## Fri Nov 15 16:53:29 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin26/TH_1_bin.8.fa -m mmseqs --itype genome -o TH_1_bin.8 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/TH_1_bin.8 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
TH1_k127_1003837_3	857087.Metme_0346	8.029e-96	321.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria,1XFUI@135618|Methylococcales	135618|Methylococcales	C	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TH1_k127_1003837_1	857087.Metme_0344	6.113e-131	436.0	COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria,1XFZN@135618|Methylococcales	135618|Methylococcales	Q	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
TH1_k127_1003837_4	857087.Metme_0343	6.763e-93	323.0	COG1020@1|root,COG1020@2|Bacteria,1NK69@1224|Proteobacteria,1SKZR@1236|Gammaproteobacteria,1XFVG@135618|Methylococcales	135618|Methylococcales	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_1003837_11	857087.Metme_0342	6.725e-28	114.0	COG0236@1|root,COG0236@2|Bacteria,1QSUN@1224|Proteobacteria,1SRZI@1236|Gammaproteobacteria,1XGM4@135618|Methylococcales	135618|Methylococcales	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
TH1_k127_1003837_6	686340.Metal_3016	2.982e-78	267.0	COG2119@1|root,COG2119@2|Bacteria,1RDDV@1224|Proteobacteria,1S3QT@1236|Gammaproteobacteria,1XEYM@135618|Methylococcales	135618|Methylococcales	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
TH1_k127_1003837_0	697282.Mettu_3984	5.261e-147	471.0	COG0428@1|root,COG0428@2|Bacteria,1MWEZ@1224|Proteobacteria,1RNXU@1236|Gammaproteobacteria,1XE1K@135618|Methylococcales	135618|Methylococcales	P	ZIP Zinc transporter	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
TH1_k127_1003837_5	1116472.MGMO_154c00060	2.343e-88	302.0	COG2013@1|root,COG2013@2|Bacteria,1NBBE@1224|Proteobacteria,1RZ6E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	TIGRFAM TIGR00266 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
TH1_k127_1003837_2	1349767.GJA_4985	6.413e-107	357.0	COG4783@1|root,COG4783@2|Bacteria	2|Bacteria	L	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
TH1_k127_1003837_13	945713.IALB_3055	2.167e-11	68.0	COG1376@1|root,COG1376@2|Bacteria	2|Bacteria	D	ErfK ybiS ycfS ynhG family protein	enhA_1	-	-	-	-	-	-	-	-	-	-	-	PG_binding_4,YkuD
TH1_k127_1003837_10	765911.Thivi_1356	7.004e-30	124.0	2AV75@1|root,31KXS@2|Bacteria,1RKU0@1224|Proteobacteria,1S7D1@1236|Gammaproteobacteria,1WYSC@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF1640)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1640
TH1_k127_1003837_9	1255043.TVNIR_0639	1.4e-36	143.0	COG1848@1|root,COG1848@2|Bacteria	2|Bacteria	G	Toxic component of a toxin-antitoxin (TA) module. An RNase	vapC	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
TH1_k127_1003837_14	324925.Ppha_1441	1.09e-07	57.0	COG1598@1|root,COG1598@2|Bacteria	2|Bacteria	N	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
TH1_k127_1003837_12	1454004.AW11_03755	2.431e-27	113.0	2EH09@1|root,33ASB@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
TH1_k127_1003837_8	1328313.DS2_06416	4.745e-37	140.0	COG2161@1|root,COG2161@2|Bacteria,1N6X6@1224|Proteobacteria,1SDQ0@1236|Gammaproteobacteria,4685U@72275|Alteromonadaceae	1236|Gammaproteobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	yefM	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015643,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042710,GO:0043565,GO:0044010,GO:0044764,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051704,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K19159	-	-	-	-	ko00000,ko02048	-	-	-	PhdYeFM_antitox
TH1_k127_1003837_7	572477.Alvin_0335	4.363e-43	158.0	COG4115@1|root,COG4115@2|Bacteria,1MZBP@1224|Proteobacteria,1S99Z@1236|Gammaproteobacteria,1WYX1@135613|Chromatiales	135613|Chromatiales	S	TIGRFAM Addiction module toxin, Txe YoeB	-	-	-	ko:K19158	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	YoeB_toxin
TH1_k127_1018028_1	697282.Mettu_2685	2.788e-29	121.0	COG2888@1|root,COG2888@2|Bacteria,1PBSP@1224|Proteobacteria,1SWH2@1236|Gammaproteobacteria,1XF87@135618|Methylococcales	135618|Methylococcales	J	Zinc-ribbon containing domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1451
TH1_k127_1018028_0	686340.Metal_2398	0.0	1075.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,1XDZ5@135618|Methylococcales	135618|Methylococcales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
TH1_k127_1026596_2	1116472.MGMO_54c00120	3.367e-18	87.0	COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,1RQPK@1236|Gammaproteobacteria,1XEER@135618|Methylococcales	135618|Methylococcales	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
TH1_k127_1026596_0	857087.Metme_2907	2.801e-199	625.0	COG1180@1|root,COG1180@2|Bacteria,1R8XY@1224|Proteobacteria,1T0C8@1236|Gammaproteobacteria,1XH0M@135618|Methylococcales	135618|Methylococcales	C	Radical SAM superfamily	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
TH1_k127_1026596_1	537972.ABQU01000019_gene667	1.602e-21	96.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2YM7R@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	V	Efflux pump membrane transporter	cmeB	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
TH1_k127_1098908_1	697282.Mettu_1693	7.403e-145	463.0	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,1RM7X@1236|Gammaproteobacteria,1XE8N@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
TH1_k127_1098908_2	686340.Metal_3751	2.566e-31	125.0	COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,1S9AI@1236|Gammaproteobacteria,1XFMQ@135618|Methylococcales	135618|Methylococcales	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
TH1_k127_1098908_0	697282.Mettu_1691	3.834e-189	602.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,1XDSD@135618|Methylococcales	135618|Methylococcales	U	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
TH1_k127_1102455_1	686340.Metal_3214	1.111e-135	440.0	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,1RMJF@1236|Gammaproteobacteria,1XEF2@135618|Methylococcales	135618|Methylococcales	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
TH1_k127_1102455_0	857087.Metme_0581	1.707e-216	681.0	COG2433@1|root,COG2433@2|Bacteria,1QW3W@1224|Proteobacteria,1T2RV@1236|Gammaproteobacteria,1XENI@135618|Methylococcales	135618|Methylococcales	S	Pfam Transposase IS66	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_1102455_2	697282.Mettu_2035	4.277e-64	225.0	COG4659@1|root,COG4659@2|Bacteria,1NP43@1224|Proteobacteria,1RTW5@1236|Gammaproteobacteria,1XF79@135618|Methylococcales	135618|Methylococcales	C	FMN_bind	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind
TH1_k127_1102455_3	105559.Nwat_2933	2.2e-19	89.0	2CKY4@1|root,328RE@2|Bacteria,1N9BF@1224|Proteobacteria,1SNND@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_1102904_0	697282.Mettu_3267	3.13e-291	900.0	COG0119@1|root,COG0119@2|Bacteria,1R7YB@1224|Proteobacteria,1RQB8@1236|Gammaproteobacteria,1XEJD@135618|Methylococcales	135618|Methylococcales	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.1.182	ko:K09011	ko00290,ko00660,ko01100,ko01210,ko01230,map00290,map00660,map01100,map01210,map01230	M00535	R07399	RC00004,RC01205	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
TH1_k127_1102904_1	697282.Mettu_1061	1.644e-18	86.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,1RSNV@1236|Gammaproteobacteria,1XDT8@135618|Methylococcales	135618|Methylococcales	L	DEAD DEAH box	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
TH1_k127_11080_0	857087.Metme_2197	1.187e-213	675.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,1XDT1@135618|Methylococcales	135618|Methylococcales	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
TH1_k127_11080_2	686340.Metal_0513	1.628e-32	126.0	COG1734@1|root,COG1734@2|Bacteria	2|Bacteria	T	zinc ion binding	ybiI	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
TH1_k127_11080_1	697282.Mettu_1609	1.113e-100	334.0	COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,1RMJU@1236|Gammaproteobacteria,1XE1S@135618|Methylococcales	135618|Methylococcales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.5.1.33	ko:K03793	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
TH1_k127_111510_1	697282.Mettu_0462	5.579e-180	569.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,1RMCS@1236|Gammaproteobacteria,1XDT2@135618|Methylococcales	135618|Methylococcales	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
TH1_k127_111510_5	686340.Metal_1128	5.173e-156	496.0	COG0673@1|root,COG0673@2|Bacteria,1MV7C@1224|Proteobacteria,1SYTB@1236|Gammaproteobacteria,1XDPN@135618|Methylococcales	135618|Methylococcales	S	PFAM Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TH1_k127_111510_7	697282.Mettu_2955	4.581e-144	464.0	COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria,1RZ9I@1236|Gammaproteobacteria,1XDNR@135618|Methylococcales	135618|Methylococcales	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
TH1_k127_111510_16	598467.BrE312_3678	5.528e-66	228.0	COG1671@1|root,COG1671@2|Bacteria,1RCZA@1224|Proteobacteria,1S3QM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the UPF0178 family	yaiI	-	-	ko:K09768	-	-	-	-	ko00000	-	-	-	DUF188
TH1_k127_111510_18	1116472.MGMO_94c00570	3.561e-54	197.0	COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,1S3MU@1236|Gammaproteobacteria,1XF19@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
TH1_k127_111510_2	686340.Metal_0530	2.061e-170	539.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,1XE2Q@135618|Methylococcales	135618|Methylococcales	P	PFAM Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TH1_k127_111510_6	1278073.MYSTI_00116	2.209e-150	490.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,42MPR@68525|delta/epsilon subdivisions,2WNM3@28221|Deltaproteobacteria,2YZ2D@29|Myxococcales	28221|Deltaproteobacteria	Q	Multicopper oxidase	-	-	-	ko:K04753	-	-	-	-	ko00000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
TH1_k127_111510_12	686340.Metal_0726	1.435e-121	393.0	COG0412@1|root,COG0412@2|Bacteria,1NKIB@1224|Proteobacteria,1S1VI@1236|Gammaproteobacteria,1XESX@135618|Methylococcales	135618|Methylococcales	Q	PFAM Dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DLH
TH1_k127_111510_10	697282.Mettu_0831	1.542e-123	400.0	COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,1RP6E@1236|Gammaproteobacteria,1XEJI@135618|Methylococcales	135618|Methylococcales	L	TatD related DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
TH1_k127_111510_17	857087.Metme_3485	8.006e-55	196.0	COG3215@1|root,COG3215@2|Bacteria,1RGWZ@1224|Proteobacteria,1S4YE@1236|Gammaproteobacteria,1XF9T@135618|Methylococcales	135618|Methylococcales	NU	PFAM Type IV pilus assembly PilZ	pilZ	-	-	ko:K02676	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilZ
TH1_k127_111510_14	686340.Metal_1613	5.368e-96	325.0	COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,1RNYA@1236|Gammaproteobacteria,1XDVJ@135618|Methylococcales	135618|Methylococcales	L	DNA polymerase III, delta'	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
TH1_k127_111510_15	697282.Mettu_0828	4.874e-82	277.0	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,1S26C@1236|Gammaproteobacteria,1XEZX@135618|Methylococcales	135618|Methylococcales	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
TH1_k127_111510_9	697282.Mettu_0827	1.211e-127	417.0	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,1RMWD@1236|Gammaproteobacteria,1XDXF@135618|Methylococcales	135618|Methylococcales	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
TH1_k127_111510_13	697282.Mettu_0826	8.665e-100	332.0	COG0115@1|root,COG0115@2|Bacteria,1MZAK@1224|Proteobacteria,1RPPG@1236|Gammaproteobacteria,1XEKT@135618|Methylococcales	135618|Methylococcales	EH	PFAM Aminotransferase, class IV	pabC	-	4.1.3.38	ko:K02619	ko00790,map00790	-	R05553	RC01843,RC02148	ko00000,ko00001,ko01000	-	-	-	Aminotran_4
TH1_k127_111510_0	697282.Mettu_0825	5.128e-237	736.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1XE1J@135618|Methylococcales	135618|Methylococcales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TH1_k127_111510_21	686340.Metal_1618	7.517e-35	134.0	COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,1S8X4@1236|Gammaproteobacteria,1XFN1@135618|Methylococcales	135618|Methylococcales	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
TH1_k127_111510_11	1116472.MGMO_146c00190	8.415e-122	394.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,1RMBB@1236|Gammaproteobacteria,1XDSR@135618|Methylococcales	135618|Methylococcales	IQ	3-oxoacyl-(Acyl-carrier-protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TH1_k127_111510_8	697282.Mettu_0822	2.896e-143	462.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,1RNH3@1236|Gammaproteobacteria,1XDSP@135618|Methylococcales	135618|Methylococcales	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
TH1_k127_111510_4	697282.Mettu_0821	3.643e-157	500.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,1XENR@135618|Methylococcales	135618|Methylococcales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
TH1_k127_111510_3	697282.Mettu_0820	2.346e-158	505.0	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,1RM7R@1236|Gammaproteobacteria,1XDYY@135618|Methylococcales	135618|Methylococcales	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
TH1_k127_111510_22	768066.HELO_1995	9.411e-23	98.0	COG0333@1|root,COG0333@2|Bacteria,1N6RF@1224|Proteobacteria,1SC9G@1236|Gammaproteobacteria,1XM5T@135619|Oceanospirillales	135619|Oceanospirillales	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
TH1_k127_111510_19	697282.Mettu_0818	7.847e-45	170.0	COG1399@1|root,COG1399@2|Bacteria,1PGKW@1224|Proteobacteria,1RRK3@1236|Gammaproteobacteria,1XFK3@135618|Methylococcales	135618|Methylococcales	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
TH1_k127_111510_20	697282.Mettu_2191	2.963e-35	140.0	COG3028@1|root,COG3028@2|Bacteria,1MZ4R@1224|Proteobacteria,1S9JJ@1236|Gammaproteobacteria,1XF8X@135618|Methylococcales	135618|Methylococcales	S	Belongs to the UPF0307 family	-	-	-	ko:K09889	-	-	-	-	ko00000,ko03009	-	-	-	DUF615
TH1_k127_111510_23	1116472.MGMO_52c00120	7.684e-14	73.0	2AY0P@1|root,31Q28@2|Bacteria,1QIYS@1224|Proteobacteria,1TGVF@1236|Gammaproteobacteria,1XGT2@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_1173900_7	243233.MCA1656	3.956e-50	181.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,1RQ49@1236|Gammaproteobacteria,1XDY4@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
TH1_k127_1173900_4	857087.Metme_0622	1.137e-76	259.0	COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,1S3WD@1236|Gammaproteobacteria,1XF3G@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
TH1_k127_1173900_6	697282.Mettu_0905	3.534e-62	220.0	COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,1S6AJ@1236|Gammaproteobacteria,1XF41@135618|Methylococcales	135618|Methylococcales	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
TH1_k127_1173900_2	697282.Mettu_0906	3.098e-138	445.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria,1XDIZ@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
TH1_k127_1173900_9	443143.GM18_4371	1.621e-38	146.0	COG1396@1|root,COG1396@2|Bacteria,1N0DD@1224|Proteobacteria	1224|Proteobacteria	K	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
TH1_k127_1173900_8	1286631.X805_28070	3.793e-45	164.0	COG0582@1|root,COG0582@2|Bacteria,1R21C@1224|Proteobacteria,2WI7T@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Domain of unknown function (DUF4160)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4160
TH1_k127_1173900_10	1101195.Meth11DRAFT_2451	1.332e-07	55.0	COG5635@1|root,COG5635@2|Bacteria,1QZXQ@1224|Proteobacteria	1224|Proteobacteria	T	Nacht domain	-	-	-	-	-	-	-	-	-	-	-	-	NACHT,SIR2_2
TH1_k127_1173900_1	686340.Metal_1454	5.709e-178	564.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNN0@1236|Gammaproteobacteria,1XE5B@135618|Methylococcales	1236|Gammaproteobacteria	E	PFAM Aminotransferase, class I	aspC	-	2.6.1.1,2.6.1.84,3.6.3.21	ko:K00812,ko:K02028,ko:K12252	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	M00236	R00355,R00694,R00734,R00896,R02433,R02619,R05052,R08197	RC00006,RC00008	ko00000,ko00001,ko00002,ko01000,ko01007,ko02000	3.A.1.3	-	-	ABC_tran,Aminotran_1_2
TH1_k127_1173900_0	686340.Metal_0374	0.0	1047.0	COG0220@1|root,COG0220@2|Bacteria,1QZB6@1224|Proteobacteria,1T52W@1236|Gammaproteobacteria,1XEH1@135618|Methylococcales	135618|Methylococcales	J	tRNA (guanine-N7-)-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_1173900_3	1000565.METUNv1_00267	2.204e-86	299.0	COG1686@1|root,COG1686@2|Bacteria,1MWZA@1224|Proteobacteria,2VH1S@28216|Betaproteobacteria,2KUX8@206389|Rhodocyclales	206389|Rhodocyclales	M	Belongs to the peptidase S11 family	pbp	-	-	ko:K07262	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
TH1_k127_1173900_5	136993.KB900626_gene3051	1.634e-71	243.0	COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,2U7A8@28211|Alphaproteobacteria,36Y4D@31993|Methylocystaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	gloA	GO:0003674,GO:0003824,GO:0004462,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016846,GO:0034641,GO:0043603,GO:0044237,GO:0051186,GO:0071704,GO:1901564	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
TH1_k127_1184953_0	338963.Pcar_1237	8.042e-76	257.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NK7@68525|delta/epsilon subdivisions,2WKTV@28221|Deltaproteobacteria,43RYC@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
TH1_k127_1184953_1	535289.Dtpsy_2714	4.474e-66	232.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VHUC@28216|Betaproteobacteria,4A9VK@80864|Comamonadaceae	28216|Betaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
TH1_k127_1184953_2	903818.KI912268_gene1067	8.217e-09	56.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	int	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
TH1_k127_1208521_0	686340.Metal_1865	2.823e-85	289.0	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,1RQYC@1236|Gammaproteobacteria,1XEJ1@135618|Methylococcales	135618|Methylococcales	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TH1_k127_1208521_2	1236959.BAMT01000004_gene817	1.809e-51	187.0	COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,2VQ49@28216|Betaproteobacteria,2KME7@206350|Nitrosomonadales	206350|Nitrosomonadales	E	TIGRFAM histidinol-phosphate phosphatase family protein	-	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_like,PNK3P
TH1_k127_1208521_3	1079460.ATTQ01000009_gene683	4.378e-43	175.0	COG3267@1|root,COG3267@2|Bacteria,1MYKB@1224|Proteobacteria,2UPHB@28211|Alphaproteobacteria,4BEIV@82115|Rhizobiaceae	28211|Alphaproteobacteria	U	Protein of unknown function (DUF3365)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365
TH1_k127_1208521_1	1082933.MEA186_08029	7.336e-73	263.0	2DPY8@1|root,333WS@2|Bacteria,1R3GP@1224|Proteobacteria,2U02R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF4239)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4239
TH1_k127_1208521_4	697282.Mettu_3947	8.671e-43	158.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1XENS@135618|Methylococcales	135618|Methylococcales	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
TH1_k127_121540_2	686340.Metal_0270	6.64e-33	128.0	COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,1SCA2@1236|Gammaproteobacteria,1XFHQ@135618|Methylococcales	135618|Methylococcales	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	-	-	-	ko:K03676	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
TH1_k127_121540_1	697282.Mettu_1261	3.713e-94	315.0	COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,1RPUQ@1236|Gammaproteobacteria,1XDJP@135618|Methylococcales	135618|Methylococcales	S	PFAM Cytochrome c assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
TH1_k127_121540_0	697282.Mettu_1304	2.801e-228	714.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1XDRQ@135618|Methylococcales	135618|Methylococcales	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
TH1_k127_121771_3	1410613.JNKF01000015_gene26	1.662e-31	133.0	COG0297@1|root,COG0438@1|root,COG0297@2|Bacteria,COG0438@2|Bacteria,4NFPA@976|Bacteroidetes,2FP8H@200643|Bacteroidia	976|Bacteroidetes	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TH1_k127_121771_0	1116472.MGMO_53c00150	1.496e-143	462.0	COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,1RN8V@1236|Gammaproteobacteria,1XEFR@135618|Methylococcales	135618|Methylococcales	K	TIGRFAM RNA polymerase sigma factor RpoS	rpoS	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TH1_k127_121771_5	547045.NEISICOT_01234	4.805e-11	64.0	COG1388@1|root,COG4942@1|root,COG1388@2|Bacteria,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,2VINR@28216|Betaproteobacteria,2KQY2@206351|Neisseriales	206351|Neisseriales	DM	Peptidase, M23 family	-	-	-	ko:K06194	-	-	-	-	ko00000	1.A.34.1.2	-	-	LysM,Peptidase_M23
TH1_k127_121771_6	1097668.BYI23_A004360	2.798e-05	48.0	COG4942@1|root,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,2VINR@28216|Betaproteobacteria,1K5Z3@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Lysin motif	nlpD	-	-	ko:K06194	-	-	-	-	ko00000	1.A.34.1.2	-	-	LysM,Peptidase_M23
TH1_k127_121771_4	1116472.MGMO_53c00170	5.995e-30	124.0	COG2214@1|root,COG2214@2|Bacteria,1PUS9@1224|Proteobacteria,1SER6@1236|Gammaproteobacteria,1XFCY@135618|Methylococcales	135618|Methylococcales	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
TH1_k127_121771_2	1116472.MGMO_53c00180	8.953e-63	220.0	COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,1S72P@1236|Gammaproteobacteria,1XF57@135618|Methylococcales	135618|Methylococcales	H	molybdopterin-guanine dinucleotide biosynthesis	mobB	-	-	ko:K03753	-	-	-	-	ko00000	-	-	-	MobB
TH1_k127_121771_1	697282.Mettu_3138	8.271e-119	391.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,1XEJX@135618|Methylococcales	135618|Methylococcales	H	MoeA N-terminal region (domain I	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
TH1_k127_1233670_0	686340.Metal_1014	1.093e-179	567.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1XDJ5@135618|Methylococcales	135618|Methylococcales	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
TH1_k127_1233670_3	697282.Mettu_1995	2.346e-108	354.0	COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,1RPVD@1236|Gammaproteobacteria,1XDQ3@135618|Methylococcales	135618|Methylococcales	C	PFAM Inorganic pyrophosphatase	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
TH1_k127_1233670_2	697282.Mettu_0309	2.158e-152	491.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,1RNN1@1236|Gammaproteobacteria,1XFZ5@135618|Methylococcales	135618|Methylococcales	S	Pfam:UPF0118	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TH1_k127_1233670_1	1116472.MGMO_50c00050	3.365e-161	524.0	COG0845@1|root,COG0845@2|Bacteria,1N97Q@1224|Proteobacteria,1TA9S@1236|Gammaproteobacteria,1XGT0@135618|Methylococcales	135618|Methylococcales	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3
TH1_k127_1246126_3	1116472.MGMO_55c00070	1.308e-110	360.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,1XE8B@135618|Methylococcales	135618|Methylococcales	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
TH1_k127_1246126_5	697282.Mettu_0180	5.449e-24	105.0	COG3113@1|root,COG3113@2|Bacteria,1NGIE@1224|Proteobacteria,1SGH6@1236|Gammaproteobacteria,1XFQI@135618|Methylococcales	135618|Methylococcales	S	STAS domain	-	-	-	ko:K07122	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	STAS_2
TH1_k127_1246126_4	1116472.MGMO_55c00050	6.408e-66	228.0	COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,1RQ0Y@1236|Gammaproteobacteria,1XEZ9@135618|Methylococcales	135618|Methylococcales	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
TH1_k127_1246126_1	857087.Metme_0700	2.752e-128	415.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1RM9H@1236|Gammaproteobacteria,1XDZ6@135618|Methylococcales	135618|Methylococcales	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
TH1_k127_1246126_2	697282.Mettu_0183	8.93e-128	416.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,1XET4@135618|Methylococcales	135618|Methylococcales	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
TH1_k127_1246126_0	686340.Metal_0240	2.923e-152	486.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,1RMT9@1236|Gammaproteobacteria,1XDSG@135618|Methylococcales	135618|Methylococcales	M	Arabinose 5-phosphate isomerase	-	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
TH1_k127_1246126_6	697282.Mettu_2985	1.593e-09	59.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1XG74@135618|Methylococcales	135618|Methylococcales	P	Cation transporter/ATPase, N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
TH1_k127_1246499_4	697282.Mettu_4121	2.502e-67	233.0	COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,1RP08@1236|Gammaproteobacteria,1XDY6@135618|Methylococcales	135618|Methylococcales	O	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide	-	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
TH1_k127_1246499_1	686340.Metal_2661	1.715e-104	346.0	COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,1S6JM@1236|Gammaproteobacteria,1XE76@135618|Methylococcales	135618|Methylococcales	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
TH1_k127_1246499_0	1116472.MGMO_115c00260	7.052e-202	636.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1XE89@135618|Methylococcales	135618|Methylococcales	F	RNA helicase	-	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
TH1_k127_1246499_5	686340.Metal_0850	6.927e-20	93.0	2AVDR@1|root,31M5E@2|Bacteria,1QJ0C@1224|Proteobacteria,1SU5E@1236|Gammaproteobacteria,1XGW8@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_1246499_3	697282.Mettu_2738	3.543e-89	297.0	COG1544@1|root,COG1544@2|Bacteria,1RJ55@1224|Proteobacteria,1S5AA@1236|Gammaproteobacteria,1XFBJ@135618|Methylococcales	135618|Methylococcales	J	Sigma 54 modulation protein / S30EA ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	Ribosomal_S30AE
TH1_k127_1246499_2	243233.MCA1006	3.76e-94	321.0	COG0204@1|root,COG1022@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1XG8Z@135618|Methylococcales	135618|Methylococcales	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,Acyltransferase,PP-binding
TH1_k127_12585_5	666685.R2APBS1_1728	1.02e-35	136.0	COG0053@1|root,COG0053@2|Bacteria,1N8A3@1224|Proteobacteria,1SDJW@1236|Gammaproteobacteria,1XB32@135614|Xanthomonadales	135614|Xanthomonadales	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_12585_4	1163617.SCD_n01815	9.554e-37	142.0	2B9KW@1|root,322Z5@2|Bacteria,1RJJB@1224|Proteobacteria,2VSVB@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_12585_1	686340.Metal_0047	2.325e-136	440.0	COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,1RMR8@1236|Gammaproteobacteria,1XF2R@135618|Methylococcales	135618|Methylococcales	P	Cation efflux family	-	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
TH1_k127_12585_0	1122165.AUHS01000012_gene2815	0.0	1550.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1JDFS@118969|Legionellales	118969|Legionellales	P	AcrB/AcrD/AcrF family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
TH1_k127_12585_3	1283300.ATXB01000001_gene777	3.254e-89	298.0	COG1230@1|root,COG1230@2|Bacteria,1MUSS@1224|Proteobacteria,1RQ3M@1236|Gammaproteobacteria,1XG51@135618|Methylococcales	135618|Methylococcales	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
TH1_k127_12585_2	1230343.CANP01000050_gene3774	2.496e-121	402.0	COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,1RPBZ@1236|Gammaproteobacteria,1JE1A@118969|Legionellales	118969|Legionellales	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	cebB	-	-	ko:K07798	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1	-	-	HlyD_D23,HlyD_D4
TH1_k127_12585_6	272624.lpg1094	1.779e-12	67.0	COG1538@1|root,COG1538@2|Bacteria,1PCPQ@1224|Proteobacteria,1RRRP@1236|Gammaproteobacteria,1JCMG@118969|Legionellales	118969|Legionellales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TH1_k127_1270919_3	663610.JQKO01000004_gene2747	7.393e-19	86.0	COG1249@1|root,COG1249@2|Bacteria,1R75Y@1224|Proteobacteria,2UPSV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.8.1.5	ko:K22364	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
TH1_k127_1270919_2	1116472.MGMO_63c00050	5.442e-76	262.0	COG1028@1|root,COG1028@2|Bacteria,1MW9A@1224|Proteobacteria,1RMMZ@1236|Gammaproteobacteria,1XG2S@135618|Methylococcales	135618|Methylococcales	IQ	PFAM short chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TH1_k127_1270919_0	1116472.MGMO_63c00060	5.749e-142	456.0	COG1788@1|root,COG1788@2|Bacteria,1NGS5@1224|Proteobacteria,1RQB6@1236|Gammaproteobacteria,1XG83@135618|Methylococcales	135618|Methylococcales	I	Coenzyme A transferase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_trans
TH1_k127_1270919_1	1116472.MGMO_63c00070	1.455e-92	306.0	COG2057@1|root,COG2057@2|Bacteria,1MY3S@1224|Proteobacteria,1SF6X@1236|Gammaproteobacteria,1XG45@135618|Methylococcales	135618|Methylococcales	I	Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_1287122_8	1116472.MGMO_89c00090	1.932e-22	96.0	COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria,1XDK2@135618|Methylococcales	135618|Methylococcales	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
TH1_k127_1287122_2	1116472.MGMO_89c00080	6.443e-135	438.0	COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,1RN2Y@1236|Gammaproteobacteria,1XEZQ@135618|Methylococcales	135618|Methylococcales	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
TH1_k127_1287122_3	697282.Mettu_3450	1.747e-116	379.0	COG3484@1|root,COG3484@2|Bacteria,1N057@1224|Proteobacteria,1RRR0@1236|Gammaproteobacteria,1XE4U@135618|Methylococcales	135618|Methylococcales	O	PFAM 20S proteasome, A and B subunits	-	-	-	ko:K07395	-	-	-	-	ko00000	-	-	-	-
TH1_k127_1287122_0	857087.Metme_3027	2.535e-174	550.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,1XDTQ@135618|Methylococcales	135618|Methylococcales	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TH1_k127_1287122_5	686340.Metal_0749	1.715e-90	305.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,1S1ZB@1236|Gammaproteobacteria,1XE78@135618|Methylococcales	135618|Methylococcales	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
TH1_k127_1287122_4	686340.Metal_0748	1.512e-91	306.0	COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,1RYD7@1236|Gammaproteobacteria,1XDNI@135618|Methylococcales	135618|Methylococcales	O	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate	ate	-	2.3.2.29	ko:K21420	-	-	R11547,R11548	RC00064	ko00000,ko01000	-	-	-	ATE_C,ATE_N
TH1_k127_1287122_1	697282.Mettu_2331	2.235e-157	512.0	COG3182@1|root,COG3182@2|Bacteria,1MXGY@1224|Proteobacteria,1RYMS@1236|Gammaproteobacteria,1XE4W@135618|Methylococcales	135618|Methylococcales	S	PepSY-associated TM region	-	-	-	-	-	-	-	-	-	-	-	-	PepSY_TM
TH1_k127_1287122_7	697282.Mettu_0907	1.158e-67	233.0	COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,1S68A@1236|Gammaproteobacteria,1XF48@135618|Methylococcales	135618|Methylococcales	I	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)	pgpA	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	-	PgpA
TH1_k127_1287122_6	686340.Metal_3484	4.536e-85	286.0	COG1409@1|root,COG1409@2|Bacteria,1R4AZ@1224|Proteobacteria,1S5VS@1236|Gammaproteobacteria,1XEX9@135618|Methylococcales	135618|Methylococcales	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
TH1_k127_1294896_16	349124.Hhal_0688	9.543e-19	91.0	2AV75@1|root,31KXS@2|Bacteria,1RKU0@1224|Proteobacteria,1S7D1@1236|Gammaproteobacteria,1WYSC@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF1640)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1640
TH1_k127_1294896_15	697282.Mettu_2915	3.524e-31	123.0	COG4226@1|root,COG4226@2|Bacteria,1N9EG@1224|Proteobacteria,1SCXG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	HicB family	-	-	-	-	-	-	-	-	-	-	-	-	HicB
TH1_k127_1294896_9	697282.Mettu_2916	1.02e-62	218.0	COG1569@1|root,COG1569@2|Bacteria,1N1T4@1224|Proteobacteria,1SE91@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	toxin-antitoxin system toxin component, PIN family	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
TH1_k127_1294896_4	857087.Metme_1565	1.921e-143	462.0	COG4260@1|root,COG4260@2|Bacteria,1MXTD@1224|Proteobacteria,1S1VS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	virion core protein (lumpy skin disease virus)	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1
TH1_k127_1294896_8	857087.Metme_1566	9.175e-71	245.0	COG3809@1|root,COG3809@2|Bacteria,1PA07@1224|Proteobacteria,1TI22@1236|Gammaproteobacteria,1XGBQ@135618|Methylococcales	135618|Methylococcales	S	Transcription factor zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-TFIIB
TH1_k127_1294896_2	697282.Mettu_2001	5.07e-224	701.0	COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,1RMMT@1236|Gammaproteobacteria,1XECR@135618|Methylococcales	135618|Methylococcales	M	Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate	mpl	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TH1_k127_1294896_13	1089439.KB902271_gene2006	8.018e-45	165.0	COG3411@1|root,COG3411@2|Bacteria,1MZR4@1224|Proteobacteria,1S8U3@1236|Gammaproteobacteria,461G4@72273|Thiotrichales	72273|Thiotrichales	C	Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	2Fe-2S_thioredx
TH1_k127_1294896_5	1116472.MGMO_136c00030	4.395e-122	394.0	COG0450@1|root,COG0450@2|Bacteria,1MX2B@1224|Proteobacteria,1RPQV@1236|Gammaproteobacteria,1XEAM@135618|Methylococcales	135618|Methylococcales	O	C-terminal domain of 1-Cys peroxiredoxin	-	-	-	-	-	-	-	-	-	-	-	-	1-cysPrx_C,AhpC-TSA
TH1_k127_1294896_12	1116472.MGMO_45c00020	1.974e-45	171.0	2EJWJ@1|root,33DM8@2|Bacteria,1NNFZ@1224|Proteobacteria,1SHVK@1236|Gammaproteobacteria,1XFJC@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_1294896_0	697282.Mettu_3067	3.393e-275	869.0	COG4262@1|root,COG4262@2|Bacteria,1QUPY@1224|Proteobacteria,1RMJV@1236|Gammaproteobacteria,1XFY9@135618|Methylococcales	135618|Methylococcales	S	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
TH1_k127_1294896_7	697282.Mettu_3066	2.063e-93	313.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1S2WI@1236|Gammaproteobacteria,1XEYK@135618|Methylococcales	135618|Methylococcales	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
TH1_k127_1294896_14	452637.Oter_3105	1.123e-37	146.0	COG2020@1|root,COG2020@2|Bacteria,46WMG@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
TH1_k127_1294896_17	522306.CAP2UW1_1124	2.783e-18	86.0	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1NR3M@1224|Proteobacteria,2VJKF@28216|Betaproteobacteria	28216|Betaproteobacteria	P	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
TH1_k127_1294896_3	697282.Mettu_0289	2.46e-192	608.0	COG2843@1|root,COG2843@2|Bacteria,1P1MG@1224|Proteobacteria,1RSI9@1236|Gammaproteobacteria,1XFZ3@135618|Methylococcales	135618|Methylococcales	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	-	-	-	-	-	-	-	-	-	PGA_cap
TH1_k127_1294896_11	686340.Metal_3165	2.015e-47	173.0	2C8BN@1|root,32RKS@2|Bacteria,1N56Z@1224|Proteobacteria,1SDJD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Glycine-zipper domain	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_OmpA
TH1_k127_1294896_1	697282.Mettu_4020	3.539e-243	757.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,1RMXH@1236|Gammaproteobacteria,1XE7S@135618|Methylococcales	135618|Methylococcales	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
TH1_k127_1294896_10	697282.Mettu_4019	8.401e-58	203.0	COG1371@1|root,COG1371@2|Bacteria,1RJU0@1224|Proteobacteria,1S8F6@1236|Gammaproteobacteria,1XFH0@135618|Methylococcales	135618|Methylococcales	S	Archease protein family (MTH1598/TM1083)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
TH1_k127_1294896_18	1111454.HMPREF1250_1977	4.08e-08	59.0	COG0736@1|root,COG0736@2|Bacteria,1VA0T@1239|Firmicutes,4H55G@909932|Negativicutes	909932|Negativicutes	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
TH1_k127_1294896_6	443143.GM18_2013	2.064e-100	347.0	COG0204@1|root,COG1022@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42NHQ@68525|delta/epsilon subdivisions,2WJZ5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase,NAD_binding_4,PP-binding,Sterile
TH1_k127_1336675_0	697282.Mettu_0889	9.565e-152	482.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,1XDTI@135618|Methylococcales	135618|Methylococcales	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TH1_k127_1336675_1	697282.Mettu_0888	1.141e-88	297.0	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,1S41P@1236|Gammaproteobacteria,1XEHW@135618|Methylococcales	135618|Methylococcales	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
TH1_k127_1336675_2	697282.Mettu_0087	2.906e-10	65.0	COG0457@1|root,COG0457@2|Bacteria,1NPG5@1224|Proteobacteria,1SIX1@1236|Gammaproteobacteria,1XF77@135618|Methylococcales	135618|Methylococcales	S	Plant specific mitochondrial import receptor subunit TOM20	-	-	-	-	-	-	-	-	-	-	-	-	TOM20_plant
TH1_k127_1391557_7	857087.Metme_0728	8.046e-25	107.0	COG2961@1|root,COG2961@2|Bacteria,1MWGA@1224|Proteobacteria,1RNI1@1236|Gammaproteobacteria,1XEQ6@135618|Methylococcales	135618|Methylococcales	J	Specifically methylates the adenine in position 2030 of 23S rRNA	rlmJ	-	2.1.1.266	ko:K07115	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RsmJ
TH1_k127_1391557_4	1116472.MGMO_26c00260	4.955e-93	308.0	COG2109@1|root,COG2109@2|Bacteria,1MUN6@1224|Proteobacteria,1RMH9@1236|Gammaproteobacteria,1XDQZ@135618|Methylococcales	135618|Methylococcales	H	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
TH1_k127_1391557_0	697282.Mettu_1412	2.277e-241	754.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1XE9U@135618|Methylococcales	135618|Methylococcales	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
TH1_k127_1391557_8	1116472.MGMO_53c00050	1.995e-18	86.0	COG2906@1|root,COG2906@2|Bacteria,1PQEY@1224|Proteobacteria,1TG7E@1236|Gammaproteobacteria,1XFV2@135618|Methylococcales	135618|Methylococcales	P	PFAM BFD-like 2Fe-2S -binding	-	-	-	ko:K02192	-	-	-	-	ko00000	-	-	-	Fer2_BFD
TH1_k127_1391557_5	1283300.ATXB01000002_gene3154	3.217e-78	263.0	COG2193@1|root,COG2193@2|Bacteria,1RCW7@1224|Proteobacteria,1S45S@1236|Gammaproteobacteria,1XF2W@135618|Methylococcales	135618|Methylococcales	P	Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
TH1_k127_1391557_1	1116472.MGMO_27c00290	7.211e-191	608.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RMGJ@1236|Gammaproteobacteria,1XDYA@135618|Methylococcales	135618|Methylococcales	Q	Flavin containing amine oxidoreductase	-	-	5.2.1.13	ko:K09835	ko00906,ko01100,ko01110,map00906,map01100,map01110	M00097	R07512	RC01960	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
TH1_k127_1391557_6	686340.Metal_3253	2.32e-52	189.0	COG3663@1|root,COG3663@2|Bacteria,1REPV@1224|Proteobacteria,1S9AV@1236|Gammaproteobacteria,1XFI6@135618|Methylococcales	135618|Methylococcales	L	Uracil DNA glycosylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	UDG
TH1_k127_1391557_2	697282.Mettu_1657	2.467e-126	412.0	COG2974@1|root,COG2974@2|Bacteria,1MXPR@1224|Proteobacteria,1RMNN@1236|Gammaproteobacteria,1XE1M@135618|Methylococcales	135618|Methylococcales	L	May be involved in recombination	rdgC	-	-	ko:K03554	-	-	-	-	ko00000,ko03400	-	-	-	RdgC
TH1_k127_1391557_3	1116472.MGMO_92c00430	1.623e-106	356.0	COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,1RMNC@1236|Gammaproteobacteria,1XE3K@135618|Methylococcales	135618|Methylococcales	M	PFAM YkuD domain	-	-	-	ko:K16291	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	YkuD
TH1_k127_1404675_1	697282.Mettu_1002	8.533e-180	575.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1XEGA@135618|Methylococcales	135618|Methylococcales	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
TH1_k127_1404675_0	686340.Metal_0524	2.126e-216	674.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,1RMZQ@1236|Gammaproteobacteria,1XDQR@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	-	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TH1_k127_1420296_2	243233.MCA1827	4.859e-39	152.0	2E3RZ@1|root,32YPK@2|Bacteria,1NJYT@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_1420296_3	765913.ThidrDRAFT_1833	4.543e-27	114.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,1WX62@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
TH1_k127_1420296_4	1547437.LL06_13815	0.000601	43.0	COG0363@1|root,COG0363@2|Bacteria,1R5K6@1224|Proteobacteria,2U77K@28211|Alphaproteobacteria,43JNP@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	6-phosphogluconolactonase	pgl	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
TH1_k127_1420296_1	1116472.MGMO_84c00070	1.146e-85	291.0	COG1192@1|root,COG1192@2|Bacteria,1R62T@1224|Proteobacteria,1S58J@1236|Gammaproteobacteria,1XG72@135618|Methylococcales	135618|Methylococcales	D	Cellulose biosynthesis protein BcsQ	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31
TH1_k127_1420296_0	697282.Mettu_0395	1.485e-188	594.0	COG5520@1|root,COG5520@2|Bacteria,1N9T9@1224|Proteobacteria,1RP92@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 30 family	-	-	3.2.1.45	ko:K01201	ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142	-	R01498	RC00059,RC00451	ko00000,ko00001,ko01000	-	GH30	-	Glyco_hydro_30,Glyco_hydro_30C
TH1_k127_1422866_8	686340.Metal_1795	5.155e-11	66.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,1RMFM@1236|Gammaproteobacteria,1XEEK@135618|Methylococcales	135618|Methylococcales	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C
TH1_k127_1422866_7	857087.Metme_0397	5.506e-30	123.0	2E80T@1|root,332F0@2|Bacteria,1N7RY@1224|Proteobacteria,1SCE8@1236|Gammaproteobacteria,1XFN9@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
TH1_k127_1422866_3	1116472.MGMO_97c00270	5.082e-124	407.0	COG5345@1|root,COG5345@2|Bacteria,1MWVH@1224|Proteobacteria,1RP5X@1236|Gammaproteobacteria,1XDRU@135618|Methylococcales	135618|Methylococcales	S	Uncharacterized protein conserved in bacteria (DUF2333)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2333
TH1_k127_1422866_1	1116472.MGMO_97c00280	5.789e-127	412.0	COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria,1XEKX@135618|Methylococcales	135618|Methylococcales	D	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TH1_k127_1422866_4	697282.Mettu_2196	6.916e-83	281.0	COG3159@1|root,COG3159@2|Bacteria,1R4BP@1224|Proteobacteria,1S953@1236|Gammaproteobacteria,1XEGU@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function, DUF484	-	-	-	ko:K09921	-	-	-	-	ko00000	-	-	-	DUF484
TH1_k127_1422866_2	697282.Mettu_2197	1.884e-126	410.0	COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,1RMGV@1236|Gammaproteobacteria,1XE5F@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
TH1_k127_1422866_0	857087.Metme_0367	2.767e-212	664.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,1RMI2@1236|Gammaproteobacteria,1XDQE@135618|Methylococcales	135618|Methylococcales	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
TH1_k127_1422866_5	697282.Mettu_2537	7.149e-79	266.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,1RPB6@1236|Gammaproteobacteria,1XF0C@135618|Methylococcales	135618|Methylococcales	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
TH1_k127_1422866_6	717774.Marme_4090	9.719e-39	157.0	COG0730@1|root,COG0730@2|Bacteria,1RBW3@1224|Proteobacteria,1S2NF@1236|Gammaproteobacteria,1XMJ1@135619|Oceanospirillales	135619|Oceanospirillales	S	Sulfite exporter TauE/SafE	-	-	-	-	-	-	-	-	-	-	-	-	TauE
TH1_k127_143199_0	857087.Metme_3823	2.673e-287	885.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1XDX0@135618|Methylococcales	135618|Methylococcales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
TH1_k127_143199_7	857087.Metme_3823	1.889e-39	149.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1XDX0@135618|Methylococcales	135618|Methylococcales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
TH1_k127_143199_6	658187.LDG_8347	7.343e-47	171.0	COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,1S5V7@1236|Gammaproteobacteria,1JEGD@118969|Legionellales	118969|Legionellales	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
TH1_k127_143199_4	243233.MCA1064	8.98e-81	271.0	COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,1S286@1236|Gammaproteobacteria,1XEHY@135618|Methylococcales	135618|Methylococcales	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
TH1_k127_143199_2	686340.Metal_3323	3.287e-123	398.0	COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,1RMDW@1236|Gammaproteobacteria,1XEX5@135618|Methylococcales	135618|Methylococcales	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
TH1_k127_143199_5	1116472.MGMO_66c00080	7.608e-75	252.0	COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,1S22R@1236|Gammaproteobacteria,1XF18@135618|Methylococcales	135618|Methylococcales	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
TH1_k127_143199_3	697282.Mettu_1346	4.298e-99	324.0	COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,1RMW0@1236|Gammaproteobacteria,1XEQN@135618|Methylococcales	135618|Methylococcales	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
TH1_k127_143199_8	697282.Mettu_1347	1.31e-33	133.0	COG0690@1|root,COG0690@2|Bacteria,1RDI9@1224|Proteobacteria,1S3PA@1236|Gammaproteobacteria,1XFB2@135618|Methylococcales	135618|Methylococcales	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
TH1_k127_143199_9	1122169.AREN01000056_gene2019	9.685e-07	50.0	COG0690@1|root,COG0690@2|Bacteria,1RDI9@1224|Proteobacteria,1S3PA@1236|Gammaproteobacteria,1JECV@118969|Legionellales	118969|Legionellales	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
TH1_k127_143199_1	2340.JV46_07390	4.147e-226	702.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,1J5DE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
TH1_k127_143464_0	686340.Metal_2127	3.046e-118	381.0	COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,1S0H0@1236|Gammaproteobacteria,1XEM1@135618|Methylococcales	135618|Methylococcales	C	Cytochrome c oxidase, subunit I	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
TH1_k127_143464_2	686340.Metal_2126	4.843e-84	281.0	COG1622@1|root,COG1622@2|Bacteria,1NZNI@1224|Proteobacteria,1S6Y2@1236|Gammaproteobacteria,1XF7A@135618|Methylococcales	135618|Methylococcales	C	Cytochrome c oxidase, subunit II	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2
TH1_k127_143464_5	857087.Metme_1609	2.258e-18	85.0	29B2J@1|root,2ZY18@2|Bacteria,1P4DG@1224|Proteobacteria,1SU52@1236|Gammaproteobacteria,1XFW5@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_143464_4	926560.KE387023_gene2058	7.746e-31	127.0	COG2020@1|root,COG2020@2|Bacteria	2|Bacteria	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
TH1_k127_143464_7	1449063.JMLS01000016_gene953	4.19e-06	49.0	2EG8N@1|root,33A0G@2|Bacteria,1VMHK@1239|Firmicutes,4HSIH@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_143464_3	697282.Mettu_2504	2.963e-36	140.0	2FJ61@1|root,34AW5@2|Bacteria,1P2US@1224|Proteobacteria,1SRD0@1236|Gammaproteobacteria,1XFN0@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_143464_6	686340.Metal_3565	1.467e-11	69.0	29974@1|root,2ZWAF@2|Bacteria,1P9UB@1224|Proteobacteria,1SV8K@1236|Gammaproteobacteria,1XFXX@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_143464_1	306281.AJLK01000091_gene3531	3.092e-88	295.0	COG0225@1|root,COG0225@2|Bacteria,1G1QF@1117|Cyanobacteria,1JJDA@1189|Stigonemataceae	1117|Cyanobacteria	O	Peptide methionine sulfoxide reductase	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
TH1_k127_143464_8	1116472.MGMO_62c00150	6.381e-05	46.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1XEDV@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
TH1_k127_1440500_0	686340.Metal_2853	5.647e-156	496.0	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,1RMKY@1236|Gammaproteobacteria,1XDRY@135618|Methylococcales	135618|Methylococcales	H	Belongs to the FPP GGPP synthase family	ispA	-	2.5.1.1,2.5.1.10	ko:K00795	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364	R01658,R02003	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
TH1_k127_1440500_2	305900.GV64_06030	1.7e-17	84.0	COG1722@1|root,COG1722@2|Bacteria,1N72V@1224|Proteobacteria,1SC7N@1236|Gammaproteobacteria,1XM23@135619|Oceanospirillales	135619|Oceanospirillales	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
TH1_k127_1440500_1	697282.Mettu_0752	2.02e-152	485.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1XES4@135618|Methylococcales	135618|Methylococcales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
TH1_k127_1444728_0	697282.Mettu_0020	5.472e-177	565.0	COG1629@1|root,COG4771@2|Bacteria,1QTS8@1224|Proteobacteria,1T1FF@1236|Gammaproteobacteria,1XDZE@135618|Methylococcales	135618|Methylococcales	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
TH1_k127_145300_3	697282.Mettu_3553	1.253e-66	232.0	COG0560@1|root,COG0560@2|Bacteria,1PIND@1224|Proteobacteria,1S9GK@1236|Gammaproteobacteria,1XEK5@135618|Methylococcales	135618|Methylococcales	E	haloacid dehalogenase-like hydrolase	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD
TH1_k127_145300_0	697282.Mettu_3554	1.593e-235	739.0	COG1052@1|root,COG1052@2|Bacteria,1REXX@1224|Proteobacteria,1T2IU@1236|Gammaproteobacteria,1XEBK@135618|Methylococcales	135618|Methylococcales	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
TH1_k127_145300_2	1116472.MGMO_44c00380	7.314e-74	252.0	COG2229@1|root,COG2229@2|Bacteria,1PYIA@1224|Proteobacteria,1S271@1236|Gammaproteobacteria,1XEEV@135618|Methylococcales	135618|Methylococcales	S	small GTP-binding protein	-	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	ATP_bind_1
TH1_k127_145300_1	686340.Metal_2927	3.346e-93	319.0	2DBSQ@1|root,2ZATE@2|Bacteria,1N58C@1224|Proteobacteria,1SAPH@1236|Gammaproteobacteria,1XFMM@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_1469157_4	314278.NB231_01878	6.725e-28	114.0	2ED2F@1|root,336ZC@2|Bacteria,1N758@1224|Proteobacteria,1SE5R@1236|Gammaproteobacteria,1X19V@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
TH1_k127_1469157_5	757424.Hsero_3426	7.56e-26	108.0	2DPYH@1|root,333YR@2|Bacteria,1NF9G@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
TH1_k127_1469157_3	768671.ThimaDRAFT_4375	9.214e-30	119.0	2E3EN@1|root,32YDN@2|Bacteria,1N7N7@1224|Proteobacteria,1SCSD@1236|Gammaproteobacteria,1WZ7T@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF4160)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4160
TH1_k127_1469157_1	857087.Metme_4595	1.013e-109	356.0	COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,1RMQW@1236|Gammaproteobacteria,1XEN2@135618|Methylococcales	135618|Methylococcales	EH	TIGRFAM glutamine amidotransferase of anthranilate synthase	trpG	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
TH1_k127_1469157_0	857087.Metme_4596	7.216e-266	824.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1XEVV@135618|Methylococcales	135618|Methylococcales	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
TH1_k127_1469157_2	857087.Metme_0188	1.69e-39	149.0	2DPP8@1|root,332V3@2|Bacteria,1NJM6@1224|Proteobacteria,1SIP1@1236|Gammaproteobacteria,1XFGW@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF3240)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3240
TH1_k127_147466_3	1123401.JHYQ01000025_gene3302	5.154e-44	164.0	COG2050@1|root,COG2050@2|Bacteria,1RH0Z@1224|Proteobacteria,1S5W6@1236|Gammaproteobacteria,461FH@72273|Thiotrichales	72273|Thiotrichales	Q	Domain of unknown function (DUF4442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4442
TH1_k127_147466_0	697282.Mettu_3311	3.77e-146	473.0	COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,1RQCV@1236|Gammaproteobacteria,1XDT6@135618|Methylococcales	135618|Methylococcales	P	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system	modC	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
TH1_k127_147466_2	697282.Mettu_3310	7.259e-96	319.0	COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,1RRDV@1236|Gammaproteobacteria,1XEMM@135618|Methylococcales	135618|Methylococcales	P	ABC transporter permease protein	modB	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
TH1_k127_147466_1	697282.Mettu_3309	2.373e-105	349.0	COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,1RN71@1236|Gammaproteobacteria,1XE8A@135618|Methylococcales	135618|Methylococcales	P	molybdenum ABC transporter, periplasmic	-	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
TH1_k127_147466_4	686340.Metal_1207	2.234e-18	85.0	COG3637@1|root,COG3637@2|Bacteria,1R64D@1224|Proteobacteria,1S325@1236|Gammaproteobacteria,1XDN4@135618|Methylococcales	135618|Methylococcales	M	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
TH1_k127_147466_5	697282.Mettu_3307	0.0002378	45.0	COG3637@1|root,COG3637@2|Bacteria,1R64D@1224|Proteobacteria,1S325@1236|Gammaproteobacteria,1XDN4@135618|Methylococcales	135618|Methylococcales	M	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
TH1_k127_1479844_2	1123392.AQWL01000008_gene1207	1.284e-54	198.0	COG3762@1|root,COG3762@2|Bacteria,1R61N@1224|Proteobacteria,2VRJE@28216|Betaproteobacteria	28216|Betaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	TPM_phosphatase
TH1_k127_1479844_0	686340.Metal_1951	2.754e-115	378.0	COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,1S38U@1236|Gammaproteobacteria,1XEUX@135618|Methylococcales	135618|Methylococcales	S	TPM domain	-	-	-	-	-	-	-	-	-	-	-	-	TPM_phosphatase
TH1_k127_1479844_1	686340.Metal_1950	7.956e-105	342.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,1RS3E@1236|Gammaproteobacteria,1XEQT@135618|Methylococcales	135618|Methylococcales	S	LemA family	-	-	-	-	-	-	-	-	-	-	-	-	LemA
TH1_k127_1487472_4	1267005.KB911262_gene3291	1.036e-05	48.0	COG2370@1|root,COG2370@2|Bacteria,1N08F@1224|Proteobacteria,2UA0Y@28211|Alphaproteobacteria,3N71A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	HupE / UreJ protein	hupE	-	-	ko:K03192	-	-	-	-	ko00000	-	-	-	HupE_UreJ
TH1_k127_1487472_0	686340.Metal_0075	1.003e-208	667.0	COG5309@1|root,COG5309@2|Bacteria,1MWJJ@1224|Proteobacteria,1SJUJ@1236|Gammaproteobacteria,1XEPP@135618|Methylococcales	135618|Methylococcales	G	Glycosyl hydrolases family 17	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_17
TH1_k127_1487472_2	697282.Mettu_2511	1.95e-51	185.0	COG3791@1|root,COG3791@2|Bacteria,1REMP@1224|Proteobacteria,1T0A3@1236|Gammaproteobacteria,1XFF8@135618|Methylococcales	135618|Methylococcales	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
TH1_k127_1487472_1	697282.Mettu_3583	7.687e-125	411.0	COG0741@1|root,COG0741@2|Bacteria,1Q8YR@1224|Proteobacteria,1THJC@1236|Gammaproteobacteria,1XEHA@135618|Methylococcales	135618|Methylococcales	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
TH1_k127_1487472_3	686340.Metal_2129	1.351e-27	112.0	COG1359@1|root,COG1359@2|Bacteria,1RI7W@1224|Proteobacteria,1TKPU@1236|Gammaproteobacteria,1XGHN@135618|Methylococcales	135618|Methylococcales	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
TH1_k127_1497439_2	697282.Mettu_2127	1.731e-56	201.0	COG1959@1|root,COG1959@2|Bacteria,1N05H@1224|Proteobacteria,1S8SJ@1236|Gammaproteobacteria,1XF8I@135618|Methylococcales	135618|Methylococcales	K	Transcriptional regulator	-	-	-	ko:K13771	ko05132,map05132	-	-	-	ko00000,ko00001,ko03000	-	-	-	Rrf2
TH1_k127_1497439_3	296591.Bpro_1180	3.107e-53	202.0	COG3391@1|root,COG3391@2|Bacteria,1QUVX@1224|Proteobacteria,2VITD@28216|Betaproteobacteria,4ABYR@80864|Comamonadaceae	28216|Betaproteobacteria	S	Alkaline phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD,VPEP
TH1_k127_1497439_0	697282.Mettu_3978	0.0	1495.0	COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,1RP5H@1236|Gammaproteobacteria,1XE4N@135618|Methylococcales	135618|Methylococcales	P	PFAM Major Facilitator Superfamily	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
TH1_k127_1497439_1	111781.Lepto7376_1993	4.913e-69	241.0	2DCT2@1|root,32U08@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PRiA4_ORF3
TH1_k127_1497439_4	697282.Mettu_3977	1.398e-33	129.0	COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,1RQ27@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	narG	-	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Molybdopterin,Molydop_binding,Nitr_red_alph_N
TH1_k127_1510868_7	1123401.JHYQ01000025_gene3302	4.994e-16	79.0	COG2050@1|root,COG2050@2|Bacteria,1RH0Z@1224|Proteobacteria,1S5W6@1236|Gammaproteobacteria,461FH@72273|Thiotrichales	72273|Thiotrichales	Q	Domain of unknown function (DUF4442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4442
TH1_k127_1510868_0	697282.Mettu_1608	0.0	1299.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RMA7@1236|Gammaproteobacteria,1XEE4@135618|Methylococcales	135618|Methylococcales	E	Domain of unknown function (DUF3458_C) ARM repeats	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,Peptidase_M1
TH1_k127_1510868_6	697282.Mettu_1607	6.698e-43	161.0	COG2363@1|root,COG2363@2|Bacteria,1MZX3@1224|Proteobacteria,1SCNB@1236|Gammaproteobacteria,1XFGA@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF423)	-	-	-	-	-	-	-	-	-	-	-	-	DUF423
TH1_k127_1510868_5	686340.Metal_1190	2.067e-86	287.0	COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,1S21E@1236|Gammaproteobacteria,1XEKU@135618|Methylococcales	135618|Methylococcales	H	May be involved in the biosynthesis of molybdopterin	moaB	-	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
TH1_k127_1510868_3	686340.Metal_1191	5.715e-200	633.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1XE18@135618|Methylococcales	135618|Methylococcales	O	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
TH1_k127_1510868_4	857087.Metme_1267	3.379e-181	570.0	COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,1RPTA@1236|Gammaproteobacteria,1XE9Q@135618|Methylococcales	135618|Methylococcales	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase
TH1_k127_1510868_2	857087.Metme_1268	1.24e-203	640.0	COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,1RMX0@1236|Gammaproteobacteria,1XEJF@135618|Methylococcales	135618|Methylococcales	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	-	ko:K02474	ko00520,map00520	-	R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
TH1_k127_1510868_1	697282.Mettu_2189	2.163e-234	730.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,1RMVW@1236|Gammaproteobacteria,1XE5W@135618|Methylococcales	135618|Methylococcales	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
TH1_k127_1515978_0	686340.Metal_3962	1.367e-247	771.0	COG0362@1|root,COG0362@2|Bacteria,1MVV8@1224|Proteobacteria,1RM7P@1236|Gammaproteobacteria,1XDUV@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
TH1_k127_1515978_1	395493.BegalDRAFT_0528	1.587e-224	717.0	COG4953@1|root,COG4953@2|Bacteria,1MUA9@1224|Proteobacteria,1RMBV@1236|Gammaproteobacteria,463Q4@72273|Thiotrichales	72273|Thiotrichales	M	Penicillin-Binding Protein C-terminus Family	-	-	-	-	-	-	-	-	-	-	-	-	BiPBP_C,Transgly,Transpeptidase
TH1_k127_1515978_2	697282.Mettu_0053	2.028e-34	141.0	COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,1SCZX@1236|Gammaproteobacteria,1XFHW@135618|Methylococcales	135618|Methylococcales	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
TH1_k127_1517021_1	686340.Metal_2389	2.709e-88	298.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,1RQ4N@1236|Gammaproteobacteria,1XEUP@135618|Methylococcales	135618|Methylococcales	Q	PFAM Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2,Cu-oxidase_3
TH1_k127_1517021_0	1173020.Cha6605_2847	0.0	1119.0	COG0021@1|root,COG0021@2|Bacteria,1G0B5@1117|Cyanobacteria	1117|Cyanobacteria	G	Belongs to the transketolase family	-	-	-	-	-	-	-	-	-	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
TH1_k127_1517021_2	1283300.ATXB01000002_gene2854	2.878e-48	178.0	COG0304@1|root,COG0304@2|Bacteria,1N91E@1224|Proteobacteria,1RMPP@1236|Gammaproteobacteria,1XDS2@135618|Methylococcales	135618|Methylococcales	IQ	Belongs to the beta-ketoacyl-ACP synthases family	-	-	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TH1_k127_15211_1	697282.Mettu_0389	3.948e-92	306.0	COG2236@1|root,COG2236@2|Bacteria,1RKB0@1224|Proteobacteria,1S7J1@1236|Gammaproteobacteria,1XFMX@135618|Methylococcales	135618|Methylococcales	F	Phosphoribosyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
TH1_k127_15211_0	243233.MCA0129	3.248e-135	439.0	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,1XEB2@135618|Methylococcales	135618|Methylococcales	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
TH1_k127_15211_2	686340.Metal_3494	2.594e-48	179.0	2CESE@1|root,32S0D@2|Bacteria,1RHTD@1224|Proteobacteria,1S5QS@1236|Gammaproteobacteria,1XF62@135618|Methylococcales	135618|Methylococcales	S	Glycine-zipper domain	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_OmpA
TH1_k127_15211_3	697282.Mettu_3738	6.486e-33	138.0	2DP14@1|root,3303I@2|Bacteria,1N7JW@1224|Proteobacteria,1TNDU@1236|Gammaproteobacteria,1XGK3@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_1523203_1	697282.Mettu_3259	1.518e-97	322.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1XEUM@135618|Methylococcales	135618|Methylococcales	P	PFAM Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
TH1_k127_1523203_2	686340.Metal_2276	3.842e-59	207.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,1XF7U@135618|Methylococcales	135618|Methylococcales	K	Belongs to the P(II) protein family	-	-	-	ko:K04752	-	-	-	-	ko00000	-	-	-	P-II
TH1_k127_1523203_0	697282.Mettu_3261	4.307e-245	762.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1XE22@135618|Methylococcales	135618|Methylococcales	U	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
TH1_k127_1525666_4	697282.Mettu_0141	1.565e-46	168.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1XEW1@135618|Methylococcales	135618|Methylococcales	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
TH1_k127_1525666_0	697282.Mettu_0140	6.204e-197	619.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,1XECZ@135618|Methylococcales	135618|Methylococcales	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3
TH1_k127_1525666_1	1116472.MGMO_15c00560	1.04e-66	229.0	COG2703@1|root,COG2703@2|Bacteria,1RK9A@1224|Proteobacteria,1SAZP@1236|Gammaproteobacteria,1XF5U@135618|Methylococcales	135618|Methylococcales	P	Hemerythrin HHE cation binding domain	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin
TH1_k127_1525666_2	686340.Metal_2959	2.147e-65	229.0	COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,1RSHS@1236|Gammaproteobacteria,1XEZ8@135618|Methylococcales	135618|Methylococcales	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	-	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
TH1_k127_1525666_3	697282.Mettu_0135	4.025e-61	217.0	COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1XF4S@135618|Methylococcales	135618|Methylococcales	H	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway	bioC	GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
TH1_k127_1545057_3	857087.Metme_2796	8.907e-08	55.0	2DKUH@1|root,30CV1@2|Bacteria,1NCRM@1224|Proteobacteria,1SC7Y@1236|Gammaproteobacteria,1XF8Z@135618|Methylococcales	135618|Methylococcales	S	PFAM General secretion pathway protein M	-	-	-	ko:K02462	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSM_b
TH1_k127_1545057_1	1116472.MGMO_61c00280	2.89e-15	85.0	2C8JT@1|root,31A2G@2|Bacteria,1RKRE@1224|Proteobacteria,1SI91@1236|Gammaproteobacteria,1XFEQ@135618|Methylococcales	135618|Methylococcales	S	general secretion pathway protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_1545057_0	686340.Metal_3828	2.12e-151	510.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,1XEQ0@135618|Methylococcales	135618|Methylococcales	NU	type II III secretion system	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
TH1_k127_1545057_2	1225184.ALXE01000068_gene289	1.704e-13	74.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,3VY9E@53335|Pantoea	1236|Gammaproteobacteria	E	Peptidase family M3	prlC	GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006465,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0034645,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051604,GO:0070011,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901576	3.4.24.70	ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
TH1_k127_155169_2	640081.Dsui_2517	2.147e-107	358.0	COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,2VP05@28216|Betaproteobacteria	28216|Betaproteobacteria	L	transposase IS116 IS110 IS902 family protein	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
TH1_k127_155169_0	857087.Metme_0873	0.0	1358.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,1XEQR@135618|Methylococcales	135618|Methylococcales	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
TH1_k127_155169_6	1108045.GORHZ_098_00160	2.923e-51	191.0	COG0596@1|root,COG0596@2|Bacteria,2I7GQ@201174|Actinobacteria	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TH1_k127_155169_3	697282.Mettu_0657	9.599e-77	258.0	COG3193@1|root,COG3193@2|Bacteria,1N1CR@1224|Proteobacteria,1SAFB@1236|Gammaproteobacteria,1XGXU@135618|Methylococcales	135618|Methylococcales	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
TH1_k127_155169_4	153948.NAL212_0227	1.401e-58	211.0	COG0500@1|root,COG2226@2|Bacteria,1PE85@1224|Proteobacteria,2W92M@28216|Betaproteobacteria,373FB@32003|Nitrosomonadales	28216|Betaproteobacteria	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TH1_k127_155169_5	1348657.M622_10900	3.594e-58	209.0	COG2020@1|root,COG2020@2|Bacteria,1PPQV@1224|Proteobacteria,2VR3S@28216|Betaproteobacteria,2KYVU@206389|Rhodocyclales	206389|Rhodocyclales	O	methyltransferase activity	-	-	2.1.1.334	ko:K21310	ko00920,map00920	-	R11546	RC02653	ko00000,ko00001,ko01000	-	-	-	-
TH1_k127_155169_1	686340.Metal_4030	0.0	1255.0	COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,1RPA0@1236|Gammaproteobacteria,1XFZU@135618|Methylococcales	135618|Methylococcales	L	Helix-hairpin-helix containing domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
TH1_k127_1566551_3	697282.Mettu_2729	1.638e-51	184.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,1RMGQ@1236|Gammaproteobacteria,1XDR5@135618|Methylococcales	135618|Methylococcales	M	3-deoxy-D-manno-octulosonic acid 8-phosphate synthase	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
TH1_k127_1566551_2	56107.Cylst_2228	6.914e-53	190.0	COG4636@1|root,COG4636@2|Bacteria,1G5FE@1117|Cyanobacteria,1HQWH@1161|Nostocales	1117|Cyanobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
TH1_k127_1566551_1	857087.Metme_2549	1.202e-68	238.0	COG4636@1|root,COG4636@2|Bacteria,1N1KS@1224|Proteobacteria,1TGY7@1236|Gammaproteobacteria,1XG5C@135618|Methylococcales	135618|Methylococcales	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
TH1_k127_1566551_0	686340.Metal_1422	9.914e-308	948.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria,1XEHF@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
TH1_k127_1566551_4	697282.Mettu_0501	9.852e-16	78.0	2BH0W@1|root,32B14@2|Bacteria,1QFHE@1224|Proteobacteria,1TG0U@1236|Gammaproteobacteria,1XFF9@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_157975_2	697282.Mettu_4181	4.371e-72	248.0	COG2340@1|root,COG2340@2|Bacteria,1QIVT@1224|Proteobacteria,1TGRU@1236|Gammaproteobacteria,1XGFJ@135618|Methylococcales	135618|Methylococcales	S	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP
TH1_k127_157975_4	1117958.PE143B_0102990	4.995e-47	175.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
TH1_k127_157975_6	857087.Metme_3072	9.129e-08	55.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1XEDV@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
TH1_k127_157975_0	697282.Mettu_2135	0.0	1126.0	COG1615@1|root,COG1615@2|Bacteria,1MZ5A@1224|Proteobacteria,1RP2H@1236|Gammaproteobacteria,1XEV9@135618|Methylococcales	135618|Methylococcales	S	PFAM Uncharacterised protein family (UPF0182)	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
TH1_k127_157975_1	697282.Mettu_3866	3.487e-188	601.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,1RND6@1236|Gammaproteobacteria,1XDXT@135618|Methylococcales	135618|Methylococcales	P	PFAM Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TH1_k127_157975_3	335283.Neut_2441	3.091e-49	181.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2VH5T@28216|Betaproteobacteria,372B6@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	dppF	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TH1_k127_1580138_2	686340.Metal_3665	9.766e-93	313.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,1RMSU@1236|Gammaproteobacteria,1XDUW@135618|Methylococcales	135618|Methylococcales	H	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	-	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
TH1_k127_1580138_0	697282.Mettu_1816	1.895e-177	573.0	COG4191@1|root,COG4191@2|Bacteria,1QU7R@1224|Proteobacteria,1T1Q4@1236|Gammaproteobacteria,1XE42@135618|Methylococcales	135618|Methylococcales	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region	-	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA
TH1_k127_1580138_1	243924.LT42_17500	2.964e-115	377.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	pilR	-	-	ko:K02481,ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH1_k127_1585696_5	202952.BBLI01000004_gene396	4.195e-32	129.0	2DNQI@1|root,32YKA@2|Bacteria,1P5I3@1224|Proteobacteria,1TNEX@1236|Gammaproteobacteria,3NQFQ@468|Moraxellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_1585696_2	1116472.MGMO_47c00080	2.484e-79	273.0	COG3228@1|root,COG3228@2|Bacteria,1RAHF@1224|Proteobacteria,1RZQU@1236|Gammaproteobacteria,1XEJB@135618|Methylococcales	135618|Methylococcales	S	Belongs to the MtfA family	-	-	-	ko:K09933	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_M90
TH1_k127_1585696_3	697282.Mettu_1756	5.883e-77	263.0	COG1309@1|root,COG1309@2|Bacteria,1RA4T@1224|Proteobacteria,1RNQH@1236|Gammaproteobacteria,1XE72@135618|Methylococcales	135618|Methylococcales	K	PFAM Transcriptional regulator, TetR-like, DNA-binding, bacterial archaeal	-	-	-	ko:K16137	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_13,TetR_N
TH1_k127_1585696_4	1121451.DESAM_21635	1.368e-42	157.0	2C82G@1|root,32RK9@2|Bacteria,1MZV5@1224|Proteobacteria,42U4W@68525|delta/epsilon subdivisions,2WQ9S@28221|Deltaproteobacteria,2MCV4@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
TH1_k127_1585696_1	686340.Metal_0731	2.465e-243	757.0	COG3391@1|root,COG3391@2|Bacteria,1MXDX@1224|Proteobacteria,1S012@1236|Gammaproteobacteria,1XDJS@135618|Methylococcales	135618|Methylococcales	S	56kDa selenium binding protein (SBP56)	-	-	-	ko:K17285	-	-	-	-	ko00000,ko04147	-	-	-	SBP56
TH1_k127_1585696_0	857087.Metme_4157	2.342e-277	865.0	COG1858@1|root,COG1999@1|root,COG1858@2|Bacteria,COG1999@2|Bacteria,1MV70@1224|Proteobacteria,1RRZM@1236|Gammaproteobacteria,1XH02@135618|Methylococcales	135618|Methylococcales	C	SCO1/SenC	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG,SCO1-SenC
TH1_k127_1585696_6	686340.Metal_1549	1.346e-28	115.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1XEE1@135618|Methylococcales	135618|Methylococcales	C	TrkA-C domain	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
TH1_k127_1596256_3	697282.Mettu_3595	2.866e-167	533.0	COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,1RNGJ@1236|Gammaproteobacteria,1XEPE@135618|Methylococcales	135618|Methylococcales	L	DNA photolyase	-	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
TH1_k127_1596256_5	686340.Metal_1089	4.402e-64	224.0	COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,1S3PI@1236|Gammaproteobacteria,1XF8S@135618|Methylococcales	135618|Methylococcales	J	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide	trmL	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
TH1_k127_1596256_1	857087.Metme_0783	0.0	1407.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1XDP7@135618|Methylococcales	135618|Methylococcales	F	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
TH1_k127_1596256_0	686340.Metal_2150	0.0	1420.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1XDPU@135618|Methylococcales	135618|Methylococcales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
TH1_k127_1596256_4	857087.Metme_1304	2.67e-94	319.0	COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria,1XF71@135618|Methylococcales	135618|Methylococcales	K	transcriptional regulator, Crp	-	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
TH1_k127_1596256_2	243233.MCA2013	2.57e-238	744.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,1XDV1@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
TH1_k127_161292_0	686340.Metal_1488	3.633e-93	311.0	COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,1RMV5@1236|Gammaproteobacteria,1XEGB@135618|Methylococcales	135618|Methylococcales	E	Belongs to the acetyltransferase family. ArgA subfamily	argA	-	2.3.1.1	ko:K14682	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,Acetyltransf_1
TH1_k127_161292_2	686340.Metal_1487	7.562e-76	263.0	COG1409@1|root,COG1409@2|Bacteria,1MWKX@1224|Proteobacteria,1RPA7@1236|Gammaproteobacteria,1XEYQ@135618|Methylococcales	135618|Methylococcales	S	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	cpdA	-	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	Metallophos
TH1_k127_161292_1	697282.Mettu_0845	3.081e-91	302.0	COG0494@1|root,COG0494@2|Bacteria,1RDGJ@1224|Proteobacteria,1S3PQ@1236|Gammaproteobacteria,1XENV@135618|Methylococcales	135618|Methylococcales	L	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage	nudH	-	-	ko:K08311	ko03018,map03018	-	R10816	RC00002	ko00000,ko00001,ko01000,ko03019	-	-	-	NUDIX
TH1_k127_1648633_0	857087.Metme_0695	2.34e-204	643.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,1RMZD@1236|Gammaproteobacteria,1XDN0@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
TH1_k127_1648633_2	697282.Mettu_0178	8.892e-106	346.0	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,1RNAX@1236|Gammaproteobacteria,1XDZP@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG
TH1_k127_1648633_1	697282.Mettu_0179	5.799e-128	411.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,1XE8B@135618|Methylococcales	135618|Methylococcales	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
TH1_k127_166946_7	1523503.JPMY01000012_gene3283	2.209e-64	239.0	COG0515@1|root,COG0515@2|Bacteria,1MVEU@1224|Proteobacteria,1SYEH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K11912	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	Pkinase
TH1_k127_166946_8	1269813.ATUL01000004_gene2185	1.042e-38	155.0	COG0631@1|root,COG0631@2|Bacteria,1N72S@1224|Proteobacteria,1SBH5@1236|Gammaproteobacteria,1WZC2@135613|Chromatiales	135613|Chromatiales	T	Serine/threonine phosphatases, family 2C, catalytic domain	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
TH1_k127_166946_0	768671.ThimaDRAFT_2046	0.0	1042.0	COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,1S0W3@1236|Gammaproteobacteria,1WX5N@135613|Chromatiales	135613|Chromatiales	KL	DNA RNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N,SWIM
TH1_k127_166946_4	697282.Mettu_1533	2.046e-115	378.0	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,1RM7U@1236|Gammaproteobacteria,1XDW1@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
TH1_k127_166946_3	697282.Mettu_1534	6.159e-133	445.0	COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,1RXX4@1236|Gammaproteobacteria,1XDPW@135618|Methylococcales	135618|Methylococcales	M	LppC putative lipoprotein	-	-	-	ko:K07121	-	-	-	-	ko00000	-	-	-	LppC
TH1_k127_166946_9	1116472.MGMO_147c00070	4.173e-33	132.0	COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,1SC8A@1236|Gammaproteobacteria,1XFD7@135618|Methylococcales	135618|Methylococcales	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
TH1_k127_166946_5	857087.Metme_4556	5.578e-97	320.0	COG0279@1|root,COG0279@2|Bacteria,1NJ8X@1224|Proteobacteria,1RS1Y@1236|Gammaproteobacteria,1XF2K@135618|Methylococcales	135618|Methylococcales	G	isomerase	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
TH1_k127_166946_10	697282.Mettu_1546	6.011e-26	115.0	COG2823@1|root,COG2823@2|Bacteria,1MUZ2@1224|Proteobacteria,1RY2B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Periplasmic or secreted lipoprotein	yraP	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0032153,GO:0044462,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	BON
TH1_k127_166946_1	697282.Mettu_1547	1.222e-220	694.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1XEHZ@135618|Methylococcales	135618|Methylococcales	C	FAD linked oxidases, C-terminal domain	-	-	1.1.5.12	ko:K03777	ko00620,ko01120,map00620,map01120	-	R00704,R11591	RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
TH1_k127_166946_2	62928.azo2354	8.6e-173	548.0	COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,2VHWA@28216|Betaproteobacteria,2KUSU@206389|Rhodocyclales	206389|Rhodocyclales	P	COG0798 Arsenite efflux pump ACR3 and related permeases	arsB	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
TH1_k127_166946_6	62928.azo2353	5.732e-67	230.0	COG0394@1|root,COG0394@2|Bacteria,1REU2@1224|Proteobacteria,2VS5B@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Low molecular weight phosphatase family	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
TH1_k127_1674091_1	247634.GPB2148_2426	4.581e-173	559.0	COG1132@1|root,COG1132@2|Bacteria,1R8US@1224|Proteobacteria,1SK1D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	ABC transporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
TH1_k127_1674091_3	1396141.BATP01000056_gene3202	5.452e-73	269.0	COG0472@1|root,COG0472@2|Bacteria,46SNJ@74201|Verrucomicrobia,2IW0H@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Glycosyl transferase family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_4
TH1_k127_1674091_2	269796.Rru_A1492	2.369e-81	287.0	COG3307@1|root,COG3307@2|Bacteria,1N225@1224|Proteobacteria,2U0RV@28211|Alphaproteobacteria,2JR1A@204441|Rhodospirillales	204441|Rhodospirillales	M	O-Antigen ligase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
TH1_k127_1674091_6	1116472.MGMO_134c00160	3.781e-06	49.0	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,1S5VJ@1236|Gammaproteobacteria,1XE0R@135618|Methylococcales	135618|Methylococcales	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
TH1_k127_1674091_5	686340.Metal_3018	6.451e-25	109.0	2BSQX@1|root,32MTR@2|Bacteria,1QJU4@1224|Proteobacteria,1THVH@1236|Gammaproteobacteria,1XFU6@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_1674091_0	1116472.MGMO_63c00010	8.428e-217	681.0	COG1012@1|root,COG1012@2|Bacteria,1QUBI@1224|Proteobacteria,1T3J1@1236|Gammaproteobacteria,1XG9M@135618|Methylococcales	135618|Methylococcales	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
TH1_k127_1674091_4	1283300.ATXB01000002_gene2747	4.795e-46	167.0	COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,1RMBA@1236|Gammaproteobacteria,1XFZ4@135618|Methylococcales	135618|Methylococcales	E	Cobalamin-independent synthase, Catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Meth_synt_2
TH1_k127_1674762_4	243233.MCA0851	6.332e-37	141.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RQ2G@1236|Gammaproteobacteria,1XDIS@135618|Methylococcales	135618|Methylococcales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
TH1_k127_1674762_2	857087.Metme_1277	1.759e-119	390.0	COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,1XGRP@135618|Methylococcales	135618|Methylococcales	C	Cytochrome C oxidase subunit II, periplasmic domain	-	-	1.10.3.10	ko:K02297	ko00190,ko01100,map00190,map01100	M00417	R11335	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.5	-	-	COX2
TH1_k127_1674762_1	857087.Metme_1278	0.0	1157.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1XG7B@135618|Methylococcales	135618|Methylococcales	C	Cytochrome c oxidase subunit	-	-	1.10.3.10	ko:K02298	ko00190,ko01100,map00190,map01100	M00417	R11335	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.5	-	-	COX1
TH1_k127_1674762_3	857087.Metme_1279	1.836e-91	304.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,1RN9D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	oxidase subunit	cyoC	-	-	ko:K02299	ko00190,ko01100,map00190,map01100	M00417	-	-	ko00000,ko00001,ko00002	3.D.4.5	-	-	COX3
TH1_k127_1674762_5	857087.Metme_1280	2.35e-30	124.0	COG3125@1|root,COG3125@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	cyoD	-	-	ko:K02300	ko00190,ko01100,map00190,map01100	M00417	-	-	ko00000,ko00001,ko00002	3.D.4.5	-	-	COX4_pro
TH1_k127_1674762_6	697282.Mettu_2819	1.256e-07	55.0	2AUT7@1|root,31KG9@2|Bacteria,1QIBC@1224|Proteobacteria,1TG5J@1236|Gammaproteobacteria,1XFQS@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_1674762_0	697282.Mettu_0654	0.0	1194.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1XG7M@135618|Methylococcales	135618|Methylococcales	C	Aconitase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aconitase,Aconitase_C
TH1_k127_1691535_2	857087.Metme_1831	1.967e-41	162.0	COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1PE6F@1224|Proteobacteria,1RWQP@1236|Gammaproteobacteria,1XDNM@135618|Methylococcales	135618|Methylococcales	CEH	2 iron, 2 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
TH1_k127_1691535_0	1116472.MGMO_45c00580	6.239e-219	687.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,1XEMY@135618|Methylococcales	135618|Methylococcales	G	Belongs to the pyruvate kinase family	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
TH1_k127_1691535_1	243233.MCA2598	8.417e-192	602.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,1RMBM@1236|Gammaproteobacteria,1XE2A@135618|Methylococcales	135618|Methylococcales	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	-	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
TH1_k127_1691535_3	1116472.MGMO_144c00130	1.351e-18	86.0	COG3637@1|root,COG3637@2|Bacteria,1QQJF@1224|Proteobacteria,1THXI@1236|Gammaproteobacteria,1XFZ2@135618|Methylococcales	135618|Methylococcales	M	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
TH1_k127_1699340_1	697282.Mettu_0632	3.073e-163	524.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RNPT@1236|Gammaproteobacteria,1XEAK@135618|Methylococcales	135618|Methylococcales	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TH1_k127_1699340_0	697282.Mettu_0633	2.139e-223	698.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1XEG9@135618|Methylococcales	135618|Methylococcales	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
TH1_k127_1723013_7	686340.Metal_1512	1.774e-05	47.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1XEVB@135618|Methylococcales	135618|Methylococcales	C	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
TH1_k127_1723013_1	697282.Mettu_3723	1.307e-222	701.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1XE7J@135618|Methylococcales	135618|Methylococcales	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TH1_k127_1723013_2	697282.Mettu_3722	1.792e-187	597.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,1RPJB@1236|Gammaproteobacteria,1XERI@135618|Methylococcales	135618|Methylococcales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TH1_k127_1723013_5	686340.Metal_3840	5.705e-138	446.0	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RPMN@1236|Gammaproteobacteria,1XDRH@135618|Methylococcales	135618|Methylococcales	M	TIGRFAM lipopolysaccharide heptosyltransferase I	-	-	-	ko:K02841	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
TH1_k127_1723013_4	697282.Mettu_1907	2.351e-148	475.0	COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,1RMBF@1236|Gammaproteobacteria,1XEXK@135618|Methylococcales	135618|Methylococcales	M	TIGRFAM Lipopolysaccharide heptosyltransferase II	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
TH1_k127_1723013_3	1116472.MGMO_61c00400	1.982e-177	559.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,1RP6Z@1236|Gammaproteobacteria,1XEIE@135618|Methylococcales	135618|Methylococcales	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
TH1_k127_1723013_0	697282.Mettu_1909	0.0	1146.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1XE97@135618|Methylococcales	135618|Methylococcales	OT	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0070566,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
TH1_k127_1723013_6	697282.Mettu_1926	1.379e-37	149.0	COG0457@1|root,COG0457@2|Bacteria,1MXK4@1224|Proteobacteria,1RNFM@1236|Gammaproteobacteria,1XEJY@135618|Methylococcales	135618|Methylococcales	S	Oxygen tolerance	-	-	-	-	-	-	-	-	-	-	-	-	BatD
TH1_k127_173643_4	686340.Metal_2554	1.768e-50	183.0	COG4244@1|root,COG4244@2|Bacteria,1NB74@1224|Proteobacteria,1SI9C@1236|Gammaproteobacteria,1XF4F@135618|Methylococcales	135618|Methylococcales	S	Predicted membrane protein (DUF2231)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231
TH1_k127_173643_0	1116472.MGMO_53c00510	2.605e-249	771.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,1SX3B@1236|Gammaproteobacteria,1XDZ9@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K00895,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
TH1_k127_173643_6	1198232.CYCME_1019	5.451e-26	115.0	2BW9S@1|root,32Z6F@2|Bacteria,1N7ID@1224|Proteobacteria,1SDWS@1236|Gammaproteobacteria,4616I@72273|Thiotrichales	72273|Thiotrichales	S	Protein of unknown function (DUF2818)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2818
TH1_k127_173643_3	1163408.UU9_04964	2.42e-63	226.0	COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,1RMGB@1236|Gammaproteobacteria,1X4AQ@135614|Xanthomonadales	135614|Xanthomonadales	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
TH1_k127_173643_1	1198232.CYCME_0023	7.158e-178	561.0	COG0301@1|root,COG0301@2|Bacteria,1N1R1@1224|Proteobacteria,1T212@1236|Gammaproteobacteria,45ZU6@72273|Thiotrichales	72273|Thiotrichales	H	Thiamine biosynthesis protein (ThiI)	-	-	-	-	-	-	-	-	-	-	-	-	ThiI
TH1_k127_173643_5	1116472.MGMO_122c00200	9.554e-32	127.0	COG0425@1|root,COG0425@2|Bacteria,1QIAC@1224|Proteobacteria,1TG4H@1236|Gammaproteobacteria,1XFM0@135618|Methylococcales	135618|Methylococcales	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	TusA
TH1_k127_173643_2	697282.Mettu_0077	2.513e-70	243.0	COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,1RNVF@1236|Gammaproteobacteria,1XDKE@135618|Methylococcales	135618|Methylococcales	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
TH1_k127_173802_1	202952.BBLI01000008_gene828	1.583e-08	59.0	2DTNT@1|root,33M3P@2|Bacteria,1NH3S@1224|Proteobacteria,1SGZB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_173802_0	1049564.TevJSym_av00170	1.39e-179	571.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,1RN3R@1236|Gammaproteobacteria,1J547@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	GO:0003674,GO:0003824,GO:0004812,GO:0004818,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006424,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	iEC042_1314.EC042_2616	tRNA-synt_1c
TH1_k127_1740266_1	1116472.MGMO_34c00280	3.005e-148	479.0	COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria,1XEBF@135618|Methylococcales	135618|Methylococcales	MU	TIGRFAM type I secretion outer membrane protein, TolC	-	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
TH1_k127_1740266_2	1397528.Q671_05530	5.539e-38	146.0	COG3492@1|root,COG3492@2|Bacteria,1MZ3I@1224|Proteobacteria,1S8SI@1236|Gammaproteobacteria,1XKGU@135619|Oceanospirillales	135619|Oceanospirillales	S	deoxycytidine triphosphate deaminase	-	-	-	ko:K09948	-	-	-	-	ko00000	-	-	-	DUF1244
TH1_k127_1740266_0	697282.Mettu_4066	9.728e-187	588.0	COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,1RMAF@1236|Gammaproteobacteria,1XEMD@135618|Methylococcales	135618|Methylococcales	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	-	-	-	-	-	-	-	-	-	-	-	FGGY_C,FGGY_N
TH1_k127_1745655_0	857087.Metme_3774	5.786e-160	507.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RMGJ@1236|Gammaproteobacteria,1XES5@135618|Methylococcales	135618|Methylococcales	H	HI0933-like protein	-	-	1.14.99.44	ko:K10210	ko00906,map00906	-	R07654,R09671,R09727,R09728	RC00254,RC02089,RC02626,RC02638	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
TH1_k127_1745655_2	686340.Metal_2464	2.213e-39	151.0	2C7YM@1|root,32RK3@2|Bacteria,1N2IQ@1224|Proteobacteria,1SDXB@1236|Gammaproteobacteria,1XFBF@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_1745655_1	1116472.MGMO_5c00020	6.209e-59	208.0	COG3439@1|root,COG3439@2|Bacteria,1NFEI@1224|Proteobacteria,1SCZP@1236|Gammaproteobacteria,1XFC2@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
TH1_k127_1745655_3	697282.Mettu_1224	3.888e-29	119.0	COG0746@1|root,COG0746@2|Bacteria,1RH3M@1224|Proteobacteria,1S74N@1236|Gammaproteobacteria,1XF53@135618|Methylococcales	135618|Methylococcales	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
TH1_k127_1795614_0	338966.Ppro_1918	1.057e-139	447.0	COG0577@1|root,COG0577@2|Bacteria,1MVSU@1224|Proteobacteria,42NKX@68525|delta/epsilon subdivisions,2WMAW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TH1_k127_1795614_1	426114.THI_1408	1.503e-126	410.0	COG1136@1|root,COG1136@2|Bacteria,1MXVW@1224|Proteobacteria,2VI95@28216|Betaproteobacteria,1KN1H@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TH1_k127_1795614_3	1163617.SCD_n01445	2.194e-56	203.0	COG3909@1|root,COG3909@2|Bacteria,1N1X2@1224|Proteobacteria,2WFRJ@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome C'	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_2
TH1_k127_1795614_6	228410.NE1347	1.324e-05	51.0	COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,2VNA0@28216|Betaproteobacteria,372UZ@32003|Nitrosomonadales	28216|Betaproteobacteria	L	InterPro IPR001584 COGs COG2801	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,rve
TH1_k127_1795614_4	1443111.JASG01000004_gene569	1.405e-55	207.0	COG0412@1|root,COG1167@1|root,COG0412@2|Bacteria,COG1167@2|Bacteria	2|Bacteria	K	transaminase activity	msi124	-	3.1.1.45	ko:K00375,ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000,ko03000	-	-	-	Aminotran_1_2,DLH,GntR
TH1_k127_1795614_2	497964.CfE428DRAFT_5382	2.064e-80	282.0	COG3919@1|root,COG3919@2|Bacteria,46WM3@74201|Verrucomicrobia	74201|Verrucomicrobia	S	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_1812284_1	697282.Mettu_4049	6.817e-109	363.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,1RQR7@1236|Gammaproteobacteria,1XED4@135618|Methylococcales	135618|Methylococcales	S	Putative peptidoglycan binding domain	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
TH1_k127_1812284_4	686340.Metal_1803	2.064e-25	109.0	COG2913@1|root,COG2913@2|Bacteria,1N44J@1224|Proteobacteria,1SSX3@1236|Gammaproteobacteria,1XFT2@135618|Methylococcales	135618|Methylococcales	J	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_1812284_3	697282.Mettu_1510	5.792e-45	172.0	COG0680@1|root,COG0680@2|Bacteria,1MZE1@1224|Proteobacteria,1SB0K@1236|Gammaproteobacteria,1XFA1@135618|Methylococcales	135618|Methylococcales	C	hydrogenase maturation protease	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_1812284_0	697282.Mettu_1511	2.666e-290	895.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,1T20U@1236|Gammaproteobacteria,1XDSA@135618|Methylococcales	135618|Methylococcales	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	-	-	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
TH1_k127_1812284_2	1116472.MGMO_20c00320	1.262e-81	284.0	COG4258@1|root,COG4258@2|Bacteria,1MU1E@1224|Proteobacteria,1RMP8@1236|Gammaproteobacteria,1XDQA@135618|Methylococcales	135618|Methylococcales	S	exporter	-	-	-	-	-	-	-	-	-	-	-	-	MMPL
TH1_k127_183052_0	1116472.MGMO_24c00030	2.112e-177	561.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1XEST@135618|Methylococcales	135618|Methylococcales	C	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for	hppA	-	3.6.1.1	ko:K01507,ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
TH1_k127_183052_1	697282.Mettu_0342	1.073e-79	271.0	COG2895@1|root,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,1RME4@1236|Gammaproteobacteria,1XDTV@135618|Methylococcales	135618|Methylococcales	H	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	cysN	-	2.7.1.25,2.7.7.4	ko:K00955	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_EFTU
TH1_k127_1840981_3	1380393.JHVP01000004_gene404	2.623e-07	60.0	COG4803@1|root,COG4803@2|Bacteria,2IIN1@201174|Actinobacteria,4EVJ5@85013|Frankiales	201174|Actinobacteria	S	membrane protein of uknown function UCP014873	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_1840981_1	1397527.Q670_10440	7.854e-237	738.0	COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,1RPUP@1236|Gammaproteobacteria,1XIGG@135619|Oceanospirillales	135619|Oceanospirillales	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components	nrtC	-	-	ko:K15576	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16.1,3.A.1.16.2	-	-	NMT1_2
TH1_k127_1840981_2	697282.Mettu_1166	7.52e-179	564.0	COG0600@1|root,COG0600@2|Bacteria,1MU6Q@1224|Proteobacteria,1RPP1@1236|Gammaproteobacteria,1XE8H@135618|Methylococcales	135618|Methylococcales	P	PFAM Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K15577	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16.1,3.A.1.16.2	-	-	BPD_transp_1
TH1_k127_1840981_0	686340.Metal_2695	0.0	999.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,1RNEH@1236|Gammaproteobacteria,1XEX0@135618|Methylococcales	135618|Methylococcales	P	TIGRFAM Nitrate transport ATP-binding	-	-	-	ko:K15578	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16.1	-	-	ABC_tran
TH1_k127_1840981_4	857087.Metme_3420	5.261e-06	52.0	2C3QV@1|root,2Z7YP@2|Bacteria,1MXAM@1224|Proteobacteria,1RNIA@1236|Gammaproteobacteria,1XEFQ@135618|Methylococcales	135618|Methylococcales	S	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
TH1_k127_189464_0	1283300.ATXB01000001_gene1875	1.485e-248	785.0	COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,1RYBQ@1236|Gammaproteobacteria,1XF30@135618|Methylococcales	135618|Methylococcales	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
TH1_k127_189464_2	686340.Metal_2568	1.281e-37	149.0	COG2197@1|root,COG2197@2|Bacteria,1N8MU@1224|Proteobacteria,1RX1I@1236|Gammaproteobacteria,1XGGG@135618|Methylococcales	135618|Methylococcales	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TH1_k127_189464_1	686340.Metal_2567	4.117e-73	248.0	COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,1RNK4@1236|Gammaproteobacteria,1XGIM@135618|Methylococcales	135618|Methylococcales	M	TIGRFAM type I secretion membrane fusion protein, HlyD	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3
TH1_k127_1953289_3	1454004.AW11_01859	2.945e-22	96.0	COG4913@1|root,COG4913@2|Bacteria,1N16Z@1224|Proteobacteria,2VJD2@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Putative exonuclease SbcCD, C subunit	-	-	-	-	-	-	-	-	-	-	-	-	AAA_29,SbcCD_C
TH1_k127_1953289_1	522306.CAP2UW1_3222	1.573e-188	597.0	COG4924@1|root,COG4924@2|Bacteria,1P11B@1224|Proteobacteria,2VKST@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Uncharacterized protein conserved in bacteria N-term (DUF3322)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2220,DUF3322
TH1_k127_1953289_0	686340.Metal_2130	2.96e-221	689.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,1T9DW@1236|Gammaproteobacteria,1XG6V@135618|Methylococcales	135618|Methylococcales	C	Iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
TH1_k127_1953289_2	686340.Metal_2129	1.129e-44	162.0	COG1359@1|root,COG1359@2|Bacteria,1RI7W@1224|Proteobacteria,1TKPU@1236|Gammaproteobacteria,1XGHN@135618|Methylococcales	135618|Methylococcales	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
TH1_k127_2030142_11	697282.Mettu_1600	2.349e-80	274.0	COG0810@1|root,COG0810@2|Bacteria,1MUMT@1224|Proteobacteria,1S3A6@1236|Gammaproteobacteria,1XDIM@135618|Methylococcales	135618|Methylococcales	M	TonB C terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
TH1_k127_2030142_12	686340.Metal_1197	7.113e-77	261.0	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,1S3YV@1236|Gammaproteobacteria,1XEAF@135618|Methylococcales	135618|Methylococcales	K	Belongs to the UPF0301 (AlgH) family	-	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
TH1_k127_2030142_14	697282.Mettu_1598	5.257e-63	219.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,1S96Q@1236|Gammaproteobacteria,1XF42@135618|Methylococcales	135618|Methylococcales	J	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
TH1_k127_2030142_10	697282.Mettu_1597	9.47e-81	272.0	COG2065@1|root,COG2065@2|Bacteria,1RI6U@1224|Proteobacteria,1S6WA@1236|Gammaproteobacteria,1XF50@135618|Methylococcales	135618|Methylococcales	F	Phosphoribosyl transferase domain	-	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
TH1_k127_2030142_3	697282.Mettu_1596	1.635e-163	520.0	COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,1RPSV@1236|Gammaproteobacteria,1XE5I@135618|Methylococcales	135618|Methylococcales	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
TH1_k127_2030142_2	686340.Metal_1201	2.535e-183	584.0	COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,1T03U@1236|Gammaproteobacteria,1XERM@135618|Methylococcales	135618|Methylococcales	F	TIGRFAM dihydroorotase, multifunctional complex type	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
TH1_k127_2030142_18	857087.Metme_1357	2.414e-14	75.0	COG2879@1|root,COG2879@2|Bacteria,1PJJ4@1224|Proteobacteria,1SW5W@1236|Gammaproteobacteria,1XFXC@135618|Methylococcales	135618|Methylococcales	S	Selenoprotein, putative	-	-	-	-	-	-	-	-	-	-	-	-	Sel_put
TH1_k127_2030142_8	697282.Mettu_0647	5.295e-115	376.0	COG1985@1|root,COG1985@2|Bacteria,1RDMT@1224|Proteobacteria,1S4SQ@1236|Gammaproteobacteria,1XDKN@135618|Methylococcales	135618|Methylococcales	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TH1_k127_2030142_16	697282.Mettu_0659	2.987e-25	106.0	2E7PS@1|root,3325B@2|Bacteria,1QNSP@1224|Proteobacteria,1SI7D@1236|Gammaproteobacteria,1XFUH@135618|Methylococcales	135618|Methylococcales	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_2030142_4	697282.Mettu_2439	9.744e-163	521.0	COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,1RMRG@1236|Gammaproteobacteria,1XEHQ@135618|Methylococcales	135618|Methylococcales	H	HemY protein N-terminus	-	-	-	ko:K02498	-	-	-	-	ko00000	-	-	-	HemY_N,TPR_8
TH1_k127_2030142_7	697282.Mettu_2438	5.414e-129	424.0	COG2959@1|root,COG2959@2|Bacteria,1MY3A@1224|Proteobacteria,1RV2A@1236|Gammaproteobacteria,1XE6W@135618|Methylococcales	135618|Methylococcales	H	HemX, putative uroporphyrinogen-III C-methyltransferase	-	-	2.1.1.107,4.2.1.75	ko:K02496,ko:K13543	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HemX
TH1_k127_2030142_13	697282.Mettu_2437	2.224e-64	230.0	COG1587@1|root,COG1587@2|Bacteria,1MWZD@1224|Proteobacteria,1RM9K@1236|Gammaproteobacteria,1XEZI@135618|Methylococcales	135618|Methylococcales	H	Uroporphyrinogen-III synthase HemD	-	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
TH1_k127_2030142_6	697282.Mettu_2436	2.17e-138	445.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria,1XDQQ@135618|Methylococcales	135618|Methylococcales	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
TH1_k127_2030142_0	697282.Mettu_2435	1.867e-225	707.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,1RMA3@1236|Gammaproteobacteria,1XDUG@135618|Methylococcales	135618|Methylococcales	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
TH1_k127_2030142_15	686340.Metal_0757	7.078e-47	173.0	COG3160@1|root,COG3160@2|Bacteria,1QK4V@1224|Proteobacteria,1TI7Z@1236|Gammaproteobacteria,1XGQV@135618|Methylococcales	135618|Methylococcales	K	Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ	-	-	-	-	-	-	-	-	-	-	-	-	Rsd_AlgQ
TH1_k127_2030142_5	697282.Mettu_0484	7.793e-140	449.0	COG2171@1|root,COG2171@2|Bacteria,1MU0Y@1224|Proteobacteria,1RPCS@1236|Gammaproteobacteria,1XECK@135618|Methylococcales	135618|Methylococcales	E	Belongs to the transferase hexapeptide repeat family	dapD	-	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,THDPS_N_2
TH1_k127_2030142_1	857087.Metme_4093	3.428e-191	602.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RPGJ@1236|Gammaproteobacteria,1XDYG@135618|Methylococcales	135618|Methylococcales	E	Aminotransferase, class I	-	-	2.6.1.17	ko:K14267	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04475	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TH1_k127_2030142_9	697282.Mettu_0486	2.016e-106	351.0	COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,1RMZ6@1236|Gammaproteobacteria,1XEP4@135618|Methylococcales	135618|Methylococcales	M	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
TH1_k127_2030142_17	697282.Mettu_2459	4.347e-20	92.0	COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,1RMEG@1236|Gammaproteobacteria,1XDRR@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
TH1_k127_2067714_0	335543.Sfum_2052	1.075e-171	547.0	COG1055@1|root,COG1055@2|Bacteria,1MUX4@1224|Proteobacteria,42MHN@68525|delta/epsilon subdivisions,2WJU0@28221|Deltaproteobacteria,2MQNQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	PFAM Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
TH1_k127_2067714_1	1121921.KB898706_gene2431	4.514e-119	404.0	COG0668@1|root,COG0668@2|Bacteria,1N66N@1224|Proteobacteria,1RQWI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
TH1_k127_2087803_3	686340.Metal_2192	1.869e-80	274.0	COG1652@1|root,COG3753@1|root,COG1652@2|Bacteria,COG3753@2|Bacteria,1RD8K@1224|Proteobacteria,1SENI@1236|Gammaproteobacteria,1XFVA@135618|Methylococcales	135618|Methylococcales	S	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	BON,LysM
TH1_k127_2087803_2	1123400.KB904780_gene1733	3.146e-103	342.0	COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,1RMF8@1236|Gammaproteobacteria,4620H@72273|Thiotrichales	72273|Thiotrichales	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
TH1_k127_2087803_5	765911.Thivi_2180	4.941e-07	56.0	2DQK2@1|root,337DF@2|Bacteria,1ND02@1224|Proteobacteria,1SDUJ@1236|Gammaproteobacteria,1WZK2@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_2087803_1	697282.Mettu_2336	3.608e-110	370.0	COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,1S5F7@1236|Gammaproteobacteria,1XE9D@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
TH1_k127_2087803_0	697282.Mettu_2335	1.031e-148	479.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RP45@1236|Gammaproteobacteria,1XE09@135618|Methylococcales	135618|Methylococcales	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TH1_k127_2087803_4	857087.Metme_4272	8.374e-38	145.0	COG1734@1|root,COG1734@2|Bacteria,1N8K6@1224|Proteobacteria,1SCNZ@1236|Gammaproteobacteria,1XFHY@135618|Methylococcales	135618|Methylococcales	K	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
TH1_k127_2099877_3	751994.AGIG01000030_gene711	1.763e-05	53.0	COG0575@1|root,COG0575@2|Bacteria,1MWSV@1224|Proteobacteria,1RQ6M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Belongs to the CDS family	cdsA	GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_1596,iSDY_1059.SDY_0191	CTP_transf_1
TH1_k127_2099877_1	697282.Mettu_0767	2.48e-103	341.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,1RMVX@1236|Gammaproteobacteria,1XEM4@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
TH1_k127_2099877_2	697282.Mettu_0766	4.064e-82	276.0	COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,1RN75@1236|Gammaproteobacteria,1XEV5@135618|Methylococcales	135618|Methylococcales	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
TH1_k127_2099877_0	857087.Metme_1636	2.108e-108	353.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,1RMHX@1236|Gammaproteobacteria,1XDK8@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
TH1_k127_2159466_8	686340.Metal_3650	1.86e-85	284.0	COG4208@1|root,COG4208@2|Bacteria,1MV8X@1224|Proteobacteria,1RNZK@1236|Gammaproteobacteria,1XES7@135618|Methylococcales	135618|Methylococcales	P	ABC transporter permease protein	cysW	-	-	ko:K02047	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	BPD_transp_1
TH1_k127_2159466_4	686340.Metal_3649	2.078e-155	497.0	COG1118@1|root,COG1118@2|Bacteria,1QTTT@1224|Proteobacteria,1RN1B@1236|Gammaproteobacteria,1XDZZ@135618|Methylococcales	135618|Methylococcales	P	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system	cysA	-	3.6.3.25	ko:K02045	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	ABC_tran,TOBE_3
TH1_k127_2159466_7	377629.TERTU_1742	9.674e-102	345.0	COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,1RN7T@1236|Gammaproteobacteria,2PN8Q@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	cysB	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0097159,GO:1901363	-	ko:K13634	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
TH1_k127_2159466_1	1005048.CFU_2028	5.01e-221	698.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,2VIQW@28216|Betaproteobacteria,473XZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Aminotransferase class-V	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
TH1_k127_2159466_3	697282.Mettu_2275	1.644e-178	561.0	COG0664@1|root,COG2905@1|root,COG0664@2|Bacteria,COG2905@2|Bacteria,1MW6M@1224|Proteobacteria,1RYWM@1236|Gammaproteobacteria,1XDVE@135618|Methylococcales	135618|Methylococcales	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_2159466_6	1266925.JHVX01000006_gene2100	1.581e-140	455.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,2VHZF@28216|Betaproteobacteria,371TM@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Bacterial transferase hexapeptide (six repeats)	srpH	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
TH1_k127_2159466_2	697282.Mettu_2273	3.046e-180	567.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1XDN6@135618|Methylococcales	135618|Methylococcales	H	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TH1_k127_2159466_13	1423816.BACQ01000064_gene2487	4.968e-06	59.0	COG2227@1|root,COG2227@2|Bacteria,1UIIR@1239|Firmicutes,4ISJH@91061|Bacilli,3F5MJ@33958|Lactobacillaceae	91061|Bacilli	H	Protein of unknown function (DUF1698)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
TH1_k127_2159466_9	582744.Msip34_2157	1.055e-77	270.0	COG2200@1|root,COG2200@2|Bacteria,1RM23@1224|Proteobacteria,2VSFS@28216|Betaproteobacteria,2KKU9@206350|Nitrosomonadales	206350|Nitrosomonadales	T	PFAM EAL domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL
TH1_k127_2159466_10	1038869.AXAN01000005_gene5353	2.147e-17	84.0	COG3585@1|root,COG3585@2|Bacteria,1N93I@1224|Proteobacteria,2VW0W@28216|Betaproteobacteria,1K9AV@119060|Burkholderiaceae	28216|Betaproteobacteria	H	domain protein	ssuF	-	-	-	-	-	-	-	-	-	-	-	TOBE
TH1_k127_2159466_5	686340.Metal_3652	3.264e-155	496.0	COG1613@1|root,COG1613@2|Bacteria,1MUAU@1224|Proteobacteria,1RMAR@1236|Gammaproteobacteria,1XEQ2@135618|Methylococcales	135618|Methylococcales	P	PFAM Bacterial extracellular solute-binding	-	-	-	ko:K02048	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	SBP_bac_11
TH1_k127_2159466_0	1116472.MGMO_144c00130	9.907e-252	783.0	COG3637@1|root,COG3637@2|Bacteria,1QQJF@1224|Proteobacteria,1THXI@1236|Gammaproteobacteria,1XFZ2@135618|Methylococcales	135618|Methylococcales	M	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
TH1_k127_2159466_12	1123020.AUIE01000021_gene1016	1.749e-07	55.0	COG5583@1|root,COG5583@2|Bacteria,1NGI6@1224|Proteobacteria	1224|Proteobacteria	S	Small protein	HA62_30270	-	-	-	-	-	-	-	-	-	-	-	DUF2292
TH1_k127_2159466_11	765911.Thivi_1494	2.077e-11	66.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1Q7PK@1224|Proteobacteria,1RSF0@1236|Gammaproteobacteria,1WWA3@135613|Chromatiales	135613|Chromatiales	L	PFAM Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_29,HTH_33
TH1_k127_2166331_2	857087.Metme_2212	1.346e-79	271.0	2CNUX@1|root,32SHU@2|Bacteria,1REYT@1224|Proteobacteria,1S2ZX@1236|Gammaproteobacteria,1XDUI@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF2760)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2760
TH1_k127_2166331_0	697282.Mettu_3235	3.914e-315	975.0	COG0443@1|root,COG0443@2|Bacteria,1MXX7@1224|Proteobacteria,1RQ12@1236|Gammaproteobacteria,1XDZB@135618|Methylococcales	135618|Methylococcales	O	Belongs to the heat shock protein 70 family	-	-	-	-	-	-	-	-	-	-	-	-	HSP70
TH1_k127_2166331_1	857087.Metme_1482	2.907e-118	384.0	2B1X5@1|root,31UDB@2|Bacteria,1QJKP@1224|Proteobacteria,1THMA@1236|Gammaproteobacteria,1XETW@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_2166331_3	697282.Mettu_3694	1.834e-70	241.0	COG1051@1|root,COG1051@2|Bacteria,1MWNH@1224|Proteobacteria,1S56W@1236|Gammaproteobacteria,1XF4J@135618|Methylococcales	135618|Methylococcales	F	NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
TH1_k127_2166331_4	1116472.MGMO_54c00020	6.509e-32	126.0	COG3045@1|root,COG3045@2|Bacteria,1RDMP@1224|Proteobacteria,1S29X@1236|Gammaproteobacteria,1XFDY@135618|Methylococcales	135618|Methylococcales	S	PFAM CreA	-	-	-	ko:K05805	-	-	-	-	ko00000	-	-	-	CreA
TH1_k127_217099_3	290398.Csal_0798	5.126e-17	87.0	COG3187@1|root,COG3187@2|Bacteria,1N9XV@1224|Proteobacteria,1S4T0@1236|Gammaproteobacteria,1XQDA@135619|Oceanospirillales	135619|Oceanospirillales	O	META domain	-	-	-	ko:K09914	-	-	-	-	ko00000	-	-	-	META,NlpE,NlpE_C,YscW
TH1_k127_217099_1	236097.ADG881_3085	1.734e-33	134.0	COG2928@1|root,COG2928@2|Bacteria,1NF4R@1224|Proteobacteria,1SFUD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Conserved Protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
TH1_k127_217099_2	237368.SCABRO_02413	3.373e-33	144.0	29MQ2@1|root,308MT@2|Bacteria,2J179@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_217099_0	583355.Caka_2618	1.808e-61	220.0	COG3637@1|root,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_217099_4	1323663.AROI01000003_gene2248	0.0002758	45.0	2EH9Y@1|root,33B1U@2|Bacteria,1NIC9@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_2183570_5	686340.Metal_2500	1.884e-34	135.0	COG0352@1|root,COG0494@1|root,COG0352@2|Bacteria,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,1RS3S@1236|Gammaproteobacteria,1XE7F@135618|Methylococcales	135618|Methylococcales	HL	TIGRFAM Mutator MutT protein	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX_4,TMP-TENI
TH1_k127_2183570_2	686340.Metal_2503	7.532e-96	319.0	COG4582@1|root,COG4582@2|Bacteria,1MW69@1224|Proteobacteria,1RNPD@1236|Gammaproteobacteria,1XEEY@135618|Methylococcales	135618|Methylococcales	D	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity	zapD	-	-	ko:K18778	-	-	-	-	ko00000,ko03036	-	-	-	ZapD
TH1_k127_2183570_4	857087.Metme_0462	4.309e-59	211.0	COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,1S3NR@1236|Gammaproteobacteria,1XF4I@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
TH1_k127_2183570_1	857087.Metme_0461	1.579e-118	388.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,1RN90@1236|Gammaproteobacteria,1XDZI@135618|Methylococcales	135618|Methylococcales	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
TH1_k127_2183570_0	857087.Metme_0460	1.206e-190	601.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RNV0@1236|Gammaproteobacteria,1XE3Q@135618|Methylococcales	135618|Methylococcales	U	PFAM Type II secretion system F domain	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
TH1_k127_2183570_3	686340.Metal_2509	4.361e-74	251.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1XES3@135618|Methylococcales	135618|Methylococcales	NU	type IV, pilus assembly	pilB	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
TH1_k127_2231977_1	1150600.ADIARSV_3675	5.911e-87	293.0	COG2020@1|root,COG2020@2|Bacteria,4NJCI@976|Bacteroidetes,1IUCI@117747|Sphingobacteriia	976|Bacteroidetes	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
TH1_k127_2231977_0	1121957.ATVL01000008_gene4308	4.415e-113	372.0	COG0500@1|root,COG2226@2|Bacteria,4NJTP@976|Bacteroidetes,47UFD@768503|Cytophagia	976|Bacteroidetes	Q	ubiE/COQ5 methyltransferase family	cmoA	-	-	ko:K15256	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_25,Methyltransf_31
TH1_k127_2231977_2	686340.Metal_2430	7.061e-42	159.0	COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria,1MWF8@1224|Proteobacteria,1S08E@1236|Gammaproteobacteria,1XDJZ@135618|Methylococcales	135618|Methylococcales	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_17,Glyco_tranf_2_3
TH1_k127_2243431_1	583355.Caka_1352	7.427e-17	81.0	COG1574@1|root,COG1574@2|Bacteria	2|Bacteria	G	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
TH1_k127_2243431_2	550540.Fbal_2114	1.826e-11	65.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
TH1_k127_2243431_0	1366050.N234_35005	7.623e-208	655.0	COG4320@1|root,COG4320@2|Bacteria,1N6EW@1224|Proteobacteria,2VN9A@28216|Betaproteobacteria,1K2DQ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
TH1_k127_2256561_2	697282.Mettu_3058	1.051e-65	228.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S7QZ@1236|Gammaproteobacteria,1XFEK@135618|Methylococcales	135618|Methylococcales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
TH1_k127_2256561_4	697282.Mettu_3057	6.074e-12	68.0	2AVBS@1|root,31M32@2|Bacteria,1QIYB@1224|Proteobacteria,1TGV0@1236|Gammaproteobacteria,1XGRT@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF2934)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2934
TH1_k127_2256561_3	1484158.PSNIH1_06895	3.629e-56	202.0	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,1RN21@1236|Gammaproteobacteria,3VZ00@53335|Pantoea	1236|Gammaproteobacteria	L	Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle	rsmD	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052913,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
TH1_k127_2256561_1	697282.Mettu_3675	5.887e-173	552.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,1RN3E@1236|Gammaproteobacteria,1XEB0@135618|Methylococcales	135618|Methylococcales	S	PFAM Peptidase M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
TH1_k127_2256561_0	697282.Mettu_3676	7.15e-192	608.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,1XEP5@135618|Methylococcales	135618|Methylococcales	S	Belongs to the peptidase M16 family	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
TH1_k127_2258098_2	1118235.CAJH01000070_gene3670	3.63e-19	90.0	COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria	1224|Proteobacteria	M	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
TH1_k127_2258098_0	631362.Thi970DRAFT_00727	1.358e-89	312.0	COG2235@1|root,COG2235@2|Bacteria,1NCGV@1224|Proteobacteria,1RM99@1236|Gammaproteobacteria,1WZMQ@135613|Chromatiales	135613|Chromatiales	E	Arginine deiminase	arcA	-	3.5.3.6	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130	-	R00552	RC00177	ko00000,ko00001,ko01000	-	-	-	Amidinotransf
TH1_k127_2258098_1	697282.Mettu_1882	5.655e-31	127.0	COG1330@1|root,COG1330@2|Bacteria,1MWTI@1224|Proteobacteria,1RNT0@1236|Gammaproteobacteria,1XE80@135618|Methylococcales	135618|Methylococcales	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity	recC	-	3.1.11.5	ko:K03583	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_V_gamma
TH1_k127_2300672_11	1116472.MGMO_60c00220	3.844e-11	70.0	COG3073@1|root,COG3073@2|Bacteria,1QICT@1224|Proteobacteria,1SJ3Y@1236|Gammaproteobacteria,1XFUY@135618|Methylococcales	135618|Methylococcales	T	Anti sigma-E protein RseA, N-terminal domain	-	-	-	ko:K03597	-	-	-	-	ko00000,ko03021	-	-	-	RseA_N
TH1_k127_2300672_8	1116472.MGMO_60c00230	4.358e-67	241.0	COG3026@1|root,COG3026@2|Bacteria,1MUQ8@1224|Proteobacteria,1RNF3@1236|Gammaproteobacteria,1XF0F@135618|Methylococcales	135618|Methylococcales	T	MucB/RseB C-terminal domain	-	-	-	ko:K03598	-	-	-	-	ko00000,ko03021	-	-	-	MucB_RseB,MucB_RseB_C
TH1_k127_2300672_1	686340.Metal_3800	1.771e-198	629.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1XE25@135618|Methylococcales	135618|Methylococcales	M	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
TH1_k127_2300672_0	686340.Metal_1537	0.0	1040.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,1RPFB@1236|Gammaproteobacteria,1XE1C@135618|Methylococcales	135618|Methylococcales	J	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
TH1_k127_2300672_3	697282.Mettu_1137	1.319e-126	409.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,1RMHI@1236|Gammaproteobacteria,1XEDU@135618|Methylococcales	135618|Methylococcales	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
TH1_k127_2300672_10	697282.Mettu_1136	1.092e-33	133.0	COG4969@1|root,COG4969@2|Bacteria,1N71K@1224|Proteobacteria,1SCYD@1236|Gammaproteobacteria,1XFGK@135618|Methylococcales	135618|Methylococcales	NU	Domain of unknown function (DUF4845)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4845
TH1_k127_2300672_5	697282.Mettu_1135	7.003e-90	301.0	COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,1RN0C@1236|Gammaproteobacteria,1XDP0@135618|Methylococcales	135618|Methylococcales	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
TH1_k127_2300672_2	697282.Mettu_1134	4.736e-140	453.0	COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,1RN3A@1236|Gammaproteobacteria,1XE7Q@135618|Methylococcales	135618|Methylococcales	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
TH1_k127_2300672_9	243233.MCA1461	2.875e-45	173.0	COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,1RN8Y@1236|Gammaproteobacteria,1XF06@135618|Methylococcales	135618|Methylococcales	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
TH1_k127_2300672_4	697282.Mettu_1132	3.749e-113	372.0	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,1RMS5@1236|Gammaproteobacteria,1XE0P@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	-	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
TH1_k127_2300672_7	697282.Mettu_1131	1.659e-86	292.0	COG0631@1|root,COG0631@2|Bacteria,1MVE7@1224|Proteobacteria,1SZE9@1236|Gammaproteobacteria,1XDM8@135618|Methylococcales	135618|Methylococcales	T	Serine/threonine phosphatases, family 2C, catalytic domain	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
TH1_k127_2300672_6	697282.Mettu_0998	2.68e-89	300.0	COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,1RMCR@1236|Gammaproteobacteria,1XDRN@135618|Methylococcales	135618|Methylococcales	P	PFAM NnrS	-	-	-	ko:K07234	-	-	-	-	ko00000	-	-	-	NnrS
TH1_k127_2318951_3	857087.Metme_0742	2.381e-112	365.0	COG0269@1|root,COG0269@2|Bacteria,1QWE4@1224|Proteobacteria,1RRCI@1236|Gammaproteobacteria,1XEF9@135618|Methylococcales	135618|Methylococcales	G	PFAM Orotidine 5'-phosphate decarboxylase	-	-	4.1.2.43	ko:K08093	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05338	RC00421,RC00422	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
TH1_k127_2318951_4	686340.Metal_3464	3.944e-91	303.0	COG0794@1|root,COG0794@2|Bacteria,1RFKB@1224|Proteobacteria,1S5NP@1236|Gammaproteobacteria,1XEGT@135618|Methylococcales	135618|Methylococcales	M	SIS domain	-	-	5.3.1.27	ko:K08094	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05339,R09780	RC00377	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS
TH1_k127_2318951_0	857087.Metme_0743	0.0	1223.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1XE7N@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
TH1_k127_2318951_5	1116472.MGMO_45c00120	5.825e-40	157.0	2994J@1|root,2ZW81@2|Bacteria,1P4KK@1224|Proteobacteria,1ST9P@1236|Gammaproteobacteria,1XFJX@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_2318951_6	857087.Metme_0745	6.733e-12	74.0	2AW3M@1|root,31MYG@2|Bacteria,1QJQE@1224|Proteobacteria,1THRK@1236|Gammaproteobacteria,1XFG6@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_2318951_1	857087.Metme_4076	1.205e-182	574.0	COG0176@1|root,COG0176@2|Bacteria,1MWQ8@1224|Proteobacteria,1RMS0@1236|Gammaproteobacteria,1XDSV@135618|Methylococcales	135618|Methylococcales	F	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	GO:0003674,GO:0003824,GO:0004801,GO:0016740,GO:0016744	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
TH1_k127_2318951_2	686340.Metal_3459	3.428e-145	464.0	COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,1RQUC@1236|Gammaproteobacteria,1XEHE@135618|Methylococcales	135618|Methylococcales	G	fructose-bisphosphate aldolase, class II, yeast E. coli subtype	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
TH1_k127_2351735_0	1304883.KI912532_gene568	1.359e-280	871.0	COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,2VKWB@28216|Betaproteobacteria,2KVQ3@206389|Rhodocyclales	206389|Rhodocyclales	J	COG0480 Translation elongation factors (GTPases)	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
TH1_k127_2351735_1	243233.MCA1404	3.228e-186	589.0	COG0277@1|root,COG0277@2|Bacteria,1MV1Q@1224|Proteobacteria,1RSC3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	FAD binding domain	-	-	1.3.1.72	ko:K09828	ko00100,ko01100,ko01110,map00100,map01100,map01110	M00101	R01457,R03689,R05703,R07488,R07493,R07498,R07499,R07507,R11096	RC00522,RC01887,RC02419	ko00000,ko00001,ko00002,ko01000	-	-	-	ALO,Acetyltransf_1,FAD_binding_4,Methyltransf_11
TH1_k127_2363102_0	686340.Metal_2202	0.0	1041.0	COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,1XEBM@135618|Methylococcales	135618|Methylococcales	O	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
TH1_k127_2363102_2	686340.Metal_3347	1.173e-65	231.0	2DN0A@1|root,32UPR@2|Bacteria,1N1BR@1224|Proteobacteria,1S9NG@1236|Gammaproteobacteria,1XFDP@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_2363102_1	686340.Metal_3346	2.973e-277	861.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQ9@1236|Gammaproteobacteria,1XEUF@135618|Methylococcales	135618|Methylococcales	S	ABC1 family	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
TH1_k127_2363720_4	857087.Metme_4463	2.503e-11	63.0	COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,1RNYH@1236|Gammaproteobacteria,1XEIY@135618|Methylococcales	135618|Methylococcales	E	Belongs to the TrpC family	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
TH1_k127_2363720_3	522306.CAP2UW1_1474	1.33e-45	171.0	COG0560@1|root,COG0560@2|Bacteria,1RKIX@1224|Proteobacteria,2VUZB@28216|Betaproteobacteria	28216|Betaproteobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
TH1_k127_2363720_1	697282.Mettu_3599	2.445e-114	374.0	COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,1S5KU@1236|Gammaproteobacteria,1XDYF@135618|Methylococcales	135618|Methylococcales	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TH1_k127_2363720_2	706587.Desti_2056	3.684e-95	315.0	COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,42QWV@68525|delta/epsilon subdivisions,2WMPT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
TH1_k127_2363720_0	686340.Metal_3537	2.687e-189	593.0	COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,1RNFF@1236|Gammaproteobacteria,1XDSS@135618|Methylococcales	135618|Methylococcales	G	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1	fbp	-	3.1.3.11	ko:K03841	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910	M00003,M00165,M00167,M00344	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FBPase
TH1_k127_2414361_3	697282.Mettu_4346	2.556e-108	358.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,1RMPS@1236|Gammaproteobacteria,1XEGQ@135618|Methylococcales	135618|Methylococcales	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
TH1_k127_2414361_0	697282.Mettu_1734	6.978e-253	787.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1XDIR@135618|Methylococcales	135618|Methylococcales	O	Mg chelatase-related protein	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
TH1_k127_2414361_5	1116472.MGMO_112c00090	3.386e-28	116.0	COG2960@1|root,COG2960@2|Bacteria,1N7AH@1224|Proteobacteria,1SCH1@1236|Gammaproteobacteria,1XFG1@135618|Methylococcales	135618|Methylococcales	S	Membrane fusogenic activity	-	-	-	ko:K09806	-	-	-	-	ko00000	-	-	-	BMFP
TH1_k127_2414361_4	697282.Mettu_1685	2.041e-94	314.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,1RNPM@1236|Gammaproteobacteria,1XEED@135618|Methylococcales	135618|Methylococcales	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
TH1_k127_2414361_1	686340.Metal_3714	1.275e-198	622.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1XDNT@135618|Methylococcales	135618|Methylococcales	NU	TIGRFAM Pilus retraction protein PilT	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
TH1_k127_2414361_2	857087.Metme_4274	1.046e-189	597.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1XEE2@135618|Methylococcales	135618|Methylococcales	NU	TIGRFAM Pilus retraction protein PilT	-	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
TH1_k127_2429209_6	857087.Metme_0799	2.062e-29	118.0	COG3558@1|root,COG3558@2|Bacteria,1RA64@1224|Proteobacteria,1S252@1236|Gammaproteobacteria,1XF0U@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF1348)	-	-	-	ko:K09958	-	-	-	-	ko00000	-	-	-	DUF1348
TH1_k127_2429209_3	296591.Bpro_2654	1.953e-69	242.0	COG1309@1|root,COG1309@2|Bacteria,1R67Z@1224|Proteobacteria,2VR8H@28216|Betaproteobacteria,4AEQQ@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TH1_k127_2429209_4	243233.MCA1696	4.56e-35	138.0	COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,1S61C@1236|Gammaproteobacteria,1XF3E@135618|Methylococcales	135618|Methylococcales	I	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
TH1_k127_2429209_1	697282.Mettu_2883	2.088e-81	273.0	2B7YH@1|root,3215N@2|Bacteria,1RJP9@1224|Proteobacteria,1S6AA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
TH1_k127_2429209_0	472759.Nhal_3537	1.754e-147	478.0	COG0665@1|root,COG0665@2|Bacteria	2|Bacteria	E	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DAO
TH1_k127_2429209_2	56110.Oscil6304_3613	9.027e-71	272.0	COG2114@1|root,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	BLUF,CHASE2,Guanylate_cyc
TH1_k127_2429209_8	440512.C211_12756	6.69e-07	63.0	COG0664@1|root,COG0664@2|Bacteria,1RKRH@1224|Proteobacteria,1S42Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
TH1_k127_2429209_7	1121946.AUAX01000012_gene6734	1.379e-28	135.0	COG1252@1|root,COG1252@2|Bacteria,2GJFE@201174|Actinobacteria,4DBNJ@85008|Micromonosporales	201174|Actinobacteria	C	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	ndh1	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TH1_k127_2429209_5	671143.DAMO_1313	7.146e-34	152.0	2CIVS@1|root,32S8M@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_2433326_3	196490.AUEZ01000005_gene3646	1.093e-31	128.0	COG2105@1|root,COG2105@2|Bacteria,1N80E@1224|Proteobacteria,2U5YU@28211|Alphaproteobacteria,3JY9V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Gamma-glutamyl cyclotransferase, AIG2-like	-	-	-	-	-	-	-	-	-	-	-	-	GGACT
TH1_k127_2433326_0	686340.Metal_3478	2.993e-166	534.0	COG0454@1|root,COG0456@2|Bacteria,1MVZ2@1224|Proteobacteria,1RSC5@1236|Gammaproteobacteria,1XEX3@135618|Methylococcales	135618|Methylococcales	K	Peptidase_C39 like family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,DUF3335
TH1_k127_2433326_1	697282.Mettu_3087	2.808e-149	481.0	COG2866@1|root,COG2866@2|Bacteria,1N6CX@1224|Proteobacteria,1RZAW@1236|Gammaproteobacteria,1XE1U@135618|Methylococcales	135618|Methylococcales	E	Protein of unknown function (DUF2817)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2817
TH1_k127_2433326_2	697282.Mettu_3086	1.659e-116	381.0	COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,1RNXP@1236|Gammaproteobacteria,1XED7@135618|Methylococcales	135618|Methylococcales	HJ	PFAM ATP-grasp fold	-	-	-	-	-	-	-	-	-	-	-	-	RLAN,RimK
TH1_k127_2469095_3	857087.Metme_0188	1.901e-07	54.0	2DPP8@1|root,332V3@2|Bacteria,1NJM6@1224|Proteobacteria,1SIP1@1236|Gammaproteobacteria,1XFGW@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF3240)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3240
TH1_k127_2469095_0	697282.Mettu_2025	0.0	1561.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1XEBY@135618|Methylococcales	135618|Methylococcales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
TH1_k127_2469095_1	697282.Mettu_2023	2.413e-110	369.0	COG0845@1|root,COG0845@2|Bacteria,1QN99@1224|Proteobacteria,1S0F7@1236|Gammaproteobacteria,1XEEX@135618|Methylococcales	135618|Methylococcales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
TH1_k127_2469095_2	1116472.MGMO_156c00020	1.826e-11	65.0	COG1538@1|root,COG1538@2|Bacteria,1RDXS@1224|Proteobacteria,1SZYV@1236|Gammaproteobacteria,1XEDE@135618|Methylococcales	135618|Methylococcales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TH1_k127_2504132_4	697282.Mettu_1213	1.36e-09	59.0	COG3431@1|root,COG3431@2|Bacteria,1N6PE@1224|Proteobacteria,1T0WM@1236|Gammaproteobacteria,1XEZF@135618|Methylococcales	135618|Methylococcales	S	Sensors of blue-light using FAD	-	-	-	-	-	-	-	-	-	-	-	-	BLUF,PsiE
TH1_k127_2504132_0	697282.Mettu_2946	1.058e-156	506.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,1RN2U@1236|Gammaproteobacteria,1XG6Z@135618|Methylococcales	135618|Methylococcales	C	Cytochrome bd terminal oxidase subunit I	-	-	-	-	-	-	-	-	-	-	-	-	Cyt_bd_oxida_I
TH1_k127_2504132_2	1218084.BBJK01000118_gene6838	8.351e-56	206.0	COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,2W05D@28216|Betaproteobacteria,1KH5E@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Cytochrome bd terminal oxidase subunit II	-	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
TH1_k127_2504132_1	1118153.MOY_04979	1.665e-60	214.0	COG3040@1|root,COG3040@2|Bacteria,1RDAI@1224|Proteobacteria,1S3PW@1236|Gammaproteobacteria,1XK1H@135619|Oceanospirillales	135619|Oceanospirillales	M	lipocalin	-	-	-	ko:K03098	-	-	-	-	ko00000,ko04147	-	-	-	Lipocalin_2
TH1_k127_2504132_3	1536772.R70723_19995	1.66e-12	74.0	COG0584@1|root,COG0584@2|Bacteria,1TQ3Y@1239|Firmicutes,4HAI9@91061|Bacilli,26VGB@186822|Paenibacillaceae	91061|Bacilli	C	Glycerophosphoryl diester phosphodiesterase family	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
TH1_k127_2520348_0	1116472.MGMO_100c00110	2.734e-259	807.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1XDK9@135618|Methylococcales	135618|Methylococcales	L	TIGRFAM RNA helicase, ATP-dependent DEAH box, HrpA type	-	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DUF3418,HA2,Helicase_C,OB_NTP_bind
TH1_k127_2520348_3	1116472.MGMO_101c00100	3.873e-41	156.0	2C9B9@1|root,32RP0@2|Bacteria,1MZKM@1224|Proteobacteria,1S8UZ@1236|Gammaproteobacteria,1XFFN@135618|Methylococcales	135618|Methylococcales	S	PFAM HopJ type III effector protein	-	-	-	-	-	-	-	-	-	-	-	-	HopJ
TH1_k127_2520348_2	857087.Metme_1517	3.255e-116	380.0	COG0834@1|root,COG0834@2|Bacteria,1MWWZ@1224|Proteobacteria,1S2ZV@1236|Gammaproteobacteria,1XDTB@135618|Methylococcales	135618|Methylococcales	ET	ABC transporter substrate-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3
TH1_k127_2520348_1	686340.Metal_1195	8.423e-163	520.0	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,1RMU0@1236|Gammaproteobacteria,1XDKV@135618|Methylococcales	135618|Methylococcales	H	Belongs to the prokaryotic GSH synthase family	gshB	-	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
TH1_k127_2520348_4	1282356.H045_19195	1.038e-13	77.0	COG0810@1|root,COG0810@2|Bacteria,1MUMT@1224|Proteobacteria,1S3A6@1236|Gammaproteobacteria,1YPME@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	M	TonB C terminal	tonB3	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
TH1_k127_2528817_0	697282.Mettu_2996	1.26e-164	526.0	COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,1RP2A@1236|Gammaproteobacteria,1XE90@135618|Methylococcales	135618|Methylococcales	O	TIGRFAM SUF system FeS cluster assembly, SufD	sufD	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
TH1_k127_2528817_1	686340.Metal_1181	3.521e-134	430.0	COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,1RPFE@1236|Gammaproteobacteria,1XE5C@135618|Methylococcales	135618|Methylococcales	O	ATPase SufC	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
TH1_k127_2528817_2	1116472.MGMO_8c00670	1.973e-75	253.0	COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,1RQ65@1236|Gammaproteobacteria,1XEJ8@135618|Methylococcales	135618|Methylococcales	O	FeS assembly protein SufB	sufB	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
TH1_k127_2530031_9	1123242.JH636434_gene5439	4.956e-05	48.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	yjaU	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Hydrolase_4
TH1_k127_2530031_1	243233.MCA1561	2.851e-149	477.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,1XG63@135618|Methylococcales	135618|Methylococcales	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TH1_k127_2530031_2	243233.MCA1562	8.487e-131	420.0	COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,1XG0J@135618|Methylococcales	135618|Methylococcales	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
TH1_k127_2530031_0	243233.MCA1563	3.925e-267	835.0	COG3225@1|root,COG3225@2|Bacteria,1MY63@1224|Proteobacteria,1RP5E@1236|Gammaproteobacteria,1XG2H@135618|Methylococcales	135618|Methylococcales	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
TH1_k127_2530031_4	243233.MCA1564	1.128e-90	313.0	2DM5E@1|root,31SVN@2|Bacteria,1MYKR@1224|Proteobacteria,1SF2N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
TH1_k127_2530031_7	1116472.MGMO_52c00090	8.654e-09	65.0	COG0220@1|root,COG0220@2|Bacteria,1QZB6@1224|Proteobacteria,1T52W@1236|Gammaproteobacteria,1XEH1@135618|Methylococcales	135618|Methylococcales	J	tRNA (guanine-N7-)-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_2530031_3	882378.RBRH_01486	8.495e-109	360.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2VIW1@28216|Betaproteobacteria,1K0EM@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
TH1_k127_2530031_6	243233.MCA1704	2.154e-22	98.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,1XER9@135618|Methylococcales	135618|Methylococcales	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
TH1_k127_2530031_8	349124.Hhal_2340	3.778e-08	56.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,1S8YR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
TH1_k127_2530031_5	1307759.JOMJ01000003_gene1489	9.676e-69	254.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42NG3@68525|delta/epsilon subdivisions,2WJ95@28221|Deltaproteobacteria,2M84C@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
TH1_k127_2656900_4	261292.Nit79A3_2358	9.071e-24	101.0	COG0451@1|root,COG0451@2|Bacteria,1MU1A@1224|Proteobacteria,2VK3S@28216|Betaproteobacteria	28216|Betaproteobacteria	GM	Nad-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TH1_k127_2656900_1	686340.Metal_2185	3.013e-197	619.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RN3S@1236|Gammaproteobacteria,1XDRB@135618|Methylococcales	135618|Methylococcales	E	PFAM Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TH1_k127_2656900_2	697282.Mettu_1622	7.874e-142	454.0	COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,1RMXS@1236|Gammaproteobacteria,1XDWH@135618|Methylococcales	135618|Methylococcales	E	Methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
TH1_k127_2656900_0	857087.Metme_0759	7.14e-243	754.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,1RMW8@1236|Gammaproteobacteria,1XDX9@135618|Methylococcales	135618|Methylococcales	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
TH1_k127_2656900_3	1116472.MGMO_124c00080	2.057e-121	391.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,1RNV6@1236|Gammaproteobacteria,1XEHS@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
TH1_k127_269074_1	85643.Tmz1t_0049	2.736e-43	159.0	2CB46@1|root,31GHU@2|Bacteria,1NGIC@1224|Proteobacteria,2VQSQ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Domain of unknown function (DUF4194)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4194
TH1_k127_269074_0	522306.CAP2UW1_3223	0.0	1019.0	COG4913@1|root,COG4913@2|Bacteria,1N16Z@1224|Proteobacteria,2VJD2@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Putative exonuclease SbcCD, C subunit	-	-	-	-	-	-	-	-	-	-	-	-	AAA_29,SbcCD_C
TH1_k127_2714554_0	857087.Metme_0393	2.891e-238	752.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1XDSH@135618|Methylococcales	135618|Methylococcales	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
TH1_k127_2714554_3	697282.Mettu_3094	6.612e-52	187.0	COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,1S3QE@1236|Gammaproteobacteria,1XFE1@135618|Methylococcales	135618|Methylococcales	FG	Scavenger mRNA decapping enzyme C-term binding	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
TH1_k127_2714554_2	697282.Mettu_3091	1.7e-86	290.0	COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,1RN99@1236|Gammaproteobacteria,1XDW3@135618|Methylococcales	135618|Methylococcales	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
TH1_k127_2714554_1	697282.Mettu_3089	2.95e-153	496.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,1RMIA@1236|Gammaproteobacteria,1XDWV@135618|Methylococcales	135618|Methylococcales	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_5
TH1_k127_2752224_1	1380394.JADL01000002_gene1572	8.832e-45	166.0	COG0639@1|root,COG0639@2|Bacteria,1RD8M@1224|Proteobacteria,2U7N2@28211|Alphaproteobacteria,2JSBR@204441|Rhodospirillales	204441|Rhodospirillales	T	Calcineurin-like phosphoesterase	-	-	3.1.3.16	ko:K07313	-	-	-	-	ko00000,ko01000	-	-	-	Metallophos
TH1_k127_2752224_0	395493.BegalDRAFT_2277	1.209e-175	555.0	COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,1RNJD@1236|Gammaproteobacteria,46189@72273|Thiotrichales	72273|Thiotrichales	GM	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	4.1.1.35	ko:K08678	ko00520,ko01100,map00520,map01100	M00361	R01384	RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
TH1_k127_2752224_2	2340.JV46_03370	4.857e-33	135.0	COG0250@1|root,COG0250@2|Bacteria,1N01W@1224|Proteobacteria,1S91B@1236|Gammaproteobacteria,1J710@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components	rfaH	GO:0001000,GO:0001073,GO:0001121,GO:0001124,GO:0003674,GO:0003676,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008494,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031554,GO:0031564,GO:0032268,GO:0032270,GO:0032774,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045182,GO:0045727,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090079,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141	-	ko:K05785	-	-	-	-	ko00000,ko03000	-	-	-	NusG
TH1_k127_2752224_3	491952.Mar181_0471	1.198e-32	129.0	COG1846@1|root,COG1846@2|Bacteria,1N0TY@1224|Proteobacteria,1SADN@1236|Gammaproteobacteria,1XMBR@135619|Oceanospirillales	135619|Oceanospirillales	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
TH1_k127_2772730_1	243233.MCA1848	0.0	1003.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1XE3D@135618|Methylococcales	135618|Methylococcales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
TH1_k127_2772730_4	697282.Mettu_3205	1.464e-87	296.0	COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,1RN5M@1236|Gammaproteobacteria,1XEEM@135618|Methylococcales	135618|Methylococcales	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	ftsJ	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
TH1_k127_2772730_7	697282.Mettu_3206	5.233e-28	115.0	COG1534@1|root,COG1534@2|Bacteria,1N8K5@1224|Proteobacteria,1SDIM@1236|Gammaproteobacteria,1XFJU@135618|Methylococcales	135618|Methylococcales	J	CRS1_YhbY	-	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
TH1_k127_2772730_5	697282.Mettu_3207	1.263e-74	254.0	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,1S3UP@1236|Gammaproteobacteria,1XEZP@135618|Methylococcales	135618|Methylococcales	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
TH1_k127_2772730_0	857087.Metme_3296	0.0	1878.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1XE54@135618|Methylococcales	135618|Methylococcales	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
TH1_k127_2772730_6	232348.ADXL01000091_gene464	2.541e-28	118.0	COG3577@1|root,COG3577@2|Bacteria,1G6TW@1117|Cyanobacteria	1117|Cyanobacteria	S	Aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	gag-asp_proteas
TH1_k127_2772730_2	857087.Metme_3297	4.18e-198	623.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,1RMAW@1236|Gammaproteobacteria,1XERV@135618|Methylococcales	135618|Methylococcales	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
TH1_k127_2772730_3	697282.Mettu_0314	2.989e-134	441.0	COG0744@1|root,COG0768@1|root,COG0744@2|Bacteria,COG0768@2|Bacteria,1NRPB@1224|Proteobacteria,1RNG3@1236|Gammaproteobacteria,1XEBS@135618|Methylococcales	135618|Methylococcales	M	Transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	Transgly
TH1_k127_2796826_0	697282.Mettu_3840	1.596e-164	526.0	COG0477@1|root,COG2814@2|Bacteria,1QTWR@1224|Proteobacteria,1T1PC@1236|Gammaproteobacteria,1XERZ@135618|Methylococcales	135618|Methylococcales	EGP	PFAM Major Facilitator Superfamily	-	-	-	ko:K08227	-	-	-	-	ko00000,ko02000	2.A.1.42	-	-	MFS_1
TH1_k127_2796826_2	686340.Metal_1156	2.81e-49	183.0	COG1309@1|root,COG1309@2|Bacteria,1N0XU@1224|Proteobacteria,1S91U@1236|Gammaproteobacteria,1XFCH@135618|Methylococcales	135618|Methylococcales	K	PFAM Transcriptional regulator, TetR-like, DNA-binding, bacterial archaeal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
TH1_k127_2796826_1	697282.Mettu_1213	1.661e-89	303.0	COG3431@1|root,COG3431@2|Bacteria,1N6PE@1224|Proteobacteria,1T0WM@1236|Gammaproteobacteria,1XEZF@135618|Methylococcales	135618|Methylococcales	S	Sensors of blue-light using FAD	-	-	-	-	-	-	-	-	-	-	-	-	BLUF,PsiE
TH1_k127_2796826_3	113355.CM001775_gene2747	2.057e-14	73.0	COG1271@1|root,COG1271@2|Bacteria,1G2J8@1117|Cyanobacteria	1117|Cyanobacteria	C	Cytochrome bd-type quinol oxidase subunit 1	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	iJN678.cydA	Cyt_bd_oxida_I
TH1_k127_280750_6	697282.Mettu_3282	1.389e-43	159.0	COG1611@1|root,COG1611@2|Bacteria,1MVQJ@1224|Proteobacteria,1RQHX@1236|Gammaproteobacteria,1XEVC@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF4478)	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	DUF3412,DUF4478,Lysine_decarbox
TH1_k127_280750_2	686340.Metal_0113	7.098e-123	399.0	COG1028@1|root,COG1028@2|Bacteria,1MUCH@1224|Proteobacteria,1RNAA@1236|Gammaproteobacteria,1XDTD@135618|Methylococcales	135618|Methylococcales	IQ	short-chain dehydrogenase reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TH1_k127_280750_0	1283300.ATXB01000001_gene817	4.925e-196	620.0	COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,1RM8P@1236|Gammaproteobacteria,1XEM7@135618|Methylococcales	135618|Methylococcales	E	POT family	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
TH1_k127_280750_4	643562.Daes_2690	8.723e-81	279.0	COG2173@1|root,COG2173@2|Bacteria,1RENK@1224|Proteobacteria,42RT1@68525|delta/epsilon subdivisions,2X5CH@28221|Deltaproteobacteria,2MGPF@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide	ddpX	-	3.4.13.22	ko:K08641	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	Peptidase_M15
TH1_k127_280750_5	686340.Metal_2785	9.246e-48	173.0	COG0662@1|root,COG0662@2|Bacteria,1N00P@1224|Proteobacteria,1S759@1236|Gammaproteobacteria,1XFIZ@135618|Methylococcales	135618|Methylococcales	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TH1_k127_280750_9	1182590.BN5_03251	4.66e-11	65.0	COG1487@1|root,COG1487@2|Bacteria,1MZQC@1224|Proteobacteria,1SAJG@1236|Gammaproteobacteria,1YKEJ@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	vapC	-	-	ko:K07062	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN
TH1_k127_280750_8	686340.Metal_1632	1.114e-11	69.0	2AWKC@1|root,31NH3@2|Bacteria,1QK7Y@1224|Proteobacteria,1TIB8@1236|Gammaproteobacteria,1XGWS@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_280750_1	686340.Metal_0116	2.428e-162	516.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RN5G@1236|Gammaproteobacteria,1XESU@135618|Methylococcales	135618|Methylococcales	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TH1_k127_280750_3	697282.Mettu_1931	9.907e-109	361.0	COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,1RNNP@1236|Gammaproteobacteria,1XEJ0@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
TH1_k127_280750_7	686340.Metal_0118	2.172e-26	111.0	2C5QF@1|root,331W9@2|Bacteria,1N7AE@1224|Proteobacteria,1SCH2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4381)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4381
TH1_k127_2837425_0	697282.Mettu_4044	1.486e-313	994.0	COG1196@1|root,COG3264@1|root,COG1196@2|Bacteria,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1XE6E@135618|Methylococcales	135618|Methylococcales	M	Mechanosensitive ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel,MscS_TM,MscS_porin
TH1_k127_2837425_2	1137799.GZ78_21805	3.714e-105	347.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,1RP3J@1236|Gammaproteobacteria,1XH8W@135619|Oceanospirillales	135619|Oceanospirillales	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TH1_k127_2837425_1	697282.Mettu_0742	4.527e-129	424.0	COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,1RP5U@1236|Gammaproteobacteria,1XEHX@135618|Methylococcales	135618|Methylococcales	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
TH1_k127_2881920_8	857087.Metme_4525	6.021e-13	73.0	2B6TC@1|root,31ZSM@2|Bacteria,1QK6A@1224|Proteobacteria,1TI9J@1236|Gammaproteobacteria,1XGTJ@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_2881920_4	1244869.H261_16780	3.515e-114	378.0	COG2899@1|root,COG2899@2|Bacteria,1NURT@1224|Proteobacteria,2TRRF@28211|Alphaproteobacteria,2JVZ8@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF475
TH1_k127_2881920_1	697282.Mettu_2441	7.053e-278	859.0	COG3596@1|root,COG3596@2|Bacteria,1P6GT@1224|Proteobacteria,1RZFQ@1236|Gammaproteobacteria,1XF0X@135618|Methylococcales	135618|Methylococcales	S	50S ribosome-binding GTPase	-	-	-	ko:K06946	-	-	-	-	ko00000	-	-	-	MMR_HSR1
TH1_k127_2881920_2	697282.Mettu_2440	8.958e-225	699.0	COG3596@1|root,COG3597@1|root,COG3596@2|Bacteria,COG3597@2|Bacteria,1MV2B@1224|Proteobacteria,1RQTJ@1236|Gammaproteobacteria,1XEWI@135618|Methylococcales	135618|Methylococcales	S	50S ribosome-binding GTPase	-	-	-	-	-	-	-	-	-	-	-	-	DUF697,MMR_HSR1
TH1_k127_2881920_0	697282.Mettu_1851	0.0	1125.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria,1XEGH@135618|Methylococcales	135618|Methylococcales	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	-	3.1.11.5	ko:K03582	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
TH1_k127_2881920_3	697282.Mettu_1850	3.063e-175	565.0	COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,1RPA0@1236|Gammaproteobacteria,1XDV6@135618|Methylococcales	135618|Methylococcales	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD	recD	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,UvrD_C_2
TH1_k127_2881920_5	1131553.JIBI01000024_gene96	2.499e-39	154.0	COG0791@1|root,COG0791@2|Bacteria,1N0EE@1224|Proteobacteria,2VSHN@28216|Betaproteobacteria,373AQ@32003|Nitrosomonadales	28216|Betaproteobacteria	M	NlpC/P60 family	-	-	-	ko:K13695,ko:K19303	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60
TH1_k127_2881920_6	768671.ThimaDRAFT_1059	6.004e-34	132.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,1SCKA@1236|Gammaproteobacteria,1WYKM@135613|Chromatiales	135613|Chromatiales	S	RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
TH1_k127_2881920_7	857087.Metme_3258	4.524e-16	78.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008964,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0072350	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	iSFV_1184.SFV_4025	PEPcase
TH1_k127_2953518_0	697282.Mettu_4120	2.371e-302	930.0	COG0388@1|root,COG0388@2|Bacteria,1MX4I@1224|Proteobacteria,1RP30@1236|Gammaproteobacteria,1XENX@135618|Methylococcales	135618|Methylococcales	M	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,CN_hydrolase
TH1_k127_2953518_1	1116472.MGMO_84c00070	2.748e-71	246.0	COG1192@1|root,COG1192@2|Bacteria,1R62T@1224|Proteobacteria,1S58J@1236|Gammaproteobacteria,1XG72@135618|Methylococcales	135618|Methylococcales	D	Cellulose biosynthesis protein BcsQ	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31
TH1_k127_295637_9	7244.FBpp0225305	0.0007442	43.0	COG5290@1|root,KOG1920@2759|Eukaryota,39DM9@33154|Opisthokonta,3BD96@33208|Metazoa,3CYHV@33213|Bilateria,41TKU@6656|Arthropoda,3SGJG@50557|Insecta,44YBW@7147|Diptera,45P8N@7214|Drosophilidae	33208|Metazoa	K	Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation	IKBKAP	GO:0000003,GO:0000049,GO:0000123,GO:0000166,GO:0001932,GO:0002097,GO:0002098,GO:0002119,GO:0002164,GO:0002376,GO:0003006,GO:0003008,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004672,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006357,GO:0006366,GO:0006368,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006464,GO:0006468,GO:0006518,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006955,GO:0007154,GO:0007165,GO:0007249,GO:0007252,GO:0007275,GO:0007276,GO:0007281,GO:0007283,GO:0007292,GO:0007549,GO:0007610,GO:0007611,GO:0007612,GO:0007635,GO:0008023,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0008306,GO:0008355,GO:0008607,GO:0009047,GO:0009058,GO:0009059,GO:0009451,GO:0009653,GO:0009790,GO:0009791,GO:0009889,GO:0009987,GO:0009994,GO:0010467,GO:0010468,GO:0010556,GO:0016043,GO:0016070,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019207,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019538,GO:0019887,GO:0019953,GO:0022412,GO:0022414,GO:0022607,GO:0023052,GO:0030154,GO:0030234,GO:0030334,GO:0030335,GO:0030554,GO:0031248,GO:0031323,GO:0031326,GO:0031399,GO:0031974,GO:0031981,GO:0032268,GO:0032501,GO:0032502,GO:0032504,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032879,GO:0032991,GO:0033588,GO:0034470,GO:0034641,GO:0034645,GO:0034654,GO:0034660,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0036477,GO:0040012,GO:0040017,GO:0040025,GO:0040029,GO:0042048,GO:0042221,GO:0042325,GO:0042995,GO:0043005,GO:0043025,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043549,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044297,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0044703,GO:0045859,GO:0046483,GO:0048232,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048522,GO:0048569,GO:0048598,GO:0048599,GO:0048609,GO:0048731,GO:0048856,GO:0048869,GO:0050789,GO:0050790,GO:0050794,GO:0050877,GO:0050890,GO:0050896,GO:0051171,GO:0051174,GO:0051246,GO:0051252,GO:0051270,GO:0051272,GO:0051338,GO:0051704,GO:0051716,GO:0060255,GO:0065003,GO:0065007,GO:0065009,GO:0070013,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0097458,GO:0097659,GO:0098772,GO:0120025,GO:0140096,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902493,GO:1902494,GO:1903506,GO:1990234,GO:2000112,GO:2000145,GO:2000147,GO:2001141	-	ko:K11373	-	-	-	-	ko00000,ko03016,ko03036	-	-	-	IKI3
TH1_k127_295637_1	886293.Sinac_2565	0.0	1193.0	COG1452@1|root,COG1452@2|Bacteria,2J4VE@203682|Planctomycetes	203682|Planctomycetes	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_295637_3	697282.Mettu_4058	1.39e-147	476.0	COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,1RMKW@1236|Gammaproteobacteria,1XDPK@135618|Methylococcales	135618|Methylococcales	F	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
TH1_k127_295637_2	697282.Mettu_3923	5.222e-274	862.0	COG0204@1|root,COG1647@1|root,COG0204@2|Bacteria,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,1S1Y0@1236|Gammaproteobacteria,1XEI1@135618|Methylococcales	135618|Methylococcales	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
TH1_k127_295637_6	697282.Mettu_0390	8.423e-129	418.0	COG2234@1|root,COG2234@2|Bacteria,1MXZS@1224|Proteobacteria,1S0QR@1236|Gammaproteobacteria,1XFU4@135618|Methylococcales	135618|Methylococcales	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
TH1_k127_295637_0	686340.Metal_0575	0.0	1803.0	COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,1RQ34@1236|Gammaproteobacteria,1XDR7@135618|Methylococcales	135618|Methylococcales	KL	DNA RNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3670,Helicase_C,SNF2_N
TH1_k127_295637_4	686340.Metal_0574	3.445e-147	469.0	COG4279@1|root,COG4279@2|Bacteria,1N5C3@1224|Proteobacteria,1S187@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PFAM SWIM zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
TH1_k127_295637_5	697282.Mettu_0388	1.796e-143	458.0	COG1796@1|root,COG1796@2|Bacteria,1QF8Z@1224|Proteobacteria,1RRQ5@1236|Gammaproteobacteria,1XH0H@135618|Methylococcales	135618|Methylococcales	L	Helix-hairpin-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HHH_5,HHH_8
TH1_k127_2980830_0	686340.Metal_2566	9.23e-276	858.0	COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,1SBE1@1236|Gammaproteobacteria,1XG1W@135618|Methylococcales	135618|Methylococcales	V	ABC transporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
TH1_k127_2980830_1	686340.Metal_2565	1.203e-27	115.0	2E4XG@1|root,32ZRD@2|Bacteria,1N79W@1224|Proteobacteria,1SCEN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	tryptophan synthase subunit beta	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_2980830_3	686340.Metal_1635	1.253e-19	94.0	COG2197@1|root,COG2197@2|Bacteria,1PAWB@1224|Proteobacteria,1SUBW@1236|Gammaproteobacteria,1XGU0@135618|Methylococcales	135618|Methylococcales	KT	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_2980830_2	686340.Metal_3822	2.073e-27	116.0	COG2304@1|root,COG2931@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1S67V@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta
TH1_k127_3020460_2	1121378.KB899703_gene2290	1.57e-140	462.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
TH1_k127_3020460_3	1122951.ATUE01000006_gene1268	2.402e-28	119.0	COG3749@1|root,COG3749@2|Bacteria,1RJR9@1224|Proteobacteria,1S64S@1236|Gammaproteobacteria,3NT6E@468|Moraxellaceae	1236|Gammaproteobacteria	S	Bacterial protein of unknown function (DUF934)	-	-	-	-	-	-	-	-	-	-	-	-	DUF934
TH1_k127_3020460_0	857087.Metme_0277	3.602e-287	889.0	COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,1RMFH@1236|Gammaproteobacteria,1XEB1@135618|Methylococcales	135618|Methylococcales	C	reductase 4Fe-4S	-	-	1.8.1.2	ko:K00381	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
TH1_k127_3020460_1	697282.Mettu_2419	6.968e-190	599.0	COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,1RPSM@1236|Gammaproteobacteria,1XDPY@135618|Methylococcales	135618|Methylococcales	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
TH1_k127_304075_2	1049564.TevJSym_aj00680	1.109e-118	391.0	COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,1RN4G@1236|Gammaproteobacteria,1J5UK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG0277 FAD FMN-containing dehydrogenases	glcE	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	iETEC_1333.ETEC_3246	FAD-oxidase_C,FAD_binding_4
TH1_k127_304075_0	1123368.AUIS01000005_gene483	7.151e-151	486.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,2NBWP@225057|Acidithiobacillales	225057|Acidithiobacillales	C	4Fe-4S dicluster domain	glcF	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7
TH1_k127_304075_1	671143.DAMO_1127	1.274e-140	455.0	COG0510@1|root,COG0510@2|Bacteria	2|Bacteria	M	ethanolamine kinase activity	-	-	2.7.1.89	ko:K07251	ko00730,ko01100,map00730,map01100	-	R02134	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	APH,Choline_kinase,EcKinase
TH1_k127_304075_3	1116472.MGMO_66c00560	2.811e-72	248.0	COG1073@1|root,COG1073@2|Bacteria,1RKV2@1224|Proteobacteria,1S95V@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,UPF0227
TH1_k127_3048574_11	1208321.D104_10195	3.382e-12	69.0	COG5659@1|root,COG5659@2|Bacteria,1NT9K@1224|Proteobacteria,1SN0C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
TH1_k127_3048574_13	1229204.AMYY01000007_gene1237	8.334e-07	55.0	COG3126@1|root,COG3126@2|Bacteria,1N8AF@1224|Proteobacteria,2UGPH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Protein conserved in bacteria	-	-	-	ko:K09914	-	-	-	-	ko00000	-	-	-	META,YscW
TH1_k127_3048574_9	522306.CAP2UW1_2595	2.109e-21	96.0	COG3015@1|root,COG3126@1|root,COG3187@1|root,COG3015@2|Bacteria,COG3126@2|Bacteria,COG3187@2|Bacteria,1N8AF@1224|Proteobacteria,2VXB0@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Type III secretion system lipoprotein chaperone (YscW)	-	-	-	ko:K09914	-	-	-	-	ko00000	-	-	-	MliC,YscW
TH1_k127_3048574_8	522306.CAP2UW1_2595	9.045e-49	179.0	COG3015@1|root,COG3126@1|root,COG3187@1|root,COG3015@2|Bacteria,COG3126@2|Bacteria,COG3187@2|Bacteria,1N8AF@1224|Proteobacteria,2VXB0@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Type III secretion system lipoprotein chaperone (YscW)	-	-	-	ko:K09914	-	-	-	-	ko00000	-	-	-	MliC,YscW
TH1_k127_3048574_3	29581.BW37_00345	1.08e-128	433.0	COG0668@1|root,COG0668@2|Bacteria,1N66N@1224|Proteobacteria,2WGKB@28216|Betaproteobacteria,476H4@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
TH1_k127_3048574_2	1267533.KB906733_gene2861	1.599e-184	589.0	COG4320@1|root,COG4320@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
TH1_k127_3048574_5	1267533.KB906733_gene2856	1.623e-84	294.0	28M5B@1|root,2ZAJ4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_3048574_7	644968.DFW101_2930	4.733e-66	244.0	29D6U@1|root,3004T@2|Bacteria,1R9I1@1224|Proteobacteria,42T9I@68525|delta/epsilon subdivisions,2WPXB@28221|Deltaproteobacteria,2MADE@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_3048574_0	768671.ThimaDRAFT_0859	0.0	1357.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,1RPDE@1236|Gammaproteobacteria,1WWMT@135613|Chromatiales	135613|Chromatiales	P	PFAM Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
TH1_k127_3048574_10	1123242.JH636434_gene5326	4.338e-19	87.0	COG5361@1|root,COG5361@2|Bacteria,2IY8Y@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
TH1_k127_3048574_6	525897.Dbac_1083	6.841e-67	236.0	COG5361@1|root,COG5361@2|Bacteria,1NZZJ@1224|Proteobacteria,42WCT@68525|delta/epsilon subdivisions,2WRX3@28221|Deltaproteobacteria,2MEBR@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
TH1_k127_3048574_4	1265503.KB905160_gene2975	2.934e-110	365.0	COG4313@1|root,COG4313@2|Bacteria,1PC95@1224|Proteobacteria,1RZJZ@1236|Gammaproteobacteria,2Q8AT@267889|Colwelliaceae	1236|Gammaproteobacteria	C	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
TH1_k127_3048574_1	395964.KE386496_gene2906	1.247e-221	696.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2TSB8@28211|Alphaproteobacteria,3NCCR@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TH1_k127_3069148_6	697282.Mettu_0114	3.933e-48	179.0	COG1451@1|root,COG1451@2|Bacteria,1MXZU@1224|Proteobacteria,1S9E4@1236|Gammaproteobacteria,1XEYC@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
TH1_k127_3069148_4	857087.Metme_0480	4.861e-56	198.0	COG2346@1|root,COG2346@2|Bacteria,1RH21@1224|Proteobacteria,1S98H@1236|Gammaproteobacteria,1XF5V@135618|Methylococcales	135618|Methylococcales	S	Bacterial-like globin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
TH1_k127_3069148_2	1116472.MGMO_7c00140	5.602e-109	357.0	COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,1RRVZ@1236|Gammaproteobacteria,1XEBI@135618|Methylococcales	135618|Methylococcales	S	Belongs to the BI1 family	-	-	-	ko:K19416	-	M00742	-	-	ko00000,ko00002,ko02000	1.A.14.2.1	-	-	Bax1-I
TH1_k127_3069148_11	1116472.MGMO_7c00130	3.294e-26	115.0	2EBDF@1|root,335E4@2|Bacteria,1NH7B@1224|Proteobacteria,1SHGY@1236|Gammaproteobacteria,1XFM2@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_3069148_7	857087.Metme_4523	2.852e-43	166.0	2C3ZQ@1|root,32SCF@2|Bacteria,1N27R@1224|Proteobacteria,1S4HC@1236|Gammaproteobacteria,1XFHN@135618|Methylococcales	135618|Methylococcales	S	MEKHLA domain	-	-	-	-	-	-	-	-	-	-	-	-	MEKHLA
TH1_k127_3069148_9	999141.GME_08289	1.8e-32	129.0	COG2329@1|root,COG2329@2|Bacteria,1MZKW@1224|Proteobacteria,1S9N8@1236|Gammaproteobacteria,1XKXM@135619|Oceanospirillales	135619|Oceanospirillales	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
TH1_k127_3069148_1	1116472.MGMO_41c00170	5.997e-141	452.0	2BVW3@1|root,2Z7TB@2|Bacteria,1MY60@1224|Proteobacteria,1RNI9@1236|Gammaproteobacteria,1XEQJ@135618|Methylococcales	135618|Methylococcales	S	PFAM 5'-nucleotidase	-	-	3.1.3.5	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5-nucleotidase
TH1_k127_3069148_3	686340.Metal_2805	2.866e-72	246.0	COG1981@1|root,COG1981@2|Bacteria,1RHGS@1224|Proteobacteria,1S5XY@1236|Gammaproteobacteria,1XF45@135618|Methylococcales	135618|Methylococcales	S	PFAM Uncharacterised protein family (UPF0093)	-	-	-	ko:K08973	-	-	-	-	ko00000	-	-	-	UPF0093
TH1_k127_3069148_5	697282.Mettu_4334	1.757e-50	185.0	COG0526@1|root,COG0526@2|Bacteria,1RDGI@1224|Proteobacteria,1S8ZA@1236|Gammaproteobacteria,1XFDF@135618|Methylococcales	135618|Methylococcales	O	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TH1_k127_3069148_10	1116472.MGMO_24c00020	1.812e-31	129.0	2AW1V@1|root,31MWH@2|Bacteria,1QJNH@1224|Proteobacteria,1THPA@1236|Gammaproteobacteria,1XF5Y@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_3069148_0	1116472.MGMO_38c00220	4.682e-147	473.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,1RMGZ@1236|Gammaproteobacteria,1XEC8@135618|Methylococcales	135618|Methylococcales	C	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TH1_k127_3069148_8	857087.Metme_2697	7.453e-43	157.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,1RMNR@1236|Gammaproteobacteria,1XERX@135618|Methylococcales	135618|Methylococcales	E	Aminotransferase class-V	sgaA	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
TH1_k127_3069871_0	640081.Dsui_1429	3.359e-153	514.0	COG5000@1|root,COG5001@1|root,COG5000@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KV9J@206389|Rhodocyclales	206389|Rhodocyclales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_4,PAS_9,dCache_1
TH1_k127_3069871_1	349521.HCH_00947	1.503e-107	374.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1T23Q@1236|Gammaproteobacteria,1XRKI@135619|Oceanospirillales	135619|Oceanospirillales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TH1_k127_3069871_2	686340.Metal_1983	4.35e-87	293.0	COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,1RRT6@1236|Gammaproteobacteria,1XFBD@135618|Methylococcales	135618|Methylococcales	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TH1_k127_3069871_3	335543.Sfum_3616	2.456e-47	181.0	COG2304@1|root,COG2304@2|Bacteria,1MUTS@1224|Proteobacteria,42R8X@68525|delta/epsilon subdivisions,2WN6U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
TH1_k127_311770_0	697282.Mettu_2621	6.754e-150	479.0	COG1362@1|root,COG1362@2|Bacteria,1NT1D@1224|Proteobacteria,1RPHR@1236|Gammaproteobacteria,1XECI@135618|Methylococcales	135618|Methylococcales	E	M18 family aminopeptidase	-	-	3.4.11.21	ko:K01267	-	-	-	-	ko00000,ko01000,ko01002,ko04131	-	-	-	Peptidase_M18
TH1_k127_311770_1	686340.Metal_3954	4.402e-64	224.0	COG3145@1|root,COG3145@2|Bacteria,1RGXU@1224|Proteobacteria,1S6DD@1236|Gammaproteobacteria,1XF36@135618|Methylococcales	135618|Methylococcales	L	2OG-Fe(II) oxygenase	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2
TH1_k127_3141735_1	686340.Metal_3783	1.508e-111	362.0	COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,1RMFS@1236|Gammaproteobacteria,1XDJ1@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
TH1_k127_3141735_0	697282.Mettu_2877	6.266e-158	501.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria,1XDUT@135618|Methylococcales	135618|Methylococcales	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
TH1_k127_316063_1	535289.Dtpsy_2617	2.608e-128	429.0	COG0474@1|root,COG0474@2|Bacteria,1QWMC@1224|Proteobacteria,2VQCH@28216|Betaproteobacteria,4AHI0@80864|Comamonadaceae	28216|Betaproteobacteria	P	Domain of unknown function (DUF4153)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4153
TH1_k127_316063_4	686340.Metal_3053	4.056e-54	194.0	COG1853@1|root,COG1853@2|Bacteria,1RGYM@1224|Proteobacteria,1RSQV@1236|Gammaproteobacteria,1XF5N@135618|Methylococcales	135618|Methylococcales	S	PFAM Flavin	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
TH1_k127_316063_3	697282.Mettu_1034	2.696e-72	252.0	COG0558@1|root,COG0558@2|Bacteria,1N35Q@1224|Proteobacteria,1T0Q8@1236|Gammaproteobacteria,1XFBQ@135618|Methylococcales	135618|Methylococcales	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
TH1_k127_316063_2	1116472.MGMO_54c00080	5.85e-121	392.0	COG3568@1|root,COG3568@2|Bacteria,1MVN7@1224|Proteobacteria,1RNSP@1236|Gammaproteobacteria,1XEIP@135618|Methylococcales	135618|Methylococcales	L	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TH1_k127_316063_5	1116472.MGMO_54c00090	5.124e-43	162.0	COG0575@1|root,COG0575@2|Bacteria,1N4I3@1224|Proteobacteria,1SASF@1236|Gammaproteobacteria,1XFJZ@135618|Methylococcales	135618|Methylococcales	I	COG0575 CDP-diglyceride synthetase	-	-	-	-	-	-	-	-	-	-	-	-	CarS-like
TH1_k127_316063_7	1288494.EBAPG3_14490	2.005e-31	127.0	2EAWF@1|root,334XP@2|Bacteria,1NKSU@1224|Proteobacteria,2WBUR@28216|Betaproteobacteria,373I4@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_316063_6	261292.Nit79A3_2170	3.716e-33	135.0	COG0607@1|root,COG0607@2|Bacteria,1NM25@1224|Proteobacteria	1224|Proteobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TH1_k127_316063_0	686340.Metal_3904	5.419e-143	464.0	COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,1RMTJ@1236|Gammaproteobacteria,1XG9U@135618|Methylococcales	135618|Methylococcales	D	AFG1-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AFG1_ATPase
TH1_k127_3211967_1	1136163.M565_ctg5P1418	9.198e-27	112.0	COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,1RZXV@1236|Gammaproteobacteria,1XVZK@135623|Vibrionales	135623|Vibrionales	E	Peptidase dimerisation domain	-	-	-	ko:K13049	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TH1_k127_3211967_0	391595.RLO149_c037000	4.032e-250	783.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TT5E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
TH1_k127_3233122_0	697282.Mettu_0848	2.479e-89	299.0	COG2911@1|root,COG2911@2|Bacteria,1MW9V@1224|Proteobacteria,1S3FX@1236|Gammaproteobacteria,1XDS4@135618|Methylococcales	135618|Methylococcales	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_3233122_2	697282.Mettu_0882	1.507e-67	235.0	COG3784@1|root,COG3784@2|Bacteria,1MYIH@1224|Proteobacteria,1S8D2@1236|Gammaproteobacteria,1XEZY@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF1318)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1318
TH1_k127_3233122_1	697282.Mettu_0883	4.237e-69	241.0	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,1RN1D@1236|Gammaproteobacteria,1XDWN@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA	rlmD	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
TH1_k127_3286982_14	1116472.MGMO_85c00300	1.781e-24	109.0	28WQ2@1|root,2ZIPR@2|Bacteria,1P418@1224|Proteobacteria,1THQ6@1236|Gammaproteobacteria,1XF9Q@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_3286982_5	697282.Mettu_1758	8.261e-120	400.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,1XFYN@135618|Methylococcales	135618|Methylococcales	C	Cysteine-rich domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_8
TH1_k127_3286982_8	686340.Metal_3454	1.799e-91	303.0	2E3IN@1|root,32YH3@2|Bacteria,1NA7N@1224|Proteobacteria,1SCVH@1236|Gammaproteobacteria,1XDMN@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_3286982_6	686340.Metal_3453	1.12e-112	366.0	COG0450@1|root,COG0450@2|Bacteria,1MWPY@1224|Proteobacteria,1RN4S@1236|Gammaproteobacteria,1XET2@135618|Methylococcales	135618|Methylococcales	O	C-terminal domain of 1-Cys peroxiredoxin	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
TH1_k127_3286982_15	686340.Metal_3452	1.134e-13	74.0	2AW5V@1|root,31N0V@2|Bacteria,1QJSM@1224|Proteobacteria,1THTW@1236|Gammaproteobacteria,1XFPI@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_3286982_3	697282.Mettu_1918	1.754e-135	439.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,1RMBT@1236|Gammaproteobacteria,1XEGC@135618|Methylococcales	135618|Methylococcales	L	A G-specific adenine glycosylase	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,NUDIX_4
TH1_k127_3286982_13	857087.Metme_0408	2.327e-40	150.0	COG2924@1|root,COG2924@2|Bacteria,1MZ2V@1224|Proteobacteria,1S964@1236|Gammaproteobacteria,1XFJS@135618|Methylococcales	135618|Methylococcales	C	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Iron_traffic
TH1_k127_3286982_1	243233.MCA0056	7.17e-242	752.0	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,1RP95@1236|Gammaproteobacteria,1XE4H@135618|Methylococcales	135618|Methylococcales	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
TH1_k127_3286982_11	686340.Metal_0126	9.347e-58	202.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,1S5WR@1236|Gammaproteobacteria,1XFBH@135618|Methylococcales	135618|Methylococcales	O	Belongs to the thioredoxin family	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
TH1_k127_3286982_2	857087.Metme_4336	2.037e-208	653.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1XEUG@135618|Methylococcales	135618|Methylococcales	JKL	DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlB	-	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C
TH1_k127_3286982_7	697282.Mettu_1923	1.264e-96	319.0	COG0637@1|root,COG0637@2|Bacteria,1QTT8@1224|Proteobacteria,1T1GC@1236|Gammaproteobacteria,1XE2I@135618|Methylococcales	135618|Methylococcales	S	PFAM Haloacid dehalogenase-like hydrolase	-	-	3.1.3.5	ko:K20881	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
TH1_k127_3286982_9	1116472.MGMO_43c00030	2.566e-72	248.0	COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,1S3ZE@1236|Gammaproteobacteria,1XEB9@135618|Methylococcales	135618|Methylococcales	L	pfam nudix	-	-	-	ko:K08312	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
TH1_k127_3286982_16	857087.Metme_0554	2.792e-11	73.0	2AWIV@1|root,31Q2Y@2|Bacteria,1QIYV@1224|Proteobacteria,1TGVI@1236|Gammaproteobacteria,1XGT6@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_3286982_12	1122134.KB893650_gene1234	3.01e-43	165.0	COG3101@1|root,COG3101@2|Bacteria,1MWTG@1224|Proteobacteria,1RNHD@1236|Gammaproteobacteria,1XK0G@135619|Oceanospirillales	135619|Oceanospirillales	S	protein conserved in bacteria	-	-	-	ko:K09906	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	EpmC
TH1_k127_3286982_0	697282.Mettu_1490	5.814e-276	856.0	COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,1RPTG@1236|Gammaproteobacteria,1XEM6@135618|Methylococcales	135618|Methylococcales	F	Thymidine phosphorylase	-	-	2.4.2.4	ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
TH1_k127_3286982_4	697282.Mettu_1489	1.637e-125	412.0	COG0462@1|root,COG0462@2|Bacteria,1MUV7@1224|Proteobacteria,1RY55@1236|Gammaproteobacteria,1XDIV@135618|Methylococcales	135618|Methylococcales	F	Belongs to the ribose-phosphate pyrophosphokinase family	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
TH1_k127_3286982_10	1283300.ATXB01000001_gene1561	2.779e-70	241.0	COG0055@1|root,COG0055@2|Bacteria,1N6UZ@1224|Proteobacteria,1RNQW@1236|Gammaproteobacteria,1XDWQ@135618|Methylococcales	135618|Methylococcales	C	PFAM ATPase, F1 V1 A1 complex, alpha beta subunit, nucleotide-binding domain	-	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
TH1_k127_3325703_4	857087.Metme_0393	7.178e-07	51.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1XDSH@135618|Methylococcales	135618|Methylococcales	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
TH1_k127_3325703_0	686340.Metal_0063	2.613e-273	860.0	COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1XDNX@135618|Methylococcales	135618|Methylococcales	CO	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_7
TH1_k127_3325703_2	105559.Nwat_1975	8.257e-38	144.0	COG1324@1|root,COG1324@2|Bacteria,1N6TN@1224|Proteobacteria,1SCFM@1236|Gammaproteobacteria,1WYXG@135613|Chromatiales	135613|Chromatiales	P	Divalent ion tolerance protein	-	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
TH1_k127_3325703_1	857087.Metme_1738	6.641e-51	187.0	COG3030@1|root,COG3030@2|Bacteria,1MZJJ@1224|Proteobacteria,1S8XU@1236|Gammaproteobacteria,1XF3Y@135618|Methylococcales	135618|Methylococcales	S	PFAM FxsA cytoplasmic membrane protein	-	-	-	ko:K07113	-	-	-	-	ko00000	-	-	-	FxsA
TH1_k127_3325703_3	1116472.MGMO_138c00050	1.212e-25	107.0	2AVGE@1|root,31M8K@2|Bacteria,1QJSA@1224|Proteobacteria,1THTM@1236|Gammaproteobacteria,1XFNV@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
TH1_k127_3333822_9	392500.Swoo_3148	0.0005401	43.0	2BWZZ@1|root,2Z86E@2|Bacteria,1MW89@1224|Proteobacteria,1S85K@1236|Gammaproteobacteria,2QAXE@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2927)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2927
TH1_k127_3333822_4	697282.Mettu_2922	3.245e-74	257.0	COG0784@1|root,COG1891@1|root,COG0784@2|Bacteria,COG1891@2|Bacteria,1RGX0@1224|Proteobacteria,1S6UW@1236|Gammaproteobacteria,1XF0B@135618|Methylococcales	135618|Methylococcales	T	4-HFC-P synthase	-	-	-	-	-	-	-	-	-	-	-	-	4HFCP_synth
TH1_k127_3333822_5	1283300.ATXB01000001_gene1456	6.113e-72	250.0	COG2457@1|root,COG2457@2|Bacteria,1RD0V@1224|Proteobacteria,1S4RM@1236|Gammaproteobacteria,1XEYH@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF447)	-	-	-	ko:K09154	-	-	-	-	ko00000	-	-	-	DUF447
TH1_k127_3333822_1	697282.Mettu_2920	3.38e-234	732.0	COG0294@1|root,COG0294@2|Bacteria,1MWM3@1224|Proteobacteria,1RZMG@1236|Gammaproteobacteria,1XEAQ@135618|Methylococcales	135618|Methylococcales	H	PFAM Dihydropteroate synthase, DHPS	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_3333822_8	1116472.MGMO_8c00310	8.834e-07	50.0	COG1036@1|root,COG1036@2|Bacteria,1RD5I@1224|Proteobacteria,1S59C@1236|Gammaproteobacteria,1XDQH@135618|Methylococcales	135618|Methylococcales	C	PFAM Flavoprotein	-	-	-	-	-	-	-	-	-	-	-	-	Flavoprotein
TH1_k127_3333822_0	686340.Metal_1824	3.436e-313	970.0	COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,1XEX2@135618|Methylococcales	135618|Methylococcales	V	Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K05685	ko02010,map02010	M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
TH1_k127_3333822_2	686340.Metal_1823	3.073e-145	470.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,1RN0E@1236|Gammaproteobacteria,1XEP7@135618|Methylococcales	135618|Methylococcales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	HlyD_D23
TH1_k127_3333822_7	686340.Metal_2731	6.929e-55	195.0	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,1S82I@1236|Gammaproteobacteria,1XF73@135618|Methylococcales	135618|Methylococcales	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
TH1_k127_3333822_3	857087.Metme_4601	1.598e-97	332.0	COG0811@1|root,COG0811@2|Bacteria,1RA2U@1224|Proteobacteria,1RPZ5@1236|Gammaproteobacteria,1XE5S@135618|Methylococcales	135618|Methylococcales	U	MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
TH1_k127_3333822_6	857087.Metme_2867	1.152e-63	227.0	COG0810@1|root,COG0810@2|Bacteria,1MZPX@1224|Proteobacteria,1SCVJ@1236|Gammaproteobacteria,1XF4A@135618|Methylococcales	135618|Methylococcales	U	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
TH1_k127_3343273_1	697282.Mettu_1869	2.485e-193	606.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria,1XESH@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
TH1_k127_3343273_0	1116472.MGMO_83c00110	1.068e-296	916.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria,1XDZD@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
TH1_k127_3343273_2	251221.35211561	1.001e-33	133.0	COG0058@1|root,COG0058@2|Bacteria,1FZUX@1117|Cyanobacteria	1117|Cyanobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
TH1_k127_3476487_4	1042326.AZNV01000044_gene703	3.665e-128	417.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,2TT0G@28211|Alphaproteobacteria,4B93F@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Sulfate permease and related transporters (MFS superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
TH1_k127_3476487_3	1210884.HG799469_gene14124	4.559e-135	435.0	COG2326@1|root,COG2326@2|Bacteria,2IYWN@203682|Planctomycetes	203682|Planctomycetes	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
TH1_k127_3476487_0	765913.ThidrDRAFT_3270	5.343e-246	772.0	COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1RSFG@1236|Gammaproteobacteria,1WWAZ@135613|Chromatiales	135613|Chromatiales	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
TH1_k127_3476487_8	102129.Lepto7375DRAFT_2666	8.295e-47	176.0	28P4X@1|root,2ZC02@2|Bacteria,1G5WW@1117|Cyanobacteria,1HD6F@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF2764)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2764
TH1_k127_3476487_7	756272.Plabr_3016	2.964e-58	210.0	COG1390@1|root,COG1390@2|Bacteria,2J4IC@203682|Planctomycetes	203682|Planctomycetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	-	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	-
TH1_k127_3476487_6	756272.Plabr_3017	1.223e-59	209.0	COG0636@1|root,COG0636@2|Bacteria	2|Bacteria	C	ATP hydrolysis coupled proton transport	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042802,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110,ko:K02124	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157,M00159	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1,3.A.2.2,3.A.2.3	-	-	ATP-synt_C
TH1_k127_3476487_2	756272.Plabr_3018	1.194e-172	559.0	COG1269@1|root,COG1269@2|Bacteria,2J3SY@203682|Planctomycetes	203682|Planctomycetes	U	V-type ATPase 116kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
TH1_k127_3476487_5	756272.Plabr_3019	1.939e-66	232.0	COG1394@1|root,COG1394@2|Bacteria,2J3Y9@203682|Planctomycetes	203682|Planctomycetes	C	ATP synthase subunit D	-	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
TH1_k127_3476487_1	756272.Plabr_3020	1.497e-238	742.0	COG1156@1|root,COG1156@2|Bacteria,2J2EX@203682|Planctomycetes	203682|Planctomycetes	C	ATP synthase alpha/beta family, beta-barrel domain	-	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
TH1_k127_3520230_6	1123487.KB892868_gene1263	1.247e-27	114.0	COG0542@1|root,COG0542@2|Bacteria,1MWQQ@1224|Proteobacteria,2VH2V@28216|Betaproteobacteria,2KVXD@206389|Rhodocyclales	206389|Rhodocyclales	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_2,ClpB_D2-small
TH1_k127_3520230_7	1415778.JQMM01000001_gene2177	8.817e-26	109.0	2E70X@1|root,331JP@2|Bacteria,1N81S@1224|Proteobacteria,1SCI0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter	-	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATPase_gene1
TH1_k127_3520230_2	697282.Mettu_0381	8.113e-91	303.0	COG0356@1|root,COG0356@2|Bacteria,1RBEV@1224|Proteobacteria,1T170@1236|Gammaproteobacteria,1XEY5@135618|Methylococcales	135618|Methylococcales	C	it plays a direct role in the translocation of protons across the membrane	-	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
TH1_k127_3520230_5	697282.Mettu_0380	5.871e-35	135.0	COG0636@1|root,COG0636@2|Bacteria,1NAIE@1224|Proteobacteria,1SA80@1236|Gammaproteobacteria,1XFH6@135618|Methylococcales	135618|Methylococcales	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	-	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
TH1_k127_3520230_4	1415778.JQMM01000001_gene2180	1.181e-53	197.0	COG0711@1|root,COG0711@2|Bacteria,1R6C0@1224|Proteobacteria,1S4NA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B,OSCP
TH1_k127_3520230_1	1415778.JQMM01000001_gene2181	2.168e-218	690.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1J5DU@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA1	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
TH1_k127_3520230_3	697282.Mettu_0377	1.679e-64	242.0	COG0224@1|root,COG0224@2|Bacteria,1RIE5@1224|Proteobacteria,1S3ZW@1236|Gammaproteobacteria,1XF9U@135618|Methylococcales	135618|Methylococcales	C	ATP synthase	-	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
TH1_k127_3520230_0	879212.DespoDRAFT_00173	1.441e-225	711.0	COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,42N9K@68525|delta/epsilon subdivisions,2WINH@28221|Deltaproteobacteria,2MJCW@213118|Desulfobacterales	28221|Deltaproteobacteria	V	PFAM N-6 DNA methylase	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
TH1_k127_3525577_3	697282.Mettu_0335	1.062e-24	104.0	COG0741@1|root,COG0741@2|Bacteria,1MWRW@1224|Proteobacteria,1S084@1236|Gammaproteobacteria,1XEU5@135618|Methylococcales	135618|Methylococcales	M	lytic transglycosylase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_3525577_1	1283300.ATXB01000001_gene1076	2.179e-98	334.0	COG3336@1|root,COG3336@2|Bacteria,1RAW2@1224|Proteobacteria,1S3HN@1236|Gammaproteobacteria,1XGPI@135618|Methylococcales	135618|Methylococcales	S	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)	-	-	-	-	-	-	-	-	-	-	-	-	Caa3_CtaG
TH1_k127_3525577_0	686340.Metal_2823	6.218e-111	362.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,1RMG9@1236|Gammaproteobacteria,1XETJ@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
TH1_k127_3525577_2	686340.Metal_2822	4.78e-32	126.0	COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,1RNQZ@1236|Gammaproteobacteria,1XDUJ@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
TH1_k127_3548320_4	857087.Metme_2139	6.92e-30	122.0	COG2009@1|root,COG2009@2|Bacteria,1N02N@1224|Proteobacteria,1SBDX@1236|Gammaproteobacteria,1XFGY@135618|Methylococcales	135618|Methylococcales	C	Succinate dehydrogenase, cytochrome b556 subunit	-	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
TH1_k127_3548320_5	697282.Mettu_0492	8.066e-19	91.0	COG2142@1|root,COG2142@2|Bacteria,1MZND@1224|Proteobacteria,1SAC6@1236|Gammaproteobacteria,1XFSH@135618|Methylococcales	135618|Methylococcales	C	succinate dehydrogenase, hydrophobic membrane anchor	-	-	-	ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
TH1_k127_3548320_1	857087.Metme_2141	1.316e-317	979.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1XEID@135618|Methylococcales	135618|Methylococcales	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TH1_k127_3548320_2	1198232.CYCME_1534	1.417e-137	440.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,1RNWR@1236|Gammaproteobacteria,46099@72273|Thiotrichales	72273|Thiotrichales	C	Succinate dehydrogenase fumarate reductase	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_17
TH1_k127_3548320_6	857087.Metme_2143	7.631e-16	80.0	COG2938@1|root,COG2938@2|Bacteria,1N7P4@1224|Proteobacteria,1SCKB@1236|Gammaproteobacteria,1XFWP@135618|Methylococcales	135618|Methylococcales	S	Flavinator of succinate dehydrogenase	-	-	-	ko:K09159	-	-	-	-	ko00000,ko02048	-	-	-	Sdh5
TH1_k127_3548320_3	697282.Mettu_0641	1.402e-50	181.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,1S8Z7@1236|Gammaproteobacteria,1XFEC@135618|Methylococcales	135618|Methylococcales	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
TH1_k127_3548320_0	243233.MCA1789	0.0	1148.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,1XEC1@135618|Methylococcales	135618|Methylococcales	O	ATP-dependent Clp protease, ATP-binding subunit ClpA	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
TH1_k127_3577313_16	857087.Metme_1416	5.071e-06	50.0	2AW8G@1|root,31N3R@2|Bacteria,1QJVB@1224|Proteobacteria,1THWY@1236|Gammaproteobacteria,1XFX1@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_3577313_6	667121.ET1_04_00530	4.506e-104	347.0	COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,1RN7T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	cysB	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0097159,GO:1901363	-	ko:K13634	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
TH1_k127_3577313_13	1035191.HMPREF0185_00159	2.038e-12	68.0	COG0122@1|root,COG0122@2|Bacteria,1MX9C@1224|Proteobacteria,2TVJ7@28211|Alphaproteobacteria,2KGJV@204458|Caulobacterales	204458|Caulobacterales	L	endonuclease III	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
TH1_k127_3577313_8	697282.Mettu_1762	4.335e-48	184.0	COG1711@1|root,COG1711@2|Bacteria,1RIA0@1224|Proteobacteria,1S715@1236|Gammaproteobacteria,1XF8A@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF3014)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3014
TH1_k127_3577313_4	857087.Metme_4443	7.883e-136	437.0	COG1586@1|root,COG1586@2|Bacteria,1MXPT@1224|Proteobacteria,1RQSX@1236|Gammaproteobacteria,1XEB4@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speD	-	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc
TH1_k127_3577313_7	697282.Mettu_1760	4.387e-62	217.0	COG1765@1|root,COG1765@2|Bacteria,1RCZW@1224|Proteobacteria,1S3XF@1236|Gammaproteobacteria,1XF3A@135618|Methylococcales	135618|Methylococcales	O	OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
TH1_k127_3577313_0	1116472.MGMO_97c00230	1.675e-296	915.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,1XER9@135618|Methylococcales	135618|Methylococcales	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
TH1_k127_3577313_9	1116472.MGMO_97c00220	8.045e-45	164.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,1S8YR@1236|Gammaproteobacteria,1XFAE@135618|Methylococcales	135618|Methylococcales	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
TH1_k127_3577313_5	697282.Mettu_3227	1.039e-113	372.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,1RPJ3@1236|Gammaproteobacteria,1XDNG@135618|Methylococcales	135618|Methylococcales	H	ThiF family	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
TH1_k127_3577313_14	1116472.MGMO_97c00200	1.974e-08	58.0	2AUTR@1|root,31KGT@2|Bacteria,1QIBZ@1224|Proteobacteria,1TG68@1236|Gammaproteobacteria,1XFSA@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_3577313_2	697282.Mettu_3230	3.097e-166	526.0	COG1235@1|root,COG1235@2|Bacteria,1MWI5@1224|Proteobacteria,1RMM9@1236|Gammaproteobacteria,1XESM@135618|Methylococcales	135618|Methylococcales	S	May be involved in the transport of PQQ or its precursor to the periplasm	pqqB	GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0018130,GO:0018189,GO:0018193,GO:0018212,GO:0019538,GO:0019752,GO:0034641,GO:0036211,GO:0042180,GO:0042181,GO:0042364,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072350,GO:0072351,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901661,GO:1901663	-	ko:K06136	-	-	-	-	ko00000	-	-	-	Lactamase_B_2
TH1_k127_3577313_3	686340.Metal_3577	1.133e-144	461.0	COG5424@1|root,COG5424@2|Bacteria,1MW7G@1224|Proteobacteria,1RP1V@1236|Gammaproteobacteria,1XED1@135618|Methylococcales	135618|Methylococcales	H	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ	pqqC	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	TENA_THI-4
TH1_k127_3577313_12	765911.Thivi_0433	8.798e-26	109.0	COG4636@1|root,COG4636@2|Bacteria,1RGFN@1224|Proteobacteria,1S4C8@1236|Gammaproteobacteria,1WYH3@135613|Chromatiales	135613|Chromatiales	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
TH1_k127_3577313_10	1116472.MGMO_97c00100	6.565e-37	141.0	2E4CK@1|root,32Z81@2|Bacteria,1N7JR@1224|Proteobacteria,1SCEZ@1236|Gammaproteobacteria,1XFGZ@135618|Methylococcales	135618|Methylococcales	S	TIGRFAM coenzyme PQQ biosynthesis protein PqqD	pqqD	GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0018130,GO:0018189,GO:0018193,GO:0018212,GO:0019538,GO:0019752,GO:0034641,GO:0036211,GO:0042180,GO:0042181,GO:0042364,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072350,GO:0072351,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901661,GO:1901663	-	ko:K06138	-	-	-	-	ko00000	-	-	-	PqqD
TH1_k127_3577313_1	697282.Mettu_3233	5.998e-208	652.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,1RMR1@1236|Gammaproteobacteria,1XE8I@135618|Methylococcales	135618|Methylococcales	H	TIGRFAM Coenzyme PQQ biosynthesis protein E	pqqE	GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0018130,GO:0018189,GO:0018193,GO:0018212,GO:0019538,GO:0019752,GO:0034641,GO:0036211,GO:0042180,GO:0042181,GO:0042364,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072350,GO:0072351,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901661,GO:1901663	-	ko:K06139	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
TH1_k127_3577313_11	506534.Rhein_0729	7.552e-31	126.0	COG0642@1|root,COG4251@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG4251@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1WVYT@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3
TH1_k127_358240_0	686340.Metal_1357	2.867e-318	977.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPWS@1236|Gammaproteobacteria,1XE4C@135618|Methylococcales	135618|Methylococcales	S	TIGRFAM ATP-binding cassette protein, ChvD family	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
TH1_k127_358240_3	857087.Metme_3298	1.711e-125	406.0	COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,1RMCZ@1236|Gammaproteobacteria,1XDJ7@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
TH1_k127_358240_2	697282.Mettu_2606	7.093e-197	618.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria,1XEWP@135618|Methylococcales	135618|Methylococcales	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0006457,GO:0008150,GO:0009987	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
TH1_k127_358240_1	686340.Metal_2046	9.732e-212	662.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,1XDUN@135618|Methylococcales	135618|Methylococcales	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
TH1_k127_3610778_0	857087.Metme_1092	7.971e-174	556.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RN70@1236|Gammaproteobacteria,1XDT5@135618|Methylococcales	135618|Methylococcales	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
TH1_k127_3610778_1	857087.Metme_3167	1.465e-85	290.0	COG4089@1|root,COG4089@2|Bacteria,1MV8K@1224|Proteobacteria,1S5RT@1236|Gammaproteobacteria,1XFNH@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF1614)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1614
TH1_k127_3610778_2	1121937.AUHJ01000019_gene1316	2.477e-65	227.0	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,1S3WP@1236|Gammaproteobacteria,466WC@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
TH1_k127_3610778_3	686340.Metal_1850	2.532e-27	124.0	COG4783@1|root,COG4783@2|Bacteria,1QXK9@1224|Proteobacteria,1T3M0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
TH1_k127_3687907_2	857087.Metme_2637	6.481e-86	291.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1XEKH@135618|Methylococcales	135618|Methylococcales	L	Bacterial DNA polymerase III, alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
TH1_k127_3687907_0	697282.Mettu_0413	1.341e-218	689.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,1RNMP@1236|Gammaproteobacteria,1XEKR@135618|Methylococcales	135618|Methylococcales	F	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
TH1_k127_3687907_3	1116472.MGMO_53c00430	5.919e-61	223.0	COG4796@1|root,COG4796@2|Bacteria,1RCNA@1224|Proteobacteria,1SE5I@1236|Gammaproteobacteria,1XFB4@135618|Methylococcales	135618|Methylococcales	U	Belongs to the GSP D family	-	-	-	-	-	-	-	-	-	-	-	-	Secretin
TH1_k127_3687907_1	582744.Msip34_0545	1.88e-90	306.0	COG0741@1|root,COG0790@1|root,COG0741@2|Bacteria,COG0790@2|Bacteria,1MZ4X@1224|Proteobacteria,2VM6E@28216|Betaproteobacteria,2KKV8@206350|Nitrosomonadales	206350|Nitrosomonadales	M	SMART Sel1 domain protein repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	SLT
TH1_k127_3697302_1	243233.MCA1848	1.87e-41	157.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1XE3D@135618|Methylococcales	135618|Methylococcales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
TH1_k127_3697302_0	396588.Tgr7_2295	0.0	1422.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1WX68@135613|Chromatiales	135613|Chromatiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
TH1_k127_3728801_2	857087.Metme_0256	3.007e-46	168.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,1XE3P@135618|Methylococcales	135618|Methylococcales	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
TH1_k127_3728801_1	857087.Metme_0255	2.766e-56	208.0	COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,1S9FJ@1236|Gammaproteobacteria,1XEYV@135618|Methylococcales	135618|Methylococcales	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
TH1_k127_3728801_0	697282.Mettu_1518	9.13e-196	614.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,1XEK3@135618|Methylococcales	135618|Methylococcales	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
TH1_k127_37320_0	686340.Metal_0067	0.0	1046.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1XEAI@135618|Methylococcales	135618|Methylococcales	L	DNA helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
TH1_k127_376383_0	697282.Mettu_4085	0.0	1358.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1XEFT@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
TH1_k127_376383_4	857087.Metme_3874	2.271e-36	143.0	COG2137@1|root,COG2137@2|Bacteria,1N6P6@1224|Proteobacteria,1SCMF@1236|Gammaproteobacteria,1XFIV@135618|Methylococcales	135618|Methylococcales	S	Modulates RecA activity	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
TH1_k127_376383_2	697282.Mettu_4087	2.083e-186	587.0	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,1RMHP@1236|Gammaproteobacteria,1XE0Z@135618|Methylococcales	135618|Methylococcales	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
TH1_k127_376383_5	1173029.JH980292_gene2841	2.057e-14	73.0	COG4974@1|root,COG4974@2|Bacteria,1G224@1117|Cyanobacteria,1H8SW@1150|Oscillatoriales	1117|Cyanobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
TH1_k127_376383_1	857087.Metme_0507	6.995e-244	760.0	COG2244@1|root,COG2244@2|Bacteria,1R512@1224|Proteobacteria,1RZ0F@1236|Gammaproteobacteria,1XE8D@135618|Methylococcales	135618|Methylococcales	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
TH1_k127_376383_3	1116472.MGMO_10c00120	8.523e-167	538.0	28H91@1|root,2Z7KU@2|Bacteria,1R4NB@1224|Proteobacteria,1S6NY@1236|Gammaproteobacteria,1XG9N@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_3765998_1	697282.Mettu_1439	1.202e-195	617.0	COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,1RN9V@1236|Gammaproteobacteria,1XE92@135618|Methylococcales	135618|Methylococcales	C	UPF0313 protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
TH1_k127_3765998_0	697282.Mettu_3696	0.0	1495.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,1RND3@1236|Gammaproteobacteria,1XEFG@135618|Methylococcales	135618|Methylococcales	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019464,GO:0019752,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
TH1_k127_3765998_3	697282.Mettu_3697	5.462e-126	415.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,1XDXV@135618|Methylococcales	135618|Methylococcales	H	Glycine cleavage system T protein	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
TH1_k127_3765998_2	1123392.AQWL01000010_gene2299	1e-164	524.0	COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,2VH2S@28216|Betaproteobacteria,1KS7Y@119069|Hydrogenophilales	119069|Hydrogenophilales	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
TH1_k127_377218_6	27679.XP_003930546.1	1.11e-31	141.0	28K3T@1|root,2QSIA@2759|Eukaryota,3974K@33154|Opisthokonta,3BBX0@33208|Metazoa,3CV1I@33213|Bilateria,485N6@7711|Chordata,4962A@7742|Vertebrata,3JD7X@40674|Mammalia,35B3B@314146|Euarchontoglires,4M7IG@9443|Primates	33208|Metazoa	S	Transmembrane protein 260	TMEM260	-	-	-	-	-	-	-	-	-	-	-	DUF2723
TH1_k127_377218_2	686340.Metal_1007	1.112e-144	464.0	COG0421@1|root,COG0421@2|Bacteria,1MVV5@1224|Proteobacteria,1RMUT@1236|Gammaproteobacteria,1XDNB@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
TH1_k127_377218_4	697282.Mettu_2184	2.769e-85	287.0	COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,1RNJP@1236|Gammaproteobacteria,1XE8S@135618|Methylococcales	135618|Methylococcales	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
TH1_k127_377218_3	857087.Metme_0151	6.002e-86	293.0	COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,1RZFP@1236|Gammaproteobacteria,1XEW3@135618|Methylococcales	135618|Methylococcales	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
TH1_k127_377218_0	1198232.CYCME_2488	6.821e-190	614.0	COG1333@1|root,COG1333@2|Bacteria,1N6XE@1224|Proteobacteria,1RXXZ@1236|Gammaproteobacteria,46045@72273|Thiotrichales	72273|Thiotrichales	O	Cytochrome c-type biogenesis protein Ccs1 ResB	-	-	-	ko:K07399	-	-	-	-	ko00000	-	-	-	ResB
TH1_k127_377218_5	686340.Metal_0734	1.989e-69	242.0	COG0590@1|root,COG0590@2|Bacteria,1RGU0@1224|Proteobacteria,1S60Z@1236|Gammaproteobacteria,1XEYZ@135618|Methylococcales	135618|Methylococcales	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
TH1_k127_377218_1	697282.Mettu_3282	1.407e-184	580.0	COG1611@1|root,COG1611@2|Bacteria,1MVQJ@1224|Proteobacteria,1RQHX@1236|Gammaproteobacteria,1XEVC@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF4478)	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	DUF3412,DUF4478,Lysine_decarbox
TH1_k127_3781746_5	768671.ThimaDRAFT_1901	3.145e-16	89.0	COG1196@1|root,COG1196@2|Bacteria,1R4K3@1224|Proteobacteria,1S0YG@1236|Gammaproteobacteria,1WZFJ@135613|Chromatiales	135613|Chromatiales	D	Plasmid replication region DNA-binding N-term	-	-	-	-	-	-	-	-	-	-	-	-	KfrA_N
TH1_k127_3781746_2	686340.Metal_4013	1.734e-66	230.0	COG0758@1|root,COG0758@2|Bacteria,1MZGB@1224|Proteobacteria,1S95S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	LU	Putative molybdenum carrier	-	-	-	-	-	-	-	-	-	-	-	-	MoCo_carrier
TH1_k127_3781746_3	686340.Metal_4012	2.649e-62	219.0	2AV8V@1|root,31KZQ@2|Bacteria,1QIUW@1224|Proteobacteria,1TGQU@1236|Gammaproteobacteria,1XGCR@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_3781746_1	686340.Metal_4011	1.446e-66	231.0	2DP69@1|root,330Q1@2|Bacteria,1N6RB@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_3781746_0	686340.Metal_4010	2.06e-128	411.0	COG1192@1|root,COG1192@2|Bacteria,1MWRE@1224|Proteobacteria,1RTVR@1236|Gammaproteobacteria,1XGRQ@135618|Methylococcales	135618|Methylococcales	D	Anion-transporting ATPase	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
TH1_k127_3781746_4	335283.Neut_2558	5.389e-20	94.0	2C4B0@1|root,30WGG@2|Bacteria,1PI5J@1224|Proteobacteria,2W6RP@28216|Betaproteobacteria,374GA@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_3781746_6	686340.Metal_2365	2.195e-12	72.0	2C4B0@1|root,33JT2@2|Bacteria,1NPR4@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_3794728_2	1116472.MGMO_85c00150	2.064e-95	316.0	COG4191@1|root,COG4191@2|Bacteria,1MVK7@1224|Proteobacteria,1S0T1@1236|Gammaproteobacteria,1XDN7@135618|Methylococcales	135618|Methylococcales	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TH1_k127_3794728_1	1116472.MGMO_85c00140	6.625e-238	742.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XE5A@135618|Methylococcales	135618|Methylococcales	T	SMART Signal transduction response regulator, receiver region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH1_k127_3794728_0	857087.Metme_3931	0.0	1034.0	COG0577@1|root,COG0577@2|Bacteria,1PJZX@1224|Proteobacteria,1RU56@1236|Gammaproteobacteria,1XDTW@135618|Methylococcales	135618|Methylococcales	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TH1_k127_3794728_3	1116472.MGMO_20c00290	3.243e-52	185.0	COG0607@1|root,COG0607@2|Bacteria,1QJP7@1224|Proteobacteria,1THQ5@1236|Gammaproteobacteria,1XF9P@135618|Methylococcales	135618|Methylococcales	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TH1_k127_3800888_3	697282.Mettu_2825	1.214e-14	74.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,1XDUD@135618|Methylococcales	135618|Methylococcales	E	Chorismate mutase type II	pheA	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
TH1_k127_3800888_0	1116472.MGMO_29c00180	2.641e-154	497.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1XDK1@135618|Methylococcales	135618|Methylococcales	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TH1_k127_3800888_2	1232683.ADIMK_0388	1.578e-80	278.0	COG0128@1|root,COG0287@1|root,COG0128@2|Bacteria,COG0287@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,46511@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	1.3.1.12,1.3.1.43,2.5.1.19	ko:K00210,ko:K00220,ko:K00800	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00022,M00025,M00040	R00732,R01728,R03460	RC00125,RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase,PDH
TH1_k127_3800888_1	857087.Metme_1881	2.199e-94	312.0	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,1XE66@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
TH1_k127_3803847_1	697282.Mettu_3207	1.064e-06	52.0	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,1S3UP@1236|Gammaproteobacteria,1XEZP@135618|Methylococcales	135618|Methylococcales	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
TH1_k127_3803847_0	756272.Plabr_3346	1.483e-93	328.0	COG0733@1|root,COG0733@2|Bacteria,2J29X@203682|Planctomycetes	203682|Planctomycetes	S	Sodium:neurotransmitter symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SNF
TH1_k127_3811864_2	697282.Mettu_0700	6.299e-90	303.0	COG1912@1|root,COG1912@2|Bacteria,1MV99@1224|Proteobacteria,1RQES@1236|Gammaproteobacteria,1XF1I@135618|Methylococcales	135618|Methylococcales	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
TH1_k127_3811864_1	1116472.MGMO_122c00100	9.221e-151	480.0	COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,1RN2H@1236|Gammaproteobacteria,1XER0@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system	ttcA	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
TH1_k127_3811864_0	1116472.MGMO_122c00140	3.972e-190	596.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1XDY1@135618|Methylococcales	135618|Methylococcales	IQ	Belongs to the beta-ketoacyl-ACP synthases family	fabB	-	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TH1_k127_3820181_1	697282.Mettu_2397	1.121e-202	635.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1XENG@135618|Methylococcales	135618|Methylococcales	H	Thiamine pyrophosphate enzyme, N-terminal TPP binding	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TH1_k127_3820181_0	243233.MCA1252	1.423e-289	905.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1XEST@135618|Methylococcales	135618|Methylococcales	C	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for	hppA	-	3.6.1.1	ko:K01507,ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
TH1_k127_3820181_2	686340.Metal_2402	2.567e-63	221.0	COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,1S3U8@1236|Gammaproteobacteria,1XEN4@135618|Methylococcales	135618|Methylococcales	M	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	dsbC	-	5.3.4.1	ko:K03981	-	-	-	-	ko00000,ko01000,ko02044,ko03110	3.A.7.11.1	-	-	DsbC_N,Thioredoxin_2
TH1_k127_3842439_4	1049564.TevJSym_aj00680	1.444e-39	150.0	COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,1RN4G@1236|Gammaproteobacteria,1J5UK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG0277 FAD FMN-containing dehydrogenases	glcE	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	iETEC_1333.ETEC_3246	FAD-oxidase_C,FAD_binding_4
TH1_k127_3842439_5	697282.Mettu_0675	4.451e-27	119.0	2AVBR@1|root,31M31@2|Bacteria,1QIY8@1224|Proteobacteria,1TGUW@1236|Gammaproteobacteria,1XGRJ@135618|Methylococcales	135618|Methylococcales	S	Peptidoglycan-binding protein, CsiV	-	-	-	-	-	-	-	-	-	-	-	-	CsiV
TH1_k127_3842439_2	261292.Nit79A3_2356	6.124e-66	228.0	COG2193@1|root,COG2193@2|Bacteria,1RD4Y@1224|Proteobacteria,2VQG7@28216|Betaproteobacteria,373W1@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Ferritin-like domain	bfrA	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
TH1_k127_3842439_0	697282.Mettu_3586	5.732e-141	461.0	COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,1RNG1@1236|Gammaproteobacteria,1XF81@135618|Methylococcales	135618|Methylococcales	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region	-	-	2.7.13.3	ko:K07640	ko01503,ko02020,map01503,map02020	M00447,M00727,M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
TH1_k127_3842439_1	1454004.AW11_02766	4.344e-86	291.0	COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,2VJB0@28216|Betaproteobacteria	28216|Betaproteobacteria	KT	response regulator	-	-	-	ko:K07662	ko01503,ko02020,map01503,map02020	M00447,M00727,M00728	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TH1_k127_3842439_6	697282.Mettu_3588	1.622e-16	89.0	COG3678@1|root,COG3678@2|Bacteria,1PCD7@1224|Proteobacteria,1SXBT@1236|Gammaproteobacteria,1XGNC@135618|Methylococcales	135618|Methylococcales	NPTU	ATP-independent chaperone mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_3842439_3	697282.Mettu_2515	3.628e-50	183.0	COG3063@1|root,COG3063@2|Bacteria,1RD9T@1224|Proteobacteria,1S3R3@1236|Gammaproteobacteria,1XF31@135618|Methylococcales	135618|Methylococcales	NU	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
TH1_k127_3884254_2	857087.Metme_3746	9.732e-15	74.0	COG4773@1|root,COG4773@2|Bacteria,1QVK7@1224|Proteobacteria,1T53A@1236|Gammaproteobacteria,1XDUB@135618|Methylococcales	135618|Methylococcales	P	TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
TH1_k127_3884254_1	857087.Metme_3910	5.827e-29	119.0	2EKQ7@1|root,33EDZ@2|Bacteria,1NHK0@1224|Proteobacteria,1SI3D@1236|Gammaproteobacteria,1XFTN@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF2845)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2845
TH1_k127_3884254_0	697282.Mettu_2359	2.021e-140	451.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,1RPYA@1236|Gammaproteobacteria,1XDVA@135618|Methylococcales	135618|Methylococcales	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
TH1_k127_3973648_2	768671.ThimaDRAFT_3161	2.156e-33	132.0	COG4461@1|root,COG4461@2|Bacteria,1R6Q3@1224|Proteobacteria,1S2QD@1236|Gammaproteobacteria,1WZNG@135613|Chromatiales	135613|Chromatiales	G	Lysozyme inhibitor LprI	-	-	-	-	-	-	-	-	-	-	-	-	LprI
TH1_k127_3973648_3	768671.ThimaDRAFT_3178	2.897e-07	59.0	29Y7C@1|root,30K0Y@2|Bacteria,1Q1VV@1224|Proteobacteria,1SSBX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_3973648_0	765911.Thivi_4289	1.255e-40	155.0	COG3103@1|root,COG4991@2|Bacteria	2|Bacteria	T	sh3 domain protein	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	SH3_3
TH1_k127_3973648_1	290315.Clim_2388	2.613e-37	146.0	2E3TX@1|root,32YRB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_3983791_9	903818.KI912268_gene1067	5.77e-17	82.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	int	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
TH1_k127_3983791_5	82654.Pse7367_3858	1.254e-29	120.0	2E5G8@1|root,3307X@2|Bacteria	2|Bacteria	S	Immunity protein 53	-	-	-	-	-	-	-	-	-	-	-	-	Imm53
TH1_k127_3983791_10	118173.KB235914_gene2885	0.0003695	46.0	2FEKE@1|root,346JV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_3983791_6	118173.KB235914_gene2885	9.976e-28	114.0	2FEKE@1|root,346JV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_3983791_3	1162668.LFE_1605	2.133e-54	193.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_7
TH1_k127_3983791_4	1095769.CAHF01000010_gene1338	1.959e-31	125.0	COG4274@1|root,COG4274@2|Bacteria,1RHJ3@1224|Proteobacteria,2VXBZ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
TH1_k127_3983791_8	1144342.PMI40_02307	4.927e-20	93.0	COG1715@1|root,COG1715@2|Bacteria,1Q2VY@1224|Proteobacteria,2VPK0@28216|Betaproteobacteria	28216|Betaproteobacteria	L	restriction endonuclease	-	-	-	ko:K07448	-	-	-	-	ko00000,ko02048	-	-	-	Mrr_N,Mrr_cat
TH1_k127_3983791_7	697282.Mettu_2909	1.047e-23	110.0	COG1607@1|root,COG1607@2|Bacteria,1RAEQ@1224|Proteobacteria,1S3Z2@1236|Gammaproteobacteria,1XF0T@135618|Methylococcales	135618|Methylococcales	I	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TH1_k127_3983791_2	697282.Mettu_1129	1.289e-106	351.0	COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,1S5V1@1236|Gammaproteobacteria,1XDW2@135618|Methylococcales	135618|Methylococcales	S	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K09792	-	-	-	-	ko00000	-	-	-	DsbD_2
TH1_k127_3983791_0	857087.Metme_3757	1.316e-148	475.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,1RMHY@1236|Gammaproteobacteria,1XDT9@135618|Methylococcales	135618|Methylococcales	K	sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
TH1_k127_3983791_1	697282.Mettu_1842	1.998e-120	402.0	COG5607@1|root,COG5607@2|Bacteria,1R5I1@1224|Proteobacteria,1S0QK@1236|Gammaproteobacteria,1XEJ3@135618|Methylococcales	135618|Methylococcales	S	CHAD	-	-	-	-	-	-	-	-	-	-	-	-	CHAD
TH1_k127_4012253_12	1116472.MGMO_124c00110	1.039e-47	173.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1XDWX@135618|Methylococcales	135618|Methylococcales	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
TH1_k127_4012253_11	857087.Metme_0755	1.243e-51	186.0	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,1S61A@1236|Gammaproteobacteria,1XF5X@135618|Methylococcales	135618|Methylococcales	S	Yqey-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
TH1_k127_4012253_13	1116472.MGMO_124c00130	6.659e-37	139.0	COG0828@1|root,COG0828@2|Bacteria,1MZCC@1224|Proteobacteria,1S8QZ@1236|Gammaproteobacteria,1XFID@135618|Methylococcales	135618|Methylococcales	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
TH1_k127_4012253_3	697282.Mettu_1614	1.957e-163	519.0	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,1RN8M@1236|Gammaproteobacteria,1XDPB@135618|Methylococcales	135618|Methylococcales	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
TH1_k127_4012253_8	686340.Metal_3435	2.069e-75	258.0	COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,1RN1J@1236|Gammaproteobacteria,1XEXT@135618|Methylococcales	135618|Methylococcales	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
TH1_k127_4012253_10	1116472.MGMO_124c00170	3.307e-52	186.0	COG1539@1|root,COG1539@2|Bacteria,1MZ8Z@1224|Proteobacteria,1S9B2@1236|Gammaproteobacteria,1XFDQ@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folB	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
TH1_k127_4012253_9	697282.Mettu_1610	1.017e-68	236.0	COG0801@1|root,COG0801@2|Bacteria,1RHNN@1224|Proteobacteria,1S62M@1236|Gammaproteobacteria,1XF75@135618|Methylococcales	135618|Methylococcales	H	PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK	-	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
TH1_k127_4012253_6	697282.Mettu_2628	4.903e-127	414.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,1RMJP@1236|Gammaproteobacteria,1XDJ4@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dusB	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
TH1_k127_4012253_15	697282.Mettu_2627	6.911e-25	108.0	COG2901@1|root,COG2901@2|Bacteria,1N7MJ@1224|Proteobacteria,1SD35@1236|Gammaproteobacteria,1XFS7@135618|Methylococcales	135618|Methylococcales	K	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters	-	-	-	ko:K03557	ko05111,map05111	-	-	-	ko00000,ko00001,ko03000,ko03036,ko03400	-	-	-	HTH_8
TH1_k127_4012253_0	697282.Mettu_2626	4.101e-251	784.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,1XDUC@135618|Methylococcales	135618|Methylococcales	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
TH1_k127_4012253_2	686340.Metal_0050	7.819e-203	638.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,1XDRA@135618|Methylococcales	135618|Methylococcales	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
TH1_k127_4012253_1	686340.Metal_3591	1.2e-219	686.0	28JC0@1|root,2Z96N@2|Bacteria,1R6FS@1224|Proteobacteria,1RR1V@1236|Gammaproteobacteria,1XEM8@135618|Methylococcales	135618|Methylococcales	C	TIGRFAM Ammonia monooxygenase particulate methane monooxygenase, subunit B	-	-	-	ko:K10945	ko00680,ko00910,ko01100,ko01120,ko01200,map00680,map00910,map01100,map01120,map01200	M00174,M00528,M00804	R00148,R09518	RC00173,RC02797	ko00000,ko00001,ko00002	-	-	-	Monooxygenase_B
TH1_k127_4012253_5	697282.Mettu_2427	1.075e-140	448.0	28JPK@1|root,2Z9FM@2|Bacteria,1N0EP@1224|Proteobacteria,1S1WY@1236|Gammaproteobacteria,1XDRM@135618|Methylococcales	135618|Methylococcales	C	TIGRFAM Ammonia monooxygenase particulate methane monooxygenase, subunit A	-	GO:0003674,GO:0003824,GO:0004497,GO:0005575,GO:0008150,GO:0008152,GO:0009987,GO:0015049,GO:0015050,GO:0015947,GO:0016491,GO:0016705,GO:0016709,GO:0032991,GO:0043446,GO:0044237,GO:0055114,GO:0071704,GO:1902494	1.14.18.3,1.14.99.39	ko:K10944	ko00680,ko00910,ko01100,ko01120,ko01200,map00680,map00910,map01100,map01120,map01200	M00174,M00528,M00804	R00148,R09518	RC00173,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	AMO
TH1_k127_4012253_4	697282.Mettu_2426	7.888e-148	469.0	arCOG08699@1|root,2Z9T7@2|Bacteria,1R73C@1224|Proteobacteria,1S05W@1236|Gammaproteobacteria,1XDMD@135618|Methylococcales	135618|Methylococcales	C	methane monooxygenase, subunit C	-	-	-	ko:K10946	ko00680,ko00910,ko01100,ko01120,ko01200,map00680,map00910,map01100,map01120,map01200	M00174,M00528,M00804	R00148,R09518	RC00173,RC02797	ko00000,ko00001,ko00002	-	-	-	AmoC
TH1_k127_4012253_14	686340.Metal_3594	1.259e-34	137.0	2CKZD@1|root,2ZDSM@2|Bacteria,1P7JG@1224|Proteobacteria,1SVVK@1236|Gammaproteobacteria,1XFAP@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_4012253_7	697282.Mettu_2388	1.554e-91	309.0	COG4191@1|root,COG4191@2|Bacteria,1MWR3@1224|Proteobacteria,1RMH4@1236|Gammaproteobacteria,1XDPA@135618|Methylococcales	135618|Methylococcales	T	Histidine kinase	-	-	2.7.13.3	ko:K15011	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c
TH1_k127_402586_0	857087.Metme_0885	2.871e-146	466.0	COG1132@1|root,COG1132@2|Bacteria,1MX5V@1224|Proteobacteria,1RY02@1236|Gammaproteobacteria,1XE77@135618|Methylococcales	135618|Methylococcales	V	(ABC) transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_402586_2	697282.Mettu_1203	2.105e-42	157.0	2E600@1|root,330PC@2|Bacteria,1N9V9@1224|Proteobacteria,1SHAU@1236|Gammaproteobacteria,1XFBV@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_402586_1	697282.Mettu_0023	1.626e-71	246.0	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,1RMHW@1236|Gammaproteobacteria,1XDUH@135618|Methylococcales	135618|Methylococcales	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
TH1_k127_4051917_1	686340.Metal_0789	5.944e-232	722.0	COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,1RNPY@1236|Gammaproteobacteria,1XE67@135618|Methylococcales	135618|Methylococcales	O	Peptidase U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32,Peptidase_U32_C
TH1_k127_4051917_0	1116472.MGMO_176c00100	0.0	1212.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RQMD@1236|Gammaproteobacteria,1XGZF@135618|Methylococcales	135618|Methylococcales	G	Carbohydrate phosphorylase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphorylase
TH1_k127_4051917_2	686340.Metal_2660	1.006e-185	585.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,1RN4D@1236|Gammaproteobacteria,1XE8G@135618|Methylococcales	135618|Methylococcales	C	alcohol dehydrogenase	-	-	-	ko:K13979	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
TH1_k127_4051917_3	697282.Mettu_2381	2.211e-35	135.0	COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,1RPSM@1236|Gammaproteobacteria,1XES9@135618|Methylococcales	135618|Methylococcales	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
TH1_k127_4093522_2	697282.Mettu_1003	3.193e-30	121.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,1RME0@1236|Gammaproteobacteria,1XE5M@135618|Methylococcales	135618|Methylococcales	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TH1_k127_4093522_0	697282.Mettu_1004	0.0	1387.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1XETD@135618|Methylococcales	135618|Methylococcales	C	2-oxoglutarate dehydrogenase, E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
TH1_k127_4093522_1	697282.Mettu_1006	6.786e-31	126.0	COG2916@1|root,COG2916@2|Bacteria,1N801@1224|Proteobacteria,1SF10@1236|Gammaproteobacteria,1XFFV@135618|Methylococcales	135618|Methylococcales	S	Domain in histone-like proteins of HNS family	-	-	-	ko:K03746	-	-	-	-	ko00000,ko03036,ko03400	-	-	-	Histone_HNS
TH1_k127_4093522_5	1283300.ATXB01000002_gene2880	3.526e-07	53.0	2AW8E@1|root,31N3P@2|Bacteria,1QJV8@1224|Proteobacteria,1THWU@1236|Gammaproteobacteria,1XFWT@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_4093522_3	243233.MCA1485	1.147e-23	102.0	COG1912@1|root,COG1912@2|Bacteria,1MV99@1224|Proteobacteria,1RQES@1236|Gammaproteobacteria,1XF1I@135618|Methylococcales	135618|Methylococcales	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
TH1_k127_410202_2	697282.Mettu_0407	2.236e-23	110.0	COG3330@1|root,COG3330@2|Bacteria,1P8BB@1224|Proteobacteria,1SV0Y@1236|Gammaproteobacteria,1XGM5@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF4912)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4912
TH1_k127_410202_0	697282.Mettu_0408	5.981e-249	778.0	COG1543@1|root,COG1543@2|Bacteria,1R5SN@1224|Proteobacteria,1S1IY@1236|Gammaproteobacteria,1XEJV@135618|Methylococcales	135618|Methylococcales	G	Belongs to the glycosyl hydrolase 57 family	-	-	2.4.1.18	ko:K16149	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000	-	GH57	-	DUF1957,Glyco_hydro_57
TH1_k127_410202_1	243233.MCA2606	8.288e-131	432.0	COG0297@1|root,COG0297@2|Bacteria,1P7F2@1224|Proteobacteria,1RZVJ@1236|Gammaproteobacteria,1XG73@135618|Methylococcales	135618|Methylococcales	G	Starch synthase catalytic domain	-	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009011,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046527,GO:0055114,GO:0071704,GO:1901576	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
TH1_k127_4104113_3	697282.Mettu_2079	2.74e-97	322.0	COG0807@1|root,COG0807@2|Bacteria,1MWZR@1224|Proteobacteria,1RMFX@1236|Gammaproteobacteria,1XDXJ@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	ribA	-	-	-	-	-	-	-	-	-	-	-	GTP_cyclohydro2
TH1_k127_4104113_4	1049564.TevJSym_aa01140	1.214e-48	180.0	COG2062@1|root,COG2062@2|Bacteria,1N0FX@1224|Proteobacteria,1S2AY@1236|Gammaproteobacteria,1J762@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	Phosphoglycerate mutase family	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
TH1_k127_4104113_1	697282.Mettu_2451	1.49e-286	884.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,1RNH8@1236|Gammaproteobacteria,1XDU2@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
TH1_k127_4104113_2	857087.Metme_3440	4.912e-117	386.0	COG0053@1|root,COG0053@2|Bacteria,1MVH8@1224|Proteobacteria,1RQ3E@1236|Gammaproteobacteria,1XEIQ@135618|Methylococcales	135618|Methylococcales	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
TH1_k127_4104113_0	1116472.MGMO_53c00870	0.0	1051.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,1XDJY@135618|Methylococcales	135618|Methylococcales	E	Peptidase family M3	prlC	-	3.4.24.70	ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
TH1_k127_4139614_3	686340.Metal_1393	2.261e-138	446.0	COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,1RMJW@1236|Gammaproteobacteria,1XDQU@135618|Methylococcales	135618|Methylococcales	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
TH1_k127_4139614_0	857087.Metme_2910	7.646e-264	826.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,1RN76@1236|Gammaproteobacteria,1XEA6@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
TH1_k127_4139614_4	857087.Metme_2911	5.343e-90	301.0	COG0363@1|root,COG0363@2|Bacteria,1R5K6@1224|Proteobacteria,1S11C@1236|Gammaproteobacteria,1XE7W@135618|Methylococcales	135618|Methylococcales	G	6-phosphogluconolactonase	-	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
TH1_k127_4139614_2	765913.ThidrDRAFT_3275	7.105e-179	568.0	COG1449@1|root,COG1449@2|Bacteria,1R5KI@1224|Proteobacteria,1S0ID@1236|Gammaproteobacteria,1WXJ4@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
TH1_k127_4139614_1	243233.MCA2119	6.027e-238	743.0	COG1449@1|root,COG1449@2|Bacteria,1R3Z3@1224|Proteobacteria,1RNRC@1236|Gammaproteobacteria,1XG1U@135618|Methylococcales	135618|Methylococcales	G	Glycosyl hydrolase family 57	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
TH1_k127_4139614_5	697282.Mettu_2848	1.841e-60	212.0	2DN5Z@1|root,32VR7@2|Bacteria,1RI34@1224|Proteobacteria,1T3FH@1236|Gammaproteobacteria,1XDWT@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF2490)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2490
TH1_k127_4139614_6	1116472.MGMO_85c00160	3.228e-38	145.0	2DN5Z@1|root,32VR7@2|Bacteria,1RI34@1224|Proteobacteria,1T3FH@1236|Gammaproteobacteria,1XDWT@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF2490)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2490
TH1_k127_4139614_7	857087.Metme_0818	8.997e-18	87.0	COG3416@1|root,COG3416@2|Bacteria,1PWXI@1224|Proteobacteria,1SEV4@1236|Gammaproteobacteria,1XGIU@135618|Methylococcales	135618|Methylococcales	S	Uncharacterized protein conserved in bacteria (DUF2076)	-	-	-	ko:K09945	-	-	-	-	ko00000	-	-	-	DUF2076
TH1_k127_4139614_8	686340.Metal_3068	3.361e-16	81.0	2DQ5D@1|root,334TW@2|Bacteria	2|Bacteria	S	Small metal-binding protein	smbP	-	-	-	-	-	-	-	-	-	-	-	SMBP
TH1_k127_4143164_1	697282.Mettu_2474	1.244e-130	422.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,1RMCP@1236|Gammaproteobacteria,1XEGZ@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	-	1.3.5.2	ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
TH1_k127_4143164_0	697282.Mettu_2473	1.551e-204	644.0	COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,1RPJF@1236|Gammaproteobacteria,1XDTZ@135618|Methylococcales	135618|Methylococcales	S	modulator of DNA gyrase	pmbA	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
TH1_k127_415202_0	697282.Mettu_0224	3.196e-173	548.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1XEIG@135618|Methylococcales	135618|Methylococcales	P	ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
TH1_k127_415202_1	243233.MCA0851	1.649e-35	142.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RQ2G@1236|Gammaproteobacteria,1XDIS@135618|Methylococcales	135618|Methylococcales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
TH1_k127_4159443_0	1288494.EBAPG3_19700	6.559e-98	332.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2VN8I@28216|Betaproteobacteria,372VF@32003|Nitrosomonadales	28216|Betaproteobacteria	C	PFAM FAD dependent oxidoreductase	glpD	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
TH1_k127_4159443_1	765420.OSCT_2071	9.172e-12	66.0	COG2114@1|root,COG2202@1|root,COG2114@2|Bacteria,COG2202@2|Bacteria	2|Bacteria	T	Pas domain	-	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0035556,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0140096,GO:1901564	-	ko:K03320,ko:K11525	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.11	-	-	Guanylate_cyc,PAS_9
TH1_k127_4189732_0	1116472.MGMO_16c00020	0.0	2085.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,1RMW9@1236|Gammaproteobacteria,1XDIT@135618|Methylococcales	135618|Methylococcales	G	Glycosyl hydrolase 36 superfamily, catalytic domain	-	-	-	ko:K13688	-	-	-	-	ko00000,ko01000,ko01003	-	GH94,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
TH1_k127_4189732_4	449447.MAE_29560	0.0001812	47.0	2E3KF@1|root,32YIQ@2|Bacteria,1GFX6@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_4189732_3	1502770.JQMG01000001_gene136	2.591e-15	76.0	2EFZF@1|root,339RM@2|Bacteria,1NH6S@1224|Proteobacteria,2VYEK@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_4189732_2	697282.Mettu_0586	3.722e-28	116.0	2DNSI@1|root,32YXC@2|Bacteria,1N7K2@1224|Proteobacteria,1SD17@1236|Gammaproteobacteria,1XGPY@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_4189732_1	697282.Mettu_1050	8.493e-114	379.0	28MV6@1|root,2ZB2T@2|Bacteria,1R710@1224|Proteobacteria,1SMZR@1236|Gammaproteobacteria,1XEVI@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_4199010_0	697282.Mettu_0634	4.953e-270	840.0	COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria,1MWF8@1224|Proteobacteria,1S08E@1236|Gammaproteobacteria,1XDJZ@135618|Methylococcales	135618|Methylococcales	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_17,Glyco_tranf_2_3
TH1_k127_422813_0	697282.Mettu_2684	1.698e-125	405.0	COG1192@1|root,COG1192@2|Bacteria,1MVEZ@1224|Proteobacteria,1RPWA@1236|Gammaproteobacteria,1XDKA@135618|Methylococcales	135618|Methylococcales	D	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
TH1_k127_422813_2	717772.THIAE_08960	3.861e-66	233.0	COG3751@1|root,COG3751@2|Bacteria,1RD3H@1224|Proteobacteria,1S40I@1236|Gammaproteobacteria,46161@72273|Thiotrichales	72273|Thiotrichales	O	2OG-Fe(II) oxygenase	-	-	-	ko:K07394	-	-	-	-	ko00000	-	-	-	2OG-FeII_Oxy_3,2OG-FeII_Oxy_4
TH1_k127_422813_1	697282.Mettu_0117	2.042e-104	346.0	COG3217@1|root,COG3217@2|Bacteria,1MXN2@1224|Proteobacteria,1RMN7@1236|Gammaproteobacteria,1XEKB@135618|Methylococcales	135618|Methylococcales	S	MOSC N-terminal beta barrel domain	-	-	-	ko:K07140	-	-	-	-	ko00000	-	-	-	MOSC,MOSC_N
TH1_k127_422813_3	686340.Metal_1876	1.386e-44	164.0	COG2834@1|root,COG2834@2|Bacteria,1PXDV@1224|Proteobacteria,1S9FW@1236|Gammaproteobacteria,1XDIN@135618|Methylococcales	135618|Methylococcales	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
TH1_k127_4241147_4	697282.Mettu_1210	2.973e-44	163.0	2DP2V@1|root,330AH@2|Bacteria,1R3EE@1224|Proteobacteria,1T670@1236|Gammaproteobacteria,1XGE6@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF3455)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3455
TH1_k127_4241147_2	935863.AWZR01000001_gene1706	2.36e-75	269.0	COG1819@1|root,COG1819@2|Bacteria,1MVI7@1224|Proteobacteria,1S57B@1236|Gammaproteobacteria,1X5IY@135614|Xanthomonadales	135614|Xanthomonadales	CG	Glycosyl transferases, related to UDP-glucuronosyltransferase	ugt	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_28,UDPGT
TH1_k127_4241147_5	877418.ATWV01000003_gene650	1.436e-40	168.0	COG2114@1|root,COG2114@2|Bacteria,2J5GP@203691|Spirochaetes	2|Bacteria	T	guanylate cyclase catalytic domain	cyaA	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
TH1_k127_4241147_1	1121374.KB891585_gene2415	1.916e-76	273.0	COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,1RPEZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2206 HD-GYP domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD,HD_5
TH1_k127_4241147_3	1116472.MGMO_175c00100	8.312e-71	245.0	COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,1S3QU@1236|Gammaproteobacteria,1XECD@135618|Methylococcales	135618|Methylococcales	E	GDSL-like Lipase/Acylhydrolase family	-	-	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	Lipase_GDSL_2
TH1_k127_4241147_0	697282.Mettu_2349	2.504e-93	312.0	COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,1RMG1@1236|Gammaproteobacteria,1XE9K@135618|Methylococcales	135618|Methylococcales	Q	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TH1_k127_4292018_3	697282.Mettu_3847	1.393e-46	170.0	COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,1S3T3@1236|Gammaproteobacteria,1XF26@135618|Methylococcales	135618|Methylococcales	S	PFAM Haloacid dehalogenase-like hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
TH1_k127_4292018_1	1116472.MGMO_126c00120	8.997e-137	441.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNYW@1236|Gammaproteobacteria,1XE69@135618|Methylococcales	135618|Methylococcales	OU	signal peptide peptidase SppA	-	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
TH1_k127_4292018_4	1116472.MGMO_126c00110	3.179e-06	53.0	2DETF@1|root,2ZP6V@2|Bacteria,1PBEN@1224|Proteobacteria,1SU70@1236|Gammaproteobacteria,1XFPA@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_4292018_2	686340.Metal_0249	6.533e-112	365.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RMWT@1236|Gammaproteobacteria,1XDXZ@135618|Methylococcales	135618|Methylococcales	K	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TH1_k127_4292018_0	697282.Mettu_3843	1.782e-161	520.0	COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,1T213@1236|Gammaproteobacteria,1XE88@135618|Methylococcales	135618|Methylococcales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
TH1_k127_4300854_4	697282.Mettu_0654	1.282e-85	286.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1XG7M@135618|Methylococcales	135618|Methylococcales	C	Aconitase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aconitase,Aconitase_C
TH1_k127_4300854_1	1005048.CFU_1722	9.423e-109	358.0	COG1023@1|root,COG1023@2|Bacteria,1QU14@1224|Proteobacteria,2WH34@28216|Betaproteobacteria	28216|Betaproteobacteria	G	6-phosphogluconate dehydrogenase	-	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
TH1_k127_4300854_0	743299.Acife_0694	3.056e-256	796.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,1RN76@1236|Gammaproteobacteria,2NBW1@225057|Acidithiobacillales	1236|Gammaproteobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
TH1_k127_4300854_3	580332.Slit_0299	1.598e-101	337.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VQEJ@28216|Betaproteobacteria,44WFQ@713636|Nitrosomonadales	28216|Betaproteobacteria	KT	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD_5
TH1_k127_4300854_5	697282.Mettu_0226	3.023e-70	245.0	COG0398@1|root,COG0398@2|Bacteria,1QJNQ@1224|Proteobacteria,1THPM@1236|Gammaproteobacteria,1XF7E@135618|Methylococcales	135618|Methylococcales	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TH1_k127_4300854_7	502025.Hoch_5330	4.413e-16	92.0	COG1404@1|root,COG4935@1|root,COG1404@2|Bacteria,COG4935@2|Bacteria,1MU3S@1224|Proteobacteria,42Q3Z@68525|delta/epsilon subdivisions,2WJPC@28221|Deltaproteobacteria,2YUCY@29|Myxococcales	28221|Deltaproteobacteria	O	PFAM peptidase S8 and S53 subtilisin kexin sedolisin	-	-	3.4.21.66	ko:K08651	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	Big_2,CUB,Peptidase_S8
TH1_k127_4300854_6	1519464.HY22_11255	1.75e-64	231.0	COG1132@1|root,COG1132@2|Bacteria	2|Bacteria	V	(ABC) transporter	-	-	-	ko:K02471,ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.203.11,3.A.1.203.4,3.A.1.21	-	-	ABC_membrane,ABC_tran
TH1_k127_4300854_2	686340.Metal_1480	4.087e-108	367.0	COG1538@1|root,COG1538@2|Bacteria,1QITP@1224|Proteobacteria,1TGP9@1236|Gammaproteobacteria,1XG42@135618|Methylococcales	135618|Methylococcales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TH1_k127_4363332_7	243233.MCA2868	5.103e-66	236.0	COG1821@1|root,COG1821@2|Bacteria,1RBY6@1224|Proteobacteria,1S7TK@1236|Gammaproteobacteria,1XGZ7@135618|Methylococcales	135618|Methylococcales	S	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3
TH1_k127_4363332_11	323261.Noc_1299	2.248e-51	188.0	COG3012@1|root,COG3012@2|Bacteria,1MZZK@1224|Proteobacteria,1S9FV@1236|Gammaproteobacteria,1WYWP@135613|Chromatiales	135613|Chromatiales	S	Belongs to the UPF0225 family	-	-	-	ko:K09858	-	-	-	-	ko00000	-	-	-	SEC-C
TH1_k127_4363332_10	686340.Metal_1898	1.103e-55	201.0	COG0242@1|root,COG0242@2|Bacteria,1R9XK@1224|Proteobacteria,1S672@1236|Gammaproteobacteria,1XF96@135618|Methylococcales	135618|Methylococcales	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	-	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
TH1_k127_4363332_0	697282.Mettu_3001	1.118e-220	709.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,1RMW6@1236|Gammaproteobacteria,1XDUM@135618|Methylococcales	135618|Methylococcales	S	Competence protein ComEC Rec2	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
TH1_k127_4363332_9	243233.MCA2626	6.863e-57	215.0	COG3216@1|root,COG3216@2|Bacteria,1RGV6@1224|Proteobacteria,1S682@1236|Gammaproteobacteria,1XF7K@135618|Methylococcales	135618|Methylococcales	S	Uncharacterized protein conserved in bacteria (DUF2062)	-	-	-	ko:K09928	-	-	-	-	ko00000	-	-	-	DUF2062
TH1_k127_4363332_3	1123367.C666_01500	8.226e-127	408.0	COG0580@1|root,COG0580@2|Bacteria,1MXTJ@1224|Proteobacteria,2VK6T@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity	aqpZ	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
TH1_k127_4363332_4	1283300.ATXB01000001_gene1477	7.155e-87	292.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,1RMWK@1236|Gammaproteobacteria,1XDWU@135618|Methylococcales	135618|Methylococcales	V	Part of the ABC transporter complex LolCDE involved in the translocation of	lolD	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033036,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
TH1_k127_4363332_2	697282.Mettu_3004	9.262e-200	631.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,1XE02@135618|Methylococcales	135618|Methylococcales	M	TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
TH1_k127_4363332_6	686340.Metal_1310	1.603e-66	228.0	COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,1S4H7@1236|Gammaproteobacteria,1XF3C@135618|Methylococcales	135618|Methylococcales	K	Belongs to the Fur family	fur	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
TH1_k127_4363332_12	857087.Metme_2237	9.71e-51	190.0	COG2913@1|root,COG2913@2|Bacteria,1N6YW@1224|Proteobacteria,1SCTT@1236|Gammaproteobacteria,1XF8G@135618|Methylococcales	135618|Methylococcales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamE	-	-	ko:K06186	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	SmpA_OmlA
TH1_k127_4363332_13	349124.Hhal_1483	1.316e-27	114.0	COG2914@1|root,COG2914@2|Bacteria,1MZCH@1224|Proteobacteria,1SCHG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the UPF0125 (RnfH) family	yfjF	-	-	ko:K09801	-	-	-	-	ko00000	-	-	-	Ub-RnfH
TH1_k127_4363332_8	1116472.MGMO_101c00070	2.785e-63	223.0	COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,1S61C@1236|Gammaproteobacteria,1XF3E@135618|Methylococcales	135618|Methylococcales	I	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
TH1_k127_4363332_1	697282.Mettu_3014	1.562e-210	662.0	COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,1RPCT@1236|Gammaproteobacteria,1XE0D@135618|Methylococcales	135618|Methylococcales	U	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
TH1_k127_4363332_5	686340.Metal_1316	1.059e-78	265.0	COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,1S3PT@1236|Gammaproteobacteria,1XF0N@135618|Methylococcales	135618|Methylococcales	J	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
TH1_k127_4391196_1	697282.Mettu_2732	2.117e-99	328.0	COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,1S21S@1236|Gammaproteobacteria,1XET0@135618|Methylococcales	135618|Methylococcales	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
TH1_k127_4391196_2	686340.Metal_1428	1.584e-18	89.0	COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,1SD8H@1236|Gammaproteobacteria,1XFRY@135618|Methylococcales	135618|Methylococcales	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsB	-	-	ko:K05589	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
TH1_k127_4391196_0	686340.Metal_1427	1.511e-165	524.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,1XDS1@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
TH1_k127_4430908_2	857087.Metme_0336	3.309e-133	434.0	COG0304@1|root,COG0304@2|Bacteria,1N91E@1224|Proteobacteria,1RMPP@1236|Gammaproteobacteria,1XDS2@135618|Methylococcales	135618|Methylococcales	IQ	Belongs to the beta-ketoacyl-ACP synthases family	-	-	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TH1_k127_4430908_3	1283300.ATXB01000002_gene2854	8.509e-41	160.0	COG0304@1|root,COG0304@2|Bacteria,1N91E@1224|Proteobacteria,1RMPP@1236|Gammaproteobacteria,1XDS2@135618|Methylococcales	135618|Methylococcales	IQ	Belongs to the beta-ketoacyl-ACP synthases family	-	-	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TH1_k127_4430908_1	857087.Metme_0333	4.272e-144	466.0	COG0644@1|root,COG0644@2|Bacteria,1MZVI@1224|Proteobacteria,1RMNS@1236|Gammaproteobacteria,1XDKP@135618|Methylococcales	135618|Methylococcales	C	Tryptophan halogenase	-	-	-	-	-	-	-	-	-	-	-	-	Trp_halogenase
TH1_k127_4430908_4	1266909.AUAG01000004_gene2148	4.314e-23	105.0	2EAP9@1|root,334RQ@2|Bacteria,1NDHV@1224|Proteobacteria,1SD8V@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_4430908_0	857087.Metme_4190	2.06e-160	516.0	COG0644@1|root,COG0644@2|Bacteria,1MZVI@1224|Proteobacteria,1RMNS@1236|Gammaproteobacteria,1XG92@135618|Methylococcales	135618|Methylococcales	C	Lycopene cyclase protein	-	-	-	-	-	-	-	-	-	-	-	-	Trp_halogenase
TH1_k127_4430908_5	857087.Metme_3330	1.889e-15	79.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,1XDSD@135618|Methylococcales	135618|Methylococcales	U	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
TH1_k127_444166_1	686340.Metal_3811	2.523e-153	487.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,1RNDC@1236|Gammaproteobacteria,1XDR0@135618|Methylococcales	135618|Methylococcales	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
TH1_k127_444166_0	1283300.ATXB01000001_gene1466	2.509e-186	601.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TH1_k127_444166_3	697282.Mettu_0040	1.266e-56	201.0	COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,1S61I@1236|Gammaproteobacteria,1XF4C@135618|Methylococcales	135618|Methylococcales	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	-	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
TH1_k127_444166_2	697282.Mettu_0015	6.742e-77	266.0	COG1525@1|root,COG1525@2|Bacteria,1RKRQ@1224|Proteobacteria,1S5D6@1236|Gammaproteobacteria,1XDMG@135618|Methylococcales	135618|Methylococcales	L	PFAM Staphylococcal nuclease	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124,SNase
TH1_k127_4459050_0	697282.Mettu_3921	3.97e-215	680.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1XEFK@135618|Methylococcales	135618|Methylococcales	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	3HCDH,3HCDH_N,ECH_1
TH1_k127_4459050_1	598467.BrE312_0922	1.316e-13	74.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	acyl-CoA dehydrogenase	fadE	GO:0003674,GO:0003824,GO:0003995,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016491,GO:0016627,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575	-	ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	iSbBS512_1146.SbBS512_E0217	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974
TH1_k127_4467949_4	1116472.MGMO_8c00190	5.422e-59	208.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,1RMIA@1236|Gammaproteobacteria,1XDWV@135618|Methylococcales	135618|Methylococcales	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_5
TH1_k127_4467949_7	1117314.PCIT_05764	4.037e-07	55.0	2DP8T@1|root,3311X@2|Bacteria,1NCQ9@1224|Proteobacteria,1SFHB@1236|Gammaproteobacteria,2Q3DV@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_4467949_5	697282.Mettu_0760	2.091e-25	109.0	2B5JV@1|root,31YET@2|Bacteria,1QK4K@1224|Proteobacteria,1TI7N@1236|Gammaproteobacteria,1XGQ7@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_4467949_0	697282.Mettu_0761	0.0	1173.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1XE41@135618|Methylococcales	135618|Methylococcales	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008773,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0070569,GO:0071704,GO:0140096,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
TH1_k127_4467949_1	686340.Metal_2412	1.288e-140	451.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,1RMHN@1236|Gammaproteobacteria,1XDN3@135618|Methylococcales	135618|Methylococcales	J	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
TH1_k127_4467949_2	1116472.MGMO_105c00750	2.379e-136	436.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,1RN0Z@1236|Gammaproteobacteria,1XDV8@135618|Methylococcales	135618|Methylococcales	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
TH1_k127_4467949_3	697282.Mettu_0764	1.298e-130	422.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,1RPBJ@1236|Gammaproteobacteria,1XE51@135618|Methylococcales	135618|Methylococcales	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
TH1_k127_4467949_6	857087.Metme_1636	3.548e-24	104.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,1RMHX@1236|Gammaproteobacteria,1XDK8@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
TH1_k127_4518788_3	1116472.MGMO_116c00160	3.38e-33	132.0	COG1362@1|root,COG1362@2|Bacteria,1NT1D@1224|Proteobacteria,1RPHR@1236|Gammaproteobacteria,1XECI@135618|Methylococcales	135618|Methylococcales	E	M18 family aminopeptidase	-	-	3.4.11.21	ko:K01267	-	-	-	-	ko00000,ko01000,ko01002,ko04131	-	-	-	Peptidase_M18
TH1_k127_4518788_1	686340.Metal_0847	1.839e-68	234.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,1S5WI@1236|Gammaproteobacteria,1XFDJ@135618|Methylococcales	135618|Methylococcales	C	HAMAP Peptide methionine sulfoxide reductase msrB	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
TH1_k127_4518788_2	1121403.AUCV01000033_gene3627	1.204e-65	228.0	COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,42RVP@68525|delta/epsilon subdivisions,2WNCX@28221|Deltaproteobacteria,2MJVF@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM Appr-1-p processing domain protein	ymdB	-	-	-	-	-	-	-	-	-	-	-	Macro
TH1_k127_4518788_4	1116472.MGMO_41c00230	1.036e-22	102.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XEM2@135618|Methylococcales	1236|Gammaproteobacteria	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region	-	-	2.7.13.3	ko:K20974	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	CHASE8,HAMP,HATPase_c,HisKA,Hpt,Response_reg
TH1_k127_4518788_0	338966.Ppro_2997	3.615e-114	386.0	COG3322@1|root,COG5001@1|root,COG3322@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria,43U61@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	CHASE4 domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,EAL,GGDEF,PAS,PAS_4,PAS_9,dCache_1
TH1_k127_4533991_2	686340.Metal_2840	1.599e-38	149.0	COG1917@1|root,COG1917@2|Bacteria,1NG18@1224|Proteobacteria,1SCCP@1236|Gammaproteobacteria,1XFMT@135618|Methylococcales	135618|Methylococcales	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TH1_k127_4533991_1	697282.Mettu_1200	3.622e-60	211.0	COG0590@1|root,COG0590@2|Bacteria,1RHM4@1224|Proteobacteria,1S4RE@1236|Gammaproteobacteria,1XF6P@135618|Methylococcales	135618|Methylococcales	FJ	deaminase zinc-binding	-	-	-	-	-	-	-	-	-	-	-	-	dCMP_cyt_deam_1
TH1_k127_4533991_0	686340.Metal_0832	4.496e-141	451.0	COG1897@1|root,COG1897@2|Bacteria,1MV64@1224|Proteobacteria,1RM7T@1236|Gammaproteobacteria,1XE2G@135618|Methylococcales	135618|Methylococcales	E	Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine	metAS	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0008899,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016750,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.46	ko:K00651	ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230	M00017	R01777	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	HTS
TH1_k127_4566743_0	243233.MCA0061	2.097e-141	467.0	COG3267@1|root,COG3409@1|root,COG3267@2|Bacteria,COG3409@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,1XERT@135618|Methylococcales	135618|Methylococcales	U	SMART ATPase, AAA type, core	-	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1
TH1_k127_4566743_1	589865.DaAHT2_0463	7.122e-11	72.0	COG5373@1|root,COG5373@2|Bacteria,1QZY0@1224|Proteobacteria,42XBF@68525|delta/epsilon subdivisions,2WSP1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Type II secretion system protein B	-	-	-	ko:K02451	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	T2SSB
TH1_k127_4582299_1	1123256.KB907934_gene2360	4.651e-190	598.0	COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,1RMRA@1236|Gammaproteobacteria,1X46F@135614|Xanthomonadales	135614|Xanthomonadales	V	Type I restriction-modification system	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
TH1_k127_4582299_4	713587.THITH_03360	2.067e-38	147.0	COG1487@1|root,COG1487@2|Bacteria,1MZZ9@1224|Proteobacteria,1SDG0@1236|Gammaproteobacteria,1X1QS@135613|Chromatiales	135613|Chromatiales	S	nucleic acid-binding protein contains PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TH1_k127_4582299_6	631362.Thi970DRAFT_03454	5.135e-23	99.0	COG5450@1|root,COG5450@2|Bacteria,1N75T@1224|Proteobacteria,1SD7P@1236|Gammaproteobacteria,1WZRQ@135613|Chromatiales	135613|Chromatiales	K	Bacterial antitoxin of type II TA system, VapB	-	-	-	-	-	-	-	-	-	-	-	-	VapB_antitoxin
TH1_k127_4582299_2	686340.Metal_0785	1.003e-134	440.0	28HTA@1|root,2Z806@2|Bacteria,1R7QM@1224|Proteobacteria,1RSIK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_4582299_3	743299.Acife_3243	2.93e-40	153.0	2DPU2@1|root,333DK@2|Bacteria,1NCKZ@1224|Proteobacteria,1SEQE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TH1_k127_4582299_5	765911.Thivi_4135	7.97e-24	102.0	2EAHN@1|root,334KU@2|Bacteria,1NAT6@1224|Proteobacteria,1SD2M@1236|Gammaproteobacteria,1X202@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_4582299_0	857087.Metme_3185	1.166e-264	823.0	COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,1RMPG@1236|Gammaproteobacteria,1XE0Q@135618|Methylococcales	135618|Methylococcales	L	DNA helicase	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind
TH1_k127_4597897_2	768671.ThimaDRAFT_3266	1.547e-113	372.0	COG0664@1|root,COG2066@1|root,COG0664@2|Bacteria,COG2066@2|Bacteria,1MWB5@1224|Proteobacteria,1RMY9@1236|Gammaproteobacteria,1WYNM@135613|Chromatiales	135613|Chromatiales	E	Belongs to the glutaminase family	glsA	-	3.5.1.2	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	-	R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Glutaminase
TH1_k127_4597897_0	697282.Mettu_2490	0.0	1133.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,1RP1F@1236|Gammaproteobacteria,1XE5Y@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
TH1_k127_4597897_1	1116472.MGMO_114c00080	3.676e-303	935.0	COG0433@1|root,COG0433@2|Bacteria,1MUSH@1224|Proteobacteria,1RXZ7@1236|Gammaproteobacteria,1XE3M@135618|Methylococcales	135618|Methylococcales	S	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853,DUF87
TH1_k127_4597897_3	406818.XBJ1_3083	5.154e-72	244.0	COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,1RQUC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Aldolase	fbaA	GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016830,GO:0016832,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	iZ_1308.Z4263	F_bP_aldolase
TH1_k127_4613760_0	686340.Metal_0843	5.134e-154	494.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1XENK@135618|Methylococcales	135618|Methylococcales	M	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
TH1_k127_4613760_1	686340.Metal_0842	6.147e-58	209.0	COG2091@1|root,COG2091@2|Bacteria,1MZHC@1224|Proteobacteria,1SCGA@1236|Gammaproteobacteria,1XFGV@135618|Methylococcales	135618|Methylococcales	H	Belongs to the P-Pant transferase superfamily	-	-	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
TH1_k127_4613760_2	314278.NB231_12234	1.261e-06	59.0	COG1073@1|root,COG1073@2|Bacteria,1R8S6@1224|Proteobacteria,1S4WS@1236|Gammaproteobacteria,1WYQJ@135613|Chromatiales	135613|Chromatiales	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_461921_2	697282.Mettu_1997	5.384e-49	177.0	COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,1S5VH@1236|Gammaproteobacteria,1XF82@135618|Methylococcales	135618|Methylococcales	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	-	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
TH1_k127_461921_0	857087.Metme_4430	6.597e-143	456.0	COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,1RPYV@1236|Gammaproteobacteria,1XEA2@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
TH1_k127_461921_1	686340.Metal_0485	7.328e-127	409.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,1XEIT@135618|Methylococcales	135618|Methylococcales	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
TH1_k127_461921_3	697282.Mettu_1604	3.482e-09	59.0	COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R9Q1@1224|Proteobacteria,1RSKD@1236|Gammaproteobacteria,1XEBR@135618|Methylococcales	135618|Methylococcales	PT	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,cNMP_binding
TH1_k127_4668211_1	697282.Mettu_0985	7.494e-141	455.0	COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,1RPHQ@1236|Gammaproteobacteria,1XE1V@135618|Methylococcales	135618|Methylococcales	J	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue	prmB	-	2.1.1.298	ko:K07320	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03009	-	-	-	MTS
TH1_k127_4668211_0	686340.Metal_0976	1.107e-202	634.0	COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,1RMQS@1236|Gammaproteobacteria,1XDME@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
TH1_k127_4668211_2	697282.Mettu_0987	3.518e-123	403.0	COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,1RPBT@1236|Gammaproteobacteria,1XDJR@135618|Methylococcales	135618|Methylococcales	EGP	Nucleoside H+ symporter	-	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
TH1_k127_4672544_0	686340.Metal_3539	8.951e-142	456.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,1RME9@1236|Gammaproteobacteria,1XENN@135618|Methylococcales	135618|Methylococcales	P	transporter of a GTP-driven Fe(2 ) uptake system	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
TH1_k127_4672544_2	686340.Metal_3538	4.853e-30	121.0	COG1918@1|root,COG1918@2|Bacteria,1N8ZJ@1224|Proteobacteria,1S9TZ@1236|Gammaproteobacteria,1XFKX@135618|Methylococcales	135618|Methylococcales	P	PFAM Ferrous iron transporter, FeoA subunit	-	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
TH1_k127_4672544_1	426114.THI_1130	7.983e-43	159.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2VJUZ@28216|Betaproteobacteria,1KKDD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EQ	Hydantoinase/oxoprolinase N-terminal region	oplaH	-	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
TH1_k127_4712002_3	1116472.MGMO_185c00030	6.82e-05	47.0	COG3404@1|root,COG3404@2|Bacteria,1R781@1224|Proteobacteria,1SFG9@1236|Gammaproteobacteria,1XEUC@135618|Methylococcales	135618|Methylococcales	E	Formiminotransferase-cyclodeaminase	fchA	-	-	-	-	-	-	-	-	-	-	-	FTCD_C
TH1_k127_4712002_0	697282.Mettu_0422	2.84e-239	747.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,1RP5K@1236|Gammaproteobacteria,1XDTS@135618|Methylococcales	135618|Methylococcales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
TH1_k127_4712002_1	857087.Metme_3951	5.895e-84	283.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1S222@1236|Gammaproteobacteria,1XDKY@135618|Methylococcales	135618|Methylococcales	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
TH1_k127_4712002_2	857087.Metme_0637	3.062e-13	70.0	COG1993@1|root,COG1993@2|Bacteria,1N8TP@1224|Proteobacteria,1SDYH@1236|Gammaproteobacteria,1XFJY@135618|Methylococcales	135618|Methylococcales	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
TH1_k127_4712114_4	1116472.MGMO_93c00020	1.261e-84	283.0	COG1943@1|root,COG1943@2|Bacteria,1RCWW@1224|Proteobacteria,1S3ZJ@1236|Gammaproteobacteria,1XG1C@135618|Methylococcales	135618|Methylococcales	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
TH1_k127_4712114_0	1116472.MGMO_6c00180	1.007e-159	509.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,1RR68@1236|Gammaproteobacteria,1XEUY@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
TH1_k127_4712114_2	697282.Mettu_4307	1.238e-109	365.0	COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,1RVRF@1236|Gammaproteobacteria,1XESY@135618|Methylococcales	135618|Methylococcales	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp,OmpA
TH1_k127_4712114_5	686340.Metal_0800	2.391e-45	167.0	2AWKJ@1|root,31NHB@2|Bacteria,1QK85@1224|Proteobacteria,1TIBJ@1236|Gammaproteobacteria,1XGX7@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_4712114_3	686340.Metal_0799	4.519e-109	355.0	COG2010@1|root,COG2010@2|Bacteria,1RDSI@1224|Proteobacteria,1S4BC@1236|Gammaproteobacteria,1XDVB@135618|Methylococcales	135618|Methylococcales	C	Cytochrome c	-	-	-	ko:K02305	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002	3.D.4.10	-	-	Cytochrom_C
TH1_k127_4712114_1	686340.Metal_0798	1.198e-125	404.0	COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,1RQ01@1236|Gammaproteobacteria,1XE9J@135618|Methylococcales	135618|Methylococcales	P	Cytochrome C and Quinol oxidase polypeptide I	-	-	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
TH1_k127_4724286_1	243233.MCA1141	1.945e-71	244.0	COG0650@1|root,COG0650@2|Bacteria,1MXV5@1224|Proteobacteria,1RPCY@1236|Gammaproteobacteria,1XE7T@135618|Methylococcales	135618|Methylococcales	C	NADH dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NADHdh
TH1_k127_4724286_0	697282.Mettu_2841	6.227e-255	803.0	COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,1RM9Q@1236|Gammaproteobacteria,1XDSI@135618|Methylococcales	135618|Methylococcales	C	Proton-conducting membrane transporter	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
TH1_k127_4763343_2	697282.Mettu_4385	1.887e-59	218.0	2A046@1|root,30N6R@2|Bacteria,1QB85@1224|Proteobacteria,1THXY@1236|Gammaproteobacteria,1XG0K@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_4763343_0	243233.MCA2711	3.891e-212	673.0	COG1141@1|root,COG2124@1|root,COG1141@2|Bacteria,COG2124@2|Bacteria,1MV75@1224|Proteobacteria,1RY69@1236|Gammaproteobacteria,1XFKB@135618|Methylococcales	135618|Methylococcales	C	Cytochrome P450	-	-	1.14.13.70	ko:K05917	ko00100,ko01100,ko01110,ko01130,map00100,map01100,map01110,map01130	M00101	R05640,R05731	RC01442	ko00000,ko00001,ko00002,ko00199,ko01000	-	-	-	p450
TH1_k127_4763343_1	243233.MCA1013	5.637e-180	576.0	COG1033@1|root,COG1033@2|Bacteria,1QW3H@1224|Proteobacteria,1RZA3@1236|Gammaproteobacteria,1XDIY@135618|Methylococcales	1236|Gammaproteobacteria	S	TIGRFAM Hopanoid biosynthesis associated RND transporter like protein HpnN	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
TH1_k127_4767018_4	1116472.MGMO_45c00830	9.16e-17	83.0	COG2168@1|root,COG2168@2|Bacteria,1QIB5@1224|Proteobacteria,1TG5D@1236|Gammaproteobacteria,1XFPY@135618|Methylococcales	135618|Methylococcales	P	TIGRFAM Sulphur relay, TusB DsrH	-	-	-	ko:K07237	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DsrH
TH1_k127_4767018_3	857087.Metme_1820	7.855e-44	161.0	COG2076@1|root,COG2076@2|Bacteria,1MZ6P@1224|Proteobacteria,1S8TD@1236|Gammaproteobacteria,1XFJT@135618|Methylococcales	135618|Methylococcales	U	PFAM Small Multidrug Resistance protein	-	-	-	ko:K11741	-	-	-	-	ko00000,ko02000	2.A.7.1	-	-	Multi_Drug_Res
TH1_k127_4767018_1	857087.Metme_0513	3.399e-99	330.0	COG1723@1|root,COG1723@2|Bacteria,1MWYM@1224|Proteobacteria,1S0KZ@1236|Gammaproteobacteria,1XEQ4@135618|Methylococcales	135618|Methylococcales	S	Uncharacterised ACR, YagE family COG1723	-	-	-	-	-	-	-	-	-	-	-	-	DUF155
TH1_k127_4767018_2	686340.Metal_1942	1.577e-57	205.0	COG2077@1|root,COG2077@2|Bacteria,1RAJ9@1224|Proteobacteria,1S263@1236|Gammaproteobacteria,1XEZ3@135618|Methylococcales	135618|Methylococcales	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	tpx	-	1.11.1.15	ko:K11065	-	-	-	-	ko00000,ko01000	-	-	-	Redoxin
TH1_k127_4767018_0	857087.Metme_3946	1.377e-180	572.0	COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria,1XE5U@135618|Methylococcales	135618|Methylococcales	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
TH1_k127_4783762_1	857087.Metme_0214	1.233e-151	484.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,1RMAJ@1236|Gammaproteobacteria,1XDYK@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016740,GO:0016772,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
TH1_k127_4783762_3	697282.Mettu_1204	2.981e-138	444.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,1RMZ1@1236|Gammaproteobacteria,1XE2M@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
TH1_k127_4783762_6	857087.Metme_4614	4.834e-81	274.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,1RN09@1236|Gammaproteobacteria,1XEE9@135618|Methylococcales	135618|Methylococcales	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
TH1_k127_4783762_9	857087.Metme_0889	1.33e-21	100.0	29NZI@1|root,309XP@2|Bacteria,1QJR3@1224|Proteobacteria,1THS9@1236|Gammaproteobacteria,1XFIJ@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_4783762_4	857087.Metme_4370	1.631e-129	421.0	COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,1RMDQ@1236|Gammaproteobacteria,1XE9V@135618|Methylococcales	135618|Methylococcales	KLT	Tyrosine-protein kinase, subgroup, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
TH1_k127_4783762_5	857087.Metme_4369	8.341e-104	345.0	COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,1RMAB@1236|Gammaproteobacteria,1XEJ6@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF1732)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
TH1_k127_4783762_8	83406.HDN1F_30860	2.839e-41	158.0	COG4969@1|root,COG4969@2|Bacteria,1N7EQ@1224|Proteobacteria,1SCES@1236|Gammaproteobacteria,1J6XX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	NU	Belongs to the N-Me-Phe pilin family	pilA1	-	-	ko:K02650	ko02020,map02020	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.15.2	-	-	N_methyl,Pilin
TH1_k127_4783762_0	697282.Mettu_1198	5.109e-170	539.0	COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,1RNZZ@1236|Gammaproteobacteria,1XEFW@135618|Methylococcales	135618|Methylococcales	F	AIR synthase related protein, C-terminal	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
TH1_k127_4783762_2	697282.Mettu_3598	1.807e-143	460.0	COG3272@1|root,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,1RNMF@1236|Gammaproteobacteria,1XEGF@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF1722)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
TH1_k127_4783762_7	338966.Ppro_2172	2.897e-61	220.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42Q6R@68525|delta/epsilon subdivisions,2WJN4@28221|Deltaproteobacteria,43TK0@69541|Desulfuromonadales	1224|Proteobacteria	T	Domains REC, sigma54 interaction, HTH8	zraR	-	-	ko:K20919	ko05111,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_8,Sigma54_activat
TH1_k127_4800785_2	686340.Metal_3225	1.777e-44	163.0	COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,1S5XD@1236|Gammaproteobacteria,1XFIW@135618|Methylococcales	135618|Methylococcales	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
TH1_k127_4800785_0	1116472.MGMO_62c00030	3.222e-131	428.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria,1XE3U@135618|Methylococcales	135618|Methylococcales	E	Cysteine desulfurase	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
TH1_k127_4800785_1	697282.Mettu_0027	2.238e-72	247.0	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,1S3RW@1236|Gammaproteobacteria,1XF1K@135618|Methylococcales	135618|Methylococcales	K	Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins	-	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
TH1_k127_4832446_0	857087.Metme_2927	6.175e-110	366.0	COG0210@1|root,COG0514@1|root,COG0210@2|Bacteria,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,1RMPG@1236|Gammaproteobacteria,1XFYV@135618|Methylococcales	135618|Methylococcales	L	UvrD-like helicase C-terminal domain	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,UvrD_C
TH1_k127_4844743_0	686340.Metal_1070	4.264e-149	476.0	COG0373@1|root,COG0373@2|Bacteria,1MXX5@1224|Proteobacteria,1S03H@1236|Gammaproteobacteria,1XDMW@135618|Methylococcales	135618|Methylococcales	H	PFAM Methylene-tetrahydromethanopterin dehydrogenase, N-terminal	-	-	-	ko:K10714	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R08059	RC00202	ko00000,ko00001,ko01000	-	-	-	Mpt_N
TH1_k127_4844743_1	1116472.MGMO_8c00070	2.725e-144	463.0	COG1063@1|root,COG1063@2|Bacteria,1QXQ8@1224|Proteobacteria,1S1AP@1236|Gammaproteobacteria,1XDQD@135618|Methylococcales	135618|Methylococcales	E	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal	-	-	-	ko:K10714	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R08059	RC00202	ko00000,ko00001,ko01000	-	-	-	Mpt_N
TH1_k127_4844743_2	697282.Mettu_4362	3.614e-123	402.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1XE8F@135618|Methylococcales	135618|Methylococcales	M	Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)	-	-	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
TH1_k127_4852683_0	697282.Mettu_0752	7.918e-258	799.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1XES4@135618|Methylococcales	135618|Methylococcales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
TH1_k127_4852683_5	272123.Anacy_0671	0.0005003	45.0	COG3744@1|root,COG3744@2|Bacteria,1GDGX@1117|Cyanobacteria,1HSBJ@1161|Nostocales	1117|Cyanobacteria	S	PFAM PilT protein, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TH1_k127_4852683_2	697282.Mettu_1014	1.408e-106	351.0	COG2833@1|root,COG2833@2|Bacteria,1MW0V@1224|Proteobacteria,1RNGA@1236|Gammaproteobacteria,1XEPF@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF455)	-	-	-	-	-	-	-	-	-	-	-	-	DUF455
TH1_k127_4852683_3	697282.Mettu_1013	4.601e-31	126.0	COG5652@1|root,COG5652@2|Bacteria,1NB26@1224|Proteobacteria,1SHZK@1236|Gammaproteobacteria,1XFPF@135618|Methylococcales	135618|Methylococcales	S	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
TH1_k127_4852683_1	686340.Metal_3426	5.614e-197	617.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,1XDZ4@135618|Methylococcales	135618|Methylococcales	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
TH1_k127_4852683_4	857087.Metme_1952	2.378e-11	66.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RR2W@1236|Gammaproteobacteria,1XGZ9@135618|Methylococcales	1236|Gammaproteobacteria	L	PFAM Transposase, IS4-like	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
TH1_k127_4945860_1	1230476.C207_02861	1.094e-73	264.0	COG2114@1|root,COG2114@2|Bacteria,1QWNC@1224|Proteobacteria,2TRQB@28211|Alphaproteobacteria,3JQN6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1,4.6.1.2	ko:K01768,ko:K01769	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF,Guanylate_cyc,HAMP
TH1_k127_4945860_0	686340.Metal_1841	0.0	1046.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,1XEI7@135618|Methylococcales	135618|Methylococcales	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
TH1_k127_4945860_3	686340.Metal_1910	2.149e-56	199.0	COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,1S343@1236|Gammaproteobacteria,1XFAM@135618|Methylococcales	135618|Methylococcales	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TH1_k127_4945860_2	857087.Metme_4580	1.663e-56	203.0	COG2227@1|root,COG2227@2|Bacteria,1RE7I@1224|Proteobacteria,1S6PD@1236|Gammaproteobacteria,1XFCI@135618|Methylococcales	135618|Methylococcales	H	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,TehB
TH1_k127_4948970_3	159087.Daro_0222	1.539e-13	71.0	COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,2VKWB@28216|Betaproteobacteria,2KVQ3@206389|Rhodocyclales	206389|Rhodocyclales	J	COG0480 Translation elongation factors (GTPases)	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
TH1_k127_4948970_0	686340.Metal_3015	9.473e-224	706.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1XEHG@135618|Methylococcales	135618|Methylococcales	F	Belongs to the 5'-nucleotidase family	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid_C
TH1_k127_4948970_1	857087.Metme_3998	6.038e-215	675.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,1RPZC@1236|Gammaproteobacteria,1XDUY@135618|Methylococcales	135618|Methylococcales	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
TH1_k127_4948970_4	696747.NIES39_M00330	8.07e-10	66.0	COG0664@1|root,COG0664@2|Bacteria,1G57E@1117|Cyanobacteria,1HAIX@1150|Oscillatoriales	1117|Cyanobacteria	T	- catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
TH1_k127_4948970_2	243233.MCA2983	1.477e-101	336.0	COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,1RP5A@1236|Gammaproteobacteria,1XF6C@135618|Methylococcales	135618|Methylococcales	P	Inositol monophosphatase family	-	-	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Inositol_P
TH1_k127_5021361_1	857087.Metme_3703	9.439e-137	438.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria,1XDUT@135618|Methylococcales	135618|Methylococcales	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
TH1_k127_5021361_4	686340.Metal_3787	1.236e-40	151.0	COG2331@1|root,COG2331@2|Bacteria,1N6Q9@1224|Proteobacteria,1SCJS@1236|Gammaproteobacteria,1XFHG@135618|Methylococcales	135618|Methylococcales	S	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
TH1_k127_5021361_0	686340.Metal_3788	2.035e-160	513.0	COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,1RNEN@1236|Gammaproteobacteria,1XDZH@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
TH1_k127_5021361_2	697282.Mettu_2880	1.126e-95	319.0	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,1RNPS@1236|Gammaproteobacteria,1XE2X@135618|Methylococcales	135618|Methylococcales	M	(Lipo)protein	-	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
TH1_k127_5021361_3	697282.Mettu_2881	4.685e-70	239.0	COG0847@1|root,COG0847@2|Bacteria,1MUPK@1224|Proteobacteria,1RMMH@1236|Gammaproteobacteria,1XE01@135618|Methylococcales	135618|Methylococcales	L	Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis	rnt	-	-	ko:K03683	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_T
TH1_k127_5023578_0	697282.Mettu_4338	0.0	1030.0	COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,1RMA0@1236|Gammaproteobacteria,1XDQN@135618|Methylococcales	135618|Methylococcales	G	PFAM Glycoside hydrolase, family 3, N-terminal	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
TH1_k127_5023578_6	857087.Metme_0631	3.07e-36	141.0	2FIY3@1|root,34AP0@2|Bacteria,1P269@1224|Proteobacteria,1SSJQ@1236|Gammaproteobacteria,1XGQ4@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5023578_2	580332.Slit_0827	2.919e-213	672.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VH5A@28216|Betaproteobacteria,44VFX@713636|Nitrosomonadales	1224|Proteobacteria	C	PFAM FAD linked oxidase domain protein	glcD	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0033554,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	iJN746.PP_3745,iLF82_1304.LF82_0831,iNRG857_1313.NRG857_14750	FAD-oxidase_C,FAD_binding_4
TH1_k127_5023578_5	686340.Metal_3809	8.097e-63	226.0	COG1739@1|root,COG1739@2|Bacteria,1NFJC@1224|Proteobacteria,1RPBF@1236|Gammaproteobacteria,1XF7X@135618|Methylococcales	135618|Methylococcales	S	PFAM Uncharacterised protein family UPF0029, Impact, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	DUF1949,UPF0029
TH1_k127_5023578_3	1283300.ATXB01000001_gene1937	3.471e-199	636.0	COG1785@1|root,COG1785@2|Bacteria,1MXI2@1224|Proteobacteria,1RNG8@1236|Gammaproteobacteria,1XE21@135618|Methylococcales	135618|Methylococcales	P	Belongs to the alkaline phosphatase family	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase
TH1_k127_5023578_4	1116472.MGMO_143c00090	9.743e-105	344.0	COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,1RPB1@1236|Gammaproteobacteria,1XF7R@135618|Methylococcales	135618|Methylococcales	S	SNARE associated Golgi protein	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
TH1_k127_5023578_1	697282.Mettu_2382	4.429e-282	876.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,1RPM6@1236|Gammaproteobacteria,1XEVW@135618|Methylococcales	135618|Methylococcales	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
TH1_k127_5041958_0	686340.Metal_3570	3.959e-301	930.0	COG0223@1|root,COG1024@1|root,COG0223@2|Bacteria,COG1024@2|Bacteria,1MWYJ@1224|Proteobacteria,1RZSE@1236|Gammaproteobacteria,1XG82@135618|Methylococcales	135618|Methylococcales	IJ	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1,Formyl_trans_C,Formyl_trans_N
TH1_k127_5041958_2	686340.Metal_3569	1.826e-124	407.0	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,1S32F@1236|Gammaproteobacteria,1XEVA@135618|Methylococcales	135618|Methylococcales	K	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
TH1_k127_5041958_1	857087.Metme_1388	3.481e-155	497.0	COG0741@1|root,COG0741@2|Bacteria,1MWKE@1224|Proteobacteria,1RZWQ@1236|Gammaproteobacteria,1XDRV@135618|Methylococcales	135618|Methylococcales	M	Transglycosylase SLT domain	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	SLT
TH1_k127_5041958_4	1307759.JOMJ01000003_gene925	7.345e-14	72.0	28JVR@1|root,2Z9KN@2|Bacteria,1R7WT@1224|Proteobacteria,42T3H@68525|delta/epsilon subdivisions,2WP5T@28221|Deltaproteobacteria,2MCX0@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5041958_3	1357275.AVEL02000076_gene2081	3.174e-18	85.0	COG0583@1|root,COG0583@2|Bacteria,1MVHT@1224|Proteobacteria,1RN7G@1236|Gammaproteobacteria,1Z5WD@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	K	Transcriptional regulator	nhaR	-	-	ko:K03717	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
TH1_k127_5042007_2	697282.Mettu_1845	8.077e-104	346.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,1RPV9@1236|Gammaproteobacteria,1XDQG@135618|Methylococcales	135618|Methylococcales	P	Phosphate transport system permease protein	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3333
TH1_k127_5042007_0	697282.Mettu_1844	0.0	1023.0	COG4590@1|root,COG4590@2|Bacteria,1QTTD@1224|Proteobacteria,1T1GK@1236|Gammaproteobacteria,1XEGE@135618|Methylococcales	135618|Methylococcales	P	PFAM Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
TH1_k127_5042007_1	857087.Metme_4550	1.407e-156	499.0	COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,1RQDH@1236|Gammaproteobacteria,1XE8V@135618|Methylococcales	135618|Methylococcales	P	TIGRFAM phosphate binding protein	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
TH1_k127_5042007_3	1357275.AVEL02000076_gene2081	8.91e-19	87.0	COG0583@1|root,COG0583@2|Bacteria,1MVHT@1224|Proteobacteria,1RN7G@1236|Gammaproteobacteria,1Z5WD@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	K	Transcriptional regulator	nhaR	-	-	ko:K03717	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
TH1_k127_5042239_0	857087.Metme_2637	0.0	1487.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1XEKH@135618|Methylococcales	135618|Methylococcales	L	Bacterial DNA polymerase III, alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
TH1_k127_5063347_0	1123228.AUIH01000011_gene2020	3.126e-82	299.0	COG4585@1|root,COG4585@2|Bacteria,1QSUV@1224|Proteobacteria,1RR41@1236|Gammaproteobacteria,1XNEI@135619|Oceanospirillales	135619|Oceanospirillales	T	COG4585 Signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5063347_1	588932.JHOF01000018_gene1215	9.482e-63	228.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2VFCK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
TH1_k127_5085917_2	234267.Acid_0833	1.699e-28	116.0	COG4453@1|root,COG4453@2|Bacteria	2|Bacteria	K	Protein conserved in bacteria	VY92_07520	-	-	-	-	-	-	-	-	-	-	-	DUF1778
TH1_k127_5085917_3	83406.HDN1F_37230	2.308e-05	50.0	COG0454@1|root,COG0456@2|Bacteria,1N009@1224|Proteobacteria,1T2H1@1236|Gammaproteobacteria,1JAZE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
TH1_k127_5085917_0	1070319.CAGGBEG34_40009	8.406e-56	198.0	COG5499@1|root,COG5499@2|Bacteria,1N89F@1224|Proteobacteria,2VWB3@28216|Betaproteobacteria,1K73X@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K18831	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	HTH_3
TH1_k127_5085917_1	1070319.CAGGBEG34_40008	6.707e-41	152.0	COG4680@1|root,COG4680@2|Bacteria,1N8JN@1224|Proteobacteria,2VX9N@28216|Betaproteobacteria,1K9MJ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	HigB_toxin, RelE-like toxic component of a toxin-antitoxin system	-	-	-	ko:K19166	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HigB_toxin
TH1_k127_5094454_1	1298593.TOL_0839	8.181e-126	412.0	COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,1T05M@1236|Gammaproteobacteria,1XJGZ@135619|Oceanospirillales	135619|Oceanospirillales	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
TH1_k127_5094454_0	1121374.KB891586_gene2672	1.277e-262	824.0	COG0529@1|root,COG2046@1|root,COG0529@2|Bacteria,COG2046@2|Bacteria,1MX0D@1224|Proteobacteria,1RNWT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the synthesis of activated sulfate	cysC	-	2.7.1.25,2.7.7.4	ko:K00860,ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,ATP-sulfurylase,PUA_2
TH1_k127_5094454_2	686340.Metal_2754	1.61e-119	398.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,1XDXK@135618|Methylococcales	135618|Methylococcales	M	Ami_3	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,LysM
TH1_k127_5094454_4	686340.Metal_2657	3.489e-50	182.0	COG0802@1|root,COG0802@2|Bacteria,1RGYU@1224|Proteobacteria,1S6IB@1236|Gammaproteobacteria,1XFAT@135618|Methylococcales	135618|Methylococcales	S	PFAM Uncharacterised protein family UPF0079, ATPase bacteria	-	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
TH1_k127_5094454_3	697282.Mettu_4346	1.008e-83	283.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,1RMPS@1236|Gammaproteobacteria,1XEGQ@135618|Methylococcales	135618|Methylococcales	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
TH1_k127_5105445_1	697282.Mettu_0132	8.491e-178	560.0	COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,1RMEQ@1236|Gammaproteobacteria,1XDXY@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
TH1_k127_5105445_4	697282.Mettu_0131	4.933e-80	274.0	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,1S64Q@1236|Gammaproteobacteria,1XDVG@135618|Methylococcales	135618|Methylococcales	S	Competence protein	comF	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
TH1_k127_5105445_2	686340.Metal_0922	6.583e-158	504.0	COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,1RQYE@1236|Gammaproteobacteria,1XEG4@135618|Methylococcales	135618|Methylococcales	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TH1_k127_5105445_6	309798.COPRO5265_0216	3.757e-44	173.0	COG1105@1|root,COG1105@2|Bacteria,1TQ36@1239|Firmicutes,249RK@186801|Clostridia,42GCP@68295|Thermoanaerobacterales	186801|Clostridia	H	Belongs to the carbohydrate kinase PfkB family. LacC subfamily	pfkB	-	2.7.1.56	ko:K00882	ko00051,map00051	-	R02071	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
TH1_k127_5105445_3	857087.Metme_2003	2.54e-136	440.0	COG1475@1|root,COG1475@2|Bacteria	2|Bacteria	K	chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	KorB,ParBc
TH1_k127_5105445_0	857087.Metme_3278	4.336e-313	970.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RQ2G@1236|Gammaproteobacteria,1XDIS@135618|Methylococcales	135618|Methylococcales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
TH1_k127_5105445_7	686340.Metal_2160	1.222e-26	110.0	2DN4B@1|root,32VFQ@2|Bacteria,1REFD@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF2490)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2490
TH1_k127_5108472_4	1500894.JQNN01000001_gene3137	5.136e-84	284.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2VJI3@28216|Betaproteobacteria,475IE@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TH1_k127_5108472_1	697282.Mettu_0122	1.089e-137	441.0	COG0842@1|root,COG0842@2|Bacteria,1MVUG@1224|Proteobacteria,1RNF7@1236|Gammaproteobacteria,1XDP2@135618|Methylococcales	135618|Methylococcales	V	TIGRFAM alcohol ABC transporter, permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TH1_k127_5108472_3	1116472.MGMO_44c00220	1.786e-103	342.0	COG1131@1|root,COG1131@2|Bacteria,1MX56@1224|Proteobacteria,1S0C7@1236|Gammaproteobacteria,1XDVN@135618|Methylococcales	135618|Methylococcales	V	TIGRFAM ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TH1_k127_5108472_0	697282.Mettu_0120	4.932e-150	479.0	COG3391@1|root,COG3391@2|Bacteria,1P862@1224|Proteobacteria,1RQZK@1236|Gammaproteobacteria,1XDUS@135618|Methylococcales	135618|Methylococcales	S	TIGRFAM PQQ-dependent catabolism-associated beta-propeller protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Lactonase
TH1_k127_5108472_2	1116472.MGMO_44c00200	1.348e-131	428.0	COG0683@1|root,COG0683@2|Bacteria,1MWGW@1224|Proteobacteria,1RQ5G@1236|Gammaproteobacteria,1XDS8@135618|Methylococcales	135618|Methylococcales	E	TIGRFAM ABC transporter, substrate binding protein, PQQ-dependent alcohol dehydrogenase system	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
TH1_k127_5114454_4	857087.Metme_1057	8.385e-81	275.0	COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,1XDZY@135618|Methylococcales	135618|Methylococcales	M	TIGRFAM Lytic murein transglycosylase B	-	-	-	ko:K08305	-	-	-	-	ko00000,ko01000,ko01011	-	GH103	-	SLT_2
TH1_k127_5114454_1	697282.Mettu_1394	6.434e-181	572.0	COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,1RMEJ@1236|Gammaproteobacteria,1XEKN@135618|Methylococcales	135618|Methylococcales	M	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
TH1_k127_5114454_0	697282.Mettu_1393	4.73e-272	849.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,1XDPF@135618|Methylococcales	135618|Methylococcales	M	Catalyzes cross-linking of the peptidoglycan cell wall	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
TH1_k127_5114454_5	697282.Mettu_1392	2.912e-53	192.0	COG2891@1|root,COG2891@2|Bacteria,1RER7@1224|Proteobacteria,1S8VI@1236|Gammaproteobacteria,1XF98@135618|Methylococcales	135618|Methylococcales	M	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins	mreD	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
TH1_k127_5114454_3	697282.Mettu_1391	2.718e-94	317.0	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,1RMK4@1236|Gammaproteobacteria,1XECP@135618|Methylococcales	135618|Methylococcales	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
TH1_k127_5114454_2	697282.Mettu_1390	8.009e-159	502.0	COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,1RN82@1236|Gammaproteobacteria,1XESQ@135618|Methylococcales	135618|Methylococcales	D	TIGRFAM Cell shape determining protein MreB Mrl	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
TH1_k127_5138902_2	1128427.KB904821_gene1408	7.481e-91	318.0	COG0457@1|root,COG0457@2|Bacteria,1G3JD@1117|Cyanobacteria,1H853@1150|Oscillatoriales	1117|Cyanobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5138902_4	357808.RoseRS_4372	9.27e-15	76.0	2E712@1|root,331JU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5138902_5	946483.Cenrod_0842	4.329e-14	74.0	2E7P1@1|root,31AV7@2|Bacteria,1NNQI@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5138902_3	324925.Ppha_1720	6.967e-41	155.0	COG3744@1|root,COG3744@2|Bacteria	2|Bacteria	S	ribonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TH1_k127_5138902_0	686340.Metal_3442	3.807e-148	476.0	COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,1RNXV@1236|Gammaproteobacteria,1XEAU@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
TH1_k127_5138902_1	697282.Mettu_2003	5.695e-135	434.0	COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,1RNYH@1236|Gammaproteobacteria,1XEIY@135618|Methylococcales	135618|Methylococcales	E	Belongs to the TrpC family	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
TH1_k127_51484_0	686340.Metal_0510	0.0	1298.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1XEP9@135618|Methylococcales	135618|Methylococcales	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
TH1_k127_5148953_1	697282.Mettu_2833	1.15e-120	392.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RMN0@1236|Gammaproteobacteria,1XE9F@135618|Methylococcales	135618|Methylococcales	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
TH1_k127_5148953_0	697282.Mettu_2832	2.936e-164	526.0	COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,1RPE8@1236|Gammaproteobacteria,1XDW4@135618|Methylococcales	135618|Methylococcales	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
TH1_k127_5148953_2	697282.Mettu_2831	4.096e-76	260.0	COG0494@1|root,COG0494@2|Bacteria,1RDMW@1224|Proteobacteria,1RPZV@1236|Gammaproteobacteria,1XEY6@135618|Methylococcales	135618|Methylococcales	L	NUDIX domain	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
TH1_k127_5148953_3	686340.Metal_1402	7.019e-47	173.0	COG2132@1|root,COG2132@2|Bacteria,1R8SR@1224|Proteobacteria,1RUEX@1236|Gammaproteobacteria,1XEFZ@135618|Methylococcales	135618|Methylococcales	Q	PFAM Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2,Cu-oxidase_3
TH1_k127_5179972_2	697282.Mettu_2496	2.68e-52	188.0	COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,1S656@1236|Gammaproteobacteria,1XF9R@135618|Methylococcales	135618|Methylococcales	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
TH1_k127_5179972_1	697282.Mettu_2498	4.397e-62	226.0	COG0845@1|root,COG0845@2|Bacteria,1R6JG@1224|Proteobacteria,1SEA3@1236|Gammaproteobacteria,1XF38@135618|Methylococcales	135618|Methylococcales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5179972_0	697282.Mettu_3990	0.0	1101.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1RNIF@1236|Gammaproteobacteria,1XE0G@135618|Methylococcales	135618|Methylococcales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
TH1_k127_51833_0	857087.Metme_2360	2.429e-112	368.0	COG1156@1|root,COG1156@2|Bacteria,1R4RB@1224|Proteobacteria,1RQ6N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	-	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
TH1_k127_51833_1	715451.ambt_10600	4.105e-44	173.0	2DV2C@1|root,33TPD@2|Bacteria,1PAUI@1224|Proteobacteria	1224|Proteobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
TH1_k127_5186129_0	857087.Metme_1829	4.095e-288	906.0	28HB2@1|root,2Z7N8@2|Bacteria,1P4RV@1224|Proteobacteria,1RN0X@1236|Gammaproteobacteria,1XG5I@135618|Methylococcales	135618|Methylococcales	M	Fatty acid cis/trans isomerase (CTI)	-	-	-	-	-	-	-	-	-	-	-	-	CTI
TH1_k127_5190894_3	1454004.AW11_00595	3.694e-105	351.0	COG0589@1|root,COG0589@2|Bacteria,1PE08@1224|Proteobacteria,2VNHV@28216|Betaproteobacteria	28216|Betaproteobacteria	T	universal stress protein	uspA	-	-	-	-	-	-	-	-	-	-	-	Usp
TH1_k127_5190894_0	768671.ThimaDRAFT_2610	1.475e-237	745.0	COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,1RNVR@1236|Gammaproteobacteria,1WXNK@135613|Chromatiales	135613|Chromatiales	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
TH1_k127_5190894_2	580332.Slit_2150	4.472e-110	363.0	COG1075@1|root,COG1075@2|Bacteria	2|Bacteria	KLT	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5190894_1	261292.Nit79A3_2534	1.055e-154	494.0	COG4313@1|root,COG4313@2|Bacteria,1PC95@1224|Proteobacteria,2VWTG@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
TH1_k127_5190894_5	768671.ThimaDRAFT_2609	7.298e-06	50.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales	135613|Chromatiales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3,LysM
TH1_k127_5190894_4	261292.Nit79A3_2538	1.616e-25	105.0	2AGH7@1|root,316PS@2|Bacteria,1PXV8@1224|Proteobacteria,2WD68@28216|Betaproteobacteria,373ZT@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5192238_3	717231.Flexsi_0563	4.123e-09	67.0	COG0745@1|root,COG0834@1|root,COG3829@1|root,COG3852@1|root,COG0745@2|Bacteria,COG0834@2|Bacteria,COG3829@2|Bacteria,COG3852@2|Bacteria,2GFVU@200930|Deferribacteres	200930|Deferribacteres	T	Bacterial periplasmic substrate-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS,PAS_4,PAS_9,Response_reg,SBP_bac_3
TH1_k127_5192238_2	582744.Msip34_2415	2.68e-80	272.0	COG0432@1|root,COG0432@2|Bacteria,1RA5G@1224|Proteobacteria,2W271@28216|Betaproteobacteria,2KMMP@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
TH1_k127_5192238_1	697282.Mettu_2902	4.609e-139	451.0	COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1RPVP@1236|Gammaproteobacteria,1XDS3@135618|Methylococcales	135618|Methylococcales	S	AI-2E family transporter	-	-	-	ko:K03548	-	-	-	-	ko00000,ko02000	2.A.86.1	-	-	AI-2E_transport
TH1_k127_5192238_0	396588.Tgr7_2615	0.0	1427.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RMPV@1236|Gammaproteobacteria,1WW6H@135613|Chromatiales	135613|Chromatiales	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
TH1_k127_5194005_3	686340.Metal_0947	2.616e-40	151.0	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,1RMWC@1236|Gammaproteobacteria,1XDQV@135618|Methylococcales	135618|Methylococcales	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
TH1_k127_5194005_2	857087.Metme_3964	3.982e-52	186.0	COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,1S5XX@1236|Gammaproteobacteria,1XFFD@135618|Methylococcales	135618|Methylococcales	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
TH1_k127_5194005_4	472759.Nhal_0929	1.547e-36	144.0	COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,1S68H@1236|Gammaproteobacteria,1WYKN@135613|Chromatiales	135613|Chromatiales	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	-	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
TH1_k127_5194005_0	1116472.MGMO_37c00170	7.981e-132	426.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,1XDWR@135618|Methylococcales	135618|Methylococcales	D	recombinase XerD	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TH1_k127_5194005_1	1116472.MGMO_37c00180	8.677e-126	406.0	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,1SJRD@1236|Gammaproteobacteria,1XEFB@135618|Methylococcales	135618|Methylococcales	M	Acyl- acyl-carrier-protein --UDP-N-acetylglucosamine O-acyltransferase	-	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
TH1_k127_5194005_5	694430.Natoc_2696	2.041e-14	78.0	COG0589@1|root,arCOG02053@2157|Archaea,2XX8Y@28890|Euryarchaeota,23VQJ@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TH1_k127_5228016_1	697282.Mettu_3952	9.525e-148	473.0	COG0042@1|root,COG0042@2|Bacteria,1MUY1@1224|Proteobacteria,1RN28@1236|Gammaproteobacteria,1XEQZ@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs	dusA	-	-	ko:K05539	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
TH1_k127_5228016_3	686340.Metal_0780	1.828e-96	327.0	COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,1RMQM@1236|Gammaproteobacteria,1XE17@135618|Methylococcales	135618|Methylococcales	F	TIGRFAM GTP cyclohydrolase I	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
TH1_k127_5228016_2	697282.Mettu_3954	2.079e-135	441.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,1RMMS@1236|Gammaproteobacteria,1XDP3@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
TH1_k127_5228016_0	686340.Metal_2681	3.274e-160	516.0	COG0477@1|root,COG2814@2|Bacteria,1MUZ8@1224|Proteobacteria,1T1NH@1236|Gammaproteobacteria,1XEBV@135618|Methylococcales	135618|Methylococcales	EGP	PFAM Major Facilitator Superfamily	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
TH1_k127_5228016_4	243233.MCA2058	5.327e-86	286.0	COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,1RPSM@1236|Gammaproteobacteria,1XDPY@135618|Methylococcales	135618|Methylococcales	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
TH1_k127_5271696_11	765913.ThidrDRAFT_0571	1.593e-14	75.0	COG1821@1|root,COG1821@2|Bacteria,1RBY6@1224|Proteobacteria,1S7TK@1236|Gammaproteobacteria,1X0VJ@135613|Chromatiales	135613|Chromatiales	S	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3
TH1_k127_5271696_5	697282.Mettu_2800	1.068e-101	342.0	COG1548@1|root,COG1548@2|Bacteria,1RAMA@1224|Proteobacteria,1S26G@1236|Gammaproteobacteria,1XDXI@135618|Methylococcales	135618|Methylococcales	GK	PFAM Hydantoinase oxoprolinase	-	-	-	-	-	-	-	-	-	-	-	-	Hydantoinase_A
TH1_k127_5271696_1	697282.Mettu_4255	3.246e-197	625.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1XDNC@135618|Methylococcales	135618|Methylococcales	EH	synthase component I	pabB	-	2.6.1.85	ko:K01665	ko00790,map00790	-	R01716	RC00010,RC01418	ko00000,ko00001,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
TH1_k127_5271696_9	697282.Mettu_4254	7.392e-42	167.0	COG2054@1|root,COG2054@2|Bacteria,1MZY4@1224|Proteobacteria,1S9PH@1236|Gammaproteobacteria,1XFEA@135618|Methylococcales	135618|Methylococcales	S	Amino acid kinase family	-	-	-	-	-	-	-	-	-	-	-	-	AA_kinase
TH1_k127_5271696_6	697282.Mettu_0423	9.566e-70	243.0	28NM7@1|root,33VCA@2|Bacteria,1NVEJ@1224|Proteobacteria,1SNCQ@1236|Gammaproteobacteria,1XEVG@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF2959)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2959
TH1_k127_5271696_10	686340.Metal_1893	6.505e-32	131.0	28WBY@1|root,2ZICC@2|Bacteria,1PB9T@1224|Proteobacteria,1SU2T@1236|Gammaproteobacteria,1XFJ6@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5271696_0	697282.Mettu_0425	5.845e-198	632.0	COG0699@1|root,COG0699@2|Bacteria,1RKUD@1224|Proteobacteria,1T537@1236|Gammaproteobacteria,1XE48@135618|Methylococcales	135618|Methylococcales	S	50S ribosome-binding GTPase	-	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
TH1_k127_5271696_4	1283300.ATXB01000001_gene1614	3.074e-113	387.0	COG0699@1|root,COG0699@2|Bacteria,1RGJ8@1224|Proteobacteria,1S42V@1236|Gammaproteobacteria,1XE9A@135618|Methylococcales	135618|Methylococcales	S	50S ribosome-binding GTPase	-	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
TH1_k127_5271696_3	697282.Mettu_0779	2.487e-118	387.0	COG0697@1|root,COG0697@2|Bacteria,1QQY8@1224|Proteobacteria,1RRQ6@1236|Gammaproteobacteria,1XECH@135618|Methylococcales	135618|Methylococcales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TH1_k127_5271696_8	697282.Mettu_0658	7.912e-59	211.0	2AW3I@1|root,31MYD@2|Bacteria,1QJQC@1224|Proteobacteria,1THRG@1236|Gammaproteobacteria,1XFFQ@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PRA-PH
TH1_k127_5271696_7	1207075.PputUW4_03263	3.204e-66	236.0	COG0726@1|root,COG0726@2|Bacteria	2|Bacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
TH1_k127_5271696_2	686340.Metal_1483	2.738e-163	524.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,1T1MS@1236|Gammaproteobacteria,1XH11@135618|Methylococcales	135618|Methylococcales	P	Transporter associated domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
TH1_k127_5271696_12	715451.ambt_17675	7.203e-13	71.0	COG3385@1|root,COG5659@1|root,COG3385@2|Bacteria,COG5659@2|Bacteria,1R97Q@1224|Proteobacteria,1RRDP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
TH1_k127_5283106_13	13035.Dacsa_2637	5.795e-18	84.0	COG1598@1|root,COG1598@2|Bacteria,1GAQW@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5283106_3	697282.Mettu_1998	2.13e-121	396.0	COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,1RPUJ@1236|Gammaproteobacteria,1XESJ@135618|Methylococcales	135618|Methylococcales	T	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP	apaH	-	3.6.1.41	ko:K01525	ko00230,map00230	-	R00125	RC00002	ko00000,ko00001,ko01000	-	-	-	Metallophos
TH1_k127_5283106_8	857087.Metme_0098	2.349e-53	192.0	COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,1S8SE@1236|Gammaproteobacteria,1XF63@135618|Methylococcales	135618|Methylococcales	P	ApaG domain	apaG	-	-	ko:K06195	-	-	-	-	ko00000	-	-	-	DUF525
TH1_k127_5283106_6	686340.Metal_1799	3.071e-78	269.0	COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,1RNJW@1236|Gammaproteobacteria,1XDPV@135618|Methylococcales	135618|Methylococcales	Q	MlaC protein	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
TH1_k127_5283106_2	697282.Mettu_2540	8.946e-162	515.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,1XE5V@135618|Methylococcales	135618|Methylococcales	H	Belongs to the ALAD family	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
TH1_k127_5283106_4	697282.Mettu_2538	9.069e-120	390.0	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,1RPB7@1236|Gammaproteobacteria,1XDS5@135618|Methylococcales	135618|Methylococcales	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
TH1_k127_5283106_9	686340.Metal_3936	2.28e-33	134.0	COG1917@1|root,COG1917@2|Bacteria,1MZNT@1224|Proteobacteria,1S8TU@1236|Gammaproteobacteria,1XFM1@135618|Methylococcales	135618|Methylococcales	S	Cupin domain	-	-	-	ko:K11312	-	-	-	-	ko00000	-	-	-	Cupin_2
TH1_k127_5283106_10	1116472.MGMO_11c00640	5.02e-32	130.0	2B2IA@1|root,31V3C@2|Bacteria,1QJQD@1224|Proteobacteria,1THRH@1236|Gammaproteobacteria,1XFFW@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5283106_1	697282.Mettu_2337	2.07e-238	753.0	COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,1RPH9@1236|Gammaproteobacteria,1XDJ9@135618|Methylococcales	135618|Methylococcales	E	Domain of unknown function (DUF3488)	-	-	2.3.2.13	ko:K22452	-	-	-	-	ko00000,ko01000	-	-	-	DUF3488,DUF4129,Transglut_core
TH1_k127_5283106_0	857087.Metme_0490	0.0	1124.0	COG2183@1|root,COG2183@2|Bacteria,1MUA7@1224|Proteobacteria,1RMNH@1236|Gammaproteobacteria,1XDKJ@135618|Methylococcales	135618|Methylococcales	K	S1, RNA binding domain	-	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
TH1_k127_5283106_12	686340.Metal_2664	4.1e-23	105.0	2EAWF@1|root,31QMM@2|Bacteria,1QJRB@1224|Proteobacteria,1THSJ@1236|Gammaproteobacteria,1XFS8@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5283106_7	338966.Ppro_0418	7.092e-78	272.0	COG4786@1|root,COG4786@2|Bacteria,1MZXB@1224|Proteobacteria,42MTK@68525|delta/epsilon subdivisions,2WM8U@28221|Deltaproteobacteria,43T3T@69541|Desulfuromonadales	28221|Deltaproteobacteria	N	Protein of unknown function (DUF2950)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2950
TH1_k127_5283106_11	1207075.PputUW4_02254	1.297e-25	123.0	COG3064@1|root,COG3064@2|Bacteria,1MXPS@1224|Proteobacteria,1RQIV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Protein of unknown function (DUF3300)	yacH	-	-	-	-	-	-	-	-	-	-	-	DUF3300
TH1_k127_5283106_5	697282.Mettu_3842	1.17e-78	274.0	COG0419@1|root,COG0419@2|Bacteria,1MVTQ@1224|Proteobacteria,1RQFM@1236|Gammaproteobacteria,1XERR@135618|Methylococcales	135618|Methylococcales	L	P-loop containing region of AAA domain	-	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SbcCD_C
TH1_k127_5284458_0	697282.Mettu_1676	4.143e-243	760.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPES@1236|Gammaproteobacteria,1XEJJ@135618|Methylococcales	135618|Methylococcales	S	ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn
TH1_k127_5284458_3	697282.Mettu_1678	1.418e-55	200.0	2AGAT@1|root,316GA@2|Bacteria,1NHNF@1224|Proteobacteria,1SSQF@1236|Gammaproteobacteria,1XF7C@135618|Methylococcales	135618|Methylococcales	S	YcxB-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YcxB
TH1_k127_5284458_4	1116472.MGMO_143c00070	8.749e-35	136.0	2C1YJ@1|root,32ZXK@2|Bacteria,1N98H@1224|Proteobacteria,1SD8N@1236|Gammaproteobacteria,1XFAR@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF2782)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2782
TH1_k127_5284458_5	686340.Metal_3495	2.008e-16	85.0	COG4701@1|root,COG4701@2|Bacteria,1NHRC@1224|Proteobacteria,1SDJY@1236|Gammaproteobacteria,1XFP6@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
TH1_k127_5284458_1	697282.Mettu_1516	1.003e-164	522.0	COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,1RQ72@1236|Gammaproteobacteria,1XE5R@135618|Methylococcales	135618|Methylococcales	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
TH1_k127_5284458_2	857087.Metme_0253	1.663e-84	285.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria,1XESR@135618|Methylococcales	135618|Methylococcales	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
TH1_k127_5290294_1	857087.Metme_4547	4.551e-135	434.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,1RNUF@1236|Gammaproteobacteria,1XDTC@135618|Methylococcales	135618|Methylococcales	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
TH1_k127_5290294_2	697282.Mettu_1847	3.817e-97	324.0	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,1RMW5@1236|Gammaproteobacteria,1XENE@135618|Methylococcales	135618|Methylococcales	P	Plays a role in the regulation of phosphate uptake	-	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
TH1_k127_5290294_6	1121875.KB907553_gene20	5.972e-05	45.0	COG5361@1|root,COG5361@2|Bacteria,4NKSK@976|Bacteroidetes,1IARY@117743|Flavobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
TH1_k127_5290294_4	690850.Desaf_0975	7.812e-21	94.0	2ADPE@1|root,313EG@2|Bacteria,1NEWZ@1224|Proteobacteria,42V0P@68525|delta/epsilon subdivisions,2WSFD@28221|Deltaproteobacteria,2MFC5@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Glycine-zipper domain	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp
TH1_k127_5290294_3	690850.Desaf_0974	1.893e-39	150.0	2E8QN@1|root,3331M@2|Bacteria,1ND4I@1224|Proteobacteria,430TR@68525|delta/epsilon subdivisions,2WVZ7@28221|Deltaproteobacteria,2MF52@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5290294_0	1116472.MGMO_83c00220	4.148e-201	638.0	COG3011@1|root,COG3011@2|Bacteria,1N0MB@1224|Proteobacteria	1224|Proteobacteria	S	Lipase maturation factor	-	-	-	-	-	-	-	-	-	-	-	-	DUF393,LMF1
TH1_k127_5290294_5	1116472.MGMO_107c00090	2.092e-06	49.0	COG3239@1|root,COG3239@2|Bacteria,1MW29@1224|Proteobacteria,1RPHS@1236|Gammaproteobacteria,1XF6V@135618|Methylococcales	135618|Methylococcales	I	Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
TH1_k127_5316277_3	697282.Mettu_1085	6.311e-80	270.0	COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,1RPF6@1236|Gammaproteobacteria,1XEWS@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
TH1_k127_5316277_1	697282.Mettu_1084	1.958e-169	539.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1XDU1@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
TH1_k127_5316277_0	697282.Mettu_1082	7.16e-193	606.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria,1XDUA@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
TH1_k127_5316277_5	675806.VII_003360	1.811e-56	200.0	COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,1S3VP@1236|Gammaproteobacteria,1XWZM@135623|Vibrionales	135623|Vibrionales	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
TH1_k127_5316277_6	686340.Metal_2669	5.305e-54	194.0	COG3019@1|root,COG3019@2|Bacteria,1MZ9V@1224|Proteobacteria,1S9CQ@1236|Gammaproteobacteria,1XFBS@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function, DUF	-	-	-	-	-	-	-	-	-	-	-	-	DUF411
TH1_k127_5316277_2	686340.Metal_2668	1.173e-107	358.0	COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,1RNUY@1236|Gammaproteobacteria,1XETB@135618|Methylococcales	135618|Methylococcales	F	Belongs to the bacterial glucokinase family	-	-	-	-	-	-	-	-	-	-	-	-	Glucokinase
TH1_k127_5316277_4	857087.Metme_2069	1.346e-76	263.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,1T1JB@1236|Gammaproteobacteria,1XEG6@135618|Methylococcales	135618|Methylococcales	C	Belongs to the AlaDH PNT family	-	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
TH1_k127_53204_6	697282.Mettu_2454	2.484e-09	59.0	COG1714@1|root,COG1714@2|Bacteria,1N4N8@1224|Proteobacteria,1S9C5@1236|Gammaproteobacteria,1XFBI@135618|Methylococcales	135618|Methylococcales	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
TH1_k127_53204_2	697282.Mettu_2536	1.953e-131	428.0	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,1RM8H@1236|Gammaproteobacteria,1XE35@135618|Methylococcales	135618|Methylococcales	S	Permease YjgP YjgQ	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
TH1_k127_53204_3	857087.Metme_4390	3.98e-114	378.0	COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,1RMN5@1236|Gammaproteobacteria,1XDW7@135618|Methylococcales	135618|Methylococcales	S	Permease YjgP YjgQ	-	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
TH1_k127_53204_0	697282.Mettu_2525	2.026e-200	636.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,1RNM1@1236|Gammaproteobacteria,1XDR9@135618|Methylococcales	135618|Methylococcales	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
TH1_k127_53204_4	697282.Mettu_2524	2.686e-40	153.0	COG2927@1|root,COG2927@2|Bacteria,1MZ3V@1224|Proteobacteria,1SEQD@1236|Gammaproteobacteria,1XFBN@135618|Methylococcales	135618|Methylococcales	L	PFAM DNA polymerase III chi subunit, HolC	-	-	2.7.7.7	ko:K02339	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_chi
TH1_k127_53204_1	697282.Mettu_2523	8.892e-197	618.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1XEJP@135618|Methylococcales	135618|Methylococcales	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
TH1_k127_5328530_5	686340.Metal_1904	3.361e-60	209.0	COG1132@1|root,COG1132@2|Bacteria,1N1Z8@1224|Proteobacteria,1RPVC@1236|Gammaproteobacteria,1XEI6@135618|Methylococcales	135618|Methylococcales	V	ABC transporter transmembrane region	-	-	-	ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1	-	-	ABC_membrane,ABC_tran
TH1_k127_5328530_2	686340.Metal_1903	3.382e-111	366.0	COG0613@1|root,COG0613@2|Bacteria,1MWIH@1224|Proteobacteria,1RNCG@1236|Gammaproteobacteria,1XEAW@135618|Methylococcales	135618|Methylococcales	S	PHP domain	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
TH1_k127_5328530_3	697282.Mettu_0715	3.513e-95	313.0	COG0503@1|root,COG0503@2|Bacteria,1MVZ6@1224|Proteobacteria,1S2N9@1236|Gammaproteobacteria,1XEUU@135618|Methylococcales	135618|Methylococcales	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
TH1_k127_5328530_1	697282.Mettu_2603	1.438e-169	538.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,1RR2F@1236|Gammaproteobacteria,1XDVC@135618|Methylococcales	135618|Methylococcales	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
TH1_k127_5328530_4	857087.Metme_3301	4.267e-62	220.0	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,1S5W5@1236|Gammaproteobacteria,1XF1X@135618|Methylococcales	135618|Methylococcales	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
TH1_k127_5328530_0	857087.Metme_3300	1.42e-170	538.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,1XDUN@135618|Methylococcales	135618|Methylococcales	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
TH1_k127_5360456_2	697282.Mettu_0698	3.957e-48	173.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1XDY1@135618|Methylococcales	135618|Methylococcales	IQ	Belongs to the beta-ketoacyl-ACP synthases family	fabB	-	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TH1_k127_5360456_1	686340.Metal_1906	7.249e-97	317.0	COG0764@1|root,COG0764@2|Bacteria,1MWV8@1224|Proteobacteria,1RP6W@1236|Gammaproteobacteria,1XDP9@135618|Methylococcales	135618|Methylococcales	I	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length	fabA	-	4.2.1.59,5.3.3.14	ko:K01716	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639	RC00831,RC01078,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
TH1_k127_5360456_0	1116472.MGMO_122c00160	8.995e-120	392.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,1XEAS@135618|Methylococcales	135618|Methylococcales	M	Soluble lytic murein transglycosylase L domain	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,SLT_L
TH1_k127_5371679_0	1454004.AW11_02393	2.155e-103	346.0	COG4313@1|root,COG4313@2|Bacteria,1PRCN@1224|Proteobacteria,2VQHT@28216|Betaproteobacteria,1KQK1@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	Protein involved in meta-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
TH1_k127_5371679_3	105559.Nwat_0848	7.556e-22	101.0	2E5SP@1|root,330H2@2|Bacteria,1NDBY@1224|Proteobacteria,1T9MI@1236|Gammaproteobacteria,1X1I2@135613|Chromatiales	135613|Chromatiales	S	Glycine-zipper domain	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_YMGG
TH1_k127_5371679_1	525897.Dbac_1078	9.413e-54	195.0	COG2930@1|root,COG2930@2|Bacteria,1RAIB@1224|Proteobacteria,42S9D@68525|delta/epsilon subdivisions,2WNWH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	(twin-arginine translocation) pathway signal	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5371679_2	1496688.ER33_08635	6.368e-39	146.0	COG4320@1|root,COG4320@2|Bacteria,1G0BG@1117|Cyanobacteria	1117|Cyanobacteria	S	Uncharacterized protein conserved in bacteria (DUF2252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
TH1_k127_5372981_1	697282.Mettu_0705	6.165e-150	480.0	COG1276@1|root,COG1276@2|Bacteria,1MXRN@1224|Proteobacteria,1SKDQ@1236|Gammaproteobacteria,1XDKC@135618|Methylococcales	135618|Methylococcales	P	Copper resistance	-	-	-	ko:K07245	-	-	-	-	ko00000,ko02000	9.B.62.1	-	-	CopD
TH1_k127_5372981_0	697282.Mettu_0704	0.0	1025.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1XDS0@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
TH1_k127_5372981_3	330214.NIDE0010	2.249e-33	131.0	COG1741@1|root,COG1741@2|Bacteria,3J125@40117|Nitrospirae	40117|Nitrospirae	S	Pirin	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
TH1_k127_5372981_2	697282.Mettu_0683	1.063e-77	260.0	COG2154@1|root,COG2154@2|Bacteria,1RIEN@1224|Proteobacteria,1S6QN@1236|Gammaproteobacteria,1XF13@135618|Methylococcales	135618|Methylococcales	H	Pterin 4 alpha carbinolamine dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
TH1_k127_538591_0	686340.Metal_3319	0.0	2078.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1XE7C@135618|Methylococcales	135618|Methylococcales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
TH1_k127_538591_3	857087.Metme_3821	8.574e-69	234.0	COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,1S3WB@1236|Gammaproteobacteria,1XF01@135618|Methylococcales	135618|Methylococcales	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
TH1_k127_538591_2	686340.Metal_3317	2.666e-78	263.0	COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,1RN77@1236|Gammaproteobacteria,1XENW@135618|Methylococcales	135618|Methylococcales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
TH1_k127_538591_1	686340.Metal_3316	3.125e-255	791.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,1XDNZ@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
TH1_k127_54016_0	715451.ambt_03875	1.853e-138	487.0	COG2911@1|root,COG3209@1|root,COG2911@2|Bacteria,COG3209@2|Bacteria,1R1M5@1224|Proteobacteria,1RQBW@1236|Gammaproteobacteria,465Y0@72275|Alteromonadaceae	1236|Gammaproteobacteria	A	Protein conserved in bacteria	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	-
TH1_k127_54016_1	686340.Metal_1818	5.364e-122	397.0	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,1RMFR@1236|Gammaproteobacteria,1XETK@135618|Methylococcales	135618|Methylococcales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes	rpoH	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r4
TH1_k127_5403017_1	1131812.JQMS01000001_gene2382	1.87e-44	180.0	COG0845@1|root,COG0845@2|Bacteria,4NI7Q@976|Bacteroidetes	976|Bacteroidetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5403017_0	686340.Metal_2753	0.0	1136.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,1XE20@135618|Methylococcales	135618|Methylococcales	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
TH1_k127_5422457_1	697282.Mettu_1740	3.091e-95	316.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,1RQ2D@1236|Gammaproteobacteria,1XEAH@135618|Methylococcales	135618|Methylococcales	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
TH1_k127_5422457_0	1173020.Cha6605_1920	1.34e-164	526.0	COG2211@1|root,COG2211@2|Bacteria,1GQN5@1117|Cyanobacteria	1117|Cyanobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TH1_k127_5422457_2	290317.Cpha266_2057	8.251e-87	291.0	28MI1@1|root,2ZAUV@2|Bacteria	2|Bacteria	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
TH1_k127_5422457_3	290317.Cpha266_2056	1.509e-39	150.0	2E8SU@1|root,3333K@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5422457_5	1255043.TVNIR_2275	1.296e-18	87.0	COG1943@1|root,COG1943@2|Bacteria,1RCWW@1224|Proteobacteria,1S3ZJ@1236|Gammaproteobacteria,1WY9M@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
TH1_k127_5422457_4	243233.MCA0960	1.689e-22	97.0	COG0346@1|root,COG0346@2|Bacteria,1QJPD@1224|Proteobacteria,1THQB@1236|Gammaproteobacteria,1XFAI@135618|Methylococcales	135618|Methylococcales	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TH1_k127_5432099_2	857087.Metme_3420	5.519e-20	91.0	2C3QV@1|root,2Z7YP@2|Bacteria,1MXAM@1224|Proteobacteria,1RNIA@1236|Gammaproteobacteria,1XEFQ@135618|Methylococcales	135618|Methylococcales	S	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
TH1_k127_5432099_0	243233.MCA0594	2.075e-225	706.0	COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,1RP5H@1236|Gammaproteobacteria,1XE4N@135618|Methylococcales	135618|Methylococcales	P	PFAM Major Facilitator Superfamily	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
TH1_k127_5432099_1	243233.MCA0593	1.003e-90	306.0	COG0515@1|root,COG0631@1|root,COG0515@2|Bacteria,COG0631@2|Bacteria,1MV1P@1224|Proteobacteria,1RNQN@1236|Gammaproteobacteria,1XENA@135618|Methylococcales	135618|Methylococcales	KLT	kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	PP2C_2,Pkinase
TH1_k127_5432693_0	1116472.MGMO_171c00040	1.864e-223	697.0	COG0055@1|root,COG0055@2|Bacteria,1N6UZ@1224|Proteobacteria,1RNQW@1236|Gammaproteobacteria,1XDWQ@135618|Methylococcales	135618|Methylococcales	C	PFAM ATPase, F1 V1 A1 complex, alpha beta subunit, nucleotide-binding domain	-	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
TH1_k127_5432693_1	697282.Mettu_0383	4.132e-46	170.0	COG0355@1|root,COG0355@2|Bacteria,1N1NE@1224|Proteobacteria,1S9B5@1236|Gammaproteobacteria,1XFSN@135618|Methylococcales	135618|Methylococcales	C	ATP synthase, Delta/Epsilon chain, beta-sandwich domain	-	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
TH1_k127_5445013_1	686340.Metal_2274	9.694e-86	313.0	COG2885@1|root,COG2911@1|root,COG2982@1|root,COG2885@2|Bacteria,COG2911@2|Bacteria,COG2982@2|Bacteria,1MUME@1224|Proteobacteria,1RNPC@1236|Gammaproteobacteria,1XE60@135618|Methylococcales	135618|Methylococcales	M	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
TH1_k127_5445013_2	322710.Avin_40140	1.294e-73	255.0	COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,1RS4F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Membrane	yjdF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K08984	-	-	-	-	ko00000	-	-	-	DUF2238
TH1_k127_5445013_0	697282.Mettu_2355	8.076e-143	463.0	28HYC@1|root,2Z83T@2|Bacteria,1QEBM@1224|Proteobacteria,1RRCK@1236|Gammaproteobacteria,1XDJX@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5449736_8	1500894.JQNN01000001_gene3146	0.0004082	44.0	COG1819@1|root,COG1819@2|Bacteria	2|Bacteria	CG	transferase activity, transferring hexosyl groups	-	-	2.4.1.173	ko:K05841	-	-	-	-	ko00000,ko01000,ko01003	-	GT1	-	Glyco_transf_28,UDPGT
TH1_k127_5449736_4	697282.Mettu_1210	8.412e-49	179.0	2DP2V@1|root,330AH@2|Bacteria,1R3EE@1224|Proteobacteria,1T670@1236|Gammaproteobacteria,1XGE6@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF3455)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3455
TH1_k127_5449736_3	686340.Metal_0109	4.306e-98	325.0	COG1028@1|root,COG1028@2|Bacteria,1RHYX@1224|Proteobacteria,1S0GN@1236|Gammaproteobacteria,1XDV0@135618|Methylococcales	135618|Methylococcales	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TH1_k127_5449736_7	1294143.H681_20525	1.165e-17	83.0	COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,1RP7X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodB	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	iAF1260.b1656,iAPECO1_1312.APECO1_736,iB21_1397.B21_01616,iBWG_1329.BWG_1471,iE2348C_1286.E2348C_1742,iEC042_1314.EC042_1825,iEC55989_1330.EC55989_1824,iECABU_c1320.ECABU_c19090,iECBD_1354.ECBD_1987,iECB_1328.ECB_01626,iECDH10B_1368.ECDH10B_1790,iECDH1ME8569_1439.ECDH1ME8569_1601,iECD_1391.ECD_01626,iECED1_1282.ECED1_1855,iECH74115_1262.ECH74115_2368,iECIAI1_1343.ECIAI1_1708,iECO103_1326.ECO103_1797,iECO111_1330.ECO111_2126,iECO26_1355.ECO26_2385,iECOK1_1307.ECOK1_1775,iECP_1309.ECP_1601,iECS88_1305.ECS88_1705,iECSE_1348.ECSE_1780,iECSP_1301.ECSP_2222,iECUMN_1333.ECUMN_1946,iECW_1372.ECW_m1823,iECs_1301.ECs2365,iEKO11_1354.EKO11_2118,iETEC_1333.ETEC_1691,iEcDH1_1363.EcDH1_1984,iEcE24377_1341.EcE24377A_1869,iEcHS_1320.EcHS_A1735,iEcSMS35_1347.EcSMS35_1542,iEcolC_1368.EcolC_1973,iG2583_1286.G2583_2051,iJO1366.b1656,iJR904.b1656,iLF82_1304.LF82_2148,iNRG857_1313.NRG857_08300,iSBO_1134.SBO_1475,iSDY_1059.SDY_1882,iSFV_1184.SFV_1678,iSF_1195.SF1684,iSFxv_1172.SFxv_1892,iSSON_1240.SSON_1500,iS_1188.S1816,iSbBS512_1146.SbBS512_E1853,iUMN146_1321.UM146_08870,iUMNK88_1353.UMNK88_2117,iUTI89_1310.UTI89_C1847,iWFL_1372.ECW_m1823,iY75_1357.Y75_RS08680,iZ_1308.Z2678,ic_1306.c2050	Sod_Fe_C,Sod_Fe_N
TH1_k127_5449736_5	697282.Mettu_1836	3.624e-43	164.0	COG3087@1|root,COG3087@2|Bacteria,1RCC0@1224|Proteobacteria,1SBGX@1236|Gammaproteobacteria,1XF91@135618|Methylococcales	135618|Methylococcales	D	Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
TH1_k127_5449736_0	857087.Metme_4588	1.271e-301	934.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1XENC@135618|Methylococcales	135618|Methylococcales	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
TH1_k127_5449736_2	1380355.JNIJ01000021_gene3727	4.061e-125	412.0	COG2346@1|root,COG3576@1|root,COG2346@2|Bacteria,COG3576@2|Bacteria,1QARU@1224|Proteobacteria,2U2J5@28211|Alphaproteobacteria,3K619@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Bacterial-like globin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin,Putative_PNPOx
TH1_k127_5449736_6	349521.HCH_04640	2.711e-41	174.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1S5PP@1236|Gammaproteobacteria,1XRB8@135619|Oceanospirillales	135619|Oceanospirillales	T	helix_turn_helix, cAMP Regulatory protein	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
TH1_k127_5449736_1	1380355.JNIJ01000021_gene3726	3.3e-130	442.0	COG1018@1|root,COG1018@2|Bacteria,1MY2Q@1224|Proteobacteria,2U0WY@28211|Alphaproteobacteria,3JVZN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Oxidoreductase NAD-binding domain	hcr	-	1.17.1.1	ko:K00523,ko:K21832	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
TH1_k127_5455833_15	882.DVU_2019	5.753e-125	406.0	COG4930@1|root,COG4930@2|Bacteria,1MWGE@1224|Proteobacteria,42N0V@68525|delta/epsilon subdivisions,2WJ2F@28221|Deltaproteobacteria,2M91G@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Putative ATP-dependent Lon protease	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	ChlI,Lon_2,Lon_C,MIT_C
TH1_k127_5455833_0	857087.Metme_3540	0.0	1875.0	28HY3@1|root,2Z83I@2|Bacteria,1R5P3@1224|Proteobacteria,1S1M3@1236|Gammaproteobacteria,1XDZM@135618|Methylococcales	135618|Methylococcales	S	phosphoenolpyruvate carboxykinase (diphosphate) activity	-	-	4.1.1.38	ko:K20370	ko00620,ko01100,map00620,map01100	-	R00346	RC02741	ko00000,ko00001,ko01000	-	-	-	-
TH1_k127_5455833_7	697282.Mettu_2298	3.92e-198	627.0	COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,1RMNC@1236|Gammaproteobacteria,1XE14@135618|Methylococcales	135618|Methylococcales	M	Sporulation related domain	-	-	-	ko:K16291	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	LysM,SPOR,YkuD
TH1_k127_5455833_25	686340.Metal_1385	1.644e-47	176.0	2C0PI@1|root,32VVI@2|Bacteria,1N1H7@1224|Proteobacteria,1T66V@1236|Gammaproteobacteria,1XFRH@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5455833_4	686340.Metal_1384	4.494e-226	705.0	COG3876@1|root,COG3876@2|Bacteria,1MX3S@1224|Proteobacteria,1RSA3@1236|Gammaproteobacteria,1XEB5@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF1343)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1343
TH1_k127_5455833_2	697282.Mettu_2552	7.493e-265	822.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1XDTU@135618|Methylococcales	135618|Methylococcales	H	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
TH1_k127_5455833_19	686340.Metal_2536	1.431e-70	244.0	COG3165@1|root,COG3165@2|Bacteria,1R1CM@1224|Proteobacteria,1S1SM@1236|Gammaproteobacteria,1XF2J@135618|Methylococcales	135618|Methylococcales	S	SCP-2 sterol transfer family	-	-	-	ko:K03690	-	-	-	-	ko00000	-	-	-	SCP2
TH1_k127_5455833_12	857087.Metme_0893	3.739e-141	451.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria,1XEV3@135618|Methylococcales	135618|Methylococcales	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
TH1_k127_5455833_23	857087.Metme_0892	1.034e-53	191.0	COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,1S8TB@1236|Gammaproteobacteria,1XFEV@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF971)	-	-	-	-	-	-	-	-	-	-	-	-	DUF971
TH1_k127_5455833_6	686340.Metal_2533	1.248e-223	699.0	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria,1XE7G@135618|Methylococcales	135618|Methylococcales	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
TH1_k127_5455833_18	1116472.MGMO_175c00050	1.6e-93	309.0	COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,1RP7P@1236|Gammaproteobacteria,1XDWA@135618|Methylococcales	135618|Methylococcales	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
TH1_k127_5455833_1	697282.Mettu_2572	0.0	1098.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1XE70@135618|Methylococcales	135618|Methylococcales	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HTH_12,OB_RNB,RNB,S1
TH1_k127_5455833_17	697282.Mettu_2573	2.022e-104	347.0	COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,1RN2F@1236|Gammaproteobacteria,1XEIJ@135618|Methylococcales	135618|Methylococcales	J	Specifically methylates the ribose of guanosine 2251 in 23S rRNA	rlmB	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
TH1_k127_5455833_28	1116472.MGMO_26c00250	1.017e-27	117.0	2AW4Y@1|root,31MZV@2|Bacteria,1QJRM@1224|Proteobacteria,1THSW@1236|Gammaproteobacteria,1XFKM@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5455833_3	697282.Mettu_0678	1.632e-242	755.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1XDTH@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
TH1_k127_5455833_10	243233.MCA1458	3.861e-148	475.0	COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,1RP2Y@1236|Gammaproteobacteria,1XE38@135618|Methylococcales	135618|Methylococcales	T	PFAM PhoH-like protein	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
TH1_k127_5455833_22	697282.Mettu_0680	8.76e-55	196.0	COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,1S6BS@1236|Gammaproteobacteria,1XFBM@135618|Methylococcales	135618|Methylococcales	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
TH1_k127_5455833_16	857087.Metme_1504	2.827e-111	370.0	COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,1RMKX@1236|Gammaproteobacteria,1XE7Y@135618|Methylococcales	135618|Methylococcales	P	Transporter associated domain	-	-	-	ko:K06189	-	-	-	-	ko00000,ko02000	9.A.40.1.2	-	-	CBS,CorC_HlyC
TH1_k127_5455833_9	857087.Metme_2452	1.145e-154	495.0	COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,1RMTU@1236|Gammaproteobacteria,1XEJ2@135618|Methylococcales	135618|Methylococcales	M	epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
TH1_k127_5455833_14	697282.Mettu_2838	1.223e-134	434.0	COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,1RNDX@1236|Gammaproteobacteria,1XECY@135618|Methylococcales	135618|Methylococcales	M	UTP-glucose-1-phosphate uridylyltransferase	-	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TH1_k127_5455833_21	697282.Mettu_3210	9.118e-56	201.0	2AUFG@1|root,31K3K@2|Bacteria,1QHXC@1224|Proteobacteria,1TFNZ@1236|Gammaproteobacteria,1XF8U@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5455833_24	349521.HCH_01554	3.706e-48	178.0	COG3122@1|root,COG3122@2|Bacteria,1N15V@1224|Proteobacteria,1S5V0@1236|Gammaproteobacteria,1XKK5@135619|Oceanospirillales	135619|Oceanospirillales	S	protein conserved in bacteria	-	-	-	ko:K09912	-	-	-	-	ko00000	-	-	-	DUF2058
TH1_k127_5455833_30	1249627.D779_3899	7.684e-14	73.0	COG3118@1|root,COG3118@2|Bacteria,1RHUA@1224|Proteobacteria,1S64W@1236|Gammaproteobacteria,1WYAU@135613|Chromatiales	135613|Chromatiales	O	TIGRFAM Thioredoxin	-	-	1.8.1.8	ko:K03672	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Thioredoxin
TH1_k127_5455833_27	365044.Pnap_2221	4.652e-29	119.0	COG0789@1|root,COG0789@2|Bacteria,1N9MT@1224|Proteobacteria,2VVPZ@28216|Betaproteobacteria	28216|Betaproteobacteria	K	MerR HTH family regulatory protein	-	-	-	ko:K18997	-	-	-	-	ko00000,ko03036	-	-	-	MerR_2
TH1_k127_5455833_13	1049564.TevJSym_af00130	1.287e-135	437.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,1RP09@1236|Gammaproteobacteria,1J5VE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	DnaJ-class molecular chaperone	cbpA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0097159,GO:1901363	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
TH1_k127_5455833_5	697282.Mettu_2585	4.796e-225	706.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,1XDY2@135618|Methylococcales	135618|Methylococcales	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
TH1_k127_5455833_31	686340.Metal_1413	3.288e-08	63.0	2B1M3@1|root,31U2J@2|Bacteria,1QRW4@1224|Proteobacteria,1THVR@1236|Gammaproteobacteria,1XFUM@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5455833_20	697282.Mettu_0718	1.026e-57	207.0	2E7NN@1|root,3324C@2|Bacteria,1NA2Z@1224|Proteobacteria,1SVUS@1236|Gammaproteobacteria,1XFCU@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5455833_26	857087.Metme_2190	1.664e-34	138.0	2AWEU@1|root,31NAX@2|Bacteria,1QK1Z@1224|Proteobacteria,1TI4I@1236|Gammaproteobacteria,1XGH9@135618|Methylococcales	135618|Methylococcales	S	Beta/Gamma crystallin	-	-	-	-	-	-	-	-	-	-	-	-	Crystall_3
TH1_k127_5455833_8	686340.Metal_2200	1.118e-179	577.0	2C6BE@1|root,32XBJ@2|Bacteria,1NB89@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5455833_11	1089544.KB912942_gene1762	6.389e-147	483.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria,4E0F3@85010|Pseudonocardiales	201174|Actinobacteria	G	PEP-utilising enzyme, mobile domain	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
TH1_k127_5455833_29	292415.Tbd_0367	1.121e-17	91.0	COG1392@1|root,COG1392@2|Bacteria,1MW5V@1224|Proteobacteria,2VM9A@28216|Betaproteobacteria,1KRYF@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Phosphate transport regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5462533_7	640081.Dsui_0468	4.394e-07	53.0	COG0438@1|root,COG0438@2|Bacteria,1NE3V@1224|Proteobacteria,2VJET@28216|Betaproteobacteria,2KUQ5@206389|Rhodocyclales	206389|Rhodocyclales	M	Glycosyl transferases group 1	-	-	-	ko:K02844	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT4	-	Glyco_transf_4,Glycos_transf_1
TH1_k127_5462533_3	1123487.KB892857_gene2355	1.969e-101	342.0	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,2VRSM@28216|Betaproteobacteria,2KVQV@206389|Rhodocyclales	206389|Rhodocyclales	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02849	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
TH1_k127_5462533_4	1122604.JONR01000037_gene4238	1.116e-83	284.0	COG0463@1|root,COG0463@2|Bacteria,1PVP4@1224|Proteobacteria,1RQUH@1236|Gammaproteobacteria,1X51A@135614|Xanthomonadales	135614|Xanthomonadales	M	COG0463 Glycosyltransferases involved in cell wall biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TH1_k127_5462533_1	686340.Metal_0855	6.411e-127	410.0	2CCJR@1|root,2ZCU4@2|Bacteria,1RC7F@1224|Proteobacteria,1S3JC@1236|Gammaproteobacteria,1XDT3@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5462533_6	697282.Mettu_1862	3.446e-46	170.0	COG1238@1|root,COG1238@2|Bacteria,1RHUV@1224|Proteobacteria,1SCPK@1236|Gammaproteobacteria,1XFAV@135618|Methylococcales	135618|Methylococcales	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5462533_2	857087.Metme_0453	1.111e-108	359.0	COG3794@1|root,COG3794@2|Bacteria,1RFFF@1224|Proteobacteria,1SN7W@1236|Gammaproteobacteria,1XDM9@135618|Methylococcales	135618|Methylococcales	C	PFAM multicopper oxidase type 2	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5462533_5	686340.Metal_0852	1.959e-60	214.0	2E6CY@1|root,3310K@2|Bacteria,1NFYR@1224|Proteobacteria,1SIZ7@1236|Gammaproteobacteria,1XERQ@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5462533_0	697282.Mettu_1865	3.68e-266	830.0	COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,1RNIT@1236|Gammaproteobacteria,1XEDN@135618|Methylococcales	135618|Methylococcales	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
TH1_k127_55173_4	1132855.KB913035_gene780	2.189e-143	462.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,2VICS@28216|Betaproteobacteria,2KKMV@206350|Nitrosomonadales	206350|Nitrosomonadales	H	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	cysG	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
TH1_k127_55173_11	857087.Metme_3718	1.162e-31	128.0	COG2010@1|root,COG2010@2|Bacteria,1P89P@1224|Proteobacteria,1STPI@1236|Gammaproteobacteria,1XFEX@135618|Methylococcales	135618|Methylococcales	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_55173_13	697282.Mettu_0347	2.457e-25	106.0	2DNYP@1|root,32ZTI@2|Bacteria,1N747@1224|Proteobacteria,1SCCQ@1236|Gammaproteobacteria,1XFTW@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF2905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2905
TH1_k127_55173_9	1116472.MGMO_52c00080	1.001e-50	188.0	2AW1M@1|root,31MW7@2|Bacteria,1QJNA@1224|Proteobacteria,1THP1@1236|Gammaproteobacteria,1XF4N@135618|Methylococcales	135618|Methylococcales	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
TH1_k127_55173_0	1116472.MGMO_137c00030	1.063e-278	861.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1XDV5@135618|Methylococcales	135618|Methylococcales	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
TH1_k127_55173_10	472759.Nhal_1738	6.332e-37	141.0	COG4634@1|root,COG4634@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_55173_12	472759.Nhal_1737	5.141e-28	114.0	COG2442@1|root,COG2442@2|Bacteria,1N8Z1@1224|Proteobacteria,1SC0G@1236|Gammaproteobacteria,1WZ65@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
TH1_k127_55173_6	697282.Mettu_2581	1.296e-113	372.0	COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,1RSP8@1236|Gammaproteobacteria,1XG94@135618|Methylococcales	135618|Methylococcales	S	OST-HTH/LOTUS domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
TH1_k127_55173_3	686340.Metal_0403	4.577e-178	563.0	COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,1RP9Z@1236|Gammaproteobacteria,1XDX7@135618|Methylococcales	135618|Methylococcales	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
TH1_k127_55173_1	686340.Metal_0168	5.016e-231	733.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,1RQ4N@1236|Gammaproteobacteria,1XG3Q@135618|Methylococcales	135618|Methylococcales	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
TH1_k127_55173_7	686340.Metal_0169	8.868e-111	363.0	COG3667@1|root,COG3667@2|Bacteria,1MXW6@1224|Proteobacteria,1RZEY@1236|Gammaproteobacteria,1XGPQ@135618|Methylococcales	135618|Methylococcales	P	Copper resistance protein B precursor (CopB)	-	-	-	-	-	-	-	-	-	-	-	-	CopB
TH1_k127_55173_5	1116472.MGMO_60c00390	2.241e-115	384.0	COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,1RN1U@1236|Gammaproteobacteria,1XE6R@135618|Methylococcales	135618|Methylococcales	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
TH1_k127_55173_8	697282.Mettu_0836	6.839e-73	246.0	COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,1THNZ@1236|Gammaproteobacteria,1XF4B@135618|Methylococcales	135618|Methylococcales	S	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
TH1_k127_55173_2	857087.Metme_3767	1.015e-206	659.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1XE2S@135618|Methylococcales	135618|Methylococcales	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
TH1_k127_5532279_0	1116472.MGMO_2c00010	2.011e-123	404.0	COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,1XECB@135618|Methylococcales	135618|Methylococcales	M	TIGRFAM Lytic murein transglycosylase B	-	-	-	ko:K08305	-	-	-	-	ko00000,ko01000,ko01011	-	GH103	-	SLT_2
TH1_k127_5532279_1	697282.Mettu_4350	8.792e-120	394.0	COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,1RMDU@1236|Gammaproteobacteria,1XEAP@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
TH1_k127_5532279_2	686340.Metal_1014	4.224e-117	383.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1XDJ5@135618|Methylococcales	135618|Methylococcales	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
TH1_k127_5555686_4	697282.Mettu_3799	8.85e-85	284.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1XE9Y@135618|Methylococcales	135618|Methylococcales	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
TH1_k127_5555686_3	686340.Metal_0699	3.395e-180	570.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,1RN22@1236|Gammaproteobacteria,1XDK4@135618|Methylococcales	135618|Methylococcales	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
TH1_k127_5555686_6	686340.Metal_0698	2.149e-54	192.0	COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,1S3P3@1236|Gammaproteobacteria,1XF6T@135618|Methylococcales	135618|Methylococcales	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
TH1_k127_5555686_7	1116472.MGMO_41c00390	6.391e-28	116.0	COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,1SCHI@1236|Gammaproteobacteria,1XFG5@135618|Methylococcales	135618|Methylococcales	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
TH1_k127_5555686_5	857087.Metme_1718	2.209e-80	270.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,1S4E6@1236|Gammaproteobacteria,1XF2T@135618|Methylococcales	135618|Methylococcales	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
TH1_k127_5555686_0	697282.Mettu_3794	0.0	1106.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,1XDMC@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
TH1_k127_5555686_1	857087.Metme_2971	0.0	1088.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1XED2@135618|Methylococcales	135618|Methylococcales	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
TH1_k127_5555686_2	857087.Metme_2593	2.203e-192	606.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNN0@1236|Gammaproteobacteria,1XE5B@135618|Methylococcales	135618|Methylococcales	E	PFAM Aminotransferase, class I	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TH1_k127_5555686_8	1116472.MGMO_143c00040	1.996e-25	111.0	2B6TC@1|root,31ZSM@2|Bacteria,1QK6A@1224|Proteobacteria,1TI9J@1236|Gammaproteobacteria,1XGTJ@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5559660_2	1116472.MGMO_10c00050	3.082e-32	126.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1XDSC@135618|Methylococcales	135618|Methylococcales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
TH1_k127_5559660_1	1116472.MGMO_10c00070	9.225e-42	156.0	29FX1@1|root,34453@2|Bacteria,1P3CX@1224|Proteobacteria,1SVJS@1236|Gammaproteobacteria,1XGJE@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5559660_0	1268635.Loa_01295	9.694e-94	324.0	COG1538@1|root,COG1538@2|Bacteria,1PCPQ@1224|Proteobacteria,1RRRP@1236|Gammaproteobacteria,1JCMG@118969|Legionellales	118969|Legionellales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TH1_k127_55720_2	686340.Metal_3979	1.625e-79	269.0	COG2271@1|root,COG2271@2|Bacteria,1MUEK@1224|Proteobacteria,1RMB4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Major facilitator superfamily	ttuB	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TH1_k127_55720_1	697282.Mettu_0759	5.955e-188	594.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RND5@1236|Gammaproteobacteria,1XDU0@135618|Methylococcales	135618|Methylococcales	C	TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6	-	-	-	ko:K03184	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R06146,R08775	RC01254	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
TH1_k127_55720_0	243233.MCA2039	0.0	2243.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1XEDS@135618|Methylococcales	135618|Methylococcales	E	Glutamate synthase	gltB	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
TH1_k127_5606880_2	95619.PM1_0205145	1.222e-13	72.0	COG3008@1|root,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,1RN89@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	paraquat-inducible protein b	yebT	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006869,GO:0008150,GO:0009987,GO:0010876,GO:0016020,GO:0016021,GO:0016043,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0033036,GO:0042597,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071840,GO:0071944,GO:0120009	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
TH1_k127_5606880_1	857087.Metme_2845	3.704e-34	134.0	COG1923@1|root,COG1923@2|Bacteria,1MZM1@1224|Proteobacteria,1S8W0@1236|Gammaproteobacteria,1XFJK@135618|Methylococcales	135618|Methylococcales	J	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs	hfq	-	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
TH1_k127_5606880_0	686340.Metal_2921	6.694e-160	508.0	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria,1XDYP@135618|Methylococcales	135618|Methylococcales	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
TH1_k127_5644808_2	697282.Mettu_1758	2.251e-12	68.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,1XFYN@135618|Methylococcales	135618|Methylococcales	C	Cysteine-rich domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_8
TH1_k127_5644808_0	686340.Metal_1349	1.466e-186	585.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,1RR0T@1236|Gammaproteobacteria,1XG8N@135618|Methylococcales	135618|Methylococcales	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
TH1_k127_5644808_1	697282.Mettu_1758	8.633e-24	101.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,1XFYN@135618|Methylococcales	135618|Methylococcales	C	Cysteine-rich domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_8
TH1_k127_570335_3	686340.Metal_1174	1.052e-26	109.0	2CDMX@1|root,32S1K@2|Bacteria,1N1I8@1224|Proteobacteria,1S9N4@1236|Gammaproteobacteria,1XFN4@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_570335_4	1120970.AUBZ01000001_gene3665	2.387e-24	105.0	COG3098@1|root,COG3098@2|Bacteria,1N7AG@1224|Proteobacteria,1SCXJ@1236|Gammaproteobacteria,468CS@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	yqcC	GO:0008150,GO:0009987,GO:0042710,GO:0044010,GO:0044764,GO:0051704	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF446
TH1_k127_570335_0	697282.Mettu_4256	1.785e-130	424.0	COG3391@1|root,COG3391@2|Bacteria,1MXJJ@1224|Proteobacteria,1SZ16@1236|Gammaproteobacteria,1XE8Q@135618|Methylococcales	135618|Methylococcales	S	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Lactonase
TH1_k127_570335_1	686340.Metal_1172	3.124e-69	240.0	COG3832@1|root,COG3832@2|Bacteria,1RD9A@1224|Proteobacteria,1S95U@1236|Gammaproteobacteria,1XF1E@135618|Methylococcales	135618|Methylococcales	S	PFAM Polyketide cyclase dehydrase	-	-	-	ko:K16260	ko00680,ko01120,map00680,map01120	-	-	-	ko00000,ko00001	-	-	-	Polyketide_cyc2
TH1_k127_570335_6	1469607.KK073769_gene5954	3.664e-05	51.0	COG3415@1|root,COG3415@2|Bacteria,1GAAQ@1117|Cyanobacteria	1117|Cyanobacteria	L	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_28,HTH_33
TH1_k127_570335_5	1116472.MGMO_146c00070	9.82e-14	72.0	COG2833@1|root,COG2833@2|Bacteria,1MW0V@1224|Proteobacteria,1RNGA@1236|Gammaproteobacteria,1XEPF@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF455)	-	-	-	-	-	-	-	-	-	-	-	-	DUF455
TH1_k127_570335_2	388467.A19Y_2489	3.211e-31	126.0	COG3744@1|root,COG3744@2|Bacteria,1G89C@1117|Cyanobacteria,1HCPH@1150|Oscillatoriales	1117|Cyanobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TH1_k127_57419_0	697282.Mettu_0058	4.77e-181	575.0	COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,1XE2C@135618|Methylococcales	135618|Methylococcales	KL	HELICc2	-	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2
TH1_k127_57419_4	697282.Mettu_0059	3.152e-85	287.0	COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,1RPYX@1236|Gammaproteobacteria,1XDV7@135618|Methylococcales	135618|Methylococcales	O	Glycoprotease family	-	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
TH1_k127_57419_3	697282.Mettu_2566	1.247e-94	314.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1RNU8@1236|Gammaproteobacteria,1XDVQ@135618|Methylococcales	135618|Methylococcales	J	Belongs to the SUA5 family	-	-	-	-	-	-	-	-	-	-	-	-	Sua5_yciO_yrdC
TH1_k127_57419_1	686340.Metal_3704	2.648e-107	350.0	COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,1S4N8@1236|Gammaproteobacteria,1XE0T@135618|Methylococcales	135618|Methylococcales	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_57419_2	697282.Mettu_2568	8.003e-106	351.0	COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,1RNBB@1236|Gammaproteobacteria,1XEA4@135618|Methylococcales	135618|Methylococcales	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
TH1_k127_5745485_1	857087.Metme_1905	1.932e-57	201.0	COG0204@1|root,COG3176@1|root,COG0204@2|Bacteria,COG3176@2|Bacteria,1MWIM@1224|Proteobacteria,1RZYE@1236|Gammaproteobacteria,1XE9W@135618|Methylococcales	135618|Methylococcales	I	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_5
TH1_k127_5745485_4	926569.ANT_23550	5.384e-10	63.0	COG0859@1|root,COG0859@2|Bacteria	2|Bacteria	M	ADP-heptose-lipopolysaccharide heptosyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9,Methyltransf_14
TH1_k127_5745485_0	686340.Metal_3270	1.855e-78	270.0	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,1RMW5@1236|Gammaproteobacteria,1XENE@135618|Methylococcales	135618|Methylococcales	P	Plays a role in the regulation of phosphate uptake	-	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
TH1_k127_5745485_3	697282.Mettu_4144	3.972e-27	112.0	COG1183@1|root,COG1183@2|Bacteria,1MYK9@1224|Proteobacteria,1SFHY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
TH1_k127_5745485_2	377629.TERTU_1841	1.655e-39	153.0	COG0469@1|root,COG0469@2|Bacteria,1NNNX@1224|Proteobacteria,1RYF5@1236|Gammaproteobacteria,2PPWP@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	G	Pyruvate kinase, barrel domain	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK
TH1_k127_5752668_2	1116472.MGMO_120c00350	6.933e-16	77.0	COG3520@1|root,COG3520@2|Bacteria,1MWVS@1224|Proteobacteria,1RQD5@1236|Gammaproteobacteria,1XEN8@135618|Methylococcales	135618|Methylococcales	S	Type VI secretion, TssG	-	-	-	ko:K11895	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	T6SS_TssG
TH1_k127_5752668_0	1116472.MGMO_120c00340	0.0	1467.0	COG0542@1|root,COG0542@2|Bacteria,1MVBH@1224|Proteobacteria,1RMZH@1236|Gammaproteobacteria,1XEXC@135618|Methylococcales	135618|Methylococcales	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	ko:K11907	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	AAA,AAA_2,ClpB_D2-small
TH1_k127_5752668_1	1116472.MGMO_120c00330	2.839e-291	903.0	COG3501@1|root,COG3501@2|Bacteria,1MU7Q@1224|Proteobacteria,1RMZS@1236|Gammaproteobacteria,1XEX4@135618|Methylococcales	135618|Methylococcales	S	Phage late control gene D protein (GPD)	-	-	-	ko:K11904	ko03070,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	Phage_GPD
TH1_k127_5754925_0	1278309.KB907104_gene879	1.673e-172	554.0	COG0330@1|root,COG0330@2|Bacteria,1R93I@1224|Proteobacteria,1RPTI@1236|Gammaproteobacteria,1XINU@135619|Oceanospirillales	135619|Oceanospirillales	O	SPFH domain / Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
TH1_k127_5754925_3	1288494.EBAPG3_12530	1.438e-30	123.0	2A022@1|root,314J6@2|Bacteria,1PU9G@1224|Proteobacteria,2WARG@28216|Betaproteobacteria,373H9@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Domain of unknown function (DUF1840)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1840
TH1_k127_5754925_4	243233.MCA0552	5.552e-21	94.0	2F1EJ@1|root,33UF9@2|Bacteria,1NV3G@1224|Proteobacteria,1TI1Z@1236|Gammaproteobacteria,1XGBM@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5760319_3	1116472.MGMO_86c00050	3.325e-36	142.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,1XDU7@135618|Methylococcales	135618|Methylococcales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
TH1_k127_5760319_0	697282.Mettu_2694	1.319e-255	801.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,1XDXB@135618|Methylococcales	135618|Methylococcales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD-TM1,SecD_SecF,Sec_GG
TH1_k127_5760319_2	857087.Metme_3938	1.322e-44	166.0	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,1S9NV@1236|Gammaproteobacteria,1XFBY@135618|Methylococcales	135618|Methylococcales	U	Preprotein translocase subunit	-	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
TH1_k127_5760319_1	697282.Mettu_2692	7.899e-138	441.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,1RMY3@1236|Gammaproteobacteria,1XE0N@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
TH1_k127_5781699_2	697282.Mettu_3553	7.286e-70	243.0	COG0560@1|root,COG0560@2|Bacteria,1PIND@1224|Proteobacteria,1S9GK@1236|Gammaproteobacteria,1XEK5@135618|Methylococcales	135618|Methylococcales	E	haloacid dehalogenase-like hydrolase	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD
TH1_k127_5781699_0	697282.Mettu_3552	5.924e-117	380.0	COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,1RP5N@1236|Gammaproteobacteria,1XDV4@135618|Methylococcales	135618|Methylococcales	K	transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
TH1_k127_5781699_3	857087.Metme_1487	1.826e-68	235.0	COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,1RQPJ@1236|Gammaproteobacteria,1XF1A@135618|Methylococcales	135618|Methylococcales	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
TH1_k127_5781699_1	686340.Metal_2813	2.464e-83	282.0	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,1RMET@1236|Gammaproteobacteria,1XEQU@135618|Methylococcales	135618|Methylococcales	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
TH1_k127_5781699_4	686340.Metal_2814	1.588e-67	233.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria,1XDQ4@135618|Methylococcales	135618|Methylococcales	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
TH1_k127_5793934_5	857087.Metme_3058	9.583e-48	173.0	COG0847@1|root,COG0847@2|Bacteria,1MUPK@1224|Proteobacteria,1RMMH@1236|Gammaproteobacteria,1XE01@135618|Methylococcales	135618|Methylococcales	L	Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis	rnt	-	-	ko:K03683	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_T
TH1_k127_5793934_4	697282.Mettu_2882	7.748e-48	174.0	COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,1S640@1236|Gammaproteobacteria,1XFF2@135618|Methylococcales	135618|Methylococcales	C	Belongs to the glutaredoxin family. Monothiol subfamily	-	-	-	ko:K07390	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Glutaredoxin
TH1_k127_5793934_1	697282.Mettu_0782	1.143e-179	573.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria,1XECU@135618|Methylococcales	135618|Methylococcales	E	PFAM Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TH1_k127_5793934_2	697282.Mettu_0783	4.083e-149	476.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,1RQ59@1236|Gammaproteobacteria,1XE28@135618|Methylococcales	135618|Methylococcales	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	-	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
TH1_k127_5793934_3	857087.Metme_2558	4.383e-58	211.0	COG2433@1|root,COG2433@2|Bacteria,1QWB7@1224|Proteobacteria,1T3FV@1236|Gammaproteobacteria,1XF8E@135618|Methylococcales	135618|Methylococcales	S	Bacterial SH3 domain homologues	-	-	-	ko:K07184	-	-	-	-	ko00000	-	-	-	SH3_3
TH1_k127_5793934_0	697282.Mettu_0785	5.187e-207	649.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,1XESA@135618|Methylococcales	135618|Methylococcales	H	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
TH1_k127_5832750_18	697282.Mettu_3019	2.762e-14	75.0	COG0275@1|root,COG0275@2|Bacteria,1R1HD@1224|Proteobacteria,1SBTJ@1236|Gammaproteobacteria,1XFDV@135618|Methylococcales	135618|Methylococcales	M	rRNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	rRNA_methylase
TH1_k127_5832750_9	595460.RRSWK_00757	5.791e-93	314.0	COG1305@1|root,COG1305@2|Bacteria,2IY1Q@203682|Planctomycetes	203682|Planctomycetes	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
TH1_k127_5832750_14	1116472.MGMO_216c00030	4.679e-38	144.0	2CUP7@1|root,32SVQ@2|Bacteria,1QJVN@1224|Proteobacteria,1THXA@1236|Gammaproteobacteria,1XFY4@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5832750_0	686340.Metal_2986	1.938e-260	809.0	COG1541@1|root,COG1541@2|Bacteria,1R8T9@1224|Proteobacteria,1S1JC@1236|Gammaproteobacteria,1XEUW@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	-
TH1_k127_5832750_17	317936.Nos7107_1803	1.078e-14	78.0	2CFW7@1|root,32S2M@2|Bacteria,1G83P@1117|Cyanobacteria,1HPE5@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5832750_1	1116472.MGMO_122c00030	5.571e-234	734.0	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,1RMEC@1236|Gammaproteobacteria,1XEJG@135618|Methylococcales	135618|Methylococcales	F	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
TH1_k127_5832750_15	857087.Metme_3719	7.17e-32	133.0	2AUHS@1|root,31K65@2|Bacteria,1QI00@1224|Proteobacteria,1TFSE@1236|Gammaproteobacteria,1XFCB@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_5832750_16	686340.Metal_0905	1.296e-22	98.0	COG1977@1|root,COG1977@2|Bacteria,1NHG7@1224|Proteobacteria,1TG6J@1236|Gammaproteobacteria,1XFT3@135618|Methylococcales	135618|Methylococcales	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	moaD	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
TH1_k127_5832750_13	697282.Mettu_2395	4.278e-58	206.0	COG0314@1|root,COG0314@2|Bacteria,1RGUX@1224|Proteobacteria,1S5YH@1236|Gammaproteobacteria,1XFC1@135618|Methylococcales	135618|Methylococcales	H	MoaE protein	moaE	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
TH1_k127_5832750_8	1026882.MAMP_02394	2.253e-97	321.0	COG1795@1|root,COG1795@2|Bacteria,1MWYS@1224|Proteobacteria,1S3E5@1236|Gammaproteobacteria,461JV@72273|Thiotrichales	72273|Thiotrichales	S	PFAM Formaldehyde-activating enzyme (Fae)	-	-	-	-	-	-	-	-	-	-	-	-	Fae
TH1_k127_5832750_12	697282.Mettu_0642	7.943e-68	233.0	COG1051@1|root,COG1051@2|Bacteria,1N03W@1224|Proteobacteria,1S970@1236|Gammaproteobacteria,1XF6X@135618|Methylococcales	135618|Methylococcales	F	Belongs to the Nudix hydrolase family. NudJ subfamily	nudJ	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TH1_k127_5832750_5	1283300.ATXB01000001_gene225	4.793e-168	534.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,1RMAK@1236|Gammaproteobacteria,1XDMP@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
TH1_k127_5832750_10	857087.Metme_0534	9.992e-77	259.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,1S3ST@1236|Gammaproteobacteria,1XF23@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
TH1_k127_5832750_11	686340.Metal_3702	1.448e-70	244.0	COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,1RNXE@1236|Gammaproteobacteria,1XDQ9@135618|Methylococcales	135618|Methylococcales	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
TH1_k127_5832750_7	686340.Metal_3701	3.093e-118	390.0	COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,1RQU0@1236|Gammaproteobacteria,1XEEG@135618|Methylococcales	135618|Methylococcales	J	Belongs to the pseudouridine synthase RsuA family	-	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TH1_k127_5832750_2	1000565.METUNv1_01353	2.383e-213	665.0	COG1089@1|root,COG1089@2|Bacteria,1MUX0@1224|Proteobacteria,2VIBX@28216|Betaproteobacteria,2KVB6@206389|Rhodocyclales	206389|Rhodocyclales	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
TH1_k127_5832750_6	864051.BurJ1DRAFT_1271	7.151e-146	467.0	COG0451@1|root,COG0451@2|Bacteria,1MUGT@1224|Proteobacteria,2VK2N@28216|Betaproteobacteria,1KIT7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction	fcl	-	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R05692	RC01014	ko00000,ko00001,ko01000	-	-	-	Epimerase
TH1_k127_5832750_4	697282.Mettu_4200	4.279e-173	555.0	COG1109@1|root,COG1109@2|Bacteria,1MUB3@1224|Proteobacteria,1RNFZ@1236|Gammaproteobacteria,1XEA7@135618|Methylococcales	135618|Methylococcales	G	PFAM Alpha-D-phosphohexomutase, alpha beta alpha domain I	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TH1_k127_5832750_3	1288494.EBAPG3_29530	4.222e-192	611.0	COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,2VI4S@28216|Betaproteobacteria,371YG@32003|Nitrosomonadales	28216|Betaproteobacteria	M	TIGRFAM Mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase	cpsB	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
TH1_k127_5834532_0	686340.Metal_2168	1.235e-216	687.0	COG2211@1|root,COG2211@2|Bacteria,1MWSH@1224|Proteobacteria,1S124@1236|Gammaproteobacteria,1XEG3@135618|Methylococcales	135618|Methylococcales	G	BT1 family	-	-	-	-	-	-	-	-	-	-	-	-	BT1
TH1_k127_5901930_3	697282.Mettu_2905	9.48e-06	50.0	COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,1RPWB@1236|Gammaproteobacteria,1XEWJ@135618|Methylococcales	135618|Methylococcales	S	Belongs to the GcvT family	-	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T
TH1_k127_5901930_2	1149133.ppKF707_0637	7.623e-65	226.0	COG1943@1|root,COG1943@2|Bacteria,1RCWW@1224|Proteobacteria,1S3ZJ@1236|Gammaproteobacteria,1YGAN@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
TH1_k127_5901930_1	1116472.MGMO_61c00100	7.722e-71	246.0	COG1266@1|root,COG1266@2|Bacteria,1RI59@1224|Proteobacteria,1S8JI@1236|Gammaproteobacteria,1XF1F@135618|Methylococcales	135618|Methylococcales	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
TH1_k127_5901930_0	697282.Mettu_1901	6.501e-110	357.0	COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,1RMCD@1236|Gammaproteobacteria,1XDV2@135618|Methylococcales	135618|Methylococcales	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
TH1_k127_590608_0	697282.Mettu_3920	3.695e-257	799.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria,1XDN9@135618|Methylococcales	135618|Methylococcales	I	Domain of unknown function (DUF1974)	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N,DUF1974
TH1_k127_593619_0	697282.Mettu_0561	9.793e-169	533.0	28HK0@1|root,2Z7V0@2|Bacteria,1MXSJ@1224|Proteobacteria,1RRAP@1236|Gammaproteobacteria,1XG88@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF4105)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4105
TH1_k127_593619_1	857087.Metme_3144	2.564e-136	445.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1RYHN@1236|Gammaproteobacteria,1XDM2@135618|Methylococcales	135618|Methylococcales	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
TH1_k127_593619_2	857087.Metme_3143	5.097e-133	427.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,1XG96@135618|Methylococcales	135618|Methylococcales	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
TH1_k127_593619_3	857087.Metme_3142	3.485e-37	144.0	COG1463@1|root,COG1463@2|Bacteria,1Q6ZU@1224|Proteobacteria,1S6SW@1236|Gammaproteobacteria,1XGZV@135618|Methylococcales	135618|Methylococcales	Q	MlaD protein	-	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
TH1_k127_5970526_3	697282.Mettu_0890	3.567e-62	216.0	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,1RMGN@1236|Gammaproteobacteria,1XDKH@135618|Methylococcales	135618|Methylococcales	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
TH1_k127_5970526_2	697282.Mettu_0891	1.279e-150	481.0	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,1RNDS@1236|Gammaproteobacteria,1XDUU@135618|Methylococcales	135618|Methylococcales	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
TH1_k127_5970526_1	697282.Mettu_0892	1.507e-174	556.0	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,1RMB0@1236|Gammaproteobacteria,1XEPM@135618|Methylococcales	135618|Methylococcales	H	PFAM Mur ligase	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
TH1_k127_5970526_5	697282.Mettu_0893	9.219e-25	115.0	COG3147@1|root,COG3147@2|Bacteria,1NGE3@1224|Proteobacteria,1SCGC@1236|Gammaproteobacteria,1XFK1@135618|Methylococcales	135618|Methylococcales	S	Sporulation related domain	-	-	-	ko:K03749	-	-	-	-	ko00000	-	-	-	SPOR
TH1_k127_5970526_4	857087.Metme_0610	9.086e-57	203.0	COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,1RQ58@1236|Gammaproteobacteria,1XFN7@135618|Methylococcales	135618|Methylococcales	S	PFAM Colicin V production protein	-	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
TH1_k127_5970526_0	857087.Metme_0611	7.481e-237	737.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,1XETA@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,Pribosyltran
TH1_k127_600633_6	1123257.AUFV01000003_gene827	0.0007364	48.0	COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,1RP5U@1236|Gammaproteobacteria,1X4K1@135614|Xanthomonadales	135614|Xanthomonadales	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
TH1_k127_600633_4	686340.Metal_2522	2.158e-77	267.0	COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,1XDJA@135618|Methylococcales	135618|Methylococcales	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
TH1_k127_600633_2	697282.Mettu_0744	6.157e-99	329.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1T1HN@1236|Gammaproteobacteria,1XDWI@135618|Methylococcales	135618|Methylococcales	V	pfam abc	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TH1_k127_600633_3	686340.Metal_2524	1.534e-84	284.0	COG2915@1|root,COG2915@2|Bacteria,1RI8B@1224|Proteobacteria,1RPCC@1236|Gammaproteobacteria,1XEPZ@135618|Methylococcales	135618|Methylococcales	S	High frequency lysogenization protein HflD homolog	hflD	-	-	ko:K07153	-	-	-	-	ko00000	-	-	-	DUF489
TH1_k127_600633_5	686340.Metal_2525	2.566e-15	77.0	COG2608@1|root,COG2608@2|Bacteria,1NGBD@1224|Proteobacteria,1THV1@1236|Gammaproteobacteria,1XFT4@135618|Methylococcales	135618|Methylococcales	C	Heavy-metal-associated domain	-	-	-	ko:K07213	ko04978,map04978	-	-	-	ko00000,ko00001	-	-	-	HMA
TH1_k127_600633_0	697282.Mettu_0748	0.0	1054.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1XDZ2@135618|Methylococcales	135618|Methylococcales	P	ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
TH1_k127_600633_1	857087.Metme_3258	4.764e-117	384.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008964,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0072350	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	iSFV_1184.SFV_4025	PEPcase
TH1_k127_6022558_5	697282.Mettu_1604	1.172e-112	379.0	COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R9Q1@1224|Proteobacteria,1RSKD@1236|Gammaproteobacteria,1XEBR@135618|Methylococcales	135618|Methylococcales	PT	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,cNMP_binding
TH1_k127_6022558_6	697282.Mettu_2343	1.259e-55	198.0	COG1585@1|root,COG1585@2|Bacteria,1N241@1224|Proteobacteria,1S5W4@1236|Gammaproteobacteria,1XFBP@135618|Methylococcales	135618|Methylococcales	OU	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07340	-	-	-	-	ko00000	-	-	-	NfeD
TH1_k127_6022558_3	857087.Metme_0294	1.48e-146	469.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,1RNW8@1236|Gammaproteobacteria,1XEH8@135618|Methylococcales	135618|Methylococcales	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
TH1_k127_6022558_7	697282.Mettu_2345	5.25e-12	70.0	2BHCG@1|root,32BE5@2|Bacteria,1QJTG@1224|Proteobacteria,1THUR@1236|Gammaproteobacteria,1XFSJ@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_6022558_1	697282.Mettu_0781	1.589e-165	525.0	COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,1XEKQ@135618|Methylococcales	135618|Methylococcales	H	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX	hemF	GO:0003674,GO:0003824,GO:0004109,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016634,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042802,GO:0042803,GO:0044237,GO:0044249,GO:0044271,GO:0046483,GO:0046983,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	-	Coprogen_oxidas
TH1_k127_6022558_4	697282.Mettu_2543	1.128e-142	465.0	COG0500@1|root,COG0500@2|Bacteria,1MVSK@1224|Proteobacteria,1RMQY@1236|Gammaproteobacteria,1XEHT@135618|Methylococcales	135618|Methylococcales	J	Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs	cmoB	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_9
TH1_k127_6022558_0	697282.Mettu_0016	5.196e-247	766.0	COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,1RN46@1236|Gammaproteobacteria,1XE6C@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,UPF0004
TH1_k127_6022558_2	697282.Mettu_2391	1.335e-151	486.0	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,1XDVU@135618|Methylococcales	135618|Methylococcales	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
TH1_k127_6022558_8	768671.ThimaDRAFT_4911	5.441e-05	46.0	COG5421@1|root,COG5421@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2
TH1_k127_6026027_0	686340.Metal_0111	2.143e-120	398.0	COG2214@1|root,COG2214@2|Bacteria,1RDYT@1224|Proteobacteria,1T30D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	heat shock protein DnaJ	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_6026027_1	697282.Mettu_2688	1.694e-109	364.0	COG1466@1|root,COG1466@2|Bacteria,1MWYT@1224|Proteobacteria,1RQRE@1236|Gammaproteobacteria,1XE3S@135618|Methylococcales	135618|Methylococcales	L	DNA polymerase III, delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delt_C,DNA_pol3_delta
TH1_k127_6026027_3	697282.Mettu_2687	1.761e-30	127.0	COG2980@1|root,COG2980@2|Bacteria,1NGPX@1224|Proteobacteria,1SGKQ@1236|Gammaproteobacteria,1XFJ8@135618|Methylococcales	135618|Methylococcales	M	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane	lptE	-	-	ko:K03643	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptE
TH1_k127_6026027_2	686340.Metal_2398	4.902e-59	207.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,1XDZ5@135618|Methylococcales	135618|Methylococcales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
TH1_k127_6087631_2	686340.Metal_3555	3.855e-18	87.0	COG3671@1|root,COG3671@2|Bacteria,1MZMW@1224|Proteobacteria,1THRY@1236|Gammaproteobacteria,1XFM4@135618|Methylococcales	135618|Methylococcales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_6087631_4	1304877.KI519399_gene5977	8.257e-08	58.0	COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,2U5B1@28211|Alphaproteobacteria,3JUVJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Bacterial extracellular solute-binding protein	modA	GO:0003674,GO:0005488,GO:0030973,GO:0043167,GO:0043168	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
TH1_k127_6087631_0	1163617.SCD_n00041	1.488e-61	221.0	COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,2VIBH@28216|Betaproteobacteria	28216|Betaproteobacteria	U	UPF0056 inner membrane protein	marC	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
TH1_k127_6087631_1	857087.Metme_0661	2.45e-54	193.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,1S3PD@1236|Gammaproteobacteria,1XFB7@135618|Methylococcales	135618|Methylococcales	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
TH1_k127_6087631_3	697282.Mettu_0300	2.29e-12	68.0	COG3151@1|root,COG3151@2|Bacteria,1QJNF@1224|Proteobacteria,1THP7@1236|Gammaproteobacteria,1XF5H@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF1249)	-	-	-	ko:K09920	-	-	-	-	ko00000	-	-	-	DUF1249
TH1_k127_6094407_1	686340.Metal_3634	7.047e-111	367.0	COG2067@1|root,COG2067@2|Bacteria,1NQ4A@1224|Proteobacteria,1RYKE@1236|Gammaproteobacteria,1XEJE@135618|Methylococcales	135618|Methylococcales	I	Putative beta-barrel porin-2, OmpL-like. bbp2	-	-	-	-	-	-	-	-	-	-	-	-	BBP2
TH1_k127_6094407_3	686340.Metal_3634	8.019e-07	51.0	COG2067@1|root,COG2067@2|Bacteria,1NQ4A@1224|Proteobacteria,1RYKE@1236|Gammaproteobacteria,1XEJE@135618|Methylococcales	135618|Methylococcales	I	Putative beta-barrel porin-2, OmpL-like. bbp2	-	-	-	-	-	-	-	-	-	-	-	-	BBP2
TH1_k127_6094407_0	697282.Mettu_1182	3.327e-148	478.0	COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria,1XDQ5@135618|Methylococcales	135618|Methylococcales	T	Signal transduction histidine kinase	ntrB	-	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_4
TH1_k127_6094407_2	697282.Mettu_1183	7.585e-36	138.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XDX4@135618|Methylococcales	135618|Methylococcales	T	Nitrogen regulation	-	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH1_k127_6104036_7	697282.Mettu_4056	1.726e-110	360.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,1RQ7G@1236|Gammaproteobacteria,1XEMX@135618|Methylococcales	135618|Methylococcales	J	Glutamyl glutaminyl-tRNA synthetase, class Ic, anti-codon binding domain	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
TH1_k127_6104036_2	697282.Mettu_4223	8.368e-216	677.0	COG1726@1|root,COG1726@2|Bacteria,1MU36@1224|Proteobacteria,1RPU1@1236|Gammaproteobacteria,1XDP1@135618|Methylococcales	135618|Methylococcales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrA	-	1.6.5.8	ko:K00346	-	-	-	-	ko00000,ko01000	-	-	-	NQRA,NQRA_SLBB
TH1_k127_6104036_1	857087.Metme_2629	7.457e-224	697.0	COG1805@1|root,COG1805@2|Bacteria,1QTUU@1224|Proteobacteria,1RMGH@1236|Gammaproteobacteria,1XE40@135618|Methylococcales	135618|Methylococcales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrB	-	1.6.5.8	ko:K00347	-	-	-	-	ko00000,ko01000	-	-	-	NQR2_RnfD_RnfE
TH1_k127_6104036_4	857087.Metme_2628	5.785e-138	445.0	COG2869@1|root,COG2869@2|Bacteria,1MVDI@1224|Proteobacteria,1RR85@1236|Gammaproteobacteria,1XDSZ@135618|Methylococcales	135618|Methylococcales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrC	-	1.6.5.8	ko:K00348	-	-	-	-	ko00000,ko01000	-	-	-	FMN_bind
TH1_k127_6104036_5	857087.Metme_2627	3.335e-123	396.0	COG1347@1|root,COG1347@2|Bacteria,1MUZR@1224|Proteobacteria,1RNFE@1236|Gammaproteobacteria,1XE07@135618|Methylococcales	135618|Methylococcales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrD	-	1.6.5.8	ko:K00349	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
TH1_k127_6104036_6	857087.Metme_2626	3.273e-113	367.0	COG2209@1|root,COG2209@2|Bacteria,1R33S@1224|Proteobacteria,1RMWV@1236|Gammaproteobacteria,1XE4G@135618|Methylococcales	135618|Methylococcales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrE	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0055114	1.6.5.8	ko:K00350	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
TH1_k127_6104036_0	697282.Mettu_4218	2.732e-231	720.0	COG2871@1|root,COG2871@2|Bacteria,1QTUV@1224|Proteobacteria,1RPG5@1236|Gammaproteobacteria,1XECA@135618|Methylococcales	135618|Methylococcales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway	nqrF	-	1.6.5.8	ko:K00351	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
TH1_k127_6104036_9	1116472.MGMO_21c00170	1.054e-15	81.0	COG2991@1|root,COG2991@2|Bacteria,1NI0R@1224|Proteobacteria,1SGJF@1236|Gammaproteobacteria,1XFQH@135618|Methylococcales	135618|Methylococcales	S	(Na+)-NQR maturation NqrM	-	-	-	ko:K05952	-	-	-	-	ko00000	-	-	-	NqrM
TH1_k127_6104036_8	857087.Metme_2783	5.676e-49	179.0	COG0517@1|root,COG0517@2|Bacteria,1QTZR@1224|Proteobacteria,1S7SY@1236|Gammaproteobacteria,1XFFM@135618|Methylococcales	135618|Methylococcales	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TH1_k127_6104036_3	697282.Mettu_4215	5.903e-184	586.0	COG2925@1|root,COG2925@2|Bacteria,1MV0U@1224|Proteobacteria,1RM85@1236|Gammaproteobacteria,1XEUD@135618|Methylococcales	135618|Methylococcales	L	Exonuclease C-terminal	sbcB	-	3.1.11.1	ko:K01141	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_X-T_C,RNase_T
TH1_k127_6104114_0	243159.AFE_1741	9.944e-274	852.0	COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,1RQMR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KQ	transcriptional regulator	acoR	-	-	ko:K21405	-	-	-	-	ko00000,ko03000	-	-	-	GAF,HTH_8,Sigma54_activat
TH1_k127_6104114_1	1116472.MGMO_85c00380	1.143e-80	273.0	COG0116@1|root,COG1092@1|root,COG0116@2|Bacteria,COG1092@2|Bacteria,1MUQM@1224|Proteobacteria,1RNMH@1236|Gammaproteobacteria,1XEC9@135618|Methylococcales	135618|Methylococcales	J	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA	rlmL	-	2.1.1.173,2.1.1.264	ko:K12297	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,THUMP,UPF0020
TH1_k127_6119122_2	697282.Mettu_3920	7.101e-114	375.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria,1XDN9@135618|Methylococcales	135618|Methylococcales	I	Domain of unknown function (DUF1974)	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N,DUF1974
TH1_k127_6119122_0	857087.Metme_2950	2.933e-216	680.0	COG2170@1|root,COG2170@2|Bacteria,1MXET@1224|Proteobacteria,1RPKZ@1236|Gammaproteobacteria,1XE91@135618|Methylococcales	135618|Methylococcales	S	glutamate--cysteine ligase	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_6119122_1	857087.Metme_1544	9.854e-153	489.0	COG2988@1|root,COG2988@2|Bacteria	2|Bacteria	E	succinylglutamate desuccinylase activity	astE	-	3.5.1.96	ko:K05526	ko00330,ko01100,map00330,map01100	-	R00411	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	AstE_AspA
TH1_k127_6119122_3	697282.Mettu_0693	2.483e-74	254.0	COG2983@1|root,COG2983@2|Bacteria,1RHMX@1224|Proteobacteria,1S5XU@1236|Gammaproteobacteria,1XFDZ@135618|Methylococcales	135618|Methylococcales	S	Belongs to the UPF0260 family	-	-	-	ko:K09160	-	-	-	-	ko00000	-	-	-	CxxCxxCC
TH1_k127_6127543_16	1123252.ATZF01000003_gene3326	1.74e-35	145.0	COG3177@1|root,COG3177@2|Bacteria,1TZWX@1239|Firmicutes,4HFD7@91061|Bacilli	91061|Bacilli	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic
TH1_k127_6127543_2	697282.Mettu_2073	2.635e-212	666.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,1XENU@135618|Methylococcales	135618|Methylococcales	H	PFAM Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TH1_k127_6127543_14	1116472.MGMO_71c00020	1.229e-49	185.0	COG3108@1|root,COG3108@2|Bacteria,1MWW2@1224|Proteobacteria,1RS5K@1236|Gammaproteobacteria,1XF6A@135618|Methylococcales	135618|Methylococcales	S	Bacterial protein of unknown function (DUF882)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_2
TH1_k127_6127543_6	1116472.MGMO_8c00320	2.578e-116	381.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1RM8G@1236|Gammaproteobacteria,1XE7A@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
TH1_k127_6127543_7	1116472.MGMO_94c00480	1.457e-110	362.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1XEKV@135618|Methylococcales	135618|Methylococcales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
TH1_k127_6127543_17	686340.Metal_1325	1.006e-26	112.0	COG1826@1|root,COG1826@2|Bacteria,1N73F@1224|Proteobacteria,1SD9K@1236|Gammaproteobacteria,1XFRA@135618|Methylococcales	135618|Methylococcales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation	tatB	-	-	ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
TH1_k127_6127543_19	697282.Mettu_1669	2.877e-12	68.0	COG1826@1|root,COG1826@2|Bacteria,1N6S4@1224|Proteobacteria,1SCC7@1236|Gammaproteobacteria,1XFSS@135618|Methylococcales	135618|Methylococcales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	GO:0002790,GO:0003674,GO:0005215,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0034613,GO:0042886,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
TH1_k127_6127543_15	697282.Mettu_1668	6.53e-46	167.0	COG0140@1|root,COG0140@2|Bacteria,1MZEE@1224|Proteobacteria,1S8R4@1236|Gammaproteobacteria,1XF9W@135618|Methylococcales	135618|Methylococcales	E	PFAM Phosphoribosyl-ATP pyrophosphohydrolase	hisE	GO:0000105,GO:0003674,GO:0003824,GO:0004636,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.6.1.31	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-PH
TH1_k127_6127543_12	686340.Metal_1328	8.037e-63	221.0	COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,1RMV4@1236|Gammaproteobacteria,1XF4K@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	GO:0000105,GO:0003674,GO:0003824,GO:0004635,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.5.4.19	ko:K01496	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04037	RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH
TH1_k127_6127543_4	686340.Metal_1329	3.373e-144	460.0	COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,1RPJQ@1236|Gammaproteobacteria,1XE1I@135618|Methylococcales	135618|Methylococcales	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TH1_k127_6127543_5	686340.Metal_1330	4.087e-129	415.0	COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,1RN3M@1236|Gammaproteobacteria,1XETV@135618|Methylococcales	135618|Methylococcales	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TH1_k127_6127543_9	697282.Mettu_1664	3.866e-95	316.0	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,1RRP3@1236|Gammaproteobacteria,1XDZU@135618|Methylococcales	135618|Methylococcales	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	GO:0000105,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
TH1_k127_6127543_8	686340.Metal_1332	4.555e-101	332.0	COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,1RPA9@1236|Gammaproteobacteria,1XDKI@135618|Methylococcales	135618|Methylococcales	E	Imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
TH1_k127_6127543_13	1266925.JHVX01000001_gene2441	3.237e-54	194.0	COG0517@1|root,COG0517@2|Bacteria,1QTXQ@1224|Proteobacteria,2VWDB@28216|Betaproteobacteria,3734T@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TH1_k127_6127543_0	261292.Nit79A3_3272	0.0	1802.0	COG2202@1|root,COG3447@1|root,COG5001@1|root,COG2202@2|Bacteria,COG3447@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VJMN@28216|Betaproteobacteria,373T6@32003|Nitrosomonadales	28216|Betaproteobacteria	T	Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S)	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,EAL,GGDEF,HAMP,MASE1,PAS,PAS_3,PAS_4,PAS_8,PAS_9
TH1_k127_6127543_1	857087.Metme_0445	0.0	1076.0	COG1033@1|root,COG1033@2|Bacteria,1QW3H@1224|Proteobacteria,1RZA3@1236|Gammaproteobacteria,1XDIY@135618|Methylococcales	135618|Methylococcales	S	TIGRFAM Hopanoid biosynthesis associated RND transporter like protein HpnN	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
TH1_k127_6127543_10	697282.Mettu_2182	6.118e-78	267.0	COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,1S5WA@1236|Gammaproteobacteria,1XEWA@135618|Methylococcales	135618|Methylococcales	O	Thiol disulfide interchange protein	dsbA	-	-	ko:K03673	ko01503,map01503	M00728	-	-	ko00000,ko00001,ko00002,ko03110	-	-	-	DSBA
TH1_k127_6127543_3	1198232.CYCME_2487	3.794e-174	554.0	COG0755@1|root,COG0755@2|Bacteria,1RG6M@1224|Proteobacteria,1RX07@1236|Gammaproteobacteria,45ZPJ@72273|Thiotrichales	72273|Thiotrichales	O	PFAM Cytochrome c assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
TH1_k127_6127543_11	582744.Msip34_0982	2.454e-73	252.0	COG0778@1|root,COG0778@2|Bacteria,1RA6E@1224|Proteobacteria,2VSIM@28216|Betaproteobacteria,2KKHC@206350|Nitrosomonadales	206350|Nitrosomonadales	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TH1_k127_6127543_18	1283300.ATXB01000001_gene1752	5.507e-21	97.0	2EGD6@1|root,33A4Z@2|Bacteria,1N733@1224|Proteobacteria,1SF0T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
TH1_k127_6127543_20	314256.OG2516_13881	7.717e-08	57.0	COG1943@1|root,COG1943@2|Bacteria,1RCWW@1224|Proteobacteria,2U5BB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG1943 Transposase and inactivated derivatives	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
TH1_k127_6146992_0	697282.Mettu_3395	2.023e-198	631.0	COG0778@1|root,COG0778@2|Bacteria,1Q0G9@1224|Proteobacteria,1RS1G@1236|Gammaproteobacteria,1XEMQ@135618|Methylococcales	135618|Methylococcales	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TH1_k127_6146992_1	42565.FP66_09385	6.978e-06	48.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria,1XHPQ@135619|Oceanospirillales	135619|Oceanospirillales	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
TH1_k127_6158009_0	697282.Mettu_4049	7.633e-74	263.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,1RQR7@1236|Gammaproteobacteria,1XED4@135618|Methylococcales	135618|Methylococcales	S	Putative peptidoglycan binding domain	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
TH1_k127_6158009_1	1116472.MGMO_43c00270	1.698e-44	166.0	COG1051@1|root,COG1051@2|Bacteria,1QIBH@1224|Proteobacteria,1TG5S@1236|Gammaproteobacteria,1XFR5@135618|Methylococcales	135618|Methylococcales	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TH1_k127_6158009_2	697282.Mettu_0170	5.353e-41	158.0	COG2863@1|root,COG2863@2|Bacteria,1N7W9@1224|Proteobacteria,1SD0V@1236|Gammaproteobacteria,1XFCG@135618|Methylococcales	135618|Methylococcales	C	PFAM Cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
TH1_k127_6169444_1	857087.Metme_3342	4.174e-289	892.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1XE7K@135618|Methylococcales	135618|Methylococcales	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
TH1_k127_6169444_3	1116472.MGMO_175c00110	2.105e-47	174.0	COG3193@1|root,COG3193@2|Bacteria,1N08N@1224|Proteobacteria,1S7QD@1236|Gammaproteobacteria,1XF9C@135618|Methylococcales	135618|Methylococcales	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
TH1_k127_6169444_0	686340.Metal_3487	4.027e-300	924.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,1RPZX@1236|Gammaproteobacteria,1XES8@135618|Methylococcales	135618|Methylococcales	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
TH1_k127_6169444_5	857087.Metme_0406	1.144e-08	58.0	COG3668@1|root,COG3668@2|Bacteria,1N73M@1224|Proteobacteria,1T0H5@1236|Gammaproteobacteria,1XFY5@135618|Methylococcales	135618|Methylococcales	S	PFAM Plasmid stabilisation system	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
TH1_k127_6169444_4	743299.Acife_0209	2.137e-38	149.0	2D3E2@1|root,32TET@2|Bacteria,1N2S5@1224|Proteobacteria,1SBU9@1236|Gammaproteobacteria,2NDTT@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
TH1_k127_6169444_2	76114.ebA5909	7.723e-61	212.0	COG1569@1|root,COG1569@2|Bacteria,1MYFF@1224|Proteobacteria	1224|Proteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
TH1_k127_6189878_2	1116472.MGMO_55c00020	2.07e-214	668.0	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,1RME6@1236|Gammaproteobacteria,1XDVW@135618|Methylococcales	135618|Methylococcales	F	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
TH1_k127_6189878_0	857087.Metme_2692	0.0	1373.0	COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,1RQ34@1236|Gammaproteobacteria,1XDR7@135618|Methylococcales	135618|Methylococcales	KL	DNA RNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N,SWIM
TH1_k127_6189878_1	686340.Metal_1974	3.966e-238	739.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,1RMHQ@1236|Gammaproteobacteria,1XECM@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
TH1_k127_6189878_3	857087.Metme_2716	1.56e-67	235.0	COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,1RPKA@1236|Gammaproteobacteria,1XECW@135618|Methylococcales	135618|Methylococcales	G	pfam mofrl	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
TH1_k127_6216597_2	697282.Mettu_1950	2.679e-61	220.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,1XDR6@135618|Methylococcales	135618|Methylococcales	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
TH1_k127_6216597_3	686340.Metal_0002	1.1e-39	150.0	COG0594@1|root,COG0594@2|Bacteria,1MZQE@1224|Proteobacteria,1S90M@1236|Gammaproteobacteria,1XFKR@135618|Methylococcales	135618|Methylococcales	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
TH1_k127_6216597_4	686340.Metal_0003	6.933e-16	77.0	COG0230@1|root,COG0230@2|Bacteria,1NGGS@1224|Proteobacteria,1SGDJ@1236|Gammaproteobacteria,1XFUB@135618|Methylococcales	135618|Methylococcales	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
TH1_k127_6216597_0	686340.Metal_0004	2.103e-226	707.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1XDZC@135618|Methylococcales	135618|Methylococcales	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
TH1_k127_6216597_1	697282.Mettu_0043	2.419e-63	220.0	COG0684@1|root,COG0684@2|Bacteria,1RH18@1224|Proteobacteria,1RS9U@1236|Gammaproteobacteria,1XFEJ@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions	-	-	-	ko:K02553	-	-	-	-	ko00000,ko03019	-	-	-	RraA-like
TH1_k127_6233002_3	443254.Marpi_0094	2.801e-09	62.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GCCM@200918|Thermotogae	200918|Thermotogae	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
TH1_k127_6233002_0	857087.Metme_1770	1.12e-100	331.0	COG1943@1|root,COG1943@2|Bacteria,1RBPH@1224|Proteobacteria,1THP6@1236|Gammaproteobacteria,1XF5F@135618|Methylococcales	135618|Methylococcales	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_6233002_2	1349767.GJA_4985	4.321e-12	70.0	COG4783@1|root,COG4783@2|Bacteria	2|Bacteria	L	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
TH1_k127_6233002_1	1122599.AUGR01000005_gene1814	3.66e-40	156.0	COG2979@1|root,COG2979@2|Bacteria,1R95E@1224|Proteobacteria,1S2WZ@1236|Gammaproteobacteria,1XKDF@135619|Oceanospirillales	135619|Oceanospirillales	S	Protein of unknown function (DUF533)	-	-	-	-	-	-	-	-	-	-	-	-	DUF533
TH1_k127_6242885_0	697282.Mettu_2908	0.0	1105.0	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1XEMN@135618|Methylococcales	135618|Methylococcales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
TH1_k127_6242885_1	697282.Mettu_3242	2.057e-06	49.0	2DS8R@1|root,33F1A@2|Bacteria,1MZBA@1224|Proteobacteria,1SBM3@1236|Gammaproteobacteria,1XFBX@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF2380)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3280
TH1_k127_6244722_0	1116472.MGMO_10c00050	0.0	1628.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1XDSC@135618|Methylococcales	135618|Methylococcales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
TH1_k127_6244722_2	1132855.KB913035_gene1494	1.352e-132	435.0	COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,2VJXV@28216|Betaproteobacteria,2KNV2@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K07798	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1	-	-	HlyD_D23
TH1_k127_6244722_1	1116472.MGMO_10c00030	3.447e-186	592.0	COG1538@1|root,COG1538@2|Bacteria,1PCPQ@1224|Proteobacteria,1RRRP@1236|Gammaproteobacteria,1XDZV@135618|Methylococcales	135618|Methylococcales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TH1_k127_6244722_4	697282.Mettu_2019	4.202e-100	336.0	COG4395@1|root,COG4395@2|Bacteria,1NSUG@1224|Proteobacteria,1SAIV@1236|Gammaproteobacteria,1XF44@135618|Methylococcales	135618|Methylococcales	S	PFAM Mitochondrial inner membrane translocase complex, subunit Tim44-related	-	-	-	-	-	-	-	-	-	-	-	-	Tim44
TH1_k127_6244722_3	857087.Metme_0191	2.957e-116	388.0	COG1538@1|root,COG1538@2|Bacteria,1RDXS@1224|Proteobacteria,1SZYV@1236|Gammaproteobacteria,1XEDE@135618|Methylococcales	135618|Methylococcales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TH1_k127_6244722_5	697282.Mettu_2023	6.66e-10	63.0	COG0845@1|root,COG0845@2|Bacteria,1QN99@1224|Proteobacteria,1S0F7@1236|Gammaproteobacteria,1XEEX@135618|Methylococcales	135618|Methylococcales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
TH1_k127_6263322_1	857087.Metme_2837	9.052e-174	549.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,1THGR@1236|Gammaproteobacteria,1XDV9@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TH1_k127_6263322_0	697282.Mettu_1040	3.83e-223	696.0	COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,1RPEU@1236|Gammaproteobacteria,1XEDH@135618|Methylococcales	135618|Methylococcales	E	homoserine dehydrogenase	hom	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
TH1_k127_6276334_0	686340.Metal_2051	3.37e-183	583.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1XDJB@135618|Methylococcales	135618|Methylococcales	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
TH1_k127_6276334_2	857087.Metme_1371	3.991e-133	434.0	COG2957@1|root,COG2957@2|Bacteria,1MX65@1224|Proteobacteria,1RMF1@1236|Gammaproteobacteria,1XDYB@135618|Methylococcales	135618|Methylococcales	E	Belongs to the agmatine deiminase family	-	-	-	-	-	-	-	-	-	-	-	-	PAD_porph
TH1_k127_6276334_1	697282.Mettu_0157	2.073e-154	492.0	COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,1RP7S@1236|Gammaproteobacteria,1XE3W@135618|Methylococcales	135618|Methylococcales	S	Carbon-nitrogen hydrolase	-	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
TH1_k127_6276928_0	697282.Mettu_2155	1.696e-223	694.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,1XEAV@135618|Methylococcales	135618|Methylococcales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
TH1_k127_6276928_2	857087.Metme_4504	1.109e-61	214.0	COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,1S25H@1236|Gammaproteobacteria,1XF6N@135618|Methylococcales	135618|Methylococcales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
TH1_k127_6276928_1	686340.Metal_3767	8.997e-158	507.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,1RNKE@1236|Gammaproteobacteria,1XEPU@135618|Methylococcales	135618|Methylococcales	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
TH1_k127_6304815_7	1415779.JOMH01000001_gene1662	0.0002564	48.0	COG1943@1|root,COG1943@2|Bacteria,1RCWW@1224|Proteobacteria,1S3ZJ@1236|Gammaproteobacteria,1X6YP@135614|Xanthomonadales	135614|Xanthomonadales	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
TH1_k127_6304815_2	1448139.AI20_18385	1.071e-32	128.0	COG1943@1|root,COG1943@2|Bacteria,1RCWW@1224|Proteobacteria,1S3ZJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase and inactivated derivatives	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
TH1_k127_6304815_4	1122165.AUHS01000003_gene1982	1.161e-11	66.0	COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,1S3Y7@1236|Gammaproteobacteria,1JEBZ@118969|Legionellales	118969|Legionellales	J	Required for maturation of 30S ribosomal subunits	rimP	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
TH1_k127_6304815_1	1123261.AXDW01000001_gene1108	5.932e-49	179.0	COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,1S3Y7@1236|Gammaproteobacteria,1X5YX@135614|Xanthomonadales	135614|Xanthomonadales	S	Required for maturation of 30S ribosomal subunits	rimP	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
TH1_k127_6304815_0	697282.Mettu_4213	1.281e-229	720.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1XE32@135618|Methylococcales	135618|Methylococcales	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
TH1_k127_6304815_3	857087.Metme_1291	1.162e-13	72.0	COG0532@1|root,COG3064@1|root,COG0532@2|Bacteria,COG3064@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1XDQX@135618|Methylococcales	135618|Methylococcales	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N,IF2_assoc
TH1_k127_6315914_2	857087.Metme_0603	0.0009153	44.0	COG4244@1|root,COG4244@2|Bacteria,1NPG4@1224|Proteobacteria,1SZU6@1236|Gammaproteobacteria,1XH0G@135618|Methylococcales	135618|Methylococcales	S	Predicted membrane protein (DUF2231)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231
TH1_k127_6315914_0	697282.Mettu_0847	1.912e-161	512.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1XE1W@135618|Methylococcales	135618|Methylococcales	E	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	2.5.1.47	ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TH1_k127_6315914_1	697282.Mettu_0848	8.401e-67	246.0	COG2911@1|root,COG2911@2|Bacteria,1MW9V@1224|Proteobacteria,1S3FX@1236|Gammaproteobacteria,1XDS4@135618|Methylococcales	135618|Methylococcales	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_6322526_2	686340.Metal_2868	2.739e-186	594.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,1RN6C@1236|Gammaproteobacteria,1XEBW@135618|Methylococcales	135618|Methylococcales	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
TH1_k127_6322526_8	857087.Metme_3405	3.106e-24	103.0	COG0666@1|root,COG0666@2|Bacteria,1Q6E0@1224|Proteobacteria,1TGU6@1236|Gammaproteobacteria,1XGPN@135618|Methylococcales	135618|Methylococcales	S	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_6322526_11	686340.Metal_2870	2.331e-19	89.0	2B7RT@1|root,320Y1@2|Bacteria,1QK8A@1224|Proteobacteria,1TIBR@1236|Gammaproteobacteria,1XGXE@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_6322526_14	596154.Alide2_1786	1.434e-05	48.0	COG1061@1|root,COG1061@2|Bacteria,1MX92@1224|Proteobacteria,2VM99@28216|Betaproteobacteria,4ADAJ@80864|Comamonadaceae	28216|Betaproteobacteria	KL	PFAM Restriction endonuclease, type I, R subunit Type III, Res subunit	-	-	3.1.21.5	ko:K01156	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	ResIII
TH1_k127_6322526_10	388051.AUFE01000011_gene5315	4.361e-21	93.0	COG1061@1|root,COG1061@2|Bacteria,1MX92@1224|Proteobacteria,2VM99@28216|Betaproteobacteria,1K05X@119060|Burkholderiaceae	28216|Betaproteobacteria	KL	Type III restriction enzyme, res subunit	-	-	3.1.21.5	ko:K01156	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	ResIII
TH1_k127_6322526_3	857087.Metme_0932	1.739e-183	602.0	COG0457@1|root,COG0457@2|Bacteria,1R87H@1224|Proteobacteria,1RYZI@1236|Gammaproteobacteria,1XGJ4@135618|Methylococcales	135618|Methylococcales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_6322526_9	857087.Metme_0933	3.43e-24	106.0	COG0484@1|root,COG0484@2|Bacteria,1NHTD@1224|Proteobacteria,1SCW2@1236|Gammaproteobacteria,1XGSZ@135618|Methylococcales	135618|Methylococcales	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
TH1_k127_6322526_7	857087.Metme_0934	5.104e-59	211.0	COG0576@1|root,COG0576@2|Bacteria,1MZ1K@1224|Proteobacteria,1S8FS@1236|Gammaproteobacteria,1XGXK@135618|Methylococcales	135618|Methylococcales	O	GrpE	-	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
TH1_k127_6322526_1	857087.Metme_0935	1.254e-273	851.0	COG0443@1|root,COG0443@2|Bacteria,1Q5TZ@1224|Proteobacteria,1RZCY@1236|Gammaproteobacteria,1XG6Y@135618|Methylococcales	135618|Methylococcales	O	MreB/Mbl protein	-	-	-	-	-	-	-	-	-	-	-	-	HSP70
TH1_k127_6322526_13	697282.Mettu_4290	1.438e-06	50.0	COG4276@1|root,COG4276@2|Bacteria,1N2Z3@1224|Proteobacteria,1SRI2@1236|Gammaproteobacteria,1XGFS@135618|Methylococcales	135618|Methylococcales	S	Pfam Polyketide cyclase dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_6322526_4	697282.Mettu_3594	8.301e-137	441.0	COG1090@1|root,COG1090@2|Bacteria,1MUB4@1224|Proteobacteria,1RN6A@1236|Gammaproteobacteria,1XE2V@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF1731)	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
TH1_k127_6322526_5	243233.MCA2709	7.074e-97	328.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,1RNN1@1236|Gammaproteobacteria,1XF1S@135618|Methylococcales	135618|Methylococcales	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TH1_k127_6322526_0	765914.ThisiDRAFT_2476	0.0	1296.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1WY9Q@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC
TH1_k127_6322526_6	686340.Metal_0107	1.307e-88	299.0	COG1629@1|root,COG4771@2|Bacteria,1QTS8@1224|Proteobacteria,1T1FF@1236|Gammaproteobacteria,1XDZE@135618|Methylococcales	135618|Methylococcales	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
TH1_k127_6325285_4	686340.Metal_2841	4.123e-47	172.0	COG3735@1|root,COG3735@2|Bacteria,1MVCW@1224|Proteobacteria,1RRI8@1236|Gammaproteobacteria,1XGJP@135618|Methylococcales	135618|Methylococcales	S	TraB family	-	-	-	-	-	-	-	-	-	-	-	-	TraB
TH1_k127_6325285_1	686340.Metal_2842	3.807e-99	327.0	COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,1RMP3@1236|Gammaproteobacteria,1XEJW@135618|Methylococcales	135618|Methylococcales	O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress	hslO	-	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
TH1_k127_6325285_5	686340.Metal_1582	5.853e-40	149.0	COG2963@1|root,COG2963@2|Bacteria,1QWAU@1224|Proteobacteria,1TI7V@1236|Gammaproteobacteria,1XGQQ@135618|Methylococcales	135618|Methylococcales	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_6325285_3	686340.Metal_0954	2.994e-59	208.0	COG3436@1|root,COG3436@2|Bacteria,1N0VT@1224|Proteobacteria,1S76D@1236|Gammaproteobacteria,1XFVJ@135618|Methylococcales	135618|Methylococcales	L	PFAM IS66 Orf2 like protein	-	-	-	-	-	-	-	-	-	-	-	-	TnpB_IS66
TH1_k127_6325285_0	686340.Metal_1534	7.702e-311	956.0	COG2433@1|root,COG2433@2|Bacteria,1RJ1Q@1224|Proteobacteria,1SE0M@1236|Gammaproteobacteria,1XGD4@135618|Methylococcales	1236|Gammaproteobacteria	S	PFAM Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
TH1_k127_6325285_2	1116472.MGMO_80c00010	1.834e-66	232.0	COG0657@1|root,COG0657@2|Bacteria,1N2XW@1224|Proteobacteria,1RRAQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	esterase lipase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Peptidase_S9
TH1_k127_6332677_0	857087.Metme_3746	1.552e-313	977.0	COG4773@1|root,COG4773@2|Bacteria,1QVK7@1224|Proteobacteria,1T53A@1236|Gammaproteobacteria,1XDUB@135618|Methylococcales	135618|Methylococcales	P	TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
TH1_k127_6332677_7	697282.Mettu_0508	2.68e-80	272.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,1RQ1J@1236|Gammaproteobacteria,1XF2P@135618|Methylococcales	135618|Methylococcales	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TH1_k127_6332677_2	697282.Mettu_0509	2.045e-140	459.0	COG4585@1|root,COG4585@2|Bacteria,1RHF6@1224|Proteobacteria,1S8ER@1236|Gammaproteobacteria,1XEPJ@135618|Methylococcales	135618|Methylococcales	T	Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor region	-	-	2.7.13.3	ko:K07675	ko02020,map02020	M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA_3,LapD_MoxY_N
TH1_k127_6332677_5	1283300.ATXB01000001_gene566	2.358e-88	296.0	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,1S2R0@1236|Gammaproteobacteria,1XFYM@135618|Methylococcales	135618|Methylococcales	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
TH1_k127_6332677_10	686340.Metal_3356	1.728e-66	231.0	COG1495@1|root,COG1495@2|Bacteria,1RIJE@1224|Proteobacteria,1S6WD@1236|Gammaproteobacteria,1XEYA@135618|Methylococcales	135618|Methylococcales	O	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein	dsbB	-	-	ko:K03611	-	-	-	-	ko00000,ko03110	5.A.2.1	-	-	DsbB
TH1_k127_6332677_6	697282.Mettu_1583	1.182e-80	275.0	COG1226@1|root,COG1226@2|Bacteria,1QRWR@1224|Proteobacteria,1SPPS@1236|Gammaproteobacteria,1XG34@135618|Methylococcales	135618|Methylococcales	C	PFAM Regulator of K conductance, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TrkA_N
TH1_k127_6332677_1	697282.Mettu_1584	2.011e-194	625.0	COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,1RR35@1236|Gammaproteobacteria,1XG89@135618|Methylococcales	135618|Methylococcales	P	PFAM Regulator of K conductance, N-terminal	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans,TrkA_N
TH1_k127_6332677_3	686340.Metal_1372	1.712e-109	360.0	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,1RNQK@1236|Gammaproteobacteria,1XEAB@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
TH1_k127_6332677_9	697282.Mettu_1590	1.693e-68	242.0	COG0762@1|root,COG0762@2|Bacteria,1RCZV@1224|Proteobacteria,1S6DW@1236|Gammaproteobacteria,1XF20@135618|Methylococcales	135618|Methylococcales	S	YGGT family	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
TH1_k127_6332677_8	697282.Mettu_1592	5.684e-76	267.0	COG2433@1|root,COG2433@2|Bacteria,1N0ZS@1224|Proteobacteria,1S7FF@1236|Gammaproteobacteria,1XF02@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF4124)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124
TH1_k127_6332677_4	686340.Metal_1375	1.159e-106	348.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,1RNKK@1236|Gammaproteobacteria,1XEDQ@135618|Methylococcales	135618|Methylococcales	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
TH1_k127_6335047_6	1236542.BALM01000007_gene3417	2.689e-49	182.0	COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,1S3T3@1236|Gammaproteobacteria,2Q93P@267890|Shewanellaceae	1236|Gammaproteobacteria	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant	gph	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
TH1_k127_6335047_5	697282.Mettu_3848	1.679e-130	423.0	COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,1RPAN@1236|Gammaproteobacteria,1XEE0@135618|Methylococcales	135618|Methylococcales	J	Responsible for synthesis of pseudouridine from uracil	rluC	-	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TH1_k127_6335047_1	697282.Mettu_3849	5.281e-304	947.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,1XDRJ@135618|Methylococcales	135618|Methylococcales	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
TH1_k127_6335047_4	857087.Metme_0732	2.73e-141	460.0	COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,1RPEZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2206 HD-GYP domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD,HD_5
TH1_k127_6335047_3	1116472.MGMO_85c00340	8.208e-241	754.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,1RNUS@1236|Gammaproteobacteria,1XDIP@135618|Methylococcales	135618|Methylococcales	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
TH1_k127_6335047_0	697282.Mettu_1405	0.0	1982.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1XE0B@135618|Methylococcales	135618|Methylococcales	H	Vitamin B12 dependent methionine synthase, activation	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
TH1_k127_6335047_10	1190606.AJYG01000029_gene3107	1.415e-08	57.0	2CDU3@1|root,33AS4@2|Bacteria,1NGWQ@1224|Proteobacteria,1SGBH@1236|Gammaproteobacteria,1XZDP@135623|Vibrionales	135623|Vibrionales	S	Protein of unknown function (DUF2970)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2970
TH1_k127_6335047_7	697282.Mettu_1407	3.038e-23	104.0	2BJIF@1|root,32DVE@2|Bacteria,1QJQV@1224|Proteobacteria,1THS4@1236|Gammaproteobacteria,1XFI2@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_6335047_8	243233.MCA1546	5.8e-18	89.0	2B2J7@1|root,31V4B@2|Bacteria,1QJQG@1224|Proteobacteria,1THRN@1236|Gammaproteobacteria,1XFGQ@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_6335047_2	697282.Mettu_1410	2.292e-254	799.0	COG3011@1|root,COG3011@2|Bacteria,1RFKG@1224|Proteobacteria,1T0YQ@1236|Gammaproteobacteria,1XDY7@135618|Methylococcales	135618|Methylococcales	S	Vitamin K-dependent gamma-carboxylase	-	-	-	-	-	-	-	-	-	-	-	-	DUF393,VKG_Carbox
TH1_k127_6349437_0	697282.Mettu_2833	2.614e-133	430.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RMN0@1236|Gammaproteobacteria,1XE9F@135618|Methylococcales	135618|Methylococcales	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
TH1_k127_6349437_1	986075.CathTA2_1010	6.663e-90	301.0	COG0189@1|root,COG0189@2|Bacteria,1TWCJ@1239|Firmicutes,4HCWW@91061|Bacilli	91061|Bacilli	HJ	RimK-like ATP-grasp domain	-	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK
TH1_k127_6351229_6	243233.MCA1848	3.583e-45	168.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1XE3D@135618|Methylococcales	135618|Methylococcales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
TH1_k127_6351229_3	1116472.MGMO_45c00700	1.543e-101	336.0	COG3748@1|root,COG3748@2|Bacteria,1RFIZ@1224|Proteobacteria,1S8F8@1236|Gammaproteobacteria,1XEI4@135618|Methylococcales	135618|Methylococcales	S	Urate oxidase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Urate_ox_N
TH1_k127_6351229_1	697282.Mettu_2741	0.0	1076.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1XEPA@135618|Methylococcales	135618|Methylococcales	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
TH1_k127_6351229_0	243233.MCA1761	0.0	1215.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1XDXD@135618|Methylococcales	135618|Methylococcales	P	TIGRFAM ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
TH1_k127_6351229_2	261292.Nit79A3_3068	2.935e-186	597.0	COG3488@1|root,COG3488@2|Bacteria	2|Bacteria	C	Di-haem oxidoreductase, putative peroxidase	-	-	3.2.1.45	ko:K01201	ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142	-	R01498	RC00059,RC00451	ko00000,ko00001,ko01000	-	GH30	-	DHOR
TH1_k127_6351229_5	316067.Geob_3308	1.48e-47	195.0	COG2373@1|root,COG3291@1|root,COG5276@1|root,COG2373@2|Bacteria,COG3291@2|Bacteria,COG5276@2|Bacteria,1R7A1@1224|Proteobacteria,42Y4U@68525|delta/epsilon subdivisions,2WU72@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	IgGFc binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_1,IgGFc_binding
TH1_k127_6351229_4	715451.ambt_03890	1.53e-51	208.0	COG5276@1|root,COG5276@2|Bacteria,1R46A@1224|Proteobacteria,1RY7V@1236|Gammaproteobacteria,46D9Z@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,LVIVD
TH1_k127_6356253_1	1116472.MGMO_8c00340	1.931e-71	248.0	COG0500@1|root,COG2226@2|Bacteria,1RDI3@1224|Proteobacteria,1S423@1236|Gammaproteobacteria,1XFA5@135618|Methylococcales	135618|Methylococcales	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25
TH1_k127_6356253_0	697282.Mettu_0636	2.831e-110	364.0	COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,1RMYP@1236|Gammaproteobacteria,1XEUS@135618|Methylococcales	135618|Methylococcales	E	Pyridoxal-phosphate dependent enzyme	-	-	3.5.99.7	ko:K01505	ko00270,map00270	-	R00997	RC00419	ko00000,ko00001,ko01000	-	-	-	PALP
TH1_k127_6356253_2	686340.Metal_3078	3.388e-69	245.0	COG1073@1|root,COG1073@2|Bacteria,1R8S6@1224|Proteobacteria,1S4WS@1236|Gammaproteobacteria,1XGDM@135618|Methylococcales	135618|Methylococcales	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_6356253_3	1116472.MGMO_55c00360	6.343e-15	76.0	COG2091@1|root,COG2091@2|Bacteria,1MZHC@1224|Proteobacteria,1SCGA@1236|Gammaproteobacteria,1XFGV@135618|Methylococcales	135618|Methylococcales	H	Belongs to the P-Pant transferase superfamily	-	-	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
TH1_k127_6379525_1	697282.Mettu_1208	2.188e-61	218.0	COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,1RPJP@1236|Gammaproteobacteria,1XEXS@135618|Methylococcales	135618|Methylococcales	L	Belongs to the DnaA family. HdA subfamily	-	-	-	ko:K10763	-	-	-	-	ko00000,ko03032	-	-	-	Bac_DnaA
TH1_k127_6379525_3	1116472.MGMO_66c00520	3.211e-24	106.0	COG3308@1|root,COG3308@2|Bacteria,1QJQY@1224|Proteobacteria,1THS8@1236|Gammaproteobacteria,1XFIH@135618|Methylococcales	135618|Methylococcales	S	Predicted membrane protein (DUF2069)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2069
TH1_k127_6379525_0	686340.Metal_1715	6.163e-84	283.0	COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,1S23B@1236|Gammaproteobacteria,1XEUT@135618|Methylococcales	135618|Methylococcales	S	Belongs to the WrbA family	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red
TH1_k127_6379525_2	697282.Mettu_1205	2.38e-48	175.0	COG1393@1|root,COG1393@2|Bacteria,1MZ4Z@1224|Proteobacteria,1S8XH@1236|Gammaproteobacteria,1XFED@135618|Methylococcales	135618|Methylococcales	C	arsenate reductase	-	-	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC
TH1_k127_6385230_8	1485545.JQLW01000010_gene1512	2.68e-18	90.0	COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria	1224|Proteobacteria	P	COG0659 Sulfate permease and related transporters (MFS superfamily	bicA	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp,cNMP_binding
TH1_k127_6385230_1	686340.Metal_2066	1.713e-256	801.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1XER8@135618|Methylococcales	135618|Methylococcales	JKL	DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation	deaD	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
TH1_k127_6385230_0	857087.Metme_4105	0.0	1320.0	COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,1RN48@1236|Gammaproteobacteria,1XDTT@135618|Methylococcales	135618|Methylococcales	C	Oxidizes proline to glutamate for use as a carbon and nitrogen source	-	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh,Pro_dh-DNA_bdg
TH1_k127_6385230_9	264732.Moth_0514	6.352e-11	68.0	COG4747@1|root,COG4747@2|Bacteria,1V7U2@1239|Firmicutes,24JE5@186801|Clostridia,42GI5@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM amino acid-binding ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ACT
TH1_k127_6385230_4	240016.ABIZ01000001_gene4052	2.261e-147	476.0	COG0076@1|root,COG0076@2|Bacteria	2|Bacteria	E	glutamate decarboxylase activity	hdc	-	4.1.1.22	ko:K01590	ko00340,ko01100,ko01110,map00340,map01100,map01110	-	R01167	RC00299	ko00000,ko00001,ko01000	-	-	-	Pyridoxal_deC
TH1_k127_6385230_10	1117647.M5M_05355	9.561e-08	53.0	COG1393@1|root,COG1393@2|Bacteria,1MZ6S@1224|Proteobacteria,1S8TR@1236|Gammaproteobacteria,1J6PT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Belongs to the ArsC family	yffB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC
TH1_k127_6385230_2	697282.Mettu_0479	2.715e-185	585.0	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,1RMNQ@1236|Gammaproteobacteria,1XEMH@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
TH1_k127_6385230_3	697282.Mettu_3184	5.468e-160	521.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,1XEGJ@135618|Methylococcales	135618|Methylococcales	M	membrane-bound lytic murein transglycosylase	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
TH1_k127_6385230_6	697282.Mettu_3185	7.578e-71	246.0	COG0500@1|root,COG2226@2|Bacteria,1QTWC@1224|Proteobacteria,1RS4G@1236|Gammaproteobacteria,1XEM0@135618|Methylococcales	135618|Methylococcales	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TH1_k127_6385230_7	686340.Metal_3825	1.212e-67	233.0	COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,1S3YC@1236|Gammaproteobacteria,1XF5B@135618|Methylococcales	135618|Methylococcales	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
TH1_k127_6385230_5	756272.Plabr_3346	2.875e-73	252.0	COG0733@1|root,COG0733@2|Bacteria,2J29X@203682|Planctomycetes	203682|Planctomycetes	S	Sodium:neurotransmitter symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SNF
TH1_k127_6391733_0	697282.Mettu_0695	8.822e-235	736.0	COG1132@1|root,COG1132@2|Bacteria,1N1Z8@1224|Proteobacteria,1RPVC@1236|Gammaproteobacteria,1XEI6@135618|Methylococcales	135618|Methylococcales	V	ABC transporter transmembrane region	-	-	-	ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1	-	-	ABC_membrane,ABC_tran
TH1_k127_6391733_1	697282.Mettu_0696	2.47e-30	127.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,1XEAS@135618|Methylococcales	135618|Methylococcales	M	Soluble lytic murein transglycosylase L domain	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,SLT_L
TH1_k127_6423066_4	697282.Mettu_2188	7.706e-42	157.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1XDRC@135618|Methylococcales	135618|Methylococcales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
TH1_k127_6423066_1	1116472.MGMO_133c00060	4.89e-150	486.0	COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1XEMJ@135618|Methylococcales	135618|Methylococcales	M	transferase	-	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_1,Glycos_transf_N
TH1_k127_6423066_0	857087.Metme_1549	1.219e-155	496.0	COG0451@1|root,COG0451@2|Bacteria,1MVE4@1224|Proteobacteria,1RP2S@1236|Gammaproteobacteria,1XEND@135618|Methylococcales	135618|Methylococcales	GM	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose	hldD	-	5.1.3.20	ko:K03274	ko00540,ko01100,map00540,map01100	M00064	R05176	RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase
TH1_k127_6423066_2	697282.Mettu_3649	2.324e-61	215.0	COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,1S3WS@1236|Gammaproteobacteria,1XF4M@135618|Methylococcales	135618|Methylococcales	J	Binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
TH1_k127_6423066_3	697282.Mettu_3650	1.913e-51	187.0	2BFY8@1|root,329TX@2|Bacteria,1R582@1224|Proteobacteria,1RY97@1236|Gammaproteobacteria,1XER1@135618|Methylococcales	135618|Methylococcales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2232
TH1_k127_6426648_0	686340.Metal_2703	0.0	1039.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1XE53@135618|Methylococcales	135618|Methylococcales	L	it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction	rep	-	3.6.4.12	ko:K03656	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
TH1_k127_6426648_1	243233.MCA0647	3.359e-37	149.0	COG1226@1|root,32Y28@2|Bacteria,1NEAT@1224|Proteobacteria,1S588@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
TH1_k127_6446199_1	697282.Mettu_2600	2.603e-56	205.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1XE75@135618|Methylococcales	135618|Methylococcales	D	Ftsk_gamma	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
TH1_k127_6446199_0	697282.Mettu_1061	0.0	2265.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,1RSNV@1236|Gammaproteobacteria,1XDT8@135618|Methylococcales	135618|Methylococcales	L	DEAD DEAH box	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
TH1_k127_6450894_2	697282.Mettu_2388	9.76e-105	345.0	COG4191@1|root,COG4191@2|Bacteria,1MWR3@1224|Proteobacteria,1RMH4@1236|Gammaproteobacteria,1XDPA@135618|Methylococcales	135618|Methylococcales	T	Histidine kinase	-	-	2.7.13.3	ko:K15011	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c
TH1_k127_6450894_3	697282.Mettu_2389	2.273e-90	301.0	COG4567@1|root,COG4567@2|Bacteria,1RD7J@1224|Proteobacteria,1S3PE@1236|Gammaproteobacteria,1XE1Z@135618|Methylococcales	135618|Methylococcales	T	response regulator	-	-	-	ko:K15012	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg
TH1_k127_6450894_1	857087.Metme_1840	4.675e-121	393.0	COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,1RNVU@1236|Gammaproteobacteria,1XEHR@135618|Methylococcales	135618|Methylococcales	S	MazG nucleotide pyrophosphohydrolase domain	-	-	3.6.1.9	ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323	RC00002	ko00000,ko00001,ko01000	-	-	-	MazG
TH1_k127_6450894_0	857087.Metme_1839	2.038e-170	538.0	COG0524@1|root,COG0524@2|Bacteria,1QTMS@1224|Proteobacteria,1RQQY@1236|Gammaproteobacteria,1XDKQ@135618|Methylococcales	135618|Methylococcales	G	pfkB family carbohydrate kinase	-	-	2.7.1.20	ko:K00856	ko00230,ko01100,map00230,map01100	-	R00185	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
TH1_k127_6480856_3	930169.B5T_04012	0.0001093	52.0	COG1487@1|root,COG1487@2|Bacteria,1MZB6@1224|Proteobacteria,1S4JD@1236|Gammaproteobacteria,1XKGP@135619|Oceanospirillales	135619|Oceanospirillales	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
TH1_k127_6480856_1	857087.Metme_2965	2.595e-94	311.0	COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,1S36X@1236|Gammaproteobacteria,1XECX@135618|Methylococcales	135618|Methylococcales	S	FeS assembly SUF system protein SufT	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
TH1_k127_6480856_2	1116472.MGMO_91c00100	4.741e-93	312.0	COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,1RNNV@1236|Gammaproteobacteria,1XEU9@135618|Methylococcales	135618|Methylococcales	IQ	short-chain dehydrogenase reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TH1_k127_6480856_0	697282.Mettu_2644	2.539e-113	368.0	COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,1RMV7@1236|Gammaproteobacteria,1XE52@135618|Methylococcales	135618|Methylococcales	H	O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway	ubiG	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008689,GO:0008757,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0061542,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23
TH1_k127_6484911_0	697282.Mettu_0133	6.452e-167	531.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1XE9P@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	-	2.3.1.47	ko:K00652	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03210,R10124	RC00004,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TH1_k127_6484911_1	686340.Metal_2957	2.976e-82	281.0	COG0596@1|root,COG0596@2|Bacteria,1QUBR@1224|Proteobacteria,1RSF9@1236|Gammaproteobacteria,1XF2Y@135618|Methylococcales	135618|Methylococcales	S	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters	bioH	GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.1.1.85	ko:K02170	ko00780,ko01100,map00780,map01100	M00572	R09725	RC00460,RC00461	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
TH1_k127_6484911_2	697282.Mettu_0135	4.867e-71	249.0	COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1XF4S@135618|Methylococcales	135618|Methylococcales	H	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway	bioC	GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
TH1_k127_6493548_1	857087.Metme_0613	8.179e-99	327.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XDYH@135618|Methylococcales	135618|Methylococcales	T	Diguanylate cyclase phosphodiesterase with PAS PAC	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF
TH1_k127_6493548_3	686340.Metal_3480	2.127e-74	257.0	COG3577@1|root,COG3577@2|Bacteria,1RAQK@1224|Proteobacteria,1S2GF@1236|Gammaproteobacteria,1XGKN@135618|Methylococcales	135618|Methylococcales	S	gag-polyprotein putative aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	gag-asp_proteas
TH1_k127_6493548_0	1116472.MGMO_172c00080	4.012e-145	462.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,1XE0H@135618|Methylococcales	135618|Methylococcales	L	PFAM Endonuclease Exonuclease phosphatase	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
TH1_k127_6493548_2	697282.Mettu_3337	5.65e-77	261.0	COG1573@1|root,COG1573@2|Bacteria,1QJIF@1224|Proteobacteria,1THIQ@1236|Gammaproteobacteria,1XEAT@135618|Methylococcales	135618|Methylococcales	L	uracil-DNA	-	-	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TH1_k127_6508405_3	686340.Metal_1975	3.343e-43	162.0	COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,1RPKA@1236|Gammaproteobacteria,1XECW@135618|Methylococcales	135618|Methylococcales	G	pfam mofrl	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
TH1_k127_6508405_1	697282.Mettu_1431	6.072e-126	408.0	COG0373@1|root,COG0373@2|Bacteria,1R5VH@1224|Proteobacteria,1S2KV@1236|Gammaproteobacteria,1XEEN@135618|Methylococcales	135618|Methylococcales	C	PFAM Methylene-tetrahydromethanopterin dehydrogenase, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Mpt_N
TH1_k127_6508405_0	697282.Mettu_1430	3.579e-160	509.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,1RMAX@1236|Gammaproteobacteria,1XDVH@135618|Methylococcales	135618|Methylococcales	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
TH1_k127_6508405_2	1266925.JHVX01000002_gene1096	1.217e-67	234.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,2VWSZ@28216|Betaproteobacteria,3731R@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
TH1_k127_6508405_4	697282.Mettu_4041	1.855e-23	106.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria,1XEA1@135618|Methylococcales	135618|Methylococcales	E	PFAM Bacterial NAD-glutamate dehydrogenase	-	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
TH1_k127_6528043_4	697282.Mettu_1694	4.704e-31	123.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,1RMFQ@1236|Gammaproteobacteria,1XE9T@135618|Methylococcales	135618|Methylococcales	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
TH1_k127_6528043_2	371042.NG99_07665	9.322e-40	148.0	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,1S8R2@1236|Gammaproteobacteria,3X6NU@551|Erwinia	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
TH1_k127_6528043_1	697282.Mettu_1696	1.494e-47	172.0	COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,1S5VB@1236|Gammaproteobacteria,1XFB6@135618|Methylococcales	135618|Methylococcales	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
TH1_k127_6528043_0	697282.Mettu_1697	9.447e-163	517.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,1RPR7@1236|Gammaproteobacteria,1XECC@135618|Methylococcales	135618|Methylococcales	H	Belongs to the FPP GGPP synthase family	ispB	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
TH1_k127_6528043_3	1283300.ATXB01000002_gene2557	5.882e-37	141.0	COG4974@1|root,COG4974@2|Bacteria,1QV9T@1224|Proteobacteria,1T2UQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_3,Phage_int_SAM_3,Phage_int_SAM_5,Phage_integrase
TH1_k127_6528043_5	1419583.V466_29155	3.539e-12	69.0	COG2932@1|root,COG2932@2|Bacteria,1PIRG@1224|Proteobacteria,1S499@1236|Gammaproteobacteria,1YNAW@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	K	Transcriptional regulator	prtR_1	-	-	-	-	-	-	-	-	-	-	-	HTH_3,Peptidase_S24
TH1_k127_6538290_0	857087.Metme_0613	2.8e-172	550.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XDYH@135618|Methylococcales	135618|Methylococcales	T	Diguanylate cyclase phosphodiesterase with PAS PAC	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF
TH1_k127_6550817_2	1173024.KI912149_gene6418	2.814e-38	144.0	COG4115@1|root,COG4115@2|Bacteria,1G8CY@1117|Cyanobacteria,1JMF0@1189|Stigonemataceae	1117|Cyanobacteria	S	YoeB-like toxin of bacterial type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	YoeB_toxin
TH1_k127_6550817_3	1517416.IDAT_02075	2.596e-34	133.0	COG2161@1|root,COG2161@2|Bacteria,1N07B@1224|Proteobacteria,1S90V@1236|Gammaproteobacteria,2QGYZ@267893|Idiomarinaceae	1236|Gammaproteobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
TH1_k127_6550817_1	857087.Metme_3841	4.269e-139	448.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria,1XFRX@135618|Methylococcales	135618|Methylococcales	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
TH1_k127_6550817_0	697282.Mettu_1027	4.8e-143	464.0	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,1RMFJ@1236|Gammaproteobacteria,1XEUV@135618|Methylococcales	135618|Methylococcales	H	TonB dependent receptor	-	-	-	ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14.3	-	-	Plug,TonB_dep_Rec
TH1_k127_6570691_0	697282.Mettu_0141	5.595e-318	975.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1XEW1@135618|Methylococcales	135618|Methylococcales	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
TH1_k127_6570691_2	697282.Mettu_0143	4.134e-152	484.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,1RN9D@1236|Gammaproteobacteria,1XDSW@135618|Methylococcales	135618|Methylococcales	C	Cytochrome c oxidase subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
TH1_k127_6570691_7	697282.Mettu_0144	2.056e-18	89.0	2EGIJ@1|root,33AAQ@2|Bacteria,1NH9B@1224|Proteobacteria,1SGKJ@1236|Gammaproteobacteria,1XFSX@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF2909)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2909
TH1_k127_6570691_4	697282.Mettu_0145	2.282e-78	269.0	COG3346@1|root,COG3346@2|Bacteria,1MZUH@1224|Proteobacteria,1S8S0@1236|Gammaproteobacteria,1XEXY@135618|Methylococcales	135618|Methylococcales	S	SURF1-like protein	-	-	-	ko:K14998	-	-	-	-	ko00000,ko03029	3.D.4.8	-	-	SURF1
TH1_k127_6570691_6	1116472.MGMO_15c00170	8e-57	204.0	COG1999@1|root,COG1999@2|Bacteria,1N6R6@1224|Proteobacteria,1SI8Q@1236|Gammaproteobacteria,1XF11@135618|Methylococcales	135618|Methylococcales	S	signal sequence binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_6570691_1	1283300.ATXB01000001_gene1084	6.949e-186	602.0	COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,1RNIN@1236|Gammaproteobacteria,1XE6A@135618|Methylococcales	135618|Methylococcales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	COX15-CtaA,SRP54,SRP54_N
TH1_k127_6570691_3	697282.Mettu_0148	1.117e-101	337.0	COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,1RMZA@1236|Gammaproteobacteria,1XE05@135618|Methylococcales	135618|Methylococcales	D	cell division ATP-binding protein FtsE	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
TH1_k127_6570691_5	857087.Metme_3146	9.512e-66	231.0	COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,1RYBV@1236|Gammaproteobacteria,1XE8P@135618|Methylococcales	135618|Methylococcales	D	Part of the ABC transporter FtsEX involved in cellular division	-	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	-
TH1_k127_6571111_1	857087.Metme_3259	1.624e-121	396.0	COG2274@1|root,COG2274@2|Bacteria,1MXTI@1224|Proteobacteria,1RQ97@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	abc transporter atp-binding protein	-	-	-	ko:K02021	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21	-	-	ABC_membrane
TH1_k127_6571111_0	857087.Metme_3258	0.0	1392.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008964,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0072350	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	iSFV_1184.SFV_4025	PEPcase
TH1_k127_6571111_2	1454004.AW11_02599	7.475e-27	109.0	COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,2VIP4@28216|Betaproteobacteria	28216|Betaproteobacteria	L	N-6 DNA methylase	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
TH1_k127_6585068_1	697282.Mettu_1373	5.405e-84	282.0	COG0647@1|root,COG0647@2|Bacteria,1QGX4@1224|Proteobacteria,1RRS1@1236|Gammaproteobacteria,1XE4Z@135618|Methylococcales	135618|Methylococcales	G	Belongs to the HAD-like hydrolase superfamily	-	-	3.1.3.41	ko:K01101	ko00627,ko01120,map00627,map01120	-	R03024	RC00151	ko00000,ko00001,ko01000	-	-	-	Hydrolase_6,Hydrolase_like
TH1_k127_6585068_0	697282.Mettu_1374	1.552e-173	548.0	COG2376@1|root,COG2376@2|Bacteria,1MVSR@1224|Proteobacteria,1RNRQ@1236|Gammaproteobacteria,1XE3I@135618|Methylococcales	135618|Methylococcales	G	TIGRFAM dihydroxyacetone kinase, DhaK subunit	-	-	2.7.1.121	ko:K05878	ko00561,ko01100,map00561,map01100	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000	-	-	-	Dak1
TH1_k127_6585068_2	697282.Mettu_1375	6.526e-49	177.0	COG1461@1|root,COG1461@2|Bacteria,1MXIB@1224|Proteobacteria,1RPJ7@1236|Gammaproteobacteria,1XF0H@135618|Methylococcales	135618|Methylococcales	S	TIGRFAM Dihydroxyacetone kinase	-	-	2.7.1.121	ko:K05879	ko00561,ko01100,map00561,map01100	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000	-	-	-	Dak2
TH1_k127_6587580_7	697282.Mettu_3000	1.215e-58	206.0	COG1959@1|root,COG1959@2|Bacteria,1N0E2@1224|Proteobacteria,1S915@1236|Gammaproteobacteria,1XF99@135618|Methylococcales	135618|Methylococcales	K	TIGRFAM SUF system FeS cluster assembly, Rtf2-type regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
TH1_k127_6587580_0	857087.Metme_0488	1.314e-214	676.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,1RM9U@1236|Gammaproteobacteria,1XE6M@135618|Methylococcales	135618|Methylococcales	S	PFAM Polyphosphate kinase 2	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
TH1_k127_6587580_3	686340.Metal_2030	3.226e-110	362.0	COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,1RS6A@1236|Gammaproteobacteria,1XG60@135618|Methylococcales	135618|Methylococcales	C	C-type monoheme cytochrome, which is part of the SoxAX cytochrome complex involved in sulfur oxidation. The SoxAX complex catalyzes the formation of a heterodisulfide bond between the conserved cysteine residue on a sulfur carrier SoxYZ complex subunit SoxY and thiosulfate or other inorganic sulfur substrates. This leads to the intermediary formation of conspicuous sulfur globules inside of the cells	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_6587580_11	697282.Mettu_4303	4.056e-33	131.0	COG5501@1|root,COG5501@2|Bacteria,1N097@1224|Proteobacteria,1SCTJ@1236|Gammaproteobacteria,1XFKG@135618|Methylococcales	135618|Methylococcales	S	PFAM Sulphur oxidation protein SoxZ	soxZ	-	-	ko:K17227	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxZ
TH1_k127_6587580_10	1116472.MGMO_174c00130	5.653e-34	137.0	COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,1S2ZH@1236|Gammaproteobacteria,1XFNB@135618|Methylococcales	135618|Methylococcales	S	Sulfur oxidation protein SoxY	-	-	-	ko:K17226	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxY
TH1_k127_6587580_9	1116472.MGMO_174c00120	1.905e-40	155.0	COG2010@1|root,COG2010@2|Bacteria,1N91W@1224|Proteobacteria,1SD5N@1236|Gammaproteobacteria,1XGI2@135618|Methylococcales	135618|Methylococcales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
TH1_k127_6587580_6	697282.Mettu_4305	5.186e-74	259.0	COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,1S6QS@1236|Gammaproteobacteria,1XEXZ@135618|Methylococcales	135618|Methylococcales	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
TH1_k127_6587580_2	697282.Mettu_4306	3.617e-111	364.0	COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,1RNFP@1236|Gammaproteobacteria,1XEFH@135618|Methylococcales	135618|Methylococcales	H	Phosphomethylpyrimidine kinase	-	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
TH1_k127_6587580_5	1283300.ATXB01000002_gene3128	8.201e-79	266.0	COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,1RQAB@1236|Gammaproteobacteria,1XF33@135618|Methylococcales	135618|Methylococcales	D	probably involved in intracellular septation	-	-	-	ko:K06190	-	-	-	-	ko00000	-	-	-	IspA
TH1_k127_6587580_8	697282.Mettu_1045	9.654e-41	152.0	COG2350@1|root,COG2350@2|Bacteria,1MZ9Z@1224|Proteobacteria,1S8UC@1236|Gammaproteobacteria,1XFE9@135618|Methylococcales	135618|Methylococcales	S	YCII-related domain	-	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
TH1_k127_6587580_12	686340.Metal_3000	2.062e-31	126.0	COG0271@1|root,COG0271@2|Bacteria,1QCDN@1224|Proteobacteria,1THS7@1236|Gammaproteobacteria,1XFIA@135618|Methylococcales	135618|Methylococcales	T	Belongs to the BolA IbaG family	-	-	-	ko:K05527	-	-	-	-	ko00000,ko03000	-	-	-	BolA
TH1_k127_6587580_4	697282.Mettu_1043	2.214e-86	298.0	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,1S3VR@1236|Gammaproteobacteria,1XDX1@135618|Methylococcales	135618|Methylococcales	O	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3
TH1_k127_6587580_1	697282.Mettu_2839	3.647e-150	486.0	COG2308@1|root,COG2308@2|Bacteria,1P9A0@1224|Proteobacteria,1RYUQ@1236|Gammaproteobacteria,1XFCR@135618|Methylococcales	135618|Methylococcales	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_6606219_0	243233.MCA0844	3.656e-158	502.0	COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,1RQ2J@1236|Gammaproteobacteria,1XG5Y@135618|Methylococcales	135618|Methylococcales	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	-	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_molyb
TH1_k127_6606219_1	857087.Metme_0177	2.884e-79	270.0	COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,1RS9K@1236|Gammaproteobacteria,1XF9M@135618|Methylococcales	135618|Methylococcales	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain	-	-	-	ko:K17247	-	-	-	-	ko00000	-	-	-	Ferric_reduct
TH1_k127_6606219_2	857087.Metme_0354	2.67e-58	209.0	COG0853@1|root,COG0853@2|Bacteria,1RI1B@1224|Proteobacteria,1S66E@1236|Gammaproteobacteria,1XFAU@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
TH1_k127_6615875_1	1116472.MGMO_38c00220	4.457e-83	281.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,1RMGZ@1236|Gammaproteobacteria,1XEC8@135618|Methylococcales	135618|Methylococcales	C	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TH1_k127_6615875_0	686340.Metal_1979	8.253e-159	504.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,1RMNR@1236|Gammaproteobacteria,1XERX@135618|Methylococcales	135618|Methylococcales	E	Aminotransferase class-V	sgaA	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
TH1_k127_6631373_0	243233.MCA0769	7.175e-293	905.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1XE3B@135618|Methylococcales	135618|Methylococcales	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
TH1_k127_6631373_1	243233.MCA0770	1.527e-291	902.0	COG0493@1|root,COG1144@1|root,COG0493@2|Bacteria,COG1144@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,1XE4Y@135618|Methylococcales	1236|Gammaproteobacteria	C	Glutamate synthase, NADH NADPH, small subunit	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,Fer4,Fer4_20,NAD_binding_1,Pyr_redox_2
TH1_k127_6631373_4	1283300.ATXB01000001_gene265	1.361e-27	115.0	2C4KB@1|root,32YM4@2|Bacteria,1N74A@1224|Proteobacteria,1SF3Z@1236|Gammaproteobacteria,1XFV1@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_6631373_3	857087.Metme_0825	7.393e-94	323.0	COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,1RPEZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2206 HD-GYP domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD,HD_5
TH1_k127_6631373_2	697282.Mettu_2600	1.413e-243	761.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1XE75@135618|Methylococcales	135618|Methylococcales	D	Ftsk_gamma	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
TH1_k127_6635017_5	697282.Mettu_2695	1.981e-66	229.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,1XDU7@135618|Methylococcales	135618|Methylococcales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
TH1_k127_6635017_3	187272.Mlg_1248	5.851e-71	242.0	COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,1S1Z3@1236|Gammaproteobacteria,1WYAE@135613|Chromatiales	135613|Chromatiales	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
TH1_k127_6635017_1	697282.Mettu_2697	7.425e-175	556.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,1RMUI@1236|Gammaproteobacteria,1XE4Q@135618|Methylococcales	135618|Methylococcales	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
TH1_k127_6635017_6	697282.Mettu_2698	3.741e-54	199.0	COG3063@1|root,COG3063@2|Bacteria,1MXPC@1224|Proteobacteria,1RY78@1236|Gammaproteobacteria,1XEY1@135618|Methylococcales	135618|Methylococcales	NU	Pilus biogenesis	-	-	-	ko:K02656	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	TPR_19,TPR_2,TPR_8
TH1_k127_6635017_0	697282.Mettu_2699	9.172e-201	632.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,1XDXR@135618|Methylococcales	135618|Methylococcales	J	PFAM Aminoacyl-tRNA synthetase, class II (G H P S), conserved region	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
TH1_k127_6635017_4	1116472.MGMO_86c00100	2.573e-69	241.0	COG2976@1|root,COG2976@2|Bacteria,1N117@1224|Proteobacteria,1S95P@1236|Gammaproteobacteria,1XF0Z@135618|Methylococcales	135618|Methylococcales	S	Tetratricopeptide repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	TPR_21
TH1_k127_6635017_2	697282.Mettu_2701	5.55e-142	462.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,1XE8E@135618|Methylococcales	135618|Methylococcales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamB	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
TH1_k127_6650336_3	686340.Metal_3634	1.207e-32	133.0	COG2067@1|root,COG2067@2|Bacteria,1NQ4A@1224|Proteobacteria,1RYKE@1236|Gammaproteobacteria,1XEJE@135618|Methylococcales	135618|Methylococcales	I	Putative beta-barrel porin-2, OmpL-like. bbp2	-	-	-	-	-	-	-	-	-	-	-	-	BBP2
TH1_k127_6650336_0	243233.MCA1677	1.929e-277	856.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,1XEEH@135618|Methylococcales	135618|Methylococcales	F	TIGRFAM glutamine synthetase, type I	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
TH1_k127_6650336_4	857087.Metme_0881	9.939e-17	84.0	2AW6G@1|root,31N1H@2|Bacteria,1QJTA@1224|Proteobacteria,1THUJ@1236|Gammaproteobacteria,1XFRT@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_6650336_1	686340.Metal_1653	4.212e-63	220.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1XDMY@135618|Methylococcales	135618|Methylococcales	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
TH1_k127_6650336_2	686340.Metal_1653	2.985e-42	158.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1XDMY@135618|Methylococcales	135618|Methylococcales	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
TH1_k127_6659938_1	686340.Metal_2419	8.76e-189	598.0	2C5N3@1|root,33WN9@2|Bacteria,1NWX1@1224|Proteobacteria,1THG7@1236|Gammaproteobacteria,1XDR1@135618|Methylococcales	135618|Methylococcales	S	Zeta toxin	-	-	-	-	-	-	-	-	-	-	-	-	Zeta_toxin
TH1_k127_6659938_0	686340.Metal_1410	2.229e-228	715.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,1XDV1@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
TH1_k127_6661066_2	697282.Mettu_3733	1.519e-170	537.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1XDZJ@135618|Methylococcales	135618|Methylococcales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa
TH1_k127_6661066_3	697282.Mettu_3732	8.397e-58	205.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,1RN4C@1236|Gammaproteobacteria,1XFC5@135618|Methylococcales	135618|Methylococcales	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
TH1_k127_6661066_0	686340.Metal_1518	3.579e-230	718.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1XER5@135618|Methylococcales	135618|Methylococcales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
TH1_k127_6661066_1	697282.Mettu_3730	2.033e-198	623.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1XDTA@135618|Methylococcales	135618|Methylococcales	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4,Molybdop_Fe4S4,NADH-G_4Fe-4S_3
TH1_k127_6675607_0	697282.Mettu_0186	0.0	1065.0	COG0443@1|root,COG0443@2|Bacteria,1MXX7@1224|Proteobacteria,1RP0D@1236|Gammaproteobacteria,1XE04@135618|Methylococcales	135618|Methylococcales	O	Belongs to the heat shock protein 70 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3731,HSP70
TH1_k127_6685887_1	697282.Mettu_2905	1.27e-43	167.0	COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,1RPWB@1236|Gammaproteobacteria,1XEWJ@135618|Methylococcales	135618|Methylococcales	S	Belongs to the GcvT family	-	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T
TH1_k127_6685887_0	697282.Mettu_2903	4.714e-121	396.0	COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,1RQWB@1236|Gammaproteobacteria,1XDYN@135618|Methylococcales	135618|Methylococcales	O	Cytochrome oxidase assembly	-	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
TH1_k127_6689609_1	686340.Metal_3791	9.115e-95	314.0	COG1061@1|root,COG1061@2|Bacteria,1MXFH@1224|Proteobacteria,1RP46@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KL	Type III	-	-	3.1.21.5	ko:K01156	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	ResIII
TH1_k127_6689609_0	857087.Metme_1643	0.0	1252.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,1XEMF@135618|Methylococcales	135618|Methylococcales	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
TH1_k127_6689609_3	717773.Thicy_0904	4.165e-07	51.0	COG1487@1|root,COG1487@2|Bacteria,1MZB6@1224|Proteobacteria,1S4JD@1236|Gammaproteobacteria,462GZ@72273|Thiotrichales	72273|Thiotrichales	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
TH1_k127_6689609_2	686340.Metal_0967	2.275e-66	230.0	COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,1S5WH@1236|Gammaproteobacteria,1XF9S@135618|Methylococcales	135618|Methylococcales	S	Belongs to the CinA family	-	-	3.5.1.42	ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA
TH1_k127_673521_9	857087.Metme_2080	1.052e-30	121.0	COG3145@1|root,COG3145@2|Bacteria,1RGXU@1224|Proteobacteria,1S6DD@1236|Gammaproteobacteria,1XF36@135618|Methylococcales	135618|Methylococcales	L	2OG-Fe(II) oxygenase	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2
TH1_k127_673521_6	522306.CAP2UW1_0541	1.975e-112	374.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2VMKT@28216|Betaproteobacteria	28216|Betaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TH1_k127_673521_3	697282.Mettu_2369	6.263e-183	578.0	COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,1RMAA@1236|Gammaproteobacteria,1XE6Q@135618|Methylococcales	135618|Methylococcales	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	-	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
TH1_k127_673521_4	243233.MCA1077	1.659e-170	541.0	COG2022@1|root,COG2104@1|root,COG2022@2|Bacteria,COG2104@2|Bacteria,1N0N5@1224|Proteobacteria,1RMPD@1236|Gammaproteobacteria,1XDXA@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG,ThiS
TH1_k127_673521_8	697282.Mettu_2366	3.25e-90	302.0	COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,1RMFG@1236|Gammaproteobacteria,1XEBH@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	-	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
TH1_k127_673521_0	697282.Mettu_2365	2.534e-310	962.0	COG0699@1|root,COG0699@2|Bacteria,1MXBK@1224|Proteobacteria,1RSJC@1236|Gammaproteobacteria,1XEMK@135618|Methylococcales	135618|Methylococcales	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
TH1_k127_673521_7	697282.Mettu_2364	2.797e-94	314.0	COG0461@1|root,COG0461@2|Bacteria,1MW6F@1224|Proteobacteria,1RQYG@1236|Gammaproteobacteria,1XEBX@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
TH1_k127_673521_5	857087.Metme_4440	7.03e-157	504.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,1RN6I@1236|Gammaproteobacteria,1XED6@135618|Methylococcales	135618|Methylococcales	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
TH1_k127_673521_1	686340.Metal_0758	8.069e-254	789.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria,1XE06@135618|Methylococcales	135618|Methylococcales	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
TH1_k127_673521_2	697282.Mettu_1388	2.429e-246	767.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1XDYT@135618|Methylococcales	135618|Methylococcales	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TH1_k127_673521_10	243233.MCA0099	2.404e-21	94.0	COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,1S8VY@1236|Gammaproteobacteria,1XFG3@135618|Methylococcales	135618|Methylococcales	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
TH1_k127_6740007_4	697282.Mettu_1200	5.249e-39	146.0	COG0590@1|root,COG0590@2|Bacteria,1RHM4@1224|Proteobacteria,1S4RE@1236|Gammaproteobacteria,1XF6P@135618|Methylococcales	135618|Methylococcales	FJ	deaminase zinc-binding	-	-	-	-	-	-	-	-	-	-	-	-	dCMP_cyt_deam_1
TH1_k127_6740007_3	243233.MCA1104	2.771e-68	243.0	COG0730@1|root,COG0730@2|Bacteria,1MVBS@1224|Proteobacteria,1S62V@1236|Gammaproteobacteria,1XF83@135618|Methylococcales	135618|Methylococcales	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TH1_k127_6740007_1	857087.Metme_3317	2.786e-112	366.0	COG0491@1|root,COG0491@2|Bacteria,1MURA@1224|Proteobacteria,1S2KE@1236|Gammaproteobacteria,1XGZM@135618|Methylococcales	135618|Methylococcales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TH1_k127_6740007_5	349521.HCH_06741	1.509e-16	80.0	COG3011@1|root,COG3011@2|Bacteria,1N050@1224|Proteobacteria,1S998@1236|Gammaproteobacteria,1XKUW@135619|Oceanospirillales	135619|Oceanospirillales	S	Protein of unknown function, DUF393	-	-	-	-	-	-	-	-	-	-	-	-	DUF393
TH1_k127_6740007_2	1116472.MGMO_17c00250	2.967e-72	245.0	COG2193@1|root,COG2193@2|Bacteria,1RF3C@1224|Proteobacteria,1S72I@1236|Gammaproteobacteria,1XF6G@135618|Methylococcales	135618|Methylococcales	P	Ferritin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Ferritin
TH1_k127_6740007_0	929558.SMGD1_1375	2.814e-182	582.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42MVS@68525|delta/epsilon subdivisions,2YRUW@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
TH1_k127_6771470_1	857087.Metme_1535	1.538e-69	239.0	COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,1RPU0@1236|Gammaproteobacteria,1XE1X@135618|Methylococcales	135618|Methylococcales	EH	PFAM Aminotransferase, class IV	-	-	2.6.1.21	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	-	R01148,R01582,R02459,R02851,R02924,R05053	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4
TH1_k127_6771470_0	697282.Mettu_1397	1.497e-149	482.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria,1XE3C@135618|Methylococcales	135618|Methylococcales	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
TH1_k127_6824680_3	697282.Mettu_3115	2.958e-57	200.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria,1XEE5@135618|Methylococcales	135618|Methylococcales	G	SMART Glycosyl hydrolase, family 13, subfamily, catalytic region	-	-	2.4.1.4	ko:K05341	ko00500,map00500	-	R01823	RC00028	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
TH1_k127_6824680_0	697282.Mettu_3116	5.817e-133	430.0	COG0524@1|root,COG0524@2|Bacteria,1MX38@1224|Proteobacteria,1RRWT@1236|Gammaproteobacteria,1XE9X@135618|Methylococcales	135618|Methylococcales	G	PFAM Carbohydrate purine kinase	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
TH1_k127_6824680_2	395961.Cyan7425_4809	7.208e-72	253.0	COG2199@1|root,COG3706@2|Bacteria,1G5BB@1117|Cyanobacteria,3KGBC@43988|Cyanothece	1117|Cyanobacteria	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
TH1_k127_6824680_1	697282.Mettu_3117	3.344e-79	268.0	COG0561@1|root,COG0561@2|Bacteria,1QDJR@1224|Proteobacteria,1RSEI@1236|Gammaproteobacteria,1XEIB@135618|Methylococcales	135618|Methylococcales	S	TIGRFAM HAD-superfamily hydrolase, subfamily IIB	-	-	-	-	-	-	-	-	-	-	-	-	S6PP
TH1_k127_683903_0	522306.CAP2UW1_1285	1.641e-306	958.0	COG0457@1|root,COG1413@1|root,COG0457@2|Bacteria,COG1413@2|Bacteria,1MX2U@1224|Proteobacteria,2WHVC@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Paired_CXXCH_1
TH1_k127_683903_1	472759.Nhal_1553	7.82e-108	361.0	COG3659@1|root,COG3659@2|Bacteria,1QIBX@1224|Proteobacteria	1224|Proteobacteria	M	PFAM Carbohydrate-selective porin OprB	-	-	-	ko:K07267	-	-	-	-	ko00000,ko02000	1.B.19.1	-	-	OprB
TH1_k127_6855993_1	697282.Mettu_0915	2.88e-78	264.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RN8W@1236|Gammaproteobacteria,1XDX5@135618|Methylococcales	135618|Methylococcales	BQ	PFAM Histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
TH1_k127_6855993_0	686340.Metal_0445	9.627e-115	396.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE8,EAL,GGDEF,HAMP
TH1_k127_6855993_2	1167006.UWK_00289	2.363e-36	139.0	COG3123@1|root,COG3123@2|Bacteria,1MZ8N@1224|Proteobacteria	1224|Proteobacteria	S	Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions	ppnP	GO:0003674,GO:0003824,GO:0004731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016154,GO:0016740,GO:0016757,GO:0016763,GO:0044424,GO:0044444,GO:0044464	2.4.2.1,2.4.2.2	ko:K09913	ko00230,ko00240,map00230,map00240	-	R01561,R01570,R01863,R01876,R02147,R02296,R02297	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	DUF1255
TH1_k127_6870435_1	697282.Mettu_0046	1.393e-46	170.0	COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,1S8VU@1236|Gammaproteobacteria,1XFF5@135618|Methylococcales	135618|Methylococcales	J	Belongs to the HSP15 family	hslR	-	-	ko:K04762	-	-	-	-	ko00000,ko03110	-	-	-	S4
TH1_k127_6870435_2	857087.Metme_2652	3.264e-43	160.0	COG0607@1|root,COG0607@2|Bacteria,1RHQZ@1224|Proteobacteria,1SYE5@1236|Gammaproteobacteria,1XFIQ@135618|Methylococcales	135618|Methylococcales	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TH1_k127_6870435_0	857087.Metme_0197	3.085e-208	658.0	COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,1RP2J@1236|Gammaproteobacteria,1XEQY@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the biosynthesis of agmatine from arginine	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
TH1_k127_6906025_1	1123508.JH636445_gene6574	8.366e-31	124.0	COG0845@1|root,COG0845@2|Bacteria,2J214@203682|Planctomycetes	203682|Planctomycetes	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
TH1_k127_6906025_0	1123508.JH636445_gene6575	0.0	1398.0	COG3696@1|root,COG3696@2|Bacteria,2J1ZR@203682|Planctomycetes	203682|Planctomycetes	P	AcrB/AcrD/AcrF family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
TH1_k127_6909002_4	1177179.A11A3_04500	2.852e-52	190.0	COG0424@1|root,COG0424@2|Bacteria,1RDA9@1224|Proteobacteria,1S3TQ@1236|Gammaproteobacteria,1XJND@135619|Oceanospirillales	135619|Oceanospirillales	D	Maf-like protein	maf-2	-	-	-	-	-	-	-	-	-	-	-	Maf
TH1_k127_6909002_2	686340.Metal_3155	2.59e-79	273.0	2CAM1@1|root,301FE@2|Bacteria,1RJ36@1224|Proteobacteria,1S7TX@1236|Gammaproteobacteria,1XFDM@135618|Methylococcales	135618|Methylococcales	S	Ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase
TH1_k127_6909002_1	697282.Mettu_1503	5.663e-118	382.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,1RN41@1236|Gammaproteobacteria,1XDJK@135618|Methylococcales	135618|Methylococcales	K	phosphate regulon transcriptional regulatory protein PhoB	phoB	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TH1_k127_6909002_0	697282.Mettu_1502	6.938e-163	522.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,1RN0F@1236|Gammaproteobacteria,1XDUF@135618|Methylococcales	135618|Methylococcales	T	TIGRFAM Signal transduction histidine kinase, phosphate regulon sensor PhoR	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF3329,HATPase_c,HisKA
TH1_k127_6909002_3	697282.Mettu_1208	1.198e-64	225.0	COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,1RPJP@1236|Gammaproteobacteria,1XEXS@135618|Methylococcales	135618|Methylococcales	L	Belongs to the DnaA family. HdA subfamily	-	-	-	ko:K10763	-	-	-	-	ko00000,ko03032	-	-	-	Bac_DnaA
TH1_k127_6909285_3	998674.ATTE01000001_gene102	5.824e-21	94.0	COG5611@1|root,COG5611@2|Bacteria,1N9JM@1224|Proteobacteria	1224|Proteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TH1_k127_6909285_5	765912.Thimo_0012	0.0004981	44.0	2AV75@1|root,31KXS@2|Bacteria,1RKU0@1224|Proteobacteria,1S7D1@1236|Gammaproteobacteria,1WYSC@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF1640)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1640
TH1_k127_6909285_0	686340.Metal_2496	1.218e-196	618.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1XE4F@135618|Methylococcales	135618|Methylococcales	NU	Type II/IV secretion system protein	-	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
TH1_k127_6909285_1	697282.Mettu_2654	6.235e-98	329.0	COG0739@1|root,COG0739@2|Bacteria,1RIS0@1224|Proteobacteria,1S6KP@1236|Gammaproteobacteria,1XG3T@135618|Methylococcales	135618|Methylococcales	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TH1_k127_6909285_2	697282.Mettu_1233	3.045e-61	215.0	COG0600@1|root,COG0600@2|Bacteria,1MWS0@1224|Proteobacteria,1RR15@1236|Gammaproteobacteria,1XEC4@135618|Methylococcales	135618|Methylococcales	P	PFAM Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
TH1_k127_692386_6	765912.Thimo_2622	1.534e-21	97.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1Q7PK@1224|Proteobacteria,1RSF0@1236|Gammaproteobacteria,1WWA3@135613|Chromatiales	135613|Chromatiales	L	PFAM Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_29,HTH_33
TH1_k127_692386_4	1116472.MGMO_74c00070	4.323e-59	205.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,1RPZC@1236|Gammaproteobacteria,1XDUY@135618|Methylococcales	135618|Methylococcales	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
TH1_k127_692386_3	1116472.MGMO_74c00070	1.674e-134	432.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,1RPZC@1236|Gammaproteobacteria,1XDUY@135618|Methylococcales	135618|Methylococcales	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
TH1_k127_692386_0	697282.Mettu_4274	2.462e-167	534.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1XEGW@135618|Methylococcales	135618|Methylococcales	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TH1_k127_692386_2	857087.Metme_0310	1.576e-152	491.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1XEDR@135618|Methylococcales	135618|Methylococcales	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TH1_k127_692386_1	1123392.AQWL01000009_gene1070	3.92e-155	531.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,EAL,GGDEF,PAS_4,PAS_7
TH1_k127_692386_5	697282.Mettu_3857	3.604e-37	141.0	COG1553@1|root,COG1553@2|Bacteria,1N021@1224|Proteobacteria,1S99J@1236|Gammaproteobacteria,1XFCZ@135618|Methylococcales	135618|Methylococcales	P	DsrE/DsrF-like family	dsrE	-	-	ko:K07235	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE
TH1_k127_6925770_3	686340.Metal_3599	2.578e-23	99.0	COG1791@1|root,COG1791@2|Bacteria,1RCZD@1224|Proteobacteria,1S42U@1236|Gammaproteobacteria,1XF09@135618|Methylococcales	135618|Methylococcales	S	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway	mtnD	-	1.13.11.53,1.13.11.54	ko:K08967	ko00270,ko01100,map00270,map01100	M00034	R07363,R07364	RC01866,RC02018,RC02118	ko00000,ko00001,ko00002,ko01000	-	-	-	ARD
TH1_k127_6925770_1	857087.Metme_4604	1.592e-88	299.0	COG4229@1|root,COG4229@2|Bacteria,1R3V9@1224|Proteobacteria,1RP5Y@1236|Gammaproteobacteria,1XE85@135618|Methylococcales	135618|Methylococcales	C	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)	mtnC	-	3.1.3.77	ko:K09880	ko00270,ko01100,map00270,map01100	M00034	R07395	RC02779	ko00000,ko00001,ko00002,ko01000	-	-	-	-
TH1_k127_6925770_2	298386.PBPRB0863	2.144e-79	274.0	COG2010@1|root,COG2010@2|Bacteria,1RCYF@1224|Proteobacteria,1SEBP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c mono- and diheme variants	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
TH1_k127_6925770_0	697282.Mettu_3955	1.476e-225	710.0	COG0249@1|root,COG0249@2|Bacteria,1R85X@1224|Proteobacteria,1RYSC@1236|Gammaproteobacteria,1XE12@135618|Methylococcales	135618|Methylococcales	L	PFAM DNA mismatch repair protein MutS, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	MutS_III,MutS_V
TH1_k127_6925770_4	1385515.N791_01640	3.777e-15	75.0	COG0027@1|root,COG0027@2|Bacteria,1N3KA@1224|Proteobacteria,1RNTW@1236|Gammaproteobacteria,1X41K@135614|Xanthomonadales	135614|Xanthomonadales	F	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate	purT	-	2.1.2.2	ko:K08289	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp,Epimerase
TH1_k127_6954357_7	697282.Mettu_1527	1.155e-42	159.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,1RMGD@1236|Gammaproteobacteria,1XERH@135618|Methylococcales	135618|Methylococcales	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TH1_k127_6954357_1	697282.Mettu_1526	1.563e-184	581.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,1XEU1@135618|Methylococcales	135618|Methylococcales	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
TH1_k127_6954357_2	697282.Mettu_1525	1.234e-170	546.0	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria,1XE5G@135618|Methylococcales	135618|Methylococcales	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
TH1_k127_6954357_3	697282.Mettu_1524	1.464e-164	527.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,1RMIV@1236|Gammaproteobacteria,1XEG0@135618|Methylococcales	135618|Methylococcales	M	Peptidoglycan polymerase that is essential for cell division	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
TH1_k127_6954357_4	686340.Metal_3503	1.684e-136	443.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,1RMQ3@1236|Gammaproteobacteria,1XEF4@135618|Methylococcales	135618|Methylococcales	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
TH1_k127_6954357_0	697282.Mettu_1522	3.246e-221	702.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,1XEMC@135618|Methylococcales	135618|Methylococcales	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TH1_k127_6954357_5	697282.Mettu_1521	3.403e-127	412.0	COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,1RNXK@1236|Gammaproteobacteria,1XDKM@135618|Methylococcales	135618|Methylococcales	M	Cell wall formation	murB	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0055114,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
TH1_k127_6954357_6	686340.Metal_3500	2.193e-107	354.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,1XE3P@135618|Methylococcales	135618|Methylococcales	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
TH1_k127_6960920_6	292564.Cyagr_1973	5.108e-15	79.0	2E3KF@1|root,32YIQ@2|Bacteria,1GFX6@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_6960920_4	1279015.KB908455_gene1271	1.447e-15	81.0	2E3KF@1|root,32YIQ@2|Bacteria,1NC3P@1224|Proteobacteria,1SD8X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_6960920_3	697282.Mettu_0526	3.041e-20	93.0	COG3237@1|root,COG3237@2|Bacteria	2|Bacteria	K	CsbD-like	-	-	-	-	-	-	-	-	-	-	-	-	CsbD
TH1_k127_6960920_1	1116472.MGMO_159c00070	1.434e-103	342.0	COG0664@1|root,COG0664@2|Bacteria,1RAF3@1224|Proteobacteria,1S488@1236|Gammaproteobacteria,1XG00@135618|Methylococcales	135618|Methylococcales	K	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2
TH1_k127_6960920_0	857087.Metme_2467	2.986e-116	377.0	COG0664@1|root,COG0664@2|Bacteria,1NEQM@1224|Proteobacteria,1RP0B@1236|Gammaproteobacteria,1XDPT@135618|Methylococcales	135618|Methylococcales	K	SMART HTH transcriptional regulator, Crp	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2
TH1_k127_6960920_5	697282.Mettu_0582	2.106e-15	76.0	2AW91@1|root,31N4C@2|Bacteria,1QJVT@1224|Proteobacteria,1THXE@1236|Gammaproteobacteria,1XFYD@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF3096)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3096
TH1_k127_6986496_5	697282.Mettu_1304	1.223e-110	359.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1XDRQ@135618|Methylococcales	135618|Methylococcales	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
TH1_k127_6986496_3	857087.Metme_2756	1.827e-134	443.0	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,1RM8U@1236|Gammaproteobacteria,1XEEP@135618|Methylococcales	135618|Methylococcales	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	-	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
TH1_k127_6986496_0	1283300.ATXB01000001_gene2374	2.713e-199	630.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria,1XE0F@135618|Methylococcales	135618|Methylococcales	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	ATPase,ChlI
TH1_k127_6986496_8	857087.Metme_2765	3.299e-65	228.0	COG1716@1|root,COG1716@2|Bacteria,1PGN8@1224|Proteobacteria,1SEK2@1236|Gammaproteobacteria,1XFDB@135618|Methylococcales	135618|Methylococcales	T	FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
TH1_k127_6986496_1	857087.Metme_2961	5.711e-182	578.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria,1XEF5@135618|Methylococcales	135618|Methylococcales	P	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
TH1_k127_6986496_2	697282.Mettu_1125	1.314e-138	451.0	COG1058@1|root,COG1058@2|Bacteria,1QUB2@1224|Proteobacteria,1RNXG@1236|Gammaproteobacteria,1XDQY@135618|Methylococcales	135618|Methylococcales	S	Belongs to the CinA family	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
TH1_k127_6986496_4	686340.Metal_0194	7.145e-119	390.0	COG0679@1|root,COG0679@2|Bacteria,1RCAI@1224|Proteobacteria,1S2TH@1236|Gammaproteobacteria,1XEVE@135618|Methylococcales	135618|Methylococcales	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
TH1_k127_6986496_6	243233.MCA0092	1.525e-107	360.0	COG2933@1|root,COG2933@2|Bacteria,1MWBM@1224|Proteobacteria,1RMSB@1236|Gammaproteobacteria,1XGD5@135618|Methylococcales	135618|Methylococcales	J	FtsJ-like methyltransferase	-	-	2.1.1.186	ko:K06968	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
TH1_k127_6986496_9	857087.Metme_3933	4.175e-45	170.0	COG2020@1|root,COG2020@2|Bacteria,1N936@1224|Proteobacteria,1SCXB@1236|Gammaproteobacteria,1XFKD@135618|Methylococcales	135618|Methylococcales	M	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	ICMT
TH1_k127_6986496_7	857087.Metme_3932	1.766e-106	351.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RSA2@1236|Gammaproteobacteria,1XEQX@135618|Methylococcales	135618|Methylococcales	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TH1_k127_7006293_2	477974.Daud_0199	6.796e-129	415.0	COG3587@1|root,COG3587@2|Bacteria	2|Bacteria	L	Type III restriction enzyme, res subunit	-	-	3.1.21.5	ko:K01156	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	ResIII
TH1_k127_7006293_5	335543.Sfum_2855	1.554e-81	274.0	COG1061@1|root,COG3587@1|root,COG1061@2|Bacteria,COG3587@2|Bacteria,1MXFH@1224|Proteobacteria,42YQM@68525|delta/epsilon subdivisions,2WUQJ@28221|Deltaproteobacteria,2MS77@213462|Syntrophobacterales	28221|Deltaproteobacteria	KL	PFAM Type III restriction enzyme, res subunit	-	-	3.1.21.5	ko:K01156	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	ResIII
TH1_k127_7006293_7	686340.Metal_1001	4.432e-68	238.0	COG1309@1|root,COG1309@2|Bacteria,1RG05@1224|Proteobacteria,1S7XG@1236|Gammaproteobacteria,1XEZH@135618|Methylococcales	135618|Methylococcales	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TH1_k127_7006293_4	686340.Metal_1000	4.885e-82	277.0	COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,1S465@1236|Gammaproteobacteria,1XDZA@135618|Methylococcales	135618|Methylococcales	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TH1_k127_7006293_1	396588.Tgr7_1907	1.143e-235	743.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,1WWEF@135613|Chromatiales	135613|Chromatiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
TH1_k127_7006293_6	357808.RoseRS_2431	1.439e-79	273.0	COG1136@1|root,COG1136@2|Bacteria,2G8HT@200795|Chloroflexi,375FM@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TH1_k127_7006293_0	686340.Metal_1707	1.998e-245	783.0	COG0577@1|root,COG0577@2|Bacteria,1PJZX@1224|Proteobacteria,1RU56@1236|Gammaproteobacteria,1XDTW@135618|Methylococcales	135618|Methylococcales	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TH1_k127_7006293_3	686340.Metal_1706	1.017e-84	288.0	COG5621@1|root,COG5621@2|Bacteria,1MUVF@1224|Proteobacteria,1RZ65@1236|Gammaproteobacteria,1XGI5@135618|Methylococcales	135618|Methylococcales	S	Lipocalin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9
TH1_k127_70081_3	697282.Mettu_0771	1.675e-26	113.0	COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,1S3U8@1236|Gammaproteobacteria,1XEN4@135618|Methylococcales	135618|Methylococcales	M	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	dsbC	-	5.3.4.1	ko:K03981	-	-	-	-	ko00000,ko01000,ko02044,ko03110	3.A.7.11.1	-	-	DsbC_N,Thioredoxin_2
TH1_k127_70081_1	697282.Mettu_0770	6.533e-179	571.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,1XDVY@135618|Methylococcales	135618|Methylococcales	M	zinc metalloprotease	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
TH1_k127_70081_0	857087.Metme_1640	1.019e-187	593.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,1RNNW@1236|Gammaproteobacteria,1XDM6@135618|Methylococcales	135618|Methylococcales	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
TH1_k127_70081_2	686340.Metal_2405	2.318e-95	323.0	COG4589@1|root,COG4589@2|Bacteria,1R34Q@1224|Proteobacteria,1T63B@1236|Gammaproteobacteria,1XESS@135618|Methylococcales	135618|Methylococcales	S	Belongs to the CDS family	-	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
TH1_k127_70081_4	1116472.MGMO_105c00710	1.803e-22	97.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,1RMVX@1236|Gammaproteobacteria,1XEM4@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
TH1_k127_707843_6	42256.RradSPS_0324	2.284e-33	133.0	COG0446@1|root,COG0446@2|Bacteria,2H7WY@201174|Actinobacteria	201174|Actinobacteria	P	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,Reductase_C,Rhodanese
TH1_k127_707843_3	1116472.MGMO_63c00130	3.879e-122	406.0	COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,1RMYP@1236|Gammaproteobacteria,1XEUS@135618|Methylococcales	135618|Methylococcales	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
TH1_k127_707843_0	1116472.MGMO_63c00120	1.302e-161	520.0	COG0015@1|root,COG0015@2|Bacteria,1MXNN@1224|Proteobacteria,1RS00@1236|Gammaproteobacteria,1XG71@135618|Methylococcales	135618|Methylococcales	F	Adenylosuccinate lyase C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	ADSL_C,Lyase_1
TH1_k127_707843_1	1116472.MGMO_63c00100	9.042e-151	496.0	COG0165@1|root,COG0165@2|Bacteria,1MUB6@1224|Proteobacteria,1SM3E@1236|Gammaproteobacteria,1XFZ0@135618|Methylococcales	135618|Methylococcales	E	Argininosuccinate lyase C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	ASL_C2,Lyase_1
TH1_k127_707843_4	1116472.MGMO_63c00090	9.986e-103	342.0	COG1809@1|root,COG1809@2|Bacteria,1PPRI@1224|Proteobacteria,1THYG@1236|Gammaproteobacteria,1XG1N@135618|Methylococcales	135618|Methylococcales	H	(2R)-phospho-3-sulfolactate synthase (ComA)	-	-	-	-	-	-	-	-	-	-	-	-	ComA
TH1_k127_707843_2	1116472.MGMO_63c00080	3.959e-128	417.0	COG1809@1|root,COG1809@2|Bacteria,1PPRJ@1224|Proteobacteria,1SKEQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	phosphosulfolactate synthase activity	-	-	4.4.1.19	ko:K08097	ko00680,ko01120,map00680,map01120	M00358	R07476	RC01799	ko00000,ko00001,ko00002,ko01000	-	-	-	-
TH1_k127_707843_5	1116472.MGMO_63c00070	4.905e-42	157.0	COG2057@1|root,COG2057@2|Bacteria,1MY3S@1224|Proteobacteria,1SF6X@1236|Gammaproteobacteria,1XG45@135618|Methylococcales	135618|Methylococcales	I	Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_7179750_0	243233.MCA2011	1.061e-147	479.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,1RQ4N@1236|Gammaproteobacteria,1XEUP@135618|Methylococcales	135618|Methylococcales	Q	PFAM Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2,Cu-oxidase_3
TH1_k127_7179750_2	1116472.MGMO_20c00330	2.691e-34	140.0	2FCZ5@1|root,3451T@2|Bacteria,1P1YM@1224|Proteobacteria,1SRQQ@1236|Gammaproteobacteria,1XFQE@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_7179750_1	1116472.MGMO_20c00340	9.515e-52	192.0	COG4648@1|root,COG4648@2|Bacteria,1P3DU@1224|Proteobacteria,1SR7N@1236|Gammaproteobacteria,1XFTB@135618|Methylococcales	135618|Methylococcales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_7179750_3	1283300.ATXB01000002_gene2859	1.112e-29	122.0	COG0236@1|root,COG0236@2|Bacteria,1N6RU@1224|Proteobacteria,1SCW1@1236|Gammaproteobacteria,1XFVD@135618|Methylococcales	135618|Methylococcales	IQ	Phosphopantetheine attachment site	-	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
TH1_k127_7179979_2	857087.Metme_1323	8.283e-35	135.0	COG4191@1|root,COG4191@2|Bacteria,1MU55@1224|Proteobacteria,1RQ5N@1236|Gammaproteobacteria,1XFZY@135618|Methylococcales	135618|Methylococcales	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
TH1_k127_7179979_0	697282.Mettu_2358	4.181e-131	419.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,1RN3K@1236|Gammaproteobacteria,1XEGG@135618|Methylococcales	135618|Methylococcales	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
TH1_k127_7179979_1	686340.Metal_3183	6.879e-94	315.0	COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,1RNF8@1236|Gammaproteobacteria,1XED0@135618|Methylococcales	135618|Methylococcales	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
TH1_k127_7188998_0	697282.Mettu_3869	5.768e-268	834.0	COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,1S4M3@1236|Gammaproteobacteria,1XDIX@135618|Methylococcales	135618|Methylococcales	E	PFAM Bacterial extracellular solute-binding	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
TH1_k127_7188998_1	686340.Metal_0224	6.23e-94	314.0	COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,1S8RQ@1236|Gammaproteobacteria,1XFC3@135618|Methylococcales	135618|Methylococcales	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
TH1_k127_7188998_2	1049564.TevJSym_ah00220	9.514e-23	101.0	COG1993@1|root,COG1993@2|Bacteria,1N8TP@1224|Proteobacteria,1SDYH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
TH1_k127_7188998_3	697282.Mettu_0421	5.682e-06	48.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1S222@1236|Gammaproteobacteria,1XDKY@135618|Methylococcales	135618|Methylococcales	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
TH1_k127_7223352_4	756272.Plabr_3020	6.597e-21	93.0	COG1156@1|root,COG1156@2|Bacteria,2J2EX@203682|Planctomycetes	203682|Planctomycetes	C	ATP synthase alpha/beta family, beta-barrel domain	-	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
TH1_k127_7223352_3	314345.SPV1_09133	1.573e-24	111.0	COG0584@1|root,COG0584@2|Bacteria	2|Bacteria	C	glycerophosphodiester phosphodiesterase activity	glpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
TH1_k127_7223352_2	768671.ThimaDRAFT_0224	7.677e-38	162.0	COG3064@1|root,COG3064@2|Bacteria,1MXPS@1224|Proteobacteria,1RQIV@1236|Gammaproteobacteria,1X0HY@135613|Chromatiales	135613|Chromatiales	M	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
TH1_k127_7223352_1	909663.KI867150_gene2891	1.858e-89	306.0	COG4786@1|root,COG4786@2|Bacteria,1MZXB@1224|Proteobacteria,42MTK@68525|delta/epsilon subdivisions,2WM8U@28221|Deltaproteobacteria,2MQWV@213462|Syntrophobacterales	28221|Deltaproteobacteria	N	Protein of unknown function (DUF2950)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2950
TH1_k127_7223352_0	1026882.MAMP_02424	3.083e-101	334.0	COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,1RPSW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Phosphoketolase	xfp	GO:0003674,GO:0003824,GO:0008150,GO:0009758	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
TH1_k127_7282853_1	1116472.MGMO_83c00160	2.716e-90	300.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria,1XESH@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
TH1_k127_7282853_0	697282.Mettu_2814	1.634e-224	707.0	COG2132@1|root,COG2132@2|Bacteria,1R8SR@1224|Proteobacteria,1SDTA@1236|Gammaproteobacteria,1XERJ@135618|Methylococcales	135618|Methylococcales	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2,Cu-oxidase_3
TH1_k127_7282853_2	1116472.MGMO_141c00130	7.473e-81	276.0	COG3794@1|root,COG3794@2|Bacteria,1RF7V@1224|Proteobacteria,1S4VA@1236|Gammaproteobacteria,1XG9R@135618|Methylococcales	135618|Methylococcales	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_7289356_3	697282.Mettu_1594	6.419e-67	229.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,1RNKK@1236|Gammaproteobacteria,1XEDQ@135618|Methylococcales	135618|Methylococcales	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
TH1_k127_7289356_0	686340.Metal_1376	7.815e-225	732.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria,1XDTR@135618|Methylococcales	135618|Methylococcales	G	alpha beta alpha domain I	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TH1_k127_7289356_4	634499.EpC_00760	4.754e-61	213.0	COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,1S233@1236|Gammaproteobacteria,3X6ET@551|Erwinia	1236|Gammaproteobacteria	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019103,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0022607,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0051259,GO:0051260,GO:0055086,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901136,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
TH1_k127_7289356_1	857087.Metme_3323	1.135e-170	543.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,1XE1E@135618|Methylococcales	135618|Methylococcales	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
TH1_k127_7289356_2	697282.Mettu_1830	1.332e-111	363.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,1RP86@1236|Gammaproteobacteria,1XDWW@135618|Methylococcales	135618|Methylococcales	E	Belongs to the UPF0758 family	-	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
TH1_k127_7310339_2	1116472.MGMO_77c00210	2.79e-131	428.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,1RMGD@1236|Gammaproteobacteria,1XERH@135618|Methylococcales	135618|Methylococcales	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TH1_k127_7310339_1	686340.Metal_3508	3.628e-173	556.0	COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,1RMD6@1236|Gammaproteobacteria,1XE2H@135618|Methylococcales	135618|Methylococcales	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TH1_k127_7310339_0	697282.Mettu_1529	3.454e-232	733.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,1XDU6@135618|Methylococcales	135618|Methylococcales	M	Catalyzes cross-linking of the peptidoglycan cell wall at the division septum	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
TH1_k127_7310339_7	396588.Tgr7_0762	3.413e-09	61.0	COG3116@1|root,COG3116@2|Bacteria,1NI3C@1224|Proteobacteria,1SGSB@1236|Gammaproteobacteria,1WZ00@135613|Chromatiales	135613|Chromatiales	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsL	-	-	ko:K03586	-	-	-	-	ko00000,ko03036	-	-	-	FtsL
TH1_k127_7310339_3	697282.Mettu_1531	5.559e-114	375.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,1RM7M@1236|Gammaproteobacteria,1XE2P@135618|Methylococcales	135618|Methylococcales	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
TH1_k127_7310339_4	857087.Metme_0268	6.492e-72	245.0	COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,1S63F@1236|Gammaproteobacteria,1XF1V@135618|Methylococcales	135618|Methylococcales	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
TH1_k127_7310339_8	314287.GB2207_11628	7.581e-09	59.0	2DMTH@1|root,32TKP@2|Bacteria,1N4TE@1224|Proteobacteria,1S9K6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_7310339_6	1111728.ATYS01000013_gene4926	3.092e-10	62.0	2E9J1@1|root,333RY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_7310339_5	697282.Mettu_2674	2.01e-46	171.0	COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,1RMPG@1236|Gammaproteobacteria,1XE0Q@135618|Methylococcales	135618|Methylococcales	L	DNA helicase	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind
TH1_k127_7330814_2	697282.Mettu_2978	7.182e-99	331.0	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RM8Z@1236|Gammaproteobacteria,1XDPP@135618|Methylococcales	135618|Methylococcales	O	HflC and HflK could regulate a protease	-	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
TH1_k127_7330814_1	697282.Mettu_2979	1.036e-167	535.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RMUG@1236|Gammaproteobacteria,1XDNN@135618|Methylococcales	135618|Methylococcales	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
TH1_k127_7330814_0	697282.Mettu_2980	6.241e-168	534.0	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria,1XDYP@135618|Methylococcales	135618|Methylococcales	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
TH1_k127_7340552_9	192952.MM_3105	1.261e-05	49.0	COG1513@1|root,arCOG01488@2157|Archaea	2157|Archaea	P	CMP dCMP deaminase, zinc-binding	-	-	3.5.4.1	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922	RC00074,RC00514,RC00809	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
TH1_k127_7340552_8	1283300.ATXB01000001_gene2234	6.255e-07	53.0	COG2807@1|root,COG2807@2|Bacteria,1QU0F@1224|Proteobacteria,1T1JZ@1236|Gammaproteobacteria,1XETP@135618|Methylococcales	135618|Methylococcales	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TH1_k127_7340552_0	857087.Metme_2699	4.24e-272	842.0	COG2807@1|root,COG2807@2|Bacteria,1QU0F@1224|Proteobacteria,1T1JZ@1236|Gammaproteobacteria,1XETP@135618|Methylococcales	135618|Methylococcales	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TH1_k127_7340552_7	697282.Mettu_3560	2.165e-60	209.0	COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,1S675@1236|Gammaproteobacteria,1XF7Y@135618|Methylococcales	135618|Methylococcales	C	Iron-sulfur cluster insertion protein ErpA	erpA	-	-	ko:K15724	-	-	-	-	ko00000	-	-	-	Fe-S_biosyn
TH1_k127_7340552_1	697282.Mettu_3557	2.225e-213	667.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,1RPKC@1236|Gammaproteobacteria,1XDVM@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
TH1_k127_7340552_5	857087.Metme_1141	1.178e-73	250.0	COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,1S68X@1236|Gammaproteobacteria,1XEYU@135618|Methylococcales	135618|Methylococcales	S	EVE domain	-	-	-	-	-	-	-	-	-	-	-	-	EVE
TH1_k127_7340552_6	697282.Mettu_1548	1.778e-62	219.0	COG1853@1|root,COG1853@2|Bacteria,1QSGJ@1224|Proteobacteria,1S5ST@1236|Gammaproteobacteria,1XF9G@135618|Methylococcales	135618|Methylococcales	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
TH1_k127_7340552_3	857087.Metme_4340	1.205e-111	367.0	COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,1RMBU@1236|Gammaproteobacteria,1XE1T@135618|Methylococcales	135618|Methylococcales	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
TH1_k127_7340552_4	686340.Metal_3554	1.552e-79	272.0	COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,1S3PG@1236|Gammaproteobacteria,1XF2H@135618|Methylococcales	135618|Methylococcales	V	PFAM N-acetylmuramoyl-L-alanine amidase	ampD	-	3.5.1.28	ko:K03806	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	Amidase_2
TH1_k127_7340552_2	713586.KB900536_gene1619	9.389e-118	394.0	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,1WXYV@135613|Chromatiales	135613|Chromatiales	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella	-	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K18691	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	SBP_bac_3,SLT
TH1_k127_7351643_17	697282.Mettu_3018	4.067e-11	64.0	COG0665@1|root,COG0665@2|Bacteria,1QJKZ@1224|Proteobacteria,1THMM@1236|Gammaproteobacteria,1XEVH@135618|Methylococcales	135618|Methylococcales	E	PFAM FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
TH1_k127_7351643_8	697282.Mettu_3018	7.002e-86	293.0	COG0665@1|root,COG0665@2|Bacteria,1QJKZ@1224|Proteobacteria,1THMM@1236|Gammaproteobacteria,1XEVH@135618|Methylococcales	135618|Methylococcales	E	PFAM FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
TH1_k127_7351643_1	857087.Metme_2366	1.33e-288	896.0	COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1RSFG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
TH1_k127_7351643_12	857087.Metme_2365	1.102e-65	231.0	28P4X@1|root,2ZC02@2|Bacteria,1RB0B@1224|Proteobacteria,1S2S5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2764
TH1_k127_7351643_10	857087.Metme_2364	5.247e-73	252.0	COG1390@1|root,COG1390@2|Bacteria,1MYFC@1224|Proteobacteria,1S1YK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	-	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	-
TH1_k127_7351643_11	857087.Metme_2363	8.597e-71	243.0	COG0636@1|root,COG0636@2|Bacteria,1RB4B@1224|Proteobacteria,1S2I4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	ATP synthase, subunit	atpK	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
TH1_k127_7351643_3	857087.Metme_2362	3.618e-191	614.0	COG1269@1|root,COG1269@2|Bacteria,1QGFB@1224|Proteobacteria,1RY40@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
TH1_k127_7351643_13	1049564.TevJSym_aa02400	1.455e-53	195.0	COG1394@1|root,COG1394@2|Bacteria,1RJCN@1224|Proteobacteria,1S7QV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	subunit D	-	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
TH1_k127_7351643_0	1249627.D779_2430	5.966e-312	970.0	COG1449@1|root,COG1449@2|Bacteria,1R18I@1224|Proteobacteria,1SGAD@1236|Gammaproteobacteria,1X04T@135613|Chromatiales	135613|Chromatiales	G	Glycosyl hydrolase family 57	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
TH1_k127_7351643_6	686340.Metal_0248	6.357e-114	372.0	COG1656@1|root,COG1656@2|Bacteria,1R442@1224|Proteobacteria,1S4UH@1236|Gammaproteobacteria,1XEJU@135618|Methylococcales	135618|Methylococcales	S	Mut7-C ubiquitin	-	-	-	-	-	-	-	-	-	-	-	-	Mut7-C,Ub-Mut7C
TH1_k127_7351643_15	857087.Metme_3552	2.333e-20	96.0	COG1198@1|root,COG1198@2|Bacteria	2|Bacteria	L	DNA replication, synthesis of RNA primer	yfgJ	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	zinc-ribbons_6
TH1_k127_7351643_14	686340.Metal_1004	1.077e-47	176.0	2AUBI@1|root,31JZ8@2|Bacteria,1QIAB@1224|Proteobacteria,1TG4G@1236|Gammaproteobacteria,1XFK8@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_7351643_7	697282.Mettu_2950	4.016e-101	332.0	COG1392@1|root,COG1392@2|Bacteria,1PKQF@1224|Proteobacteria,1SMFE@1236|Gammaproteobacteria,1XG8F@135618|Methylococcales	135618|Methylococcales	P	Pit accessory protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_7351643_2	697282.Mettu_2949	2.751e-197	619.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,1RP0Q@1236|Gammaproteobacteria,1XFG4@135618|Methylococcales	135618|Methylococcales	P	Phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
TH1_k127_7351643_16	686340.Metal_0844	2.791e-17	82.0	2AW8E@1|root,31M5C@2|Bacteria,1QJ09@1224|Proteobacteria,1TGXH@1236|Gammaproteobacteria,1XGW0@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_7351643_5	697282.Mettu_3879	5.638e-123	400.0	COG2218@1|root,COG2218@2|Bacteria,1MUUQ@1224|Proteobacteria,1S19G@1236|Gammaproteobacteria,1XEVQ@135618|Methylococcales	135618|Methylococcales	C	TIGRFAM formylmethanofuran dehydrogenase subunit C	-	-	1.2.7.12	ko:K00202	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	GXGXG
TH1_k127_7351643_4	686340.Metal_0412	1.319e-171	542.0	COG2037@1|root,COG2037@2|Bacteria,1MVSD@1224|Proteobacteria,1SKSG@1236|Gammaproteobacteria,1XE1H@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)	ffsA	-	2.3.1.101	ko:K00672	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03390	RC00197,RC00870,RC02881	ko00000,ko00001,ko00002,ko01000	-	-	-	FTR,FTR_C
TH1_k127_7351643_9	857087.Metme_0669	1.523e-82	276.0	COG1229@1|root,COG1229@2|Bacteria,1NX13@1224|Proteobacteria,1RZ5G@1236|Gammaproteobacteria,1XDSE@135618|Methylococcales	135618|Methylococcales	C	TIGRFAM Formylmethanofuran dehydrogenase, subunit A	-	-	1.2.7.12	ko:K00200	ko00680,ko01100,ko01120,ko01130,ko01200,map00680,map01100,map01120,map01130,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_3
TH1_k127_7356403_0	697282.Mettu_0796	5.979e-184	582.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,1RN3V@1236|Gammaproteobacteria,1XE6P@135618|Methylococcales	135618|Methylococcales	FP	Belongs to the GppA Ppx family	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
TH1_k127_7356403_1	697282.Mettu_0795	1.175e-140	452.0	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,1RMC5@1236|Gammaproteobacteria,1XEVT@135618|Methylococcales	135618|Methylococcales	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TH1_k127_7356403_2	686340.Metal_1993	7.987e-76	257.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,1RP0Z@1236|Gammaproteobacteria,1XEBZ@135618|Methylococcales	135618|Methylococcales	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TH1_k127_7363114_2	857087.Metme_4108	9.376e-82	280.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1XE9U@135618|Methylococcales	135618|Methylococcales	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
TH1_k127_7363114_0	686340.Metal_3852	0.0	1092.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1XEHC@135618|Methylococcales	135618|Methylococcales	P	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	E1-E2_ATPase,Hydrolase
TH1_k127_7363114_1	1198232.CYCME_2420	1.718e-94	322.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,1RQJW@1236|Gammaproteobacteria,460Z5@72273|Thiotrichales	72273|Thiotrichales	P	Voltage gated chloride channel	-	-	-	-	-	-	-	-	-	-	-	-	Voltage_CLC
TH1_k127_7363114_3	686340.Metal_2942	2.418e-14	73.0	COG0475@1|root,COG0475@2|Bacteria,1N2RV@1224|Proteobacteria,1THWD@1236|Gammaproteobacteria,1XFVR@135618|Methylococcales	135618|Methylococcales	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
TH1_k127_74057_0	697282.Mettu_1514	2.61e-152	484.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1XE08@135618|Methylococcales	135618|Methylococcales	C	NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding	-	-	1.12.1.2	ko:K18005	-	-	-	-	ko00000,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S
TH1_k127_74057_1	697282.Mettu_1513	3.307e-126	406.0	COG3383@1|root,COG3383@2|Bacteria,1MXTC@1224|Proteobacteria,1RZDX@1236|Gammaproteobacteria,1XER2@135618|Methylococcales	135618|Methylococcales	C	PFAM NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding	-	-	1.12.1.2	ko:K18006	-	-	-	-	ko00000,ko01000	-	-	-	Fer2_4,Fer4_15,NADH-G_4Fe-4S_3
TH1_k127_74057_3	697282.Mettu_1512	1.27e-106	346.0	COG1941@1|root,COG1941@2|Bacteria,1NS0E@1224|Proteobacteria,1RW0G@1236|Gammaproteobacteria,1XDM0@135618|Methylococcales	135618|Methylococcales	C	PFAM NADH ubiquinone	-	-	1.12.1.2	ko:K18007	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_q6
TH1_k127_74057_2	857087.Metme_2390	1.055e-108	367.0	COG2911@1|root,COG2911@2|Bacteria,1NHQB@1224|Proteobacteria,1SVEG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	Porin_2
TH1_k127_74057_4	1121015.N789_01230	1.338e-49	181.0	COG2153@1|root,COG2153@2|Bacteria,1MZ86@1224|Proteobacteria,1S8SK@1236|Gammaproteobacteria,1X5TH@135614|Xanthomonadales	135614|Xanthomonadales	S	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
TH1_k127_740775_3	857087.Metme_1498	1.202e-29	118.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,1RMG9@1236|Gammaproteobacteria,1XETJ@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
TH1_k127_740775_0	686340.Metal_2822	3.519e-94	313.0	COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,1RNQZ@1236|Gammaproteobacteria,1XDUJ@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
TH1_k127_740775_4	243233.MCA1231	8.18e-26	119.0	COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,1RQWA@1236|Gammaproteobacteria,1XFEG@135618|Methylococcales	135618|Methylococcales	D	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	cpoB	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TolA_bind_tri
TH1_k127_740775_1	857087.Metme_1495	3.185e-57	205.0	COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,1S8RG@1236|Gammaproteobacteria,1XF3T@135618|Methylococcales	135618|Methylococcales	M	Belongs to the ompA family	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
TH1_k127_740775_2	1116472.MGMO_52c00290	2.272e-48	175.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1XEH5@135618|Methylococcales	135618|Methylococcales	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
TH1_k127_7410092_4	111781.Lepto7376_1993	1.977e-12	67.0	2DCT2@1|root,32U08@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PRiA4_ORF3
TH1_k127_7410092_0	697282.Mettu_3977	0.0	2280.0	COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,1RQ27@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	narG	-	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Molybdopterin,Molydop_binding,Nitr_red_alph_N
TH1_k127_7410092_1	697282.Mettu_3976	4.253e-290	897.0	COG1140@1|root,COG1140@2|Bacteria,1QZP4@1224|Proteobacteria	1224|Proteobacteria	C	4Fe-4S dicluster domain	-	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K16965,ko:K17051	ko00920,map00920	-	R09500	RC02555	ko00000,ko00001,ko02000	5.A.3.8	-	-	Fer4_11,Nitr_red_bet_C
TH1_k127_7410092_3	697282.Mettu_3974	8.263e-76	261.0	COG2180@1|root,COG2180@2|Bacteria,1MY4E@1224|Proteobacteria,1RQ23@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Nitrate reductase	narJ	-	-	ko:K00373	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Nitrate_red_del
TH1_k127_7410092_2	697282.Mettu_3973	1.826e-111	363.0	COG2181@1|root,COG2181@2|Bacteria,1MXGZ@1224|Proteobacteria,1RPTD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	nitrate reductase, gamma subunit	narI	-	1.7.5.1	ko:K00374	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Nitrate_red_gam
TH1_k127_7410092_5	857087.Metme_3420	9.839e-06	52.0	2C3QV@1|root,2Z7YP@2|Bacteria,1MXAM@1224|Proteobacteria,1RNIA@1236|Gammaproteobacteria,1XEFQ@135618|Methylococcales	135618|Methylococcales	S	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
TH1_k127_7430048_2	1385935.N836_02475	5.25e-12	70.0	COG0513@1|root,COG0513@2|Bacteria,1G0VD@1117|Cyanobacteria,1H785@1150|Oscillatoriales	1117|Cyanobacteria	L	Belongs to the DEAD box helicase family	deaD	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
TH1_k127_7430048_1	857087.Metme_1898	4.878e-89	298.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,1RMMG@1236|Gammaproteobacteria,1XEZN@135618|Methylococcales	135618|Methylococcales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TH1_k127_7430048_0	697282.Mettu_4258	2.128e-100	331.0	COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,1RPBP@1236|Gammaproteobacteria,1XET3@135618|Methylococcales	135618|Methylococcales	J	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
TH1_k127_7447145_1	686340.Metal_3650	2.39e-57	203.0	COG4208@1|root,COG4208@2|Bacteria,1MV8X@1224|Proteobacteria,1RNZK@1236|Gammaproteobacteria,1XES7@135618|Methylococcales	135618|Methylococcales	P	ABC transporter permease protein	cysW	-	-	ko:K02047	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	BPD_transp_1
TH1_k127_7447145_0	1007105.PT7_1069	5.101e-104	346.0	COG0555@1|root,COG0555@2|Bacteria,1QTTU@1224|Proteobacteria,2VHKY@28216|Betaproteobacteria,3T2NW@506|Alcaligenaceae	28216|Betaproteobacteria	P	sulfate transport system, permease	cysT	-	-	ko:K02046,ko:K15496	ko00920,ko02010,map00920,map02010	M00185,M00423	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3,3.A.1.6.5	-	-	BPD_transp_1
TH1_k127_7448379_0	335543.Sfum_1457	1.677e-224	705.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,2MR4N@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	Protein export membrane protein	bepE	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
TH1_k127_7448379_1	56780.SYN_02946	2.74e-133	441.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42NKZ@68525|delta/epsilon subdivisions,2WK44@28221|Deltaproteobacteria,2MQ56@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	MFS_1,OEP
TH1_k127_7448379_2	857087.Metme_2380	3.829e-130	420.0	COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,1RMK2@1236|Gammaproteobacteria,1XESD@135618|Methylococcales	135618|Methylococcales	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
TH1_k127_7448379_4	686340.Metal_3130	1.42e-76	258.0	COG1376@1|root,COG1376@2|Bacteria,1RHBG@1224|Proteobacteria,1S6DY@1236|Gammaproteobacteria,1XF6M@135618|Methylococcales	135618|Methylococcales	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
TH1_k127_7448379_3	1116472.MGMO_88c00160	5.441e-78	264.0	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,1RN1D@1236|Gammaproteobacteria,1XDWN@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA	rlmD	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
TH1_k127_7457012_1	697282.Mettu_3850	5.391e-94	316.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1XEKH@135618|Methylococcales	135618|Methylococcales	L	Bacterial DNA polymerase III, alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
TH1_k127_7457012_3	1225785.CM001983_gene933	2.33e-65	228.0	COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,1RQ4B@1236|Gammaproteobacteria,2JE0R@204037|Dickeya	1236|Gammaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
TH1_k127_7457012_0	857087.Metme_2639	5.828e-139	445.0	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,1RPHB@1236|Gammaproteobacteria,1XECT@135618|Methylococcales	135618|Methylococcales	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
TH1_k127_7457012_2	243233.MCA2445	1.269e-69	241.0	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,1S63E@1236|Gammaproteobacteria,1XEYJ@135618|Methylococcales	135618|Methylococcales	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
TH1_k127_7457012_5	697282.Mettu_2892	1.665e-60	214.0	COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,1RQIE@1236|Gammaproteobacteria,1XF7V@135618|Methylococcales	135618|Methylococcales	M	Belongs to the skp family	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
TH1_k127_7457012_4	686340.Metal_0143	2.15e-64	224.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1XDRZ@135618|Methylococcales	135618|Methylococcales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
TH1_k127_7464424_2	697282.Mettu_0335	1.207e-84	291.0	COG0741@1|root,COG0741@2|Bacteria,1MWRW@1224|Proteobacteria,1S084@1236|Gammaproteobacteria,1XEU5@135618|Methylococcales	135618|Methylococcales	M	lytic transglycosylase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_7464424_3	857087.Metme_4096	4.522e-63	222.0	COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,1S3MU@1236|Gammaproteobacteria,1XF19@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
TH1_k127_7464424_5	697282.Mettu_2960	0.0008684	44.0	COG1896@1|root,COG1896@2|Bacteria,1MVGJ@1224|Proteobacteria,1RSED@1236|Gammaproteobacteria,1XE1Q@135618|Methylococcales	135618|Methylococcales	S	PFAM Metal-dependent phosphohydrolase, HD region, subdomain	-	-	3.1.3.89	ko:K08722	ko00240,ko01100,map00240,map01100	-	R01569,R01664,R01968,R02088,R02102,R10776	RC00017	ko00000,ko00001,ko01000	-	-	-	HD_3
TH1_k127_7464424_0	395493.BegalDRAFT_3036	6.98e-220	699.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPCU@1236|Gammaproteobacteria,45ZXG@72273|Thiotrichales	72273|Thiotrichales	S	ABC transporter	-	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
TH1_k127_7464424_1	709797.CSIRO_3607	3.718e-95	318.0	COG1409@1|root,COG1409@2|Bacteria,1MVDW@1224|Proteobacteria,2TQNM@28211|Alphaproteobacteria,3JS85@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
TH1_k127_7464424_4	240016.ABIZ01000001_gene3119	3.466e-21	96.0	COG0454@1|root,COG0456@2|Bacteria,46WBI@74201|Verrucomicrobia,2IVW6@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
TH1_k127_7469186_3	1380355.JNIJ01000021_gene3726	7.951e-118	386.0	COG1018@1|root,COG1018@2|Bacteria,1MY2Q@1224|Proteobacteria,2U0WY@28211|Alphaproteobacteria,3JVZN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Oxidoreductase NAD-binding domain	hcr	-	1.17.1.1	ko:K00523,ko:K21832	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
TH1_k127_7469186_1	686340.Metal_1439	5.998e-261	809.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1XE4S@135618|Methylococcales	135618|Methylococcales	J	ribonuclease, Rne Rng family	-	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
TH1_k127_7469186_0	697282.Mettu_2467	1.778e-270	877.0	COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria,1XDVI@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
TH1_k127_7469186_2	697282.Mettu_2468	7.526e-143	456.0	COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,1RNVZ@1236|Gammaproteobacteria,1XEP3@135618|Methylococcales	135618|Methylococcales	S	Carbon-nitrogen hydrolase	-	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
TH1_k127_7469186_4	697282.Mettu_2470	4.838e-33	129.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,1RMA5@1236|Gammaproteobacteria,1XE3Y@135618|Methylococcales	135618|Methylococcales	S	modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
TH1_k127_7472127_1	857087.Metme_3206	1.191e-89	298.0	COG0025@1|root,COG1226@1|root,COG0025@2|Bacteria,COG1226@2|Bacteria,1QTUE@1224|Proteobacteria,1T1HJ@1236|Gammaproteobacteria,1XG26@135618|Methylococcales	135618|Methylococcales	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
TH1_k127_7472127_0	697282.Mettu_3118	0.0	1084.0	COG0438@1|root,COG0561@1|root,COG0438@2|Bacteria,COG0561@2|Bacteria,1MWVX@1224|Proteobacteria,1RSR5@1236|Gammaproteobacteria,1XDS7@135618|Methylococcales	135618|Methylococcales	M	Sucrose phosphate synthase, sucrose phosphatase-like	-	-	2.4.1.14	ko:K00696	ko00500,ko01100,map00500,map01100	-	R00766	RC00005,RC00028,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1,S6PP
TH1_k127_7472127_2	1116472.MGMO_87c00020	3.371e-37	141.0	COG0561@1|root,COG0561@2|Bacteria,1QDJR@1224|Proteobacteria,1RSEI@1236|Gammaproteobacteria,1XEIB@135618|Methylococcales	135618|Methylococcales	S	TIGRFAM HAD-superfamily hydrolase, subfamily IIB	-	-	-	-	-	-	-	-	-	-	-	-	S6PP
TH1_k127_7491345_2	1116472.MGMO_115c00100	1.167e-145	465.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,1RNWJ@1236|Gammaproteobacteria,1XEK1@135618|Methylococcales	135618|Methylococcales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
TH1_k127_7491345_1	686340.Metal_3771	3.082e-301	927.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1XEKJ@135618|Methylococcales	135618|Methylococcales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	-	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
TH1_k127_7491345_8	697282.Mettu_2152	1.963e-56	201.0	COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria,1XF4Q@135618|Methylococcales	135618|Methylococcales	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
TH1_k127_7491345_7	697282.Mettu_2151	4.602e-63	220.0	COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,1S402@1236|Gammaproteobacteria,1XF7Q@135618|Methylococcales	135618|Methylococcales	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
TH1_k127_7491345_9	1116472.MGMO_115c00060	2.062e-45	165.0	COG0636@1|root,32S3K@2|Bacteria,1N1NA@1224|Proteobacteria,1S9MD@1236|Gammaproteobacteria,1XFHC@135618|Methylococcales	135618|Methylococcales	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	-	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
TH1_k127_7491345_4	1116472.MGMO_115c00050	2.57e-138	443.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,1XE4P@135618|Methylococcales	135618|Methylococcales	C	it plays a direct role in the translocation of protons across the membrane	-	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
TH1_k127_7491345_12	697282.Mettu_2148	4.829e-32	128.0	COG3312@1|root,COG3312@2|Bacteria,1NDM1@1224|Proteobacteria,1THRJ@1236|Gammaproteobacteria,1XFG2@135618|Methylococcales	135618|Methylococcales	C	ATP synthase I chain	-	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATP-synt_I
TH1_k127_7491345_5	243233.MCA2501	2.994e-82	280.0	2C8FP@1|root,340K8@2|Bacteria,1NXGW@1224|Proteobacteria,1THKW@1236|Gammaproteobacteria,1XESB@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_7491345_3	857087.Metme_0394	8.482e-142	452.0	28NX2@1|root,2ZBUV@2|Bacteria,1RD3N@1224|Proteobacteria,1SP2D@1236|Gammaproteobacteria,1XETI@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_7491345_6	857087.Metme_3353	5.524e-81	273.0	COG3812@1|root,COG3812@2|Bacteria,1RGUV@1224|Proteobacteria,1S24N@1236|Gammaproteobacteria,1XF7B@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF1993)	-	-	-	ko:K09983	-	-	-	-	ko00000	-	-	-	DUF1993
TH1_k127_7491345_11	686340.Metal_0625	3.181e-38	144.0	COG3905@1|root,COG3905@2|Bacteria,1PPSD@1224|Proteobacteria,1TCGN@1236|Gammaproteobacteria,1XGTS@135618|Methylococcales	135618|Methylococcales	K	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_7491345_10	686340.Metal_0626	1.084e-41	154.0	COG3668@1|root,COG3668@2|Bacteria,1PZJZ@1224|Proteobacteria,1TB9H@1236|Gammaproteobacteria,1XFXW@135618|Methylococcales	135618|Methylococcales	S	TIGRFAM Addiction module toxin, RelE StbE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
TH1_k127_7491345_0	243233.MCA0936	0.0	1102.0	COG1203@1|root,COG1203@2|Bacteria,1MX99@1224|Proteobacteria,1RMM0@1236|Gammaproteobacteria,1XFCE@135618|Methylococcales	135618|Methylococcales	L	helicase Cas3	-	-	-	ko:K07012	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DEAD
TH1_k127_7491345_13	629773.AORY01000015_gene1145	6.852e-21	99.0	28JFH@1|root,2Z99F@2|Bacteria,1PJEF@1224|Proteobacteria,2U0IH@28211|Alphaproteobacteria,2K9US@204457|Sphingomonadales	204457|Sphingomonadales	S	TIGRFAM CRISPR-associated protein, Cse1 family	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_7492199_1	261292.Nit79A3_0967	2.613e-110	358.0	COG3568@1|root,COG3568@2|Bacteria	2|Bacteria	N	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,CBM_4_9,Exo_endo_phos,F5_F8_type_C,FIVAR,Laminin_G_3,Lyase_8,Lyase_8_C,Lyase_8_N
TH1_k127_7492199_2	153948.NAL212_2649	3.358e-109	356.0	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2VHCD@28216|Betaproteobacteria,371WB@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Glutathione S-transferase, N-terminal domain	gst7	-	2.5.1.18	ko:K00799,ko:K11209	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N,GST_N_3
TH1_k127_7492199_0	261292.Nit79A3_0968	2.344e-111	360.0	COG0477@1|root,COG2814@2|Bacteria,1QV32@1224|Proteobacteria,2WA0K@28216|Betaproteobacteria,3746I@32003|Nitrosomonadales	28216|Betaproteobacteria	EGP	PFAM Major facilitator superfamily MFS-1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TH1_k127_7493326_4	686340.Metal_3570	4.072e-32	125.0	COG0223@1|root,COG1024@1|root,COG0223@2|Bacteria,COG1024@2|Bacteria,1MWYJ@1224|Proteobacteria,1RZSE@1236|Gammaproteobacteria,1XG82@135618|Methylococcales	135618|Methylococcales	IJ	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1,Formyl_trans_C,Formyl_trans_N
TH1_k127_7493326_2	686340.Metal_3571	7.466e-117	385.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria	1224|Proteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_7,PAS_9,Response_reg
TH1_k127_7493326_0	686340.Metal_3572	3.458e-231	733.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T4BK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TH1_k127_7493326_3	765420.OSCT_1937	4.183e-50	182.0	COG0745@1|root,COG0745@2|Bacteria,2G9Q2@200795|Chloroflexi,377GJ@32061|Chloroflexia	32061|Chloroflexia	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TH1_k127_7493326_1	686340.Metal_3574	4.196e-122	406.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RX1K@1236|Gammaproteobacteria,1XGJU@135618|Methylococcales	135618|Methylococcales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
TH1_k127_7493326_5	697282.Mettu_3058	3.287e-23	99.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S7QZ@1236|Gammaproteobacteria,1XFEK@135618|Methylococcales	135618|Methylococcales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
TH1_k127_7591838_2	686340.Metal_0870	2.241e-52	188.0	COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,1RMCG@1236|Gammaproteobacteria,1XFH8@135618|Methylococcales	135618|Methylococcales	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	-	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1
TH1_k127_7591838_1	857087.Metme_2944	1.303e-71	249.0	COG2836@1|root,COG2836@2|Bacteria,1R9GA@1224|Proteobacteria,1THXJ@1236|Gammaproteobacteria,1XFZ7@135618|Methylococcales	135618|Methylococcales	S	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K09792	-	-	-	-	ko00000	-	-	-	DsbD_2
TH1_k127_7591838_0	857087.Metme_2945	1.123e-310	974.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1XE6F@135618|Methylococcales	135618|Methylococcales	P	P-type ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
TH1_k127_7591838_3	686340.Metal_0795	7.128e-49	185.0	2E75F@1|root,331PN@2|Bacteria,1N33G@1224|Proteobacteria,1SQ3F@1236|Gammaproteobacteria,1XFKV@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_7591838_4	857087.Metme_2947	6.745e-18	89.0	2EIVN@1|root,33CM0@2|Bacteria,1NP3M@1224|Proteobacteria,1SVDM@1236|Gammaproteobacteria,1XFTE@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_7591838_6	857087.Metme_2948	1.036e-15	78.0	2BKZK@1|root,32FGB@2|Bacteria,1Q0KS@1224|Proteobacteria,1THWE@1236|Gammaproteobacteria,1XFVS@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ATPase-cat_bd
TH1_k127_7591838_7	686340.Metal_0792	9.253e-11	65.0	2EKAZ@1|root,2ZI7M@2|Bacteria,1P6J4@1224|Proteobacteria,1SVHE@1236|Gammaproteobacteria,1XFVN@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_7591838_5	857087.Metme_2217	8.517e-16	81.0	COG0683@1|root,COG0683@2|Bacteria,1MWGW@1224|Proteobacteria,1RQ5G@1236|Gammaproteobacteria,1XDS8@135618|Methylococcales	135618|Methylococcales	E	TIGRFAM ABC transporter, substrate binding protein, PQQ-dependent alcohol dehydrogenase system	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
TH1_k127_7594748_4	857087.Metme_1516	7.025e-75	259.0	COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,1RMJW@1236|Gammaproteobacteria,1XDQU@135618|Methylococcales	135618|Methylococcales	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
TH1_k127_7594748_2	697282.Mettu_0415	7.947e-249	772.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,1XEBP@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TH1_k127_7594748_0	697282.Mettu_0414	0.0	1202.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,1XEQR@135618|Methylococcales	135618|Methylococcales	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
TH1_k127_7594748_1	697282.Mettu_0336	2.696e-270	844.0	COG1368@1|root,COG1368@2|Bacteria,1RG6W@1224|Proteobacteria,1RY34@1236|Gammaproteobacteria,1XFZX@135618|Methylococcales	135618|Methylococcales	M	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TH1_k127_7594748_6	933262.AXAM01000053_gene2703	4.897e-45	170.0	COG2995@1|root,COG2995@2|Bacteria,1N2QU@1224|Proteobacteria,43BAA@68525|delta/epsilon subdivisions,2X6PG@28221|Deltaproteobacteria,2MNJC@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Paraquat-inducible protein A	-	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
TH1_k127_7594748_5	384676.PSEEN4697	1.026e-61	218.0	COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,1RM9Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	paraquat-inducible protein A	yebS	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0071944	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
TH1_k127_7594748_3	1278309.KB907105_gene1464	4.461e-196	642.0	COG3008@1|root,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,1RN89@1236|Gammaproteobacteria,1XJ1N@135619|Oceanospirillales	135619|Oceanospirillales	Q	Paraquat-inducible protein B	-	-	-	-	-	-	-	-	-	-	-	-	MlaD
TH1_k127_7596108_4	102125.Xen7305DRAFT_00039580	3.885e-26	112.0	2E5SP@1|root,330H2@2|Bacteria,1GEVC@1117|Cyanobacteria	1117|Cyanobacteria	S	Glycine-zipper domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_7596108_0	1123242.JH636434_gene3212	0.0	1080.0	COG3119@1|root,COG3119@2|Bacteria,2IX0Y@203682|Planctomycetes	203682|Planctomycetes	P	PFAM sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
TH1_k127_7596108_3	247490.KSU1_C1440	1.019e-35	146.0	2DSS0@1|root,33H81@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3313)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3313
TH1_k127_7596108_1	909663.KI867149_gene3370	1.946e-152	503.0	COG1075@1|root,COG1075@2|Bacteria,1NYAK@1224|Proteobacteria,42Q3C@68525|delta/epsilon subdivisions,2WMAK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TH1_k127_7596108_2	1249627.D779_3579	3.246e-55	196.0	COG1974@1|root,COG1974@2|Bacteria,1MZFA@1224|Proteobacteria,1S5X5@1236|Gammaproteobacteria,1WYGY@135613|Chromatiales	135613|Chromatiales	KT	Belongs to the peptidase S24 family	-	-	-	ko:K03503	-	-	-	-	ko00000,ko01000,ko01002,ko03400	-	-	-	Peptidase_S24
TH1_k127_7608835_3	1123057.P872_15805	4.565e-11	68.0	COG2265@1|root,COG2265@2|Bacteria,4PPHS@976|Bacteroidetes,47RXE@768503|Cytophagia	976|Bacteroidetes	J	Vibrio cholerae RfbT protein	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
TH1_k127_7608835_4	1123258.AQXZ01000017_gene4239	0.0002197	47.0	COG2520@1|root,COG2520@2|Bacteria,2I388@201174|Actinobacteria	201174|Actinobacteria	J	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
TH1_k127_7608835_1	765912.Thimo_0332	1.356e-142	462.0	COG0463@1|root,COG2246@1|root,COG0463@2|Bacteria,COG2246@2|Bacteria,1MV8J@1224|Proteobacteria,1S1IR@1236|Gammaproteobacteria,1WW4E@135613|Chromatiales	135613|Chromatiales	M	glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,GtrA
TH1_k127_7608835_0	686340.Metal_1551	3.257e-149	485.0	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,1XE33@135618|Methylococcales	135618|Methylococcales	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
TH1_k127_7608835_2	105559.Nwat_2538	2.143e-35	148.0	COG0457@1|root,COG0457@2|Bacteria,1R50I@1224|Proteobacteria,1RSP6@1236|Gammaproteobacteria,1WY6N@135613|Chromatiales	135613|Chromatiales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_7626895_0	391600.ABRU01000039_gene1909	1.368e-126	428.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,2TT1Y@28211|Alphaproteobacteria,2KFQ5@204458|Caulobacterales	204458|Caulobacterales	D	PFAM lipopolysaccharide biosynthesis protein	-	-	-	ko:K16554	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	8.A.3.1	-	-	AAA_31,GNVR,Wzz
TH1_k127_7626895_2	269796.Rru_A1491	6.584e-08	62.0	2EAYM@1|root,334ZJ@2|Bacteria,1NE7J@1224|Proteobacteria,2UGV7@28211|Alphaproteobacteria,2JUAK@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_7626895_1	765913.ThidrDRAFT_2611	1.029e-30	125.0	COG0639@1|root,COG0639@2|Bacteria,1RD8M@1224|Proteobacteria	1224|Proteobacteria	T	COG0639 Diadenosine tetraphosphatase and related serine threonine protein phosphatases	prp1	-	3.1.3.16	ko:K07313	-	-	-	-	ko00000,ko01000	-	-	-	Metallophos
TH1_k127_7627297_2	1454004.AW11_00198	9.324e-19	87.0	COG0457@1|root,COG1413@1|root,COG0457@2|Bacteria,COG1413@2|Bacteria,1MX2U@1224|Proteobacteria,2WHVC@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Paired_CXXCH_1
TH1_k127_7627297_0	314278.NB231_01773	0.0	1158.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,1RPDE@1236|Gammaproteobacteria,1WWMT@135613|Chromatiales	135613|Chromatiales	P	PFAM Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TH1_k127_7627297_1	1283300.ATXB01000001_gene397	1.673e-107	355.0	COG3900@1|root,COG3900@2|Bacteria,1RKQP@1224|Proteobacteria,1SB83@1236|Gammaproteobacteria,1XGK1@135618|Methylococcales	135618|Methylococcales	S	Predicted periplasmic protein (DUF2092)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092
TH1_k127_7673404_2	1500890.JQNL01000001_gene469	9.218e-75	261.0	COG3746@1|root,COG3746@2|Bacteria,1R45W@1224|Proteobacteria,1RNG5@1236|Gammaproteobacteria,1X52K@135614|Xanthomonadales	135614|Xanthomonadales	P	Phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	Porin_O_P
TH1_k127_7673404_1	686340.Metal_3274	1.607e-161	514.0	COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,1RQDH@1236|Gammaproteobacteria,1XE8V@135618|Methylococcales	135618|Methylococcales	P	TIGRFAM phosphate binding protein	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
TH1_k127_7673404_0	697282.Mettu_2658	0.0	1394.0	COG0045@1|root,COG0454@1|root,COG1042@1|root,COG0045@2|Bacteria,COG0454@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria,1XDMM@135618|Methylococcales	135618|Methylococcales	C	CoA binding domain	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig
TH1_k127_767803_0	1116472.MGMO_60c00200	8.995e-257	800.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,1RMMD@1236|Gammaproteobacteria,1XE58@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TH1_k127_767803_1	857087.Metme_2792	2.913e-86	289.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1RN64@1236|Gammaproteobacteria,1XEK8@135618|Methylococcales	135618|Methylococcales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TH1_k127_767803_2	686340.Metal_3802	1.023e-09	64.0	COG3073@1|root,COG3073@2|Bacteria,1QICT@1224|Proteobacteria,1SJ3Y@1236|Gammaproteobacteria,1XFUY@135618|Methylococcales	135618|Methylococcales	T	Anti sigma-E protein RseA, N-terminal domain	-	-	-	ko:K03597	-	-	-	-	ko00000,ko03021	-	-	-	RseA_N
TH1_k127_7724405_3	697282.Mettu_1149	7.4e-134	432.0	COG0384@1|root,COG0384@2|Bacteria,1MUAS@1224|Proteobacteria,1RPWM@1236|Gammaproteobacteria,1XEX6@135618|Methylococcales	135618|Methylococcales	S	TIGRFAM phenazine biosynthesis	-	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
TH1_k127_7724405_0	1116472.MGMO_128c00120	0.0	1250.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,1RMWN@1236|Gammaproteobacteria,1XEE6@135618|Methylococcales	135618|Methylococcales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	ko:K00372	ko00910,ko01120,map00910,map01120	M00531	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
TH1_k127_7724405_1	1116472.MGMO_128c00130	1.068e-307	953.0	COG0437@1|root,COG3302@1|root,COG0437@2|Bacteria,COG3302@2|Bacteria,1MU1B@1224|Proteobacteria,1RNFG@1236|Gammaproteobacteria,1XFU7@135618|Methylococcales	135618|Methylococcales	C	4Fe-4S dicluster domain	-	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11,Form-deh_trans
TH1_k127_7724405_6	596153.Alide_4618	2.147e-33	131.0	COG1917@1|root,COG1917@2|Bacteria,1RFBG@1224|Proteobacteria,2VSVQ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM Cupin 2 conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TH1_k127_7724405_2	1116472.MGMO_92c00220	3.19e-141	454.0	COG3011@1|root,COG3011@2|Bacteria,1NP8B@1224|Proteobacteria,1RZ0C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF393,VKG_Carbox
TH1_k127_7724405_5	697282.Mettu_3489	6.72e-36	138.0	293CB@1|root,2ZQUX@2|Bacteria,1PBAC@1224|Proteobacteria,1SU7X@1236|Gammaproteobacteria,1XFU3@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_776243_1	1116472.MGMO_14c00130	5.864e-45	164.0	COG0642@1|root,COG2205@2|Bacteria,1MUZQ@1224|Proteobacteria,1RMZT@1236|Gammaproteobacteria,1XECF@135618|Methylococcales	135618|Methylococcales	T	Histidine kinase	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF_3,HATPase_c,HisKA,KdpD,Usp
TH1_k127_776243_2	1116472.MGMO_125c00020	2.477e-13	76.0	2AWIE@1|root,31NF0@2|Bacteria,1QK64@1224|Proteobacteria,1TI9B@1236|Gammaproteobacteria,1XGTE@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_776243_0	686340.Metal_0986	5e-323	998.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,1RPM6@1236|Gammaproteobacteria,1XEVW@135618|Methylococcales	135618|Methylococcales	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
TH1_k127_776243_3	93220.LV28_04760	4.652e-10	61.0	COG2156@1|root,COG2156@2|Bacteria,1RABG@1224|Proteobacteria,2VQ72@28216|Betaproteobacteria,1K3NK@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex	kdpC	-	3.6.3.12	ko:K01548	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpC
TH1_k127_7766808_3	697282.Mettu_4066	1.393e-19	89.0	COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,1RMAF@1236|Gammaproteobacteria,1XEMD@135618|Methylococcales	135618|Methylococcales	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	-	-	-	-	-	-	-	-	-	-	-	FGGY_C,FGGY_N
TH1_k127_7766808_2	666681.M301_0029	8.2e-109	362.0	COG1305@1|root,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,2VH3S@28216|Betaproteobacteria,2KKHH@206350|Nitrosomonadales	206350|Nitrosomonadales	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
TH1_k127_7766808_1	1116472.MGMO_21c00230	0.0	1077.0	COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,1RPDC@1236|Gammaproteobacteria,1XG1Q@135618|Methylococcales	135618|Methylococcales	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_2
TH1_k127_7766808_0	697282.Mettu_3446	0.0	1553.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,1RMX2@1236|Gammaproteobacteria,1XEK9@135618|Methylococcales	135618|Methylococcales	E	Bacterial transglutaminase-like N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
TH1_k127_7786165_3	1116472.MGMO_7c00370	2.708e-28	119.0	29V41@1|root,30GHG@2|Bacteria,1QJT6@1224|Proteobacteria,1THUE@1236|Gammaproteobacteria,1XFRB@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_7786165_5	1283300.ATXB01000001_gene1385	4.233e-16	82.0	2EHHF@1|root,33B9C@2|Bacteria,1NM2H@1224|Proteobacteria,1SECY@1236|Gammaproteobacteria,1XFWY@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_7786165_1	697282.Mettu_0671	5.844e-131	433.0	COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,1RMKI@1236|Gammaproteobacteria,1XES6@135618|Methylococcales	135618|Methylococcales	K	ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Rrf2,Virul_fac_BrkB
TH1_k127_7786165_6	1116472.MGMO_8c00110	4.524e-16	85.0	29SVM@1|root,30E1S@2|Bacteria,1QJS6@1224|Proteobacteria,1THTG@1236|Gammaproteobacteria,1XFNE@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_7786165_0	697282.Mettu_1839	0.0	1067.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1XEBD@135618|Methylococcales	135618|Methylococcales	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
TH1_k127_7786165_2	857087.Metme_2613	7.489e-70	241.0	2DKVG@1|root,30GRY@2|Bacteria,1RDQT@1224|Proteobacteria,1S80C@1236|Gammaproteobacteria,1XFEZ@135618|Methylococcales	135618|Methylococcales	S	Cytochrome P460	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_P460
TH1_k127_7786165_4	697282.Mettu_2516	3.352e-25	106.0	COG2954@1|root,COG2954@2|Bacteria,1RI38@1224|Proteobacteria,1S77V@1236|Gammaproteobacteria,1XF52@135618|Methylococcales	135618|Methylococcales	S	CYTH	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CYTH
TH1_k127_779110_8	697282.Mettu_3785	2.475e-43	160.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1S610@1236|Gammaproteobacteria,1XFCX@135618|Methylococcales	135618|Methylococcales	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate	tsaC	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
TH1_k127_779110_3	697282.Mettu_0034	3.978e-100	332.0	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,1RPBB@1236|Gammaproteobacteria,1XDVP@135618|Methylococcales	135618|Methylococcales	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
TH1_k127_779110_0	697282.Mettu_0033	2.211e-283	876.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,1XDJV@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
TH1_k127_779110_5	686340.Metal_2575	1.815e-87	297.0	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,1S2U7@1236|Gammaproteobacteria,1XF2F@135618|Methylococcales	135618|Methylococcales	L	Phage SPO1 DNA polymerase-related protein	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TH1_k127_779110_6	686340.Metal_2576	5.212e-70	241.0	COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,1S9G0@1236|Gammaproteobacteria,1XEY7@135618|Methylococcales	135618|Methylococcales	K	Ribosomal-protein-alanine acetyltransferase	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
TH1_k127_779110_1	686340.Metal_3220	9.144e-133	426.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,1RNME@1236|Gammaproteobacteria,1XDNW@135618|Methylococcales	135618|Methylococcales	G	Inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
TH1_k127_779110_4	697282.Mettu_0029	1.115e-95	319.0	COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,1RPD3@1236|Gammaproteobacteria,1XEFC@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	trmJ	-	2.1.1.200	ko:K15396	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
TH1_k127_779110_2	686340.Metal_3222	6.238e-131	421.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,1RNCA@1236|Gammaproteobacteria,1XDPS@135618|Methylococcales	135618|Methylococcales	E	TIGRFAM Serine O-acetyltransferase	-	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
TH1_k127_779110_7	697282.Mettu_0027	7.186e-49	176.0	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,1S3RW@1236|Gammaproteobacteria,1XF1K@135618|Methylococcales	135618|Methylococcales	K	Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins	-	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
TH1_k127_780243_0	857087.Metme_3258	1.522e-264	823.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008964,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0072350	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	iSFV_1184.SFV_4025	PEPcase
TH1_k127_7818454_2	261292.Nit79A3_2358	5.578e-154	491.0	COG0451@1|root,COG0451@2|Bacteria,1MU1A@1224|Proteobacteria,2VK3S@28216|Betaproteobacteria	28216|Betaproteobacteria	GM	Nad-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TH1_k127_7818454_0	697282.Mettu_4177	4.863e-195	614.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1XEWY@135618|Methylococcales	135618|Methylococcales	H	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
TH1_k127_7818454_7	1496688.ER33_06230	1.714e-32	130.0	COG3453@1|root,COG3453@2|Bacteria,1G6UU@1117|Cyanobacteria	1117|Cyanobacteria	S	phosphatase (DUF442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF442
TH1_k127_7818454_3	1000565.METUNv1_03199	7.187e-88	293.0	COG2032@1|root,COG2032@2|Bacteria,1RGV4@1224|Proteobacteria,2WFV1@28216|Betaproteobacteria,2KXHE@206389|Rhodocyclales	206389|Rhodocyclales	P	Superoxide dismutase	-	-	1.15.1.1	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Cu
TH1_k127_7818454_4	266835.14024661	1.793e-83	287.0	COG3369@1|root,COG3592@1|root,COG3369@2|Bacteria,COG3592@2|Bacteria,1RCN9@1224|Proteobacteria,2U878@28211|Alphaproteobacteria,43MTM@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	CDGSH-type zinc finger. Function unknown.	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_19,Ferritin-like,zf-CDGSH
TH1_k127_7818454_1	697282.Mettu_4339	7.873e-195	615.0	COG0738@1|root,COG0738@2|Bacteria,1MXDC@1224|Proteobacteria,1RQX9@1236|Gammaproteobacteria,1XDYZ@135618|Methylococcales	135618|Methylococcales	G	Major Facilitator Superfamily	-	-	-	ko:K02429	-	-	-	-	ko00000,ko02000	2.A.1.7	-	-	MFS_1
TH1_k127_7818454_6	1304885.AUEY01000159_gene3709	2.881e-33	130.0	29YCG@1|root,30K6V@2|Bacteria,1QMIS@1224|Proteobacteria,4368I@68525|delta/epsilon subdivisions,2X0SW@28221|Deltaproteobacteria,2MPCX@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
TH1_k127_7818454_5	1304885.AUEY01000159_gene3708	8.355e-49	174.0	2E3EN@1|root,32YDN@2|Bacteria,1N7N7@1224|Proteobacteria,42VC8@68525|delta/epsilon subdivisions,2WS7K@28221|Deltaproteobacteria,2MM1P@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4160)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4160
TH1_k127_7818454_8	1116472.MGMO_178c00040	1.099e-25	107.0	2E3RR@1|root,32YPD@2|Bacteria,1P2VF@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_7835812_0	686340.Metal_1802	1.258e-185	582.0	COG0175@1|root,COG0175@2|Bacteria,1MUCZ@1224|Proteobacteria,1RNAD@1236|Gammaproteobacteria,1XECQ@135618|Methylococcales	135618|Methylococcales	H	Sulfate adenylyltransferase subunit 2	cysD	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004779,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0070566,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
TH1_k127_7835812_1	1122599.AUGR01000013_gene760	6.274e-178	563.0	COG2895@1|root,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,1RME4@1236|Gammaproteobacteria,1XH42@135619|Oceanospirillales	135619|Oceanospirillales	P	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	cysN	-	2.7.1.25,2.7.7.4	ko:K00955,ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU,GTP_EFTU_D3
TH1_k127_7852837_3	1116472.MGMO_53c01030	1.217e-07	55.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RN70@1236|Gammaproteobacteria,1XDT5@135618|Methylococcales	135618|Methylococcales	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
TH1_k127_7852837_0	1116472.MGMO_71c00010	1.932e-89	306.0	COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,1R9SN@1224|Proteobacteria,1S967@1236|Gammaproteobacteria,1XFK2@135618|Methylococcales	135618|Methylococcales	K	helix_turn_helix, mercury resistance	-	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding,B12-binding_2,MerR_1
TH1_k127_7852837_2	1283300.ATXB01000001_gene1210	3.776e-12	72.0	2AW6E@1|root,31N1F@2|Bacteria,1QJT8@1224|Proteobacteria,1THUH@1236|Gammaproteobacteria,1XFRN@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_7852837_1	395493.BegalDRAFT_0276	7.301e-34	133.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,45ZVM@72273|Thiotrichales	72273|Thiotrichales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
TH1_k127_7853242_0	697282.Mettu_0269	8.82e-194	613.0	COG1488@1|root,COG1488@2|Bacteria,1QJI0@1224|Proteobacteria,1THHZ@1236|Gammaproteobacteria,1XE4J@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
TH1_k127_7853242_1	697282.Mettu_0268	2.202e-70	243.0	COG1335@1|root,COG1335@2|Bacteria,1MUGW@1224|Proteobacteria,1RZBF@1236|Gammaproteobacteria,1XF7J@135618|Methylococcales	135618|Methylococcales	Q	Isochorismatase family	-	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
TH1_k127_7853242_2	1123392.AQWL01000001_gene1445	3.149e-12	67.0	COG2863@1|root,COG2863@2|Bacteria,1N7W9@1224|Proteobacteria,2VUTK@28216|Betaproteobacteria,1KTD5@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
TH1_k127_788102_3	765914.ThisiDRAFT_0619	1.422e-07	54.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1,Y2_Tnp
TH1_k127_788102_1	686340.Metal_3874	3.745e-233	734.0	COG4178@1|root,COG4178@2|Bacteria,1MW09@1224|Proteobacteria,1RPQA@1236|Gammaproteobacteria,1XEC2@135618|Methylococcales	135618|Methylococcales	S	ABC transporter	-	-	-	ko:K02471	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.203.11,3.A.1.203.4	-	-	ABC_membrane_2
TH1_k127_788102_0	663610.JQKO01000004_gene2745	2.001e-264	822.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,3NC0H@45404|Beijerinckiaceae	28211|Alphaproteobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
TH1_k127_788102_2	696281.Desru_0980	2.98e-60	216.0	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,2606T@186807|Peptococcaceae	186801|Clostridia	P	pyridine nucleotide-disulphide oxidoreductase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2,Pyr_redox_dim,Rhodanese
TH1_k127_7895531_3	243233.MCA0552	5.657e-14	79.0	2F1EJ@1|root,33UF9@2|Bacteria,1NV3G@1224|Proteobacteria,1TI1Z@1236|Gammaproteobacteria,1XGBM@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_7895531_2	243233.MCA0552	6.045e-20	94.0	2F1EJ@1|root,33UF9@2|Bacteria,1NV3G@1224|Proteobacteria,1TI1Z@1236|Gammaproteobacteria,1XGBM@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_7895531_0	857087.Metme_0387	3.197e-136	439.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,1RN44@1236|Gammaproteobacteria,1XEIH@135618|Methylococcales	135618|Methylococcales	H	Belongs to the ribF family	-	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
TH1_k127_7895531_1	697282.Mettu_1553	1.121e-121	392.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1XDWG@135618|Methylococcales	135618|Methylococcales	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
TH1_k127_7916480_0	697282.Mettu_0901	2.356e-142	460.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,1RN2M@1236|Gammaproteobacteria,1XEHV@135618|Methylococcales	135618|Methylococcales	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
TH1_k127_7916480_1	1116472.MGMO_126c00290	2.001e-68	235.0	COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,1S3P9@1236|Gammaproteobacteria,1XF1Z@135618|Methylococcales	135618|Methylococcales	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
TH1_k127_7916480_2	857087.Metme_0616	1.161e-60	217.0	COG0235@1|root,COG0235@2|Bacteria,1N2XS@1224|Proteobacteria,1S573@1236|Gammaproteobacteria,1XFBZ@135618|Methylococcales	135618|Methylococcales	G	PFAM Class II aldolase	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
TH1_k127_7932708_0	697282.Mettu_1092	5.071e-289	908.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1XE8U@135618|Methylococcales	135618|Methylococcales	M	Penicillin-binding protein 1A	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
TH1_k127_7932708_1	697282.Mettu_1090	3.946e-105	344.0	COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,1RN8S@1236|Gammaproteobacteria,1XDJ8@135618|Methylococcales	135618|Methylococcales	NU	TIGRFAM type IV pilus assembly protein PilM	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
TH1_k127_7956919_0	697282.Mettu_3841	3.482e-229	718.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MWDY@1224|Proteobacteria,1RRXF@1236|Gammaproteobacteria,1XEIC@135618|Methylococcales	135618|Methylococcales	IQ	Phosphate acyltransferases	-	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding,Acyltransferase
TH1_k127_7980574_2	443143.GM18_0462	8.974e-33	134.0	COG4585@1|root,COG4585@2|Bacteria,1RKV1@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TH1_k127_7980574_1	697282.Mettu_2727	5.82e-129	425.0	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,1RN14@1236|Gammaproteobacteria,1XEMV@135618|Methylococcales	135618|Methylococcales	J	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
TH1_k127_7980574_0	686340.Metal_1420	1.117e-171	544.0	COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,1RNN8@1236|Gammaproteobacteria,1XE5H@135618|Methylococcales	135618|Methylococcales	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
TH1_k127_7980574_3	1116472.MGMO_41c00180	3.286e-18	84.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,1RPBY@1236|Gammaproteobacteria,1XDQP@135618|Methylococcales	135618|Methylococcales	L	ATPase, AAA	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
TH1_k127_8014502_5	1116472.MGMO_2c00070	2.525e-39	152.0	COG4942@1|root,COG4942@2|Bacteria,1R1HI@1224|Proteobacteria,1T53G@1236|Gammaproteobacteria,1XH1F@135618|Methylococcales	135618|Methylococcales	D	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_8014502_1	697282.Mettu_2295	9.975e-105	346.0	COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,1S2BC@1236|Gammaproteobacteria,1XEBU@135618|Methylococcales	135618|Methylococcales	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TH1_k127_8014502_4	1116472.MGMO_88c00140	5.944e-47	172.0	COG1310@1|root,COG1310@2|Bacteria,1RJSM@1224|Proteobacteria,1S86M@1236|Gammaproteobacteria,1XFDW@135618|Methylococcales	135618|Methylococcales	S	Mov34 MPN PAD-1	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
TH1_k127_8014502_2	1116472.MGMO_88c00130	8.027e-97	325.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,1RNGK@1236|Gammaproteobacteria,1XE4V@135618|Methylococcales	135618|Methylococcales	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
TH1_k127_8014502_0	697282.Mettu_3518	2.914e-279	864.0	COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,1RMMN@1236|Gammaproteobacteria,1XEIF@135618|Methylococcales	135618|Methylococcales	M	PFAM Bacterial sugar transferase	-	-	-	ko:K03606	ko05111,map05111	-	-	-	ko00000,ko00001	-	-	-	Bac_transf,CoA_binding_3
TH1_k127_8014502_3	697282.Mettu_3517	1.533e-64	223.0	COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,1RQSM@1236|Gammaproteobacteria,1XEU3@135618|Methylococcales	135618|Methylococcales	M	polysaccharide export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
TH1_k127_8024846_1	857087.Metme_1877	1.009e-154	494.0	COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,1RMKU@1236|Gammaproteobacteria,1XDMK@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
TH1_k127_8024846_0	686340.Metal_0447	8.878e-255	793.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1XDSN@135618|Methylococcales	135618|Methylococcales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
TH1_k127_8051312_1	686340.Metal_3559	4.346e-100	332.0	COG0546@1|root,COG0546@2|Bacteria,1RHA9@1224|Proteobacteria,1SHRV@1236|Gammaproteobacteria,1XEYY@135618|Methylococcales	135618|Methylococcales	S	phosphoglycolate phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_8051312_3	857087.Metme_1765	1.152e-48	176.0	COG0375@1|root,COG0375@2|Bacteria,1MZJH@1224|Proteobacteria,1S5WG@1236|Gammaproteobacteria,1XFP3@135618|Methylococcales	135618|Methylococcales	C	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
TH1_k127_8051312_0	857087.Metme_1764	2.894e-132	435.0	COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,1RN9Y@1236|Gammaproteobacteria,1XEEW@135618|Methylococcales	135618|Methylococcales	KO	Hydrogenase accessory protein HypB	-	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
TH1_k127_8051312_4	857087.Metme_1760	3.174e-29	118.0	COG0298@1|root,COG0298@2|Bacteria,1N76Y@1224|Proteobacteria,1SCGX@1236|Gammaproteobacteria,1XFXJ@135618|Methylococcales	135618|Methylococcales	O	TIGRFAM Hydrogenase expression formation protein, HupF HypC	-	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
TH1_k127_8051312_2	697282.Mettu_4124	2.1e-65	225.0	COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,1RRTQ@1236|Gammaproteobacteria,1XETX@135618|Methylococcales	135618|Methylococcales	O	Belongs to the HypD family	-	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
TH1_k127_8053566_2	686340.Metal_1170	5.432e-19	90.0	COG0845@1|root,COG0845@2|Bacteria,1MXGH@1224|Proteobacteria,1SYRU@1236|Gammaproteobacteria,1XDWY@135618|Methylococcales	135618|Methylococcales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
TH1_k127_8053566_0	686340.Metal_1171	1.848e-157	510.0	COG1538@1|root,COG1538@2|Bacteria,1R8XP@1224|Proteobacteria,1SZE3@1236|Gammaproteobacteria,1XEJN@135618|Methylococcales	135618|Methylococcales	MU	PFAM Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TH1_k127_8053566_1	857087.Metme_4024	5.814e-76	272.0	COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,1RMM5@1236|Gammaproteobacteria,1XEBN@135618|Methylococcales	135618|Methylococcales	NU	COG3170 Tfp pilus assembly protein FimV	-	-	-	ko:K08086	-	-	-	-	ko00000	-	-	-	-
TH1_k127_8068284_1	243233.MCA0139	1.548e-94	311.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,1RNV6@1236|Gammaproteobacteria,1XEHS@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
TH1_k127_8068284_0	1283300.ATXB01000001_gene575	2.05e-238	751.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1XDJI@135618|Methylococcales	135618|Methylococcales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TH1_k127_8068284_2	697282.Mettu_1617	2.309e-37	149.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1XDWX@135618|Methylococcales	135618|Methylococcales	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
TH1_k127_8078765_2	1144343.PMI41_02904	1.263e-16	86.0	COG2273@1|root,COG2273@2|Bacteria,1Q6IY@1224|Proteobacteria,2TVH1@28211|Alphaproteobacteria,43IPQ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Hydrolase Family 16	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_8078765_1	794903.OPIT5_11460	3.179e-22	112.0	COG3664@1|root,COG3664@2|Bacteria,46Y3P@74201|Verrucomicrobia,3K8VS@414999|Opitutae	414999|Opitutae	G	PFAM glycoside hydrolase family 39	-	-	-	ko:K21000	ko02025,map02025	-	-	-	ko00000,ko00001	-	GH39	-	-
TH1_k127_8078765_0	697282.Mettu_3516	9.285e-64	220.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,1RNB0@1236|Gammaproteobacteria,1XDRW@135618|Methylococcales	135618|Methylococcales	D	G-rich domain on putative tyrosine kinase	-	-	-	ko:K16554,ko:K16692	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02000	8.A.3.1	-	-	AAA_31,GNVR,Wzz
TH1_k127_8082439_2	880072.Desac_2384	1.883e-118	392.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42Q4P@68525|delta/epsilon subdivisions,2WJHQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
TH1_k127_8082439_0	243233.MCA0120	2.014e-150	484.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,1RNN1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TH1_k127_8082439_3	1123059.KB823011_gene909	3.327e-74	265.0	COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,2TQME@28211|Alphaproteobacteria,43XB5@69657|Hyphomonadaceae	28211|Alphaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger
TH1_k127_8082439_1	1041139.KB902624_gene5814	6.505e-138	446.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,2TT0G@28211|Alphaproteobacteria,4B93F@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Sulfate permease and related transporters (MFS superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
TH1_k127_8109930_0	697282.Mettu_4324	6.83e-238	739.0	COG0446@1|root,COG0446@2|Bacteria,1QUQF@1224|Proteobacteria,1RP1H@1236|Gammaproteobacteria,1XEFP@135618|Methylococcales	135618|Methylococcales	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TH1_k127_8109930_5	857087.Metme_3953	2.911e-28	114.0	COG0607@1|root,30JW6@2|Bacteria,1PGPU@1224|Proteobacteria,1RUXS@1236|Gammaproteobacteria,1XGR5@135618|Methylococcales	135618|Methylococcales	P	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
TH1_k127_8109930_2	697282.Mettu_1687	1.452e-149	478.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,1XDSQ@135618|Methylococcales	135618|Methylococcales	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
TH1_k127_8109930_3	1116472.MGMO_125c00260	9.652e-110	363.0	COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,1RP0P@1236|Gammaproteobacteria,1XEK0@135618|Methylococcales	135618|Methylococcales	O	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host	djlA	-	-	ko:K05801	-	-	-	-	ko00000,ko03110	-	-	-	DnaJ,TerB
TH1_k127_8109930_1	1116472.MGMO_61c00370	4.764e-214	676.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1XE8Y@135618|Methylococcales	135618|Methylococcales	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
TH1_k127_8109930_6	1042375.AFPL01000038_gene1619	9.225e-09	57.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,464D8@72275|Alteromonadaceae	1236|Gammaproteobacteria	NU	COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	xpsE	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
TH1_k127_8109930_4	1283300.ATXB01000001_gene1945	2.323e-39	152.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,1XEBQ@135618|Methylococcales	135618|Methylococcales	U	type II secretion system	-	-	-	ko:K02455	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSF
TH1_k127_8111992_0	686340.Metal_3791	0.0	1042.0	COG1061@1|root,COG1061@2|Bacteria,1MXFH@1224|Proteobacteria,1RP46@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KL	Type III	-	-	3.1.21.5	ko:K01156	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	ResIII
TH1_k127_8111992_4	1286631.X805_01900	3.436e-23	104.0	COG1061@1|root,COG1061@2|Bacteria,1MXFH@1224|Proteobacteria,2WGXI@28216|Betaproteobacteria	28216|Betaproteobacteria	KL	Type III restriction enzyme, res subunit	-	-	3.1.21.5	ko:K01156	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	ResIII
TH1_k127_8111992_5	547045.NEISICOT_01385	3.854e-16	85.0	2BKHD@1|root,2ZGSD@2|Bacteria,1P4ZX@1224|Proteobacteria,2W55F@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_8111992_3	1504672.669784058	1.522e-24	103.0	COG3093@1|root,COG3093@2|Bacteria,1N76J@1224|Proteobacteria,2VUG3@28216|Betaproteobacteria,4AF86@80864|Comamonadaceae	28216|Betaproteobacteria	K	Plasmid maintenance system antidote protein	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
TH1_k127_8111992_1	1504672.669784057	1.238e-63	221.0	COG2189@1|root,COG2189@2|Bacteria,1MX9M@1224|Proteobacteria,2VGZB@28216|Betaproteobacteria,4ACHT@80864|Comamonadaceae	28216|Betaproteobacteria	L	DNA methylase N-4 N-6	-	-	2.1.1.72	ko:K00571,ko:K07316	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
TH1_k127_8111992_2	686340.Metal_3790	1.604e-51	184.0	COG2189@1|root,COG2189@2|Bacteria,1MX9M@1224|Proteobacteria,1RNHM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Adenine specific DNA methylase Mod	-	-	2.1.1.72	ko:K00571,ko:K07316,ko:K07319	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase,TypeIII_RM_meth
TH1_k127_8113250_5	522306.CAP2UW1_3223	5.763e-19	89.0	COG4913@1|root,COG4913@2|Bacteria,1N16Z@1224|Proteobacteria,2VJD2@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Putative exonuclease SbcCD, C subunit	-	-	-	-	-	-	-	-	-	-	-	-	AAA_29,SbcCD_C
TH1_k127_8113250_1	522306.CAP2UW1_3224	1.125e-88	298.0	2CB46@1|root,31GHU@2|Bacteria,1NGIC@1224|Proteobacteria,2VQSQ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Domain of unknown function (DUF4194)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4194
TH1_k127_8113250_0	1454004.AW11_01864	7.84e-251	780.0	COG4942@1|root,COG4942@2|Bacteria,1MXRZ@1224|Proteobacteria,2VN9G@28216|Betaproteobacteria	28216|Betaproteobacteria	D	Protein of unknown function (DUF3375)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3375
TH1_k127_8113250_6	1283300.ATXB01000001_gene400	3.922e-05	47.0	COG3548@1|root,COG3548@2|Bacteria	2|Bacteria	S	protein homotetramerization	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
TH1_k127_8113250_3	765913.ThidrDRAFT_0914	2.48e-46	183.0	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,1RZEA@1236|Gammaproteobacteria,1WWTV@135613|Chromatiales	135613|Chromatiales	O	TIGRFAM Cytochrome c-type biogenesis protein CcmI	-	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_2
TH1_k127_8113250_4	911239.CF149_22123	2.482e-39	159.0	COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,1S9DV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	subunit of a heme lyase	ccmH	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015035,GO:0015036,GO:0016020,GO:0016043,GO:0016491,GO:0016667,GO:0017004,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0055114,GO:0065003,GO:0071840,GO:0071944,GO:0098552,GO:0098567	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
TH1_k127_8113250_2	1265503.KB905161_gene3053	7.895e-53	190.0	COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,1S5YV@1236|Gammaproteobacteria,2Q6R4@267889|Colwelliaceae	1236|Gammaproteobacteria	CO	Redoxin	ccmG	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
TH1_k127_8120378_1	1116472.MGMO_93c00300	4.223e-88	295.0	COG2135@1|root,COG2135@2|Bacteria,1RER4@1224|Proteobacteria,1S3AX@1236|Gammaproteobacteria,1XGZZ@135618|Methylococcales	135618|Methylococcales	S	SOS response associated peptidase (SRAP)	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
TH1_k127_8120378_2	1183438.GKIL_3793	5.513e-07	51.0	COG1974@1|root,COG1974@2|Bacteria,1G6T1@1117|Cyanobacteria	1117|Cyanobacteria	KT	Belongs to the peptidase S24 family	umuD	-	-	ko:K03503	-	-	-	-	ko00000,ko01000,ko01002,ko03400	-	-	-	Peptidase_S24
TH1_k127_8120378_0	686340.Metal_4032	8.998e-129	413.0	COG1988@1|root,COG1988@2|Bacteria,1Q0WR@1224|Proteobacteria,1RU1K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	membrane-bound metal-dependent	ydjM	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0031668,GO:0033554,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:0071944	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
TH1_k127_8146921_0	494416.AYXN01000042_gene1768	0.0	1040.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,3NJUH@468|Moraxellaceae	1236|Gammaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
TH1_k127_8156457_2	765911.Thivi_3276	5.217e-159	504.0	COG0297@1|root,COG4223@1|root,COG0297@2|Bacteria,COG4223@2|Bacteria,1P7F2@1224|Proteobacteria,1RZVJ@1236|Gammaproteobacteria,1WX4C@135613|Chromatiales	135613|Chromatiales	F	Synthesizes alpha-1,4-glucan chains using ADP-glucose	-	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
TH1_k127_8156457_1	1283300.ATXB01000001_gene664	2.513e-177	565.0	COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,1RYKS@1236|Gammaproteobacteria,1XFWC@135618|Methylococcales	135618|Methylococcales	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	hDGE_amylase
TH1_k127_8156457_0	686340.Metal_3567	3.002e-217	682.0	COG0129@1|root,COG0129@2|Bacteria,1MU3T@1224|Proteobacteria,1RMNA@1236|Gammaproteobacteria,1XDP6@135618|Methylococcales	135618|Methylococcales	EG	Belongs to the IlvD Edd family	edd	-	4.2.1.12	ko:K01690	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00008	R02036	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
TH1_k127_8173779_1	686340.Metal_2510	7.458e-60	210.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1XEJP@135618|Methylococcales	135618|Methylococcales	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
TH1_k127_8173779_0	697282.Mettu_2522	4.942e-152	487.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1XES3@135618|Methylococcales	135618|Methylococcales	NU	type IV, pilus assembly	pilB	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
TH1_k127_81802_5	686340.Metal_1087	2.679e-141	450.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1XENG@135618|Methylococcales	135618|Methylococcales	H	Thiamine pyrophosphate enzyme, N-terminal TPP binding	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TH1_k127_81802_10	697282.Mettu_2398	5.975e-78	264.0	COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,1S20I@1236|Gammaproteobacteria,1XF0P@135618|Methylococcales	135618|Methylococcales	E	Acetolactate synthase, small subunit	-	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_5,ALS_ss_C
TH1_k127_81802_3	243233.MCA2272	1.882e-185	584.0	COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,1RNA8@1236|Gammaproteobacteria,1XE7R@135618|Methylococcales	135618|Methylococcales	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
TH1_k127_81802_0	697282.Mettu_3784	0.0	1265.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1XDRF@135618|Methylococcales	135618|Methylococcales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
TH1_k127_81802_11	697282.Mettu_3783	1.332e-59	212.0	COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,1S43X@1236|Gammaproteobacteria,1XF3H@135618|Methylococcales	135618|Methylococcales	S	Belongs to the Smg family	smg	-	-	ko:K03747	-	-	-	-	ko00000	-	-	-	DUF494
TH1_k127_81802_6	697282.Mettu_3782	3.901e-141	459.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria,1XE4B@135618|Methylococcales	135618|Methylococcales	L	PFAM DNA recombination-mediator protein A	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
TH1_k127_81802_7	857087.Metme_4268	3.72e-131	427.0	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1XE9I@135618|Methylococcales	135618|Methylococcales	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
TH1_k127_81802_9	686340.Metal_0275	1.241e-79	269.0	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria,1XF14@135618|Methylococcales	135618|Methylococcales	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	-	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
TH1_k127_81802_8	697282.Mettu_3770	5.346e-127	414.0	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,1RP1T@1236|Gammaproteobacteria,1XEPT@135618|Methylococcales	135618|Methylococcales	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
TH1_k127_81802_4	686340.Metal_0277	1.57e-163	524.0	COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,1XE0K@135618|Methylococcales	135618|Methylococcales	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
TH1_k127_81802_1	697282.Mettu_3767	4.24e-313	973.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1XEIM@135618|Methylococcales	135618|Methylococcales	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
TH1_k127_81802_2	697282.Mettu_3766	2.629e-221	692.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria,1XDQM@135618|Methylococcales	135618|Methylococcales	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH1_k127_81802_13	1129794.C427_4693	1.342e-20	93.0	COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,1RQYI@1236|Gammaproteobacteria,469JR@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
TH1_k127_81802_12	398579.Spea_3295	4.274e-31	123.0	COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,1RQYI@1236|Gammaproteobacteria,2Q9MA@267890|Shewanellaceae	1236|Gammaproteobacteria	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
TH1_k127_8182398_1	686340.Metal_0869	2.86e-51	190.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,1XEJC@135618|Methylococcales	135618|Methylococcales	M	Transfers the fatty acyl group on membrane lipoproteins	-	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
TH1_k127_8182398_0	261292.Nit79A3_1075	2.747e-79	271.0	COG3385@1|root,COG3385@2|Bacteria,1R807@1224|Proteobacteria,2W0D8@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
TH1_k127_8219538_0	697282.Mettu_0978	1.304e-314	967.0	COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,1RMFT@1236|Gammaproteobacteria,1XDYW@135618|Methylococcales	135618|Methylococcales	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
TH1_k127_8221042_3	857087.Metme_0604	7.926e-16	79.0	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,1S41P@1236|Gammaproteobacteria,1XEHW@135618|Methylococcales	135618|Methylococcales	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
TH1_k127_8221042_1	686340.Metal_0993	3.379e-53	196.0	COG0457@1|root,COG0457@2|Bacteria,1NPG5@1224|Proteobacteria,1SIX1@1236|Gammaproteobacteria,1XF77@135618|Methylococcales	135618|Methylococcales	S	Plant specific mitochondrial import receptor subunit TOM20	-	-	-	-	-	-	-	-	-	-	-	-	TOM20_plant
TH1_k127_8221042_0	1116472.MGMO_21c00240	1.389e-235	733.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,1XEIR@135618|Methylococcales	135618|Methylococcales	H	Belongs to the citrate synthase family	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
TH1_k127_8221042_2	697282.Mettu_3872	1.36e-38	146.0	COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,1S8VH@1236|Gammaproteobacteria,1XFIC@135618|Methylococcales	135618|Methylococcales	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hupB	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
TH1_k127_8249194_3	686340.Metal_3657	1.813e-26	111.0	COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,1S27C@1236|Gammaproteobacteria,1XF0E@135618|Methylococcales	135618|Methylococcales	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
TH1_k127_8249194_1	686340.Metal_3658	6.745e-122	396.0	COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,1RNTB@1236|Gammaproteobacteria,1XEH9@135618|Methylococcales	135618|Methylococcales	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
TH1_k127_8249194_4	697282.Mettu_4344	1.744e-05	53.0	2AW8R@1|root,31N40@2|Bacteria,1QJVG@1224|Proteobacteria,1THX3@1236|Gammaproteobacteria,1XFXI@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF4124)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124
TH1_k127_8249194_0	857087.Metme_4126	3.467e-140	450.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,1RNHC@1236|Gammaproteobacteria,1XDMX@135618|Methylococcales	135618|Methylococcales	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	cyoE	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
TH1_k127_8249194_2	686340.Metal_3870	8.014e-27	113.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,1XEP5@135618|Methylococcales	135618|Methylococcales	S	Belongs to the peptidase M16 family	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
TH1_k127_8261095_1	857087.Metme_3141	1.584e-49	183.0	COG3009@1|root,COG3009@2|Bacteria,1N8BW@1224|Proteobacteria,1SHZZ@1236|Gammaproteobacteria,1XF9Y@135618|Methylococcales	135618|Methylococcales	S	ABC-type transport auxiliary lipoprotein component	-	-	-	ko:K09857	-	-	-	-	ko00000	-	-	-	ABC_trans_aux
TH1_k127_8261095_0	857087.Metme_3142	4.171e-100	335.0	COG1463@1|root,COG1463@2|Bacteria,1Q6ZU@1224|Proteobacteria,1S6SW@1236|Gammaproteobacteria,1XGZV@135618|Methylococcales	135618|Methylococcales	Q	MlaD protein	-	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
TH1_k127_8276530_3	686340.Metal_1900	3.833e-29	118.0	COG0500@1|root,COG2226@2|Bacteria,1RDI3@1224|Proteobacteria,1S423@1236|Gammaproteobacteria,1XFA5@135618|Methylococcales	135618|Methylococcales	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25
TH1_k127_8276530_0	697282.Mettu_0637	0.0	1080.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,1RNRX@1236|Gammaproteobacteria,1XEEE@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
TH1_k127_8276530_5	1197906.CAJQ02000003_gene3219	8.287e-09	57.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,3JUGV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Resolvase	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TH1_k127_8276530_2	398579.Spea_3295	1.852e-29	119.0	COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,1RQYI@1236|Gammaproteobacteria,2Q9MA@267890|Shewanellaceae	1236|Gammaproteobacteria	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
TH1_k127_8276530_1	977880.pRALTA_0046	2.786e-149	492.0	28IHG@1|root,2Z8IP@2|Bacteria,1R4RG@1224|Proteobacteria,2VVIT@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_8276530_4	103690.17133839	4.153e-10	63.0	28IHG@1|root,2Z8IP@2|Bacteria,1G4GY@1117|Cyanobacteria,1HRM6@1161|Nostocales	1117|Cyanobacteria	S	SPTR Alr4702 protein	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C_3
TH1_k127_8280328_2	243233.MCA1012	9.496e-87	295.0	COG3000@1|root,COG3000@2|Bacteria,1NR7X@1224|Proteobacteria,1RQDX@1236|Gammaproteobacteria,1XECS@135618|Methylococcales	135618|Methylococcales	I	Fatty acid hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2934,FA_hydroxylase
TH1_k127_8280328_0	686340.Metal_2871	2.334e-134	437.0	COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,1RN39@1236|Gammaproteobacteria,1XES2@135618|Methylococcales	135618|Methylococcales	S	PFAM alpha beta hydrolase	-	-	-	ko:K07019	-	-	-	-	ko00000	-	-	-	Abhydrolase_1
TH1_k127_8280328_1	243233.MCA2020	5.976e-88	293.0	COG1225@1|root,COG1225@2|Bacteria,1R9YF@1224|Proteobacteria,1S37E@1236|Gammaproteobacteria,1XEZK@135618|Methylococcales	135618|Methylococcales	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TH1_k127_8347710_4	1116472.MGMO_105c00250	1.39e-36	157.0	2C2C7@1|root,31ND2@2|Bacteria,1QK45@1224|Proteobacteria,1TI70@1236|Gammaproteobacteria,1XGNH@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_8347710_3	686340.Metal_1386	8.491e-101	334.0	COG5501@1|root,COG5501@2|Bacteria,1PB0I@1224|Proteobacteria,1S435@1236|Gammaproteobacteria,1XDZ1@135618|Methylococcales	135618|Methylococcales	S	PFAM Sulphur oxidation protein SoxZ	-	-	-	ko:K17226	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxY,SoxZ
TH1_k127_8347710_1	1116472.MGMO_98c00010	1.805e-127	413.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,1S0BJ@1236|Gammaproteobacteria,1XEGD@135618|Methylococcales	135618|Methylococcales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TH1_k127_8347710_5	876269.ARWA01000001_gene2414	0.0005938	46.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2TRMU@28211|Alphaproteobacteria,3NA2W@45404|Beijerinckiaceae	28211|Alphaproteobacteria	NU	Type II secretion system (T2SS), protein E, N-terminal domain	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
TH1_k127_8347710_2	697282.Mettu_1128	7.505e-124	402.0	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,1RNJR@1236|Gammaproteobacteria,1XEBB@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
TH1_k127_8347710_0	697282.Mettu_3861	9.827e-178	561.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1XEMS@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
TH1_k127_8355916_2	765910.MARPU_16205	6.569e-49	190.0	COG3264@1|root,COG3264@2|Bacteria,1QWCW@1224|Proteobacteria,1T3T8@1236|Gammaproteobacteria,1X2V1@135613|Chromatiales	135613|Chromatiales	M	Mechanosensitive ion channel	-	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
TH1_k127_8355916_4	237368.SCABRO_02413	4.15e-13	70.0	29MQ2@1|root,308MT@2|Bacteria,2J179@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_8355916_1	1283300.ATXB01000001_gene399	4.701e-64	226.0	2DKXW@1|root,30TMD@2|Bacteria,1R3IE@1224|Proteobacteria,1SPK7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4410)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4410
TH1_k127_8355916_0	1283300.ATXB01000001_gene387	3.433e-169	539.0	COG1752@1|root,COG1752@2|Bacteria,1NT1Q@1224|Proteobacteria,1RP9M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
TH1_k127_8355916_3	1283300.ATXB01000001_gene398	1.063e-47	181.0	2ANC7@1|root,31DAQ@2|Bacteria,1NAR3@1224|Proteobacteria,1SWCU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_8372067_0	1116472.MGMO_136c00020	1.444e-162	523.0	COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria,1XF7M@135618|Methylococcales	135618|Methylococcales	G	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
TH1_k127_8372067_7	305700.B447_01516	4.841e-36	140.0	2CNK3@1|root,32SH9@2|Bacteria,1N02U@1224|Proteobacteria,2VUNW@28216|Betaproteobacteria,2KX0T@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of Unknown function (DUF2784)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2784
TH1_k127_8372067_9	1415779.JOMH01000001_gene809	3.97e-06	49.0	COG3039@1|root,COG3039@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
TH1_k127_8372067_5	857087.Metme_4130	8.403e-66	228.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,1RPMP@1236|Gammaproteobacteria,1XF7W@135618|Methylococcales	135618|Methylococcales	M	Peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802,ko:K03773	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C,FKBP_N
TH1_k127_8372067_8	1116472.MGMO_79c00110	7.657e-29	118.0	2AUUS@1|root,31KHZ@2|Bacteria,1QID8@1224|Proteobacteria,1TG7I@1236|Gammaproteobacteria,1XFV7@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_8372067_6	686340.Metal_3534	2.837e-40	152.0	2C3CF@1|root,32RRR@2|Bacteria,1MZUG@1224|Proteobacteria,1SS3S@1236|Gammaproteobacteria,1XGXJ@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF3175)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3175
TH1_k127_8372067_2	697282.Mettu_3833	1.307e-128	418.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,1S524@1236|Gammaproteobacteria,1XE6I@135618|Methylococcales	135618|Methylococcales	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TH1_k127_8372067_4	768671.ThimaDRAFT_2831	1.247e-98	324.0	COG0288@1|root,COG0288@2|Bacteria,1R3SC@1224|Proteobacteria,1RRB4@1236|Gammaproteobacteria,1WXB8@135613|Chromatiales	135613|Chromatiales	P	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
TH1_k127_8372067_1	697282.Mettu_4090	8.385e-136	439.0	COG0547@1|root,COG0547@2|Bacteria,1QJ8Q@1224|Proteobacteria,1RY26@1236|Gammaproteobacteria,1XEPN@135618|Methylococcales	135618|Methylococcales	E	PFAM Glycosyl transferase, family	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_trans_3N,Glycos_transf_3
TH1_k127_8372067_3	765911.Thivi_1205	2.983e-127	446.0	COG0784@1|root,COG0834@1|root,COG2198@1|root,COG4251@1|root,COG0784@2|Bacteria,COG0834@2|Bacteria,COG2198@2|Bacteria,COG4251@2|Bacteria,1NC9X@1224|Proteobacteria,1SVEC@1236|Gammaproteobacteria,1X2QI@135613|Chromatiales	135613|Chromatiales	T	Histidine Phosphotransfer domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS_3,Response_reg
TH1_k127_8424376_2	1116472.MGMO_53c01010	2.974e-115	376.0	COG3239@1|root,COG3239@2|Bacteria,1MY4I@1224|Proteobacteria,1S0IS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Fatty acid desaturase	-	-	1.14.19.23,1.14.19.45	ko:K10255	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
TH1_k127_8424376_4	686340.Metal_1082	1.171e-91	305.0	COG1611@1|root,COG1611@2|Bacteria,1RD59@1224|Proteobacteria,1S4C3@1236|Gammaproteobacteria,1XEGY@135618|Methylococcales	135618|Methylococcales	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
TH1_k127_8424376_1	1283300.ATXB01000001_gene792	3.243e-151	491.0	COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,1RN3U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Membrane-bound serine protease (ClpP class)	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
TH1_k127_8424376_3	1123517.JOMR01000001_gene846	9.019e-109	358.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,1RNW8@1236|Gammaproteobacteria,4600Q@72273|Thiotrichales	72273|Thiotrichales	O	PFAM SPFH domain Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
TH1_k127_8424376_0	1116472.MGMO_17c00180	3.752e-192	603.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1XDY0@135618|Methylococcales	135618|Methylococcales	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
TH1_k127_8439652_0	686340.Metal_1879	5.816e-100	335.0	28IA9@1|root,2Z9M7@2|Bacteria,1QTVI@1224|Proteobacteria,1T1IN@1236|Gammaproteobacteria,1XEN0@135618|Methylococcales	135618|Methylococcales	S	Iron-containing redox enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Haem_oxygenas_2
TH1_k127_8439652_1	697282.Mettu_2562	2.751e-91	307.0	COG4949@1|root,COG4949@2|Bacteria,1MVI2@1224|Proteobacteria,1RR20@1236|Gammaproteobacteria,1XETQ@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF3422)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3422
TH1_k127_8471913_1	443143.GM18_0461	1.875e-28	118.0	COG2197@1|root,COG2197@2|Bacteria,1NQH7@1224|Proteobacteria,42ZR0@68525|delta/epsilon subdivisions,2WT3B@28221|Deltaproteobacteria,43UQ9@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TH1_k127_8471913_0	443143.GM18_0462	8.045e-100	345.0	COG4585@1|root,COG4585@2|Bacteria,1RKV1@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TH1_k127_8475440_0	857087.Metme_2927	0.0	1294.0	COG0210@1|root,COG0514@1|root,COG0210@2|Bacteria,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,1RMPG@1236|Gammaproteobacteria,1XFYV@135618|Methylococcales	135618|Methylococcales	L	UvrD-like helicase C-terminal domain	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,UvrD_C
TH1_k127_8488506_2	857087.Metme_1876	1.186e-07	53.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1XDSN@135618|Methylococcales	135618|Methylococcales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
TH1_k127_8488506_0	857087.Metme_1877	2.623e-176	558.0	COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,1RMKU@1236|Gammaproteobacteria,1XDMK@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
TH1_k127_8488506_1	857087.Metme_1878	5.475e-106	347.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,1XDUD@135618|Methylococcales	135618|Methylococcales	E	Chorismate mutase type II	pheA	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
TH1_k127_8510939_1	857087.Metme_2360	3.008e-67	230.0	COG1156@1|root,COG1156@2|Bacteria,1R4RB@1224|Proteobacteria,1RQ6N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	-	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
TH1_k127_8510939_2	857087.Metme_2216	2.912e-13	76.0	2AW80@1|root,31N39@2|Bacteria,1QJUT@1224|Proteobacteria,1THW9@1236|Gammaproteobacteria,1XFVI@135618|Methylococcales	135618|Methylococcales	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
TH1_k127_8510939_0	1163617.SCD_n01945	6.169e-76	266.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,2VJUR@28216|Betaproteobacteria	28216|Betaproteobacteria	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
TH1_k127_8528496_0	857087.Metme_3844	1.773e-262	820.0	COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,1RMCN@1236|Gammaproteobacteria,1XDZX@135618|Methylococcales	135618|Methylococcales	P	PFAM Sulphate transporter	-	-	-	-	-	-	-	-	-	-	-	-	Sulfate_transp
TH1_k127_8528496_1	1116472.MGMO_85c00150	2.062e-95	320.0	COG4191@1|root,COG4191@2|Bacteria,1MVK7@1224|Proteobacteria,1S0T1@1236|Gammaproteobacteria,1XDN7@135618|Methylococcales	135618|Methylococcales	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TH1_k127_8566985_1	697282.Mettu_2893	2.95e-302	938.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1XDRZ@135618|Methylococcales	135618|Methylococcales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
TH1_k127_8566985_6	697282.Mettu_2894	2.539e-125	409.0	COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,1RMR9@1236|Gammaproteobacteria,1XDK0@135618|Methylococcales	135618|Methylococcales	J	Elongation factor P--(R)-beta-lysine ligase	-	-	-	ko:K04568	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	tRNA-synt_2
TH1_k127_8566985_7	686340.Metal_0145	8.644e-105	342.0	COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,1RPW7@1236|Gammaproteobacteria,1XE5P@135618|Methylococcales	135618|Methylococcales	J	Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
TH1_k127_8566985_5	697282.Mettu_2896	4.304e-134	435.0	COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,1RM84@1236|Gammaproteobacteria,1XEC3@135618|Methylococcales	135618|Methylococcales	C	PFAM Radical SAM	-	-	-	ko:K19810	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Fer4_12,Fer4_14,Radical_SAM
TH1_k127_8566985_3	697282.Mettu_1416	2.444e-182	572.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,1RNEJ@1236|Gammaproteobacteria,1XDRX@135618|Methylococcales	135618|Methylococcales	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.24,4.1.3.25,4.1.3.34	ko:K01644,ko:K08691	ko00630,ko00660,ko00680,ko00720,ko01120,ko01200,ko02020,map00630,map00660,map00680,map00720,map01120,map01200,map02020	M00346,M00373,M00376	R00237,R00362,R00473,R00934	RC00067,RC00307,RC00308,RC00311,RC00407,RC00502,RC01118,RC01205	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI
TH1_k127_8566985_2	697282.Mettu_1415	7.203e-209	653.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,1RMSU@1236|Gammaproteobacteria,1XDU5@135618|Methylococcales	135618|Methylococcales	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	-	-	6.2.1.9	ko:K14067	ko00630,ko00680,ko01120,ko01200,map00630,map00680,map01120,map01200	M00346	R01256	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
TH1_k127_8566985_4	686340.Metal_1988	5.706e-165	521.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,1RM7Y@1236|Gammaproteobacteria,1XGZC@135618|Methylococcales	135618|Methylococcales	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding,Ligase_CoA
TH1_k127_8566985_0	857087.Metme_4450	0.0	1479.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1XDXS@135618|Methylococcales	135618|Methylococcales	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
TH1_k127_861917_4	269482.Bcep1808_2168	1.086e-06	50.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2VI3Z@28216|Betaproteobacteria,1K04K@119060|Burkholderiaceae	28216|Betaproteobacteria	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
TH1_k127_861917_1	697282.Mettu_3791	1.539e-114	377.0	COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,1RMMB@1236|Gammaproteobacteria,1XDZ0@135618|Methylococcales	135618|Methylococcales	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
TH1_k127_861917_0	686340.Metal_2008	3.901e-196	618.0	COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,1RNKP@1236|Gammaproteobacteria,1XE2Z@135618|Methylococcales	135618|Methylococcales	O	Peptidase, M48	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
TH1_k127_861917_3	857087.Metme_0641	4.799e-80	270.0	COG1949@1|root,COG1949@2|Bacteria,1R9WX@1224|Proteobacteria,1S217@1236|Gammaproteobacteria,1XDZT@135618|Methylococcales	135618|Methylococcales	A	3'-to-5' exoribonuclease specific for small oligoribonucleotides	orn	-	-	ko:K13288	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	RNase_T
TH1_k127_861917_2	686340.Metal_2010	7.835e-89	301.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,1RNAQ@1236|Gammaproteobacteria,1XDIK@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
TH1_k127_8674436_1	697282.Mettu_3724	9.027e-261	814.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1XEVB@135618|Methylococcales	135618|Methylococcales	C	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
TH1_k127_8674436_5	697282.Mettu_3725	4.304e-47	175.0	COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,1S6FN@1236|Gammaproteobacteria,1XFGF@135618|Methylococcales	135618|Methylococcales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
TH1_k127_8674436_4	697282.Mettu_3727	5.915e-77	261.0	COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,1S65T@1236|Gammaproteobacteria,1XF7Z@135618|Methylococcales	135618|Methylococcales	C	Belongs to the complex I subunit 6 family	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
TH1_k127_8674436_3	697282.Mettu_3728	9.546e-108	349.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,1RN32@1236|Gammaproteobacteria,1XDQ1@135618|Methylococcales	135618|Methylococcales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
TH1_k127_8674436_2	697282.Mettu_3729	1.829e-176	559.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,1XEDP@135618|Methylococcales	135618|Methylococcales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
TH1_k127_8674436_0	697282.Mettu_3730	0.0	1170.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1XDTA@135618|Methylococcales	135618|Methylococcales	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4,Molybdop_Fe4S4,NADH-G_4Fe-4S_3
TH1_k127_8691223_2	697282.Mettu_2349	2.531e-44	162.0	COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,1RMG1@1236|Gammaproteobacteria,1XE9K@135618|Methylococcales	135618|Methylococcales	Q	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TH1_k127_8691223_0	697282.Mettu_2350	0.0	1093.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,1XE8W@135618|Methylococcales	135618|Methylococcales	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
TH1_k127_8691223_3	631362.Thi970DRAFT_00212	3.953e-33	130.0	2CEX2@1|root,32ZNR@2|Bacteria,1N9Q4@1224|Proteobacteria,1SSZW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_8691223_1	76114.ebA1549	8.49e-50	178.0	2E86T@1|root,332K1@2|Bacteria,1N2IR@1224|Proteobacteria,2W3G0@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_8716421_8	62928.azo0662	9.531e-46	167.0	COG5455@1|root,COG5455@2|Bacteria,1RJ9A@1224|Proteobacteria,2VRVC@28216|Betaproteobacteria,2KWPU@206389|Rhodocyclales	206389|Rhodocyclales	S	response to cobalt ion	-	-	-	-	-	-	-	-	-	-	-	-	RcnB
TH1_k127_8716421_4	686340.Metal_3930	9.487e-127	413.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,1T1NU@1236|Gammaproteobacteria,1XEVX@135618|Methylococcales	135618|Methylococcales	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
TH1_k127_8716421_11	1116472.MGMO_168c00030	3.928e-24	104.0	COG1773@1|root,COG1773@2|Bacteria,1N731@1224|Proteobacteria,1SC8Q@1236|Gammaproteobacteria,1XFQK@135618|Methylococcales	135618|Methylococcales	C	Rubredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
TH1_k127_8716421_10	857087.Metme_3847	3.76e-33	137.0	28UGB@1|root,2ZGM6@2|Bacteria,1P6GP@1224|Proteobacteria,1STQN@1236|Gammaproteobacteria,1XFII@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_8716421_3	697282.Mettu_2406	2.423e-139	458.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,1XDRI@135618|Methylococcales	135618|Methylococcales	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
TH1_k127_8716421_6	697282.Mettu_2407	3.58e-71	243.0	COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,1S62H@1236|Gammaproteobacteria,1XEZ2@135618|Methylococcales	135618|Methylococcales	U	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA	secB	-	-	ko:K03071	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03110	3.A.5	-	-	SecB
TH1_k127_8716421_7	857087.Metme_0272	2.059e-46	172.0	COG0607@1|root,COG0607@2|Bacteria,1MZ83@1224|Proteobacteria,1S8ZI@1236|Gammaproteobacteria,1XFMR@135618|Methylococcales	135618|Methylococcales	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TH1_k127_8716421_9	686340.Metal_2688	1.576e-45	167.0	COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,1SCH5@1236|Gammaproteobacteria,1XFKP@135618|Methylococcales	135618|Methylococcales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
TH1_k127_8716421_0	1116472.MGMO_128c00210	8.209e-243	758.0	COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,1RMJE@1236|Gammaproteobacteria,1XDNE@135618|Methylococcales	135618|Methylococcales	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	-	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
TH1_k127_8716421_5	697282.Mettu_2411	3.23e-92	316.0	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,1RPQP@1236|Gammaproteobacteria,1XF27@135618|Methylococcales	135618|Methylococcales	D	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TH1_k127_8716421_1	697282.Mettu_2412	8.756e-201	635.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1XEI9@135618|Methylococcales	135618|Methylococcales	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
TH1_k127_8716421_2	1485545.JQLW01000010_gene1512	6.121e-164	541.0	COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria	1224|Proteobacteria	P	COG0659 Sulfate permease and related transporters (MFS superfamily	bicA	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp,cNMP_binding
TH1_k127_8734830_4	857087.Metme_3414	7.259e-96	319.0	COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,1RPRF@1236|Gammaproteobacteria,1XDYC@135618|Methylococcales	135618|Methylococcales	J	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs	truD	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
TH1_k127_8734830_5	697282.Mettu_2489	3.558e-71	248.0	COG0850@1|root,COG0850@2|Bacteria,1RHVN@1224|Proteobacteria,1S6K8@1236|Gammaproteobacteria,1XEV4@135618|Methylococcales	135618|Methylococcales	D	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization	minC	-	-	ko:K03610	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	MinC_C,MinC_N
TH1_k127_8734830_1	857087.Metme_0712	4.25e-151	480.0	COG2894@1|root,COG2894@2|Bacteria,1MUEU@1224|Proteobacteria,1RNJ0@1236|Gammaproteobacteria,1XEDI@135618|Methylococcales	135618|Methylococcales	D	Belongs to the ParA family	minD	-	-	ko:K03609	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
TH1_k127_8734830_6	261292.Nit79A3_3451	9.656e-34	134.0	COG0851@1|root,COG0851@2|Bacteria,1N6QD@1224|Proteobacteria,2VTX1@28216|Betaproteobacteria,373AH@32003|Nitrosomonadales	28216|Betaproteobacteria	D	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell	minE	-	-	ko:K03608	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	MinE
TH1_k127_8734830_8	697282.Mettu_2486	1.932e-20	92.0	2BGZ0@1|root,32AZ4@2|Bacteria,1P5WT@1224|Proteobacteria,1ST5B@1236|Gammaproteobacteria,1XFQW@135618|Methylococcales	135618|Methylococcales	S	Winged helix-turn-helix domain (DUF2582)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2582
TH1_k127_8734830_0	1198232.CYCME_0811	9.081e-164	526.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,460CN@72273|Thiotrichales	72273|Thiotrichales	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
TH1_k127_8734830_7	857087.Metme_3343	1.59e-27	116.0	COG2878@1|root,COG2878@2|Bacteria,1MUWU@1224|Proteobacteria,1RNSJ@1236|Gammaproteobacteria,1XF61@135618|Methylococcales	135618|Methylococcales	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4_21
TH1_k127_8734830_3	697282.Mettu_1914	1.341e-99	328.0	COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,1RMHU@1236|Gammaproteobacteria,1XDNH@135618|Methylococcales	135618|Methylococcales	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
TH1_k127_8734830_2	1116472.MGMO_11c00620	7.412e-117	379.0	COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,1RQ9H@1236|Gammaproteobacteria,1XDX3@135618|Methylococcales	135618|Methylococcales	S	Belongs to the UPF0276 family	-	-	-	ko:K09930	-	-	-	-	ko00000	-	-	-	DUF692
TH1_k127_8762193_0	697282.Mettu_3243	6.132e-188	595.0	COG3391@1|root,COG3391@2|Bacteria,1QD5Q@1224|Proteobacteria,1RYUT@1236|Gammaproteobacteria,1XEKZ@135618|Methylococcales	135618|Methylococcales	S	PFAM Cytochrome d1	-	-	-	ko:K19345	-	-	-	-	ko00000	-	-	-	Cytochrom_D1
TH1_k127_8762193_5	933262.AXAM01000003_gene2814	5.11e-06	51.0	2E7P1@1|root,3324M@2|Bacteria,1Q68Q@1224|Proteobacteria,432MQ@68525|delta/epsilon subdivisions,2WYDU@28221|Deltaproteobacteria,2MPDC@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_8762193_4	891968.Anamo_0542	1.037e-12	70.0	COG1598@1|root,COG1598@2|Bacteria	2|Bacteria	N	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_8762193_2	697282.Mettu_3241	4.246e-33	131.0	COG2010@1|root,COG2010@2|Bacteria,1N73U@1224|Proteobacteria,1SFGZ@1236|Gammaproteobacteria,1XFNP@135618|Methylococcales	135618|Methylococcales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	ko:K19344	-	-	-	-	ko00000	-	-	-	Cytochrome_CBB3
TH1_k127_8762193_3	857087.Metme_4011	2.96e-31	125.0	COG2863@1|root,COG2863@2|Bacteria,1QI9P@1224|Proteobacteria,1TG3P@1236|Gammaproteobacteria,1XFFX@135618|Methylococcales	135618|Methylococcales	C	PFAM Cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
TH1_k127_8762193_1	857087.Metme_4012	2.575e-91	301.0	COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1PYK3@1224|Proteobacteria,1RR3N@1236|Gammaproteobacteria,1XDIJ@135618|Methylococcales	135618|Methylococcales	C	PFAM Cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Cytochrome_CBB3
TH1_k127_8764366_3	686340.Metal_0131	9.585e-55	195.0	COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,1RMRZ@1236|Gammaproteobacteria,1XEXV@135618|Methylococcales	135618|Methylococcales	J	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
TH1_k127_8764366_4	697282.Mettu_1746	0.0003341	44.0	COG0368@1|root,COG0368@2|Bacteria,1RHCC@1224|Proteobacteria,1S4TE@1236|Gammaproteobacteria,1XETM@135618|Methylococcales	135618|Methylococcales	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
TH1_k127_8764366_1	697282.Mettu_2145	1.659e-121	394.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,1XDZ7@135618|Methylococcales	135618|Methylococcales	D	PFAM Cobyrinic acid a,c-diamide synthase	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
TH1_k127_8764366_2	1116472.MGMO_20c00040	1.001e-120	393.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,1XE9B@135618|Methylococcales	135618|Methylococcales	K	Belongs to the ParB family	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	Crp,ParBc
TH1_k127_8764366_0	697282.Mettu_2029	1.221e-203	637.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,1RN76@1236|Gammaproteobacteria,1XDQT@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
TH1_k127_8789377_0	697282.Mettu_0314	1.054e-246	782.0	COG0744@1|root,COG0768@1|root,COG0744@2|Bacteria,COG0768@2|Bacteria,1NRPB@1224|Proteobacteria,1RNG3@1236|Gammaproteobacteria,1XEBS@135618|Methylococcales	135618|Methylococcales	M	Transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	Transgly
TH1_k127_8789377_3	857087.Metme_3498	1.319e-33	135.0	2939Q@1|root,2ZQSH@2|Bacteria,1P5RJ@1224|Proteobacteria,1SVBP@1236|Gammaproteobacteria,1XFHZ@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_8789377_1	697282.Mettu_0123	7.362e-167	539.0	2A8Z1@1|root,32CQ3@2|Bacteria,1QJGZ@1224|Proteobacteria,1THGT@1236|Gammaproteobacteria,1XDVK@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_8789377_2	857087.Metme_2788	7.438e-71	241.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1XDN6@135618|Methylococcales	135618|Methylococcales	H	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TH1_k127_8819556_1	857087.Metme_0521	2.327e-231	726.0	COG0659@1|root,COG0659@2|Bacteria,1MX8F@1224|Proteobacteria,1RRCQ@1236|Gammaproteobacteria,1XDYU@135618|Methylococcales	135618|Methylococcales	P	PFAM Sulfate transporter family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfate_transp
TH1_k127_8819556_2	1288494.EBAPG3_21310	2.446e-201	638.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2W13F@28216|Betaproteobacteria,3740B@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TH1_k127_8819556_0	697282.Mettu_2060	0.0	1225.0	COG3002@1|root,COG3002@2|Bacteria,1MX5K@1224|Proteobacteria,1RQC2@1236|Gammaproteobacteria,1XEJM@135618|Methylococcales	135618|Methylococcales	S	Belongs to the UPF0753 family	-	-	-	ko:K09822	-	-	-	-	ko00000	-	-	-	DUF2309
TH1_k127_8819556_4	1288494.EBAPG3_18850	4.772e-187	598.0	COG1009@1|root,COG1009@2|Bacteria,1R5G2@1224|Proteobacteria,2VZ5Y@28216|Betaproteobacteria,373B7@32003|Nitrosomonadales	28216|Betaproteobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M,Proton_antipo_N
TH1_k127_8819556_5	697282.Mettu_2064	3.174e-179	580.0	COG1008@1|root,COG1008@2|Bacteria,1R6UV@1224|Proteobacteria,1S0HQ@1236|Gammaproteobacteria,1XEP1@135618|Methylococcales	135618|Methylococcales	C	overlaps another CDS with the same product name	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TH1_k127_8819556_3	697282.Mettu_2065	2.066e-192	614.0	COG1008@1|root,COG1008@2|Bacteria,1R8V8@1224|Proteobacteria,1RZVG@1236|Gammaproteobacteria,1XEIN@135618|Methylococcales	135618|Methylococcales	C	overlaps another CDS with the same product name	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TH1_k127_8819556_7	573065.Astex_2217	2.488e-11	66.0	COG1442@1|root,COG1442@2|Bacteria,1MZZ2@1224|Proteobacteria,2UDCM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Glycosyl transferase family 8	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_8
TH1_k127_8819556_6	573065.Astex_2217	4.276e-24	104.0	COG1442@1|root,COG1442@2|Bacteria,1MZZ2@1224|Proteobacteria,2UDCM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Glycosyl transferase family 8	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_8
TH1_k127_8853353_2	857087.Metme_1917	6.093e-26	110.0	COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,1RQWB@1236|Gammaproteobacteria,1XDYN@135618|Methylococcales	135618|Methylococcales	O	Cytochrome oxidase assembly	-	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
TH1_k127_8853353_0	686340.Metal_0900	8.106e-59	211.0	COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,1S99V@1236|Gammaproteobacteria,1XF1M@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
TH1_k127_8882446_6	697282.Mettu_2794	1.687e-33	129.0	COG3252@1|root,COG3252@2|Bacteria,1MUP6@1224|Proteobacteria,1S1PA@1236|Gammaproteobacteria,1XDU9@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT	mch	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009987,GO:0015947,GO:0016787,GO:0016810,GO:0016814,GO:0018759,GO:0019238,GO:0043446,GO:0044237,GO:0071704	3.5.4.27	ko:K01499	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03464	RC01870	ko00000,ko00001,ko00002,ko01000	-	-	-	MCH
TH1_k127_8882446_2	697282.Mettu_2795	1.307e-131	425.0	COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,1S30B@1236|Gammaproteobacteria,1XE5K@135618|Methylococcales	135618|Methylococcales	HJ	Belongs to the RimK family	-	-	-	-	-	-	-	-	-	-	-	-	RimK
TH1_k127_8882446_3	1116472.MGMO_92c00120	9.736e-105	348.0	COG1767@1|root,COG1767@2|Bacteria,1RAWI@1224|Proteobacteria,1S4ZR@1236|Gammaproteobacteria,1XDPE@135618|Methylococcales	135618|Methylococcales	H	ATP:dephospho-CoA triphosphoribosyl transferase	-	-	2.4.2.52	ko:K05966	ko02020,map02020	-	R09675	RC00049,RC00063	ko00000,ko00001,ko01000	-	-	-	CitG
TH1_k127_8882446_4	697282.Mettu_2797	8.613e-90	298.0	COG1795@1|root,COG1795@2|Bacteria,1NDRY@1224|Proteobacteria,1S2AH@1236|Gammaproteobacteria,1XDXM@135618|Methylococcales	135618|Methylococcales	S	PFAM Formaldehyde-activating enzyme	-	-	4.2.1.147	ko:K10713	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R08058	RC01583,RC01795	ko00000,ko00001,ko01000	-	-	-	Fae
TH1_k127_8882446_5	686340.Metal_3520	2.164e-63	225.0	COG1411@1|root,COG1411@2|Bacteria,1RHWE@1224|Proteobacteria,1S8KI@1236|Gammaproteobacteria,1XF7T@135618|Methylococcales	135618|Methylococcales	S	Belongs to the HisA HisF family	-	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TH1_k127_8882446_0	686340.Metal_2917	2.678e-228	712.0	COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,1RNEW@1236|Gammaproteobacteria,1XDZN@135618|Methylococcales	135618|Methylococcales	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
TH1_k127_8882446_1	697282.Mettu_2977	5.658e-174	555.0	COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,1RPRQ@1236|Gammaproteobacteria,1XE8R@135618|Methylococcales	135618|Methylococcales	E	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
TH1_k127_8882446_7	1116472.MGMO_8c01140	7.045e-28	113.0	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RM8Z@1236|Gammaproteobacteria,1XDPP@135618|Methylococcales	135618|Methylococcales	O	HflC and HflK could regulate a protease	-	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
TH1_k127_8896787_25	686340.Metal_3309	2.639e-39	146.0	COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,1S5VT@1236|Gammaproteobacteria,1XFEB@135618|Methylococcales	135618|Methylococcales	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
TH1_k127_8896787_20	697282.Mettu_1328	1.552e-49	178.0	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,1S5XT@1236|Gammaproteobacteria,1XFAW@135618|Methylococcales	135618|Methylococcales	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
TH1_k127_8896787_6	857087.Metme_3810	3.433e-120	388.0	COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,1RN0P@1236|Gammaproteobacteria,1XEGS@135618|Methylococcales	135618|Methylococcales	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
TH1_k127_8896787_11	1116472.MGMO_66c00260	2.66e-72	245.0	COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,1S201@1236|Gammaproteobacteria,1XF05@135618|Methylococcales	135618|Methylococcales	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
TH1_k127_8896787_29	686340.Metal_3305	1.593e-17	83.0	COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,1SCBN@1236|Gammaproteobacteria,1XFTH@135618|Methylococcales	135618|Methylococcales	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
TH1_k127_8896787_26	857087.Metme_3807	5.989e-39	147.0	COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,1S8SS@1236|Gammaproteobacteria,1XFGP@135618|Methylococcales	135618|Methylococcales	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
TH1_k127_8896787_13	697282.Mettu_1323	3.779e-68	232.0	COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,1S3Z3@1236|Gammaproteobacteria,1XF3P@135618|Methylococcales	135618|Methylococcales	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
TH1_k127_8896787_22	640081.Dsui_0348	6.293e-44	162.0	COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,2VUC6@28216|Betaproteobacteria,2KWPF@206389|Rhodocyclales	206389|Rhodocyclales	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
TH1_k127_8896787_8	686340.Metal_3301	3.723e-93	308.0	COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,1RPE1@1236|Gammaproteobacteria,1XEFF@135618|Methylococcales	135618|Methylococcales	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
TH1_k127_8896787_21	857087.Metme_3803	5.564e-46	168.0	COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,1S62N@1236|Gammaproteobacteria,1XFDK@135618|Methylococcales	135618|Methylococcales	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
TH1_k127_8896787_14	857087.Metme_3802	2.203e-64	222.0	COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,1S452@1236|Gammaproteobacteria,1XF72@135618|Methylococcales	135618|Methylococcales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
TH1_k127_8896787_10	697282.Mettu_1318	2.263e-74	253.0	COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,1S1Z1@1236|Gammaproteobacteria,1XEM5@135618|Methylococcales	135618|Methylococcales	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
TH1_k127_8896787_23	697282.Mettu_1317	1.199e-43	161.0	COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,1S5V2@1236|Gammaproteobacteria,1XFB0@135618|Methylococcales	135618|Methylococcales	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
TH1_k127_8896787_9	1116472.MGMO_66c00360	8.306e-87	288.0	COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,1RNEV@1236|Gammaproteobacteria,1XERY@135618|Methylococcales	135618|Methylococcales	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
TH1_k127_8896787_28	857087.Metme_3798	1.027e-20	94.0	COG1841@1|root,COG1841@2|Bacteria,1N6ZE@1224|Proteobacteria,1SC8N@1236|Gammaproteobacteria,1XFTY@135618|Methylococcales	135618|Methylococcales	J	Ribosomal protein L30	rpmD	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
TH1_k127_8896787_16	697282.Mettu_1314	2.025e-62	217.0	COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,1S3P6@1236|Gammaproteobacteria,1XF8B@135618|Methylococcales	135618|Methylococcales	J	Binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
TH1_k127_8896787_2	697282.Mettu_1313	1.347e-242	753.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,1RNJV@1236|Gammaproteobacteria,1XE0M@135618|Methylococcales	135618|Methylococcales	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
TH1_k127_8896787_30	1049564.TevJSym_aa00230	2.944e-14	73.0	COG0257@1|root,COG0257@2|Bacteria,1NGEI@1224|Proteobacteria,1SGC9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
TH1_k127_8896787_18	686340.Metal_3291	3.087e-58	203.0	COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,1S3NX@1236|Gammaproteobacteria,1XF6W@135618|Methylococcales	135618|Methylococcales	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
TH1_k127_8896787_12	1116472.MGMO_66c00410	1.788e-71	242.0	COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,1S3Q2@1236|Gammaproteobacteria,1XEXU@135618|Methylococcales	135618|Methylococcales	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
TH1_k127_8896787_7	697282.Mettu_1309	6.799e-109	354.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,1RQ38@1236|Gammaproteobacteria,1XETZ@135618|Methylococcales	135618|Methylococcales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
TH1_k127_8896787_5	697282.Mettu_1308	6.514e-167	529.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,1RMU3@1236|Gammaproteobacteria,1XE7D@135618|Methylococcales	135618|Methylococcales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
TH1_k127_8896787_17	697282.Mettu_1307	1.825e-58	206.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,1S3QK@1236|Gammaproteobacteria,1XF55@135618|Methylococcales	135618|Methylococcales	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
TH1_k127_8896787_15	1116472.MGMO_66c00450	1.132e-63	218.0	COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,1S5ZK@1236|Gammaproteobacteria,1XFBB@135618|Methylococcales	135618|Methylococcales	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	-	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	DUF3470,Fer4
TH1_k127_8896787_0	697282.Mettu_2187	0.0	1349.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1XEFJ@135618|Methylococcales	135618|Methylococcales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
TH1_k127_8896787_4	697282.Mettu_1260	7.219e-228	712.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,1XESK@135618|Methylococcales	135618|Methylococcales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
TH1_k127_8896787_27	857087.Metme_1672	6.532e-28	114.0	COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,1SCSR@1236|Gammaproteobacteria,1XFGX@135618|Methylococcales	135618|Methylococcales	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
TH1_k127_8896787_1	697282.Mettu_2548	0.0	1018.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1XE2K@135618|Methylococcales	135618|Methylococcales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	spoT	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
TH1_k127_8896787_19	396588.Tgr7_3184	2.465e-56	201.0	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,1S5XS@1236|Gammaproteobacteria,1WY7E@135613|Chromatiales	135613|Chromatiales	J	PFAM Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
TH1_k127_8896787_3	697282.Mettu_2546	1.472e-241	758.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,1XE3Z@135618|Methylococcales	135618|Methylococcales	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
TH1_k127_8909900_0	697282.Mettu_0466	1.591e-122	398.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNXA@1236|Gammaproteobacteria,1XE62@135618|Methylococcales	135618|Methylococcales	E	PFAM Aminotransferase, class I	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
TH1_k127_8909900_2	1116472.MGMO_53c00220	1.5e-74	252.0	COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,1S47H@1236|Gammaproteobacteria,1XF2E@135618|Methylococcales	135618|Methylococcales	T	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
TH1_k127_8909900_1	697282.Mettu_0468	8.57e-106	351.0	COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,1RMYQ@1236|Gammaproteobacteria,1XE3T@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon	gluQ	-	-	ko:K01894	-	-	-	-	ko00000,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c
TH1_k127_8919666_9	395494.Galf_1580	3.219e-35	141.0	COG2370@1|root,COG2370@2|Bacteria,1N08F@1224|Proteobacteria,2VTYR@28216|Betaproteobacteria	28216|Betaproteobacteria	O	HupE UreJ protein	ureJ	-	-	ko:K03192	-	-	-	-	ko00000	-	-	-	HupE_UreJ
TH1_k127_8919666_0	1116472.MGMO_54c00100	4.28e-249	781.0	COG2211@1|root,COG2211@2|Bacteria,1MWSH@1224|Proteobacteria,1S124@1236|Gammaproteobacteria,1XEG3@135618|Methylococcales	135618|Methylococcales	G	BT1 family	-	-	-	-	-	-	-	-	-	-	-	-	BT1
TH1_k127_8919666_2	697282.Mettu_1356	9.445e-189	594.0	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,1XEPW@135618|Methylococcales	135618|Methylococcales	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
TH1_k127_8919666_1	697282.Mettu_1355	2.761e-207	651.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1XDJU@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
TH1_k127_8919666_4	697282.Mettu_1354	1.769e-171	556.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,1RQIX@1236|Gammaproteobacteria,1XE13@135618|Methylococcales	135618|Methylococcales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
TH1_k127_8919666_8	1116472.MGMO_88c00090	2.135e-39	153.0	COG3017@1|root,COG3017@2|Bacteria,1QJPB@1224|Proteobacteria,1THQ9@1236|Gammaproteobacteria,1XFAB@135618|Methylococcales	135618|Methylococcales	M	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein	-	-	-	ko:K02494	-	-	-	-	ko00000	-	-	-	LolB
TH1_k127_8919666_5	697282.Mettu_1352	2.242e-121	396.0	COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,1RP23@1236|Gammaproteobacteria,1XE84@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
TH1_k127_8919666_3	697282.Mettu_1351	3.803e-175	552.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,1RMUC@1236|Gammaproteobacteria,1XDXQ@135618|Methylococcales	135618|Methylococcales	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
TH1_k127_8919666_6	857087.Metme_3832	7.756e-77	262.0	COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,1S46A@1236|Gammaproteobacteria,1XEUB@135618|Methylococcales	135618|Methylococcales	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
TH1_k127_8919666_7	1116472.MGMO_88c00040	1.055e-58	208.0	COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,1RPK3@1236|Gammaproteobacteria,1XF29@135618|Methylococcales	135618|Methylococcales	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
TH1_k127_895032_3	686340.Metal_1483	3.827e-20	91.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,1T1MS@1236|Gammaproteobacteria,1XH11@135618|Methylococcales	135618|Methylococcales	P	Transporter associated domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
TH1_k127_895032_4	631362.Thi970DRAFT_04985	6.24e-17	84.0	COG3385@1|root,COG5659@1|root,COG3385@2|Bacteria,COG5659@2|Bacteria,1R97Q@1224|Proteobacteria,1RRDP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
TH1_k127_895032_1	697282.Mettu_2479	5.075e-73	250.0	COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,1S6D0@1236|Gammaproteobacteria,1XEYT@135618|Methylococcales	135618|Methylococcales	S	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate	-	-	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_3
TH1_k127_895032_6	388051.AUFE01000013_gene2782	1.357e-08	66.0	COG3117@1|root,COG3117@2|Bacteria,1R5UK@1224|Proteobacteria,2VU37@28216|Betaproteobacteria,1K3FT@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Lipopolysaccharide-assembly, LptC-related	lptC	-	-	ko:K11719	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptC
TH1_k127_895032_2	697282.Mettu_2481	5.575e-53	192.0	COG1934@1|root,COG1934@2|Bacteria,1N776@1224|Proteobacteria,1RPM7@1236|Gammaproteobacteria,1XF8P@135618|Methylococcales	135618|Methylococcales	S	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm	lptA	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
TH1_k127_895032_0	697282.Mettu_2482	3.455e-117	381.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,1RPW1@1236|Gammaproteobacteria,1XEEF@135618|Methylococcales	135618|Methylococcales	S	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
TH1_k127_895032_5	243233.MCA0741	7.448e-10	61.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,1RMY0@1236|Gammaproteobacteria,1XEW0@135618|Methylococcales	135618|Methylococcales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
TH1_k127_8960807_0	243233.MCA0335	0.0	1726.0	COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1PE6F@1224|Proteobacteria,1RWQP@1236|Gammaproteobacteria,1XDNM@135618|Methylococcales	135618|Methylococcales	CEH	2 iron, 2 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
TH1_k127_8964514_2	697282.Mettu_1624	1.374e-37	145.0	COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,1RPBN@1236|Gammaproteobacteria,1XEU6@135618|Methylococcales	135618|Methylococcales	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
TH1_k127_8964514_3	697282.Mettu_1623	2.071e-37	146.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria,1XEFM@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TH1_k127_8964514_0	857087.Metme_3575	2.218e-178	563.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,1XE3A@135618|Methylococcales	135618|Methylococcales	C	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
TH1_k127_8964514_1	697282.Mettu_0797	3.443e-63	223.0	COG5544@1|root,COG5544@2|Bacteria,1QU58@1224|Proteobacteria,1RYPH@1236|Gammaproteobacteria,1XDSJ@135618|Methylococcales	135618|Methylococcales	S	Lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_8968438_1	697282.Mettu_2372	3.367e-113	374.0	COG4409@1|root,COG4409@2|Bacteria,1MVUD@1224|Proteobacteria,1S27X@1236|Gammaproteobacteria,1XF6U@135618|Methylococcales	135618|Methylococcales	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_8968438_2	697282.Mettu_0488	1.287e-55	199.0	COG0526@1|root,COG0526@2|Bacteria,1MZ9B@1224|Proteobacteria,1SBA1@1236|Gammaproteobacteria,1XFEH@135618|Methylococcales	135618|Methylococcales	CO	thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_8968438_0	765911.Thivi_1324	0.0	1246.0	COG0366@1|root,COG0366@2|Bacteria,1MU90@1224|Proteobacteria,1RQ1S@1236|Gammaproteobacteria,1WWPV@135613|Chromatiales	135613|Chromatiales	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,CBM26,Cyc-maltodext_C,Cyc-maltodext_N
TH1_k127_8968531_2	697282.Mettu_0785	3.503e-12	66.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,1XESA@135618|Methylococcales	135618|Methylococcales	H	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
TH1_k127_8968531_1	697282.Mettu_2447	3.344e-13	72.0	COG1598@1|root,COG1598@2|Bacteria,1NMQ9@1224|Proteobacteria,1SJ5A@1236|Gammaproteobacteria,1XFVK@135618|Methylococcales	135618|Methylococcales	S	PFAM Uncharacterised protein family (UPF0150)	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_8968531_0	697282.Mettu_0789	1.201e-171	546.0	COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,1RMV5@1236|Gammaproteobacteria,1XEGB@135618|Methylococcales	135618|Methylococcales	E	Belongs to the acetyltransferase family. ArgA subfamily	argA	-	2.3.1.1	ko:K14682	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,Acetyltransf_1
TH1_k127_8984822_0	870187.Thini_3436	4.027e-111	366.0	COG1262@1|root,COG1262@2|Bacteria,1PGVZ@1224|Proteobacteria,1SM2E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
TH1_k127_8985125_2	697282.Mettu_2899	3.014e-22	99.0	COG2716@1|root,COG2716@2|Bacteria,1R7W7@1224|Proteobacteria,1RSDP@1236|Gammaproteobacteria,1XF4Y@135618|Methylococcales	135618|Methylococcales	E	ACT domain	-	-	-	ko:K03567	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	ACT_6
TH1_k127_8985125_3	1116472.MGMO_41c00160	2.599e-17	83.0	COG2716@1|root,COG2716@2|Bacteria,1R7W7@1224|Proteobacteria,1RSDP@1236|Gammaproteobacteria,1XF4Y@135618|Methylococcales	135618|Methylococcales	E	ACT domain	-	-	-	ko:K03567	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	ACT_6
TH1_k127_8985125_1	697282.Mettu_2900	2.525e-58	215.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,1RQ7F@1236|Gammaproteobacteria,1XF8T@135618|Methylococcales	135618|Methylococcales	O	Redoxin	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
TH1_k127_8985125_0	697282.Mettu_2901	1.219e-186	589.0	COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,1RMQN@1236|Gammaproteobacteria,1XE19@135618|Methylococcales	135618|Methylococcales	T	PFAM PhoH-like protein	-	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
TH1_k127_9004517_0	697282.Mettu_4208	0.0	1004.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1XE3E@135618|Methylococcales	135618|Methylococcales	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0003674,GO:0003824,GO:0004654,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
TH1_k127_9004517_1	1283300.ATXB01000001_gene977	2.022e-32	130.0	COG1669@1|root,COG1669@2|Bacteria,1RH50@1224|Proteobacteria,1SBXX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	DNA polymerase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
TH1_k127_900812_2	697282.Mettu_0019	1.141e-53	192.0	COG0735@1|root,COG0735@2|Bacteria,1MZIW@1224|Proteobacteria,1S5ZI@1236|Gammaproteobacteria,1XF43@135618|Methylococcales	135618|Methylococcales	P	Belongs to the Fur family	-	-	-	ko:K09823	ko02024,map02024	-	-	-	ko00000,ko00001,ko03000	-	-	-	FUR
TH1_k127_900812_3	1116472.MGMO_223c00010	6.278e-51	187.0	29HEN@1|root,304C1@2|Bacteria,1QJNM@1224|Proteobacteria,1THPG@1236|Gammaproteobacteria,1XF6S@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF4124)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124
TH1_k127_900812_1	395493.BegalDRAFT_1387	2.544e-58	208.0	COG3707@1|root,COG3707@2|Bacteria,1MXDV@1224|Proteobacteria,1S3YY@1236|Gammaproteobacteria,4611P@72273|Thiotrichales	72273|Thiotrichales	T	PFAM response regulator receiver	-	-	-	ko:K07183	-	-	-	-	ko00000,ko02022	-	-	-	ANTAR,Response_reg
TH1_k127_900812_0	768671.ThimaDRAFT_4416	2.962e-143	465.0	COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,1RPUP@1236|Gammaproteobacteria,1X036@135613|Chromatiales	135613|Chromatiales	P	NMT1-like family	-	-	-	ko:K15576	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16.1,3.A.1.16.2	-	-	NMT1_2
TH1_k127_900812_4	269797.Mbar_A0582	1.806e-30	127.0	COG3271@1|root,arCOG06761@2157|Archaea,2Y40P@28890|Euryarchaeota	28890|Euryarchaeota	S	Peptidase C39 family	-	-	-	ko:K06992	-	-	-	-	ko00000	-	-	-	Peptidase_C39_2
TH1_k127_9025827_1	663610.JQKO01000001_gene622	1.82e-286	886.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2TSB8@28211|Alphaproteobacteria,3NAFW@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	Sulfatase	aslA	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	DUF4994,Sulfatase,Sulfatase_C
TH1_k127_9025827_10	566466.NOR53_1467	2.405e-07	54.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1J56J@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Small-conductance mechanosensitive channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel,MscS_TM,MscS_porin
TH1_k127_9025827_7	153948.NAL212_1795	8.252e-30	120.0	2DUS0@1|root,33RYR@2|Bacteria,1NS4C@1224|Proteobacteria,2WDS9@28216|Betaproteobacteria,3747E@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_9025827_8	1301098.PKB_1750	1.41e-20	96.0	2C0Z5@1|root,30A8M@2|Bacteria,1QT69@1224|Proteobacteria,1STUY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_9025827_3	314278.NB231_02263	1.102e-66	235.0	2A5PE@1|root,30UE9@2|Bacteria,1PX3T@1224|Proteobacteria,1TA9Y@1236|Gammaproteobacteria,1WZSR@135613|Chromatiales	135613|Chromatiales	M	Protein of unknown function (DUF3313)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3313
TH1_k127_9025827_2	1266914.ATUK01000005_gene2608	3.241e-81	286.0	COG1075@1|root,COG1075@2|Bacteria,1R5PF@1224|Proteobacteria,1S87U@1236|Gammaproteobacteria,1WZUV@135613|Chromatiales	135613|Chromatiales	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	DUF915,LCAT,PGAP1
TH1_k127_9025827_6	375286.mma_0692	1.552e-31	129.0	COG4574@1|root,COG4574@2|Bacteria,1MZEN@1224|Proteobacteria,2VUFF@28216|Betaproteobacteria,4773R@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Ecotin	eco	-	-	ko:K08276	-	-	-	-	ko00000	-	-	-	Ecotin
TH1_k127_9025827_11	290317.Cpha266_2522	0.0005378	48.0	COG0668@1|root,COG0668@2|Bacteria	2|Bacteria	M	transmembrane transport	-	-	-	ko:K03442,ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.2,1.A.23.3	-	-	LysM,MS_channel,Mu-transpos_C,rve
TH1_k127_9025827_9	1121921.KB898706_gene2431	2.698e-19	89.0	COG0668@1|root,COG0668@2|Bacteria,1N66N@1224|Proteobacteria,1RQWI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
TH1_k127_9025827_0	697282.Mettu_4184	8.981e-305	937.0	2F6U8@1|root,33ZAC@2|Bacteria,1NYBF@1224|Proteobacteria,1THMC@1236|Gammaproteobacteria,1XEUE@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_9025827_5	686340.Metal_1959	2.919e-40	151.0	2AYI2@1|root,31QMN@2|Bacteria,1PW2J@1224|Proteobacteria,1TI31@1236|Gammaproteobacteria,1XGDU@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_902970_9	743720.Psefu_3661	1.375e-10	61.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,1RMZD@1236|Gammaproteobacteria,1YWTY@136845|Pseudomonas putida group	1236|Gammaproteobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
TH1_k127_902970_1	686340.Metal_0300	1.762e-137	449.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1XEPR@135618|Methylococcales	135618|Methylococcales	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TH1_k127_902970_4	697282.Mettu_0175	1.107e-97	322.0	COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,1RP9H@1236|Gammaproteobacteria,1XE9E@135618|Methylococcales	135618|Methylococcales	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petA	-	1.10.2.2	ko:K00411	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,UCR_Fe-S_N
TH1_k127_902970_0	857087.Metme_0675	1.036e-251	783.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,1RNCP@1236|Gammaproteobacteria,1XECN@135618|Methylococcales	135618|Methylococcales	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petB	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
TH1_k127_902970_3	857087.Metme_0674	1.08e-100	333.0	COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,1RN4Y@1236|Gammaproteobacteria,1XE3J@135618|Methylococcales	135618|Methylococcales	C	Cytochrome C1	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C1
TH1_k127_902970_2	697282.Mettu_0172	6.031e-101	332.0	COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,1RP12@1236|Gammaproteobacteria,1XDPJ@135618|Methylococcales	135618|Methylococcales	O	PFAM Glutathione S-transferase, N-terminal	sspA	-	-	ko:K03599	-	-	-	-	ko00000,ko02000,ko03021	1.A.12.3.1	-	-	GST_C,GST_N_3
TH1_k127_902970_6	697282.Mettu_0171	1.353e-54	194.0	COG2969@1|root,COG2969@2|Bacteria,1MZ2Q@1224|Proteobacteria,1S8WT@1236|Gammaproteobacteria,1XFC6@135618|Methylococcales	135618|Methylococcales	S	PFAM Stringent starvation protein B	sspB	-	-	ko:K03600	-	-	-	-	ko00000,ko03021	-	-	-	SspB
TH1_k127_902970_8	1279017.AQYJ01000024_gene980	9.087e-33	129.0	COG4517@1|root,COG4517@2|Bacteria,1MZJX@1224|Proteobacteria,1S95D@1236|Gammaproteobacteria,467KQ@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Domain of unknown function (DUF1820)	IV02_29925	-	-	-	-	-	-	-	-	-	-	-	DUF1820
TH1_k127_902970_5	686340.Metal_0165	2.872e-66	237.0	COG3219@1|root,COG3219@2|Bacteria,1R8C9@1224|Proteobacteria,1S23S@1236|Gammaproteobacteria,1XEQC@135618|Methylococcales	135618|Methylococcales	S	Putative DNA-binding domain	-	-	-	ko:K09929	-	-	-	-	ko00000	-	-	-	DUF2063
TH1_k127_902970_7	1116472.MGMO_11c00620	2.938e-36	138.0	COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,1RQ9H@1236|Gammaproteobacteria,1XDX3@135618|Methylococcales	135618|Methylococcales	S	Belongs to the UPF0276 family	-	-	-	ko:K09930	-	-	-	-	ko00000	-	-	-	DUF692
TH1_k127_9052275_3	1121406.JAEX01000001_gene93	9.634e-109	364.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,42R6N@68525|delta/epsilon subdivisions,2WKF4@28221|Deltaproteobacteria,2M8KJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
TH1_k127_9052275_2	105559.Nwat_0657	1.035e-125	416.0	COG0438@1|root,COG0438@2|Bacteria,1N0DG@1224|Proteobacteria,1S0D6@1236|Gammaproteobacteria,1WY3U@135613|Chromatiales	135613|Chromatiales	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_2,Glycos_transf_1
TH1_k127_9052275_4	390235.PputW619_1412	2.339e-90	307.0	COG0451@1|root,COG0451@2|Bacteria,1MX2J@1224|Proteobacteria,1RPHW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	epimerase dehydratase	wbpV	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
TH1_k127_9052275_5	748247.AZKH_3757	2.431e-79	276.0	COG0472@1|root,COG0472@2|Bacteria,1MWYW@1224|Proteobacteria,2VQW6@28216|Betaproteobacteria,2KX61@206389|Rhodocyclales	206389|Rhodocyclales	M	Glycosyl transferase family 4	-	-	-	ko:K13007	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
TH1_k127_9052275_0	857087.Metme_1198	2.465e-265	829.0	COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,1RNQ2@1236|Gammaproteobacteria,1XEF1@135618|Methylococcales	135618|Methylococcales	GM	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
TH1_k127_9052275_6	1265505.ATUG01000002_gene1332	1.776e-19	91.0	2CC6G@1|root,32Y5Q@2|Bacteria,1N79B@1224|Proteobacteria,42VUW@68525|delta/epsilon subdivisions,2WRRP@28221|Deltaproteobacteria,2MNZ6@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of Unknown Function with PDB structure (DUF3862)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3862
TH1_k127_9052275_1	697282.Mettu_1765	1.137e-136	440.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,1S54V@1236|Gammaproteobacteria,1XEHH@135618|Methylococcales	135618|Methylococcales	K	HTH transcriptional regulator, LysR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TH1_k127_9069293_5	697282.Mettu_0705	1.785e-91	307.0	COG1276@1|root,COG1276@2|Bacteria,1MXRN@1224|Proteobacteria,1SKDQ@1236|Gammaproteobacteria,1XDKC@135618|Methylococcales	135618|Methylococcales	P	Copper resistance	-	-	-	ko:K07245	-	-	-	-	ko00000,ko02000	9.B.62.1	-	-	CopD
TH1_k127_9069293_8	686340.Metal_2863	1.433e-28	120.0	COG2372@1|root,COG2372@2|Bacteria,1QJS2@1224|Proteobacteria,1SSRQ@1236|Gammaproteobacteria,1XFMP@135618|Methylococcales	135618|Methylococcales	S	CopC domain	-	-	-	ko:K07156	-	-	-	-	ko00000,ko02000	9.B.62.2	-	-	CopC
TH1_k127_9069293_1	857087.Metme_3476	1.117e-240	749.0	COG4992@1|root,COG4992@2|Bacteria,1R6U9@1224|Proteobacteria,1RMRF@1236|Gammaproteobacteria,1XEQV@135618|Methylococcales	135618|Methylococcales	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.13	ko:K00819	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R00667	RC00006,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
TH1_k127_9069293_7	697282.Mettu_0709	4.308e-53	195.0	COG0775@1|root,COG0775@2|Bacteria,1PETT@1224|Proteobacteria,1THNW@1236|Gammaproteobacteria,1XF47@135618|Methylococcales	135618|Methylococcales	F	TIGRFAM Hopanoid-associated phosphorylase	-	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
TH1_k127_9069293_0	697282.Mettu_0710	0.0	1104.0	COG1657@1|root,COG1657@2|Bacteria,1MUIP@1224|Proteobacteria,1S118@1236|Gammaproteobacteria,1XEH0@135618|Methylococcales	135618|Methylococcales	I	Squalene-hopene cyclase C-terminal domain	-	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
TH1_k127_9069293_3	697282.Mettu_0711	5.579e-180	569.0	COG1562@1|root,COG1562@2|Bacteria,1R4ZD@1224|Proteobacteria,1RS93@1236|Gammaproteobacteria,1XE11@135618|Methylococcales	135618|Methylococcales	I	PFAM Squalene phytoene synthase	-	-	2.5.1.21	ko:K00801	ko00100,ko00909,ko01100,ko01110,ko01130,map00100,map00909,map01100,map01110,map01130	-	R00702,R02872,R06223	RC00362,RC00796,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	SQS_PSY
TH1_k127_9069293_2	857087.Metme_3472	2.235e-204	640.0	COG0535@1|root,COG0535@2|Bacteria,1MXM1@1224|Proteobacteria,1RNQ1@1236|Gammaproteobacteria,1XEET@135618|Methylococcales	135618|Methylococcales	S	TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnH	-	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Fer4_14,Radical_SAM
TH1_k127_9069293_6	697282.Mettu_0713	1.421e-79	270.0	COG2854@1|root,COG2854@2|Bacteria,1N275@1224|Proteobacteria,1SB2V@1236|Gammaproteobacteria,1XE7V@135618|Methylococcales	135618|Methylococcales	Q	PFAM Toluene tolerance	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
TH1_k127_9069293_4	697282.Mettu_0714	1.761e-94	323.0	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,1RNPS@1236|Gammaproteobacteria,1XDWJ@135618|Methylococcales	135618|Methylococcales	M	(Lipo)protein	-	-	-	-	-	-	-	-	-	-	-	-	MlaA
TH1_k127_9069293_9	1283300.ATXB01000001_gene1485	0.0007427	42.0	COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,1RMYQ@1236|Gammaproteobacteria,1XE3T@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon	gluQ	-	-	ko:K01894	-	-	-	-	ko00000,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c
TH1_k127_911885_4	243233.MCA1764	8.261e-82	282.0	COG0745@1|root,COG0745@2|Bacteria,1MY5Y@1224|Proteobacteria,1RYIX@1236|Gammaproteobacteria,1XEXF@135618|Methylococcales	135618|Methylococcales	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TH1_k127_911885_2	1116472.MGMO_125c00060	1.254e-176	564.0	COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,1RQGM@1236|Gammaproteobacteria,1XE10@135618|Methylococcales	135618|Methylococcales	T	Histidine kinase	-	-	2.7.13.3	ko:K07649	ko02020,map02020	M00457	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	2CSK_N,HATPase_c,HisKA
TH1_k127_911885_5	1121939.L861_23695	1.164e-06	53.0	COG3630@1|root,COG3630@2|Bacteria,1NHYS@1224|Proteobacteria,1SGS8@1236|Gammaproteobacteria,1XM8S@135619|Oceanospirillales	135619|Oceanospirillales	C	Lyase and sodium transporter	oadG	-	4.1.1.3	ko:K01573	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_gamma
TH1_k127_911885_0	686340.Metal_1995	5.415e-267	835.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,1RNG6@1236|Gammaproteobacteria,1XEWN@135618|Methylococcales	135618|Methylococcales	CI	Oxaloacetate decarboxylase, alpha subunit	-	-	4.1.1.3	ko:K01571	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
TH1_k127_911885_1	697282.Mettu_2617	1.333e-197	623.0	COG1883@1|root,COG1883@2|Bacteria,1MV0G@1224|Proteobacteria,1RP3W@1236|Gammaproteobacteria,1XE74@135618|Methylococcales	135618|Methylococcales	C	decarboxylase, beta subunit	oadB	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
TH1_k127_911885_3	1117958.PE143B_0101130	1.887e-135	448.0	COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	morA	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_8,PAS_9,dCache_2
TH1_k127_9131525_2	697282.Mettu_4285	1.176e-115	374.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RMGJ@1236|Gammaproteobacteria,1XES5@135618|Methylococcales	135618|Methylococcales	H	HI0933-like protein	-	-	1.14.99.44	ko:K10210	ko00906,map00906	-	R07654,R09671,R09727,R09728	RC00254,RC02089,RC02626,RC02638	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
TH1_k127_9131525_1	857087.Metme_3773	4.774e-233	732.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1XEU4@135618|Methylococcales	135618|Methylococcales	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.99.10	ko:K22445	-	-	-	-	ko00000,ko01000	-	-	-	Aldedh
TH1_k127_9131525_0	857087.Metme_3772	1.087e-270	839.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RMGJ@1236|Gammaproteobacteria,1XEWM@135618|Methylococcales	135618|Methylococcales	Q	Flavin containing amine oxidoreductase	-	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
TH1_k127_9131525_3	697282.Mettu_2460	2.48e-49	177.0	COG0853@1|root,COG0853@2|Bacteria,1RI1B@1224|Proteobacteria,1S66E@1236|Gammaproteobacteria,1XFAU@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
TH1_k127_9134926_1	697282.Mettu_3365	2.72e-40	155.0	2C5IB@1|root,2ZVNU@2|Bacteria,1P5N1@1224|Proteobacteria,1SUUE@1236|Gammaproteobacteria,1XFP4@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_9134926_0	686340.Metal_1041	1.81e-149	477.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1XDY0@135618|Methylococcales	135618|Methylococcales	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
TH1_k127_9159114_1	243233.MCA0768	4.131e-141	454.0	COG0167@1|root,COG0167@2|Bacteria,1MXER@1224|Proteobacteria,1RRTA@1236|Gammaproteobacteria,1XDK5@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
TH1_k127_9159114_0	243233.MCA0769	0.0	1339.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1XE3B@135618|Methylococcales	135618|Methylococcales	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
TH1_k127_9185397_1	697282.Mettu_4262	2.851e-136	451.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,1XETE@135618|Methylococcales	135618|Methylococcales	M	Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA_C
TH1_k127_9185397_3	686340.Metal_2633	3.712e-124	408.0	COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,1RQ1Q@1236|Gammaproteobacteria,1XDY9@135618|Methylococcales	135618|Methylococcales	S	Phosphotransferase enzyme family	-	-	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH
TH1_k127_9185397_5	686340.Metal_2632	1.909e-83	285.0	COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,1S23A@1236|Gammaproteobacteria,1XE24@135618|Methylococcales	135618|Methylococcales	JM	PFAM Nucleotidyl transferase	-	-	2.7.7.99	ko:K00992	ko00520,ko01100,map00520,map01100	-	R11025	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
TH1_k127_9185397_9	697282.Mettu_4265	1.967e-30	123.0	COG3360@1|root,COG3360@2|Bacteria,1N6UT@1224|Proteobacteria,1SCF7@1236|Gammaproteobacteria,1XFQV@135618|Methylococcales	135618|Methylococcales	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
TH1_k127_9185397_2	697282.Mettu_3575	2.105e-124	409.0	2B1NE@1|root,31U3X@2|Bacteria,1QJJ9@1224|Proteobacteria,1THJK@1236|Gammaproteobacteria,1XEJ9@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_9185397_7	697282.Mettu_3576	3.75e-57	203.0	COG0537@1|root,COG0537@2|Bacteria,1MZVD@1224|Proteobacteria,1S9D9@1236|Gammaproteobacteria,1XFA7@135618|Methylococcales	135618|Methylococcales	FG	HIT domain	-	-	-	-	-	-	-	-	-	-	-	-	HIT
TH1_k127_9185397_4	857087.Metme_2293	1.875e-102	342.0	COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,1RS0S@1236|Gammaproteobacteria,1XDU4@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine	-	-	2.4.2.44	ko:K19696	ko00270,ko01100,map00270,map01100	-	R09668	RC00063	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
TH1_k127_9185397_6	697282.Mettu_3579	2.809e-80	271.0	COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,1RNPQ@1236|Gammaproteobacteria,1XEZR@135618|Methylococcales	135618|Methylococcales	F	Phosphoribosyl transferase domain	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
TH1_k127_9185397_0	697282.Mettu_3578	1.686e-137	444.0	COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,1RMQF@1236|Gammaproteobacteria,1XEAX@135618|Methylococcales	135618|Methylococcales	M	Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides	nagZ	GO:0003674,GO:0003824,GO:0004553,GO:0004563,GO:0008150,GO:0009273,GO:0009987,GO:0015929,GO:0016787,GO:0016798,GO:0042546,GO:0044085,GO:0071554,GO:0071840	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
TH1_k127_9185397_8	857087.Metme_2385	1.1e-44	164.0	COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,1RNHQ@1236|Gammaproteobacteria,1XE5E@135618|Methylococcales	135618|Methylococcales	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	dnaQ	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
TH1_k127_9186299_3	740709.A10D4_03530	2.562e-35	138.0	COG0386@1|root,COG0386@2|Bacteria,1RDR8@1224|Proteobacteria,1S3WV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Belongs to the glutathione peroxidase family	gpwA	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
TH1_k127_9186299_4	247639.MGP2080_10748	1.48e-09	63.0	COG0386@1|root,COG0386@2|Bacteria,1RDR8@1224|Proteobacteria,1S3WV@1236|Gammaproteobacteria,1J68M@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Belongs to the glutathione peroxidase family	gpwA	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
TH1_k127_9186299_1	1116472.MGMO_80c00010	5.217e-99	327.0	COG0657@1|root,COG0657@2|Bacteria,1N2XW@1224|Proteobacteria,1RRAQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	esterase lipase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Peptidase_S9
TH1_k127_9186299_5	946483.Cenrod_1273	1.22e-05	48.0	COG2189@1|root,COG2189@2|Bacteria,1MX9M@1224|Proteobacteria,2VGZB@28216|Betaproteobacteria,4ACRT@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM DNA methylase N-4 N-6	-	-	2.1.1.72	ko:K07316	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
TH1_k127_9186299_2	261292.Nit79A3_0155	4.587e-64	222.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2WADG@28216|Betaproteobacteria,374FC@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF772
TH1_k127_9186299_0	686340.Metal_2557	0.0	1050.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1XDK9@135618|Methylococcales	135618|Methylococcales	L	TIGRFAM RNA helicase, ATP-dependent DEAH box, HrpA type	-	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DUF3418,HA2,Helicase_C,OB_NTP_bind
TH1_k127_9195969_12	686340.Metal_2638	1.567e-75	272.0	COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,1RMM5@1236|Gammaproteobacteria,1XEBN@135618|Methylococcales	135618|Methylococcales	NU	COG3170 Tfp pilus assembly protein FimV	-	-	-	ko:K08086	-	-	-	-	ko00000	-	-	-	-
TH1_k127_9195969_4	686340.Metal_2639	3.882e-193	605.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RNB6@1236|Gammaproteobacteria,1XDRT@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
TH1_k127_9195969_8	857087.Metme_4021	3.155e-117	381.0	COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,1RNMK@1236|Gammaproteobacteria,1XEGX@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
TH1_k127_9195969_1	686340.Metal_2641	1.533e-250	781.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,1RMF6@1236|Gammaproteobacteria,1XEMR@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
TH1_k127_9195969_11	697282.Mettu_0091	1.191e-101	334.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,1RMT6@1236|Gammaproteobacteria,1XEGI@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
TH1_k127_9195969_13	697282.Mettu_0090	8.022e-66	228.0	COG0517@1|root,COG0517@2|Bacteria,1N0EB@1224|Proteobacteria,1SYB8@1236|Gammaproteobacteria,1XGD2@135618|Methylococcales	135618|Methylococcales	S	PFAM Cystathionine beta-synthase, core	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	CBS
TH1_k127_9195969_18	1120963.KB894491_gene1107	5.201e-07	52.0	2DE24@1|root,2ZK69@2|Bacteria,1P9N5@1224|Proteobacteria,1SU0Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_9195969_10	572477.Alvin_1423	2.397e-106	359.0	COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,1RNZE@1236|Gammaproteobacteria,1WWKF@135613|Chromatiales	135613|Chromatiales	O	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
TH1_k127_9195969_9	1116472.MGMO_105c00470	5.461e-114	370.0	COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,1RNR6@1236|Gammaproteobacteria,1XE0A@135618|Methylococcales	135618|Methylococcales	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
TH1_k127_9195969_3	697282.Mettu_3874	1.095e-229	715.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,1RN9N@1236|Gammaproteobacteria,1XDTP@135618|Methylococcales	135618|Methylococcales	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	-	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
TH1_k127_9195969_0	697282.Mettu_3873	0.0	1311.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1XEU2@135618|Methylococcales	135618|Methylococcales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
TH1_k127_9195969_7	697282.Mettu_2812	4.008e-142	459.0	COG5309@1|root,COG5309@2|Bacteria,1QHPS@1224|Proteobacteria,1TFDF@1236|Gammaproteobacteria,1XES1@135618|Methylococcales	135618|Methylococcales	G	glucosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_9195969_16	697282.Mettu_1804	4.098e-25	109.0	COG3027@1|root,COG3027@2|Bacteria,1PDNP@1224|Proteobacteria,1THU0@1236|Gammaproteobacteria,1XFQ1@135618|Methylococcales	135618|Methylococcales	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	-	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
TH1_k127_9195969_17	857087.Metme_0777	1.431e-17	85.0	2AP81@1|root,31E9W@2|Bacteria,1QH87@1224|Proteobacteria,1SX59@1236|Gammaproteobacteria,1XFQ7@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	ko:K09892	-	-	-	-	ko00000,ko03036	-	-	-	-
TH1_k127_9195969_15	857087.Metme_0778	8.845e-50	183.0	COG3079@1|root,COG3079@2|Bacteria,1N7W0@1224|Proteobacteria,1SCPW@1236|Gammaproteobacteria,1XFDI@135618|Methylococcales	135618|Methylococcales	S	Belongs to the UPF0149 family	-	-	-	ko:K09895	-	-	-	-	ko00000	-	-	-	UPF0149
TH1_k127_9195969_2	1116472.MGMO_85c00090	2.175e-230	718.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1XE0U@135618|Methylococcales	135618|Methylococcales	E	Belongs to the peptidase M24B family	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
TH1_k127_9195969_6	686340.Metal_3670	1.504e-157	506.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RMS3@1236|Gammaproteobacteria,1XEIS@135618|Methylococcales	135618|Methylococcales	CH	Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6	ubiH	-	-	ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
TH1_k127_9195969_5	697282.Mettu_1809	1.774e-162	522.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RND5@1236|Gammaproteobacteria,1XG35@135618|Methylococcales	135618|Methylococcales	CH	TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
TH1_k127_9195969_14	1116472.MGMO_85c00020	7.846e-63	217.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria,1XDUX@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
TH1_k127_9201862_8	686340.Metal_1071	1.163e-12	68.0	COG0373@1|root,COG0373@2|Bacteria,1MXX5@1224|Proteobacteria,1T532@1236|Gammaproteobacteria,1XH1B@135618|Methylococcales	135618|Methylococcales	H	PFAM Methylene-tetrahydromethanopterin dehydrogenase, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Mpt_N
TH1_k127_9201862_3	686340.Metal_1070	8.765e-149	475.0	COG0373@1|root,COG0373@2|Bacteria,1MXX5@1224|Proteobacteria,1S03H@1236|Gammaproteobacteria,1XDMW@135618|Methylococcales	135618|Methylococcales	H	PFAM Methylene-tetrahydromethanopterin dehydrogenase, N-terminal	-	-	-	ko:K10714	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R08059	RC00202	ko00000,ko00001,ko01000	-	-	-	Mpt_N
TH1_k127_9201862_2	686340.Metal_3902	1.039e-173	550.0	COG0473@1|root,COG0473@2|Bacteria,1QU2H@1224|Proteobacteria,1T1N6@1236|Gammaproteobacteria,1XEN9@135618|Methylococcales	135618|Methylococcales	C	PFAM Isocitrate isopropylmalate dehydrogenase	-	-	1.1.1.41	ko:K00030	ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00709	RC00114	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TH1_k127_9201862_4	697282.Mettu_4361	1.167e-140	453.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,1RPRD@1236|Gammaproteobacteria,1XEDZ@135618|Methylococcales	135618|Methylococcales	C	alcohol dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N_2
TH1_k127_9201862_6	857087.Metme_2002	1.474e-55	201.0	COG3531@1|root,COG3531@2|Bacteria,1RIN9@1224|Proteobacteria,1RS8P@1236|Gammaproteobacteria,1XGG0@135618|Methylococcales	135618|Methylococcales	O	Thioredoxin	-	-	-	ko:K07396	-	-	-	-	ko00000	-	-	-	Thioredoxin_5
TH1_k127_9201862_7	686340.Metal_2562	4.617e-13	76.0	2AW8C@1|root,31N3M@2|Bacteria,1QJV5@1224|Proteobacteria,1THWR@1236|Gammaproteobacteria,1XFWB@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_9201862_5	243233.MCA0343	5.238e-101	334.0	COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,1S22I@1236|Gammaproteobacteria,1XE9Z@135618|Methylococcales	135618|Methylococcales	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	gloB	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	HAGH_C,Lactamase_B
TH1_k127_9201862_0	391165.GbCGDNIH1_0121	1.474e-304	979.0	COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,2TR45@28211|Alphaproteobacteria,2JQWJ@204441|Rhodospirillales	204441|Rhodospirillales	S	TamB, inner membrane protein subunit of TAM complex	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
TH1_k127_9201862_1	391165.GbCGDNIH1_0120	6.51e-177	573.0	COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,2TRWD@28211|Alphaproteobacteria,2JPPU@204441|Rhodospirillales	204441|Rhodospirillales	M	Surface antigen	-	-	-	ko:K07278	-	-	-	-	ko00000,ko02000	1.B.33.2.4	-	-	Bac_surface_Ag,POTRA
TH1_k127_9217385_4	1121403.AUCV01000033_gene3653	4.389e-05	46.0	COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,42NFH@68525|delta/epsilon subdivisions,2WITT@28221|Deltaproteobacteria,2MHQE@213118|Desulfobacterales	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TH1_k127_9217385_1	1131266.ARWQ01000001_gene1238	3.393e-89	304.0	arCOG08055@1|root,arCOG08055@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TH1_k127_9217385_2	857087.Metme_0194	1.58e-71	247.0	COG0500@1|root,COG2226@2|Bacteria,1MYPU@1224|Proteobacteria,1SZ13@1236|Gammaproteobacteria,1XE4M@135618|Methylococcales	135618|Methylococcales	H	PFAM Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TH1_k127_9217385_3	857087.Metme_0663	1.363e-31	124.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,1XFQ2@135618|Methylococcales	135618|Methylococcales	K	SMART Cold shock protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TH1_k127_9217385_0	211165.AJLN01000093_gene1049	0.0	1135.0	COG0058@1|root,COG0058@2|Bacteria,1FZUX@1117|Cyanobacteria,1JKQ6@1189|Stigonemataceae	1117|Cyanobacteria	G	Carbohydrate phosphorylase	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
TH1_k127_9222035_1	765911.Thivi_3657	0.0	1206.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1WVYX@135613|Chromatiales	1236|Gammaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
TH1_k127_9222035_6	1116472.MGMO_49c00040	9.179e-104	340.0	COG0406@1|root,COG0406@2|Bacteria,1RHAT@1224|Proteobacteria,1SAR4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Phosphoglycerate mutase	-	-	3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
TH1_k127_9222035_2	909663.KI867150_gene2888	1.128e-292	913.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,42P3J@68525|delta/epsilon subdivisions,2WKFS@28221|Deltaproteobacteria,2MQ9F@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
TH1_k127_9222035_5	472759.Nhal_3094	1.592e-132	435.0	COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,1RMKB@1236|Gammaproteobacteria,1WWEE@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
TH1_k127_9222035_0	338966.Ppro_0406	0.0	1667.0	COG3408@1|root,COG3408@2|Bacteria,1QUN2@1224|Proteobacteria,42PYS@68525|delta/epsilon subdivisions,2WMEG@28221|Deltaproteobacteria,43UGD@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
TH1_k127_9222035_3	118173.KB235914_gene1802	3.991e-275	851.0	COG0366@1|root,COG0366@2|Bacteria,1G35V@1117|Cyanobacteria,1H9Z8@1150|Oscillatoriales	1117|Cyanobacteria	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
TH1_k127_9222035_7	338966.Ppro_0408	6.073e-78	273.0	29MQ2@1|root,308MT@2|Bacteria,1REUR@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_9222035_4	686340.Metal_2120	6.268e-156	504.0	28MV6@1|root,2ZB2T@2|Bacteria,1R710@1224|Proteobacteria,1SMZR@1236|Gammaproteobacteria,1XEVI@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_9240284_2	870187.Thini_3420	8.654e-73	250.0	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,1RMWC@1236|Gammaproteobacteria,460F5@72273|Thiotrichales	72273|Thiotrichales	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
TH1_k127_9240284_3	697282.Mettu_1258	8.171e-61	214.0	COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,1RNJ2@1236|Gammaproteobacteria,1XFCM@135618|Methylococcales	135618|Methylococcales	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
TH1_k127_9240284_4	1116472.MGMO_5c00120	8.012e-38	142.0	COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,1S8RT@1236|Gammaproteobacteria,1XFK5@135618|Methylococcales	135618|Methylococcales	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
TH1_k127_9240284_0	1116472.MGMO_2c00060	3.618e-184	586.0	COG3206@1|root,COG3206@2|Bacteria,1QJKV@1224|Proteobacteria,1THMG@1236|Gammaproteobacteria,1XEV1@135618|Methylococcales	135618|Methylococcales	M	protein involved in exopolysaccharide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_9240284_1	1116472.MGMO_2c00070	3.198e-127	419.0	COG4942@1|root,COG4942@2|Bacteria,1R1HI@1224|Proteobacteria,1T53G@1236|Gammaproteobacteria,1XH1F@135618|Methylococcales	135618|Methylococcales	D	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_9258218_0	697282.Mettu_1233	4.627e-95	315.0	COG0600@1|root,COG0600@2|Bacteria,1MWS0@1224|Proteobacteria,1RR15@1236|Gammaproteobacteria,1XEC4@135618|Methylococcales	135618|Methylococcales	P	PFAM Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
TH1_k127_9258218_1	697282.Mettu_1232	1.448e-76	261.0	COG0715@1|root,COG0715@2|Bacteria,1MWUA@1224|Proteobacteria,1S2B3@1236|Gammaproteobacteria,1XDIW@135618|Methylococcales	135618|Methylococcales	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
TH1_k127_9266894_3	697282.Mettu_1233	3.308e-44	161.0	COG0600@1|root,COG0600@2|Bacteria,1MWS0@1224|Proteobacteria,1RR15@1236|Gammaproteobacteria,1XEC4@135618|Methylococcales	135618|Methylococcales	P	PFAM Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
TH1_k127_9266894_1	697282.Mettu_1234	4.61e-99	330.0	COG1116@1|root,COG1116@2|Bacteria,1MU6C@1224|Proteobacteria,1SZ7W@1236|Gammaproteobacteria,1XEMA@135618|Methylococcales	135618|Methylococcales	P	ABC transporter	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
TH1_k127_9266894_5	686340.Metal_3416	6.376e-12	71.0	2994J@1|root,31N33@2|Bacteria,1QJUJ@1224|Proteobacteria,1THW2@1236|Gammaproteobacteria,1XFV3@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_9266894_4	243233.MCA1029	6.922e-15	82.0	28UGB@1|root,2ZGM6@2|Bacteria,1P6GP@1224|Proteobacteria,1STQN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_9266894_2	768671.ThimaDRAFT_4174	4.191e-66	231.0	COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,1S6FG@1236|Gammaproteobacteria,1WY34@135613|Chromatiales	135613|Chromatiales	S	pfam ammecr1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
TH1_k127_9266894_0	857087.Metme_2908	6.031e-101	332.0	COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,1RQPK@1236|Gammaproteobacteria,1XEER@135618|Methylococcales	135618|Methylococcales	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
TH1_k127_9275596_2	195250.CM001776_gene307	0.0004566	43.0	COG0225@1|root,COG0225@2|Bacteria,1G1QF@1117|Cyanobacteria,1GYT4@1129|Synechococcus	1117|Cyanobacteria	C	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
TH1_k127_9275596_0	697282.Mettu_0443	0.0	1334.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1XEDV@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
TH1_k127_9275596_1	697282.Mettu_2985	4.886e-160	508.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1XG74@135618|Methylococcales	135618|Methylococcales	P	Cation transporter/ATPase, N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
TH1_k127_9287332_0	1454004.AW11_03130	2.427e-221	696.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2VHIG@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	rve
TH1_k127_9289485_0	686340.Metal_3548	3.221e-101	333.0	COG1948@1|root,COG1948@2|Bacteria,1RI2C@1224|Proteobacteria,1S8PK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	PFAM ERCC4 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ERCC4,HHH_2,HHH_5
TH1_k127_9289485_2	543632.JOJL01000015_gene8675	1.185e-19	93.0	COG1716@1|root,COG1716@2|Bacteria,2GYXM@201174|Actinobacteria,4DKJD@85008|Micromonosporales	201174|Actinobacteria	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
TH1_k127_9289485_1	1463934.JOCF01000096_gene1779	6.644e-26	112.0	COG0631@1|root,COG0631@2|Bacteria,2GMNH@201174|Actinobacteria	201174|Actinobacteria	T	Serine/threonine phosphatases, family 2C, catalytic domain	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
TH1_k127_9307345_0	697282.Mettu_0631	7.054e-174	548.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1XDXS@135618|Methylococcales	135618|Methylococcales	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
TH1_k127_9307345_1	857087.Metme_4451	8.596e-46	172.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RNPT@1236|Gammaproteobacteria,1XEAK@135618|Methylococcales	135618|Methylococcales	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TH1_k127_9320764_5	857087.Metme_3420	1.182e-38	146.0	2C3QV@1|root,2Z7YP@2|Bacteria,1MXAM@1224|Proteobacteria,1RNIA@1236|Gammaproteobacteria,1XEFQ@135618|Methylococcales	135618|Methylococcales	S	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
TH1_k127_9320764_0	946483.Cenrod_2337	9.608e-152	501.0	COG0784@1|root,COG2198@1|root,COG2200@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2200@2|Bacteria,1NC9X@1224|Proteobacteria,2WGSU@28216|Betaproteobacteria,4ADPW@80864|Comamonadaceae	28216|Betaproteobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	EAL,Response_reg
TH1_k127_9320764_4	864051.BurJ1DRAFT_4640	1.442e-47	177.0	COG0745@1|root,COG0745@2|Bacteria,1QWG0@1224|Proteobacteria,2WGYI@28216|Betaproteobacteria,1KPDN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	KT	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,Response_reg
TH1_k127_9320764_2	697282.Mettu_2132	1.116e-56	199.0	COG2346@1|root,COG2346@2|Bacteria,1QBDE@1224|Proteobacteria,1S9FC@1236|Gammaproteobacteria,1XFBT@135618|Methylococcales	135618|Methylococcales	C	Group 1 truncated hemoglobin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
TH1_k127_9320764_1	697282.Mettu_2465	6.91e-68	236.0	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,1S41D@1236|Gammaproteobacteria,1XEYD@135618|Methylococcales	135618|Methylococcales	D	Maf-like protein	-	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
TH1_k127_9320764_3	697282.Mettu_2464	3.14e-54	192.0	COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,1S1ZY@1236|Gammaproteobacteria,1XF3V@135618|Methylococcales	135618|Methylococcales	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
TH1_k127_937575_4	1283300.ATXB01000001_gene335	2.234e-56	203.0	COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,1S4M3@1236|Gammaproteobacteria,1XDIX@135618|Methylococcales	135618|Methylococcales	E	PFAM Bacterial extracellular solute-binding	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
TH1_k127_937575_2	686340.Metal_0528	3.021e-135	434.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,1RNMW@1236|Gammaproteobacteria,1XDVR@135618|Methylococcales	135618|Methylococcales	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TH1_k127_937575_1	697282.Mettu_1021	2.67e-208	653.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,1RMAY@1236|Gammaproteobacteria,1XEVP@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TH1_k127_937575_3	857087.Metme_1613	9.258e-70	241.0	COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,1RP00@1236|Gammaproteobacteria,1XF1C@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
TH1_k127_937575_5	857087.Metme_1614	1.088e-37	145.0	COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,1S8W3@1236|Gammaproteobacteria,1XFDN@135618|Methylococcales	135618|Methylococcales	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
TH1_k127_937575_6	857087.Metme_0482	1.959e-34	136.0	COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,1S9P2@1236|Gammaproteobacteria,1XGYG@135618|Methylococcales	135618|Methylococcales	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	-	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1
TH1_k127_937575_0	697282.Mettu_1042	4.747e-267	832.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,1XEGN@135618|Methylococcales	135618|Methylococcales	L	DHH family	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
TH1_k127_937575_7	243233.MCA0596	3.218e-28	114.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,1THGR@1236|Gammaproteobacteria,1XDV9@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TH1_k127_9384485_2	697282.Mettu_2801	3.165e-72	249.0	COG1846@1|root,COG1846@2|Bacteria,1MZS9@1224|Proteobacteria,1SBPM@1236|Gammaproteobacteria,1XEZD@135618|Methylococcales	135618|Methylococcales	K	PFAM HTH transcriptional regulator, MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
TH1_k127_9384485_1	697282.Mettu_3878	1.581e-98	329.0	COG0731@1|root,COG0731@2|Bacteria,1QDZ2@1224|Proteobacteria,1RYS3@1236|Gammaproteobacteria,1XDY3@135618|Methylococcales	135618|Methylococcales	C	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TH1_k127_9384485_0	697282.Mettu_1183	3.742e-201	633.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XDX4@135618|Methylococcales	135618|Methylococcales	T	Nitrogen regulation	-	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH1_k127_939509_0	697282.Mettu_2188	9.765e-285	891.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1XDRC@135618|Methylococcales	135618|Methylococcales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
TH1_k127_939509_1	314345.SPV1_05874	5.113e-27	113.0	COG0252@1|root,COG0252@2|Bacteria,1RHAW@1224|Proteobacteria	1224|Proteobacteria	EJ	GlutRNAGln amidotransferase subunit D	aspG	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
TH1_k127_9407075_4	857087.Metme_0661	7.188e-10	60.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,1S3PD@1236|Gammaproteobacteria,1XFB7@135618|Methylococcales	135618|Methylococcales	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
TH1_k127_9407075_2	697282.Mettu_0300	4.469e-44	164.0	COG3151@1|root,COG3151@2|Bacteria,1QJNF@1224|Proteobacteria,1THP7@1236|Gammaproteobacteria,1XF5H@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF1249)	-	-	-	ko:K09920	-	-	-	-	ko00000	-	-	-	DUF1249
TH1_k127_9407075_1	1116472.MGMO_66c00630	7.019e-63	218.0	COG0720@1|root,COG0720@2|Bacteria,1RKBW@1224|Proteobacteria,1S7FX@1236|Gammaproteobacteria,1XF2V@135618|Methylococcales	135618|Methylococcales	H	PFAM 6-pyruvoyl tetrahydropterin	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
TH1_k127_9407075_3	857087.Metme_3182	3.743e-13	73.0	2AUTZ@1|root,31KH1@2|Bacteria,1QIC9@1224|Proteobacteria,1TG6N@1236|Gammaproteobacteria,1XFT8@135618|Methylococcales	135618|Methylococcales	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
TH1_k127_9407075_0	686340.Metal_3811	3.273e-83	280.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,1RNDC@1236|Gammaproteobacteria,1XDR0@135618|Methylococcales	135618|Methylococcales	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
TH1_k127_9419369_1	697282.Mettu_0998	2.709e-67	234.0	COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,1RMCR@1236|Gammaproteobacteria,1XDRN@135618|Methylococcales	135618|Methylococcales	P	PFAM NnrS	-	-	-	ko:K07234	-	-	-	-	ko00000	-	-	-	NnrS
TH1_k127_9419369_0	686340.Metal_3483	2.279e-137	439.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,1RMXZ@1236|Gammaproteobacteria,1XE3G@135618|Methylococcales	135618|Methylococcales	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
TH1_k127_9432288_18	765913.ThidrDRAFT_2519	1.931e-17	83.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1Q7PK@1224|Proteobacteria,1RSF0@1236|Gammaproteobacteria,1WWA3@135613|Chromatiales	135613|Chromatiales	L	PFAM Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_33
TH1_k127_9432288_10	857087.Metme_3511	2.7e-78	263.0	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,1S280@1236|Gammaproteobacteria,1XF2I@135618|Methylococcales	135618|Methylococcales	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
TH1_k127_9432288_13	686340.Metal_0378	5.269e-59	206.0	COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,1S3Q7@1236|Gammaproteobacteria,1XF4R@135618|Methylococcales	135618|Methylococcales	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
TH1_k127_9432288_8	686340.Metal_0377	1.139e-107	354.0	COG1216@1|root,COG1216@2|Bacteria,1R08C@1224|Proteobacteria,1T52X@1236|Gammaproteobacteria,1XE8T@135618|Methylococcales	135618|Methylococcales	S	PFAM Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
TH1_k127_9432288_14	1116472.MGMO_29c00120	3.866e-38	147.0	COG3952@1|root,COG3952@2|Bacteria,1MZ60@1224|Proteobacteria,1S8XM@1236|Gammaproteobacteria,1XFI5@135618|Methylococcales	135618|Methylococcales	S	PFAM Lipid A Biosynthesis N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	LAB_N
TH1_k127_9432288_3	697282.Mettu_3761	6.129e-176	567.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,1S48Z@1236|Gammaproteobacteria,1XEJQ@135618|Methylococcales	135618|Methylococcales	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TH1_k127_9432288_15	697282.Mettu_3950	8.66e-38	146.0	2FJ56@1|root,34AVD@2|Bacteria,1NZQ6@1224|Proteobacteria,1SS7S@1236|Gammaproteobacteria,1XFAN@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_9432288_6	697282.Mettu_1561	1.909e-116	382.0	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,1RSE6@1236|Gammaproteobacteria,1XDUQ@135618|Methylococcales	135618|Methylococcales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
TH1_k127_9432288_4	686340.Metal_3260	1.331e-144	464.0	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,1RN7F@1236|Gammaproteobacteria,1XEJR@135618|Methylococcales	135618|Methylococcales	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TH1_k127_9432288_9	857087.Metme_4424	2.974e-92	309.0	COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,1RNV4@1236|Gammaproteobacteria,1XEWQ@135618|Methylococcales	135618|Methylococcales	S	Belongs to the multicopper oxidase YfiH RL5 family	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
TH1_k127_9432288_11	697282.Mettu_1226	3.376e-70	243.0	COG1905@1|root,COG1905@2|Bacteria,1RHBU@1224|Proteobacteria,1T09A@1236|Gammaproteobacteria,1XF7D@135618|Methylococcales	135618|Methylococcales	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	2Fe-2S_thioredx
TH1_k127_9432288_2	686340.Metal_1452	6.652e-276	854.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1XEDW@135618|Methylococcales	135618|Methylococcales	C	NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding	-	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
TH1_k127_9432288_0	697282.Mettu_1228	0.0	1672.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,1T1JA@1236|Gammaproteobacteria,1XEFY@135618|Methylococcales	135618|Methylococcales	C	Formate dehydrogenase, alpha subunit	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_6,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
TH1_k127_9432288_7	697282.Mettu_1229	8.038e-109	361.0	COG1526@1|root,COG1526@2|Bacteria,1NRU0@1224|Proteobacteria,1RNFH@1236|Gammaproteobacteria,1XDUR@135618|Methylococcales	135618|Methylococcales	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
TH1_k127_9432288_17	697282.Mettu_1230	2.805e-21	94.0	2E4CR@1|root,32Z86@2|Bacteria,1NJVT@1224|Proteobacteria,1SFKZ@1236|Gammaproteobacteria,1XFQP@135618|Methylococcales	135618|Methylococcales	C	NADH-dependant formate dehydrogenase delta subunit FdsD	-	-	1.17.1.9	ko:K00126	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	FdsD
TH1_k127_9432288_5	697282.Mettu_1558	2.78e-118	385.0	COG0428@1|root,COG0428@2|Bacteria,1R40E@1224|Proteobacteria,1RRYS@1236|Gammaproteobacteria,1XDSY@135618|Methylococcales	135618|Methylococcales	P	ZIP Zinc transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_9432288_1	686340.Metal_3257	5.284e-280	867.0	COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,1RPDV@1236|Gammaproteobacteria,1XEJK@135618|Methylococcales	135618|Methylococcales	G	alpha beta alpha domain I	pgm	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TH1_k127_9432288_12	1116472.MGMO_105c00280	2.228e-64	225.0	COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,1S8WW@1236|Gammaproteobacteria,1XEZJ@135618|Methylococcales	135618|Methylococcales	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
TH1_k127_9432288_16	697282.Mettu_1555	1.34e-21	96.0	2EFUG@1|root,339KM@2|Bacteria,1NGQQ@1224|Proteobacteria,1SHZI@1236|Gammaproteobacteria,1XFQZ@135618|Methylococcales	135618|Methylococcales	S	Alanine-zipper, major outer membrane lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	Alanine_zipper
TH1_k127_9464986_1	323848.Nmul_A1679	1.335e-148	479.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2VJA1@28216|Betaproteobacteria,372T6@32003|Nitrosomonadales	28216|Betaproteobacteria	C	PFAM Multicopper oxidase, type	sufI	-	1.3.3.5	ko:K04753,ko:K08100,ko:K14588	ko00860,ko01110,map00860,map01110	-	R02394	RC01983	ko00000,ko00001,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
TH1_k127_9464986_6	686340.Metal_2659	4.907e-40	153.0	2EBZ4@1|root,335YD@2|Bacteria,1NNWD@1224|Proteobacteria,1SJ3V@1236|Gammaproteobacteria,1XFPK@135618|Methylococcales	135618|Methylococcales	S	Stress responsive A/B Barrel Domain	-	-	-	-	-	-	-	-	-	-	-	-	Dabb
TH1_k127_9464986_4	697282.Mettu_0330	3.025e-95	318.0	COG1357@1|root,COG1357@2|Bacteria,1N7U9@1224|Proteobacteria,1RYAA@1236|Gammaproteobacteria,1XEVU@135618|Methylococcales	135618|Methylococcales	S	Pentapeptide repeats (9 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
TH1_k127_9464986_0	264462.Bd3723	4.341e-212	665.0	COG0538@1|root,COG0538@2|Bacteria,1MUIB@1224|Proteobacteria,42QF2@68525|delta/epsilon subdivisions,2MTFB@213481|Bdellovibrionales,2WMHR@28221|Deltaproteobacteria	213481|Bdellovibrionales	C	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TH1_k127_9464986_2	697282.Mettu_4276	4.129e-143	464.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,1RN0E@1236|Gammaproteobacteria,1XETT@135618|Methylococcales	135618|Methylococcales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
TH1_k127_9464986_3	697282.Mettu_4275	2.117e-99	328.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,1XDVV@135618|Methylococcales	135618|Methylococcales	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TH1_k127_9464986_7	697282.Mettu_1609	4.803e-19	89.0	COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,1RMJU@1236|Gammaproteobacteria,1XE1S@135618|Methylococcales	135618|Methylococcales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.5.1.33	ko:K03793	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
TH1_k127_9586564_0	857087.Metme_2830	0.0	1834.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1XEG1@135618|Methylococcales	135618|Methylococcales	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
TH1_k127_9586564_6	697282.Mettu_3167	1.414e-36	152.0	COG3317@1|root,COG3317@2|Bacteria,1QJPQ@1224|Proteobacteria,1THQN@1236|Gammaproteobacteria,1XFC9@135618|Methylococcales	135618|Methylococcales	M	NlpB/DapX lipoprotein	-	-	-	ko:K07287	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	Lipoprotein_18
TH1_k127_9586564_3	697282.Mettu_3168	1.263e-150	485.0	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,1RNH9@1236|Gammaproteobacteria,1XDWP@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
TH1_k127_9586564_1	686340.Metal_3152	9.733e-192	604.0	COG0269@1|root,COG0794@1|root,COG0269@2|Bacteria,COG0794@2|Bacteria,1QWE4@1224|Proteobacteria,1RPV5@1236|Gammaproteobacteria,1XDWM@135618|Methylococcales	135618|Methylococcales	GM	Orotidine 5'-phosphate decarboxylase / HUMPS family	-	-	4.1.2.43,5.3.1.27	ko:K13831	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05338,R05339,R09780	RC00377,RC00421,RC00422	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase,SIS
TH1_k127_9586564_5	331678.Cphamn1_1682	1.02e-70	244.0	28P4N@1|root,2ZBZT@2|Bacteria	2|Bacteria	S	Putative inner membrane protein (DUF1819)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1819
TH1_k127_9586564_4	882.DVU_2026	2.32e-99	329.0	28KCG@1|root,2Z9ZE@2|Bacteria,1R8W1@1224|Proteobacteria,430BG@68525|delta/epsilon subdivisions,2WTPG@28221|Deltaproteobacteria,2MFQB@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1788)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1788
TH1_k127_9586564_2	1196835.A458_06320	1.296e-163	518.0	COG1293@1|root,COG1293@2|Bacteria,1QUKW@1224|Proteobacteria,1T3MR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	RNA-binding protein homologous to eukaryotic snRNP	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_9599928_0	697282.Mettu_2829	2.887e-230	715.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,1XDQF@135618|Methylococcales	135618|Methylococcales	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
TH1_k127_9599928_1	686340.Metal_0455	2.788e-43	164.0	COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,1S8XZ@1236|Gammaproteobacteria,1XFCN@135618|Methylococcales	135618|Methylococcales	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himD	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
TH1_k127_9610517_9	243233.MCA0562	5.245e-13	71.0	COG5622@1|root,COG5622@2|Bacteria,1N6XP@1224|Proteobacteria,1SCD9@1236|Gammaproteobacteria,1XFCP@135618|Methylococcales	135618|Methylococcales	N	Protein required for attachment to host cells	-	-	-	-	-	-	-	-	-	-	-	-	Host_attach
TH1_k127_9610517_10	1121374.KB891575_gene876	1.679e-12	80.0	2C2C7@1|root,2Z85G@2|Bacteria,1PD07@1224|Proteobacteria,1RP6G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_9610517_5	857087.Metme_1742	4.624e-68	237.0	COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,1S3PX@1236|Gammaproteobacteria,1XF74@135618|Methylococcales	135618|Methylococcales	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
TH1_k127_9610517_6	697282.Mettu_2635	5.582e-55	196.0	COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,1S3YP@1236|Gammaproteobacteria,1XF4V@135618|Methylococcales	135618|Methylococcales	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
TH1_k127_9610517_0	697282.Mettu_2634	3.888e-255	790.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1RMNB@1236|Gammaproteobacteria,1XEJ4@135618|Methylococcales	135618|Methylococcales	I	acetyl-CoA carboxylase, biotin carboxylase	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
TH1_k127_9610517_2	686340.Metal_0058	3.241e-119	390.0	COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,1RNAR@1236|Gammaproteobacteria,1XDJ3@135618|Methylococcales	135618|Methylococcales	J	Methylates ribosomal protein L11	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
TH1_k127_9610517_7	686340.Metal_0057	1.609e-43	166.0	COG1273@1|root,COG1273@2|Bacteria,1MWCU@1224|Proteobacteria,1S892@1236|Gammaproteobacteria,1XGZP@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF3426)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3426
TH1_k127_9610517_1	686340.Metal_0056	1.095e-182	580.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,1RN7Z@1236|Gammaproteobacteria,1XERD@135618|Methylococcales	135618|Methylococcales	J	S-adenosylmethionine-dependent methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
TH1_k127_9610517_8	1120936.KB907216_gene3914	2.39e-40	161.0	COG1376@1|root,COG3409@1|root,COG1376@2|Bacteria,COG3409@2|Bacteria,2GXGF@201174|Actinobacteria,4EGC3@85012|Streptosporangiales	201174|Actinobacteria	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,YkuD
TH1_k127_9610517_3	686340.Metal_2175	1.879e-101	334.0	COG3108@1|root,COG3108@2|Bacteria,1MWW2@1224|Proteobacteria,1RS5K@1236|Gammaproteobacteria,1XF6A@135618|Methylococcales	135618|Methylococcales	S	Bacterial protein of unknown function (DUF882)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_2
TH1_k127_9610517_4	1183438.GKIL_2340	3.357e-79	275.0	COG1376@1|root,COG1376@2|Bacteria,1G4ZS@1117|Cyanobacteria	1117|Cyanobacteria	S	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
TH1_k127_9629938_1	697282.Mettu_3151	6.871e-125	406.0	COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,1RNRZ@1236|Gammaproteobacteria,1XE55@135618|Methylococcales	135618|Methylococcales	K	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair	rapA	-	-	ko:K03580	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Helicase_C,RapA_C,SNF2_N
TH1_k127_9629938_0	1116472.MGMO_56c00040	1.892e-234	730.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,1RPNP@1236|Gammaproteobacteria,1XG1Z@135618|Methylococcales	135618|Methylococcales	P	Chromate transporter	-	-	-	-	-	-	-	-	-	-	-	-	Chromate_transp
TH1_k127_9629938_2	697282.Mettu_3968	1.454e-75	258.0	COG3658@1|root,COG3658@2|Bacteria,1RIG7@1224|Proteobacteria,1S4KI@1236|Gammaproteobacteria,1XFME@135618|Methylococcales	135618|Methylococcales	C	Cytochrome b/b6/petB	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
TH1_k127_9637067_3	697282.Mettu_0043	5.952e-56	197.0	COG0684@1|root,COG0684@2|Bacteria,1RH18@1224|Proteobacteria,1RS9U@1236|Gammaproteobacteria,1XFEJ@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions	-	-	-	ko:K02553	-	-	-	-	ko00000,ko03019	-	-	-	RraA-like
TH1_k127_9637067_1	686340.Metal_1692	9.13e-165	522.0	COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,1RMN8@1236|Gammaproteobacteria,1XEJA@135618|Methylococcales	135618|Methylococcales	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
TH1_k127_9637067_7	243233.MCA2340	1.835e-24	102.0	COG0267@1|root,COG0267@2|Bacteria,1N6QV@1224|Proteobacteria,1SCEJ@1236|Gammaproteobacteria,1XFR0@135618|Methylococcales	135618|Methylococcales	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
TH1_k127_9637067_4	686340.Metal_1194	1.895e-41	153.0	COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,1S8UG@1236|Gammaproteobacteria,1XFJ2@135618|Methylococcales	135618|Methylococcales	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
TH1_k127_9637067_0	697282.Mettu_0419	0.0	1148.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria,1XDZ8@135618|Methylococcales	135618|Methylococcales	G	TIGRFAM PQQ-dependent dehydrogenase, methanol ethanol family	-	-	-	-	-	-	-	-	-	-	-	-	PQQ
TH1_k127_9637067_5	1283300.ATXB01000001_gene1041	2.161e-40	161.0	2BFY8@1|root,329TX@2|Bacteria,1R582@1224|Proteobacteria,1S61M@1236|Gammaproteobacteria,1XGEV@135618|Methylococcales	135618|Methylococcales	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_9637067_2	857087.Metme_3252	2.574e-83	282.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,1RSHC@1236|Gammaproteobacteria,1XEJZ@135618|Methylococcales	135618|Methylococcales	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
TH1_k127_9637067_6	1116472.MGMO_64c00100	6.34e-30	122.0	2EV48@1|root,33NJ5@2|Bacteria,1NKHY@1224|Proteobacteria,1SJAZ@1236|Gammaproteobacteria,1XFGN@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_9637067_8	1101190.ARWB01000001_gene1459	0.0001479	46.0	2DRX1@1|root,33DGC@2|Bacteria,1NBK0@1224|Proteobacteria,2UIFZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_96950_1	857087.Metme_4332	2.897e-20	91.0	COG2730@1|root,COG2730@2|Bacteria,1RGQH@1224|Proteobacteria,1SZG0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Cellulase (glycosyl hydrolase family 5)	-	-	3.2.1.58	ko:K01210	ko00500,map00500	-	R00308,R03115	RC00467	ko00000,ko00001,ko01000	-	-	-	Cellulase
TH1_k127_96950_0	857087.Metme_2615	0.0	1199.0	COG1966@1|root,COG1966@2|Bacteria,1MWF9@1224|Proteobacteria,1RMG4@1236|Gammaproteobacteria,1XDRS@135618|Methylococcales	135618|Methylococcales	T	Carbon starvation protein CstA	-	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
TH1_k127_9697082_0	686340.Metal_3723	7.596e-188	597.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1XEQ5@135618|Methylococcales	135618|Methylococcales	H	Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C
TH1_k127_9697082_2	697282.Mettu_2455	2.518e-14	75.0	2AUW6@1|root,31KJM@2|Bacteria,1QIEW@1224|Proteobacteria,1TG99@1236|Gammaproteobacteria,1XFWQ@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_9697082_1	697282.Mettu_2454	1.876e-54	195.0	COG1714@1|root,COG1714@2|Bacteria,1N4N8@1224|Proteobacteria,1S9C5@1236|Gammaproteobacteria,1XFBI@135618|Methylococcales	135618|Methylococcales	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
TH1_k127_9706367_6	243233.MCA0043	9.24e-80	267.0	COG0698@1|root,COG0698@2|Bacteria,1RHBF@1224|Proteobacteria,1S3FD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Ribose 5-phosphate isomerase	rpiB	GO:0003674,GO:0003824,GO:0004751,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0008786,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019313,GO:0019314,GO:0019316,GO:0019318,GO:0019320,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0046367,GO:0071704,GO:1901575	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	iECABU_c1320.ECABU_c46440,ic_1306.c5096	LacAB_rpiB
TH1_k127_9706367_7	243233.MCA0042	5.239e-79	267.0	COG0678@1|root,COG0678@2|Bacteria,1MU0H@1224|Proteobacteria,1RRFB@1236|Gammaproteobacteria,1XDU3@135618|Methylococcales	135618|Methylococcales	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	Redoxin
TH1_k127_9706367_1	697282.Mettu_3759	7.304e-175	553.0	COG0673@1|root,COG0673@2|Bacteria,1MZIG@1224|Proteobacteria,1RS5T@1236|Gammaproteobacteria,1XEQF@135618|Methylococcales	135618|Methylococcales	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TH1_k127_9706367_8	686340.Metal_3154	1.946e-30	120.0	COG1773@1|root,COG1773@2|Bacteria,1QJU0@1224|Proteobacteria,1THVE@1236|Gammaproteobacteria,1XFTX@135618|Methylococcales	135618|Methylococcales	C	Rubredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
TH1_k127_9706367_0	697282.Mettu_2069	1.003e-175	560.0	COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,1RQEI@1236|Gammaproteobacteria,1XDYI@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	-	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
TH1_k127_9706367_5	697282.Mettu_2070	6.887e-80	269.0	COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,1S3VN@1236|Gammaproteobacteria,1XF1U@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
TH1_k127_9706367_2	1444770.AF72_05930	2.278e-91	306.0	COG1028@1|root,COG1028@2|Bacteria,1MUPY@1224|Proteobacteria,1RMCB@1236|Gammaproteobacteria,1X4MA@135614|Xanthomonadales	135614|Xanthomonadales	IQ	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TH1_k127_9706367_9	1163617.SCD_n02757	3.538e-29	121.0	COG4706@1|root,COG4706@2|Bacteria,1RIH4@1224|Proteobacteria,2VT0K@28216|Betaproteobacteria	28216|Betaproteobacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	-
TH1_k127_9706367_3	765911.Thivi_2251	3.178e-88	301.0	COG4261@1|root,COG4261@2|Bacteria,1MVXJ@1224|Proteobacteria,1RNKV@1236|Gammaproteobacteria,1WW87@135613|Chromatiales	135613|Chromatiales	S	Bacterial lipid A biosynthesis acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Lip_A_acyltrans
TH1_k127_9706367_10	1234364.AMSF01000030_gene3434	6.313e-15	78.0	COG0764@1|root,COG0764@2|Bacteria,1NGGK@1224|Proteobacteria,1SJ6T@1236|Gammaproteobacteria,1X85H@135614|Xanthomonadales	135614|Xanthomonadales	I	3-hydroxymyristoyl 3-hydroxydecanoyl-(acyl carrier protein)	-	-	-	-	-	-	-	-	-	-	-	-	FabA,PS-DH
TH1_k127_9706367_4	1283300.ATXB01000001_gene445	4.965e-85	299.0	COG0318@1|root,COG0318@2|Bacteria,1MXPB@1224|Proteobacteria,1RRD5@1236|Gammaproteobacteria,1XEQ7@135618|Methylococcales	135618|Methylococcales	IQ	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
TH1_k127_9706367_11	1116472.MGMO_126c00090	3.234e-10	61.0	COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,1T213@1236|Gammaproteobacteria,1XE88@135618|Methylococcales	135618|Methylococcales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
## 2545 queries scanned
## Total time (seconds): 163.58551907539368
## Rate: 15.56 q/s