SX3_k127_164999_2	386456.JQKN01000021_gene43	4.356e-53	192.0	COG0716@1|root,arCOG00519@2157|Archaea,2XXTN@28890|Euryarchaeota	28890|Euryarchaeota	C	Flavodoxin	-	GO:0000166,GO:0003674,GO:0003824,GO:0004729,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0010181,GO:0016491,GO:0016627,GO:0016634,GO:0016635,GO:0018130,GO:0019438,GO:0032553,GO:0033013,GO:0033014,GO:0034641,GO:0036094,GO:0042168,GO:0042440,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0070818,GO:0070819,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	-	-	-	-	-	-	-	-	-	Flavodoxin_3,Flavodoxin_5
SX3_k127_164999_4	926560.KE387023_gene1413	8.377e-11	73.0	COG3693@1|root,COG3828@1|root,COG3693@2|Bacteria,COG3828@2|Bacteria	2|Bacteria	N	Trehalose utilisation	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM9_1,CBM_2,CBM_3,CBM_4_9,CBM_6,Glyco_hydro_10,Glyco_hydro_48,Ricin_B_lectin,VCBS,fn3
SX3_k127_164999_5	272134.KB731325_gene618	4.513e-10	73.0	COG1572@1|root,COG2304@1|root,COG3209@1|root,COG3210@1|root,COG3420@1|root,COG1572@2|Bacteria,COG2304@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,COG3420@2|Bacteria,1G4UG@1117|Cyanobacteria	1117|Cyanobacteria	M	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG
SX3_k127_164999_6	28072.Nos7524_1685	2.402e-09	71.0	COG2304@1|root,COG3209@1|root,COG2304@2|Bacteria,COG3209@2|Bacteria,1GK47@1117|Cyanobacteria,1HT8F@1161|Nostocales	1117|Cyanobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
SX3_k127_164999_3	1236689.MMALV_06180	3.013e-48	183.0	arCOG01806@1|root,arCOG01806@2157|Archaea,2Y0PI@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ACT_7
SX3_k127_164999_0	401526.TcarDRAFT_1040	3.274e-107	360.0	COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,4H2Y8@909932|Negativicutes	909932|Negativicutes	E	acetylornithine aminotransferase	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SX3_k127_164999_1	339860.Msp_0550	1.818e-92	311.0	COG0548@1|root,arCOG00862@2157|Archaea,2XTW9@28890|Euryarchaeota,23NS3@183925|Methanobacteria	183925|Methanobacteria	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
SX3_k127_1668648_12	717606.PaecuDRAFT_2136	2.726e-45	190.0	COG1520@1|root,COG3210@1|root,COG4412@1|root,COG5276@1|root,COG5492@1|root,COG1520@2|Bacteria,COG3210@2|Bacteria,COG4412@2|Bacteria,COG5276@2|Bacteria,COG5492@2|Bacteria,1TR9M@1239|Firmicutes,4HEPP@91061|Bacilli,26T62@186822|Paenibacillaceae	91061|Bacilli	U	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Cadherin-like,Cohesin,Invasin_D3,SLH
SX3_k127_1668648_6	273116.14325665	1.208e-91	309.0	COG0863@1|root,arCOG00115@2157|Archaea,2Y1RZ@28890|Euryarchaeota,24231@183967|Thermoplasmata	183967|Thermoplasmata	L	DNA methylase	-	-	2.1.1.113,2.1.1.72	ko:K00571,ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
SX3_k127_1668648_27	456442.Mboo_1913	5.568e-05	52.0	COG1719@1|root,arCOG01688@2157|Archaea	2157|Archaea	K	PFAM 4-vinyl reductase, 4VR	-	-	-	ko:K07013	-	-	-	-	ko00000	-	-	-	DUF2507,V4R
SX3_k127_1668648_19	1128427.KB904821_gene2024	1.015e-30	128.0	COG1100@1|root,COG1100@2|Bacteria,1G5QQ@1117|Cyanobacteria,1HB5W@1150|Oscillatoriales	1117|Cyanobacteria	S	COG1100 GTPase SAR1 and related small G	-	-	-	-	-	-	-	-	-	-	-	-	Ras,Roc
SX3_k127_1668648_20	1094980.Mpsy_2611	6.202e-27	123.0	COG0745@1|root,arCOG02348@1|root,arCOG03799@1|root,arCOG02348@2157|Archaea,arCOG02592@2157|Archaea,arCOG03799@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF835)	-	-	2.7.7.65,6.3.4.2	ko:K01937,ko:K02488	ko00240,ko01100,ko02020,ko04112,map00240,map01100,map02020,map04112	M00052,M00511	R00571,R00573,R08057	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	DUF835,GAF_3,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
SX3_k127_1668648_18	326427.Cagg_2203	2.013e-31	130.0	COG1100@1|root,COG1100@2|Bacteria,2G9IC@200795|Chloroflexi,3777W@32061|Chloroflexia	32061|Chloroflexia	S	SMART Ras small GTPase, Ras type	-	-	-	-	-	-	-	-	-	-	-	-	Ras
SX3_k127_1668648_10	999630.TUZN_1739	3.8e-64	225.0	COG1838@1|root,arCOG04406@2157|Archaea,2XQ9V@28889|Crenarchaeota	28889|Crenarchaeota	C	Fe-S type, tartrate fumarate subfamily, beta	-	-	4.2.1.2,4.2.1.32	ko:K01678,ko:K03780	ko00020,ko00620,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00630,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00339,R01082	RC00443,RC01382	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
SX3_k127_1668648_3	304371.MCP_0509	5.031e-96	324.0	COG1951@1|root,arCOG04407@2157|Archaea,2XUQI@28890|Euryarchaeota,2N9FT@224756|Methanomicrobia	224756|Methanomicrobia	C	Fe-S type, tartrate fumarate subfamily, alpha	fumA	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
SX3_k127_1668648_11	195522.BD01_2000	1.733e-57	209.0	COG0463@1|root,arCOG00894@2157|Archaea,2XWXA@28890|Euryarchaeota,242RY@183968|Thermococci	183968|Thermococci	M	GtrA-like protein	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,GtrA
SX3_k127_1668648_25	273075.Ta0590a	1.248e-05	50.0	arCOG05340@1|root,arCOG05340@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1668648_21	237368.SCABRO_03564	9.029e-10	73.0	COG3291@1|root,COG3291@2|Bacteria,2J1GZ@203682|Planctomycetes	203682|Planctomycetes	U	PKD domain	-	-	-	-	-	-	-	-	-	-	-	-	PKD
SX3_k127_1668648_24	7739.XP_002592350.1	1.152e-06	63.0	29BDQ@1|root,2RIGR@2759|Eukaryota,39XEG@33154|Opisthokonta,3BY63@33208|Metazoa,3DE57@33213|Bilateria	33208|Metazoa	S	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF642,TSP_1
SX3_k127_1668648_4	1236689.MMALV_14500	4.111e-94	332.0	COG1304@1|root,arCOG00613@2157|Archaea,2XT6H@28890|Euryarchaeota,3F2I8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
SX3_k127_1668648_17	1236689.MMALV_14490	1.477e-33	150.0	COG1608@1|root,arCOG00860@2157|Archaea,2XSUI@28890|Euryarchaeota,3F2MV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids	argB1	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016114,GO:0016740,GO:0016772,GO:0016776,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0102043,GO:1901576	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
SX3_k127_1668648_7	439481.Aboo_0637	4.9e-90	324.0	COG0648@1|root,arCOG01894@2157|Archaea,2XU62@28890|Euryarchaeota,3F2J1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Xylose isomerase-like TIM barrel	-	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
SX3_k127_1668648_2	572546.Arcpr_0110	5.286e-107	357.0	COG1180@1|root,arCOG00947@2157|Archaea,2XWY1@28890|Euryarchaeota,246TQ@183980|Archaeoglobi	183980|Archaeoglobi	C	PFAM Radical SAM domain protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
SX3_k127_1668648_14	1042877.GQS_01545	2.154e-38	168.0	COG1305@1|root,arCOG02487@1|root,arCOG02169@2157|Archaea,arCOG02486@2157|Archaea,arCOG02487@2157|Archaea,2XU51@28890|Euryarchaeota,245KK@183968|Thermococci	183968|Thermococci	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
SX3_k127_1668648_23	1004149.AFOE01000009_gene2171	2.106e-07	65.0	COG2373@1|root,COG2373@2|Bacteria,4PKC4@976|Bacteroidetes	976|Bacteroidetes	J	this gene contains a nucleotide ambiguity which may be the result of a sequencing error	psrP1	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF11,SdrD_B,SprB
SX3_k127_1668648_5	1379698.RBG1_1C00001G0675	1.426e-92	317.0	COG1748@1|root,COG1748@2|Bacteria,2NPF8@2323|unclassified Bacteria	2|Bacteria	E	Saccharopine dehydrogenase C-terminal domain	lysDH	-	1.4.1.18	ko:K19064	ko00960,ko01100,ko01110,map00960,map01100,map01110	-	R00446,R02317	RC00062,RC00694	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,Sacchrp_dh_C,Sacchrp_dh_NADP
SX3_k127_1668648_8	1220534.B655_0942	4.261e-81	279.0	COG2041@1|root,arCOG00264@2157|Archaea,2XU2G@28890|Euryarchaeota	28890|Euryarchaeota	S	COG2041 Sulfite oxidase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
SX3_k127_1668648_26	306281.AJLK01000076_gene1003	2.928e-05	55.0	COG2885@1|root,COG2885@2|Bacteria,1G2YF@1117|Cyanobacteria,1JGWQ@1189|Stigonemataceae	1117|Cyanobacteria	M	OmpA family	-	-	-	ko:K02557,ko:K03286	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1,1.B.6	-	-	OmpA
SX3_k127_1668648_13	187272.Mlg_1313	2.079e-39	164.0	COG5621@1|root,COG5621@2|Bacteria,1MUVF@1224|Proteobacteria,1RZ65@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	secreted hydrolase	attH	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9
SX3_k127_1668648_29	269799.Gmet_1998	0.0004154	53.0	COG1305@1|root,COG1572@1|root,COG1305@2|Bacteria,COG1572@2|Bacteria,1NZT4@1224|Proteobacteria,4322D@68525|delta/epsilon subdivisions,2WWXW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Transglutaminase-like	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1668648_1	1499967.BAYZ01000013_gene6445	6.925e-138	451.0	COG1748@1|root,COG1748@2|Bacteria,2NNZ1@2323|unclassified Bacteria	2|Bacteria	E	Saccharopine dehydrogenase C-terminal domain	lys2	-	1.5.1.10	ko:K00293	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R02315	RC00215,RC00225	ko00000,ko00001,ko00002,ko01000	-	-	-	ELFV_dehydrog,Sacchrp_dh_C,Sacchrp_dh_NADP
SX3_k127_1668648_0	1047013.AQSP01000045_gene109	7.117e-150	486.0	COG0686@1|root,COG0686@2|Bacteria,2NNTE@2323|unclassified Bacteria	2|Bacteria	E	Alanine dehydrogenase/PNT, N-terminal domain	sdh	-	1.5.1.7,1.5.1.8,1.5.1.9	ko:K00290,ko:K14157	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715,R00716,R02313	RC00215,RC00217,RC00225,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
SX3_k127_1668648_28	6238.CBG08811	0.0001318	46.0	2EW74@1|root,2SY2K@2759|Eukaryota,3AVH6@33154|Opisthokonta,3C40D@33208|Metazoa,3DKPN@33213|Bilateria,40Q8N@6231|Nematoda,1M0JK@119089|Chromadorea,416DZ@6236|Rhabditida	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1668648_16	1408424.JHYI01000034_gene2398	1.238e-35	146.0	COG2013@1|root,COG2013@2|Bacteria,1TPN2@1239|Firmicutes,4H9P0@91061|Bacilli,1ZERN@1386|Bacillus	91061|Bacilli	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
SX3_k127_1668648_15	104355.XP_007870131.1	1.226e-36	144.0	2ECYW@1|root,2SIQI@2759|Eukaryota,3A1GD@33154|Opisthokonta,3P2GI@4751|Fungi	4751|Fungi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1668648_9	357808.RoseRS_3212	3.865e-71	248.0	COG0664@1|root,COG1136@1|root,COG0664@2|Bacteria,COG1136@2|Bacteria,2G6C9@200795|Chloroflexi,37685@32061|Chloroflexia	32061|Chloroflexia	V	ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,cNMP_binding
SX3_k127_1668648_22	796940.HMPREF9628_01162	1.847e-09	69.0	COG0577@1|root,COG0577@2|Bacteria,1TPHU@1239|Firmicutes,248RV@186801|Clostridia,25R6I@186804|Peptostreptococcaceae	186801|Clostridia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX3_k127_168965_7	696369.KI912183_gene2076	2.341e-25	113.0	COG2361@1|root,COG2361@2|Bacteria,1VFEB@1239|Firmicutes,24QN5@186801|Clostridia,2635X@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
SX3_k127_168965_6	192952.MM_2608	2.377e-26	111.0	COG1669@1|root,arCOG01206@2157|Archaea,2Y29X@28890|Euryarchaeota,2NBBA@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM DNA polymerase beta domain protein region	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
SX3_k127_168965_3	644281.MFS40622_0126	2.396e-85	295.0	COG1775@1|root,arCOG04464@2157|Archaea	2157|Archaea	E	PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	1.3.7.8	ko:K04113	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
SX3_k127_168965_2	1227497.C491_05201	3.94e-90	317.0	COG1574@1|root,arCOG00691@2157|Archaea,2XUUZ@28890|Euryarchaeota,23SFX@183963|Halobacteria	183963|Halobacteria	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
SX3_k127_168965_10	926562.Oweho_0579	0.0002769	54.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CHU_C,Laminin_G_3,MAM,PKD
SX3_k127_168965_9	1168034.FH5T_14275	0.0001501	55.0	COG1361@1|root,COG2866@1|root,COG4932@1|root,COG1361@2|Bacteria,COG2866@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF11,HYR
SX3_k127_168965_8	1236689.MMALV_07250	1.428e-14	81.0	arCOG02981@1|root,arCOG02981@2157|Archaea,2Y4VF@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_168965_4	1054217.TALC_00550	3.172e-75	267.0	COG0079@1|root,arCOG04273@2157|Archaea,2XTFZ@28890|Euryarchaeota,242D6@183967|Thermoplasmata	183967|Thermoplasmata	E	Aminotransferase class I and II	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
SX3_k127_168965_1	1094980.Mpsy_2683	7.565e-193	616.0	COG0172@1|root,arCOG00403@2157|Archaea,2XUK2@28890|Euryarchaeota,2N9B1@224756|Methanomicrobia	224756|Methanomicrobia	J	able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	-	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A2126	-
SX3_k127_168965_5	1094980.Mpsy_1303	3.796e-30	123.0	COG0526@1|root,arCOG01972@2157|Archaea,2XXRJ@28890|Euryarchaeota,2N9YG@224756|Methanomicrobia	224756|Methanomicrobia	O	Thioredoxin	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
SX3_k127_168965_11	208439.AJAP_22285	0.0004587	53.0	COG1572@1|root,COG1572@2|Bacteria,2H1Z9@201174|Actinobacteria,4E216@85010|Pseudonocardiales	201174|Actinobacteria	S	CARDB	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CARDB,F5_F8_type_C,Pectate_lyase_3
SX3_k127_168965_0	1094980.Mpsy_0259	0.0	1071.0	COG0060@1|root,arCOG00807@2157|Archaea,2XTIX@28890|Euryarchaeota,2N9A3@224756|Methanomicrobia	224756|Methanomicrobia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
SX3_k127_1710214_7	1268622.AVS7_04052	2.392e-16	90.0	COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,2VSIP@28216|Betaproteobacteria,4ADK5@80864|Comamonadaceae	28216|Betaproteobacteria	H	molybdopterin-guanine dinucleotide biosynthesis protein	mobB	-	-	ko:K03753	-	-	-	-	ko00000	-	-	-	MobB
SX3_k127_1710214_0	439481.Aboo_0289	3.935e-107	362.0	COG0303@1|root,arCOG00217@2157|Archaea,2XT2V@28890|Euryarchaeota,3F2ZG@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	TIGRFAM molybdenum cofactor synthesis domain	moeA2	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
SX3_k127_1710214_6	1485545.JQLW01000005_gene886	9.736e-24	116.0	COG0314@1|root,COG0314@2|Bacteria,1RGUX@1224|Proteobacteria	1224|Proteobacteria	H	Molybdopterin converting factor, large subunit	moaE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_1305,iEC042_1314.EC042_0869,iEC55989_1330.EC55989_0828,iECABU_c1320.ECABU_c08270,iECED1_1282.ECED1_0750,iECIAI1_1343.ECIAI1_0820,iECIAI39_1322.ECIAI39_0761,iECNA114_1301.ECNA114_0717,iECO103_1326.ECO103_0820,iECO111_1330.ECO111_0846,iECO26_1355.ECO26_0911,iECOK1_1307.ECOK1_0787,iECP_1309.ECP_0799,iECS88_1305.ECS88_0802,iECSE_1348.ECSE_0839,iECSF_1327.ECSF_0711,iECW_1372.ECW_m0841,iEKO11_1354.EKO11_3101,iEcE24377_1341.EcE24377A_0848,iG2583_1286.G2583_1013,iLF82_1304.LF82_1369,iNRG857_1313.NRG857_03500,iSSON_1240.SSON_0764,iUMN146_1321.UM146_13720,iUTI89_1310.UTI89_C0785,iWFL_1372.ECW_m0841,ic_1306.c0867	MoaE
SX3_k127_1710214_2	439481.Aboo_1203	1.23e-90	311.0	COG2896@1|root,arCOG00930@2157|Archaea,2XT7P@28890|Euryarchaeota,3F33B@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
SX3_k127_1710214_8	1463934.JOCF01000035_gene2420	0.0009031	51.0	COG4409@1|root,COG4409@2|Bacteria,2ID1A@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 8 (cellulase D) family	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1710214_1	456442.Mboo_1503	3.173e-92	307.0	COG0605@1|root,arCOG04147@2157|Archaea,2XUDD@28890|Euryarchaeota,2NAEN@224756|Methanomicrobia	224756|Methanomicrobia	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	-	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
SX3_k127_1710214_5	290315.Clim_2343	2.803e-47	181.0	COG0479@1|root,COG0479@2|Bacteria,1FDNF@1090|Chlorobi	1090|Chlorobi	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
SX3_k127_1710214_4	706587.Desti_0172	2.868e-74	259.0	COG2048@1|root,COG2048@2|Bacteria,1RC7G@1224|Proteobacteria,43B85@68525|delta/epsilon subdivisions,2WMVG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Heterodisulfide reductase subunit B	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
SX3_k127_1710214_3	156889.Mmc1_0430	3.909e-88	300.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2TQJA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
SX3_k127_1712884_1	324602.Caur_0392	1.598e-13	85.0	COG1361@1|root,COG1470@1|root,COG1361@2|Bacteria,COG1470@2|Bacteria,2GA7Y@200795|Chloroflexi,376PQ@32061|Chloroflexia	32061|Chloroflexia	M	SMART Parallel beta-helix repeat	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NPCBM_assoc
SX3_k127_1712884_0	192952.MM_3279	1.605e-171	551.0	COG1249@1|root,arCOG01068@2157|Archaea,2XTJE@28890|Euryarchaeota,2N9NV@224756|Methanomicrobia	224756|Methanomicrobia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
SX3_k127_1758471_1	1313301.AUGC01000010_gene929	1.28e-112	378.0	COG0205@1|root,COG0205@2|Bacteria,4NF8F@976|Bacteroidetes	976|Bacteroidetes	G	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
SX3_k127_1758471_0	96561.Dole_2226	1.444e-147	481.0	COG1362@1|root,COG1362@2|Bacteria,1NT1D@1224|Proteobacteria,42MN0@68525|delta/epsilon subdivisions,2WJ7P@28221|Deltaproteobacteria,2MIXW@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Aminopeptidase I zinc metalloprotease (M18)	apeA	-	3.4.11.21	ko:K01267	-	-	-	-	ko00000,ko01000,ko01002,ko04131	-	-	-	Peptidase_M18
SX3_k127_1758471_2	1459636.NTE_00635	1.346e-54	196.0	COG0163@1|root,arCOG01703@2157|Archaea,41SHU@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
SX3_k127_1758471_4	1146883.BLASA_0770	1.276e-18	102.0	COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria	201174|Actinobacteria	P	PFAM PKD domain containing protein	wcoG	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PKD
SX3_k127_1758471_5	566461.SSFG_01987	3.098e-10	73.0	COG1201@1|root,COG1201@2|Bacteria,2GJG3@201174|Actinobacteria	201174|Actinobacteria	L	dead DEAH box helicase	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,HTH_42,Helicase_C
SX3_k127_1758471_3	1094980.Mpsy_1230	5.694e-35	145.0	COG1467@1|root,arCOG04110@2157|Archaea,2XUZF@28890|Euryarchaeota,2N95F@224756|Methanomicrobia	224756|Methanomicrobia	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	-	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
SX3_k127_1782110_6	933262.AXAM01000056_gene3179	1.503e-17	83.0	COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1R68U@1224|Proteobacteria,42M71@68525|delta/epsilon subdivisions,2WKG0@28221|Deltaproteobacteria,2MJ02@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,FlpD
SX3_k127_1782110_0	335543.Sfum_1977	0.0	1062.0	COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MQTI@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,Pyr_redox_2
SX3_k127_1782110_4	697281.Mahau_0896	1.835e-51	189.0	COG1908@1|root,COG1908@2|Bacteria,1V7I6@1239|Firmicutes,24JV2@186801|Clostridia,42GG4@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
SX3_k127_1782110_5	1049564.TevJSym_az00230	3.844e-42	172.0	COG1035@1|root,COG4656@1|root,COG1035@2|Bacteria,COG4656@2|Bacteria,1NQN7@1224|Proteobacteria,1SM0M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus	-	-	-	-	-	-	-	-	-	-	-	-	FrhB_FdhB_C
SX3_k127_1782110_3	1121472.AQWN01000006_gene1789	2.557e-59	228.0	COG1150@1|root,COG1150@2|Bacteria,1UJJ4@1239|Firmicutes,25F45@186801|Clostridia,267CZ@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22,Fer4_4
SX3_k127_1782110_2	387631.Asulf_01820	1.227e-73	274.0	COG0543@1|root,arCOG02199@2157|Archaea,2XXQZ@28890|Euryarchaeota	28890|Euryarchaeota	C	Oxidoreductase NAD-binding domain	hydG	-	1.12.98.4	ko:K17995	ko00920,map00920	-	R10390	-	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
SX3_k127_1782110_1	386456.JQKN01000004_gene147	5.134e-84	296.0	COG0467@1|root,arCOG01171@2157|Archaea,2XXJX@28890|Euryarchaeota	28890|Euryarchaeota	T	KaiC	-	-	-	ko:K07331	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	ATPase
SX3_k127_1804242_3	767817.Desgi_0511	7.774e-30	119.0	COG1775@1|root,COG1775@2|Bacteria,1TS7H@1239|Firmicutes,2493U@186801|Clostridia,260S9@186807|Peptococcaceae	186801|Clostridia	E	Benzoyl-CoA reductase 2-hydroxyglutaryl-CoA dehydratase subunit, BcrC BadD HgdB	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
SX3_k127_1804242_0	1379698.RBG1_1C00001G0894	9.882e-171	544.0	COG1775@1|root,COG1775@2|Bacteria,2NRF8@2323|unclassified Bacteria	2|Bacteria	E	2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	1.3.7.8	ko:K04112	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
SX3_k127_1804242_2	644282.Deba_2802	7.974e-32	129.0	COG0454@1|root,COG0456@2|Bacteria,1N5FD@1224|Proteobacteria,42U24@68525|delta/epsilon subdivisions,2WQXQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SX3_k127_1804242_5	644282.Deba_2803	9.465e-17	81.0	2EQSX@1|root,33ICQ@2|Bacteria,1NMT6@1224|Proteobacteria,42XF7@68525|delta/epsilon subdivisions,2WT05@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Putative transposon-encoded protein (DUF2080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2080
SX3_k127_1804242_1	304371.MCP_2998	4.248e-114	394.0	COG1311@1|root,arCOG04455@2157|Archaea,2XSUG@28890|Euryarchaeota,2N96N@224756|Methanomicrobia	224756|Methanomicrobia	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polB	-	2.7.7.7	ko:K02323	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	DNA_pol_E_B,Metallophos,tRNA_anti-codon
SX3_k127_1804242_4	304371.MCP_0278	2.633e-22	97.0	COG2835@1|root,arCOG04124@2157|Archaea,2XZRS@28890|Euryarchaeota,2NA4S@224756|Methanomicrobia	224756|Methanomicrobia	S	Trm112p-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Trm112p
SX3_k127_1820090_6	926560.KE387023_gene1413	4.907e-15	91.0	COG3693@1|root,COG3828@1|root,COG3693@2|Bacteria,COG3828@2|Bacteria	2|Bacteria	N	Trehalose utilisation	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM9_1,CBM_2,CBM_3,CBM_4_9,CBM_6,Glyco_hydro_10,Glyco_hydro_48,Ricin_B_lectin,VCBS,fn3
SX3_k127_1820090_5	413816.BBJP01000010_gene649	9.547e-30	139.0	COG1520@1|root,arCOG02482@2157|Archaea,2XUI1@28890|Euryarchaeota,240TC@183963|Halobacteria	183963|Halobacteria	C	COG1520 FOG WD40-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
SX3_k127_1820090_7	246197.MXAN_5454	7.293e-09	70.0	COG0747@1|root,COG0747@2|Bacteria,1QX9G@1224|Proteobacteria,43C2P@68525|delta/epsilon subdivisions,2X7D9@28221|Deltaproteobacteria,2Z3FQ@29|Myxococcales	28221|Deltaproteobacteria	E	Fungalysin metallopeptidase (M36)	-	-	-	-	-	-	-	-	-	-	-	-	FTP,PA,Peptidase_M36,REJ
SX3_k127_1820090_8	99598.Cal7507_4267	2.76e-05	56.0	COG2319@1|root,COG3903@1|root,COG2319@2|Bacteria,COG3903@2|Bacteria,1FZVW@1117|Cyanobacteria	1117|Cyanobacteria	A	WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	NB-ARC,Pentapeptide,WD40
SX3_k127_1820090_1	304371.MCP_0726	2.83e-55	203.0	COG0030@1|root,arCOG04131@2157|Archaea,2XU1Q@28890|Euryarchaeota,2N9HP@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
SX3_k127_1820090_0	1236689.MMALV_03220	1.434e-62	222.0	COG1601@1|root,COG3269@1|root,arCOG01640@2157|Archaea,arCOG01641@2157|Archaea,2XTVZ@28890|Euryarchaeota,3F2N9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2b	-	-	ko:K03238	ko03013,map03013	-	-	-	ko00000,ko00001,ko01009,ko03012	-	-	-	TRAM,eIF-5_eIF-2B
SX3_k127_1820090_2	351160.RCIX1020	2.534e-47	189.0	COG3389@1|root,arCOG04463@2157|Archaea,2XSZT@28890|Euryarchaeota,2N9I2@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART Peptidase A22, presenilin signal peptide	-	-	-	-	-	-	-	-	-	-	-	-	SPP
SX3_k127_1820090_4	439481.Aboo_1372	2.506e-34	140.0	COG2129@1|root,arCOG01145@2157|Archaea,2XXMZ@28890|Euryarchaeota,3F2QR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Metallophosphoesterase, calcineurin superfamily	-	-	-	ko:K07096	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
SX3_k127_1820090_3	673860.AciM339_0412	6.07e-42	160.0	COG1437@1|root,arCOG01723@2157|Archaea,2XYQS@28890|Euryarchaeota,3F3BY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	TIGRFAM adenylyl cyclase CyaB	cyaB	GO:0003674,GO:0003824,GO:0004016,GO:0009975,GO:0016829,GO:0016849	4.6.1.1	ko:K05873	ko00230,map00230	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	CYTH
SX3_k127_1835421_1	414684.RC1_3822	5.408e-47	195.0	COG3898@1|root,COG3898@2|Bacteria,1R052@1224|Proteobacteria	1224|Proteobacteria	S	HemY domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1835421_4	269797.Mbar_A0751	2.732e-10	74.0	COG5306@1|root,arCOG03508@2157|Archaea,2Y0JV@28890|Euryarchaeota,2NAN5@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF2341)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2341
SX3_k127_1835421_5	1244869.H261_03793	2.373e-05	52.0	COG4251@1|root,COG4251@2|Bacteria,1R2Y7@1224|Proteobacteria,2TZTF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_9
SX3_k127_1835421_2	502025.Hoch_5817	3.834e-19	101.0	COG1716@1|root,COG1716@2|Bacteria,1PYHH@1224|Proteobacteria,43DZM@68525|delta/epsilon subdivisions,2WZA1@28221|Deltaproteobacteria,2Z1P6@29|Myxococcales	28221|Deltaproteobacteria	T	Clostripain family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C11
SX3_k127_1835421_3	1242864.D187_006939	3.179e-13	83.0	COG4870@1|root,COG4870@2|Bacteria,1N9HX@1224|Proteobacteria	1224|Proteobacteria	O	Belongs to the peptidase C1 family	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1874350_6	316274.Haur_3105	1.98e-22	114.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	scpD	-	3.4.17.18	ko:K05996	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	P_proprotein,Peptidase_M14
SX3_k127_1874350_7	1265505.ATUG01000001_gene3021	8.353e-10	72.0	COG1404@1|root,COG3291@1|root,COG4870@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,COG4870@2|Bacteria,1N8Z7@1224|Proteobacteria,43AX0@68525|delta/epsilon subdivisions,2X6B7@28221|Deltaproteobacteria,2MPH8@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Papain family cysteine protease	-	-	-	-	-	-	-	-	-	-	-	-	PKD,Peptidase_C1
SX3_k127_1874350_4	471854.Dfer_3145	3.679e-39	169.0	COG2931@1|root,COG2931@2|Bacteria,4NKIR@976|Bacteroidetes,47S7V@768503|Cytophagia	976|Bacteroidetes	Q	SMART Integrin alpha beta-propellor repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,FG-GAP,HYR,VCBS
SX3_k127_1874350_5	28072.Nos7524_5484	1.838e-28	134.0	COG2304@1|root,COG3209@1|root,COG3210@1|root,COG3266@1|root,COG5276@1|root,COG2304@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,COG3266@2|Bacteria,COG5276@2|Bacteria,1G4UG@1117|Cyanobacteria	1117|Cyanobacteria	M	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,RHS_repeat
SX3_k127_1874350_2	264462.Bd3234	5.504e-56	219.0	COG2866@1|root,COG2866@2|Bacteria,1MZYN@1224|Proteobacteria,42PTT@68525|delta/epsilon subdivisions,2MT5U@213481|Bdellovibrionales,2WS13@28221|Deltaproteobacteria	213481|Bdellovibrionales	M	Zn_pept	-	-	3.4.17.18	ko:K05996	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M14
SX3_k127_1874350_0	304371.MCP_1816	4.686e-160	522.0	COG1602@1|root,arCOG04269@2157|Archaea,2XTEQ@28890|Euryarchaeota,2NADJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Pfam:DUF650	-	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
SX3_k127_1874350_3	399550.Smar_1316	6.363e-48	183.0	COG1573@1|root,arCOG00905@2157|Archaea,2XQ7T@28889|Crenarchaeota	28889|Crenarchaeota	L	TIGRFAM phage SPO1 DNA polymerase-related protein	-	GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
SX3_k127_1874350_1	304371.MCP_1815	2.771e-72	252.0	COG1533@1|root,arCOG01290@2157|Archaea,2XY2A@28890|Euryarchaeota,2N9Z2@224756|Methanomicrobia	224756|Methanomicrobia	L	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SX3_k127_1874807_0	755731.Clo1100_1725	1.634e-38	166.0	COG3391@1|root,COG4733@1|root,COG3391@2|Bacteria,COG4733@2|Bacteria,1UEBB@1239|Firmicutes,24DIX@186801|Clostridia,36HNU@31979|Clostridiaceae	186801|Clostridia	N	PFAM Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1885405_0	316067.Geob_2986	5.69e-32	144.0	COG1404@1|root,COG1572@1|root,COG1404@2|Bacteria,COG1572@2|Bacteria,1REF1@1224|Proteobacteria,42RS0@68525|delta/epsilon subdivisions,2WNDK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,Peptidase_S8
SX3_k127_1891473_0	1333523.L593_11785	9.545e-90	305.0	COG1131@1|root,arCOG00196@2157|Archaea,2Y7KH@28890|Euryarchaeota,240TI@183963|Halobacteria	28890|Euryarchaeota	E	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SX3_k127_1891473_1	1333523.L593_11780	2.208e-87	300.0	COG1277@1|root,arCOG02440@2157|Archaea,2XX79@28890|Euryarchaeota,23TG0@183963|Halobacteria	183963|Halobacteria	S	COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component	-	-	-	ko:K01992,ko:K19341	ko02010,map02010	M00254,M00762	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.132.2	-	-	ABC2_membrane_2
SX3_k127_1893484_0	1197130.BAFM01000012_gene2173	1.358e-09	71.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWHT@28890|Euryarchaeota,23V64@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	gntR	-	-	-	-	-	-	-	-	-	-	-	HTH_24,HTH_5,MarR_2
SX3_k127_1896880_9	1200567.JNKD01000002_gene2261	2.485e-10	74.0	COG0366@1|root,COG3291@1|root,COG0366@2|Bacteria,COG3291@2|Bacteria,1MU90@1224|Proteobacteria,1RQ1S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	alpha-amylase	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,CBM26,CHB_HEX_C_1,PKD
SX3_k127_1896880_10	1968.JOEV01000013_gene889	9.733e-06	59.0	COG1073@1|root,COG2273@1|root,COG1073@2|Bacteria,COG2273@2|Bacteria,2GKFN@201174|Actinobacteria	201174|Actinobacteria	G	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,Glyco_hydro_64
SX3_k127_1896880_5	886377.Murru_2329	3.374e-39	168.0	COG3055@1|root,COG3291@1|root,COG3055@2|Bacteria,COG3291@2|Bacteria,4NHHD@976|Bacteroidetes,1HWPE@117743|Flavobacteriia	976|Bacteroidetes	M	Di-glucose binding within endoplasmic reticulum	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,Kelch_1,Kelch_6,Malectin,PKD
SX3_k127_1896880_6	1457250.BBMO01000001_gene1581	1.786e-32	147.0	COG3291@1|root,arCOG02526@1|root,arCOG03499@1|root,arCOG02508@2157|Archaea,arCOG02510@2157|Archaea,arCOG02526@2157|Archaea,arCOG03499@2157|Archaea,2XUY6@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,PKD,Pilin_N,SdrD_B
SX3_k127_1896880_2	644281.MFS40622_0392	6.339e-69	244.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,23Q49@183939|Methanococci	183939|Methanococci	J	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
SX3_k127_1896880_4	456442.Mboo_1975	5.496e-41	159.0	COG0009@1|root,arCOG01952@2157|Archaea,2XVGC@28890|Euryarchaeota,2N9VK@224756|Methanomicrobia	224756|Methanomicrobia	J	TIGRFAM Sua5 YciO YrdC YwlC family protein	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
SX3_k127_1896880_3	192952.MM_2083	7.593e-66	237.0	COG0284@1|root,arCOG00081@2157|Archaea,2XU66@28890|Euryarchaeota,2N9J4@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0060	OMPdecase
SX3_k127_1896880_1	439481.Aboo_1389	1.12e-168	541.0	COG0034@1|root,arCOG00093@2157|Archaea,2XSWJ@28890|Euryarchaeota,3F2FP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
SX3_k127_1896880_8	634498.mru_1281	3.174e-18	85.0	COG2126@1|root,arCOG04126@2157|Archaea,2XZUV@28890|Euryarchaeota,23P7A@183925|Methanobacteria	183925|Methanobacteria	J	binds to the 23S rRNA	rpl37e	-	-	ko:K02922	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37e
SX3_k127_1896880_7	439481.Aboo_1391	7.601e-24	102.0	COG1958@1|root,arCOG00998@2157|Archaea,2XZTF@28890|Euryarchaeota,3F2SB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	snRNP Sm proteins	lsm	GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
SX3_k127_1896880_0	673860.AciM339_1269	1.883e-263	837.0	COG0417@1|root,arCOG00328@2157|Archaea,2XU1K@28890|Euryarchaeota,3F2F0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	DNA polymerase type-B family	polB1	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1,Intein_splicing
SX3_k127_1912733_6	938288.HG326226_gene697	1.043e-53	196.0	COG0563@1|root,COG0563@2|Bacteria,1TP27@1239|Firmicutes,247YN@186801|Clostridia,268PU@186813|unclassified Clostridiales	186801|Clostridia	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS20110	ADK,ADK_lid
SX3_k127_1912733_9	717606.PaecuDRAFT_2136	1.596e-36	160.0	COG1520@1|root,COG3210@1|root,COG4412@1|root,COG5276@1|root,COG5492@1|root,COG1520@2|Bacteria,COG3210@2|Bacteria,COG4412@2|Bacteria,COG5276@2|Bacteria,COG5492@2|Bacteria,1TR9M@1239|Firmicutes,4HEPP@91061|Bacilli,26T62@186822|Paenibacillaceae	91061|Bacilli	U	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Cadherin-like,Cohesin,Invasin_D3,SLH
SX3_k127_1912733_2	1459636.NTE_01035	2.747e-72	256.0	COG0640@1|root,COG1809@1|root,arCOG00394@2157|Archaea,arCOG04896@2157|Archaea	2157|Archaea	K	PFAM (2R)-phospho-3-sulfolactate synthase ComA	comA	GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0050545	4.4.1.19	ko:K08097	ko00680,ko01120,map00680,map01120	M00358	R07476	RC01799	ko00000,ko00001,ko00002,ko01000	-	-	-	ComA
SX3_k127_1912733_0	485913.Krac_2851	1.439e-107	362.0	COG0715@1|root,COG0715@2|Bacteria,2G7DP@200795|Chloroflexi	200795|Chloroflexi	P	TIGRFAM aliphatic sulfonates family ABC transporter, periplsmic ligand-binding protein	-	-	-	ko:K02051,ko:K15553	ko00920,ko02010,map00920,map02010	M00188,M00436	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.2	-	-	NMT1,NMT1_2
SX3_k127_1912733_1	292459.STH874	2.828e-75	262.0	COG1116@1|root,COG1116@2|Bacteria,1TRM6@1239|Firmicutes,248CG@186801|Clostridia	186801|Clostridia	P	ABC-type nitrate sulfonate bicarbonate transport system ATPase component	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
SX3_k127_1912733_3	765420.OSCT_2147	3.644e-67	244.0	COG0600@1|root,COG0600@2|Bacteria,2G837@200795|Chloroflexi	200795|Chloroflexi	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
SX3_k127_1912733_7	330214.NIDE0992	1.087e-50	191.0	COG1039@1|root,COG1039@2|Bacteria	2|Bacteria	L	RNA-DNA hybrid ribonuclease activity	rnhC	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03471	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DUF3378,RNase_HII
SX3_k127_1912733_10	525904.Tter_0250	3.875e-32	135.0	COG4328@1|root,COG4328@2|Bacteria	2|Bacteria	Q	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF429,RelA_SpoT
SX3_k127_1912733_11	351160.RCIX1716	2.429e-31	139.0	COG3174@1|root,arCOG04203@2157|Archaea,2XT0W@28890|Euryarchaeota,2N9ST@224756|Methanomicrobia	224756|Methanomicrobia	P	MgtC family	-	-	-	-	-	-	-	-	-	-	-	-	DUF4010,MgtC
SX3_k127_1912733_8	926550.CLDAP_28830	1.916e-45	168.0	COG5485@1|root,COG5485@2|Bacteria	2|Bacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
SX3_k127_1912733_12	163908.KB235896_gene30	6.296e-13	83.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,HemolysinCabind,VCBS
SX3_k127_1912733_4	1089553.Tph_c10180	9.203e-65	232.0	COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,247KQ@186801|Clostridia,42EWQ@68295|Thermoanaerobacterales	186801|Clostridia	F	Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage	mtaP	-	2.4.2.1,2.4.2.28	ko:K00772,ko:K03783	ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110	M00034	R01402,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
SX3_k127_1912733_5	1054217.TALC_01547	1.235e-59	223.0	COG0648@1|root,arCOG01894@2157|Archaea,2XU62@28890|Euryarchaeota	28890|Euryarchaeota	G	PFAM Xylose isomerase domain protein TIM barrel	nfo	GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
SX3_k127_1919716_10	643648.Slip_1398	0.0005066	51.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
SX3_k127_1919716_9	4565.Traes_7DL_B5EC8653A.1	0.0004585	44.0	COG2124@1|root,KOG0157@2759|Eukaryota,37IK4@33090|Viridiplantae,3G7CM@35493|Streptophyta,3KMBC@4447|Liliopsida,3ICKS@38820|Poales	35493|Streptophyta	Q	Belongs to the cytochrome P450 family	-	GO:0000038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006725,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009698,GO:0009699,GO:0009987,GO:0010345,GO:0012505,GO:0016053,GO:0019438,GO:0019748,GO:0019752,GO:0032787,GO:0042761,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046394,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901576	-	ko:K15402	ko00073,map00073	-	R09454	RC00797	ko00000,ko00001,ko00199,ko01000	-	-	-	p450
SX3_k127_1919716_3	1499967.BAYZ01000152_gene1432	2.832e-62	224.0	COG1131@1|root,COG1131@2|Bacteria,2NPDQ@2323|unclassified Bacteria	2|Bacteria	V	ATPases associated with a variety of cellular activities	natA2	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_1919716_2	1236689.MMALV_01750	8.412e-64	230.0	COG0157@1|root,arCOG01482@2157|Archaea,2XTTY@28890|Euryarchaeota,3F2NB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Involved in the catabolism of quinolinic acid (QA)	nadC	GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034213,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1867	QRPTase_C,QRPTase_N
SX3_k127_1919716_1	304371.MCP_2914	3.848e-107	383.0	COG1033@1|root,COG2409@1|root,arCOG02174@2157|Archaea,arCOG02175@2157|Archaea,2XVKJ@28890|Euryarchaeota	28890|Euryarchaeota	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
SX3_k127_1919716_4	1054217.TALC_00149	1.192e-55	205.0	COG2519@1|root,arCOG00978@2157|Archaea,2XTV7@28890|Euryarchaeota,241UX@183967|Thermoplasmata	183967|Thermoplasmata	J	tRNA methyltransferase complex GCD14 subunit	-	-	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14
SX3_k127_1919716_0	439481.Aboo_0942	3.667e-217	688.0	COG0532@1|root,arCOG01560@2157|Archaea,2XU09@28890|Euryarchaeota,3F2FJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D4,IF-2,Intein_splicing,LAGLIDADG_3
SX3_k127_1919716_8	565033.GACE_1329	2.477e-22	96.0	COG2075@1|root,arCOG01950@2157|Archaea,2Y00Q@28890|Euryarchaeota,246HX@183980|Archaeoglobi	183980|Archaeoglobi	J	Binds to the 23S rRNA	rpl24e	-	-	ko:K02896	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L24e
SX3_k127_1919716_7	1054217.TALC_00113	8.672e-28	114.0	COG2053@1|root,arCOG04314@2157|Archaea,2XYMV@28890|Euryarchaeota,241VA@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the eukaryotic ribosomal protein eS28 family	rps28e	-	-	ko:K02979	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S28e
SX3_k127_1919716_5	1343739.PAP_04680	6.793e-47	171.0	COG1358@1|root,arCOG01751@2157|Archaea,2XX4C@28890|Euryarchaeota,2444W@183968|Thermococci	183968|Thermococci	J	Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs	rpl7ae	GO:0000470,GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02936	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03009,ko03011	-	-	-	Ribosomal_L7Ae
SX3_k127_1919716_6	1454010.JEOE01000015_gene1130	2.645e-29	123.0	COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria	201174|Actinobacteria	P	PFAM PKD domain containing protein	wcoG	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PKD
SX3_k127_1931483_1	269797.Mbar_A3402	6.587e-123	411.0	COG1008@1|root,arCOG01538@2157|Archaea,2XTP0@28890|Euryarchaeota,2NAFX@224756|Methanomicrobia	224756|Methanomicrobia	C	Proton-conducting membrane transporter	-	-	1.5.98.3	ko:K22168	-	-	-	-	ko00000,ko01000	3.D.9.1	-	-	Proton_antipo_M
SX3_k127_1931483_0	192952.MM_2480	1.457e-134	444.0	COG1007@1|root,arCOG01540@2157|Archaea,2XSY7@28890|Euryarchaeota,2N9SZ@224756|Methanomicrobia	224756|Methanomicrobia	C	Proton-conducting membrane transporter	-	-	1.5.98.3	ko:K22169	-	-	-	-	ko00000,ko01000	3.D.9.1	-	iAF692.Mbar_A3401	Proton_antipo_M
SX3_k127_1931483_15	331678.Cphamn1_0596	2.622e-09	63.0	COG1826@1|root,COG1826@2|Bacteria,1FE6Y@1090|Chlorobi	1090|Chlorobi	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
SX3_k127_1931483_6	1379698.RBG1_1C00001G1133	1.306e-67	244.0	COG1575@1|root,COG1575@2|Bacteria,2NPNN@2323|unclassified Bacteria	2|Bacteria	H	UbiA prenyltransferase family	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
SX3_k127_1931483_14	273116.14324590	1.918e-13	73.0	COG1826@1|root,arCOG02694@2157|Archaea,2Y23W@28890|Euryarchaeota,242BR@183967|Thermoplasmata	183967|Thermoplasmata	U	mttA/Hcf106 family	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
SX3_k127_1931483_8	1459636.NTE_00826	1.069e-55	209.0	COG0805@1|root,arCOG01919@2157|Archaea,41S69@651137|Thaumarchaeota	651137|Thaumarchaeota	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
SX3_k127_1931483_10	228405.HNE_0678	2.029e-49	188.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,2TSDZ@28211|Alphaproteobacteria,43X83@69657|Hyphomonadaceae	28211|Alphaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispB	GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
SX3_k127_1931483_4	368407.Memar_1711	1.592e-76	270.0	COG0644@1|root,arCOG00570@2157|Archaea,2XWXQ@28890|Euryarchaeota,2N9RD@224756|Methanomicrobia	224756|Methanomicrobia	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
SX3_k127_1931483_3	756499.Desde_0778	7.369e-85	295.0	COG0247@1|root,COG0247@2|Bacteria,1TPG1@1239|Firmicutes,24HJC@186801|Clostridia,264WD@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_10,Fer4_8
SX3_k127_1931483_2	1236689.MMALV_04150	2.457e-105	372.0	COG0277@1|root,arCOG00337@2157|Archaea,arCOG00340@2157|Archaea,2XVP5@28890|Euryarchaeota	28890|Euryarchaeota	C	FAD binding domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17
SX3_k127_1931483_13	479437.Elen_0482	4.397e-16	92.0	COG1146@1|root,COG1148@1|root,COG1146@2|Bacteria,COG1148@2|Bacteria,2HVPE@201174|Actinobacteria,4CX7M@84998|Coriobacteriia	84998|Coriobacteriia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4
SX3_k127_1931483_9	373903.Hore_15950	9.668e-53	192.0	COG0778@1|root,COG0778@2|Bacteria,1V49Q@1239|Firmicutes,24IH8@186801|Clostridia	186801|Clostridia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SX3_k127_1931483_7	604354.TSIB_1900	2.98e-56	203.0	COG1225@1|root,arCOG00310@2157|Archaea,2XY0E@28890|Euryarchaeota,2440M@183968|Thermococci	183968|Thermococci	O	SCO1/SenC	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
SX3_k127_1931483_11	909663.KI867150_gene1862	8.38e-38	145.0	COG1917@1|root,COG1917@2|Bacteria,1RJX2@1224|Proteobacteria,42TVK@68525|delta/epsilon subdivisions,2WQ2T@28221|Deltaproteobacteria,2MQJ4@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SX3_k127_1931483_16	926690.KE386573_gene1785	5.566e-08	63.0	arCOG02452@1|root,arCOG02452@2157|Archaea,2XYB9@28890|Euryarchaeota,23UGR@183963|Halobacteria	183963|Halobacteria	S	COG0467 RecA-superfamily ATPases implicated in signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_1931483_5	693661.Arcve_1631	2.533e-76	272.0	COG0467@1|root,COG2229@1|root,arCOG00362@2157|Archaea,arCOG01171@2157|Archaea,2XXH5@28890|Euryarchaeota	28890|Euryarchaeota	T	small GTP-binding protein	-	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	ATPase,Arf,Robl_LC7
SX3_k127_1931483_12	1487923.DP73_04955	2.603e-24	109.0	COG0467@1|root,COG0467@2|Bacteria,1TSIM@1239|Firmicutes,24DRY@186801|Clostridia,260SN@186807|Peptococcaceae	186801|Clostridia	T	KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
SX3_k127_1939818_0	439481.Aboo_0043	5.475e-49	183.0	COG0565@1|root,arCOG01018@2157|Archaea,2XUIY@28890|Euryarchaeota,3F2NC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	TIGRFAM RNA methyltransferase, TrmH family, group 1	trmH	-	-	ko:K02533	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
SX3_k127_1939818_1	673860.AciM339_1093	1.046e-45	175.0	COG0101@1|root,arCOG04449@2157|Archaea,2XTH5@28890|Euryarchaeota,3F2TH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	iAF692.Mbar_A1332	PseudoU_synth_1
SX3_k127_1952307_2	552811.Dehly_0725	2.995e-31	132.0	COG0680@1|root,COG0680@2|Bacteria,2GANP@200795|Chloroflexi,34CW5@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Hydrogenase maturation protease	-	-	-	ko:K00442	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001	-	-	-	HycI
SX3_k127_1952307_1	314271.RB2654_06439	1.859e-65	256.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase,Cadherin,FG-GAP,Glyco_hydro_26,HemolysinCabind,Integrin_beta,Lipase_GDSL_2
SX3_k127_1952307_3	82654.Pse7367_2629	1.615e-29	138.0	COG3209@1|root,COG3210@1|root,COG3209@2|Bacteria,COG3210@2|Bacteria,1G4PY@1117|Cyanobacteria,1HEZB@1150|Oscillatoriales	1117|Cyanobacteria	M	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
SX3_k127_1952307_5	485914.Hmuk_0348	5.238e-05	57.0	COG3398@1|root,arCOG02611@2157|Archaea,2XX30@28890|Euryarchaeota,23VMW@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24,HTH_5
SX3_k127_1952307_0	113355.CM001775_gene1664	2.457e-105	359.0	COG1404@1|root,COG2931@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria,1G32M@1117|Cyanobacteria	1117|Cyanobacteria	Q	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	PPC,VCBS
SX3_k127_1952307_4	760568.Desku_2791	1.09e-11	77.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	CBM_6,CotH,F5_F8_type_C,Glyco_hydro_16,Glyco_hydro_cc,LRR_5,PKD
SX3_k127_1959513_0	697281.Mahau_2307	9.688e-93	317.0	COG1145@1|root,COG2006@1|root,COG1145@2|Bacteria,COG2006@2|Bacteria,1TRX2@1239|Firmicutes,249GX@186801|Clostridia,42F8W@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Fer4_10,Fer4_7
SX3_k127_1983871_2	215803.DB30_3947	2.302e-14	88.0	COG3509@1|root,COG3509@2|Bacteria,1MXUI@1224|Proteobacteria,430Q8@68525|delta/epsilon subdivisions,2WVYQ@28221|Deltaproteobacteria,2YU06@29|Myxococcales	28221|Deltaproteobacteria	Q	Esterase PHB depolymerase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase_phd
SX3_k127_1983871_6	1540221.JQNI01000002_gene2151	0.0002532	55.0	COG3828@1|root,COG3828@2|Bacteria	2|Bacteria	N	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid_C,Big_3_2,Big_3_5,Metallophos,ThuA,VCBS
SX3_k127_1983871_1	351160.RCIX702	1.349e-48	182.0	COG0468@1|root,arCOG00417@2157|Archaea,2XTI2@28890|Euryarchaeota,2N9KC@224756|Methanomicrobia	224756|Methanomicrobia	L	Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange	radB	-	-	ko:K04484	-	-	-	-	ko00000,ko03400	-	-	-	Rad51
SX3_k127_1983871_4	498211.CJA_2763	2.144e-07	65.0	COG2273@1|root,COG3291@1|root,COG2273@2|Bacteria,COG3291@2|Bacteria,1N5RS@1224|Proteobacteria,1RSMD@1236|Gammaproteobacteria,1FHVH@10|Cellvibrio	1236|Gammaproteobacteria	G	Glycosyl hydrolase catalytic core	lamA	-	-	-	-	-	-	-	-	-	-	-	CBM_6,F5_F8_type_C,Glyco_hydro_16,Glyco_hydro_cc,PKD
SX3_k127_1983871_3	316067.Geob_0814	2.055e-12	82.0	COG1361@1|root,COG1520@1|root,COG1657@1|root,COG4257@1|root,COG4733@1|root,COG1361@2|Bacteria,COG1520@2|Bacteria,COG1657@2|Bacteria,COG4257@2|Bacteria,COG4733@2|Bacteria,1QYWJ@1224|Proteobacteria,43CDC@68525|delta/epsilon subdivisions,2X7P6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
SX3_k127_1983871_7	388467.A19Y_2237	0.0004741	54.0	COG3506@1|root,COG3506@2|Bacteria,1G5CJ@1117|Cyanobacteria,1HAX3@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF1349)	-	-	-	ko:K09702	-	-	-	-	ko00000	-	-	-	DUF1349
SX3_k127_1983871_0	673860.AciM339_1458	4.452e-112	379.0	COG1078@1|root,arCOG04430@2157|Archaea,2XUT7@28890|Euryarchaeota,3F2H2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
SX3_k127_1983871_5	323259.Mhun_2406	5.876e-05	55.0	COG0457@1|root,arCOG03038@2157|Archaea,2XUNW@28890|Euryarchaeota	28890|Euryarchaeota	O	TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
SX3_k127_1991316_0	330779.Saci_0929	1.563e-111	404.0	COG0464@1|root,arCOG01308@2157|Archaea,2XRPM@28889|Crenarchaeota	28889|Crenarchaeota	O	ATPase family	-	-	-	-	-	-	-	-	-	-	-	-	AAA,Vps4_C
SX3_k127_1991316_2	632335.Calkr_1360	4.338e-20	105.0	COG2304@1|root,COG2304@2|Bacteria,1V5MY@1239|Firmicutes,25BP9@186801|Clostridia	186801|Clostridia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA
SX3_k127_1991316_1	1121378.KB899696_gene2627	5.123e-47	197.0	COG2911@1|root,COG3291@1|root,COG2911@2|Bacteria,COG3291@2|Bacteria,1WKU1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	Pkd domain containing protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	PPC
SX3_k127_2031818_0	1500259.JQLD01000002_gene3008	1.312e-11	78.0	COG2202@1|root,COG2982@1|root,COG3209@1|root,COG3210@1|root,COG5295@1|root,COG2202@2|Bacteria,COG2982@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,COG5295@2|Bacteria,1QUXB@1224|Proteobacteria,2TWTY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,DUF4347
SX3_k127_2031818_1	1117314.PCIT_09614	8.729e-05	50.0	COG3325@1|root,COG3979@1|root,COG3325@2|Bacteria,COG3979@2|Bacteria,1MWAR@1224|Proteobacteria,1RPNS@1236|Gammaproteobacteria,2PZUK@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	G	COG3325 Chitinase	chiA	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	CBM_5_12,ChitinaseA_N,Glyco_hydro_18,REJ
SX3_k127_2041816_2	138119.DSY4291	9.907e-23	104.0	COG0517@1|root,COG0517@2|Bacteria,1VA1X@1239|Firmicutes,24MNT@186801|Clostridia,261ZT@186807|Peptococcaceae	186801|Clostridia	S	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SX3_k127_2041816_1	665571.STHERM_c06320	1.954e-49	181.0	COG0693@1|root,COG0693@2|Bacteria,2JB8Z@203691|Spirochaetes	203691|Spirochaetes	S	DJ-1/PfpI family	-	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
SX3_k127_2041816_5	65497.JODV01000010_gene2631	0.0004729	53.0	COG1473@1|root,COG1473@2|Bacteria,2GK05@201174|Actinobacteria,4E039@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM Peptidase family M20 M25 M40	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
SX3_k127_2041816_3	329726.AM1_2999	1.264e-05	59.0	COG2885@1|root,COG2885@2|Bacteria,1G2YF@1117|Cyanobacteria	1117|Cyanobacteria	M	COGs COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)protein	-	-	-	ko:K02557,ko:K03286	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1,1.B.6	-	-	OmpA
SX3_k127_2041816_4	926554.KI912668_gene5151	9.322e-05	55.0	COG1470@1|root,COG1470@2|Bacteria,1WNJB@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2041816_0	572546.Arcpr_0357	7.851e-129	422.0	COG1899@1|root,arCOG04142@2157|Archaea,2XSTD@28890|Euryarchaeota,2461M@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue	dys	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
SX3_k127_2051405_8	572546.Arcpr_1319	5.376e-13	81.0	COG0517@1|root,arCOG00600@2157|Archaea,2XU4J@28890|Euryarchaeota,245SK@183980|Archaeoglobi	183980|Archaeoglobi	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SX3_k127_2051405_5	589924.Ferp_0652	4.937e-71	252.0	COG0123@1|root,arCOG00324@2157|Archaea,2XT0B@28890|Euryarchaeota,246V5@183980|Archaeoglobi	183980|Archaeoglobi	BQ	PFAM histone deacetylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
SX3_k127_2051405_4	944480.ATUV01000001_gene603	1.666e-82	284.0	COG2057@1|root,COG2057@2|Bacteria,1MY3S@1224|Proteobacteria,42R4B@68525|delta/epsilon subdivisions,2WMZN@28221|Deltaproteobacteria,2M734@213113|Desulfurellales	28221|Deltaproteobacteria	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
SX3_k127_2051405_2	224325.AF_1199	3.099e-93	319.0	COG1788@1|root,arCOG01987@2157|Archaea,2XVRA@28890|Euryarchaeota,246WP@183980|Archaeoglobi	183980|Archaeoglobi	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
SX3_k127_2051405_0	439481.Aboo_0158	1.503e-116	386.0	COG0448@1|root,arCOG00912@2157|Archaea,2XTI4@28890|Euryarchaeota,3F2GM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	aspartate ornithine carbamoyltransferase carbamoyl-P binding domain	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
SX3_k127_2051405_1	671143.DAMO_1946	3.711e-112	404.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PKD,SBBP
SX3_k127_2051405_10	509191.AEDB02000065_gene677	3.583e-10	74.0	COG1705@1|root,COG2982@1|root,COG3291@1|root,COG4733@1|root,COG1705@2|Bacteria,COG2982@2|Bacteria,COG3291@2|Bacteria,COG4733@2|Bacteria,1UKT9@1239|Firmicutes,25G34@186801|Clostridia,3WP43@541000|Ruminococcaceae	2|Bacteria	NU	PKD domain	wcoB	-	3.2.1.1,3.2.1.4	ko:K01176,ko:K01179,ko:K02395,ko:K21429	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R06200,R11262,R11307,R11308	-	ko00000,ko00001,ko01000,ko01002,ko02035	-	GH13,GH5,GH9	-	Beta_helix,Malectin,PKD
SX3_k127_2051405_3	673860.AciM339_0524	1.528e-87	296.0	COG0463@1|root,arCOG01385@2157|Archaea,2XUEP@28890|Euryarchaeota,3F30S@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	PFAM Glycosyl transferase family 2	aglI	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SX3_k127_2051405_9	273116.14324495	3.237e-11	66.0	arCOG05238@1|root,arCOG05238@2157|Archaea,2Y0YG@28890|Euryarchaeota,242C6@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2051405_7	1232410.KI421426_gene1328	4.965e-36	156.0	COG0535@1|root,COG0535@2|Bacteria,1RADC@1224|Proteobacteria,43DPS@68525|delta/epsilon subdivisions,2X6SW@28221|Deltaproteobacteria,43TGW@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
SX3_k127_2051405_6	324057.Pjdr2_4647	1.938e-46	193.0	COG1595@1|root,COG1595@2|Bacteria,1VRNX@1239|Firmicutes,4HVBW@91061|Bacilli,26TMQ@186822|Paenibacillaceae	91061|Bacilli	K	GxGYxYP putative glycoside hydrolase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	GxGYxYP_C,GxGYxYP_N
SX3_k127_2051713_0	215803.DB30_3555	5.009e-14	87.0	COG2885@1|root,COG2931@1|root,COG2885@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,42T9J@68525|delta/epsilon subdivisions,2WU7T@28221|Deltaproteobacteria,2YWI9@29|Myxococcales	28221|Deltaproteobacteria	MQ	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2
SX3_k127_2086093_6	926550.CLDAP_33710	1.884e-20	98.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
SX3_k127_2086093_4	1051632.TPY_3673	2.523e-33	138.0	COG0110@1|root,COG1045@1|root,COG0110@2|Bacteria,COG1045@2|Bacteria,1TT21@1239|Firmicutes,24CCH@186801|Clostridia	186801|Clostridia	M	Bacterial transferase hexapeptide	wbpD	-	2.3.1.201	ko:K13018	ko00520,map00520	-	R10100	RC00004,RC00166	ko00000,ko00001,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2
SX3_k127_2086093_7	378806.STAUR_6097	3.369e-11	75.0	COG2159@1|root,COG2159@2|Bacteria,1PWNG@1224|Proteobacteria,42WWR@68525|delta/epsilon subdivisions,2X2CG@28221|Deltaproteobacteria,2YXI9@29|Myxococcales	28221|Deltaproteobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
SX3_k127_2086093_2	1345695.CLSA_c41670	1.63e-63	232.0	COG1052@1|root,COG1052@2|Bacteria,1VV1J@1239|Firmicutes,249XK@186801|Clostridia,36HAW@31979|Clostridiaceae	186801|Clostridia	CH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2086093_1	1408423.JHYA01000004_gene2380	5.937e-78	289.0	COG1088@1|root,COG1088@2|Bacteria,1TPWM@1239|Firmicutes	1239|Firmicutes	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	-	-	4.2.1.46,5.1.3.2	ko:K01710,ko:K01784	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R02984,R06513	RC00289,RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
SX3_k127_2086093_0	693746.OBV_05420	2.585e-83	289.0	COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,24862@186801|Clostridia,2N8JP@216572|Oscillospiraceae	186801|Clostridia	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
SX3_k127_2086093_5	272559.BF9343_3219	6.653e-25	124.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	nanA	GO:0001573,GO:0003674,GO:0003824,GO:0004308,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006672,GO:0006687,GO:0006689,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0016020,GO:0016042,GO:0016052,GO:0016787,GO:0016798,GO:0016997,GO:0019377,GO:0030149,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044424,GO:0044464,GO:0046466,GO:0046479,GO:0046514,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1903509	3.2.1.18	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	-	R04018	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33	-	BNR_2,Gram_pos_anchor,Sialidase,YSIRK_signal
SX3_k127_2086093_3	243231.GSU2073	1.692e-52	215.0	COG3209@1|root,COG3227@1|root,COG3391@1|root,COG3209@2|Bacteria,COG3227@2|Bacteria,COG3391@2|Bacteria,1QW4H@1224|Proteobacteria	1224|Proteobacteria	M	Rhs Family	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Autotransporter,Big_3_2,Big_3_5,DUF4082,DUF4347,He_PIG,PT-HINT,RHS_repeat
SX3_k127_2121134_0	340099.Teth39_0216	4.533e-176	578.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,42EUY@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
SX3_k127_2121134_2	880073.Calab_2035	2.093e-84	291.0	COG0543@1|root,COG0543@2|Bacteria,2NNUA@2323|unclassified Bacteria	2|Bacteria	CH	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	gltA	-	1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14	ko:K00266,ko:K00528,ko:K02823	ko00240,ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00240,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248,R10159	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,Fer4_20,NAD_binding_1,Pyr_redox_2
SX3_k127_2121134_4	1379698.RBG1_1C00001G1377	1.072e-45	184.0	COG4409@1|root,COG4409@2|Bacteria,2NRD7@2323|unclassified Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	ASH,BNR_2,Big_3_2,CBM_35,DUF1080,F5_F8_type_C,PKD,RicinB_lectin_2,Trehalase
SX3_k127_2121134_3	378753.KRH_04810	2.221e-47	184.0	COG0123@1|root,COG0123@2|Bacteria,2GJUH@201174|Actinobacteria,1W7JP@1268|Micrococcaceae	201174|Actinobacteria	BQ	acetoin utilization protein	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
SX3_k127_2121134_1	1047013.AQSP01000073_gene1101	1.403e-170	544.0	COG0281@1|root,COG0281@2|Bacteria,2NNV3@2323|unclassified Bacteria	2|Bacteria	C	Malic enzyme, NAD binding domain	mez_1	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,malic
SX3_k127_2138747_0	1041930.Mtc_0188	4.829e-118	387.0	COG1209@1|root,arCOG00667@2157|Archaea,2Y87B@28890|Euryarchaeota	28890|Euryarchaeota	M	Glucose-1-phosphate thymidyltransferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
SX3_k127_2138747_1	273116.14324441	1.956e-32	144.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y8EG@28890|Euryarchaeota,2424M@183967|Thermoplasmata	183967|Thermoplasmata	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX3_k127_2138747_3	28532.XP_010550866.1	2.069e-06	58.0	COG5078@1|root,KOG0417@2759|Eukaryota,37QGG@33090|Viridiplantae,3G8M8@35493|Streptophyta,3HSHB@3699|Brassicales	35493|Streptophyta	O	ubiquitin-conjugating enzyme	-	GO:0000209,GO:0003674,GO:0003824,GO:0004842,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016567,GO:0016740,GO:0019538,GO:0019787,GO:0019899,GO:0031625,GO:0032446,GO:0033554,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044389,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0061630,GO:0061659,GO:0070647,GO:0071704,GO:0140096,GO:1901564	2.3.2.23	ko:K13960	ko03460,map03460	-	-	-	ko00000,ko00001,ko01000,ko03400,ko04121	-	-	-	UQ_con
SX3_k127_2138747_2	1236689.MMALV_16250	2.595e-31	133.0	COG0560@1|root,arCOG01158@2157|Archaea	2157|Archaea	E	phosphoserine phosphatase	serB	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD,Hydrolase,Hydrolase_3
SX3_k127_2142401_7	285514.JNWO01000001_gene4656	8.215e-05	56.0	2B4XN@1|root,31XQJ@2|Bacteria,2GZEZ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2142401_0	706587.Desti_1830	2.396e-141	457.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42Y7P@68525|delta/epsilon subdivisions,2WUJA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SX3_k127_2142401_1	1449126.JQKL01000002_gene1587	1.227e-117	395.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia	186801|Clostridia	C	electron transfer flavoprotein	-	-	1.3.1.108	ko:K03522,ko:K22432	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	ETF,ETF_alpha,Fer4
SX3_k127_2142401_4	706587.Desti_1828	1.652e-82	282.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,42RCI@68525|delta/epsilon subdivisions,2WM55@28221|Deltaproteobacteria,2MQDQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Electron transfer flavoprotein	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
SX3_k127_2142401_8	400682.PAC_15712780	0.0005913	44.0	KOG2669@1|root,KOG2669@2759|Eukaryota,38XYH@33154|Opisthokonta,3BH80@33208|Metazoa	33208|Metazoa	A	mRNA 3'-end processing	RPRD2	GO:0000228,GO:0000428,GO:0000785,GO:0000790,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0006139,GO:0006351,GO:0006366,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009301,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016073,GO:0016591,GO:0018130,GO:0019438,GO:0030880,GO:0031123,GO:0031124,GO:0031974,GO:0031981,GO:0032774,GO:0032991,GO:0034641,GO:0034645,GO:0034654,GO:0034660,GO:0042795,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044451,GO:0044454,GO:0044464,GO:0046483,GO:0055029,GO:0061695,GO:0070013,GO:0071704,GO:0090304,GO:0097659,GO:0098781,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	-	-	-	-	-	-	-	-	-	-	CREPT,CTD_bind
SX3_k127_2142401_2	647113.Metok_0186	1.879e-114	389.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23QA9@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
SX3_k127_2142401_5	1121428.DESHY_40206___1	5.851e-53	200.0	COG1148@1|root,COG1148@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia,260ZH@186807|Peptococcaceae	186801|Clostridia	C	binding domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_9,NAD_binding_8,Pyr_redox_2
SX3_k127_2142401_3	706587.Desti_0010	3.56e-94	336.0	COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1QUMN@1224|Proteobacteria,43BMA@68525|delta/epsilon subdivisions,2X6ZG@28221|Deltaproteobacteria,2MR5E@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NAD(P)-binding Rossmann-like domain	hdrA	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,FlpD,Pyr_redox_2
SX3_k127_2142401_6	1121440.AUMA01000003_gene3124	1.035e-10	67.0	COG0247@1|root,COG0247@2|Bacteria,1N5Q2@1224|Proteobacteria,42P5D@68525|delta/epsilon subdivisions,2WJ9I@28221|Deltaproteobacteria,2M8U9@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_10,Fer4_17,Fer4_8
SX3_k127_2147654_1	195253.Syn6312_0849	7.199e-67	236.0	COG2189@1|root,COG2189@2|Bacteria,1GD68@1117|Cyanobacteria,1H3EE@1129|Synechococcus	2|Bacteria	L	PFAM DNA methylase	-	-	2.1.1.113,2.1.1.72	ko:K00571,ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
SX3_k127_2147654_0	1321778.HMPREF1982_02115	1.679e-156	509.0	COG0531@1|root,COG0531@2|Bacteria,1TQ4K@1239|Firmicutes,25E7A@186801|Clostridia,269PQ@186813|unclassified Clostridiales	186801|Clostridia	E	Psort location CytoplasmicMembrane, score 10.00	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
SX3_k127_2147654_2	292415.Tbd_0674	6.983e-13	81.0	COG0477@1|root,COG2814@2|Bacteria,1RB5E@1224|Proteobacteria,2VQNK@28216|Betaproteobacteria,1KSII@119069|Hydrogenophilales	119069|Hydrogenophilales	EGP	Uncharacterised MFS-type transporter YbfB	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
SX3_k127_2259877_25	1042877.GQS_06740	3.158e-06	55.0	COG1572@1|root,arCOG07086@2157|Archaea,2Y2HS@28890|Euryarchaeota,2436N@183968|Thermococci	183968|Thermococci	G	CARDB	-	-	-	-	-	-	-	-	-	-	-	-	CARDB
SX3_k127_2259877_2	439481.Aboo_1446	7.293e-82	299.0	COG0750@1|root,arCOG00609@2157|Archaea,2XT29@28890|Euryarchaeota,3F2WK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
SX3_k127_2259877_5	272134.KB731324_gene5834	2.883e-62	228.0	COG0438@1|root,COG0438@2|Bacteria,1G13Y@1117|Cyanobacteria,1H80H@1150|Oscillatoriales	1117|Cyanobacteria	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glycos_transf_1
SX3_k127_2259877_28	744980.TRICHSKD4_2504	0.0004	53.0	COG2244@1|root,COG2244@2|Bacteria,1MWKV@1224|Proteobacteria,2TTYS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Membrane protein involved in the export of O-antigen and teichoic acid	MA20_18165	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
SX3_k127_2259877_14	646529.Desaci_0373	1.043e-17	85.0	COG0425@1|root,COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0425@2|Bacteria,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,2606T@186807|Peptococcaceae	186801|Clostridia	P	pyridine nucleotide-disulphide oxidoreductase dimerisation	cdr	-	-	-	-	-	-	-	-	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
SX3_k127_2259877_12	187272.Mlg_1655	9.512e-25	111.0	COG1553@1|root,COG1553@2|Bacteria,1N021@1224|Proteobacteria,1S99J@1236|Gammaproteobacteria,1WY2D@135613|Chromatiales	135613|Chromatiales	P	TIGRFAM sulfur relay protein TusD DsrE	dsrE	GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0019417,GO:0044237,GO:0055114	-	ko:K07235	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE
SX3_k127_2259877_24	477228.YO5_01629	2.415e-07	58.0	COG2923@1|root,COG2923@2|Bacteria,1N8RV@1224|Proteobacteria,1SD0S@1236|Gammaproteobacteria,1Z324@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	P	Belongs to the DsrF TusC family	tusC	GO:0002097,GO:0002098,GO:0002143,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1902494,GO:1990228,GO:1990234	-	ko:K07236	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DrsE
SX3_k127_2259877_21	194439.CT0857	1.337e-08	64.0	COG2168@1|root,COG2168@2|Bacteria,1FFCU@1090|Chlorobi	1090|Chlorobi	P	PFAM DsrH family protein	-	-	-	ko:K07237	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DsrH
SX3_k127_2259877_4	304371.MCP_0141	3.598e-71	256.0	COG1801@1|root,arCOG04291@2157|Archaea,2XY6C@28890|Euryarchaeota,2NA4H@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
SX3_k127_2259877_23	797302.Halru_0692	1.649e-07	59.0	arCOG07300@1|root,arCOG07300@2157|Archaea,2XZDR@28890|Euryarchaeota,23XD6@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2259877_3	1297570.MESS4_360031	1.141e-80	293.0	COG0697@1|root,COG0697@2|Bacteria,1N3FA@1224|Proteobacteria,2TTFI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp,EamA
SX3_k127_2259877_15	529709.PYCH_01930	3.837e-17	90.0	arCOG00743@1|root,arCOG00743@2157|Archaea,2Y3FU@28890|Euryarchaeota,2445D@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2259877_20	673860.AciM339_0945	2.387e-09	62.0	arCOG04079@1|root,arCOG04079@2157|Archaea,2Y184@28890|Euryarchaeota,3F3HW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2259877_6	1157490.EL26_19780	2.122e-60	223.0	COG0803@1|root,COG0803@2|Bacteria,1TPG7@1239|Firmicutes,4H9UN@91061|Bacilli,278FS@186823|Alicyclobacillaceae	91061|Bacilli	P	Belongs to the bacterial solute-binding protein 9 family	-	-	-	ko:K09818	-	M00243	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ZnuA
SX3_k127_2259877_8	1444309.JAQG01000088_gene4183	7.495e-56	210.0	COG1121@1|root,COG1121@2|Bacteria,1TQ68@1239|Firmicutes,4HAZI@91061|Bacilli,26RXW@186822|Paenibacillaceae	91061|Bacilli	P	ABC transporter	zurA	-	-	ko:K02074,ko:K09817	ko02010,map02010	M00242,M00244	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
SX3_k127_2259877_9	1459636.NTE_00034	1.743e-53	200.0	COG1108@1|root,arCOG01006@2157|Archaea,41SG2@651137|Thaumarchaeota	651137|Thaumarchaeota	P	ABC 3 transport family	-	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
SX3_k127_2259877_19	941449.dsx2_1614	6.076e-10	71.0	COG0864@1|root,COG0864@2|Bacteria,1RK4R@1224|Proteobacteria,42SID@68525|delta/epsilon subdivisions,2WQ86@28221|Deltaproteobacteria,2MBEU@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	Transcriptional regulator	nikR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
SX3_k127_2259877_1	697303.Thewi_0615	5.79e-94	315.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,42EVN@68295|Thermoanaerobacterales	186801|Clostridia	I	Belongs to the enoyl-CoA hydratase isomerase family	crt	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
SX3_k127_2259877_16	1232430.CAVG010000025_gene220	2.041e-13	78.0	COG3402@1|root,COG3402@2|Bacteria,1VFTS@1239|Firmicutes,4HPTD@91061|Bacilli,4GZGI@90964|Staphylococcaceae	91061|Bacilli	S	Bacterial PH domain	ydbS	-	-	ko:K09167	-	-	-	-	ko00000	-	-	-	bPH_2
SX3_k127_2259877_7	449447.MAE_26720	2.925e-57	229.0	COG0457@1|root,COG0457@2|Bacteria,1G135@1117|Cyanobacteria	1117|Cyanobacteria	U	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	NB-ARC,TPR_12,TPR_7
SX3_k127_2259877_11	2074.JNYD01000001_gene5846	1.642e-25	125.0	COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,2H57H@201174|Actinobacteria,4EF5W@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,Trans_reg_C
SX3_k127_2259877_0	706587.Desti_4689	1.913e-113	372.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42M6J@68525|delta/epsilon subdivisions,2WJZQ@28221|Deltaproteobacteria,2MQSA@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	mmgB	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
SX3_k127_2259877_27	593117.TGAM_0097	2.305e-05	58.0	arCOG03799@1|root,arCOG03799@2157|Archaea,2Y2EX@28890|Euryarchaeota,245N4@183968|Thermococci	183968|Thermococci	T	Protein of unknown function (DUF835)	-	-	-	-	-	-	-	-	-	-	-	-	DUF835
SX3_k127_2259877_10	56107.Cylst_4248	3.537e-44	177.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria,1HIQE@1161|Nostocales	1117|Cyanobacteria	K	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
SX3_k127_2259877_18	211165.AJLN01000083_gene1480	3.905e-12	72.0	COG1598@1|root,COG1598@2|Bacteria,1G9CM@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
SX3_k127_2259877_13	797303.Natpe_3891	5.031e-19	96.0	arCOG12277@1|root,arCOG12277@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
SX3_k127_2259877_17	1238425.J07HQW2_02209	2.316e-12	75.0	arCOG06565@1|root,arCOG06565@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2259877_22	348780.NP_1128A	6.948e-08	64.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWHT@28890|Euryarchaeota,23V64@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	gntR	-	-	-	-	-	-	-	-	-	-	-	HTH_24,HTH_5,MarR_2
SX3_k127_2289773_0	314271.RB2654_10713	3.455e-65	244.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase,Cadherin,FG-GAP,Glyco_hydro_26,HemolysinCabind,Integrin_beta,Lipase_GDSL_2
SX3_k127_2357628_0	697303.Thewi_0169	1.71e-105	365.0	COG0574@1|root,COG0574@2|Bacteria,1TW0W@1239|Firmicutes,248VM@186801|Clostridia,42FZJ@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM pyruvate phosphate dikinase, PEP pyruvate-binding	-	-	-	-	-	-	-	-	-	-	-	-	PPDK_N
SX3_k127_2357628_1	869210.Marky_1204	2.233e-33	138.0	COG0491@1|root,COG0491@2|Bacteria,1WISH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SX3_k127_2357628_2	204669.Acid345_3876	1.64e-26	113.0	COG5580@1|root,COG5580@2|Bacteria,3Y90D@57723|Acidobacteria,2JNT0@204432|Acidobacteriia	204432|Acidobacteriia	O	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
SX3_k127_2380364_2	351160.RCIX2365	2.318e-50	183.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,2N99U@224756|Methanomicrobia	224756|Methanomicrobia	S	KH, type 1, domain	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_2,KH_7,Lactamase_B,Lactamase_B_6,RMMBL
SX3_k127_2380364_1	439481.Aboo_0123	5.567e-69	241.0	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,3F2PC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019774,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070003,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
SX3_k127_2380364_0	523845.AQXV01000026_gene1469	7.39e-93	345.0	arCOG02545@1|root,arCOG02545@2157|Archaea	2157|Archaea	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NosD,PKD
SX3_k127_2380364_3	1227739.Hsw_PA0222	9.043e-21	104.0	COG0382@1|root,COG2175@1|root,COG0382@2|Bacteria,COG2175@2|Bacteria,4P3R6@976|Bacteroidetes	976|Bacteroidetes	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
SX3_k127_2380364_4	1227739.Hsw_PA0222	2.41e-18	96.0	COG0382@1|root,COG2175@1|root,COG0382@2|Bacteria,COG2175@2|Bacteria,4P3R6@976|Bacteroidetes	976|Bacteroidetes	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
SX3_k127_2385249_4	105559.Nwat_2385	2.771e-26	127.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1SIJC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
SX3_k127_2385249_6	1191523.MROS_2005	1.003e-24	122.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2385249_3	693661.Arcve_1381	6.228e-28	114.0	arCOG14051@1|root,arCOG14051@2157|Archaea,2Y4SW@28890|Euryarchaeota	28890|Euryarchaeota	S	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
SX3_k127_2385249_7	693661.Arcve_1382	1.014e-23	103.0	COG1598@1|root,arCOG02411@2157|Archaea,2Y4XF@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
SX3_k127_2385249_8	931277.C448_05963	4.337e-09	66.0	COG3413@1|root,arCOG02276@2157|Archaea,2XVCM@28890|Euryarchaeota,23V0F@183963|Halobacteria	183963|Halobacteria	K	DNA binding protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_10
SX3_k127_2385249_5	1054217.TALC_00756	9.409e-26	118.0	28M2T@1|root,2N55N@2157|Archaea,2Y31V@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2385249_2	1220534.B655_0497	1.54e-34	152.0	COG0574@1|root,arCOG01114@2157|Archaea	2157|Archaea	G	Pyruvate phosphate dikinase	-	-	2.7.3.13,2.7.9.2	ko:K01007,ko:K22424	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
SX3_k127_2385249_1	304371.MCP_1482	9.965e-35	140.0	COG0574@1|root,arCOG01114@2157|Archaea,2XVSY@28890|Euryarchaeota	28890|Euryarchaeota	G	pyruvate phosphate dikinase	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
SX3_k127_2385249_9	635013.TherJR_2864	3.493e-05	50.0	COG4733@1|root,COG4932@1|root,COG4733@2|Bacteria,COG4932@2|Bacteria,1UTKZ@1239|Firmicutes,253GX@186801|Clostridia	186801|Clostridia	C	SMART Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1,Pur_ac_phosph_N
SX3_k127_2385249_0	880072.Desac_0390	5.685e-38	158.0	COG4122@1|root,COG4122@2|Bacteria,1R4VI@1224|Proteobacteria,42VVN@68525|delta/epsilon subdivisions,2WRTH@28221|Deltaproteobacteria,2MS9X@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	O-methyltransferase	-	-	2.1.1.104	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	M00039,M00350	R01942,R06578	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_3
SX3_k127_2424275_3	1123278.KB893387_gene4430	4.092e-15	91.0	COG1577@1|root,COG1874@1|root,COG3391@1|root,COG1577@2|Bacteria,COG1874@2|Bacteria,COG3391@2|Bacteria,4PPRK@976|Bacteroidetes,47TYG@768503|Cytophagia	976|Bacteroidetes	G	Dystroglycan-type cadherin-like domains.	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2424275_0	1173020.Cha6605_4440	4.037e-206	707.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria	1117|Cyanobacteria	O	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
SX3_k127_2424275_2	439481.Aboo_0002	1.04e-37	158.0	COG0681@1|root,arCOG01739@2157|Archaea,2Y6XH@28890|Euryarchaeota,3F2QN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	U	Signal peptidase	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	-
SX3_k127_2424275_1	439481.Aboo_0001	6.496e-140	458.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,3F2IJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Involved in regulation of DNA replication	cdc6	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA,AAA_16,AAA_22,Cdc6_C
SX3_k127_2437790_1	439481.Aboo_1245	1.594e-47	178.0	COG1467@1|root,arCOG04110@2157|Archaea,2XUZF@28890|Euryarchaeota,3F2IZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901363,GO:1901576	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
SX3_k127_2437790_3	744872.Spica_1998	1.81e-21	111.0	COG3210@1|root,COG3210@2|Bacteria,2JBDG@203691|Spirochaetes	203691|Spirochaetes	U	domain, Protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	-
SX3_k127_2437790_4	246969.TAM4_1862	4.604e-14	77.0	COG1487@1|root,arCOG02219@2157|Archaea	2157|Archaea	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
SX3_k127_2437790_0	243232.MJ_1364	3.914e-49	194.0	COG0585@1|root,arCOG04252@2157|Archaea,2XVPH@28890|Euryarchaeota,23Q00@183939|Methanococci	183939|Methanococci	J	tRNA pseudouridine synthase D	-	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
SX3_k127_2437790_2	1054217.TALC_00321	8.25e-41	158.0	COG0618@1|root,arCOG01565@2157|Archaea,2XWQV@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM phosphoesterase, RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
SX3_k127_2459565_2	439481.Aboo_1089	1.304e-119	397.0	COG0086@1|root,arCOG04256@2157|Archaea,2XTJ6@28890|Euryarchaeota,3F2IB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03042	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Intein_splicing,LAGLIDADG_3,RNA_pol_Rpb1_5
SX3_k127_2459565_0	439481.Aboo_1090	0.0	1206.0	COG0086@1|root,arCOG04257@2157|Archaea,2XTBZ@28890|Euryarchaeota,3F2IK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA1	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
SX3_k127_2459565_1	351160.LRC356	2.591e-256	805.0	COG0085@1|root,arCOG01762@2157|Archaea,2XU1X@28890|Euryarchaeota,2N93R@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB2	-	2.7.7.6	ko:K03044	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
SX3_k127_2489996_1	439481.Aboo_0565	5.007e-19	91.0	COG2004@1|root,arCOG04182@2157|Archaea,2Y6EY@28890|Euryarchaeota,3F2VW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eS24 family	rps24e	-	-	ko:K02974	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S24e
SX3_k127_2489996_0	604354.TSIB_0028	8.645e-26	113.0	COG1909@1|root,arCOG04076@2157|Archaea,2XXSG@28890|Euryarchaeota,2440N@183968|Thermococci	183968|Thermococci	S	Belongs to the UPF0218 family	-	-	-	ko:K09735	-	-	-	-	ko00000	-	-	-	DUF359
SX3_k127_2540540_2	523845.AQXV01000026_gene1469	1.458e-70	270.0	arCOG02545@1|root,arCOG02545@2157|Archaea	2157|Archaea	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NosD,PKD
SX3_k127_2540540_1	1236689.MMALV_03210	8.765e-89	309.0	COG0621@1|root,arCOG01358@2157|Archaea,2XSVB@28890|Euryarchaeota,3F2IY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Uncharacterized protein family UPF0004	miaB	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035598,GO:0035600,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050497,GO:0071704,GO:0090304,GO:1901360	2.8.4.5	ko:K15865	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
SX3_k127_2540540_5	573370.DMR_37250	6.531e-13	81.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,42NA4@68525|delta/epsilon subdivisions,2WKTU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX3_k127_2540540_0	1236689.MMALV_16140	2.43e-121	410.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTAH@28890|Euryarchaeota,3F2JT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	TIGRFAM hydrogenase expression formation protein HypE	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
SX3_k127_2540540_4	195250.CM001776_gene965	7.093e-16	94.0	COG2931@1|root,COG3209@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat,VCBS
SX3_k127_2540540_3	398578.Daci_4515	8.307e-25	123.0	COG0823@1|root,COG0841@1|root,COG1361@1|root,COG1572@1|root,COG1657@1|root,COG4733@1|root,COG0823@2|Bacteria,COG0841@2|Bacteria,COG1361@2|Bacteria,COG1572@2|Bacteria,COG1657@2|Bacteria,COG4733@2|Bacteria,1QVSF@1224|Proteobacteria	1224|Proteobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,DUF11,DUF1566,Laminin_G_3,OmpA,OmpA_membrane,TIG
SX3_k127_2541126_0	1220534.B655_1686	5.827e-39	151.0	COG0500@1|root,arCOG02702@2157|Archaea,2XWS9@28890|Euryarchaeota	28890|Euryarchaeota	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
SX3_k127_2541126_1	1123508.JH636439_gene346	0.0002965	53.0	COG2706@1|root,COG3210@1|root,COG3391@1|root,COG4932@1|root,COG2706@2|Bacteria,COG3210@2|Bacteria,COG3391@2|Bacteria,COG4932@2|Bacteria,2IY8U@203682|Planctomycetes	203682|Planctomycetes	M	Integrin alpha (beta-propellor repeats).	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
SX3_k127_2541994_2	552811.Dehly_0222	9.266e-59	216.0	COG0169@1|root,COG0169@2|Bacteria,2G6FG@200795|Chloroflexi,34CWQ@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_dh_N
SX3_k127_2541994_0	410358.Mlab_1654	2.67e-90	304.0	COG1830@1|root,arCOG04044@2157|Archaea,2XTBQ@28890|Euryarchaeota,2N9E2@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids	aroF	-	2.2.1.10,4.1.2.13	ko:K16306	ko00010,ko00030,ko00051,ko00400,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00400,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001	R01068,R01070,R02568,R08568	RC00438,RC00439,RC00721,RC02301	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0920	DeoC
SX3_k127_2541994_1	192952.MM_1272	3.613e-79	276.0	COG1465@1|root,arCOG04353@2157|Archaea,2XSXD@28890|Euryarchaeota,2N9AV@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis	aroB'	-	1.4.1.24	ko:K11646	ko00400,ko01110,ko01130,map00400,map01110,map01130	-	R08569	RC02302	ko00000,ko00001,ko01000	-	-	-	DHQS
SX3_k127_2541994_3	410358.Mlab_1651	7.072e-50	189.0	COG1685@1|root,arCOG01025@2157|Archaea,2XUI2@28890|Euryarchaeota,2N96J@224756|Methanomicrobia	224756|Methanomicrobia	E	shikimate kinase activity	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A3127	GHMP_kinases_N
SX3_k127_2571279_14	1121918.ARWE01000001_gene50	2.715e-07	64.0	COG3291@1|root,COG3420@1|root,COG3291@2|Bacteria,COG3420@2|Bacteria,1Q5XI@1224|Proteobacteria,437EC@68525|delta/epsilon subdivisions,2X2KQ@28221|Deltaproteobacteria,43VY4@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2571279_10	1005994.GTGU_03271	6.629e-21	109.0	COG2911@1|root,COG2911@2|Bacteria,1P8N9@1224|Proteobacteria,1T1IH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	PFAM FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Big_3_3,VCBS
SX3_k127_2571279_9	1397278.AYMV01000014_gene1906	4.933e-21	110.0	COG2931@1|root,COG2931@2|Bacteria,2ICU9@201174|Actinobacteria,4FMQX@85023|Microbacteriaceae	201174|Actinobacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2571279_15	292459.STH43	1.391e-05	59.0	COG2373@1|root,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Cadherin,Calx-beta,He_PIG,IAT_beta,SLH
SX3_k127_2571279_6	439481.Aboo_0733	1.446e-38	155.0	COG0367@1|root,arCOG00071@2157|Archaea,2XSYP@28890|Euryarchaeota,3F3FU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_6,GATase_7
SX3_k127_2571279_4	1054217.TALC_01148	4.599e-120	400.0	COG0585@1|root,arCOG04252@2157|Archaea,2XUTK@28890|Euryarchaeota,241NZ@183967|Thermoplasmata	183967|Thermoplasmata	J	Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs	truD	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
SX3_k127_2571279_12	439481.Aboo_1383	2.416e-13	74.0	COG1761@1|root,arCOG04111@2157|Archaea,2XZVZ@28890|Euryarchaeota,3F2UR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoL	-	2.7.7.6	ko:K03056	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_L_2
SX3_k127_2571279_8	1121272.KB903250_gene2912	6.797e-30	137.0	COG2866@1|root,COG4935@1|root,COG2866@2|Bacteria,COG4935@2|Bacteria,2GN49@201174|Actinobacteria,4DAA1@85008|Micromonosporales	201174|Actinobacteria	M	Peptidase M14, carboxypeptidase A	-	-	3.4.17.18	ko:K05996	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	P_proprotein,Peptidase_M14
SX3_k127_2571279_2	289376.THEYE_A0518	3.259e-169	545.0	COG0863@1|root,COG1525@1|root,COG0863@2|Bacteria,COG1525@2|Bacteria	2|Bacteria	L	nuclease	-	-	2.1.1.113,3.1.31.1	ko:K00590,ko:K01174,ko:K02027	-	M00207	-	-	ko00000,ko00002,ko01000,ko02000,ko02048	3.A.1.1	-	-	Excalibur,N6_N4_Mtase,SNase
SX3_k127_2571279_5	1157490.EL26_04335	1.484e-98	348.0	COG1502@1|root,COG2356@1|root,COG1502@2|Bacteria,COG2356@2|Bacteria	2|Bacteria	L	deoxyribonuclease I activity	-	-	-	ko:K06131,ko:K06915	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	CARDB,F5_F8_type_C,Helicase_C,LTD,MAM,PLDc_2,Peptidase_S8,Reprolysin_4,ResIII,fn3
SX3_k127_2571279_11	868131.MSWAN_0021	1.052e-18	99.0	COG1967@1|root,arCOG02177@2157|Archaea,2XT8V@28890|Euryarchaeota,23PGC@183925|Methanobacteria	183925|Methanobacteria	S	Membrane protein of unknown function DUF63	-	-	-	-	-	-	-	-	-	-	-	-	DUF63
SX3_k127_2571279_3	439481.Aboo_0536	1.359e-122	402.0	COG0371@1|root,arCOG00982@2157|Archaea,2XT0F@28890|Euryarchaeota,3F2IT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea	egsA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
SX3_k127_2571279_7	573063.Metin_1058	5.483e-38	147.0	COG1860@1|root,arCOG04477@2157|Archaea,2XX8X@28890|Euryarchaeota,23QYT@183939|Methanococci	183939|Methanococci	S	Belongs to the UPF0179 family	-	-	-	ko:K09730	-	-	-	-	ko00000	-	-	-	UPF0179
SX3_k127_2571279_13	1340493.JNIF01000004_gene1097	1.638e-09	65.0	COG0457@1|root,COG0457@2|Bacteria,3Y6HC@57723|Acidobacteria	1340493.JNIF01000004_gene1097|-	C	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2571279_0	593750.Metfor_1649	0.0	1084.0	COG0457@1|root,arCOG03042@1|root,arCOG03032@2157|Archaea,arCOG03038@2157|Archaea,arCOG03042@2157|Archaea,2XUNW@28890|Euryarchaeota,2NAN4@224756|Methanomicrobia	224756|Methanomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
SX3_k127_2571279_1	203124.Tery_3996	1.98e-257	838.0	COG0457@1|root,COG4976@1|root,COG0457@2|Bacteria,COG4976@2|Bacteria,1G20P@1117|Cyanobacteria,1H8AZ@1150|Oscillatoriales	1117|Cyanobacteria	L	Tetratricopeptide repeat	-	-	-	ko:K12600	ko03018,map03018	M00392	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	TPR_1,TPR_2,TPR_8
SX3_k127_2571279_16	439481.Aboo_0134	3.979e-05	53.0	COG4870@1|root,arCOG02499@1|root,arCOG05978@1|root,arCOG02499@2157|Archaea,arCOG03607@2157|Archaea,arCOG05978@2157|Archaea	2157|Archaea	C	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_5,Kelch_1,NosD,Peptidase_C1,S_layer_C,fn3
SX3_k127_257623_0	192952.MM_1299	7.036e-10	69.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTJP@28890|Euryarchaeota,2N93V@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	tRNA_anti-codon
SX3_k127_257623_1	546414.Deide_06190	4.543e-09	69.0	COG1520@1|root,COG1520@2|Bacteria,1WMGH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PQQ enzyme repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_3
SX3_k127_2589802_0	273068.TTE2609	9.545e-198	634.0	COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,2482E@186801|Clostridia,42F21@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS01075	CTP_synth_N,GATase
SX3_k127_2589802_6	1041930.Mtc_2164	1.674e-56	215.0	COG2102@1|root,arCOG00035@2157|Archaea,2XTNJ@28890|Euryarchaeota,2N9QU@224756|Methanomicrobia	224756|Methanomicrobia	E	Diphthamide synthase	-	-	6.3.1.14	ko:K06927	-	-	R03613	RC00358	ko00000,ko01000,ko03012	-	-	-	Diphthami_syn_2
SX3_k127_2589802_14	667014.Thein_0564	3.962e-11	75.0	COG1254@1|root,COG1254@2|Bacteria,2GHZK@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Acylphosphatase	-	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
SX3_k127_2589802_9	332101.JIBU02000012_gene997	4.26e-40	157.0	COG0655@1|root,COG0655@2|Bacteria,1TRKM@1239|Firmicutes,24AD6@186801|Clostridia,36FJ2@31979|Clostridiaceae	186801|Clostridia	S	reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,Flavodoxin_2,SCP2
SX3_k127_2589802_10	868131.MSWAN_2137	5.8e-34	136.0	COG0720@1|root,arCOG02172@2157|Archaea,2XXFY@28890|Euryarchaeota,23PMK@183925|Methanobacteria	183925|Methanobacteria	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
SX3_k127_2589802_8	456442.Mboo_1172	4.439e-47	195.0	COG0457@1|root,arCOG03048@1|root,arCOG03032@2157|Archaea,arCOG03038@2157|Archaea,arCOG03048@2157|Archaea,2XUNW@28890|Euryarchaeota,2NAF9@224756|Methanomicrobia	224756|Methanomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
SX3_k127_2589802_3	439481.Aboo_0781	7.072e-93	314.0	COG1469@1|root,arCOG04301@2157|Archaea,2XT11@28890|Euryarchaeota,3F2JX@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin	mptA	GO:0003674,GO:0003824,GO:0003933,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044682	3.5.4.39	ko:K17488	ko00790,map00790	-	R10348	RC02504,RC03131	ko00000,ko00001,ko01000	-	-	-	GCHY-1
SX3_k127_2589802_2	696369.KI912183_gene2375	3.826e-100	340.0	COG0294@1|root,COG0294@2|Bacteria,1TPKT@1239|Firmicutes,248BE@186801|Clostridia,260AI@186807|Peptococcaceae	186801|Clostridia	H	dihydropteroate synthase	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS03115	Pterin_bind
SX3_k127_2589802_13	207559.Dde_2190	3.835e-23	107.0	COG0546@1|root,COG0546@2|Bacteria,1N2ZG@1224|Proteobacteria,42TKG@68525|delta/epsilon subdivisions,2WQ3W@28221|Deltaproteobacteria,2MBDT@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
SX3_k127_2589802_4	589924.Ferp_1665	4.426e-75	279.0	COG0069@1|root,COG1145@1|root,arCOG00619@2157|Archaea,arCOG02187@2157|Archaea,2Y7H6@28890|Euryarchaeota,245Q2@183980|Archaeoglobi	183980|Archaeoglobi	E	Belongs to the glutamate synthase family	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Glu_syn_central,Glu_synthase
SX3_k127_2589802_12	1265505.ATUG01000001_gene4759	3.757e-25	113.0	COG0069@1|root,COG2218@1|root,COG0069@2|Bacteria,COG2218@2|Bacteria,1MU7B@1224|Proteobacteria,42MF7@68525|delta/epsilon subdivisions,2WJJR@28221|Deltaproteobacteria,2MICM@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Conserved region in glutamate synthase	-	-	2.1.1.21	ko:K22083	ko00680,ko01120,map00680,map01120	-	R01586	RC00554	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_10,Fer4_7,Fer4_9,GXGXG,Glu_syn_central,Glu_synthase
SX3_k127_2589802_1	224325.AF_0920	1.958e-160	516.0	COG0017@1|root,arCOG00406@2157|Archaea,2XTRE@28890|Euryarchaeota,2460D@183980|Archaeoglobi	183980|Archaeoglobi	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.23	ko:K09759	ko00970,map00970	M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
SX3_k127_2589802_7	673860.AciM339_1472	1.704e-50	191.0	COG2404@1|root,arCOG00423@2157|Archaea,2Y6YG@28890|Euryarchaeota,3F2WE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	phosphohydrolase (DHH superfamily)	-	-	-	ko:K07097	-	-	-	-	ko00000	-	-	-	-
SX3_k127_2589802_5	1380408.AVGH01000040_gene2968	3.228e-67	237.0	COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,4HAAJ@91061|Bacilli,21WRM@150247|Anoxybacillus	91061|Bacilli	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	iYO844.BSU39420	DeoC
SX3_k127_2589802_15	439481.Aboo_1462	3.705e-06	60.0	COG1572@1|root,COG4934@1|root,arCOG02532@2157|Archaea,arCOG03669@2157|Archaea,2Y7X2@28890|Euryarchaeota,3F35Y@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Pro-kumamolisin, activation domain	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,CarboxypepD_reg,Pro-kuma_activ
SX3_k127_2589802_11	68223.JNZY01000037_gene7495	7.552e-30	139.0	COG1520@1|root,COG1520@2|Bacteria,2IAZ2@201174|Actinobacteria	201174|Actinobacteria	KLT	PQQ enzyme repeat	-	-	1.1.2.6,2.7.11.1	ko:K05889,ko:K12132	-	-	R03136	-	ko00000,ko01000,ko01001	-	-	-	PQQ,PQQ_2,PQQ_3,Pkinase
SX3_k127_2589802_16	1150474.JQJI01000006_gene839	8.716e-06	60.0	COG1388@1|root,COG4733@1|root,COG1388@2|Bacteria,COG4733@2|Bacteria,2GE91@200918|Thermotogae	2|Bacteria	M	Fibronectin type III domain	-	-	-	ko:K03933	-	-	-	-	ko00000	-	AA10,CBM73	-	Bac_DNA_binding,CHAP,fn3
SX3_k127_2607636_4	401526.TcarDRAFT_1254	1.514e-10	63.0	COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,4H28A@909932|Negativicutes	909932|Negativicutes	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
SX3_k127_2607636_0	1167006.UWK_00804	1.009e-37	150.0	COG1832@1|root,COG1832@2|Bacteria,1N03D@1224|Proteobacteria,42TZA@68525|delta/epsilon subdivisions,2WRHK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	CoA-binding domain protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
SX3_k127_2607636_3	1121104.AQXH01000001_gene1443	2.591e-25	107.0	COG0724@1|root,COG0724@2|Bacteria,4NV5J@976|Bacteroidetes	976|Bacteroidetes	S	RNA-binding protein	ykfA	-	-	-	-	-	-	-	-	-	-	-	RRM_1
SX3_k127_2607636_1	472759.Nhal_3535	4.619e-31	127.0	COG0748@1|root,COG0748@2|Bacteria,1N6EJ@1224|Proteobacteria	1224|Proteobacteria	P	Pfam Pyridoxamine 5'-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
SX3_k127_2607636_2	926569.ANT_31340	1.262e-26	111.0	COG0724@1|root,COG0724@2|Bacteria,2G74A@200795|Chloroflexi	200795|Chloroflexi	S	PFAM RNP-1 like RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
SX3_k127_2618228_2	443144.GM21_0478	4.635e-62	229.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NK7@68525|delta/epsilon subdivisions,2WKTV@28221|Deltaproteobacteria,43RYC@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
SX3_k127_2618228_0	1120985.AUMI01000017_gene2680	5.93e-172	554.0	COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,4H34D@909932|Negativicutes	909932|Negativicutes	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
SX3_k127_2618228_1	338963.Pcar_1292	3.081e-68	240.0	COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,42R30@68525|delta/epsilon subdivisions,2WJT0@28221|Deltaproteobacteria,43SE3@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Formyl transferase	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
SX3_k127_2621581_1	1192034.CAP_5621	4.635e-71	271.0	COG1948@1|root,COG5276@1|root,COG4880@2|Bacteria,COG5276@2|Bacteria,1P2CI@1224|Proteobacteria	1224|Proteobacteria	L	Beta propeller domain	-	-	-	-	-	-	-	-	-	-	-	-	Beta_propel
SX3_k127_2621581_2	269797.Mbar_A3325	3.011e-43	177.0	arCOG02527@1|root,arCOG02527@2157|Archaea	269797.Mbar_A3325|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2621581_4	1459636.NTE_00644	2.214e-22	103.0	arCOG07179@1|root,arCOG07179@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2621581_5	266117.Rxyl_0798	1.997e-19	94.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SX3_k127_2621581_9	68570.DC74_2470	0.0009976	49.0	2E4BC@1|root,32Z70@2|Bacteria,2GN4P@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4184)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4184
SX3_k127_2621581_3	1280390.CBQR020000145_gene3658	8.504e-27	114.0	COG0454@1|root,COG0456@2|Bacteria,1V86G@1239|Firmicutes,4HJIA@91061|Bacilli,26XJW@186822|Paenibacillaceae	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
SX3_k127_2621581_6	351160.RCIX1655	3.726e-11	68.0	COG0640@1|root,arCOG01680@2157|Archaea,2Y05Q@28890|Euryarchaeota,2NA1B@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM regulatory protein, ArsR	-	-	-	ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
SX3_k127_2621581_0	368407.Memar_0016	2.857e-128	419.0	COG0701@1|root,arCOG02712@2157|Archaea,2XVVT@28890|Euryarchaeota,2N9A7@224756|Methanomicrobia	224756|Methanomicrobia	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
SX3_k127_2621581_7	368407.Memar_0017	1.058e-10	72.0	arCOG03645@1|root,arCOG03645@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2621581_8	264732.Moth_2213	4.15e-05	51.0	COG4871@1|root,COG4871@2|Bacteria,1V7YF@1239|Firmicutes,24KYS@186801|Clostridia,42HHR@68295|Thermoanaerobacterales	186801|Clostridia	C	Putative Fe-S cluster	-	-	-	-	-	-	-	-	-	-	-	-	FeS
SX3_k127_2738300_0	439481.Aboo_0928	6.176e-100	349.0	COG1571@1|root,arCOG01115@2157|Archaea,2XTGD@28890|Euryarchaeota,3F2IS@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA	tiaS	GO:0002097,GO:0002101,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016879,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	6.3.4.22	ko:K06932	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1743,tRNA_anti-codon
SX3_k127_2744503_12	1041930.Mtc_1007	1.512e-49	188.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT0T@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_2744503_21	351160.RCIX1257	8.558e-06	59.0	COG0517@1|root,arCOG00606@2157|Archaea,2Y03P@28890|Euryarchaeota,2NBDT@224756|Methanomicrobia	224756|Methanomicrobia	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SX3_k127_2744503_4	1236689.MMALV_09870	2.958e-117	396.0	COG0358@1|root,arCOG04281@2157|Archaea,2XTHB@28890|Euryarchaeota,3F2FZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Toprim domain	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
SX3_k127_2744503_0	673860.AciM339_1562	9.923e-195	620.0	COG0466@1|root,arCOG02162@2157|Archaea,2XVMC@28890|Euryarchaeota,3F2HJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	AAA domain	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA_32,Mg_chelatase,Sigma54_activat
SX3_k127_2744503_16	300852.55771920	1.41e-28	130.0	COG0045@1|root,COG0045@2|Bacteria,1WIT1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
SX3_k127_2744503_9	1121468.AUBR01000005_gene78	7.619e-70	252.0	COG0074@1|root,COG0074@2|Bacteria,1TPIT@1239|Firmicutes,249MP@186801|Clostridia,42FV3@68295|Thermoanaerobacterales	186801|Clostridia	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA,Succ_CoA_lig
SX3_k127_2744503_18	349521.HCH_05643	1.122e-09	72.0	COG3209@1|root,COG3209@2|Bacteria,1QW4H@1224|Proteobacteria,1T42N@1236|Gammaproteobacteria,1XMP6@135619|Oceanospirillales	135619|Oceanospirillales	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
SX3_k127_2744503_6	1459636.NTE_03060	2.393e-104	349.0	COG1131@1|root,arCOG00196@2157|Archaea,41S73@651137|Thaumarchaeota	651137|Thaumarchaeota	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SX3_k127_2744503_8	456442.Mboo_0426	2.191e-71	253.0	COG0842@1|root,arCOG01467@2157|Archaea,2XU41@28890|Euryarchaeota,2N9R3@224756|Methanomicrobia	224756|Methanomicrobia	V	TIGRFAM daunorubicin resistance ABC transporter, inner membrane subunit B	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
SX3_k127_2744503_20	1151117.AJLF01000001_gene916	3.983e-07	64.0	COG1572@1|root,arCOG03260@1|root,arCOG03553@1|root,arCOG07560@1|root,arCOG02532@2157|Archaea,arCOG03260@2157|Archaea,arCOG03553@2157|Archaea,arCOG07560@2157|Archaea,2XZY0@28890|Euryarchaeota,243FB@183968|Thermococci	183968|Thermococci	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,PKD
SX3_k127_2744503_17	383372.Rcas_3732	9.189e-16	92.0	COG1470@1|root,COG1470@2|Bacteria,2GA7Y@200795|Chloroflexi,376PQ@32061|Chloroflexia	32061|Chloroflexia	M	SMART Parallel beta-helix repeat	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NPCBM_assoc
SX3_k127_2744503_14	589924.Ferp_0942	5.117e-39	164.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota,245SC@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S dicluster domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_17
SX3_k127_2744503_11	192952.MM_1291	6e-51	199.0	COG0277@1|root,arCOG00337@2157|Archaea,2XT5C@28890|Euryarchaeota,2N96T@224756|Methanomicrobia	224756|Methanomicrobia	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
SX3_k127_2744503_13	1379698.RBG1_1C00001G1092	2.514e-43	181.0	COG2866@1|root,COG4412@1|root,COG2866@2|Bacteria,COG4412@2|Bacteria,2NPI7@2323|unclassified Bacteria	2|Bacteria	E	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	3.4.17.18,3.4.17.22	ko:K05996,ko:K07752	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	F5_F8_type_C,Peptidase_M14,Peptidase_M6,Ricin_B_lectin,fn3
SX3_k127_2744503_19	1168034.FH5T_01790	9.898e-08	65.0	2AMSR@1|root,31CP7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2744503_10	502025.Hoch_3335	8.368e-56	224.0	COG1409@1|root,COG1409@2|Bacteria,1NS3S@1224|Proteobacteria,43AFC@68525|delta/epsilon subdivisions,2WSTQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
SX3_k127_2744503_3	673860.AciM339_1534	2.543e-130	442.0	COG4198@1|root,arCOG03573@2157|Archaea,2XZJQ@28890|Euryarchaeota,3F2MZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
SX3_k127_2744503_5	439481.Aboo_1421	2.844e-115	379.0	COG0111@1|root,arCOG01754@2157|Archaea,2XU9V@28890|Euryarchaeota,3F2JG@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
SX3_k127_2744503_7	272562.CA_C0014	7.9e-89	305.0	COG0075@1|root,COG0075@2|Bacteria,1TPS0@1239|Firmicutes,24919@186801|Clostridia,36E72@31979|Clostridiaceae	186801|Clostridia	E	Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
SX3_k127_2744503_2	768710.DesyoDRAFT_0694	3.107e-131	430.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,25ZZ5@186807|Peptococcaceae	186801|Clostridia	E	PFAM Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
SX3_k127_2744503_1	589924.Ferp_1532	4.318e-174	565.0	COG1980@1|root,arCOG04180@2157|Archaea,2XTI0@28890|Euryarchaeota,245YC@183980|Archaeoglobi	183980|Archaeoglobi	G	Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P)	fbp	-	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
SX3_k127_2744503_15	1121472.AQWN01000001_gene21	8.026e-33	136.0	COG1014@1|root,COG1014@2|Bacteria,1V3RG@1239|Firmicutes,24I3Y@186801|Clostridia,26231@186807|Peptococcaceae	186801|Clostridia	C	PFAM Pyruvate ferredoxin flavodoxin oxidoreductase	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
SX3_k127_2744503_22	1042877.GQS_02145	0.0002646	46.0	COG1013@1|root,arCOG01599@2157|Archaea,2XUSE@28890|Euryarchaeota,242ZV@183968|Thermococci	183968|Thermococci	C	ferredoxin oxidoreductase	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
SX3_k127_2757986_1	1094980.Mpsy_0730	4.532e-45	186.0	COG3291@1|root,COG3420@1|root,COG3979@1|root,arCOG02508@2157|Archaea,arCOG02519@2157|Archaea,arCOG02546@2157|Archaea,arCOG07581@2157|Archaea,2XUY6@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,PKD,Pilin_N,SdrD_B
SX3_k127_2757986_0	192952.MM_0425	1.676e-183	601.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,2N9A8@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
SX3_k127_2757986_5	1261545.MBE-HAL_1909	5.03e-11	70.0	COG1617@1|root,arCOG02197@2157|Archaea,2XXRY@28890|Euryarchaeota,23W8H@183963|Halobacteria	183963|Halobacteria	S	KEOPS complex Cgi121-like subunit	cgi121	-	-	ko:K09119	-	-	-	-	ko00000,ko03016	-	-	-	CGI-121
SX3_k127_2757986_2	1122921.KB898191_gene2007	1.809e-34	154.0	COG0457@1|root,COG3210@1|root,COG5492@1|root,COG0457@2|Bacteria,COG3210@2|Bacteria,COG5492@2|Bacteria,1UI3P@1239|Firmicutes,4HJMZ@91061|Bacilli,27713@186822|Paenibacillaceae	2|Bacteria	GN	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_2,Cadherin-like,CarboxypepD_reg,Flg_new,Laminin_G_3,PATR,SLH,fn3
SX3_k127_2757986_4	10228.TriadP37030	6.534e-16	93.0	KOG2437@1|root,KOG2437@2759|Eukaryota,38E9J@33154|Opisthokonta,3BFKC@33208|Metazoa	33208|Metazoa	T	actin cytoskeleton reorganization	MKLN1	GO:0000003,GO:0001556,GO:0001726,GO:0001952,GO:0003006,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005938,GO:0006996,GO:0007010,GO:0007154,GO:0007155,GO:0007160,GO:0007165,GO:0007276,GO:0007281,GO:0007292,GO:0008150,GO:0008360,GO:0009987,GO:0009994,GO:0010810,GO:0016043,GO:0019953,GO:0021700,GO:0022412,GO:0022414,GO:0022603,GO:0022604,GO:0022610,GO:0023052,GO:0030029,GO:0030036,GO:0030154,GO:0030155,GO:0031252,GO:0031532,GO:0031589,GO:0032501,GO:0032502,GO:0032504,GO:0042802,GO:0042995,GO:0044424,GO:0044444,GO:0044464,GO:0044703,GO:0048468,GO:0048469,GO:0048477,GO:0048599,GO:0048609,GO:0048856,GO:0048869,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0051704,GO:0051716,GO:0065007,GO:0065008,GO:0071695,GO:0071840,GO:0071944,GO:0099568,GO:0120025	-	-	-	-	-	-	-	-	-	-	Kelch_1,Kelch_3,Muskelin_N
SX3_k127_2757986_6	28072.Nos7524_5484	1.868e-09	72.0	COG2304@1|root,COG3209@1|root,COG3210@1|root,COG3266@1|root,COG5276@1|root,COG2304@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,COG3266@2|Bacteria,COG5276@2|Bacteria,1G4UG@1117|Cyanobacteria	1117|Cyanobacteria	M	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,RHS_repeat
SX3_k127_2757986_3	449447.MAE_31840	5.57e-34	151.0	COG1122@1|root,COG1196@1|root,COG1122@2|Bacteria,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	sidE	GO:0000338,GO:0003674,GO:0003824,GO:0003956,GO:0005575,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0009987,GO:0016567,GO:0016579,GO:0016740,GO:0016757,GO:0016763,GO:0016787,GO:0018995,GO:0019538,GO:0019783,GO:0019784,GO:0032446,GO:0036211,GO:0043170,GO:0043412,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0061578,GO:0070011,GO:0070536,GO:0070646,GO:0070647,GO:0071704,GO:0101005,GO:0140096,GO:1901564	-	ko:K02004,ko:K10110,ko:K15473,ko:K19171	ko02010,ko05134,map02010,map05134	M00194,M00258	-	-	ko00000,ko00001,ko00002,ko02000,ko02048	3.A.1,3.A.1.1.1,3.A.1.1.22	-	iLJ478.TM1202	AAA_23,BPD_transp_1,SidE
SX3_k127_2761504_17	439481.Aboo_0090	3.866e-18	88.0	COG1873@1|root,arCOG02155@2157|Archaea,2Y75P@28890|Euryarchaeota,3F3FQ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
SX3_k127_2761504_4	1236689.MMALV_00330	2.337e-179	565.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,3F2FH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
SX3_k127_2761504_19	589924.Ferp_1390	3.995e-09	61.0	COG3277@1|root,arCOG02466@2157|Archaea,2Y6CP@28890|Euryarchaeota,247G4@183980|Archaeoglobi	183980|Archaeoglobi	J	RNA-binding protein involved in rRNA processing	-	-	-	ko:K07569	-	-	-	-	ko00000,ko03009	-	-	-	-
SX3_k127_2761504_15	673860.AciM339_1385	1.414e-27	122.0	COG0071@1|root,arCOG01833@2157|Archaea,2XY1D@28890|Euryarchaeota,3F2SN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Belongs to the small heat shock protein (HSP20) family	hsp20b	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
SX3_k127_2761504_0	673860.AciM339_0643	4.4e-323	1004.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,3F39E@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
SX3_k127_2761504_7	5888.CAK91022	5.307e-66	251.0	COG3914@1|root,KOG4626@2759|Eukaryota,3ZDCY@5878|Ciliophora	5878|Ciliophora	GOT	TPR Domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
SX3_k127_2761504_6	1236689.MMALV_10860	2.276e-67	241.0	COG0492@1|root,arCOG01296@2157|Archaea,2XTJW@28890|Euryarchaeota,3F2RU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Pyridine nucleotide-disulphide oxidoreductase	trxB	-	1.18.1.2,1.19.1.1,1.8.1.9	ko:K00384,ko:K03387,ko:K21567	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Glutaredoxin,Pyr_redox_2
SX3_k127_2761504_16	635013.TherJR_2859	9.835e-22	114.0	COG4412@1|root,COG5184@1|root,COG5492@1|root,COG4412@2|Bacteria,COG5184@2|Bacteria,COG5492@2|Bacteria,1TS5I@1239|Firmicutes,24A8Z@186801|Clostridia,261X1@186807|Peptococcaceae	186801|Clostridia	DZ	regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_2,CHB_HEX_C_1,CW_binding_2,Cu_amine_oxidN1,RCC1,RCC1_2
SX3_k127_2761504_10	1408473.JHXO01000015_gene1906	2.874e-46	196.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	nanA	GO:0001573,GO:0003674,GO:0003824,GO:0004308,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006672,GO:0006687,GO:0006689,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0016020,GO:0016042,GO:0016052,GO:0016787,GO:0016798,GO:0016997,GO:0019377,GO:0030149,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044424,GO:0044464,GO:0046466,GO:0046479,GO:0046514,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1903509	3.2.1.18	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	-	R04018	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33	-	BNR_2,Gram_pos_anchor,Sialidase,YSIRK_signal
SX3_k127_2761504_14	981369.JQMJ01000003_gene8071	1.359e-29	140.0	COG1957@1|root,COG3291@1|root,COG1957@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF11,IU_nuc_hydro,PKD,SprB,fn3
SX3_k127_2761504_18	525904.Tter_2098	1.711e-11	80.0	COG4733@1|root,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	CelD_N,Glyco_hydro_9,fn3
SX3_k127_2761504_20	744872.Spica_1053	9.905e-07	64.0	COG2208@1|root,COG2208@2|Bacteria,2J5MN@203691|Spirochaetes	203691|Spirochaetes	KT	Stage II sporulation protein E	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,SpoIIE
SX3_k127_2761504_12	926550.CLDAP_33710	5.908e-40	175.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
SX3_k127_2761504_3	1041930.Mtc_2209	1.371e-186	606.0	COG0550@1|root,arCOG01527@2157|Archaea,arCOG06233@2157|Archaea,2XU6T@28890|Euryarchaeota,2N96B@224756|Methanomicrobia	224756|Methanomicrobia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	HHH_5,Topoisom_bac,Toprim,zf-C4_Topoisom
SX3_k127_2761504_1	635013.TherJR_0525	1.468e-281	878.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1TPHC@1239|Firmicutes,247V0@186801|Clostridia,260IW@186807|Peptococcaceae	186801|Clostridia	C	PFAM Acetyl-CoA hydrolase transferase	cat	-	-	ko:K18122	ko00650,ko01100,ko01200,map00650,map01100,map01200	-	R05336	RC00012,RC00014	ko00000,ko00001,ko01000	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
SX3_k127_2761504_5	926569.ANT_16580	1.712e-169	556.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2G5QB@200795|Chloroflexi	200795|Chloroflexi	C	PFAM CoA-binding domain protein	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
SX3_k127_2761504_11	351160.RCIX223	7.59e-43	170.0	COG0857@1|root,arCOG00099@2157|Archaea,2XU0G@28890|Euryarchaeota,2NAJ3@224756|Methanomicrobia	224756|Methanomicrobia	C	DRTGG domain	-	-	-	ko:K06873	-	-	-	-	ko00000	-	-	-	AAA_26,DRTGG
SX3_k127_2761504_2	368408.Tpen_0893	2.196e-244	773.0	COG0365@1|root,arCOG04201@2157|Archaea,2XSQM@28889|Crenarchaeota	28889|Crenarchaeota	I	PFAM AMP-dependent synthetase and ligase	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
SX3_k127_2761504_8	868131.MSWAN_0552	2.633e-64	231.0	COG1091@1|root,arCOG01367@2157|Archaea,2XVV7@28890|Euryarchaeota,23PC7@183925|Methanobacteria	183925|Methanobacteria	M	Male sterility protein	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
SX3_k127_2761504_9	1041930.Mtc_0357	6.325e-61	216.0	COG2101@1|root,arCOG01764@2157|Archaea,2XTTR@28890|Euryarchaeota,2N9N0@224756|Methanomicrobia	224756|Methanomicrobia	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	tbpE	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
SX3_k127_2761504_13	868131.MSWAN_0553	6.976e-35	134.0	COG1209@1|root,arCOG00667@2157|Archaea,2Y87B@28890|Euryarchaeota,23PGW@183925|Methanobacteria	183925|Methanobacteria	M	Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
SX3_k127_2763186_0	1123508.JH636439_gene600	0.0	1056.0	COG2755@1|root,COG5306@1|root,COG2755@2|Bacteria,COG5306@2|Bacteria,2IYTG@203682|Planctomycetes	203682|Planctomycetes	E	Domain of unknown function (DUF2341)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2341,Laminin_G_3,SASA
SX3_k127_2763186_1	497964.CfE428DRAFT_5409	3.917e-30	126.0	COG3119@1|root,COG3119@2|Bacteria,46SBA@74201|Verrucomicrobia	74201|Verrucomicrobia	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
SX3_k127_2785010_2	443143.GM18_2743	2.595e-13	70.0	COG0842@1|root,COG0842@2|Bacteria,1Q99P@1224|Proteobacteria,42M53@68525|delta/epsilon subdivisions,2WMEY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
SX3_k127_2785010_0	234267.Acid_7234	3.626e-56	225.0	COG0457@1|root,COG0457@2|Bacteria,3Y5ID@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2785010_4	69279.BG36_11120	2.772e-06	61.0	COG1470@1|root,COG1470@2|Bacteria,1R8IF@1224|Proteobacteria,2U1RT@28211|Alphaproteobacteria,43I30@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	NPCBM-associated, NEW3 domain of alpha-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	NPCBM_assoc
SX3_k127_2785010_1	1236689.MMALV_10380	1.97e-49	190.0	COG2516@1|root,arCOG00662@2157|Archaea,2XV52@28890|Euryarchaeota	28890|Euryarchaeota	S	Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SX3_k127_2785010_3	673860.AciM339_0684	1.178e-08	61.0	arCOG08126@1|root,arCOG08126@2157|Archaea,2Y74U@28890|Euryarchaeota,3F3EE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2828332_6	1094980.Mpsy_3151	7.057e-09	65.0	COG5520@1|root,arCOG03769@1|root,arCOG07561@1|root,arCOG03769@2157|Archaea,arCOG07561@2157|Archaea,arCOG09138@2157|Archaea,2XV3J@28890|Euryarchaeota,2NBAU@224756|Methanomicrobia	224756|Methanomicrobia	K	glycoside hydrolase, family	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2828332_0	596151.DesfrDRAFT_4143	8.495e-169	547.0	COG0492@1|root,COG0526@1|root,COG0492@2|Bacteria,COG0526@2|Bacteria,1R05R@1224|Proteobacteria,42QEV@68525|delta/epsilon subdivisions,2X8DS@28221|Deltaproteobacteria,2MH5Z@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Thioredoxin_3
SX3_k127_2828332_3	690850.Desaf_2377	1.449e-23	102.0	COG0695@1|root,COG0695@2|Bacteria,1NAZM@1224|Proteobacteria,42VIA@68525|delta/epsilon subdivisions,2WR8X@28221|Deltaproteobacteria,2MDCB@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	PFAM glutaredoxin	-	-	-	ko:K06191	-	-	-	-	ko00000	-	-	-	Glutaredoxin
SX3_k127_2828332_2	351160.RCIX2472	9.822e-55	197.0	COG4802@1|root,arCOG01100@2157|Archaea,2Y3RU@28890|Euryarchaeota,2NATY@224756|Methanomicrobia	224756|Methanomicrobia	C	Ferredoxin thioredoxin reductase catalytic beta chain	-	-	-	-	-	-	-	-	-	-	-	-	FeThRed_B
SX3_k127_2828332_5	548477.HMPREF0294_0332	6.397e-12	78.0	COG2885@1|root,COG3266@1|root,COG2885@2|Bacteria,COG3266@2|Bacteria,2I6XH@201174|Actinobacteria,22MTB@1653|Corynebacteriaceae	2|Bacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,G5,TSP_3,YSIRK_signal
SX3_k127_2828332_4	1120999.JONM01000012_gene2242	5.563e-22	113.0	COG0823@1|root,COG0841@1|root,COG1361@1|root,COG1572@1|root,COG1657@1|root,COG2373@1|root,COG4733@1|root,COG0823@2|Bacteria,COG0841@2|Bacteria,COG1361@2|Bacteria,COG1572@2|Bacteria,COG1657@2|Bacteria,COG2373@2|Bacteria,COG4733@2|Bacteria,1QV7E@1224|Proteobacteria,2WHIN@28216|Betaproteobacteria	28216|Betaproteobacteria	M	TIGRFAM Outer membrane protein	-	-	-	ko:K13735,ko:K20276	ko02024,ko05100,map02024,map05100	-	-	-	ko00000,ko00001	-	-	-	Big_3_2
SX3_k127_2828332_7	1379698.RBG1_1C00001G1789	1.619e-07	66.0	COG1572@1|root,COG1572@2|Bacteria,2NP03@2323|unclassified Bacteria	2|Bacteria	S	Propeptide_C25	porU	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C25
SX3_k127_2828332_1	1220534.B655_0208	1.157e-66	231.0	COG0655@1|root,arCOG02573@2157|Archaea,2XWPJ@28890|Euryarchaeota,23PIC@183925|Methanobacteria	183925|Methanobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
SX3_k127_2835285_13	529709.PYCH_01100	3.292e-43	163.0	COG0315@1|root,arCOG01530@2157|Archaea,2XWHQ@28890|Euryarchaeota,243UY@183968|Thermococci	183968|Thermococci	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
SX3_k127_2835285_12	218284.CCDN010000008_gene4235	1.953e-45	169.0	COG0521@1|root,COG0521@2|Bacteria,1V3XM@1239|Firmicutes,4HH5V@91061|Bacilli,1ZFK1@1386|Bacillus	91061|Bacilli	H	May be involved in the biosynthesis of molybdopterin	moaB	-	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
SX3_k127_2835285_1	351160.RCIX2263	3.862e-163	523.0	COG0426@1|root,arCOG00509@2157|Archaea,2XSUD@28890|Euryarchaeota,2N90R@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Lactamase_B
SX3_k127_2835285_6	1094508.Tsac_0413	2.88e-103	349.0	COG2461@1|root,COG2461@2|Bacteria,1TRD5@1239|Firmicutes,24CKX@186801|Clostridia,42FM8@68295|Thermoanaerobacterales	186801|Clostridia	S	Family of unknown function (DUF438)	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF1858,DUF438,Hemerythrin,PAS_10
SX3_k127_2835285_18	768706.Desor_4116	9.333e-14	74.0	COG2461@1|root,COG2461@2|Bacteria,1TRD5@1239|Firmicutes,24CKX@186801|Clostridia,26100@186807|Peptococcaceae	186801|Clostridia	S	Hemerythrin HHE cation binding domain	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF1858,DUF438,Hemerythrin,PAS_10
SX3_k127_2835285_0	351160.RCIX2090	9.249e-166	546.0	COG2414@1|root,arCOG00707@2157|Archaea,2Y7HH@28890|Euryarchaeota,2NBK1@224756|Methanomicrobia	224756|Methanomicrobia	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	aor-1	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
SX3_k127_2835285_14	345341.KUTG_03516	2.286e-32	143.0	COG0477@1|root,COG2814@2|Bacteria,2I9WU@201174|Actinobacteria,4DZYN@85010|Pseudonocardiales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX3_k127_2835285_2	673860.AciM339_1443	4.517e-137	450.0	COG0608@1|root,arCOG00427@2157|Archaea,2XT8Y@28890|Euryarchaeota,3F2FV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	DHHA1 domain	recJ	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHHA1
SX3_k127_2835285_17	383372.Rcas_2923	3.386e-14	77.0	COG0314@1|root,COG1977@1|root,COG0314@2|Bacteria,COG1977@2|Bacteria,2G6YQ@200795|Chloroflexi,376I2@32061|Chloroflexia	32061|Chloroflexia	H	PFAM molybdopterin biosynthesis MoaE protein	moaD	-	2.8.1.12	ko:K03635,ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE,ThiS
SX3_k127_2835285_21	1054217.TALC_01343	1.352e-08	66.0	COG3255@1|root,arCOG01843@2157|Archaea,2Y0F9@28890|Euryarchaeota,241WX@183967|Thermoplasmata	183967|Thermoplasmata	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
SX3_k127_2835285_11	439481.Aboo_0956	6.827e-50	187.0	COG0164@1|root,arCOG04121@2157|Archaea,2XWYC@28890|Euryarchaeota,3F2N8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
SX3_k127_2835285_15	1054217.TALC_00939	3.21e-30	128.0	COG1585@1|root,arCOG01912@2157|Archaea,2Y07X@28890|Euryarchaeota	28890|Euryarchaeota	O	NfeD-like C-terminal, partner-binding	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
SX3_k127_2835285_3	1041930.Mtc_1205	3.607e-133	435.0	COG0330@1|root,arCOG01915@2157|Archaea,2XTA2@28890|Euryarchaeota,2N9RK@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
SX3_k127_2835285_10	439235.Dalk_5067	3.565e-65	235.0	COG2048@1|root,COG2048@2|Bacteria,1RC7G@1224|Proteobacteria,43B85@68525|delta/epsilon subdivisions,2WMVG@28221|Deltaproteobacteria,2MJQR@213118|Desulfobacterales	28221|Deltaproteobacteria	C	heterodisulfide reductase, subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
SX3_k127_2835285_16	264732.Moth_1196	1.97e-16	86.0	COG1150@1|root,COG1150@2|Bacteria,1TU86@1239|Firmicutes,2590C@186801|Clostridia,42IEZ@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_17
SX3_k127_2835285_9	1121396.KB893058_gene2561	7.377e-79	279.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2MIMJ@213118|Desulfobacterales	28221|Deltaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SX3_k127_2835285_22	1054217.TALC_01307	1.967e-07	63.0	arCOG14714@1|root,arCOG14714@2157|Archaea,2Y2VC@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2835285_5	574375.BAGA_18610	8.66e-125	407.0	COG0604@1|root,COG0604@2|Bacteria,1TSWF@1239|Firmicutes,4HANV@91061|Bacilli,1ZPZP@1386|Bacillus	91061|Bacilli	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
SX3_k127_2835285_4	574375.BAGA_18610	2.24e-127	415.0	COG0604@1|root,COG0604@2|Bacteria,1TSWF@1239|Firmicutes,4HANV@91061|Bacilli,1ZPZP@1386|Bacillus	91061|Bacilli	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
SX3_k127_2835285_19	1047013.AQSP01000128_gene413	4.453e-13	79.0	2DU2Y@1|root,33NQT@2|Bacteria	2|Bacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_4
SX3_k127_2835285_7	575540.Isop_2113	6.094e-94	322.0	COG1131@1|root,COG1131@2|Bacteria,2IZF2@203682|Planctomycetes	203682|Planctomycetes	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_2835285_20	1047013.AQSP01000128_gene415	1.207e-12	81.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	nosY	-	-	ko:K01992,ko:K19341	ko02010,map02010	M00254,M00762	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.132.2	-	-	ABC2_membrane_2
SX3_k127_2835285_8	1210884.HG799462_gene8049	8.897e-83	285.0	COG1131@1|root,COG1131@2|Bacteria,2IZ5V@203682|Planctomycetes	203682|Planctomycetes	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_2858807_0	406124.ACPC01000017_gene625	8.325e-56	217.0	COG1404@1|root,COG1404@2|Bacteria,1TQRU@1239|Firmicutes,4HAZA@91061|Bacilli,1ZAZK@1386|Bacillus	91061|Bacilli	O	Belongs to the peptidase S8 family	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S8
SX3_k127_2887087_8	1216007.AOPM01000073_gene1364	2.42e-08	65.0	COG1520@1|root,COG1520@2|Bacteria,1RB08@1224|Proteobacteria,1S2SZ@1236|Gammaproteobacteria,2Q47M@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
SX3_k127_2887087_6	443143.GM18_0928	3.276e-23	107.0	COG4393@1|root,COG4393@2|Bacteria,1R507@1224|Proteobacteria,42NQA@68525|delta/epsilon subdivisions,2WQ0C@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Predicted membrane protein (DUF2318)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2318
SX3_k127_2887087_5	269799.Gmet_1554	7.601e-27	117.0	COG4393@1|root,COG4393@2|Bacteria,1R507@1224|Proteobacteria,42NQA@68525|delta/epsilon subdivisions,2WQ0C@28221|Deltaproteobacteria,43UZR@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Predicted membrane protein (DUF2318)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2318
SX3_k127_2887087_1	717231.Flexsi_1874	2.454e-75	259.0	COG1136@1|root,COG1136@2|Bacteria,2GFQJ@200930|Deferribacteres	200930|Deferribacteres	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_2887087_3	1034769.KB910518_gene319	6.692e-63	232.0	COG0577@1|root,COG0577@2|Bacteria,1TSK6@1239|Firmicutes,4HUMQ@91061|Bacilli,270X4@186822|Paenibacillaceae	91061|Bacilli	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX3_k127_2887087_7	309800.C498_06453	9.661e-14	76.0	arCOG08981@1|root,arCOG08981@2157|Archaea,2Y00W@28890|Euryarchaeota,23Y5Q@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2887087_4	386456.JQKN01000014_gene3085	1.799e-29	123.0	COG0640@1|root,arCOG00731@2157|Archaea,2XYSK@28890|Euryarchaeota	28890|Euryarchaeota	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
SX3_k127_2887087_0	304371.MCP_1025	4.218e-121	404.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,2N9CZ@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
SX3_k127_2887087_2	1041930.Mtc_1926	7.499e-69	253.0	COG0312@1|root,arCOG00322@2157|Archaea,2XV41@28890|Euryarchaeota,2N939@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
SX3_k127_2917104_4	1087448.Eab7_2831	1.055e-40	162.0	COG1235@1|root,COG1235@2|Bacteria,1TQ8E@1239|Firmicutes,4HAKD@91061|Bacilli,3WEPS@539002|Bacillales incertae sedis	91061|Bacilli	S	Metallo-beta-lactamase superfamily	vicX	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B,Lactamase_B_2
SX3_k127_2917104_0	706587.Desti_0036	2.814e-274	869.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,42NFG@68525|delta/epsilon subdivisions,2WJGA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
SX3_k127_2917104_8	1121440.AUMA01000003_gene2984	6.384e-30	121.0	COG1324@1|root,COG1324@2|Bacteria,1N6TN@1224|Proteobacteria,42VE1@68525|delta/epsilon subdivisions,2WR7D@28221|Deltaproteobacteria,2MDG6@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM CutA1 divalent ion tolerance protein	cutA	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
SX3_k127_2917104_9	273116.14324649	4.221e-23	111.0	arCOG03678@1|root,arCOG03677@2157|Archaea,2Y0K5@28890|Euryarchaeota,242AH@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2917104_10	439481.Aboo_0139	4.25e-23	115.0	COG4906@1|root,arCOG00568@2157|Archaea	2157|Archaea	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2206
SX3_k127_2917104_7	877455.Metbo_1834	1.595e-36	158.0	COG0457@1|root,arCOG03038@2157|Archaea,2XUNW@28890|Euryarchaeota	28890|Euryarchaeota	O	TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
SX3_k127_2917104_11	1123401.JHYQ01000009_gene2298	4.108e-07	63.0	COG2885@1|root,COG2885@2|Bacteria,1R508@1224|Proteobacteria,1RS7G@1236|Gammaproteobacteria,46256@72273|Thiotrichales	72273|Thiotrichales	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
SX3_k127_2917104_6	351160.LRC269	2.683e-37	151.0	COG1096@1|root,arCOG00676@2157|Archaea,2XYYA@28890|Euryarchaeota,2N9T0@224756|Methanomicrobia	224756|Methanomicrobia	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs	csl4	-	-	ko:K07573	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,EXOSC1
SX3_k127_2917104_3	386456.JQKN01000001_gene1765	1.23e-42	178.0	COG2263@1|root,arCOG00910@2157|Archaea,2XU4P@28890|Euryarchaeota,23PIV@183925|Methanobacteria	183925|Methanobacteria	Q	Ribosomal protein L11 methyltransferase (PrmA)	prmA	-	-	ko:K07579	-	-	-	-	ko00000	-	-	-	MTS,PrmA
SX3_k127_2917104_1	1236689.MMALV_16330	2.312e-140	463.0	COG0151@1|root,arCOG04415@2157|Archaea,2XTRV@28890|Euryarchaeota,3F2H0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Phosphoribosylglycinamide synthetase, C domain	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A3513	GARS_A,GARS_C,GARS_N
SX3_k127_2917104_2	573063.Metin_0691	1.204e-43	164.0	COG0461@1|root,arCOG00029@2157|Archaea,2XVNG@28890|Euryarchaeota,23QT7@183939|Methanococci	183939|Methanococci	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
SX3_k127_2917104_5	1054217.TALC_00225	6.654e-38	148.0	COG0575@1|root,arCOG04106@2157|Archaea,2XWNR@28890|Euryarchaeota,241V9@183967|Thermoplasmata	183967|Thermoplasmata	I	Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids	carS	-	2.7.7.67	ko:K19664	ko00564,map00564	-	R08966	RC00002	ko00000,ko00001,ko01000	-	-	-	CarS-like
SX3_k127_2932927_0	991905.SL003B_3564	5.068e-106	374.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,2U12Y@28211|Alphaproteobacteria,4BRG6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
SX3_k127_2940063_0	264732.Moth_0443	2.47e-107	360.0	COG0095@1|root,COG1852@1|root,COG0095@2|Bacteria,COG1852@2|Bacteria,1TQ5U@1239|Firmicutes,247S9@186801|Clostridia,42ET4@68295|Thermoanaerobacterales	186801|Clostridia	H	biotin lipoate A B protein ligase	lipM	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
SX3_k127_2940063_1	374847.Kcr_0385	9.585e-18	88.0	COG1470@1|root,arCOG03511@1|root,arCOG07813@1|root,arCOG02087@2157|Archaea,arCOG03511@2157|Archaea,arCOG07813@2157|Archaea	2157|Archaea	C	LamG domain protein jellyroll fold domain protein	-	-	2.4.99.18,3.5.1.56	ko:K03418,ko:K07151	ko00510,ko00513,ko00630,ko01100,ko04141,map00510,map00513,map00630,map01100,map04141	M00072	R02509,R04216,R05976	RC00005,RC00111,RC00482,RC00731	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	CarboxypepD_reg,DUF2341,Laminin_G_3,PKD,Pilin_N,STT3
SX3_k127_2943062_0	1254432.SCE1572_43675	1.255e-44	166.0	COG2885@1|root,COG2885@2|Bacteria,1R7WJ@1224|Proteobacteria,42QJK@68525|delta/epsilon subdivisions,2WJX0@28221|Deltaproteobacteria,2YWI7@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,TSP_3
SX3_k127_2943071_6	1273538.G159_13760	2.301e-13	72.0	COG1246@1|root,COG1846@1|root,COG1246@2|Bacteria,COG1846@2|Bacteria,1UZW1@1239|Firmicutes,4HD5Y@91061|Bacilli,26E30@186818|Planococcaceae	91061|Bacilli	K	MarR family	ybfA1	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,MarR,MarR_2
SX3_k127_2943071_1	1449126.JQKL01000033_gene1186	1.525e-123	408.0	COG0115@1|root,COG0115@2|Bacteria,1TQQI@1239|Firmicutes,2480D@186801|Clostridia,267MC@186813|unclassified Clostridiales	186801|Clostridia	EH	Amino-transferase class IV	ilvE	-	2.6.1.42,4.1.3.38	ko:K00826,ko:K02619	ko00270,ko00280,ko00290,ko00770,ko00790,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map00790,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R05553,R10991	RC00006,RC00036,RC01843,RC02148	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
SX3_k127_2943071_2	880073.Calab_0825	2.08e-43	182.0	COG1404@1|root,COG3637@1|root,COG1404@2|Bacteria,COG3637@2|Bacteria,2NPDC@2323|unclassified Bacteria	2|Bacteria	O	Peptidase S8	-	-	3.4.21.66	ko:K08651	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	DUF3138,Peptidase_S8
SX3_k127_2943071_8	215803.DB30_3755	2.879e-05	53.0	COG0454@1|root,COG0456@2|Bacteria,1N2EC@1224|Proteobacteria,437FF@68525|delta/epsilon subdivisions,2X2N2@28221|Deltaproteobacteria,2YZX8@29|Myxococcales	28221|Deltaproteobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SX3_k127_2943071_4	1463821.JOGR01000001_gene1235	3.267e-21	104.0	COG0382@1|root,COG0382@2|Bacteria,2IJV5@201174|Actinobacteria	201174|Actinobacteria	H	UbiA prenyltransferase family	-	-	2.5.1.133,2.5.1.62	ko:K04040	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06284,R09067,R11514,R11517	RC00020	ko00000,ko00001,ko01000,ko01006	-	-	-	UbiA
SX3_k127_2943071_3	931626.Awo_c33250	2.217e-28	119.0	2DH26@1|root,2ZY4Z@2|Bacteria,1V3J9@1239|Firmicutes,24HRK@186801|Clostridia,25ZM9@186806|Eubacteriaceae	186801|Clostridia	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
SX3_k127_2943071_5	694427.Palpr_0366	1.27e-16	85.0	COG2832@1|root,COG2832@2|Bacteria,4NS6H@976|Bacteroidetes,2FSGM@200643|Bacteroidia,22YP7@171551|Porphyromonadaceae	976|Bacteroidetes	S	Protein of unknown function (DUF454)	-	-	-	ko:K09790	-	-	-	-	ko00000	-	-	-	DUF454
SX3_k127_2943071_0	523845.AQXV01000019_gene364	4.564e-243	777.0	COG0474@1|root,arCOG01578@2157|Archaea,2XT4B@28890|Euryarchaeota,23QDK@183939|Methanococci	183939|Methanococci	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
SX3_k127_2943071_7	351160.RCIX2657	2.549e-12	72.0	COG1575@1|root,arCOG00480@2157|Archaea,2XXM6@28890|Euryarchaeota	28890|Euryarchaeota	H	PFAM UbiA prenyltransferase	-	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
SX3_k127_2944066_0	391625.PPSIR1_35652	6.713e-85	311.0	COG0433@1|root,COG0433@2|Bacteria,1R7B1@1224|Proteobacteria,42NW4@68525|delta/epsilon subdivisions,2X6WX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2944066_1	420247.Msm_0993	2.573e-05	54.0	arCOG12756@1|root,arCOG12756@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_2976992_0	264732.Moth_0887	1.838e-218	708.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,42EJU@68295|Thermoanaerobacterales	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
SX3_k127_2976992_2	553175.POREN0001_0108	1.318e-22	114.0	COG1297@1|root,COG1297@2|Bacteria,4NEIY@976|Bacteroidetes,2FN5W@200643|Bacteroidia,22W0A@171551|Porphyromonadaceae	976|Bacteroidetes	S	Peptide transporter	-	-	-	-	-	-	-	-	-	-	-	-	OPT
SX3_k127_2976992_1	1300143.CCAV010000001_gene1606	1.617e-23	104.0	COG0399@1|root,COG0399@2|Bacteria,4PKRF@976|Bacteroidetes,1I2SV@117743|Flavobacteriia,3ZS3U@59732|Chryseobacterium	976|Bacteroidetes	J	S23 ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
SX3_k127_3001560_9	91464.S7335_1502	3.569e-53	216.0	COG2931@1|root,COG2931@2|Bacteria,1G2GC@1117|Cyanobacteria,1H46I@1129|Synechococcus	1117|Cyanobacteria	Q	Q COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,HemolysinCabind
SX3_k127_3001560_11	1219076.N646_3965	1.46e-10	76.0	COG2304@1|root,COG2931@1|root,COG3637@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,COG3637@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,1Y3D6@135623|Vibrionales	135623|Vibrionales	Q	Putative Ig domain	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG
SX3_k127_3001560_6	1121423.JONT01000008_gene704	8.562e-66	239.0	COG1150@1|root,COG1150@2|Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	-	-	1.17.1.9	ko:K00125,ko:K03646	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000,ko02000	2.C.1.2	-	-	Fer4,Fer4_17,Fer4_8,FrhB_FdhB_C
SX3_k127_3001560_7	1125863.JAFN01000001_gene1777	1.748e-61	214.0	COG1908@1|root,COG1908@2|Bacteria,1RCZY@1224|Proteobacteria,42TFE@68525|delta/epsilon subdivisions,2WPDR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	FlpD
SX3_k127_3001560_3	429009.Adeg_1333	1.025e-113	396.0	COG1148@1|root,COG1148@2|Bacteria,1VPAD@1239|Firmicutes,25B2G@186801|Clostridia,42FM3@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Fer4,Fer4_7,Pyr_redox_2
SX3_k127_3001560_0	439235.Dalk_5090	8.295e-314	994.0	COG1018@1|root,COG1148@1|root,COG1018@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,Pyr_redox_2
SX3_k127_3001560_1	469381.Dpep_2021	3.248e-222	728.0	COG1894@1|root,COG1894@2|Bacteria,3TAJW@508458|Synergistetes	508458|Synergistetes	C	PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
SX3_k127_3001560_4	1499967.BAYZ01000171_gene5565	1.664e-86	296.0	COG1148@1|root,COG1905@1|root,COG1148@2|Bacteria,COG1905@2|Bacteria,2NPSB@2323|unclassified Bacteria	2|Bacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	bamG	-	1.6.5.3,1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K00334,ko:K03388	ko00190,ko00680,ko01100,ko01120,ko01200,map00190,map00680,map01100,map01120,map01200	M00144,M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944,R11945	RC00011,RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Fer4,NAD_binding_8,Pyr_redox_2,Response_reg
SX3_k127_3001560_5	706587.Desti_0172	4.377e-73	259.0	COG2048@1|root,COG2048@2|Bacteria,1RC7G@1224|Proteobacteria,43B85@68525|delta/epsilon subdivisions,2WMVG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Heterodisulfide reductase subunit B	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
SX3_k127_3001560_10	706587.Desti_0171	2.733e-37	149.0	COG1150@1|root,COG1150@2|Bacteria,1R44N@1224|Proteobacteria,42NTE@68525|delta/epsilon subdivisions,2WJN8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Nitrate reductase gamma subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	-
SX3_k127_3001560_13	1296415.JACC01000002_gene3181	0.0006718	52.0	COG3291@1|root,COG3397@1|root,COG4412@1|root,COG3291@2|Bacteria,COG3397@2|Bacteria,COG4412@2|Bacteria,4PHYH@976|Bacteroidetes,1IGDD@117743|Flavobacteriia,2YHN3@290174|Aquimarina	976|Bacteroidetes	G	Lytic polysaccharide mono-oxygenase, cellulose-degrading	-	-	-	-	-	-	-	-	-	-	-	-	LPMO_10,PKD
SX3_k127_3001560_2	673860.AciM339_1271	7.642e-187	599.0	COG4962@1|root,arCOG01817@2157|Archaea,2XTDM@28890|Euryarchaeota,3F31Q@33867|unclassified Euryarchaeota	28890|Euryarchaeota	N	Type II/IV secretion system protein	flaI	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
SX3_k127_3001560_8	1094980.Mpsy_2349	1.613e-57	211.0	COG2874@1|root,arCOG04148@2157|Archaea,2XUMD@28890|Euryarchaeota,2N9IB@224756|Methanomicrobia	224756|Methanomicrobia	N	KaiC	-	-	-	ko:K07331	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	ATPase
SX3_k127_3001560_12	63737.Npun_R0606	0.0001681	54.0	COG3420@1|root,COG3420@2|Bacteria,1G2FG@1117|Cyanobacteria,1HRTD@1161|Nostocales	1117|Cyanobacteria	P	Protein of unknown function (DUF1565)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1565,SLH
SX3_k127_3001806_17	1506994.JNLQ01000002_gene659	7.264e-06	52.0	COG4260@1|root,COG4260@2|Bacteria	2|Bacteria	N	virion core protein, lumpy skin disease virus	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DZR,SHOCT,zinc_ribbon_2
SX3_k127_3001806_4	391623.TERMP_01095	1.568e-48	181.0	COG2238@1|root,arCOG01344@2157|Archaea,2XXA6@28890|Euryarchaeota,242ZB@183968|Thermococci	183968|Thermococci	J	May be involved in maturation of the 30S ribosomal subunit	rps19e	-	-	ko:K02966	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19e
SX3_k127_3001806_11	439481.Aboo_0025	9.614e-22	98.0	COG2118@1|root,arCOG04179@2157|Archaea,2XZUR@28890|Euryarchaeota,3F2TE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Belongs to the PDCD5 family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K06875	-	-	-	-	ko00000	-	-	-	dsDNA_bind
SX3_k127_3001806_15	529709.PYCH_19080	5.178e-10	66.0	COG2167@1|root,arCOG04177@2157|Archaea,2XZSY@28890|Euryarchaeota,244NC@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL39 family	rpl39e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02924	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L39
SX3_k127_3001806_13	439481.Aboo_0027	3.997e-12	70.0	COG2097@1|root,arCOG04473@2157|Archaea,2XYWX@28890|Euryarchaeota,3F2SS@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the ribosomal protein L31e family	rpl31e	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02910	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31e
SX3_k127_3001806_5	1227487.C474_10751	3.084e-47	178.0	COG1976@1|root,arCOG04176@2157|Archaea,2XU7N@28890|Euryarchaeota,23SZE@183963|Halobacteria	183963|Halobacteria	J	Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex	eif6	-	-	ko:K03264	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009,ko03012	-	-	-	eIF-6
SX3_k127_3001806_3	1128421.JAGA01000004_gene2700	3.805e-54	205.0	COG1247@1|root,COG1247@2|Bacteria	2|Bacteria	M	phosphinothricin N-acetyltransferase activity	pat	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
SX3_k127_3001806_14	1173024.KI912149_gene5318	2.096e-10	73.0	COG2885@1|root,COG2885@2|Bacteria,1G2YF@1117|Cyanobacteria,1JGWQ@1189|Stigonemataceae	1117|Cyanobacteria	M	OmpA family	-	-	-	ko:K02557,ko:K03286	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1,1.B.6	-	-	OmpA
SX3_k127_3001806_6	459349.CLOAM0313	9.289e-45	190.0	COG1305@1|root,COG1305@2|Bacteria	2|Bacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_1,DUF3857,GBS_Bsp-like,Transglut_core
SX3_k127_3001806_8	1089550.ATTH01000001_gene1475	1.077e-27	133.0	COG2931@1|root,COG2931@2|Bacteria,4NFV5@976|Bacteroidetes,1FJUV@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	Q	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
SX3_k127_3001806_16	1449063.JMLS01000030_gene469	1.684e-06	63.0	2DBQW@1|root,2ZAH4@2|Bacteria,1UYN3@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3001806_9	1267533.KB906734_gene3785	6.316e-27	130.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	FlgD_ig,Kelch_4
SX3_k127_3001806_2	1286171.EAL2_808p03370	1.387e-77	284.0	COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,24CD5@186801|Clostridia,25ZF5@186806|Eubacteriaceae	186801|Clostridia	O	Subtilase family	isp	-	3.4.21.62	ko:K01342,ko:K13275	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Peptidase_S8
SX3_k127_3001806_10	525904.Tter_2049	2.042e-26	119.0	COG3634@1|root,COG3634@2|Bacteria	2|Bacteria	C	alkyl hydroperoxide reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
SX3_k127_3001806_1	1459636.NTE_02180	6.495e-95	318.0	COG1830@1|root,arCOG04044@2157|Archaea,41S64@651137|Thaumarchaeota	651137|Thaumarchaeota	E	DeoC/LacD family aldolase	-	-	2.3.1.245	ko:K08321	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000	-	-	-	DeoC
SX3_k127_3001806_0	247490.KSU1_C0515	9.344e-135	438.0	COG1063@1|root,COG1063@2|Bacteria,2J2DX@203682|Planctomycetes	203682|Planctomycetes	E	Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
SX3_k127_3001806_7	383372.Rcas_3603	1.985e-29	138.0	COG1100@1|root,COG1100@2|Bacteria,2G9IC@200795|Chloroflexi,3777W@32061|Chloroflexia	32061|Chloroflexia	S	SMART Ras small GTPase, Ras type	-	-	-	-	-	-	-	-	-	-	-	-	Ras
SX3_k127_3001806_12	765420.OSCT_2112	1.631e-13	85.0	COG0515@1|root,COG0515@2|Bacteria	765420.OSCT_2112|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3006776_1	871968.DESME_15100	2.434e-06	61.0	COG1629@1|root,COG2247@1|root,COG3391@1|root,COG2247@2|Bacteria,COG3391@2|Bacteria,COG4771@2|Bacteria,1V0RA@1239|Firmicutes,24AV7@186801|Clostridia,260Q2@186807|Peptococcaceae	186801|Clostridia	EM	cell wall binding repeat 2	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2,Lipase_GDSL_2,TIG
SX3_k127_3006776_0	1121422.AUMW01000016_gene2063	2.025e-07	64.0	COG5434@1|root,COG5434@2|Bacteria,1UJS5@1239|Firmicutes,24VP2@186801|Clostridia,266SC@186807|Peptococcaceae	186801|Clostridia	M	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
SX3_k127_3049864_5	28072.Nos7524_5484	5.617e-48	193.0	COG2304@1|root,COG3209@1|root,COG3210@1|root,COG3266@1|root,COG5276@1|root,COG2304@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,COG3266@2|Bacteria,COG5276@2|Bacteria,1G4UG@1117|Cyanobacteria	1117|Cyanobacteria	M	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,RHS_repeat
SX3_k127_3049864_6	1379698.RBG1_1C00001G1377	5.244e-38	162.0	COG4409@1|root,COG4409@2|Bacteria,2NRD7@2323|unclassified Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	ASH,BNR_2,Big_3_2,CBM_35,DUF1080,F5_F8_type_C,PKD,RicinB_lectin_2,Trehalase
SX3_k127_3049864_0	1236689.MMALV_03010	1.209e-96	321.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,3F2G0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019773,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
SX3_k127_3049864_3	439481.Aboo_0184	1.183e-77	266.0	COG1500@1|root,arCOG04187@2157|Archaea,2XTNH@28890|Euryarchaeota,3F2JN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Shwachman-Bodian-Diamond syndrome (SBDS) protein	-	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	ko:K14574	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	SBDS,SBDS_C
SX3_k127_3049864_4	673860.AciM339_0867	5.145e-60	226.0	COG1097@1|root,arCOG00678@2157|Archaea,2XWEN@28890|Euryarchaeota,3F2JY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome	rrp4	GO:0000178,GO:0000288,GO:0000291,GO:0000459,GO:0000460,GO:0000466,GO:0000467,GO:0000469,GO:0000956,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006364,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016180,GO:0019222,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0031126,GO:0032991,GO:0034470,GO:0034472,GO:0034475,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043144,GO:0043170,GO:0043628,GO:0043928,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071034,GO:0071043,GO:0071051,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354	-	ko:K03679	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,KH_1,KH_6,S1
SX3_k127_3049864_1	673860.AciM339_0868	6.589e-94	315.0	COG0689@1|root,arCOG01575@2157|Archaea,2XVHI@28890|Euryarchaeota,3F2GE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails	rrp41	GO:0000177,GO:0000178,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575,GO:1902494,GO:1905354	-	ko:K11600	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
SX3_k127_3049864_2	673860.AciM339_0869	4.9e-83	284.0	COG2123@1|root,arCOG01574@2157|Archaea,2XWTK@28890|Euryarchaeota,3F2JS@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site	rrp42	GO:0000177,GO:0000178,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0017091,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354	-	ko:K12589	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
SX3_k127_3049864_7	342949.PNA2_0520	3.5e-20	95.0	COG1997@1|root,arCOG04208@2157|Archaea,2XYWD@28890|Euryarchaeota,244K8@183968|Thermococci	183968|Thermococci	J	binds to the 23S rRNA	rpl37ae	-	-	ko:K02921	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37ae
SX3_k127_3049864_10	1054217.TALC_00324	1.776e-10	68.0	COG1996@1|root,arCOG04341@2157|Archaea,2Y5VN@28890|Euryarchaeota	28890|Euryarchaeota	K	DNA directed RNA polymerase, 7 kDa subunit	-	-	2.7.7.6	ko:K03059	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	DNA_RNApol_7kD
SX3_k127_3049864_11	673860.AciM339_1451	2.281e-05	51.0	COG2892@1|root,arCOG04414@2157|Archaea,2Y77T@28890|Euryarchaeota,3F3IZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Transcription factor Pcc1	-	-	-	ko:K09741	-	-	-	-	ko00000,ko03016	-	-	-	Pcc1
SX3_k127_3049864_8	1236689.MMALV_02930	1.416e-18	94.0	COG1382@1|root,arCOG01342@2157|Archaea,2XX88@28890|Euryarchaeota,3F2W4@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006457,GO:0006996,GO:0007010,GO:0008150,GO:0009987,GO:0016043,GO:0016272,GO:0022607,GO:0032991,GO:0034622,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0051087,GO:0051131,GO:0065003,GO:0071840	-	ko:K04798	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin_2
SX3_k127_3049864_9	391623.TERMP_00173	2.791e-13	80.0	COG0618@1|root,arCOG01565@2157|Archaea,2XWQV@28890|Euryarchaeota,2433D@183968|Thermococci	183968|Thermococci	S	DHH family	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
SX3_k127_311118_3	1454007.JAUG01000160_gene988	0.0007821	53.0	COG4166@1|root,COG5295@1|root,COG4166@2|Bacteria,COG5295@2|Bacteria,4NF6Q@976|Bacteroidetes,1IPUC@117747|Sphingobacteriia	976|Bacteroidetes	EUW	candidate b-glycosidase, glycoside hydrolase family 8 protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_3,M60-like_N,NosD,Peptidase_M60
SX3_k127_311118_2	309807.SRU_0546	1.74e-25	119.0	COG0506@1|root,COG0506@2|Bacteria,4NKZB@976|Bacteroidetes,1FJ33@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Proline dehydrogenase	-	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
SX3_k127_311118_0	1107311.Q767_01620	2.323e-89	330.0	COG3291@1|root,COG3386@1|root,COG5306@1|root,COG3291@2|Bacteria,COG3386@2|Bacteria,COG5306@2|Bacteria,4PM1B@976|Bacteroidetes	976|Bacteroidetes	G	SPTR Cell surface protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_311118_1	1386089.N865_05350	3.248e-88	327.0	COG4733@1|root,COG4733@2|Bacteria,2I7XV@201174|Actinobacteria,4FK2V@85021|Intrasporangiaceae	201174|Actinobacteria	M	Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	fn3
SX3_k127_3118036_6	304371.MCP_1854	1.638e-66	241.0	COG2309@1|root,arCOG01890@2157|Archaea,2XU28@28890|Euryarchaeota	28890|Euryarchaeota	E	Leucyl aminopeptidase (Aminopeptidase t)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M29
SX3_k127_3118036_9	439481.Aboo_1450	5.041e-55	200.0	COG0602@1|root,arCOG02173@2157|Archaea,2XUSP@28890|Euryarchaeota,3F2KS@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_12,Fer4_14,Radical_SAM
SX3_k127_3118036_17	1121129.KB903359_gene1787	9.491e-09	58.0	COG0603@1|root,COG0603@2|Bacteria,4NGCY@976|Bacteroidetes,2FM6W@200643|Bacteroidia,231WZ@171551|Porphyromonadaceae	976|Bacteroidetes	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
SX3_k127_3118036_4	404589.Anae109_3919	4.378e-67	234.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,42MKZ@68525|delta/epsilon subdivisions,2WING@28221|Deltaproteobacteria,2Z04D@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	iAF987.Gmet_3075	QueC
SX3_k127_3118036_10	192952.MM_1365	3.891e-43	172.0	COG0611@1|root,arCOG00638@2157|Archaea,2XSUK@28890|Euryarchaeota,2N9G5@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
SX3_k127_3118036_16	59374.Fisuc_2123	1.13e-11	68.0	COG2768@1|root,COG2768@2|Bacteria	2|Bacteria	-	-	-	-	1.2.7.3	ko:K00176,ko:K07138	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4
SX3_k127_3118036_3	926569.ANT_15400	6.409e-71	251.0	COG0667@1|root,COG0667@2|Bacteria,2G6QZ@200795|Chloroflexi	200795|Chloroflexi	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SX3_k127_3118036_14	595460.RRSWK_06974	9.793e-30	140.0	COG1404@1|root,COG3291@1|root,COG5337@1|root,COG5549@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,COG5337@2|Bacteria,COG5549@2|Bacteria,2IYR8@203682|Planctomycetes	203682|Planctomycetes	M	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CotH
SX3_k127_3118036_5	742766.HMPREF9455_03868	1.05e-66	263.0	COG3386@1|root,COG3386@2|Bacteria,4NF4A@976|Bacteroidetes,2FSDK@200643|Bacteroidia,231RJ@171551|Porphyromonadaceae	976|Bacteroidetes	G	Arylesterase	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pectate_lyase_3,SGL
SX3_k127_3118036_11	177437.HRM2_45380	4.632e-41	178.0	COG1262@1|root,COG1262@2|Bacteria,1R6GS@1224|Proteobacteria,42R3Z@68525|delta/epsilon subdivisions,2WN4D@28221|Deltaproteobacteria,2MJKG@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1566)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1566
SX3_k127_3118036_8	1336803.PHEL49_0498	3.107e-58	235.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	1.8.1.9	ko:K00384,ko:K03671	ko00450,ko04621,ko05418,map00450,map04621,map05418	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110	-	-	-	AhpC-TSA,Arylsulfotrans,Pyr_redox_2,Thioredoxin,Thioredoxin_3
SX3_k127_3118036_7	1380600.AUYN01000001_gene2864	2.361e-58	235.0	COG1520@1|root,COG1520@2|Bacteria,4NHPR@976|Bacteroidetes,1HXXS@117743|Flavobacteriia	976|Bacteroidetes	G	Arylsulfotransferase (ASST)	-	-	-	-	-	-	-	-	-	-	-	-	Arylsulfotrans
SX3_k127_3118036_1	456442.Mboo_0011	2.713e-82	286.0	COG0580@1|root,arCOG04431@2157|Archaea,2XT1N@28890|Euryarchaeota,2N9IJ@224756|Methanomicrobia	224756|Methanomicrobia	G	TIGRFAM MIP family channel	aqpM	-	-	ko:K02440,ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8,1.A.8.1,1.A.8.2	-	-	MIP
SX3_k127_3118036_19	658659.HMPREF0983_03058	2.811e-07	61.0	COG1246@1|root,COG1246@2|Bacteria,1TRN6@1239|Firmicutes	1239|Firmicutes	E	YoaP-like	yoaP	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,YoaP
SX3_k127_3118036_0	304371.MCP_2982	4.475e-144	462.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,2N980@224756|Methanomicrobia	224756|Methanomicrobia	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	-	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Rad51
SX3_k127_3118036_2	1094980.Mpsy_0983	1.886e-76	292.0	COG1404@1|root,arCOG02538@1|root,arCOG03439@1|root,arCOG00702@2157|Archaea,arCOG02538@2157|Archaea,arCOG03439@2157|Archaea,2XTGN@28890|Euryarchaeota,2N9WH@224756|Methanomicrobia	224756|Methanomicrobia	O	Subtilase family	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Calx-beta,Inhibitor_I9,Peptidase_S8
SX3_k127_3118036_12	378806.STAUR_6990	2.018e-40	174.0	COG4412@1|root,COG4412@2|Bacteria,1R3SG@1224|Proteobacteria,42SZZ@68525|delta/epsilon subdivisions,2WPD0@28221|Deltaproteobacteria,2YUKS@29|Myxococcales	28221|Deltaproteobacteria	E	Fungalysin metallopeptidase (M36)	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M36,REJ
SX3_k127_3118036_18	324602.Caur_0649	1.39e-07	66.0	COG1404@1|root,COG4447@1|root,COG1404@2|Bacteria,COG4447@2|Bacteria,2G8UU@200795|Chloroflexi,3759F@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4,Kelch_5,Peptidase_S8
SX3_k127_3118036_13	1041930.Mtc_1230	1.26e-38	147.0	COG1786@1|root,arCOG04279@2157|Archaea,2XYXJ@28890|Euryarchaeota,2N9R7@224756|Methanomicrobia	224756|Methanomicrobia	C	Belongs to the UPF0107 family	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
SX3_k127_3118036_15	408672.NBCG_00994	2.029e-21	102.0	COG0560@1|root,COG0560@2|Bacteria,2GJW9@201174|Actinobacteria,4DNKX@85009|Propionibacteriales	201174|Actinobacteria	E	haloacid dehalogenase-like hydrolase	serB1	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	HAD
SX3_k127_3130149_1	525904.Tter_2775	6.752e-16	92.0	COG3420@1|root,COG3420@2|Bacteria,2NRSC@2323|unclassified Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	-	ko:K12287	-	-	-	-	ko00000,ko02044	-	-	-	Beta_helix,DUF3747,Laminin_G_3,NosD,PQQ_3
SX3_k127_3130149_0	1121403.AUCV01000031_gene2838	5.868e-35	154.0	COG1361@1|root,COG3540@1|root,COG4733@1|root,COG1361@2|Bacteria,COG3540@2|Bacteria,COG4733@2|Bacteria,1QVSF@1224|Proteobacteria	1224|Proteobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,OmpA_membrane
SX3_k127_3146659_0	269797.Mbar_A0288	1.429e-175	557.0	COG1759@1|root,arCOG04346@2157|Archaea,2XUFR@28890|Euryarchaeota,2N9HE@224756|Methanomicrobia	224756|Methanomicrobia	F	Protein of unknown function (DUF1246)	-	-	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
SX3_k127_3146659_1	926567.TheveDRAFT_1175	4.998e-87	300.0	COG0484@1|root,COG0484@2|Bacteria,3TAAF@508458|Synergistetes	508458|Synergistetes	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
SX3_k127_3146659_3	243365.CV_2484	4.899e-15	86.0	COG2311@1|root,COG2311@2|Bacteria,1MWBP@1224|Proteobacteria,2VQY9@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF418)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624,DUF418
SX3_k127_3146659_2	1337936.IJ00_26045	3.696e-19	91.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria,1HIQE@1161|Nostocales	1117|Cyanobacteria	K	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
SX3_k127_3238249_3	42256.RradSPS_0059	4.033e-05	54.0	COG2885@1|root,COG2931@1|root,COG4254@1|root,COG2885@2|Bacteria,COG2931@2|Bacteria,COG4254@2|Bacteria,2HENQ@201174|Actinobacteria,4CQR9@84995|Rubrobacteria	84995|Rubrobacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2
SX3_k127_3238249_1	640513.Entas_2043	8.738e-13	83.0	COG0457@1|root,COG2373@1|root,COG2911@1|root,COG2931@1|root,COG3291@1|root,COG0457@2|Bacteria,COG2373@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3291@2|Bacteria,1MU7T@1224|Proteobacteria,1RMZW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	von willebrand factor, type A	lapA	-	-	ko:K12549	-	-	-	-	ko00000	-	-	-	Big_3_2,Cadherin_3,Calx-beta,HemolysinCabind,VCBS,VWA,VWA_2
SX3_k127_3238249_2	1297742.A176_02032	1.208e-08	69.0	COG0402@1|root,COG1506@1|root,COG2885@1|root,COG0402@2|Bacteria,COG1506@2|Bacteria,COG2885@2|Bacteria,1QX7B@1224|Proteobacteria,431GN@68525|delta/epsilon subdivisions,2WWHZ@28221|Deltaproteobacteria,2YWHU@29|Myxococcales	28221|Deltaproteobacteria	E	Domain of unknown function (DUF4215)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4215
SX3_k127_3238249_4	554065.XP_005847740.1	0.0004496	55.0	2BFIX@1|root,2S176@2759|Eukaryota,37ZU3@33090|Viridiplantae,34KI5@3041|Chlorophyta	3041|Chlorophyta	S	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3238249_0	452637.Oter_3066	1.277e-21	113.0	COG2911@1|root,COG3209@1|root,COG2911@2|Bacteria,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	DctA-YdbH
SX3_k127_3250504_2	1120954.ATXE01000003_gene303	1.153e-39	163.0	COG1409@1|root,COG3291@1|root,COG1409@2|Bacteria,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4DP00@85009|Propionibacteriales	201174|Actinobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PKD
SX3_k127_3250504_3	1379698.RBG1_1C00001G0461	5.016e-21	100.0	COG2143@1|root,COG2143@2|Bacteria	2|Bacteria	O	COG2143 Thioredoxin-related protein	-	-	-	-	-	-	-	-	-	-	-	-	Thioredox_DsbH,Thioredoxin_2,Thioredoxin_7
SX3_k127_3250504_5	316067.Geob_0814	6.623e-06	59.0	COG1361@1|root,COG1520@1|root,COG1657@1|root,COG4257@1|root,COG4733@1|root,COG1361@2|Bacteria,COG1520@2|Bacteria,COG1657@2|Bacteria,COG4257@2|Bacteria,COG4733@2|Bacteria,1QYWJ@1224|Proteobacteria,43CDC@68525|delta/epsilon subdivisions,2X7P6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
SX3_k127_3250504_0	634498.mru_2077	1.462e-255	823.0	COG0495@1|root,arCOG00809@2157|Archaea,2XU7M@28890|Euryarchaeota,23NV4@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
SX3_k127_3250504_1	261292.Nit79A3_0968	7.041e-63	233.0	COG0477@1|root,COG2814@2|Bacteria,1QV32@1224|Proteobacteria,2WA0K@28216|Betaproteobacteria,3746I@32003|Nitrosomonadales	28216|Betaproteobacteria	EGP	PFAM Major facilitator superfamily MFS-1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX3_k127_3250504_4	304371.MCP_2061	1.746e-10	74.0	COG0457@1|root,arCOG02497@1|root,arCOG02497@2157|Archaea,arCOG03032@2157|Archaea	2157|Archaea	T	PFAM TPR repeat-containing protein	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	Beta_helix,TPR_16,TPR_19
SX3_k127_3250504_6	9365.XP_007534858.1	0.0005303	44.0	KOG2385@1|root,KOG2385@2759|Eukaryota,38DI9@33154|Opisthokonta,3BDEH@33208|Metazoa,3CT7E@33213|Bilateria,4826Z@7711|Chordata,4920R@7742|Vertebrata,3J493@40674|Mammalia	33208|Metazoa	S	Protein of unknown function (DUF726)	TMCO4	-	-	-	-	-	-	-	-	-	-	-	DUF726
SX3_k127_3254042_12	481448.Minf_1726	1.34e-46	179.0	COG2220@1|root,COG2220@2|Bacteria,46UIR@74201|Verrucomicrobia,37GGK@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
SX3_k127_3254042_3	1329516.JPST01000021_gene2493	3.497e-125	422.0	COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,4H9VY@91061|Bacilli,27AXN@186824|Thermoactinomycetaceae	91061|Bacilli	G	Pyruvate kinase, alpha/beta domain	pyk	GO:0001871,GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006116,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0019693,GO:0019752,GO:0030246,GO:0030247,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:2001065	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
SX3_k127_3254042_4	925409.KI911562_gene2239	1.463e-113	375.0	COG0205@1|root,COG0205@2|Bacteria,4NF8F@976|Bacteroidetes,1IPUF@117747|Sphingobacteriia	976|Bacteroidetes	G	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
SX3_k127_3254042_13	589924.Ferp_2553	6.694e-23	104.0	COG1545@1|root,arCOG01287@2157|Archaea,2Y2YT@28890|Euryarchaeota,246S2@183980|Archaeoglobi	183980|Archaeoglobi	S	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
SX3_k127_3254042_10	1379698.RBG1_1C00001G1463	4.833e-53	196.0	COG1545@1|root,COG1545@2|Bacteria	2|Bacteria	I	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
SX3_k127_3254042_1	1379698.RBG1_1C00001G1464	2.049e-190	606.0	COG0183@1|root,COG0183@2|Bacteria,2NP9T@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the thiolase family	ltp4	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C
SX3_k127_3254042_5	1379698.RBG1_1C00001G1465	3.324e-93	319.0	COG0183@1|root,COG0183@2|Bacteria,2NP9T@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the thiolase family	ltp4	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C
SX3_k127_3254042_0	1379698.RBG1_1C00001G0509	2.153e-202	657.0	COG1042@1|root,COG1042@2|Bacteria,2NNW5@2323|unclassified Bacteria	2|Bacteria	C	synthetase (ADP forming), alpha	-	-	6.2.1.13	ko:K01905,ko:K09181,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
SX3_k127_3254042_7	1054217.TALC_01128	1.893e-75	265.0	COG2520@1|root,arCOG00033@2157|Archaea,2XTSI@28890|Euryarchaeota,241R8@183967|Thermoplasmata	183967|Thermoplasmata	J	Met-10+ like-protein	-	-	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
SX3_k127_3254042_6	529709.PYCH_07540	8.51e-81	277.0	COG1798@1|root,arCOG04161@2157|Archaea,2XV63@28890|Euryarchaeota,242XM@183968|Thermococci	183968|Thermococci	J	S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis	dphB	GO:0003674,GO:0003824,GO:0004164,GO:0006417,GO:0006448,GO:0006464,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009056,GO:0009058,GO:0009109,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0010608,GO:0016740,GO:0016741,GO:0017144,GO:0017182,GO:0017183,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0031323,GO:0031326,GO:0032259,GO:0032268,GO:0034248,GO:0036211,GO:0042737,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044273,GO:0046500,GO:0050789,GO:0050794,GO:0050843,GO:0051171,GO:0051186,GO:0051187,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1900247,GO:1901564,GO:1901575,GO:2000112,GO:2000765	2.1.1.98	ko:K20215	-	-	R04481,R08468,R08469,R10306	RC00003,RC00190,RC01155,RC02136,RC02308	ko00000,ko01000	-	-	-	TP_methylase
SX3_k127_3254042_2	767817.Desgi_1433	8.553e-165	534.0	COG0365@1|root,COG0365@2|Bacteria,1UMN9@1239|Firmicutes,25GME@186801|Clostridia	186801|Clostridia	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.32	ko:K08295	ko00627,ko01120,map00627,map01120	-	R00982	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
SX3_k127_3254042_14	643648.Slip_2185	2.085e-20	98.0	COG1764@1|root,COG1764@2|Bacteria,1VYMJ@1239|Firmicutes,2538T@186801|Clostridia	186801|Clostridia	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
SX3_k127_3254042_8	903814.ELI_1211	1.369e-69	246.0	COG2998@1|root,COG2998@2|Bacteria,1TQA9@1239|Firmicutes,249EZ@186801|Clostridia,25YEQ@186806|Eubacteriaceae	186801|Clostridia	H	PBP superfamily domain	tupA	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
SX3_k127_3254042_9	1089553.Tph_c27340	3.148e-54	197.0	COG4662@1|root,COG4662@2|Bacteria,1TRK7@1239|Firmicutes,249VG@186801|Clostridia,42G0B@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	tupB	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
SX3_k127_3254042_11	593750.Metfor_0675	7.02e-49	195.0	COG3585@1|root,COG3839@1|root,arCOG00175@2157|Archaea,arCOG00228@2157|Archaea,2Y7NF@28890|Euryarchaeota,2N9QM@224756|Methanomicrobia	224756|Methanomicrobia	E	ATPases associated with a variety of cellular activities	-	-	3.6.3.55	ko:K06857	ko02010,map02010	M00186	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	ABC_tran,TOBE
SX3_k127_3260159_5	374847.Kcr_0638	6.622e-16	92.0	arCOG02559@1|root,arCOG02559@2157|Archaea	2157|Archaea	P	by modhmm	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
SX3_k127_3260159_6	593117.TGAM_0375	1.318e-13	84.0	arCOG07813@1|root,arCOG07813@2157|Archaea	2157|Archaea	C	LamG domain protein jellyroll fold domain protein	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Laminin_G_3
SX3_k127_3260159_0	868131.MSWAN_1773	8.101e-96	326.0	COG0436@1|root,arCOG04897@2157|Archaea,2XURI@28890|Euryarchaeota,23NXC@183925|Methanobacteria	183925|Methanobacteria	E	PFAM Aminotransferase, class I	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
SX3_k127_3260159_4	222534.KB893670_gene3882	3.578e-41	177.0	COG3507@1|root,COG3507@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Glyco_hyd_101C,Glyco_hydro_101,Glyco_hydro_43,NPCBM,NPCBM_assoc,RicinB_lectin_2
SX3_k127_3260159_3	1209072.ALBT01000012_gene3407	1.111e-66	233.0	COG4832@1|root,COG4832@2|Bacteria,1RBGY@1224|Proteobacteria,1SAGB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	GyrI-like small molecule binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
SX3_k127_3260159_1	1173024.KI912149_gene6263	3.5e-86	298.0	COG0454@1|root,COG1846@1|root,COG0456@2|Bacteria,COG1846@2|Bacteria,1GKR9@1117|Cyanobacteria,1JMKR@1189|Stigonemataceae	1117|Cyanobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SX3_k127_3260159_2	871963.Desdi_0372	9.772e-69	243.0	COG0348@1|root,COG0348@2|Bacteria,1UVRB@1239|Firmicutes,25I6A@186801|Clostridia,266AF@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_9
SX3_k127_3271932_9	324602.Caur_0392	0.0009112	51.0	COG1361@1|root,COG1470@1|root,COG1361@2|Bacteria,COG1470@2|Bacteria,2GA7Y@200795|Chloroflexi,376PQ@32061|Chloroflexia	32061|Chloroflexia	M	SMART Parallel beta-helix repeat	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NPCBM_assoc
SX3_k127_3271932_8	1347087.CBYO010000022_gene3239	4.952e-09	70.0	COG1404@1|root,COG4412@1|root,COG1404@2|Bacteria,COG4412@2|Bacteria,1TPUY@1239|Firmicutes,4HBDE@91061|Bacilli	91061|Bacilli	O	COG1404 Subtilisin-like serine proteases	bpr	GO:0005575,GO:0005576	-	ko:K13276	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Inhibitor_I9,Peptidase_M6,Peptidase_S8
SX3_k127_3271932_6	981383.AEWH01000063_gene1899	1.407e-13	85.0	COG1404@1|root,COG4412@1|root,COG1404@2|Bacteria,COG4412@2|Bacteria,1TPUY@1239|Firmicutes,4HBDE@91061|Bacilli	91061|Bacilli	O	COG1404 Subtilisin-like serine proteases	bpr	GO:0005575,GO:0005576	-	ko:K13276	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Inhibitor_I9,Peptidase_M6,Peptidase_S8
SX3_k127_3271932_3	673860.AciM339_0364	3.485e-61	226.0	COG0388@1|root,arCOG00062@2157|Archaea,2XT6R@28890|Euryarchaeota,3F2PP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Carbon-nitrogen hydrolase	-	-	3.5.1.100	ko:K18540	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
SX3_k127_3271932_2	673860.AciM339_0533	8.205e-98	335.0	COG1746@1|root,arCOG04249@2157|Archaea,2XT5J@28890|Euryarchaeota,3F2HM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate	cca	-	2.7.7.72	ko:K07558	-	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko01000,ko03016	-	-	-	NTP_transf_2,tRNA_NucTransf2
SX3_k127_3271932_4	453591.Igni_0850	8.758e-37	155.0	COG1514@1|root,arCOG01736@2157|Archaea,2XQM6@28889|Crenarchaeota	28889|Crenarchaeota	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
SX3_k127_3271932_7	994479.GL877878_gene894	6.836e-12	78.0	COG2339@1|root,COG2339@2|Bacteria,2GKR5@201174|Actinobacteria,4DZMH@85010|Pseudonocardiales	201174|Actinobacteria	NU	Protease prsW family	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
SX3_k127_3271932_5	673860.AciM339_0498	2.438e-26	112.0	COG4738@1|root,arCOG04377@2157|Archaea,2XZEC@28890|Euryarchaeota,3F3DI@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3271932_1	673860.AciM339_1241	6.226e-140	463.0	COG1031@1|root,arCOG01359@2157|Archaea,2XSVQ@28890|Euryarchaeota,3F2GV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Helix-hairpin-helix DNA-binding motif class 1	-	-	-	-	-	-	-	-	-	-	-	-	HHH,HHH_3,Radical_SAM
SX3_k127_3271932_0	1041930.Mtc_1154	1.519e-184	588.0	COG0443@1|root,arCOG03060@2157|Archaea,2XT86@28890|Euryarchaeota,2N91T@224756|Methanomicrobia	224756|Methanomicrobia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
SX3_k127_3279108_7	706587.Desti_0173	1.236e-35	139.0	COG0509@1|root,COG0509@2|Bacteria,1NYE8@1224|Proteobacteria,430NZ@68525|delta/epsilon subdivisions,2WW4N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Glycine cleavage system H protein	-	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
SX3_k127_3279108_5	644282.Deba_2986	3.633e-59	218.0	COG0095@1|root,COG0095@2|Bacteria,1RDZE@1224|Proteobacteria	1224|Proteobacteria	H	PFAM biotin lipoate A B protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
SX3_k127_3279108_13	644282.Deba_3040	2.231e-16	85.0	COG0509@1|root,COG0509@2|Bacteria,1NYE8@1224|Proteobacteria,430NZ@68525|delta/epsilon subdivisions,2WW4N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Glycine cleavage system H protein	-	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
SX3_k127_3279108_1	264732.Moth_0445	2.323e-123	404.0	COG2516@1|root,COG2516@2|Bacteria,1TQF6@1239|Firmicutes,24AAS@186801|Clostridia,42GXU@68295|Thermoanaerobacterales	186801|Clostridia	S	Elongator protein 3, MiaB family, Radical SAM	-	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
SX3_k127_3279108_2	316274.Haur_2819	1.055e-105	387.0	COG3266@1|root,COG3266@2|Bacteria,2G7UN@200795|Chloroflexi,377BD@32061|Chloroflexia	32061|Chloroflexia	K	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3279108_0	246194.CHY_2199	7.038e-135	440.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,42FGX@68295|Thermoanaerobacterales	186801|Clostridia	H	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
SX3_k127_3279108_14	1047013.AQSP01000144_gene918	1.155e-15	79.0	COG0425@1|root,COG0425@2|Bacteria	2|Bacteria	O	sulfur carrier activity	tusA	GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0019725,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042592,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048878,GO:0051186,GO:0051188,GO:0051189,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0090407,GO:0097163,GO:0140104,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.14,2.8.1.7	ko:K00549,ko:K04085,ko:K04487,ko:K08363	ko00270,ko00450,ko00730,ko01100,ko01110,ko01230,ko04122,map00270,map00450,map00730,map01100,map01110,map01230,map04122	M00017	R04405,R07460,R09365,R11528,R11529	RC00035,RC00113,RC01241,RC01789,RC02313	ko00000,ko00001,ko00002,ko01000,ko02000,ko02048,ko03016,ko03029	1.A.72.1	-	-	DUF2249,Rhodanese,TusA
SX3_k127_3279108_16	573063.Metin_0368	5.295e-12	67.0	COG1146@1|root,arCOG00959@2157|Archaea,2Y10S@28890|Euryarchaeota,23R86@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Fer4_6,Fer4_7
SX3_k127_3279108_9	456442.Mboo_0235	1.114e-24	104.0	arCOG12677@1|root,arCOG12677@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3279108_17	1384057.CD33_10005	1.454e-06	55.0	COG0695@1|root,COG0695@2|Bacteria,1VHHY@1239|Firmicutes,4HP37@91061|Bacilli,3IYRR@400634|Lysinibacillus	91061|Bacilli	O	Thiol-disulfide isomerase	-	-	-	-	-	-	-	-	-	-	-	-	DUF836
SX3_k127_3279108_15	1535422.ND16A_1818	1.27e-14	89.0	COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,1MU3S@1224|Proteobacteria,1RWN2@1236|Gammaproteobacteria,2Q85J@267889|Colwelliaceae	1236|Gammaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
SX3_k127_3279108_18	1121935.AQXX01000098_gene1662	4.674e-05	57.0	COG3386@1|root,COG3391@1|root,COG4625@1|root,COG4733@1|root,COG3386@2|Bacteria,COG3391@2|Bacteria,COG4625@2|Bacteria,COG4733@2|Bacteria,1R2J4@1224|Proteobacteria,1T5QW@1236|Gammaproteobacteria,1XQGX@135619|Oceanospirillales	135619|Oceanospirillales	G	Calx-beta domain	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta
SX3_k127_3279108_6	693661.Arcve_0149	7.685e-37	146.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,246Q2@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator, ArsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
SX3_k127_3279108_3	316274.Haur_2819	3.131e-82	312.0	COG3266@1|root,COG3266@2|Bacteria,2G7UN@200795|Chloroflexi,377BD@32061|Chloroflexia	32061|Chloroflexia	K	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3279108_10	589924.Ferp_0933	2.393e-23	108.0	COG0640@1|root,arCOG01683@2157|Archaea,2Y0SK@28890|Euryarchaeota,2476X@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
SX3_k127_3279108_12	765913.ThidrDRAFT_1810	2.311e-17	99.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,1RZ6G@1236|Gammaproteobacteria,1X1H2@135613|Chromatiales	135613|Chromatiales	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
SX3_k127_3279108_4	1293048.CBMB010000010_gene3725	3.701e-76	293.0	COG1520@1|root,arCOG02482@2157|Archaea,arCOG02492@2157|Archaea,arCOG02556@2157|Archaea,2XZQY@28890|Euryarchaeota,23X43@183963|Halobacteria	183963|Halobacteria	S	Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
SX3_k127_3279108_11	589924.Ferp_1599	2.399e-21	99.0	COG0694@1|root,arCOG03028@2157|Archaea,2XYXW@28890|Euryarchaeota,246FA@183980|Archaeoglobi	183980|Archaeoglobi	O	Nitrogen-fixing NifU domain protein	-	-	-	-	-	-	-	-	-	-	-	-	NifU
SX3_k127_3279108_8	673860.AciM339_0648	9.827e-35	134.0	COG1245@1|root,arCOG00187@2157|Archaea,2XSZE@28890|Euryarchaeota,3F2G2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	metal-binding domain in RNase L inhibitor, RLI	rli	GO:0000166,GO:0003674,GO:0005488,GO:0005506,GO:0005524,GO:0006412,GO:0006413,GO:0006415,GO:0006518,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0017076,GO:0019538,GO:0022411,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032984,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0046872,GO:0046914,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,RLI
SX3_k127_3280597_3	673860.AciM339_0491	7.943e-18	86.0	arCOG13524@1|root,arCOG13524@2157|Archaea,2Y754@28890|Euryarchaeota,3F3EV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3280597_4	439481.Aboo_1066	3.175e-09	70.0	arCOG03439@1|root,arCOG03439@2157|Archaea	2157|Archaea	L	PFAM periplasmic copper-binding	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_3,NosD
SX3_k127_3280597_1	1236689.MMALV_07190	6.298e-54	200.0	arCOG04973@1|root,arCOG04973@2157|Archaea,2XX73@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3280597_2	304371.MCP_2676	2.687e-45	176.0	COG1829@1|root,arCOG04263@2157|Archaea,2XST6@28890|Euryarchaeota,2N9J3@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM GHMP kinase	-	-	2.7.1.169	ko:K06982	ko00770,ko01100,map00770,map01100	-	R09378	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A3255	GHMP_kinases_N
SX3_k127_3280597_0	269797.Mbar_A3256	2.936e-94	322.0	COG0452@1|root,arCOG01704@2157|Archaea,2XTZK@28890|Euryarchaeota,2N9EA@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	dfp	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
SX3_k127_3288688_18	1521187.JPIM01000167_gene1704	5.733e-21	108.0	COG0457@1|root,COG1404@1|root,COG0457@2|Bacteria,COG1404@2|Bacteria,2G8UU@200795|Chloroflexi,3759F@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4,Kelch_5,Peptidase_S8
SX3_k127_3288688_24	1171373.PACID_07910	8.185e-11	76.0	COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4DP00@85009|Propionibacteriales	201174|Actinobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	wcoG	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PKD
SX3_k127_3288688_0	673860.AciM339_0861	6.901e-138	445.0	COG0470@1|root,arCOG00469@2157|Archaea,2XTC8@28890|Euryarchaeota,3F2I9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcS	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005663,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901576	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,DNA_pol3_delta2,HTH_3,Intein_splicing,LAGLIDADG_3,Rad17,Rep_fac_C,RuvB_N
SX3_k127_3288688_27	1123228.AUIH01000092_gene552	2.975e-08	69.0	COG3291@1|root,COG5184@1|root,COG3291@2|Bacteria,COG5184@2|Bacteria,1RA9Y@1224|Proteobacteria,1T5TQ@1236|Gammaproteobacteria,1XNA1@135619|Oceanospirillales	135619|Oceanospirillales	G	regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3288688_14	7739.XP_002600439.1	2.176e-31	145.0	29BDQ@1|root,2RIGR@2759|Eukaryota,39XEG@33154|Opisthokonta,3BY63@33208|Metazoa,3DE57@33213|Bilateria	33208|Metazoa	S	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF642
SX3_k127_3288688_34	880071.Fleli_2410	0.0001942	56.0	COG5492@1|root,COG5492@2|Bacteria,4PAER@976|Bacteroidetes,47TE8@768503|Cytophagia	976|Bacteroidetes	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3288688_25	7668.SPU_017559-tr	1.183e-10	72.0	KOG3780@1|root,KOG3780@2759|Eukaryota,38D4U@33154|Opisthokonta,3BJG5@33208|Metazoa,3CY15@33213|Bilateria	33208|Metazoa	S	negative regulation of heat generation	-	GO:0003674,GO:0005488,GO:0005515,GO:0019899,GO:0019902,GO:0019903,GO:0030346	-	-	-	-	-	-	-	-	-	-	Arrestin_C,Arrestin_N
SX3_k127_3288688_33	292459.STH2381	3.176e-05	53.0	2BYGJ@1|root,33C7C@2|Bacteria,1VK9F@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3288688_13	1054217.TALC_01268	9.752e-38	157.0	COG0727@1|root,arCOG02579@2157|Archaea,2Y0ZN@28890|Euryarchaeota	28890|Euryarchaeota	S	Putative zinc- or iron-chelating domain	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
SX3_k127_3288688_22	880073.Calab_0526	8.256e-16	93.0	COG1404@1|root,COG3291@1|root,COG3386@1|root,COG5276@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,COG3386@2|Bacteria,COG5276@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.1.1.17,3.2.1.4	ko:K01053,ko:K01179,ko:K07214,ko:K12287	ko00030,ko00053,ko00500,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00500,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751,R06200,R11307,R11308	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko02044,ko04147	-	GH5,GH9	-	Big_5,DUF285,Esterase,He_PIG,SGL
SX3_k127_3288688_6	456442.Mboo_1987	2.715e-65	230.0	COG0301@1|root,arCOG00038@2157|Archaea,2XYMB@28890|Euryarchaeota,2NBHY@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	-	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	ThiI
SX3_k127_3288688_17	59374.Fisuc_0063	2.325e-23	117.0	COG2911@1|root,COG4254@1|root,COG2911@2|Bacteria,COG4254@2|Bacteria	2|Bacteria	UW	PFAM FecR protein	lgt	-	-	ko:K09800,ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001,ko02000	-	-	-	FecR
SX3_k127_3288688_20	368407.Memar_0091	3.846e-16	94.0	COG3398@1|root,arCOG02611@2157|Archaea	2157|Archaea	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
SX3_k127_3288688_23	252305.OB2597_03943	5.989e-12	80.0	COG2911@1|root,COG2931@1|root,COG4932@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,2PF86@252301|Oceanicola	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,HCBP_related,He_PIG,HemolysinCabind
SX3_k127_3288688_12	1347368.HG964403_gene4490	3.423e-40	173.0	COG4632@1|root,COG5492@1|root,COG4632@2|Bacteria,COG5492@2|Bacteria,1V706@1239|Firmicutes,4IQJJ@91061|Bacilli	91061|Bacilli	N	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
SX3_k127_3288688_35	1198449.ACAM_0349	0.0002323	52.0	COG0517@1|root,COG1522@1|root,arCOG00606@2157|Archaea,arCOG01117@2157|Archaea,2XRRU@28889|Crenarchaeota	28889|Crenarchaeota	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,CBS
SX3_k127_3288688_15	273116.14325323	1.329e-23	108.0	COG1581@1|root,arCOG01753@2157|Archaea,2XZH4@28890|Euryarchaeota,242BE@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	albA	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
SX3_k127_3288688_7	445975.COLSTE_00895	5.023e-65	236.0	COG0191@1|root,COG0191@2|Bacteria,2H640@201174|Actinobacteria,4CXJM@84998|Coriobacteriia	84998|Coriobacteriia	H	Fructose-bisphosphate aldolase class-II	-	-	-	-	-	-	-	-	-	-	-	-	F_bP_aldolase
SX3_k127_3288688_16	319224.Sputcn32_3550	2.182e-23	117.0	COG2931@1|root,COG3637@1|root,COG2931@2|Bacteria,COG3637@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,2QA62@267890|Shewanellaceae	1236|Gammaproteobacteria	MQ	Dystroglycan-type cadherin domain protein	-	-	-	ko:K11005	-	-	-	-	ko00000,ko02000,ko02042	1.C.11	-	-	Cadherin_3,Calx-beta,He_PIG,HemolysinCabind,VWA_2
SX3_k127_3288688_29	243231.GSU2073	3.686e-07	63.0	COG3209@1|root,COG3227@1|root,COG3391@1|root,COG3209@2|Bacteria,COG3227@2|Bacteria,COG3391@2|Bacteria,1QW4H@1224|Proteobacteria	1224|Proteobacteria	M	Rhs Family	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Autotransporter,Big_3_2,Big_3_5,DUF4082,DUF4347,He_PIG,PT-HINT,RHS_repeat
SX3_k127_3288688_3	439481.Aboo_0930	1.469e-127	420.0	COG1236@1|root,arCOG00541@2157|Archaea,2XTIU@28890|Euryarchaeota,3F2F9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Beta-Casp domain	epf1	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_2,Lactamase_B_6,RMMBL
SX3_k127_3288688_19	519442.Huta_1990	8.91e-19	101.0	COG1520@1|root,arCOG02482@2157|Archaea,2XUI1@28890|Euryarchaeota,240TC@183963|Halobacteria	183963|Halobacteria	C	COG1520 FOG WD40-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_3
SX3_k127_3288688_32	196367.JNFG01000215_gene810	2.53e-05	57.0	COG1520@1|root,COG4934@1|root,COG1520@2|Bacteria,COG4934@2|Bacteria,1R55X@1224|Proteobacteria,2VR5H@28216|Betaproteobacteria,1K05T@119060|Burkholderiaceae	1224|Proteobacteria	O	peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	ko:K08677	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_S8,Pro-kuma_activ
SX3_k127_3288688_31	550540.Fbal_0429	1.919e-05	58.0	COG3240@1|root,COG3240@2|Bacteria	2|Bacteria	I	lipase activity	estA	GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0016289,GO:0016290,GO:0016787,GO:0016788,GO:0016790,GO:0047617,GO:0052689	3.1.3.8	ko:K01083,ko:K11018,ko:K12686,ko:K15349,ko:K21831	ko00562,ko05132,map00562,map05132	-	R03371	RC00078	ko00000,ko00001,ko01000,ko02000,ko02042,ko02044	1.B.12.8	-	-	Autotransporter,Lipase_GDSL
SX3_k127_3288688_11	272844.PAB1845	7.914e-44	168.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT0T@28890|Euryarchaeota,242X5@183968|Thermococci	183968|Thermococci	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SX3_k127_3288688_2	203119.Cthe_0611	8.717e-128	425.0	COG1236@1|root,COG1236@2|Bacteria,1TQBH@1239|Firmicutes,248QR@186801|Clostridia,3WHA0@541000|Ruminococcaceae	186801|Clostridia	J	Metallo-beta-lactamase domain protein	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
SX3_k127_3288688_10	195522.BD01_0649	4.64e-46	188.0	COG0281@1|root,arCOG01331@2157|Archaea,2XTRZ@28890|Euryarchaeota,242SQ@183968|Thermococci	183968|Thermococci	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
SX3_k127_3288688_30	231434.JQJH01000001_gene1729	3.841e-07	61.0	COG0457@1|root,COG2227@1|root,COG3914@1|root,COG0457@2|Bacteria,COG2227@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2TRVB@28211|Alphaproteobacteria,3NAKJ@45404|Beijerinckiaceae	28211|Alphaproteobacteria	HO	Glycosyl transferase family 41	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,Methyltransf_23,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
SX3_k127_3288688_4	1041930.Mtc_1450	7.429e-88	299.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTTP@28890|Euryarchaeota,2N940@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0021	Epimerase,GDP_Man_Dehyd
SX3_k127_3288688_21	768679.TTX_0727	8.151e-16	87.0	COG0561@1|root,arCOG01213@2157|Archaea,2XQHH@28889|Crenarchaeota	28889|Crenarchaeota	G	Catalyzes the dephosphorylation of 2-phosphoglycolate	-	-	3.1.3.18	ko:K22223	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	Hydrolase_3
SX3_k127_3288688_1	1499967.BAYZ01000136_gene53	1.074e-129	424.0	COG1088@1|root,COG1088@2|Bacteria,2NNRC@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rfbB	GO:0000166,GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008460,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019305,GO:0019438,GO:0030312,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044464,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0048037,GO:0050662,GO:0051287,GO:0055086,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	4.2.1.46,4.2.1.76	ko:K01710,ko:K12450	ko00520,ko00521,ko00523,ko00525,ko01055,ko01130,map00520,map00521,map00523,map00525,map01055,map01130	M00793	R00293,R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3464	GDP_Man_Dehyd
SX3_k127_3288688_26	33035.JPJF01000023_gene3227	1.463e-08	68.0	COG3292@1|root,COG3292@2|Bacteria,1UICX@1239|Firmicutes,24ABD@186801|Clostridia,3Y1BC@572511|Blautia	186801|Clostridia	T	Psort location Extracellular, score	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3
SX3_k127_3288688_36	511051.CSE_15110	0.0003972	54.0	COG4945@1|root,COG4945@2|Bacteria	2|Bacteria	G	C-terminal binding-module, SLH-like, of glucodextranase	-	-	3.2.1.3	ko:K01178	ko00500,ko01100,map00500,map01100	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000	-	GH15	-	Alpha-amylase,Cu_amine_oxidN1,Glucodextran_B,Glucodextran_C,Glucodextran_N,Glyco_hydro_15,Glyco_hydro_49,Glyco_hydro_49N
SX3_k127_3288688_5	760568.Desku_0717	8.184e-72	245.0	COG1898@1|root,COG1898@2|Bacteria,1V4G5@1239|Firmicutes,24IZ8@186801|Clostridia,262MP@186807|Peptococcaceae	186801|Clostridia	M	dTDP-4-dehydrorhamnose 3,5-epimerase	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
SX3_k127_3288688_9	439481.Aboo_0444	2.973e-52	199.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y4UK@28890|Euryarchaeota,3F2ZZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	GvpD gas vesicle protein	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
SX3_k127_3288688_8	439481.Aboo_0444	4.645e-57	207.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y4UK@28890|Euryarchaeota,3F2ZZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	GvpD gas vesicle protein	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
SX3_k127_3291499_1	351160.RRC419	1.882e-30	130.0	COG2178@1|root,arCOG04318@2157|Archaea,2XYD0@28890|Euryarchaeota,2N9Q9@224756|Methanomicrobia	224756|Methanomicrobia	J	RNA-binding protein of the translin family	-	-	-	ko:K07477	-	-	-	-	ko00000	-	-	-	Translin
SX3_k127_3291499_0	1236689.MMALV_01790	8.537e-71	249.0	COG0592@1|root,arCOG00488@2157|Archaea,2XT8B@28890|Euryarchaeota,3F2MA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication	pcn	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006272,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0022616,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043626,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0044796,GO:0046483,GO:0050790,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576	-	ko:K04802	ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166	M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	PCNA_C,PCNA_N
SX3_k127_3291499_2	192952.MM_2441	5.773e-08	61.0	COG3398@1|root,arCOG02611@2157|Archaea,2XV4M@28890|Euryarchaeota,2NB4N@224756|Methanomicrobia	224756|Methanomicrobia	K	Winged helix-turn-helix DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
SX3_k127_3292272_3	357808.RoseRS_1520	5.148e-66	248.0	COG1716@1|root,COG1716@2|Bacteria,2G9KV@200795|Chloroflexi,376M0@32061|Chloroflexia	32061|Chloroflexia	T	PFAM Forkhead-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Peptidase_C11
SX3_k127_3292272_11	1380346.JNIH01000015_gene708	0.0004327	53.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria	201174|Actinobacteria	M	Oxidoreductase molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
SX3_k127_3292272_8	543526.Htur_2904	5.927e-12	78.0	COG1011@1|root,arCOG02291@2157|Archaea,2XUJR@28890|Euryarchaeota,23TB1@183963|Halobacteria	183963|Halobacteria	S	hydrolase (HAD superfamily)	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
SX3_k127_3292272_1	673860.AciM339_1573	6.372e-124	408.0	COG0182@1|root,arCOG01123@2157|Archaea,2Y86P@28890|Euryarchaeota,3F36H@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	-	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.23	ko:K03239,ko:K08963	ko00270,ko01100,ko03013,map00270,map01100,map03013	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000,ko03012	-	-	-	IF-2B
SX3_k127_3292272_4	673860.AciM339_1522	1.224e-57	216.0	COG2237@1|root,arCOG04151@2157|Archaea,2XTV5@28890|Euryarchaeota,3F2NQ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Domain of unknown function (DUF373)	-	-	-	ko:K08975	-	-	-	-	ko00000	-	-	-	DUF373
SX3_k127_3292272_5	304371.MCP_2737	5.166e-40	154.0	arCOG05710@1|root,arCOG05710@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3292272_0	351160.RCIX132	7.113e-151	485.0	arCOG01917@1|root,arCOG01917@2157|Archaea,2XYA0@28890|Euryarchaeota	28890|Euryarchaeota	O	SPFH domain-Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DZR,zinc_ribbon_2
SX3_k127_3292272_10	1459636.NTE_00472	2.274e-08	59.0	arCOG08550@1|root,arCOG08550@2157|Archaea	2157|Archaea	T	Putative antitoxin	-	-	-	-	-	-	-	-	-	-	-	-	VAPB_antitox
SX3_k127_3292272_6	1459636.NTE_00268	6.509e-25	108.0	COG1487@1|root,arCOG02219@2157|Archaea	2157|Archaea	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	vapC	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
SX3_k127_3292272_2	1094980.Mpsy_1503	5.106e-95	334.0	COG1122@1|root,arCOG00203@2157|Archaea,2Y7N4@28890|Euryarchaeota	28890|Euryarchaeota	P	part of an ABC transporter complex. Responsible for energy coupling to the transport system	ecfA	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
SX3_k127_3292272_7	269799.Gmet_2440	1.106e-19	98.0	COG0619@1|root,COG0619@2|Bacteria,1R2DN@1224|Proteobacteria,43B6A@68525|delta/epsilon subdivisions,2X6JT@28221|Deltaproteobacteria,43S05@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Cobalt transport protein	nikQ	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
SX3_k127_3292272_9	604354.TSIB_1318	3.703e-09	63.0	COG0310@1|root,arCOG03159@2157|Archaea,2Y4ZC@28890|Euryarchaeota,244HB@183968|Thermococci	183968|Thermococci	P	PDGLE domain	-	-	-	ko:K02009	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18	-	-	-
SX3_k127_3304470_4	386456.JQKN01000002_gene2802	8.701e-28	126.0	COG1371@1|root,arCOG04055@2157|Archaea,2XXRX@28890|Euryarchaeota,23P74@183925|Methanobacteria	183925|Methanobacteria	S	Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently	-	-	-	-	-	-	-	-	-	-	-	-	Archease
SX3_k127_3304470_3	673860.AciM339_1575	9.478e-43	167.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y4JI@28890|Euryarchaeota,3F328@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	DnaB-like helicase C terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
SX3_k127_3304470_0	673860.AciM339_0958	3.925e-180	581.0	COG0008@1|root,arCOG04302@2157|Archaea,2XSYV@28890|Euryarchaeota,3F2HK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
SX3_k127_3304470_6	398512.JQKC01000023_gene3271	1.316e-05	57.0	COG1361@1|root,COG2333@1|root,COG2866@1|root,COG2931@1|root,COG3210@1|root,COG3266@1|root,COG3291@1|root,COG3391@1|root,COG4733@1|root,COG5492@1|root,COG1361@2|Bacteria,COG2333@2|Bacteria,COG2866@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3266@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,COG4733@2|Bacteria,COG5492@2|Bacteria,1TQ2T@1239|Firmicutes,24EP0@186801|Clostridia,3WI1H@541000|Ruminococcaceae	186801|Clostridia	MU	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,PKD,Paired_CXXCH_1,SLH,fn3
SX3_k127_3304470_1	574087.Acear_0953	2.293e-70	244.0	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia,3WBKW@53433|Halanaerobiales	186801|Clostridia	S	Methionine synthase B12-binding module cap domain protein	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
SX3_k127_3304470_2	1499967.BAYZ01000177_gene5729	4.601e-63	237.0	COG0207@1|root,COG0207@2|Bacteria	2|Bacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
SX3_k127_3304470_5	304371.MCP_2061	1.903e-08	66.0	COG0457@1|root,arCOG02497@1|root,arCOG02497@2157|Archaea,arCOG03032@2157|Archaea	2157|Archaea	T	PFAM TPR repeat-containing protein	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	Beta_helix,TPR_16,TPR_19
SX3_k127_330842_3	404589.Anae109_1895	0.000294	53.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,42MD3@68525|delta/epsilon subdivisions,2WJQ0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Thiamine pyrophosphate	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
SX3_k127_330842_0	529709.PYCH_02380	1.654e-116	397.0	COG0674@1|root,arCOG01607@2157|Archaea,2XW4W@28890|Euryarchaeota,2434K@183968|Thermococci	183968|Thermococci	C	ferredoxin oxidoreductase, subunit alpha	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
SX3_k127_330842_2	335543.Sfum_0018	5.052e-18	86.0	COG1146@1|root,COG1146@2|Bacteria,1N0QV@1224|Proteobacteria,42U2Z@68525|delta/epsilon subdivisions,2WR58@28221|Deltaproteobacteria,2MS46@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7
SX3_k127_330842_1	314271.RB2654_10713	1.956e-66	250.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase,Cadherin,FG-GAP,Glyco_hydro_26,HemolysinCabind,Integrin_beta,Lipase_GDSL_2
SX3_k127_3311789_0	439481.Aboo_0986	4.901e-90	308.0	COG0045@1|root,arCOG01337@2157|Archaea,2XTSC@28890|Euryarchaeota,3F389@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	ATP-grasp domain	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
SX3_k127_3314293_0	316067.Geob_2986	9.89e-23	114.0	COG1404@1|root,COG1572@1|root,COG1404@2|Bacteria,COG1572@2|Bacteria,1REF1@1224|Proteobacteria,42RS0@68525|delta/epsilon subdivisions,2WNDK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,Peptidase_S8
SX3_k127_3314890_6	1047013.AQSP01000137_gene558	4.599e-49	184.0	COG2866@1|root,COG2866@2|Bacteria,2NPI7@2323|unclassified Bacteria	2|Bacteria	E	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	3.4.17.18,3.4.17.22	ko:K05996,ko:K07752	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	CarboxypepD_reg,Peptidase_M14,Peptidase_M6,fn3
SX3_k127_3314890_8	673860.AciM339_1283	4.204e-32	134.0	arCOG07412@1|root,arCOG07412@2157|Archaea,2Y0S5@28890|Euryarchaeota,3F2T8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3314890_3	1054217.TALC_00020	2.024e-66	238.0	COG1395@1|root,arCOG04152@2157|Archaea,2XTMG@28890|Euryarchaeota,241RI@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-binding transcription factor activity	-	-	-	ko:K07728	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
SX3_k127_3314890_2	1236689.MMALV_00300	4.991e-81	282.0	COG1676@1|root,arCOG01701@2157|Archaea,2XTKB@28890|Euryarchaeota,3F2U2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	tRNA intron endonuclease, catalytic C-terminal domain	endA	GO:0000213,GO:0000379,GO:0000394,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0004549,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:0140101,GO:1901360	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
SX3_k127_3314890_7	945713.IALB_3117	3.873e-34	134.0	2DTJ6@1|root,33KM6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3314890_0	1304284.L21TH_0800	1.155e-234	754.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,36H9W@31979|Clostridiaceae	186801|Clostridia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01847,ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
SX3_k127_3314890_5	1121468.AUBR01000034_gene1360	1.63e-52	191.0	COG2109@1|root,COG2109@2|Bacteria,1V70U@1239|Firmicutes,24JNB@186801|Clostridia,42G6W@68295|Thermoanaerobacterales	186801|Clostridia	H	ATP corrinoid adenosyltransferase BtuR CobO CobP	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
SX3_k127_3314890_9	1321778.HMPREF1982_00872	1.689e-09	72.0	COG1501@1|root,COG4733@1|root,COG5492@1|root,COG1501@2|Bacteria,COG4733@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	3.2.1.1,3.2.1.21	ko:K01176,ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,ko04973,map00460,map00500,map00940,map01100,map01110,map04973	-	R00026,R02108,R02112,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040,R11262	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH13,GH3	-	Alpha-amylase,CBM26,CBM_6,Fn3-like,Glyco_hydro_3,Glyco_hydro_31,Glyco_hydro_3_C,Phage-tail_3,SLH
SX3_k127_3314890_4	416348.Hlac_2824	1.513e-52	212.0	COG3291@1|root,arCOG02508@2157|Archaea,2XUY6@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,PKD,Pilin_N,SdrD_B
SX3_k127_3314890_1	56780.SYN_00886	7.851e-92	317.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42NQ1@68525|delta/epsilon subdivisions,2X5KW@28221|Deltaproteobacteria,2MQH8@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Phosphofructokinase	pfkA	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
SX3_k127_3340367_6	439481.Aboo_0746	6.971e-67	233.0	COG1731@1|root,arCOG01322@2157|Archaea,2XX0K@28890|Euryarchaeota,3F2K2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	6,7-dimethyl-8-ribityllumazine synthase	ribC	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
SX3_k127_3340367_10	439481.Aboo_0747	1.039e-40	156.0	COG0615@1|root,arCOG01222@2157|Archaea,2XX70@28890|Euryarchaeota,3F2RF@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme	ribL	GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0003919,GO:0005488,GO:0005515,GO:0005524,GO:0006139,GO:0006725,GO:0006732,GO:0006747,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009161,GO:0009165,GO:0009259,GO:0009987,GO:0010181,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032553,GO:0032555,GO:0032557,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042726,GO:0042727,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046443,GO:0046444,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072387,GO:0072388,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.7.2	ko:K14656	ko00740,ko01100,ko01110,map00740,map01100,map01110	-	R00161	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
SX3_k127_3340367_5	644281.MFS40622_0449	4.024e-69	243.0	COG0108@1|root,arCOG01320@2157|Archaea,2XTDZ@28890|Euryarchaeota,23Q9J@183939|Methanococci	183939|Methanococci	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008686,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016829,GO:0016830,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.12	ko:K02858	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R07281	RC01792,RC01815	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase
SX3_k127_3340367_7	523845.AQXV01000026_gene1469	2.644e-65	255.0	arCOG02545@1|root,arCOG02545@2157|Archaea	2157|Archaea	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NosD,PKD
SX3_k127_3340367_11	673860.AciM339_0272	7.361e-27	119.0	arCOG03379@1|root,arCOG03379@2157|Archaea,2XZH1@28890|Euryarchaeota,3F2PN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3340367_15	590998.Celf_3522	2.338e-07	65.0	COG3468@1|root,COG4932@1|root,COG3468@2|Bacteria,COG4932@2|Bacteria,2HCJX@201174|Actinobacteria	201174|Actinobacteria	MU	ig-like, plexins, transcription factors	-	-	-	-	-	-	-	-	-	-	-	-	B_lectin,CHAP,TIG
SX3_k127_3340367_9	273075.Ta1457	4.732e-47	172.0	COG1545@1|root,arCOG01285@2157|Archaea,2XXGF@28890|Euryarchaeota,241SY@183967|Thermoplasmata	183967|Thermoplasmata	V	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
SX3_k127_3340367_1	368407.Memar_2362	3.78e-127	417.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,2N94P@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM Thiolase	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF692.Mbar_A0550	Thiolase_C,Thiolase_N
SX3_k127_3340367_0	368407.Memar_2361	1.585e-141	456.0	COG3425@1|root,arCOG01767@2157|Archaea,2XTWE@28890|Euryarchaeota,2N99Q@224756|Methanomicrobia	224756|Methanomicrobia	I	3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III_C,HMG_CoA_synt_N
SX3_k127_3340367_4	673860.AciM339_0347	4.711e-71	249.0	COG1709@1|root,arCOG04060@2157|Archaea,2XT58@28890|Euryarchaeota,3F2M5@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K07731	-	-	-	-	ko00000,ko03000	-	-	-	HTH_19,HTH_3,HTH_31
SX3_k127_3340367_3	644966.Tmar_0853	7.068e-98	331.0	COG0809@1|root,COG0809@2|Bacteria,1TPKD@1239|Firmicutes,247NT@186801|Clostridia,3WCFH@538999|Clostridiales incertae sedis	186801|Clostridia	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
SX3_k127_3340367_2	1382304.JNIL01000001_gene1065	3.058e-100	340.0	COG0343@1|root,COG0343@2|Bacteria,1TNZ4@1239|Firmicutes,4HCNM@91061|Bacilli,27827@186823|Alicyclobacillaceae	91061|Bacilli	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
SX3_k127_3340367_12	383372.Rcas_3603	5.1e-21	102.0	COG1100@1|root,COG1100@2|Bacteria,2G9IC@200795|Chloroflexi,3777W@32061|Chloroflexia	32061|Chloroflexia	S	SMART Ras small GTPase, Ras type	-	-	-	-	-	-	-	-	-	-	-	-	Ras
SX3_k127_3340367_8	693661.Arcve_1184	8.422e-62	241.0	COG2512@1|root,arCOG03799@1|root,arCOG06712@1|root,arCOG00374@2157|Archaea,arCOG03799@2157|Archaea,arCOG06712@2157|Archaea,2XYJJ@28890|Euryarchaeota	28890|Euryarchaeota	T	Pas domain s-box	-	-	-	-	-	-	-	-	-	-	-	-	DUF835,HAMP,HATPase_c,PAS
SX3_k127_3340367_14	631362.Thi970DRAFT_02254	2.957e-13	74.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WZWS@135613|Chromatiales	135613|Chromatiales	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3,PAS_4,PAS_9
SX3_k127_3340367_13	102125.Xen7305DRAFT_00030960	1.36e-17	98.0	COG1572@1|root,COG1864@1|root,COG2931@1|root,COG3209@1|root,COG3291@1|root,COG3386@1|root,COG3391@1|root,COG1572@2|Bacteria,COG1864@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,COG3291@2|Bacteria,COG3386@2|Bacteria,COG3391@2|Bacteria,1G2S3@1117|Cyanobacteria,3VJDP@52604|Pleurocapsales	1117|Cyanobacteria	GQ	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,Polysacc_deac_1
SX3_k127_3355617_7	439481.Aboo_1462	9.162e-09	70.0	COG1572@1|root,COG4934@1|root,arCOG02532@2157|Archaea,arCOG03669@2157|Archaea,2Y7X2@28890|Euryarchaeota,3F35Y@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Pro-kumamolisin, activation domain	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,CarboxypepD_reg,Pro-kuma_activ
SX3_k127_3355617_4	1094980.Mpsy_2611	2.42e-30	132.0	COG0745@1|root,arCOG02348@1|root,arCOG03799@1|root,arCOG02348@2157|Archaea,arCOG02592@2157|Archaea,arCOG03799@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF835)	-	-	2.7.7.65,6.3.4.2	ko:K01937,ko:K02488	ko00240,ko01100,ko02020,ko04112,map00240,map01100,map02020,map04112	M00052,M00511	R00571,R00573,R08057	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	DUF835,GAF_3,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
SX3_k127_3355617_6	1041930.Mtc_0180	2.089e-13	80.0	COG2093@1|root,arCOG04077@2157|Archaea,2Y0D6@28890|Euryarchaeota,2NA1J@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcription elongation factor Spt4	spt4	-	2.7.7.6	ko:K03050	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Spt4
SX3_k127_3355617_1	1236689.MMALV_04370	4.008e-60	213.0	COG1095@1|root,arCOG00675@2157|Archaea,2XT6U@28890|Euryarchaeota,3F2MN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397	rpoE1	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03049	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	S1,SHS2_Rpb7-N
SX3_k127_3355617_5	211114.JOEF01000044_gene6122	4.617e-18	100.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIRS@201174|Actinobacteria,4E0I8@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,NB-ARC,TPR_10,TPR_12,TPR_7,Trans_reg_C
SX3_k127_3355617_3	673860.AciM339_0977	2.381e-42	158.0	COG0051@1|root,arCOG01758@2157|Archaea,2XXV8@28890|Euryarchaeota,3F2QH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Involved in the binding of tRNA to the ribosomes	rps10	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
SX3_k127_3355617_0	368407.Memar_0730	8.242e-190	622.0	COG5256@1|root,arCOG01561@2157|Archaea,2XTNM@28890|Euryarchaeota,2N9FZ@224756|Methanomicrobia	224756|Methanomicrobia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
SX3_k127_3355617_2	386456.JQKN01000008_gene1388	6.025e-59	219.0	arCOG02665@1|root,arCOG02665@2157|Archaea,2Y893@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3374077_2	195253.Syn6312_0275	1.198e-28	127.0	COG0467@1|root,COG0467@2|Bacteria,1G0KY@1117|Cyanobacteria,1GZB7@1129|Synechococcus	1117|Cyanobacteria	F	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction	kaiC	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007623,GO:0008150,GO:0008152,GO:0009605,GO:0009649,GO:0009966,GO:0009987,GO:0010646,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019538,GO:0023051,GO:0036211,GO:0042752,GO:0042754,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0048511,GO:0048519,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0070297,GO:0071704,GO:1901564,GO:1902531	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
SX3_k127_3374077_6	1183377.Py04_0594	5.595e-13	78.0	COG1681@1|root,arCOG01829@2157|Archaea,2Y36F@28890|Euryarchaeota,243VC@183968|Thermococci	183968|Thermococci	N	Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella	-	GO:0005575,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464	-	ko:K07325	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Arch_flagellin
SX3_k127_3374077_3	439481.Aboo_0143	2.465e-26	123.0	COG3351@1|root,arCOG02964@2157|Archaea,2XVP0@28890|Euryarchaeota,3F2YQ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	N	Flagella accessory protein C (FlaC)	flaD	-	-	ko:K07327,ko:K07328	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Arch_fla_DE,FlaC_arch
SX3_k127_3374077_5	1210908.HSB1_08960	4.532e-13	74.0	COG3353@1|root,arCOG01824@2157|Archaea,2XYQP@28890|Euryarchaeota,23WWZ@183963|Halobacteria	183963|Halobacteria	N	archaeal flagellar protein F	flaF	-	-	ko:K07329	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Arch_flagellin
SX3_k127_3374077_4	693661.Arcve_1473	6.292e-15	80.0	COG3354@1|root,arCOG01822@2157|Archaea,2Y6D9@28890|Euryarchaeota,247H2@183980|Archaeoglobi	183980|Archaeoglobi	N	Archaebacterial flagellin	-	-	-	ko:K07330	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Arch_flagellin
SX3_k127_3374077_1	439481.Aboo_0139	2.347e-73	269.0	COG4906@1|root,arCOG00568@2157|Archaea	2157|Archaea	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2206
SX3_k127_3374077_0	1158338.JNLJ01000001_gene812	1.283e-127	417.0	COG1053@1|root,COG1053@2|Bacteria,2G3PJ@200783|Aquificae	200783|Aquificae	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein	sdhA	-	1.3.1.6,1.3.5.1,1.3.5.4	ko:K00239,ko:K18556	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R00402,R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
SX3_k127_337441_10	1293048.CBMB010000010_gene3721	2.775e-13	78.0	arCOG05472@1|root,arCOG05472@2157|Archaea,2XZ9X@28890|Euryarchaeota,23UIV@183963|Halobacteria	183963|Halobacteria	S	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_337441_3	439481.Aboo_0227	7.568e-63	225.0	COG1650@1|root,arCOG01616@2157|Archaea,2XUM0@28890|Euryarchaeota,3F2M2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
SX3_k127_337441_2	742740.HMPREF9474_00523	1.907e-72	261.0	COG1032@1|root,COG1032@2|Bacteria,1TQF0@1239|Firmicutes,24A0T@186801|Clostridia,2210X@1506553|Lachnoclostridium	186801|Clostridia	C	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SX3_k127_337441_6	109760.SPPG_09273T0	1.673e-28	121.0	COG1896@1|root,KOG3197@2759|Eukaryota,38FZH@33154|Opisthokonta,3NWF9@4751|Fungi	4751|Fungi	F	Hd domain-containing protein	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0016787,GO:0016788,GO:0042578,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464	-	ko:K07023	-	-	-	-	ko00000	-	-	-	HD_3
SX3_k127_337441_1	264462.Bd0328	4.451e-88	329.0	COG0457@1|root,COG0457@2|Bacteria,1QY1G@1224|Proteobacteria,43C8T@68525|delta/epsilon subdivisions,2MUD4@213481|Bdellovibrionales,2X7J5@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
SX3_k127_337441_4	416348.Hlac_2824	1.495e-56	227.0	COG3291@1|root,arCOG02508@2157|Archaea,2XUY6@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,PKD,Pilin_N,SdrD_B
SX3_k127_337441_8	1121405.dsmv_0802	7.215e-21	96.0	COG0399@1|root,COG0399@2|Bacteria,1N0QW@1224|Proteobacteria,42W70@68525|delta/epsilon subdivisions,2WRUT@28221|Deltaproteobacteria,2MNXP@213118|Desulfobacterales	28221|Deltaproteobacteria	J	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
SX3_k127_337441_5	673860.AciM339_0588	8.137e-40	159.0	COG1387@1|root,arCOG00304@2157|Archaea,2Y725@28890|Euryarchaeota,3F38C@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	DNA polymerase alpha chain like domain	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	PHP
SX3_k127_337441_0	1209989.TepiRe1_2813	4.539e-192	608.0	COG2403@1|root,COG2403@2|Bacteria,1TPZD@1239|Firmicutes,24E2D@186801|Clostridia,42HSE@68295|Thermoanaerobacterales	186801|Clostridia	S	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
SX3_k127_337441_9	679926.Mpet_1937	2.638e-20	108.0	COG2319@1|root,arCOG02491@2157|Archaea,2XZY9@28890|Euryarchaeota,2NB16@224756|Methanomicrobia	224756|Methanomicrobia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,WD40
SX3_k127_337441_7	240016.ABIZ01000001_gene4418	9.101e-23	102.0	COG0399@1|root,COG0399@2|Bacteria,46T3Z@74201|Verrucomicrobia,2IWJE@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
SX3_k127_3381413_0	1318628.MARLIPOL_09971	3.325e-31	141.0	COG1372@1|root,COG1520@1|root,COG3209@1|root,COG1372@2|Bacteria,COG1520@2|Bacteria,COG3209@2|Bacteria,1QW4H@1224|Proteobacteria,1T42N@1236|Gammaproteobacteria,46DDZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	LM	Rhs Family	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,DUF5122,He_PIG,PT-HINT,RHS_repeat
SX3_k127_339355_0	1054217.TALC_00160	1.641e-157	509.0	COG1222@1|root,arCOG01306@2157|Archaea	2157|Archaea	O	ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates	pan	GO:0000502,GO:0003674,GO:0003824,GO:0003924,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0022623,GO:0022624,GO:0030163,GO:0032991,GO:0043170,GO:0043273,GO:0043335,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	-	ko:K03420	ko03050,map03050	M00343	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA,Prot_ATP_ID_OB
SX3_k127_339355_15	224325.AF_1977	4.124e-19	97.0	COG1813@1|root,arCOG01863@2157|Archaea,2XXND@28890|Euryarchaeota,24732@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator, XRE family	-	-	-	ko:K03627	-	-	-	-	ko00000	-	-	-	HTH_3
SX3_k127_339355_8	1227495.C487_16634	2.947e-64	248.0	COG1033@1|root,arCOG02174@2157|Archaea,2XT5A@28890|Euryarchaeota,23SV0@183963|Halobacteria	183963|Halobacteria	L	exporters of the RND superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MMPL
SX3_k127_339355_6	373994.Riv7116_1673	1.375e-72	278.0	COG3209@1|root,COG3209@2|Bacteria,1GQ0G@1117|Cyanobacteria,1HN8U@1161|Nostocales	1117|Cyanobacteria	MU	Dystroglycan-type cadherin-like domains.	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,He_PIG,RHS_repeat
SX3_k127_339355_11	1278073.MYSTI_05406	1.765e-38	155.0	COG0476@1|root,COG0476@2|Bacteria	2|Bacteria	H	Involved in molybdopterin and thiamine biosynthesis, family 2	moeB	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
SX3_k127_339355_18	673860.AciM339_0080	1.205e-12	84.0	COG1196@1|root,COG1361@1|root,arCOG05232@1|root,arCOG06883@1|root,arCOG00371@2157|Archaea,arCOG04400@2157|Archaea,arCOG05232@2157|Archaea,arCOG06883@2157|Archaea	2157|Archaea	S	Tubulin like	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,DUF2334,DZR,Tubulin_2
SX3_k127_339355_20	103372.F4WFQ9	1.683e-10	68.0	COG5078@1|root,KOG0421@2759|Eukaryota,38MK7@33154|Opisthokonta,3BICF@33208|Metazoa,3CSMQ@33213|Bilateria,41Z76@6656|Arthropoda,3SM1S@50557|Insecta,46GGG@7399|Hymenoptera	33208|Metazoa	O	Ubiquitin-conjugating enzyme E2, catalytic domain homologues	UBE2C	GO:0000151,GO:0000152,GO:0000209,GO:0000278,GO:0000280,GO:0003674,GO:0003824,GO:0004842,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005680,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0006996,GO:0007049,GO:0007088,GO:0007096,GO:0007346,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010458,GO:0010498,GO:0010564,GO:0010604,GO:0010638,GO:0010965,GO:0010992,GO:0010994,GO:0016020,GO:0016043,GO:0016567,GO:0016740,GO:0019222,GO:0019538,GO:0019725,GO:0019787,GO:0019899,GO:0019941,GO:0022402,GO:0022607,GO:0030071,GO:0030163,GO:0031145,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0031396,GO:0031398,GO:0031399,GO:0031401,GO:0031461,GO:0031536,GO:0031625,GO:0031974,GO:0031981,GO:0032268,GO:0032270,GO:0032436,GO:0032446,GO:0032991,GO:0033043,GO:0033044,GO:0033045,GO:0033047,GO:0034622,GO:0036211,GO:0042176,GO:0042592,GO:0043085,GO:0043161,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043632,GO:0043933,GO:0044085,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044389,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0044770,GO:0044772,GO:0045732,GO:0045787,GO:0045840,GO:0045842,GO:0045862,GO:0045931,GO:0048285,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051258,GO:0051338,GO:0051347,GO:0051438,GO:0051443,GO:0051603,GO:0051726,GO:0051781,GO:0051783,GO:0051785,GO:0051983,GO:0051984,GO:0060255,GO:0061630,GO:0061631,GO:0061650,GO:0061659,GO:0062033,GO:0065003,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070647,GO:0070936,GO:0070979,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090068,GO:0140014,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1901800,GO:1901970,GO:1901987,GO:1901989,GO:1901990,GO:1901992,GO:1902099,GO:1902101,GO:1902494,GO:1903047,GO:1903052,GO:1903320,GO:1903322,GO:1903362,GO:1903364,GO:1904666,GO:1904668,GO:1905818,GO:1905820,GO:1990234,GO:2001252	2.3.2.23	ko:K06688,ko:K08707	ko04120,map04120	-	-	-	ko00000,ko00001,ko01000,ko04121	-	-	-	UQ_con
SX3_k127_339355_19	33169.AAS54495	1.579e-12	78.0	COG1310@1|root,KOG1555@2759|Eukaryota,38G6Q@33154|Opisthokonta,3NV6C@4751|Fungi,3QQWZ@4890|Ascomycota,3RS8W@4891|Saccharomycetes,3RYM8@4893|Saccharomycetaceae	4751|Fungi	O	to Saccharomyces cerevisiae RPN11 (YFR004W)	RPN11	GO:0000266,GO:0000502,GO:0003674,GO:0003824,GO:0004843,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0005838,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0006996,GO:0007005,GO:0007031,GO:0007088,GO:0007346,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0008237,GO:0008541,GO:0009056,GO:0009057,GO:0009896,GO:0009987,GO:0010498,GO:0010564,GO:0010638,GO:0010965,GO:0016043,GO:0016559,GO:0016579,GO:0016787,GO:0019538,GO:0019783,GO:0019941,GO:0022607,GO:0022624,GO:0030071,GO:0030163,GO:0031331,GO:0031597,GO:0031974,GO:0031981,GO:0032270,GO:0032436,GO:0032991,GO:0033043,GO:0033044,GO:0033045,GO:0033047,GO:0034399,GO:0034515,GO:0034622,GO:0036211,GO:0036459,GO:0043161,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043248,GO:0043412,GO:0043632,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045732,GO:0045787,GO:0045840,GO:0045842,GO:0045862,GO:0045931,GO:0048285,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051247,GO:0051603,GO:0051726,GO:0051781,GO:0051783,GO:0051785,GO:0051983,GO:0051984,GO:0062033,GO:0065003,GO:0065007,GO:0070011,GO:0070013,GO:0070646,GO:0070647,GO:0071704,GO:0071840,GO:0090068,GO:0101005,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1901800,GO:1901970,GO:1901987,GO:1901989,GO:1901990,GO:1901992,GO:1902099,GO:1902101,GO:1902494,GO:1902906,GO:1903052,GO:1903364,GO:1905368,GO:1905369,GO:1905818,GO:1905820,GO:2001252	-	ko:K03030	ko03050,ko05169,map03050,map05169	M00341	-	-	ko00000,ko00001,ko00002,ko01002,ko03051,ko04121	-	-	-	JAB,MitMem_reg
SX3_k127_339355_4	673860.AciM339_0881	1.887e-111	372.0	COG0473@1|root,arCOG01163@2157|Archaea,2XT99@28890|Euryarchaeota,3F2NP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Isocitrate/isopropylmalate dehydrogenase	leuB	GO:0006082,GO:0006575,GO:0006732,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016053,GO:0019297,GO:0019298,GO:0019752,GO:0032787,GO:0042398,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576	1.1.1.85,1.1.1.87	ko:K00052,ko:K10978	ko00290,ko00300,ko00660,ko00680,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00300,map00660,map00680,map01100,map01110,map01120,map01130,map01210,map01230	M00432,M00535,M00608	R00994,R01934,R01936,R04426,R04862,R08214,R08215,R10052	RC00084,RC00114,RC00417,RC00626,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
SX3_k127_339355_12	1449126.JQKL01000037_gene2053	2.855e-37	155.0	COG0066@1|root,COG0066@2|Bacteria,1V1I6@1239|Firmicutes,24FUI@186801|Clostridia,268P4@186813|unclassified Clostridiales	186801|Clostridia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
SX3_k127_339355_3	439481.Aboo_0129	3.657e-132	433.0	COG0065@1|root,arCOG01698@2157|Archaea,2XTWH@28890|Euryarchaeota,3F31B@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.114,4.2.1.33,4.2.1.35	ko:K01703,ko:K16792	ko00290,ko00300,ko00660,ko00680,ko00966,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00300,map00660,map00680,map00966,map01100,map01110,map01120,map01130,map01210,map01230	M00432,M00433,M00535,M00608	R03444,R03896,R03898,R03968,R04001,R04371,R08620,R08624,R08628,R08634,R08641,R08645,R09720,R10170,R10391,R10392,R10393,R10394,R10395,R10396	RC00497,RC00498,RC00618,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
SX3_k127_339355_16	1123072.AUDH01000021_gene2024	1.23e-17	87.0	COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,2U7A8@28211|Alphaproteobacteria,2JS47@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
SX3_k127_339355_2	1054217.TALC_01456	2.221e-133	435.0	COG0533@1|root,arCOG01183@2157|Archaea,2Y86G@28890|Euryarchaeota	28890|Euryarchaeota	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity	kae1	GO:0000049,GO:0000408,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003727,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
SX3_k127_339355_10	529709.PYCH_18600	4.11e-44	177.0	COG0533@1|root,arCOG01185@2157|Archaea,2XX5D@28890|Euryarchaeota,2436E@183968|Thermococci	183968|Thermococci	T	serine threonine protein kinase	-	GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.7.11.1	ko:K08851	-	-	-	-	ko00000,ko01000,ko01001,ko03016	-	-	-	RIO1
SX3_k127_339355_9	529709.PYCH_13260	8.342e-53	192.0	COG0127@1|root,arCOG04184@2157|Archaea,2XTS4@28890|Euryarchaeota,243RS@183968|Thermococci	183968|Thermococci	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
SX3_k127_339355_21	673860.AciM339_0534	8.506e-07	60.0	arCOG02206@1|root,arCOG02206@2157|Archaea,2Y10D@28890|Euryarchaeota,3F34Z@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	ribosomal small subunit binding	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_339355_7	391625.PPSIR1_02878	1.093e-67	250.0	COG2820@1|root,COG2820@2|Bacteria,1P0EC@1224|Proteobacteria,43CGE@68525|delta/epsilon subdivisions	1224|Proteobacteria	F	Phosphorylase superfamily	udp	GO:0003674,GO:0003824,GO:0004850,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006218,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009116,GO:0009119,GO:0009164,GO:0009987,GO:0016043,GO:0016740,GO:0016757,GO:0016763,GO:0019439,GO:0022607,GO:0030955,GO:0031420,GO:0033554,GO:0034214,GO:0034641,GO:0034655,GO:0034656,GO:0042454,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046108,GO:0046131,GO:0046133,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0050896,GO:0051259,GO:0051716,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_2630,iB21_1397.B21_03667,iECABU_c1320.ECABU_c43290,iECBD_1354.ECBD_4198,iECB_1328.ECB_03718,iECD_1391.ECD_03718,iECNA114_1301.ECNA114_4136,iECOK1_1307.ECOK1_4296,iECP_1309.ECP_4040,iECS88_1305.ECS88_4275,iECSF_1327.ECSF_3683,iEcSMS35_1347.EcSMS35_4208,iLF82_1304.LF82_2357,iNRG857_1313.NRG857_19105,iUMN146_1321.UM146_19385,iUMNK88_1353.UMNK88_4655	PNP_UDP_1
SX3_k127_339355_13	634497.HAH_0603	3.359e-30	124.0	COG1522@1|root,arCOG01580@2157|Archaea,2XX5M@28890|Euryarchaeota,23VKV@183963|Halobacteria	183963|Halobacteria	K	COG1522 Transcriptional regulators	trh3	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_AsnC-type
SX3_k127_339355_17	1123388.AQWU01000044_gene2233	1.134e-14	74.0	2EC2Y@1|root,3361X@2|Bacteria,1WKKQ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	TIGRFAM Lysine biosynthesis protein LysW	lysW	-	-	ko:K05826	-	M00031,M00763	-	-	ko00000,ko00001,ko00002	-	-	-	TF_Zn_Ribbon
SX3_k127_339355_5	867845.KI911784_gene2370	4.755e-109	362.0	COG0189@1|root,COG0189@2|Bacteria,2G5RN@200795|Chloroflexi,374VK@32061|Chloroflexia	32061|Chloroflexia	HJ	PFAM ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp	-	-	6.3.2.43	ko:K05827	ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230	M00031	R09775	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	RimK
SX3_k127_339355_1	525904.Tter_0319	1.404e-133	440.0	COG0002@1|root,COG0002@2|Bacteria,2NNN5@2323|unclassified Bacteria	2|Bacteria	E	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily	argC	-	1.2.1.38	ko:K00145,ko:K05829	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00028,M00031,M00763,M00845	R03443,R09777,R10931	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
SX3_k127_339355_14	383372.Rcas_3466	5.867e-26	109.0	COG0548@1|root,COG0548@2|Bacteria,2G5WV@200795|Chloroflexi,375DI@32061|Chloroflexia	32061|Chloroflexia	E	Belongs to the acetylglutamate kinase family. LysZ subfamily	lysZ	-	-	ko:K05828	ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230	M00031,M00763	R09776,R10930	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
SX3_k127_3412736_1	1089551.KE386572_gene1743	2.411e-48	200.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,2U12Y@28211|Alphaproteobacteria,4BRG6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
SX3_k127_3412736_0	926569.ANT_05100	1.09e-90	306.0	COG2326@1|root,COG2326@2|Bacteria,2G5UP@200795|Chloroflexi	200795|Chloroflexi	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
SX3_k127_3412736_2	926554.KI912660_gene2372	5.059e-29	133.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PPC,Peptidase_S8
SX3_k127_3440835_4	215803.DB30_2423	6.379e-06	59.0	COG1404@1|root,COG3291@1|root,COG3509@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,COG3509@2|Bacteria,1MU3S@1224|Proteobacteria,42N7D@68525|delta/epsilon subdivisions,2WKJS@28221|Deltaproteobacteria,2YZ9E@29|Myxococcales	28221|Deltaproteobacteria	OQ	Bacterial Ig-like domain (group 3)	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Big_3_3,Inhibitor_I9,Peptidase_S8
SX3_k127_3440835_3	1480694.DC28_04080	6.454e-21	109.0	COG0841@1|root,COG3420@1|root,COG0841@2|Bacteria,COG3420@2|Bacteria,2J58E@203691|Spirochaetes	203691|Spirochaetes	P	this gene contains a nucleotide ambiguity which may be the result of a sequencing error	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,Big_3_3
SX3_k127_3440835_1	1041930.Mtc_0093	4.175e-43	173.0	COG0301@1|root,arCOG00038@2157|Archaea,2XUHM@28890|Euryarchaeota,2N98H@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
SX3_k127_3440835_2	304371.MCP_2020	1.573e-24	111.0	COG0576@1|root,arCOG04772@2157|Archaea,2XUCA@28890|Euryarchaeota,2NA0X@224756|Methanomicrobia	224756|Methanomicrobia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
SX3_k127_3440835_0	247490.KSU1_C1370	8.669e-98	321.0	COG0443@1|root,COG0443@2|Bacteria,2IWWS@203682|Planctomycetes	203682|Planctomycetes	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
SX3_k127_3444055_0	871968.DESME_09140	3.718e-45	189.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	HYR,PQQ_2
SX3_k127_3444059_1	1333523.L593_10665	2.664e-21	111.0	COG3291@1|root,COG3325@1|root,arCOG02546@2157|Archaea,arCOG07840@2157|Archaea,2XWCV@28890|Euryarchaeota,23TJG@183963|Halobacteria	183963|Halobacteria	G	protein contain chitin-binding domain type 3	-	-	-	-	-	-	-	-	-	-	-	-	PKD
SX3_k127_3444059_4	215803.DB30_5213	0.0003577	54.0	COG1409@1|root,COG3291@1|root,COG1409@2|Bacteria,COG3291@2|Bacteria,1N85S@1224|Proteobacteria,42WZ6@68525|delta/epsilon subdivisions,2XA07@28221|Deltaproteobacteria,2YZHM@29|Myxococcales	28221|Deltaproteobacteria	S	PKD domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,PKD
SX3_k127_3444059_3	192952.MM_2441	1.311e-05	59.0	COG3398@1|root,arCOG02611@2157|Archaea,2XV4M@28890|Euryarchaeota,2NB4N@224756|Methanomicrobia	224756|Methanomicrobia	K	Winged helix-turn-helix DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
SX3_k127_3444059_0	877455.Metbo_0633	4.801e-59	211.0	COG0586@1|root,arCOG03117@2157|Archaea,2XY9U@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM SNARE associated Golgi protein	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
SX3_k127_3444059_2	673860.AciM339_1575	8.286e-20	94.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y4JI@28890|Euryarchaeota,3F328@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	DnaB-like helicase C terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
SX3_k127_3460502_1	673860.AciM339_0995	4.831e-75	289.0	COG1572@1|root,COG2304@1|root,arCOG02420@1|root,arCOG07560@1|root,arCOG02420@2157|Archaea,arCOG02532@2157|Archaea,arCOG02900@2157|Archaea,arCOG07560@2157|Archaea	2157|Archaea	Q	Archaeal Type IV pilin, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,CARDB,CarboxypepD_reg,DUF3344,PKD,Pilin_N,VWA_2
SX3_k127_3460502_0	439481.Aboo_0945	6.575e-87	321.0	COG1470@1|root,COG1572@1|root,COG2304@1|root,arCOG02420@1|root,arCOG02081@2157|Archaea,arCOG02420@2157|Archaea,arCOG02532@2157|Archaea,arCOG02902@2157|Archaea	2157|Archaea	O	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,CARDB,CarboxypepD_reg,NPCBM_assoc,Pilin_N,VWA,VWA_2
SX3_k127_3478441_11	1232410.KI421413_gene574	0.0001641	52.0	COG1404@1|root,COG1520@1|root,COG1404@2|Bacteria,COG1520@2|Bacteria,1MU3S@1224|Proteobacteria,42SPI@68525|delta/epsilon subdivisions	1224|Proteobacteria	O	COG1404 Subtilisin-like serine proteases	-	-	3.4.21.111	ko:K12685,ko:K20754	-	-	-	-	ko00000,ko01000,ko01002,ko02000,ko02044	1.B.12.5.1,1.B.12.5.3	-	-	Inhibitor_I9,Peptidase_S8
SX3_k127_3478441_3	867845.KI911784_gene2277	9.776e-80	301.0	COG0457@1|root,COG1404@1|root,COG3055@1|root,COG0457@2|Bacteria,COG1404@2|Bacteria,COG3055@2|Bacteria,2G8UU@200795|Chloroflexi,3759F@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4,Kelch_5,Peptidase_S8
SX3_k127_3478441_9	373994.Riv7116_1673	4.434e-16	94.0	COG3209@1|root,COG3209@2|Bacteria,1GQ0G@1117|Cyanobacteria,1HN8U@1161|Nostocales	1117|Cyanobacteria	MU	Dystroglycan-type cadherin-like domains.	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,He_PIG,RHS_repeat
SX3_k127_3478441_12	1209984.BN978_00040	0.000308	55.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria,2335B@1762|Mycobacteriaceae	201174|Actinobacteria	S	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
SX3_k127_3478441_5	765420.OSCT_0910	7.254e-66	257.0	COG0457@1|root,COG1716@1|root,COG4447@1|root,COG0457@2|Bacteria,COG1716@2|Bacteria,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CarboxypepD_reg,FHA,Kelch_4,NHL,PA14,Peptidase_C11
SX3_k127_3478441_10	344747.PM8797T_02424	3.662e-14	87.0	COG1404@1|root,COG2931@1|root,COG3209@1|root,COG3210@1|root,COG4932@1|root,COG5276@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,COG4932@2|Bacteria,COG5276@2|Bacteria	2|Bacteria	M	domain protein	-	-	3.2.1.4,3.4.21.62,3.4.24.40	ko:K01179,ko:K01342,ko:K01406,ko:K07004,ko:K12287,ko:K14194,ko:K15125,ko:K20276	ko00500,ko01100,ko01503,ko02024,ko05133,ko05150,map00500,map01100,map01503,map02024,map05133,map05150	-	R06200,R11307,R11308	-	ko00000,ko00001,ko00536,ko01000,ko01002,ko02044,ko03110	-	GH5,GH9	-	Calx-beta,Exo_endo_phos,HemolysinCabind,VCBS
SX3_k127_3478441_7	411467.BACCAP_01162	1.021e-27	123.0	COG0652@1|root,COG0652@2|Bacteria,1V1SP@1239|Firmicutes,24G4H@186801|Clostridia,26BC4@186813|unclassified Clostridiales	186801|Clostridia	O	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	Pro_isomerase
SX3_k127_3478441_8	111780.Sta7437_2551	1.155e-20	102.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria,3VJQ2@52604|Pleurocapsales	1117|Cyanobacteria	O	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
SX3_k127_3478441_0	1236689.MMALV_10340	3.37e-149	495.0	COG0175@1|root,arCOG00073@2157|Archaea,2XUPU@28890|Euryarchaeota,3F2GA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Phosphoadenosine phosphosulfate reductase family	-	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0559	Fer4,Fer4_10,Fer4_7,PAPS_reduct,PUA
SX3_k127_3478441_4	415426.Hbut_0632	4.746e-67	235.0	COG2518@1|root,arCOG00976@2157|Archaea,2XPYU@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
SX3_k127_3478441_2	323259.Mhun_2322	6.733e-136	444.0	COG0214@1|root,arCOG04075@2157|Archaea,2XSYK@28890|Euryarchaeota,2N9DB@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
SX3_k127_3478441_1	909663.KI867150_gene2168	1.009e-140	465.0	COG0519@1|root,COG0519@2|Bacteria,1NR5X@1224|Proteobacteria,42YTH@68525|delta/epsilon subdivisions,2WUIJ@28221|Deltaproteobacteria,2MR8H@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	GMP synthase C terminal domain	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GMP_synt_C,NAD_synthase
SX3_k127_3478441_6	523850.TON_1891	4.01e-29	121.0	COG0311@1|root,arCOG00034@2157|Archaea,2XTZS@28890|Euryarchaeota,242MN@183968|Thermococci	183968|Thermococci	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
SX3_k127_3483838_0	555088.DealDRAFT_2804	2.051e-263	831.0	COG1331@1|root,COG1331@2|Bacteria,1TPRD@1239|Firmicutes,248PD@186801|Clostridia	186801|Clostridia	O	Highly conserved protein containing a thioredoxin domain	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
SX3_k127_3483838_5	309799.DICTH_1716	3.918e-54	199.0	COG2193@1|root,COG2193@2|Bacteria	2|Bacteria	P	ferroxidase activity	bfr	GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
SX3_k127_3483838_2	1286171.EAL2_808p04300	5.729e-128	424.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1TPE2@1239|Firmicutes,25CRU@186801|Clostridia	186801|Clostridia	P	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SX3_k127_3483838_6	891968.Anamo_1805	1.071e-51	207.0	COG0477@1|root,COG2814@2|Bacteria,3TAXB@508458|Synergistetes	508458|Synergistetes	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
SX3_k127_3483838_1	565033.GACE_0763	5.641e-157	519.0	COG4231@1|root,arCOG01609@2157|Archaea,2XUNR@28890|Euryarchaeota,246UD@183980|Archaeoglobi	183980|Archaeoglobi	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
SX3_k127_3483838_7	246969.TAM4_762	8.737e-41	159.0	COG1014@1|root,arCOG01602@2157|Archaea,2XXK2@28890|Euryarchaeota,242YZ@183968|Thermococci	183968|Thermococci	C	Indolepyruvate ferredoxin oxidoreductase subunit	iorB-1	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
SX3_k127_3483838_4	868864.Dester_0419	8.353e-56	214.0	COG0471@1|root,COG0471@2|Bacteria,2G3NJ@200783|Aquificae	200783|Aquificae	P	PFAM Sodium sulphate symporter	-	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
SX3_k127_3483838_3	292459.STH260	9.889e-76	274.0	COG4756@1|root,COG4756@2|Bacteria,1TR8T@1239|Firmicutes,24AUH@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF1646)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1646
SX3_k127_3483838_8	446462.Amir_1555	2.407e-07	61.0	COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria,4DYIP@85010|Pseudonocardiales	201174|Actinobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
SX3_k127_3494781_0	1089548.KI783301_gene357	1.003e-60	233.0	COG0437@1|root,COG0437@2|Bacteria,1TT2G@1239|Firmicutes,4HII4@91061|Bacilli	91061|Bacilli	C	4Fe-4S ferredoxin	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_11,Ferredoxin_N
SX3_k127_3544152_4	273116.14325487	2.453e-16	83.0	COG1758@1|root,arCOG01268@2157|Archaea,2XZSW@28890|Euryarchaeota,241WT@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoK	-	2.7.7.6	ko:K03055	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb6
SX3_k127_3544152_0	439481.Aboo_1303	3.214e-132	438.0	COG0148@1|root,arCOG01169@2157|Archaea,2XSXT@28890|Euryarchaeota,3F2J7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
SX3_k127_3544152_2	1236689.MMALV_01570	5.516e-87	291.0	COG0052@1|root,arCOG04245@2157|Archaea,2XTHM@28890|Euryarchaeota,3F2J8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the universal ribosomal protein uS2 family	rps2	GO:0000028,GO:0000447,GO:0000460,GO:0000461,GO:0000462,GO:0000466,GO:0000469,GO:0000478,GO:0000479,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0031123,GO:0031125,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043628,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
SX3_k127_3544152_3	877455.Metbo_0817	5.004e-71	252.0	COG1355@1|root,arCOG01728@2157|Archaea,2XVYU@28890|Euryarchaeota,23P13@183925|Methanobacteria	183925|Methanobacteria	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
SX3_k127_3544152_5	215803.DB30_0756	0.0001891	53.0	COG1629@1|root,COG4771@2|Bacteria,1PEGK@1224|Proteobacteria,43A3B@68525|delta/epsilon subdivisions,2X9UE@28221|Deltaproteobacteria,2YW7T@29|Myxococcales	28221|Deltaproteobacteria	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
SX3_k127_3544152_1	415426.Hbut_0202	2.861e-100	335.0	COG0074@1|root,arCOG01339@2157|Archaea,2XPW3@28889|Crenarchaeota	28889|Crenarchaeota	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA,Succ_CoA_lig
SX3_k127_3593638_0	880073.Calab_0674	2.014e-20	108.0	COG1520@1|root,COG2911@1|root,COG3420@1|root,COG1520@2|Bacteria,COG2911@2|Bacteria,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	4.2.2.3	ko:K01729,ko:K17713	ko00051,map00051	-	R03706	-	ko00000,ko00001,ko01000,ko02000	1.B.33.1	-	-	Beta_helix,Big_4,CHU_C,CarboxypepD_reg,DUF5050,HYR,Peptidase_S8,SprB
SX3_k127_3593882_5	1541065.JRFE01000004_gene5311	1.676e-30	127.0	COG1100@1|root,COG1100@2|Bacteria,1G5QQ@1117|Cyanobacteria,3VJTG@52604|Pleurocapsales	1117|Cyanobacteria	S	TIGRFAM small GTP-binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Ras,Roc
SX3_k127_3593882_1	192952.MM_2519	5.474e-101	334.0	COG1161@1|root,arCOG00350@2157|Archaea,2XWAE@28890|Euryarchaeota,2NA9B@224756|Methanomicrobia	224756|Methanomicrobia	S	Pfam:DUF258	-	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
SX3_k127_3593882_10	1121022.ABENE_19445	1.135e-10	68.0	COG0454@1|root,COG0454@2|Bacteria,1NHSU@1224|Proteobacteria	1224|Proteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10,Acetyltransf_7
SX3_k127_3593882_3	667632.KB890209_gene5323	5.077e-51	208.0	COG3210@1|root,COG3291@1|root,COG3210@2|Bacteria,COG3291@2|Bacteria,1MXIP@1224|Proteobacteria,2VJ6Y@28216|Betaproteobacteria,1K3NJ@119060|Burkholderiaceae	28216|Betaproteobacteria	U	family outer membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	ESPR,Glug,Haemagg_act
SX3_k127_3593882_12	1121451.DESAM_21810	0.0003142	52.0	COG3449@1|root,COG3449@2|Bacteria,1PG7N@1224|Proteobacteria,435WN@68525|delta/epsilon subdivisions,2X0CZ@28221|Deltaproteobacteria,2MBVA@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Bacterial transcription activator, effector binding domain	-	-	-	ko:K13652	-	-	-	-	ko00000,ko03000	-	-	-	GyrI-like
SX3_k127_3593882_11	1054217.TALC_00269	7.48e-06	52.0	arCOG06958@1|root,arCOG06958@2157|Archaea,2Y41U@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3593882_6	909663.KI867150_gene914	3.164e-21	98.0	COG3339@1|root,COG3339@2|Bacteria,1MZCY@1224|Proteobacteria,42V37@68525|delta/epsilon subdivisions,2WS08@28221|Deltaproteobacteria,2MQQK@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
SX3_k127_3593882_2	1121456.ATVA01000014_gene650	2.125e-53	192.0	COG3542@1|root,COG3542@2|Bacteria,1RHBE@1224|Proteobacteria,42T2P@68525|delta/epsilon subdivisions,2WPQ3@28221|Deltaproteobacteria,2MBSS@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Cupin superfamily (DUF985)	-	-	-	ko:K09705	-	-	-	-	ko00000	-	-	-	Cupin_5
SX3_k127_3593882_0	1499967.BAYZ01000115_gene2932	0.0	1026.0	COG0112@1|root,COG0404@1|root,COG0112@2|Bacteria,COG0404@2|Bacteria,2NP28@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	gcvT	GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008483,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0016769,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204	2.1.2.1,2.1.2.10,2.2.1.8	ko:K00600,ko:K00605,ko:K18847	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R01221,R02300,R04125,R09099	RC00022,RC00069,RC00112,RC00183,RC01583,RC02834,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C,SHMT
SX3_k127_3593882_4	439481.Aboo_0558	1.085e-50	188.0	arCOG13525@1|root,arCOG13525@2157|Archaea,2Y72N@28890|Euryarchaeota,3F3A7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3593882_8	880073.Calab_0825	1.366e-15	92.0	COG1404@1|root,COG3637@1|root,COG1404@2|Bacteria,COG3637@2|Bacteria,2NPDC@2323|unclassified Bacteria	2|Bacteria	O	Peptidase S8	-	-	3.4.21.66	ko:K08651	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	DUF3138,Peptidase_S8
SX3_k127_3593882_7	561230.PC1_0470	7.872e-18	99.0	COG0689@1|root,COG2931@1|root,COG3210@1|root,COG3637@1|root,COG0689@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3637@2|Bacteria,1MU7T@1224|Proteobacteria,1RSVF@1236|Gammaproteobacteria,1MRYX@122277|Pectobacterium	1236|Gammaproteobacteria	JMQU	Domain of unknown function (DUF4347)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347,He_PIG
SX3_k127_3593882_9	1379698.RBG1_1C00001G0584	1.755e-12	81.0	COG2373@1|root,COG2931@1|root,COG3209@1|root,COG3291@1|root,COG3386@1|root,COG2373@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,COG3291@2|Bacteria,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.4.24.40	ko:K01406,ko:K14274,ko:K20276,ko:K21449	ko00040,ko01503,ko02024,map00040,map01503,map02024	-	R02427	RC00713	ko00000,ko00001,ko01000,ko01002,ko02000	1.B.40.2	-	-	Calx-beta,DUF4347,He_PIG,Ice_nucleation,SGL
SX3_k127_3626254_10	877455.Metbo_0173	4.814e-52	187.0	COG0054@1|root,arCOG01323@2157|Archaea,2XXXC@28890|Euryarchaeota,23P08@183925|Methanobacteria	183925|Methanobacteria	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
SX3_k127_3626254_6	351160.LRC130	1.596e-80	276.0	COG4912@1|root,arCOG11010@2157|Archaea,2XWKG@28890|Euryarchaeota	28890|Euryarchaeota	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
SX3_k127_3626254_4	309799.DICTH_0189	4.793e-88	302.0	COG2461@1|root,COG2461@2|Bacteria	2|Bacteria	P	Hemerythrin HHE cation binding domain protein	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF438,Hemerythrin,PAS_10
SX3_k127_3626254_7	1121468.AUBR01000039_gene1942	1.624e-70	247.0	COG1773@1|root,COG1853@1|root,COG1773@2|Bacteria,COG1853@2|Bacteria,1VEQC@1239|Firmicutes,24QUV@186801|Clostridia,42GUB@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Rubredoxin-type Fe(Cys)4 protein	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct,Rubredoxin
SX3_k127_3626254_5	747365.Thena_0451	4.343e-85	288.0	COG1592@1|root,COG1592@2|Bacteria,1V1FF@1239|Firmicutes,248V2@186801|Clostridia,42GAI@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Rubrerythrin	rbr	GO:0003674,GO:0003824,GO:0004601,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0016692,GO:0022900,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
SX3_k127_3626254_11	768670.Calni_1127	4.317e-37	148.0	COG1392@1|root,COG1392@2|Bacteria	2|Bacteria	P	Protein of unknown function DUF47	MA20_27875	-	-	ko:K02039,ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
SX3_k127_3626254_2	1459636.NTE_00865	9.167e-93	318.0	COG0306@1|root,arCOG02267@2157|Archaea,41SD8@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Phosphate transporter family	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
SX3_k127_3626254_3	1459636.NTE_00865	5.631e-92	316.0	COG0306@1|root,arCOG02267@2157|Archaea,41SD8@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Phosphate transporter family	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
SX3_k127_3626254_1	1041930.Mtc_0757	1.806e-207	680.0	COG5016@1|root,arCOG02095@2157|Archaea,2XV3W@28890|Euryarchaeota,2N90X@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM oxaloacetate decarboxylase alpha subunit	pycB	-	6.4.1.1	ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1586	Biotin_lipoyl,HMGL-like,PYC_OADA
SX3_k127_3626254_15	1227453.C444_05011	4.581e-07	63.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWHT@28890|Euryarchaeota,23V64@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	gntR	-	-	-	-	-	-	-	-	-	-	-	HTH_24,HTH_5,MarR_2
SX3_k127_3626254_13	673860.AciM339_1412	1.803e-31	132.0	COG1386@1|root,arCOG02613@2157|Archaea,2XZ7Q@28890|Euryarchaeota,3F2S6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	TIGRFAM segregation and condensation protein B	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
SX3_k127_3626254_9	1054217.TALC_01156	4.319e-66	249.0	COG1549@1|root,arCOG00990@2157|Archaea,2XT9W@28890|Euryarchaeota,241NM@183967|Thermoplasmata	183967|Thermoplasmata	J	PUA domain	-	-	2.6.1.97	ko:K07557	-	-	-	-	ko00000,ko01000	-	-	-	PUA
SX3_k127_3626254_8	224325.AF_1012	2.882e-67	258.0	COG1244@1|root,arCOG01360@2157|Archaea,2XT5Q@28890|Euryarchaeota,245R5@183980|Archaeoglobi	183980|Archaeoglobi	S	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K06936	-	-	-	-	ko00000	-	-	-	Radical_SAM
SX3_k127_3626254_14	523845.AQXV01000044_gene1434	2.851e-09	69.0	COG2319@1|root,arCOG02491@2157|Archaea,2Y226@28890|Euryarchaeota	28890|Euryarchaeota	S	WD40 repeats	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,WD40
SX3_k127_3626254_12	868131.MSWAN_0153	5.8e-34	136.0	COG1720@1|root,arCOG00761@2157|Archaea,2XY3D@28890|Euryarchaeota,23PMX@183925|Methanobacteria	183925|Methanobacteria	S	PFAM Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
SX3_k127_3626254_0	56780.SYN_02218	0.0	1066.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
SX3_k127_3631691_0	1123508.JH636453_gene5802	1.883e-73	284.0	COG3210@1|root,COG3391@1|root,COG3827@1|root,COG4932@1|root,COG3210@2|Bacteria,COG3391@2|Bacteria,COG3827@2|Bacteria,COG4932@2|Bacteria,2IY8U@203682|Planctomycetes	203682|Planctomycetes	M	Integrin alpha (beta-propellor repeats).	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
SX3_k127_3631691_2	1521187.JPIM01000045_gene1423	5.936e-07	64.0	COG0739@1|root,COG3103@1|root,COG0739@2|Bacteria,COG4991@2|Bacteria,2G8N3@200795|Chloroflexi,3757D@32061|Chloroflexia	32061|Chloroflexia	MT	N-Acetylmuramoyl-L-alanine amidase	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3631691_1	926560.KE387023_gene1489	5.243e-11	78.0	COG3291@1|root,COG4676@1|root,COG3291@2|Bacteria,COG4676@2|Bacteria	2|Bacteria	UW	Protein conserved in bacteria	-	-	-	ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	CarboxypepD_reg,PKD,TPR_11,TPR_12,TPR_2,TPR_7,TPR_8
SX3_k127_3631691_3	273116.14325360	0.0001971	53.0	COG0467@1|root,arCOG01178@2157|Archaea,2Y0GM@28890|Euryarchaeota	28890|Euryarchaeota	T	PFAM GvpD gas vesicle	-	-	-	-	-	-	-	-	-	-	-	-	GvpD
SX3_k127_3635308_2	374847.Kcr_1508	5.971e-10	63.0	COG1400@1|root,arCOG01217@2157|Archaea	2157|Archaea	J	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP	srp19	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006605,GO:0006612,GO:0006613,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008312,GO:0015031,GO:0015833,GO:0033036,GO:0034613,GO:0042886,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0072657,GO:0090150,GO:0097159,GO:1901363	-	ko:K03105	ko03060,map03060	-	-	-	ko00000,ko00001,ko02044	3.A.5.7,3.A.5.9	-	-	SRP19
SX3_k127_3635308_1	673860.AciM339_1543	1.728e-41	156.0	COG2007@1|root,arCOG04154@2157|Archaea,2XYXX@28890|Euryarchaeota,3F2SE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Ribosomal protein S8e	rps8e	GO:0000462,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904	-	ko:K02995	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8e
SX3_k127_3635308_0	1232410.KI421428_gene1070	6.147e-44	170.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,42N67@68525|delta/epsilon subdivisions,2WPKC@28221|Deltaproteobacteria,43T9F@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	Bacitracin resistance protein BacA	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
SX3_k127_3639701_8	5346.XP_001830836.2	1.406e-08	64.0	KOG2437@1|root,KOG2437@2759|Eukaryota,3AG6F@33154|Opisthokonta,3PAX0@4751|Fungi,3V3D9@5204|Basidiomycota,22EZG@155619|Agaricomycetes	4751|Fungi	T	Muskelin N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4,Muskelin_N
SX3_k127_3639701_7	1121937.AUHJ01000028_gene930	2.081e-12	82.0	COG1372@1|root,COG1520@1|root,COG3209@1|root,COG1372@2|Bacteria,COG1520@2|Bacteria,COG3209@2|Bacteria,1QW4H@1224|Proteobacteria,1T42N@1236|Gammaproteobacteria,46DDZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	LM	Rhs Family	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,DUF5122,He_PIG,PT-HINT,RHS_repeat
SX3_k127_3639701_6	1120950.KB892756_gene6670	2.894e-18	101.0	COG3055@1|root,COG3055@2|Bacteria,2HC50@201174|Actinobacteria	201174|Actinobacteria	S	Kelch motif	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4
SX3_k127_3639701_0	224325.AF_0018	1.21e-138	452.0	COG0183@1|root,arCOG01278@2157|Archaea,2XVUA@28890|Euryarchaeota,2460R@183980|Archaeoglobi	183980|Archaeoglobi	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
SX3_k127_3639701_1	1122918.KB907249_gene3873	1.604e-130	451.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,4HA59@91061|Bacilli,26R8M@186822|Paenibacillaceae	91061|Bacilli	I	Dehydrogenase	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_2
SX3_k127_3639701_2	673860.AciM339_0595	1.735e-84	293.0	COG0006@1|root,arCOG01000@2157|Archaea,2XTI9@28890|Euryarchaeota,3F2JJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Belongs to the peptidase M24B family	pepQ1	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
SX3_k127_3639701_4	1041930.Mtc_1078	1.469e-39	162.0	COG0438@1|root,arCOG01410@2157|Archaea,2Y8CA@28890|Euryarchaeota,2NBP9@224756|Methanomicrobia	224756|Methanomicrobia	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SX3_k127_3639701_5	471852.Tcur_0080	1.255e-31	140.0	COG0438@1|root,COG0438@2|Bacteria,2GJ57@201174|Actinobacteria,4EHVT@85012|Streptosporangiales	201174|Actinobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SX3_k127_3639701_3	387631.Asulf_01560	1.806e-65	235.0	COG0013@1|root,arCOG01255@2157|Archaea,2XSXB@28890|Euryarchaeota,245ST@183980|Archaeoglobi	183980|Archaeoglobi	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0002161,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
SX3_k127_3639926_2	1521187.JPIM01000167_gene1704	6.225e-32	146.0	COG0457@1|root,COG1404@1|root,COG0457@2|Bacteria,COG1404@2|Bacteria,2G8UU@200795|Chloroflexi,3759F@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4,Kelch_5,Peptidase_S8
SX3_k127_3639926_5	660470.Theba_2263	2.515e-08	68.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	DUF1566,PQQ_2,PQQ_3
SX3_k127_3639926_6	744872.Spica_0581	3.239e-05	58.0	COG3291@1|root,COG3291@2|Bacteria,2J5PG@203691|Spirochaetes	203691|Spirochaetes	M	Protein conserved in bacteria	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	-
SX3_k127_3639926_4	414684.RC1_3822	9.822e-21	108.0	COG3898@1|root,COG3898@2|Bacteria,1R052@1224|Proteobacteria	1224|Proteobacteria	S	HemY domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3639926_0	572546.Arcpr_1325	1.878e-78	272.0	COG1234@1|root,arCOG00501@2157|Archaea,2XTJ9@28890|Euryarchaeota,245Q7@183980|Archaeoglobi	183980|Archaeoglobi	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
SX3_k127_3639926_1	673860.AciM339_0976	1.047e-34	144.0	COG1624@1|root,arCOG04453@2157|Archaea,2XTR1@28890|Euryarchaeota,3F2ZX@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a	dacZ	-	-	-	-	-	-	-	-	-	-	-	DisA_N
SX3_k127_3639926_3	1054217.TALC_00477	3.48e-30	129.0	COG4048@1|root,arCOG02103@1|root,arCOG02103@2157|Archaea,arCOG04902@2157|Archaea,2Y0TZ@28890|Euryarchaeota	28890|Euryarchaeota	S	Domain of unknown function (DUF4443)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2111,DUF4443
SX3_k127_3642487_10	439481.Aboo_0010	5.126e-11	77.0	COG1361@1|root,COG1572@1|root,arCOG01917@1|root,arCOG01917@2157|Archaea,arCOG02079@2157|Archaea,arCOG02532@2157|Archaea,2Y1TH@28890|Euryarchaeota,3F2UJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,DZR,zinc_ribbon_2
SX3_k127_3642487_8	673860.AciM339_1567	4.167e-18	91.0	COG1325@1|root,arCOG01042@2157|Archaea,2Y01Q@28890|Euryarchaeota,3F2VS@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	RNA binding	-	-	-	ko:K07581	-	-	-	-	ko00000	-	-	-	RNA_binding
SX3_k127_3642487_6	439481.Aboo_0646	1.094e-24	107.0	COG1522@1|root,arCOG01580@2157|Archaea,2Y746@28890|Euryarchaeota,3F3D8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
SX3_k127_3642487_0	1459636.NTE_00642	6.947e-104	344.0	COG0005@1|root,arCOG01327@2157|Archaea,41SDR@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
SX3_k127_3642487_1	673860.AciM339_0169	2.388e-75	259.0	COG2236@1|root,arCOG00040@2157|Archaea,2XU0E@28890|Euryarchaeota,3F38W@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Phosphoribosyl transferase domain	-	-	2.4.2.22	ko:K00769,ko:K07101	ko00230,ko01100,ko01110,map00230,map01100,map01110	-	R01229,R02142	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
SX3_k127_3642487_4	192952.MM_3074	1.152e-38	159.0	COG2042@1|root,arCOG04733@2157|Archaea,2XVBD@28890|Euryarchaeota,2N9PH@224756|Methanomicrobia	224756|Methanomicrobia	J	pre-rRNA processing protein involved in ribosome biogenesis	-	-	-	ko:K09140	-	-	-	-	ko00000,ko03009	-	-	-	RLI,Ribo_biogen_C
SX3_k127_3642487_9	351160.RCIX1433	2.595e-13	70.0	COG1552@1|root,arCOG04049@2157|Archaea,2Y177@28890|Euryarchaeota,2NB9F@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eL40 family	rpl40e	-	-	ko:K02927	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L40e
SX3_k127_3642487_7	304371.MCP_2599	2.269e-20	95.0	COG3388@1|root,arCOG01345@2157|Archaea,2XXVY@28890|Euryarchaeota,2N9YC@224756|Methanomicrobia	224756|Methanomicrobia	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3642487_2	717606.PaecuDRAFT_2136	3.2e-45	191.0	COG1520@1|root,COG3210@1|root,COG4412@1|root,COG5276@1|root,COG5492@1|root,COG1520@2|Bacteria,COG3210@2|Bacteria,COG4412@2|Bacteria,COG5276@2|Bacteria,COG5492@2|Bacteria,1TR9M@1239|Firmicutes,4HEPP@91061|Bacilli,26T62@186822|Paenibacillaceae	91061|Bacilli	U	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Cadherin-like,Cohesin,Invasin_D3,SLH
SX3_k127_3642487_5	1165841.SULAR_04778	3.147e-26	128.0	COG1520@1|root,COG4676@1|root,COG1520@2|Bacteria,COG4676@2|Bacteria	2|Bacteria	UW	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,PQQ,PQQ_2,UPF0560
SX3_k127_3642487_11	471854.Dfer_1756	5.346e-10	74.0	COG1749@1|root,COG3386@1|root,COG1749@2|Bacteria,COG3386@2|Bacteria,4NTUT@976|Bacteroidetes	976|Bacteroidetes	N	Domain of unknown function (DUF4082)	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE,DUF4082
SX3_k127_3642487_3	717606.PaecuDRAFT_2136	1.024e-40	174.0	COG1520@1|root,COG3210@1|root,COG4412@1|root,COG5276@1|root,COG5492@1|root,COG1520@2|Bacteria,COG3210@2|Bacteria,COG4412@2|Bacteria,COG5276@2|Bacteria,COG5492@2|Bacteria,1TR9M@1239|Firmicutes,4HEPP@91061|Bacilli,26T62@186822|Paenibacillaceae	91061|Bacilli	U	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Cadherin-like,Cohesin,Invasin_D3,SLH
SX3_k127_366588_2	314271.RB2654_06724	9.498e-55	210.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase,Cadherin,FG-GAP,Glyco_hydro_26,HemolysinCabind,Integrin_beta,Lipase_GDSL_2
SX3_k127_366588_1	439481.Aboo_0834	1.088e-57	209.0	COG1056@1|root,arCOG00972@2157|Archaea,2XUF7@28890|Euryarchaeota,3F2N0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Cytidylyltransferase-like	nadM	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.7.1	ko:K00952	ko00760,ko01100,map00760,map01100	-	R00137,R03005	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
SX3_k127_366588_0	673860.AciM339_1547	1.806e-252	795.0	COG0466@1|root,arCOG02160@2157|Archaea,2XTT0@28890|Euryarchaeota,3F2HW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Belongs to the peptidase S16 family	lon	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C,Mg_chelatase
SX3_k127_3710246_1	693661.Arcve_0149	3.737e-05	50.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,246Q2@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator, ArsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
SX3_k127_3710246_0	1047013.AQSP01000023_gene934	6.28e-120	400.0	COG0624@1|root,COG0624@2|Bacteria,2NQ4M@2323|unclassified Bacteria	2|Bacteria	E	Peptidase family M20/M25/M40	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
SX3_k127_3756033_1	483219.LILAB_25790	2.745e-11	78.0	COG4412@1|root,COG4412@2|Bacteria,1R3SG@1224|Proteobacteria,42SZZ@68525|delta/epsilon subdivisions,2WPD0@28221|Deltaproteobacteria,2YUKS@29|Myxococcales	28221|Deltaproteobacteria	E	Fungalysin metallopeptidase (M36)	-	-	-	-	-	-	-	-	-	-	-	-	FTP,PA,Peptidase_M36,Peptidase_M6
SX3_k127_3756033_2	1268239.PALB_34890	1.266e-06	63.0	COG2911@1|root,COG3291@1|root,COG2911@2|Bacteria,COG3291@2|Bacteria,1QYAF@1224|Proteobacteria,1T3N4@1236|Gammaproteobacteria,2Q5KT@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	Metallo-peptidase family M12B Reprolysin-like	-	-	-	-	-	-	-	-	-	-	-	-	Reprolysin_4
SX3_k127_3756033_0	880073.Calab_0825	5.112e-22	113.0	COG1404@1|root,COG3637@1|root,COG1404@2|Bacteria,COG3637@2|Bacteria,2NPDC@2323|unclassified Bacteria	2|Bacteria	O	Peptidase S8	-	-	3.4.21.66	ko:K08651	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	DUF3138,Peptidase_S8
SX3_k127_3762885_10	1297742.A176_05132	4.15e-26	126.0	COG2885@1|root,COG2885@2|Bacteria,1MX1F@1224|Proteobacteria,42UTB@68525|delta/epsilon subdivisions,2WQUW@28221|Deltaproteobacteria,2YUE1@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,DUF11,OmpA,Phenol_MetA_deg,TSP_3
SX3_k127_3762885_13	111781.Lepto7376_3756	2.376e-10	75.0	COG1572@1|root,COG3209@1|root,COG3210@1|root,COG1572@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	CARDB,RHS_repeat
SX3_k127_3762885_11	1463857.JOFZ01000015_gene924	4.43e-25	123.0	COG3291@1|root,COG3386@1|root,COG3291@2|Bacteria,COG3386@2|Bacteria,2GNGF@201174|Actinobacteria	201174|Actinobacteria	G	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Copper-bind,DUF1080
SX3_k127_3762885_5	1408473.JHXO01000005_gene1726	4.113e-80	280.0	COG2818@1|root,COG2818@2|Bacteria,4NGRC@976|Bacteroidetes,2FN7E@200643|Bacteroidia	976|Bacteroidetes	L	DNA-3-methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
SX3_k127_3762885_1	697303.Thewi_2349	9.489e-106	357.0	COG1063@1|root,COG1063@2|Bacteria,1TS6I@1239|Firmicutes,25B0S@186801|Clostridia,42JE5@68295|Thermoanaerobacterales	186801|Clostridia	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
SX3_k127_3762885_0	374847.Kcr_0632	1.892e-127	418.0	COG0156@1|root,arCOG00113@2157|Archaea	2157|Archaea	E	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	-	2.3.1.29,2.3.1.47,4.1.2.48	ko:K00639,ko:K00652,ko:K01620	ko00260,ko00780,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00780,map01100,map01110,map01120,map01130,map01230	M00123,M00573,M00577	R00371,R00751,R03210,R06171,R10124	RC00004,RC00039,RC00312,RC00372,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
SX3_k127_3762885_2	521011.Mpal_0661	7.519e-96	329.0	COG3199@1|root,arCOG01350@2157|Archaea,2XUIQ@28890|Euryarchaeota	28890|Euryarchaeota	S	ATP-NAD AcoX kinase	-	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
SX3_k127_3762885_7	515635.Dtur_0526	5.91e-47	174.0	COG0394@1|root,COG0394@2|Bacteria	2|Bacteria	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	arsC	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008794,GO:0016491,GO:0030611,GO:0030613,GO:0030614,GO:0042221,GO:0046685,GO:0050896,GO:0055114	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
SX3_k127_3762885_9	469378.Ccur_09250	3.875e-40	158.0	COG1351@1|root,COG1351@2|Bacteria,2HCNJ@201174|Actinobacteria,4CV8N@84998|Coriobacteriia	84998|Coriobacteriia	H	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
SX3_k127_3762885_4	309801.trd_0272	1.316e-84	286.0	COG1136@1|root,COG1136@2|Bacteria,2G6B5@200795|Chloroflexi,27YCE@189775|Thermomicrobia	189775|Thermomicrobia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_3762885_3	479434.Sthe_1776	2.184e-90	335.0	COG0577@1|root,COG3127@1|root,COG0577@2|Bacteria,COG3127@2|Bacteria,2G6CK@200795|Chloroflexi,27Z42@189775|Thermomicrobia	189775|Thermomicrobia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
SX3_k127_3762885_12	1163409.UUA_06754	2.59e-19	92.0	COG1695@1|root,COG1695@2|Bacteria,1NJSY@1224|Proteobacteria,1SG6R@1236|Gammaproteobacteria,1X6UG@135614|Xanthomonadales	135614|Xanthomonadales	K	PadR family transcriptional regulator	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
SX3_k127_3762885_6	439481.Aboo_0161	1.797e-49	190.0	COG1402@1|root,arCOG04536@2157|Archaea,2XTQE@28890|Euryarchaeota,3F335@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
SX3_k127_3762885_8	673860.AciM339_0523	4.305e-44	164.0	COG0463@1|root,arCOG00894@2157|Archaea,2XUJ6@28890|Euryarchaeota,3F38U@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SX3_k127_377358_1	880071.Fleli_2410	1.249e-24	122.0	COG5492@1|root,COG5492@2|Bacteria,4PAER@976|Bacteroidetes,47TE8@768503|Cytophagia	976|Bacteroidetes	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_377358_2	222534.KB893670_gene3882	2.86e-24	121.0	COG3507@1|root,COG3507@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Glyco_hyd_101C,Glyco_hydro_101,Glyco_hydro_43,NPCBM,NPCBM_assoc,RicinB_lectin_2
SX3_k127_377358_0	1408473.JHXO01000015_gene1906	5.209e-44	179.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	nanA	GO:0001573,GO:0003674,GO:0003824,GO:0004308,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006672,GO:0006687,GO:0006689,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0016020,GO:0016042,GO:0016052,GO:0016787,GO:0016798,GO:0016997,GO:0019377,GO:0030149,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044424,GO:0044464,GO:0046466,GO:0046479,GO:0046514,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1903509	3.2.1.18	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	-	R04018	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33	-	BNR_2,Gram_pos_anchor,Sialidase,YSIRK_signal
SX3_k127_3795786_4	273068.TTE0824	7.627e-50	205.0	COG1404@1|root,COG1404@2|Bacteria,1TQRU@1239|Firmicutes,249H1@186801|Clostridia,42FS7@68295|Thermoanaerobacterales	186801|Clostridia	M	Serine protease with a broad substrate specificity	-	-	-	ko:K13276,ko:K17734	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	CarboxypepD_reg,Cu_amine_oxidN1,Inhibitor_I9,LRR_5,PPC,Peptidase_S8
SX3_k127_3795786_8	1448860.BBJO01000002_gene2054	2.808e-09	72.0	COG3291@1|root,arCOG02483@1|root,arCOG02483@2157|Archaea,arCOG02546@2157|Archaea,2Y7ZF@28890|Euryarchaeota,24143@183963|Halobacteria	183963|Halobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
SX3_k127_3795786_7	273116.14325471	7.583e-20	102.0	arCOG03142@1|root,arCOG03142@2157|Archaea,2XTSE@28890|Euryarchaeota,24268@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3795786_3	459349.CLOAM0313	4.204e-70	271.0	COG1305@1|root,COG1305@2|Bacteria	2|Bacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_1,DUF3857,GBS_Bsp-like,Transglut_core
SX3_k127_3795786_6	404380.Gbem_1798	3.162e-20	108.0	COG1404@1|root,COG4932@1|root,COG1404@2|Bacteria,COG4932@2|Bacteria,1MU3S@1224|Proteobacteria	1224|Proteobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Big_3_3,fn3
SX3_k127_3795786_0	1365176.N186_02525	1.006e-276	869.0	COG0464@1|root,arCOG01308@2157|Archaea,2XPPI@28889|Crenarchaeota	28889|Crenarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
SX3_k127_3795786_5	673860.AciM339_1207	1.042e-26	111.0	COG1873@1|root,arCOG02155@2157|Archaea,2Y75G@28890|Euryarchaeota,3F3FD@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
SX3_k127_3795786_1	868595.Desca_2480	1.347e-128	426.0	COG0531@1|root,COG0531@2|Bacteria,1TQ4K@1239|Firmicutes,25E7A@186801|Clostridia,262ZX@186807|Peptococcaceae	186801|Clostridia	E	PFAM Amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2,AA_permease_C
SX3_k127_3795786_2	1249627.D779_3143	2.745e-82	303.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,1RZ6G@1236|Gammaproteobacteria,1X1H2@135613|Chromatiales	135613|Chromatiales	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
SX3_k127_3822841_0	1121422.AUMW01000028_gene3417	7.322e-176	558.0	COG0426@1|root,COG0426@2|Bacteria,1TQE9@1239|Firmicutes,249CU@186801|Clostridia,2619Q@186807|Peptococcaceae	186801|Clostridia	C	PFAM Flavodoxin	-	-	1.6.3.4	ko:K22405	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_1,Lactamase_B
SX3_k127_3822841_9	304371.MCP_2757	7.025e-20	90.0	COG1773@1|root,arCOG04391@2157|Archaea,2Y5RW@28890|Euryarchaeota,2NBCH@224756|Methanomicrobia	224756|Methanomicrobia	C	Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule	-	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
SX3_k127_3822841_7	706587.Desti_0011	6.338e-50	196.0	COG1014@1|root,COG1014@2|Bacteria,1R8XG@1224|Proteobacteria,42NPD@68525|delta/epsilon subdivisions,2WMQ1@28221|Deltaproteobacteria,2MRSP@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
SX3_k127_3822841_4	706587.Desti_0012	3.085e-104	351.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,42MD3@68525|delta/epsilon subdivisions,2WJQ0@28221|Deltaproteobacteria,2MR5W@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	ferredoxin oxidoreductase beta subunit	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
SX3_k127_3822841_1	706587.Desti_0013	4.616e-156	507.0	COG0674@1|root,COG0674@2|Bacteria,1NBSJ@1224|Proteobacteria,42MS1@68525|delta/epsilon subdivisions,2WJ97@28221|Deltaproteobacteria,2MRFE@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	ferredoxin oxidoreductase, alpha subunit	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
SX3_k127_3822841_8	335543.Sfum_0018	3.336e-30	123.0	COG1146@1|root,COG1146@2|Bacteria,1N0QV@1224|Proteobacteria,42U2Z@68525|delta/epsilon subdivisions,2WR58@28221|Deltaproteobacteria,2MS46@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7
SX3_k127_3822841_3	1054217.TALC_00175	2.562e-124	410.0	COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,241M6@183967|Thermoplasmata	183967|Thermoplasmata	E	Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
SX3_k127_3822841_2	439481.Aboo_0457	1.333e-153	496.0	COG0269@1|root,arCOG00053@2157|Archaea,2XV47@28890|Euryarchaeota,3F2IP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	Aldolase/RraA	-	-	4.1.2.43,5.3.1.27	ko:K13831	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05338,R05339,R09780	RC00377,RC00421,RC00422	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase,RraA-like
SX3_k127_3822841_11	1120950.KB892754_gene6015	4.43e-16	83.0	COG4747@1|root,COG4747@2|Bacteria,2GZWK@201174|Actinobacteria	201174|Actinobacteria	S	ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3822841_10	696747.NIES39_A03070	2.318e-19	99.0	COG0730@1|root,COG0730@2|Bacteria,1G0VP@1117|Cyanobacteria,1H7V5@1150|Oscillatoriales	1117|Cyanobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
SX3_k127_3822841_12	1138822.PL11_06905	0.0005764	50.0	arCOG05209@1|root,31PIN@2|Bacteria,1V5G2@1239|Firmicutes,4HIRV@91061|Bacilli,3F6X9@33958|Lactobacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3822841_6	529709.PYCH_00880	2.148e-60	224.0	COG1867@1|root,arCOG01219@2157|Archaea,2XTUF@28890|Euryarchaeota,243GQ@183968|Thermococci	183968|Thermococci	J	Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups	trm1	GO:0001510,GO:0002940,GO:0003674,GO:0003824,GO:0004809,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.215,2.1.1.216	ko:K00555	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TRM
SX3_k127_3822841_5	673860.AciM339_0768	1.078e-64	226.0	COG1618@1|root,arCOG01034@2157|Archaea,2XX6U@28890|Euryarchaeota,3F2MF@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency	-	-	3.6.1.15	ko:K06928	ko00230,ko00730,ko01100,map00230,map00730,map01100	-	R00086,R00615	RC00002	ko00000,ko00001,ko01000	-	-	-	NTPase_1
SX3_k127_3847679_0	70601.3258323	9.427e-63	222.0	COG0149@1|root,arCOG01087@2157|Archaea,2XTY3@28890|Euryarchaeota,24332@183968|Thermococci	183968|Thermococci	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM,ThiG
SX3_k127_3847679_2	926550.CLDAP_33710	4.82e-24	120.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
SX3_k127_3847679_3	1131462.DCF50_p2674	1.008e-11	79.0	COG1404@1|root,COG4733@1|root,COG1404@2|Bacteria,COG4733@2|Bacteria,1VIJH@1239|Firmicutes	1239|Firmicutes	N	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3847679_4	1521187.JPIM01000045_gene1423	5.499e-06	61.0	COG0739@1|root,COG3103@1|root,COG0739@2|Bacteria,COG4991@2|Bacteria,2G8N3@200795|Chloroflexi,3757D@32061|Chloroflexia	32061|Chloroflexia	MT	N-Acetylmuramoyl-L-alanine amidase	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3847679_1	880071.Fleli_2410	2.205e-26	125.0	COG5492@1|root,COG5492@2|Bacteria,4PAER@976|Bacteroidetes,47TE8@768503|Cytophagia	976|Bacteroidetes	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3877669_3	1157637.KB892100_gene2356	9.738e-07	63.0	COG3055@1|root,COG4934@1|root,COG3055@2|Bacteria,COG4934@2|Bacteria,2IF2T@201174|Actinobacteria	201174|Actinobacteria	O	Kelch motif	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Kelch_1
SX3_k127_3877669_2	479431.Namu_4457	1.454e-27	132.0	COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4ETCD@85013|Frankiales	201174|Actinobacteria	S	Laminin G domain	wcoG	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PKD
SX3_k127_3877669_1	415426.Hbut_0338	6.925e-33	138.0	COG0237@1|root,arCOG01045@2157|Archaea,2XQTJ@28889|Crenarchaeota	28889|Crenarchaeota	F	Belongs to the UPF0200 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_17,AAA_18
SX3_k127_3877669_0	1123075.AUDP01000051_gene101	1.308e-37	159.0	COG3875@1|root,COG3875@2|Bacteria,1TQ1C@1239|Firmicutes,247PH@186801|Clostridia,3WHY8@541000|Ruminococcaceae	186801|Clostridia	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
SX3_k127_388955_2	192952.MM_2298	1.03e-123	417.0	COG4962@1|root,arCOG01818@2157|Archaea,2XTN5@28890|Euryarchaeota,2N9AG@224756|Methanomicrobia	224756|Methanomicrobia	N	Type II/IV secretion system protein	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE
SX3_k127_388955_3	1094980.Mpsy_1105	3.516e-88	314.0	arCOG01814@1|root,arCOG01814@2157|Archaea,2XT74@28890|Euryarchaeota,2N90N@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_388955_0	565033.GACE_2079	7.759e-263	836.0	arCOG02763@1|root,arCOG02763@2157|Archaea,2Y8CF@28890|Euryarchaeota,247IC@183980|Archaeoglobi	183980|Archaeoglobi	P	Heavy-metal-associated domain	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
SX3_k127_388955_1	351160.RCIX1438	7.33e-137	446.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,2N9G1@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM transferase hexapeptide repeat containing protein	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transferase
SX3_k127_388955_4	224325.AF_1728	8.992e-56	209.0	COG0438@1|root,arCOG01403@2157|Archaea,2XVAJ@28890|Euryarchaeota,245P8@183980|Archaeoglobi	183980|Archaeoglobi	M	Glycosyltransferase Family 4	-	-	2.4.1.87	ko:K00743	ko00601,map00601	-	R05978,R06169	-	ko00000,ko00001,ko01000,ko01003	-	GT6	-	Glyco_transf_4,Glycos_transf_1
SX3_k127_388955_7	192952.MM_2604	2.996e-09	62.0	arCOG10361@1|root,arCOG10361@2157|Archaea,2Y5Z6@28890|Euryarchaeota,2NBEF@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_388955_6	192952.MM_2605	4.075e-11	66.0	COG2026@1|root,arCOG01665@2157|Archaea	2157|Archaea	DJ	PFAM plasmid stabilization system	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
SX3_k127_388955_5	565033.GACE_0788	9.427e-32	129.0	COG1924@1|root,arCOG02678@2157|Archaea,2XVMQ@28890|Euryarchaeota,245WU@183980|Archaeoglobi	183980|Archaeoglobi	I	BadF/BadG/BcrA/BcrD ATPase family	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
SX3_k127_3901553_12	673860.AciM339_0955	7.987e-42	163.0	COG0613@1|root,arCOG00302@2157|Archaea,2XSWE@28890|Euryarchaeota,3F2NI@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	DNA polymerase alpha chain like domain	-	-	-	-	-	-	-	-	-	-	-	-	PHP,PHP_C
SX3_k127_3901553_0	673860.AciM339_0956	5.915e-220	709.0	COG0143@1|root,arCOG00810@2157|Archaea,2XTG5@28890|Euryarchaeota,3F2F7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A0543	Anticodon_1,tRNA-synt_1g,tRNA_bind
SX3_k127_3901553_14	326427.Cagg_1904	1.087e-34	143.0	COG0500@1|root,COG2226@2|Bacteria,2G6N8@200795|Chloroflexi,375GC@32061|Chloroflexia	32061|Chloroflexia	Q	Methyltransferase type 12	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
SX3_k127_3901553_7	456442.Mboo_2448	2.954e-69	246.0	COG3276@1|root,arCOG01564@2157|Archaea,2XWBV@28890|Euryarchaeota,2N945@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM elongation factor Tu domain 2	-	-	-	-	-	-	-	-	-	-	-	-	GTP_EFTU_D2
SX3_k127_3901553_1	1259795.ARJK01000003_gene1200	1.82e-191	612.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1TSSC@1239|Firmicutes,248I6@186801|Clostridia,42FHQ@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Pyruvate flavodoxin ferredoxin oxidoreductase	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
SX3_k127_3901553_5	1259795.ARJK01000003_gene1201	1.312e-105	349.0	COG1013@1|root,COG1013@2|Bacteria,1TQJ2@1239|Firmicutes,25CAJ@186801|Clostridia,42FZW@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM 2-oxoacid acceptor oxidoreductase, beta subunit, pyruvate 2-ketoisovalerate	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
SX3_k127_3901553_3	459349.CLOAM0150	3.48e-158	505.0	COG0863@1|root,COG0863@2|Bacteria,2NP0K@2323|unclassified Bacteria	2|Bacteria	L	DNA methylase	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
SX3_k127_3901553_11	1054217.TALC_00017	1.413e-50	188.0	COG1082@1|root,arCOG01895@2157|Archaea,2XUTU@28890|Euryarchaeota	28890|Euryarchaeota	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SX3_k127_3901553_15	572546.Arcpr_0336	1.223e-16	86.0	COG0237@1|root,arCOG01045@2157|Archaea,2XWNJ@28890|Euryarchaeota,245NW@183980|Archaeoglobi	183980|Archaeoglobi	H	Belongs to the UPF0200 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_17,RNA_binding
SX3_k127_3901553_9	1430331.EP10_06835	3.139e-58	216.0	COG0006@1|root,COG0006@2|Bacteria,1TQ44@1239|Firmicutes,4HAT7@91061|Bacilli,1WEYN@129337|Geobacillus	91061|Bacilli	E	Creatinase/Prolidase N-terminal domain	yqhT	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
SX3_k127_3901553_4	439481.Aboo_0578	8.219e-122	407.0	COG0644@1|root,arCOG00570@2157|Archaea,2XU3J@28890|Euryarchaeota,3F2EW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	bchP	-	1.3.1.101,1.3.7.11,1.5.5.1	ko:K00311,ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2,FAD_binding_3,FAD_oxidored,Lycopene_cycl,Trp_halogenase
SX3_k127_3901553_16	1236689.MMALV_03580	1.792e-10	72.0	arCOG02449@1|root,arCOG02449@2157|Archaea	2157|Archaea	-	-	-	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_10,Flavodoxin_3
SX3_k127_3901553_8	439481.Aboo_1535	2.117e-61	220.0	COG1378@1|root,arCOG02038@2157|Archaea,2Y7FZ@28890|Euryarchaeota,3F2ZR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Archaeal transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
SX3_k127_3901553_6	439481.Aboo_0894	2.522e-71	260.0	COG1986@1|root,arCOG01221@2157|Archaea,arCOG01223@2157|Archaea,2XWGY@28890|Euryarchaeota,3F2ZA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions	coaD	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K02201	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
SX3_k127_3901553_17	1236689.MMALV_07850	1.123e-05	50.0	COG4068@1|root,arCOG04390@2157|Archaea,2Y639@28890|Euryarchaeota	28890|Euryarchaeota	S	Uncharacterized protein containing a Zn-ribbon (DUF2116)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2116
SX3_k127_3901553_13	383372.Rcas_3603	2.372e-37	149.0	COG1100@1|root,COG1100@2|Bacteria,2G9IC@200795|Chloroflexi,3777W@32061|Chloroflexia	32061|Chloroflexia	S	SMART Ras small GTPase, Ras type	-	-	-	-	-	-	-	-	-	-	-	-	Ras
SX3_k127_3901553_10	1094980.Mpsy_1848	1.678e-55	200.0	arCOG03571@1|root,arCOG03571@2157|Archaea,2Y1FB@28890|Euryarchaeota,2NAR3@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
SX3_k127_3901553_2	335543.Sfum_3244	3.071e-186	590.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NM8@68525|delta/epsilon subdivisions,2WIWB@28221|Deltaproteobacteria,2MRBG@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
SX3_k127_3913681_7	679926.Mpet_1013	1.032e-21	96.0	COG4826@1|root,arCOG04933@2157|Archaea,2XV8M@28890|Euryarchaeota,2NA7C@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM proteinase inhibitor I4 serpin	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
SX3_k127_3913681_9	1236689.MMALV_14270	1.353e-13	78.0	COG4004@1|root,arCOG04412@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3913681_10	673860.AciM339_0379	1.084e-05	52.0	arCOG06415@1|root,arCOG06415@2157|Archaea	2157|Archaea	L	Ribosomal protein S1-like RNA-binding domain	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	zf-HIT
SX3_k127_3913681_4	397278.JOJN01000012_gene2205	1.85e-48	192.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	remC	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_2,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
SX3_k127_3913681_1	203119.Cthe_1309	3.45e-90	308.0	COG0535@1|root,COG0535@2|Bacteria,1TR85@1239|Firmicutes,249NQ@186801|Clostridia,3WJKC@541000|Ruminococcaceae	186801|Clostridia	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
SX3_k127_3913681_8	1236689.MMALV_14370	5.292e-19	93.0	arCOG03042@1|root,arCOG03042@2157|Archaea,2Y2X3@28890|Euryarchaeota	28890|Euryarchaeota	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3913681_6	439481.Aboo_0327	2.656e-38	168.0	COG4934@1|root,arCOG05978@1|root,arCOG03669@2157|Archaea,arCOG05978@2157|Archaea,2Y7X2@28890|Euryarchaeota,3F38G@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	Pro-kuma_activ,fn3
SX3_k127_3913681_5	1183438.GKIL_3263	2.306e-48	201.0	COG1470@1|root,COG3391@1|root,COG1470@2|Bacteria,COG3391@2|Bacteria,1G0EB@1117|Cyanobacteria	1117|Cyanobacteria	DZ	PFAM Na-Ca exchanger integrin-beta4 peptidase-like FG-GAP	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Calx-beta,DUF4347,He_PIG,HemolysinCabind,PPC,VCBS
SX3_k127_3913681_0	673860.AciM339_0863	7.65e-150	490.0	COG0016@1|root,arCOG00410@2157|Archaea,2XSTK@28890|Euryarchaeota,3F2II@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
SX3_k127_3913681_3	391623.TERMP_01507	4.678e-68	249.0	COG1668@1|root,arCOG01462@2157|Archaea,2XXQM@28890|Euryarchaeota,245BX@183968|Thermococci	183968|Thermococci	C	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
SX3_k127_3913681_2	523850.TON_1348	8.61e-80	275.0	COG1131@1|root,arCOG00194@2157|Archaea,2XWV8@28890|Euryarchaeota,242K1@183968|Thermococci	183968|Thermococci	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_3922812_0	1284352.AOIG01000013_gene3550	7.049e-35	154.0	COG0457@1|root,COG3210@1|root,COG5492@1|root,COG0457@2|Bacteria,COG3210@2|Bacteria,COG5492@2|Bacteria,1TR9M@1239|Firmicutes,4HEPP@91061|Bacilli,26T62@186822|Paenibacillaceae	91061|Bacilli	U	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Cadherin-like,Cohesin,Invasin_D3,SLH
SX3_k127_3922812_2	195250.CM001776_gene1220	2.095e-16	94.0	COG2304@1|root,COG3209@1|root,COG2304@2|Bacteria,COG3209@2|Bacteria,1GJ0D@1117|Cyanobacteria,1H29D@1129|Synechococcus	1117|Cyanobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,RHS_repeat,SdrD_B
SX3_k127_3922812_1	717606.PaecuDRAFT_2136	2.503e-31	139.0	COG1520@1|root,COG3210@1|root,COG4412@1|root,COG5276@1|root,COG5492@1|root,COG1520@2|Bacteria,COG3210@2|Bacteria,COG4412@2|Bacteria,COG5276@2|Bacteria,COG5492@2|Bacteria,1TR9M@1239|Firmicutes,4HEPP@91061|Bacilli,26T62@186822|Paenibacillaceae	91061|Bacilli	U	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Cadherin-like,Cohesin,Invasin_D3,SLH
SX3_k127_3927046_0	935948.KE386494_gene960	2.835e-77	266.0	COG1606@1|root,COG1606@2|Bacteria,1TPB2@1239|Firmicutes,2485J@186801|Clostridia,42FCT@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM PP-loop domain protein	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	ATP_bind_3,NAD_synthase,QueC
SX3_k127_3927046_1	1094980.Mpsy_0983	3.87e-58	221.0	COG1404@1|root,arCOG02538@1|root,arCOG03439@1|root,arCOG00702@2157|Archaea,arCOG02538@2157|Archaea,arCOG03439@2157|Archaea,2XTGN@28890|Euryarchaeota,2N9WH@224756|Methanomicrobia	224756|Methanomicrobia	O	Subtilase family	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Calx-beta,Inhibitor_I9,Peptidase_S8
SX3_k127_3965691_0	439481.Aboo_1178	1.69e-306	957.0	COG0525@1|root,arCOG00808@2157|Archaea,2XSXQ@28890|Euryarchaeota,3F2GU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Anticodon-binding domain of tRNA	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A1976	Anticodon_1,tRNA-synt_1
SX3_k127_3965691_6	768710.DesyoDRAFT_0766	1.152e-45	177.0	COG0491@1|root,COG0491@2|Bacteria,1V62I@1239|Firmicutes,24I5E@186801|Clostridia,261TE@186807|Peptococcaceae	186801|Clostridia	S	Zn-dependent hydrolase, glyoxylase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SX3_k127_3965691_9	662479.C440_01030	2.593e-24	117.0	COG0438@1|root,arCOG06114@2157|Archaea,2XW7X@28890|Euryarchaeota,23UY4@183963|Halobacteria	183963|Halobacteria	M	COG0438 Glycosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
SX3_k127_3965691_10	468059.AUHA01000003_gene1802	4.374e-23	114.0	COG1216@1|root,COG1216@2|Bacteria,4NFP0@976|Bacteroidetes,1IP9Q@117747|Sphingobacteriia	976|Bacteroidetes	H	glycosyl transferase family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
SX3_k127_3965691_11	1408424.JHYI01000011_gene1367	1.712e-17	94.0	COG0454@1|root,COG0456@2|Bacteria,1V4GU@1239|Firmicutes,4HKA1@91061|Bacilli	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SX3_k127_3965691_7	340177.Cag_0025	1.406e-38	151.0	COG1970@1|root,COG1970@2|Bacteria,1FF5D@1090|Chlorobi	1090|Chlorobi	C	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
SX3_k127_3965691_12	768679.TTX_1675	8.204e-17	83.0	COG1911@1|root,arCOG01752@2157|Archaea,2XR8J@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL30 family	rpl30e	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02908	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L7Ae
SX3_k127_3965691_8	192952.MM_2268	1.367e-29	127.0	COG0195@1|root,arCOG01760@2157|Archaea,2XYAY@28890|Euryarchaeota,2N9SC@224756|Methanomicrobia	224756|Methanomicrobia	K	transcription termination protein NusA	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_2
SX3_k127_3965691_2	316274.Haur_3988	1.449e-90	309.0	COG1703@1|root,COG1703@2|Bacteria,2G670@200795|Chloroflexi,3751X@32061|Chloroflexia	32061|Chloroflexia	E	TIGRFAM LAO AO transport system ATPase	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
SX3_k127_3965691_4	1121468.AUBR01000005_gene80	1.16e-58	206.0	COG2185@1|root,COG2185@2|Bacteria,1V3QN@1239|Firmicutes,24HAR@186801|Clostridia,42GHH@68295|Thermoanaerobacterales	186801|Clostridia	I	methylmalonyl-CoA mutase C-terminal	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
SX3_k127_3965691_5	1236689.MMALV_10880	5.067e-53	203.0	COG0402@1|root,arCOG00692@2157|Archaea,2XSYB@28890|Euryarchaeota,3F2N3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Amidohydrolase family	guaD2	-	3.5.4.1,3.5.4.3	ko:K01485,ko:K01487	ko00230,ko00240,ko00330,ko01100,map00230,map00240,map00330,map01100	-	R00974,R01411,R01676,R02922	RC00074,RC00204,RC00514,RC00809	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
SX3_k127_3965691_3	1041930.Mtc_0280	1.816e-66	239.0	COG0517@1|root,arCOG00600@2157|Archaea,2XU4J@28890|Euryarchaeota,2N994@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SX3_k127_3965691_1	304371.MCP_0148	9.578e-182	586.0	COG0423@1|root,arCOG00405@2157|Archaea,2XSZK@28890|Euryarchaeota,2N999@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM tRNA synthetase, class II (G, H, P and S)	glyS	-	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
SX3_k127_3983394_5	1220534.B655_1456	7.81e-35	135.0	COG1679@1|root,arCOG04278@2157|Archaea,2XTY6@28890|Euryarchaeota,23NR8@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
SX3_k127_3983394_0	717606.PaecuDRAFT_2033	1.994e-123	445.0	COG1361@1|root,COG3291@1|root,COG1361@2|Bacteria,COG3291@2|Bacteria,1UKER@1239|Firmicutes,4HFP1@91061|Bacilli	91061|Bacilli	M	TIGRFAM conserved repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
SX3_k127_3983394_3	1386089.N865_05350	6.692e-72	278.0	COG4733@1|root,COG4733@2|Bacteria,2I7XV@201174|Actinobacteria,4FK2V@85021|Intrasporangiaceae	201174|Actinobacteria	M	Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	fn3
SX3_k127_3983394_2	1123252.ATZF01000027_gene1612	2.994e-113	413.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
SX3_k127_3983394_4	1246995.AFR_22960	2.722e-70	273.0	COG4733@1|root,COG4733@2|Bacteria,2H7QD@201174|Actinobacteria,4DJZF@85008|Micromonosporales	201174|Actinobacteria	NU	Fibronectin type III domain	-	-	2.7.11.1	ko:K12567	ko05410,ko05414,map05410,map05414	-	-	-	ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812	-	-	-	fn3
SX3_k127_3983394_1	717606.PaecuDRAFT_2033	1.856e-121	439.0	COG1361@1|root,COG3291@1|root,COG1361@2|Bacteria,COG3291@2|Bacteria,1UKER@1239|Firmicutes,4HFP1@91061|Bacilli	91061|Bacilli	M	TIGRFAM conserved repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
SX3_k127_3983394_6	673860.AciM339_0730	6.258e-31	143.0	COG4934@1|root,arCOG05978@1|root,arCOG03669@2157|Archaea,arCOG05978@2157|Archaea,2Y7X2@28890|Euryarchaeota,3F38G@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	Pro-kuma_activ,fn3
SX3_k127_3983394_7	1280390.CBQR020000166_gene4415	7.738e-17	97.0	COG3934@1|root,COG5297@1|root,COG3934@2|Bacteria,COG5297@2|Bacteria,1V19K@1239|Firmicutes,4IQ1F@91061|Bacilli,2765Y@186822|Paenibacillaceae	91061|Bacilli	G	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3983394_8	439496.RBY4I_741	2.814e-06	55.0	2FGPB@1|root,348IX@2|Bacteria,1P3QZ@1224|Proteobacteria,2UUFD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_3983394_9	589924.Ferp_2348	0.0007856	46.0	COG3609@1|root,arCOG01009@2157|Archaea,2Y1Z9@28890|Euryarchaeota,246JG@183980|Archaeoglobi	183980|Archaeoglobi	K	CopG Arc MetJ family	-	-	-	ko:K07746	-	-	-	-	ko00000,ko02048	-	-	-	RHH_1
SX3_k127_4024798_4	1033810.HLPCO_001694	1.794e-32	136.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SX3_k127_4024798_2	1054217.TALC_00289	3.614e-42	164.0	arCOG01449@1|root,arCOG01449@2157|Archaea,2Y2FC@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4024798_15	710686.Mycsm_00677	1.617e-06	57.0	COG2852@1|root,COG2852@2|Bacteria,2GKCY@201174|Actinobacteria,236GB@1762|Mycobacteriaceae	201174|Actinobacteria	S	Protein of unknown function (DUF559)	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_4,DUF559
SX3_k127_4024798_1	1094980.Mpsy_0157	2.709e-145	499.0	COG0210@1|root,arCOG00787@1|root,arCOG00787@2157|Archaea,arCOG00797@2157|Archaea,arCOG00798@2157|Archaea,2Y7VX@28890|Euryarchaeota,2N94N@224756|Methanomicrobia	224756|Methanomicrobia	L	PD-(D/E)XK nuclease superfamily	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
SX3_k127_4024798_8	293227.XP_008714750.1	4.235e-19	104.0	KOG0379@1|root,KOG0379@2759|Eukaryota,38C0C@33154|Opisthokonta,3NXSA@4751|Fungi,3QR0G@4890|Ascomycota,20DTX@147545|Eurotiomycetes,3MPZ6@451870|Chaetothyriomycetidae	4751|Fungi	S	Kelch	KEL2	GO:0000003,GO:0000133,GO:0000278,GO:0000281,GO:0000746,GO:0000747,GO:0000755,GO:0000910,GO:0000935,GO:0001100,GO:0005575,GO:0005622,GO:0005623,GO:0005628,GO:0005737,GO:0005856,GO:0005874,GO:0005875,GO:0005881,GO:0005933,GO:0005934,GO:0005935,GO:0005937,GO:0005938,GO:0007049,GO:0007088,GO:0007096,GO:0007163,GO:0007346,GO:0008104,GO:0008150,GO:0008360,GO:0009987,GO:0010564,GO:0010639,GO:0010948,GO:0015630,GO:0016020,GO:0019953,GO:0022402,GO:0022413,GO:0022414,GO:0022603,GO:0022604,GO:0030427,GO:0030428,GO:0031110,GO:0031111,GO:0031113,GO:0031115,GO:0031333,GO:0031500,GO:0032153,GO:0032155,GO:0032187,GO:0032231,GO:0032271,GO:0032272,GO:0032465,GO:0032505,GO:0032506,GO:0032878,GO:0032879,GO:0032886,GO:0032956,GO:0032970,GO:0032991,GO:0033036,GO:0033043,GO:0034613,GO:0035371,GO:0035838,GO:0035839,GO:0035840,GO:0036214,GO:0042763,GO:0042764,GO:0042995,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043254,GO:0043332,GO:0044087,GO:0044422,GO:0044424,GO:0044430,GO:0044444,GO:0044446,GO:0044448,GO:0044463,GO:0044464,GO:0044703,GO:0044764,GO:0045786,GO:0045839,GO:0045930,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051049,GO:0051128,GO:0051129,GO:0051179,GO:0051285,GO:0051286,GO:0051301,GO:0051302,GO:0051493,GO:0051494,GO:0051641,GO:0051704,GO:0051726,GO:0051783,GO:0051784,GO:0060627,GO:0061160,GO:0061172,GO:0061245,GO:0061246,GO:0061640,GO:0065007,GO:0065008,GO:0070507,GO:0070727,GO:0071944,GO:0071963,GO:0072697,GO:0090337,GO:0097427,GO:0099070,GO:0099080,GO:0099081,GO:0099512,GO:0099513,GO:0099568,GO:0099738,GO:0110053,GO:0120025,GO:0120038,GO:1901987,GO:1901988,GO:1901990,GO:1901991,GO:1902405,GO:1902410,GO:1902486,GO:1902903,GO:1902904,GO:1903047,GO:1904511,GO:1904758,GO:1990151,GO:1990615,GO:1990752,GO:1990778,GO:1990896,GO:2000099,GO:2000100,GO:2000114,GO:2000769,GO:2000771	-	-	-	-	-	-	-	-	-	-	Kelch_1,Kelch_3,Kelch_4,Kelch_5
SX3_k127_4024798_11	28072.Nos7524_4621	1.998e-17	98.0	COG0823@1|root,COG2304@1|root,COG3209@1|root,COG3210@1|root,COG0823@2|Bacteria,COG2304@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,1GQ0G@1117|Cyanobacteria,1HN8U@1161|Nostocales	1117|Cyanobacteria	MU	Dystroglycan-type cadherin-like domains.	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,He_PIG,RHS_repeat
SX3_k127_4024798_12	3067.XP_002958790.1	1.428e-16	94.0	KOG0271@1|root,KOG0272@1|root,KOG0271@2759|Eukaryota,KOG0272@2759|Eukaryota	2759|Eukaryota	S	U4 snRNA binding	-	-	-	ko:K11127	-	-	-	-	ko00000,ko03032	-	-	-	DUF2235,DUF4062,NACHT,Pkinase_Tyr,TROVE,WD40
SX3_k127_4024798_14	1210908.HSB1_05800	1.541e-10	74.0	COG3398@1|root,arCOG02611@2157|Archaea,2XV4M@28890|Euryarchaeota,23V38@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
SX3_k127_4024798_7	330214.NIDE4309	4.196e-19	94.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	23S_rRNA_IVP,DegT_DnrJ_EryC1
SX3_k127_4024798_9	1005999.GLGR_2082	2.173e-18	101.0	COG2373@1|root,COG2373@2|Bacteria,1QV7E@1224|Proteobacteria,1SM3U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	TIGRFAM Outer membrane protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2
SX3_k127_4024798_13	192952.MM_2441	9.117e-12	74.0	COG3398@1|root,arCOG02611@2157|Archaea,2XV4M@28890|Euryarchaeota,2NB4N@224756|Methanomicrobia	224756|Methanomicrobia	K	Winged helix-turn-helix DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
SX3_k127_4024798_5	1123400.KB904758_gene2277	2.673e-28	124.0	COG1100@1|root,COG1100@2|Bacteria,1RIAW@1224|Proteobacteria,1S6H6@1236|Gammaproteobacteria,462KK@72273|Thiotrichales	72273|Thiotrichales	S	Ras of Complex, Roc, domain of DAPkinase	-	-	-	-	-	-	-	-	-	-	-	-	Ras
SX3_k127_4024798_10	3055.EDP05664	1.745e-17	94.0	KOG3599@1|root,KOG3599@2759|Eukaryota,383ZN@33090|Viridiplantae,34KCY@3041|Chlorophyta	3041|Chlorophyta	PT	Lipoxygenase homology 2 (beta barrel) domain	-	-	-	-	-	-	-	-	-	-	-	-	PLAT
SX3_k127_4024798_0	936136.ARRT01000007_gene1059	3.832e-183	595.0	COG1404@1|root,COG1404@2|Bacteria,1PSEZ@1224|Proteobacteria,2V4M5@28211|Alphaproteobacteria,4BFDK@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
SX3_k127_4024798_6	936136.ARRT01000007_gene1060	7.29e-26	115.0	COG2333@1|root,COG2333@2|Bacteria,1RE10@1224|Proteobacteria,2U7SC@28211|Alphaproteobacteria,4BI87@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	competence protein COMEC	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SX3_k127_4024889_9	1144275.COCOR_06089	2.893e-23	116.0	COG2885@1|root,COG4733@1|root,COG2885@2|Bacteria,COG4733@2|Bacteria,1MX1F@1224|Proteobacteria,42UTB@68525|delta/epsilon subdivisions,2WQUW@28221|Deltaproteobacteria,2YUE1@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,DUF11,OmpA,Phenol_MetA_deg,TSP_3
SX3_k127_4024889_1	439481.Aboo_0301	5.136e-113	371.0	COG1013@1|root,arCOG01601@2157|Archaea,2XT3E@28890|Euryarchaeota,3F2JH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	vorB	-	1.2.7.1,1.2.7.7	ko:K00170,ko:K00187	ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R07160,R08034,R08566,R08567	RC00004,RC00250,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
SX3_k127_4024889_0	673860.AciM339_0764	1.345e-136	445.0	COG0674@1|root,arCOG01608@2157|Archaea,2XTB0@28890|Euryarchaeota,3F36A@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Pyruvate:ferredoxin oxidoreductase core domain II	vorA	-	1.2.7.1,1.2.7.7	ko:K00169,ko:K00186	ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R07160,R08034,R08566,R08567	RC00004,RC00250,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
SX3_k127_4024889_8	529709.PYCH_06650	1.133e-26	120.0	COG1144@1|root,arCOG01605@2157|Archaea,2XY2F@28890|Euryarchaeota,245HQ@183968|Thermococci	183968|Thermococci	C	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity	vorD	-	1.2.7.7	ko:K00188	ko00280,ko01100,map00280,map01100	-	R07160,R08566,R08567	RC00004,RC02833,RC02856	br01601,ko00000,ko00001,ko01000	-	-	-	Fer4
SX3_k127_4024889_5	673860.AciM339_0766	1.934e-55	213.0	COG1014@1|root,arCOG01603@2157|Archaea,2XVFR@28890|Euryarchaeota,3F2RB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	porC	-	1.2.7.1,1.2.7.7	ko:K00172,ko:K00189	ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R07160,R08034,R08566,R08567	RC00004,RC00250,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
SX3_k127_4024889_7	673860.AciM339_1575	1.257e-50	190.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y4JI@28890|Euryarchaeota,3F328@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	DnaB-like helicase C terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
SX3_k127_4024889_2	439481.Aboo_0417	1.912e-107	369.0	COG0020@1|root,arCOG01532@2157|Archaea,2XSW1@28890|Euryarchaeota,3F2F2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.89	ko:K15888	ko00900,map00900	-	R09730	RC00279,RC02839	ko00000,ko00001,ko01000	-	-	-	Prenyltransf
SX3_k127_4024889_6	673860.AciM339_0285	8.969e-54	199.0	COG1938@1|root,arCOG00347@2157|Archaea,2XT93@28890|Euryarchaeota,3F2T7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
SX3_k127_4024889_3	485913.Krac_3329	1.965e-81	286.0	COG1222@1|root,COG1222@2|Bacteria	2|Bacteria	O	protein catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	AAA,TPR_19,TPR_8
SX3_k127_4024889_4	304371.MCP_2659	4.63e-64	239.0	COG2262@1|root,arCOG00353@2157|Archaea,2XT2W@28890|Euryarchaeota,2N99S@224756|Methanomicrobia	224756|Methanomicrobia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
SX3_k127_4044427_15	575540.Isop_0876	1.216e-09	70.0	COG2931@1|root,COG2931@2|Bacteria,2J1K0@203682|Planctomycetes	203682|Planctomycetes	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4044427_13	715226.ABI_39890	5.618e-20	105.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HCBP_related,HemolysinCabind,Peptidase_M10_C
SX3_k127_4044427_11	1121373.KB903621_gene1961	4.039e-28	132.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	3.2.1.4,3.4.24.40	ko:K01179,ko:K01406,ko:K07004	ko00500,ko01100,ko01503,map00500,map01100,map01503	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000,ko01002	-	GH5,GH9	-	Calx-beta,Exo_endo_phos,HemolysinCabind,LTD,Laminin_G_3
SX3_k127_4044427_12	6669.EFX88967	8.037e-26	123.0	COG1100@1|root,KOG0098@2759|Eukaryota,38D6D@33154|Opisthokonta,3BB4T@33208|Metazoa,3CV5J@33213|Bilateria,41VTH@6656|Arthropoda	33208|Metazoa	U	GTP binding. It is involved in the biological process described with protein transport	RAB2A	GO:0000139,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0006464,GO:0006807,GO:0006810,GO:0006886,GO:0006888,GO:0006996,GO:0007030,GO:0007154,GO:0007165,GO:0007264,GO:0007265,GO:0008104,GO:0008150,GO:0008152,GO:0009987,GO:0010256,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016192,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019538,GO:0023052,GO:0030424,GO:0031090,GO:0031594,GO:0031982,GO:0031984,GO:0032482,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033036,GO:0033267,GO:0034613,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0036477,GO:0042175,GO:0042886,GO:0042995,GO:0043005,GO:0043025,GO:0043167,GO:0043168,GO:0043170,GO:0043195,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043679,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044297,GO:0044306,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044432,GO:0044444,GO:0044446,GO:0044456,GO:0044463,GO:0044464,GO:0045184,GO:0045202,GO:0046907,GO:0048193,GO:0048471,GO:0050789,GO:0050794,GO:0050803,GO:0050807,GO:0050896,GO:0051128,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0051716,GO:0061175,GO:0065007,GO:0065008,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0097159,GO:0097367,GO:0097458,GO:0098588,GO:0098791,GO:0098793,GO:0098794,GO:0098827,GO:0098975,GO:0099175,GO:0120025,GO:0120038,GO:0150034,GO:1901265,GO:1901363,GO:1901564	-	ko:K07877	ko04152,map04152	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
SX3_k127_4044427_8	673860.AciM339_0678	3.095e-59	216.0	COG0177@1|root,arCOG00459@2157|Archaea,2XTY1@28890|Euryarchaeota,3F2MB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	GO:0000702,GO:0000703,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006289,GO:0006296,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033683,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF123,EndIII_4Fe-2S,HhH-GPD
SX3_k127_4044427_1	1120973.AQXL01000135_gene1468	1.095e-135	449.0	COG1228@1|root,COG1228@2|Bacteria,1TP2J@1239|Firmicutes,4HAVY@91061|Bacilli,27837@186823|Alicyclobacillaceae	91061|Bacilli	Q	Amidohydrolase family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU39370	Amidohydro_1,Amidohydro_3
SX3_k127_4044427_3	697303.Thewi_0616	8.503e-109	364.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,42FF9@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Acyl-CoA dehydrogenase	bcd	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016627,GO:0016628,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363	1.3.1.108,1.3.8.1	ko:K00248,ko:K22430	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SX3_k127_4044427_9	1249627.D779_3143	3.612e-31	144.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,1RZ6G@1236|Gammaproteobacteria,1X1H2@135613|Chromatiales	135613|Chromatiales	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
SX3_k127_4044427_0	1459636.NTE_00936	7e-181	575.0	COG0151@1|root,arCOG04415@2157|Archaea	2157|Archaea	F	Belongs to the GARS family	purD1	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C
SX3_k127_4044427_14	192952.MM_1274	2.475e-16	93.0	COG0169@1|root,arCOG01033@2157|Archaea,2XV7K@28890|Euryarchaeota,2N9IF@224756|Methanomicrobia	224756|Methanomicrobia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25,2.7.1.71,4.2.1.10	ko:K00014,ko:K00891,ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R02413,R03084	RC00002,RC00078,RC00206,RC00848	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0923	SKI,Shikimate_DH,Shikimate_dh_N
SX3_k127_4044427_7	1121289.JHVL01000063_gene282	2.658e-70	253.0	COG4948@1|root,COG4948@2|Bacteria,1TQMS@1239|Firmicutes,25DGF@186801|Clostridia,36FGS@31979|Clostridiaceae	186801|Clostridia	M	mandelate racemase muconate lactonizing	-	-	5.1.1.20	ko:K19802	-	-	R10938	RC03309	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
SX3_k127_4044427_6	272569.rrnAC0232	8.169e-73	259.0	COG3367@1|root,arCOG02828@2157|Archaea,2XTPS@28890|Euryarchaeota,23UDG@183963|Halobacteria	183963|Halobacteria	S	Domain of unknown function (DUF1611_N) Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1611,DUF1611_N
SX3_k127_4044427_4	1236689.MMALV_03080	2.37e-107	365.0	COG0063@1|root,arCOG00018@2157|Archaea,2XU4W@28890|Euryarchaeota,3F2MH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
SX3_k127_4044427_16	469378.Ccur_11940	2.986e-09	70.0	COG5652@1|root,COG5652@2|Bacteria,2HV8T@201174|Actinobacteria,4CWHF@84998|Coriobacteriia	84998|Coriobacteriia	S	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
SX3_k127_4044427_10	304371.MCP_0299	6.37e-29	129.0	COG0517@1|root,arCOG00606@2157|Archaea,2XX11@28890|Euryarchaeota,2N9VZ@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SX3_k127_4044427_2	1236689.MMALV_13780	7.662e-131	434.0	COG0277@1|root,arCOG00337@2157|Archaea,2XT5C@28890|Euryarchaeota	28890|Euryarchaeota	C	COG0277 FAD FMN-containing dehydrogenases	glcD2	-	1.1.2.4,1.1.3.15	ko:K00102,ko:K00104,ko:K06911	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_8
SX3_k127_4044427_5	1054217.TALC_01391	1.704e-79	280.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota,242ID@183967|Thermoplasmata	2157|Archaea	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
SX3_k127_4073627_1	529709.PYCH_05560	3.286e-05	57.0	COG1572@1|root,arCOG07086@2157|Archaea,2Y2HS@28890|Euryarchaeota,2436N@183968|Thermococci	183968|Thermococci	G	CARDB	-	-	-	-	-	-	-	-	-	-	-	-	CARDB
SX3_k127_4073627_2	1365176.N186_03800	0.0007565	51.0	COG1873@1|root,arCOG02155@2157|Archaea	2157|Archaea	S	PRC-barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PRC
SX3_k127_4073627_0	1297742.A176_00747	6.597e-31	143.0	COG1372@1|root,COG2911@1|root,COG3209@1|root,COG1372@2|Bacteria,COG2911@2|Bacteria,COG3209@2|Bacteria,1PEID@1224|Proteobacteria,438II@68525|delta/epsilon subdivisions,2X3TD@28221|Deltaproteobacteria,2YX2B@29|Myxococcales	28221|Deltaproteobacteria	LM	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4080959_0	414684.RC1_3822	4.322e-47	194.0	COG3898@1|root,COG3898@2|Bacteria,1R052@1224|Proteobacteria	1224|Proteobacteria	S	HemY domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4080959_1	572546.Arcpr_1327	1.137e-39	165.0	COG5256@1|root,arCOG01561@2157|Archaea,2XTNM@28890|Euryarchaeota,246VQ@183980|Archaeoglobi	183980|Archaeoglobi	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
SX3_k127_4081971_1	368407.Memar_1583	2.09e-62	221.0	COG1691@1|root,arCOG02465@2157|Archaea,2XTIH@28890|Euryarchaeota,2N9MD@224756|Methanomicrobia	224756|Methanomicrobia	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
SX3_k127_4081971_6	439481.Aboo_0588	9.758e-21	105.0	COG1340@1|root,arCOG01159@2157|Archaea,2Y70M@28890|Euryarchaeota,3F338@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	archaeal coiled-coil protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4081971_10	1265756.AWZW01000001_gene112	3.728e-06	54.0	COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2U99J@28211|Alphaproteobacteria,4BQV7@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	GO:0003674,GO:0003824,GO:0008150,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
SX3_k127_4081971_3	1304888.ATWF01000002_gene504	5.019e-46	174.0	COG0755@1|root,COG0755@2|Bacteria,2GF7F@200930|Deferribacteres	200930|Deferribacteres	O	Cytochrome C assembly protein	-	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
SX3_k127_4081971_4	192952.MM_2397	1.609e-41	161.0	COG2386@1|root,arCOG01328@2157|Archaea,2XTAS@28890|Euryarchaeota,2NAJD@224756|Methanomicrobia	224756|Methanomicrobia	O	CcmB protein	-	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
SX3_k127_4081971_2	192952.MM_2398	4.817e-57	208.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUWP@28890|Euryarchaeota,2NAQN@224756|Methanomicrobia	224756|Methanomicrobia	E	ATPases associated with a variety of cellular activities	-	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
SX3_k127_4081971_0	1094980.Mpsy_1084	4.227e-69	260.0	COG1138@1|root,arCOG00270@2157|Archaea,2XUDS@28890|Euryarchaeota,2NADH@224756|Methanomicrobia	224756|Methanomicrobia	O	Cytochrome C assembly protein	-	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	Cytochrom_C_asm
SX3_k127_4081971_7	263820.PTO0428	1.68e-19	100.0	COG1522@1|root,arCOG01581@2157|Archaea,2Y7QI@28890|Euryarchaeota,24262@183967|Thermoplasmata	183967|Thermoplasmata	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
SX3_k127_4081971_8	458817.Shal_2928	1.456e-10	75.0	COG3005@1|root,COG3005@2|Bacteria,1R4UP@1224|Proteobacteria,1RYPM@1236|Gammaproteobacteria,2Q8MP@267890|Shewanellaceae	1236|Gammaproteobacteria	C	TIGRFAM cytochrome C family protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Paired_CXXCH_1
SX3_k127_4081971_5	485914.Hmuk_0622	1.019e-30	141.0	COG3291@1|root,COG3979@1|root,arCOG02546@2157|Archaea,arCOG07581@2157|Archaea,2Y7P8@28890|Euryarchaeota,23S91@183963|Halobacteria	183963|Halobacteria	G	protein contain chitin-binding domain type 3	-	-	-	-	-	-	-	-	-	-	-	-	CBM_5_12,PKD
SX3_k127_4081971_9	1535422.ND16A_0735	3.988e-09	68.0	COG3005@1|root,COG3005@2|Bacteria,1R4UP@1224|Proteobacteria,1RZUI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	cytochrome C family protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Paired_CXXCH_1
SX3_k127_4100195_2	1192034.CAP_1107	1.28e-08	65.0	2CBKC@1|root,32RTJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4100195_0	1054217.TALC_00518	1.981e-106	355.0	COG0258@1|root,arCOG04050@2157|Archaea,2XTJD@28890|Euryarchaeota,241MU@183967|Thermoplasmata	183967|Thermoplasmata	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
SX3_k127_4100195_3	1192034.CAP_0930	3.5e-08	68.0	COG1572@1|root,COG1572@2|Bacteria,1QX45@1224|Proteobacteria,42YA1@68525|delta/epsilon subdivisions,2WTP9@28221|Deltaproteobacteria,2YWVC@29|Myxococcales	28221|Deltaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	HYR,VCBS
SX3_k127_4100195_1	383372.Rcas_3601	2.93e-15	89.0	COG2885@1|root,COG3266@1|root,COG2885@2|Bacteria,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	-	GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704	-	-	-	-	-	-	-	-	-	-	Collagen,DUF389,PG_binding_1
SX3_k127_4100195_4	362976.HQ_3090A	3.484e-06	53.0	arCOG01312@1|root,arCOG01312@2157|Archaea,2XVGY@28890|Euryarchaeota,23VD8@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
SX3_k127_4116379_14	1173028.ANKO01000159_gene5233	9.141e-07	62.0	COG0689@1|root,COG2931@1|root,COG0689@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Cadherin_3,DUF4082,DUF4347,He_PIG,HemolysinCabind
SX3_k127_4116379_13	870187.Thini_1774	6.652e-10	72.0	COG2885@1|root,COG2885@2|Bacteria,1R508@1224|Proteobacteria,1RS7G@1236|Gammaproteobacteria,46256@72273|Thiotrichales	72273|Thiotrichales	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
SX3_k127_4116379_6	693661.Arcve_1931	8.907e-71	247.0	COG1136@1|root,arCOG00922@2157|Archaea,2XUH3@28890|Euryarchaeota,2460M@183980|Archaeoglobi	183980|Archaeoglobi	E	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_4116379_15	1246484.D479_12218	3.601e-06	61.0	COG3127@1|root,COG3127@2|Bacteria	2|Bacteria	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX3_k127_4116379_1	387631.Asulf_02087	2.786e-170	545.0	COG1257@1|root,arCOG04260@2157|Archaea,2XTV9@28890|Euryarchaeota,245ZK@183980|Archaeoglobi	183980|Archaeoglobi	I	Hydroxymethylglutaryl-CoA reductase, degradative	-	-	1.1.1.88	ko:K00054	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R02081	RC00004,RC00644	ko00000,ko00001,ko01000	-	-	-	HMG-CoA_red
SX3_k127_4116379_7	673860.AciM339_0592	4.305e-59	218.0	COG0350@1|root,COG1515@1|root,arCOG00929@2157|Archaea,arCOG02724@2157|Archaea,2XURE@28890|Euryarchaeota,3F2XY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	nfi	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Endonuclease_5
SX3_k127_4116379_9	645512.GCWU000246_01008	3.125e-55	205.0	COG1893@1|root,COG1893@2|Bacteria,3TAIK@508458|Synergistetes	508458|Synergistetes	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
SX3_k127_4116379_12	192952.MM_1754	1.788e-12	74.0	COG3612@1|root,arCOG04418@2157|Archaea	2157|Archaea	L	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	DUF2240
SX3_k127_4116379_17	397948.Cmaq_1401	0.0001389	55.0	COG0106@1|root,arCOG00618@2157|Archaea,2XQSB@28889|Crenarchaeota	28889|Crenarchaeota	E	Belongs to the HisA HisF family	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
SX3_k127_4116379_8	1121472.AQWN01000005_gene2505	8.406e-56	198.0	COG0822@1|root,COG0822@2|Bacteria,1V3H9@1239|Firmicutes,24HDD@186801|Clostridia,261QI@186807|Peptococcaceae	186801|Clostridia	C	FeS cluster assembly scaffold protein NifU	nifU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
SX3_k127_4116379_10	1121861.KB899926_gene2592	1.758e-35	154.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,2TRS3@28211|Alphaproteobacteria,2JREK@204441|Rhodospirillales	204441|Rhodospirillales	G	Maltogenic Amylase, C-terminal domain	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
SX3_k127_4116379_4	2325.TKV_c02260	4.293e-104	360.0	COG0297@1|root,COG0297@2|Bacteria,1UHYC@1239|Firmicutes,24ANR@186801|Clostridia,42FD7@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SX3_k127_4116379_0	247490.KSU1_C1305	3.591e-305	977.0	COG0296@1|root,COG0296@2|Bacteria,2IXS1@203682|Planctomycetes	203682|Planctomycetes	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
SX3_k127_4116379_2	1303518.CCALI_02107	5.034e-145	478.0	COG1543@1|root,COG1543@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 57 family	-	GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576	2.4.1.18	ko:K03406,ko:K16149	ko00500,ko01100,ko01110,ko02020,ko02030,map00500,map01100,map01110,map02020,map02030	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko02035	-	GH57	-	DUF1957,Glyco_hydro_57,Glyco_transf_4,Glycos_transf_1
SX3_k127_4116379_11	1343739.PAP_02570	4.277e-31	134.0	COG1109@1|root,arCOG00768@2157|Archaea,2XWDJ@28890|Euryarchaeota,243AV@183968|Thermococci	183968|Thermococci	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I	-	-	-	-	-	-	-	-	-	-	-	-	PGM_PMM_I
SX3_k127_4116379_3	195522.BD01_0025	3.487e-112	377.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,243QQ@183968|Thermococci	183968|Thermococci	M	Nucleotidyl transferase	-	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
SX3_k127_4116379_16	326427.Cagg_3152	3.645e-06	59.0	COG1361@1|root,COG1470@1|root,COG1361@2|Bacteria,COG1470@2|Bacteria,2GA7Y@200795|Chloroflexi,376PQ@32061|Chloroflexia	32061|Chloroflexia	M	SMART Parallel beta-helix repeat	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NPCBM_assoc
SX3_k127_4116379_5	263820.PTO0417	1.402e-84	284.0	COG0480@1|root,arCOG01559@2157|Archaea,2XUMQ@28890|Euryarchaeota,241J6@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
SX3_k127_412210_4	1121441.AUCX01000025_gene1682	7.631e-06	54.0	COG1404@1|root,COG1404@2|Bacteria,1REF1@1224|Proteobacteria,42RS0@68525|delta/epsilon subdivisions,2WNDK@28221|Deltaproteobacteria,2MAVV@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,Peptidase_S8
SX3_k127_412210_0	1158292.JPOE01000002_gene2954	2.067e-153	506.0	COG1032@1|root,COG1032@2|Bacteria,1NP6A@1224|Proteobacteria	1224|Proteobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding
SX3_k127_412210_3	1054217.TALC_00209	1.511e-19	97.0	COG0838@1|root,arCOG01557@2157|Archaea,2XX2K@28890|Euryarchaeota	28890|Euryarchaeota	C	NADH ubiquinone oxidoreductase subunit 3 (Chain a)	nuoA	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016695,GO:0046995,GO:0051911,GO:0055114	1.5.98.3,1.6.5.3	ko:K00330,ko:K22158	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.9.1	-	iAF692.Mbar_A3412	Oxidored_q4
SX3_k127_412210_1	1054217.TALC_00210	2.425e-54	198.0	COG0377@1|root,arCOG01554@2157|Archaea,2XTP1@28890|Euryarchaeota,241SV@183967|Thermoplasmata	183967|Thermoplasmata	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	1.5.98.3,1.6.5.3	ko:K00331,ko:K22159	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.9.1	-	-	Oxidored_q6
SX3_k127_412210_2	387631.Asulf_01801	7.617e-29	123.0	COG0852@1|root,arCOG01551@2157|Archaea,2XZK1@28890|Euryarchaeota	28890|Euryarchaeota	C	NADH ubiquinone oxidoreductase 27 kD subunit	-	-	1.5.98.3,1.6.5.3	ko:K00332,ko:K22160	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.9.1	-	-	Complex1_30kDa
SX3_k127_4138179_2	867845.KI911784_gene1447	4.992e-28	128.0	COG1100@1|root,COG1100@2|Bacteria,2G9IC@200795|Chloroflexi,3777W@32061|Chloroflexia	32061|Chloroflexia	S	SMART Ras small GTPase, Ras type	-	-	-	-	-	-	-	-	-	-	-	-	Ras
SX3_k127_4138179_0	1054217.TALC_01532	5.786e-54	199.0	COG4860@1|root,arCOG04366@2157|Archaea,2XYAX@28890|Euryarchaeota,241R5@183967|Thermoplasmata	183967|Thermoplasmata	K	ArsR transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	ArsR
SX3_k127_4138179_3	439481.Aboo_0153	4.685e-08	67.0	COG1572@1|root,arCOG03999@1|root,arCOG05978@1|root,arCOG02532@2157|Archaea,arCOG03999@2157|Archaea,arCOG05978@2157|Archaea,2Y4KU@28890|Euryarchaeota	28890|Euryarchaeota	E	Clostripain family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C11
SX3_k127_4138179_1	765912.Thimo_1752	1.012e-31	145.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,1RZ6G@1236|Gammaproteobacteria,1X1H2@135613|Chromatiales	135613|Chromatiales	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
SX3_k127_4157545_2	679926.Mpet_0327	7.451e-33	146.0	COG0457@1|root,arCOG03032@2157|Archaea,arCOG03038@2157|Archaea,2XUNW@28890|Euryarchaeota,2NAF9@224756|Methanomicrobia	224756|Methanomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_6,TPR_8
SX3_k127_4157545_0	439481.Aboo_0187	2.96e-79	299.0	COG1109@1|root,arCOG00767@2157|Archaea,2Y66D@28890|Euryarchaeota,3F34Q@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
SX3_k127_4157545_3	215803.DB30_0610	1.171e-13	85.0	COG2854@1|root,COG2854@2|Bacteria	2|Bacteria	Q	intermembrane phospholipid transfer	ttg2D	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
SX3_k127_4157545_1	326427.Cagg_2459	3.486e-52	210.0	COG1716@1|root,COG1716@2|Bacteria,2G9KV@200795|Chloroflexi,376M0@32061|Chloroflexia	32061|Chloroflexia	T	PFAM Forkhead-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Peptidase_C11
SX3_k127_4158297_2	485914.Hmuk_0096	1.353e-06	61.0	arCOG01314@1|root,arCOG01314@2157|Archaea,2XVNC@28890|Euryarchaeota,23TF3@183963|Halobacteria	183963|Halobacteria	L	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF4350
SX3_k127_4158297_0	246969.TAM4_1127	2.599e-119	394.0	COG0714@1|root,arCOG00434@2157|Archaea,2XSZU@28890|Euryarchaeota,24353@183968|Thermococci	183968|Thermococci	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
SX3_k127_4158297_1	926569.ANT_09540	2.076e-47	186.0	COG1361@1|root,COG1721@1|root,COG1361@2|Bacteria,COG1721@2|Bacteria,2G7JJ@200795|Chloroflexi	200795|Chloroflexi	M	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
SX3_k127_4174654_13	1249627.D779_3142	3.929e-18	97.0	COG4254@1|root,COG4254@2|Bacteria	2|Bacteria	UW	PFAM FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,FecR,LysM,fn3
SX3_k127_4174654_2	1041930.Mtc_1964	7.116e-62	225.0	COG2309@1|root,arCOG01890@2157|Archaea,2XU28@28890|Euryarchaeota	28890|Euryarchaeota	E	Leucyl aminopeptidase (Aminopeptidase t)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M29
SX3_k127_4174654_9	1341151.ASZU01000015_gene2122	1.832e-39	154.0	COG1670@1|root,COG1670@2|Bacteria,1UWKW@1239|Firmicutes,4IE06@91061|Bacilli,27C06@186824|Thermoactinomycetaceae	91061|Bacilli	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
SX3_k127_4174654_5	864702.OsccyDRAFT_4470	1.24e-56	215.0	COG1451@1|root,COG1451@2|Bacteria,1G6GG@1117|Cyanobacteria,1HB3P@1150|Oscillatoriales	1117|Cyanobacteria	S	WLM domain	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
SX3_k127_4174654_7	485915.Dret_0263	2.691e-46	175.0	COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,42RKH@68525|delta/epsilon subdivisions,2WPJZ@28221|Deltaproteobacteria,2MGMQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
SX3_k127_4174654_16	439481.Aboo_1188	4.772e-09	64.0	arCOG13555@1|root,arCOG13555@2157|Archaea,2Y72W@28890|Euryarchaeota,3F3AQ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4174654_1	1041930.Mtc_1149	1.227e-97	331.0	COG0530@1|root,arCOG02881@2157|Archaea,2Y2BH@28890|Euryarchaeota,2NAGG@224756|Methanomicrobia	224756|Methanomicrobia	P	Sodium/calcium exchanger protein	-	-	-	ko:K07300	-	-	-	-	ko00000,ko02000	2.A.19	-	-	Na_Ca_ex
SX3_k127_4174654_3	273116.14325248	3.339e-58	207.0	COG0663@1|root,arCOG01849@2157|Archaea,2XWNM@28890|Euryarchaeota	28890|Euryarchaeota	S	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
SX3_k127_4174654_0	545695.TREAZ_2782	1.706e-104	351.0	COG2309@1|root,COG2309@2|Bacteria,2J605@203691|Spirochaetes	203691|Spirochaetes	E	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M29
SX3_k127_4174654_15	1236689.MMALV_00420	4.256e-14	73.0	arCOG05368@1|root,arCOG05368@2157|Archaea,2Y1EG@28890|Euryarchaeota,3F2W6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4174654_14	1480694.DC28_04080	1.257e-17	98.0	COG0841@1|root,COG3420@1|root,COG0841@2|Bacteria,COG3420@2|Bacteria,2J58E@203691|Spirochaetes	203691|Spirochaetes	P	this gene contains a nucleotide ambiguity which may be the result of a sequencing error	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,Big_3_3
SX3_k127_4174654_10	368407.Memar_1957	3.97e-35	146.0	COG2890@1|root,arCOG00109@2157|Archaea,2XWJZ@28890|Euryarchaeota,2N9RR@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM methyltransferase small	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
SX3_k127_4174654_6	456442.Mboo_1590	8.062e-47	184.0	COG1926@1|root,arCOG00041@2157|Archaea,2XWHP@28890|Euryarchaeota	28890|Euryarchaeota	F	phosphoribosyltransferases	prt	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
SX3_k127_4174654_8	246969.TAM4_1096	1.691e-44	181.0	COG1404@1|root,arCOG00702@2157|Archaea,2XTGN@28890|Euryarchaeota,24359@183968|Thermococci	183968|Thermococci	O	Serine protease with a broad substrate specificity	-	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005509,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0070011,GO:0071704,GO:0140096,GO:1901564	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PPC,Peptidase_S8
SX3_k127_4174654_11	1089551.KE386572_gene1743	2.276e-26	128.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,2U12Y@28211|Alphaproteobacteria,4BRG6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
SX3_k127_4174654_17	1089548.KI783301_gene205	7.601e-08	67.0	COG1404@1|root,COG3291@1|root,COG4412@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,COG4412@2|Bacteria,1TPUY@1239|Firmicutes,4HBDE@91061|Bacilli	91061|Bacilli	O	COG1404 Subtilisin-like serine proteases	bprF	-	-	ko:K13276	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Inhibitor_I9,PKD,Peptidase_M6,Peptidase_S8
SX3_k127_4174654_12	273116.14324228	2.689e-21	99.0	COG0456@1|root,arCOG00833@2157|Archaea,2Y0G0@28890|Euryarchaeota,241VK@183967|Thermoplasmata	183967|Thermoplasmata	K	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
SX3_k127_4174654_4	1457250.BBMO01000001_gene123	5.378e-58	210.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT95@28890|Euryarchaeota,23TFM@183963|Halobacteria	183963|Halobacteria	M	Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
SX3_k127_4183659_6	1449355.JQNR01000003_gene646	1.885e-07	63.0	COG3055@1|root,COG4934@1|root,COG3055@2|Bacteria,COG4934@2|Bacteria	2|Bacteria	O	collagen metabolic process	nanM	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0016853,GO:0016854,GO:0016857,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	5.1.3.24	ko:K17948	-	-	-	-	ko00000,ko01000	-	-	-	CarboxypepD_reg,Kelch_1,Kelch_2,Kelch_4,Kelch_6
SX3_k127_4183659_9	192952.MM_2114	1.064e-05	57.0	arCOG06532@1|root,arCOG06532@2157|Archaea,2Y12Z@28890|Euryarchaeota,2NA6P@224756|Methanomicrobia	224756|Methanomicrobia	S	Transmembrane exosortase (Exosortase_EpsH)	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
SX3_k127_4183659_4	1112216.JH594425_gene1244	4.015e-20	106.0	COG2911@1|root,COG2931@1|root,COG2982@1|root,COG3637@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG2982@2|Bacteria,COG3637@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,2K0IP@204457|Sphingomonadales	204457|Sphingomonadales	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HCBP_related,He_PIG,HemolysinCabind
SX3_k127_4183659_8	1169154.KB897782_gene4969	8.567e-06	58.0	COG2133@1|root,COG3291@1|root,COG3828@1|root,COG2133@2|Bacteria,COG3291@2|Bacteria,COG3828@2|Bacteria,2GJFY@201174|Actinobacteria	201174|Actinobacteria	G	Glucose sorbosone	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,DUF1080,GSDH,PKD,ThuA
SX3_k127_4183659_7	751944.HALDL1_05775	1.168e-06	60.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWHT@28890|Euryarchaeota,23V64@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	gntR	-	-	-	-	-	-	-	-	-	-	-	HTH_24,HTH_5,MarR_2
SX3_k127_4183659_5	1170562.Cal6303_1326	1.19e-08	68.0	COG2885@1|root,COG2885@2|Bacteria,1G2YF@1117|Cyanobacteria,1HMYH@1161|Nostocales	1117|Cyanobacteria	M	COGs COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)protein	-	-	-	ko:K02557,ko:K03286	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1,1.B.6	-	-	OmpA
SX3_k127_4183659_2	387631.Asulf_00521	1.819e-27	131.0	COG3979@1|root,COG5306@1|root,arCOG02420@1|root,arCOG03511@1|root,arCOG03553@1|root,arCOG09173@1|root,arCOG02420@2157|Archaea,arCOG03508@2157|Archaea,arCOG03511@2157|Archaea,arCOG03553@2157|Archaea,arCOG07581@2157|Archaea,arCOG09173@2157|Archaea	2157|Archaea	C	PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,DUF2341,PKD,Pilin_N,S_layer_C
SX3_k127_4183659_3	1178540.BA70_04980	3.061e-26	117.0	COG1309@1|root,COG1309@2|Bacteria,1TPXF@1239|Firmicutes,4HCMD@91061|Bacilli,1ZDYI@1386|Bacillus	91061|Bacilli	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
SX3_k127_4183659_0	714943.Mucpa_6319	1.462e-57	210.0	COG1136@1|root,COG1136@2|Bacteria,4NE5N@976|Bacteroidetes,1IPVI@117747|Sphingobacteriia	976|Bacteroidetes	P	Part of the ABC transporter complex LolCDE involved in the translocation of	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_4183659_1	645991.Sgly_2938	2.747e-28	133.0	COG0577@1|root,COG0577@2|Bacteria,1TPHU@1239|Firmicutes,248RV@186801|Clostridia,260CG@186807|Peptococcaceae	186801|Clostridia	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX3_k127_4201485_3	945713.IALB_0021	2.838e-06	60.0	COG1404@1|root,COG3303@1|root,COG1404@2|Bacteria,COG3303@2|Bacteria	2|Bacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	1.7.2.2	ko:K03385	ko00910,ko01120,ko05132,map00910,map01120,map05132	M00530	R05712	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Calx-beta,Cytochrom_C552,Cytochrome_C554,FlgD_ig,Paired_CXXCH_1,VCBS
SX3_k127_4201485_0	1120954.ATXE01000003_gene303	4.987e-34	150.0	COG1409@1|root,COG3291@1|root,COG1409@2|Bacteria,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4DP00@85009|Propionibacteriales	201174|Actinobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PKD
SX3_k127_4201485_2	926566.Terro_3653	1.542e-09	72.0	COG2010@1|root,COG2010@2|Bacteria,3Y650@57723|Acidobacteria,2JKDC@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Cytochrome_CBB3,Paired_CXXCH_1
SX3_k127_4201485_1	1150399.AQYK01000002_gene3209	5.542e-34	152.0	COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4FKX3@85023|Microbacteriaceae	201174|Actinobacteria	G	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	wcoG	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PKD
SX3_k127_4219691_4	1236689.MMALV_00680	6.439e-15	76.0	COG2888@1|root,arCOG01989@2157|Archaea,2Y6XW@28890|Euryarchaeota,3F2UA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Domain of unknown function (DUF1610)	-	-	-	ko:K07580	-	-	-	-	ko00000	-	-	-	DUF1610
SX3_k127_4219691_5	224325.AF_0574	1.147e-10	67.0	COG2092@1|root,arCOG01988@2157|Archaea	2157|Archaea	J	Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA	ef1b	-	-	ko:K03232	-	-	-	-	ko00000,ko03012	-	-	-	EF1_GNE
SX3_k127_4219691_0	1094980.Mpsy_2342	2.734e-46	186.0	COG0467@1|root,arCOG01178@2157|Archaea,2Y0GM@28890|Euryarchaeota	28890|Euryarchaeota	T	PFAM GvpD gas vesicle	gvpD	-	-	-	-	-	-	-	-	-	-	-	GvpD
SX3_k127_4219691_2	439481.Aboo_0295	3.039e-29	121.0	COG2098@1|root,arCOG04705@2157|Archaea,2XY43@28890|Euryarchaeota,3F2SX@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD)	mptD	-	4.1.2.25	ko:K09739	ko00790,map00790	-	R03504	RC00721,RC00943	ko00000,ko00001,ko01000	-	-	-	DHNA
SX3_k127_4219691_3	644968.DFW101_3599	6.451e-18	93.0	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,42QV4@68525|delta/epsilon subdivisions,2WMR6@28221|Deltaproteobacteria,2M8CV@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
SX3_k127_4219691_1	42256.RradSPS_0152	3.982e-37	149.0	COG0688@1|root,COG0688@2|Bacteria,2GMMF@201174|Actinobacteria	201174|Actinobacteria	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
SX3_k127_4251490_17	673860.AciM339_0591	5.166e-33	135.0	COG0125@1|root,arCOG01891@2157|Archaea,2XTAM@28890|Euryarchaeota,3F2RW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Thymidylate kinase	tmk	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
SX3_k127_4251490_16	5888.CAK87026	1.226e-37	151.0	COG3914@1|root,KOG4626@2759|Eukaryota,3ZDCY@5878|Ciliophora	5878|Ciliophora	GOT	TPR Domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
SX3_k127_4251490_2	1054217.TALC_01540	3.311e-114	378.0	COG0150@1|root,arCOG00639@2157|Archaea,2XTBA@28890|Euryarchaeota,241K3@183967|Thermoplasmata	183967|Thermoplasmata	F	phosphoribosylformylglycinamidine cyclo-ligase activity	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
SX3_k127_4251490_3	404589.Anae109_1276	3.827e-104	353.0	COG1899@1|root,COG1899@2|Bacteria,1MVC6@1224|Proteobacteria,42QED@68525|delta/epsilon subdivisions,2WJWR@28221|Deltaproteobacteria,2Z18F@29|Myxococcales	28221|Deltaproteobacteria	O	Deoxyhypusine synthase	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
SX3_k127_4251490_19	673860.AciM339_0014	1.608e-23	116.0	COG1305@1|root,arCOG02165@2157|Archaea,2Y71W@28890|Euryarchaeota,3F376@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
SX3_k127_4251490_6	529709.PYCH_10130	1.158e-88	309.0	COG0446@1|root,arCOG01069@2157|Archaea,2Y7FC@28890|Euryarchaeota,245K3@183968|Thermococci	183968|Thermococci	P	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.6.3.3	ko:K17870	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
SX3_k127_4251490_0	521011.Mpal_1668	1.426e-167	559.0	COG0370@1|root,arCOG00359@2157|Archaea,2XU46@28890|Euryarchaeota,2N913@224756|Methanomicrobia	224756|Methanomicrobia	P	Ferrous iron transport B domain protein	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
SX3_k127_4251490_11	1220534.B655_2250	3.892e-55	201.0	COG1321@1|root,arCOG02099@2157|Archaea,2XSWC@28890|Euryarchaeota,23P0S@183925|Methanobacteria	183925|Methanobacteria	K	Iron dependent	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
SX3_k127_4251490_5	1487921.DP68_09850	7.935e-91	309.0	COG1032@1|root,COG1032@2|Bacteria,1TQF0@1239|Firmicutes,24A0T@186801|Clostridia,36DKI@31979|Clostridiaceae	186801|Clostridia	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SX3_k127_4251490_13	529709.PYCH_05100	5.592e-47	177.0	COG1634@1|root,arCOG04303@2157|Archaea,2XT8R@28890|Euryarchaeota,24344@183968|Thermococci	183968|Thermococci	H	Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP)	mptE	-	2.7.6.3	ko:K07142	ko00790,map00790	-	R03503	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	MAF_flag10
SX3_k127_4251490_9	1236689.MMALV_16870	1.576e-71	251.0	COG1831@1|root,arCOG00893@2157|Archaea,2XTX7@28890|Euryarchaeota,3F2KE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	TatD related DNase	tatD	-	-	ko:K07049	-	-	-	-	ko00000	-	-	-	TatD_DNase
SX3_k127_4251490_22	1120954.ATXE01000003_gene303	0.0001177	54.0	COG1409@1|root,COG3291@1|root,COG1409@2|Bacteria,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4DP00@85009|Propionibacteriales	201174|Actinobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PKD
SX3_k127_4251490_20	644281.MFS40622_1163	5.034e-08	65.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota	28890|Euryarchaeota	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24,HTH_5
SX3_k127_4251490_15	1094980.Mpsy_2607	4.795e-46	181.0	COG1305@1|root,arCOG03600@2157|Archaea,2Y7F7@28890|Euryarchaeota,2NA6Q@224756|Methanomicrobia	224756|Methanomicrobia	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
SX3_k127_4251490_12	933801.Ahos_1388	4.135e-52	191.0	COG0513@1|root,arCOG00078@2157|Archaea,2XPRR@28889|Crenarchaeota	28889|Crenarchaeota	J	Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	flpA	GO:0000154,GO:0000494,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006325,GO:0006364,GO:0006396,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008213,GO:0008276,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016074,GO:0016569,GO:0016570,GO:0016571,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0022613,GO:0031123,GO:0031126,GO:0031167,GO:0032259,GO:0033967,GO:0034470,GO:0034641,GO:0034660,GO:0034963,GO:0036009,GO:0036211,GO:0042054,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043414,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051276,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140096,GO:0140098,GO:0140102,GO:1901360,GO:1901363,GO:1901564,GO:1990258,GO:1990259	-	ko:K04795	-	-	-	-	ko00000,ko03009	-	-	-	Fibrillarin
SX3_k127_4251490_18	1041930.Mtc_1116	6.734e-33	146.0	COG2319@1|root,arCOG07544@1|root,arCOG02491@2157|Archaea,arCOG07544@2157|Archaea,2Y226@28890|Euryarchaeota,2NB3Y@224756|Methanomicrobia	224756|Methanomicrobia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
SX3_k127_4251490_10	1054217.TALC_00245	5.604e-67	242.0	COG1498@1|root,arCOG01923@2157|Archaea,2XUEA@28890|Euryarchaeota,241U5@183967|Thermoplasmata	183967|Thermoplasmata	J	snoRNA binding domain, fibrillarin	-	-	-	ko:K14564	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	Nop
SX3_k127_4251490_8	706587.Desti_0172	6.512e-73	257.0	COG2048@1|root,COG2048@2|Bacteria,1RC7G@1224|Proteobacteria,43B85@68525|delta/epsilon subdivisions,2WMVG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Heterodisulfide reductase subunit B	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
SX3_k127_4251490_14	706587.Desti_0171	8.253e-47	175.0	COG1150@1|root,COG1150@2|Bacteria,1R44N@1224|Proteobacteria,42NTE@68525|delta/epsilon subdivisions,2WJN8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Nitrate reductase gamma subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	-
SX3_k127_4251490_21	311424.DhcVS_1498	5.069e-06	52.0	COG2002@1|root,COG2002@2|Bacteria,2GAUX@200795|Chloroflexi,34DEE@301297|Dehalococcoidia	301297|Dehalococcoidia	K	toxin-antitoxin pair type II binding	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4251490_4	1220534.B655_1308	5.334e-103	346.0	COG1131@1|root,arCOG00194@2157|Archaea,2XTJV@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SX3_k127_4251490_1	1041930.Mtc_2048	2.401e-117	392.0	COG0842@1|root,arCOG01463@2157|Archaea,2XVQJ@28890|Euryarchaeota,2NB7X@224756|Methanomicrobia	224756|Methanomicrobia	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
SX3_k127_4251490_7	1089553.Tph_c19520	2.415e-80	274.0	COG1856@1|root,COG1856@2|Bacteria,1V23U@1239|Firmicutes,24E3M@186801|Clostridia,42GSP@68295|Thermoanaerobacterales	186801|Clostridia	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K09711	-	-	-	-	ko00000	-	-	-	Radical_SAM
SX3_k127_4257005_0	387631.Asulf_01816	4.581e-253	803.0	COG1148@1|root,arCOG02234@2157|Archaea,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,245U1@183980|Archaeoglobi	183980|Archaeoglobi	C	Heterodisulfide reductase subunit A and related polyferredoxins	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,FlpD,Pyr_redox_2
SX3_k127_4257005_4	880072.Desac_0835	1.358e-56	212.0	COG1908@1|root,COG2512@1|root,COG1908@2|Bacteria,COG2512@2|Bacteria,1RCZY@1224|Proteobacteria,42TFE@68525|delta/epsilon subdivisions,2WPDR@28221|Deltaproteobacteria,2MRBM@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	FlpD
SX3_k127_4257005_1	644281.MFS40622_0209	4.909e-221	704.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23QA9@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
SX3_k127_4257005_3	760568.Desku_1475	3.832e-113	372.0	COG0685@1|root,COG0685@2|Bacteria,1UHX4@1239|Firmicutes,25E62@186801|Clostridia,25ZZU@186807|Peptococcaceae	186801|Clostridia	C	PFAM Methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
SX3_k127_4257005_2	335543.Sfum_0797	4.177e-147	485.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,42MF5@68525|delta/epsilon subdivisions,2WKC6@28221|Deltaproteobacteria,2MQU1@213462|Syntrophobacterales	68525|delta/epsilon subdivisions	C	PFAM 2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
SX3_k127_4263041_0	672.VV93_v1c14520	5.127e-14	88.0	COG2304@1|root,COG2911@1|root,COG4932@1|root,COG2304@2|Bacteria,COG2911@2|Bacteria,COG4932@2|Bacteria,1P8N9@1224|Proteobacteria,1SCTK@1236|Gammaproteobacteria,1Y32F@135623|Vibrionales	135623|Vibrionales	M	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4263041_1	880073.Calab_2183	1.324e-13	86.0	COG3210@1|root,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Cadherin,Calx-beta,DUF5122,Haemagg_act,HemolysinCabind,PPC,VCBS
SX3_k127_4300698_0	589924.Ferp_2334	7.074e-271	849.0	COG2414@1|root,arCOG00706@2157|Archaea,2XTUP@28890|Euryarchaeota,245XW@183980|Archaeoglobi	28890|Euryarchaeota	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
SX3_k127_432265_0	273068.TTE1217	1.175e-216	682.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,42FIA@68295|Thermoanaerobacterales	186801|Clostridia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01847,ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
SX3_k127_432265_2	224325.AF_2218	5.923e-37	144.0	COG0346@1|root,arCOG02706@2157|Archaea,2XY0R@28890|Euryarchaeota,2469B@183980|Archaeoglobi	183980|Archaeoglobi	E	Glyoxalase-like domain	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
SX3_k127_432265_1	102129.Lepto7375DRAFT_0842	2.487e-38	165.0	COG1572@1|root,COG3209@1|root,COG1572@2|Bacteria,COG3209@2|Bacteria,1G4UG@1117|Cyanobacteria,1HH6U@1150|Oscillatoriales	1117|Cyanobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,RHS_repeat
SX3_k127_432265_3	1283299.AUKG01000001_gene3451	7.449e-11	76.0	COG1361@1|root,COG2931@1|root,COG1361@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,FG-GAP,HemolysinCabind
SX3_k127_4357735_1	331113.SNE_A18580	1.481e-16	90.0	COG3070@1|root,COG3070@2|Bacteria	2|Bacteria	K	positive regulation of type IV pilus biogenesis	-	-	-	ko:K07343	-	-	-	-	ko00000	-	-	-	TfoX_N
SX3_k127_4357735_0	1408433.JHXV01000002_gene371	3.784e-36	156.0	COG4409@1|root,COG4409@2|Bacteria,4NJCZ@976|Bacteroidetes,1I0GI@117743|Flavobacteriia,2PBJF@246874|Cryomorphaceae	976|Bacteroidetes	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
SX3_k127_4357735_3	1380393.JHVP01000019_gene37	2.75e-05	57.0	COG4409@1|root,COG4409@2|Bacteria,2ICIA@201174|Actinobacteria	201174|Actinobacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
SX3_k127_4357735_2	1238186.AOCN01000012_gene1301	2.992e-06	60.0	COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4FKX3@85023|Microbacteriaceae	201174|Actinobacteria	G	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	wcoG	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PKD
SX3_k127_437135_1	1041930.Mtc_1396	2.22e-162	516.0	COG1155@1|root,arCOG00868@2157|Archaea,2XT8I@28890|Euryarchaeota,2N93M@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
SX3_k127_437135_7	204669.Acid345_2536	7.601e-25	123.0	COG0308@1|root,COG0457@1|root,COG0308@2|Bacteria,COG0457@2|Bacteria,3Y3C5@57723|Acidobacteria,2JI5M@204432|Acidobacteriia	204432|Acidobacteriia	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1,TPR_11,TPR_16
SX3_k127_437135_6	1333523.L593_10660	3.037e-27	130.0	COG3291@1|root,COG3325@1|root,arCOG02546@2157|Archaea,arCOG07840@2157|Archaea,2Y7YU@28890|Euryarchaeota,241E0@183963|Halobacteria	183963|Halobacteria	G	chitinase	-	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	Glyco_hydro_18,PKD
SX3_k127_437135_0	1094980.Mpsy_2507	5.454e-247	771.0	COG1156@1|root,arCOG00865@2157|Archaea,2XSYQ@28890|Euryarchaeota,2N97D@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
SX3_k127_437135_3	351160.RCIX2034	1.468e-77	264.0	COG1394@1|root,arCOG04101@2157|Archaea,2XTQ5@28890|Euryarchaeota,2N9IG@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	iAF692.Mbar_A0384	ATP-synt_D
SX3_k127_437135_5	351160.RCIX2338	4.501e-44	171.0	COG1901@1|root,arCOG01239@2157|Archaea,2XTSB@28890|Euryarchaeota,2N9P7@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs	trmY	-	2.1.1.257	ko:K16317	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltrn_RNA_2
SX3_k127_437135_4	338969.Rfer_2227	2.726e-48	198.0	COG0457@1|root,COG1396@1|root,COG3899@1|root,COG0457@2|Bacteria,COG1396@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2VPH8@28216|Betaproteobacteria,4AF3Y@80864|Comamonadaceae	28216|Betaproteobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD
SX3_k127_437135_2	1054217.TALC_00918	1.225e-146	477.0	COG0541@1|root,arCOG01228@2157|Archaea,2XTWX@28890|Euryarchaeota,241J3@183967|Thermoplasmata	183967|Thermoplasmata	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	srp54	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
SX3_k127_4377669_1	561175.KB894093_gene2988	6.541e-09	62.0	COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4ER4V@85012|Streptosporangiales	201174|Actinobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122,Malectin,PKD
SX3_k127_4377669_0	1120985.AUMI01000004_gene1325	4.843e-73	256.0	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,4H387@909932|Negativicutes	909932|Negativicutes	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_4377669_2	1120746.CCNL01000011_gene1741	4.975e-05	54.0	COG0577@1|root,COG0577@2|Bacteria,2NP20@2323|unclassified Bacteria	2|Bacteria	V	MacB-like periplasmic core domain	macB2	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX3_k127_4384003_1	1382359.JIAL01000001_gene923	3.536e-20	107.0	COG3170@1|root,COG4409@1|root,COG5306@1|root,COG3170@2|Bacteria,COG4409@2|Bacteria,COG5306@2|Bacteria,3Y2GG@57723|Acidobacteria,2JI5J@204432|Acidobacteriia	2|Bacteria	G	Belongs to the peptidase S8 family	exbB2	-	-	ko:K03561,ko:K12287,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000,ko02044	1.A.30.2.1	-	-	Big_3_2,DUF2341,Laminin_G_3,MotA_ExbB
SX3_k127_4384003_3	935948.KE386495_gene1383	2.151e-16	82.0	COG0298@1|root,COG0298@2|Bacteria,1VFE0@1239|Firmicutes,24UXU@186801|Clostridia,42HA3@68295|Thermoanaerobacterales	186801|Clostridia	O	PFAM hydrogenase expression formation protein (HUPF HYPC)	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
SX3_k127_4384003_2	1054217.TALC_01114	2.326e-19	95.0	COG0375@1|root,arCOG04426@2157|Archaea,2XZI2@28890|Euryarchaeota	28890|Euryarchaeota	S	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
SX3_k127_4384003_0	1236689.MMALV_11490	4.669e-127	423.0	COG0409@1|root,arCOG04428@2157|Archaea,2XTJA@28890|Euryarchaeota,3F2F1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	TIGRFAM hydrogenase expression formation protein HypD	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
SX3_k127_4384003_4	83219.PM02_00150	0.0004183	54.0	COG2911@1|root,COG2931@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,3ZUZ8@60136|Sulfitobacter	28211|Alphaproteobacteria	Q	Hint domain	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin_3,DUF4214,GDPD,He_PIG,HemolysinCabind,PPC,Peptidase_M10_C
SX3_k127_4389256_0	1459636.NTE_01726	1.362e-152	494.0	COG0192@1|root,arCOG07444@2157|Archaea,41S5P@651137|Thaumarchaeota	651137|Thaumarchaeota	H	S-adenosylmethionine synthetase	-	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
SX3_k127_4389256_3	452637.Oter_2657	4.129e-31	128.0	COG0295@1|root,COG0295@2|Bacteria,46YPU@74201|Verrucomicrobia,3K9YT@414999|Opitutae	414999|Opitutae	F	cytidine and deoxycytidylate deaminase	-	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
SX3_k127_4389256_1	529709.PYCH_09500	2.362e-71	253.0	COG0281@1|root,arCOG01331@2157|Archaea,2XTRZ@28890|Euryarchaeota,242SQ@183968|Thermococci	183968|Thermococci	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
SX3_k127_4389256_5	264732.Moth_0241	8.802e-20	106.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	ASH,Calx-beta,DUF11,DUF1573,F5_F8_type_C,FG-GAP,Glyco_hyd_101C,Glyco_hydro_101,NPCBM_assoc,SASA
SX3_k127_4389256_7	1324957.K933_16512	1.966e-08	69.0	COG3291@1|root,arCOG07560@1|root,arCOG07781@1|root,arCOG10187@1|root,arCOG02546@2157|Archaea,arCOG07560@2157|Archaea,arCOG07781@2157|Archaea,arCOG10187@2157|Archaea,2XYYY@28890|Euryarchaeota,23X3J@183963|Halobacteria	183963|Halobacteria	S	PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,PKD
SX3_k127_4389256_8	436308.Nmar_1073	4.807e-06	61.0	COG3794@1|root,arCOG05978@1|root,arCOG07813@1|root,arCOG02926@2157|Archaea,arCOG05978@2157|Archaea,arCOG07813@2157|Archaea	2157|Archaea	C	LamG domain protein jellyroll fold domain protein	-	-	2.7.11.1	ko:K12567	ko05410,ko05414,map05410,map05414	-	-	-	ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812	-	-	-	Copper-bind,GSDH,Laminin_G_3,ThuA,fn3
SX3_k127_4389256_2	1132509.C447_14541	1.718e-58	215.0	COG0697@1|root,arCOG00271@2157|Archaea,2XT64@28890|Euryarchaeota,23TZT@183963|Halobacteria	183963|Halobacteria	G	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SX3_k127_4389256_4	186497.PF1588	2.001e-27	122.0	COG2428@1|root,arCOG00968@2157|Archaea,2XVH8@28890|Euryarchaeota,242IZ@183968|Thermococci	183968|Thermococci	S	Predicted SAM-dependent RNA methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	RNA_Me_trans
SX3_k127_4389256_6	395493.BegalDRAFT_0040	1.168e-11	77.0	COG2885@1|root,COG2885@2|Bacteria,1R508@1224|Proteobacteria,1RS7G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	OmpA MotB	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
SX3_k127_439270_8	192952.MM_0690	7.279e-18	90.0	COG1499@1|root,arCOG04149@2157|Archaea,2XUAI@28890|Euryarchaeota,2N9GP@224756|Methanomicrobia	224756|Methanomicrobia	J	pfam nmd3	-	-	-	ko:K07562	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko03009	-	-	-	NMD3
SX3_k127_439270_5	515635.Dtur_0743	2.351e-35	141.0	COG1853@1|root,COG1853@2|Bacteria	2|Bacteria	S	FMN binding	flr	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
SX3_k127_439270_9	439481.Aboo_1309	5.2e-12	77.0	COG1989@1|root,arCOG02298@2157|Archaea,2Y6ZX@28890|Euryarchaeota,3F315@33867|unclassified Euryarchaeota	28890|Euryarchaeota	N	Archaeal Peptidase A24 C-terminus Type II	-	-	3.4.23.52	ko:K07991	-	-	-	-	ko00000,ko01000,ko01002,ko02035,ko02044	-	-	-	Arc_PepC_II
SX3_k127_439270_1	439481.Aboo_0716	3.152e-84	287.0	COG0467@1|root,arCOG01171@2157|Archaea,2XTU3@28890|Euryarchaeota,3F31P@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	Rad51	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
SX3_k127_439270_3	340099.Teth39_2103	1.582e-40	166.0	COG2131@1|root,COG2131@2|Bacteria,1V3PU@1239|Firmicutes,24HF0@186801|Clostridia,42GBV@68295|Thermoanaerobacterales	186801|Clostridia	F	PFAM CMP dCMP deaminase zinc-binding	comEB	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
SX3_k127_439270_6	439481.Aboo_1545	2.233e-33	138.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y4JI@28890|Euryarchaeota,3F328@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	DnaB-like helicase C terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
SX3_k127_439270_10	1114856.C496_12217	8.136e-12	77.0	arCOG02435@1|root,arCOG02435@2157|Archaea,2XX22@28890|Euryarchaeota,23VIS@183963|Halobacteria	183963|Halobacteria	F	Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base	-	-	-	-	-	-	-	-	-	-	-	-	Nuc_deoxyrib_tr
SX3_k127_439270_4	1236689.MMALV_03850	5.504e-40	160.0	COG2016@1|root,arCOG00985@2157|Archaea,2XX1R@28890|Euryarchaeota,3F2SI@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase	-	GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K07575	-	-	-	-	ko00000	-	-	-	DUF1947,PUA
SX3_k127_439270_0	1236689.MMALV_10390	2.808e-85	302.0	COG0037@1|root,arCOG00042@2157|Archaea,2XTEZ@28890|Euryarchaeota,3F2HB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	D	PP-loop family	tuc1	-	2.8.1.15	ko:K21947	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3
SX3_k127_439270_11	587753.EY04_11115	3.594e-06	61.0	COG2304@1|root,COG2931@1|root,COG3170@1|root,COG4932@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,COG3170@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,1RMZW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	von willebrand factor, type A	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,VCBS
SX3_k127_439270_2	1382359.JIAL01000001_gene3036	4.786e-69	256.0	COG0308@1|root,COG0308@2|Bacteria,3Y3ZS@57723|Acidobacteria,2JK79@204432|Acidobacteriia	204432|Acidobacteriia	E	Phospholipase B	-	-	-	-	-	-	-	-	-	-	-	-	Phospholip_B
SX3_k127_439270_7	673860.AciM339_1006	9.566e-30	121.0	COG1594@1|root,arCOG00579@2157|Archaea,2XXU7@28890|Euryarchaeota,3F2T6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	RNA polymerase subunit 9	tfs2	-	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	RNA_POL_M_15KD,TFIIS_C
SX3_k127_4395755_4	1203605.HMPREF1531_01237	5.195e-07	59.0	COG3637@1|root,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	ko:K12980	-	-	-	-	ko00000,ko01005	-	-	-	OMP_b-brl,Surface_Ag_2
SX3_k127_4395755_5	268739.Nmlp_2650	5.843e-05	58.0	COG1361@1|root,COG1470@1|root,COG3291@1|root,arCOG03612@1|root,arCOG04500@1|root,arCOG07554@1|root,arCOG02081@2157|Archaea,arCOG02089@2157|Archaea,arCOG02510@2157|Archaea,arCOG03612@2157|Archaea,arCOG04500@2157|Archaea,arCOG07554@2157|Archaea,2XWGB@28890|Euryarchaeota,23UX2@183963|Halobacteria	183963|Halobacteria	M	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4395755_0	1094980.Mpsy_3151	6.621e-257	872.0	COG5520@1|root,arCOG03769@1|root,arCOG07561@1|root,arCOG03769@2157|Archaea,arCOG07561@2157|Archaea,arCOG09138@2157|Archaea,2XV3J@28890|Euryarchaeota,2NBAU@224756|Methanomicrobia	224756|Methanomicrobia	K	glycoside hydrolase, family	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4395755_1	760568.Desku_0544	8.558e-158	509.0	COG0422@1|root,COG0422@2|Bacteria,1TNZ3@1239|Firmicutes,247JE@186801|Clostridia,260F0@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17,4.1.99.23	ko:K03147,ko:K22465	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
SX3_k127_4395755_3	195250.CM001776_gene1220	1.483e-43	184.0	COG2304@1|root,COG3209@1|root,COG2304@2|Bacteria,COG3209@2|Bacteria,1GJ0D@1117|Cyanobacteria,1H29D@1129|Synechococcus	1117|Cyanobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,RHS_repeat,SdrD_B
SX3_k127_4395755_2	471854.Dfer_2050	6.989e-65	254.0	COG2831@1|root,COG2931@1|root,COG2831@2|Bacteria,COG2931@2|Bacteria,4NKIR@976|Bacteroidetes,47S7V@768503|Cytophagia	976|Bacteroidetes	Q	SMART Integrin alpha beta-propellor repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,FG-GAP,HYR,VCBS
SX3_k127_443284_0	868131.MSWAN_2165	7.445e-118	394.0	COG2327@1|root,arCOG04826@2157|Archaea	2157|Archaea	S	PFAM Polysaccharide pyruvyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	PS_pyruv_trans
SX3_k127_443284_1	235985.BBPN01000035_gene807	1.716e-07	61.0	COG1522@1|root,COG1522@2|Bacteria,2GKP4@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_AsnC-type
SX3_k127_4461851_7	373903.Hore_04230	1.157e-06	61.0	COG1470@1|root,COG1470@2|Bacteria,1TVG5@1239|Firmicutes,25PWD@186801|Clostridia,3WBRE@53433|Halanaerobiales	186801|Clostridia	G	CarboxypepD_reg-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
SX3_k127_4461851_2	673860.AciM339_0274	9.053e-41	155.0	COG2125@1|root,arCOG01946@2157|Archaea,2XXZJ@28890|Euryarchaeota,3F2RJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eS6 family	rps6e	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904	-	ko:K02991	ko01521,ko03010,ko04066,ko04150,ko04151,ko04371,ko04714,ko04910,ko05205,map01521,map03010,map04066,map04150,map04151,map04371,map04714,map04910,map05205	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S6e
SX3_k127_4461851_1	647113.Metok_0259	3.004e-174	554.0	COG3276@1|root,arCOG01563@2157|Archaea,2XUKU@28890|Euryarchaeota,23QPD@183939|Methanococci	183939|Methanococci	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2g	-	-	ko:K03242	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,eIF2_C
SX3_k127_4461851_4	673860.AciM339_1445	2.48e-13	75.0	COG1412@1|root,arCOG04312@2157|Archaea,2Y0D4@28890|Euryarchaeota,3F2SM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	V	Fcf1	-	-	-	ko:K07158	-	-	-	-	ko00000	-	-	-	PIN
SX3_k127_4461851_0	880072.Desac_1143	0.0	1126.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,2MQB6@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
SX3_k127_4461851_8	304371.MCP_1921	5.65e-06	54.0	arCOG03097@1|root,arCOG03097@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4461851_6	1497679.EP56_15045	5.129e-08	64.0	COG1695@1|root,COG1695@2|Bacteria,1VAKA@1239|Firmicutes,4IR4U@91061|Bacilli,26N79@186820|Listeriaceae	91061|Bacilli	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
SX3_k127_4461851_3	673860.AciM339_0553	2.793e-29	119.0	COG1522@1|root,arCOG01117@2157|Archaea,2XZY2@28890|Euryarchaeota,3F3G3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
SX3_k127_4461851_5	304371.MCP_2576	2.149e-08	66.0	arCOG07655@1|root,arCOG07655@2157|Archaea,2XU2P@28890|Euryarchaeota,2NB24@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4468568_0	42256.RradSPS_0059	7.077e-07	60.0	COG2885@1|root,COG2931@1|root,COG4254@1|root,COG2885@2|Bacteria,COG2931@2|Bacteria,COG4254@2|Bacteria,2HENQ@201174|Actinobacteria,4CQR9@84995|Rubrobacteria	84995|Rubrobacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2
SX3_k127_4468568_1	243231.GSU1945	2.114e-06	61.0	COG3209@1|root,COG3291@1|root,COG3209@2|Bacteria,COG3291@2|Bacteria,1Q4PP@1224|Proteobacteria,42YRG@68525|delta/epsilon subdivisions,2WUJR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Bacterial Ig-like domain (group 3)	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3
SX3_k127_4471282_4	4897.EQC53016	2.553e-06	59.0	COG0382@1|root,KOG1381@2759|Eukaryota,38EGV@33154|Opisthokonta,3NXJY@4751|Fungi,3QNF6@4890|Ascomycota,3MCM7@451866|Taphrinomycotina	4751|Fungi	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate	COQ2	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008412,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016765,GO:0019866,GO:0031090,GO:0031224,GO:0031300,GO:0031301,GO:0031304,GO:0031305,GO:0031966,GO:0031967,GO:0031975,GO:0032592,GO:0042180,GO:0042181,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0098573,GO:1901576,GO:1901661,GO:1901663	2.5.1.39	ko:K06125	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00128	R05000,R05616,R07273	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	iMM904.YNR041C,iND750.YNR041C	UbiA
SX3_k127_4471282_3	1132509.C447_13784	2.449e-06	57.0	COG3413@1|root,arCOG02276@2157|Archaea,2XVCM@28890|Euryarchaeota,23V0F@183963|Halobacteria	183963|Halobacteria	K	DNA binding protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_10
SX3_k127_4471282_1	945713.IALB_2866	1.175e-34	137.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	yiiD	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006473,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0071704,GO:1901564	-	ko:K06323	-	-	-	-	ko00000	-	-	-	Acetyltransf_1,Acetyltransf_10,YiiD_C
SX3_k127_4471282_2	1054217.TALC_01307	3.278e-07	62.0	arCOG14714@1|root,arCOG14714@2157|Archaea,2Y2VC@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4471282_0	331678.Cphamn1_2184	8.257e-51	192.0	COG0042@1|root,COG0042@2|Bacteria,1FDAN@1090|Chlorobi	1090|Chlorobi	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	-	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
SX3_k127_4483687_0	1379698.RBG1_1C00001G0071	4.318e-89	309.0	COG0475@1|root,COG0475@2|Bacteria	2|Bacteria	P	glutathione-regulated potassium exporter activity	kefB	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,PTS_EIIA_2
SX3_k127_4483687_3	314265.R2601_17127	2.859e-27	130.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2TTJZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX3_k127_4483687_1	1121013.P873_08200	3.324e-59	214.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RSA2@1236|Gammaproteobacteria,1X3CK@135614|Xanthomonadales	135614|Xanthomonadales	V	ABC transporter	tptC	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_4483687_4	469382.Hbor_10000	1.396e-08	65.0	arCOG02274@1|root,arCOG02274@2157|Archaea,2XWZ3@28890|Euryarchaeota,23VCI@183963|Halobacteria	183963|Halobacteria	K	Bacterio-opsin activator HTH	-	-	-	-	-	-	-	-	-	-	-	-	HTH_10
SX3_k127_4483687_2	292459.STH2499	4.94e-39	151.0	COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia	186801|Clostridia	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
SX3_k127_4494506_0	521011.Mpal_1394	0.0	1214.0	COG2132@1|root,arCOG05978@1|root,arCOG03914@2157|Archaea,arCOG05978@2157|Archaea,2XUY3@28890|Euryarchaeota	28890|Euryarchaeota	Q	Multicopper	-	-	1.16.3.3	ko:K06324	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_2,Cu-oxidase_3
SX3_k127_4494506_8	673860.AciM339_0292	2.204e-21	112.0	COG4870@1|root,arCOG02501@1|root,arCOG03439@1|root,arCOG02501@2157|Archaea,arCOG03439@2157|Archaea,arCOG03614@2157|Archaea,2XZI4@28890|Euryarchaeota	28890|Euryarchaeota	O	Papain family cysteine protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C1
SX3_k127_4494506_14	497964.CfE428DRAFT_3274	5.522e-06	61.0	COG0737@1|root,COG2374@1|root,COG4733@1|root,COG0737@2|Bacteria,COG2374@2|Bacteria,COG4733@2|Bacteria,46VVX@74201|Verrucomicrobia	74201|Verrucomicrobia	F	5'-nucleotidase, C-terminal domain	-	-	3.1.3.6,3.1.4.16	ko:K01119	ko00230,ko00240,map00230,map00240	-	R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135	RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
SX3_k127_4494506_3	28072.Nos7524_4621	1.149e-41	177.0	COG0823@1|root,COG2304@1|root,COG3209@1|root,COG3210@1|root,COG0823@2|Bacteria,COG2304@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,1GQ0G@1117|Cyanobacteria,1HN8U@1161|Nostocales	1117|Cyanobacteria	MU	Dystroglycan-type cadherin-like domains.	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,He_PIG,RHS_repeat
SX3_k127_4494506_11	351160.RCIX1329	6.079e-12	70.0	arCOG11679@1|root,arCOG11679@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4494506_2	410358.Mlab_1687	8.324e-49	184.0	arCOG04820@1|root,arCOG04820@2157|Archaea,2XX4W@28890|Euryarchaeota	28890|Euryarchaeota	T	PFAM SOUL heme-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SOUL
SX3_k127_4494506_9	877455.Metbo_0027	1.628e-14	87.0	COG0640@1|root,arCOG00731@2157|Archaea,2XYSK@28890|Euryarchaeota	28890|Euryarchaeota	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
SX3_k127_4494506_1	1121405.dsmv_1981	2.682e-57	223.0	COG0784@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42N46@68525|delta/epsilon subdivisions,2WJT4@28221|Deltaproteobacteria,2MPMZ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
SX3_k127_4494506_7	1120966.AUBU01000012_gene21	4.67e-25	122.0	COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG5002@2|Bacteria,4PKV1@976|Bacteroidetes,47Y3E@768503|Cytophagia	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
SX3_k127_4494506_13	386456.JQKN01000001_gene2354	1.756e-06	53.0	arCOG03714@1|root,arCOG03714@2157|Archaea	2157|Archaea	F	ATP cone domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-cone,Mrr_cat
SX3_k127_4494506_10	1227739.Hsw_1986	6.875e-14	84.0	COG2234@1|root,COG2234@2|Bacteria,4NE66@976|Bacteroidetes,47MBT@768503|Cytophagia	976|Bacteroidetes	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
SX3_k127_4494506_5	521011.Mpal_1231	2.581e-39	151.0	COG4978@1|root,arCOG03200@2157|Archaea,2XYDM@28890|Euryarchaeota,2NBJ9@224756|Methanomicrobia	224756|Methanomicrobia	K	transcription activator, effector binding	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
SX3_k127_4494506_6	1380354.JIAN01000008_gene3362	3.649e-34	153.0	COG3291@1|root,COG3420@1|root,COG3291@2|Bacteria,COG3420@2|Bacteria,2GN7G@201174|Actinobacteria	201174|Actinobacteria	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122,Laminin_G_3,Malectin,PKD
SX3_k127_4494506_12	706587.Desti_3313	2.783e-10	74.0	COG3055@1|root,COG3055@2|Bacteria,1MYQG@1224|Proteobacteria,42P3T@68525|delta/epsilon subdivisions,2WKUC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Galactose oxidase, central domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1566,Kelch_1,Kelch_3,Kelch_4,Kelch_6,REJ
SX3_k127_4494506_4	331678.Cphamn1_0515	3.417e-41	166.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
SX3_k127_4499639_2	673860.AciM339_0018	3.073e-22	106.0	COG1326@1|root,arCOG02680@2157|Archaea,2XUFW@28890|Euryarchaeota,3F2TD@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	archaeal Zn-finger protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4499639_1	1142394.PSMK_00960	1.513e-25	117.0	COG0467@1|root,COG0467@2|Bacteria,2IZBF@203682|Planctomycetes	203682|Planctomycetes	T	KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
SX3_k127_4499639_0	351160.RCIX2113	4.037e-26	127.0	COG0784@1|root,arCOG03799@1|root,arCOG06712@1|root,arCOG02393@2157|Archaea,arCOG03799@2157|Archaea,arCOG06712@2157|Archaea	2157|Archaea	T	PAS domain	-	-	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	Anticodon_1,DUF835,GAF_2,GAF_3,HAMP,HATPase_c,HisKA,PAS,PAS_9,Response_reg,zinc_ribbon_2
SX3_k127_4499639_3	673860.AciM339_0019	6.296e-06	61.0	COG0457@1|root,arCOG02493@1|root,arCOG02493@2157|Archaea,arCOG03038@2157|Archaea	2157|Archaea	KLT	Tetratricopeptide TPR_2 repeat protein	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	HTH_24,PQQ_2,PQQ_3,TPR_12,TPR_16,TPR_2,TPR_8
SX3_k127_4511371_3	1089547.KB913013_gene3820	7.792e-05	58.0	COG2373@1|root,COG3291@1|root,COG4932@1|root,COG2373@2|Bacteria,COG3291@2|Bacteria,COG4932@2|Bacteria,4NM7C@976|Bacteroidetes,47RKX@768503|Cytophagia	976|Bacteroidetes	N	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,CHU_C
SX3_k127_4511371_0	673860.AciM339_0753	5.534e-206	715.0	COG1287@1|root,arCOG02044@2157|Archaea,arCOG05365@2157|Archaea,2Y7QJ@28890|Euryarchaeota,3F2NE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	Carboxypeptidase regulatory-like domain	-	-	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	CarboxypepD_reg,PMT_2,STT3
SX3_k127_4511371_1	1236689.MMALV_13650	1.857e-51	192.0	COG1890@1|root,arCOG04186@2157|Archaea,2XSX9@28890|Euryarchaeota,3F2MY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eS1 family	rps3ae	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576	-	ko:K02984	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S3Ae
SX3_k127_4511371_2	673860.AciM339_0306	2.79e-22	102.0	COG2450@1|root,arCOG02263@2157|Archaea,2XXYF@28890|Euryarchaeota,3F3BW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	D	Pfam:DUF552	sepF	-	-	ko:K09152	-	-	-	-	ko00000	-	-	-	SepF
SX3_k127_4526041_0	1236689.MMALV_01850	6.979e-50	197.0	arCOG05338@1|root,arCOG05338@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4526041_1	304371.MCP_0143	1.471e-41	170.0	COG0438@1|root,arCOG01403@2157|Archaea,2XTRH@28890|Euryarchaeota,2N9R4@224756|Methanomicrobia	224756|Methanomicrobia	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SX3_k127_4526041_2	1128421.JAGA01000001_gene2118	7.048e-17	91.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PPC,Peptidase_S8
SX3_k127_4556888_4	909663.KI867150_gene468	4.932e-27	119.0	2C5Z2@1|root,32A20@2|Bacteria,1R1X8@1224|Proteobacteria,43DCC@68525|delta/epsilon subdivisions,2X8IC@28221|Deltaproteobacteria,2MQKW@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF3786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3786
SX3_k127_4556888_2	1121405.dsmv_2843	3.011e-71	267.0	COG1924@1|root,COG1924@2|Bacteria,1RDZA@1224|Proteobacteria,42RYS@68525|delta/epsilon subdivisions,2WNJX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	TIGRFAM CoA-substrate-specific enzyme activase	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
SX3_k127_4556888_1	443144.GM21_2867	2.266e-157	511.0	COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,42NFZ@68525|delta/epsilon subdivisions,2WMBX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
SX3_k127_4556888_0	195522.BD01_0537	1.267e-178	574.0	COG0008@1|root,arCOG00402@2157|Archaea,2XSUM@28890|Euryarchaeota,242RZ@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
SX3_k127_4556888_3	1191523.MROS_2191	4.808e-27	126.0	COG2202@1|root,COG3829@1|root,COG4251@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria	2|Bacteria	T	photoreceptor activity	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	CHASE,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SpoIIE
SX3_k127_4556888_6	1173024.KI912148_gene4184	4.37e-21	102.0	COG2202@1|root,COG2203@1|root,COG4251@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4251@2|Bacteria,1G1Z5@1117|Cyanobacteria,1JHIX@1189|Stigonemataceae	1117|Cyanobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4
SX3_k127_4556888_5	373994.Riv7116_0975	6.898e-22	106.0	COG1100@1|root,COG1100@2|Bacteria,1G5QQ@1117|Cyanobacteria,1HNIS@1161|Nostocales	1117|Cyanobacteria	S	ADP-ribosylation factor family	-	-	-	-	-	-	-	-	-	-	-	-	Ras,Roc
SX3_k127_4556888_7	641526.ADIWIN_3798	3.138e-11	72.0	COG0457@1|root,COG0642@1|root,COG0457@2|Bacteria,COG2205@2|Bacteria,4NI29@976|Bacteroidetes,1HX1A@117743|Flavobacteriia	976|Bacteroidetes	T	Pfam Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,TPR_12,TPR_7,TPR_8
SX3_k127_4557545_24	1242864.D187_008583	1.625e-12	80.0	COG3507@1|root,COG3507@2|Bacteria,1R3V6@1224|Proteobacteria	1224|Proteobacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
SX3_k127_4557545_18	933801.Ahos_1461	1.029e-26	129.0	COG0441@1|root,arCOG00401@2157|Archaea,2XQ02@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr)	thrS	GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-Thr_ED,tRNA-synt_2b
SX3_k127_4557545_0	1041930.Mtc_0248	3.923e-147	508.0	COG0441@1|root,arCOG00401@2157|Archaea,2XTFI@28890|Euryarchaeota,2N9FW@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-Thr_ED,tRNA-synt_2b,tRNA_SAD
SX3_k127_4557545_27	1144275.COCOR_02570	0.000587	53.0	COG2911@1|root,COG2911@2|Bacteria	2|Bacteria	S	protein secretion	-	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	Big_5,CHU_C,DUF642,Haemagg_act,SprB
SX3_k127_4557545_3	877455.Metbo_0742	3.804e-69	257.0	COG3356@1|root,arCOG04351@2157|Archaea,2XVEY@28890|Euryarchaeota,23NN7@183925|Methanobacteria	183925|Methanobacteria	S	Predicted membrane protein (DUF2070)	-	-	-	ko:K08979	-	-	-	-	ko00000	-	-	-	DUF2070
SX3_k127_4557545_6	673860.AciM339_0296	1.389e-63	240.0	COG1646@1|root,arCOG01085@2157|Archaea,2XTEC@28890|Euryarchaeota,3F2M3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids	pcrB	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	2.5.1.41	ko:K17104	ko00564,map00564	-	R04158	RC01091	ko00000,ko00001,ko01000	-	-	-	PcrB
SX3_k127_4557545_11	673860.AciM339_0295	1.93e-52	201.0	COG0382@1|root,arCOG00476@2157|Archaea,2XUHS@28890|Euryarchaeota,3F2N5@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	UbiA prenyltransferase family	ubiA	-	2.5.1.42	ko:K17105	ko00564,map00564	-	R04520	RC01171	ko00000,ko00001,ko01000	-	-	-	UbiA
SX3_k127_4557545_26	1455608.JDTH01000002_gene1596	3.034e-05	49.0	COG3609@1|root,arCOG01009@2157|Archaea,2XZTH@28890|Euryarchaeota,23XHR@183963|Halobacteria	183963|Halobacteria	K	transcriptional regulators containing the CopG Arc MetJ DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
SX3_k127_4557545_19	1274524.BSONL12_03219	3.128e-26	114.0	COG0490@1|root,COG0490@2|Bacteria,1V544@1239|Firmicutes,4HIGC@91061|Bacilli,1ZR77@1386|Bacillus	91061|Bacilli	P	regulatory, ligand-binding protein related to C-terminal domains of K channels	-	-	-	ko:K07228	-	-	-	-	ko00000	-	-	-	TrkA_C
SX3_k127_4557545_16	626522.GCWU000325_00504	2.473e-36	157.0	COG0475@1|root,COG0490@1|root,COG0475@2|Bacteria,COG0490@2|Bacteria,4NGF6@976|Bacteroidetes,2FNTX@200643|Bacteroidia,1WD0M@1283313|Alloprevotella	976|Bacteroidetes	P	Sodium/hydrogen exchanger family	nhaA	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_C
SX3_k127_4557545_7	485916.Dtox_1993	5.096e-63	228.0	COG0053@1|root,COG0053@2|Bacteria,1TP5C@1239|Firmicutes,24THS@186801|Clostridia,2636G@186807|Peptococcaceae	186801|Clostridia	U	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
SX3_k127_4557545_23	195250.CM001776_gene1220	4.1e-14	87.0	COG2304@1|root,COG3209@1|root,COG2304@2|Bacteria,COG3209@2|Bacteria,1GJ0D@1117|Cyanobacteria,1H29D@1129|Synechococcus	1117|Cyanobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,RHS_repeat,SdrD_B
SX3_k127_4557545_9	1089548.KI783301_gene1779	6.516e-58	231.0	COG3055@1|root,COG4412@1|root,COG5184@1|root,COG3055@2|Bacteria,COG4412@2|Bacteria,COG5184@2|Bacteria,1VW0A@1239|Firmicutes,4HWE6@91061|Bacilli,3WFP4@539002|Bacillales incertae sedis	2|Bacteria	DZ	S-layer homology domain	-	-	3.2.1.18,3.2.1.52,3.2.1.8	ko:K01181,ko:K01186,ko:K12373,ko:K20276	ko00511,ko00513,ko00520,ko00531,ko00600,ko00603,ko00604,ko01100,ko02024,ko04142,map00511,map00513,map00520,map00531,map00600,map00603,map00604,map01100,map02024,map04142	M00079	R00022,R04018,R06004,R11316	RC00028,RC00049,RC00077	ko00000,ko00001,ko00002,ko01000,ko02042,ko03110	-	GH20,GH33	-	DUF1929,DUF4347,F5_F8_type_C,FIVAR,He_PIG,HemolysinCabind,Kelch_1,Kelch_4,Laminin_G_3,SLH
SX3_k127_4557545_22	1205910.B005_5299	2.685e-14	84.0	COG0385@1|root,COG0385@2|Bacteria,2GMAM@201174|Actinobacteria	201174|Actinobacteria	S	Bile acid	-	-	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	-	SBF
SX3_k127_4557545_5	765420.OSCT_2368	2.552e-65	235.0	COG1028@1|root,COG1028@2|Bacteria,2G660@200795|Chloroflexi,376R3@32061|Chloroflexia	32061|Chloroflexia	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SX3_k127_4557545_4	247490.KSU1_A0014	1.806e-67	245.0	COG0142@1|root,COG0142@2|Bacteria,2IX56@203682|Planctomycetes	203682|Planctomycetes	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
SX3_k127_4557545_17	673860.AciM339_0628	9.456e-32	125.0	arCOG05238@1|root,arCOG05238@2157|Archaea,2Y0YG@28890|Euryarchaeota,3F3EA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4557545_1	1236689.MMALV_01670	5.472e-132	446.0	COG1199@1|root,arCOG00770@2157|Archaea,2XTH2@28890|Euryarchaeota,3F2IN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	HELICc2	rad3b	-	3.6.4.12	ko:K03722,ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD_2,HBB,Helicase_C_2,ResIII
SX3_k127_4557545_14	1054217.TALC_00178	3.06e-40	153.0	arCOG03678@1|root,arCOG03678@2157|Archaea,2XZ63@28890|Euryarchaeota,241VC@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4557545_12	439481.Aboo_1073	5.705e-52	191.0	COG0639@1|root,arCOG01143@2157|Archaea,2XUDG@28890|Euryarchaeota,3F38Q@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	Calcineurin-like phosphoesterase superfamily domain	rad24	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
SX3_k127_4557545_20	693661.Arcve_1632	1.115e-16	84.0	COG2018@1|root,arCOG02603@2157|Archaea,2XY6Z@28890|Euryarchaeota	28890|Euryarchaeota	S	Roadblock LC7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
SX3_k127_4557545_2	1150474.JQJI01000001_gene1763	3.498e-92	317.0	COG0549@1|root,COG0549@2|Bacteria,2GCB0@200918|Thermotogae	200918|Thermotogae	E	Belongs to the carbamate kinase family	-	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
SX3_k127_4557545_15	673860.AciM339_1234	6.997e-39	148.0	COG0361@1|root,arCOG01179@2157|Archaea,2XXX0@28890|Euryarchaeota,3F2RM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits	eif1a	-	-	ko:K03236	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	eIF-1a
SX3_k127_4557545_10	1094980.Mpsy_1474	5.37e-55	203.0	COG1718@1|root,arCOG01180@2157|Archaea,2XU2H@28890|Euryarchaeota,2N9ET@224756|Methanomicrobia	224756|Methanomicrobia	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
SX3_k127_4557545_13	439481.Aboo_1281	6.979e-51	190.0	COG1094@1|root,arCOG04150@2157|Archaea,2XUHX@28890|Euryarchaeota,3F2NS@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	K homology RNA-binding domain	dim2	-	-	ko:K06961	-	-	-	-	ko00000,ko03009	-	-	-	KH_1
SX3_k127_4557545_21	387631.Asulf_00714	1.251e-14	84.0	COG1917@1|root,arCOG02999@2157|Archaea	2157|Archaea	S	conserved protein, contains double-stranded beta-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SX3_k127_4557545_8	867903.ThesuDRAFT_02139	1.791e-59	230.0	COG1404@1|root,COG1404@2|Bacteria,1TQRU@1239|Firmicutes,249H1@186801|Clostridia,3WDN8@538999|Clostridiales incertae sedis	186801|Clostridia	O	Subtilase family	-	-	-	ko:K13276,ko:K17734	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	CarboxypepD_reg,Cu_amine_oxidN1,Inhibitor_I9,LRR_5,PPC,Peptidase_S8
SX3_k127_4557545_25	378806.STAUR_7660	2.335e-05	57.0	COG3693@1|root,COG3693@2|Bacteria,1Q4ED@1224|Proteobacteria,43DSU@68525|delta/epsilon subdivisions,2X8V1@28221|Deltaproteobacteria,2Z0HY@29|Myxococcales	1224|Proteobacteria	G	Glycosyl hydrolase family 10	xynA	-	3.2.1.8	ko:K01181	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_10
SX3_k127_4558987_2	673860.AciM339_0508	4.522e-129	421.0	COG0012@1|root,arCOG00357@2157|Archaea,2XTZG@28890|Euryarchaeota,3F2GD@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	GTPase of unknown function C-terminal	ychF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
SX3_k127_4558987_4	635013.TherJR_0859	2.185e-99	339.0	COG1775@1|root,COG1775@2|Bacteria,1TPEF@1239|Firmicutes,24A11@186801|Clostridia,2609U@186807|Peptococcaceae	186801|Clostridia	E	Benzoyl-CoA reductase 2-hydroxyglutaryl-CoA dehydratase subunit BcrC BadD HgdB	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
SX3_k127_4558987_15	1121035.AUCH01000023_gene3428	8.862e-25	123.0	COG0348@1|root,COG0348@2|Bacteria,1MY5M@1224|Proteobacteria,2VH7V@28216|Betaproteobacteria,2KXJC@206389|Rhodocyclales	206389|Rhodocyclales	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind,Fer4_10,Fer4_5
SX3_k127_4558987_25	1334046.AYTB01000012_gene90	1.71e-10	74.0	COG0464@1|root,COG0464@2|Bacteria,1TPQZ@1239|Firmicutes,4HCQK@91061|Bacilli,26G7I@186818|Planococcaceae	91061|Bacilli	O	Right handed beta helix region	spoVK	-	-	-	-	-	-	-	-	-	-	-	AAA,Beta_helix
SX3_k127_4558987_20	304371.MCP_0405	1.139e-15	81.0	COG2522@1|root,arCOG00017@2157|Archaea,2Y84Y@28890|Euryarchaeota,2NBJE@224756|Methanomicrobia	224756|Methanomicrobia	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K07108	-	-	-	-	ko00000	-	-	-	HTH_3
SX3_k127_4558987_14	411468.CLOSCI_02828	1.341e-25	119.0	COG0348@1|root,COG0348@2|Bacteria,1TPHF@1239|Firmicutes,247KH@186801|Clostridia,21YNG@1506553|Lachnoclostridium	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
SX3_k127_4558987_5	643562.Daes_1018	7.705e-98	334.0	COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,42PEQ@68525|delta/epsilon subdivisions,2WKWX@28221|Deltaproteobacteria,2M9FC@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
SX3_k127_4558987_18	1172190.M947_03105	1.16e-20	103.0	COG0348@1|root,COG0348@2|Bacteria,1Q4BA@1224|Proteobacteria,42Q02@68525|delta/epsilon subdivisions,2YR7B@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_10,Fer4_5
SX3_k127_4558987_21	1200567.JNKD01000002_gene2262	1.448e-14	89.0	COG0366@1|root,COG3291@1|root,COG0366@2|Bacteria,COG3291@2|Bacteria,1MU90@1224|Proteobacteria,1RQ1S@1236|Gammaproteobacteria,1Y3Q3@135624|Aeromonadales	135624|Aeromonadales	G	Alpha-amylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,CBM26,PKD
SX3_k127_4558987_10	1379698.RBG1_1C00001G0991	1.194e-39	172.0	COG2911@1|root,COG2931@1|root,COG4447@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG4447@2|Bacteria,2NR5X@2323|unclassified Bacteria	2|Bacteria	Q	FlgD Ig-like domain	-	-	3.2.1.136	ko:K15924	-	-	-	-	ko00000,ko01000	-	GH5	-	CBM_3,DUF1735,Laminin_G_3
SX3_k127_4558987_13	223926.28806624	7.58e-26	125.0	COG2304@1|root,COG2931@1|root,COG2982@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,COG2982@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,1XSBS@135623|Vibrionales	135623|Vibrionales	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin_3,He_PIG,HemolysinCabind,VWA_2
SX3_k127_4558987_7	264732.Moth_1005	2.539e-55	218.0	COG1924@1|root,COG1924@2|Bacteria,1TQSD@1239|Firmicutes,2481W@186801|Clostridia,42F39@68295|Thermoanaerobacterales	186801|Clostridia	I	PFAM ATPase, BadF BadG BcrA BcrD type	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,HGD-D
SX3_k127_4558987_6	247490.KSU1_C1240	5.919e-68	240.0	COG1924@1|root,COG1924@2|Bacteria	2|Bacteria	I	4 iron, 4 sulfur cluster binding	hgdC	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
SX3_k127_4558987_23	946362.XP_004997163.1	5.734e-11	77.0	KOG0379@1|root,KOG0379@2759|Eukaryota,39SSS@33154|Opisthokonta	33154|Opisthokonta	S	Rab9 effector protein with kelch motifs	RABEPK	GO:0000139,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005794,GO:0005802,GO:0005829,GO:0006810,GO:0006887,GO:0006897,GO:0006898,GO:0006904,GO:0008150,GO:0009987,GO:0010008,GO:0012505,GO:0016020,GO:0016192,GO:0022406,GO:0030133,GO:0031090,GO:0031410,GO:0031982,GO:0031984,GO:0032588,GO:0032940,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044431,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0046903,GO:0048278,GO:0051179,GO:0051234,GO:0051640,GO:0051641,GO:0097708,GO:0098588,GO:0098657,GO:0098791,GO:0098805,GO:0140029,GO:0140056	-	ko:K20285	-	-	-	-	ko00000,ko04131	-	-	-	Kelch_1,Kelch_2,Kelch_3,Kelch_4,Kelch_5,Kelch_6
SX3_k127_4558987_12	1521187.JPIM01000167_gene1704	5.147e-32	147.0	COG0457@1|root,COG1404@1|root,COG0457@2|Bacteria,COG1404@2|Bacteria,2G8UU@200795|Chloroflexi,3759F@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4,Kelch_5,Peptidase_S8
SX3_k127_4558987_17	443254.Marpi_1007	4.388e-22	114.0	COG1520@1|root,COG1520@2|Bacteria,2GD9T@200918|Thermotogae	200918|Thermotogae	S	PFAM Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4558987_24	525897.Dbac_0822	1.658e-10	68.0	COG4914@1|root,COG4914@2|Bacteria,1N1W1@1224|Proteobacteria,42VPD@68525|delta/epsilon subdivisions,2WS3U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4558987_0	351160.RCIX1877	6.868e-145	480.0	COG0017@1|root,arCOG00407@2157|Archaea,2XTZJ@28890|Euryarchaeota,2NBG0@224756|Methanomicrobia	224756|Methanomicrobia	J	tRNA synthetases class II (D, K and N)	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
SX3_k127_4558987_9	1303518.CCALI_02074	3.606e-47	182.0	COG0524@1|root,COG0524@2|Bacteria	2|Bacteria	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	ydjH	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
SX3_k127_4558987_1	1121430.JMLG01000002_gene1294	8.568e-139	454.0	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,247RN@186801|Clostridia,260YE@186807|Peptococcaceae	186801|Clostridia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
SX3_k127_4558987_19	439481.Aboo_1533	2.551e-16	91.0	COG1047@1|root,arCOG00981@2157|Archaea,2Y6YB@28890|Euryarchaeota,3F2VV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	-	-	-	-	-	-	-	-	-	-	FKBP_C
SX3_k127_4558987_26	673860.AciM339_0088	8.589e-07	60.0	arCOG06692@1|root,arCOG06692@2157|Archaea,2Y53M@28890|Euryarchaeota,3F3HV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4558987_3	224719.Abm4_0181	9.475e-101	341.0	COG0119@1|root,arCOG02092@2157|Archaea,2XV8D@28890|Euryarchaeota,23PFQ@183925|Methanobacteria	183925|Methanobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	aksA	-	2.3.3.14	ko:K10977	ko00300,ko00620,ko00680,ko01100,ko01120,ko01130,ko01210,ko01230,map00300,map00620,map00680,map01100,map01120,map01130,map01210,map01230	M00608	R00271,R08213,R08331,R08332	RC00004,RC00067,RC02149,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
SX3_k127_4558987_16	504728.K649_07880	1.206e-24	115.0	2BVQK@1|root,2ZT2F@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4558987_8	744872.Spica_1727	3.363e-49	184.0	COG0095@1|root,COG0095@2|Bacteria,2J7CV@203691|Spirochaetes	203691|Spirochaetes	H	Lipoate-protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
SX3_k127_4558987_22	459349.CLOAM0891	1.259e-13	86.0	COG1520@1|root,COG4412@1|root,COG1520@2|Bacteria,COG4412@2|Bacteria	2|Bacteria	S	peptidase activity, acting on L-amino acid peptides	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Big_2,HATPase_c,PQQ_2,PQQ_3,Peptidase_C25,SLH,Y_Y_Y
SX3_k127_4558987_11	1117379.BABA_22583	2.071e-34	155.0	COG4733@1|root,COG4733@2|Bacteria,1UEBB@1239|Firmicutes,4HB9W@91061|Bacilli,1ZEF1@1386|Bacillus	91061|Bacilli	S	Fibronectin type 3 domain	Tnr	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	SLH,fn3
SX3_k127_457460_7	443143.GM18_2743	3.477e-89	305.0	COG0842@1|root,COG0842@2|Bacteria,1Q99P@1224|Proteobacteria,42M53@68525|delta/epsilon subdivisions,2WMEY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
SX3_k127_457460_9	386456.JQKN01000001_gene2139	5.605e-83	286.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT1I@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SX3_k127_457460_15	439235.Dalk_2289	9.246e-42	177.0	COG3291@1|root,COG3391@1|root,COG3291@2|Bacteria,COG3391@2|Bacteria,1MWIT@1224|Proteobacteria,42W2M@68525|delta/epsilon subdivisions,2WRTW@28221|Deltaproteobacteria,2MKVR@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PKD domain	-	-	-	-	-	-	-	-	-	-	-	-	PKD,VCBS
SX3_k127_457460_8	357808.RoseRS_0104	2.225e-86	295.0	COG1446@1|root,COG1446@2|Bacteria,2G6AS@200795|Chloroflexi,37501@32061|Chloroflexia	32061|Chloroflexia	E	PFAM peptidase T2 asparaginase 2	-	-	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2
SX3_k127_457460_13	694429.Pyrfu_1410	3.33e-51	205.0	COG1042@1|root,arCOG01338@2157|Archaea,2XQ9M@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM ATP-grasp domain	-	-	6.2.1.13	ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5
SX3_k127_457460_4	156889.Mmc1_1098	7.484e-108	366.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1042 Acyl-CoA synthetase (NDP forming)	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
SX3_k127_457460_18	868131.MSWAN_2238	1.644e-35	141.0	COG0778@1|root,arCOG00288@2157|Archaea,2XZHP@28890|Euryarchaeota	28890|Euryarchaeota	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
SX3_k127_457460_14	1089551.KE386572_gene1743	4.675e-47	192.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,2U12Y@28211|Alphaproteobacteria,4BRG6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
SX3_k127_457460_1	269797.Mbar_A2752	4.942e-144	474.0	COG0072@1|root,arCOG00412@2157|Archaea,2XTD5@28890|Euryarchaeota,2N943@224756|Methanomicrobia	224756|Methanomicrobia	J	phenylalanyl-tRNA synthetase beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,tRNA-synt_2d
SX3_k127_457460_2	351160.RRC23	7.101e-142	473.0	COG0175@1|root,arCOG00073@2157|Archaea,2Y7JD@28890|Euryarchaeota,2N9AR@224756|Methanomicrobia	224756|Methanomicrobia	E	Phosphoadenosine phosphosulfate reductase family	-	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_10,PAPS_reduct
SX3_k127_457460_6	192952.MM_0299	2.693e-100	341.0	COG1208@1|root,arCOG00666@2157|Archaea,2XTK6@28890|Euryarchaeota,2NBNZ@224756|Methanomicrobia	224756|Methanomicrobia	M	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
SX3_k127_457460_0	370438.PTH_0539	1.376e-199	638.0	COG0449@1|root,COG0449@2|Bacteria,1TPGU@1239|Firmicutes,248F8@186801|Clostridia,2608Z@186807|Peptococcaceae	186801|Clostridia	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
SX3_k127_457460_16	1249627.D779_3143	2.102e-41	177.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,1RZ6G@1236|Gammaproteobacteria,1X1H2@135613|Chromatiales	135613|Chromatiales	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
SX3_k127_457460_3	273116.14325439	2.067e-118	392.0	COG1960@1|root,arCOG04310@2157|Archaea,2XXBZ@28890|Euryarchaeota,2426V@183967|Thermoplasmata	183967|Thermoplasmata	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SX3_k127_457460_17	28072.Nos7524_5484	6.723e-40	172.0	COG2304@1|root,COG3209@1|root,COG3210@1|root,COG3266@1|root,COG5276@1|root,COG2304@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,COG3266@2|Bacteria,COG5276@2|Bacteria,1G4UG@1117|Cyanobacteria	1117|Cyanobacteria	M	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,RHS_repeat
SX3_k127_457460_12	314271.RB2654_10713	1.967e-59	236.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase,Cadherin,FG-GAP,Glyco_hydro_26,HemolysinCabind,Integrin_beta,Lipase_GDSL_2
SX3_k127_457460_19	1192759.AKIB01000028_gene2028	2.992e-14	88.0	COG1572@1|root,COG1864@1|root,COG2931@1|root,COG3209@1|root,COG3210@1|root,COG3386@1|root,COG3391@1|root,COG5276@1|root,COG1572@2|Bacteria,COG1864@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,COG3386@2|Bacteria,COG3391@2|Bacteria,COG5276@2|Bacteria,1MU7T@1224|Proteobacteria,2UHRC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	FGMQ	CARDB	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,He_PIG,Laminin_G_3
SX3_k127_457460_11	314271.RB2654_10713	1.097e-73	282.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase,Cadherin,FG-GAP,Glyco_hydro_26,HemolysinCabind,Integrin_beta,Lipase_GDSL_2
SX3_k127_457460_10	1449126.JQKL01000090_gene492	2.688e-81	278.0	COG2086@1|root,COG2086@2|Bacteria,1TQA0@1239|Firmicutes,247K9@186801|Clostridia	186801|Clostridia	C	electron transfer flavoprotein	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
SX3_k127_457460_5	706587.Desti_1829	1.067e-105	355.0	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,42M3T@68525|delta/epsilon subdivisions,2WIV8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	electron transfer flavoprotein, alpha subunit	-	-	1.3.1.108	ko:K03522,ko:K22432	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	ETF,ETF_alpha
SX3_k127_457460_20	331869.BAL199_15383	3.332e-11	68.0	COG1487@1|root,COG1487@2|Bacteria,1QU3C@1224|Proteobacteria,2U72R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	vapC	-	-	-	-	-	-	-	-	-	-	-	PIN
SX3_k127_457460_21	864702.OsccyDRAFT_3826	4.664e-05	55.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria,1H8AZ@1150|Oscillatoriales	1117|Cyanobacteria	L	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
SX3_k127_4584775_2	1047013.AQSP01000144_gene855	2.553e-99	340.0	COG1232@1|root,COG1232@2|Bacteria,2NQ1W@2323|unclassified Bacteria	2|Bacteria	H	Flavin containing amine oxidoreductase	-	-	1.3.3.15,1.3.3.4,5.4.99.9	ko:K00231,ko:K01854	ko00052,ko00520,ko00860,ko01100,ko01110,map00052,map00520,map00860,map01100,map01110	M00121	R00505,R03222,R04178,R09009	RC00317,RC00885,RC02396	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase,NAD_binding_8
SX3_k127_4584775_1	697281.Mahau_2583	1.278e-104	348.0	COG1210@1|root,COG1210@2|Bacteria,1TQ24@1239|Firmicutes,25E5A@186801|Clostridia,42EY9@68295|Thermoanaerobacterales	186801|Clostridia	M	TIGRFAM UTP--glucose-1-phosphate uridylyltransferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
SX3_k127_4584775_3	1211035.CD30_13615	4.071e-41	163.0	COG1216@1|root,COG1216@2|Bacteria,1UYRR@1239|Firmicutes,4HEJ1@91061|Bacilli	91061|Bacilli	S	glycosyl transferase family 2	galnac-T15	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3,Glyco_transf_7C,Glycos_transf_2
SX3_k127_4584775_0	1041930.Mtc_1753	7.05e-119	393.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTRS@28890|Euryarchaeota,2N966@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
SX3_k127_4584775_6	1280952.HJA_04281	2.143e-06	61.0	COG1404@1|root,COG2931@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4214,HemolysinCabind,PPC,Peptidase_M10,SLH,VCBS
SX3_k127_4584775_4	215803.DB30_7108	1.128e-26	128.0	COG2885@1|root,COG2885@2|Bacteria,1MX1F@1224|Proteobacteria,43C24@68525|delta/epsilon subdivisions,2X211@28221|Deltaproteobacteria,2YX9B@29|Myxococcales	28221|Deltaproteobacteria	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
SX3_k127_4584775_5	1047013.AQSP01000052_gene2591	2.29e-08	60.0	COG1933@1|root,COG1933@2|Bacteria,2NRP4@2323|unclassified Bacteria	2|Bacteria	L	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DZR,PLDc_N,zf-ribbon_3,zinc_ribbon_2
SX3_k127_4616435_1	439481.Aboo_1173	4.528e-63	226.0	COG0171@1|root,arCOG00069@2157|Archaea,2XT7M@28890|Euryarchaeota,3F2P1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
SX3_k127_4616435_3	515635.Dtur_1801	4.28e-22	104.0	COG1913@1|root,COG1913@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
SX3_k127_4616435_0	439481.Aboo_1381	1.832e-233	771.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,3F2HY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
SX3_k127_4616435_2	439481.Aboo_1382	4.346e-43	176.0	COG1354@1|root,arCOG02610@2157|Archaea,2XZHK@28890|Euryarchaeota,3F2QG@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	chromosome segregation and condensation protein ScpA	-	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
SX3_k127_4616435_4	1041930.Mtc_1221	1.282e-17	90.0	COG1051@1|root,arCOG01075@2157|Archaea,2Y1UG@28890|Euryarchaeota	28890|Euryarchaeota	L	NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
SX3_k127_4616435_5	377629.TERTU_2658	1.91e-15	91.0	COG0747@1|root,COG1357@1|root,COG1361@1|root,COG3637@1|root,COG3897@1|root,COG4547@1|root,COG0747@2|Bacteria,COG1357@2|Bacteria,COG1361@2|Bacteria,COG3637@2|Bacteria,COG3897@2|Bacteria,COG4547@2|Bacteria,1QVSF@1224|Proteobacteria,1T46K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4624805_1	357808.RoseRS_1631	0.0004649	49.0	COG0823@1|root,COG0823@2|Bacteria,2G8Z9@200795|Chloroflexi,376BX@32061|Chloroflexia	32061|Chloroflexia	U	PFAM WD40 domain protein beta Propeller	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
SX3_k127_4624805_0	330214.NIDE3222	2.687e-80	289.0	COG0123@1|root,COG0123@2|Bacteria,3J0P2@40117|Nitrospirae	40117|Nitrospirae	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
SX3_k127_4630446_33	926560.KE387023_gene1413	7.869e-12	71.0	COG3693@1|root,COG3828@1|root,COG3693@2|Bacteria,COG3828@2|Bacteria	2|Bacteria	N	Trehalose utilisation	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM9_1,CBM_2,CBM_3,CBM_4_9,CBM_6,Glyco_hydro_10,Glyco_hydro_48,Ricin_B_lectin,VCBS,fn3
SX3_k127_4630446_9	314271.RB2654_10713	1.52e-58	233.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase,Cadherin,FG-GAP,Glyco_hydro_26,HemolysinCabind,Integrin_beta,Lipase_GDSL_2
SX3_k127_4630446_20	1121937.AUHJ01000028_gene930	1.705e-32	148.0	COG1372@1|root,COG1520@1|root,COG3209@1|root,COG1372@2|Bacteria,COG1520@2|Bacteria,COG3209@2|Bacteria,1QW4H@1224|Proteobacteria,1T42N@1236|Gammaproteobacteria,46DDZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	LM	Rhs Family	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,DUF5122,He_PIG,PT-HINT,RHS_repeat
SX3_k127_4630446_21	399741.Spro_3360	3.789e-32	139.0	COG1055@1|root,COG1055@2|Bacteria,1NEVR@1224|Proteobacteria,1RQVD@1236|Gammaproteobacteria,401TW@613|Serratia	1236|Gammaproteobacteria	P	Citrate transporter	ybiR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	CitMHS
SX3_k127_4630446_0	525904.Tter_2612	3.561e-118	400.0	COG0477@1|root,COG2814@2|Bacteria,2NQSV@2323|unclassified Bacteria	2|Bacteria	P	Fungal trichothecene efflux pump (TRI12)	mdr	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	-	-	-	-	-	-	-	-	-	MFS_1
SX3_k127_4630446_22	309801.trd_A0619	6.124e-32	140.0	COG4274@1|root,COG4274@2|Bacteria,2GBAJ@200795|Chloroflexi,27YIF@189775|Thermomicrobia	189775|Thermomicrobia	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
SX3_k127_4630446_32	1408324.JNJK01000013_gene63	1.993e-12	77.0	COG1310@1|root,COG1310@2|Bacteria,1VQJE@1239|Firmicutes,24CU8@186801|Clostridia	186801|Clostridia	S	JAB1/Mov34/MPN/PAD-1 ubiquitin protease	-	-	-	-	-	-	-	-	-	-	-	-	JAB,LysM
SX3_k127_4630446_5	644281.MFS40622_1602	3.915e-75	256.0	COG1632@1|root,arCOG04209@2157|Archaea,2XTJJ@28890|Euryarchaeota,23Q5E@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eL15 family	rpl15e	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02877	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L15e
SX3_k127_4630446_12	679926.Mpet_1394	1.861e-53	204.0	COG0241@1|root,arCOG07384@2157|Archaea,2Y0DK@28890|Euryarchaeota	28890|Euryarchaeota	E	D,D-heptose 1,7-bisphosphate phosphatase	gmhB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0034200,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	HAD_2,Hydrolase_like,PNK3P
SX3_k127_4630446_11	673860.AciM339_1397	3.924e-55	214.0	COG1051@1|root,COG2005@1|root,arCOG00223@2157|Archaea,arCOG01075@2157|Archaea,2XXS4@28890|Euryarchaeota,3F39U@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
SX3_k127_4630446_7	479434.Sthe_3269	1.589e-70	249.0	COG1230@1|root,COG1230@2|Bacteria,2G6FI@200795|Chloroflexi,27XHG@189775|Thermomicrobia	189775|Thermomicrobia	P	Cation efflux family	-	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
SX3_k127_4630446_35	1117318.PRUB_15925	1.382e-11	79.0	2DCFR@1|root,2ZDYQ@2|Bacteria,1RB5X@1224|Proteobacteria,1RN4F@1236|Gammaproteobacteria,2Q1S8@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4630446_19	264732.Moth_0241	7.914e-34	151.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	ASH,Calx-beta,DUF11,DUF1573,F5_F8_type_C,FG-GAP,Glyco_hyd_101C,Glyco_hydro_101,NPCBM_assoc,SASA
SX3_k127_4630446_23	493475.GARC_4265	1.605e-27	129.0	COG2931@1|root,COG2982@1|root,COG4733@1|root,COG2931@2|Bacteria,COG2982@2|Bacteria,COG4733@2|Bacteria,1MU7T@1224|Proteobacteria,1S1HJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Cadherin_3,DUF4214,DUF4347,He_PIG,HemolysinCabind,PATR,VCBS
SX3_k127_4630446_4	1123371.ATXH01000010_gene717	1.244e-77	276.0	COG0535@1|root,COG0535@2|Bacteria,2GI7P@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K02585	-	-	-	-	ko00000	-	-	-	Radical_SAM
SX3_k127_4630446_40	679926.Mpet_2587	8.677e-06	58.0	arCOG13108@1|root,arCOG13108@2157|Archaea,2Y5X6@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4630446_41	112098.XP_008620893.1	0.0001856	53.0	2CMFB@1|root,2QQ74@2759|Eukaryota	2759|Eukaryota	S	Galactose oxidase, central domain	lztr1	GO:0003008,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007600,GO:0008150,GO:0015030,GO:0016604,GO:0019233,GO:0031974,GO:0031981,GO:0032501,GO:0042752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0050789,GO:0050877,GO:0065007,GO:0070013	-	ko:K12115,ko:K12116,ko:K12117	ko04712,map04712	-	-	-	ko00000,ko00001,ko04121	-	-	-	BTB,F-box-like,Jacalin,Kelch_1,Kelch_2,Kelch_3,Kelch_4,PAS_9
SX3_k127_4630446_8	645991.Sgly_1017	1.326e-66	240.0	COG1924@1|root,COG1924@2|Bacteria,1TQSD@1239|Firmicutes,2481W@186801|Clostridia,261IU@186807|Peptococcaceae	186801|Clostridia	I	PFAM BadF BadG BcrA BcrD ATPase family	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
SX3_k127_4630446_13	264732.Moth_1005	1.236e-45	174.0	COG1924@1|root,COG1924@2|Bacteria,1TQSD@1239|Firmicutes,2481W@186801|Clostridia,42F39@68295|Thermoanaerobacterales	186801|Clostridia	I	PFAM ATPase, BadF BadG BcrA BcrD type	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,HGD-D
SX3_k127_4630446_2	429009.Adeg_0387	2.012e-83	293.0	COG1775@1|root,COG1775@2|Bacteria,1TPEF@1239|Firmicutes,24A11@186801|Clostridia,42F0V@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM 2-hydroxyglutaryl-CoA dehydratase D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
SX3_k127_4630446_18	663278.Ethha_1942	1.561e-34	145.0	COG0348@1|root,COG0348@2|Bacteria,1TPHF@1239|Firmicutes,247KH@186801|Clostridia,3WPQF@541000|Ruminococcaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_5,Fer4_9
SX3_k127_4630446_25	237368.SCABRO_03458	8.438e-27	125.0	COG1520@1|root,COG3391@1|root,COG1520@2|Bacteria,COG3391@2|Bacteria,2J4EP@203682|Planctomycetes	203682|Planctomycetes	S	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
SX3_k127_4630446_14	1382306.JNIM01000001_gene3428	1.2e-43	177.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria	2|Bacteria	S	anaphase-promoting complex binding	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,NACHT,Pentapeptide,Pkinase,TIR_2,WD40
SX3_k127_4630446_15	29540.C481_09243	6.821e-42	173.0	COG1520@1|root,arCOG02482@2157|Archaea,2XUI1@28890|Euryarchaeota,240TC@183963|Halobacteria	183963|Halobacteria	C	COG1520 FOG WD40-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_3
SX3_k127_4630446_3	497964.CfE428DRAFT_4943	2.268e-81	306.0	COG0577@1|root,COG0577@2|Bacteria,46U6N@74201|Verrucomicrobia	74201|Verrucomicrobia	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
SX3_k127_4630446_1	1054217.TALC_00320	2.129e-110	367.0	COG0162@1|root,arCOG01886@2157|Archaea,2XTA0@28890|Euryarchaeota,241NP@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
SX3_k127_4630446_31	745277.GRAQ_00407	1.581e-16	95.0	COG1853@1|root,COG2911@1|root,COG1853@2|Bacteria,COG2911@2|Bacteria,1P8N9@1224|Proteobacteria,1T1IH@1236|Gammaproteobacteria,3FH4B@34037|Rahnella	1236|Gammaproteobacteria	S	Bacterial Ig-like domain (group 3)	yeeJ	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Big_3_3
SX3_k127_4630446_42	118168.MC7420_5749	0.0003433	54.0	COG3420@1|root,COG3420@2|Bacteria,1G2FG@1117|Cyanobacteria,1H7WG@1150|Oscillatoriales	1117|Cyanobacteria	P	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1565,SLH
SX3_k127_4630446_38	1278073.MYSTI_05718	9.769e-09	67.0	COG0823@1|root,COG3291@1|root,COG4932@1|root,COG0823@2|Bacteria,COG3291@2|Bacteria,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria,43C2M@68525|delta/epsilon subdivisions,2X7D7@28221|Deltaproteobacteria,2Z3FP@29|Myxococcales	28221|Deltaproteobacteria	MU	PKD domain	-	-	-	-	-	-	-	-	-	-	-	-	PKD
SX3_k127_4630446_37	756883.Halar_3273	4.161e-09	68.0	COG3398@1|root,arCOG02611@2157|Archaea	2157|Archaea	K	protein conserved in archaea	gntR	-	-	ko:K07013	-	-	-	-	ko00000	-	-	-	HTH_24,HTH_5,MarR_2,V4R
SX3_k127_4630446_39	1121479.AUBS01000002_gene3634	2.462e-08	68.0	COG1652@1|root,COG4254@1|root,COG1652@2|Bacteria,COG4254@2|Bacteria,1PPWK@1224|Proteobacteria,2TYY3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR,LysM
SX3_k127_4630446_29	446465.Bfae_02880	3.64e-20	104.0	COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4FDQP@85020|Dermabacteraceae	201174|Actinobacteria	S	Laminin G domain	wcoG	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PKD
SX3_k127_4630446_34	272569.rrnAC1805	1.104e-11	77.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWHT@28890|Euryarchaeota,23V64@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	gntR	-	-	-	-	-	-	-	-	-	-	-	HTH_24,HTH_5,MarR_2
SX3_k127_4630446_16	224325.AF_0187	4.963e-38	147.0	COG2044@1|root,arCOG02066@2157|Archaea,2XWA5@28890|Euryarchaeota	28890|Euryarchaeota	O	PFAM DsrE family protein	-	GO:0008150,GO:0009987,GO:0019725,GO:0042592,GO:0048878,GO:0055082,GO:0065007,GO:0065008	-	ko:K07092	-	-	-	-	ko00000	-	-	-	DrsE,TusA
SX3_k127_4630446_26	158190.SpiGrapes_2343	3.841e-24	113.0	COG1764@1|root,COG1764@2|Bacteria	2|Bacteria	O	response to oxidative stress	ymaD	-	-	-	-	-	-	-	-	-	-	-	OsmC
SX3_k127_4630446_6	644281.MFS40622_1352	7.392e-73	251.0	COG2078@1|root,arCOG01336@2157|Archaea,2XUAP@28890|Euryarchaeota,23QUW@183939|Methanococci	183939|Methanococci	S	PFAM AMMECR1 domain protein	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
SX3_k127_4630446_24	439481.Aboo_1307	6.893e-27	118.0	arCOG05357@1|root,arCOG05357@2157|Archaea,2Y1B1@28890|Euryarchaeota,3F2VN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4630446_36	304371.MCP_0111	1.635e-11	70.0	COG1872@1|root,arCOG04058@2157|Archaea,2XZV9@28890|Euryarchaeota,2N9YJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
SX3_k127_4630446_30	439481.Aboo_1426	1.184e-17	87.0	COG1658@1|root,arCOG01486@2157|Archaea,2Y18J@28890|Euryarchaeota,3F2UV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	TOPRIM	-	-	-	-	-	-	-	-	-	-	-	-	Toprim
SX3_k127_4630446_10	1343739.PAP_08120	2.669e-57	207.0	COG2413@1|root,arCOG04066@2157|Archaea,2XSZH@28890|Euryarchaeota,24347@183968|Thermococci	183968|Thermococci	S	Nucleotidyltransferase domain	-	-	-	ko:K07073	-	-	-	-	ko00000	-	-	-	NTP_transf_2
SX3_k127_4630446_27	1094980.Mpsy_1911	7.825e-23	105.0	COG3377@1|root,arCOG04424@2157|Archaea,2Y1QZ@28890|Euryarchaeota	28890|Euryarchaeota	S	Domain of unknown function (DUF1805)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1805
SX3_k127_4630446_17	679926.Mpet_0158	2.724e-37	158.0	COG0500@1|root,arCOG04989@2157|Archaea,2Y0ZS@28890|Euryarchaeota,2N9SX@224756|Methanomicrobia	224756|Methanomicrobia	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
SX3_k127_4630446_28	383372.Rcas_3732	9.189e-21	109.0	COG1470@1|root,COG1470@2|Bacteria,2GA7Y@200795|Chloroflexi,376PQ@32061|Chloroflexia	32061|Chloroflexia	M	SMART Parallel beta-helix repeat	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NPCBM_assoc
SX3_k127_4681084_2	448385.sce4071	1.848e-99	367.0	COG2373@1|root,COG2373@2|Bacteria,1QTCC@1224|Proteobacteria,437VK@68525|delta/epsilon subdivisions,2X356@28221|Deltaproteobacteria,2YUBE@29|Myxococcales	28221|Deltaproteobacteria	S	A-macroglobulin complement component	-	-	-	-	-	-	-	-	-	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,A2M_recep,Thiol-ester_cl
SX3_k127_4681084_1	1236689.MMALV_07230	3.54e-120	398.0	COG0520@1|root,arCOG00065@2157|Archaea,2XSYI@28890|Euryarchaeota	2157|Archaea	E	Cysteine desulfurase	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
SX3_k127_4681084_0	526227.Mesil_1160	5.752e-139	457.0	COG2317@1|root,COG2317@2|Bacteria,1WIBI@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	GO:0003674,GO:0003824,GO:0004180,GO:0004181,GO:0005488,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0016787,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
SX3_k127_4681084_6	1541065.JRFE01000051_gene4925	2.846e-06	60.0	COG0467@1|root,COG0467@2|Bacteria,1G2SV@1117|Cyanobacteria,3VIJP@52604|Pleurocapsales	1117|Cyanobacteria	T	KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
SX3_k127_4681084_7	1304875.JAFZ01000001_gene824	0.0008986	51.0	COG1933@1|root,COG4260@1|root,COG1933@2|Bacteria,COG4260@2|Bacteria,3TBKD@508458|Synergistetes	508458|Synergistetes	L	SPFH domain-Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DZR,zinc_ribbon_2
SX3_k127_4681084_4	439481.Aboo_1167	7.605e-20	98.0	arCOG13554@1|root,arCOG13554@2157|Archaea,2Y74F@28890|Euryarchaeota,3F3DP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4681084_5	439481.Aboo_1166	1.608e-07	57.0	arCOG13553@1|root,arCOG13553@2157|Archaea,2Y76V@28890|Euryarchaeota,3F3HG@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4681084_3	215803.DB30_5453	4.159e-22	113.0	COG1372@1|root,COG2911@1|root,COG3209@1|root,COG3391@1|root,COG1372@2|Bacteria,COG2911@2|Bacteria,COG3209@2|Bacteria,COG3391@2|Bacteria,1PEID@1224|Proteobacteria,438II@68525|delta/epsilon subdivisions,2X3TD@28221|Deltaproteobacteria,2YX2B@29|Myxococcales	28221|Deltaproteobacteria	LM	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4735916_0	439481.Aboo_0122	6.232e-264	825.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,3F2GJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	KH domain	epf2	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_2,KH_7,Lactamase_B,Lactamase_B_6,RMMBL
SX3_k127_4739665_0	243231.GSU2789	9.632e-45	175.0	COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,1NWNJ@1224|Proteobacteria	1224|Proteobacteria	T	PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9
SX3_k127_4739665_1	443143.GM18_0068	1.198e-44	170.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42P9E@68525|delta/epsilon subdivisions,2WMH3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase HAMP	-	-	-	-	-	-	-	-	-	-	-	-	CHASE5,HAMP,HATPase_c,HisKA
SX3_k127_4773346_9	877455.Metbo_2056	2.831e-45	166.0	COG1131@1|root,arCOG00194@2157|Archaea,2XWVA@28890|Euryarchaeota	28890|Euryarchaeota	E	SMART ATPase, AAA type, core	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_4773346_7	868131.MSWAN_0582	2.776e-76	274.0	COG0842@1|root,arCOG01463@2157|Archaea,2XWB7@28890|Euryarchaeota,23PY9@183925|Methanobacteria	183925|Methanobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
SX3_k127_4773346_3	1028801.RG1141_PA11690	1.313e-90	338.0	COG3210@1|root,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,2TTVB@28211|Alphaproteobacteria,4BJ4K@82115|Rhizobiaceae	28211|Alphaproteobacteria	U	The GLUG motif	-	-	-	-	-	-	-	-	-	-	-	-	Glug,Haemagg_act
SX3_k127_4773346_8	313596.RB2501_13489	7.49e-53	215.0	COG3055@1|root,COG3291@1|root,COG3055@2|Bacteria,COG3291@2|Bacteria,4NHHD@976|Bacteroidetes,1HWPE@117743|Flavobacteriia	976|Bacteroidetes	M	Di-glucose binding within endoplasmic reticulum	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,Kelch_1,Kelch_6,Malectin,PKD
SX3_k127_4773346_6	386456.JQKN01000008_gene1390	1.479e-78	280.0	COG0420@1|root,arCOG00397@2157|Archaea,2XWH1@28890|Euryarchaeota	28890|Euryarchaeota	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity	mre11	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
SX3_k127_4773346_5	673860.AciM339_0153	3.016e-85	314.0	COG0419@1|root,arCOG00368@2157|Archaea,2XTC7@28890|Euryarchaeota,3F2VF@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	AAA domain	rad50	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_15,AAA_21,AAA_23,Rad50_zn_hook,SMC_N
SX3_k127_4773346_0	1094980.Mpsy_2852	6.492e-317	991.0	COG0188@1|root,arCOG04367@2157|Archaea,2XTZV@28890|Euryarchaeota,2N95T@224756|Methanomicrobia	224756|Methanomicrobia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
SX3_k127_4773346_13	483219.LILAB_21555	0.0004616	55.0	COG2234@1|root,COG2234@2|Bacteria,1MXJC@1224|Proteobacteria,42RKA@68525|delta/epsilon subdivisions,2WUCM@28221|Deltaproteobacteria,2YWU8@29|Myxococcales	28221|Deltaproteobacteria	S	Peptidase family M28	-	-	3.4.11.10	ko:K05994	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M28
SX3_k127_4773346_10	471854.Dfer_2050	3.272e-38	168.0	COG2831@1|root,COG2931@1|root,COG2831@2|Bacteria,COG2931@2|Bacteria,4NKIR@976|Bacteroidetes,47S7V@768503|Cytophagia	976|Bacteroidetes	Q	SMART Integrin alpha beta-propellor repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,FG-GAP,HYR,VCBS
SX3_k127_4773346_1	1449126.JQKL01000061_gene1910	7.671e-280	872.0	COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,248AV@186801|Clostridia,2682S@186813|unclassified Clostridiales	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
SX3_k127_4773346_11	1236689.MMALV_02100	3.201e-28	121.0	COG1439@1|root,arCOG00721@2157|Archaea,2XWH2@28890|Euryarchaeota,3F2SW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	V	PIN domain of ribonuclease	nob1	GO:0000469,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005575,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0030490,GO:0030684,GO:0030688,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1990904	-	ko:K07060	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN_6
SX3_k127_4773346_12	930169.B5T_00253	9.377e-08	59.0	COG0399@1|root,COG0399@2|Bacteria,1N0QW@1224|Proteobacteria,1T2H9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
SX3_k127_4773346_4	1410668.JNKC01000004_gene43	1.663e-90	302.0	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,36ES4@31979|Clostridiaceae	186801|Clostridia	V	Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
SX3_k127_4773346_2	1033810.HLPCO_001296	1.664e-110	368.0	COG4591@1|root,COG4591@2|Bacteria,2NP18@2323|unclassified Bacteria	2|Bacteria	M	ABC-type transport system involved in lipoprotein release permease component	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
SX3_k127_4789792_2	635013.TherJR_2859	9.267e-16	91.0	COG4412@1|root,COG5184@1|root,COG5492@1|root,COG4412@2|Bacteria,COG5184@2|Bacteria,COG5492@2|Bacteria,1TS5I@1239|Firmicutes,24A8Z@186801|Clostridia,261X1@186807|Peptococcaceae	186801|Clostridia	DZ	regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_2,CHB_HEX_C_1,CW_binding_2,Cu_amine_oxidN1,RCC1,RCC1_2
SX3_k127_4789792_0	1385511.N783_04790	2.961e-61	237.0	COG1404@1|root,COG1404@2|Bacteria,1UZRQ@1239|Firmicutes,4HEVW@91061|Bacilli	91061|Bacilli	O	Subtilase family	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S8,SLH
SX3_k127_4789792_3	326427.Cagg_3152	1.906e-10	75.0	COG1361@1|root,COG1470@1|root,COG1361@2|Bacteria,COG1470@2|Bacteria,2GA7Y@200795|Chloroflexi,376PQ@32061|Chloroflexia	32061|Chloroflexia	M	SMART Parallel beta-helix repeat	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NPCBM_assoc
SX3_k127_4789792_4	1254432.SCE1572_18635	0.0001377	56.0	COG1409@1|root,COG1409@2|Bacteria,1PG5U@1224|Proteobacteria,434X0@68525|delta/epsilon subdivisions,2WZ7Y@28221|Deltaproteobacteria,2Z1IU@29|Myxococcales	28221|Deltaproteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
SX3_k127_4789792_1	1459636.NTE_02241	4.005e-28	126.0	arCOG04668@1|root,arCOG04668@2157|Archaea,41SMD@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4804645_1	589924.Ferp_2333	1.444e-58	216.0	COG0437@1|root,arCOG01500@2157|Archaea	2157|Archaea	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11,Fer4_3,Fer4_4,Fer4_6
SX3_k127_4804645_2	1120998.AUFC01000005_gene693	9.978e-21	101.0	COG1014@1|root,COG1014@2|Bacteria,1V1DT@1239|Firmicutes,24HIC@186801|Clostridia	186801|Clostridia	C	indolepyruvate ferredoxin oxidoreductase beta subunit	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
SX3_k127_4804645_0	1365176.N186_05425	6.328e-148	493.0	COG4231@1|root,arCOG01609@2157|Archaea,2XPN3@28889|Crenarchaeota	28889|Crenarchaeota	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
SX3_k127_4843558_3	1347368.HG964403_gene4490	7.489e-62	243.0	COG4632@1|root,COG5492@1|root,COG4632@2|Bacteria,COG5492@2|Bacteria,1V706@1239|Firmicutes,4IQJJ@91061|Bacilli	91061|Bacilli	N	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
SX3_k127_4843558_7	471854.Dfer_1756	8.688e-05	56.0	COG1749@1|root,COG3386@1|root,COG1749@2|Bacteria,COG3386@2|Bacteria,4NTUT@976|Bacteroidetes	976|Bacteroidetes	N	Domain of unknown function (DUF4082)	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE,DUF4082
SX3_k127_4843558_8	644281.MFS40622_1482	0.0004518	52.0	arCOG07824@1|root,arCOG07824@2157|Archaea,2Y1BY@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SAP
SX3_k127_4843558_4	304371.MCP_1662	5.745e-48	181.0	COG1407@1|root,arCOG01150@2157|Archaea,2XU3W@28890|Euryarchaeota,2N9DU@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM metallophosphoesterase	-	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
SX3_k127_4843558_0	1054217.TALC_01538	2.52e-251	805.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,241ID@183967|Thermoplasmata	183967|Thermoplasmata	L	helicase superfamily c-terminal domain	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
SX3_k127_4843558_1	351160.RCIX568	2.396e-161	526.0	COG0018@1|root,arCOG00487@2157|Archaea,2XTWP@28890|Euryarchaeota,2N9C5@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
SX3_k127_4843558_5	573061.Clocel_1184	3.18e-41	177.0	COG4733@1|root,COG5492@1|root,COG4733@2|Bacteria,COG5492@2|Bacteria,1UEBB@1239|Firmicutes,24DIX@186801|Clostridia,36HNU@31979|Clostridiaceae	186801|Clostridia	N	PFAM Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4843558_6	326427.Cagg_3357	2.093e-09	72.0	COG4412@1|root,COG4412@2|Bacteria,2G622@200795|Chloroflexi,3758I@32061|Chloroflexia	32061|Chloroflexia	S	Immune inhibitor A peptidase M6	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M6
SX3_k127_4843558_2	456442.Mboo_2400	5.231e-95	322.0	COG0704@1|root,arCOG00318@2157|Archaea,2XUA4@28890|Euryarchaeota,2NADX@224756|Methanomicrobia	224756|Methanomicrobia	K	PhoU domain	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
SX3_k127_488366_0	1408473.JHXO01000015_gene1906	1.257e-44	188.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	nanA	GO:0001573,GO:0003674,GO:0003824,GO:0004308,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006672,GO:0006687,GO:0006689,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0016020,GO:0016042,GO:0016052,GO:0016787,GO:0016798,GO:0016997,GO:0019377,GO:0030149,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044424,GO:0044464,GO:0046466,GO:0046479,GO:0046514,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1903509	3.2.1.18	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	-	R04018	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33	-	BNR_2,Gram_pos_anchor,Sialidase,YSIRK_signal
SX3_k127_488366_3	349161.Dred_0966	7.569e-06	60.0	2B79F@1|root,320C5@2|Bacteria,1UV9B@1239|Firmicutes,25I7N@186801|Clostridia,266CF@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_488366_1	1347368.HG964403_gene4490	8.025e-23	116.0	COG4632@1|root,COG5492@1|root,COG4632@2|Bacteria,COG5492@2|Bacteria,1V706@1239|Firmicutes,4IQJJ@91061|Bacilli	91061|Bacilli	N	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
SX3_k127_488366_2	1121422.AUMW01000016_gene2063	3.316e-06	61.0	COG5434@1|root,COG5434@2|Bacteria,1UJS5@1239|Firmicutes,24VP2@186801|Clostridia,266SC@186807|Peptococcaceae	186801|Clostridia	M	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
SX3_k127_490433_1	1280390.CBQR020000150_gene3966	1.746e-81	281.0	COG0649@1|root,COG0649@2|Bacteria,1TQAR@1239|Firmicutes,4HA4Y@91061|Bacilli,26T7E@186822|Paenibacillaceae	91061|Bacilli	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
SX3_k127_490433_2	986075.CathTA2_2800	2.413e-75	268.0	COG1005@1|root,COG1005@2|Bacteria,1TQNU@1239|Firmicutes,4HC8R@91061|Bacilli	91061|Bacilli	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
SX3_k127_490433_4	1054217.TALC_00214	2.207e-23	116.0	COG1143@1|root,COG2768@1|root,arCOG01543@2157|Archaea,arCOG02448@2157|Archaea,2Y79M@28890|Euryarchaeota,241VP@183967|Thermoplasmata	183967|Thermoplasmata	C	4Fe-4S dicluster domain	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4_7
SX3_k127_490433_5	1128421.JAGA01000002_gene1905	1.773e-11	75.0	COG0839@1|root,COG0839@2|Bacteria,2NPUC@2323|unclassified Bacteria	2|Bacteria	C	Belongs to the complex I subunit 6 family	ndhG	-	1.6.5.3	ko:K00339,ko:K05578	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
SX3_k127_490433_3	1174504.AJTN02000207_gene3351	6.837e-24	108.0	COG0713@1|root,COG0713@2|Bacteria,1V9Z8@1239|Firmicutes,4HJ9Q@91061|Bacilli,1ZGXH@1386|Bacillus	91061|Bacilli	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
SX3_k127_490433_0	1121428.DESHY_40012___1	6.68e-150	497.0	COG1009@1|root,COG1009@2|Bacteria,1TQW4@1239|Firmicutes,24A16@186801|Clostridia,2618I@186807|Peptococcaceae	186801|Clostridia	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5	ndhF	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
SX3_k127_4924435_0	1292373.H640_04058	9.645e-15	88.0	COG1297@1|root,COG1297@2|Bacteria,2I9UD@201174|Actinobacteria	201174|Actinobacteria	S	oligopeptide transporter opt family	opt	-	-	-	-	-	-	-	-	-	-	-	OPT
SX3_k127_4928412_9	414684.RC1_3822	2.872e-36	159.0	COG3898@1|root,COG3898@2|Bacteria,1R052@1224|Proteobacteria	1224|Proteobacteria	S	HemY domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4928412_14	391613.RTM1035_19806	1.312e-13	85.0	COG0354@1|root,COG2931@1|root,COG3204@1|root,COG4932@1|root,COG0354@2|Bacteria,COG2931@2|Bacteria,COG3204@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,46P2B@74030|Roseovarius	28211|Alphaproteobacteria	MQ	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,HemolysinCabind,Laminin_G_3,PA14
SX3_k127_4928412_11	1457250.BBMO01000001_gene739	7.674e-27	117.0	COG0613@1|root,arCOG00302@2157|Archaea,2XSWE@28890|Euryarchaeota,23TEN@183963|Halobacteria	183963|Halobacteria	S	metal-dependent phosphoesterases (PHP family)	-	-	-	-	-	-	-	-	-	-	-	-	PHP,PHP_C
SX3_k127_4928412_10	1041930.Mtc_1580	4.687e-30	136.0	COG0477@1|root,arCOG00132@2157|Archaea,2XYHV@28890|Euryarchaeota,2NAK2@224756|Methanomicrobia	224756|Methanomicrobia	G	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX3_k127_4928412_0	673860.AciM339_0009	1.618e-186	599.0	COG4962@1|root,arCOG01817@2157|Archaea,2XT4E@28890|Euryarchaeota,3F2TI@33867|unclassified Euryarchaeota	28890|Euryarchaeota	N	Type II/IV secretion system protein	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
SX3_k127_4928412_2	439481.Aboo_0007	2.048e-71	254.0	COG2064@1|root,arCOG01808@2157|Archaea,2XT4Q@28890|Euryarchaeota,3F36C@33867|unclassified Euryarchaeota	28890|Euryarchaeota	N	Type II secretion system	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
SX3_k127_4928412_4	439481.Aboo_0008	2.214e-58	214.0	COG2064@1|root,arCOG01808@2157|Archaea,2XT4Q@28890|Euryarchaeota,3F37F@33867|unclassified Euryarchaeota	28890|Euryarchaeota	N	Type II secretion system	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
SX3_k127_4928412_1	439481.Aboo_0006	3.452e-177	573.0	COG4962@1|root,arCOG01817@2157|Archaea,2XT4E@28890|Euryarchaeota,3F381@33867|unclassified Euryarchaeota	28890|Euryarchaeota	N	Type II/IV secretion system protein	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
SX3_k127_4928412_12	880072.Desac_2180	4.634e-23	105.0	COG0399@1|root,COG0399@2|Bacteria,1N0QW@1224|Proteobacteria,42W70@68525|delta/epsilon subdivisions,2WRUT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM S23 ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
SX3_k127_4928412_17	1151117.AJLF01000002_gene114	4.97e-05	55.0	arCOG03799@1|root,arCOG03799@2157|Archaea,2Y3QV@28890|Euryarchaeota,244E7@183968|Thermococci	183968|Thermococci	T	Protein of unknown function (DUF835)	-	-	-	-	-	-	-	-	-	-	-	-	DUF835
SX3_k127_4928412_15	1343739.PAP_02540	1.761e-07	63.0	arCOG03797@1|root,arCOG03797@2157|Archaea,2Y8H0@28890|Euryarchaeota,24488@183968|Thermococci	183968|Thermococci	S	Protein of unknown function (DUF835)	-	-	-	-	-	-	-	-	-	-	-	-	DUF835
SX3_k127_4928412_8	1071085.KK033115_gene1998	6.529e-44	169.0	COG3359@1|root,arCOG03130@2157|Archaea,2XUES@28890|Euryarchaeota,23SXR@183963|Halobacteria	183963|Halobacteria	L	exonuclease	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
SX3_k127_4928412_3	311402.Avi_3366	1.989e-68	257.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2TQKT@28211|Alphaproteobacteria,4B7AJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	-	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
SX3_k127_4928412_7	574087.Acear_0424	5.203e-51	186.0	COG5423@1|root,COG5423@2|Bacteria	2|Bacteria	M	Predicted metal-binding protein (DUF2284)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2284
SX3_k127_4928412_13	1382306.JNIM01000001_gene3428	4.691e-21	107.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria	2|Bacteria	S	anaphase-promoting complex binding	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,NACHT,Pentapeptide,Pkinase,TIR_2,WD40
SX3_k127_4928412_16	1117314.PCIT_07767	2.718e-07	63.0	COG1404@1|root,COG5183@1|root,COG1404@2|Bacteria,COG5183@2|Bacteria,1MW57@1224|Proteobacteria,1SZIX@1236|Gammaproteobacteria,2Q5F3@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	AO	COG1404 Subtilisin-like serine proteases	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,Peptidase_S8
SX3_k127_4928412_6	1094980.Mpsy_2109	1.092e-52	191.0	COG0503@1|root,arCOG00030@2157|Archaea,2XTWM@28890|Euryarchaeota,2N9KI@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis	hpt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	iAF692.Mbar_A1633	Pribosyltran
SX3_k127_4928412_5	304371.MCP_1404	1.097e-55	215.0	COG1736@1|root,arCOG04112@2157|Archaea,2XSY5@28890|Euryarchaeota,2N9AT@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Diphthamide synthesis DPH2 protein	dph2	-	2.5.1.108	ko:K07561	-	-	R10455	RC00021,RC03180	ko00000,ko01000,ko03012	-	-	-	Diphthamide_syn
SX3_k127_4931569_2	877455.Metbo_0347	2.705e-55	207.0	COG1408@1|root,arCOG01156@2157|Archaea,2Y1DW@28890|Euryarchaeota,23PMV@183925|Methanobacteria	183925|Methanobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
SX3_k127_4931569_3	1094980.Mpsy_2165	4.075e-44	168.0	COG0432@1|root,arCOG04214@2157|Archaea,2XYW0@28890|Euryarchaeota,2N9WB@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
SX3_k127_4931569_4	523850.TON_1355	1.653e-30	137.0	COG1404@1|root,arCOG00702@2157|Archaea,2XTGN@28890|Euryarchaeota,24359@183968|Thermococci	183968|Thermococci	O	Serine protease with a broad substrate specificity	-	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005509,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0070011,GO:0071704,GO:0140096,GO:1901564	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PPC,Peptidase_S8
SX3_k127_4931569_0	673860.AciM339_0294	4.981e-93	319.0	COG2108@1|root,arCOG00932@2157|Archaea,2XU78@28890|Euryarchaeota,3F2FA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	4Fe-4S single cluster domain	-	-	-	ko:K07129	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM
SX3_k127_4931569_1	693661.Arcve_0554	1.056e-91	316.0	COG0438@1|root,arCOG01403@2157|Archaea	2157|Archaea	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
SX3_k127_4948642_1	573061.Clocel_1183	4.623e-34	151.0	COG4733@1|root,COG4733@2|Bacteria,1UEBB@1239|Firmicutes,24DIX@186801|Clostridia,36HNU@31979|Clostridiaceae	186801|Clostridia	N	PFAM Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_4948642_0	1236689.MMALV_12510	6.627e-127	419.0	COG0124@1|root,arCOG00404@2157|Archaea,2XSYX@28890|Euryarchaeota,3F2K8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the class-II aminoacyl-tRNA synthetase family	hisS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
SX3_k127_5040643_10	223926.28806624	4.094e-10	73.0	COG2304@1|root,COG2931@1|root,COG2982@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,COG2982@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,1XSBS@135623|Vibrionales	135623|Vibrionales	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin_3,He_PIG,HemolysinCabind,VWA_2
SX3_k127_5040643_12	926550.CLDAP_39050	0.000587	52.0	2DFGJ@1|root,2ZRS3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5040643_9	1454010.JEOE01000005_gene1696	4.002e-22	113.0	COG1572@1|root,COG1572@2|Bacteria,2H1Z9@201174|Actinobacteria	201174|Actinobacteria	S	CARDB	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CARDB,F5_F8_type_C,Pectate_lyase_3
SX3_k127_5040643_13	927658.AJUM01000022_gene1003	0.0009194	53.0	COG1361@1|root,COG2304@1|root,COG5184@1|root,COG1361@2|Bacteria,COG2304@2|Bacteria,COG5184@2|Bacteria,4NMB8@976|Bacteroidetes,2G13I@200643|Bacteroidia,3XJY5@558415|Marinilabiliaceae	976|Bacteroidetes	M	C-terminal domain of CHU protein family	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF11
SX3_k127_5040643_11	1379698.RBG1_1C00001G0991	1.042e-07	66.0	COG2911@1|root,COG2931@1|root,COG4447@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG4447@2|Bacteria,2NR5X@2323|unclassified Bacteria	2|Bacteria	Q	FlgD Ig-like domain	-	-	3.2.1.136	ko:K15924	-	-	-	-	ko00000,ko01000	-	GH5	-	CBM_3,DUF1735,Laminin_G_3
SX3_k127_5040643_5	573064.Mefer_0237	5.483e-78	276.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23QK4@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
SX3_k127_5040643_1	580327.Tthe_1660	8.953e-120	395.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,42FF9@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Acyl-CoA dehydrogenase	bcd	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016627,GO:0016628,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363	1.3.1.108,1.3.8.1	ko:K00248,ko:K22430	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SX3_k127_5040643_4	673860.AciM339_0622	9.431e-89	307.0	COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,3F2HI@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	PFAM Aminotransferase class I and II	aspC2	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
SX3_k127_5040643_7	1236689.MMALV_10400	1.148e-58	231.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,3F2IJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Involved in regulation of DNA replication	-	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_22
SX3_k127_5040643_0	580327.Tthe_0390	0.0	1136.0	COG0209@1|root,COG1594@1|root,COG0209@2|Bacteria,COG1594@2|Bacteria,1TPFH@1239|Firmicutes,249EN@186801|Clostridia,42F6G@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Ribonuc_red_2_N,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
SX3_k127_5040643_2	1054217.TALC_01405	1.694e-103	351.0	COG0126@1|root,arCOG00496@2157|Archaea,2XSXX@28890|Euryarchaeota,241MF@183967|Thermoplasmata	183967|Thermoplasmata	F	phosphoglycerate kinase activity	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
SX3_k127_5040643_8	673860.AciM339_0586	6.882e-55	208.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y726@28890|Euryarchaeota,3F38D@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K19576	-	-	-	-	ko00000,ko02000	2.A.1.2.10	-	-	MFS_1
SX3_k127_5040643_3	351160.RCIX2677	5.017e-98	327.0	COG2145@1|root,arCOG00019@2157|Archaea,2XSX5@28890|Euryarchaeota,2N9JX@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)	thiM	-	2.7.1.50	ko:K00878	ko00730,ko01100,map00730,map01100	M00127	R04448	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A3319	HK
SX3_k127_5040643_6	304371.MCP_1136	1.069e-72	250.0	COG0352@1|root,arCOG01089@2157|Archaea,2XSTA@28890|Euryarchaeota,2N9QV@224756|Methanomicrobia	224756|Methanomicrobia	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
SX3_k127_5083381_0	243231.GSU2073	1.586e-34	154.0	COG3209@1|root,COG3227@1|root,COG3391@1|root,COG3209@2|Bacteria,COG3227@2|Bacteria,COG3391@2|Bacteria,1QW4H@1224|Proteobacteria	1224|Proteobacteria	M	Rhs Family	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Autotransporter,Big_3_2,Big_3_5,DUF4082,DUF4347,He_PIG,PT-HINT,RHS_repeat
SX3_k127_5083381_1	329726.AM1_2999	3.548e-08	68.0	COG2885@1|root,COG2885@2|Bacteria,1G2YF@1117|Cyanobacteria	1117|Cyanobacteria	M	COGs COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)protein	-	-	-	ko:K02557,ko:K03286	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1,1.B.6	-	-	OmpA
SX3_k127_5120478_1	1094980.Mpsy_3158	3.082e-14	83.0	arCOG02911@1|root,arCOG02911@2157|Archaea,2Y0M6@28890|Euryarchaeota,2N9ZD@224756|Methanomicrobia	224756|Methanomicrobia	U	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5120478_2	192952.MM_1512	4.901e-14	85.0	arCOG02911@1|root,arCOG02911@2157|Archaea,2Y0M6@28890|Euryarchaeota,2N9ZD@224756|Methanomicrobia	224756|Methanomicrobia	U	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5120478_3	269797.Mbar_A1388	3.202e-08	65.0	arCOG02911@1|root,arCOG02911@2157|Archaea	2157|Archaea	M	toxin activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5120478_0	439481.Aboo_0945	9.771e-50	202.0	COG1470@1|root,COG1572@1|root,COG2304@1|root,arCOG02420@1|root,arCOG02081@2157|Archaea,arCOG02420@2157|Archaea,arCOG02532@2157|Archaea,arCOG02902@2157|Archaea	2157|Archaea	O	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,CARDB,CarboxypepD_reg,NPCBM_assoc,Pilin_N,VWA,VWA_2
SX3_k127_5161908_0	886293.Sinac_2657	3.862e-21	106.0	COG1657@1|root,COG1657@2|Bacteria,2IXVT@203682|Planctomycetes	203682|Planctomycetes	I	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	A2M_comp,DUF4159,Prenyltrans
SX3_k127_5161986_8	1382356.JQMP01000003_gene2033	1.083e-21	96.0	COG1804@1|root,COG1804@2|Bacteria,2GABR@200795|Chloroflexi,27XHH@189775|Thermomicrobia	189775|Thermomicrobia	C	CoA-transferase family III	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
SX3_k127_5161986_0	589924.Ferp_2331	3.469e-218	690.0	COG1884@1|root,arCOG04232@2157|Archaea,2XU3F@28890|Euryarchaeota,245QJ@183980|Archaeoglobi	2157|Archaea	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
SX3_k127_5161986_7	706587.Desti_1832	2.847e-43	163.0	COG2185@1|root,COG2185@2|Bacteria,1N56M@1224|Proteobacteria,42UGU@68525|delta/epsilon subdivisions,2WQDE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	B12 binding domain	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
SX3_k127_5161986_1	1121468.AUBR01000090_gene747	1.983e-106	359.0	COG0183@1|root,COG0183@2|Bacteria,1TT8U@1239|Firmicutes,24AD9@186801|Clostridia	186801|Clostridia	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	DUF35_N,Thiolase_C,Thiolase_N,ketoacyl-synt
SX3_k127_5161986_3	1120973.AQXL01000133_gene1707	7.543e-90	313.0	COG1545@1|root,COG3425@1|root,COG1545@2|Bacteria,COG3425@2|Bacteria,1UDNN@1239|Firmicutes	1239|Firmicutes	I	3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III_C,DUF35_N,OB_aCoA_assoc
SX3_k127_5161986_4	767817.Desgi_1150	7.578e-86	290.0	COG1028@1|root,COG1028@2|Bacteria,1TPIK@1239|Firmicutes,25073@186801|Clostridia	186801|Clostridia	IQ	Psort location Cytoplasmic, score	fabG2	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SX3_k127_5161986_6	767817.Desgi_1135	9.534e-54	193.0	COG2030@1|root,COG2030@2|Bacteria,1VE44@1239|Firmicutes,24SWZ@186801|Clostridia	186801|Clostridia	I	N-terminal half of MaoC dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
SX3_k127_5161986_2	797209.ZOD2009_04782	1.692e-92	320.0	COG3608@1|root,arCOG02890@2157|Archaea,2XV0A@28890|Euryarchaeota,23SD7@183963|Halobacteria	183963|Halobacteria	S	Succinylglutamate desuccinylase aspartoacylase	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
SX3_k127_5161986_5	1278073.MYSTI_00367	9.825e-76	260.0	COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,42NIA@68525|delta/epsilon subdivisions,2WM87@28221|Deltaproteobacteria,2YUDN@29|Myxococcales	28221|Deltaproteobacteria	HJ	Belongs to the RimK family	rimK	-	6.3.2.32	ko:K05844,ko:K14940	ko00680,ko01120,map00680,map01120	-	R09401	RC00064,RC00090	ko00000,ko00001,ko01000,ko03009	-	-	-	RimK
SX3_k127_518927_8	888743.HMPREF9141_0051	6.588e-08	65.0	COG1572@1|root,COG1572@2|Bacteria,4NDY7@976|Bacteroidetes,2FMIV@200643|Bacteroidia	976|Bacteroidetes	S	Peptidase family C25	porU	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C25
SX3_k127_518927_6	765912.Thimo_1752	3.216e-09	72.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,1RZ6G@1236|Gammaproteobacteria,1X1H2@135613|Chromatiales	135613|Chromatiales	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
SX3_k127_518927_5	643648.Slip_2147	3.977e-11	78.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	BNR_assoc_N,Beta_helix,CARDB,Calx-beta,Cleaved_Adhesin,DUF4465,Glyco_tran_WbsX,fn3
SX3_k127_518927_3	509191.AEDB02000084_gene5170	3.279e-30	141.0	COG1361@1|root,COG1470@1|root,COG2931@1|root,COG3210@1|root,COG3291@1|root,COG3391@1|root,COG4733@1|root,COG1361@2|Bacteria,COG1470@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,COG4733@2|Bacteria,1TQ2T@1239|Firmicutes,24EP0@186801|Clostridia,3WI1H@541000|Ruminococcaceae	186801|Clostridia	MU	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,PKD,Paired_CXXCH_1,SLH,fn3
SX3_k127_518927_2	1054217.TALC_00421	4.252e-36	149.0	COG0491@1|root,arCOG00504@2157|Archaea	2157|Archaea	S	COG0491 Zn-dependent hydrolases, including glyoxylases	fprA	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
SX3_k127_518927_4	1236689.MMALV_02200	7.387e-21	94.0	COG1958@1|root,arCOG00998@2157|Archaea,2Y0B2@28890|Euryarchaeota,3F2ST@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	snRNP Sm proteins	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
SX3_k127_518927_0	1094508.Tsac_0624	1.614e-68	244.0	COG1208@1|root,COG1208@2|Bacteria,1VDBC@1239|Firmicutes,24AGU@186801|Clostridia,42EZG@68295|Thermoanaerobacterales	186801|Clostridia	M	Transferase hexapeptide repeat	-	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
SX3_k127_518927_1	234267.Acid_0813	1.184e-43	177.0	COG0436@1|root,COG0436@2|Bacteria,3Y5AV@57723|Acidobacteria	57723|Acidobacteria	E	aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
SX3_k127_518927_7	368407.Memar_1272	6.079e-08	66.0	COG3398@1|root,arCOG02611@2157|Archaea	2157|Archaea	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
SX3_k127_5195626_0	679926.Mpet_0519	3.495e-87	301.0	COG2100@1|root,arCOG00951@2157|Archaea	2157|Archaea	S	SMART Elongator protein 3 MiaB NifB	-	-	2.1.1.192	ko:K06935,ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
SX3_k127_5195626_1	644281.MFS40622_0807	2.49e-58	222.0	COG1222@1|root,arCOG01306@2157|Archaea,2XTB6@28890|Euryarchaeota,23Q87@183939|Methanococci	183939|Methanococci	O	ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates	pan	GO:0000502,GO:0003674,GO:0003824,GO:0003924,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0022623,GO:0022624,GO:0030163,GO:0032991,GO:0043170,GO:0043273,GO:0043335,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	-	ko:K03420	ko03050,map03050	M00343	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA
SX3_k127_5195626_2	479435.Kfla_5110	1.977e-56	213.0	COG0638@1|root,COG0638@2|Bacteria,2GMC6@201174|Actinobacteria,4DPF1@85009|Propionibacteriales	201174|Actinobacteria	O	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine	pafA	GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170	6.3.1.19	ko:K13571	-	M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051	-	-	-	Pup_ligase
SX3_k127_5195626_4	673860.AciM339_0553	1.19e-34	133.0	COG1522@1|root,arCOG01117@2157|Archaea,2XZY2@28890|Euryarchaeota,3F3G3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
SX3_k127_5195626_5	1054217.TALC_00032	7.021e-10	64.0	arCOG15031@1|root,arCOG15031@2157|Archaea,2Y4G8@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5195626_3	1236689.MMALV_00360	1.876e-44	166.0	COG0041@1|root,arCOG02464@2157|Archaea,2XU0P@28890|Euryarchaeota,3F2PJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
SX3_k127_5214350_0	880073.Calab_2950	1.635e-247	779.0	COG0008@1|root,COG0008@2|Bacteria,2NNRW@2323|unclassified Bacteria	2|Bacteria	J	tRNA synthetases class I (E and Q), anti-codon binding domain	glnS	GO:0003674,GO:0003824,GO:0004812,GO:0004819,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006425,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECIAI39_1322.ECIAI39_0637	tRNA-synt_1c,tRNA-synt_1c_C
SX3_k127_5214350_4	1220534.B655_1216	2.187e-44	165.0	COG0864@1|root,arCOG01008@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
SX3_k127_5214350_1	880073.Calab_0341	7.04e-180	578.0	COG2986@1|root,COG2986@2|Bacteria,2NQHF@2323|unclassified Bacteria	2|Bacteria	E	Aromatic amino acid lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
SX3_k127_5214350_5	768710.DesyoDRAFT_2860	9.885e-27	114.0	COG2426@1|root,COG2426@2|Bacteria,1VCU0@1239|Firmicutes,255QH@186801|Clostridia,266N0@186807|Peptococcaceae	186801|Clostridia	S	Putative small multi-drug export protein	-	-	-	-	-	-	-	-	-	-	-	-	Sm_multidrug_ex
SX3_k127_5214350_2	868131.MSWAN_0105	4.982e-137	452.0	COG1384@1|root,arCOG00485@2157|Archaea,2XTR5@28890|Euryarchaeota,23NWD@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
SX3_k127_5214350_8	1236689.MMALV_12690	3.662e-09	60.0	COG4023@1|root,arCOG02957@2157|Archaea,2Y1AH@28890|Euryarchaeota,3F2U9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	U	but it may be involved in stabilization of the trimeric complex	secG	-	-	-	-	-	-	-	-	-	-	-	Sec61_beta
SX3_k127_5214350_3	176946.XP_007436521.1	1.978e-69	258.0	COG2304@1|root,2QPS2@2759|Eukaryota,38C6V@33154|Opisthokonta,3BE0X@33208|Metazoa,3CW49@33213|Bilateria,4803N@7711|Chordata,48YJP@7742|Vertebrata	33208|Metazoa	S	hyaluronan metabolic process	ITIH4	GO:0002526,GO:0002576,GO:0003674,GO:0004857,GO:0004866,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006810,GO:0006887,GO:0006950,GO:0006952,GO:0006953,GO:0006954,GO:0008150,GO:0009892,GO:0009987,GO:0010033,GO:0010466,GO:0010605,GO:0010951,GO:0012505,GO:0016020,GO:0016192,GO:0019222,GO:0030141,GO:0030162,GO:0030234,GO:0030414,GO:0031089,GO:0031323,GO:0031324,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0032268,GO:0032269,GO:0032940,GO:0034097,GO:0034774,GO:0042221,GO:0042827,GO:0043086,GO:0043226,GO:0043227,GO:0043229,GO:0043233,GO:0044092,GO:0044422,GO:0044424,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045861,GO:0046903,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051179,GO:0051234,GO:0051246,GO:0051248,GO:0051336,GO:0051346,GO:0052547,GO:0052548,GO:0060205,GO:0060255,GO:0061134,GO:0061135,GO:0065007,GO:0065009,GO:0070013,GO:0071944,GO:0080090,GO:0097708,GO:0098772,GO:0099503	-	-	-	-	-	-	-	-	-	-	ITI_HC_C,VIT,VWA
SX3_k127_5214350_6	289376.THEYE_A0529	1.155e-20	108.0	COG2234@1|root,COG2234@2|Bacteria,3J1BG@40117|Nitrospirae	40117|Nitrospirae	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
SX3_k127_5214350_9	377629.TERTU_3354	5.466e-05	56.0	COG1502@1|root,COG1572@1|root,COG1502@2|Bacteria,COG1572@2|Bacteria,1PCFI@1224|Proteobacteria,1SXG2@1236|Gammaproteobacteria,2PPED@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	I	CARDB	-	-	-	-	-	-	-	-	-	-	-	-	CARDB
SX3_k127_5214350_7	1451261.AS96_00415	8.574e-17	95.0	COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4FKX3@85023|Microbacteriaceae	201174|Actinobacteria	G	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	wcoG	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PKD
SX3_k127_5229293_2	1249627.D779_0950	1.396e-30	126.0	2E4R1@1|root,32ZJK@2|Bacteria,1N8FZ@1224|Proteobacteria,1S42H@1236|Gammaproteobacteria,1WYUX@135613|Chromatiales	135613|Chromatiales	S	Nitrous oxide-stimulated promoter	-	-	-	-	-	-	-	-	-	-	-	-	YgbA_NO
SX3_k127_5229293_0	264732.Moth_1893	2.395e-218	689.0	COG1866@1|root,COG1866@2|Bacteria,1TPQV@1239|Firmicutes,248JE@186801|Clostridia,42FGT@68295|Thermoanaerobacterales	186801|Clostridia	F	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
SX3_k127_5229293_3	926560.KE387023_gene3276	6.72e-23	113.0	COG2234@1|root,COG2234@2|Bacteria,1WKZ5@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PA domain	-	-	3.4.11.10,3.4.11.6	ko:K19701	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PA,Peptidase_M28
SX3_k127_5229293_4	439481.Aboo_0145	0.0007479	51.0	COG1361@1|root,arCOG02527@1|root,arCOG03553@1|root,arCOG02079@2157|Archaea,arCOG02527@2157|Archaea,arCOG03553@2157|Archaea,2Y6ZW@28890|Euryarchaeota,3F314@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	COG1361 S-layer domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5229293_1	1226325.HMPREF1548_04326	8.453e-97	332.0	COG1055@1|root,COG1055@2|Bacteria,1TPNN@1239|Firmicutes,2494X@186801|Clostridia,36WTS@31979|Clostridiaceae	186801|Clostridia	P	COG1055 Na H antiporter NhaD and related arsenite permeases	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
SX3_k127_5236001_9	404589.Anae109_2699	1.775e-05	59.0	COG0745@1|root,COG1196@1|root,COG0745@2|Bacteria,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	Response_reg
SX3_k127_5236001_2	1121468.AUBR01000012_gene2574	9.295e-61	223.0	COG2222@1|root,COG2222@2|Bacteria,1TRBS@1239|Firmicutes,24A9W@186801|Clostridia,42EVQ@68295|Thermoanaerobacterales	186801|Clostridia	G	TIGRFAM bifunctional phosphoglucose phosphomannose isomerase	-	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS,bact-PGI_C
SX3_k127_5236001_7	1297617.JPJD01000063_gene3078	3.427e-16	91.0	COG1011@1|root,COG1011@2|Bacteria,1V7T4@1239|Firmicutes,24KGC@186801|Clostridia	186801|Clostridia	S	HAD-hyrolase-like	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
SX3_k127_5236001_8	489825.LYNGBM3L_24400	8.045e-14	84.0	COG4928@1|root,COG4928@2|Bacteria,1G0KU@1117|Cyanobacteria,1H9W5@1150|Oscillatoriales	1117|Cyanobacteria	S	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	KAP_NTPase
SX3_k127_5236001_0	1009370.ALO_08133	2.409e-243	779.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,4H3M2@909932|Negativicutes	909932|Negativicutes	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
SX3_k127_5236001_5	673860.AciM339_1278	8.284e-26	119.0	COG0640@1|root,arCOG05349@2157|Archaea,2XYUG@28890|Euryarchaeota,3F2RP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_5
SX3_k127_5236001_3	673860.AciM339_1575	2.826e-39	158.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y4JI@28890|Euryarchaeota,3F328@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	DnaB-like helicase C terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
SX3_k127_5236001_6	416348.Hlac_2824	1.027e-21	112.0	COG3291@1|root,arCOG02508@2157|Archaea,2XUY6@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,PKD,Pilin_N,SdrD_B
SX3_k127_5236001_4	673860.AciM339_0974	6.416e-32	134.0	COG1310@1|root,arCOG01139@2157|Archaea,2XWKU@28890|Euryarchaeota,3F2SY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	metal-dependent protease of the PAD1 JAB1 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
SX3_k127_5236001_1	439481.Aboo_0078	9.674e-66	234.0	COG0061@1|root,arCOG01348@2157|Archaea,2XTP6@28890|Euryarchaeota,3F32I@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0017076,GO:0018130,GO:0019178,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042578,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	Inositol_P,NAD_kinase
SX3_k127_52456_1	316067.Geob_2986	2.448e-126	456.0	COG1404@1|root,COG1572@1|root,COG1404@2|Bacteria,COG1572@2|Bacteria,1REF1@1224|Proteobacteria,42RS0@68525|delta/epsilon subdivisions,2WNDK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,Peptidase_S8
SX3_k127_52456_22	929712.KI912613_gene4645	6.007e-06	59.0	COG1933@1|root,COG1933@2|Bacteria,2GU4W@201174|Actinobacteria,4CQ2Q@84995|Rubrobacteria	84995|Rubrobacteria	L	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	DZR
SX3_k127_52456_7	877455.Metbo_1145	6.42e-66	237.0	COG0467@1|root,arCOG01171@2157|Archaea,2XXJX@28890|Euryarchaeota	28890|Euryarchaeota	T	KaiC	-	-	-	ko:K07331	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	ATPase
SX3_k127_52456_11	1089553.Tph_c27240	4.672e-29	124.0	COG1051@1|root,COG1051@2|Bacteria,1VYE7@1239|Firmicutes,251KK@186801|Clostridia	186801|Clostridia	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
SX3_k127_52456_12	1236689.MMALV_01400	5.362e-25	115.0	COG1849@1|root,arCOG01224@2157|Archaea,2XYS0@28890|Euryarchaeota,3F2SZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function (DUF357)	-	-	-	ko:K09728	-	-	-	-	ko00000	-	-	-	DUF357
SX3_k127_52456_17	1121423.JONT01000012_gene469	1.166e-09	68.0	COG1246@1|root,COG1246@2|Bacteria,1V6TZ@1239|Firmicutes,24KQF@186801|Clostridia,2626A@186807|Peptococcaceae	186801|Clostridia	E	PFAM Acetyltransferase (GNAT) family	-	-	2.3.1.1	ko:K00619	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
SX3_k127_52456_0	673860.AciM339_1197	3.314e-145	480.0	COG0433@1|root,arCOG00280@2157|Archaea,2Y7MA@28890|Euryarchaeota,3F30Q@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87,HAS-barrel
SX3_k127_52456_15	572478.Vdis_2198	4.177e-18	89.0	COG0589@1|root,arCOG02053@2157|Archaea,2XQTK@28889|Crenarchaeota	28889|Crenarchaeota	T	PFAM UspA domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
SX3_k127_52456_10	926550.CLDAP_34290	5.034e-32	141.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	ASH,Big_3_2,Cadherin-like,Calx-beta,DUF11,DUF4347,DUF4430,DUF915,FTP,HYR,I-set,PQQ_2,PT-HINT,Peptidase_M36,Pro-kuma_activ,RHS_repeat,VCBS
SX3_k127_52456_8	1220534.B655_2185	6.157e-34	147.0	COG1520@1|root,arCOG02492@2157|Archaea,2Y7Q0@28890|Euryarchaeota,23PZ1@183925|Methanobacteria	183925|Methanobacteria	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_3
SX3_k127_52456_20	635013.TherJR_1425	1.715e-08	68.0	COG3005@1|root,COG4733@1|root,COG3005@2|Bacteria,COG4733@2|Bacteria,1UT1Y@1239|Firmicutes,250WR@186801|Clostridia,265BU@186807|Peptococcaceae	186801|Clostridia	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
SX3_k127_52456_14	331678.Cphamn1_1089	3.856e-19	99.0	COG0382@1|root,COG0382@2|Bacteria,1FDJU@1090|Chlorobi	1090|Chlorobi	H	TIGRFAM bacteriochlorophyll chlorophyll synthetase	-	-	2.5.1.133,2.5.1.62	ko:K04040	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06284,R09067,R11514,R11517	RC00020	ko00000,ko00001,ko01000,ko01006	-	-	-	UbiA
SX3_k127_52456_4	1054217.TALC_00158	2.032e-74	258.0	COG1100@1|root,arCOG01225@2157|Archaea,2XWN4@28890|Euryarchaeota,241NA@183967|Thermoplasmata	183967|Thermoplasmata	S	Conserved hypothetical ATP binding protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	ATP_bind_1
SX3_k127_52456_5	224325.AF_0525	4.348e-74	257.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,2463Z@183980|Archaeoglobi	183980|Archaeoglobi	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
SX3_k127_52456_21	523850.TON_0238	2.487e-08	66.0	COG2260@1|root,arCOG00906@2157|Archaea,2Y1HX@28890|Euryarchaeota,244PG@183968|Thermococci	183968|Thermococci	J	more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA	nop10	-	-	ko:K11130	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko03009,ko03032	-	-	-	Nop10p
SX3_k127_52456_2	439481.Aboo_1152	1.401e-95	319.0	COG1093@1|root,arCOG04107@2157|Archaea,2XTV0@28890|Euryarchaeota,3F2GS@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2a	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K03237	ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168	-	-	-	ko00000,ko00001,ko03012	-	-	-	EIF_2_alpha,S1
SX3_k127_52456_16	69014.TK1099	1.014e-13	78.0	COG2051@1|root,arCOG04108@2157|Archaea,2XZW2@28890|Euryarchaeota,244JK@183968|Thermococci	183968|Thermococci	J	ribosomal protein	rps27e	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02978	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S27e
SX3_k127_52456_9	673860.AciM339_1481	3.142e-32	127.0	COG1631@1|root,arCOG04109@2157|Archaea,2XXV3@28890|Euryarchaeota,3F2Q7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	binds to the 23S rRNA	rpl44e	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02929	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L44
SX3_k127_52456_3	1254432.SCE1572_28920	6.947e-82	281.0	COG0807@1|root,COG0807@2|Bacteria,1MWZR@1224|Proteobacteria,42N2Q@68525|delta/epsilon subdivisions,2X9TY@28221|Deltaproteobacteria,2YV7W@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	ribA	-	3.5.4.25	ko:K01497	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125	R00425	RC00293,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydro2
SX3_k127_52456_6	1227457.C451_06972	3.768e-66	235.0	COG0013@1|root,arCOG01254@2157|Archaea,2XTZC@28890|Euryarchaeota,23UTP@183963|Halobacteria	183963|Halobacteria	J	metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain	-	-	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
SX3_k127_52456_19	28072.Nos7524_4621	6.052e-09	70.0	COG0823@1|root,COG2304@1|root,COG3209@1|root,COG3210@1|root,COG0823@2|Bacteria,COG2304@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,1GQ0G@1117|Cyanobacteria,1HN8U@1161|Nostocales	1117|Cyanobacteria	MU	Dystroglycan-type cadherin-like domains.	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,He_PIG,RHS_repeat
SX3_k127_52456_18	449447.MAE_21930	2.648e-09	71.0	2DU7S@1|root,33P96@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_52456_13	1094980.Mpsy_1184	6.095e-20	106.0	arCOG02538@1|root,arCOG02544@1|root,arCOG06534@1|root,arCOG02538@2157|Archaea,arCOG02544@2157|Archaea,arCOG06534@2157|Archaea,2Y6ZG@28890|Euryarchaeota,2NAWQ@224756|Methanomicrobia	2157|Archaea	S	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,He_PIG,NosD,PKD,PQQ_3,Peptidase_S8,S-layer
SX3_k127_526459_1	593750.Metfor_1649	1.71e-195	670.0	COG0457@1|root,arCOG03042@1|root,arCOG03032@2157|Archaea,arCOG03038@2157|Archaea,arCOG03042@2157|Archaea,2XUNW@28890|Euryarchaeota,2NAN4@224756|Methanomicrobia	224756|Methanomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
SX3_k127_526459_7	273116.14325711	1.278e-13	72.0	arCOG05337@1|root,arCOG05337@2157|Archaea,2Y4WJ@28890|Euryarchaeota,242BU@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_526459_10	673860.AciM339_0628	6.689e-05	49.0	arCOG05238@1|root,arCOG05238@2157|Archaea,2Y0YG@28890|Euryarchaeota,3F3EA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_526459_0	635013.TherJR_1489	2.12e-281	889.0	COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,248GI@186801|Clostridia,260PA@186807|Peptococcaceae	186801|Clostridia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
SX3_k127_526459_2	269799.Gmet_2053	4.064e-116	421.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,42MFX@68525|delta/epsilon subdivisions,2WJ91@28221|Deltaproteobacteria,43T6C@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
SX3_k127_526459_5	673860.AciM339_0952	2.866e-32	132.0	COG1591@1|root,arCOG00919@2157|Archaea,2XY2Q@28890|Euryarchaeota,3F2NJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Archaeal holliday junction resolvase (hjc)	-	-	-	-	-	-	-	-	-	-	-	-	Hjc
SX3_k127_526459_9	593750.Metfor_1934	1.565e-07	64.0	COG2319@1|root,arCOG02491@2157|Archaea	2157|Archaea	L	WD-40 repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
SX3_k127_526459_11	324602.Caur_0392	0.0001846	53.0	COG1361@1|root,COG1470@1|root,COG1361@2|Bacteria,COG1470@2|Bacteria,2GA7Y@200795|Chloroflexi,376PQ@32061|Chloroflexia	32061|Chloroflexia	M	SMART Parallel beta-helix repeat	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NPCBM_assoc
SX3_k127_526459_3	1121430.JMLG01000003_gene564	4.238e-99	338.0	COG1570@1|root,COG1570@2|Bacteria,1TP4E@1239|Firmicutes,247KE@186801|Clostridia,26022@186807|Peptococcaceae	186801|Clostridia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
SX3_k127_526459_8	1218173.BALCAV_0207650	4.318e-09	69.0	COG1722@1|root,COG1722@2|Bacteria,1VK9I@1239|Firmicutes,4HNRB@91061|Bacilli,1ZIVS@1386|Bacillus	91061|Bacilli	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
SX3_k127_526459_6	304371.MCP_0982	2.317e-18	100.0	COG2319@1|root,arCOG02491@2157|Archaea,2Y226@28890|Euryarchaeota,2NB3Y@224756|Methanomicrobia	224756|Methanomicrobia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
SX3_k127_526459_4	661478.OP10G_2309	6.136e-70	242.0	COG1131@1|root,COG1131@2|Bacteria	2|Bacteria	V	ATPase activity	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_5276054_3	1089455.MOPEL_084_00140	6.748e-08	59.0	COG2246@1|root,COG2246@2|Bacteria,2I9SF@201174|Actinobacteria,4F80D@85018|Dermatophilaceae	201174|Actinobacteria	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
SX3_k127_5276054_1	56780.SYN_02389	1.042e-24	121.0	COG1807@1|root,COG1807@2|Bacteria,1P6JE@1224|Proteobacteria,42QEZ@68525|delta/epsilon subdivisions,2WKYB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
SX3_k127_5276054_0	439481.Aboo_0478	1.151e-70	246.0	COG1136@1|root,arCOG00922@2157|Archaea,2XUH3@28890|Euryarchaeota,3F2R8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	ABC transporter	yvrO-2	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_5276054_5	1121937.AUHJ01000009_gene1498	0.0001922	55.0	COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,1RZZ8@1236|Gammaproteobacteria,46ASJ@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	MacB-like periplasmic core domain	VPA0017	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SX3_k127_5276054_4	649638.Trad_0681	3.984e-07	63.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	3.1.4.46,3.2.1.8	ko:K01126,ko:K01181	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	LRR_5,Laminin_G_3,NLPC_P60,PKD,Reprolysin_4,fn3
SX3_k127_5276054_2	715226.ABI_39890	1.46e-12	81.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HCBP_related,HemolysinCabind,Peptidase_M10_C
SX3_k127_5302353_0	679926.Mpet_2506	1.81e-11	74.0	COG3398@1|root,arCOG02611@2157|Archaea	2157|Archaea	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
SX3_k127_5314815_9	439481.Aboo_0314	2.244e-17	85.0	COG0750@1|root,arCOG04064@2157|Archaea,2XSZP@28890|Euryarchaeota,3F2KK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M50
SX3_k127_5314815_2	439481.Aboo_0908	7.623e-69	239.0	COG1859@1|root,arCOG04063@2157|Archaea,2XWPC@28890|Euryarchaeota,3F2KG@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase	kptA	-	-	ko:K07559	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PTS_2-RNA
SX3_k127_5314815_5	941449.dsx2_1090	6.344e-42	169.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,42WCU@68525|delta/epsilon subdivisions,2X5FB@28221|Deltaproteobacteria,2MGD0@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5314815_6	192952.MM_2015	1.4e-26	115.0	COG1308@1|root,arCOG04061@2157|Archaea,2XXYV@28890|Euryarchaeota,2NA0G@224756|Methanomicrobia	224756|Methanomicrobia	J	Contacts the emerging nascent chain on the ribosome	nac	-	-	ko:K03626	-	-	-	-	ko00000	-	-	-	NAC
SX3_k127_5314815_3	304371.MCP_1766	1.772e-61	231.0	arCOG04521@1|root,arCOG04521@2157|Archaea,2XUMG@28890|Euryarchaeota,2NAW2@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5314815_0	1041930.Mtc_1663	2.538e-79	272.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT2Y@28890|Euryarchaeota,2N9GE@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_5314815_7	439481.Aboo_0620	2.195e-22	113.0	arCOG02497@1|root,arCOG02497@2157|Archaea	2157|Archaea	P	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,DUF11,NosD
SX3_k127_5314815_8	1499967.BAYZ01000080_gene926	6.88e-19	102.0	COG2234@1|root,COG2234@2|Bacteria,2NQ2F@2323|unclassified Bacteria	2|Bacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
SX3_k127_5314815_4	886377.Murru_2329	4.714e-44	184.0	COG3055@1|root,COG3291@1|root,COG3055@2|Bacteria,COG3291@2|Bacteria,4NHHD@976|Bacteroidetes,1HWPE@117743|Flavobacteriia	976|Bacteroidetes	M	Di-glucose binding within endoplasmic reticulum	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,Kelch_1,Kelch_6,Malectin,PKD
SX3_k127_53184_0	673860.AciM339_0842	3.986e-69	246.0	COG0462@1|root,arCOG00067@2157|Archaea,2XTA8@28890|Euryarchaeota,3F2FN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
SX3_k127_53184_1	635013.TherJR_0273	1.714e-62	223.0	COG0566@1|root,COG0566@2|Bacteria,1TP9G@1239|Firmicutes,247SC@186801|Clostridia,2602K@186807|Peptococcaceae	186801|Clostridia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	yacO	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
SX3_k127_53184_2	693661.Arcve_1811	3.185e-48	180.0	COG0310@1|root,arCOG02248@2157|Archaea,2XU97@28890|Euryarchaeota,2462C@183980|Archaeoglobi	183980|Archaeoglobi	P	Cobalamin (Vitamin B12) biosynthesis CbiM protein	-	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM
SX3_k127_5326611_1	754477.Q7C_2585	6.038e-30	138.0	COG0689@1|root,COG2931@1|root,COG0689@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,460U8@72273|Thiotrichales	72273|Thiotrichales	Q	PFAM Hemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HCBP_related,He_PIG,HemolysinCabind
SX3_k127_5326611_0	1054217.TALC_00534	8.335e-102	349.0	COG0068@1|root,arCOG01187@2157|Archaea,2XTHZ@28890|Euryarchaeota	28890|Euryarchaeota	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Peptidase_M22,Sua5_yciO_yrdC,zf-HYPF
SX3_k127_5362572_1	349521.HCH_01321	8.987e-18	98.0	COG1075@1|root,COG1075@2|Bacteria,1N2AK@1224|Proteobacteria,1S99T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	ASH,DUF915
SX3_k127_5362572_2	1343739.PAP_07285	2.422e-13	83.0	arCOG04615@1|root,arCOG04615@2157|Archaea,2Y2IE@28890|Euryarchaeota,244Z1@183968|Thermococci	183968|Thermococci	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
SX3_k127_5362572_0	589924.Ferp_0541	6.478e-35	139.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,246Q2@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator, ArsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
SX3_k127_5362572_3	290397.Adeh_3524	1.662e-05	58.0	COG1404@1|root,COG1572@1|root,COG1404@2|Bacteria,COG1572@2|Bacteria,1REF1@1224|Proteobacteria,42RS0@68525|delta/epsilon subdivisions,2WNDK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,Peptidase_S8
SX3_k127_5400762_0	2074.JNYD01000002_gene5790	6.832e-56	210.0	COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,2HE4H@201174|Actinobacteria	201174|Actinobacteria	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
SX3_k127_5400762_1	373903.Hore_08450	5.485e-20	106.0	COG1033@1|root,COG1033@2|Bacteria,1VSWA@1239|Firmicutes,247R6@186801|Clostridia,3WB6E@53433|Halanaerobiales	186801|Clostridia	S	hydrophobe amphiphile efflux-3 (HAE3) family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
SX3_k127_5404849_0	189425.PGRAT_11010	3.126e-55	200.0	COG0716@1|root,COG0716@2|Bacteria,1TYNY@1239|Firmicutes,4I7TI@91061|Bacilli,26XF6@186822|Paenibacillaceae	91061|Bacilli	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5404849_1	304371.MCP_2185	6.037e-33	143.0	COG0716@1|root,arCOG00519@2157|Archaea,2XZ4A@28890|Euryarchaeota	28890|Euryarchaeota	K	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,Flavodoxin_4,HTH_5
SX3_k127_5404849_2	1283287.KB822580_gene1848	9.651e-07	52.0	COG0042@1|root,COG0042@2|Bacteria,2GJ8I@201174|Actinobacteria,4DNZA@85009|Propionibacteriales	201174|Actinobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	GO:0008150,GO:0010565,GO:0019216,GO:0019217,GO:0019222,GO:0031323,GO:0050789,GO:0050794,GO:0062012,GO:0065007,GO:0080090	-	-	-	-	-	-	-	-	-	-	Dus
SX3_k127_5409669_2	1340434.AXVA01000010_gene5421	6.372e-16	78.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4HABI@91061|Bacilli,1ZB0F@1386|Bacillus	91061|Bacilli	C	acyl-CoA transferases carnitine dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
SX3_k127_5409669_0	1459636.NTE_00007	2.925e-109	385.0	COG0417@1|root,arCOG00329@2157|Archaea	2157|Archaea	L	DNA polymerase elongation subunit (Family B)	polB2	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B
SX3_k127_5409669_1	1041930.Mtc_0010	4.34e-101	338.0	COG0379@1|root,arCOG04459@2157|Archaea,2XUGT@28890|Euryarchaeota,2N922@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
SX3_k127_5409669_3	1410630.JNKP01000005_gene814	7.49e-07	60.0	COG1073@1|root,COG1073@2|Bacteria,1TQYU@1239|Firmicutes,24AH0@186801|Clostridia,27TGV@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Alpha/beta hydrolase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_4,Hydrolase_4
SX3_k127_5467362_3	673860.AciM339_0759	5.633e-62	227.0	COG1468@1|root,arCOG00786@2157|Archaea,2Y71A@28890|Euryarchaeota,3F34X@33867|unclassified Euryarchaeota	28890|Euryarchaeota	V	TIGRFAM CRISPR-associated protein Cas4	-	-	3.1.12.1	ko:K07464	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PDDEXK_1
SX3_k127_5467362_5	1295642.H839_15477	4.039e-41	157.0	COG0509@1|root,COG0509@2|Bacteria,1V6WV@1239|Firmicutes,4HIMA@91061|Bacilli,1WGDI@129337|Geobacillus	91061|Bacilli	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
SX3_k127_5467362_1	579137.Metvu_1011	8.02e-89	302.0	COG0167@1|root,arCOG00603@2157|Archaea,2XTMB@28890|Euryarchaeota,23QC5@183939|Methanococci	183939|Methanococci	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
SX3_k127_5467362_2	439481.Aboo_0831	7.152e-71	248.0	COG0543@1|root,arCOG02199@2157|Archaea,2XSY9@28890|Euryarchaeota,3F2KR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
SX3_k127_5467362_4	679926.Mpet_0674	1.638e-46	182.0	COG1041@1|root,arCOG00047@2157|Archaea,2XTD6@28890|Euryarchaeota,2N9HA@224756|Methanomicrobia	224756|Methanomicrobia	Q	RNA methylase	trmL	-	2.1.1.213	ko:K07446	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP,UPF0020
SX3_k127_5467362_6	679926.Mpet_0188	9.978e-31	123.0	COG0760@1|root,arCOG07441@2157|Archaea,2Y0XR@28890|Euryarchaeota	28890|Euryarchaeota	O	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3
SX3_k127_5467362_7	671065.MetMK1DRAFT_00032870	1.857e-08	63.0	COG2402@1|root,arCOG04502@2157|Archaea,2XSKX@28889|Crenarchaeota	28889|Crenarchaeota	V	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07065	-	-	-	-	ko00000	-	-	-	PIN
SX3_k127_5467362_0	706587.Desti_0010	9.649e-196	619.0	COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1QUMN@1224|Proteobacteria,43BMA@68525|delta/epsilon subdivisions,2X6ZG@28221|Deltaproteobacteria,2MR5E@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NAD(P)-binding Rossmann-like domain	hdrA	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,FlpD,Pyr_redox_2
SX3_k127_5478296_3	439481.Aboo_0341	1.698e-31	128.0	COG1656@1|root,arCOG04290@2157|Archaea,2XXTT@28890|Euryarchaeota,3F3CD@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C
SX3_k127_5478296_2	439481.Aboo_0416	2.661e-50	186.0	COG1985@1|root,arCOG01484@2157|Archaea,2XU47@28890|Euryarchaeota,3F2MK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	RibD C-terminal domain	ribG	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009451,GO:0009987,GO:0016070,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0034641,GO:0036094,GO:0042364,GO:0042726,GO:0042727,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.1.1.302	ko:K14654	ko00740,ko01100,map00740,map01100	-	R09375,R09376	RC00933	ko00000,ko00001,ko01000	-	-	-	RibD_C
SX3_k127_5478296_1	673860.AciM339_0285	1.284e-64	231.0	COG1938@1|root,arCOG00347@2157|Archaea,2XT93@28890|Euryarchaeota,3F2T7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
SX3_k127_5478296_0	589924.Ferp_0980	3.938e-192	640.0	COG1241@1|root,arCOG03146@1|root,arCOG00439@2157|Archaea,arCOG03146@2157|Archaea,2XT5D@28890|Euryarchaeota,246MK@183980|Archaeoglobi	183980|Archaeoglobi	L	Mcm family	-	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	HTH_3,Intein_splicing,LAGLIDADG_3,MCM,MCM_OB
SX3_k127_5478296_4	246969.TAM4_1004	1.424e-23	107.0	COG2412@1|root,arCOG04051@2157|Archaea,2XYQK@28890|Euryarchaeota,244B2@183968|Thermococci	183968|Thermococci	S	Protein of unknown function (DUF424)	-	-	-	ko:K09148	-	-	-	-	ko00000	-	-	-	DUF424
SX3_k127_5478296_5	877455.Metbo_0527	2.932e-10	71.0	COG1499@1|root,arCOG04149@2157|Archaea,2XUAI@28890|Euryarchaeota,23NXE@183925|Methanobacteria	183925|Methanobacteria	J	NMD3 family	-	-	-	ko:K07562	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko03009	-	-	-	NMD3
SX3_k127_5484437_1	673860.AciM339_0030	5.088e-64	227.0	COG2220@1|root,arCOG00497@2157|Archaea,2XZBG@28890|Euryarchaeota,3F2Q1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
SX3_k127_5484437_0	304371.MCP_0109	1.232e-86	303.0	COG0044@1|root,arCOG00689@2157|Archaea,2XTQU@28890|Euryarchaeota,2N9BT@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
SX3_k127_5484437_5	673860.AciM339_1005	7.01e-25	109.0	arCOG05517@1|root,arCOG05517@2157|Archaea,2Y72T@28890|Euryarchaeota,3F3AH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5484437_7	1122604.JONR01000045_gene2505	2.242e-10	73.0	COG5513@1|root,COG5513@2|Bacteria,1Q83Y@1224|Proteobacteria,1TAXG@1236|Gammaproteobacteria,1X93Q@135614|Xanthomonadales	135614|Xanthomonadales	S	Chagasin family peptidase inhibitor I42	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I42
SX3_k127_5484437_6	387631.Asulf_01213	2.321e-21	106.0	COG0727@1|root,arCOG02579@2157|Archaea,2Y1J3@28890|Euryarchaeota	28890|Euryarchaeota	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
SX3_k127_5484437_3	1054217.TALC_01127	9.412e-40	160.0	COG0717@1|root,arCOG04048@2157|Archaea,2Y6CE@28890|Euryarchaeota,241VF@183967|Thermoplasmata	183967|Thermoplasmata	F	dUTPase	-	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
SX3_k127_5484437_2	391623.TERMP_00041	6.824e-53	196.0	COG1756@1|root,arCOG04122@2157|Archaea,2XX9G@28890|Euryarchaeota,243H9@183968|Thermococci	183968|Thermococci	J	Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA	nep1	GO:0000154,GO:0000462,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019843,GO:0022613,GO:0030490,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070037,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363	2.1.1.260	ko:K14568	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009	-	-	-	EMG1
SX3_k127_5484437_4	867845.KI911784_gene1447	2.928e-36	145.0	COG1100@1|root,COG1100@2|Bacteria,2G9IC@200795|Chloroflexi,3777W@32061|Chloroflexia	32061|Chloroflexia	S	SMART Ras small GTPase, Ras type	-	-	-	-	-	-	-	-	-	-	-	-	Ras
SX3_k127_549007_2	485918.Cpin_4113	6.355e-20	106.0	COG2911@1|root,COG2911@2|Bacteria,4NHHA@976|Bacteroidetes,1IVM6@117747|Sphingobacteriia	976|Bacteroidetes	M	Domain of unknown function	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_4,CHU_C,Calx-beta,He_PIG,NHL,TIG
SX3_k127_549007_3	76636.JOEC01000002_gene2862	2.768e-13	84.0	COG2931@1|root,COG2931@2|Bacteria,2ICU9@201174|Actinobacteria,4FMQX@85023|Microbacteriaceae	201174|Actinobacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_549007_1	383372.Rcas_3603	1.216e-33	141.0	COG1100@1|root,COG1100@2|Bacteria,2G9IC@200795|Chloroflexi,3777W@32061|Chloroflexia	32061|Chloroflexia	S	SMART Ras small GTPase, Ras type	-	-	-	-	-	-	-	-	-	-	-	-	Ras
SX3_k127_549007_0	1121428.DESHY_60369___1	6.006e-170	551.0	COG0519@1|root,COG0519@2|Bacteria,1TPG8@1239|Firmicutes,2487F@186801|Clostridia,26041@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans
SX3_k127_549007_4	765420.OSCT_0859	2.15e-07	66.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
SX3_k127_5524786_4	373903.Hore_16210	6.536e-117	398.0	COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,3WAG5@53433|Halanaerobiales	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
SX3_k127_5524786_0	203119.Cthe_0311	0.0	1160.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,3WGS6@541000|Ruminococcaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
SX3_k127_5524786_1	580331.Thit_1771	1.284e-241	766.0	COG0556@1|root,COG0556@2|Bacteria,1TPKB@1239|Firmicutes,247P7@186801|Clostridia,42F1Y@68295|Thermoanaerobacterales	186801|Clostridia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
SX3_k127_5524786_5	673860.AciM339_0550	4.509e-57	209.0	COG1303@1|root,arCOG01857@2157|Archaea,2XV35@28890|Euryarchaeota,3F2NN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs	trm56	GO:0001510,GO:0002128,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.206	ko:K07254	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Trm56
SX3_k127_5524786_7	273075.Ta0931	2.644e-41	159.0	COG1303@1|root,arCOG01857@2157|Archaea,2XV35@28890|Euryarchaeota,241PF@183967|Thermoplasmata	183967|Thermoplasmata	J	Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs	-	-	2.1.1.206	ko:K07254	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	HD,Trm56
SX3_k127_5524786_8	768710.DesyoDRAFT_3380	5.223e-30	128.0	COG1410@1|root,COG1410@2|Bacteria,1V0F4@1239|Firmicutes,25CEI@186801|Clostridia,260JU@186807|Peptococcaceae	186801|Clostridia	E	PFAM Pterin binding enzyme	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
SX3_k127_5524786_3	631362.Thi970DRAFT_04814	1.237e-139	458.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,1RP5K@1236|Gammaproteobacteria,1WW6E@135613|Chromatiales	135613|Chromatiales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
SX3_k127_5524786_10	498761.HM1_2986	5.691e-15	87.0	COG1266@1|root,COG1266@2|Bacteria,1V4WD@1239|Firmicutes,24P4C@186801|Clostridia	186801|Clostridia	S	PFAM CAAX amino terminal protease family	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
SX3_k127_5524786_6	269799.Gmet_0933	1.271e-41	169.0	COG2304@1|root,COG2373@1|root,COG3391@1|root,COG2304@2|Bacteria,COG2373@2|Bacteria,COG3391@2|Bacteria,1QU09@1224|Proteobacteria	1224|Proteobacteria	M	regulator of chromosome condensation, RCC1	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,Cadherin,He_PIG,RHS_repeat
SX3_k127_5524786_2	204669.Acid345_2237	5.709e-223	711.0	COG0021@1|root,COG0021@2|Bacteria	2|Bacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
SX3_k127_5524786_9	765913.ThidrDRAFT_1810	1.057e-26	124.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,1RZ6G@1236|Gammaproteobacteria,1X1H2@135613|Chromatiales	135613|Chromatiales	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
SX3_k127_5537743_4	521045.Kole_0088	5.118e-44	167.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	PRiA4_ORF3
SX3_k127_5537743_10	1293048.CBMB010000004_gene1688	6.959e-18	98.0	COG0640@1|root,arCOG00731@2157|Archaea,2XYSK@28890|Euryarchaeota,23XBH@183963|Halobacteria	183963|Halobacteria	K	Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
SX3_k127_5537743_5	99598.Cal7507_2221	4.06e-42	175.0	COG0517@1|root,COG0784@1|root,COG2202@1|root,COG4191@1|root,COG0517@2|Bacteria,COG0784@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,1G1PE@1117|Cyanobacteria,1HM9U@1161|Nostocales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg
SX3_k127_5537743_12	1047013.AQSP01000052_gene2591	2.076e-07	56.0	COG1933@1|root,COG1933@2|Bacteria,2NRP4@2323|unclassified Bacteria	2|Bacteria	L	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DZR,PLDc_N,zf-ribbon_3,zinc_ribbon_2
SX3_k127_5537743_13	589924.Ferp_1371	1.053e-06	54.0	arCOG03911@1|root,arCOG03911@2157|Archaea,2XZ41@28890|Euryarchaeota,246EY@183980|Archaeoglobi	183980|Archaeoglobi	S	Short C-terminal domain	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
SX3_k127_5537743_8	351160.RCIX240	1.045e-24	114.0	arCOG01190@1|root,arCOG01190@2157|Archaea,2XV67@28890|Euryarchaeota	28890|Euryarchaeota	T	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	RIO1
SX3_k127_5537743_9	1459636.NTE_01116	1.682e-22	101.0	arCOG03769@1|root,arCOG03769@2157|Archaea	2157|Archaea	M	glucosylceramidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5537743_2	457570.Nther_0295	6.438e-88	312.0	COG0661@1|root,COG0661@2|Bacteria,1TPIV@1239|Firmicutes,2494Y@186801|Clostridia	186801|Clostridia	S	pfam abc-1	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,APH,Pkinase
SX3_k127_5537743_1	351160.RCIX2025	1.889e-90	323.0	COG1269@1|root,arCOG04138@2157|Archaea,2XTQP@28890|Euryarchaeota,2N9EB@224756|Methanomicrobia	224756|Methanomicrobia	C	Belongs to the V-ATPase 116 kDa subunit family	atpI-1	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
SX3_k127_5537743_11	1041930.Mtc_1400	1.809e-14	76.0	COG0636@1|root,arCOG02455@2157|Archaea,2XZRP@28890|Euryarchaeota,2N9ZA@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM H transporting two-sector ATPase C subunit	atpK-1	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	iAF692.Mbar_A0390	ATP-synt_C
SX3_k127_5537743_6	1094980.Mpsy_2503	2.056e-29	124.0	COG1390@1|root,arCOG00869@2157|Archaea,2XWGX@28890|Euryarchaeota,2N9TB@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
SX3_k127_5537743_3	1041930.Mtc_1398	4.796e-82	285.0	COG1527@1|root,arCOG02459@2157|Archaea,2XTK5@28890|Euryarchaeota,2N9HH@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	iAF692.Mbar_A0388	vATP-synt_AC39
SX3_k127_5537743_7	1094980.Mpsy_2505	5.355e-26	109.0	COG1436@1|root,arCOG04102@2157|Archaea,2XXYI@28890|Euryarchaeota,2N9YY@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
SX3_k127_5537743_0	351160.RCIX2030	4.35e-129	417.0	COG1155@1|root,arCOG00868@2157|Archaea,2XT8I@28890|Euryarchaeota,2N93M@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
SX3_k127_5617835_5	523841.HFX_2520	0.0009656	49.0	COG1522@1|root,arCOG01580@2157|Archaea,2XX5M@28890|Euryarchaeota,23VKV@183963|Halobacteria	183963|Halobacteria	K	COG1522 Transcriptional regulators	trh3	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_AsnC-type
SX3_k127_5617835_3	134676.ACPL_2813	4.483e-08	64.0	COG1522@1|root,COG1522@2|Bacteria,2GK3G@201174|Actinobacteria,4DCQ2@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix ASNC type	lrp_3	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
SX3_k127_5617835_1	304371.MCP_2185	1.179e-31	130.0	COG0716@1|root,arCOG00519@2157|Archaea,2XZ4A@28890|Euryarchaeota	28890|Euryarchaeota	K	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,Flavodoxin_4,HTH_5
SX3_k127_5617835_2	357808.RoseRS_0451	5.859e-21	101.0	2CH44@1|root,32S57@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5617835_0	304371.MCP_2185	1.021e-31	131.0	COG0716@1|root,arCOG00519@2157|Archaea,2XZ4A@28890|Euryarchaeota	28890|Euryarchaeota	K	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,Flavodoxin_4,HTH_5
SX3_k127_5617835_4	431947.PGN_1224	4.603e-05	55.0	COG1522@1|root,COG1522@2|Bacteria,4NMEN@976|Bacteroidetes,2FMP2@200643|Bacteroidia,22XKX@171551|Porphyromonadaceae	976|Bacteroidetes	K	Transcriptional regulator	asnC	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
SX3_k127_5654430_9	436308.Nmar_1113	4.977e-33	144.0	COG1236@1|root,arCOG00545@2157|Archaea,41SYB@651137|Thaumarchaeota	651137|Thaumarchaeota	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	-
SX3_k127_5654430_15	673860.AciM339_0276	7.812e-16	83.0	arCOG13537@1|root,arCOG13537@2157|Archaea,2Y1U2@28890|Euryarchaeota,3F2T4@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5654430_4	572478.Vdis_1970	3.478e-52	194.0	COG2086@1|root,arCOG00446@2157|Archaea,2XS2H@28889|Crenarchaeota	28889|Crenarchaeota	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
SX3_k127_5654430_3	643648.Slip_0876	8e-60	229.0	COG2025@1|root,COG2025@2|Bacteria,1V2AY@1239|Firmicutes,24FT1@186801|Clostridia,42KA5@68298|Syntrophomonadaceae	186801|Clostridia	C	Electron transfer flavoprotein domain	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
SX3_k127_5654430_17	673860.AciM339_0019	1.207e-15	92.0	COG0457@1|root,arCOG02493@1|root,arCOG02493@2157|Archaea,arCOG03038@2157|Archaea	2157|Archaea	KLT	Tetratricopeptide TPR_2 repeat protein	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	HTH_24,PQQ_2,PQQ_3,TPR_12,TPR_16,TPR_2,TPR_8
SX3_k127_5654430_7	1293054.HSACCH_01727	9.009e-36	153.0	2DFXS@1|root,2ZTMH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2330,Kunitz_BPTI
SX3_k127_5654430_8	589924.Ferp_1791	1.056e-34	151.0	arCOG13408@1|root,arCOG13408@2157|Archaea,2Y3GK@28890|Euryarchaeota,24702@183980|Archaeoglobi	183980|Archaeoglobi	S	Uncharacterized protein conserved in bacteria (DUF2330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2330
SX3_k127_5654430_5	449447.MAE_01800	4.232e-50	191.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria	1117|Cyanobacteria	O	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2
SX3_k127_5654430_18	858215.Thexy_0590	3.073e-15	85.0	COG2608@1|root,COG2608@2|Bacteria,1VERB@1239|Firmicutes,24U5J@186801|Clostridia,42H68@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Heavy metal transport detoxification protein	-	-	-	ko:K07213	ko04978,map04978	-	-	-	ko00000,ko00001	-	-	-	HMA
SX3_k127_5654430_10	1163408.UU9_12233	9.865e-30	138.0	COG2152@1|root,COG2152@2|Bacteria	2|Bacteria	G	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_130,Glyco_hydro_32N,Glyco_hydro_43
SX3_k127_5654430_16	525904.Tter_2775	9.057e-16	92.0	COG3420@1|root,COG3420@2|Bacteria,2NRSC@2323|unclassified Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	-	ko:K12287	-	-	-	-	ko00000,ko02044	-	-	-	Beta_helix,DUF3747,Laminin_G_3,NosD,PQQ_3
SX3_k127_5654430_0	273116.14324803	2.037e-139	454.0	COG1503@1|root,arCOG01742@2157|Archaea,2XSV5@28890|Euryarchaeota,241JX@183967|Thermoplasmata	183967|Thermoplasmata	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
SX3_k127_5654430_11	1233950.IW22_09585	4.276e-23	106.0	COG0399@1|root,COG0399@2|Bacteria,4PKRF@976|Bacteroidetes,1I2SV@117743|Flavobacteriia,3ZS3U@59732|Chryseobacterium	976|Bacteroidetes	J	S23 ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
SX3_k127_5654430_19	5671.XP_001468928.1	3.298e-05	57.0	COG1287@1|root,KOG2292@2759|Eukaryota,3XU9C@5653|Kinetoplastida	5653|Kinetoplastida	I	oligosaccharyl	-	-	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	STT3
SX3_k127_5654430_13	1121015.N789_02185	1.181e-20	97.0	COG1695@1|root,COG1695@2|Bacteria,1NJSY@1224|Proteobacteria,1SG6R@1236|Gammaproteobacteria,1X6UG@135614|Xanthomonadales	135614|Xanthomonadales	K	PadR family transcriptional regulator	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
SX3_k127_5654430_14	693661.Arcve_1837	1.419e-20	106.0	COG1287@1|root,arCOG02044@2157|Archaea,2Y4YN@28890|Euryarchaeota	28890|Euryarchaeota	S	oligosaccharyl transferase STT3 subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5654430_2	1191523.MROS_1240	3.464e-72	267.0	COG3104@1|root,COG3104@2|Bacteria	2|Bacteria	E	oligopeptide transport	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	MFS_1,PTR2
SX3_k127_5654430_1	1191523.MROS_1240	2.243e-72	269.0	COG3104@1|root,COG3104@2|Bacteria	2|Bacteria	E	oligopeptide transport	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	MFS_1,PTR2
SX3_k127_5654430_6	1379698.RBG1_1C00001G0936	3.047e-40	158.0	COG1335@1|root,COG1335@2|Bacteria,2NRGH@2323|unclassified Bacteria	2|Bacteria	Q	Isochorismatase family	-	-	3.5.1.110	ko:K09020	ko00240,ko01100,map00240,map01100	-	R09947,R09980	RC02737,RC02738	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
SX3_k127_5654430_12	742722.HMPREF9463_01629	2.239e-22	111.0	COG0492@1|root,COG0492@2|Bacteria,2GKD2@201174|Actinobacteria,4CVBT@84998|Coriobacteriia	84998|Coriobacteriia	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
SX3_k127_5683833_5	1304284.L21TH_1148	7.633e-15	81.0	2E6A2@1|root,330XY@2|Bacteria,1VISZ@1239|Firmicutes,24QK3@186801|Clostridia,36UF4@31979|Clostridiaceae	186801|Clostridia	S	Coenzyme PQQ synthesis protein D (PqqD)	-	-	-	-	-	-	-	-	-	-	-	-	PqqD
SX3_k127_5683833_0	342949.PNA2_0972	1.936e-115	398.0	COG1297@1|root,arCOG04807@2157|Archaea,2XVCD@28890|Euryarchaeota,243GY@183968|Thermococci	183968|Thermococci	S	OPT oligopeptide transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	OPT
SX3_k127_5683833_7	1464048.JNZS01000017_gene3583	1.722e-06	61.0	COG1572@1|root,COG1572@2|Bacteria,2H1Z9@201174|Actinobacteria,4DBYK@85008|Micromonosporales	201174|Actinobacteria	S	CARDB	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CARDB,F5_F8_type_C,Pectate_lyase_3
SX3_k127_5683833_3	1304885.AUEY01000152_gene187	3.637e-65	229.0	COG1853@1|root,COG1853@2|Bacteria,1RBSR@1224|Proteobacteria,42R0G@68525|delta/epsilon subdivisions,2WMYE@28221|Deltaproteobacteria,2MJGX@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
SX3_k127_5683833_4	158500.BV97_05460	1.072e-38	159.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,2TRSZ@28211|Alphaproteobacteria,2K046@204457|Sphingomonadales	204457|Sphingomonadales	L	DNA ligase	ligD	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
SX3_k127_5683833_2	667014.Thein_0953	7.751e-69	240.0	COG0177@1|root,COG0177@2|Bacteria,2GH3R@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
SX3_k127_5683833_6	102129.Lepto7375DRAFT_0842	1.759e-07	65.0	COG1572@1|root,COG3209@1|root,COG1572@2|Bacteria,COG3209@2|Bacteria,1G4UG@1117|Cyanobacteria,1HH6U@1150|Oscillatoriales	1117|Cyanobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,RHS_repeat
SX3_k127_5683833_1	572546.Arcpr_1724	9.672e-86	306.0	COG1032@1|root,arCOG01357@2157|Archaea,2XUCZ@28890|Euryarchaeota,246Y8@183980|Archaeoglobi	183980|Archaeoglobi	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
SX3_k127_5719020_8	1089545.KB913037_gene4310	0.0005014	53.0	COG1361@1|root,COG1361@2|Bacteria,2I8F1@201174|Actinobacteria,4DZF8@85010|Pseudonocardiales	201174|Actinobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
SX3_k127_5719020_6	1123400.KB904758_gene2277	5.453e-31	129.0	COG1100@1|root,COG1100@2|Bacteria,1RIAW@1224|Proteobacteria,1S6H6@1236|Gammaproteobacteria,462KK@72273|Thiotrichales	72273|Thiotrichales	S	Ras of Complex, Roc, domain of DAPkinase	-	-	-	-	-	-	-	-	-	-	-	-	Ras
SX3_k127_5719020_3	761193.Runsl_5265	1.822e-63	229.0	COG2135@1|root,COG2135@2|Bacteria,4NI3T@976|Bacteroidetes,47XPZ@768503|Cytophagia	976|Bacteroidetes	S	Belongs to the SOS response-associated peptidase family	yoqW	-	-	-	-	-	-	-	-	-	-	-	SRAP
SX3_k127_5719020_2	1408473.JHXO01000005_gene1750	5.396e-78	271.0	COG0384@1|root,COG0384@2|Bacteria,4NEWM@976|Bacteroidetes,2FSSJ@200643|Bacteroidia	976|Bacteroidetes	S	Phenazine biosynthesis-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
SX3_k127_5719020_0	1041930.Mtc_1212	2.222e-243	791.0	COG0046@1|root,arCOG00641@2157|Archaea,2XU49@28890|Euryarchaeota,2N93B@224756|Methanomicrobia	224756|Methanomicrobia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0536	AIRS,AIRS_C
SX3_k127_5719020_4	593750.Metfor_2813	2.416e-54	200.0	COG0047@1|root,arCOG00102@2157|Archaea,2XTPA@28890|Euryarchaeota	28890|Euryarchaeota	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2755	GATase_5
SX3_k127_5719020_7	316274.Haur_1599	1.013e-23	105.0	COG2345@1|root,COG2345@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24,HTH_34
SX3_k127_5719020_5	1484460.JSWG01000015_gene1146	7.639e-39	157.0	COG0457@1|root,COG2356@1|root,COG0457@2|Bacteria,COG2356@2|Bacteria,4NH2F@976|Bacteroidetes,1HZ6Z@117743|Flavobacteriia	976|Bacteroidetes	L	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
SX3_k127_5744299_0	673860.AciM339_1019	1.23e-196	623.0	COG1690@1|root,arCOG04246@2157|Archaea,2XTIC@28890|Euryarchaeota,3F2GK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	tRNA-splicing ligase RtcB	rtcB	GO:0000166,GO:0000394,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003972,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0017076,GO:0019001,GO:0019002,GO:0030145,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901363	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Intein_splicing,LAGLIDADG_3,RtcB
SX3_k127_5744299_3	436308.Nmar_0889	5.51e-05	49.0	arCOG10559@1|root,arCOG10559@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5744299_2	999541.bgla_2g19680	4.114e-06	60.0	COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,2VHRU@28216|Betaproteobacteria,1JZUU@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	amino acid adenylation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,Methyltransf_12,PP-binding,Thioesterase
SX3_k127_5744299_1	649638.Trad_0824	4.162e-09	70.0	COG1470@1|root,COG1470@2|Bacteria,1WIYF@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM NPCBM-associated, NEW3 domain of alpha-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	NPCBM_assoc
SX3_k127_5748491_6	572477.Alvin_1750	7.772e-31	140.0	COG0642@1|root,COG3437@1|root,COG5000@1|root,COG2205@2|Bacteria,COG3437@2|Bacteria,COG5000@2|Bacteria,1NRP8@1224|Proteobacteria,1T4M1@1236|Gammaproteobacteria,1WYGE@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,Response_reg,dCache_1
SX3_k127_5748491_5	313624.NSP_21450	2.269e-31	144.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G135@1117|Cyanobacteria,1HK1F@1161|Nostocales	1117|Cyanobacteria	S	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12,TPR_7,TPR_8
SX3_k127_5748491_8	357808.RoseRS_1308	7.257e-23	116.0	COG0642@1|root,COG3850@1|root,COG2205@2|Bacteria,COG3850@2|Bacteria,2G7J9@200795|Chloroflexi,37522@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase HAMP region domain protein	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,dCache_1
SX3_k127_5748491_1	401053.AciPR4_1793	2.501e-68	237.0	COG1945@1|root,COG1945@2|Bacteria,3Y3KR@57723|Acidobacteria,2JIBD@204432|Acidobacteriia	204432|Acidobacteriia	S	Pyruvoyl-dependent arginine decarboxylase (PvlArgDC)	-	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
SX3_k127_5748491_7	1236689.MMALV_00610	9.453e-27	124.0	COG1936@1|root,arCOG01038@2157|Archaea,2XX2A@28890|Euryarchaeota,3F2TT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates	adk2	-	2.7.4.3	ko:K18532	ko00230,ko01100,ko01110,ko01130,ko03008,map00230,map01100,map01110,map01130,map03008	M00049	R00127,R01547	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	AAA_18
SX3_k127_5748491_4	673860.AciM339_0002	2.114e-38	156.0	COG0681@1|root,arCOG01739@2157|Archaea,2Y6XH@28890|Euryarchaeota,3F2QN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	U	Signal peptidase	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	-
SX3_k127_5748491_3	1236689.MMALV_00620	1.029e-53	200.0	COG0558@1|root,arCOG00670@2157|Archaea,2XWJ0@28890|Euryarchaeota,3F2ME@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.39,2.7.8.5	ko:K00995,ko:K17884	ko00564,ko01100,map00564,map01100	-	R01801,R10464	RC00002,RC00017,RC00078,RC02795	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A1250	CDP-OH_P_transf
SX3_k127_5748491_9	382464.ABSI01000011_gene2473	1.098e-06	61.0	COG0028@1|root,COG1404@1|root,COG2885@1|root,COG3210@1|root,COG3291@1|root,COG3391@1|root,COG3507@1|root,COG4733@1|root,COG4935@1|root,COG5295@1|root,COG0028@2|Bacteria,COG1404@2|Bacteria,COG2885@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,COG3507@2|Bacteria,COG4733@2|Bacteria,COG4935@2|Bacteria,COG5295@2|Bacteria,46W6Z@74201|Verrucomicrobia	2|Bacteria	GMOU	Fibronectin type 3 domain	-	-	3.2.1.4,3.4.21.96,4.1.3.1,4.2.2.3	ko:K01179,ko:K01361,ko:K01637,ko:K01729,ko:K09942,ko:K20276	ko00051,ko00500,ko00630,ko01100,ko01110,ko01120,ko01200,ko02024,map00051,map00500,map00630,map01100,map01110,map01120,map01200,map02024	M00012	R00479,R03706,R06200,R11307,R11308	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	GH5,GH9	-	fn3
SX3_k127_5748491_2	573063.Metin_0388	4.971e-59	217.0	COG3294@1|root,arCOG04230@2157|Archaea,2XURZ@28890|Euryarchaeota	28890|Euryarchaeota	S	Phosphohydrolase	-	-	-	ko:K09163	-	-	-	-	ko00000	-	-	-	HD
SX3_k127_5748491_0	673860.AciM339_1421	6.865e-107	362.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,3F2ID@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	helicase superfamily c-terminal domain	hef	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,HHH_5,Helicase_C,ResIII
SX3_k127_5748590_0	439481.Aboo_1101	1.623e-136	445.0	COG3635@1|root,arCOG01696@2157|Archaea,2XTE8@28890|Euryarchaeota,3F2ZT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	apgM	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
SX3_k127_5748590_1	263820.PTO0280	1.825e-30	130.0	COG1836@1|root,arCOG02245@2157|Archaea,2XTBR@28890|Euryarchaeota,241UU@183967|Thermoplasmata	183967|Thermoplasmata	S	Integral membrane protein DUF92	-	-	-	-	-	-	-	-	-	-	-	-	DUF92
SX3_k127_5748590_2	1236689.MMALV_00410	6.621e-28	115.0	COG1698@1|root,arCOG04308@2157|Archaea,2XZVX@28890|Euryarchaeota,3F2TA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Uncharacterised protein family (UPF0147)	-	-	-	ko:K09721	-	-	-	-	ko00000	-	-	-	UPF0147
SX3_k127_5761784_13	553184.ATORI0001_0415	4.284e-06	53.0	COG1198@1|root,COG1198@2|Bacteria,2IH4H@201174|Actinobacteria,4CVKN@84998|Coriobacteriia	84998|Coriobacteriia	L	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	DZR
SX3_k127_5761784_9	351160.RCIX2735	8.232e-18	87.0	COG2002@1|root,arCOG00820@2157|Archaea	2157|Archaea	K	Transcriptional regulator, AbrB family	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
SX3_k127_5761784_7	673860.AciM339_0019	7.584e-22	114.0	COG0457@1|root,arCOG02493@1|root,arCOG02493@2157|Archaea,arCOG03038@2157|Archaea	2157|Archaea	KLT	Tetratricopeptide TPR_2 repeat protein	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	HTH_24,PQQ_2,PQQ_3,TPR_12,TPR_16,TPR_2,TPR_8
SX3_k127_5761784_3	1173023.KE650771_gene598	4.248e-56	227.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria,1JK6S@1189|Stigonemataceae	1117|Cyanobacteria	L	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_8
SX3_k127_5761784_12	523850.TON_0811	3.538e-06	57.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,2440W@183968|Thermococci	28890|Euryarchaeota	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24,HTH_5
SX3_k127_5761784_11	1051632.TPY_2981	9.379e-09	66.0	COG1476@1|root,COG1476@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3,HTH_31
SX3_k127_5761784_2	673860.AciM339_0495	2.196e-77	271.0	COG0467@1|root,arCOG01171@2157|Archaea,2XYM8@28890|Euryarchaeota,3F38P@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	Pfam:KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
SX3_k127_5761784_10	1232410.KI421424_gene1603	9.286e-11	74.0	COG0457@1|root,COG0457@2|Bacteria,1MUZK@1224|Proteobacteria,42WF6@68525|delta/epsilon subdivisions,2WS8U@28221|Deltaproteobacteria,43U1T@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_10,TPR_16,TPR_2,TPR_8
SX3_k127_5761784_6	439481.Aboo_1190	8.328e-28	123.0	COG3815@1|root,arCOG03949@2157|Archaea,2Y6YC@28890|Euryarchaeota,3F307@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Predicted membrane protein (DUF2085)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2085
SX3_k127_5761784_14	517418.Ctha_0987	2.095e-05	57.0	COG4206@1|root,COG4206@2|Bacteria	2|Bacteria	H	cobalamin-transporting ATPase activity	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
SX3_k127_5761784_15	1227272.HMPREF1556_00269	0.0007031	52.0	COG4773@1|root,COG4773@2|Bacteria,4NF92@976|Bacteroidetes,2FQRT@200643|Bacteroidia,22YG1@171551|Porphyromonadaceae	976|Bacteroidetes	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
SX3_k127_5761784_4	1236689.MMALV_01480	1.931e-51	190.0	COG1339@1|root,arCOG01904@2157|Archaea,2XTFW@28890|Euryarchaeota,3F2NZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN)	ribK	-	2.7.1.161	ko:K07732	ko00740,ko01100,map00740,map01100	-	R08574	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CTP-dep_RFKase,HTH_20,HTH_24,HTH_Crp_2
SX3_k127_5761784_5	552811.Dehly_1384	1.877e-38	154.0	COG1280@1|root,COG1280@2|Bacteria,2GBTY@200795|Chloroflexi,34CQW@301297|Dehalococcoidia	301297|Dehalococcoidia	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
SX3_k127_5761784_1	439481.Aboo_0093	5.033e-82	284.0	COG1084@1|root,arCOG00352@2157|Archaea,2XU5R@28890|Euryarchaeota,3F2J9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Nucleolar GTP-binding protein 1 (NOG1)	gbp4	-	-	ko:K06943	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	MMR_HSR1,NOG1
SX3_k127_5761784_8	335543.Sfum_0267	7.532e-19	89.0	COG2002@1|root,COG2002@2|Bacteria	2|Bacteria	K	toxin-antitoxin pair type II binding	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
SX3_k127_5761784_0	335543.Sfum_0266	1.581e-89	304.0	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,42PQM@68525|delta/epsilon subdivisions,2WJIF@28221|Deltaproteobacteria,2MRCK@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	HTH_20,Methyltransf_31
SX3_k127_5788318_2	1499967.BAYZ01000147_gene697	1.944e-62	219.0	COG1839@1|root,COG1839@2|Bacteria,2NPAQ@2323|unclassified Bacteria	2|Bacteria	S	Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
SX3_k127_5788318_1	1128421.JAGA01000001_gene2383	2.41e-79	277.0	COG0624@1|root,COG0624@2|Bacteria,2NQBR@2323|unclassified Bacteria	2|Bacteria	E	Peptidase family M20/M25/M40	lysK	-	3.5.1.16	ko:K01438,ko:K05831	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00028,M00031,M00763,M00845	R00669,R09107,R09779,R10933	RC00064,RC00090,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	Peptidase_M20
SX3_k127_5788318_0	316274.Haur_3309	4.285e-124	408.0	COG4992@1|root,COG4992@2|Bacteria,2G5SG@200795|Chloroflexi,375D1@32061|Chloroflexia	32061|Chloroflexia	E	Catalyzes the transfer of the amino group of L-glutamate to LysW -aminoadipate 6-semialdehyde, generating LysW -gamma-L- lysine	lysJ	-	-	ko:K05830	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00031,M00763	R09778,R10932	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SX3_k127_5788318_3	745776.DGo_CA1379	9.571e-61	215.0	COG0548@1|root,COG0548@2|Bacteria,1WIHT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Belongs to the acetylglutamate kinase family. LysZ subfamily	lysZ	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	ko:K05828	ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230	M00031,M00763	R09776,R10930	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
SX3_k127_5857318_0	697282.Mettu_2340	7.488e-55	216.0	COG3210@1|root,COG3420@1|root,COG3210@2|Bacteria,COG3420@2|Bacteria,1MXIP@1224|Proteobacteria,1RZM6@1236|Gammaproteobacteria,1XE6V@135618|Methylococcales	135618|Methylococcales	U	TIGRFAM Filamentous haemagglutinin	-	-	-	-	-	-	-	-	-	-	-	-	DUF3739,Haemagg_act
SX3_k127_5857318_1	1121405.dsmv_0629	2.486e-19	92.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2MIMJ@213118|Desulfobacterales	28221|Deltaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SX3_k127_5902034_0	673860.AciM339_0648	6.149e-218	688.0	COG1245@1|root,arCOG00187@2157|Archaea,2XSZE@28890|Euryarchaeota,3F2G2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	metal-binding domain in RNase L inhibitor, RLI	rli	GO:0000166,GO:0003674,GO:0005488,GO:0005506,GO:0005524,GO:0006412,GO:0006413,GO:0006415,GO:0006518,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0017076,GO:0019538,GO:0022411,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032984,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0046872,GO:0046914,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,RLI
SX3_k127_5902034_1	439481.Aboo_0814	1.578e-199	642.0	COG1793@1|root,arCOG01347@2157|Archaea,2XTCK@28890|Euryarchaeota,3F2GX@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
SX3_k127_5916476_5	272562.CA_C0244	6.053e-07	55.0	COG4591@1|root,COG4591@2|Bacteria,1TQ8J@1239|Firmicutes,24BJ2@186801|Clostridia,36ETG@31979|Clostridiaceae	186801|Clostridia	M	ABC-type transport system, involved in lipoprotein release, permease component	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
SX3_k127_5916476_0	1031288.AXAA01000009_gene734	8.871e-68	237.0	COG5012@1|root,COG5012@2|Bacteria,1V5EH@1239|Firmicutes,24HIB@186801|Clostridia,36J2Q@31979|Clostridiaceae	186801|Clostridia	S	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
SX3_k127_5916476_1	1236689.MMALV_00630	6.505e-66	250.0	COG2219@1|root,arCOG03013@2157|Archaea,2XTDT@28890|Euryarchaeota,3F2P0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priL	-	-	ko:K18882	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_lrg
SX3_k127_5916476_2	439481.Aboo_1134	1.183e-29	130.0	COG1916@1|root,arCOG02142@2157|Archaea,2Y6XP@28890|Euryarchaeota,3F2SA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	TraB family	-	-	-	-	-	-	-	-	-	-	-	-	TraB
SX3_k127_5916476_3	529818.AMSG_00600T0	3.198e-11	77.0	KOG1218@1|root,KOG1225@1|root,KOG3594@1|root,KOG3597@1|root,KOG1218@2759|Eukaryota,KOG1225@2759|Eukaryota,KOG3597@2759|Eukaryota,KOG4289@2759|Eukaryota	2759|Eukaryota	O	homophilic cell adhesion via plasma membrane adhesion molecules	CSPG4	GO:0000187,GO:0000323,GO:0001932,GO:0001934,GO:0003674,GO:0005488,GO:0005515,GO:0005518,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005773,GO:0005775,GO:0005794,GO:0005796,GO:0005886,GO:0005887,GO:0005912,GO:0005924,GO:0005927,GO:0006022,GO:0006023,GO:0006024,GO:0006026,GO:0006027,GO:0006029,GO:0006082,GO:0006790,GO:0006807,GO:0006928,GO:0006950,GO:0006952,GO:0006954,GO:0006996,GO:0007010,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007169,GO:0007186,GO:0007275,GO:0007399,GO:0007517,GO:0008150,GO:0008152,GO:0008283,GO:0008347,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009653,GO:0009893,GO:0009966,GO:0009967,GO:0009987,GO:0010035,GO:0010038,GO:0010226,GO:0010562,GO:0010604,GO:0010646,GO:0010647,GO:0010721,GO:0010927,GO:0010975,GO:0010977,GO:0012505,GO:0016020,GO:0016021,GO:0016043,GO:0016053,GO:0016203,GO:0016322,GO:0016477,GO:0017144,GO:0019220,GO:0019222,GO:0019538,GO:0019752,GO:0019899,GO:0019900,GO:0019901,GO:0021700,GO:0022008,GO:0022607,GO:0023051,GO:0023052,GO:0023056,GO:0030016,GO:0030017,GO:0030018,GO:0030029,GO:0030036,GO:0030054,GO:0030055,GO:0030154,GO:0030166,GO:0030182,GO:0030203,GO:0030204,GO:0030205,GO:0030206,GO:0030207,GO:0030208,GO:0030239,GO:0031032,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031344,GO:0031345,GO:0031346,GO:0031399,GO:0031401,GO:0031674,GO:0031974,GO:0032147,GO:0032268,GO:0032270,GO:0032501,GO:0032502,GO:0032787,GO:0032989,GO:0033674,GO:0034645,GO:0035556,GO:0040011,GO:0042063,GO:0042221,GO:0042325,GO:0042327,GO:0042551,GO:0042692,GO:0042995,GO:0043034,GO:0043085,GO:0043170,GO:0043202,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043292,GO:0043405,GO:0043406,GO:0043408,GO:0043410,GO:0043436,GO:0043549,GO:0044085,GO:0044087,GO:0044089,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044272,GO:0044273,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044437,GO:0044444,GO:0044446,GO:0044449,GO:0044459,GO:0044464,GO:0044877,GO:0045214,GO:0045595,GO:0045596,GO:0045664,GO:0045665,GO:0045859,GO:0045860,GO:0045937,GO:0046394,GO:0048468,GO:0048469,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048646,GO:0048666,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0048870,GO:0050650,GO:0050651,GO:0050654,GO:0050655,GO:0050730,GO:0050731,GO:0050767,GO:0050768,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051093,GO:0051128,GO:0051129,GO:0051130,GO:0051146,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051286,GO:0051338,GO:0051347,GO:0051489,GO:0051491,GO:0051674,GO:0051716,GO:0051960,GO:0051961,GO:0055001,GO:0055002,GO:0060255,GO:0060284,GO:0060491,GO:0060538,GO:0061061,GO:0065007,GO:0065009,GO:0070013,GO:0070161,GO:0070925,GO:0071695,GO:0071704,GO:0071840,GO:0071900,GO:0071902,GO:0071944,GO:0072330,GO:0080090,GO:0097435,GO:0099080,GO:0099081,GO:0099512,GO:0120032,GO:0120034,GO:0120035,GO:1901135,GO:1901136,GO:1901137,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1902531,GO:1902533,GO:1903510,GO:2000026	-	ko:K02599,ko:K08115,ko:K16507,ko:K16669,ko:K19013	ko01522,ko04320,ko04330,ko04391,ko04392,ko04658,ko04919,ko05020,ko05165,ko05200,ko05206,ko05224,map01522,map04320,map04330,map04391,map04392,map04658,map04919,map05020,map05165,map05200,map05206,map05224	M00682	-	-	ko00000,ko00001,ko00002,ko00535,ko00536,ko04516	-	-	-	Cadherin_3,EB,Laminin_G_2
SX3_k127_5916476_4	386456.JQKN01000009_gene1129	2.016e-09	71.0	COG3291@1|root,arCOG02555@1|root,arCOG07611@1|root,arCOG02546@2157|Archaea,arCOG02555@2157|Archaea,arCOG07611@2157|Archaea	2157|Archaea	E	Conserved repeat domain	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Big_5,CARDB,CHB_HEX_C_1,CarboxypepD_reg,Cellulase,DUF11,PKD,PQQ_3,SBBP,VWA
SX3_k127_5921686_12	357276.EL88_03020	6.65e-06	59.0	COG0526@1|root,COG0526@2|Bacteria,4NT67@976|Bacteroidetes,2FQHA@200643|Bacteroidia,4AW6H@815|Bacteroidaceae	976|Bacteroidetes	O	Thioredoxin	resA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DUF4369,Thioredoxin_8
SX3_k127_5921686_13	1008453.HMPREF9957_1822	8.787e-06	58.0	COG0785@1|root,COG0785@2|Bacteria,1TQH1@1239|Firmicutes,4H9UJ@91061|Bacilli,2TPEQ@28037|Streptococcus mitis	91061|Bacilli	O	Cytochrome C biogenesis protein transmembrane region	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
SX3_k127_5921686_2	1386089.N865_05350	5.468e-74	282.0	COG4733@1|root,COG4733@2|Bacteria,2I7XV@201174|Actinobacteria,4FK2V@85021|Intrasporangiaceae	201174|Actinobacteria	M	Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	fn3
SX3_k127_5921686_10	1203611.KB894541_gene1480	3.591e-09	71.0	2DXEA@1|root,344NC@2|Bacteria,4NWA2@976|Bacteroidetes,2FV6Z@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5921686_11	368407.Memar_0017	1.994e-07	57.0	arCOG03645@1|root,arCOG03645@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5921686_0	255470.cbdbA785	5.286e-140	462.0	COG1233@1|root,COG1233@2|Bacteria,2G5ZA@200795|Chloroflexi,34D93@301297|Dehalococcoidia	301297|Dehalococcoidia	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
SX3_k127_5921686_8	192952.MM_2605	1.59e-11	68.0	COG2026@1|root,arCOG01665@2157|Archaea	2157|Archaea	DJ	PFAM plasmid stabilization system	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
SX3_k127_5921686_14	1094980.Mpsy_1960	4.116e-05	48.0	arCOG10361@1|root,arCOG10361@2157|Archaea,2Y5Z6@28890|Euryarchaeota,2NBEF@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5921686_3	1449350.OCH239_12355	3.698e-58	216.0	2DWJF@1|root,340NC@2|Bacteria,1NYAU@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5921686_4	1210884.HG799465_gene12237	1.118e-41	158.0	COG0662@1|root,COG0662@2|Bacteria,2J42S@203682|Planctomycetes	203682|Planctomycetes	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SX3_k127_5921686_6	1499967.BAYZ01000105_gene3534	5.552e-26	111.0	2C914@1|root,32T2A@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5921686_9	476272.RUMHYD_03427	3.278e-11	70.0	COG0454@1|root,COG0456@2|Bacteria,1V4GU@1239|Firmicutes,24IME@186801|Clostridia,3Y03S@572511|Blautia	186801|Clostridia	K	Psort location Cytoplasmic, score 8.87	RimI	-	2.3.1.1	ko:K22477	ko00220,ko01210,ko01230,map00220,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10
SX3_k127_5921686_7	1288298.rosmuc_00647	2.621e-25	123.0	COG2911@1|root,COG2931@1|root,COG3188@1|root,COG3209@1|root,COG4932@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3188@2|Bacteria,COG3209@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,46P2B@74030|Roseovarius	28211|Alphaproteobacteria	MQ	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Cadherin_3,DUF4214,GDPD,He_PIG,HemolysinCabind,PA14,PPC,Peptidase_M10_C
SX3_k127_5921686_1	673860.AciM339_1381	5.812e-82	293.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTGJ@28890|Euryarchaeota,3F2KP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	rpa1	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	-
SX3_k127_5921686_5	351160.LRC265	2.699e-40	161.0	COG3390@1|root,arCOG02258@2157|Archaea,2XT3R@28890|Euryarchaeota,2N9P2@224756|Methanomicrobia	224756|Methanomicrobia	S	protein conserved in archaea	-	-	-	ko:K09746	-	-	-	-	ko00000	-	-	-	-
SX3_k127_595247_3	1219084.AP014508_gene682	1.019e-22	100.0	COG0281@1|root,COG0281@2|Bacteria,2GCGT@200918|Thermotogae	200918|Thermotogae	C	PFAM malic	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
SX3_k127_595247_8	471853.Bcav_0997	5.281e-08	67.0	COG3291@1|root,COG3391@1|root,COG3291@2|Bacteria,COG3391@2|Bacteria,2GN7G@201174|Actinobacteria	201174|Actinobacteria	P	PFAM PKD domain containing protein	wcoG	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PKD
SX3_k127_595247_9	509191.AEDB02000065_gene674	7.471e-06	60.0	COG1705@1|root,COG3291@1|root,COG4409@1|root,COG4733@1|root,COG1705@2|Bacteria,COG3291@2|Bacteria,COG4409@2|Bacteria,COG4733@2|Bacteria,1UKT9@1239|Firmicutes,25G34@186801|Clostridia,3WP43@541000|Ruminococcaceae	2|Bacteria	NU	PKD domain	wcoB	-	3.2.1.4	ko:K01179,ko:K02395	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000,ko02035	-	GH5,GH9	-	Beta_helix,PKD
SX3_k127_595247_4	767029.HMPREF9154_2993	1.309e-16	96.0	COG2319@1|root,COG2319@2|Bacteria,2GJN3@201174|Actinobacteria,4DW65@85009|Propionibacteriales	201174|Actinobacteria	S	WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	NACHT,NB-ARC,PD40,Pentapeptide,WD40
SX3_k127_595247_6	519442.Huta_2910	3.434e-14	87.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWHT@28890|Euryarchaeota,23V64@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	gntR	-	-	-	-	-	-	-	-	-	-	-	HTH_24,HTH_5,MarR_2
SX3_k127_595247_7	765912.Thimo_1752	2.031e-08	68.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,1RZ6G@1236|Gammaproteobacteria,1X1H2@135613|Chromatiales	135613|Chromatiales	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
SX3_k127_595247_2	797114.C475_09614	4.118e-27	129.0	COG1520@1|root,COG3291@1|root,arCOG03441@1|root,arCOG03991@1|root,arCOG02492@2157|Archaea,arCOG02508@2157|Archaea,arCOG02546@2157|Archaea,arCOG03441@2157|Archaea,arCOG03991@2157|Archaea,2XUY6@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Malectin,PKD,Pilin_N,SdrD_B
SX3_k127_595247_5	662479.C440_04353	8.909e-15	87.0	arCOG01314@1|root,arCOG01314@2157|Archaea,2XVNC@28890|Euryarchaeota,23TF3@183963|Halobacteria	183963|Halobacteria	L	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF4350
SX3_k127_595247_1	357808.RoseRS_3183	2.381e-35	150.0	COG1721@1|root,COG1721@2|Bacteria,2G7JJ@200795|Chloroflexi	200795|Chloroflexi	M	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
SX3_k127_595247_0	386456.JQKN01000002_gene2894	3.406e-139	464.0	COG1193@1|root,arCOG02895@2157|Archaea,2XT51@28890|Euryarchaeota,23NQB@183925|Methanobacteria	183925|Methanobacteria	L	Has ATPase and non-specific DNA-binding activities	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH_5,MutS_V
SX3_k127_5955675_1	1170562.Cal6303_1704	4.168e-31	126.0	COG4804@1|root,COG4804@2|Bacteria,1G1QU@1117|Cyanobacteria,1HM6D@1161|Nostocales	1117|Cyanobacteria	S	Protein of unknown function (DUF1016)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1016
SX3_k127_5955675_0	1408473.JHXO01000015_gene1906	6.278e-44	186.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	nanA	GO:0001573,GO:0003674,GO:0003824,GO:0004308,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006672,GO:0006687,GO:0006689,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0016020,GO:0016042,GO:0016052,GO:0016787,GO:0016798,GO:0016997,GO:0019377,GO:0030149,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044424,GO:0044464,GO:0046466,GO:0046479,GO:0046514,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1903509	3.2.1.18	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	-	R04018	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33	-	BNR_2,Gram_pos_anchor,Sialidase,YSIRK_signal
SX3_k127_5955675_3	349161.Dred_0966	4.253e-06	61.0	2B79F@1|root,320C5@2|Bacteria,1UV9B@1239|Firmicutes,25I7N@186801|Clostridia,266CF@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_5955675_2	717606.PaecuDRAFT_2136	5.227e-19	104.0	COG1520@1|root,COG3210@1|root,COG4412@1|root,COG5276@1|root,COG5492@1|root,COG1520@2|Bacteria,COG3210@2|Bacteria,COG4412@2|Bacteria,COG5276@2|Bacteria,COG5492@2|Bacteria,1TR9M@1239|Firmicutes,4HEPP@91061|Bacilli,26T62@186822|Paenibacillaceae	91061|Bacilli	U	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Cadherin-like,Cohesin,Invasin_D3,SLH
SX3_k127_6024328_5	1499683.CCFF01000016_gene936	2.574e-39	154.0	COG3404@1|root,COG3404@2|Bacteria,1V1X8@1239|Firmicutes,24JZM@186801|Clostridia,36JRA@31979|Clostridiaceae	186801|Clostridia	E	cyclohydrolase	fchA	-	-	-	-	-	-	-	-	-	-	-	FTCD_C
SX3_k127_6024328_11	45157.CMH001CT	5.842e-09	70.0	KOG3638@1|root,KOG3638@2759|Eukaryota	2759|Eukaryota	M	intein-mediated protein splicing	-	GO:0003002,GO:0003674,GO:0003824,GO:0004175,GO:0005102,GO:0005488,GO:0005496,GO:0005515,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0007154,GO:0007267,GO:0007275,GO:0007350,GO:0007365,GO:0007367,GO:0007389,GO:0008150,GO:0008152,GO:0008233,GO:0008289,GO:0009790,GO:0009880,GO:0009987,GO:0010467,GO:0015485,GO:0016020,GO:0016485,GO:0016540,GO:0016787,GO:0019538,GO:0023052,GO:0032501,GO:0032502,GO:0032934,GO:0035282,GO:0036094,GO:0043170,GO:0043178,GO:0044238,GO:0044464,GO:0048856,GO:0051604,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0140096,GO:1901564	-	ko:K06224,ko:K11990,ko:K16669	ko04340,ko04341,ko04391,ko04392,map04340,map04341,map04391,map04392	M00678	-	-	ko00000,ko00001,ko00002,ko00536,ko01002,ko04516	-	-	-	Ground-like,Hint,Kelch_4
SX3_k127_6024328_10	443254.Marpi_0767	7.096e-11	76.0	COG5276@1|root,COG5276@2|Bacteria,2GD6R@200918|Thermotogae	200918|Thermotogae	S	PFAM Fibronectin, type III domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_6024328_1	439481.Aboo_0751	9.772e-158	513.0	COG0433@1|root,arCOG00280@2157|Archaea,2XZQZ@28890|Euryarchaeota,3F34M@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
SX3_k127_6024328_9	1128427.KB904821_gene3125	2.705e-16	81.0	COG2886@1|root,COG2886@2|Bacteria,1GB0F@1117|Cyanobacteria	1117|Cyanobacteria	S	Uncharacterised protein family (UPF0175)	-	-	-	-	-	-	-	-	-	-	-	-	UPF0175
SX3_k127_6024328_7	246969.TAM4_1282	2.377e-24	108.0	COG2405@1|root,arCOG00717@2157|Archaea,2Y6UJ@28890|Euryarchaeota,24583@183968|Thermococci	183968|Thermococci	V	Domain of unknown function (DUF3368)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3368
SX3_k127_6024328_12	243232.MJ_0416	6.678e-05	57.0	arCOG01917@1|root,arCOG01917@2157|Archaea,2XWXW@28890|Euryarchaeota,23QUZ@183939|Methanococci	183939|Methanococci	S	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	DZR,zf-ribbon_3,zinc_ribbon_2
SX3_k127_6024328_4	1123508.JH636453_gene5802	6.743e-51	209.0	COG3210@1|root,COG3391@1|root,COG3827@1|root,COG4932@1|root,COG3210@2|Bacteria,COG3391@2|Bacteria,COG3827@2|Bacteria,COG4932@2|Bacteria,2IY8U@203682|Planctomycetes	203682|Planctomycetes	M	Integrin alpha (beta-propellor repeats).	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
SX3_k127_6024328_6	1183438.GKIL_3582	1.267e-36	163.0	COG2373@1|root,COG2373@2|Bacteria,1G1A1@1117|Cyanobacteria	1117|Cyanobacteria	S	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,CarboxypepD_reg,MG1,Thiol-ester_cl
SX3_k127_6024328_8	926550.CLDAP_28350	1.067e-17	97.0	COG3266@1|root,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,G5,Gln_amidase,Gram_pos_anchor,YSIRK_signal,YadA_stalk
SX3_k127_6024328_2	439481.Aboo_0070	4.032e-68	233.0	COG0048@1|root,arCOG04255@2157|Archaea,2XX4A@28890|Euryarchaeota,3F2K0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits	rps12	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
SX3_k127_6024328_3	693661.Arcve_1347	2.781e-57	209.0	COG0049@1|root,arCOG04254@2157|Archaea,2XTDC@28890|Euryarchaeota,245YE@183980|Archaeoglobi	183980|Archaeoglobi	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center	rps7	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
SX3_k127_6024328_0	263820.PTO0417	9.825e-278	869.0	COG0480@1|root,arCOG01559@2157|Archaea,2XUMQ@28890|Euryarchaeota,241J6@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
SX3_k127_6038712_9	1379698.RBG1_1C00001G0991	4.45e-06	56.0	COG2911@1|root,COG2931@1|root,COG4447@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG4447@2|Bacteria,2NR5X@2323|unclassified Bacteria	2|Bacteria	Q	FlgD Ig-like domain	-	-	3.2.1.136	ko:K15924	-	-	-	-	ko00000,ko01000	-	GH5	-	CBM_3,DUF1735,Laminin_G_3
SX3_k127_6038712_1	1236689.MMALV_05030	1.076e-71	258.0	COG1537@1|root,arCOG01741@2157|Archaea,2XTQ4@28890|Euryarchaeota,3F2P2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity	pelA	GO:0000956,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006402,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0019222,GO:0019439,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0034655,GO:0034660,GO:0034661,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0070651,GO:0070966,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1901361,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903008	-	ko:K06965	ko03015,map03015	-	-	-	ko00000,ko00001	-	-	-	eRF1_1,eRF1_2,eRF1_3
SX3_k127_6038712_6	673860.AciM339_0022	1.581e-15	88.0	COG1522@1|root,arCOG01580@2157|Archaea,arCOG01585@2157|Archaea,2Y6YT@28890|Euryarchaeota,3F2Y0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_6038712_8	47716.JOFH01000035_gene4118	2.46e-06	60.0	COG1572@1|root,COG2356@1|root,COG5434@1|root,COG1572@2|Bacteria,COG2356@2|Bacteria,COG5434@2|Bacteria,2GKCR@201174|Actinobacteria	201174|Actinobacteria	M	Coagulation factor 5 8 type domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ASH,Beta_helix,CARDB,DUF1573,F5_F8_type_C,Pectate_lyase_3
SX3_k127_6038712_2	439481.Aboo_0164	1.08e-70	249.0	COG1578@1|root,arCOG04410@2157|Archaea,2XWGU@28890|Euryarchaeota,3F2KN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function DUF89	-	-	-	ko:K09116	-	-	-	-	ko00000	-	-	-	DUF89
SX3_k127_6038712_0	673860.AciM339_1270	1.744e-87	313.0	COG1955@1|root,arCOG01809@2157|Archaea,2XTAX@28890|Euryarchaeota,3F2ZF@33867|unclassified Euryarchaeota	28890|Euryarchaeota	N	Type II secretion system	flaJ	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
SX3_k127_6038712_3	506534.Rhein_4007	4.036e-47	196.0	COG2982@1|root,COG3210@1|root,COG3637@1|root,COG4932@1|root,COG2982@2|Bacteria,COG3210@2|Bacteria,COG3637@2|Bacteria,COG4932@2|Bacteria,1QUXB@1224|Proteobacteria	1224|Proteobacteria	U	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,Cadherin_3,Calx-beta,DUF11,DUF4347,He_PIG,OmpA_membrane,PATR,VCBS
SX3_k127_6038712_4	1038862.KB893834_gene4816	1.112e-45	192.0	COG3210@1|root,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,2TTVB@28211|Alphaproteobacteria,3JS9Y@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	U	haemagglutination activity domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3739,Glug,Haemagg_act
SX3_k127_6038712_5	351160.RCIX240	2.869e-28	126.0	arCOG01190@1|root,arCOG01190@2157|Archaea,2XV67@28890|Euryarchaeota	28890|Euryarchaeota	T	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	RIO1
SX3_k127_6038712_7	368407.Memar_0091	2.052e-07	55.0	COG3398@1|root,arCOG02611@2157|Archaea	2157|Archaea	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
SX3_k127_6046263_9	1051632.TPY_1085	1.815e-53	197.0	COG0652@1|root,COG0652@2|Bacteria,1TRHW@1239|Firmicutes,247XN@186801|Clostridia,3WD67@538999|Clostridiales incertae sedis	186801|Clostridia	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
SX3_k127_6046263_42	523850.TON_0811	9.614e-10	68.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,2440W@183968|Thermococci	28890|Euryarchaeota	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24,HTH_5
SX3_k127_6046263_16	1094980.Mpsy_0644	9.06e-45	187.0	arCOG02542@1|root,arCOG10954@1|root,arCOG02542@2157|Archaea,arCOG10954@2157|Archaea,2XV12@28890|Euryarchaeota	28890|Euryarchaeota	U	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	-	-	-	-	-	-	-	-	-	-	-	-	Glug
SX3_k127_6046263_1	1236689.MMALV_14260	2.691e-107	361.0	COG0087@1|root,arCOG04070@2157|Archaea,2XT9B@28890|Euryarchaeota,3F2H1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl3	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
SX3_k127_6046263_6	439481.Aboo_1520	1.524e-69	244.0	COG0469@1|root,arCOG04071@2157|Archaea,2XTXX@28890|Euryarchaeota,3F2K6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Forms part of the polypeptide exit tunnel	rpl4	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02930	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
SX3_k127_6046263_38	673860.AciM339_1100	4.29e-19	98.0	COG0089@1|root,arCOG04072@2157|Archaea,2XYPG@28890|Euryarchaeota,3F2T9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome	rpl23	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
SX3_k127_6046263_7	673860.AciM339_1101	7.093e-65	236.0	COG0090@1|root,arCOG04067@2157|Archaea,2XTCS@28890|Euryarchaeota,3F2KT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Ribosomal Proteins L2, C-terminal domain	rpl2	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
SX3_k127_6046263_15	673860.AciM339_1102	6.32e-45	168.0	COG0185@1|root,arCOG04099@2157|Archaea,2XWI9@28890|Euryarchaeota,3F2NY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rps19p	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
SX3_k127_6046263_25	192952.MM_2129	6.293e-33	139.0	COG0091@1|root,arCOG04098@2157|Archaea,2XWGN@28890|Euryarchaeota,2N9UR@224756|Methanomicrobia	224756|Methanomicrobia	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rpl22	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
SX3_k127_6046263_4	1236689.MMALV_14200	5.51e-79	271.0	COG0092@1|root,arCOG04097@2157|Archaea,2XTHR@28890|Euryarchaeota,3F2JC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	ribosomal protein S3	rps3	GO:0000702,GO:0002181,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003735,GO:0003824,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006281,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008534,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
SX3_k127_6046263_39	439481.Aboo_1514	4.994e-16	79.0	COG0255@1|root,arCOG00785@2157|Archaea,2Y1DQ@28890|Euryarchaeota,3F2VT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Ribosomal L29 protein	rpl29	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
SX3_k127_6046263_20	1236689.MMALV_14180	1.664e-39	148.0	COG0023@1|root,arCOG04223@2157|Archaea,2XXW5@28890|Euryarchaeota,3F2TV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Translation initiation factor SUI1	tif1a	GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0002190,GO:0002192,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0110017,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
SX3_k127_6046263_41	634498.mru_0860	7.223e-12	70.0	COG1588@1|root,arCOG00784@2157|Archaea,2Y0EN@28890|Euryarchaeota,23PQP@183925|Methanobacteria	183925|Methanobacteria	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp1	-	3.1.26.5	ko:K03538	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	UPF0086
SX3_k127_6046263_22	673860.AciM339_1107	6.428e-35	145.0	COG0186@1|root,arCOG04096@2157|Archaea,2XYPE@28890|Euryarchaeota,3F2Q9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rps17	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
SX3_k127_6046263_13	273075.Ta1261	3.022e-50	181.0	COG0093@1|root,arCOG04095@2157|Archaea,2XWM6@28890|Euryarchaeota,241QD@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rpl14	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
SX3_k127_6046263_33	439481.Aboo_1510	1.69e-22	105.0	COG0198@1|root,arCOG04094@2157|Archaea,2XXV4@28890|Euryarchaeota,3F2SR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	ribosomal protein L24	rpl24	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,Ribosomal_L26
SX3_k127_6046263_5	439481.Aboo_1509	1.31e-69	243.0	COG1471@1|root,arCOG04093@2157|Archaea,2XT03@28890|Euryarchaeota,3F2KF@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Ribosomal family S4e	rps4e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02987	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	RS4NT,Ribosomal_S4e,S4
SX3_k127_6046263_8	1054217.TALC_01321	3.784e-58	219.0	COG0094@1|root,arCOG04092@2157|Archaea,2XTRN@28890|Euryarchaeota,241QF@183967|Thermoplasmata	183967|Thermoplasmata	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rpl5	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
SX3_k127_6046263_36	1236689.MMALV_14120	7.259e-20	89.0	COG0199@1|root,arCOG00782@2157|Archaea,2Y68V@28890|Euryarchaeota,3F2V3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	ribosomal protein S14	rps14	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
SX3_k127_6046263_10	1236689.MMALV_14110	2.019e-53	190.0	COG0096@1|root,arCOG04091@2157|Archaea,2XWMU@28890|Euryarchaeota,3F2NR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rps8	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
SX3_k127_6046263_11	439481.Aboo_1505	2.4e-52	190.0	COG0097@1|root,arCOG04090@2157|Archaea,2XTIS@28890|Euryarchaeota,3F2ND@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rpl6	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
SX3_k127_6046263_23	673860.AciM339_1115	5.126e-34	141.0	COG1717@1|root,arCOG00781@2157|Archaea,2XSZ4@28890|Euryarchaeota,3F2PV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eL32 family	rpl32e	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02912	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	HHH_5,Ribosomal_L32e
SX3_k127_6046263_24	694429.Pyrfu_1677	6.399e-34	139.0	COG2147@1|root,arCOG04089@2157|Archaea,2XQFM@28889|Crenarchaeota	28889|Crenarchaeota	J	binds to the 23S rRNA	rpl19e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02885	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19e
SX3_k127_6046263_14	673860.AciM339_1117	1.829e-48	184.0	COG0256@1|root,arCOG04088@2157|Archaea,2XTWT@28890|Euryarchaeota,3F2QM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rpl18	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18_c,Ribosomal_L5e
SX3_k127_6046263_3	1236689.MMALV_14060	6.052e-83	287.0	COG0098@1|root,arCOG04087@2157|Archaea,2XUQU@28890|Euryarchaeota,3F2HF@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	With S4 and S12 plays an important role in translational accuracy	rps5	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
SX3_k127_6046263_17	523850.TON_0087	1.14e-44	168.0	COG1841@1|root,arCOG04086@2157|Archaea,2XWGP@28890|Euryarchaeota,243IZ@183968|Thermococci	183968|Thermococci	J	Ribosomal protein L30	rpl30	GO:0000463,GO:0000470,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
SX3_k127_6046263_29	1236689.MMALV_14040	1.071e-29	129.0	COG0200@1|root,arCOG00779@2157|Archaea,2XWM3@28890|Euryarchaeota,3F2U3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	ribosomal protein L15	rpl15	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
SX3_k127_6046263_0	439481.Aboo_1498	5.854e-198	629.0	COG5253@1|root,arCOG04169@2157|Archaea,2XT9A@28890|Euryarchaeota,3F2F6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	Plug_translocon,SecY
SX3_k127_6046263_31	673860.AciM339_1123	5.649e-24	111.0	COG1422@1|root,arCOG02673@2157|Archaea,2XZDK@28890|Euryarchaeota,3F2U5@33867|unclassified Euryarchaeota	28890|Euryarchaeota	U	Integral membrane protein DUF106	-	-	-	-	-	-	-	-	-	-	-	-	DUF106
SX3_k127_6046263_19	647113.Metok_0685	5.846e-41	169.0	COG1102@1|root,arCOG01037@2157|Archaea,2XWPB@28890|Euryarchaeota,23QTJ@183939|Methanococci	183939|Methanococci	F	Belongs to the cytidylate kinase family. Type 2 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
SX3_k127_6046263_2	192952.MM_2154	3.665e-105	360.0	COG0130@1|root,arCOG00987@2157|Archaea,2XTUE@28890|Euryarchaeota,2N99I@224756|Methanomicrobia	224756|Methanomicrobia	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177,ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03016,ko03032	-	-	-	DKCLD,PUA,TruB_C_2,TruB_N
SX3_k127_6046263_35	186497.PF0420	3.719e-22	113.0	COG1305@1|root,arCOG02486@2157|Archaea,2Y7MU@28890|Euryarchaeota,243KB@183968|Thermococci	183968|Thermococci	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
SX3_k127_6046263_28	548477.HMPREF0294_1175	7.632e-30	139.0	COG1800@1|root,COG1800@2|Bacteria	2|Bacteria	O	translation initiation factor activity	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,Rib,TSP_3
SX3_k127_6046263_32	485914.Hmuk_0096	9.754e-24	117.0	arCOG01314@1|root,arCOG01314@2157|Archaea,2XVNC@28890|Euryarchaeota,23TF3@183963|Halobacteria	183963|Halobacteria	L	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF4350
SX3_k127_6046263_26	926569.ANT_09540	4.239e-32	145.0	COG1361@1|root,COG1721@1|root,COG1361@2|Bacteria,COG1721@2|Bacteria,2G7JJ@200795|Chloroflexi	200795|Chloroflexi	M	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
SX3_k127_6046263_27	1123400.KB904758_gene2277	1.419e-31	131.0	COG1100@1|root,COG1100@2|Bacteria,1RIAW@1224|Proteobacteria,1S6H6@1236|Gammaproteobacteria,462KK@72273|Thiotrichales	72273|Thiotrichales	S	Ras of Complex, Roc, domain of DAPkinase	-	-	-	-	-	-	-	-	-	-	-	-	Ras
SX3_k127_6046263_34	1343739.PAP_01925	2.292e-22	104.0	COG1644@1|root,arCOG04244@2157|Archaea,2Y03I@28890|Euryarchaeota,244I0@183968|Thermococci	183968|Thermococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoN	GO:0000428,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008270,GO:0030880,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03058	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_N
SX3_k127_6046263_18	572546.Arcpr_0131	2.37e-41	161.0	COG0088@1|root,arCOG04243@2157|Archaea,2XWK0@28890|Euryarchaeota,2471N@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the universal ribosomal protein uS9 family	rps9	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
SX3_k127_6046263_21	351160.LRC406	3.983e-39	150.0	COG0102@1|root,arCOG04242@2157|Archaea,2XWN6@28890|Euryarchaeota,2N9Q5@224756|Methanomicrobia	224756|Methanomicrobia	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rpl13	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
SX3_k127_6046263_37	1198449.ACAM_1095	7.996e-20	94.0	COG1727@1|root,arCOG00780@2157|Archaea,2XQV1@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL18 family	rpl18e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02883	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18,Ribosomal_L27A
SX3_k127_6046263_12	1298865.H978DRAFT_1289	1.769e-51	191.0	COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,1RN5M@1236|Gammaproteobacteria,464RW@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	ftsJ	GO:0000027,GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008650,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022607,GO:0022613,GO:0022618,GO:0031167,GO:0032259,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043414,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
SX3_k127_6046263_30	910964.GEAM_2371	1.678e-25	124.0	COG2911@1|root,COG4932@1|root,COG2911@2|Bacteria,COG4932@2|Bacteria,1P8N9@1224|Proteobacteria,1T1IH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	PFAM FecR protein	yeeJ	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Big_3_3
SX3_k127_6046263_40	552811.Dehly_0938	8.699e-14	72.0	COG0322@1|root,COG0322@2|Bacteria,2G651@200795|Chloroflexi,34CKY@301297|Dehalococcoidia	301297|Dehalococcoidia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,UVR,UvrC_HhH_N
SX3_k127_6046266_0	1242864.D187_008583	2.851e-15	89.0	COG3507@1|root,COG3507@2|Bacteria,1R3V6@1224|Proteobacteria	1224|Proteobacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
SX3_k127_6052635_16	269799.Gmet_1299	2.319e-05	56.0	COG3170@1|root,COG3170@2|Bacteria,1Q4NY@1224|Proteobacteria,42ZIW@68525|delta/epsilon subdivisions,2WUTH@28221|Deltaproteobacteria,43UQ3@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
SX3_k127_6052635_17	439481.Aboo_0012	0.0005093	50.0	arCOG13491@1|root,arCOG13491@2157|Archaea,2Y6ZH@28890|Euryarchaeota,3F305@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_6052635_4	1236689.MMALV_13720	3.08e-53	191.0	COG1945@1|root,arCOG04490@2157|Archaea	2157|Archaea	S	Pyruvoyl-dependent arginine decarboxylase	pdaD	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2039	PvlArgDC
SX3_k127_6052635_13	215803.DB30_3742	6.125e-12	80.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3,PKD,Peptidase_S8
SX3_k127_6052635_14	1218084.BBJK01000085_gene5725	1.518e-09	72.0	COG4409@1|root,COG4409@2|Bacteria,1MVUD@1224|Proteobacteria,2VIYQ@28216|Betaproteobacteria,1K3MK@119060|Burkholderiaceae	28216|Betaproteobacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR,BNR_2
SX3_k127_6052635_9	439481.Aboo_0215	1.314e-24	109.0	COG1719@1|root,arCOG01688@2157|Archaea	2157|Archaea	K	PFAM 4-vinyl reductase, 4VR	-	-	-	ko:K07013	-	-	-	-	ko00000	-	-	-	DUF2507,V4R
SX3_k127_6052635_8	693661.Arcve_1632	1.18e-27	116.0	COG2018@1|root,arCOG02603@2157|Archaea,2XY6Z@28890|Euryarchaeota	28890|Euryarchaeota	S	Roadblock LC7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
SX3_k127_6052635_3	1125863.JAFN01000001_gene1889	2.622e-60	239.0	COG0457@1|root,COG0457@2|Bacteria,1QXGV@1224|Proteobacteria,42RIF@68525|delta/epsilon subdivisions,2WNC6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
SX3_k127_6052635_12	1121405.dsmv_0737	8.885e-15	89.0	COG1649@1|root,COG2133@1|root,COG2755@1|root,COG3023@1|root,COG3250@1|root,COG3291@1|root,COG1649@2|Bacteria,COG2133@2|Bacteria,COG2755@2|Bacteria,COG3023@2|Bacteria,COG3250@2|Bacteria,COG3291@2|Bacteria,1R2HQ@1224|Proteobacteria,42ZN7@68525|delta/epsilon subdivisions,2WUV4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	GM	PFAM Di-glucose binding within endoplasmic reticulum	-	-	-	-	-	-	-	-	-	-	-	-	Malectin
SX3_k127_6052635_7	374847.Kcr_0727	6.448e-29	136.0	COG3291@1|root,arCOG02508@2157|Archaea	2157|Archaea	G	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,Malectin,PKD
SX3_k127_6052635_5	269797.Mbar_A3266	1.239e-42	163.0	COG0778@1|root,arCOG00288@2157|Archaea,2Y6YN@28890|Euryarchaeota,2NB04@224756|Methanomicrobia	224756|Methanomicrobia	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SX3_k127_6052635_6	1150864.MILUP08_46704	1.189e-36	143.0	COG0853@1|root,COG0853@2|Bacteria,2IHTC@201174|Actinobacteria,4DDKS@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
SX3_k127_6052635_1	224325.AF_0596	2.658e-128	423.0	COG1004@1|root,arCOG00253@2157|Archaea,2XTQY@28890|Euryarchaeota,246SR@183980|Archaeoglobi	183980|Archaeoglobi	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
SX3_k127_6052635_15	1227497.C491_04530	1.663e-05	51.0	COG1977@1|root,arCOG00536@2157|Archaea,2XYQA@28890|Euryarchaeota,23WPF@183963|Halobacteria	183963|Halobacteria	H	COG1977 Molybdopterin converting factor, small subunit	moaD2	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
SX3_k127_6052635_0	1265505.ATUG01000002_gene2025	9.553e-303	945.0	COG2414@1|root,COG2414@2|Bacteria,1R76Y@1224|Proteobacteria,42QE3@68525|delta/epsilon subdivisions,2WIIW@28221|Deltaproteobacteria,2MIUU@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
SX3_k127_6052635_11	315749.Bcer98_0772	3.721e-15	83.0	COG2755@1|root,COG2755@2|Bacteria,1V4IB@1239|Firmicutes	1239|Firmicutes	E	PFAM GDSL-like Lipase Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
SX3_k127_6052635_2	272844.PAB0819	9.033e-94	324.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,242SX@183968|Thermococci	183968|Thermococci	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
SX3_k127_6075888_6	743719.PaelaDRAFT_3720	4.421e-24	121.0	COG1572@1|root,COG1572@2|Bacteria,1U2J3@1239|Firmicutes,4IC6K@91061|Bacilli,27274@186822|Paenibacillaceae	91061|Bacilli	S	Domain of unknown function (DUF4091)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4091
SX3_k127_6075888_4	590998.Celf_3038	2.419e-46	194.0	COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria	201174|Actinobacteria	P	PFAM PKD domain containing protein	wcoG	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PKD
SX3_k127_6075888_2	865861.AZSU01000006_gene1375	3.669e-138	450.0	COG0031@1|root,COG0031@2|Bacteria,1UZEQ@1239|Firmicutes,24BCR@186801|Clostridia,36G6F@31979|Clostridiaceae	186801|Clostridia	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SX3_k127_6075888_5	1379698.RBG1_1C00001G0752	3.884e-43	164.0	COG2138@1|root,COG2138@2|Bacteria	2|Bacteria	S	sirohydrochlorin cobaltochelatase activity	cbiX	-	-	-	-	-	-	-	-	-	-	-	CbiX
SX3_k127_6075888_1	706587.Desti_1479	1.193e-176	569.0	COG1024@1|root,COG1024@2|Bacteria,1QY95@1224|Proteobacteria,42N5K@68525|delta/epsilon subdivisions,2WK1G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Enoyl-CoA hydratase isomerase	bamA	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016822,GO:0016823,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901787,GO:1901788	3.7.1.21	ko:K07539	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R05593,R05594,R10696	RC01430,RC01431,RC03237	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
SX3_k127_6075888_0	671143.DAMO_1208	5.811e-247	779.0	COG0365@1|root,COG0365@2|Bacteria,2NNSQ@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acs	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
SX3_k127_6075888_3	555079.Toce_0685	8.038e-76	268.0	COG0285@1|root,COG0285@2|Bacteria,1TPX5@1239|Firmicutes,247PC@186801|Clostridia,42EM6@68295|Thermoanaerobacterales	186801|Clostridia	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
SX3_k127_6095674_4	634498.mru_0392	5.384e-114	379.0	COG1163@1|root,arCOG00358@2157|Archaea,2XTYK@28890|Euryarchaeota,23NP9@183925|Methanobacteria	183925|Methanobacteria	S	C-terminal region of MMR_HSR1 domain	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,MMR_HSR1_Xtn,TGS
SX3_k127_6095674_15	309800.C498_14733	4.581e-07	64.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWHT@28890|Euryarchaeota,23V64@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	gntR	-	-	-	-	-	-	-	-	-	-	-	HTH_24,HTH_5,MarR_2
SX3_k127_6095674_5	565033.GACE_0557	5.092e-110	368.0	COG0505@1|root,arCOG00064@2157|Archaea,2XT0H@28890|Euryarchaeota,245NS@183980|Archaeoglobi	183980|Archaeoglobi	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
SX3_k127_6095674_0	1236689.MMALV_05010	0.0	1269.0	COG0458@1|root,arCOG01594@2157|Archaea,2XTVE@28890|Euryarchaeota	28890|Euryarchaeota	E	Belongs to the CarB family	carB	GO:0000050,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2374	CPSase_L_D2,CPSase_L_D3,MGS
SX3_k127_6095674_10	867903.ThesuDRAFT_00958	2.311e-14	87.0	COG0526@1|root,COG0526@2|Bacteria,1VAPY@1239|Firmicutes,25B5Z@186801|Clostridia,3WDE5@538999|Clostridiales incertae sedis	186801|Clostridia	CO	PFAM AhpC TSA family	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DsbD,Redoxin
SX3_k127_6095674_12	931627.MycrhDRAFT_5918	2.317e-09	66.0	COG0785@1|root,COG0785@2|Bacteria,2I8T6@201174|Actinobacteria,23442@1762|Mycobacteriaceae	201174|Actinobacteria	O	PFAM Cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	DsbD
SX3_k127_6095674_13	387631.Asulf_01949	6.407e-08	67.0	arCOG02537@1|root,arCOG04500@1|root,arCOG06738@1|root,arCOG02537@2157|Archaea,arCOG04500@2157|Archaea,arCOG06738@2157|Archaea	2157|Archaea	O	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,DUF3821,PKD,Peptidase_S8
SX3_k127_6095674_11	483219.LILAB_21555	2.877e-11	78.0	COG2234@1|root,COG2234@2|Bacteria,1MXJC@1224|Proteobacteria,42RKA@68525|delta/epsilon subdivisions,2WUCM@28221|Deltaproteobacteria,2YWU8@29|Myxococcales	28221|Deltaproteobacteria	S	Peptidase family M28	-	-	3.4.11.10	ko:K05994	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M28
SX3_k127_6095674_6	246969.TAM4_1086	1.13e-104	363.0	arCOG03282@1|root,arCOG03282@2157|Archaea,2XVRK@28890|Euryarchaeota,243J5@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
SX3_k127_6095674_3	671143.DAMO_1052	4.716e-115	381.0	COG1085@1|root,COG1085@2|Bacteria,2NQQM@2323|unclassified Bacteria	2|Bacteria	C	Domain of unknown function (DUF4921)	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM0896	DUF4921,GalP_UDP_tr_C,GalP_UDP_transf
SX3_k127_6095674_14	1123008.KB905693_gene1422	7.699e-08	56.0	arCOG05093@1|root,339N6@2|Bacteria,4NYIM@976|Bacteroidetes,2FVF5@200643|Bacteroidia,22YYW@171551|Porphyromonadaceae	976|Bacteroidetes	S	Winged helix-turn-helix domain (DUF2582)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2582
SX3_k127_6095674_2	264732.Moth_1936	2.519e-145	476.0	COG0297@1|root,COG0297@2|Bacteria,1TQ4M@1239|Firmicutes,248G1@186801|Clostridia,42F2U@68295|Thermoanaerobacterales	186801|Clostridia	F	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1,HHH_3
SX3_k127_6095674_1	589865.DaAHT2_0891	0.0	1038.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WJRZ@28221|Deltaproteobacteria,2MJ97@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
SX3_k127_6095674_9	1304874.JAFY01000005_gene1303	1.786e-18	100.0	COG1661@1|root,COG1661@2|Bacteria,3TB6I@508458|Synergistetes	508458|Synergistetes	S	DNA-binding protein with PD1-like DNA-binding motif	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296
SX3_k127_6095674_8	1220534.B655_1387	1.519e-72	270.0	COG0784@1|root,arCOG06537@2157|Archaea,2XWYJ@28890|Euryarchaeota	28890|Euryarchaeota	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	PAS,PAS_4,PAS_9,PadR,Response_reg
SX3_k127_6095674_7	1047013.AQSP01000044_gene246	6.333e-74	268.0	COG3829@1|root,COG3920@1|root,COG3829@2|Bacteria,COG3920@2|Bacteria,2NPS5@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase	pdtaS	-	2.7.13.3,3.1.3.3	ko:K00936,ko:K07315	-	M00839	-	-	ko00000,ko00002,ko01000,ko01001,ko02022,ko03021	-	-	-	HATPase_c,HATPase_c_2,H_kinase_N,HisKA_2,PAS,PAS_9,SpoIIE
SX3_k127_6097168_0	1123508.JH636449_gene7308	4.308e-11	73.0	COG0823@1|root,COG0823@2|Bacteria,2IZKS@203682|Planctomycetes	203682|Planctomycetes	U	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
SX3_k127_6097168_1	1089548.KI783301_gene1779	2.315e-06	61.0	COG3055@1|root,COG4412@1|root,COG5184@1|root,COG3055@2|Bacteria,COG4412@2|Bacteria,COG5184@2|Bacteria,1VW0A@1239|Firmicutes,4HWE6@91061|Bacilli,3WFP4@539002|Bacillales incertae sedis	2|Bacteria	DZ	S-layer homology domain	-	-	3.2.1.18,3.2.1.52,3.2.1.8	ko:K01181,ko:K01186,ko:K12373,ko:K20276	ko00511,ko00513,ko00520,ko00531,ko00600,ko00603,ko00604,ko01100,ko02024,ko04142,map00511,map00513,map00520,map00531,map00600,map00603,map00604,map01100,map02024,map04142	M00079	R00022,R04018,R06004,R11316	RC00028,RC00049,RC00077	ko00000,ko00001,ko00002,ko01000,ko02042,ko03110	-	GH20,GH33	-	DUF1929,DUF4347,F5_F8_type_C,FIVAR,He_PIG,HemolysinCabind,Kelch_1,Kelch_4,Laminin_G_3,SLH
SX3_k127_6107771_1	401526.TcarDRAFT_1836	1.009e-80	275.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,4H379@909932|Negativicutes	909932|Negativicutes	C	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SX3_k127_6107771_6	1122997.AUDD01000004_gene1331	4.57e-07	55.0	COG1977@1|root,COG1977@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	-	-	2.7.7.80,2.8.1.11	ko:K03636,ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF,ThiS
SX3_k127_6107771_3	1033810.HLPCO_001862	2.38e-57	208.0	COG2230@1|root,COG2230@2|Bacteria	2|Bacteria	M	cyclopropane-fatty-acyl-phospholipid synthase	-	-	2.1.1.79	ko:K00574,ko:K15256,ko:K15257	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
SX3_k127_6107771_7	208444.JNYY01000008_gene8804	4.07e-06	58.0	COG4430@1|root,COG4430@2|Bacteria	2|Bacteria	F	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801,OmdA
SX3_k127_6107771_4	1125863.JAFN01000001_gene2091	1.356e-32	138.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31,rRNA_methylase
SX3_k127_6107771_2	706587.Desti_0036	2.86e-68	256.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,42NFG@68525|delta/epsilon subdivisions,2WJGA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
SX3_k127_6107771_5	1125863.JAFN01000001_gene2648	3.319e-27	128.0	COG1142@1|root,COG1142@2|Bacteria,1MWE1@1224|Proteobacteria,42TQV@68525|delta/epsilon subdivisions,2WQAE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11,Fer4_4,Fer4_7
SX3_k127_6107771_0	767817.Desgi_3960	2.429e-202	647.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,260S3@186807|Peptococcaceae	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
SX3_k127_6124350_0	886293.Sinac_7067	1.773e-30	128.0	COG0824@1|root,COG0824@2|Bacteria,2J0BH@203682|Planctomycetes	203682|Planctomycetes	S	thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
SX3_k127_6124350_1	1232437.KL662058_gene3967	3.689e-29	126.0	COG1912@1|root,COG1912@2|Bacteria,1MV99@1224|Proteobacteria,42SHG@68525|delta/epsilon subdivisions,2WP1D@28221|Deltaproteobacteria,2MJYI@213118|Desulfobacterales	28221|Deltaproteobacteria	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
SX3_k127_6174819_9	439481.Aboo_0003	7.755e-45	166.0	COG0231@1|root,arCOG04277@2157|Archaea,2XX3E@28890|Euryarchaeota,3F2PU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Functions by promoting the formation of the first peptide bond	eif5a	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03263	-	-	-	-	ko00000,ko03012	-	-	-	EFP_N,eIF-5a
SX3_k127_6174819_4	673860.AciM339_0004	2.821e-82	282.0	COG0010@1|root,arCOG01700@2157|Archaea,2XTEP@28890|Euryarchaeota,3F2M6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Arginase family	speB	GO:0003674,GO:0003824,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0008783,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	3.5.3.1,3.5.3.11	ko:K01476,ko:K01480	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00133,M00134	R00551,R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
SX3_k127_6174819_6	186497.PF1407	4.676e-60	216.0	COG0528@1|root,arCOG00858@2157|Archaea,2XT3U@28890|Euryarchaeota,242XX@183968|Thermococci	183968|Thermococci	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
SX3_k127_6174819_8	1054217.TALC_01158	2.201e-47	174.0	COG1781@1|root,arCOG04229@2157|Archaea,2XWP4@28890|Euryarchaeota,241SX@183967|Thermoplasmata	183967|Thermoplasmata	F	Involved in allosteric regulation of aspartate carbamoyltransferase	pyrI	-	-	ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002	-	-	-	PyrI,PyrI_C
SX3_k127_6174819_2	439481.Aboo_1121	6.787e-127	413.0	COG0540@1|root,arCOG00911@2157|Archaea,2XSZ7@28890|Euryarchaeota,3F2F5@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	PFAM aspartate ornithine carbamoyltransferase carbamoyl-P binding domain	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1168	OTCace,OTCace_N
SX3_k127_6174819_7	351160.RRC88	2.456e-58	218.0	COG0620@1|root,arCOG01876@2157|Archaea,2XUCW@28890|Euryarchaeota,2NAQD@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Methionine synthase, vitamin-B12 independent	metE	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
SX3_k127_6174819_14	1041930.Mtc_2351	2.422e-10	65.0	COG1531@1|root,arCOG01302@2157|Archaea	2157|Archaea	S	Belongs to the UPF0248 family	-	-	-	ko:K09715	-	-	-	-	ko00000	-	-	-	DUF504
SX3_k127_6174819_12	368408.Tpen_1197	3.607e-15	85.0	COG0668@1|root,arCOG01568@2157|Archaea,2XSS2@28889|Crenarchaeota	28889|Crenarchaeota	M	Mechanosensitive ion channel	-	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel
SX3_k127_6174819_3	273057.SSO2755	1.663e-83	295.0	COG0438@1|root,arCOG01408@2157|Archaea	2157|Archaea	M	Glycosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1
SX3_k127_6174819_5	368407.Memar_2216	7.803e-68	240.0	COG0380@1|root,arCOG02831@2157|Archaea,2XSTE@28890|Euryarchaeota	28890|Euryarchaeota	G	COG0380 Trehalose-6-phosphate synthase	otsA	-	2.4.1.15,2.4.1.347,3.1.3.12	ko:K00697,ko:K16055	ko00500,ko01100,map00500,map01100	-	R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20,Trehalose_PPase
SX3_k127_6174819_1	1047013.AQSP01000140_gene2507	2.692e-156	503.0	COG0438@1|root,COG0438@2|Bacteria,2NQMN@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferases group 1	treT	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1
SX3_k127_6174819_13	1341151.ASZU01000004_gene497	1.625e-10	74.0	COG0477@1|root,COG2814@2|Bacteria,1UI43@1239|Firmicutes,4ISCR@91061|Bacilli,27BDF@186824|Thermoactinomycetaceae	91061|Bacilli	EGP	Major Facilitator Superfamily	yqgE	-	-	ko:K08222	-	-	-	-	ko00000,ko02000	2.A.1.33	-	-	MFS_1
SX3_k127_6174819_10	593750.Metfor_2782	7.138e-21	95.0	COG1141@1|root,arCOG00349@2157|Archaea	2157|Archaea	C	Ferredoxin	fdxA	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	DnaJ,Fer4_13,Fer4_15
SX3_k127_6174819_15	550540.Fbal_0429	1.872e-08	68.0	COG3240@1|root,COG3240@2|Bacteria	2|Bacteria	I	lipase activity	estA	GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0016289,GO:0016290,GO:0016787,GO:0016788,GO:0016790,GO:0047617,GO:0052689	3.1.3.8	ko:K01083,ko:K11018,ko:K12686,ko:K15349,ko:K21831	ko00562,ko05132,map00562,map05132	-	R03371	RC00078	ko00000,ko00001,ko01000,ko02000,ko02042,ko02044	1.B.12.8	-	-	Autotransporter,Lipase_GDSL
SX3_k127_6174819_16	448385.sce5370	8.626e-07	63.0	COG1572@1|root,COG1572@2|Bacteria,1Q29U@1224|Proteobacteria,437WP@68525|delta/epsilon subdivisions,2WYQ0@28221|Deltaproteobacteria,2YUQ2@29|Myxococcales	28221|Deltaproteobacteria	S	CARDB	-	-	-	-	-	-	-	-	-	-	-	-	CARDB
SX3_k127_6174819_17	1392489.JPOL01000002_gene2745	1.039e-06	63.0	COG2133@1|root,COG2911@1|root,COG3291@1|root,COG4932@1|root,COG2133@2|Bacteria,COG2911@2|Bacteria,COG3291@2|Bacteria,COG4932@2|Bacteria,4PKJH@976|Bacteroidetes,1IJAY@117743|Flavobacteriia	976|Bacteroidetes	G	PKD domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,Malectin,PKD
SX3_k127_6174819_11	768672.Desfe_0298	1.709e-19	101.0	COG1533@1|root,arCOG01290@2157|Archaea,2XPQ6@28889|Crenarchaeota	28889|Crenarchaeota	L	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SX3_k127_6174819_0	944480.ATUV01000001_gene602	1.321e-184	592.0	COG2368@1|root,COG2368@2|Bacteria,1PEQG@1224|Proteobacteria	1224|Proteobacteria	Q	4-hydroxyphenylacetate	-	-	-	-	-	-	-	-	-	-	-	-	HpaB,HpaB_N
SX3_k127_6216563_1	1122221.JHVI01000035_gene1177	4.294e-08	66.0	COG2885@1|root,COG2885@2|Bacteria	2|Bacteria	M	chlorophyll binding	-	-	-	ko:K02557,ko:K03286	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1,1.B.6	-	-	OmpA
SX3_k127_6216563_0	240292.Ava_2183	1.347e-11	78.0	COG2319@1|root,COG4249@1|root,COG5635@1|root,COG2319@2|Bacteria,COG4249@2|Bacteria,COG5635@2|Bacteria,1FZVW@1117|Cyanobacteria,1HMS2@1161|Nostocales	1117|Cyanobacteria	T	WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	NACHT,Pentapeptide,WD40
SX3_k127_6221852_4	314271.RB2654_10713	8.445e-58	230.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase,Cadherin,FG-GAP,Glyco_hydro_26,HemolysinCabind,Integrin_beta,Lipase_GDSL_2
SX3_k127_6221852_5	344747.PM8797T_31438	3.197e-34	153.0	COG2268@1|root,COG2885@1|root,COG3209@1|root,COG3210@1|root,COG3291@1|root,COG4254@1|root,COG4932@1|root,COG5276@1|root,COG2268@2|Bacteria,COG2885@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG4254@2|Bacteria,COG4932@2|Bacteria,COG5276@2|Bacteria,2IYH3@203682|Planctomycetes	203682|Planctomycetes	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SdrD_B
SX3_k127_6221852_1	243274.THEMA_05295	1.756e-112	392.0	COG0165@1|root,COG0165@2|Bacteria,2GDVX@200918|Thermotogae	200918|Thermotogae	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Lyase_1
SX3_k127_6221852_0	688269.Theth_1539	5.052e-189	599.0	COG0137@1|root,COG0137@2|Bacteria	2|Bacteria	E	argininosuccinate synthase activity	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iJN678.argG,iSB619.SA_RS04675	Arginosuc_synth
SX3_k127_6221852_3	1054217.TALC_00629	3.003e-108	360.0	COG0002@1|root,arCOG00495@2157|Archaea,2XTC1@28890|Euryarchaeota,2425Z@183967|Thermoplasmata	183967|Thermoplasmata	E	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily	-	-	1.2.1.38	ko:K00145,ko:K05829	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00028,M00031,M00763,M00845	R03443,R09777,R10931	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
SX3_k127_6221852_2	760568.Desku_0346	1.929e-110	370.0	COG1364@1|root,COG1364@2|Bacteria,1TPBP@1239|Firmicutes,2497Q@186801|Clostridia,26184@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
SX3_k127_6221852_6	335543.Sfum_0064	4.199e-10	61.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,42N8G@68525|delta/epsilon subdivisions,2WKBC@28221|Deltaproteobacteria,2MQ75@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
SX3_k127_6242462_0	673860.AciM339_0151	5.191e-74	276.0	arCOG03042@1|root,arCOG03048@1|root,arCOG03042@2157|Archaea,arCOG03048@2157|Archaea,2Y7NV@28890|Euryarchaeota	28890|Euryarchaeota	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
SX3_k127_6242462_3	15368.BRADI3G45710.1	5.308e-06	60.0	COG0457@1|root,KOG0553@2759|Eukaryota,37ZPG@33090|Viridiplantae,3GX7C@35493|Streptophyta,3MATP@4447|Liliopsida,3IUBG@38820|Poales	35493|Streptophyta	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_8
SX3_k127_6242462_2	272134.KB731324_gene1257	1.027e-24	120.0	COG0457@1|root,COG0457@2|Bacteria,1G1U5@1117|Cyanobacteria,1H859@1150|Oscillatoriales	1117|Cyanobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_8
SX3_k127_6242462_1	1094980.Mpsy_2342	7.195e-40	166.0	COG0467@1|root,arCOG01178@2157|Archaea,2Y0GM@28890|Euryarchaeota	28890|Euryarchaeota	T	PFAM GvpD gas vesicle	gvpD	-	-	-	-	-	-	-	-	-	-	-	GvpD
SX3_k127_624376_9	1121405.dsmv_3734	4.053e-25	110.0	COG1545@1|root,COG1545@2|Bacteria,1N4S9@1224|Proteobacteria,42U3D@68525|delta/epsilon subdivisions,2WQNA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
SX3_k127_624376_4	706587.Desti_2250	4.873e-122	402.0	COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,42N6X@68525|delta/epsilon subdivisions,2WJIE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
SX3_k127_624376_5	316067.Geob_0099	1.279e-93	316.0	COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,42QAM@68525|delta/epsilon subdivisions,2WM04@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100,1.1.1.36	ko:K00023,ko:K00059	ko00061,ko00333,ko00630,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00061,map00333,map00630,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212	M00083,M00373,M00572	R01779,R01977,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00103,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SX3_k127_624376_7	1379698.RBG1_1C00001G0904	2.274e-73	255.0	COG1024@1|root,COG1024@2|Bacteria	2|Bacteria	I	Enoyl-CoA hydratase	bamR	-	4.2.1.100	ko:K07537	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R05597	RC03168	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
SX3_k127_624376_3	1379698.RBG1_1C00001G0892	2.173e-126	413.0	COG1062@1|root,COG1062@2|Bacteria	2|Bacteria	C	S-(hydroxymethyl)glutathione dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N
SX3_k127_624376_10	909663.KI867150_gene1753	1.835e-09	61.0	2EK17@1|root,33DRQ@2|Bacteria,1NNYN@1224|Proteobacteria,42WT5@68525|delta/epsilon subdivisions,2WSVU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_624376_1	1379698.RBG1_1C00001G0899	1.552e-210	682.0	COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria,2NNUW@2323|unclassified Bacteria	2|Bacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	bzdV	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6,1.97.1.9	ko:K03388,ko:K12527	ko00450,ko00680,ko01100,ko01120,ko01200,map00450,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R07229,R11928,R11931,R11943,R11944	RC00011,RC02420	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_4,Fer4,Fer4_20,Fer4_7,NADH-G_4Fe-4S_3,NADH_4Fe-4S,Pyr_redox_2
SX3_k127_624376_8	706587.Desti_1475	1.165e-26	114.0	COG0437@1|root,COG0437@2|Bacteria,1NB9E@1224|Proteobacteria,432E5@68525|delta/epsilon subdivisions,2WXSZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_624376_2	1379698.RBG1_1C00001G0897	2.321e-135	435.0	COG1924@1|root,COG1924@2|Bacteria,2NPG0@2323|unclassified Bacteria	2|Bacteria	I	BadF/BadG/BcrA/BcrD ATPase family	hgdC	-	1.3.7.8	ko:K04114	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	BcrAD_BadFG
SX3_k127_624376_6	748247.AZKH_2139	1.012e-78	271.0	COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,2VSQQ@28216|Betaproteobacteria,2KXX8@206389|Rhodocyclales	206389|Rhodocyclales	I	BadF/BadG/BcrA/BcrD ATPase family	-	-	1.3.7.8	ko:K04115	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	BcrAD_BadFG
SX3_k127_624376_0	1379698.RBG1_1C00001G0895	3.754e-211	661.0	COG1775@1|root,COG1775@2|Bacteria	2|Bacteria	E	2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	1.3.7.8	ko:K04113	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
SX3_k127_6245769_1	477974.Daud_0678	3.07e-64	228.0	COG0778@1|root,COG0778@2|Bacteria,1UY72@1239|Firmicutes,248YJ@186801|Clostridia,266KR@186807|Peptococcaceae	186801|Clostridia	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SX3_k127_6245769_0	309801.trd_1170	2.119e-123	416.0	COG0477@1|root,COG2814@2|Bacteria,2GA6K@200795|Chloroflexi,27XGR@189775|Thermomicrobia	189775|Thermomicrobia	P	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
SX3_k127_6245769_4	1151292.QEW_2281	3.049e-33	138.0	COG1309@1|root,COG1309@2|Bacteria,1TPXF@1239|Firmicutes,24F9Q@186801|Clostridia,25U4T@186804|Peptostreptococcaceae	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
SX3_k127_6245769_3	1094980.Mpsy_0644	6.742e-48	196.0	arCOG02542@1|root,arCOG10954@1|root,arCOG02542@2157|Archaea,arCOG10954@2157|Archaea,2XV12@28890|Euryarchaeota	28890|Euryarchaeota	U	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	-	-	-	-	-	-	-	-	-	-	-	-	Glug
SX3_k127_6245769_6	679926.Mpet_1784	3.716e-12	78.0	COG3398@1|root,arCOG02611@2157|Archaea,2XV4M@28890|Euryarchaeota,2NB4N@224756|Methanomicrobia	224756|Methanomicrobia	K	Winged helix-turn-helix DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
SX3_k127_6245769_2	1094980.Mpsy_0644	4.327e-53	210.0	arCOG02542@1|root,arCOG10954@1|root,arCOG02542@2157|Archaea,arCOG10954@2157|Archaea,2XV12@28890|Euryarchaeota	28890|Euryarchaeota	U	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	-	-	-	-	-	-	-	-	-	-	-	-	Glug
SX3_k127_6245769_5	243231.GSU2073	1.415e-16	94.0	COG3209@1|root,COG3227@1|root,COG3391@1|root,COG3209@2|Bacteria,COG3227@2|Bacteria,COG3391@2|Bacteria,1QW4H@1224|Proteobacteria	1224|Proteobacteria	M	Rhs Family	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Autotransporter,Big_3_2,Big_3_5,DUF4082,DUF4347,He_PIG,PT-HINT,RHS_repeat
SX3_k127_6245769_7	1324957.K933_09352	6.796e-11	73.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWHT@28890|Euryarchaeota,23V64@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	gntR	-	-	-	-	-	-	-	-	-	-	-	HTH_24,HTH_5,MarR_2
SX3_k127_6245769_8	1068980.ARVW01000001_gene443	0.0005579	50.0	COG3427@1|root,COG3427@2|Bacteria,2IKHF@201174|Actinobacteria	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
SX3_k127_6260122_11	1121472.AQWN01000006_gene1827	6.474e-67	235.0	COG1148@1|root,COG1249@1|root,COG1148@2|Bacteria,COG1249@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia,2641A@186807|Peptococcaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Pyr_redox_2
SX3_k127_6260122_13	706587.Desti_5587	1.152e-53	201.0	COG1908@1|root,COG1908@2|Bacteria,1RGF7@1224|Proteobacteria,42S3H@68525|delta/epsilon subdivisions,2WNTN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	FlpD
SX3_k127_6260122_8	264732.Moth_1192	2.81e-80	275.0	COG4656@1|root,COG4656@2|Bacteria,1TS9H@1239|Firmicutes,24DQ7@186801|Clostridia,42FJ0@68295|Thermoanaerobacterales	186801|Clostridia	C	Methylene-tetrahydrofolate reductase C terminal	metV	-	-	-	-	-	-	-	-	-	-	iHN637.CLJU_RS18525	MTHFR_C
SX3_k127_6260122_16	552811.Dehly_0134	8.159e-29	126.0	COG1526@1|root,COG1526@2|Bacteria,2G74E@200795|Chloroflexi	200795|Chloroflexi	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
SX3_k127_6260122_17	247490.KSU1_D0808	1.854e-27	117.0	COG1142@1|root,COG1142@2|Bacteria,2J1KZ@203682|Planctomycetes	203682|Planctomycetes	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_7
SX3_k127_6260122_4	246194.CHY_1824	2.901e-205	688.0	COG0369@1|root,COG1151@2|Bacteria,1TRSC@1239|Firmicutes,248HQ@186801|Clostridia,42FJ2@68295|Thermoanaerobacterales	186801|Clostridia	C	Prismane/CO dehydrogenase family	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
SX3_k127_6260122_2	1009370.ALO_06373	4.698e-241	794.0	COG1614@1|root,COG1614@2|Bacteria,1TSWZ@1239|Firmicutes,4H6WE@909932|Negativicutes	909932|Negativicutes	C	CO dehydrogenase/acetyl-CoA synthase complex beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	CdhC
SX3_k127_6260122_7	1009370.ALO_06353	6.618e-89	303.0	COG2069@1|root,COG2069@2|Bacteria,1TSSY@1239|Firmicutes,4H6FX@909932|Negativicutes	909932|Negativicutes	C	CO dehydrogenase/acetyl-CoA synthase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	CdhD
SX3_k127_6260122_6	485916.Dtox_1272	2.13e-135	444.0	COG1456@1|root,COG1456@2|Bacteria,1TPWJ@1239|Firmicutes,24CTU@186801|Clostridia,2607K@186807|Peptococcaceae	186801|Clostridia	C	CO dehydrogenase acetyl-CoA synthase delta subunit	acsC	-	2.1.1.245	ko:K00197	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD,FeS
SX3_k127_6260122_9	555779.Dthio_PD3223	3.877e-76	265.0	COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42Q13@68525|delta/epsilon subdivisions,2WIT3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM dihydropteroate synthase, DHPS	-	-	2.1.1.258	ko:K15023	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R02289,R10243	RC00004,RC00113,RC01144,RC02871,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
SX3_k127_6260122_12	555779.Dthio_PD3240	6.9e-63	224.0	COG3640@1|root,COG3640@2|Bacteria,1R819@1224|Proteobacteria,42PQR@68525|delta/epsilon subdivisions,2WKE4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	PFAM Cobyrinic acid ac-diamide synthase	-	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
SX3_k127_6260122_14	177439.DP0684	2.288e-47	174.0	COG1905@1|root,COG1905@2|Bacteria,1RHBU@1224|Proteobacteria,42U8S@68525|delta/epsilon subdivisions,2WQ8V@28221|Deltaproteobacteria,2MKT7@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit	nuoE-1	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
SX3_k127_6260122_1	386456.JQKN01000009_gene1128	3.567e-263	823.0	COG1894@1|root,COG2221@1|root,arCOG02059@2157|Archaea,arCOG04537@2157|Archaea,2XUYN@28890|Euryarchaeota	28890|Euryarchaeota	C	NADH ubiquinone oxidoreductase, NADH-binding (51 kD) subunit	-	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
SX3_k127_6260122_0	386456.JQKN01000009_gene1131	0.0	1120.0	COG0243@1|root,arCOG01492@2157|Archaea,2Y8AB@28890|Euryarchaeota	28890|Euryarchaeota	C	formate dehydrogenase, alpha subunit	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_21,Fer4_6,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
SX3_k127_6260122_21	633148.Tagg_0582	4.405e-16	79.0	arCOG02240@1|root,arCOG02240@2157|Archaea	2157|Archaea	S	4-oxalocrotonate tautomerase	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
SX3_k127_6260122_18	871963.Desdi_0998	4.777e-26	115.0	COG1456@1|root,COG1456@2|Bacteria,1UN04@1239|Firmicutes,25GTI@186801|Clostridia,267GE@186807|Peptococcaceae	186801|Clostridia	C	Domain of unknown function (DUF3786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3786
SX3_k127_6260122_19	456442.Mboo_2130	1.873e-24	108.0	arCOG08014@1|root,arCOG08014@2157|Archaea,2Y5ZS@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_6260122_3	697281.Mahau_0889	3.924e-221	697.0	COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,247P5@186801|Clostridia,42FHK@68295|Thermoanaerobacterales	186801|Clostridia	F	PFAM formate-tetrahydrofolate ligase FTHFS	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
SX3_k127_6260122_15	351160.RCIX1720	1.655e-31	128.0	COG2832@1|root,arCOG07680@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF454)	-	-	-	ko:K09790	-	-	-	-	ko00000	-	-	-	DUF454
SX3_k127_6260122_22	1232437.KL662015_gene1273	2.863e-08	58.0	COG1532@1|root,COG1532@2|Bacteria,1N9CX@1224|Proteobacteria,42VBQ@68525|delta/epsilon subdivisions,2WRJQ@28221|Deltaproteobacteria,2MM63@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Predicted RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RNA_bind_2
SX3_k127_6260122_10	401526.TcarDRAFT_1748	5.705e-72	252.0	COG3640@1|root,COG3640@2|Bacteria,1TPCY@1239|Firmicutes,4H4QV@909932|Negativicutes	909932|Negativicutes	D	Cobyrinic acid ac-diamide synthase	-	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
SX3_k127_6260122_20	401526.TcarDRAFT_0535	2.094e-22	104.0	COG0746@1|root,COG0746@2|Bacteria,1VA6T@1239|Firmicutes,4H59P@909932|Negativicutes	909932|Negativicutes	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
SX3_k127_6260122_5	1054217.TALC_00617	9.839e-160	527.0	COG0343@1|root,COG1370@1|root,arCOG00989@2157|Archaea,arCOG00991@2157|Archaea,2XTFH@28890|Euryarchaeota,241KS@183967|Thermoplasmata	183967|Thermoplasmata	J	Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs	tgtA	-	2.4.2.48	ko:K18779	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PUA,TGT,TGT_C2
SX3_k127_629203_2	694429.Pyrfu_1766	3.93e-08	58.0	COG0533@1|root,arCOG01185@2157|Archaea,2XQKE@28889|Crenarchaeota	28889|Crenarchaeota	T	Mn2 dependent serine threonine protein kinase	-	-	2.7.11.1	ko:K08851	-	-	-	-	ko00000,ko01000,ko01001,ko03016	-	-	-	Pkinase,RIO1
SX3_k127_629203_1	579137.Metvu_0460	1.591e-29	127.0	COG1994@1|root,arCOG00614@2157|Archaea,2XX7B@28890|Euryarchaeota,23QU7@183939|Methanococci	183939|Methanococci	S	PFAM peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_629203_3	33898.JRHJ01000055_gene5777	6.033e-05	56.0	COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,2GMNT@201174|Actinobacteria	201174|Actinobacteria	U	Periplasmic component of the Tol biopolymer transport system	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3,PD40,TAT_signal
SX3_k127_629203_0	555079.Toce_1474	3.54e-105	349.0	COG3643@1|root,COG3643@2|Bacteria,1TP5T@1239|Firmicutes,24905@186801|Clostridia,42EU0@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM Formiminotransferase	ftcD	-	2.1.2.5	ko:K00603	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R03189	RC00165,RC00221,RC00223,RC00870	ko00000,ko00001,ko01000	-	-	-	FTCD,FTCD_N
SX3_k127_629203_4	1121382.JQKG01000074_gene1979	0.0005454	52.0	COG2730@1|root,COG3979@1|root,COG2730@2|Bacteria,COG3979@2|Bacteria	2|Bacteria	S	chitin catabolic process	-	-	3.2.1.4,3.2.1.78	ko:K01179,ko:K01218	ko00051,ko00500,ko01100,ko02024,map00051,map00500,map01100,map02024	-	R01332,R06200,R11307,R11308	RC00467	ko00000,ko00001,ko01000	-	GH26,GH5,GH9	-	Alginate_lyase,CBM_10,CBM_2,CBM_3,Cellulase,fn3
SX3_k127_6295110_0	877455.Metbo_1208	3.151e-95	323.0	COG0476@1|root,arCOG09483@1|root,arCOG01676@2157|Archaea,arCOG09483@2157|Archaea,2XTYV@28890|Euryarchaeota	28890|Euryarchaeota	H	UBA THIF-type NAD FAD binding protein	-	-	2.7.7.73,2.7.7.80	ko:K03148,ko:K21029	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	TBP,ThiF
SX3_k127_6295110_1	351160.RCIX785	1.534e-14	87.0	COG3398@1|root,arCOG02611@2157|Archaea,2XYCT@28890|Euryarchaeota,2N9PX@224756|Methanomicrobia	224756|Methanomicrobia	S	Winged helix-turn-helix DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
SX3_k127_6295110_2	1396141.BATP01000007_gene5788	0.0001409	55.0	2DBSP@1|root,2ZAT9@2|Bacteria,46Z78@74201|Verrucomicrobia,2IWQF@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_6297686_1	573370.DMR_20450	0.0007848	52.0	COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,42MA5@68525|delta/epsilon subdivisions,2WJGZ@28221|Deltaproteobacteria,2M9Y5@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
SX3_k127_6297686_0	439481.Aboo_0345	2.933e-132	428.0	COG0714@1|root,arCOG00434@2157|Archaea,2XSZU@28890|Euryarchaeota	28890|Euryarchaeota	S	ATPase associated with various cellular activities	moxR2	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
SX3_k127_6373925_2	439481.Aboo_1455	2.181e-119	395.0	COG1180@1|root,arCOG00946@2157|Archaea,2XUB7@28890|Euryarchaeota,3F2I4@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Radical SAM	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
SX3_k127_6373925_1	1094980.Mpsy_1916	9.178e-147	472.0	COG1759@1|root,arCOG04346@2157|Archaea,2XUFR@28890|Euryarchaeota,2N9G6@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates	purP	-	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
SX3_k127_6373925_0	706587.Desti_4338	3.303e-170	542.0	COG2502@1|root,COG2502@2|Bacteria,1MVWF@1224|Proteobacteria	1224|Proteobacteria	E	aspartate--ammonia ligase	asnA	GO:0003674,GO:0003824,GO:0004071,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006529,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009987,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.1.1	ko:K01914	ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230	-	R00483	RC00010	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_2719,iECOK1_1307.ECOK1_4193,iECS88_1305.ECS88_4166,iUMN146_1321.UM146_18910,iUTI89_1310.UTI89_C4299	AsnA,tRNA-synt_2
SX3_k127_6373925_3	368407.Memar_2425	6.047e-20	90.0	arCOG03272@1|root,arCOG03272@2157|Archaea,2Y1VM@28890|Euryarchaeota,2NA39@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	2.7.7.6	ko:K00960	-	-	-	-	ko00000,ko01000	-	-	-	-
SX3_k127_640308_1	215803.DB30_3980	2.387e-24	105.0	COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,42NIA@68525|delta/epsilon subdivisions,2WM87@28221|Deltaproteobacteria,2YUDN@29|Myxococcales	28221|Deltaproteobacteria	HJ	Belongs to the RimK family	rimK	-	6.3.2.32	ko:K05844,ko:K14940	ko00680,ko01120,map00680,map01120	-	R09401	RC00064,RC00090	ko00000,ko00001,ko01000,ko03009	-	-	-	RimK
SX3_k127_640308_0	439481.Aboo_1259	6.404e-96	326.0	COG0552@1|root,arCOG01227@2157|Archaea,2XUBI@28890|Euryarchaeota,3F2GR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
SX3_k127_640308_4	453591.Igni_0087	3.476e-06	55.0	COG1730@1|root,arCOG01341@2157|Archaea	2157|Archaea	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016272,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032991,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K04797	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin
SX3_k127_640308_2	593117.TGAM_1681	1.397e-08	59.0	COG2157@1|root,arCOG04175@2157|Archaea,2Y0R1@28890|Euryarchaeota,244JC@183968|Thermococci	183968|Thermococci	J	rRNA binding	rplX	-	-	ko:K02944	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18A
SX3_k127_640308_3	504728.K649_10085	7.899e-08	66.0	COG2319@1|root,COG2319@2|Bacteria,1WK2V@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	WD40 repeats	-	-	-	-	-	-	-	-	-	-	-	-	WD40
SX3_k127_6412932_2	273057.SSO2195	1.441e-52	197.0	COG0330@1|root,arCOG01915@2157|Archaea,2XPQN@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
SX3_k127_6412932_5	1163407.UU7_12621	3.199e-13	84.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,1X43X@135614|Xanthomonadales	135614|Xanthomonadales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamB	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
SX3_k127_6412932_3	215803.DB30_4251	2.396e-22	114.0	COG1404@1|root,COG3055@1|root,COG3291@1|root,COG3509@1|root,COG5295@1|root,COG1404@2|Bacteria,COG3055@2|Bacteria,COG3291@2|Bacteria,COG3509@2|Bacteria,COG5295@2|Bacteria,1Q4PP@1224|Proteobacteria,42YRG@68525|delta/epsilon subdivisions,2WUJR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Bacterial Ig-like domain (group 3)	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3
SX3_k127_6412932_7	1380394.JADL01000002_gene1787	2.046e-08	66.0	COG2885@1|root,COG2885@2|Bacteria,1R508@1224|Proteobacteria,2U3SZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
SX3_k127_6412932_6	1459636.NTE_02332	7.252e-12	77.0	arCOG10526@1|root,arCOG10526@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_6412932_0	316067.Geob_3303	1.299e-173	555.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2WIY6@28221|Deltaproteobacteria,43UHV@69541|Desulfuromonadales	28221|Deltaproteobacteria	JKL	helicase superfamily c-terminal domain	rhlE-2	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
SX3_k127_6412932_4	368407.Memar_2425	1.353e-19	91.0	arCOG03272@1|root,arCOG03272@2157|Archaea,2Y1VM@28890|Euryarchaeota,2NA39@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	2.7.7.6	ko:K00960	-	-	-	-	ko00000,ko01000	-	-	-	-
SX3_k127_6412932_1	373903.Hore_11100	3.915e-57	205.0	COG2309@1|root,COG2309@2|Bacteria,1UMYG@1239|Firmicutes,24BYI@186801|Clostridia,3WBF0@53433|Halanaerobiales	186801|Clostridia	E	Thermophilic metalloprotease (M29)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M29
SX3_k127_6488201_0	439481.Aboo_1131	4.2e-220	696.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,3F2FS@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	TCP-1/cpn60 chaperonin family	thsA	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
SX3_k127_6488201_1	555088.DealDRAFT_0928	5.61e-118	392.0	COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,248EM@186801|Clostridia,42JKT@68298|Syntrophomonadaceae	186801|Clostridia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
SX3_k127_6503737_0	926560.KE387023_gene1413	6.454e-06	59.0	COG3693@1|root,COG3828@1|root,COG3693@2|Bacteria,COG3828@2|Bacteria	2|Bacteria	N	Trehalose utilisation	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM9_1,CBM_2,CBM_3,CBM_4_9,CBM_6,Glyco_hydro_10,Glyco_hydro_48,Ricin_B_lectin,VCBS,fn3
SX3_k127_6507334_2	304371.MCP_1854	1.305e-13	71.0	COG2309@1|root,arCOG01890@2157|Archaea,2XU28@28890|Euryarchaeota	28890|Euryarchaeota	E	Leucyl aminopeptidase (Aminopeptidase t)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M29
SX3_k127_6507334_0	1054217.TALC_00023	3.13e-25	113.0	COG1777@1|root,arCOG01684@2157|Archaea,2Y680@28890|Euryarchaeota,241VW@183967|Thermoplasmata	183967|Thermoplasmata	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
SX3_k127_6507334_1	452637.Oter_3066	1.663e-17	95.0	COG2911@1|root,COG3209@1|root,COG2911@2|Bacteria,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	DctA-YdbH
SX3_k127_6517281_3	411902.CLOBOL_06597	1.769e-08	67.0	COG1277@1|root,COG1277@2|Bacteria,1TQM9@1239|Firmicutes,249MZ@186801|Clostridia,222CQ@1506553|Lachnoclostridium	186801|Clostridia	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
SX3_k127_6517281_0	1183377.Py04_1219	6.748e-64	231.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT0T@28890|Euryarchaeota,242X5@183968|Thermococci	183968|Thermococci	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SX3_k127_6517281_2	926560.KE387023_gene1413	1.708e-09	66.0	COG3693@1|root,COG3828@1|root,COG3693@2|Bacteria,COG3828@2|Bacteria	2|Bacteria	N	Trehalose utilisation	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM9_1,CBM_2,CBM_3,CBM_4_9,CBM_6,Glyco_hydro_10,Glyco_hydro_48,Ricin_B_lectin,VCBS,fn3
SX3_k127_6517281_1	195250.CM001776_gene2888	5.671e-15	89.0	COG2304@1|root,COG3209@1|root,COG2304@2|Bacteria,COG3209@2|Bacteria,1GJ0D@1117|Cyanobacteria,1H29D@1129|Synechococcus	1117|Cyanobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,RHS_repeat,SdrD_B
SX3_k127_664218_5	72019.SARC_11303T0	4.876e-14	84.0	KOG0379@1|root,KOG4293@1|root,KOG0379@2759|Eukaryota,KOG4293@2759|Eukaryota	2759|Eukaryota	U	DOMON domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B561,Kelch_3,Kelch_4
SX3_k127_664218_2	1236689.MMALV_05760	6.695e-109	367.0	COG0152@1|root,arCOG04421@2157|Archaea,2XTW4@28890|Euryarchaeota,3F2G7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
SX3_k127_664218_3	1297742.A176_00262	3.978e-36	160.0	COG1470@1|root,COG2885@1|root,COG4719@1|root,COG1470@2|Bacteria,COG2885@2|Bacteria,COG4719@2|Bacteria,1MX1F@1224|Proteobacteria,42UTB@68525|delta/epsilon subdivisions,2WQUW@28221|Deltaproteobacteria,2YUE1@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,DUF11,OmpA,Phenol_MetA_deg,TSP_3
SX3_k127_664218_4	1254432.SCE1572_40550	6.693e-15	90.0	COG3055@1|root,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF3494,Kelch_1,Kelch_3,Kelch_4,Laminin_G_3
SX3_k127_664218_0	604354.TSIB_0936	5.089e-195	626.0	COG1003@1|root,arCOG00076@2157|Archaea,2XT3V@28890|Euryarchaeota,242MV@183968|Thermococci	183968|Thermococci	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
SX3_k127_664218_1	673860.AciM339_0362	3.282e-128	426.0	COG0403@1|root,arCOG00077@2157|Archaea,2XT39@28890|Euryarchaeota,3F362@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Glycine cleavage system P-protein	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
SX3_k127_664218_6	1121335.Clst_1647	0.0004328	50.0	COG3507@1|root,COG3867@1|root,COG4733@1|root,COG4932@1|root,COG3507@2|Bacteria,COG3867@2|Bacteria,COG4733@2|Bacteria,COG4932@2|Bacteria,1TQDZ@1239|Firmicutes,24CPM@186801|Clostridia,3WHFY@541000|Ruminococcaceae	186801|Clostridia	G	Arabinogalactan endo-beta-1,4-galactanase	-	-	3.2.1.89	ko:K01224	-	-	-	-	ko00000,ko01000	-	-	-	CarboxypepD_reg,Dockerin_1,Glyco_hydro_53
SX3_k127_6646081_6	756499.Desde_2253	6.507e-14	74.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,260DA@186807|Peptococcaceae	186801|Clostridia	C	PFAM 2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
SX3_k127_6646081_1	1236689.MMALV_01900	6.315e-113	372.0	COG2759@1|root,arCOG04538@2157|Archaea,2XTE0@28890|Euryarchaeota,3F2M9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
SX3_k127_6646081_0	439481.Aboo_0964	8.005e-119	396.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,3F31W@33867|unclassified Euryarchaeota	28890|Euryarchaeota	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ1	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
SX3_k127_6646081_5	269799.Gmet_0933	3.309e-16	93.0	COG2304@1|root,COG2373@1|root,COG3391@1|root,COG2304@2|Bacteria,COG2373@2|Bacteria,COG3391@2|Bacteria,1QU09@1224|Proteobacteria	1224|Proteobacteria	M	regulator of chromosome condensation, RCC1	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,Cadherin,He_PIG,RHS_repeat
SX3_k127_6646081_3	1041930.Mtc_0068	4.334e-54	196.0	COG0197@1|root,arCOG04113@2157|Archaea,2XTHT@28890|Euryarchaeota,2N9MZ@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the universal ribosomal protein uL16 family	rpl10e	-	-	ko:K02866	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
SX3_k127_6646081_2	765420.OSCT_0452	1.136e-61	240.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,2G699@200795|Chloroflexi,3766E@32061|Chloroflexia	32061|Chloroflexia	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,TPR_12
SX3_k127_6646081_7	1206735.BAGG01000068_gene3025	1.312e-06	62.0	COG0457@1|root,COG3903@1|root,COG0457@2|Bacteria,COG3903@2|Bacteria,2GIRS@201174|Actinobacteria,4FZD8@85025|Nocardiaceae	201174|Actinobacteria	K	NB-ARC domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,NB-ARC,SEFIR,TPR_10,TPR_12,TPR_7,Trans_reg_C
SX3_k127_6646081_4	391623.TERMP_01574	8.353e-26	125.0	COG0457@1|root,COG0640@1|root,COG1672@1|root,arCOG01679@2157|Archaea,arCOG03045@2157|Archaea,arCOG03169@2157|Archaea,2Y1R2@28890|Euryarchaeota,242W9@183968|Thermococci	183968|Thermococci	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,TPR_8
SX3_k127_6714953_2	673860.AciM339_0394	3.355e-05	56.0	arCOG05363@1|root,arCOG05363@2157|Archaea,2Y07M@28890|Euryarchaeota,3F2V9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
SX3_k127_6714953_0	1124780.ANNU01000073_gene708	1.646e-55	203.0	COG0170@1|root,COG0170@2|Bacteria,4P0IJ@976|Bacteroidetes,47TKF@768503|Cytophagia	976|Bacteroidetes	I	dolichyl monophosphate biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_6714953_1	986075.CathTA2_1881	2.578e-36	149.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli	91061|Bacilli	IQ	reductase	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iYO844.BSU15910	adh_short_C2
SX3_k127_6714953_3	1086011.HJ01_03473	0.0004845	45.0	2EFZF@1|root,339RM@2|Bacteria,4NXMV@976|Bacteroidetes,1IDAM@117743|Flavobacteriia,2NXW9@237|Flavobacterium	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TspO_MBR
SX3_k127_6737070_4	880073.Calab_0825	4.187e-22	112.0	COG1404@1|root,COG3637@1|root,COG1404@2|Bacteria,COG3637@2|Bacteria,2NPDC@2323|unclassified Bacteria	2|Bacteria	O	Peptidase S8	-	-	3.4.21.66	ko:K08651	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	DUF3138,Peptidase_S8
SX3_k127_6737070_3	880073.Calab_2183	6.805e-23	117.0	COG3210@1|root,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Cadherin,Calx-beta,DUF5122,Haemagg_act,HemolysinCabind,PPC,VCBS
SX3_k127_6737070_0	529709.PYCH_07400	4.825e-112	385.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,243BD@183968|Thermococci	183968|Thermococci	K	Fibronectin-binding protein A N-terminus (FbpA)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
SX3_k127_6737070_7	7209.EFO19615.1	1.777e-13	79.0	KOG0080@1|root,KOG0080@2759|Eukaryota,38EZ7@33154|Opisthokonta,3BB89@33208|Metazoa,3CXE2@33213|Bilateria,40D0I@6231|Nematoda,1KVM6@119089|Chromadorea	33208|Metazoa	U	Plays a role in apical endocytosis recycling. May be implicated in transport between the plasma membrane and early endosomes (By similarity)	RAB18	GO:0000166,GO:0001654,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005794,GO:0006810,GO:0006913,GO:0006996,GO:0007029,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0007423,GO:0008150,GO:0009790,GO:0009792,GO:0009987,GO:0010256,GO:0012505,GO:0016043,GO:0017076,GO:0019001,GO:0019003,GO:0031984,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034389,GO:0036094,GO:0043009,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0046907,GO:0048513,GO:0048731,GO:0048856,GO:0051169,GO:0051170,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0060322,GO:0071782,GO:0071786,GO:0071840,GO:0097159,GO:0097367,GO:0098827,GO:1901265,GO:1901363	-	ko:K07910	-	-	-	-	ko00000,ko04031,ko04131	-	-	-	Ras
SX3_k127_6737070_5	1463887.KL589953_gene25	1.082e-20	99.0	COG0517@1|root,COG0517@2|Bacteria,2GKSH@201174|Actinobacteria	201174|Actinobacteria	C	Cbs domain	-	-	-	-	-	-	-	-	-	-	-	-	BON,CBS
SX3_k127_6737070_6	1444309.JAQG01000022_gene1472	3.388e-17	90.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	MA20_13990	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	Lactamase_B
SX3_k127_6737070_10	797210.Halxa_3209	0.0003578	52.0	COG0382@1|root,arCOG00481@2157|Archaea	2157|Archaea	H	COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	UbiA
SX3_k127_6737070_8	765420.OSCT_0650	1.588e-08	66.0	2DWHV@1|root,340DF@2|Bacteria	2|Bacteria	M	UbiA prenyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	UbiA
SX3_k127_6737070_9	1150469.RSPPHO_02770	0.0001932	53.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,2TT3I@28211|Alphaproteobacteria,2JPRK@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
SX3_k127_6737070_2	660470.Theba_2261	1.964e-43	163.0	2DH26@1|root,2ZY4Z@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
SX3_k127_6737070_1	596152.DesU5LDRAFT_3000	5.759e-87	292.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,42N8V@68525|delta/epsilon subdivisions,2WJWB@28221|Deltaproteobacteria,2M9ST@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
SX3_k127_68007_1	706587.Desti_0172	2.08e-75	263.0	COG2048@1|root,COG2048@2|Bacteria,1RC7G@1224|Proteobacteria,43B85@68525|delta/epsilon subdivisions,2WMVG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Heterodisulfide reductase subunit B	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
SX3_k127_68007_2	880072.Desac_0835	8.64e-61	218.0	COG1908@1|root,COG2512@1|root,COG1908@2|Bacteria,COG2512@2|Bacteria,1RCZY@1224|Proteobacteria,42TFE@68525|delta/epsilon subdivisions,2WPDR@28221|Deltaproteobacteria,2MRBM@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	FlpD
SX3_k127_68007_0	387631.Asulf_01816	0.0	1103.0	COG1148@1|root,arCOG02234@2157|Archaea,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,245U1@183980|Archaeoglobi	183980|Archaeoglobi	C	Heterodisulfide reductase subunit A and related polyferredoxins	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,FlpD,Pyr_redox_2
SX3_k127_684693_3	326427.Cagg_3152	1.374e-07	65.0	COG1361@1|root,COG1470@1|root,COG1361@2|Bacteria,COG1470@2|Bacteria,2GA7Y@200795|Chloroflexi,376PQ@32061|Chloroflexia	32061|Chloroflexia	M	SMART Parallel beta-helix repeat	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NPCBM_assoc
SX3_k127_684693_4	326427.Cagg_3152	1.103e-05	59.0	COG1361@1|root,COG1470@1|root,COG1361@2|Bacteria,COG1470@2|Bacteria,2GA7Y@200795|Chloroflexi,376PQ@32061|Chloroflexia	32061|Chloroflexia	M	SMART Parallel beta-helix repeat	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NPCBM_assoc
SX3_k127_684693_1	1121468.AUBR01000015_gene2248	5.144e-82	297.0	COG0826@1|root,COG0826@2|Bacteria,1TQS1@1239|Firmicutes,24909@186801|Clostridia,42EQS@68295|Thermoanaerobacterales	186801|Clostridia	O	PFAM peptidase U32	ydcP	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
SX3_k127_684693_0	394503.Ccel_2428	5.027e-91	314.0	COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,2488G@186801|Clostridia,36E1H@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
SX3_k127_684693_2	1437824.BN940_09676	1.564e-33	148.0	COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,2VJA4@28216|Betaproteobacteria,3T1FN@506|Alcaligenaceae	28216|Betaproteobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
SX3_k127_686907_1	1089548.KI783301_gene1779	8.599e-55	218.0	COG3055@1|root,COG4412@1|root,COG5184@1|root,COG3055@2|Bacteria,COG4412@2|Bacteria,COG5184@2|Bacteria,1VW0A@1239|Firmicutes,4HWE6@91061|Bacilli,3WFP4@539002|Bacillales incertae sedis	2|Bacteria	DZ	S-layer homology domain	-	-	3.2.1.18,3.2.1.52,3.2.1.8	ko:K01181,ko:K01186,ko:K12373,ko:K20276	ko00511,ko00513,ko00520,ko00531,ko00600,ko00603,ko00604,ko01100,ko02024,ko04142,map00511,map00513,map00520,map00531,map00600,map00603,map00604,map01100,map02024,map04142	M00079	R00022,R04018,R06004,R11316	RC00028,RC00049,RC00077	ko00000,ko00001,ko00002,ko01000,ko02042,ko03110	-	GH20,GH33	-	DUF1929,DUF4347,F5_F8_type_C,FIVAR,He_PIG,HemolysinCabind,Kelch_1,Kelch_4,Laminin_G_3,SLH
SX3_k127_686907_5	102129.Lepto7375DRAFT_0842	5.559e-18	99.0	COG1572@1|root,COG3209@1|root,COG1572@2|Bacteria,COG3209@2|Bacteria,1G4UG@1117|Cyanobacteria,1HH6U@1150|Oscillatoriales	1117|Cyanobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,RHS_repeat
SX3_k127_686907_4	304371.MCP_2098	1.07e-21	97.0	arCOG03272@1|root,arCOG03272@2157|Archaea,2Y1VM@28890|Euryarchaeota,2NA39@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_686907_0	673860.AciM339_1452	1.25e-65	239.0	COG0697@1|root,arCOG00272@2157|Archaea,2Y6Z7@28890|Euryarchaeota,3F2Z3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SX3_k127_686907_7	1480694.DC28_04080	1.715e-09	72.0	COG0841@1|root,COG3420@1|root,COG0841@2|Bacteria,COG3420@2|Bacteria,2J58E@203691|Spirochaetes	203691|Spirochaetes	P	this gene contains a nucleotide ambiguity which may be the result of a sequencing error	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,Big_3_3
SX3_k127_686907_3	309799.DICTH_1542	2.34e-31	143.0	COG4902@1|root,COG4902@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DOMON,EB_dh
SX3_k127_686907_2	298386.PBPRB0283	5.906e-50	196.0	COG3218@1|root,COG3218@2|Bacteria,1QWQA@1224|Proteobacteria	1224|Proteobacteria	S	Ethylbenzene dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	EB_dh
SX3_k127_712871_3	351160.RCIX128	7.142e-22	110.0	arCOG07446@1|root,arCOG07446@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_712871_1	304371.MCP_2734	1.32e-96	325.0	arCOG03776@1|root,arCOG03776@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TF_Zn_Ribbon
SX3_k127_712871_2	304371.MCP_2735	1.814e-88	298.0	arCOG03776@1|root,arCOG03776@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TF_Zn_Ribbon
SX3_k127_712871_0	536227.CcarbDRAFT_4800	9.008e-131	425.0	COG2768@1|root,COG2768@2|Bacteria,1TQAW@1239|Firmicutes,247IS@186801|Clostridia,36EQY@31979|Clostridiaceae	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4
SX3_k127_73791_3	195522.BD01_2115	9.115e-33	130.0	COG1131@1|root,arCOG00194@2157|Archaea,2XWVA@28890|Euryarchaeota,245AB@183968|Thermococci	183968|Thermococci	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SX3_k127_73791_5	289377.HL41_01760	2.676e-15	85.0	COG1309@1|root,COG1309@2|Bacteria,2GHH2@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
SX3_k127_73791_4	416348.Hlac_2824	1.16e-32	149.0	COG3291@1|root,arCOG02508@2157|Archaea,2XUY6@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,PKD,Pilin_N,SdrD_B
SX3_k127_73791_1	1487953.JMKF01000035_gene1160	5.648e-121	413.0	COG5316@1|root,COG5316@2|Bacteria,1GC63@1117|Cyanobacteria,1HF87@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_73791_0	292415.Tbd_0367	1.873e-150	499.0	COG1392@1|root,COG1392@2|Bacteria,1MW5V@1224|Proteobacteria,2VM9A@28216|Betaproteobacteria,1KRYF@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Phosphate transport regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_73791_2	1089544.KB912942_gene1762	7.854e-121	429.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria,4E0F3@85010|Pseudonocardiales	201174|Actinobacteria	G	PEP-utilising enzyme, mobile domain	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
SX3_k127_73791_6	215803.DB30_3742	4.693e-12	79.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3,PKD,Peptidase_S8
SX3_k127_751399_2	797114.C475_06540	9.082e-17	97.0	COG2304@1|root,arCOG03991@1|root,arCOG09176@1|root,arCOG02902@2157|Archaea,arCOG03991@2157|Archaea,arCOG09176@2157|Archaea,2XVVH@28890|Euryarchaeota,23SGN@183963|Halobacteria	183963|Halobacteria	K	protein containing a von Willebrand factor type A (vWA) domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA
SX3_k127_751399_0	324057.Pjdr2_3565	6.301e-24	121.0	COG2911@1|root,COG3055@1|root,COG3210@1|root,COG3291@1|root,COG5184@1|root,COG2911@2|Bacteria,COG3055@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG5184@2|Bacteria,1UJFG@1239|Firmicutes,4IT82@91061|Bacilli,2779Z@186822|Paenibacillaceae	91061|Bacilli	U	antibiotic catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Kelch_1,Kelch_4,SLH
SX3_k127_751399_1	240016.ABIZ01000001_gene928	1.17e-19	100.0	COG0438@1|root,COG0438@2|Bacteria,46USQ@74201|Verrucomicrobia,2ITPS@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1,Metallophos
SX3_k127_794813_2	368407.Memar_0460	1.024e-58	222.0	COG4826@1|root,arCOG04933@2157|Archaea,2XV8M@28890|Euryarchaeota	28890|Euryarchaeota	O	Belongs to the serpin family	-	GO:0003674,GO:0004857,GO:0004866,GO:0004867,GO:0005575,GO:0005576,GO:0005615,GO:0008150,GO:0009892,GO:0010466,GO:0010605,GO:0010951,GO:0019222,GO:0030162,GO:0030234,GO:0030414,GO:0031323,GO:0031324,GO:0032268,GO:0032269,GO:0043086,GO:0044092,GO:0044421,GO:0045861,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051336,GO:0051346,GO:0052547,GO:0052548,GO:0060255,GO:0061134,GO:0061135,GO:0065007,GO:0065009,GO:0080090,GO:0098772	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
SX3_k127_794813_0	679926.Mpet_1013	5.475e-109	373.0	COG4826@1|root,arCOG04933@2157|Archaea,2XV8M@28890|Euryarchaeota,2NA7C@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM proteinase inhibitor I4 serpin	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
SX3_k127_794813_6	192952.MM_1007	1.04e-32	134.0	COG1628@1|root,arCOG00928@2157|Archaea,2XXBV@28890|Euryarchaeota,2N9K3@224756|Methanomicrobia	224756|Methanomicrobia	L	Belongs to the UPF0215 family	-	-	-	ko:K09120	-	-	-	-	ko00000	-	-	-	DUF99
SX3_k127_794813_5	673860.AciM339_1239	5.357e-37	147.0	COG1990@1|root,arCOG04228@2157|Archaea,2XYRE@28890|Euryarchaeota,3F2T0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Peptidyl-tRNA hydrolase PTH2	pth	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.1.1.29	ko:K04794	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	PTH2
SX3_k127_794813_7	673860.AciM339_1240	2.933e-16	89.0	COG4743@1|root,arCOG02884@2157|Archaea,2Y72F@28890|Euryarchaeota,3F39B@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function (DUF1616)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1616
SX3_k127_794813_8	1042877.GQS_04320	1.798e-07	66.0	COG1361@1|root,COG1404@1|root,arCOG03610@1|root,arCOG00704@2157|Archaea,arCOG02089@2157|Archaea,arCOG03610@2157|Archaea,2XV8N@28890|Euryarchaeota,243CT@183968|Thermococci	183968|Thermococci	O	Belongs to the peptidase S8 family	pls	GO:0005575,GO:0005623,GO:0031975,GO:0044464	-	-	-	-	-	-	-	-	-	-	CARDB,PPC,Peptidase_S8
SX3_k127_794813_1	1123227.KB899343_gene2055	2.314e-67	238.0	COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,2TU68@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	2.7.1.12,5.3.1.6	ko:K00851,ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056,R01737	RC00002,RC00017,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
SX3_k127_794813_3	1123508.JH636439_gene1131	4.832e-47	197.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,VCBS
SX3_k127_794813_4	272134.KB731325_gene618	1.845e-43	185.0	COG1572@1|root,COG2304@1|root,COG3209@1|root,COG3210@1|root,COG3420@1|root,COG1572@2|Bacteria,COG2304@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,COG3420@2|Bacteria,1G4UG@1117|Cyanobacteria	1117|Cyanobacteria	M	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG
SX3_k127_801263_21	211114.JOEF01000032_gene1956	8.738e-05	57.0	COG1361@1|root,COG3420@1|root,COG1361@2|Bacteria,COG3420@2|Bacteria,2I8F1@201174|Actinobacteria,4E0KV@85010|Pseudonocardiales	201174|Actinobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,He_PIG,fn3
SX3_k127_801263_18	439481.Aboo_1462	3.052e-08	69.0	COG1572@1|root,COG4934@1|root,arCOG02532@2157|Archaea,arCOG03669@2157|Archaea,2Y7X2@28890|Euryarchaeota,3F35Y@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Pro-kumamolisin, activation domain	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,CarboxypepD_reg,Pro-kuma_activ
SX3_k127_801263_19	420247.Msm_0794	3.758e-07	55.0	COG4009@1|root,arCOG04905@2157|Archaea,2Y0I1@28890|Euryarchaeota,23P7W@183925|Methanobacteria	183925|Methanobacteria	S	Domain of unknown function (DUF749)	-	-	-	-	-	-	-	-	-	-	-	-	DUF749
SX3_k127_801263_15	1487923.DP73_04955	6.786e-18	93.0	COG0467@1|root,COG0467@2|Bacteria,1TSIM@1239|Firmicutes,24DRY@186801|Clostridia,260SN@186807|Peptococcaceae	186801|Clostridia	T	KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
SX3_k127_801263_20	443143.GM18_2258	3.836e-06	57.0	COG0457@1|root,COG0457@2|Bacteria,1NK18@1224|Proteobacteria,42SRA@68525|delta/epsilon subdivisions,2WPJQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
SX3_k127_801263_11	673860.AciM339_0287	2.567e-27	123.0	COG0705@1|root,arCOG01768@2157|Archaea,2Y70X@28890|Euryarchaeota,3F340@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
SX3_k127_801263_5	484019.THA_724	8.867e-50	182.0	COG0432@1|root,COG0432@2|Bacteria,2GD2P@200918|Thermotogae	200918|Thermotogae	S	PFAM Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
SX3_k127_801263_3	1459636.NTE_02600	2.186e-68	241.0	COG1701@1|root,arCOG04262@2157|Archaea,41SXP@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Pfam:DUF137	-	-	6.3.2.36	ko:K09722	ko00410,ko00770,ko01100,map00410,map00770,map01100	-	R09379	RC00096,RC00141	ko00000,ko00001,ko01000	-	-	-	PPS_PS
SX3_k127_801263_14	867903.ThesuDRAFT_00800	4.92e-22	113.0	COG4412@1|root,COG4412@2|Bacteria,1TQYP@1239|Firmicutes,24EIE@186801|Clostridia	186801|Clostridia	S	Immune inhibitor A peptidase M6	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M6
SX3_k127_801263_12	935866.JAER01000017_gene4393	2.579e-24	121.0	COG2133@1|root,COG3291@1|root,COG3506@1|root,COG3507@1|root,COG3828@1|root,COG2133@2|Bacteria,COG3291@2|Bacteria,COG3506@2|Bacteria,COG3507@2|Bacteria,COG3828@2|Bacteria,2GJFY@201174|Actinobacteria,4DRVK@85009|Propionibacteriales	201174|Actinobacteria	G	Carbohydrate binding module (family 6)	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,DUF1349,GSDH,PKD,ThuA
SX3_k127_801263_22	926560.KE387023_gene1489	0.0007992	53.0	COG3291@1|root,COG4676@1|root,COG3291@2|Bacteria,COG4676@2|Bacteria	2|Bacteria	UW	Protein conserved in bacteria	-	-	-	ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	CarboxypepD_reg,PKD,TPR_11,TPR_12,TPR_2,TPR_7,TPR_8
SX3_k127_801263_9	1089551.KE386572_gene1743	1.236e-34	147.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,2U12Y@28211|Alphaproteobacteria,4BRG6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
SX3_k127_801263_4	591001.Acfer_1392	1.461e-51	191.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4H2JC@909932|Negativicutes	909932|Negativicutes	IQ	reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SX3_k127_801263_17	311424.DhcVS_969	4.534e-15	79.0	COG0826@1|root,COG0826@2|Bacteria,2GAVB@200795|Chloroflexi,34DF3@301297|Dehalococcoidia	301297|Dehalococcoidia	O	peptidase U32	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_801263_10	314230.DSM3645_11122	4.649e-30	122.0	COG1917@1|root,COG1917@2|Bacteria,2J1N5@203682|Planctomycetes	203682|Planctomycetes	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_801263_1	673860.AciM339_0266	1.263e-81	279.0	COG1235@1|root,arCOG00499@2157|Archaea,2XT48@28890|Euryarchaeota,3F2JB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
SX3_k127_801263_7	1033730.CAHG01000006_gene1226	2.529e-40	173.0	COG0726@1|root,COG3210@1|root,COG3391@1|root,COG0726@2|Bacteria,COG3210@2|Bacteria,COG3391@2|Bacteria,2I6EA@201174|Actinobacteria	201174|Actinobacteria	G	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_801263_13	867903.ThesuDRAFT_00800	1.945e-22	115.0	COG4412@1|root,COG4412@2|Bacteria,1TQYP@1239|Firmicutes,24EIE@186801|Clostridia	186801|Clostridia	S	Immune inhibitor A peptidase M6	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M6
SX3_k127_801263_2	118168.MC7420_3051	1.72e-81	286.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria,1H8AZ@1150|Oscillatoriales	1117|Cyanobacteria	L	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
SX3_k127_801263_0	926569.ANT_16170	8.551e-189	597.0	COG0499@1|root,COG0499@2|Bacteria,2G5X8@200795|Chloroflexi	200795|Chloroflexi	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
SX3_k127_801263_8	289376.THEYE_A0972	1.095e-37	154.0	COG0483@1|root,COG0483@2|Bacteria	2|Bacteria	G	inositol monophosphate 1-phosphatase activity	suhB	-	3.1.3.25,3.1.3.7	ko:K01082,ko:K01092	ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070	M00131	R00188,R00508,R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	Inositol_P
SX3_k127_801263_6	273116.14324441	2.548e-42	175.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y8EG@28890|Euryarchaeota,2424M@183967|Thermoplasmata	183967|Thermoplasmata	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SX3_k127_801263_16	693661.Arcve_1778	2.005e-16	92.0	COG0640@1|root,arCOG01683@2157|Archaea	2157|Archaea	K	regulatory protein, arsR	-	-	-	ko:K13771	ko05132,map05132	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_20,HTH_24,HTH_5,PadR
SX3_k127_816968_0	756499.Desde_4086	5.217e-79	294.0	COG5557@1|root,COG5557@2|Bacteria,1V4C0@1239|Firmicutes,24NSE@186801|Clostridia,264Y6@186807|Peptococcaceae	186801|Clostridia	C	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
SX3_k127_816968_1	1089548.KI783301_gene357	3.819e-63	245.0	COG0437@1|root,COG0437@2|Bacteria,1TT2G@1239|Firmicutes,4HII4@91061|Bacilli	91061|Bacilli	C	4Fe-4S ferredoxin	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_11,Ferredoxin_N
SX3_k127_816968_2	1968.JOEV01000045_gene2266	1.083e-08	66.0	COG4733@1|root,COG4733@2|Bacteria,2HCWC@201174|Actinobacteria	201174|Actinobacteria	Q	PA14 domain	-	-	-	-	-	-	-	-	-	-	-	-	PA14
SX3_k127_816968_3	406124.ACPC01000007_gene3374	1.919e-05	58.0	COG1409@1|root,COG1409@2|Bacteria,1TPQQ@1239|Firmicutes,4HC2W@91061|Bacilli,1ZCF0@1386|Bacillus	91061|Bacilli	Q	Calcineurin-like phosphoesterase	yvnB	-	-	-	-	-	-	-	-	-	-	-	Gram_pos_anchor,LTD,Metallophos,SLH,fn3
SX3_k127_865943_14	706587.Desti_0171	1.217e-45	169.0	COG1150@1|root,COG1150@2|Bacteria,1R44N@1224|Proteobacteria,42NTE@68525|delta/epsilon subdivisions,2WJN8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Nitrate reductase gamma subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	-
SX3_k127_865943_3	429009.Adeg_1885	2.22e-144	497.0	COG1148@1|root,COG1148@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia,42FJG@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S ferredoxin, iron-sulfur binding	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Pyr_redox_2
SX3_k127_865943_4	644281.MFS40622_0209	7.559e-140	458.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23QA9@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
SX3_k127_865943_8	706587.Desti_4262	6.955e-94	321.0	COG0247@1|root,COG0247@2|Bacteria,1R8YC@1224|Proteobacteria,42NJW@68525|delta/epsilon subdivisions,2WIX1@28221|Deltaproteobacteria,2MR23@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
SX3_k127_865943_2	335543.Sfum_1179	6.576e-161	528.0	COG1148@1|root,COG1148@2|Bacteria,1PZ04@1224|Proteobacteria,42PT3@68525|delta/epsilon subdivisions,2WMJU@28221|Deltaproteobacteria,2MR5J@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	FAD dependent oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2
SX3_k127_865943_5	644281.MFS40622_0209	5.749e-132	451.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23QA9@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
SX3_k127_865943_10	335543.Sfum_1176	7.549e-90	308.0	COG0247@1|root,COG0247@2|Bacteria,1R8YC@1224|Proteobacteria,42NJW@68525|delta/epsilon subdivisions,2WIX1@28221|Deltaproteobacteria,2MR23@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
SX3_k127_865943_12	429009.Adeg_2015	1.432e-53	192.0	COG1908@1|root,COG1908@2|Bacteria,1V7I6@1239|Firmicutes,24JV2@186801|Clostridia,42GG4@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD,NADH_4Fe-4S
SX3_k127_865943_0	1121423.JONT01000008_gene701	7.4e-323	1026.0	COG1148@1|root,COG1148@2|Bacteria,1V5YJ@1239|Firmicutes	1239|Firmicutes	C	binding domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,Pyr_redox_2
SX3_k127_865943_13	429009.Adeg_2015	6.039e-50	191.0	COG1908@1|root,COG1908@2|Bacteria,1V7I6@1239|Firmicutes,24JV2@186801|Clostridia,42GG4@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD,NADH_4Fe-4S
SX3_k127_865943_9	335543.Sfum_1176	1.72e-92	321.0	COG0247@1|root,COG0247@2|Bacteria,1R8YC@1224|Proteobacteria,42NJW@68525|delta/epsilon subdivisions,2WIX1@28221|Deltaproteobacteria,2MR23@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
SX3_k127_865943_15	706587.Desti_4261	3.533e-39	150.0	COG1908@1|root,COG1908@2|Bacteria,1RCZY@1224|Proteobacteria	1224|Proteobacteria	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
SX3_k127_865943_7	429009.Adeg_1333	1.745e-109	377.0	COG1148@1|root,COG1148@2|Bacteria,1VPAD@1239|Firmicutes,25B2G@186801|Clostridia,42FM3@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Fer4,Fer4_7,Pyr_redox_2
SX3_k127_865943_18	195250.CM001776_gene591	2.322e-13	80.0	COG0517@1|root,COG0517@2|Bacteria,1G08K@1117|Cyanobacteria,1H0ZY@1129|Synechococcus	1117|Cyanobacteria	S	CP12	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CP12
SX3_k127_865943_19	591158.SSMG_03029	4.134e-07	59.0	COG0517@1|root,COG0517@2|Bacteria,2IM3K@201174|Actinobacteria	201174|Actinobacteria	S	Cbs domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SX3_k127_865943_11	523845.AQXV01000049_gene929	5.524e-73	266.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23Q3U@183939|Methanococci	183939|Methanococci	C	heterodisulfide reductase, subunit B	hdrB2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
SX3_k127_865943_17	868131.MSWAN_1553	9.291e-25	112.0	COG2048@1|root,arCOG00964@2157|Archaea,2XXYP@28890|Euryarchaeota,23NZ8@183925|Methanobacteria	183925|Methanobacteria	C	reductase, subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_8
SX3_k127_865943_1	647113.Metok_0186	2.23e-258	815.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23QA9@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
SX3_k127_865943_20	335543.Sfum_1975	1.394e-06	57.0	COG1908@1|root,COG1908@2|Bacteria	2|Bacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,FlpD,HTH_5
SX3_k127_865943_16	643648.Slip_1398	1.312e-27	122.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
SX3_k127_865943_6	673860.AciM339_0537	1.321e-111	385.0	COG0470@1|root,arCOG00470@2157|Archaea,2XT81@28890|Euryarchaeota,3F2FB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcL	-	-	ko:K04800	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,Rad17
SX3_k127_868603_0	439481.Aboo_0779	6.474e-33	145.0	COG4870@1|root,arCOG02501@1|root,arCOG03439@1|root,arCOG02501@2157|Archaea,arCOG03439@2157|Archaea,arCOG03607@2157|Archaea	2157|Archaea	O	Papain family cysteine protease	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_3,Big_3_5,NosD,PKD,Peptidase_C1,S_layer_C
SX3_k127_868603_1	357808.RoseRS_3027	3.595e-28	128.0	COG1184@1|root,COG1184@2|Bacteria,2G9CC@200795|Chloroflexi,3762Q@32061|Chloroflexia	32061|Chloroflexia	J	Belongs to the eIF-2B alpha beta delta subunits family	-	-	-	ko:K03680	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	IF-2B
SX3_k127_868603_2	660470.Theba_2153	9.426e-18	99.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,DUF285,Flg_new,He_PIG,LVIVD,PKD,RHS_repeat
SX3_k127_868603_3	1249627.D779_3143	1.748e-13	85.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,1RZ6G@1236|Gammaproteobacteria,1X1H2@135613|Chromatiales	135613|Chromatiales	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
SX3_k127_87803_0	269797.Mbar_A2597	1.529e-09	71.0	COG0457@1|root,arCOG06785@1|root,arCOG03047@2157|Archaea,arCOG06785@2157|Archaea,2Y7RD@28890|Euryarchaeota	28890|Euryarchaeota	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_7
SX3_k127_896011_3	192952.MM_2079	1.196e-24	108.0	COG0526@1|root,arCOG01972@2157|Archaea,2XZVP@28890|Euryarchaeota,2NA27@224756|Methanomicrobia	224756|Methanomicrobia	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin
SX3_k127_896011_4	439481.Aboo_0215	2.097e-22	102.0	COG1719@1|root,arCOG01688@2157|Archaea	2157|Archaea	K	PFAM 4-vinyl reductase, 4VR	-	-	-	ko:K07013	-	-	-	-	ko00000	-	-	-	DUF2507,V4R
SX3_k127_896011_6	868131.MSWAN_0370	2.762e-18	98.0	COG1852@1|root,arCOG02078@2157|Archaea,2XWB4@28890|Euryarchaeota,23P3P@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function DUF116	-	-	-	ko:K09729	-	-	-	-	ko00000	-	-	-	DUF116
SX3_k127_896011_0	671143.DAMO_0715	2.075e-56	207.0	COG0351@1|root,COG0351@2|Bacteria,2NP3M@2323|unclassified Bacteria	2|Bacteria	H	Phosphomethylpyrimidine kinase	thiD	GO:0008150,GO:0040007	2.5.1.3,2.7.1.49,2.7.4.7,4.1.99.17	ko:K00941,ko:K03147,ko:K21219	ko00730,ko01100,map00730,map01100	M00127	R03223,R03471,R03472,R04509,R10712	RC00002,RC00017,RC00224,RC03251,RC03252,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
SX3_k127_896011_2	222534.KB893670_gene3882	2.803e-37	165.0	COG3507@1|root,COG3507@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Glyco_hyd_101C,Glyco_hydro_101,Glyco_hydro_43,NPCBM,NPCBM_assoc,RicinB_lectin_2
SX3_k127_896011_1	717606.PaecuDRAFT_2136	1.92e-44	188.0	COG1520@1|root,COG3210@1|root,COG4412@1|root,COG5276@1|root,COG5492@1|root,COG1520@2|Bacteria,COG3210@2|Bacteria,COG4412@2|Bacteria,COG5276@2|Bacteria,COG5492@2|Bacteria,1TR9M@1239|Firmicutes,4HEPP@91061|Bacilli,26T62@186822|Paenibacillaceae	91061|Bacilli	U	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Cadherin-like,Cohesin,Invasin_D3,SLH
SX3_k127_896011_8	1122239.AULS01000019_gene250	9.981e-06	56.0	COG1403@1|root,COG1403@2|Bacteria,2GN1W@201174|Actinobacteria,4FNDI@85023|Microbacteriaceae	201174|Actinobacteria	V	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH,HNH_5
SX3_k127_896011_5	639282.DEFDS_P108	3.823e-21	98.0	COG1943@1|root,COG1943@2|Bacteria,2GGJ9@200930|Deferribacteres	200930|Deferribacteres	L	to the N-terminal region of	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
SX3_k127_897433_1	1278073.MYSTI_01212	2.203e-13	84.0	COG2133@1|root,COG3291@1|root,COG2133@2|Bacteria,COG3291@2|Bacteria,1NIR7@1224|Proteobacteria,433IX@68525|delta/epsilon subdivisions,2WX7K@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PKD domain	-	-	-	-	-	-	-	-	-	-	-	-	PKD
SX3_k127_897433_0	1499967.BAYZ01000119_gene3222	5.016e-136	446.0	COG0174@1|root,COG0174@2|Bacteria,2NNY0@2323|unclassified Bacteria	2|Bacteria	E	glutamine synthetase	glnA2	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
SX3_k127_915637_10	390989.JOEG01000028_gene5509	1.816e-05	57.0	COG1470@1|root,COG3055@1|root,COG4934@1|root,COG1470@2|Bacteria,COG3055@2|Bacteria,COG4934@2|Bacteria,2IF2T@201174|Actinobacteria,4DBYG@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase S8 and S53 subtilisin kexin sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Kelch_1
SX3_k127_915637_8	1500259.JQLD01000002_gene3008	2.242e-27	130.0	COG2202@1|root,COG2982@1|root,COG3209@1|root,COG3210@1|root,COG5295@1|root,COG2202@2|Bacteria,COG2982@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,COG5295@2|Bacteria,1QUXB@1224|Proteobacteria,2TWTY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,DUF4347
SX3_k127_915637_9	1220534.B655_1724	1.078e-15	87.0	COG0011@1|root,arCOG04373@2157|Archaea,2Y0PC@28890|Euryarchaeota,23P8H@183925|Methanobacteria	183925|Methanobacteria	S	Thiamine-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Thiamine_BP
SX3_k127_915637_1	562970.Btus_0928	4.233e-248	784.0	COG2987@1|root,COG2987@2|Bacteria,1TPZ9@1239|Firmicutes,4H9NH@91061|Bacilli,2782U@186823|Alicyclobacillaceae	91061|Bacilli	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
SX3_k127_915637_5	857293.CAAU_2647	5.088e-89	298.0	COG0176@1|root,COG0176@2|Bacteria,1TP4Q@1239|Firmicutes,248KZ@186801|Clostridia,36EK7@31979|Clostridiaceae	186801|Clostridia	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
SX3_k127_915637_6	1280952.HJA_17537	6.172e-71	259.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,2TQKR@28211|Alphaproteobacteria,43X2T@69657|Hyphomonadaceae	28211|Alphaproteobacteria	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
SX3_k127_915637_4	443144.GM21_0478	1.728e-91	317.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NK7@68525|delta/epsilon subdivisions,2WKTV@28221|Deltaproteobacteria,43RYC@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
SX3_k127_915637_0	1047013.AQSP01000091_gene644	1.494e-248	775.0	COG1304@1|root,COG1304@2|Bacteria	2|Bacteria	C	FMN binding	yahG	-	-	-	-	-	-	-	-	-	-	-	DUF1116,FMN_dh,Glu_synthase
SX3_k127_915637_3	1047013.AQSP01000091_gene643	3.062e-100	331.0	COG3383@1|root,COG3383@2|Bacteria,2NNXH@2323|unclassified Bacteria	2|Bacteria	C	Iron hydrogenase small subunit	-	-	1.12.1.3,1.17.1.9,1.6.5.3	ko:K00123,ko:K00336,ko:K18332	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iHN637.CLJU_RS03470	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_21,Fer4_7,NADH-G_4Fe-4S_3
SX3_k127_915637_2	443144.GM21_2804	5.299e-248	784.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	bamH	-	1.6.5.3	ko:K00124,ko:K00335	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_2080	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
SX3_k127_915637_7	1047013.AQSP01000091_gene641	5.939e-46	171.0	COG1905@1|root,COG1905@2|Bacteria,2NPSB@2323|unclassified Bacteria	2|Bacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
SX3_k127_961285_0	1047013.AQSP01000109_gene2443	2.858e-44	164.0	COG1651@1|root,COG1651@2|Bacteria	2|Bacteria	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4,VKOR
SX3_k127_961285_1	1297581.H919_08210	8.514e-20	102.0	COG2340@1|root,COG2340@2|Bacteria,1V6GZ@1239|Firmicutes,4HEGU@91061|Bacilli,21WAG@150247|Anoxybacillus	91061|Bacilli	M	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP
SX3_k127_983960_4	439481.Aboo_0314	1.805e-71	256.0	COG0750@1|root,arCOG04064@2157|Archaea,2XSZP@28890|Euryarchaeota,3F2KK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M50
SX3_k127_983960_5	485916.Dtox_1796	7.053e-54	202.0	COG3481@1|root,COG3481@2|Bacteria,1TPIU@1239|Firmicutes,248SS@186801|Clostridia,261MI@186807|Peptococcaceae	186801|Clostridia	S	PFAM HD domain	-	-	-	ko:K03698	-	-	-	-	ko00000,ko01000,ko03019	-	-	-	HD,tRNA_anti-codon
SX3_k127_983960_17	439481.Aboo_0449	0.0006818	51.0	arCOG01354@1|root,arCOG01354@2157|Archaea,2Y76E@28890|Euryarchaeota,3F3GU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_983960_3	565033.GACE_2162	9.264e-126	409.0	COG0863@1|root,arCOG00115@2157|Archaea,2XT30@28890|Euryarchaeota,246GU@183980|Archaeoglobi	183980|Archaeoglobi	L	DNA methylase	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
SX3_k127_983960_1	673860.AciM339_1081	2.98e-142	466.0	COG0180@1|root,arCOG01887@2157|Archaea,2XSVC@28890|Euryarchaeota,3F2N6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	tRNA synthetases class I (W and Y)	trpS	GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A1374	tRNA-synt_1b
SX3_k127_983960_16	1353276.JADR01000011_gene1557	4.558e-07	62.0	COG4932@1|root,COG4932@2|Bacteria,4NXB2@976|Bacteroidetes	976|Bacteroidetes	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_983960_2	1120973.AQXL01000132_gene2190	5.111e-134	439.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,4H9RJ@91061|Bacilli,2784A@186823|Alicyclobacillaceae	91061|Bacilli	I	Belongs to the thiolase family	atoB	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
SX3_k127_983960_7	667121.ET1_26_00270	9.978e-40	157.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1RP9U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiA	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005623,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0036211,GO:0042597,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0071704,GO:0140096,GO:1901564	5.2.1.8	ko:K01802,ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
SX3_k127_983960_8	1318628.MARLIPOL_06639	3.459e-35	145.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1RP9U@1236|Gammaproteobacteria,467BW@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiA	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005623,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0036211,GO:0042597,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0071704,GO:0140096,GO:1901564	5.2.1.8	ko:K01802,ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
SX3_k127_983960_15	1054217.TALC_00520	2.278e-07	55.0	arCOG05330@1|root,arCOG05330@2157|Archaea,2Y59I@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_983960_14	398767.Glov_0423	2.012e-07	62.0	COG0454@1|root,COG0456@2|Bacteria,1Q4TZ@1224|Proteobacteria,42ZVZ@68525|delta/epsilon subdivisions,2WVEJ@28221|Deltaproteobacteria,43V23@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
SX3_k127_983960_0	273075.Ta1311	2.029e-162	530.0	COG1243@1|root,arCOG01361@2157|Archaea,2XT9Z@28890|Euryarchaeota,241K5@183967|Thermoplasmata	183967|Thermoplasmata	K	Radical_SAM C-terminal domain	-	-	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Radical_SAM,Radical_SAM_C
SX3_k127_983960_10	765913.ThidrDRAFT_1810	1.259e-24	122.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,1RZ6G@1236|Gammaproteobacteria,1X1H2@135613|Chromatiales	135613|Chromatiales	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
SX3_k127_983960_13	880073.Calab_1111	9.303e-16	93.0	COG0308@1|root,COG0308@2|Bacteria,2NPGQ@2323|unclassified Bacteria	2|Bacteria	E	aminopeptidase	pepN1	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
SX3_k127_983960_6	1041930.Mtc_2483	6.573e-41	171.0	COG1784@1|root,arCOG04469@2157|Archaea,2XSZ3@28890|Euryarchaeota,2N9A6@224756|Methanomicrobia	224756|Methanomicrobia	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K08971	-	-	-	-	ko00000	-	-	-	TctA
SX3_k127_983960_9	991905.SL003B_3564	6.943e-34	152.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,2U12Y@28211|Alphaproteobacteria,4BRG6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
SX3_k127_983960_12	1469607.KK073768_gene1110	3.506e-16	83.0	COG0457@1|root,COG0457@2|Bacteria,1G1U5@1117|Cyanobacteria,1HJ1H@1161|Nostocales	1117|Cyanobacteria	M	PFAM Tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
SX3_k127_983960_11	368407.Memar_0477	7.435e-21	100.0	arCOG06069@1|root,arCOG06069@2157|Archaea	2157|Archaea	S	TIGRFAM C_GCAxxG_C_C family	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
SX3_k127_985619_7	1297742.A176_00262	1.02e-27	133.0	COG1470@1|root,COG2885@1|root,COG4719@1|root,COG1470@2|Bacteria,COG2885@2|Bacteria,COG4719@2|Bacteria,1MX1F@1224|Proteobacteria,42UTB@68525|delta/epsilon subdivisions,2WQUW@28221|Deltaproteobacteria,2YUE1@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,DUF11,OmpA,Phenol_MetA_deg,TSP_3
SX3_k127_985619_6	1128421.JAGA01000003_gene2915	4.997e-29	131.0	COG1503@1|root,COG1503@2|Bacteria,2NQ54@2323|unclassified Bacteria	2|Bacteria	J	translation release factor activity	-	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	PP-binding,eRF1_2,eRF1_3
SX3_k127_985619_0	269797.Mbar_A2111	5.359e-67	247.0	COG0608@1|root,arCOG00427@2157|Archaea,2XW5A@28890|Euryarchaeota,2N9D2@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM phosphoesterase, RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHHA1
SX3_k127_985619_3	402880.MmarC5_1830	1.516e-47	175.0	COG0184@1|root,arCOG04185@2157|Archaea,2XWKV@28890|Euryarchaeota,23QST@183939|Methanococci	183939|Methanococci	J	ribosomal protein S15	rps15	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13_N,Ribosomal_S15
SX3_k127_985619_8	635013.TherJR_2578	3.143e-08	65.0	COG1988@1|root,COG1988@2|Bacteria,1TQFC@1239|Firmicutes,24I12@186801|Clostridia,2622F@186807|Peptococcaceae	186801|Clostridia	S	membrane-bound metal-dependent hydrolase (DUF457)	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
SX3_k127_985619_2	387631.Asulf_02277	6.013e-55	205.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,245QE@183980|Archaeoglobi	183980|Archaeoglobi	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
SX3_k127_985619_4	269797.Mbar_A0524	4.425e-47	183.0	arCOG03622@1|root,arCOG03622@2157|Archaea,2Y29P@28890|Euryarchaeota,2NA5X@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SX3_k127_985619_1	1521187.JPIM01000012_gene1661	7.735e-59	236.0	COG3291@1|root,COG3386@1|root,COG3391@1|root,COG3291@2|Bacteria,COG3386@2|Bacteria,COG3391@2|Bacteria,2GAQK@200795|Chloroflexi,3772E@32061|Chloroflexia	32061|Chloroflexia	G	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
SX3_k127_985619_5	28072.Nos7524_5484	1.155e-32	149.0	COG2304@1|root,COG3209@1|root,COG3210@1|root,COG3266@1|root,COG5276@1|root,COG2304@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,COG3266@2|Bacteria,COG5276@2|Bacteria,1G4UG@1117|Cyanobacteria	1117|Cyanobacteria	M	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,RHS_repeat
SX3_k127_993884_1	471853.Bcav_1664	0.0001403	56.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria	201174|Actinobacteria	M	Oxidoreductase molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
SX3_k127_993884_0	1347368.HG964403_gene4490	2.249e-44	188.0	COG4632@1|root,COG5492@1|root,COG4632@2|Bacteria,COG5492@2|Bacteria,1V706@1239|Firmicutes,4IQJJ@91061|Bacilli	91061|Bacilli	N	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
## 2299 queries scanned
## Total time (seconds): 188.98298001289368
## Rate: 12.17 q/s