## Thu Feb 19 17:17:47 2026
## emapper-2.1.13
## /data/anaconda3/envs/eggnog-mapper/bin/emapper.py -i /data/result/bins/wyx/bins/TH2_bin.19.fa -m mmseqs --output TH2_bin.19 --output_dir /data/result/bins/wyx/eggqs50+/TH2_bin.19 --itype genome --cpu 8 --override
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
TH2_k127_1011860_3	589865.DaAHT2_1598	6.361e-38	152.0	2C5Z2@1|root,32U5Z@2|Bacteria,1N4MT@1224|Proteobacteria,42TX0@68525|delta/epsilon subdivisions,2WQZM@28221|Deltaproteobacteria,2MKYF@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF3786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3786
TH2_k127_1011860_5	671143.DAMO_1183	3.856e-26	114.0	COG1669@1|root,COG1669@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	DUF86,NTP_transf_2
TH2_k127_1011860_1	269799.Gmet_2720	4.783e-156	509.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,42QCV@68525|delta/epsilon subdivisions,2WJP8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Peptidase U62 modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
TH2_k127_1011860_4	289376.THEYE_A0655	9.017e-37	145.0	COG0597@1|root,COG0597@2|Bacteria,3J0S2@40117|Nitrospirae	40117|Nitrospirae	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
TH2_k127_1011860_0	289376.THEYE_A0654	0.0	1216.0	COG0060@1|root,COG0060@2|Bacteria,3J0BF@40117|Nitrospirae	40117|Nitrospirae	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
TH2_k127_1011860_2	373903.Hore_07910	1.001e-57	211.0	COG0648@1|root,COG0648@2|Bacteria,1TP1D@1239|Firmicutes,2499E@186801|Clostridia,3WABN@53433|Halanaerobiales	186801|Clostridia	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
TH2_k127_1137498_5	304371.MCP_1347	8.236e-40	154.0	COG0529@1|root,arCOG01040@2157|Archaea,2XU4H@28890|Euryarchaeota,2NBDX@224756|Methanomicrobia	224756|Methanomicrobia	P	Adenylylsulphate kinase	cysC	-	2.7.1.25	ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	M00176	R00509,R04928	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase
TH2_k127_1137498_3	477974.Daud_0416	2.845e-82	278.0	COG1335@1|root,COG1335@2|Bacteria,1V5TQ@1239|Firmicutes,24IZ9@186801|Clostridia,265QG@186807|Peptococcaceae	186801|Clostridia	Q	PFAM Isochorismatase	entB	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
TH2_k127_1137498_0	289376.THEYE_A0687	2.135e-311	971.0	COG0556@1|root,COG0556@2|Bacteria,3J0FS@40117|Nitrospirae	40117|Nitrospirae	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
TH2_k127_1137498_1	289376.THEYE_A1196	2.367e-230	721.0	COG0034@1|root,COG0034@2|Bacteria,3J0C5@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7,Pribosyltran
TH2_k127_1137498_2	289376.THEYE_A1195	6.508e-128	419.0	COG2309@1|root,COG2309@2|Bacteria	2|Bacteria	E	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M29
TH2_k127_1137498_6	1123376.AUIU01000013_gene1907	9.152e-35	136.0	COG1324@1|root,COG1324@2|Bacteria,3J0UM@40117|Nitrospirae	40117|Nitrospirae	P	CutA1 divalent ion tolerance protein	cutA	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
TH2_k127_1137498_4	177437.HRM2_39610	3.513e-80	272.0	COG3449@1|root,COG3449@2|Bacteria,1RF2U@1224|Proteobacteria,42S14@68525|delta/epsilon subdivisions,2WNUI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	SOUL heme-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SOUL
TH2_k127_1137498_7	747365.Thena_1007	1.271e-33	137.0	COG0500@1|root,COG1047@1|root,COG1047@2|Bacteria,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	fkpB	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0061077,GO:0071704,GO:0140096,GO:1901564	5.2.1.8	ko:K03774,ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C,Methyltransf_11
TH2_k127_1142658_4	289376.THEYE_A0246	3.791e-102	340.0	COG0421@1|root,COG0421@2|Bacteria,3J0Y5@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
TH2_k127_1142658_7	1162668.LFE_1513	2.312e-48	177.0	COG1586@1|root,COG1586@2|Bacteria,3J15H@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speH	-	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc
TH2_k127_1142658_1	667014.Thein_1409	0.0	1180.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,2GGWR@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	GT	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
TH2_k127_1142658_2	1123376.AUIU01000002_gene1678	3.92e-177	564.0	COG0057@1|root,COG0057@2|Bacteria,3J0D8@40117|Nitrospirae	40117|Nitrospirae	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	-	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
TH2_k127_1142658_3	289376.THEYE_A1958	2.456e-125	406.0	COG0107@1|root,COG0107@2|Bacteria,3J0GV@40117|Nitrospirae	40117|Nitrospirae	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TH2_k127_1142658_6	289376.THEYE_A1955	1.696e-88	297.0	COG0106@1|root,COG0106@2|Bacteria,3J0KA@40117|Nitrospirae	40117|Nitrospirae	E	Histidine biosynthesis protein	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TH2_k127_1142658_5	748658.KB907313_gene2199	1.179e-92	316.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria,1WWEM@135613|Chromatiales	135613|Chromatiales	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
TH2_k127_1142658_9	1123376.AUIU01000013_gene1877	1.848e-35	139.0	COG0789@1|root,COG0789@2|Bacteria	2|Bacteria	K	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding	hspR	GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
TH2_k127_1142658_0	1123376.AUIU01000013_gene1878	0.0	1268.0	COG0542@1|root,COG0542@2|Bacteria,3J0AV@40117|Nitrospirae	40117|Nitrospirae	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
TH2_k127_1142658_8	1123376.AUIU01000013_gene1879	1.399e-47	175.0	COG0071@1|root,COG0071@2|Bacteria	2|Bacteria	O	Belongs to the small heat shock protein (HSP20) family	hspX	GO:0001666,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009267,GO:0009408,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0009991,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016310,GO:0019538,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0036293,GO:0036294,GO:0040007,GO:0040008,GO:0042221,GO:0042594,GO:0043170,GO:0043207,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045926,GO:0046777,GO:0048519,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0065007,GO:0070482,GO:0070887,GO:0071453,GO:0071456,GO:0071496,GO:0071704,GO:0071944,GO:0075136,GO:1901564	-	ko:K06335,ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
TH2_k127_1142977_6	589865.DaAHT2_2454	1.045e-110	364.0	COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,42Y69@68525|delta/epsilon subdivisions,2WJ5F@28221|Deltaproteobacteria,2MI66@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF_2,HTH_8,Sigma54_activat
TH2_k127_1142977_5	289376.THEYE_A0155	1.527e-132	432.0	COG0337@1|root,COG0337@2|Bacteria,3J0GA@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
TH2_k127_1142977_12	289376.THEYE_A0154	6.52e-44	174.0	COG0703@1|root,COG0703@2|Bacteria,3J0R8@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
TH2_k127_1142977_11	1123376.AUIU01000011_gene1074	8.89e-49	180.0	COG1525@1|root,COG1525@2|Bacteria	2|Bacteria	L	nuclease	nucH	GO:0003674,GO:0003824,GO:0004518,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901361,GO:1901575	3.1.31.1	ko:K01174	-	-	-	-	ko00000,ko01000	-	-	-	Excalibur,SNase
TH2_k127_1142977_18	643562.Daes_3127	2.146e-12	70.0	COG5336@1|root,COG5336@2|Bacteria,1NHIS@1224|Proteobacteria,42WTD@68525|delta/epsilon subdivisions,2WSRU@28221|Deltaproteobacteria,2MDF1@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter	atpZ	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATPase_gene1
TH2_k127_1142977_16	289376.THEYE_A0148	2.283e-30	128.0	COG3381@1|root,COG3381@2|Bacteria	2|Bacteria	S	protein complex oligomerization	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_del
TH2_k127_1142977_17	404380.Gbem_1088	1.136e-26	119.0	COG0723@1|root,COG0723@2|Bacteria,1NINP@1224|Proteobacteria,42X9Z@68525|delta/epsilon subdivisions,2WSPW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Rieske 2Fe-2S	cbcV	-	1.10.9.1	ko:K02636	ko00195,ko01100,map00195,map01100	M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	iAF987.Gmet_1922	CytB6-F_Fe-S,Rieske
TH2_k127_1142977_7	269799.Gmet_1923	2.277e-88	303.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,42MD6@68525|delta/epsilon subdivisions,2WPA2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	cbcW	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_B_N_2,Cytochrom_C,Cytochrome_B,Cytochrome_CBB3
TH2_k127_1142977_9	1121918.ARWE01000001_gene2158	1.569e-57	213.0	COG0484@1|root,COG0484@2|Bacteria,1NR5B@1224|Proteobacteria,42YEQ@68525|delta/epsilon subdivisions,2WTT6@28221|Deltaproteobacteria,43TYC@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1142977_2	1232410.KI421424_gene1758	6.289e-159	510.0	COG5557@1|root,COG5557@2|Bacteria,1PFX4@1224|Proteobacteria,42NUN@68525|delta/epsilon subdivisions,2WJHN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
TH2_k127_1142977_4	1125863.JAFN01000001_gene561	2.472e-133	431.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,43AKQ@68525|delta/epsilon subdivisions,2X60P@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM 4Fe-4S	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_11,Fer4_4
TH2_k127_1142977_10	1232410.KI421424_gene1760	6.578e-54	196.0	COG2010@1|root,COG2010@2|Bacteria,1QYFZ@1224|Proteobacteria,43CC3@68525|delta/epsilon subdivisions,2WQTQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1142977_1	316067.Geob_1017	1.73e-200	631.0	COG4881@1|root,COG4881@2|Bacteria,1QXMX@1224|Proteobacteria,43C41@68525|delta/epsilon subdivisions,2WKYD@28221|Deltaproteobacteria,43TBN@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Polysulphide reductase, NrfD	cbcU	-	-	-	-	-	-	-	-	-	-	-	NrfD
TH2_k127_1142977_3	316067.Geob_1016	7.803e-135	433.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42QZ2@68525|delta/epsilon subdivisions,2WMS4@28221|Deltaproteobacteria,43T2N@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	cbcT	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_11,Fer4_2,Fer4_3,Fer4_7
TH2_k127_1142977_8	269799.Gmet_3518	4.587e-62	217.0	2EE9W@1|root,3384B@2|Bacteria,1NCE1@1224|Proteobacteria,42VUH@68525|delta/epsilon subdivisions,2WSA1@28221|Deltaproteobacteria,43V30@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Menaquinol oxidoreductase complex Cbc4, cytochrome c subunit	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Paired_CXXCH_1
TH2_k127_1142977_15	565033.GACE_0099	3.594e-39	162.0	arCOG06549@1|root,arCOG06549@2157|Archaea,2Y31C@28890|Euryarchaeota,246R3@183980|Archaeoglobi	183980|Archaeoglobi	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
TH2_k127_1142977_0	289376.THEYE_A0147	3.346e-201	635.0	COG0001@1|root,COG0001@2|Bacteria,3J0B3@40117|Nitrospirae	40117|Nitrospirae	H	Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TH2_k127_1142977_13	765911.Thivi_2827	8.776e-44	164.0	COG2050@1|root,COG2050@2|Bacteria,1RH35@1224|Proteobacteria,1S4YC@1236|Gammaproteobacteria,1WYD8@135613|Chromatiales	135613|Chromatiales	Q	PFAM thioesterase superfamily	-	-	-	ko:K02614	ko00360,map00360	-	R09840	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	4HBT
TH2_k127_1142977_14	927677.ALVU02000001_gene1450	3.646e-42	164.0	COG5002@1|root,COG5002@2|Bacteria,1GHEK@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,dCache_1
TH2_k127_1153275_14	243231.GSU2035	2.101e-08	55.0	COG4968@1|root,COG4968@2|Bacteria,1REDT@1224|Proteobacteria,42RY5@68525|delta/epsilon subdivisions,2WNPG@28221|Deltaproteobacteria,43V26@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	Prokaryotic N-terminal methylation motif	pilW-2	-	-	-	-	-	-	-	-	-	-	-	N_methyl,PilW
TH2_k127_1153275_10	398767.Glov_2151	1.107e-38	153.0	2E6Z6@1|root,331IC@2|Bacteria,1NY0D@1224|Proteobacteria,430VK@68525|delta/epsilon subdivisions,2WVKD@28221|Deltaproteobacteria,43VJN@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	pilX-2	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1153275_11	909663.KI867149_gene3436	2.529e-33	142.0	COG3209@1|root,COG3209@2|Bacteria,1PGQF@1224|Proteobacteria,43F38@68525|delta/epsilon subdivisions,2X37N@28221|Deltaproteobacteria,2MSB0@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1153275_3	289376.THEYE_A1020	2.151e-63	232.0	2CB8R@1|root,2Z90U@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1153275_6	518766.Rmar_0625	7.178e-54	199.0	COG1515@1|root,COG1515@2|Bacteria,4NI4J@976|Bacteroidetes,1FK2J@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	L	DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA	nfi	-	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
TH2_k127_1153275_1	243231.GSU1822	2.066e-248	797.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,42MRR@68525|delta/epsilon subdivisions,2WIQ7@28221|Deltaproteobacteria,43TPJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
TH2_k127_1153275_4	289376.THEYE_A0705	7.524e-60	213.0	COG0237@1|root,COG0237@2|Bacteria,3J0RK@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
TH2_k127_1153275_2	1123376.AUIU01000012_gene1334	4.493e-86	297.0	COG0196@1|root,COG0196@2|Bacteria,3J0KY@40117|Nitrospirae	40117|Nitrospirae	H	Riboflavin kinase	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
TH2_k127_1153275_5	686578.AFFX01000008_gene2778	2.547e-59	229.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006276,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010332,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042221,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0046677,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
TH2_k127_1153275_0	289376.THEYE_A0251	0.0	1251.0	COG0542@1|root,COG0542@2|Bacteria,3J0B4@40117|Nitrospirae	40117|Nitrospirae	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
TH2_k127_1153275_8	289376.THEYE_A0252	2.698e-42	162.0	COG0526@1|root,COG0526@2|Bacteria,3J0SG@40117|Nitrospirae	40117|Nitrospirae	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TH2_k127_1153275_7	289376.THEYE_A0253	5.152e-53	193.0	2CA4A@1|root,32RQK@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4416)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4416
TH2_k127_1153275_12	316067.Geob_2596	1.923e-16	89.0	COG2133@1|root,COG3292@1|root,COG4733@1|root,COG2133@2|Bacteria,COG3292@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	ko:K12287	-	-	-	-	ko00000,ko02044	-	-	-	CHB_HEX_C_1,DUF1906,Malectin,fn3
TH2_k127_1153275_9	177437.HRM2_06090	3.437e-42	162.0	COG4195@1|root,COG4195@2|Bacteria,1MZZB@1224|Proteobacteria,42U90@68525|delta/epsilon subdivisions,2WQGX@28221|Deltaproteobacteria,2MKFP@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Poly-gamma-glutamate hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Gamma_PGA_hydro
TH2_k127_1159870_1	289376.THEYE_A0567	9.629e-201	630.0	COG1960@1|root,COG1960@2|Bacteria,3J13U@40117|Nitrospirae	40117|Nitrospirae	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TH2_k127_1159870_3	349161.Dred_1049	1.352e-100	344.0	COG0312@1|root,COG0312@2|Bacteria,1TQJ5@1239|Firmicutes,24AGW@186801|Clostridia,260PT@186807|Peptococcaceae	186801|Clostridia	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
TH2_k127_1159870_6	289376.THEYE_A0569	5.365e-46	168.0	COG0720@1|root,COG0720@2|Bacteria,3J0TW@40117|Nitrospirae	40117|Nitrospirae	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
TH2_k127_1159870_5	289376.THEYE_A0570	2.548e-62	218.0	COG0634@1|root,COG0634@2|Bacteria,3J0NZ@40117|Nitrospirae	40117|Nitrospirae	F	Phosphoribosyl transferase domain	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
TH2_k127_1159870_4	1121004.ATVC01000071_gene1166	3.334e-78	271.0	COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2VK14@28216|Betaproteobacteria,2KPU8@206351|Neisseriales	206351|Neisseriales	S	Phospholipase, patatin family	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
TH2_k127_1159870_0	289376.THEYE_A1137	1.298e-219	717.0	COG1074@1|root,COG1074@2|Bacteria,3J16M@40117|Nitrospirae	40117|Nitrospirae	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
TH2_k127_1159870_2	1123376.AUIU01000012_gene1395	1.163e-200	659.0	COG2887@1|root,COG2887@2|Bacteria	2|Bacteria	L	Belongs to the helicase family. UvrD subfamily	-	-	-	-	-	-	-	-	-	-	-	-	AAA_24,PDDEXK_1
TH2_k127_1163785_11	1304885.AUEY01000052_gene1548	2.958e-13	74.0	COG1538@1|root,COG1538@2|Bacteria,1PCPQ@1224|Proteobacteria,42PZ3@68525|delta/epsilon subdivisions,2WJU4@28221|Deltaproteobacteria,2MIHB@213118|Desulfobacterales	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TH2_k127_1163785_9	1304885.AUEY01000052_gene1549	4.316e-26	117.0	2CCD9@1|root,2ZWK6@2|Bacteria	2|Bacteria	S	YtkA-like	-	-	-	-	-	-	-	-	-	-	-	-	YtkA
TH2_k127_1163785_2	123214.PERMA_0513	2.108e-87	305.0	COG2204@1|root,COG2204@2|Bacteria,2G4HS@200783|Aquificae	200783|Aquificae	K	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
TH2_k127_1163785_5	338966.Ppro_3690	3.275e-64	238.0	COG0642@1|root,COG3850@1|root,COG2205@2|Bacteria,COG3850@2|Bacteria,1N17V@1224|Proteobacteria,43BZS@68525|delta/epsilon subdivisions,2WUKS@28221|Deltaproteobacteria,43TBT@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TH2_k127_1163785_4	1118054.CAGW01000012_gene4026	1.293e-67	237.0	COG0745@1|root,COG0745@2|Bacteria,1U3FH@1239|Firmicutes,4HF9S@91061|Bacilli,26U6I@186822|Paenibacillaceae	91061|Bacilli	T	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TH2_k127_1163785_10	1121440.AUMA01000016_gene133	2.927e-21	101.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,42MP1@68525|delta/epsilon subdivisions,2WJPD@28221|Deltaproteobacteria,2M7S0@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	phoB	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TH2_k127_1163785_3	234267.Acid_7838	1.232e-83	306.0	COG4252@1|root,COG5002@1|root,COG4252@2|Bacteria,COG5002@2|Bacteria,3Y7KI@57723|Acidobacteria	57723|Acidobacteria	T	CHASE2	-	-	-	-	-	-	-	-	-	-	-	-	CHASE2,HATPase_c,HisKA
TH2_k127_1163785_7	289376.THEYE_A0458	9.54e-54	205.0	COG0617@1|root,COG0617@2|Bacteria	2|Bacteria	J	CTP:tRNA cytidylyltransferase activity	cca	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974,ko:K07276,ko:K19545	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko01504,ko03016,ko03019	-	-	-	Aminoglyc_resit,HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
TH2_k127_1163785_8	760568.Desku_2056	4.353e-49	179.0	COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,24J90@186801|Clostridia,2626H@186807|Peptococcaceae	186801|Clostridia	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	-	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
TH2_k127_1163785_0	289376.THEYE_A0631	1.34e-221	693.0	COG1158@1|root,COG1158@2|Bacteria,3J0BK@40117|Nitrospirae	40117|Nitrospirae	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
TH2_k127_1163785_6	1191523.MROS_1493	3.4e-58	226.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,Response_reg
TH2_k127_1163785_1	880073.Calab_3404	2.318e-122	408.0	COG2204@1|root,COG2204@2|Bacteria,2NNWS@2323|unclassified Bacteria	2|Bacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02667,ko:K07714	ko02020,map02020	M00500,M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH2_k127_1163785_12	1123371.ATXH01000031_gene2157	2.365e-09	59.0	2AR6P@1|root,31GGB@2|Bacteria,2GIGX@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
TH2_k127_1245136_3	589865.DaAHT2_2475	8.819e-193	604.0	COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,42MZ4@68525|delta/epsilon subdivisions,2WJPB@28221|Deltaproteobacteria,2MJ8U@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
TH2_k127_1245136_9	1265505.ATUG01000001_gene4575	8.462e-74	274.0	2CD96@1|root,32XZD@2|Bacteria,1N5W5@1224|Proteobacteria,42UZ9@68525|delta/epsilon subdivisions,2WR27@28221|Deltaproteobacteria,2MKNA@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1245136_14	1265505.ATUG01000001_gene4576	4.769e-38	153.0	2CD95@1|root,32TF9@2|Bacteria,1N4QU@1224|Proteobacteria,42UX1@68525|delta/epsilon subdivisions,2WPZB@28221|Deltaproteobacteria,2MKR2@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1245136_13	269799.Gmet_3310	7.624e-51	188.0	COG3521@1|root,COG3521@2|Bacteria,1N5FF@1224|Proteobacteria,42UFY@68525|delta/epsilon subdivisions,2WQTG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Type VI secretion lipoprotein, VasD, EvfM, TssJ, VC_A0113	tssJ	-	-	-	-	-	-	-	-	-	-	-	T6SS-SciN
TH2_k127_1245136_4	243231.GSU0429	5.289e-192	609.0	COG3522@1|root,COG3522@2|Bacteria,1MXKE@1224|Proteobacteria,42PGN@68525|delta/epsilon subdivisions,2WKIA@28221|Deltaproteobacteria,43VK7@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Bacterial Type VI secretion, VC_A0110, EvfL, ImpJ, VasE	tssK	-	-	ko:K11893	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	T6SS_VasE
TH2_k127_1245136_6	269799.Gmet_0273	1.115e-85	289.0	COG3455@1|root,COG3455@2|Bacteria,1RGIR@1224|Proteobacteria,42S3K@68525|delta/epsilon subdivisions,2WNQ8@28221|Deltaproteobacteria,43VRK@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Type VI secretion system protein DotU	tssL	-	-	ko:K11892	ko03070,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	DotU
TH2_k127_1245136_0	269799.Gmet_0274	0.0	1297.0	COG3523@1|root,COG3523@2|Bacteria,1MV3D@1224|Proteobacteria,42PG2@68525|delta/epsilon subdivisions,2WM2G@28221|Deltaproteobacteria,43UWY@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	ImcF-related N-terminal domain	tssM	-	-	ko:K11891	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	IcmF-related,IcmF_C,ImcF-related_N
TH2_k127_1245136_11	243231.GSU3167	3.543e-56	209.0	COG3515@1|root,COG3913@1|root,COG3515@2|Bacteria,COG3913@2|Bacteria,1NKX3@1224|Proteobacteria,42VHK@68525|delta/epsilon subdivisions,2WRXN@28221|Deltaproteobacteria,43VHU@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	ImpA, N-terminal, type VI secretion system	-	-	-	ko:K11910	-	M00334	-	-	ko00000,ko00002,ko02044	3.A.23.1	-	-	DUF2094,ImpA_N,T6SS_VasJ
TH2_k127_1245136_12	330214.NIDE1975	4.58e-52	194.0	COG4455@1|root,COG4455@2|Bacteria	2|Bacteria	U	Protein of avirulence locus involved in temperature-dependent protein secretion	impE	-	-	ko:K03217,ko:K11898	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	ImpE,TPR_19
TH2_k127_1245136_5	1265505.ATUG01000001_gene4582	8.257e-126	418.0	COG3515@1|root,COG3515@2|Bacteria,1MY80@1224|Proteobacteria,42VE0@68525|delta/epsilon subdivisions,2WSAE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	ImpA, N-terminal, type VI secretion system	-	-	-	ko:K11902	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	ImpA_N,T6SS_VasJ
TH2_k127_1245136_8	1265505.ATUG01000001_gene4583	1.68e-78	265.0	COG3516@1|root,COG3516@2|Bacteria,1R9Y7@1224|Proteobacteria,42UQR@68525|delta/epsilon subdivisions,2WQYW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Type VI secretion system, VipA, VC_A0107 or Hcp2	-	-	-	ko:K11901	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	T6SS_VipA
TH2_k127_1245136_1	1265505.ATUG01000001_gene4584	3.386e-262	813.0	COG3517@1|root,COG3517@2|Bacteria,1MU5C@1224|Proteobacteria,42M4A@68525|delta/epsilon subdivisions,2WJKU@28221|Deltaproteobacteria,2MIKN@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Type VI secretion protein, EvpB/VC_A0108, tail sheath	-	-	-	ko:K11900	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	T6SS_VipA,VipB
TH2_k127_1245136_10	1120999.JONM01000005_gene3770	3.303e-69	238.0	COG3157@1|root,COG3157@2|Bacteria,1RBTU@1224|Proteobacteria,2WEFR@28216|Betaproteobacteria,2KPCB@206351|Neisseriales	206351|Neisseriales	S	Type VI secretion system effector, Hcp	-	-	-	ko:K11903	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	T6SS_HCP
TH2_k127_1245136_16	404380.Gbem_3041	1.172e-35	141.0	COG3157@1|root,COG3157@2|Bacteria,1RBTU@1224|Proteobacteria,42XEQ@68525|delta/epsilon subdivisions,2WTD9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Type VI secretion system effector, Hcp	-	-	-	ko:K11903	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	T6SS_HCP
TH2_k127_1245136_15	1265505.ATUG01000001_gene4585	1.71e-37	147.0	COG3518@1|root,COG3518@2|Bacteria,1PT65@1224|Proteobacteria,42XTG@68525|delta/epsilon subdivisions,2WSNC@28221|Deltaproteobacteria,2MP91@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Gene 25-like lysozyme	-	-	-	ko:K11897	-	M00334	-	-	ko00000,ko00002,ko02044	-	-	-	GPW_gp25
TH2_k127_1245136_2	1265505.ATUG01000001_gene4586	4.929e-243	764.0	COG3519@1|root,COG3519@2|Bacteria,1MUY4@1224|Proteobacteria,42PR4@68525|delta/epsilon subdivisions,2WJCN@28221|Deltaproteobacteria,2MJYU@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Type VI secretion system, TssF	-	-	-	ko:K11896	-	M00334	-	-	ko00000,ko00002,ko02044	3.A.23.1	-	-	T6SS_TssF
TH2_k127_1245136_7	443143.GM18_3026	8.014e-81	282.0	COG3520@1|root,COG3520@2|Bacteria,1MWVS@1224|Proteobacteria,42UKI@68525|delta/epsilon subdivisions,2WQ70@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	type VI secretion protein	-	-	-	ko:K11895	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	T6SS_TssG
TH2_k127_1245136_18	1265505.ATUG01000001_gene4588	4.107e-09	57.0	COG0542@1|root,COG0542@2|Bacteria,1MVBH@1224|Proteobacteria,42PEV@68525|delta/epsilon subdivisions,2WKW5@28221|Deltaproteobacteria,2MJ1U@213118|Desulfobacterales	28221|Deltaproteobacteria	O	C-terminal, D2-small domain, of ClpB protein	tssH	-	-	ko:K11907	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
TH2_k127_1281624_6	289376.THEYE_A0621	1.425e-17	86.0	COG3027@1|root,COG3027@2|Bacteria	2|Bacteria	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	zapA	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
TH2_k127_1281624_3	289376.THEYE_A0623	3.618e-118	404.0	COG0457@1|root,COG0741@1|root,COG1729@1|root,COG0457@2|Bacteria,COG0741@2|Bacteria,COG1729@2|Bacteria,3J0VD@40117|Nitrospirae	40117|Nitrospirae	M	Transglycosylase SLT domain	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,TPR_3,TPR_6
TH2_k127_1281624_1	289376.THEYE_A0624	1.033e-142	462.0	COG0082@1|root,COG0082@2|Bacteria,3J0KQ@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
TH2_k127_1281624_4	243231.GSU1492	5.229e-102	344.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WIMF@28221|Deltaproteobacteria,43TEX@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	Type II/IV secretion system protein	pilT-4	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
TH2_k127_1281624_2	1306174.JODP01000013_gene7524	1.12e-122	404.0	COG2805@1|root,COG2805@2|Bacteria,2I9GT@201174|Actinobacteria	201174|Actinobacteria	NU	twitching motility protein	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
TH2_k127_1281624_0	1123376.AUIU01000014_gene604	0.0	1242.0	COG0653@1|root,COG0653@2|Bacteria,3J0E5@40117|Nitrospirae	40117|Nitrospirae	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
TH2_k127_1281624_5	102125.Xen7305DRAFT_00001700	2.534e-52	198.0	COG1621@1|root,COG3291@1|root,COG1621@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBM_35,CBM_6,CHU_C,DUF608,Glyco_hydr_116N,He_PIG
TH2_k127_132276_3	760568.Desku_2103	3.734e-46	169.0	COG0175@1|root,COG0175@2|Bacteria,1U1VN@1239|Firmicutes,248Y9@186801|Clostridia,262VR@186807|Peptococcaceae	186801|Clostridia	EH	PFAM Phosphoadenosine phosphosulfate reductase	cysD	-	1.8.4.10,1.8.4.8,2.7.7.4	ko:K00390,ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R02021,R04929	RC00007,RC02809,RC02862,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
TH2_k127_132276_6	1463936.JOJI01000031_gene2169	2.794e-26	126.0	COG3119@1|root,COG3119@2|Bacteria,2H362@201174|Actinobacteria	201174|Actinobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TH2_k127_132276_2	610130.Closa_0541	3.344e-51	191.0	COG1682@1|root,COG1682@2|Bacteria,1V1J2@1239|Firmicutes,25B57@186801|Clostridia,2209P@1506553|Lachnoclostridium	186801|Clostridia	GM	Transport permease protein	pyrL	-	-	ko:K01992,ko:K09690	ko02010,map02010	M00250,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.103	-	-	ABC2_membrane
TH2_k127_132276_0	445972.ANACOL_02160	1.085e-68	250.0	COG1134@1|root,COG1134@2|Bacteria,1TQKK@1239|Firmicutes,24A5V@186801|Clostridia,3WHVP@541000|Ruminococcaceae	186801|Clostridia	GM	Psort location CytoplasmicMembrane, score	rfbB	-	-	ko:K01990,ko:K09691	ko02010,map02010	M00250,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.103	-	-	ABC_tran
TH2_k127_132276_5	926569.ANT_29290	2.727e-38	160.0	COG0438@1|root,COG2227@1|root,COG0438@2|Bacteria,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_transf_56,Glycos_transf_1,Glycos_transf_2,Methyltransf_11,Methyltransf_23,Methyltransf_31
TH2_k127_132276_4	649747.HMPREF0083_02294	8.398e-42	171.0	COG0438@1|root,COG0438@2|Bacteria,1V0G0@1239|Firmicutes,4HCG7@91061|Bacilli,26ZNF@186822|Paenibacillaceae	91061|Bacilli	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TH2_k127_132276_1	1125863.JAFN01000001_gene2355	5.107e-60	225.0	COG3210@1|root,COG5492@1|root,COG3210@2|Bacteria,COG5492@2|Bacteria,1PFJ7@1224|Proteobacteria,42WVE@68525|delta/epsilon subdivisions	1224|Proteobacteria	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1355647_14	765912.Thimo_2911	1.266e-52	187.0	COG1449@1|root,COG1449@2|Bacteria,1R3Z3@1224|Proteobacteria,1RNRC@1236|Gammaproteobacteria,1WVY7@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
TH2_k127_1355647_9	1116472.MGMO_66c00480	6.21e-105	353.0	COG0438@1|root,COG0438@2|Bacteria,1PIF6@1224|Proteobacteria,1S09H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Glycosyl transferases group 1	walM	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
TH2_k127_1355647_17	1033802.SSPSH_000620	2.741e-22	109.0	COG2067@1|root,COG2067@2|Bacteria,1RFDS@1224|Proteobacteria,1SBRG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Protein of unknown function (DUF3187)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3187
TH2_k127_1355647_15	289376.THEYE_A2064	1.104e-45	176.0	COG1639@1|root,COG1639@2|Bacteria,3J0NC@40117|Nitrospirae	40117|Nitrospirae	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
TH2_k127_1355647_10	880072.Desac_2725	9.91e-88	293.0	COG2406@1|root,COG2406@2|Bacteria,1RE25@1224|Proteobacteria,42PJ1@68525|delta/epsilon subdivisions,2WNTY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Ferritin Dps family protein	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
TH2_k127_1355647_4	251221.35211733	3.546e-119	391.0	COG0837@1|root,COG0837@2|Bacteria,1G1TJ@1117|Cyanobacteria	1117|Cyanobacteria	G	Belongs to the bacterial glucokinase family	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase
TH2_k127_1355647_12	1123371.ATXH01000008_gene269	2.06e-59	223.0	COG4885@1|root,COG4885@2|Bacteria	2|Bacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT,Cytochrome_C554
TH2_k127_1355647_16	1454004.AW11_03982	7.22e-23	106.0	2DZRB@1|root,32VGU@2|Bacteria,1NK4X@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1355647_2	289376.THEYE_A0984	3.555e-235	743.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria	2|Bacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	porA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1164	PFOR_II,POR,POR_N,Transketolase_C
TH2_k127_1355647_6	747365.Thena_0893	3.139e-107	354.0	COG1013@1|root,COG1013@2|Bacteria,1TQJ2@1239|Firmicutes,25CAJ@186801|Clostridia,42FZW@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM 2-oxoacid acceptor oxidoreductase, beta subunit, pyruvate 2-ketoisovalerate	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
TH2_k127_1355647_1	335543.Sfum_3591	2.029e-288	893.0	COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,42MNB@68525|delta/epsilon subdivisions,2WJ0I@28221|Deltaproteobacteria,2MRE4@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	hexose biosynthetic process	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
TH2_k127_1355647_8	56780.SYN_01262	5.359e-105	347.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,42MR1@68525|delta/epsilon subdivisions,2WKC9@28221|Deltaproteobacteria,2MQW9@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
TH2_k127_1355647_3	909663.KI867149_gene3359	2.13e-165	537.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42NI4@68525|delta/epsilon subdivisions,2WKRT@28221|Deltaproteobacteria,2MQX9@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran,GGDEF
TH2_k127_1355647_13	909663.KI867149_gene3360	1.035e-56	203.0	COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,42SCT@68525|delta/epsilon subdivisions,2WPA7@28221|Deltaproteobacteria,2MQJI@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
TH2_k127_1355647_11	338966.Ppro_0559	5.545e-71	250.0	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,42RII@68525|delta/epsilon subdivisions,2WNS9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM VacJ family lipoprotein	-	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
TH2_k127_1355647_5	56780.SYN_00283	3.992e-116	381.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42P6Q@68525|delta/epsilon subdivisions,2WKPS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	PFAM ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TH2_k127_1355647_0	56780.SYN_00284	1.596e-301	943.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,42PQC@68525|delta/epsilon subdivisions,2WJ8K@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TH2_k127_1355647_7	1123392.AQWL01000007_gene879	1.906e-106	358.0	COG0845@1|root,COG0845@2|Bacteria,1PJHF@1224|Proteobacteria,2VIRN@28216|Betaproteobacteria,1KSR8@119069|Hydrogenophilales	119069|Hydrogenophilales	M	HlyD family secretion protein	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_3
TH2_k127_1356538_2	404380.Gbem_1161	2.676e-137	440.0	COG0755@1|root,COG0755@2|Bacteria	2|Bacteria	O	cytochrome complex assembly	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
TH2_k127_1356538_0	404380.Gbem_1163	1.526e-240	748.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42MCH@68525|delta/epsilon subdivisions,2WJPZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
TH2_k127_1356538_16	323259.Mhun_0893	1.581e-18	93.0	COG2340@1|root,arCOG03962@2157|Archaea	2157|Archaea	S	protein with SCP PR1 domains	-	-	-	-	-	-	-	-	-	-	-	-	CAP
TH2_k127_1356538_1	1123376.AUIU01000019_gene1253	4.192e-152	499.0	COG1232@1|root,COG1232@2|Bacteria,3J0PQ@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	-	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
TH2_k127_1356538_5	243231.GSU3312	3.251e-92	314.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,42M0C@68525|delta/epsilon subdivisions,2WMJ2@28221|Deltaproteobacteria,43TS8@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
TH2_k127_1356538_9	289376.THEYE_A0981	6.287e-64	225.0	COG0163@1|root,COG0163@2|Bacteria	2|Bacteria	H	prenyltransferase activity	ubiX	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008694,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.5.1.129	ko:K03186,ko:K16875	ko00130,ko00365,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00365,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R10213,R11225	RC00391,RC00814,RC03086,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2311,iAF987.Gmet_3392,iAPECO1_1312.APECO1_4253,iB21_1397.B21_02196,iBWG_1329.BWG_2085,iE2348C_1286.E2348C_2451,iEC55989_1330.EC55989_2555,iECBD_1354.ECBD_1348,iECB_1328.ECB_02236,iECDH10B_1368.ECDH10B_2473,iECDH1ME8569_1439.ECDH1ME8569_2249,iECD_1391.ECD_02236,iECED1_1282.ECED1_2775,iECH74115_1262.ECH74115_3451,iECIAI39_1322.ECIAI39_2460,iECNA114_1301.ECNA114_2401,iECO103_1326.ECO103_2775,iECOK1_1307.ECOK1_2544,iECP_1309.ECP_2350,iECS88_1305.ECS88_2458,iECSE_1348.ECSE_2620,iECSF_1327.ECSF_2187,iECSP_1301.ECSP_3186,iECs_1301.ECs3195,iETEC_1333.ETEC_2447,iEcDH1_1363.EcDH1_1345,iEcE24377_1341.EcE24377A_2605,iEcHS_1320.EcHS_A2462,iEcSMS35_1347.EcSMS35_2467,iG2583_1286.G2583_2848,iJO1366.b2311,iJR904.b2311,iLF82_1304.LF82_2354,iNRG857_1313.NRG857_11705,iSDY_1059.SDY_2510,iUMN146_1321.UM146_05255,iUMNK88_1353.UMNK88_2862,iUTI89_1310.UTI89_C2595,iY75_1357.Y75_RS12120,iZ_1308.Z3573	Flavoprotein
TH2_k127_1356538_4	1123376.AUIU01000019_gene1280	8.14e-109	362.0	COG2870@1|root,COG2870@2|Bacteria,3J0GT@40117|Nitrospirae	40117|Nitrospirae	M	Phosphomethylpyrimidine kinase	-	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	PfkB
TH2_k127_1356538_8	338966.Ppro_1071	1.251e-79	277.0	COG0301@1|root,COG0301@2|Bacteria,1N1R1@1224|Proteobacteria,42MQ9@68525|delta/epsilon subdivisions,2WJPN@28221|Deltaproteobacteria,43T42@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Thiamine biosynthesis protein (ThiI)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,ThiI
TH2_k127_1356538_7	1131269.AQVV01000015_gene2041	6.529e-84	291.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	rfaG	-	-	ko:K02844	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
TH2_k127_1356538_17	28176.CF66_4017	3.043e-05	56.0	COG3307@1|root,COG3307@2|Bacteria,1R8PC@1224|Proteobacteria,1RYYV@1236|Gammaproteobacteria,1XWTS@135623|Vibrionales	135623|Vibrionales	M	COG3307 Lipid A core - O-antigen ligase and related enzymes	waaL	-	-	ko:K02847	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	9.B.67.4,9.B.67.5	-	-	Wzy_C
TH2_k127_1356538_10	760568.Desku_1557	5.518e-59	222.0	COG0438@1|root,COG0438@2|Bacteria,1TPY6@1239|Firmicutes,24834@186801|Clostridia,261PX@186807|Peptococcaceae	186801|Clostridia	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TH2_k127_1356538_13	32024.JMTI01000003_gene1609	2.835e-51	195.0	COG0438@1|root,COG0438@2|Bacteria,1R8BR@1224|Proteobacteria	1224|Proteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
TH2_k127_1356538_14	941449.dsx2_0241	9.412e-40	160.0	COG4641@1|root,COG4641@2|Bacteria,1R64N@1224|Proteobacteria,42N73@68525|delta/epsilon subdivisions,2WM84@28221|Deltaproteobacteria,2M7XA@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	DUF based on E. rectale Gene description (DUF3880)	-	-	-	ko:K06320	-	-	-	-	ko00000	-	-	-	DUF3880,Glyco_trans_1_2
TH2_k127_1356538_6	880072.Desac_1891	2.158e-84	292.0	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,42MJR@68525|delta/epsilon subdivisions,2WPGB@28221|Deltaproteobacteria,2MRND@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	PFAM glycosyl transferase, family 9	-	-	-	ko:K02849	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
TH2_k127_1356538_3	177437.HRM2_09530	2.524e-113	388.0	COG3083@1|root,COG3083@2|Bacteria,1MX6X@1224|Proteobacteria,42R7V@68525|delta/epsilon subdivisions,2WN3A@28221|Deltaproteobacteria,2MMB0@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF3413)	-	-	-	ko:K07014	-	-	-	-	ko00000	-	-	-	DUF3413,Sulfatase
TH2_k127_1356538_11	485916.Dtox_1638	5.56e-59	218.0	COG0438@1|root,COG0438@2|Bacteria,1TPS8@1239|Firmicutes,25ESM@186801|Clostridia	186801|Clostridia	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TH2_k127_1356538_12	289376.THEYE_A2095	8.397e-58	205.0	COG0463@1|root,COG0463@2|Bacteria,3J0M5@40117|Nitrospirae	40117|Nitrospirae	M	biosynthesis glycosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TH2_k127_1417433_10	313606.M23134_06723	4.598e-34	151.0	COG3391@1|root,COG3405@1|root,COG3391@2|Bacteria,COG3405@2|Bacteria,4NNI8@976|Bacteroidetes	976|Bacteroidetes	E	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
TH2_k127_1417433_15	1177154.Y5S_02338	1.571e-22	113.0	COG1879@1|root,COG1879@2|Bacteria,1MYP5@1224|Proteobacteria,1S84T@1236|Gammaproteobacteria,1XQEW@135619|Oceanospirillales	1236|Gammaproteobacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	Flg_new
TH2_k127_1417433_12	1385517.N800_00445	3.971e-29	135.0	COG1404@1|root,COG4935@1|root,COG1404@2|Bacteria,COG4935@2|Bacteria,1PH1W@1224|Proteobacteria,1RRYP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Metallo-peptidase family M12	-	-	-	-	-	-	-	-	-	-	-	-	CBM_4_9,P_proprotein,Reprolysin_3,Reprolysin_4
TH2_k127_1417433_11	398767.Glov_2914	3.054e-32	147.0	COG0028@1|root,COG1361@1|root,COG3386@1|root,COG3468@1|root,COG0028@2|Bacteria,COG1361@2|Bacteria,COG3386@2|Bacteria,COG3468@2|Bacteria,1QVSF@1224|Proteobacteria	1224|Proteobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,DUF11,DUF1566,Laminin_G_3,OmpA,OmpA_membrane,TIG
TH2_k127_1417433_14	680646.RMDY18_18820	1.185e-22	115.0	COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria,1W8TR@1268|Micrococcaceae	201174|Actinobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,PA,Peptidase_S8,SLH,fn3_5
TH2_k127_1417433_18	491915.Aflv_2604	2.116e-09	69.0	COG4632@1|root,COG4632@2|Bacteria,1VK1E@1239|Firmicutes,4HV96@91061|Bacilli,21WWG@150247|Anoxybacillus	91061|Bacilli	G	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
TH2_k127_1417433_17	316067.Geob_2596	5.554e-16	90.0	COG2133@1|root,COG3292@1|root,COG4733@1|root,COG2133@2|Bacteria,COG3292@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	ko:K12287	-	-	-	-	ko00000,ko02044	-	-	-	CHB_HEX_C_1,DUF1906,Malectin,fn3
TH2_k127_1417433_2	667014.Thein_0887	7.057e-178	571.0	COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,2GHF8@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	Mannose-6-phosphate isomerase, type	-	-	2.7.7.13,5.3.1.8	ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
TH2_k127_1417433_9	479434.Sthe_0904	2.862e-46	181.0	COG0438@1|root,COG0438@2|Bacteria,2G5PS@200795|Chloroflexi,27XVU@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TH2_k127_1417433_6	909663.KI867149_gene3426	1.587e-91	311.0	COG1216@1|root,COG1216@2|Bacteria,1N1TF@1224|Proteobacteria,42VI6@68525|delta/epsilon subdivisions,2WRG7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Glycosyl transferase family 2	-	-	-	ko:K12992	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01005	-	GT2	-	Glycos_transf_2
TH2_k127_1417433_8	1123372.AUIT01000030_gene256	9.809e-78	264.0	COG1898@1|root,COG1898@2|Bacteria,2GHU3@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
TH2_k127_1417433_7	1183377.Py04_0482	2.847e-80	278.0	COG1091@1|root,arCOG01367@2157|Archaea,2XVV7@28890|Euryarchaeota,243PG@183968|Thermococci	183968|Thermococci	M	RmlD substrate binding domain	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
TH2_k127_1417433_5	436114.SYO3AOP1_1395	7.059e-105	366.0	COG2148@1|root,COG2148@2|Bacteria,2G3XH@200783|Aquificae	200783|Aquificae	M	sugar transferase	-	-	2.7.8.6	ko:K00996	-	-	-	-	ko00000,ko01000,ko01005	-	-	-	Bac_transf,CoA_binding_3
TH2_k127_1417433_19	1300143.CCAV010000001_gene955	5.466e-06	49.0	29EH7@1|root,301F5@2|Bacteria,4PGMM@976|Bacteroidetes,1IHES@117743|Flavobacteriia,3ZU3J@59732|Chryseobacterium	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1417433_16	1242864.D187_008392	2.718e-19	98.0	COG3063@1|root,COG3063@2|Bacteria,1RK88@1224|Proteobacteria,42SIP@68525|delta/epsilon subdivisions,2WPT7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	TPR repeat	tgl	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_6,TPR_8
TH2_k127_1417433_0	1123376.AUIU01000014_gene524	2.222e-264	850.0	COG1197@1|root,COG1197@2|Bacteria,3J0BA@40117|Nitrospirae	40117|Nitrospirae	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
TH2_k127_1417433_13	1121406.JAEX01000015_gene578	5.133e-27	116.0	COG0492@1|root,COG0526@1|root,COG0492@2|Bacteria,COG0526@2|Bacteria,1R05R@1224|Proteobacteria,42QEV@68525|delta/epsilon subdivisions,2WMBG@28221|Deltaproteobacteria,2M9F6@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Thioredoxin_3
TH2_k127_1417433_4	1121456.ATVA01000012_gene2845	7.213e-124	408.0	COG0492@1|root,COG0526@1|root,COG0492@2|Bacteria,COG0526@2|Bacteria,1R05R@1224|Proteobacteria,42QEV@68525|delta/epsilon subdivisions,2WMBG@28221|Deltaproteobacteria,2M9F6@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Thioredoxin_3
TH2_k127_1417433_1	932678.THERU_05370	1.176e-237	751.0	COG1331@1|root,COG1331@2|Bacteria	2|Bacteria	O	Highly conserved protein containing a thioredoxin domain	yyaL	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
TH2_k127_1417433_3	338966.Ppro_0511	2.492e-141	482.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,42MCT@68525|delta/epsilon subdivisions,2WINW@28221|Deltaproteobacteria,43T20@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
TH2_k127_1427166_12	1123376.AUIU01000011_gene1017	1.799e-26	112.0	2C5I4@1|root,33FNH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1427166_2	243231.GSU2937	9.513e-121	396.0	293RH@1|root,2ZR74@2|Bacteria,1RGTJ@1224|Proteobacteria,42RWW@68525|delta/epsilon subdivisions,2WNTI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
TH2_k127_1427166_11	667014.Thein_0238	1.565e-29	121.0	2C5I4@1|root,33FNH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1427166_6	289376.THEYE_A1559	1.315e-65	233.0	COG0030@1|root,COG0030@2|Bacteria,3J0R6@40117|Nitrospirae	40117|Nitrospirae	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
TH2_k127_1427166_5	472759.Nhal_2557	3.806e-88	300.0	COG1295@1|root,COG1295@2|Bacteria,1NH82@1224|Proteobacteria,1S3T8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ribonuclease BN	-	-	-	-	-	-	-	-	-	-	-	-	Virul_fac_BrkB
TH2_k127_1427166_0	243231.GSU0285	7.97e-168	538.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,42MG8@68525|delta/epsilon subdivisions,2WJWP@28221|Deltaproteobacteria,43S0X@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
TH2_k127_1427166_7	525904.Tter_0647	3.369e-61	219.0	COG0351@1|root,COG0351@2|Bacteria,2NP3M@2323|unclassified Bacteria	2|Bacteria	H	Phosphomethylpyrimidine kinase	thiD	GO:0008150,GO:0040007	2.5.1.3,2.7.1.35,2.7.1.49,2.7.4.7,4.1.99.17	ko:K00868,ko:K00941,ko:K03147,ko:K21219	ko00730,ko00750,ko01100,map00730,map00750,map01100	M00127	R00174,R01909,R02493,R03223,R03471,R03472,R04509,R10712	RC00002,RC00017,RC00224,RC03251,RC03252,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS03115	Phos_pyr_kin
TH2_k127_1427166_8	1123376.AUIU01000016_gene289	1.659e-56	201.0	COG0102@1|root,COG0102@2|Bacteria,3J0NE@40117|Nitrospirae	40117|Nitrospirae	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
TH2_k127_1427166_10	289376.THEYE_A1581	1.293e-50	183.0	COG0103@1|root,COG0103@2|Bacteria,3J0N4@40117|Nitrospirae	40117|Nitrospirae	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
TH2_k127_1427166_1	289376.THEYE_A1580	4.177e-128	421.0	COG0002@1|root,COG0002@2|Bacteria,3J0H9@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
TH2_k127_1427166_4	1121937.AUHJ01000004_gene1117	2.636e-91	319.0	COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,1RMKI@1236|Gammaproteobacteria,4669T@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	membrane	rbn	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TH2_k127_1427166_9	1121035.AUCH01000005_gene125	7.25e-56	205.0	COG2199@1|root,COG3706@2|Bacteria,1MYK0@1224|Proteobacteria	1224|Proteobacteria	T	COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
TH2_k127_1462329_0	335543.Sfum_0739	1.283e-221	697.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,42KZI@68525|delta/epsilon subdivisions,2WJ2C@28221|Deltaproteobacteria,2MQX8@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Domain of unknown function (DUF3458_C) ARM repeats	pepN	-	3.4.11.2	ko:K01256,ko:K08776	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,ERAP1_C,HEAT_2,Peptidase_M1
TH2_k127_1462329_15	269799.Gmet_1882	5.477e-45	168.0	COG3448@1|root,COG3448@2|Bacteria,1QXNX@1224|Proteobacteria,43C4S@68525|delta/epsilon subdivisions,2X7F6@28221|Deltaproteobacteria,43UX4@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TH2_k127_1462329_19	394503.Ccel_0799	1.419e-23	108.0	COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,24MSS@186801|Clostridia,36IUF@31979|Clostridiaceae	186801|Clostridia	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	ydiB	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
TH2_k127_1462329_5	671143.DAMO_0325	1.042e-97	335.0	COG0061@1|root,COG0061@2|Bacteria,2NP7T@2323|unclassified Bacteria	2|Bacteria	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iEcSMS35_1347.EcSMS35_2767,iHN637.CLJU_RS05480,iLJ478.TM1733,iSB619.SA_RS04895	NAD_kinase
TH2_k127_1462329_10	289376.THEYE_A0658	5.269e-72	252.0	COG1573@1|root,COG1573@2|Bacteria,3J0MR@40117|Nitrospirae	40117|Nitrospirae	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TH2_k127_1462329_8	289376.THEYE_A0660	5.876e-83	279.0	COG0279@1|root,COG0279@2|Bacteria,3J0HG@40117|Nitrospirae	40117|Nitrospirae	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
TH2_k127_1462329_17	1121878.AUGL01000021_gene2773	1.208e-33	139.0	COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,1RQPJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
TH2_k127_1462329_14	1131269.AQVV01000002_gene1184	7.938e-46	175.0	COG0632@1|root,COG0632@2|Bacteria	2|Bacteria	L	four-way junction helicase activity	ruvA	GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
TH2_k127_1462329_2	289376.THEYE_A0876	1.019e-151	486.0	COG2255@1|root,COG2255@2|Bacteria,3J0AU@40117|Nitrospirae	40117|Nitrospirae	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
TH2_k127_1462329_11	515635.Dtur_1611	9.046e-61	215.0	COG1636@1|root,COG1636@2|Bacteria	2|Bacteria	C	queuosine biosynthetic process	queH	-	1.17.99.6,3.1.26.4	ko:K03470,ko:K09765	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03032	-	-	-	DUF208
TH2_k127_1462329_22	289376.THEYE_A0874	2.817e-19	92.0	2DNS1@1|root,32YVX@2|Bacteria,3J1CZ@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF2905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2905
TH2_k127_1462329_9	289376.THEYE_A0873	3.549e-80	280.0	COG2385@1|root,COG2385@2|Bacteria,3J15K@40117|Nitrospirae	40117|Nitrospirae	D	Stage II sporulation protein	-	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	SpoIID
TH2_k127_1462329_4	289376.THEYE_A0872	1.801e-98	334.0	COG0809@1|root,COG0809@2|Bacteria,3J0HB@40117|Nitrospirae	40117|Nitrospirae	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
TH2_k127_1462329_27	1122137.AQXF01000002_gene241	1.575e-05	55.0	COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,2TUER@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
TH2_k127_1462329_3	1499967.BAYZ01000057_gene4687	4.032e-108	359.0	COG1702@1|root,COG1702@2|Bacteria,2NNZF@2323|unclassified Bacteria	2|Bacteria	T	PhoH-like protein	phoH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
TH2_k127_1462329_1	289376.THEYE_A0869	3.453e-152	499.0	COG1480@1|root,COG1480@2|Bacteria,3J11A@40117|Nitrospirae	40117|Nitrospirae	S	7TM receptor with intracellular HD hydrolase	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,HD
TH2_k127_1462329_20	1341151.ASZU01000004_gene366	5.928e-23	105.0	COG0319@1|root,COG0319@2|Bacteria,1V6BU@1239|Firmicutes,4HIIE@91061|Bacilli,27BV8@186824|Thermoactinomycetaceae	91061|Bacilli	S	Uncharacterized protein family UPF0054	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
TH2_k127_1462329_13	404380.Gbem_0999	4.081e-51	194.0	COG0671@1|root,COG0818@1|root,COG0671@2|Bacteria,COG0818@2|Bacteria,1Q5TS@1224|Proteobacteria,42SZA@68525|delta/epsilon subdivisions,2WPDT@28221|Deltaproteobacteria,43T24@69541|Desulfuromonadales	28221|Deltaproteobacteria	IM	Prokaryotic diacylglycerol kinase	-	-	2.7.1.107	ko:K00901	ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231	-	R02240	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_2369	DAGK_prokar,PAP2
TH2_k127_1462329_23	1336235.JAEG01000006_gene953	1.043e-18	94.0	COG0457@1|root,COG0457@2|Bacteria,1NG0U@1224|Proteobacteria,2U0YA@28211|Alphaproteobacteria,4B8S4@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	GlcNAc transferase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
TH2_k127_1462329_25	266834.SMc01933	2.488e-11	66.0	COG3905@1|root,COG3905@2|Bacteria,1NJ8V@1224|Proteobacteria,2UN8Y@28211|Alphaproteobacteria,4BHS5@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Ribbon-helix-helix protein, copG family	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
TH2_k127_1462329_12	522306.CAP2UW1_4419	6.764e-60	208.0	COG2329@1|root,COG2329@2|Bacteria,1RE6Q@1224|Proteobacteria,2VTH5@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
TH2_k127_1462329_24	1255043.TVNIR_2269	5.269e-17	81.0	2DPTZ@1|root,333CW@2|Bacteria,1NE58@1224|Proteobacteria,1SG82@1236|Gammaproteobacteria,1X20I@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1462329_18	880073.Calab_2166	8.172e-28	113.0	COG3668@1|root,COG3668@2|Bacteria,2NRK1@2323|unclassified Bacteria	2|Bacteria	S	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
TH2_k127_1462329_16	1123288.SOV_1c05010	1.441e-38	154.0	COG2885@1|root,COG2885@2|Bacteria,1V5EU@1239|Firmicutes	1239|Firmicutes	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
TH2_k127_1462329_21	903818.KI912268_gene2788	1.393e-19	89.0	COG2885@1|root,COG2885@2|Bacteria,3Y5IQ@57723|Acidobacteria	57723|Acidobacteria	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	DUF937,OmpA
TH2_k127_1462329_26	891968.Anamo_1242	1.56e-06	56.0	COG1943@1|root,COG1943@2|Bacteria,3TC5I@508458|Synergistetes	508458|Synergistetes	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
TH2_k127_1462329_6	909663.KI867150_gene2187	1.926e-93	314.0	COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,42MBJ@68525|delta/epsilon subdivisions,2WNWX@28221|Deltaproteobacteria,2MQKM@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
TH2_k127_1462329_7	289376.THEYE_A0860	2.389e-85	288.0	COG1210@1|root,COG1210@2|Bacteria,3J0B2@40117|Nitrospirae	40117|Nitrospirae	M	Nucleotidyl transferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TH2_k127_1525786_1	671143.DAMO_2945	7.57e-321	1000.0	COG0188@1|root,COG0188@2|Bacteria,2NNNR@2323|unclassified Bacteria	2|Bacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
TH2_k127_1525786_8	1379698.RBG1_1C00001G0480	1.241e-59	214.0	COG0639@1|root,COG0639@2|Bacteria,2NPHT@2323|unclassified Bacteria	2|Bacteria	T	Calcineurin-like phosphoesterase superfamily domain	apaH	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
TH2_k127_1525786_10	1123376.AUIU01000013_gene1880	4.296e-38	147.0	COG0781@1|root,COG0781@2|Bacteria,3J0RV@40117|Nitrospirae	40117|Nitrospirae	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
TH2_k127_1525786_7	1123376.AUIU01000013_gene1881	1.218e-69	239.0	COG0054@1|root,COG0054@2|Bacteria,3J0QT@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
TH2_k127_1525786_4	1123376.AUIU01000013_gene1882	1.003e-141	459.0	COG0772@1|root,COG0772@2|Bacteria,3J0IA@40117|Nitrospirae	40117|Nitrospirae	D	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
TH2_k127_1525786_3	330214.NIDE1016	4.789e-155	508.0	COG0768@1|root,COG0768@2|Bacteria,3J0FY@40117|Nitrospirae	40117|Nitrospirae	M	Penicillin-binding Protein dimerisation domain	-	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
TH2_k127_1525786_9	289376.THEYE_A1843	6.156e-50	189.0	COG1792@1|root,COG1792@2|Bacteria,3J0S3@40117|Nitrospirae	40117|Nitrospirae	M	shape-determining protein MreC	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
TH2_k127_1525786_2	289376.THEYE_A1842	8.46e-188	590.0	COG1077@1|root,COG1077@2|Bacteria,3J0BS@40117|Nitrospirae	40117|Nitrospirae	D	Actin	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
TH2_k127_1525786_11	1123376.AUIU01000013_gene1887	3.083e-28	118.0	COG1714@1|root,COG1714@2|Bacteria,3J0U3@40117|Nitrospirae	40117|Nitrospirae	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
TH2_k127_1525786_6	289376.THEYE_A1839	4.305e-114	376.0	COG0552@1|root,COG0552@2|Bacteria,3J0GY@40117|Nitrospirae	40117|Nitrospirae	D	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
TH2_k127_1525786_5	289376.THEYE_A0319	7.979e-137	443.0	COG0825@1|root,COG0825@2|Bacteria,3J0CN@40117|Nitrospirae	40117|Nitrospirae	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
TH2_k127_1525786_0	246194.CHY_1137	0.0	1039.0	COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,42EPB@68295|Thermoanaerobacterales	186801|Clostridia	L	TIGRFAM DNA polymerase III, alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
TH2_k127_154294_17	515635.Dtur_1767	9.27e-15	76.0	COG0310@1|root,COG0310@2|Bacteria	2|Bacteria	P	cobalt ion transport	cbiM	GO:0000041,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015675,GO:0016020,GO:0016021,GO:0030001,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM,PDGLE
TH2_k127_154294_9	608538.HTH_1378	1.037e-79	276.0	COG0709@1|root,COG0709@2|Bacteria,2G3ZH@200783|Aquificae	200783|Aquificae	F	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
TH2_k127_154294_4	1123376.AUIU01000011_gene1122	7.241e-126	413.0	COG0583@1|root,COG1910@1|root,COG0583@2|Bacteria,COG1910@2|Bacteria,3J16P@40117|Nitrospirae	40117|Nitrospirae	K	Transcriptional regulator	-	-	-	ko:K11921,ko:K19338	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
TH2_k127_154294_11	289376.THEYE_A1031	1.36e-45	176.0	COG1579@1|root,COG1579@2|Bacteria,3J0UV@40117|Nitrospirae	40117|Nitrospirae	S	C4-type zinc ribbon domain	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
TH2_k127_154294_6	204669.Acid345_4296	5.066e-104	356.0	COG0568@1|root,COG0568@2|Bacteria,3Y2XG@57723|Acidobacteria,2JHX1@204432|Acidobacteriia	204432|Acidobacteriia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TH2_k127_154294_5	289376.THEYE_A1028	3.104e-120	409.0	COG0358@1|root,COG0358@2|Bacteria,3J0IN@40117|Nitrospirae	40117|Nitrospirae	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4,Toprim_N,zf-CHC2
TH2_k127_154294_12	648996.Theam_0524	2.806e-40	153.0	COG1610@1|root,COG1610@2|Bacteria,2G4V2@200783|Aquificae	200783|Aquificae	S	Yqey-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
TH2_k127_154294_16	243231.GSU3093	3.526e-16	80.0	COG0828@1|root,COG0828@2|Bacteria,1MZCC@1224|Proteobacteria,42V6T@68525|delta/epsilon subdivisions,2WRAX@28221|Deltaproteobacteria,43VKN@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	structural constituent of ribosome	rpsU	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
TH2_k127_154294_15	880072.Desac_2668	6.683e-21	96.0	293FK@1|root,2ZQY0@2|Bacteria,1P4ZN@1224|Proteobacteria,432NW@68525|delta/epsilon subdivisions,2WXQQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_154294_10	289376.THEYE_A1034	2.647e-60	212.0	COG0778@1|root,COG0778@2|Bacteria,3J0UX@40117|Nitrospirae	40117|Nitrospirae	C	Nitroreductase family	-	-	1.13.11.79	ko:K04719	ko00740,ko01100,map00740,map01100	-	R09083	RC00435,RC02413	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
TH2_k127_154294_8	404380.Gbem_3396	5.715e-81	280.0	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,42MBA@68525|delta/epsilon subdivisions,2WKX9@28221|Deltaproteobacteria,43T73@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TH2_k127_154294_0	289376.THEYE_A1150	2.537e-214	678.0	COG0154@1|root,COG0154@2|Bacteria,3J0AA@40117|Nitrospirae	40117|Nitrospirae	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TH2_k127_154294_1	56780.SYN_00309	5.489e-199	631.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,42M31@68525|delta/epsilon subdivisions,2WJK4@28221|Deltaproteobacteria,2MQ8D@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
TH2_k127_154294_13	443143.GM18_3636	1.584e-25	109.0	2DRRJ@1|root,33CRQ@2|Bacteria	2|Bacteria	S	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
TH2_k127_154294_18	289376.THEYE_A1152	1.698e-07	57.0	28QXI@1|root,2ZDCM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_154294_2	289376.THEYE_A1153	4.813e-153	487.0	COG0115@1|root,COG0115@2|Bacteria,3J0BM@40117|Nitrospirae	40117|Nitrospirae	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
TH2_k127_154294_3	1121430.JMLG01000026_gene25	9.609e-153	496.0	COG1206@1|root,COG1206@2|Bacteria,1TP67@1239|Firmicutes,24971@186801|Clostridia,260G4@186807|Peptococcaceae	186801|Clostridia	J	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs	trmFO	-	2.1.1.74	ko:K04094	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	GIDA
TH2_k127_154294_7	289376.THEYE_A1395	2.723e-102	341.0	COG4974@1|root,COG4974@2|Bacteria,3J0PS@40117|Nitrospirae	40117|Nitrospirae	L	Phage integrase, N-terminal SAM-like domain	xerC	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TH2_k127_154294_14	1232410.KI421428_gene1166	1.725e-22	102.0	COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,42MEH@68525|delta/epsilon subdivisions,2WMSC@28221|Deltaproteobacteria,43SFW@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Proteasome subunit	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
TH2_k127_1643968_1	1123376.AUIU01000002_gene1667	3.73e-101	346.0	28KQH@1|root,2ZA8A@2|Bacteria	2|Bacteria	S	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
TH2_k127_1643968_4	391009.Tmel_1414	3.096e-30	122.0	COG3450@1|root,COG3450@2|Bacteria,2GDFM@200918|Thermotogae	200918|Thermotogae	S	Enzyme of the cupin superfamily	-	-	-	ko:K06995	-	-	-	-	ko00000	-	-	-	Cupin_3
TH2_k127_1643968_3	706587.Desti_1672	7.882e-51	183.0	COG0432@1|root,COG0432@2|Bacteria,1N5SN@1224|Proteobacteria,42SJC@68525|delta/epsilon subdivisions,2WP9F@28221|Deltaproteobacteria,2MRXI@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
TH2_k127_1643968_0	1123376.AUIU01000014_gene636	6.318e-226	723.0	COG1449@1|root,COG1449@2|Bacteria,3J0AQ@40117|Nitrospirae	40117|Nitrospirae	G	Glycosyl hydrolase family 57	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
TH2_k127_1643968_6	1499967.BAYZ01000170_gene5484	1.293e-07	58.0	COG2919@1|root,COG2919@2|Bacteria	2|Bacteria	D	cell cycle	divIC	-	-	ko:K05589,ko:K12065,ko:K13052	-	-	-	-	ko00000,ko02044,ko03036	3.A.7.11.1	-	-	DivIC
TH2_k127_1643968_2	269799.Gmet_1508	2.176e-99	330.0	COG0426@1|root,COG2768@1|root,COG0426@2|Bacteria,COG2768@2|Bacteria,1R85P@1224|Proteobacteria,42Q5N@68525|delta/epsilon subdivisions,2WJ3P@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	binding domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_9
TH2_k127_1643968_5	761193.Runsl_2214	5.49e-10	60.0	COG0642@1|root,COG2205@2|Bacteria,4NEFW@976|Bacteroidetes,47Y16@768503|Cytophagia	976|Bacteroidetes	T	His Kinase A (phosphoacceptor) domain	rprX	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
TH2_k127_1759753_0	118163.Ple7327_4539	8.53e-99	345.0	COG0823@1|root,COG1404@1|root,COG2931@1|root,COG0823@2|Bacteria,COG1404@2|Bacteria,COG2931@2|Bacteria,1GJ0J@1117|Cyanobacteria,3VIZ2@52604|Pleurocapsales	1117|Cyanobacteria	QU	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,SdrD_B
TH2_k127_1759753_4	690850.Desaf_0463	2.831e-30	126.0	COG0457@1|root,COG0457@2|Bacteria	690850.Desaf_0463|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1759753_2	1123376.AUIU01000014_gene616	5.666e-32	125.0	2EK9R@1|root,33E01@2|Bacteria,3J1B5@40117|Nitrospirae	40117|Nitrospirae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1759753_1	289376.THEYE_A1607	1.863e-49	187.0	COG0810@1|root,COG0810@2|Bacteria,3J0U0@40117|Nitrospirae	40117|Nitrospirae	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
TH2_k127_1759753_3	221288.JH992901_gene848	8.022e-31	136.0	COG0642@1|root,COG0745@1|root,COG0784@1|root,COG2203@1|root,COG5002@1|root,COG5278@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,COG5278@2|Bacteria,1G09B@1117|Cyanobacteria,1JH73@1189|Stigonemataceae	1117|Cyanobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF,GAF_2,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg
TH2_k127_193290_2	394221.Mmar10_0766	1.425e-12	70.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TSQF@28211|Alphaproteobacteria,43XBR@69657|Hyphomonadaceae	28211|Alphaproteobacteria	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	petR	-	-	ko:K07659	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TH2_k127_193290_0	1191523.MROS_2027	1.99e-63	235.0	COG0436@1|root,COG0436@2|Bacteria	2|Bacteria	E	Aminotransferase	alaA	GO:0003674,GO:0003824,GO:0004021,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0019842,GO:0030170,GO:0030632,GO:0032787,GO:0033554,GO:0036094,GO:0040007,GO:0042221,GO:0042851,GO:0042852,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0046677,GO:0047635,GO:0048037,GO:0050662,GO:0050896,GO:0051716,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.2,2.6.1.66	ko:K00814,ko:K14260	ko00220,ko00250,ko00290,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00220,map00250,map00290,map00710,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00171	R00258,R01215	RC00006,RC00008,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iNJ661.Rv0337c	Aminotran_1_2
TH2_k127_193290_1	289376.THEYE_A1944	2.874e-19	93.0	2CF4Z@1|root,330XB@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3617)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3617
TH2_k127_197708_10	269799.Gmet_0767	3.113e-08	55.0	COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,42MTV@68525|delta/epsilon subdivisions,2WKVP@28221|Deltaproteobacteria,43S8J@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Bacterial protein of unknown function (DUF853)	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853,DUF87
TH2_k127_197708_7	335543.Sfum_1392	5.972e-86	289.0	COG0655@1|root,COG0655@2|Bacteria,1RCJ8@1224|Proteobacteria,42QQT@68525|delta/epsilon subdivisions,2WMRW@28221|Deltaproteobacteria,2MQYY@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
TH2_k127_197708_1	589865.DaAHT2_1234	7.38e-147	493.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,42P8Y@68525|delta/epsilon subdivisions,2WJYW@28221|Deltaproteobacteria,2MIZ7@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Von Willebrand factor type A	-	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	VWA
TH2_k127_197708_2	1123393.KB891317_gene2368	1.504e-120	392.0	COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,2VHWI@28216|Betaproteobacteria,1KRY2@119069|Hydrogenophilales	119069|Hydrogenophilales	S	CbbQ/NirQ/NorQ C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5,CbbQ_C
TH2_k127_197708_11	1509403.GW12_26310	3.286e-08	61.0	COG4859@1|root,COG4859@2|Bacteria,1QWYN@1224|Proteobacteria,1T305@1236|Gammaproteobacteria,3NKA9@468|Moraxellaceae	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4262)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4262
TH2_k127_197708_12	65393.PCC7424_0391	5.238e-07	59.0	COG3577@1|root,COG3577@2|Bacteria,1G81F@1117|Cyanobacteria,3KHTG@43988|Cyanothece	1117|Cyanobacteria	S	gag-polyprotein putative aspartyl protease	-	-	-	ko:K06985	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	Asp_protease_2,gag-asp_proteas
TH2_k127_197708_9	1123070.KB899253_gene1085	1.462e-13	78.0	COG5642@1|root,COG5642@2|Bacteria,46XIK@74201|Verrucomicrobia,2IW0M@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Protein of unknown function (DUF2384)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2384
TH2_k127_197708_8	497965.Cyan7822_0110	7.121e-34	137.0	COG5654@1|root,COG5654@2|Bacteria,1G7GA@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM RES domain	-	-	-	-	-	-	-	-	-	-	-	-	RES
TH2_k127_197708_6	335543.Sfum_3445	5.561e-89	298.0	COG0664@1|root,COG0664@2|Bacteria,1MZZD@1224|Proteobacteria,42QUX@68525|delta/epsilon subdivisions,2WMWV@28221|Deltaproteobacteria,2MRAE@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	helix_turn_helix, cAMP Regulatory protein	fnr-1	-	-	ko:K01420,ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
TH2_k127_197708_5	706587.Desti_2518	2.643e-98	328.0	COG2221@1|root,COG2221@2|Bacteria,1R5F8@1224|Proteobacteria,42PB3@68525|delta/epsilon subdivisions,2WKJR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Nitrite and sulphite reductase 4Fe-4S	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6,Fer4_7,NIR_SIR,PCP_red
TH2_k127_197708_0	335543.Sfum_3446	3.648e-279	865.0	COG0369@1|root,COG1151@2|Bacteria,1N88B@1224|Proteobacteria,42M2C@68525|delta/epsilon subdivisions,2WIVE@28221|Deltaproteobacteria,2MQT5@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	-	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	-	Prismane
TH2_k127_197708_4	1121405.dsmv_1568	6.514e-99	330.0	COG1418@1|root,COG1418@2|Bacteria,1R60M@1224|Proteobacteria,42NFJ@68525|delta/epsilon subdivisions,2WIJT@28221|Deltaproteobacteria,2MJ3J@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM metal-dependent phosphohydrolase HD sub	-	-	-	-	-	-	-	-	-	-	-	-	HD
TH2_k127_197708_3	706587.Desti_2521	2.129e-100	332.0	COG1145@1|root,COG1145@2|Bacteria,1PW12@1224|Proteobacteria,42MZ9@68525|delta/epsilon subdivisions,2WN0W@28221|Deltaproteobacteria,2MR02@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6
TH2_k127_2081000_5	1210046.B277_14853	0.000449	46.0	COG0210@1|root,COG0210@2|Bacteria,2GM2E@201174|Actinobacteria,4FE4M@85021|Intrasporangiaceae	201174|Actinobacteria	L	Belongs to the helicase family. UvrD subfamily	uvrD2	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
TH2_k127_2081000_1	931276.Cspa_c40780	3.568e-151	492.0	COG0374@1|root,COG0374@2|Bacteria,1TQMW@1239|Firmicutes,248BB@186801|Clostridia,36F7N@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	hupL	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
TH2_k127_2081000_3	1089553.Tph_c06350	3.166e-68	242.0	COG1740@1|root,COG1740@2|Bacteria,1TZZD@1239|Firmicutes,2489B@186801|Clostridia,42FSN@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM hydrogenase (NiFe) small subunit (hydA)	-	-	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
TH2_k127_2081000_0	335543.Sfum_2666	0.0	1163.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WIXV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	GT	Pyruvate phosphate dikinase PEP	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
TH2_k127_2081000_4	443144.GM21_3474	2.496e-36	145.0	COG0526@1|root,COG0526@2|Bacteria,1N726@1224|Proteobacteria,42U61@68525|delta/epsilon subdivisions,2WQRF@28221|Deltaproteobacteria,43UYU@69541|Desulfuromonadales	28221|Deltaproteobacteria	CO	Thioredoxin-like	resA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TH2_k127_2081000_2	289376.THEYE_A0933	2.321e-147	470.0	COG0329@1|root,COG0329@2|Bacteria,3J0CF@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
TH2_k127_2131605_5	1123376.AUIU01000016_gene206	3.256e-112	377.0	COG0707@1|root,COG0707@2|Bacteria,3J0JS@40117|Nitrospirae	40117|Nitrospirae	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
TH2_k127_2131605_0	1123376.AUIU01000016_gene205	4.068e-173	554.0	COG0773@1|root,COG0773@2|Bacteria,3J0D5@40117|Nitrospirae	40117|Nitrospirae	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TH2_k127_2131605_8	1123376.AUIU01000016_gene204	1.93e-66	239.0	COG0812@1|root,COG0812@2|Bacteria,3J0Q1@40117|Nitrospirae	40117|Nitrospirae	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
TH2_k127_2131605_7	289376.THEYE_A1319	2.852e-102	342.0	COG1181@1|root,COG1181@2|Bacteria,3J0JM@40117|Nitrospirae	40117|Nitrospirae	F	Cell wall formation	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
TH2_k127_2131605_10	1123376.AUIU01000016_gene202	1.188e-41	163.0	COG1589@1|root,COG1589@2|Bacteria	2|Bacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly	ftsQ	GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0032506,GO:0040007,GO:0042802,GO:0043093,GO:0044085,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047	6.3.2.4	ko:K01921,ko:K03589,ko:K06438	ko00473,ko00550,ko01100,ko01502,ko04112,map00473,map00550,map01100,map01502,map04112	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	FtsQ,POTRA_1
TH2_k127_2131605_6	378806.STAUR_6257	1.402e-109	369.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,42MS2@68525|delta/epsilon subdivisions,2WIQ0@28221|Deltaproteobacteria,2YTZH@29|Myxococcales	28221|Deltaproteobacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
TH2_k127_2131605_1	1123376.AUIU01000016_gene200	8.419e-142	460.0	COG0206@1|root,COG0206@2|Bacteria,3J0D4@40117|Nitrospirae	40117|Nitrospirae	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
TH2_k127_2131605_2	1123376.AUIU01000016_gene199	2.37e-140	464.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TH2_k127_2131605_4	335543.Sfum_2333	1.481e-113	381.0	COG0534@1|root,COG0534@2|Bacteria,1NS6X@1224|Proteobacteria,42MWN@68525|delta/epsilon subdivisions,2WMPY@28221|Deltaproteobacteria,2MQVZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	MatE	-	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
TH2_k127_2131605_3	335543.Sfum_4051	4.876e-132	433.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,42M04@68525|delta/epsilon subdivisions,2WJJD@28221|Deltaproteobacteria	68525|delta/epsilon subdivisions	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1e
TH2_k127_2131605_9	331678.Cphamn1_1423	1.26e-65	228.0	COG1943@1|root,COG1943@2|Bacteria,1FEP9@1090|Chlorobi	1090|Chlorobi	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
TH2_k127_2131605_11	290317.Cpha266_1392	3.939e-16	82.0	COG1943@1|root,COG1943@2|Bacteria	290317.Cpha266_1392|-	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_2277374_1	589924.Ferp_0234	9.514e-20	102.0	COG1404@1|root,arCOG00702@2157|Archaea,2XSZR@28890|Euryarchaeota,2478R@183980|Archaeoglobi	28890|Euryarchaeota	O	Peptidase S8 and S53 subtilisin kexin sedolisin	-	-	3.4.21.62	ko:K01342,ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	PKD,Peptidase_S8
TH2_k127_2277374_0	679926.Mpet_1463	1.271e-126	433.0	COG1555@1|root,arCOG09405@2157|Archaea,2XXCV@28890|Euryarchaeota	28890|Euryarchaeota	L	PFAM Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
TH2_k127_2289416_6	1121448.DGI_1366	3.034e-25	104.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,43BJY@68525|delta/epsilon subdivisions,2WIWD@28221|Deltaproteobacteria,2M9AS@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Formate dehydrogenase, alpha subunit	fdnG-2	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
TH2_k127_2289416_4	795359.TOPB45_1449	6.316e-69	241.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,2GGUA@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
TH2_k127_2289416_3	243231.GSU1249	2.541e-101	346.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WM1A@28221|Deltaproteobacteria,43U1A@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9
TH2_k127_2289416_2	243231.GSU1250	3.269e-129	442.0	COG2204@1|root,COG2204@2|Bacteria,1PAPS@1224|Proteobacteria,42NMK@68525|delta/epsilon subdivisions,2WK6K@28221|Deltaproteobacteria,43U00@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH2_k127_2289416_1	289376.THEYE_A0613	4.356e-167	536.0	COG0683@1|root,COG0683@2|Bacteria	2|Bacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
TH2_k127_2289416_0	289376.THEYE_A0612	3.729e-182	595.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,PG_binding_1,Response_reg,dCache_1,sCache_3_2
TH2_k127_2289416_5	82654.Pse7367_0741	2.01e-27	113.0	COG0745@1|root,COG0745@2|Bacteria,1G5XG@1117|Cyanobacteria,1HB6Y@1150|Oscillatoriales	1117|Cyanobacteria	T	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TH2_k127_2399770_10	1123257.AUFV01000010_gene3345	4.05e-10	62.0	COG4389@1|root,COG4389@2|Bacteria,1MWEH@1224|Proteobacteria,1RPS7@1236|Gammaproteobacteria,1X9VM@135614|Xanthomonadales	135614|Xanthomonadales	L	Site-specific recombinase	-	-	-	-	-	-	-	-	-	-	-	-	SpecificRecomb
TH2_k127_2399770_1	909663.KI867150_gene2890	5.58e-118	396.0	COG3064@1|root,COG3064@2|Bacteria,1MXPS@1224|Proteobacteria,42PA3@68525|delta/epsilon subdivisions,2WM6X@28221|Deltaproteobacteria,2MQSC@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
TH2_k127_2399770_2	338966.Ppro_0418	6.276e-102	342.0	COG4786@1|root,COG4786@2|Bacteria,1MZXB@1224|Proteobacteria,42MTK@68525|delta/epsilon subdivisions,2WM8U@28221|Deltaproteobacteria,43T3T@69541|Desulfuromonadales	28221|Deltaproteobacteria	N	Protein of unknown function (DUF2950)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2950
TH2_k127_2399770_3	56780.SYN_00659	1.341e-61	228.0	COG0834@1|root,COG1073@1|root,COG0834@2|Bacteria,COG1073@2|Bacteria,1N3ZN@1224|Proteobacteria,42VWV@68525|delta/epsilon subdivisions	1224|Proteobacteria	ET	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	dCache_1
TH2_k127_2399770_4	667014.Thein_1022	4.382e-60	221.0	COG0535@1|root,COG0535@2|Bacteria,2GIGC@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_2399770_7	56780.SYN_01961	1.1e-35	144.0	COG3409@1|root,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_25,LysM,PG_binding_1,Peptidase_C14
TH2_k127_2399770_0	706587.Desti_1726	1.663e-161	515.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,42N4Z@68525|delta/epsilon subdivisions,2WIKW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07305,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
TH2_k127_2399770_5	404589.Anae109_3186	6.545e-58	207.0	COG3040@1|root,COG3040@2|Bacteria,1RIHP@1224|Proteobacteria,42SSW@68525|delta/epsilon subdivisions,2X6M9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Lipocalin-like domain	-	-	-	ko:K03098	-	-	-	-	ko00000,ko04147	-	-	-	Lipocalin_2
TH2_k127_2399770_9	941449.dsx2_0497	1.083e-21	106.0	COG1639@1|root,COG1639@2|Bacteria,1RAH3@1224|Proteobacteria,42PRF@68525|delta/epsilon subdivisions,2WMIN@28221|Deltaproteobacteria,2M912@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM Metal-dependent hydrolase HDOD	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
TH2_k127_2399770_6	269482.Bcep1808_0407	1.714e-51	191.0	COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,2VIBH@28216|Betaproteobacteria,1K1Z8@119060|Burkholderiaceae	28216|Betaproteobacteria	U	UPF0056 inner membrane protein	marC	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
TH2_k127_2399770_11	1002809.SSIL_0840	1.221e-09	63.0	COG0791@1|root,COG0791@2|Bacteria,1V9FW@1239|Firmicutes,4HISN@91061|Bacilli,26FSP@186818|Planococcaceae	91061|Bacilli	M	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
TH2_k127_2426548_17	1123376.AUIU01000001_gene796	7.172e-30	119.0	COG1260@1|root,COG1260@2|Bacteria	2|Bacteria	I	inositol-3-phosphate synthase activity	ino1	GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
TH2_k127_2426548_8	289376.THEYE_A1393	1.166e-58	212.0	COG0558@1|root,COG0558@2|Bacteria	2|Bacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA1	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf,DUF4833
TH2_k127_2426548_22	316067.Geob_0829	0.0004867	48.0	COG4768@1|root,COG4768@2|Bacteria	2|Bacteria	S	Bacterial protein of unknown function (DUF948)	WQ51_05790	-	-	-	-	-	-	-	-	-	-	-	DUF948
TH2_k127_2426548_16	1123376.AUIU01000001_gene793	5.3e-31	124.0	COG4980@1|root,COG4980@2|Bacteria,3J1B3@40117|Nitrospirae	40117|Nitrospirae	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	YtxH
TH2_k127_2426548_18	1123376.AUIU01000001_gene792	2.003e-29	121.0	COG0375@1|root,COG0375@2|Bacteria	2|Bacteria	S	nickel cation binding	hypA	-	-	ko:K04651,ko:K19640	-	-	-	-	ko00000,ko02022,ko03110	-	-	-	HypA
TH2_k127_2426548_3	1123376.AUIU01000001_gene791	2.354e-95	316.0	COG0378@1|root,COG0378@2|Bacteria,3J128@40117|Nitrospirae	40117|Nitrospirae	KO	CobW/HypB/UreG, nucleotide-binding domain	hypB	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
TH2_k127_2426548_11	1123376.AUIU01000001_gene790	3.029e-49	183.0	COG0590@1|root,COG0590@2|Bacteria,3J0PE@40117|Nitrospirae	40117|Nitrospirae	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
TH2_k127_2426548_4	706587.Desti_4273	1.797e-92	314.0	COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,42P5B@68525|delta/epsilon subdivisions,2WM02@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtap	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
TH2_k127_2426548_6	290318.Cvib_1509	2.504e-84	284.0	COG0503@1|root,COG0503@2|Bacteria,1FE1Q@1090|Chlorobi	1090|Chlorobi	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
TH2_k127_2426548_13	443143.GM18_2708	7.344e-42	156.0	2D7FD@1|root,32TNY@2|Bacteria,1NAHU@1224|Proteobacteria,42VAC@68525|delta/epsilon subdivisions,2WR6Q@28221|Deltaproteobacteria,43VVN@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1992)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1992
TH2_k127_2426548_2	439235.Dalk_2354	1.416e-100	348.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,42PSQ@68525|delta/epsilon subdivisions,2WKDY@28221|Deltaproteobacteria,2MK85@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2
TH2_k127_2426548_10	1123376.AUIU01000011_gene894	6.318e-53	188.0	COG3118@1|root,COG3118@2|Bacteria,3J0P6@40117|Nitrospirae	40117|Nitrospirae	O	Thioredoxin-like domain	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
TH2_k127_2426548_15	511051.CSE_09940	3.338e-32	134.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	resA	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Thioredoxin_8
TH2_k127_2426548_1	289376.THEYE_A1924	1.786e-200	638.0	COG0541@1|root,COG0541@2|Bacteria,3J0DT@40117|Nitrospirae	40117|Nitrospirae	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
TH2_k127_2426548_19	289376.THEYE_A0818	4.03e-27	112.0	COG0228@1|root,COG0228@2|Bacteria,3J0UI@40117|Nitrospirae	40117|Nitrospirae	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
TH2_k127_2426548_14	1089553.Tph_c10250	9.808e-33	134.0	COG0806@1|root,COG0806@2|Bacteria,1V6HD@1239|Firmicutes,24I1G@186801|Clostridia,42GTM@68295|Thermoanaerobacterales	186801|Clostridia	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
TH2_k127_2426548_5	997346.HMPREF9374_0878	1.867e-87	299.0	COG0336@1|root,COG0336@2|Bacteria,1TPBV@1239|Firmicutes,4HBFV@91061|Bacilli,27BNR@186824|Thermoactinomycetaceae	91061|Bacilli	J	tRNA (Guanine-1)-methyltransferase	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
TH2_k127_2426548_12	1123376.AUIU01000012_gene1339	4.491e-43	161.0	COG0335@1|root,COG0335@2|Bacteria,3J0MJ@40117|Nitrospirae	40117|Nitrospirae	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
TH2_k127_2426548_7	398767.Glov_2456	1.388e-60	218.0	COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,42REG@68525|delta/epsilon subdivisions,2WNK2@28221|Deltaproteobacteria,43SXH@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DUF208,RNase_HII
TH2_k127_2426548_9	404589.Anae109_2248	4.68e-54	197.0	COG1321@1|root,COG1918@1|root,COG1321@2|Bacteria,COG1918@2|Bacteria,1N3ZM@1224|Proteobacteria,42TUU@68525|delta/epsilon subdivisions,2WQ8Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KP	PFAM iron dependent repressor	ideR	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,FeoA
TH2_k127_2426548_0	1123376.AUIU01000012_gene1341	2.202e-259	823.0	COG0068@1|root,COG0068@2|Bacteria,3J0WS@40117|Nitrospirae	40117|Nitrospirae	O	Telomere recombination	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
TH2_k127_2426548_20	1038869.AXAN01000001_gene3830	7.644e-18	83.0	COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,2VJDB@28216|Betaproteobacteria,1K2QW@119060|Burkholderiaceae	28216|Betaproteobacteria	M	PFAM NAD-dependent epimerase dehydratase	-	-	4.1.1.35,4.2.1.46,5.1.3.2,5.1.3.7	ko:K01710,ko:K01784,ko:K02473,ko:K08678	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R00418,R01384,R02984,R06513	RC00289,RC00402,RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
TH2_k127_2496888_2	335543.Sfum_0735	6.862e-63	222.0	COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,SBP_bac_3
TH2_k127_2496888_0	1123376.AUIU01000018_gene4	3.887e-97	320.0	COG0717@1|root,COG0717@2|Bacteria	2|Bacteria	F	dUTP biosynthetic process	dcd	GO:0003674,GO:0003824,GO:0006139,GO:0006220,GO:0006244,GO:0006253,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008829,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009166,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009223,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046065,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
TH2_k127_2496888_1	635013.TherJR_1827	4.283e-65	232.0	COG0284@1|root,COG0284@2|Bacteria,1TPPH@1239|Firmicutes,24DII@186801|Clostridia,261JP@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
TH2_k127_2496888_4	246200.SPO3316a	3.651e-26	115.0	COG3871@1|root,COG3871@2|Bacteria	2|Bacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TH2_k127_2496888_3	522306.CAP2UW1_2609	1.42e-53	193.0	COG1192@1|root,COG1357@1|root,COG1787@1|root,COG2319@1|root,COG5635@1|root,COG1192@2|Bacteria,COG1357@2|Bacteria,COG1787@2|Bacteria,COG2319@2|Bacteria,COG5635@2|Bacteria,1MWJA@1224|Proteobacteria,2VI8Q@28216|Betaproteobacteria	28216|Betaproteobacteria	V	WD40 repeats	-	-	-	-	-	-	-	-	-	-	-	-	NACHT,Pentapeptide,WD40
TH2_k127_2682787_0	269799.Gmet_1992	3.966e-201	637.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42Q6R@68525|delta/epsilon subdivisions,2WJN4@28221|Deltaproteobacteria,43TK0@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Domains REC, sigma54 interaction, HTH8	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH2_k127_2682787_1	338966.Ppro_2542	1.433e-20	100.0	2EFX2@1|root,339PA@2|Bacteria,1NGKD@1224|Proteobacteria	1224|Proteobacteria	S	PEP-CTERM motif	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
TH2_k127_2746802_0	159087.Daro_2223	2.618e-172	548.0	COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,2VMP0@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Pfam Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
TH2_k127_2746802_4	443143.GM18_1407	2.157e-13	74.0	2EQIW@1|root,33I4X@2|Bacteria,1P5T0@1224|Proteobacteria,432D5@68525|delta/epsilon subdivisions,2WX86@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_2746802_1	525897.Dbac_2067	3.903e-77	263.0	COG0432@1|root,COG0432@2|Bacteria,1RA5G@1224|Proteobacteria,42QZ8@68525|delta/epsilon subdivisions,2WMV9@28221|Deltaproteobacteria,2MB2S@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
TH2_k127_2746802_2	243231.GSU3131	1.717e-58	233.0	COG2911@1|root,COG2982@1|root,COG2911@2|Bacteria,COG2982@2|Bacteria,1NSFI@1224|Proteobacteria,42YB5@68525|delta/epsilon subdivisions	1224|Proteobacteria	M	Protein involved in outer membrane biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_2746802_3	269799.Gmet_0357	2.524e-44	170.0	COG3784@1|root,COG3784@2|Bacteria,1Q1FT@1224|Proteobacteria,43788@68525|delta/epsilon subdivisions,2X9VZ@28221|Deltaproteobacteria,43U2G@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1318)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1318
TH2_k127_2746802_5	289376.THEYE_A1749	5.702e-06	51.0	COG1371@1|root,COG1371@2|Bacteria	2|Bacteria	J	PFAM Archease protein family (DUF101 UPF0211)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
TH2_k127_2815694_6	179408.Osc7112_2266	0.0002086	51.0	COG2199@1|root,COG2202@1|root,COG2203@1|root,COG3829@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria,COG3829@2|Bacteria,1G3Z1@1117|Cyanobacteria,1HEI8@1150|Oscillatoriales	1117|Cyanobacteria	KT	Diguanylate cyclase with PAS PAC and GAF sensors	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_3,PAS_9
TH2_k127_2815694_3	456442.Mboo_1006	2.034e-42	169.0	COG3503@1|root,arCOG04370@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF1624)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624
TH2_k127_2815694_2	289376.THEYE_A0548	1.111e-46	180.0	COG0251@1|root,COG0251@2|Bacteria,3J144@40117|Nitrospirae	40117|Nitrospirae	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
TH2_k127_2815694_0	289376.THEYE_A0867	7.129e-222	693.0	COG0065@1|root,COG0065@2|Bacteria,3J0IH@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
TH2_k127_2815694_4	1397693.KK211187_gene44	9.414e-41	159.0	COG0125@1|root,COG0125@2|Bacteria,1V1HE@1239|Firmicutes,4HGWR@91061|Bacilli,3WEKQ@539002|Bacillales incertae sedis	91061|Bacilli	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS02535	Thymidylate_kin
TH2_k127_2815694_5	338966.Ppro_3076	1.096e-19	93.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2WQ7I@28221|Deltaproteobacteria,43UXA@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Hsp20/alpha crystallin family	hspA-1	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
TH2_k127_2815694_1	289376.THEYE_A1394	1.183e-162	517.0	COG1260@1|root,COG1260@2|Bacteria	2|Bacteria	I	inositol-3-phosphate synthase activity	ino1	GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
TH2_k127_2866048_13	1502851.FG93_00043	2.31e-05	59.0	COG1404@1|root,COG2931@1|root,COG4932@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria,COG4932@2|Bacteria,1QYHZ@1224|Proteobacteria,2UHT4@28211|Alphaproteobacteria,3K04W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	SdrD_B
TH2_k127_2866048_10	1463920.JOGB01000064_gene4352	2.017e-14	89.0	COG2931@1|root,COG3291@1|root,COG4409@1|root,COG2931@2|Bacteria,COG3291@2|Bacteria,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	ASH,Big_3_2,F5_F8_type_C,HemolysinCabind,SBBP
TH2_k127_2866048_0	1056820.KB900671_gene2460	0.0	1292.0	COG1361@1|root,COG2885@1|root,COG3266@1|root,COG3637@1|root,COG1361@2|Bacteria,COG2885@2|Bacteria,COG3266@2|Bacteria,COG3637@2|Bacteria,1QVSF@1224|Proteobacteria,1T46K@1236|Gammaproteobacteria,2PQ95@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,OmpA,OmpA_membrane
TH2_k127_2866048_11	1265313.HRUBRA_02005	5.409e-14	81.0	29HMV@1|root,304J5@2|Bacteria,1R3GZ@1224|Proteobacteria,1T67V@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Transmembrane exosortase (Exosortase_EpsH)	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
TH2_k127_2866048_3	338966.Ppro_1169	2.284e-128	428.0	COG1652@1|root,COG4254@1|root,COG1652@2|Bacteria,COG4254@2|Bacteria,1NKA2@1224|Proteobacteria,43B6B@68525|delta/epsilon subdivisions,2X6JV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR,LysM
TH2_k127_2866048_4	1123376.AUIU01000011_gene833	9.29e-83	287.0	COG0795@1|root,COG0795@2|Bacteria,3J0S0@40117|Nitrospirae	40117|Nitrospirae	S	Predicted permease YjgP/YjgQ family	-	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
TH2_k127_2866048_6	289376.THEYE_A1951	1.549e-67	243.0	COG0795@1|root,COG0795@2|Bacteria,3J0QQ@40117|Nitrospirae	40117|Nitrospirae	S	Predicted permease YjgP/YjgQ family	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
TH2_k127_2866048_5	926692.AZYG01000034_gene2406	7.387e-77	267.0	COG0115@1|root,COG0115@2|Bacteria,1TPY2@1239|Firmicutes,25CC3@186801|Clostridia,3WAHQ@53433|Halanaerobiales	186801|Clostridia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
TH2_k127_2866048_8	1321786.HMPREF1992_01245	1.05e-25	109.0	COG0792@1|root,COG0792@2|Bacteria,1VFHQ@1239|Firmicutes,4H5MB@909932|Negativicutes	909932|Negativicutes	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
TH2_k127_2866048_7	1123376.AUIU01000011_gene836	1.38e-44	168.0	COG1658@1|root,COG1658@2|Bacteria	2|Bacteria	L	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step	rnmV	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043822,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360	3.1.26.8	ko:K05985,ko:K07476	-	-	-	-	ko00000,ko01000	-	-	-	DUF4093,Toprim,Toprim_4
TH2_k127_2866048_12	357808.RoseRS_2086	4.9e-08	59.0	COG1522@1|root,COG1522@2|Bacteria,2G7CK@200795|Chloroflexi,377PM@32061|Chloroflexia	32061|Chloroflexia	K	PFAM regulatory protein AsnC Lrp family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
TH2_k127_2866048_1	944481.JAFP01000001_gene254	1.476e-228	721.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42P0M@68525|delta/epsilon subdivisions,2WJMC@28221|Deltaproteobacteria,2M6V7@213113|Desulfurellales	28221|Deltaproteobacteria	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
TH2_k127_2866048_2	574087.Acear_1673	5.489e-146	506.0	COG1196@1|root,COG1196@2|Bacteria,1TPJV@1239|Firmicutes,249F4@186801|Clostridia,3WAB0@53433|Halanaerobiales	186801|Clostridia	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
TH2_k127_2866048_9	1249480.B649_03065	1.333e-23	105.0	2AJ4C@1|root,319NV@2|Bacteria,1Q3D8@1224|Proteobacteria,431S6@68525|delta/epsilon subdivisions,2YS5U@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_2869633_13	237368.SCABRO_02198	2.893e-26	112.0	COG4244@1|root,COG4244@2|Bacteria	2|Bacteria	E	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	Cyt-b5,DUF2231,Fn3_assoc,PSCyt1,PSCyt2,PSD1
TH2_k127_2869633_0	484770.UFO1_0990	1.286e-157	507.0	COG0436@1|root,COG0436@2|Bacteria,1TQP0@1239|Firmicutes,4H2IC@909932|Negativicutes	909932|Negativicutes	E	Aminotransferase	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
TH2_k127_2869633_12	926562.Oweho_0578	3.818e-34	138.0	COG1047@1|root,COG1047@2|Bacteria,4NM29@976|Bacteroidetes,1I1ZU@117743|Flavobacteriia,2PB7Q@246874|Cryomorphaceae	976|Bacteroidetes	O	FKBP-type peptidyl-prolyl cis-trans isomerase	slyD	-	5.2.1.8	ko:K01802,ko:K03774,ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
TH2_k127_2869633_10	754476.Q7A_1679	2.672e-45	173.0	COG0421@1|root,COG0421@2|Bacteria,1RBWW@1224|Proteobacteria,1S3KK@1236|Gammaproteobacteria,46150@72273|Thiotrichales	72273|Thiotrichales	E	Spermidine synthase	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
TH2_k127_2869633_14	1121423.JONT01000001_gene2137	3.704e-18	96.0	COG0583@1|root,COG0583@2|Bacteria,1TSA6@1239|Firmicutes,24BM8@186801|Clostridia,261QC@186807|Peptococcaceae	186801|Clostridia	K	Transcriptional regulator, LysR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TH2_k127_2869633_8	395019.Bmul_3029	2.335e-63	240.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2VHPK@28216|Betaproteobacteria,1K124@119060|Burkholderiaceae	28216|Betaproteobacteria	M	lytic transglycosylase	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,SLT_L
TH2_k127_2869633_1	1121448.DGI_3104	8.556e-155	512.0	COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,42MA5@68525|delta/epsilon subdivisions,2WJGZ@28221|Deltaproteobacteria,2M9Y5@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
TH2_k127_2869633_9	192952.MM_3075	3.237e-46	172.0	COG1611@1|root,arCOG02431@2157|Archaea,2XXTK@28890|Euryarchaeota,2N9VX@224756|Methanomicrobia	224756|Methanomicrobia	S	Rossmann fold nucleotide-binding protein	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
TH2_k127_2869633_2	867903.ThesuDRAFT_01687	1.436e-116	383.0	COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,2497G@186801|Clostridia,3WCW0@538999|Clostridiales incertae sedis	186801|Clostridia	E	Pyridoxal-phosphate dependent enzyme	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TH2_k127_2869633_4	289376.THEYE_A1541	7.175e-107	352.0	COG0052@1|root,COG0052@2|Bacteria,3J0G9@40117|Nitrospirae	40117|Nitrospirae	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
TH2_k127_2869633_6	1123376.AUIU01000016_gene310	2.115e-85	286.0	COG0264@1|root,COG0264@2|Bacteria,3J0I2@40117|Nitrospirae	40117|Nitrospirae	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
TH2_k127_2869633_3	1123376.AUIU01000016_gene309	6.865e-107	352.0	COG0528@1|root,COG0528@2|Bacteria,3J0BE@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
TH2_k127_2869633_7	1123376.AUIU01000016_gene308	3.871e-73	250.0	COG0233@1|root,COG0233@2|Bacteria,3J0KJ@40117|Nitrospirae	40117|Nitrospirae	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
TH2_k127_2869633_11	289376.THEYE_A1545	3.132e-43	161.0	COG1734@1|root,COG1734@2|Bacteria,3J0R1@40117|Nitrospirae	40117|Nitrospirae	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
TH2_k127_2869633_5	909663.KI867150_gene27	1.816e-91	306.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,42N38@68525|delta/epsilon subdivisions,2WK56@28221|Deltaproteobacteria,2MS0T@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Di-haem cytochrome c peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG,Cytochrom_C
TH2_k127_2983440_7	1123376.AUIU01000016_gene338	1.208e-99	338.0	COG1503@1|root,COG1503@2|Bacteria	2|Bacteria	J	translation release factor activity	yocB	GO:0001666,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008150,GO:0009628,GO:0016020,GO:0030312,GO:0036293,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070482,GO:0071944	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	-
TH2_k127_2983440_4	909663.KI867150_gene1791	2.041e-103	347.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,42N2T@68525|delta/epsilon subdivisions,2WMYV@28221|Deltaproteobacteria,2MRZQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TH2_k127_2983440_9	562970.Btus_0217	1.202e-42	169.0	COG2071@1|root,COG2071@2|Bacteria,1V1KC@1239|Firmicutes,4HI59@91061|Bacilli,278C2@186823|Alicyclobacillaceae	91061|Bacilli	S	Peptidase C26	-	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
TH2_k127_2983440_1	1499967.BAYZ01000028_gene1366	1.291e-133	443.0	COG3653@1|root,COG3653@2|Bacteria,2NNQ0@2323|unclassified Bacteria	2|Bacteria	Q	Amidohydrolase family	dan	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
TH2_k127_2983440_5	289376.THEYE_A1467	1.473e-102	349.0	COG0860@1|root,COG0860@2|Bacteria,3J0MT@40117|Nitrospirae	40117|Nitrospirae	M	Ami_3	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
TH2_k127_2983440_10	289376.THEYE_A1468	1.955e-25	107.0	COG0694@1|root,COG0694@2|Bacteria	2|Bacteria	O	iron-sulfur cluster assembly	yutI	-	-	-	-	-	-	-	-	-	-	-	NifU
TH2_k127_2983440_2	224324.aq_2110	2.757e-112	370.0	COG0123@1|root,COG0123@2|Bacteria,2G3QH@200783|Aquificae	200783|Aquificae	BQ	PFAM histone deacetylase superfamily	acuC2	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
TH2_k127_2983440_3	56780.SYN_00141	8.788e-111	371.0	COG0235@1|root,COG0235@2|Bacteria,1N84G@1224|Proteobacteria,42RVW@68525|delta/epsilon subdivisions	1224|Proteobacteria	G	PFAM class II aldolase adducin family protein	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
TH2_k127_2983440_0	1121918.ARWE01000001_gene3568	2.596e-187	602.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
TH2_k127_2983440_8	903818.KI912269_gene490	7.207e-98	336.0	COG0773@1|root,COG1376@1|root,COG0773@2|Bacteria,COG1376@2|Bacteria,3Y304@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the MurCDEF family	-	-	-	-	-	-	-	-	-	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M,YkuD
TH2_k127_2983440_11	483219.LILAB_19350	3.181e-19	98.0	COG3031@1|root,COG3031@2|Bacteria,1RFDB@1224|Proteobacteria,42WP0@68525|delta/epsilon subdivisions,2X6P7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	General secretion pathway protein C	-	-	-	ko:K02452	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSC
TH2_k127_2983440_6	316067.Geob_0896	6.554e-100	341.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,42M9I@68525|delta/epsilon subdivisions,2WK1H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	Type II and III secretion system protein	gspD	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
TH2_k127_3125140_34	289376.THEYE_A0972	1.67e-10	64.0	COG0483@1|root,COG0483@2|Bacteria	2|Bacteria	G	inositol monophosphate 1-phosphatase activity	suhB	-	3.1.3.25,3.1.3.7	ko:K01082,ko:K01092	ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070	M00131	R00188,R00508,R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	Inositol_P
TH2_k127_3125140_5	1123376.AUIU01000004_gene1171	1.598e-103	347.0	COG0079@1|root,COG0079@2|Bacteria,3J11B@40117|Nitrospirae	40117|Nitrospirae	E	Aminotransferase class I and II	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TH2_k127_3125140_15	1121405.dsmv_1022	6.258e-62	226.0	COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,42NIV@68525|delta/epsilon subdivisions,2WNA4@28221|Deltaproteobacteria,2MJMY@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM Imidazoleglycerol-phosphate dehydratase	hisB	GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
TH2_k127_3125140_2	289376.THEYE_A0571	7.853e-123	405.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,3J0VG@40117|Nitrospirae	40117|Nitrospirae	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
TH2_k127_3125140_19	289376.THEYE_A1420	2.889e-48	177.0	COG0203@1|root,COG0203@2|Bacteria,3J0TE@40117|Nitrospirae	40117|Nitrospirae	J	Ribosomal protein L17	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
TH2_k127_3125140_3	330214.NIDE1339	1.666e-111	370.0	COG0202@1|root,COG0202@2|Bacteria,3J0AR@40117|Nitrospirae	40117|Nitrospirae	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
TH2_k127_3125140_9	289376.THEYE_A1422	6.543e-85	289.0	COG0522@1|root,COG0522@2|Bacteria,3J0IC@40117|Nitrospirae	40117|Nitrospirae	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
TH2_k127_3125140_17	321327.CYA_1452	2.961e-54	196.0	COG0100@1|root,COG0100@2|Bacteria,1G4Z1@1117|Cyanobacteria,1H08C@1129|Synechococcus	1117|Cyanobacteria	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
TH2_k127_3125140_18	289376.THEYE_A1424	3.919e-54	192.0	COG0099@1|root,COG0099@2|Bacteria,3J0Q5@40117|Nitrospirae	40117|Nitrospirae	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
TH2_k127_3125140_33	1125863.JAFN01000001_gene3318	1.722e-13	70.0	COG0257@1|root,COG0257@2|Bacteria,1NGEI@1224|Proteobacteria,42WXD@68525|delta/epsilon subdivisions,2WSYK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
TH2_k127_3125140_27	1345697.M493_00990	1.604e-33	129.0	COG0361@1|root,COG0361@2|Bacteria,1V9ZK@1239|Firmicutes,4HKF4@91061|Bacilli,1WGUD@129337|Geobacillus	91061|Bacilli	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
TH2_k127_3125140_6	373903.Hore_01380	2.315e-100	332.0	COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,248I8@186801|Clostridia,3WA6N@53433|Halanaerobiales	186801|Clostridia	J	TIGRFAM methionine aminopeptidase, type I	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
TH2_k127_3125140_0	289376.THEYE_A1427	1.319e-133	429.0	COG0201@1|root,COG0201@2|Bacteria,3J0C0@40117|Nitrospirae	40117|Nitrospirae	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
TH2_k127_3125140_11	289376.THEYE_A1427	1.862e-79	269.0	COG0201@1|root,COG0201@2|Bacteria,3J0C0@40117|Nitrospirae	40117|Nitrospirae	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
TH2_k127_3125140_22	1123376.AUIU01000005_gene1215	1.741e-44	168.0	COG0200@1|root,COG0200@2|Bacteria,3J0PY@40117|Nitrospirae	40117|Nitrospirae	J	binds to the 23S rRNA	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
TH2_k127_3125140_13	289376.THEYE_A1429	4.701e-67	232.0	COG0098@1|root,COG0098@2|Bacteria,3J0M3@40117|Nitrospirae	40117|Nitrospirae	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
TH2_k127_3125140_25	289376.THEYE_A1430	4.884e-39	149.0	COG0256@1|root,COG0256@2|Bacteria,3J0QF@40117|Nitrospirae	40117|Nitrospirae	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
TH2_k127_3125140_14	289376.THEYE_A1431	1.45e-66	231.0	COG0097@1|root,COG0097@2|Bacteria,3J0JB@40117|Nitrospirae	40117|Nitrospirae	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
TH2_k127_3125140_21	1132442.KB889752_gene3468	1.016e-45	168.0	COG0096@1|root,COG0096@2|Bacteria,1V3KK@1239|Firmicutes,4HH32@91061|Bacilli,1ZFMC@1386|Bacillus	91061|Bacilli	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
TH2_k127_3125140_30	944481.JAFP01000001_gene1466	1.273e-23	103.0	COG0199@1|root,COG0199@2|Bacteria,1PDMJ@1224|Proteobacteria,42VCE@68525|delta/epsilon subdivisions,2WR7W@28221|Deltaproteobacteria,2M7GG@213113|Desulfurellales	28221|Deltaproteobacteria	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
TH2_k127_3125140_7	289376.THEYE_A1434	1.633e-87	297.0	COG0094@1|root,COG0094@2|Bacteria,3J0HN@40117|Nitrospirae	40117|Nitrospirae	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
TH2_k127_3125140_23	1123376.AUIU01000005_gene1209	4.178e-41	153.0	COG0198@1|root,COG0198@2|Bacteria,3J0VK@40117|Nitrospirae	40117|Nitrospirae	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
TH2_k127_3125140_16	289376.THEYE_A1436	5.538e-57	201.0	COG0093@1|root,COG0093@2|Bacteria,3J0JD@40117|Nitrospirae	40117|Nitrospirae	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
TH2_k127_3125140_28	1123376.AUIU01000005_gene1207	6.1e-30	121.0	COG0186@1|root,COG0186@2|Bacteria,3J0TQ@40117|Nitrospirae	40117|Nitrospirae	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
TH2_k127_3125140_31	289376.THEYE_A1438	3.822e-16	81.0	COG0255@1|root,COG0255@2|Bacteria	2|Bacteria	J	Belongs to the universal ribosomal protein uL29 family	rpmC	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
TH2_k127_3125140_12	289376.THEYE_A1439	6.296e-72	247.0	COG0197@1|root,COG0197@2|Bacteria,3J0H7@40117|Nitrospirae	40117|Nitrospirae	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
TH2_k127_3125140_4	289376.THEYE_A1440	3.47e-105	346.0	COG0092@1|root,COG0092@2|Bacteria,3J0AP@40117|Nitrospirae	40117|Nitrospirae	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
TH2_k127_3125140_26	1123376.AUIU01000005_gene1203	9.912e-39	147.0	COG0091@1|root,COG0091@2|Bacteria,3J0RZ@40117|Nitrospirae	40117|Nitrospirae	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
TH2_k127_3125140_24	1123376.AUIU01000005_gene1202	5.799e-41	153.0	COG0185@1|root,COG0185@2|Bacteria,3J0MU@40117|Nitrospirae	40117|Nitrospirae	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
TH2_k127_3125140_1	289376.THEYE_A1443	1.347e-123	401.0	COG0090@1|root,COG0090@2|Bacteria,3J0BX@40117|Nitrospirae	40117|Nitrospirae	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
TH2_k127_3125140_29	1123376.AUIU01000005_gene1200	1.316e-28	117.0	COG0089@1|root,COG0089@2|Bacteria,3J0TP@40117|Nitrospirae	40117|Nitrospirae	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
TH2_k127_3125140_10	289376.THEYE_A1445	8.382e-80	272.0	COG0088@1|root,COG0088@2|Bacteria,3J15W@40117|Nitrospirae	40117|Nitrospirae	J	Ribosomal protein L4/L1 family	rplD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
TH2_k127_3125140_8	1123376.AUIU01000005_gene1198	1.851e-86	291.0	COG0087@1|root,COG0087@2|Bacteria,3J0HP@40117|Nitrospirae	40117|Nitrospirae	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
TH2_k127_3125140_20	1207063.P24_12766	1.166e-46	171.0	COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,2U95D@28211|Alphaproteobacteria,2JST1@204441|Rhodospirillales	204441|Rhodospirillales	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
TH2_k127_3125140_32	1379281.AVAG01000108_gene241	4.67e-15	74.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2WJ2B@28221|Deltaproteobacteria,2M88A@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
TH2_k127_315085_0	1041930.Mtc_2416	7.2e-223	706.0	COG2217@1|root,arCOG02763@1|root,arCOG01576@2157|Archaea,arCOG02763@2157|Archaea,2XT3T@28890|Euryarchaeota,2N94W@224756|Methanomicrobia	224756|Methanomicrobia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
TH2_k127_315085_2	944480.ATUV01000002_gene291	4.788e-200	637.0	COG0595@1|root,COG0595@2|Bacteria,1MUGV@1224|Proteobacteria,42M65@68525|delta/epsilon subdivisions,2WIQ9@28221|Deltaproteobacteria,2M6H6@213113|Desulfurellales	28221|Deltaproteobacteria	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
TH2_k127_315085_3	1123376.AUIU01000015_gene489	5.187e-75	260.0	COG1968@1|root,COG1968@2|Bacteria,3J0S7@40117|Nitrospirae	40117|Nitrospirae	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP)	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
TH2_k127_315085_1	1123376.AUIU01000015_gene490	1.741e-207	672.0	COG1674@1|root,COG1674@2|Bacteria,3J0BQ@40117|Nitrospirae	40117|Nitrospirae	D	Ftsk_gamma	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
TH2_k127_315085_5	1125863.JAFN01000001_gene3584	3.784e-14	83.0	COG2834@1|root,COG2834@2|Bacteria,1PDTV@1224|Proteobacteria,42TAB@68525|delta/epsilon subdivisions,2WPXY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
TH2_k127_315085_4	871963.Desdi_0737	2.303e-17	86.0	COG0500@1|root,COG2226@2|Bacteria,1TT7G@1239|Firmicutes,24E44@186801|Clostridia,263FJ@186807|Peptococcaceae	186801|Clostridia	Q	NOG31153 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3348394_40	1385517.N800_00455	4.417e-06	59.0	COG1404@1|root,COG4447@1|root,COG1404@2|Bacteria,COG4447@2|Bacteria,1MVIT@1224|Proteobacteria	1224|Proteobacteria	MU	K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
TH2_k127_3348394_22	316274.Haur_2192	2.098e-54	206.0	COG5295@1|root,COG5295@2|Bacteria,2GB82@200795|Chloroflexi,377IZ@32061|Chloroflexia	32061|Chloroflexia	UW	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Pectinesterase
TH2_k127_3348394_36	1122947.FR7_0154	6.059e-20	104.0	COG0457@1|root,COG0457@2|Bacteria,1U4DH@1239|Firmicutes,4H5FH@909932|Negativicutes	909932|Negativicutes	S	PFAM Tetratricopeptide TPR_1 repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
TH2_k127_3348394_38	1002809.SSIL_0840	3.956e-08	64.0	COG0791@1|root,COG0791@2|Bacteria,1V9FW@1239|Firmicutes,4HISN@91061|Bacilli,26FSP@186818|Planococcaceae	91061|Bacilli	M	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
TH2_k127_3348394_23	247490.KSU1_B0116	4.186e-52	194.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3348394_12	443144.GM21_3607	1.715e-83	286.0	COG2875@1|root,COG2875@2|Bacteria,1MVYY@1224|Proteobacteria,42P88@68525|delta/epsilon subdivisions,2WMR1@28221|Deltaproteobacteria,43T6V@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase	cbiF	-	2.1.1.133,2.1.1.271	ko:K05936	ko00860,ko01100,map00860,map01100	-	R05181,R05810	RC00003,RC01294,RC02049	ko00000,ko00001,ko01000	-	-	-	CbiG_C,CbiG_N,TP_methylase
TH2_k127_3348394_15	316067.Geob_1852	6.362e-76	266.0	COG1418@1|root,COG1418@2|Bacteria,1RK7K@1224|Proteobacteria,42SRK@68525|delta/epsilon subdivisions,2WP5I@28221|Deltaproteobacteria,43UQH@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Metal-dependent phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HD
TH2_k127_3348394_19	589865.DaAHT2_1585	3.566e-64	227.0	COG2243@1|root,COG2243@2|Bacteria,1MV3G@1224|Proteobacteria,42MGC@68525|delta/epsilon subdivisions,2WM51@28221|Deltaproteobacteria,2MISM@213118|Desulfobacterales	28221|Deltaproteobacteria	H	TIGRFAM precorrin-2 C20-methyltransferase	cbiL	-	2.1.1.130,2.1.1.151	ko:K03394	ko00860,ko01100,map00860,map01100	-	R03948,R05808	RC00003,RC01035,RC01662	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_0482	TP_methylase
TH2_k127_3348394_13	161156.JQKW01000008_gene568	3.454e-83	293.0	COG2241@1|root,COG2242@1|root,COG2241@2|Bacteria,COG2242@2|Bacteria,2GHUJ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	-	-	2.1.1.132	ko:K00595	ko00860,ko01100,map00860,map01100	-	R05149	RC00003,RC01279	ko00000,ko00001,ko01000	-	-	-	Methyltransf_4,TP_methylase
TH2_k127_3348394_2	1283300.ATXB01000001_gene1756	2.622e-151	487.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RN3S@1236|Gammaproteobacteria,1XDRB@135618|Methylococcales	135618|Methylococcales	E	PFAM Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TH2_k127_3348394_11	1167006.UWK_03255	7.556e-86	298.0	COG1903@1|root,COG1903@2|Bacteria,1MXU3@1224|Proteobacteria,42N2R@68525|delta/epsilon subdivisions,2WJF4@28221|Deltaproteobacteria,2MI6Z@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A	cbiD	-	2.1.1.195	ko:K02188	ko00860,ko01100,map00860,map01100	-	R07773	RC00003,RC02051	ko00000,ko00001,ko01000	-	-	-	CbiD
TH2_k127_3348394_24	944479.JQLX01000013_gene1324	1.716e-51	190.0	COG2109@1|root,COG2109@2|Bacteria,1MUN6@1224|Proteobacteria,42RPD@68525|delta/epsilon subdivisions,2WNI0@28221|Deltaproteobacteria,2M6U3@213113|Desulfurellales	28221|Deltaproteobacteria	H	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
TH2_k127_3348394_4	243231.GSU3001	3.68e-116	394.0	COG1122@1|root,COG1122@2|Bacteria,1N5X0@1224|Proteobacteria,42R39@68525|delta/epsilon subdivisions,2WN10@28221|Deltaproteobacteria,43SJ8@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	part of an ABC transporter complex. Responsible for energy coupling to the transport system	cbiO	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
TH2_k127_3348394_16	243231.GSU3002	5.74e-75	261.0	COG0619@1|root,COG0619@2|Bacteria,1R4KM@1224|Proteobacteria,42WF5@68525|delta/epsilon subdivisions,2WSAH@28221|Deltaproteobacteria,43ST2@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ	cbiQ	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
TH2_k127_3348394_33	243231.GSU3004	4.192e-23	102.0	COG0310@1|root,COG0310@2|Bacteria,1NTQK@1224|Proteobacteria,42SA9@68525|delta/epsilon subdivisions,2WNVZ@28221|Deltaproteobacteria,43SN0@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import	cbiM	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM
TH2_k127_3348394_8	269799.Gmet_0472	2.329e-93	317.0	COG0310@1|root,COG0310@2|Bacteria,1NTQK@1224|Proteobacteria,42SA9@68525|delta/epsilon subdivisions,2WNVZ@28221|Deltaproteobacteria,43SN0@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import	cbiM	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM
TH2_k127_3348394_14	1123376.AUIU01000012_gene1369	1.601e-82	287.0	COG2082@1|root,COG2138@1|root,COG2082@2|Bacteria,COG2138@2|Bacteria,3J0MV@40117|Nitrospirae	40117|Nitrospirae	H	Precorrin-8X methylmutase	-	-	5.4.99.60,5.4.99.61	ko:K06042	ko00860,ko01100,map00860,map01100	-	R05177,R05814	RC01292,RC01980	ko00000,ko00001,ko01000	-	-	-	CbiC
TH2_k127_3348394_5	1121405.dsmv_0499	1.697e-114	391.0	COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,42M8T@68525|delta/epsilon subdivisions,2WIXE@28221|Deltaproteobacteria,2MIF0@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source	cbiA	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_0470	CPT,CbiA,GATase_3
TH2_k127_3348394_10	589865.DaAHT2_1591	4.253e-88	305.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,42NV6@68525|delta/epsilon subdivisions,2WIPB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Aminotransferase class I and II	cobD	-	4.1.1.81	ko:K04720	ko00860,map00860	-	R06530	RC00517	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_0487	Aminotran_1_2
TH2_k127_3348394_9	909663.KI867150_gene1698	1.458e-92	317.0	COG1270@1|root,COG1270@2|Bacteria,1MURM@1224|Proteobacteria,42PDX@68525|delta/epsilon subdivisions,2WKH4@28221|Deltaproteobacteria,2MQT0@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group	cobD	-	6.3.1.10	ko:K02227	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CobD_Cbib
TH2_k127_3348394_1	1123376.AUIU01000012_gene1365	1.651e-156	510.0	COG1492@1|root,COG1492@2|Bacteria,3J0F3@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation	cobQ	-	6.3.5.10	ko:K02232	ko00860,ko01100,map00860,map01100	M00122	R05225	RC00010,RC01302	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,CbiA,GATase_3
TH2_k127_3348394_17	589865.DaAHT2_1519	4.407e-71	256.0	COG0406@1|root,COG0406@2|Bacteria,1RHAT@1224|Proteobacteria,42SUD@68525|delta/epsilon subdivisions,2WP5H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM Phosphoglycerate mutase	cobC	-	3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
TH2_k127_3348394_30	161156.JQKW01000008_gene563	6.306e-36	148.0	COG0368@1|root,COG0368@2|Bacteria,2GI54@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	Cobalamin-5-phosphate synthase	-	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
TH2_k127_3348394_3	909663.KI867150_gene1700	1.749e-137	449.0	COG2038@1|root,COG2038@2|Bacteria,1MVAM@1224|Proteobacteria,42M3Z@68525|delta/epsilon subdivisions,2WJIR@28221|Deltaproteobacteria,2MQA3@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)	cobT	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008939,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000	-	-	-	DBI_PRT
TH2_k127_3348394_27	909663.KI867150_gene1701	3.267e-48	178.0	COG2087@1|root,COG2087@2|Bacteria,1RH0A@1224|Proteobacteria,42TMF@68525|delta/epsilon subdivisions,2WQNM@28221|Deltaproteobacteria,2MQK1@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate	cobU	-	2.7.1.156,2.7.7.62	ko:K02231	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	CobU
TH2_k127_3348394_7	289376.THEYE_A0069	2.661e-102	363.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,3J0VB@40117|Nitrospirae	40117|Nitrospirae	S	Competence protein	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,Lactamase_B
TH2_k127_3348394_0	289376.THEYE_A0046	2.813e-164	528.0	COG1109@1|root,COG1109@2|Bacteria,3J0E7@40117|Nitrospirae	40117|Nitrospirae	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TH2_k127_3348394_21	289376.THEYE_A0045	4.171e-56	204.0	COG4856@1|root,COG4856@2|Bacteria,3J1EE@40117|Nitrospirae	40117|Nitrospirae	S	YbbR-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
TH2_k127_3348394_6	289376.THEYE_A0044	5.783e-104	344.0	COG1624@1|root,COG1624@2|Bacteria,3J0XP@40117|Nitrospirae	40117|Nitrospirae	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
TH2_k127_3348394_29	289376.THEYE_A0043	2.898e-43	166.0	COG0760@1|root,COG0760@2|Bacteria,3J1BR@40117|Nitrospirae	40117|Nitrospirae	O	SurA N-terminal domain	-	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	SurA_N_3
TH2_k127_3348394_25	944481.JAFP01000001_gene881	6.874e-51	183.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,42M7Y@68525|delta/epsilon subdivisions,2WIRN@28221|Deltaproteobacteria,2M6G5@213113|Desulfurellales	28221|Deltaproteobacteria	E	Argininosuccinate lyase C-terminal	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1,NUDIX
TH2_k127_3348394_35	156889.Mmc1_0277	2.53e-20	93.0	COG1923@1|root,COG1923@2|Bacteria,1MZM1@1224|Proteobacteria,2UBTW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs	hfq	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006807,GO:0008150,GO:0008152,GO:0009399,GO:0071941,GO:0097159,GO:1901363	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
TH2_k127_3348394_34	1123376.AUIU01000018_gene47	2.248e-21	94.0	COG2331@1|root,COG2331@2|Bacteria	2|Bacteria	P	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
TH2_k127_3348394_18	1123376.AUIU01000002_gene1673	9.381e-65	224.0	COG0691@1|root,COG0691@2|Bacteria,3J0Q4@40117|Nitrospirae	40117|Nitrospirae	O	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
TH2_k127_3348394_26	1123261.AXDW01000008_gene971	7.058e-50	182.0	COG0622@1|root,COG0622@2|Bacteria,1RGUN@1224|Proteobacteria,1S69D@1236|Gammaproteobacteria,1XC2C@135614|Xanthomonadales	135614|Xanthomonadales	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
TH2_k127_3348394_20	289376.THEYE_A0959	1.451e-59	213.0	COG0811@1|root,COG0811@2|Bacteria,3J0PX@40117|Nitrospirae	40117|Nitrospirae	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
TH2_k127_3348394_28	289376.THEYE_A0958	4.699e-44	164.0	COG0848@1|root,COG0848@2|Bacteria,3J0T6@40117|Nitrospirae	40117|Nitrospirae	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	ExbD
TH2_k127_3348394_37	289376.THEYE_A0957	5.292e-19	96.0	COG0810@1|root,COG0810@2|Bacteria	2|Bacteria	M	energy transducer activity	tolA	-	-	ko:K03646,ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1,2.C.1.2	-	-	TonB_2
TH2_k127_3348394_32	1122214.AQWH01000004_gene917	9.672e-30	130.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2TR03@28211|Alphaproteobacteria,2PJ9S@255475|Aurantimonadaceae	28211|Alphaproteobacteria	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
TH2_k127_3401855_5	1131269.AQVV01000001_gene1328	1.739e-50	195.0	COG1191@1|root,COG1191@2|Bacteria	2|Bacteria	K	sigma factor activity	fliA	-	-	ko:K02405,ko:K03093	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
TH2_k127_3401855_1	338963.Pcar_1160	9.419e-82	282.0	COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,42PF7@68525|delta/epsilon subdivisions,2WJB5@28221|Deltaproteobacteria,43TV1@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Cellulose biosynthesis protein BcsQ	flhG	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	AAA_31,CbiA,ParA
TH2_k127_3401855_6	886293.Sinac_7410	2.449e-49	190.0	COG1419@1|root,COG1419@2|Bacteria,2IYTZ@203682|Planctomycetes	203682|Planctomycetes	N	GTP-binding signal recognition particle SRP54	flhF	-	-	ko:K02404	-	-	-	-	ko00000,ko02035	-	-	-	SRP54
TH2_k127_3401855_0	289376.THEYE_A2075	4.678e-222	708.0	COG1298@1|root,COG1298@2|Bacteria,3J0B1@40117|Nitrospirae	40117|Nitrospirae	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
TH2_k127_3401855_3	289376.THEYE_A2076	5.534e-72	255.0	COG1377@1|root,COG1377@2|Bacteria,3J0J3@40117|Nitrospirae	40117|Nitrospirae	N	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhB	-	-	ko:K02401	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_2
TH2_k127_3401855_8	228410.NE0459	3.676e-33	138.0	COG1684@1|root,COG1684@2|Bacteria,1NIF4@1224|Proteobacteria,2VQ64@28216|Betaproteobacteria,37217@32003|Nitrosomonadales	28216|Betaproteobacteria	N	Role in flagellar biosynthesis	fliR	-	-	ko:K02421	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1
TH2_k127_3401855_10	314345.SPV1_07726	1.14e-16	90.0	COG1987@1|root,COG1987@2|Bacteria,1N73W@1224|Proteobacteria	1224|Proteobacteria	N	Flagellar biosynthetic protein FliQ	fliQ	-	-	ko:K02420	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_3
TH2_k127_3401855_2	56780.SYN_02835	1.468e-72	251.0	COG1338@1|root,COG1338@2|Bacteria,1MVBU@1224|Proteobacteria,42NDZ@68525|delta/epsilon subdivisions,2WKCN@28221|Deltaproteobacteria,2MRNK@213462|Syntrophobacterales	28221|Deltaproteobacteria	N	FliP family	fliP	-	-	ko:K02419	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliP
TH2_k127_3401855_7	941449.dsx2_1956	2.585e-37	143.0	COG1886@1|root,COG1886@2|Bacteria,1RGWT@1224|Proteobacteria,42TQB@68525|delta/epsilon subdivisions,2WQCQ@28221|Deltaproteobacteria,2MB3C@213115|Desulfovibrionales	28221|Deltaproteobacteria	N	PFAM surface presentation of antigens (SPOA) protein	fliN	-	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FliMN_C
TH2_k127_3401855_4	644282.Deba_2312	2.057e-71	255.0	COG1868@1|root,COG1868@2|Bacteria,1MX01@1224|Proteobacteria,42N2Y@68525|delta/epsilon subdivisions,2WIS2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	N	flagellar motor switch protein FliM	fliM	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
TH2_k127_3401855_9	525897.Dbac_2735	3.761e-21	99.0	COG1580@1|root,COG1580@2|Bacteria,1NBUX@1224|Proteobacteria,42RSV@68525|delta/epsilon subdivisions,2WR7K@28221|Deltaproteobacteria,2MBZ2@213115|Desulfovibrionales	28221|Deltaproteobacteria	N	Controls the rotational direction of flagella during chemotaxis	fliL	-	-	ko:K02415	-	-	-	-	ko00000,ko02035	-	-	-	FliL
TH2_k127_3401855_11	13616.ENSMODP00000013176	0.0004362	43.0	COG0666@1|root,KOG0504@2759|Eukaryota,39S8I@33154|Opisthokonta,3BKQB@33208|Metazoa,3D0U5@33213|Bilateria,485C5@7711|Chordata,49692@7742|Vertebrata,3JC0F@40674|Mammalia,4K327@9263|Metatheria	33208|Metazoa	S	Fibronectin type III and ankyrin repeat domains 1	FANK1	GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005929,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010941,GO:0010942,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031974,GO:0031981,GO:0042981,GO:0042995,GO:0043065,GO:0043066,GO:0043067,GO:0043068,GO:0043069,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044093,GO:0044422,GO:0044424,GO:0044428,GO:0044441,GO:0044444,GO:0044446,GO:0044463,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051090,GO:0051091,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0060548,GO:0065007,GO:0065009,GO:0070013,GO:0080090,GO:0097546,GO:0120025,GO:0120038,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_4,Ank_5
TH2_k127_3407916_3	56780.SYN_01009	6.225e-112	369.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2MR2C@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
TH2_k127_3407916_4	1167006.UWK_03057	2.333e-71	244.0	COG0041@1|root,COG0041@2|Bacteria	2|Bacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18,6.3.4.13	ko:K01588,ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R07405	RC00090,RC00166,RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
TH2_k127_3407916_7	255470.cbdbA1606	8.595e-40	152.0	COG2862@1|root,COG2862@2|Bacteria,2G9EC@200795|Chloroflexi,34DEF@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Uncharacterized protein family, UPF0114	-	-	-	-	-	-	-	-	-	-	-	-	UPF0114
TH2_k127_3407916_1	289376.THEYE_A0960	3.503e-126	410.0	COG0501@1|root,COG0501@2|Bacteria,3J0QG@40117|Nitrospirae	40117|Nitrospirae	O	Peptidase family M48	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
TH2_k127_3407916_0	289376.THEYE_A1461	1.121e-318	1004.0	COG0178@1|root,COG0178@2|Bacteria,3J0ZV@40117|Nitrospirae	40117|Nitrospirae	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	-
TH2_k127_3407916_5	289376.THEYE_A0351	5.13e-66	239.0	COG1663@1|root,COG1663@2|Bacteria,3J0QN@40117|Nitrospirae	40117|Nitrospirae	M	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
TH2_k127_3407916_6	316067.Geob_2945	1.316e-41	163.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,42TZY@68525|delta/epsilon subdivisions,2WRWF@28221|Deltaproteobacteria,43UKD@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Bacterial regulatory proteins, crp family	fnr-2	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
TH2_k127_3407916_2	909663.KI867150_gene86	2.351e-115	374.0	28KNW@1|root,2ZA74@2|Bacteria,1RCXY@1224|Proteobacteria,42S71@68525|delta/epsilon subdivisions,2WNUZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Restriction endonuclease XhoI	-	-	-	-	-	-	-	-	-	-	-	-	XhoI
TH2_k127_3412083_8	289376.THEYE_A0673	5.041e-11	63.0	COG0302@1|root,COG0302@2|Bacteria,3J0Q0@40117|Nitrospirae	40117|Nitrospirae	F	GTP cyclohydrolase I	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
TH2_k127_3412083_5	266117.Rxyl_1321	2.507e-39	153.0	COG0212@1|root,COG0212@2|Bacteria	2|Bacteria	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	ygfA	GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0022611,GO:0030272,GO:0032502,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	iECABU_c1320.ECABU_c31940,iECOK1_1307.ECOK1_3298,iECSF_1327.ECSF_2705,iUTI89_1310.UTI89_C3298	5-FTHF_cyc-lig
TH2_k127_3412083_3	2325.TKV_c20090	4.95e-94	316.0	COG3640@1|root,COG3640@2|Bacteria,1TPCY@1239|Firmicutes,247JM@186801|Clostridia,42F6P@68295|Thermoanaerobacterales	186801|Clostridia	D	CO dehydrogenase	cooC	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
TH2_k127_3412083_2	247490.KSU1_B0394	2.273e-99	333.0	COG0685@1|root,COG0685@2|Bacteria,2J1PK@203682|Planctomycetes	203682|Planctomycetes	C	Methylenetetrahydrofolate reductase	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
TH2_k127_3412083_4	96561.Dole_1152	7.38e-85	286.0	COG4656@1|root,COG4656@2|Bacteria,1MWAX@1224|Proteobacteria,42NJM@68525|delta/epsilon subdivisions,2WJJB@28221|Deltaproteobacteria,2MHNS@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Methylene-tetrahydrofolate reductase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	MTHFR_C
TH2_k127_3412083_7	880072.Desac_0036	1.488e-21	95.0	COG1908@1|root,COG1908@2|Bacteria,1MZ7V@1224|Proteobacteria,42UHS@68525|delta/epsilon subdivisions,2WQMX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	FlpD
TH2_k127_3412083_6	96561.Dole_1158	2.402e-34	133.0	COG1908@1|root,COG1908@2|Bacteria,1RCZY@1224|Proteobacteria,42T3M@68525|delta/epsilon subdivisions,2WPVI@28221|Deltaproteobacteria,2MKVM@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	FlpD
TH2_k127_3412083_0	1121405.dsmv_2897	0.0	1528.0	COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIJ3@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Pyr_redox_2
TH2_k127_3412083_1	1121405.dsmv_2896	1.805e-116	383.0	COG2048@1|root,COG2048@2|Bacteria,1N37J@1224|Proteobacteria,42P51@68525|delta/epsilon subdivisions,2WK1J@28221|Deltaproteobacteria,2MKTG@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Cysteine-rich domain	hdrB	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
TH2_k127_3412083_9	1121405.dsmv_2895	2.742e-07	54.0	COG1150@1|root,COG1150@2|Bacteria,1RHH3@1224|Proteobacteria,42SBS@68525|delta/epsilon subdivisions,2WPKY@28221|Deltaproteobacteria,2MKW7@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390,ko:K16887	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_17,Fer4_9
TH2_k127_3458712_13	742738.HMPREF9460_03360	5.466e-06	49.0	COG1040@1|root,COG1040@2|Bacteria,1VF2G@1239|Firmicutes,24IG6@186801|Clostridia,267PX@186813|unclassified Clostridiales	186801|Clostridia	S	Phosphoribosyl transferase domain	comF	-	-	ko:K02242	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	Pribosyltran
TH2_k127_3458712_1	1123376.AUIU01000015_gene432	6.686e-245	769.0	COG0744@1|root,COG0744@2|Bacteria,3J1FP@40117|Nitrospirae	40117|Nitrospirae	M	Transglycosylase	-	-	2.4.1.129,3.4.16.4	ko:K05365,ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
TH2_k127_3458712_12	323848.Nmul_A0021	2.017e-08	64.0	2EBKH@1|root,335KX@2|Bacteria,1NAWH@1224|Proteobacteria,2W4UC@28216|Betaproteobacteria,373GK@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3458712_8	1125863.JAFN01000001_gene2683	3.613e-93	313.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,42MTF@68525|delta/epsilon subdivisions,2WJ6X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	PFAM Cobyrinic acid ac-diamide synthase	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
TH2_k127_3458712_7	1123376.AUIU01000015_gene430	2.524e-99	332.0	COG1475@1|root,COG1475@2|Bacteria,3J0K9@40117|Nitrospirae	40117|Nitrospirae	K	ParB-like nuclease domain	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
TH2_k127_3458712_10	589865.DaAHT2_0538	3.776e-39	160.0	COG2755@1|root,COG2755@2|Bacteria,1NIYF@1224|Proteobacteria,42XYT@68525|delta/epsilon subdivisions,2WTHB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
TH2_k127_3458712_2	289377.HL41_00285	1.366e-242	760.0	COG0504@1|root,COG0504@2|Bacteria,2GHMU@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
TH2_k127_3458712_9	404380.Gbem_1599	5.72e-72	251.0	COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,42PTX@68525|delta/epsilon subdivisions,2WMQW@28221|Deltaproteobacteria,43T2I@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
TH2_k127_3458712_4	1123376.AUIU01000013_gene1724	6.402e-160	521.0	COG0815@1|root,COG0815@2|Bacteria,3J0HA@40117|Nitrospirae	40117|Nitrospirae	M	Carbon-nitrogen hydrolase	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
TH2_k127_3458712_5	648996.Theam_0242	1.06e-120	397.0	COG1186@1|root,COG1186@2|Bacteria,2G3P3@200783|Aquificae	200783|Aquificae	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
TH2_k127_3458712_3	289376.THEYE_A0015	4.954e-177	565.0	COG0593@1|root,COG0593@2|Bacteria,3J0FQ@40117|Nitrospirae	40117|Nitrospirae	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
TH2_k127_3458712_6	289376.THEYE_A0016	4.01e-108	361.0	COG0592@1|root,COG0592@2|Bacteria,3J0RU@40117|Nitrospirae	40117|Nitrospirae	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
TH2_k127_3458712_0	289376.THEYE_A0017	2.615e-268	844.0	COG0187@1|root,COG0187@2|Bacteria,3J0BB@40117|Nitrospirae	40117|Nitrospirae	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
TH2_k127_349808_4	290397.Adeh_1998	8.096e-15	83.0	COG4585@1|root,COG4585@2|Bacteria,1N0JE@1224|Proteobacteria,42UG3@68525|delta/epsilon subdivisions,2WQFT@28221|Deltaproteobacteria,2Z1DF@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA_3
TH2_k127_349808_2	404589.Anae109_1806	2.314e-49	188.0	COG2864@1|root,COG2864@2|Bacteria,1NJEJ@1224|Proteobacteria,42NQM@68525|delta/epsilon subdivisions,2WK76@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
TH2_k127_349808_1	404589.Anae109_1805	8.546e-73	264.0	COG3005@1|root,COG3005@2|Bacteria,1QYG3@1224|Proteobacteria,43CC8@68525|delta/epsilon subdivisions,2X7N4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c3	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
TH2_k127_349808_0	1379698.RBG1_1C00001G0773	1.916e-109	369.0	COG5557@1|root,COG5557@2|Bacteria,2NQYU@2323|unclassified Bacteria	2|Bacteria	C	Polysulphide reductase, NrfD	hmcC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	NrfD
TH2_k127_349808_3	1167006.UWK_03038	2.872e-46	171.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42M97@68525|delta/epsilon subdivisions,2WJB4@28221|Deltaproteobacteria,2MJB7@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	hmcB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Fer4_11,Fer4_4,Fer4_7
TH2_k127_3506013_1	289376.THEYE_A0784	2.582e-205	650.0	COG4231@1|root,COG4231@2|Bacteria	2|Bacteria	C	indolepyruvate ferredoxin oxidoreductase activity	iorA	-	1.2.7.8	ko:K00179,ko:K08941	-	M00598	-	-	br01601,ko00000,ko00002,ko00194,ko01000	-	-	-	POR_N,TPP_enzyme_C
TH2_k127_3506013_8	868131.MSWAN_1227	1.527e-58	207.0	COG4747@1|root,arCOG04444@2157|Archaea,2XZI5@28890|Euryarchaeota,23P65@183925|Methanobacteria	183925|Methanobacteria	S	amino acid-binding ACT	-	-	-	-	-	-	-	-	-	-	-	-	ACT
TH2_k127_3506013_0	289376.THEYE_A0782	7.992e-215	674.0	COG1541@1|root,COG1541@2|Bacteria	2|Bacteria	H	phenylacetate-CoA ligase activity	paaK	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
TH2_k127_3506013_9	289376.THEYE_A0781	7.852e-39	150.0	COG4747@1|root,COG4747@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ACT
TH2_k127_3506013_2	289376.THEYE_A0780	4.107e-202	636.0	COG1541@1|root,COG1541@2|Bacteria	2|Bacteria	H	phenylacetate-CoA ligase activity	paaK	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
TH2_k127_3506013_6	1123376.AUIU01000001_gene762	1.057e-59	214.0	COG1014@1|root,COG1014@2|Bacteria	2|Bacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
TH2_k127_3506013_3	404589.Anae109_1759	6.386e-195	621.0	COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,42N9T@68525|delta/epsilon subdivisions,2WIMI@28221|Deltaproteobacteria,2Z24K@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
TH2_k127_3506013_7	243231.GSU1736	8.402e-59	206.0	COG4747@1|root,COG4747@2|Bacteria,1RDCG@1224|Proteobacteria,42RTD@68525|delta/epsilon subdivisions,2WNC2@28221|Deltaproteobacteria,43SGJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	PFAM amino acid-binding ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ACT
TH2_k127_3506013_4	1167006.UWK_00092	4.037e-146	473.0	COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,42MXX@68525|delta/epsilon subdivisions,2WKJM@28221|Deltaproteobacteria,2MHQS@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TH2_k127_3506013_5	1121403.AUCV01000039_gene4376	2.043e-65	228.0	COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,42MXX@68525|delta/epsilon subdivisions,2WKJM@28221|Deltaproteobacteria,2MHQS@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TH2_k127_3585199_5	1123376.AUIU01000018_gene16	3.184e-38	152.0	COG3271@1|root,COG3271@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C39,Peptidase_C39_2,TPR_16
TH2_k127_3585199_8	1307759.JOMJ01000003_gene1876	2.663e-22	101.0	2E20Q@1|root,32X8P@2|Bacteria,1N3P4@1224|Proteobacteria,42TSV@68525|delta/epsilon subdivisions,2WQ7Q@28221|Deltaproteobacteria,2MCZ9@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3585199_10	204536.SULAZ_0562	6.224e-14	78.0	2E20Q@1|root,32X8P@2|Bacteria,2G53C@200783|Aquificae	200783|Aquificae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3585199_2	289376.THEYE_A0341	1.679e-95	326.0	COG0787@1|root,COG0787@2|Bacteria,3J0JH@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
TH2_k127_3585199_9	1123376.AUIU01000011_gene1046	2.101e-20	93.0	COG1826@1|root,COG1826@2|Bacteria,3J1A4@40117|Nitrospirae	40117|Nitrospirae	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
TH2_k127_3585199_6	477974.Daud_0985	3.706e-31	130.0	COG0746@1|root,COG1763@1|root,COG0746@2|Bacteria,COG1763@2|Bacteria,1VA6T@1239|Firmicutes,24JG6@186801|Clostridia,262DJ@186807|Peptococcaceae	186801|Clostridia	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752,ko:K13818	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
TH2_k127_3585199_3	1123376.AUIU01000011_gene1048	1.624e-77	270.0	COG1355@1|root,COG1355@2|Bacteria,3J0U4@40117|Nitrospirae	40117|Nitrospirae	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
TH2_k127_3585199_0	289376.THEYE_A0337	6.433e-195	618.0	COG0305@1|root,COG0305@2|Bacteria,3J0EZ@40117|Nitrospirae	40117|Nitrospirae	L	Participates in initiation and elongation during chromosome replication	-	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
TH2_k127_3585199_4	290397.Adeh_0116	8.387e-45	167.0	COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,42SCQ@68525|delta/epsilon subdivisions,2WPZQ@28221|Deltaproteobacteria,2YX0Q@29|Myxococcales	28221|Deltaproteobacteria	J	binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
TH2_k127_3585199_7	342113.DM82_4859	1.136e-23	104.0	COG2963@1|root,COG2963@2|Bacteria,1NDI2@1224|Proteobacteria,2WEUS@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM transposase IS3 IS911 family protein	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
TH2_k127_3585199_1	552811.Dehly_0447	5.434e-118	385.0	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,2G8GQ@200795|Chloroflexi,34DDP@301297|Dehalococcoidia	301297|Dehalococcoidia	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
TH2_k127_358622_15	671143.DAMO_2938	2.326e-19	90.0	COG1274@1|root,COG1274@2|Bacteria,2NQRD@2323|unclassified Bacteria	2|Bacteria	C	Phosphoenolpyruvate carboxykinase C-terminal P-loop domain	pckG	-	4.1.1.32,4.1.1.49	ko:K01596,ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003,M00170	R00341,R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP,PEPCK_C,PEPCK_N
TH2_k127_358622_1	289376.THEYE_A1817	7.657e-151	490.0	COG0141@1|root,COG0141@2|Bacteria,3J0C6@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
TH2_k127_358622_16	243231.GSU0481	3.118e-19	89.0	2ER59@1|root,33IQV@2|Bacteria,1NMF6@1224|Proteobacteria,42Y36@68525|delta/epsilon subdivisions,2WT0Q@28221|Deltaproteobacteria,43VTT@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_358622_9	243231.GSU0480	8.053e-31	122.0	COG0694@1|root,COG0694@2|Bacteria,1MVQ1@1224|Proteobacteria,42V85@68525|delta/epsilon subdivisions,2WR93@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PFAM nitrogen-fixing NifU domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Nfu_N,NifU
TH2_k127_358622_5	289376.THEYE_A0979	1.134e-53	191.0	COG0780@1|root,COG0780@2|Bacteria,3J0R4@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
TH2_k127_358622_13	316067.Geob_2256	5.337e-26	117.0	2BAVZ@1|root,324BI@2|Bacteria,1RJN7@1224|Proteobacteria,430EY@68525|delta/epsilon subdivisions,2WVNN@28221|Deltaproteobacteria,43VA5@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Cytochrome P460	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_P460
TH2_k127_358622_4	243231.GSU2378	3.894e-63	224.0	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,42QQ3@68525|delta/epsilon subdivisions,2WNPH@28221|Deltaproteobacteria,43U0C@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
TH2_k127_358622_0	909663.KI867150_gene1612	4.736e-246	767.0	COG1350@1|root,COG1350@2|Bacteria,1N07Y@1224|Proteobacteria,42MPB@68525|delta/epsilon subdivisions,2WJUV@28221|Deltaproteobacteria,2MQZ7@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB2	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TH2_k127_358622_2	909663.KI867150_gene2238	1.272e-130	442.0	COG3266@1|root,COG3266@2|Bacteria,1QYJ8@1224|Proteobacteria	1224|Proteobacteria	D	nuclear chromosome segregation	fimV_2	-	-	-	-	-	-	-	-	-	-	-	FecR
TH2_k127_358622_7	760568.Desku_0316	4.395e-38	148.0	COG0394@1|root,COG0394@2|Bacteria,1V3JW@1239|Firmicutes,24HBX@186801|Clostridia,26390@186807|Peptococcaceae	186801|Clostridia	T	Catalyzes the reduction of arsenate As(V) to arsenite As(III)	arsC	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
TH2_k127_358622_10	1265505.ATUG01000001_gene3875	1.618e-29	124.0	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,42U6P@68525|delta/epsilon subdivisions,2WQ00@28221|Deltaproteobacteria,2MKG2@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM HNH endonuclease	-	-	-	ko:K07451	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HNH_5
TH2_k127_358622_12	1123376.AUIU01000011_gene1029	2.844e-26	110.0	COG2952@1|root,COG2952@2|Bacteria,3J1ED@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF507)	-	-	-	-	-	-	-	-	-	-	-	-	DUF507
TH2_k127_358622_11	289376.THEYE_A0795	1.282e-26	110.0	COG0238@1|root,COG0238@2|Bacteria,3J1F7@40117|Nitrospirae	40117|Nitrospirae	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
TH2_k127_358622_6	289376.THEYE_A0794	1.014e-45	169.0	COG0629@1|root,COG0629@2|Bacteria,3J0NB@40117|Nitrospirae	40117|Nitrospirae	L	Single-strand binding protein family	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
TH2_k127_358622_8	289376.THEYE_A0793	3.083e-35	139.0	COG0360@1|root,COG0360@2|Bacteria,3J0VS@40117|Nitrospirae	40117|Nitrospirae	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
TH2_k127_358622_3	338963.Pcar_1994	1.807e-125	417.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,43RYA@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	gnfM	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH2_k127_3680130_2	237368.SCABRO_02094	6.724e-122	396.0	COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria	2|Bacteria	L	Protein of unknown function (DUF1722)	ybgA	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
TH2_k127_3680130_6	1280666.ATVS01000006_gene2205	3.114e-23	108.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V1DC@1239|Firmicutes,24GJV@186801|Clostridia,4BY6K@830|Butyrivibrio	186801|Clostridia	T	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,HTH_AraC,Response_reg
TH2_k127_3680130_5	926561.KB900617_gene2032	9.467e-26	117.0	COG0697@1|root,COG0697@2|Bacteria,1UAMA@1239|Firmicutes,24B3H@186801|Clostridia,3WC7A@53433|Halanaerobiales	186801|Clostridia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TH2_k127_3680130_1	1220534.B655_1300	3.254e-169	541.0	COG1488@1|root,arCOG01481@2157|Archaea,2XU8Y@28890|Euryarchaeota	28890|Euryarchaeota	H	Nicotinic acid phosphoribosyltransferase	pncB	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	QRPTase_C,QRPTase_N
TH2_k127_3680130_3	289376.THEYE_A1534	5.299e-90	308.0	COG2206@1|root,COG2206@2|Bacteria,3J14V@40117|Nitrospirae	40117|Nitrospirae	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD
TH2_k127_3680130_0	289376.THEYE_A1533	4.269e-182	579.0	COG2256@1|root,COG2256@2|Bacteria,3J0H6@40117|Nitrospirae	40117|Nitrospirae	L	MgsA AAA+ ATPase C terminal	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA_assoc_2,MgsA_C,RuvB_N
TH2_k127_3680130_4	858215.Thexy_1683	2.416e-33	135.0	COG1247@1|root,COG1247@2|Bacteria,1UHYR@1239|Firmicutes,24H0A@186801|Clostridia,42G6C@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TH2_k127_3680130_7	289376.THEYE_A0547	4.937e-23	101.0	COG0585@1|root,COG0585@2|Bacteria	2|Bacteria	J	pseudouridine synthase activity	truD	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
TH2_k127_3741196_12	997346.HMPREF9374_3459	0.0002645	47.0	COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,4HB7D@91061|Bacilli,27BIZ@186824|Thermoactinomycetaceae	91061|Bacilli	O	Subtilase family	-	-	3.4.21.66	ko:K08651	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	PPC,Peptidase_S8
TH2_k127_3741196_1	316067.Geob_0895	6.531e-190	606.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	PFAM Type II secretion system protein E	gspE	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
TH2_k127_3741196_4	1255043.TVNIR_3841	1.436e-54	207.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,1WXA3@135613|Chromatiales	135613|Chromatiales	U	General secretion pathway protein F	-	-	-	ko:K02455	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSF
TH2_k127_3741196_3	443143.GM18_3762	3.252e-56	200.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,42SFB@68525|delta/epsilon subdivisions,2WP3B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	general secretion pathway protein G	gspG	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
TH2_k127_3741196_11	697282.Mettu_1873	2.192e-05	53.0	COG4970@1|root,COG4970@2|Bacteria,1NBWI@1224|Proteobacteria,1S5MN@1236|Gammaproteobacteria,1XF9I@135618|Methylococcales	135618|Methylococcales	U	General secretion pathway protein H	-	-	-	ko:K02457	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GspH,N_methyl
TH2_k127_3741196_8	269799.Gmet_3369	8.01e-08	61.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	gspI	GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705	-	ko:K02456,ko:K02457,ko:K02458,ko:K02459	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSI
TH2_k127_3741196_6	243231.GSU0323	1.358e-24	113.0	COG4795@1|root,COG4795@2|Bacteria	2|Bacteria	U	General secretion pathway protein	gspJ	GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0098776	-	ko:K02459	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSJ
TH2_k127_3741196_5	243231.GSU0322	2.094e-28	128.0	COG3156@1|root,COG3156@2|Bacteria,1N9I4@1224|Proteobacteria,42V0N@68525|delta/epsilon subdivisions,2WRR8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	PFAM General secretion pathway protein K	gspK	-	-	ko:K02460	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSK
TH2_k127_3741196_10	316067.Geob_0888	3.794e-07	62.0	COG3297@1|root,COG3297@2|Bacteria	2|Bacteria	U	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins	gspL	-	-	ko:K02461	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GspL_C,T2SSL
TH2_k127_3741196_9	1232410.KI421418_gene2149	1.274e-07	62.0	COG3149@1|root,COG3149@2|Bacteria,1Q1NE@1224|Proteobacteria,43EXY@68525|delta/epsilon subdivisions,2X2IW@28221|Deltaproteobacteria,43VM5@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3741196_7	243231.GSU0319	6.032e-12	76.0	2DRH1@1|root,33BQ8@2|Bacteria	2|Bacteria	-	-	gspN	-	-	-	-	-	-	-	-	-	-	-	AsmA_2
TH2_k127_3741196_0	269799.Gmet_0138	4.73e-197	625.0	COG5316@1|root,COG5316@2|Bacteria,1QCVP@1224|Proteobacteria,42QA4@68525|delta/epsilon subdivisions,2WKD1@28221|Deltaproteobacteria,43SDE@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139,DUF4140
TH2_k127_3741196_2	443143.GM18_0500	7.548e-63	226.0	COG0681@1|root,COG0681@2|Bacteria,1RKJ5@1224|Proteobacteria,431MY@68525|delta/epsilon subdivisions,2WX07@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	TIGRFAM signal peptidase I	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
TH2_k127_3778300_3	1167006.UWK_01998	7.086e-19	99.0	COG0438@1|root,COG0438@2|Bacteria,1NB81@1224|Proteobacteria,42QJ7@68525|delta/epsilon subdivisions,2WPQE@28221|Deltaproteobacteria,2MKG7@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TH2_k127_3778300_1	65393.PCC7424_5865	3.825e-49	199.0	COG1216@1|root,COG1216@2|Bacteria,1GIT7@1117|Cyanobacteria,3KK6J@43988|Cyanothece	1117|Cyanobacteria	S	PFAM glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TH2_k127_3778300_0	1380347.JNII01000007_gene412	6.246e-64	241.0	COG0438@1|root,COG0463@1|root,COG0500@1|root,COG0438@2|Bacteria,COG0463@2|Bacteria,COG2226@2|Bacteria,2ICWD@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TH2_k127_3778300_2	1380347.JNII01000007_gene412	2.042e-23	104.0	COG0438@1|root,COG0463@1|root,COG0500@1|root,COG0438@2|Bacteria,COG0463@2|Bacteria,COG2226@2|Bacteria,2ICWD@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TH2_k127_3799751_2	243231.GSU2916	4.545e-72	261.0	COG4191@1|root,COG4191@2|Bacteria,1R5Q1@1224|Proteobacteria,42TFH@68525|delta/epsilon subdivisions,2WPEH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase HAMP	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TH2_k127_3799751_1	517418.Ctha_2235	3.684e-89	329.0	COG0784@1|root,COG3829@1|root,COG4191@1|root,COG4936@1|root,COG0784@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,COG4936@2|Bacteria	2|Bacteria	KT	Sensory domain found in PocR	nifL	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,PocR,Response_reg
TH2_k127_3799751_0	247490.KSU1_C1305	7.271e-315	975.0	COG0296@1|root,COG0296@2|Bacteria,2IXS1@203682|Planctomycetes	203682|Planctomycetes	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
TH2_k127_3799751_3	880072.Desac_1098	1.486e-36	153.0	COG0859@1|root,COG0859@2|Bacteria,1NABN@1224|Proteobacteria,42V15@68525|delta/epsilon subdivisions,2WRJN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM glycosyl transferase family 9	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
TH2_k127_3805695_4	756272.Plabr_3705	7.048e-68	256.0	COG0457@1|root,COG0793@1|root,COG4995@1|root,COG0457@2|Bacteria,COG0793@2|Bacteria,COG4995@2|Bacteria,2J07X@203682|Planctomycetes	203682|Planctomycetes	M	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_10,TPR_12,TPR_7,TPR_8
TH2_k127_3805695_7	247490.KSU1_C1141	2.557e-18	87.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_5,Phage_integrase
TH2_k127_3805695_6	667014.Thein_2172	4.23e-54	194.0	COG1327@1|root,COG1327@2|Bacteria,2GGU9@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
TH2_k127_3805695_0	289376.THEYE_A1387	3.452e-193	610.0	COG0112@1|root,COG0112@2|Bacteria,3J0CB@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
TH2_k127_3805695_5	289376.THEYE_A1386	7.993e-55	195.0	COG0698@1|root,COG0698@2|Bacteria,3J14S@40117|Nitrospirae	40117|Nitrospirae	G	Ribose/Galactose Isomerase	-	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
TH2_k127_3805695_2	289376.THEYE_A0670	2.052e-109	372.0	COG0078@1|root,COG0078@2|Bacteria,3J0G7@40117|Nitrospirae	40117|Nitrospirae	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
TH2_k127_3805695_1	289376.THEYE_A0671	5.97e-166	531.0	COG4992@1|root,COG4992@2|Bacteria,3J0AB@40117|Nitrospirae	40117|Nitrospirae	E	Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TH2_k127_3805695_3	1121405.dsmv_2895	3.278e-70	244.0	COG1150@1|root,COG1150@2|Bacteria,1RHH3@1224|Proteobacteria,42SBS@68525|delta/epsilon subdivisions,2WPKY@28221|Deltaproteobacteria,2MKW7@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390,ko:K16887	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_17,Fer4_9
TH2_k127_3817160_1	706587.Desti_3940	1.618e-261	821.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,43BQE@68525|delta/epsilon subdivisions,2X71H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	carboxylase	-	-	6.4.1.3,6.4.1.4	ko:K01965,ko:K01968	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00036,M00373,M00741	R01859,R04138	RC00097,RC00367,RC00609,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
TH2_k127_3817160_27	1437824.BN940_06176	1.513e-09	64.0	2E3UE@1|root,32YRS@2|Bacteria,1N75A@1224|Proteobacteria,2VY2D@28216|Betaproteobacteria,3T7QF@506|Alcaligenaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF2799)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2799
TH2_k127_3817160_28	1123228.AUIH01000001_gene1405	5.518e-09	64.0	2E3UE@1|root,32YRS@2|Bacteria,1N75A@1224|Proteobacteria,1S9W5@1236|Gammaproteobacteria,1XM11@135619|Oceanospirillales	135619|Oceanospirillales	S	Protein of unknown function (DUF2799)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2799
TH2_k127_3817160_20	289376.THEYE_A1679	5.92e-34	132.0	COG1977@1|root,COG1977@2|Bacteria,3J0T2@40117|Nitrospirae	40117|Nitrospirae	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
TH2_k127_3817160_24	289376.THEYE_A1680	1.201e-27	114.0	COG1135@1|root,COG1135@2|Bacteria,3J0VT@40117|Nitrospirae	40117|Nitrospirae	P	NIL	-	-	-	-	-	-	-	-	-	-	-	-	NIL
TH2_k127_3817160_7	289376.THEYE_A1682	8.978e-157	504.0	COG3635@1|root,COG3635@2|Bacteria,3J0YA@40117|Nitrospirae	40117|Nitrospirae	G	Metalloenzyme superfamily	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
TH2_k127_3817160_6	944481.JAFP01000001_gene50	2.412e-158	508.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,42NDT@68525|delta/epsilon subdivisions,2WIWZ@28221|Deltaproteobacteria,2M6AW@213113|Desulfurellales	28221|Deltaproteobacteria	E	ACT domain	lysC	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
TH2_k127_3817160_2	289376.THEYE_A0785	2.134e-252	786.0	COG0119@1|root,COG0119@2|Bacteria,3J0DC@40117|Nitrospirae	40117|Nitrospirae	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
TH2_k127_3817160_25	1121405.dsmv_2922	1.8e-13	78.0	COG3086@1|root,COG3086@2|Bacteria,1PKXC@1224|Proteobacteria,42UU9@68525|delta/epsilon subdivisions,2WPMZ@28221|Deltaproteobacteria,2MK8X@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM Positive regulator of sigma(E) RseC MucC	-	-	-	ko:K03803	-	-	-	-	ko00000,ko03021	-	-	-	RseC_MucC
TH2_k127_3817160_0	289376.THEYE_A0554	2.209e-313	973.0	COG0480@1|root,COG0480@2|Bacteria,3J0WU@40117|Nitrospirae	40117|Nitrospirae	J	Elongation factor G, domain IV	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
TH2_k127_3817160_5	338963.Pcar_2418	4.5e-184	587.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,42M7Y@68525|delta/epsilon subdivisions,2WIRN@28221|Deltaproteobacteria,43RY2@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Argininosuccinate lyase C-terminal	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1,NUDIX
TH2_k127_3817160_10	289376.THEYE_A0551	4.146e-129	420.0	COG0309@1|root,COG0309@2|Bacteria,3J0ZN@40117|Nitrospirae	40117|Nitrospirae	O	AIR synthase related protein, N-terminal domain	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
TH2_k127_3817160_15	289376.THEYE_A0550	9.105e-69	245.0	COG0760@1|root,COG0760@2|Bacteria,3J0SR@40117|Nitrospirae	40117|Nitrospirae	O	SurA N-terminal domain	-	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3,SurA_N
TH2_k127_3817160_13	289376.THEYE_A0549	2.451e-87	295.0	COG1187@1|root,COG1187@2|Bacteria,3J0RN@40117|Nitrospirae	40117|Nitrospirae	J	Belongs to the pseudouridine synthase RsuA family	-	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TH2_k127_3817160_3	289376.THEYE_A0617	4.696e-246	772.0	COG0173@1|root,COG0173@2|Bacteria,3J0FR@40117|Nitrospirae	40117|Nitrospirae	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
TH2_k127_3817160_14	289376.THEYE_A0395	1.969e-73	263.0	COG2770@1|root,COG2770@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,HATPase_c,HisKA
TH2_k127_3817160_16	1123376.AUIU01000013_gene1768	1.545e-48	191.0	COG0745@1|root,COG0745@2|Bacteria	1123376.AUIU01000013_gene1768|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3817160_18	1123376.AUIU01000013_gene1769	4.429e-37	145.0	COG0745@1|root,COG0745@2|Bacteria,3J16K@40117|Nitrospirae	40117|Nitrospirae	T	cheY-homologous receiver domain	-	-	-	ko:K02658	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
TH2_k127_3817160_17	1123376.AUIU01000013_gene1770	8.321e-40	152.0	COG0835@1|root,COG0835@2|Bacteria	2|Bacteria	NT	chemotaxis	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
TH2_k127_3817160_8	1121918.ARWE01000001_gene1431	2.462e-154	515.0	COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	Signal transducing histidine kinase homodimeric	frzE	-	2.7.13.3	ko:K03407,ko:K13490	ko02020,ko02025,ko02030,map02020,map02025,map02030	M00506,M00509	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
TH2_k127_3817160_9	289376.THEYE_A0390	1.696e-142	466.0	COG0840@1|root,COG2972@1|root,COG0840@2|Bacteria,COG2972@2|Bacteria,3J11V@40117|Nitrospirae	40117|Nitrospirae	T	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	ko:K02660	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	HAMP,MCPsignal
TH2_k127_3817160_4	1123376.AUIU01000011_gene1119	3.875e-203	647.0	COG2804@1|root,COG2804@2|Bacteria,3J0XR@40117|Nitrospirae	40117|Nitrospirae	NU	Type II/IV secretion system protein	-	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
TH2_k127_3817160_12	1499967.BAYZ01000068_gene1962	2.602e-91	312.0	COG4972@1|root,COG4972@2|Bacteria,2NPF6@2323|unclassified Bacteria	2|Bacteria	NU	Type IV pilus assembly protein PilM;	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
TH2_k127_3817160_23	289376.THEYE_A0421	9.187e-30	126.0	COG3166@1|root,COG3166@2|Bacteria,3J1EX@40117|Nitrospirae	40117|Nitrospirae	NU	Fimbrial assembly protein (PilN)	-	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
TH2_k127_3817160_19	289376.THEYE_A0420	9.544e-35	141.0	COG3167@1|root,COG3167@2|Bacteria,3J1BH@40117|Nitrospirae	40117|Nitrospirae	NU	Pilus assembly protein, PilO	-	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
TH2_k127_3817160_26	1499967.BAYZ01000068_gene1959	2.828e-10	68.0	COG3168@1|root,COG3168@2|Bacteria	2|Bacteria	NU	Pilus assembly protein, PilP	pilP	-	-	ko:K02664,ko:K02665	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilP
TH2_k127_3817160_11	1123376.AUIU01000001_gene754	9.437e-116	402.0	COG4796@1|root,COG4796@2|Bacteria,3J0Q9@40117|Nitrospirae	40117|Nitrospirae	U	Secretin and TonB N terminus short domain	-	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	Secretin,Secretin_N
TH2_k127_3952258_3	909663.KI867150_gene448	6.892e-61	216.0	COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,42RVP@68525|delta/epsilon subdivisions,2WNCX@28221|Deltaproteobacteria,2MQI0@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Appr-1'-p processing enzyme	ymdB	-	-	-	-	-	-	-	-	-	-	-	Macro
TH2_k127_3952258_1	871963.Desdi_2304	6.284e-98	333.0	COG1641@1|root,COG1641@2|Bacteria,1TPAV@1239|Firmicutes,247ZH@186801|Clostridia,260FF@186807|Peptococcaceae	186801|Clostridia	S	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes	larC	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
TH2_k127_3952258_5	1158345.JNLL01000001_gene551	1.838e-41	171.0	COG1538@1|root,COG1538@2|Bacteria,2G4Q7@200783|Aquificae	200783|Aquificae	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TH2_k127_3952258_0	768670.Calni_1895	6.732e-104	351.0	COG0845@1|root,COG0845@2|Bacteria,2GG9R@200930|Deferribacteres	200930|Deferribacteres	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
TH2_k127_3952258_2	103690.17135328	4.138e-80	273.0	COG1136@1|root,COG1136@2|Bacteria,1G1RM@1117|Cyanobacteria,1HQMT@1161|Nostocales	1117|Cyanobacteria	V	membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TH2_k127_3952258_6	269799.Gmet_0037	1.081e-39	152.0	COG3794@1|root,COG3794@2|Bacteria,1N0BX@1224|Proteobacteria,431VB@68525|delta/epsilon subdivisions,2WX3U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3952258_4	1304885.AUEY01000001_gene3309	7.094e-52	189.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,42S15@68525|delta/epsilon subdivisions,2WNI1@28221|Deltaproteobacteria,2MNGZ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
TH2_k127_3952258_8	1158292.JPOE01000005_gene704	2.071e-05	56.0	COG1704@1|root,COG1704@2|Bacteria,1RDUH@1224|Proteobacteria,2WGR6@28216|Betaproteobacteria	28216|Betaproteobacteria	S	E3 Ubiquitin ligase	-	-	-	-	-	-	-	-	-	-	-	-	GIDE
TH2_k127_3952258_7	118005.AWNK01000003_gene2253	3.988e-10	61.0	COG4231@1|root,COG4231@2|Bacteria	2|Bacteria	C	indolepyruvate ferredoxin oxidoreductase activity	iorA	-	1.2.7.8	ko:K00179,ko:K08941	-	M00598	-	-	br01601,ko00000,ko00002,ko00194,ko01000	-	-	-	Fer4,Fer4_10,POR_N,TPP_enzyme_C
TH2_k127_4000575_10	196367.JNFG01000202_gene2720	4.112e-23	102.0	COG4679@1|root,COG4679@2|Bacteria,1MZ3N@1224|Proteobacteria,2VV1A@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
TH2_k127_4000575_13	227377.CBU_1691	1.311e-07	58.0	COG1396@1|root,COG1396@2|Bacteria,1QWDJ@1224|Proteobacteria,1T3BW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
TH2_k127_4000575_15	247490.KSU1_D0176	0.0007961	44.0	COG1943@1|root,COG1943@2|Bacteria,2IYXS@203682|Planctomycetes	203682|Planctomycetes	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
TH2_k127_4000575_5	1123376.AUIU01000015_gene374	2.18e-50	190.0	COG1639@1|root,COG1639@2|Bacteria,3J0NC@40117|Nitrospirae	40117|Nitrospirae	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
TH2_k127_4000575_0	1123376.AUIU01000001_gene767	2.622e-296	934.0	COG0517@1|root,COG0617@1|root,COG0618@1|root,COG0517@2|Bacteria,COG0617@2|Bacteria,COG0618@2|Bacteria,3J0NX@40117|Nitrospirae	40117|Nitrospirae	J	Probable RNA and SrmB- binding site of polymerase A	-	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	CBS,DHH,DHHA1,PolyA_pol,PolyA_pol_RNAbd
TH2_k127_4000575_9	335543.Sfum_0360	1.874e-30	127.0	COG0789@1|root,COG0789@2|Bacteria,1NP97@1224|Proteobacteria,43DNH@68525|delta/epsilon subdivisions,2X38J@28221|Deltaproteobacteria,2MSE8@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Transcriptional regulator, MerR family	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
TH2_k127_4000575_1	289376.THEYE_A1652	1.025e-275	867.0	COG5009@1|root,COG5009@2|Bacteria,3J0BH@40117|Nitrospirae	40117|Nitrospirae	M	Penicillin-binding protein OB-like domain	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
TH2_k127_4000575_8	1122962.AULH01000013_gene494	4.519e-36	143.0	COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,2TRRN@28211|Alphaproteobacteria,36YKJ@31993|Methylocystaceae	28211|Alphaproteobacteria	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
TH2_k127_4000575_12	909663.KI867150_gene2243	1.269e-15	83.0	2B2YS@1|root,31VJR@2|Bacteria,1QTGD@1224|Proteobacteria,43F37@68525|delta/epsilon subdivisions,2X9RC@28221|Deltaproteobacteria,2MSAG@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4000575_4	289376.THEYE_A0619	1.821e-79	278.0	COG1639@1|root,COG1639@2|Bacteria,3J0NC@40117|Nitrospirae	40117|Nitrospirae	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
TH2_k127_4000575_11	671143.DAMO_1813	3.253e-21	102.0	COG2199@1|root,COG3706@2|Bacteria,2NPCY@2323|unclassified Bacteria	2|Bacteria	T	Diguanylate cyclase, GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,HATPase_c,HisKA,PAS,Response_reg
TH2_k127_4000575_7	641491.DND132_0226	4.249e-38	146.0	COG2199@1|root,COG3706@2|Bacteria,1QUKY@1224|Proteobacteria,42NYY@68525|delta/epsilon subdivisions,2WKIY@28221|Deltaproteobacteria,2M8WM@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
TH2_k127_4000575_2	289376.THEYE_A1257	2.802e-258	807.0	COG0058@1|root,COG0058@2|Bacteria,3J0W1@40117|Nitrospirae	40117|Nitrospirae	G	Carbohydrate phosphorylase	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
TH2_k127_4000575_3	1232410.KI421417_gene2744	8.202e-80	283.0	COG2107@1|root,COG2107@2|Bacteria,1NYEA@1224|Proteobacteria,42MXB@68525|delta/epsilon subdivisions,2WIMS@28221|Deltaproteobacteria,43TEZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnD	-	-	ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
TH2_k127_4000575_6	243233.MCA2561	5.892e-50	191.0	COG1216@1|root,COG4942@1|root,COG1216@2|Bacteria,COG4942@2|Bacteria,1MX5Z@1224|Proteobacteria	1224|Proteobacteria	J	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_WbsX,Glyco_transf_4,Glycos_transf_1,Glycos_transf_2
TH2_k127_4101366_10	335541.Swol_2225	3.443e-62	230.0	COG2265@1|root,COG2265@2|Bacteria,1TP4H@1239|Firmicutes,248B4@186801|Clostridia,42JNB@68298|Syntrophomonadaceae	186801|Clostridia	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
TH2_k127_4101366_11	289376.THEYE_A1490	1.446e-48	192.0	COG0745@1|root,COG0745@2|Bacteria	289376.THEYE_A1490|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4101366_0	289376.THEYE_A1491	1.333e-240	773.0	COG2203@1|root,COG3829@1|root,COG3852@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,COG3852@2|Bacteria,3J0YT@40117|Nitrospirae	40117|Nitrospirae	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_9
TH2_k127_4101366_3	289376.THEYE_A1492	1.511e-149	494.0	COG0297@1|root,COG0297@2|Bacteria,3J0DJ@40117|Nitrospirae	40117|Nitrospirae	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
TH2_k127_4101366_1	289376.THEYE_A1493	3.168e-178	562.0	COG1085@1|root,COG1085@2|Bacteria,3J0ER@40117|Nitrospirae	40117|Nitrospirae	H	Galactose-1-phosphate uridyl transferase, N-terminal domain	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
TH2_k127_4101366_6	289376.THEYE_A1494	2.153e-100	337.0	COG1234@1|root,COG1234@2|Bacteria,3J113@40117|Nitrospirae	40117|Nitrospirae	S	tRNA 3'-trailer cleavage	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	-
TH2_k127_4101366_5	289376.THEYE_A1499	1.479e-106	351.0	COG0496@1|root,COG0496@2|Bacteria,3J0IG@40117|Nitrospirae	40117|Nitrospirae	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
TH2_k127_4101366_7	1123376.AUIU01000015_gene479	1.132e-80	274.0	COG2518@1|root,COG2518@2|Bacteria	2|Bacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
TH2_k127_4101366_2	1304284.L21TH_2143	5.879e-157	506.0	COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24805@186801|Clostridia,36F8C@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily	rnfC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4,Fer4_10,Fer4_7,Fer4_9,RnfC_N,SLBB
TH2_k127_4101366_4	401526.TcarDRAFT_1671	7.495e-114	377.0	COG4658@1|root,COG4658@2|Bacteria,1TQAY@1239|Firmicutes,4H2AN@909932|Negativicutes	909932|Negativicutes	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
TH2_k127_4101366_12	401526.TcarDRAFT_1670	2.213e-28	124.0	COG4659@1|root,COG4659@2|Bacteria,1V7R1@1239|Firmicutes,4H4F7@909932|Negativicutes	909932|Negativicutes	C	Part of a membrane complex involved in electron transport	rnfG	-	-	ko:K03612	-	-	-	-	ko00000	-	-	-	FMN_bind
TH2_k127_4101366_9	765912.Thimo_0231	2.512e-63	224.0	COG4660@1|root,COG4660@2|Bacteria,1R342@1224|Proteobacteria,1T62W@1236|Gammaproteobacteria,1WW5Q@135613|Chromatiales	135613|Chromatiales	U	Part of a membrane complex involved in electron transport	-	-	-	ko:K03613	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
TH2_k127_4101366_8	706587.Desti_2906	5.231e-71	244.0	COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,42MCM@68525|delta/epsilon subdivisions,2WKRE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Part of a membrane complex involved in electron transport	rnfA	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
TH2_k127_4101366_13	335543.Sfum_2694	3.894e-19	91.0	COG1142@1|root,COG2878@1|root,COG1142@2|Bacteria,COG2878@2|Bacteria,1NZIR@1224|Proteobacteria,42PTG@68525|delta/epsilon subdivisions,2WKYG@28221|Deltaproteobacteria,2MQW2@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Putative Fe-S cluster	rnfB	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4,Fer4_7
TH2_k127_4108943_1	909663.KI867149_gene3438	1.04e-70	256.0	COG4968@1|root,COG4968@2|Bacteria,1REDT@1224|Proteobacteria,42RY5@68525|delta/epsilon subdivisions,2WNPG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	Prokaryotic N-terminal methylation motif	pilW-2	-	-	-	-	-	-	-	-	-	-	-	N_methyl,PilW
TH2_k127_4108943_2	243231.GSU2036	1.576e-16	85.0	COG4967@1|root,COG4967@2|Bacteria,1NHY3@1224|Proteobacteria,42WZH@68525|delta/epsilon subdivisions,2WSKR@28221|Deltaproteobacteria,43VUB@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	Pfam:N_methyl_2	pilV-2	-	-	ko:K02671	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	N_methyl
TH2_k127_4108943_3	243231.GSU2037	3.387e-15	86.0	COG4970@1|root,COG4970@2|Bacteria,1NGHS@1224|Proteobacteria,42XAP@68525|delta/epsilon subdivisions,2WSYI@28221|Deltaproteobacteria,43VQ5@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
TH2_k127_4108943_0	909663.KI867149_gene3441	1.242e-97	328.0	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,42NJ7@68525|delta/epsilon subdivisions,2WJYB@28221|Deltaproteobacteria,2MQNK@213462|Syntrophobacterales	28221|Deltaproteobacteria	NU	Neisseria PilC beta-propeller domain	-	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC
TH2_k127_4153771_4	1330700.JQNC01000003_gene667	1.057e-55	201.0	COG0157@1|root,COG0157@2|Bacteria,1WIHZ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
TH2_k127_4153771_0	1123376.AUIU01000014_gene680	0.0	1243.0	COG0525@1|root,COG0525@2|Bacteria,3J0B9@40117|Nitrospirae	40117|Nitrospirae	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
TH2_k127_4153771_3	246194.CHY_2198	3.155e-57	201.0	COG0822@1|root,COG0822@2|Bacteria,1V3H9@1239|Firmicutes,24HDD@186801|Clostridia,42GNH@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM FeS cluster assembly scaffold protein NifU	nifU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
TH2_k127_4153771_1	429009.Adeg_0423	5.81e-128	421.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,42FGX@68295|Thermoanaerobacterales	186801|Clostridia	H	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
TH2_k127_4153771_7	747365.Thena_0211	9.679e-23	106.0	COG0425@1|root,COG0425@2|Bacteria,1UF14@1239|Firmicutes,25K1R@186801|Clostridia,42IV0@68295|Thermoanaerobacterales	186801|Clostridia	O	Sulfurtransferase TusA	-	-	-	-	-	-	-	-	-	-	-	-	TusA
TH2_k127_4153771_6	1123373.ATXI01000010_gene1005	8.155e-39	149.0	COG1959@1|root,COG1959@2|Bacteria,2GGXM@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
TH2_k127_4153771_2	1337093.MBE-LCI_3166	1.741e-57	209.0	COG4783@1|root,COG4783@2|Bacteria,1QUMJ@1224|Proteobacteria,2TXU6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
TH2_k127_4414473_7	1449353.JQMQ01000004_gene6294	5.689e-33	129.0	COG3408@1|root,COG3408@2|Bacteria,2I2X5@201174|Actinobacteria	201174|Actinobacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
TH2_k127_4414473_0	1499967.BAYZ01000190_gene3817	4.976e-220	691.0	COG1249@1|root,COG1249@2|Bacteria	2|Bacteria	C	cell redox homeostasis	merA	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
TH2_k127_4414473_2	1121396.KB892918_gene90	2.524e-91	307.0	COG0398@1|root,COG0398@2|Bacteria,1MVF3@1224|Proteobacteria,42PFC@68525|delta/epsilon subdivisions,2WKDP@28221|Deltaproteobacteria,2MIRM@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TH2_k127_4414473_6	316067.Geob_0042	7.566e-52	186.0	COG0735@1|root,COG0735@2|Bacteria,1NJMI@1224|Proteobacteria	1224|Proteobacteria	K	Belongs to the Fur family	fur	GO:0000976,GO:0001067,GO:0001130,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141	-	ko:K02076,ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
TH2_k127_4414473_3	443144.GM21_3600	6.36e-87	299.0	COG0803@1|root,COG0803@2|Bacteria,1MVW9@1224|Proteobacteria,42MBX@68525|delta/epsilon subdivisions,2WQYR@28221|Deltaproteobacteria,43TDX@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Belongs to the bacterial solute-binding protein 9 family	acdA	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
TH2_k127_4414473_1	909663.KI867150_gene2624	1.351e-99	332.0	COG1121@1|root,COG1121@2|Bacteria,1MUDW@1224|Proteobacteria,42NI8@68525|delta/epsilon subdivisions,2WKMZ@28221|Deltaproteobacteria,2MRH2@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
TH2_k127_4414473_4	909663.KI867150_gene2625	4.13e-85	289.0	COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,42MYM@68525|delta/epsilon subdivisions,2WJAM@28221|Deltaproteobacteria,2MRBY@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	ABC 3 transport family	-	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
TH2_k127_4414473_5	552811.Dehly_1049	5.052e-52	193.0	COG0598@1|root,COG0598@2|Bacteria,2G8D8@200795|Chloroflexi,34D3E@301297|Dehalococcoidia	301297|Dehalococcoidia	P	CorA-like Mg2+ transporter protein	-	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
TH2_k127_4526881_2	289376.THEYE_A1688	1.092e-190	602.0	COG0070@1|root,COG0493@1|root,COG1143@1|root,COG0070@2|Bacteria,COG0493@2|Bacteria,COG1143@2|Bacteria,3J152@40117|Nitrospirae	40117|Nitrospirae	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_20,GXGXG,Pyr_redox_2,Pyr_redox_3
TH2_k127_4526881_0	289376.THEYE_A1687	1.25e-317	977.0	COG0069@1|root,COG1149@1|root,COG0069@2|Bacteria,COG1149@2|Bacteria,3J0SV@40117|Nitrospirae	40117|Nitrospirae	C	Conserved region in glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
TH2_k127_4526881_6	1121441.AUCX01000021_gene696	5.31e-114	378.0	COG0034@1|root,COG0034@2|Bacteria,1R0RJ@1224|Proteobacteria,43CZU@68525|delta/epsilon subdivisions,2X883@28221|Deltaproteobacteria,2MHCY@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4526881_5	289376.THEYE_A1849	6.619e-117	389.0	COG0467@1|root,COG1396@1|root,COG1917@1|root,COG0467@2|Bacteria,COG1396@2|Bacteria,COG1917@2|Bacteria,3J0VE@40117|Nitrospirae	40117|Nitrospirae	K	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3
TH2_k127_4526881_1	1123376.AUIU01000011_gene810	1.053e-276	857.0	COG1304@1|root,COG1304@2|Bacteria	2|Bacteria	C	FMN binding	yahG	-	-	-	-	-	-	-	-	-	-	-	DUF1116,FMN_dh,Glu_synthase
TH2_k127_4526881_4	909663.KI867150_gene1083	5.448e-118	389.0	COG1693@1|root,COG1693@2|Bacteria,1RAC2@1224|Proteobacteria,42QW9@68525|delta/epsilon subdivisions,2WMZV@28221|Deltaproteobacteria,2MQWZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Ribonuclease R winged-helix domain	-	-	-	ko:K09720	-	-	-	-	ko00000,ko03000	-	-	-	DUF128,HTH_12
TH2_k127_4526881_8	231434.JQJH01000014_gene1004	2.828e-49	177.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2U73Z@28211|Alphaproteobacteria,3NBAX@45404|Beijerinckiaceae	28211|Alphaproteobacteria	E	Nitrogen regulatory protein P-II	glnB	GO:0003674,GO:0006808,GO:0008150,GO:0030234,GO:0050789,GO:0050790,GO:0065007,GO:0065009,GO:0098772	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
TH2_k127_4526881_3	1499967.BAYZ01000119_gene3222	7.292e-183	583.0	COG0174@1|root,COG0174@2|Bacteria,2NNY0@2323|unclassified Bacteria	2|Bacteria	E	glutamine synthetase	glnA2	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
TH2_k127_4526881_7	1121423.JONT01000046_gene958	1.267e-103	347.0	COG1533@1|root,COG1533@2|Bacteria,1TQA6@1239|Firmicutes,24A2T@186801|Clostridia,261PN@186807|Peptococcaceae	186801|Clostridia	L	Domain of unknown function (DUF1848)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1848
TH2_k127_4563928_1	269799.Gmet_1993	6.686e-151	500.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1MU55@1224|Proteobacteria,42PTN@68525|delta/epsilon subdivisions,2WKBJ@28221|Deltaproteobacteria,43SC3@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_3,HATPase_c
TH2_k127_4563928_7	83406.HDN1F_33040	2.409e-10	70.0	COG5652@1|root,COG5652@2|Bacteria,1NGE7@1224|Proteobacteria,1SGEP@1236|Gammaproteobacteria,1JBHN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	PFAM VanZ	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
TH2_k127_4563928_2	335543.Sfum_2263	2.213e-133	432.0	COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,42MTN@68525|delta/epsilon subdivisions,2WJAI@28221|Deltaproteobacteria,2MQUJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rmlA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TH2_k127_4563928_4	335543.Sfum_0954	5.631e-44	171.0	COG1269@1|root,COG1269@2|Bacteria,1MXZG@1224|Proteobacteria,42R3N@68525|delta/epsilon subdivisions,2WMY8@28221|Deltaproteobacteria,2MSAZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	eight transmembrane protein EpsH	epsH	-	-	-	-	-	-	-	-	-	-	-	DUF3485,Exosortase_EpsH
TH2_k127_4563928_5	1121405.dsmv_1385	2.59e-40	164.0	COG5652@1|root,COG5652@2|Bacteria,1R7IX@1224|Proteobacteria	1224|Proteobacteria	S	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	DUF4962,Hepar_II_III,VanZ
TH2_k127_4563928_0	1125863.JAFN01000001_gene613	1.804e-276	857.0	COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,42M4F@68525|delta/epsilon subdivisions,2WKK3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM UDP-glucose GDP-mannose dehydrogenase	-	-	1.1.1.136	ko:K02474,ko:K13015	ko00520,map00520	-	R00421,R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
TH2_k127_4563928_6	1121430.JMLG01000020_gene1424	5.184e-20	94.0	COG1487@1|root,COG1487@2|Bacteria,1VNH4@1239|Firmicutes,24WP8@186801|Clostridia	186801|Clostridia	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TH2_k127_4563928_8	743299.Acife_1536	0.0006879	45.0	COG5450@1|root,COG5450@2|Bacteria,1QN0B@1224|Proteobacteria,1SHDA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Bacterial antitoxin of type II TA system, VapB	-	-	-	-	-	-	-	-	-	-	-	-	VapB_antitoxin
TH2_k127_4563928_3	316067.Geob_2951	2.084e-58	205.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WJ00@28221|Deltaproteobacteria,43UQW@69541|Desulfuromonadales	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
TH2_k127_4578502_1	1122947.FR7_2818	8.107e-84	282.0	COG1914@1|root,COG1914@2|Bacteria,1TPT1@1239|Firmicutes,4H27Z@909932|Negativicutes	909932|Negativicutes	P	Natural resistance-associated macrophage protein	-	-	-	ko:K03322	-	-	-	-	ko00000,ko02000	2.A.55.2.6,2.A.55.3	-	-	Nramp
TH2_k127_4578502_2	1313172.YM304_16590	6.774e-81	287.0	COG3291@1|root,COG3391@1|root,COG3291@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4578502_0	909663.KI867150_gene1835	3.928e-172	549.0	COG1896@1|root,COG1896@2|Bacteria,1NS5U@1224|Proteobacteria,42NW2@68525|delta/epsilon subdivisions,2WKUM@28221|Deltaproteobacteria,2MR31@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	HD domain	-	-	-	ko:K07023	-	-	-	-	ko00000	-	-	-	HD_3
TH2_k127_4578502_4	1047013.AQSP01000001_gene2022	7.052e-11	70.0	arCOG10401@1|root,2ZA7Y@2|Bacteria,2NRGQ@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4595347_3	526226.Gbro_2961	8.811e-16	79.0	COG5573@1|root,COG5573@2|Bacteria,2GY55@201174|Actinobacteria	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TH2_k127_4595347_0	1385517.N800_00445	3.161e-24	121.0	COG1404@1|root,COG4935@1|root,COG1404@2|Bacteria,COG4935@2|Bacteria,1PH1W@1224|Proteobacteria,1RRYP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Metallo-peptidase family M12	-	-	-	-	-	-	-	-	-	-	-	-	CBM_4_9,P_proprotein,Reprolysin_3,Reprolysin_4
TH2_k127_4595347_4	457570.Nther_0354	9.122e-15	89.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Beta_helix
TH2_k127_4595347_2	1089551.KE386572_gene4249	3.199e-16	93.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2TQUZ@28211|Alphaproteobacteria,4BPK2@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	C-terminal, D2-small domain, of ClpB protein	clpA	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
TH2_k127_4595347_5	632245.CLP_4396	2.321e-07	64.0	COG3284@1|root,COG3284@2|Bacteria,1VHQN@1239|Firmicutes,25EB0@186801|Clostridia,36UIY@31979|Clostridiaceae	186801|Clostridia	KQ	Sigma54 specific transcriptional regulator, Fis family	-	-	-	ko:K21405	-	-	-	-	ko00000,ko03000	-	-	-	GAF,HTH_8,PAS,PAS_9,Sigma54_activat
TH2_k127_4595347_1	335543.Sfum_0893	3.961e-24	103.0	COG0655@1|root,COG0655@2|Bacteria,1RD5X@1224|Proteobacteria,42T3S@68525|delta/epsilon subdivisions,2WN9W@28221|Deltaproteobacteria,2MQMP@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
TH2_k127_4604484_6	289376.THEYE_A0433	8.008e-144	462.0	COG0536@1|root,COG0536@2|Bacteria,3J0E3@40117|Nitrospirae	40117|Nitrospirae	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
TH2_k127_4604484_7	289376.THEYE_A0432	3.113e-133	436.0	COG0263@1|root,COG0263@2|Bacteria,3J0GU@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
TH2_k127_4604484_15	289376.THEYE_A0128	1.075e-20	96.0	COG4980@1|root,COG4980@2|Bacteria	2|Bacteria	D	gas vesicle protein	XK27_07760	-	-	-	-	-	-	-	-	-	-	-	YtxH
TH2_k127_4604484_0	243231.GSU0547	1.352e-236	755.0	COG1193@1|root,COG1193@2|Bacteria,1QUJI@1224|Proteobacteria,42P7P@68525|delta/epsilon subdivisions,2WK5H@28221|Deltaproteobacteria,43U0Y@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
TH2_k127_4604484_18	291985.CCSI01000003_gene37	6.06e-05	52.0	2AM82@1|root,31C2W@2|Bacteria,1P3W8@1224|Proteobacteria,2UVCJ@28211|Alphaproteobacteria,2KB9A@204457|Sphingomonadales	204457|Sphingomonadales	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
TH2_k127_4604484_2	289376.THEYE_A2099	4.369e-186	606.0	COG0751@1|root,COG0751@2|Bacteria,3J0F0@40117|Nitrospirae	40117|Nitrospirae	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
TH2_k127_4604484_4	717231.Flexsi_2029	1.758e-151	482.0	COG0752@1|root,COG0752@2|Bacteria,2GEZ4@200930|Deferribacteres	200930|Deferribacteres	J	Glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
TH2_k127_4604484_16	289376.THEYE_A0442	1.344e-12	69.0	COG2104@1|root,COG2104@2|Bacteria	2|Bacteria	H	thiamine diphosphate biosynthetic process	thiS	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
TH2_k127_4604484_8	289376.THEYE_A0443	3.049e-131	422.0	COG2022@1|root,COG2022@2|Bacteria,3J0EI@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG
TH2_k127_4604484_14	269799.Gmet_2935	1.707e-48	181.0	COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,42NTP@68525|delta/epsilon subdivisions,2WQME@28221|Deltaproteobacteria,43UPN@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	tenI	GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
TH2_k127_4604484_3	289376.THEYE_A0445	8.241e-182	577.0	COG0422@1|root,COG0422@2|Bacteria,3J0AY@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
TH2_k127_4604484_12	338966.Ppro_3008	7.942e-95	325.0	COG0784@1|root,COG2203@1|root,COG4191@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,42N46@68525|delta/epsilon subdivisions,2WJT4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,Response_reg
TH2_k127_4604484_5	1123376.AUIU01000004_gene1174	1.131e-144	467.0	COG0031@1|root,COG0031@2|Bacteria,3J0HD@40117|Nitrospirae	40117|Nitrospirae	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47	ko:K01738,ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TH2_k127_4604484_13	1183438.GKIL_0590	7.332e-73	270.0	COG0535@1|root,COG0535@2|Bacteria,1G18X@1117|Cyanobacteria	1117|Cyanobacteria	S	TIGRFAM radical SAM Cys-rich domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Fer4_12,Radical_SAM
TH2_k127_4604484_10	717231.Flexsi_2050	8.388e-116	397.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
TH2_k127_4604484_11	289376.THEYE_A0461	1.792e-102	352.0	COG0414@1|root,COG0414@2|Bacteria,3J0KR@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
TH2_k127_4604484_1	1449126.JQKL01000049_gene2648	9.927e-210	662.0	COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,248WY@186801|Clostridia,2697G@186813|unclassified Clostridiales	186801|Clostridia	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	4.1.1.61,4.1.1.98	ko:K03182,ko:K16239,ko:K16874	ko00130,ko00365,ko00627,ko01100,ko01110,ko01120,map00130,map00365,map00627,map01100,map01110,map01120	M00117	R01238,R04985,R04986,R10213	RC00391,RC03086	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
TH2_k127_4604484_9	1123376.AUIU01000012_gene1599	7.675e-122	402.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,3J0H2@40117|Nitrospirae	40117|Nitrospirae	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
TH2_k127_4604484_17	1173029.JH980292_gene710	1.508e-05	51.0	COG2199@1|root,COG3706@2|Bacteria,1G35Y@1117|Cyanobacteria,1H9VP@1150|Oscillatoriales	1117|Cyanobacteria	T	diguanylate cyclase	-	-	2.7.7.65	ko:K21020	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000	-	-	-	GGDEF,Response_reg
TH2_k127_4617151_6	1280953.HOC_00055	1.173e-93	322.0	COG0175@1|root,COG0175@2|Bacteria,1MXNT@1224|Proteobacteria,2U1TY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EH	COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase) FAD synthetase and related enzymes	-	-	-	ko:K19170	-	-	-	-	ko00000,ko02048	-	-	-	PAPS_reduct
TH2_k127_4617151_15	768671.ThimaDRAFT_0310	6.965e-53	198.0	COG3440@1|root,COG3440@2|Bacteria,1NE0N@1224|Proteobacteria,1RNM6@1236|Gammaproteobacteria,1WZSF@135613|Chromatiales	135613|Chromatiales	V	HNH endonuclease	-	-	-	ko:K07454	-	-	-	-	ko00000	-	-	-	HNH_2
TH2_k127_4617151_12	289376.THEYE_A0329	1.005e-61	220.0	COG0242@1|root,COG0242@2|Bacteria,3J0RI@40117|Nitrospirae	40117|Nitrospirae	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	-	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
TH2_k127_4617151_4	289376.THEYE_A0328	5.31e-106	353.0	COG0223@1|root,COG0223@2|Bacteria,3J0GW@40117|Nitrospirae	40117|Nitrospirae	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
TH2_k127_4617151_13	289376.THEYE_A0327	2.669e-59	212.0	COG1852@1|root,COG1852@2|Bacteria	2|Bacteria	S	Protein of unknown function DUF116	-	-	-	ko:K09729	-	-	-	-	ko00000	-	-	-	DUF116,polyprenyl_synt
TH2_k127_4617151_7	1120973.AQXL01000131_gene2133	3.981e-86	301.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1TP3N@1239|Firmicutes,4HBQ6@91061|Bacilli,2783U@186823|Alicyclobacillaceae	91061|Bacilli	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	sun	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
TH2_k127_4617151_22	888056.HMPREF9062_1850	8.673e-11	70.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4D3IX@85005|Actinomycetales	201174|Actinobacteria	KLT	serine threonine protein kinase	pknL	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
TH2_k127_4617151_9	289377.HL41_07515	6.543e-85	289.0	COG0036@1|root,COG0036@2|Bacteria,2GHB2@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	G	Ribulose-phosphate 3 epimerase family	-	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
TH2_k127_4617151_11	289376.THEYE_A0323	1.405e-67	244.0	COG0457@1|root,COG0457@2|Bacteria	289376.THEYE_A0323|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4617151_20	1322246.BN4_10359	4.752e-28	124.0	COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,42TIF@68525|delta/epsilon subdivisions,2WQC4@28221|Deltaproteobacteria,2MBN3@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA-2	-	2.7.8.41	ko:K08744	ko00564,ko01100,map00564,map01100	-	R02030	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TH2_k127_4617151_2	289376.THEYE_A0321	5.329e-132	437.0	COG1625@1|root,COG1625@2|Bacteria,3J0XK@40117|Nitrospirae	40117|Nitrospirae	C	Protein of unknown function (DUF512)	-	-	-	-	-	-	-	-	-	-	-	-	DUF512
TH2_k127_4617151_8	289376.THEYE_A0423	4.885e-85	289.0	COG0169@1|root,COG0169@2|Bacteria,3J0SM@40117|Nitrospirae	40117|Nitrospirae	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
TH2_k127_4617151_17	289376.THEYE_A0231	1.528e-45	170.0	COG1934@1|root,COG1934@2|Bacteria,3J1EG@40117|Nitrospirae	40117|Nitrospirae	S	OstA-like protein	-	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
TH2_k127_4617151_5	1123376.AUIU01000011_gene1092	4.767e-95	317.0	COG1137@1|root,COG1137@2|Bacteria,3J0GJ@40117|Nitrospirae	40117|Nitrospirae	S	ABC transporter	-	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
TH2_k127_4617151_1	289376.THEYE_A0233	1.272e-154	502.0	COG1508@1|root,COG1508@2|Bacteria,3J0AT@40117|Nitrospirae	40117|Nitrospirae	K	Sigma-54 factor, Activator interacting domain (AID)	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
TH2_k127_4617151_14	289376.THEYE_A0234	6.192e-54	196.0	COG1544@1|root,COG1544@2|Bacteria,3J0V7@40117|Nitrospirae	40117|Nitrospirae	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
TH2_k127_4617151_10	330214.NIDE1346	1.648e-74	259.0	COG1660@1|root,COG1660@2|Bacteria,3J0IK@40117|Nitrospirae	40117|Nitrospirae	S	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
TH2_k127_4617151_3	289376.THEYE_A1313	1.135e-114	381.0	COG1104@1|root,COG1104@2|Bacteria,3J0AX@40117|Nitrospirae	40117|Nitrospirae	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
TH2_k127_4617151_19	289376.THEYE_A0236	1.14e-36	142.0	COG0711@1|root,COG0711@2|Bacteria	2|Bacteria	C	ATP synthesis coupled proton transport	atpF	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0016020,GO:0016469,GO:0032991,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045259,GO:0045260,GO:0071944,GO:0098796,GO:0098797	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
TH2_k127_4617151_16	289376.THEYE_A0237	7.506e-51	187.0	COG0711@1|root,COG0711@2|Bacteria	2|Bacteria	C	ATP synthesis coupled proton transport	atpF	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02109,ko:K18682	ko00190,ko00195,ko01100,ko03018,map00190,map00195,map01100,map03018	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000,ko03019	3.A.2.1	-	-	ATP-synt_B
TH2_k127_4617151_18	289376.THEYE_A0238	1.37e-44	171.0	COG0712@1|root,COG0712@2|Bacteria,3J1BY@40117|Nitrospirae	40117|Nitrospirae	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
TH2_k127_4617151_0	289376.THEYE_A0239	1.852e-256	795.0	COG0056@1|root,COG0056@2|Bacteria,3J0CZ@40117|Nitrospirae	40117|Nitrospirae	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
TH2_k127_4660474_7	289376.THEYE_A0907	3.495e-36	138.0	COG1014@1|root,COG1014@2|Bacteria,3J0TG@40117|Nitrospirae	40117|Nitrospirae	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
TH2_k127_4660474_0	903818.KI912268_gene3327	7.678e-177	563.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cyt_bd_oxida_I,Cytochrome_CBB3
TH2_k127_4660474_9	289376.THEYE_A1235	1.289e-29	126.0	COG0789@1|root,COG0789@2|Bacteria,3J0VF@40117|Nitrospirae	40117|Nitrospirae	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
TH2_k127_4660474_10	1123376.AUIU01000014_gene727	7.632e-28	116.0	COG0776@1|root,COG0776@2|Bacteria,3J1CY@40117|Nitrospirae	40117|Nitrospirae	L	bacterial (prokaryotic) histone like domain	-	-	-	ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
TH2_k127_4660474_6	289376.THEYE_A0802	1.253e-36	142.0	COG1734@1|root,COG1734@2|Bacteria,3J0TH@40117|Nitrospirae	40117|Nitrospirae	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
TH2_k127_4660474_3	1227454.C446_02582	7.34e-57	208.0	COG1173@1|root,arCOG00748@2157|Archaea,2XUIX@28890|Euryarchaeota,23T5H@183963|Halobacteria	183963|Halobacteria	P	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TH2_k127_4660474_2	1111069.TCCBUS3UF1_6680	8.92e-70	247.0	COG0601@1|root,COG0601@2|Bacteria,1WIGY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02033,ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
TH2_k127_4660474_1	926561.KB900620_gene2911	5.978e-99	342.0	COG4166@1|root,COG4166@2|Bacteria,1TNYQ@1239|Firmicutes,25E4B@186801|Clostridia	186801|Clostridia	E	Family 5	-	-	-	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
TH2_k127_4660474_5	795359.TOPB45_0801	3.662e-40	154.0	COG2062@1|root,COG2062@2|Bacteria	2|Bacteria	T	phosphohistidine phosphatase, SixA	sixA	-	3.6.1.55	ko:K03574,ko:K08296	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	His_Phos_1
TH2_k127_4660474_8	693661.Arcve_0183	5.722e-33	132.0	COG3543@1|root,arCOG04456@2157|Archaea,2Y1EA@28890|Euryarchaeota,246IC@183980|Archaeoglobi	183980|Archaeoglobi	S	Protein of unknown function (DUF1284)	-	-	-	ko:K09706	-	-	-	-	ko00000	-	-	-	DUF1284
TH2_k127_4660474_4	289376.THEYE_A1072	1.423e-41	155.0	COG0557@1|root,COG0557@2|Bacteria,3J0ZJ@40117|Nitrospirae	40117|Nitrospirae	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
TH2_k127_4698991_7	289376.THEYE_A0003	4.148e-35	136.0	COG2920@1|root,COG2920@2|Bacteria	2|Bacteria	P	part of a sulfur-relay system	tusE	GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097163,GO:0140104,GO:1901360	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
TH2_k127_4698991_4	123214.PERMA_0513	1.914e-89	311.0	COG2204@1|root,COG2204@2|Bacteria,2G4HS@200783|Aquificae	200783|Aquificae	K	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
TH2_k127_4698991_5	1123376.AUIU01000016_gene286	6.743e-89	305.0	COG0482@1|root,COG0482@2|Bacteria,3J0KT@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	-	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
TH2_k127_4698991_2	1047013.AQSP01000124_gene2683	7.227e-128	439.0	COG0421@1|root,COG0421@2|Bacteria	2|Bacteria	E	spermidine synthase activity	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
TH2_k127_4698991_0	909663.KI867151_gene3153	5.635e-174	554.0	COG1379@1|root,COG1379@2|Bacteria,1QYWZ@1224|Proteobacteria,43CDU@68525|delta/epsilon subdivisions,2X7PS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4698991_6	1158345.JNLL01000001_gene1612	3.216e-75	263.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	yfbL	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
TH2_k127_4698991_1	289376.THEYE_A1742	1.042e-145	469.0	COG1060@1|root,COG1060@2|Bacteria	2|Bacteria	H	7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity	mqnE	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188	1.21.98.1,2.5.1.120,2.5.1.77	ko:K11779,ko:K11780,ko:K11781,ko:K11784,ko:K18285	ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120	M00378	R08588,R09396,R10667	RC00021,RC01381,RC02329,RC03002,RC03007,RC03234	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3391	Radical_SAM
TH2_k127_4698991_3	289376.THEYE_A1745	5.194e-121	395.0	COG1060@1|root,COG1060@2|Bacteria	2|Bacteria	H	7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity	mqnC	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188	1.21.98.1,2.5.1.120,2.5.1.77	ko:K11779,ko:K11780,ko:K11781,ko:K11784,ko:K18285	ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120	M00378	R08588,R09396,R10667	RC00021,RC01381,RC02329,RC03002,RC03007,RC03234	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
TH2_k127_4862178_0	1121440.AUMA01000011_gene2309	0.0	1058.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2M7WE@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
TH2_k127_4862178_6	289376.THEYE_A0220	8.896e-95	318.0	COG0603@1|root,COG0603@2|Bacteria,3J0NP@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
TH2_k127_4862178_10	289376.THEYE_A0221	1.463e-51	190.0	COG0344@1|root,COG0344@2|Bacteria,3J0PK@40117|Nitrospirae	40117|Nitrospirae	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
TH2_k127_4862178_11	330214.NIDE2558	8.313e-42	160.0	COG0558@1|root,COG0558@2|Bacteria,3J0NH@40117|Nitrospirae	40117|Nitrospirae	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TH2_k127_4862178_8	1158338.JNLJ01000001_gene670	1.129e-56	203.0	COG1778@1|root,COG1778@2|Bacteria,2G45K@200783|Aquificae	200783|Aquificae	S	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family	-	-	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_3
TH2_k127_4862178_1	289376.THEYE_A1953	4.836e-134	434.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,3J0GG@40117|Nitrospirae	40117|Nitrospirae	M	Belongs to the SIS family. GutQ KpsF subfamily	-	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
TH2_k127_4862178_3	443144.GM21_2612	4.432e-116	380.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,42M61@68525|delta/epsilon subdivisions,2WIXU@28221|Deltaproteobacteria,43TJ3@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	PFAM DAHP synthetase I KDSA	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
TH2_k127_4862178_4	289376.THEYE_A0607	1.761e-109	385.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,3J0J4@40117|Nitrospirae	40117|Nitrospirae	M	Lysin motif	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
TH2_k127_4862178_15	1121101.HMPREF1532_00877	1.221e-05	55.0	COG0457@1|root,COG0457@2|Bacteria,4PKF6@976|Bacteroidetes,2FNWT@200643|Bacteroidia,4ANQH@815|Bacteroidaceae	976|Bacteroidetes	S	Tetratricopeptide repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_16,TPR_21,TPR_6,TPR_7,TPR_8
TH2_k127_4862178_7	1123376.AUIU01000007_gene1191	2e-74	258.0	COG1387@1|root,COG1387@2|Bacteria	2|Bacteria	E	zinc ion binding	-	-	-	-	-	-	-	-	-	-	-	-	PHP
TH2_k127_4862178_14	1219084.AP014508_gene806	4.929e-06	52.0	COG2168@1|root,COG2168@2|Bacteria,2GDEY@200918|Thermotogae	200918|Thermotogae	P	sulfur relay protein TusB DsrH	-	-	-	ko:K07237	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DsrH
TH2_k127_4862178_16	864051.BurJ1DRAFT_3333	2.731e-05	51.0	COG2923@1|root,COG2923@2|Bacteria,1N8RV@1224|Proteobacteria,2VSQ5@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Sulfur relay protein TusC DsrF	-	-	-	ko:K07236	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DrsE
TH2_k127_4862178_17	1259795.ARJK01000003_gene1182	9.549e-05	48.0	COG1553@1|root,COG1553@2|Bacteria,1VG50@1239|Firmicutes,24R7R@186801|Clostridia,42H7U@68295|Thermoanaerobacterales	186801|Clostridia	P	DsrE/DsrF-like family	-	-	-	ko:K07235	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE
TH2_k127_4862178_12	932678.THERU_03875	1.934e-11	68.0	COG2361@1|root,COG2361@2|Bacteria,2G5GQ@200783|Aquificae	200783|Aquificae	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
TH2_k127_4862178_5	370438.PTH_2623	2.292e-107	357.0	COG2896@1|root,COG2896@2|Bacteria,1TP89@1239|Firmicutes,247PP@186801|Clostridia,260P7@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
TH2_k127_4862178_2	589865.DaAHT2_0550	4.468e-127	416.0	COG0303@1|root,COG0303@2|Bacteria,1QUKM@1224|Proteobacteria,42NTF@68525|delta/epsilon subdivisions,2X75Q@28221|Deltaproteobacteria,2MITK@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Probable molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
TH2_k127_4862178_9	1123023.JIAI01000029_gene4468	1.544e-55	210.0	COG0659@1|root,COG0659@2|Bacteria,2H1V9@201174|Actinobacteria	201174|Actinobacteria	P	Molybdate transporter of MFS superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_MOT1
TH2_k127_4862178_13	33035.JPJF01000009_gene1458	2.61e-07	53.0	COG2005@1|root,COG2005@2|Bacteria,1VFW6@1239|Firmicutes,24QTV@186801|Clostridia,3Y0TF@572511|Blautia	186801|Clostridia	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	ko:K02019	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,NTP_transf_3
TH2_k127_4869206_0	1232410.KI421413_gene620	1.148e-210	674.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,42NID@68525|delta/epsilon subdivisions,2WJ4P@28221|Deltaproteobacteria,43S91@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	C-terminal domain of tail specific protease (DUF3340)	prc	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DUF3340,PDZ,Peptidase_S41
TH2_k127_4869206_4	289376.THEYE_A1796	7.774e-142	462.0	COG0124@1|root,COG0124@2|Bacteria,3J0EC@40117|Nitrospirae	40117|Nitrospirae	J	Histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
TH2_k127_4869206_9	1123376.AUIU01000019_gene1282	5.022e-62	217.0	COG3599@1|root,COG3599@2|Bacteria,3J19M@40117|Nitrospirae	40117|Nitrospirae	D	DivIVA protein	-	-	-	ko:K04074	-	-	-	-	ko00000,ko03036	-	-	-	DivIVA
TH2_k127_4869206_12	289376.THEYE_A1798	3.966e-30	128.0	COG0762@1|root,COG0762@2|Bacteria,3J0U5@40117|Nitrospirae	40117|Nitrospirae	S	YGGT family	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
TH2_k127_4869206_6	289376.THEYE_A1799	1.448e-85	293.0	COG0345@1|root,COG0345@2|Bacteria,3J0N8@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
TH2_k127_4869206_8	289376.THEYE_A1800	5.658e-73	256.0	COG0325@1|root,COG0325@2|Bacteria,3J0RJ@40117|Nitrospirae	40117|Nitrospirae	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
TH2_k127_4869206_3	289376.THEYE_A1801	2.994e-145	481.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TH2_k127_4869206_5	289376.THEYE_A1802	8.718e-104	343.0	COG2204@1|root,COG2204@2|Bacteria,3J10B@40117|Nitrospirae	40117|Nitrospirae	T	Sigma-54 interaction domain	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH2_k127_4869206_7	289376.THEYE_A1802	5.744e-79	268.0	COG2204@1|root,COG2204@2|Bacteria,3J10B@40117|Nitrospirae	40117|Nitrospirae	T	Sigma-54 interaction domain	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH2_k127_4869206_13	289376.THEYE_A1803	9.171e-26	113.0	28U9C@1|root,2ZGEW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4869206_1	1123376.AUIU01000013_gene1914	4.08e-174	556.0	COG0436@1|root,COG0436@2|Bacteria,3J0G2@40117|Nitrospirae	40117|Nitrospirae	E	Aminotransferase class I and II	-	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TH2_k127_4869206_11	243274.THEMA_04595	1.932e-44	166.0	COG0801@1|root,COG0801@2|Bacteria,2GDA7@200918|Thermotogae	200918|Thermotogae	H	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	-	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM0041	HPPK
TH2_k127_4869206_10	289376.THEYE_A0136	1.405e-47	174.0	COG0432@1|root,COG0432@2|Bacteria,3J1CB@40117|Nitrospirae	40117|Nitrospirae	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
TH2_k127_4869206_2	477974.Daud_0348	8.791e-172	555.0	COG0517@1|root,COG1227@1|root,COG0517@2|Bacteria,COG1227@2|Bacteria,1TPH6@1239|Firmicutes,248RQ@186801|Clostridia,260EW@186807|Peptococcaceae	186801|Clostridia	C	DHHA2 domain	ppaC	-	3.6.1.1	ko:K15986	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	CBS,DHH,DHHA2,DRTGG
TH2_k127_4939289_6	1122978.AUFP01000003_gene587	4.218e-20	91.0	COG0381@1|root,COG0381@2|Bacteria,4NGBD@976|Bacteroidetes,2FM5D@200643|Bacteroidia	976|Bacteroidetes	M	UDP-N-acetylglucosamine 2-epimerase	-	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
TH2_k127_4939289_4	935948.KE386495_gene2047	1.532e-31	139.0	COG2327@1|root,COG2327@2|Bacteria,1TPTI@1239|Firmicutes,248QN@186801|Clostridia,42FXY@68295|Thermoanaerobacterales	186801|Clostridia	S	TIGRFAM polysaccharide pyruvyl transferase CsaB	csaB	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,PS_pyruv_trans
TH2_k127_4939289_1	160799.PBOR_33155	1.592e-56	228.0	COG0438@1|root,COG0438@2|Bacteria,1VWC5@1239|Firmicutes	1239|Firmicutes	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4939289_3	290397.Adeh_2459	9.183e-54	218.0	COG0438@1|root,COG4106@1|root,COG0438@2|Bacteria,COG4106@2|Bacteria,1QU2N@1224|Proteobacteria,42PY5@68525|delta/epsilon subdivisions,2WIU8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
TH2_k127_4939289_0	304371.MCP_0236	4.6e-90	337.0	COG0438@1|root,arCOG01409@2157|Archaea	2157|Archaea	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1
TH2_k127_4939289_7	469382.Hbor_02670	3.867e-12	81.0	COG4124@1|root,arCOG09119@2157|Archaea,2XW5N@28890|Euryarchaeota,23TM6@183963|Halobacteria	183963|Halobacteria	G	COG4124 Beta-mannanase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_26
TH2_k127_4939289_8	1121920.AUAU01000006_gene323	2.133e-06	62.0	COG2706@1|root,COG2706@2|Bacteria	2|Bacteria	G	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,HemolysinCabind,VCBS
TH2_k127_4939289_5	1385517.N800_00445	4.104e-24	120.0	COG1404@1|root,COG4935@1|root,COG1404@2|Bacteria,COG4935@2|Bacteria,1PH1W@1224|Proteobacteria,1RRYP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Metallo-peptidase family M12	-	-	-	-	-	-	-	-	-	-	-	-	CBM_4_9,P_proprotein,Reprolysin_3,Reprolysin_4
TH2_k127_4939289_2	1125863.JAFN01000001_gene2355	1.019e-54	211.0	COG3210@1|root,COG5492@1|root,COG3210@2|Bacteria,COG5492@2|Bacteria,1PFJ7@1224|Proteobacteria,42WVE@68525|delta/epsilon subdivisions	1224|Proteobacteria	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4941233_5	289376.THEYE_A0725	1.683e-21	95.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	ntrX	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH2_k127_4941233_4	398767.Glov_1101	2.117e-24	115.0	COG2159@1|root,COG2159@2|Bacteria,1R7E1@1224|Proteobacteria	1224|Proteobacteria	S	PFAM Amidohydrolase 2	uxuA	-	4.2.1.8	ko:K01686	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
TH2_k127_4941233_6	233412.HD_1810	1.723e-08	58.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,1S5WR@1236|Gammaproteobacteria,1Y8UN@135625|Pasteurellales	135625|Pasteurellales	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
TH2_k127_4941233_7	686578.AFFX01000008_gene2757	6.976e-08	58.0	COG3118@1|root,COG3118@2|Bacteria,1RHUA@1224|Proteobacteria,1S64W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Thioredoxin	trxC	-	1.8.1.8	ko:K03672	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Thioredoxin
TH2_k127_4941233_1	388399.SSE37_13131	4.362e-129	450.0	COG1075@1|root,COG4995@1|root,COG1075@2|Bacteria,COG4995@2|Bacteria,1MUIQ@1224|Proteobacteria,2U1J0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,LCAT
TH2_k127_4941233_2	335543.Sfum_2818	1.489e-116	384.0	28K4S@1|root,2Z9TM@2|Bacteria,1N4AQ@1224|Proteobacteria,42PSN@68525|delta/epsilon subdivisions,2WNF4@28221|Deltaproteobacteria,2MRVW@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4941233_3	671143.DAMO_1957	2.468e-81	285.0	COG1136@1|root,COG1136@2|Bacteria,2NP53@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TH2_k127_4941233_0	243231.GSU1260	2.474e-161	515.0	COG4591@1|root,COG4591@2|Bacteria,1QVSQ@1224|Proteobacteria,43BSZ@68525|delta/epsilon subdivisions,2WME9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TH2_k127_4961058_11	243231.GSU1444	3.525e-77	270.0	COG2984@1|root,COG2984@2|Bacteria,1Q1HH@1224|Proteobacteria,42UE1@68525|delta/epsilon subdivisions,2WR33@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
TH2_k127_4961058_1	269799.Gmet_1243	2.121e-189	612.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,43VZ7@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Domains HAMP, HisKA, HATPase_c, REC	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	GAF,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,PocR,Response_reg,sCache_2
TH2_k127_4961058_7	243231.GSU1891	8.771e-123	404.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42QB7@68525|delta/epsilon subdivisions,2WM6Y@28221|Deltaproteobacteria,43UAJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,Response_reg
TH2_k127_4961058_0	289376.THEYE_A1292	4.591e-202	643.0	COG2262@1|root,COG2262@2|Bacteria,3J0AE@40117|Nitrospirae	40117|Nitrospirae	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
TH2_k127_4961058_2	589865.DaAHT2_1941	2.167e-185	584.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,42M55@68525|delta/epsilon subdivisions,2WIKM@28221|Deltaproteobacteria,2MJ60@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Radical SAM domain protein	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
TH2_k127_4961058_6	1121403.AUCV01000012_gene4020	1.409e-125	411.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,42MV9@68525|delta/epsilon subdivisions,2WJZK@28221|Deltaproteobacteria,2MP6C@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0016	URO-D
TH2_k127_4961058_9	289376.THEYE_A0805	2.31e-99	327.0	COG0299@1|root,COG0299@2|Bacteria,3J0MC@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
TH2_k127_4961058_15	1278073.MYSTI_04548	9e-31	130.0	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,42U1F@68525|delta/epsilon subdivisions,2WQQM@28221|Deltaproteobacteria,2YVK3@29|Myxococcales	28221|Deltaproteobacteria	L	Conserved hypothetical protein 95	-	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
TH2_k127_4961058_13	1379281.AVAG01000009_gene607	6.624e-53	194.0	COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,42RJQ@68525|delta/epsilon subdivisions,2WNDS@28221|Deltaproteobacteria,2MBFU@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
TH2_k127_4961058_12	1125863.JAFN01000001_gene2047	2.215e-61	216.0	COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,42SXB@68525|delta/epsilon subdivisions,2WPP2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	PFAM Isochorismatase	-	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
TH2_k127_4961058_3	909663.KI867150_gene1368	1.444e-158	514.0	COG0539@1|root,COG0539@2|Bacteria,1N2EJ@1224|Proteobacteria,42NXS@68525|delta/epsilon subdivisions,2WJ0A@28221|Deltaproteobacteria,2MRA1@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Ribosomal protein S1-like RNA-binding domain	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
TH2_k127_4961058_14	1047013.AQSP01000122_gene2257	4.677e-42	158.0	COG1186@1|root,COG1186@2|Bacteria	2|Bacteria	J	translation release factor activity	prfA3	-	-	-	-	-	-	-	-	-	-	-	RF-1
TH2_k127_4961058_17	335543.Sfum_3068	1.745e-15	90.0	COG1996@1|root,COG1996@2|Bacteria,1R71V@1224|Proteobacteria,42PRX@68525|delta/epsilon subdivisions,2WMQY@28221|Deltaproteobacteria,2MRMJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4961058_8	1121403.AUCV01000024_gene3444	1.198e-121	404.0	COG4260@1|root,COG4260@2|Bacteria,1MXTD@1224|Proteobacteria,42P7D@68525|delta/epsilon subdivisions,2WJ6S@28221|Deltaproteobacteria,2MIXK@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM SPFH domain Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DZR,SHOCT,zinc_ribbon_2
TH2_k127_4961058_4	316067.Geob_1944	3.315e-140	462.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,43T1R@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
TH2_k127_4961058_5	56780.SYN_00385	8.075e-127	413.0	COG4313@1|root,COG4313@2|Bacteria,1PC95@1224|Proteobacteria,42RHY@68525|delta/epsilon subdivisions,2WNBQ@28221|Deltaproteobacteria,2MRP0@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
TH2_k127_4961058_18	1123502.AQXD01000003_gene1514	6.281e-10	69.0	COG0741@1|root,COG0741@2|Bacteria,1R666@1224|Proteobacteria,1S3XT@1236|Gammaproteobacteria,1X6G6@135614|Xanthomonadales	135614|Xanthomonadales	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
TH2_k127_4961058_10	1121904.ARBP01000009_gene4301	4.869e-79	273.0	COG3016@1|root,COG3016@2|Bacteria,4NEQ4@976|Bacteroidetes,47MCF@768503|Cytophagia	976|Bacteroidetes	S	Haem-binding uptake, Tiki superfamily, ChaN	-	-	-	-	-	-	-	-	-	-	-	-	Cofac_haem_bdg
TH2_k127_4961058_16	1158338.JNLJ01000001_gene366	9.276e-19	95.0	COG3654@1|root,COG3654@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07341	-	-	-	-	ko00000,ko02048	-	-	-	Fic
TH2_k127_4961058_19	313628.LNTAR_15392	0.0003087	50.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	int	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
TH2_k127_5030272_4	1304885.AUEY01000052_gene1548	9.521e-111	369.0	COG1538@1|root,COG1538@2|Bacteria,1PCPQ@1224|Proteobacteria,42PZ3@68525|delta/epsilon subdivisions,2WJU4@28221|Deltaproteobacteria,2MIHB@213118|Desulfobacterales	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TH2_k127_5030272_3	1304885.AUEY01000052_gene1547	5.309e-122	403.0	COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,42PKU@68525|delta/epsilon subdivisions,2WM5K@28221|Deltaproteobacteria,2MIM9@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07798,ko:K15727	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1,8.A.1.2.1	-	-	DUF3347,HlyD_D23
TH2_k127_5030272_0	1304885.AUEY01000031_gene51	0.0	1614.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria,2MI5E@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	iAF987.Gmet_1547	ACR_tran
TH2_k127_5030272_5	398767.Glov_0123	2.763e-77	262.0	COG0778@1|root,COG0778@2|Bacteria,1MZN8@1224|Proteobacteria,42SJF@68525|delta/epsilon subdivisions,2WP4X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TH2_k127_5030272_7	323848.Nmul_A2076	1.331e-20	98.0	2AH4X@1|root,317EK@2|Bacteria,1RHUE@1224|Proteobacteria,2W344@28216|Betaproteobacteria,3735E@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5030272_1	886293.Sinac_3051	2.364e-245	789.0	COG0443@1|root,COG0443@2|Bacteria,2IXEC@203682|Planctomycetes	203682|Planctomycetes	O	Belongs to the heat shock protein 70 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3731,HSP70
TH2_k127_5030272_2	886293.Sinac_2984	1.229e-202	647.0	COG0443@1|root,COG0443@2|Bacteria,2IYH8@203682|Planctomycetes	203682|Planctomycetes	O	Heat shock protein 70 family	-	-	-	-	-	-	-	-	-	-	-	-	HSP70
TH2_k127_5030272_6	404589.Anae109_3014	1.089e-39	156.0	2CNUX@1|root,32SHU@2|Bacteria,1REYT@1224|Proteobacteria,42R1S@68525|delta/epsilon subdivisions,2WMRC@28221|Deltaproteobacteria,2YVEV@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF2760)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2760
TH2_k127_5055329_18	795359.TOPB45_0746	6.787e-20	89.0	COG4087@1|root,COG4087@2|Bacteria,2GHZ6@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Haloacid dehalogenase domain protein hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase
TH2_k127_5055329_1	1283300.ATXB01000001_gene665	1.994e-226	709.0	COG0297@1|root,COG0297@2|Bacteria,1P7F2@1224|Proteobacteria,1RZVJ@1236|Gammaproteobacteria,1XG73@135618|Methylococcales	135618|Methylococcales	G	Starch synthase catalytic domain	-	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009011,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046527,GO:0055114,GO:0071704,GO:1901576	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
TH2_k127_5055329_14	1267535.KB906767_gene5521	3.022e-37	151.0	COG1678@1|root,COG1678@2|Bacteria,3Y8TX@57723|Acidobacteria	57723|Acidobacteria	K	Uncharacterized ACR, COG1678	-	-	-	-	-	-	-	-	-	-	-	-	DUF179
TH2_k127_5055329_3	370438.PTH_2228	4.855e-186	596.0	COG1543@1|root,COG1543@2|Bacteria,1TPFX@1239|Firmicutes,248UF@186801|Clostridia,25ZYE@186807|Peptococcaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 57 family	-	-	2.4.1.18	ko:K16149	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000	-	GH57	-	DUF1957,Glyco_hydro_57
TH2_k127_5055329_23	105559.Nwat_0083	2.613e-07	62.0	COG3330@1|root,COG3330@2|Bacteria,1P8BB@1224|Proteobacteria,1SV0Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4912)	-	-	-	ko:K09942	-	-	-	-	ko00000	-	-	-	DUF4912
TH2_k127_5055329_5	1283300.ATXB01000001_gene664	3.407e-171	550.0	COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,1RYKS@1236|Gammaproteobacteria,1XFWC@135618|Methylococcales	135618|Methylococcales	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	hDGE_amylase
TH2_k127_5055329_20	76114.ebB139	4.009e-13	74.0	2E7KC@1|root,3025Q@2|Bacteria,1PUPZ@1224|Proteobacteria,2VXH0@28216|Betaproteobacteria,2KZAR@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5055329_16	304371.MCP_0027	1.742e-31	139.0	COG1032@1|root,arCOG01356@2157|Archaea	2157|Archaea	C	SMART Elongator protein 3 MiaB NifB	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
TH2_k127_5055329_7	595460.RRSWK_00838	4.176e-117	391.0	COG0626@1|root,COG0626@2|Bacteria,2IYGK@203682|Planctomycetes	203682|Planctomycetes	E	Cys Met metabolism	-	-	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
TH2_k127_5055329_2	324602.Caur_1947	1.675e-197	625.0	COG0498@1|root,COG0498@2|Bacteria,2G66Y@200795|Chloroflexi,375PP@32061|Chloroflexia	32061|Chloroflexia	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TH2_k127_5055329_8	269799.Gmet_2812	2.495e-95	323.0	COG0524@1|root,COG0524@2|Bacteria,1MUUC@1224|Proteobacteria,42M1U@68525|delta/epsilon subdivisions,2WKK5@28221|Deltaproteobacteria,43USS@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	pfkB family carbohydrate kinase	-	-	2.7.1.15,2.7.1.4	ko:K00847,ko:K00852	ko00030,ko00051,ko00500,ko00520,ko01100,map00030,map00051,map00500,map00520,map01100	-	R00760,R00867,R01051,R02750,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
TH2_k127_5055329_9	1379281.AVAG01000011_gene1275	2.44e-93	321.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,42P92@68525|delta/epsilon subdivisions,2WKXT@28221|Deltaproteobacteria,2MA2T@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
TH2_k127_5055329_13	237368.SCABRO_03027	3.559e-57	203.0	COG0426@1|root,COG0426@2|Bacteria	2|Bacteria	C	nitric oxide reductase activity	dfa1	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct,Flavodoxin_1,Lactamase_B
TH2_k127_5055329_17	945712.CULC22_02212	1.486e-23	106.0	COG3824@1|root,COG3824@2|Bacteria,2IKXW@201174|Actinobacteria,22NFJ@1653|Corynebacteriaceae	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
TH2_k127_5055329_22	857087.Metme_3355	1.611e-09	61.0	2AEIT@1|root,314E9@2|Bacteria,1QIXM@1224|Proteobacteria,1TGU1@1236|Gammaproteobacteria,1XGP6@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5055329_19	710686.Mycsm_05206	5.839e-17	87.0	2AVF8@1|root,31M78@2|Bacteria,2IMSU@201174|Actinobacteria,23A1M@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5055329_0	192952.MM_2340	5.057e-243	763.0	COG0028@1|root,arCOG02002@2157|Archaea,2XT1P@28890|Euryarchaeota	28890|Euryarchaeota	E	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TH2_k127_5055329_4	192952.MM_2341	1.034e-175	563.0	COG1012@1|root,arCOG01252@2157|Archaea,2XT1Y@28890|Euryarchaeota,2NA9G@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Aldehyde dehydrogenase	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2542	Aldedh
TH2_k127_5055329_21	1167006.UWK_00767	1.106e-09	61.0	COG1141@1|root,COG1141@2|Bacteria	2|Bacteria	C	electron transfer activity	-	-	-	ko:K05337,ko:K17247	-	-	-	-	ko00000	-	-	-	Fer4_13,Ferric_reduct
TH2_k127_5055329_15	335543.Sfum_1406	5.403e-34	131.0	COG4118@1|root,COG4118@2|Bacteria,1Q43S@1224|Proteobacteria,42VPT@68525|delta/epsilon subdivisions,2WS3C@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
TH2_k127_5055329_12	335543.Sfum_1407	6.808e-60	210.0	COG4113@1|root,COG4113@2|Bacteria,1N96B@1224|Proteobacteria,42TZ7@68525|delta/epsilon subdivisions,2WR0Y@28221|Deltaproteobacteria,2MS1K@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TH2_k127_5055329_11	240292.Ava_3892	1.174e-68	239.0	COG2135@1|root,COG2135@2|Bacteria,1G1SA@1117|Cyanobacteria,1HM2J@1161|Nostocales	1117|Cyanobacteria	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
TH2_k127_5055329_6	879212.DespoDRAFT_00335	7.194e-125	411.0	COG0582@1|root,COG3585@1|root,COG0582@2|Bacteria,COG3585@2|Bacteria,1N68Q@1224|Proteobacteria,42PMW@68525|delta/epsilon subdivisions,2WKG3@28221|Deltaproteobacteria,2MJFF@213118|Desulfobacterales	28221|Deltaproteobacteria	HL	TOBE domain	-	-	-	ko:K02019	-	-	-	-	ko00000,ko03000	-	-	-	Phage_integrase,TOBE
TH2_k127_5055329_10	767817.Desgi_2793	4.978e-93	310.0	COG0730@1|root,COG0730@2|Bacteria,1TST0@1239|Firmicutes,24B4S@186801|Clostridia,260G8@186807|Peptococcaceae	186801|Clostridia	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TH2_k127_5064828_12	1379281.AVAG01000108_gene241	4.67e-15	74.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2WJ2B@28221|Deltaproteobacteria,2M88A@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
TH2_k127_5064828_10	234267.Acid_6323	8.707e-17	82.0	COG0267@1|root,COG0267@2|Bacteria,3Y5UB@57723|Acidobacteria	57723|Acidobacteria	J	structural constituent of ribosome	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
TH2_k127_5064828_11	289376.THEYE_A1353	1.367e-16	80.0	COG0690@1|root,COG0690@2|Bacteria	2|Bacteria	U	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	secE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
TH2_k127_5064828_4	289376.THEYE_A1352	1.854e-81	273.0	COG0250@1|root,COG0250@2|Bacteria,3J0JA@40117|Nitrospirae	40117|Nitrospirae	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
TH2_k127_5064828_5	289376.THEYE_A1351	1.542e-69	237.0	COG0080@1|root,COG0080@2|Bacteria,3J0K2@40117|Nitrospirae	40117|Nitrospirae	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
TH2_k127_5064828_2	289376.THEYE_A1350	1.291e-113	369.0	COG0081@1|root,COG0081@2|Bacteria,3J0GB@40117|Nitrospirae	40117|Nitrospirae	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
TH2_k127_5064828_8	760568.Desku_3067	1.56e-35	143.0	COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes,24G9R@186801|Clostridia,261MK@186807|Peptococcaceae	186801|Clostridia	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
TH2_k127_5064828_6	289376.THEYE_A1348	6.315e-53	189.0	COG0222@1|root,COG0222@2|Bacteria,3J0NQ@40117|Nitrospirae	40117|Nitrospirae	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
TH2_k127_5064828_1	289376.THEYE_A1347	0.0	2002.0	COG0085@1|root,COG0085@2|Bacteria,3J0CW@40117|Nitrospirae	40117|Nitrospirae	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
TH2_k127_5064828_0	289376.THEYE_A1346	0.0	2211.0	COG0086@1|root,COG0086@2|Bacteria,3J0BT@40117|Nitrospirae	40117|Nitrospirae	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
TH2_k127_5064828_7	1123376.AUIU01000012_gene1616	5.24e-36	144.0	COG1656@1|root,COG1656@2|Bacteria	2|Bacteria	F	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C,Ub-Mut7C
TH2_k127_5064828_3	289376.THEYE_A0825	2.643e-109	366.0	COG0490@1|root,COG1226@1|root,COG0490@2|Bacteria,COG1226@2|Bacteria,3J12F@40117|Nitrospirae	40117|Nitrospirae	P	TrkA-N domain	-	-	-	ko:K03455,ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6,2.A.37	-	-	Ion_trans_2,TrkA_C,TrkA_N
TH2_k127_5064828_9	458817.Shal_1180	1.802e-22	105.0	2C852@1|root,32YB2@2|Bacteria,1N9HY@1224|Proteobacteria,1SCRT@1236|Gammaproteobacteria,2QA0N@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
TH2_k127_5119696_7	1232437.KL661969_gene4926	5.128e-06	56.0	COG2199@1|root,COG4191@1|root,COG3706@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43CB6@68525|delta/epsilon subdivisions,2X806@28221|Deltaproteobacteria,2MPMT@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TH2_k127_5119696_6	1121866.AUGK01000002_gene1653	2.205e-09	62.0	COG0298@1|root,COG0298@2|Bacteria	2|Bacteria	O	carbon dioxide binding	hypC	-	-	ko:K04653,ko:K04654	-	-	-	-	ko00000	-	-	iHN637.CLJU_RS11355	HupF_HypC
TH2_k127_5119696_3	289376.THEYE_A1941	2.308e-46	172.0	COG0680@1|root,COG0680@2|Bacteria,3J16R@40117|Nitrospirae	40117|Nitrospirae	C	Hydrogenase maturation protease	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
TH2_k127_5119696_2	1121918.ARWE01000001_gene3503	1.364e-59	213.0	COG1969@1|root,COG1969@2|Bacteria,1MU87@1224|Proteobacteria,42NQ3@68525|delta/epsilon subdivisions,2X8MJ@28221|Deltaproteobacteria,43TMS@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Domain of unknown function (DUF4405)	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
TH2_k127_5119696_0	269799.Gmet_3331	8.388e-240	749.0	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,42M4S@68525|delta/epsilon subdivisions,2WJQS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	hyaL	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
TH2_k127_5119696_5	1123372.AUIT01000003_gene845	2.768e-28	114.0	COG0374@1|root,COG0374@2|Bacteria,2GH4N@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Nickel-dependent hydrogenase	-	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
TH2_k127_5119696_1	1232410.KI421412_gene147	1.025e-146	473.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,42MI0@68525|delta/epsilon subdivisions,2WIW4@28221|Deltaproteobacteria,43TJR@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	NiFe/NiFeSe hydrogenase small subunit C-terminal	hyaS	-	1.12.2.1,1.12.99.6	ko:K06282,ko:K18008	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_3332	NiFe_hyd_SSU_C,Oxidored_q6,TAT_signal
TH2_k127_5119696_4	1131269.AQVV01000009_gene1155	2.874e-45	175.0	2DM57@1|root,31S0Y@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5222561_7	335543.Sfum_3420	8.761e-17	80.0	COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,42NFH@68525|delta/epsilon subdivisions,2WNBD@28221|Deltaproteobacteria,2MQQ3@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TH2_k127_5222561_5	330214.NIDE3770	2.983e-79	277.0	COG3173@1|root,COG3173@2|Bacteria	2|Bacteria	S	very-long-chain-acyl-CoA dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	APH
TH2_k127_5222561_2	880072.Desac_2570	3.692e-119	390.0	COG0524@1|root,COG0524@2|Bacteria,1QMIR@1224|Proteobacteria,42NDK@68525|delta/epsilon subdivisions,2WK15@28221|Deltaproteobacteria,2MR2Z@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	PFAM PfkB	-	-	2.7.1.20	ko:K00856	ko00230,ko01100,map00230,map01100	-	R00185	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
TH2_k127_5222561_0	289376.THEYE_A1889	3.253e-192	618.0	COG0322@1|root,COG0322@2|Bacteria,3J0F1@40117|Nitrospirae	40117|Nitrospirae	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_5,UVR,UvrC_HhH_N
TH2_k127_5222561_3	883.DvMF_0337	4.564e-87	295.0	COG0204@1|root,COG0204@2|Bacteria,1PY44@1224|Proteobacteria,42NR4@68525|delta/epsilon subdivisions,2WKKQ@28221|Deltaproteobacteria,2MAGC@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	PFAM Phospholipid glycerol acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TH2_k127_5222561_1	1499967.BAYZ01000076_gene816	1.969e-150	484.0	COG1064@1|root,COG1064@2|Bacteria,2NP06@2323|unclassified Bacteria	2|Bacteria	S	Alcohol dehydrogenase GroES-like domain	adhA	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TH2_k127_5222561_4	96561.Dole_1467	6.67e-84	288.0	COG1090@1|root,COG1090@2|Bacteria,1MUB4@1224|Proteobacteria,42QUU@68525|delta/epsilon subdivisions,2WKRY@28221|Deltaproteobacteria,2MJ1I@213118|Desulfobacterales	28221|Deltaproteobacteria	S	epimerase dehydratase	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
TH2_k127_5222561_6	289376.THEYE_A0509	1.118e-41	158.0	2BVIG@1|root,32QWN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5227263_20	1123376.AUIU01000007_gene1193	2.027e-84	287.0	COG0177@1|root,COG0177@2|Bacteria,3J0K6@40117|Nitrospirae	40117|Nitrospirae	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
TH2_k127_5227263_26	289376.THEYE_A1823	6.335e-35	134.0	COG0776@1|root,COG0776@2|Bacteria,3J0V6@40117|Nitrospirae	40117|Nitrospirae	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
TH2_k127_5227263_27	1123376.AUIU01000011_gene1003	2.802e-34	134.0	COG0011@1|root,COG0011@2|Bacteria,3J0QD@40117|Nitrospirae	40117|Nitrospirae	S	Thiamine-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Thiamine_BP
TH2_k127_5227263_21	589865.DaAHT2_0147	1.03e-83	287.0	COG0492@1|root,COG0492@2|Bacteria,1MVWS@1224|Proteobacteria,42YY5@68525|delta/epsilon subdivisions,2WPYC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TH2_k127_5227263_10	1123376.AUIU01000016_gene231	5.682e-135	448.0	COG5002@1|root,COG5002@2|Bacteria,3J10G@40117|Nitrospirae	40117|Nitrospirae	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K07711	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
TH2_k127_5227263_4	1123376.AUIU01000016_gene233	1.366e-192	612.0	COG2204@1|root,COG2204@2|Bacteria,3J0ZU@40117|Nitrospirae	40117|Nitrospirae	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K07715	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH2_k127_5227263_1	1123376.AUIU01000014_gene629	2.586e-297	926.0	COG0317@1|root,COG0317@2|Bacteria,3J0CX@40117|Nitrospirae	40117|Nitrospirae	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
TH2_k127_5227263_7	289376.THEYE_A1008	9.687e-171	546.0	COG0766@1|root,COG0766@2|Bacteria,3J0EE@40117|Nitrospirae	40117|Nitrospirae	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
TH2_k127_5227263_16	639030.JHVA01000001_gene1345	3.126e-101	351.0	COG0323@1|root,COG0323@2|Bacteria,3Y2T3@57723|Acidobacteria,2JI29@204432|Acidobacteriia	204432|Acidobacteriia	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
TH2_k127_5227263_8	289376.THEYE_A1971	8.264e-145	466.0	COG0674@1|root,COG0674@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	vorA	-	1.2.7.11,1.2.7.3,1.2.7.7	ko:K00174,ko:K00186	ko00010,ko00020,ko00280,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197,R07160,R08566,R08567	RC00004,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1307	PFOR_II,POR_N
TH2_k127_5227263_22	289376.THEYE_A1886	1.807e-73	258.0	COG0618@1|root,COG0618@2|Bacteria	2|Bacteria	S	phosphoesterase RecJ domain protein	nrnA	GO:0008150,GO:0040007	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
TH2_k127_5227263_24	289376.THEYE_A1885	6.047e-38	146.0	COG0858@1|root,COG0858@2|Bacteria,3J0VV@40117|Nitrospirae	40117|Nitrospirae	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
TH2_k127_5227263_0	289376.THEYE_A1884	2.298e-306	958.0	COG0532@1|root,COG0532@2|Bacteria,3J0CC@40117|Nitrospirae	40117|Nitrospirae	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
TH2_k127_5227263_30	289376.THEYE_A1883	3.889e-19	88.0	COG0227@1|root,COG0227@2|Bacteria,3J0VJ@40117|Nitrospirae	40117|Nitrospirae	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
TH2_k127_5227263_33	443144.GM21_3498	3.406e-10	67.0	COG5512@1|root,COG5512@2|Bacteria,1N6KK@1224|Proteobacteria,42TK4@68525|delta/epsilon subdivisions,2WQQS@28221|Deltaproteobacteria,43VF7@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
TH2_k127_5227263_5	1123371.ATXH01000018_gene1401	3.526e-186	589.0	COG1219@1|root,COG1219@2|Bacteria,2GHC8@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
TH2_k127_5227263_14	1123376.AUIU01000013_gene1788	3.579e-102	342.0	COG0740@1|root,COG0740@2|Bacteria,3J0A3@40117|Nitrospirae	40117|Nitrospirae	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
TH2_k127_5227263_13	1123376.AUIU01000013_gene1787	2.644e-102	347.0	COG0544@1|root,COG0544@2|Bacteria,3J12E@40117|Nitrospirae	40117|Nitrospirae	O	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	Trigger_C,Trigger_N
TH2_k127_5227263_23	1487953.JMKF01000089_gene5388	1.108e-50	196.0	COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1H7V4@1150|Oscillatoriales	1117|Cyanobacteria	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GAF_2,GGDEF,MASE1,PAS,PAS_3,PAS_4,PAS_9
TH2_k127_5227263_11	273068.TTE2131	1.681e-120	409.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,42EQG@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
TH2_k127_5227263_18	909663.KI867149_gene3469	4.493e-93	314.0	COG1351@1|root,COG1351@2|Bacteria,1QF4I@1224|Proteobacteria,43A0P@68525|delta/epsilon subdivisions,2X9Q1@28221|Deltaproteobacteria,2MSCD@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Thymidylate synthase complementing protein	-	-	-	-	-	-	-	-	-	-	-	-	Thy1
TH2_k127_5227263_17	1123376.AUIU01000014_gene534	2.377e-98	329.0	COG0774@1|root,COG0774@2|Bacteria,3J0JG@40117|Nitrospirae	40117|Nitrospirae	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
TH2_k127_5227263_6	1123376.AUIU01000019_gene1252	3.691e-177	571.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,3J0B6@40117|Nitrospirae	40117|Nitrospirae	H	Belongs to the precorrin methyltransferase family	-	-	2.1.1.107,4.2.1.75	ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
TH2_k127_5227263_12	243231.GSU3285	1.094e-102	344.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,42M84@68525|delta/epsilon subdivisions,2WJ5V@28221|Deltaproteobacteria,43T66@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
TH2_k127_5227263_9	289376.THEYE_A0716	9.526e-137	456.0	COG0373@1|root,COG0373@2|Bacteria,3J0BD@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
TH2_k127_5227263_19	269799.Gmet_3232	4.542e-93	312.0	COG0755@1|root,COG0755@2|Bacteria,1RCCI@1224|Proteobacteria,42PVM@68525|delta/epsilon subdivisions,2WJ7I@28221|Deltaproteobacteria,43TXA@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	PFAM cytochrome c assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
TH2_k127_5227263_25	289376.THEYE_A0714	2.413e-35	149.0	COG1763@1|root,COG1763@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	-	-	-	ko:K03753,ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	-
TH2_k127_5227263_2	1125863.JAFN01000001_gene2082	8.908e-259	819.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,42MM9@68525|delta/epsilon subdivisions,2WJTT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
TH2_k127_5227263_15	289376.THEYE_A1064	7.441e-102	344.0	COG0272@1|root,COG0758@1|root,COG0272@2|Bacteria,COG0758@2|Bacteria,3J0Q8@40117|Nitrospirae	40117|Nitrospirae	L	DNA recombination-mediator protein A	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A,HHH_5
TH2_k127_5227263_3	289376.THEYE_A1063	2.772e-195	617.0	COG0137@1|root,COG0137@2|Bacteria,3J0BU@40117|Nitrospirae	40117|Nitrospirae	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
TH2_k127_5227263_28	1123376.AUIU01000018_gene74	9.526e-26	110.0	COG1504@1|root,COG1504@2|Bacteria	2|Bacteria	L	Protein of unknown function (DUF498/DUF598)	-	-	-	-	-	-	-	-	-	-	-	-	DUF498
TH2_k127_5227263_35	933262.AXAM01000027_gene2093	4.377e-07	55.0	2DSF3@1|root,33FWE@2|Bacteria,1NJN0@1224|Proteobacteria,42WZP@68525|delta/epsilon subdivisions,2WSXA@28221|Deltaproteobacteria,2MM8I@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5227263_32	913865.DOT_1087	1.189e-12	70.0	COG1122@1|root,COG1122@2|Bacteria,1V16T@1239|Firmicutes,25B0D@186801|Clostridia	186801|Clostridia	P	Abc transporter	-	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
TH2_k127_5615821_3	1121430.JMLG01000001_gene2403	1.08e-118	394.0	COG0585@1|root,COG0585@2|Bacteria,1TXVC@1239|Firmicutes,24DVS@186801|Clostridia	186801|Clostridia	J	PFAM tRNA pseudouridine synthase D TruD	-	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
TH2_k127_5615821_13	747365.Thena_1035	6.223e-20	93.0	COG0607@1|root,305HX@2|Bacteria,1VPPG@1239|Firmicutes,24V0S@186801|Clostridia	186801|Clostridia	P	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
TH2_k127_5615821_0	401526.TcarDRAFT_1997	0.0	1420.0	COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,4H20U@909932|Negativicutes	1239|Firmicutes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
TH2_k127_5615821_5	909663.KI867150_gene1144	1.287e-104	354.0	COG0845@1|root,COG0845@2|Bacteria,1MXGH@1224|Proteobacteria,42STT@68525|delta/epsilon subdivisions,2WPJI@28221|Deltaproteobacteria,2MQHI@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
TH2_k127_5615821_2	909663.KI867150_gene1143	3.849e-142	465.0	COG1538@1|root,COG1538@2|Bacteria,1PFBI@1224|Proteobacteria,43A4C@68525|delta/epsilon subdivisions,2X9UW@28221|Deltaproteobacteria,2MS4H@213462|Syntrophobacterales	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TH2_k127_5615821_6	760568.Desku_3285	8.183e-86	289.0	COG0348@1|root,COG0348@2|Bacteria,1V143@1239|Firmicutes,25BBT@186801|Clostridia,262T6@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,Fer4,Fer4_10,Fer4_4,Fer4_5,Fer4_7,Fer4_9,NAD_binding_1
TH2_k127_5615821_14	994573.T472_0214425	1.998e-14	80.0	COG0640@1|root,COG0640@2|Bacteria,1VCKP@1239|Firmicutes,24K7R@186801|Clostridia,36M8W@31979|Clostridiaceae	186801|Clostridia	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
TH2_k127_5615821_7	1282361.ABAC402_00585	2.921e-78	280.0	COG0840@1|root,COG5002@1|root,COG0840@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2TY72@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,Response_reg,SSF
TH2_k127_5615821_8	1232410.KI421412_gene383	5.866e-76	259.0	COG0778@1|root,COG0778@2|Bacteria,1RECN@1224|Proteobacteria,43DS9@68525|delta/epsilon subdivisions,2WNXD@28221|Deltaproteobacteria,43TGM@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TH2_k127_5615821_4	671143.DAMO_2073	3.394e-117	383.0	COG4249@1|root,COG4249@2|Bacteria,2NQXX@2323|unclassified Bacteria	2|Bacteria	S	Caspase domain	atmc2	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
TH2_k127_5615821_10	1291050.JAGE01000001_gene1602	3.076e-29	120.0	2C1T4@1|root,336EA@2|Bacteria,1VVT5@1239|Firmicutes,24J1U@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5615821_12	926550.CLDAP_11750	1.385e-20	99.0	COG0023@1|root,COG0023@2|Bacteria,2G9JW@200795|Chloroflexi	200795|Chloroflexi	J	Translation initiation factor SUI1	-	-	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
TH2_k127_5615821_11	56780.SYN_03004	2.689e-21	99.0	COG3064@1|root,COG3064@2|Bacteria,1R7D3@1224|Proteobacteria,42Y44@68525|delta/epsilon subdivisions,2X6IP@28221|Deltaproteobacteria,2MRQW@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5615821_1	1121448.DGI_3104	1.254e-150	498.0	COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,42MA5@68525|delta/epsilon subdivisions,2WJGZ@28221|Deltaproteobacteria,2M9Y5@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
TH2_k127_5615821_9	316274.Haur_2274	1.264e-59	209.0	COG0745@1|root,COG0745@2|Bacteria,2G6JP@200795|Chloroflexi,3773X@32061|Chloroflexia	32061|Chloroflexia	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TH2_k127_5644665_5	289376.THEYE_A0627	1.55e-103	345.0	COG0294@1|root,COG0294@2|Bacteria,3J0NS@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
TH2_k127_5644665_0	289376.THEYE_A0626	2.619e-292	906.0	COG0465@1|root,COG0465@2|Bacteria,3J0AG@40117|Nitrospirae	40117|Nitrospirae	D	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
TH2_k127_5644665_4	289376.THEYE_A1385	3.811e-104	347.0	COG0689@1|root,COG0689@2|Bacteria,3J0B8@40117|Nitrospirae	40117|Nitrospirae	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
TH2_k127_5644665_6	289376.THEYE_A1384	1.416e-95	321.0	COG0796@1|root,COG0796@2|Bacteria,3J132@40117|Nitrospirae	40117|Nitrospirae	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
TH2_k127_5644665_11	1121124.JNIX01000009_gene3078	1.829e-13	83.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,2U0K2@28211|Alphaproteobacteria,2KF5N@204458|Caulobacterales	204458|Caulobacterales	M	cell wall hydrolase	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3
TH2_k127_5644665_1	290397.Adeh_1565	2.366e-190	614.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2WIWJ@28221|Deltaproteobacteria,2YYYV@29|Myxococcales	28221|Deltaproteobacteria	P	transporter of a GTP-driven Fe(2 ) uptake system	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
TH2_k127_5644665_8	237368.SCABRO_03716	2.291e-35	139.0	COG0735@1|root,COG0735@2|Bacteria,2IZJY@203682|Planctomycetes	203682|Planctomycetes	P	Belongs to the Fur family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
TH2_k127_5644665_10	694431.DESACE_07415	8.327e-18	85.0	28ISQ@1|root,33DSE@2|Bacteria,1NJUV@1224|Proteobacteria,42XI4@68525|delta/epsilon subdivisions,2WT4N@28221|Deltaproteobacteria,2M7FT@213113|Desulfurellales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5644665_3	1123376.AUIU01000018_gene79	8.655e-116	383.0	COG1063@1|root,COG1063@2|Bacteria,3J1FG@40117|Nitrospirae	40117|Nitrospirae	E	Glucose dehydrogenase C-terminus	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
TH2_k127_5644665_2	289376.THEYE_A1024	1.056e-130	426.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
TH2_k127_5644665_7	1123376.AUIU01000014_gene603	8.364e-39	150.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,DUF4440
TH2_k127_5736370_20	903818.KI912268_gene798	1.743e-21	96.0	COG1013@1|root,COG1013@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	porB	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM0018	TPP_enzyme_C
TH2_k127_5736370_10	1123376.AUIU01000013_gene1742	1.603e-72	256.0	COG1597@1|root,COG1597@2|Bacteria,3J1CE@40117|Nitrospirae	40117|Nitrospirae	I	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
TH2_k127_5736370_16	289376.THEYE_A0810	4.639e-50	188.0	COG1424@1|root,COG1424@2|Bacteria,3J1AG@40117|Nitrospirae	40117|Nitrospirae	H	6-carboxyhexanoate--CoA ligase	-	-	6.2.1.14	ko:K01906	ko00780,ko01100,map00780,map01100	M00577	R03209	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	BioW
TH2_k127_5736370_3	335543.Sfum_1332	1.466e-157	513.0	COG4262@1|root,COG4262@2|Bacteria,1QUK8@1224|Proteobacteria,42SZH@68525|delta/epsilon subdivisions,2WPX7@28221|Deltaproteobacteria,2MQHU@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
TH2_k127_5736370_7	221288.JH992901_gene3454	5.637e-105	346.0	COG0412@1|root,COG0412@2|Bacteria,1G4HV@1117|Cyanobacteria	1117|Cyanobacteria	Q	dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DLH
TH2_k127_5736370_11	429009.Adeg_2056	3.988e-72	256.0	COG0535@1|root,COG0535@2|Bacteria,1UEHC@1239|Firmicutes,25JEE@186801|Clostridia,42GV5@68295|Thermoanaerobacterales	186801|Clostridia	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
TH2_k127_5736370_5	247490.KSU1_C0203	1.198e-141	457.0	COG0598@1|root,COG0598@2|Bacteria,2IX61@203682|Planctomycetes	203682|Planctomycetes	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
TH2_k127_5736370_19	1123376.AUIU01000011_gene1134	2.471e-29	119.0	COG2127@1|root,COG2127@2|Bacteria	2|Bacteria	T	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0050896,GO:0051087	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
TH2_k127_5736370_0	525897.Dbac_2085	2.192e-279	881.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,42M2T@68525|delta/epsilon subdivisions,2WJ2W@28221|Deltaproteobacteria,2M92I@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	ATP-dependent Clp protease ATP-binding subunit ClpA	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
TH2_k127_5736370_23	933262.AXAM01000008_gene1926	1.929e-12	73.0	2EB0T@1|root,3351P@2|Bacteria,1NJAF@1224|Proteobacteria,431ZP@68525|delta/epsilon subdivisions,2WW83@28221|Deltaproteobacteria,2MNY6@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5736370_15	879212.DespoDRAFT_02189	6.392e-54	201.0	COG0226@1|root,COG0226@2|Bacteria,1MW2Z@1224|Proteobacteria,42SWB@68525|delta/epsilon subdivisions,2WPMC@28221|Deltaproteobacteria,2MM2J@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PBP superfamily domain	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
TH2_k127_5736370_14	247490.KSU1_D0230	4.178e-57	216.0	COG2199@1|root,COG2203@1|root,COG3452@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,COG3452@2|Bacteria	2|Bacteria	T	CHASE	ytrP	-	2.7.7.65	ko:K02488,ko:K21009	ko02020,ko02025,ko04112,map02020,map02025,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	CHASE,GAF,GAF_2,GGDEF,HATPase_c,HisKA,PAS_3,PAS_8,Response_reg
TH2_k127_5736370_9	269799.Gmet_0959	5.577e-74	257.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,42S2A@68525|delta/epsilon subdivisions,2WMQ8@28221|Deltaproteobacteria,43TK2@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
TH2_k127_5736370_2	1121428.DESHY_40062___1	1.083e-178	583.0	COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,247T0@186801|Clostridia,260I6@186807|Peptococcaceae	186801|Clostridia	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
TH2_k127_5736370_4	1123376.AUIU01000012_gene1485	3.152e-142	460.0	COG0195@1|root,COG0195@2|Bacteria,3J0DF@40117|Nitrospirae	40117|Nitrospirae	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
TH2_k127_5736370_17	289376.THEYE_A0698	3.663e-43	163.0	COG0779@1|root,COG0779@2|Bacteria,3J0UD@40117|Nitrospirae	40117|Nitrospirae	J	Required for maturation of 30S ribosomal subunits	rimP	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
TH2_k127_5736370_18	767817.Desgi_1321	1.967e-36	147.0	COG1456@1|root,COG1456@2|Bacteria,1VTSK@1239|Firmicutes,24XXV@186801|Clostridia,263UF@186807|Peptococcaceae	186801|Clostridia	C	CO dehydrogenase acetyl-CoA synthase gamma subunit (Corrinoid Fe-S protein)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3786,FeS
TH2_k127_5736370_12	1449126.JQKL01000047_gene2736	1.874e-65	232.0	COG0842@1|root,COG0842@2|Bacteria,1UYEB@1239|Firmicutes,24BUQ@186801|Clostridia	186801|Clostridia	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TH2_k127_5736370_6	479434.Sthe_2137	2.207e-105	351.0	COG1131@1|root,COG1131@2|Bacteria,2G5RD@200795|Chloroflexi,27XNW@189775|Thermomicrobia	189775|Thermomicrobia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TH2_k127_5736370_1	289376.THEYE_A1146	2.722e-227	716.0	COG0747@1|root,COG0747@2|Bacteria,3J134@40117|Nitrospirae	40117|Nitrospirae	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TH2_k127_5736370_21	289376.THEYE_A1145	2.254e-20	95.0	COG1314@1|root,COG1314@2|Bacteria,3J0V0@40117|Nitrospirae	40117|Nitrospirae	U	Preprotein translocase SecG subunit	-	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
TH2_k127_5736370_8	1158318.ATXC01000001_gene583	3.656e-85	288.0	COG0149@1|root,COG0149@2|Bacteria,2G4FH@200783|Aquificae	200783|Aquificae	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
TH2_k127_5736370_13	909663.KI867149_gene3383	2.901e-61	214.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,42RNC@68525|delta/epsilon subdivisions,2WP7G@28221|Deltaproteobacteria,2MRIV@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Large-conductance mechanosensitive channel, MscL	mscL	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
TH2_k127_5736370_22	237368.SCABRO_01237	3.809e-13	69.0	2C8XG@1|root,2Z7PK@2|Bacteria,2J377@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF4197)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4197
TH2_k127_5768854_19	933262.AXAM01000008_gene1983	2.428e-31	123.0	COG0655@1|root,COG0655@2|Bacteria,1QV9P@1224|Proteobacteria,42RJT@68525|delta/epsilon subdivisions,2WNM5@28221|Deltaproteobacteria,2MJWR@213118|Desulfobacterales	28221|Deltaproteobacteria	S	NADPH-dependent FMN reductase	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red
TH2_k127_5768854_22	1304888.ATWF01000001_gene1854	0.000154	49.0	COG2608@1|root,COG2608@2|Bacteria,2GG61@200930|Deferribacteres	200930|Deferribacteres	P	Heavy-metal-associated domain	-	-	-	ko:K07213	ko04978,map04978	-	-	-	ko00000,ko00001	-	-	-	HMA
TH2_k127_5768854_10	289376.THEYE_A0686	1.817e-77	267.0	COG0846@1|root,COG0846@2|Bacteria,3J15J@40117|Nitrospirae	40117|Nitrospirae	K	Belongs to the sirtuin family. Class	-	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
TH2_k127_5768854_20	247490.KSU1_C0726	3.63e-20	93.0	COG3360@1|root,COG3360@2|Bacteria	2|Bacteria	P	Dodecin	secE2	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
TH2_k127_5768854_3	335543.Sfum_2402	7.581e-127	420.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,42MKS@68525|delta/epsilon subdivisions,2WKIH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TH2_k127_5768854_15	289376.THEYE_A0223	4.689e-55	199.0	COG0615@1|root,COG1778@1|root,COG0615@2|Bacteria,COG1778@2|Bacteria,3J0JP@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like,Hydrolase_3
TH2_k127_5768854_18	1123376.AUIU01000013_gene1797	1.608e-37	145.0	COG1051@1|root,COG1051@2|Bacteria,3J1FA@40117|Nitrospirae	40117|Nitrospirae	F	Belongs to the Nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TH2_k127_5768854_5	1123376.AUIU01000013_gene1796	1.085e-119	394.0	COG0750@1|root,COG0750@2|Bacteria,3J0GI@40117|Nitrospirae	40117|Nitrospirae	M	Peptidase family M50	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
TH2_k127_5768854_4	289376.THEYE_A0226	3.663e-124	411.0	COG0743@1|root,COG0743@2|Bacteria,3J0B0@40117|Nitrospirae	40117|Nitrospirae	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
TH2_k127_5768854_14	1123376.AUIU01000013_gene1794	7.268e-63	228.0	COG0575@1|root,COG0575@2|Bacteria,3J0QK@40117|Nitrospirae	40117|Nitrospirae	I	Cytidylyltransferase family	-	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
TH2_k127_5768854_8	1123376.AUIU01000013_gene1793	2.584e-85	288.0	COG0020@1|root,COG0020@2|Bacteria,3J0HJ@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
TH2_k127_5768854_9	289376.THEYE_A0831	4.728e-80	274.0	COG4105@1|root,COG4105@2|Bacteria,3J0UU@40117|Nitrospirae	40117|Nitrospirae	S	Tetratricopeptide repeat	-	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
TH2_k127_5768854_17	429009.Adeg_1261	7.963e-40	156.0	COG1648@1|root,COG1648@2|Bacteria,1VA2E@1239|Firmicutes,24N6M@186801|Clostridia,42GVT@68295|Thermoanaerobacterales	186801|Clostridia	H	TIGRFAM siroheme synthase	cysG	-	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M
TH2_k127_5768854_12	1499967.BAYZ01000057_gene4676	3.509e-72	256.0	COG0673@1|root,COG0673@2|Bacteria,2NNUQ@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	gnnA	-	-	ko:K09949	-	-	-	-	ko00000	-	-	iAF987.Gmet_2352	GFO_IDH_MocA
TH2_k127_5768854_1	289376.THEYE_A0828	7.905e-143	468.0	COG0399@1|root,COG0399@2|Bacteria,3J09X@40117|Nitrospirae	40117|Nitrospirae	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
TH2_k127_5768854_13	1297742.A176_02874	4.334e-67	246.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,42P35@68525|delta/epsilon subdivisions,2WJFA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
TH2_k127_5768854_0	1123371.ATXH01000003_gene1884	5.926e-160	522.0	COG1132@1|root,COG1132@2|Bacteria,2GH77@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
TH2_k127_5768854_7	671143.DAMO_1644	1.196e-88	307.0	COG1519@1|root,COG1519@2|Bacteria,2NP5A@2323|unclassified Bacteria	2|Bacteria	M	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)	kdtA	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_1,Glycos_transf_N
TH2_k127_5768854_6	316067.Geob_3294	2.097e-105	347.0	COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,42PF5@68525|delta/epsilon subdivisions,2WMD8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the WrbA family	wrbA	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_0771	FMN_red
TH2_k127_5768854_16	251229.Chro_2803	2.729e-46	171.0	COG1846@1|root,COG1846@2|Bacteria,1G6XI@1117|Cyanobacteria	1117|Cyanobacteria	K	MarR family transcriptional	-	-	-	ko:K15973	-	-	-	-	ko00000,ko03000	-	-	-	MarR
TH2_k127_5812806_8	1125863.JAFN01000001_gene2314	1.299e-24	108.0	COG2120@1|root,COG2120@2|Bacteria,1MUTM@1224|Proteobacteria,42Q20@68525|delta/epsilon subdivisions,2WP8Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	GlcNAc-PI de-N-acetylase	-	-	-	ko:K01463	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
TH2_k127_5812806_3	1125863.JAFN01000001_gene2313	6.332e-79	281.0	COG0438@1|root,COG0438@2|Bacteria,1MWVX@1224|Proteobacteria	1224|Proteobacteria	M	Glycosyl transferase group 1	mfpsA	GO:0003674,GO:0003824,GO:0005975,GO:0005984,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0034637,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0046351,GO:0071704,GO:1901576	2.4.1.14,2.4.1.246	ko:K00696,ko:K13058	ko00500,ko01100,map00500,map01100	-	R00766,R08947	RC00005,RC00028,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,S6PP,Sucrose_synth
TH2_k127_5812806_4	552811.Dehly_0334	2.093e-59	218.0	COG5653@1|root,COG5653@2|Bacteria,2G6Z0@200795|Chloroflexi,34CZI@301297|Dehalococcoidia	301297|Dehalococcoidia	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
TH2_k127_5812806_1	1125863.JAFN01000001_gene2311	4.466e-134	446.0	COG0215@1|root,COG0215@2|Bacteria	2|Bacteria	J	cysteine-tRNA ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S51
TH2_k127_5812806_5	2342.SOPEG_1702	8.856e-30	124.0	COG3597@1|root,COG3597@2|Bacteria,1RKKI@1224|Proteobacteria,1S7SS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein domain associated with	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5812806_6	351160.RCIX2417	3.404e-29	129.0	COG0584@1|root,arCOG00701@2157|Archaea,2XXRI@28890|Euryarchaeota,2NB63@224756|Methanomicrobia	224756|Methanomicrobia	C	Glycerophosphoryl diester phosphodiesterase family	glpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
TH2_k127_5812806_0	909663.KI867150_gene1369	8.873e-158	518.0	COG4262@1|root,COG4262@2|Bacteria,1QUK8@1224|Proteobacteria,42SZH@68525|delta/epsilon subdivisions,2WPX7@28221|Deltaproteobacteria,2MQHU@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
TH2_k127_5812806_2	706587.Desti_1520	2.507e-119	393.0	COG2271@1|root,COG2271@2|Bacteria,1QU9E@1224|Proteobacteria,43CQZ@68525|delta/epsilon subdivisions,2WNBR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Major Facilitator Superfamily	-	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1
TH2_k127_5824591_0	1499967.BAYZ01000074_gene2175	1.08e-135	441.0	COG4277@1|root,COG4277@2|Bacteria	2|Bacteria	-	-	MA20_15955	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	HHH_3,Radical_SAM
TH2_k127_5824591_7	1304885.AUEY01000001_gene3309	2.4e-48	182.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,42S15@68525|delta/epsilon subdivisions,2WNI1@28221|Deltaproteobacteria,2MNGZ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
TH2_k127_5824591_8	497321.C664_14604	5.827e-05	55.0	2DKZI@1|root,310D6@2|Bacteria,1QV1U@1224|Proteobacteria,2VQ0G@28216|Betaproteobacteria,2KXTS@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5824591_6	1123376.AUIU01000018_gene29	2.18e-53	194.0	COG0622@1|root,COG0622@2|Bacteria	2|Bacteria	S	retrograde transport, endosome to Golgi	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	DinB_2,Metallophos_2
TH2_k127_5824591_3	289376.THEYE_A1062	3.705e-121	398.0	COG0533@1|root,COG0533@2|Bacteria,3J0I3@40117|Nitrospirae	40117|Nitrospirae	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
TH2_k127_5824591_4	289376.THEYE_A1061	5.788e-120	395.0	COG0755@1|root,COG0755@2|Bacteria,3J0NY@40117|Nitrospirae	40117|Nitrospirae	O	Cytochrome C assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
TH2_k127_5824591_2	589865.DaAHT2_0780	3.19e-126	420.0	COG1333@1|root,COG1333@2|Bacteria,1N6XE@1224|Proteobacteria,42NBB@68525|delta/epsilon subdivisions,2WIMD@28221|Deltaproteobacteria,2MIEB@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM ResB family protein	-	-	-	ko:K07399	-	-	-	-	ko00000	-	-	-	ResB
TH2_k127_5824591_1	574087.Acear_2309	9.26e-132	436.0	COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia,3WBGE@53433|Halanaerobiales	186801|Clostridia	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	pabB	-	2.6.1.85,4.1.3.27,4.1.3.38	ko:K01657,ko:K01665,ko:K03342,ko:K13950	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716,R05553	RC00010,RC01418,RC01843,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Anth_synt_I_N,Chorismate_bind,GATase
TH2_k127_5824591_5	522306.CAP2UW1_2609	1.367e-92	315.0	COG1192@1|root,COG1357@1|root,COG1787@1|root,COG2319@1|root,COG5635@1|root,COG1192@2|Bacteria,COG1357@2|Bacteria,COG1787@2|Bacteria,COG2319@2|Bacteria,COG5635@2|Bacteria,1MWJA@1224|Proteobacteria,2VI8Q@28216|Betaproteobacteria	28216|Betaproteobacteria	V	WD40 repeats	-	-	-	-	-	-	-	-	-	-	-	-	NACHT,Pentapeptide,WD40
TH2_k127_5876443_11	443143.GM18_0106	3.602e-05	48.0	COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,42R8H@68525|delta/epsilon subdivisions,2WMWF@28221|Deltaproteobacteria,43T80@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	PEGA,Plug,TonB_dep_Rec
TH2_k127_5876443_0	1232410.KI421425_gene1538	3.069e-209	670.0	COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,42R8H@68525|delta/epsilon subdivisions,2WMWF@28221|Deltaproteobacteria,43T80@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	PEGA,Plug,TonB_dep_Rec
TH2_k127_5876443_1	398767.Glov_1653	1.095e-161	527.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,43TCZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	General secretory system II, protein E domain protein	pilB	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N,cNMP_binding
TH2_k127_5876443_5	289376.THEYE_A0692	9.532e-71	250.0	COG1526@1|root,COG1526@2|Bacteria	2|Bacteria	C	Mo-molybdopterin cofactor metabolic process	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
TH2_k127_5876443_2	247490.KSU1_C0542	1.617e-141	460.0	COG1415@1|root,COG1415@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF763)	MA20_26605	-	-	ko:K09003	-	-	-	-	ko00000	-	-	-	DUF763
TH2_k127_5876443_8	289376.THEYE_A1360	1.209e-44	169.0	COG2905@1|root,COG2905@2|Bacteria	2|Bacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
TH2_k127_5876443_6	289376.THEYE_A1361	9.644e-66	230.0	COG1392@1|root,COG1392@2|Bacteria	2|Bacteria	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
TH2_k127_5876443_4	289376.THEYE_A1362	5.096e-100	343.0	COG0306@1|root,COG0306@2|Bacteria,3J1D1@40117|Nitrospirae	40117|Nitrospirae	P	Phosphate transporter family	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
TH2_k127_5876443_9	1123376.AUIU01000015_gene463	7.132e-43	164.0	COG2885@1|root,COG2885@2|Bacteria,3J17Q@40117|Nitrospirae	40117|Nitrospirae	M	Belongs to the ompA family	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
TH2_k127_5876443_7	289376.THEYE_A2097	6.13e-56	209.0	COG1729@1|root,COG1729@2|Bacteria,3J0RE@40117|Nitrospirae	40117|Nitrospirae	S	Outer membrane lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_6
TH2_k127_5876443_3	289376.THEYE_A2096	8.724e-107	359.0	COG2896@1|root,COG2896@2|Bacteria,3J0PB@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_14,Mob_synth_C,Radical_SAM
TH2_k127_5876443_10	289376.THEYE_A2095	1.414e-38	149.0	COG0463@1|root,COG0463@2|Bacteria,3J0M5@40117|Nitrospirae	40117|Nitrospirae	M	biosynthesis glycosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TH2_k127_5894370_8	255470.cbdbA627	7.831e-41	160.0	COG0036@1|root,COG0036@2|Bacteria,2G6EU@200795|Chloroflexi,34D4E@301297|Dehalococcoidia	301297|Dehalococcoidia	G	Ribulose-phosphate 3 epimerase family	-	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
TH2_k127_5894370_3	596151.DesfrDRAFT_3924	7.467e-115	377.0	COG0176@1|root,COG0176@2|Bacteria,1MWQ8@1224|Proteobacteria,42M39@68525|delta/epsilon subdivisions,2WJEZ@28221|Deltaproteobacteria,2M90T@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
TH2_k127_5894370_0	289376.THEYE_A0954	1.364e-256	805.0	COG0021@1|root,COG0021@2|Bacteria,3J0MM@40117|Nitrospirae	40117|Nitrospirae	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
TH2_k127_5894370_7	338966.Ppro_2233	1.256e-54	198.0	2E1NK@1|root,32WZF@2|Bacteria,1QTRW@1224|Proteobacteria,42ZTM@68525|delta/epsilon subdivisions,2WV2E@28221|Deltaproteobacteria,43USI@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5894370_4	289376.THEYE_A1214	5.457e-109	361.0	COG0382@1|root,COG0382@2|Bacteria,3J0TY@40117|Nitrospirae	40117|Nitrospirae	H	UbiA prenyltransferase family	-	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
TH2_k127_5894370_1	289376.THEYE_A1213	2.502e-150	487.0	COG0402@1|root,COG0402@2|Bacteria	2|Bacteria	F	S-adenosylhomocysteine deaminase activity	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
TH2_k127_5894370_6	443143.GM18_0216	3e-72	249.0	COG0717@1|root,COG0717@2|Bacteria	2|Bacteria	F	dUTP biosynthetic process	-	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
TH2_k127_5894370_5	1496688.ER33_14330	8.712e-95	314.0	COG2085@1|root,COG2085@2|Bacteria,1G18H@1117|Cyanobacteria	1117|Cyanobacteria	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
TH2_k127_5894370_2	1267533.KB906748_gene55	4.925e-116	378.0	COG1574@1|root,COG1574@2|Bacteria,3Y2UF@57723|Acidobacteria	57723|Acidobacteria	S	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
TH2_k127_5946093_6	138119.DSY3964	4.754e-61	213.0	COG2258@1|root,COG2258@2|Bacteria,1V6DS@1239|Firmicutes,24HBA@186801|Clostridia,261U0@186807|Peptococcaceae	186801|Clostridia	S	PFAM MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	MOSC,MoCF_biosynth
TH2_k127_5946093_7	1089553.Tph_c08360	2.734e-58	207.0	COG0521@1|root,COG0521@2|Bacteria,1V3XM@1239|Firmicutes,24HG2@186801|Clostridia,42G8D@68295|Thermoanaerobacterales	186801|Clostridia	H	TIGRFAM molybdenum cofactor synthesis domain	mog	-	-	-	-	-	-	-	-	-	-	-	MOSC,MoCF_biosynth
TH2_k127_5946093_5	330214.NIDE0851	2.712e-64	233.0	COG0785@1|root,COG0785@2|Bacteria,3J0KU@40117|Nitrospirae	40117|Nitrospirae	O	Cytochrome C biogenesis protein transmembrane region	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
TH2_k127_5946093_0	1123376.AUIU01000012_gene1362	0.0	1187.0	COG0495@1|root,COG0495@2|Bacteria,3J0F8@40117|Nitrospirae	40117|Nitrospirae	J	Leucyl-tRNA synthetase, Domain 2	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
TH2_k127_5946093_8	289376.THEYE_A1210	1.521e-30	134.0	COG1466@1|root,COG1466@2|Bacteria	2|Bacteria	L	DNA-directed DNA polymerase activity	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
TH2_k127_5946093_13	1123376.AUIU01000012_gene1428	1.359e-12	72.0	COG0268@1|root,COG0268@2|Bacteria,3J0TS@40117|Nitrospirae	40117|Nitrospirae	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
TH2_k127_5946093_2	330214.NIDE4314	1.227e-117	386.0	COG1899@1|root,COG1899@2|Bacteria	2|Bacteria	O	peptidyl-lysine modification to peptidyl-hypusine	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5946093_12	224325.AF_0166	9.018e-13	70.0	COG1141@1|root,arCOG00349@2157|Archaea,2Y1VB@28890|Euryarchaeota,246J7@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S single cluster domain of Ferredoxin I	-	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13
TH2_k127_5946093_14	909663.KI867150_gene481	1.468e-11	68.0	2DE7M@1|root,2ZKVC@2|Bacteria,1P4KV@1224|Proteobacteria,432ZE@68525|delta/epsilon subdivisions,2WXP0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5946093_9	1111732.AZOD01000025_gene1721	1.748e-24	113.0	COG1430@1|root,COG1430@2|Bacteria,1MZBJ@1224|Proteobacteria,1SDVD@1236|Gammaproteobacteria,1XC4V@135614|Xanthomonadales	135614|Xanthomonadales	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
TH2_k127_5946093_1	1382306.JNIM01000001_gene549	2.142e-150	483.0	COG1023@1|root,COG1023@2|Bacteria,2G5YD@200795|Chloroflexi	200795|Chloroflexi	G	TIGRFAM 6-phosphogluconate dehydrogenase (decarboxylating)	-	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
TH2_k127_5946093_4	404589.Anae109_0599	1.026e-75	260.0	COG0363@1|root,COG0363@2|Bacteria,1R5K6@1224|Proteobacteria	1224|Proteobacteria	G	6-phosphogluconolactonase	pgl	-	2.7.1.12,3.1.1.31	ko:K00851,ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R01737,R02035	RC00002,RC00017,RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
TH2_k127_5946093_3	289376.THEYE_A1747	2.039e-114	377.0	COG0492@1|root,COG0492@2|Bacteria,3J0M0@40117|Nitrospirae	40117|Nitrospirae	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
TH2_k127_5946093_11	1123376.AUIU01000011_gene885	1.452e-17	90.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	cpeZ	-	-	ko:K05386	ko00196,ko01100,map00196,map01100	-	-	-	ko00000,ko00001,ko00194	-	-	-	DUF1822,HEAT_2
TH2_k127_6068441_3	1385512.N784_03480	6.218e-92	309.0	COG1230@1|root,COG1230@2|Bacteria,1TR92@1239|Firmicutes,4HBCQ@91061|Bacilli,2Y9NV@289201|Pontibacillus	91061|Bacilli	P	Transporter	czcD	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
TH2_k127_6068441_0	316067.Geob_3765	0.0	1328.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42M0A@68525|delta/epsilon subdivisions,2WIQY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
TH2_k127_6068441_2	316067.Geob_3766	2.639e-145	477.0	COG0845@1|root,COG0845@2|Bacteria,1PQHB@1224|Proteobacteria,42SFA@68525|delta/epsilon subdivisions,2WUV2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
TH2_k127_6068441_8	204669.Acid345_0447	1.142e-25	121.0	COG1538@1|root,COG1538@2|Bacteria,3Y4VV@57723|Acidobacteria,2JJGT@204432|Acidobacteriia	204432|Acidobacteriia	MU	Outer membrane efflux protein	-	-	-	ko:K15725	-	-	-	-	ko00000,ko02000	1.B.17.2.2	-	-	OEP
TH2_k127_6068441_6	289376.THEYE_A1535	2.63e-54	198.0	COG1496@1|root,COG1496@2|Bacteria,3J0TC@40117|Nitrospirae	40117|Nitrospirae	S	Belongs to the multicopper oxidase YfiH RL5 family	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
TH2_k127_6068441_1	289376.THEYE_A0332	3.089e-157	512.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,3J0J1@40117|Nitrospirae	40117|Nitrospirae	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	-	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
TH2_k127_6068441_4	370438.PTH_2018	5.787e-69	247.0	COG1723@1|root,COG1723@2|Bacteria,1UYJJ@1239|Firmicutes,247RU@186801|Clostridia,26009@186807|Peptococcaceae	186801|Clostridia	S	PFAM Uncharacterised ACR, YagE family COG1723	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6068441_7	1123376.AUIU01000015_gene374	3.978e-53	197.0	COG1639@1|root,COG1639@2|Bacteria,3J0NC@40117|Nitrospirae	40117|Nitrospirae	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
TH2_k127_6068441_5	1232410.KI421413_gene582	4.458e-67	239.0	COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,42QNA@68525|delta/epsilon subdivisions,2WIN0@28221|Deltaproteobacteria,43SEB@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
TH2_k127_6068441_9	1329516.JPST01000005_gene1317	5.036e-05	45.0	COG0175@1|root,COG0175@2|Bacteria,1TPR6@1239|Firmicutes,4HA1N@91061|Bacilli,27CN9@186824|Thermoactinomycetaceae	91061|Bacilli	EH	Phosphoadenosine phosphosulfate reductase family	-	-	-	ko:K19170	-	-	-	-	ko00000,ko02048	-	-	-	PAPS_reduct
TH2_k127_6297546_5	697282.Mettu_1877	5.615e-12	78.0	COG3166@1|root,COG3166@2|Bacteria,1RJTG@1224|Proteobacteria,1S6RT@1236|Gammaproteobacteria,1XE2R@135618|Methylococcales	135618|Methylococcales	NU	PFAM Fimbrial assembly	-	-	-	ko:K02461	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	PilN
TH2_k127_6297546_6	713586.KB900536_gene2476	6.821e-09	64.0	2DKUH@1|root,30CV1@2|Bacteria,1NCRM@1224|Proteobacteria,1S4X4@1236|Gammaproteobacteria,1WY93@135613|Chromatiales	135613|Chromatiales	S	General secretion pathway protein M	-	-	-	ko:K02462	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSM_b
TH2_k127_6297546_1	1223521.BBJX01000001_gene929	2.136e-37	151.0	COG1216@1|root,COG2120@1|root,COG1216@2|Bacteria,COG2120@2|Bacteria,1N72Z@1224|Proteobacteria,2WGSK@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Glycosyltransferase, group 2 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Glycos_transf_2
TH2_k127_6297546_2	1196322.A370_05543	3.074e-36	147.0	COG1682@1|root,COG1682@2|Bacteria,1TY8I@1239|Firmicutes,25B42@186801|Clostridia,36W8R@31979|Clostridiaceae	186801|Clostridia	U	Transport permease protein	-	-	-	ko:K01992,ko:K09690	ko02010,map02010	M00250,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.103	-	-	ABC2_membrane
TH2_k127_6297546_0	765914.ThisiDRAFT_2135	7.717e-93	319.0	COG1134@1|root,COG1134@2|Bacteria,1MWWC@1224|Proteobacteria,1RN2T@1236|Gammaproteobacteria,1X0NN@135613|Chromatiales	135613|Chromatiales	GM	pfam abc	-	-	-	ko:K09691	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC_tran
TH2_k127_6297546_3	765913.ThidrDRAFT_3495	5.213e-32	141.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1,Glycos_transf_2
TH2_k127_6297546_4	608538.HTH_1170	9.219e-28	128.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
TH2_k127_6319614_4	1123376.AUIU01000014_gene568	1.943e-85	304.0	COG0621@1|root,COG0621@2|Bacteria,3J112@40117|Nitrospirae	40117|Nitrospirae	J	Uncharacterized protein family UPF0004	-	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
TH2_k127_6319614_1	1304880.JAGB01000001_gene243	1.034e-120	403.0	COG0621@1|root,COG0621@2|Bacteria,1TNYN@1239|Firmicutes,2482Y@186801|Clostridia	186801|Clostridia	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
TH2_k127_6319614_0	1307759.JOMJ01000003_gene795	6.274e-158	513.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,42M0J@68525|delta/epsilon subdivisions,2WK1D@28221|Deltaproteobacteria,2M9K4@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
TH2_k127_6319614_10	589865.DaAHT2_2353	1.26e-23	102.0	COG2257@1|root,COG2257@2|Bacteria,1N7F1@1224|Proteobacteria,42VB5@68525|delta/epsilon subdivisions,2WRJD@28221|Deltaproteobacteria,2MKVP@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM FlhB HrpN YscU SpaS Family	-	-	-	ko:K04061	-	-	-	-	ko00000,ko02044	-	-	-	Bac_export_2
TH2_k127_6319614_13	1537915.JU57_12170	7.99e-09	68.0	2AN97@1|root,31D79@2|Bacteria,1QAAY@1224|Proteobacteria,42NHK@68525|delta/epsilon subdivisions,2YNFR@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Flg_hook
TH2_k127_6319614_12	211586.SO_3239	1.33e-10	72.0	COG1344@1|root,COG1344@2|Bacteria,1PJUJ@1224|Proteobacteria,1RPNR@1236|Gammaproteobacteria,2Q91X@267890|Shewanellaceae	1236|Gammaproteobacteria	N	Belongs to the bacterial flagellin family	flgL	-	-	ko:K02397	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
TH2_k127_6319614_5	933262.AXAM01000005_gene2483	1.11e-75	270.0	COG1256@1|root,COG1256@2|Bacteria,1MV2M@1224|Proteobacteria,42PBN@68525|delta/epsilon subdivisions,2WMU3@28221|Deltaproteobacteria,2MIDK@213118|Desulfobacterales	28221|Deltaproteobacteria	N	TIGRFAM flagellar hook-associated protein FlgK	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
TH2_k127_6319614_15	1288826.MSNKSG1_05251	1.894e-06	53.0	COG2747@1|root,COG2747@2|Bacteria,1NGJA@1224|Proteobacteria,1SGQ4@1236|Gammaproteobacteria,468Z3@72275|Alteromonadaceae	1236|Gammaproteobacteria	KNU	COG2747 Negative regulator of flagellin synthesis (anti-sigma28 factor)	flgM	-	-	ko:K02398	ko02020,ko02025,ko02026,ko02040,map02020,map02025,map02026,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgM
TH2_k127_6319614_9	289376.THEYE_A2057	4.77e-36	149.0	COG0739@1|root,COG0739@2|Bacteria,3J0N3@40117|Nitrospirae	40117|Nitrospirae	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TH2_k127_6319614_3	1123376.AUIU01000015_gene415	3.278e-106	359.0	COG1706@1|root,COG1706@2|Bacteria,3J0MB@40117|Nitrospirae	40117|Nitrospirae	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgI	-	-	ko:K02394	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgI
TH2_k127_6319614_7	289376.THEYE_A2059	1.829e-60	218.0	COG2063@1|root,COG2063@2|Bacteria,3J16G@40117|Nitrospirae	40117|Nitrospirae	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgH	-	-	ko:K02393	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgH
TH2_k127_6319614_11	933262.AXAM01000005_gene2496	3.1e-20	98.0	COG1261@1|root,COG1261@2|Bacteria,1QQIM@1224|Proteobacteria,42V31@68525|delta/epsilon subdivisions,2WRK7@28221|Deltaproteobacteria,2MPZR@213118|Desulfobacterales	28221|Deltaproteobacteria	N	flagella basal body P-ring formation protein FlgA	flgA	-	-	ko:K02386	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	ChapFlgA
TH2_k127_6319614_2	933262.AXAM01000005_gene2497	9.875e-107	351.0	COG4786@1|root,COG4786@2|Bacteria,1MVMA@1224|Proteobacteria,42N3R@68525|delta/epsilon subdivisions,2WJDN@28221|Deltaproteobacteria,2MIW5@213118|Desulfobacterales	28221|Deltaproteobacteria	N	flagellar basal-body rod protein FlgG	flgG	-	-	ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
TH2_k127_6319614_8	273068.TTE0172	1.075e-39	160.0	COG4786@1|root,COG4786@2|Bacteria,1TRFQ@1239|Firmicutes,24C2V@186801|Clostridia,42FI2@68295|Thermoanaerobacterales	186801|Clostridia	N	PFAM flagellar basal body rod protein	flgG	-	-	ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
TH2_k127_6319614_6	338966.Ppro_0515	2.177e-61	222.0	COG1639@1|root,COG1639@2|Bacteria,1N38F@1224|Proteobacteria,42UBF@68525|delta/epsilon subdivisions,2WQEF@28221|Deltaproteobacteria,43UGF@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Metal-dependent phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
TH2_k127_6325134_0	945713.IALB_1305	7.873e-174	558.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114	-	ko:K15876	ko00910,ko01120,map00910,map01120	M00530	R05712	RC00176	ko00000,ko00001,ko00002	-	-	-	Cytochrom_NNT,Cytochrom_c3_2
TH2_k127_6325134_1	717231.Flexsi_1286	7.168e-167	556.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,2GEJY@200930|Deferribacteres	200930|Deferribacteres	MV	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TH2_k127_6325134_5	768670.Calni_0039	1.813e-61	218.0	COG1136@1|root,COG1136@2|Bacteria,2GFQJ@200930|Deferribacteres	200930|Deferribacteres	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TH2_k127_6325134_4	880072.Desac_0177	5.185e-83	287.0	COG5621@1|root,COG5621@2|Bacteria,1MUVF@1224|Proteobacteria,42Q9D@68525|delta/epsilon subdivisions,2WK21@28221|Deltaproteobacteria,2MQ4M@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Lipocalin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9
TH2_k127_6325134_3	1385515.N791_07785	1.584e-90	322.0	29NMG@1|root,309JE@2|Bacteria,1RDNI@1224|Proteobacteria,1SMEH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6325134_7	1318628.MARLIPOL_03975	2.124e-30	130.0	28QAI@1|root,2ZCT4@2|Bacteria,1P672@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6325134_6	1318628.MARLIPOL_03970	8.538e-31	130.0	2EGRV@1|root,33AI1@2|Bacteria,1NJQM@1224|Proteobacteria,1SQI4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6325134_2	338966.Ppro_1374	6.146e-145	471.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2WIY6@28221|Deltaproteobacteria,43TW5@69541|Desulfuromonadales	28221|Deltaproteobacteria	JKL	DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlB	-	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C,R3H
TH2_k127_6325134_9	1033739.CAEU01000109_gene872	9.216e-08	58.0	2DRWY@1|root,33DG4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6325134_10	251221.35210685	4.639e-06	51.0	2DR3Q@1|root,33A1D@2|Bacteria,1GAWC@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2281
TH2_k127_6325134_8	1173263.Syn7502_03527	8.23e-12	67.0	COG2337@1|root,COG2337@2|Bacteria,1GKS2@1117|Cyanobacteria,1H3SJ@1129|Synechococcus	1117|Cyanobacteria	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
TH2_k127_6733298_9	289376.THEYE_A0727	9.174e-33	136.0	COG2188@1|root,COG2188@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
TH2_k127_6733298_4	289376.THEYE_A0707	1.312e-140	458.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K02584,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022,ko03000	-	-	-	FHA,GAF,GAF_2,HTH_8,Sigma54_activat
TH2_k127_6733298_11	909663.KI867150_gene615	2.151e-18	86.0	COG2608@1|root,COG2608@2|Bacteria	2|Bacteria	P	mercury ion transmembrane transporter activity	-	-	-	ko:K07213	ko04978,map04978	-	-	-	ko00000,ko00001	-	-	-	HMA
TH2_k127_6733298_1	1123376.AUIU01000005_gene1226	4.092e-204	656.0	COG0072@1|root,COG0072@2|Bacteria,3J0U7@40117|Nitrospirae	40117|Nitrospirae	J	B3/4 domain	-	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B5
TH2_k127_6733298_3	289376.THEYE_A1417	4.536e-142	458.0	COG0016@1|root,COG0016@2|Bacteria,3J0SW@40117|Nitrospirae	40117|Nitrospirae	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
TH2_k127_6733298_8	289376.THEYE_A1418	1.153e-42	160.0	COG0292@1|root,COG0292@2|Bacteria,3J0SF@40117|Nitrospirae	40117|Nitrospirae	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
TH2_k127_6733298_10	289376.THEYE_A1227	4.92e-21	93.0	COG0291@1|root,COG0291@2|Bacteria,3J1F4@40117|Nitrospirae	40117|Nitrospirae	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
TH2_k127_6733298_7	768706.Desor_0144	1.65e-48	178.0	COG0290@1|root,COG0290@2|Bacteria,1V1RC@1239|Firmicutes,24FUS@186801|Clostridia,260V8@186807|Peptococcaceae	186801|Clostridia	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
TH2_k127_6733298_0	289376.THEYE_A1229	1.8e-297	923.0	COG0441@1|root,COG0441@2|Bacteria,3J0F4@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
TH2_k127_6733298_6	289376.THEYE_A1230	2.657e-71	248.0	COG1136@1|root,COG1136@2|Bacteria,3J0IT@40117|Nitrospirae	40117|Nitrospirae	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
TH2_k127_6733298_2	1123376.AUIU01000014_gene724	2.317e-152	491.0	COG4591@1|root,COG4591@2|Bacteria,3J0EF@40117|Nitrospirae	40117|Nitrospirae	M	MacB-like periplasmic core domain	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
TH2_k127_6733298_5	1123376.AUIU01000014_gene725	5.18e-134	432.0	COG1190@1|root,COG1190@2|Bacteria,3J0AW@40117|Nitrospirae	40117|Nitrospirae	J	tRNA synthetases class II (D, K and N)	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
TH2_k127_6735323_6	671143.DAMO_3114	2.475e-39	149.0	COG0602@1|root,COG0602@2|Bacteria,2NPEM@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	1.97.1.4,4.3.99.3	ko:K04068,ko:K10026	ko00790,ko01100,map00790,map01100	-	R04710,R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	iAF987.Gmet_1658	Fer4_14,Radical_SAM
TH2_k127_6735323_4	289376.THEYE_A1641	4.832e-59	210.0	COG1443@1|root,COG1443@2|Bacteria	2|Bacteria	I	isopentenyl-diphosphate delta-isomerase activity	yfcD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.7.6.2,5.3.3.2	ko:K00949,ko:K01823	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R00619,R01123	RC00002,RC00017,RC00455	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_0565	NUDIX
TH2_k127_6735323_11	1123376.AUIU01000019_gene1292	2.502e-22	109.0	COG1267@1|root,COG1267@2|Bacteria,3J18R@40117|Nitrospirae	40117|Nitrospirae	I	Phosphatidylglycerophosphatase A	-	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	-	PgpA
TH2_k127_6735323_8	1047013.AQSP01000094_gene28	7.507e-36	143.0	COG1514@1|root,COG1514@2|Bacteria,2NPRT@2323|unclassified Bacteria	2|Bacteria	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
TH2_k127_6735323_2	289376.THEYE_A0533	1.382e-166	531.0	COG0468@1|root,COG0468@2|Bacteria,3J0C1@40117|Nitrospirae	40117|Nitrospirae	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
TH2_k127_6735323_14	373903.Hore_11880	3.693e-09	64.0	COG2137@1|root,COG2137@2|Bacteria,1V72V@1239|Firmicutes,24KZH@186801|Clostridia,3WAVE@53433|Halanaerobiales	186801|Clostridia	S	Modulates RecA activity	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
TH2_k127_6735323_9	1123376.AUIU01000019_gene1296	9.307e-27	115.0	COG2913@1|root,COG2913@2|Bacteria	2|Bacteria	J	Gram-negative-bacterium-type cell outer membrane assembly	osmE	GO:0006950,GO:0006970,GO:0008150,GO:0009628,GO:0050896	-	ko:K04064,ko:K06186	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	OmpA,SmpA_OmlA
TH2_k127_6735323_0	289376.THEYE_A0536	1.457e-321	1007.0	COG0013@1|root,COG0013@2|Bacteria,3J0D3@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
TH2_k127_6735323_15	272558.10175330	1.307e-06	54.0	COG3937@1|root,COG3937@2|Bacteria,1VF6E@1239|Firmicutes,4HPBK@91061|Bacilli,1ZIWR@1386|Bacillus	91061|Bacilli	S	ATP synthase, subunit b	-	-	-	-	-	-	-	-	-	-	-	-	Phasin
TH2_k127_6735323_1	1123376.AUIU01000012_gene1420	3.917e-177	574.0	COG0661@1|root,COG0661@2|Bacteria,3J0ZH@40117|Nitrospirae	40117|Nitrospirae	S	ABC1 family	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,APH
TH2_k127_6735323_3	1121920.AUAU01000004_gene896	4.825e-63	228.0	COG1575@1|root,COG2249@1|root,COG1575@2|Bacteria,COG2249@2|Bacteria,3Y5PA@57723|Acidobacteria	57723|Acidobacteria	H	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_2
TH2_k127_6735323_13	1232410.KI421421_gene3624	1.793e-20	92.0	COG0607@1|root,COG1633@1|root,COG0607@2|Bacteria,COG1633@2|Bacteria,1MZPW@1224|Proteobacteria,42NX5@68525|delta/epsilon subdivisions,2WMJ4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,Rubrerythrin
TH2_k127_6735323_5	1232410.KI421421_gene3625	2.62e-54	197.0	COG0607@1|root,COG1633@1|root,COG0607@2|Bacteria,COG1633@2|Bacteria,1MZPW@1224|Proteobacteria,42NX5@68525|delta/epsilon subdivisions,2WMJ4@28221|Deltaproteobacteria,43TND@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,Rubrerythrin
TH2_k127_6735323_10	720554.Clocl_1209	3.422e-23	102.0	COG0261@1|root,COG0261@2|Bacteria,1V9YH@1239|Firmicutes,24MRS@186801|Clostridia,3WJUU@541000|Ruminococcaceae	186801|Clostridia	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
TH2_k127_6735323_7	1173027.Mic7113_0229	1.961e-37	143.0	COG0211@1|root,COG0211@2|Bacteria,1G7RW@1117|Cyanobacteria,1HCCX@1150|Oscillatoriales	1117|Cyanobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
TH2_k127_6735323_12	1123376.AUIU01000016_gene303	2.248e-21	94.0	COG0536@1|root,COG0536@2|Bacteria,3J0E3@40117|Nitrospirae	40117|Nitrospirae	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
TH2_k127_676625_3	335543.Sfum_3289	1.853e-151	487.0	COG0730@1|root,COG0730@2|Bacteria	2|Bacteria	S	response to heat	-	-	-	-	-	-	-	-	-	-	-	-	TauE
TH2_k127_676625_2	485915.Dret_0097	2.294e-155	503.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2M7UM@213115|Desulfovibrionales	68525|delta/epsilon subdivisions	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH2_k127_676625_4	289376.THEYE_A1111	4.284e-128	428.0	COG3852@1|root,COG3852@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TH2_k127_676625_0	289376.THEYE_A1110	9.608e-162	531.0	COG3221@1|root,COG3221@2|Bacteria	2|Bacteria	P	organic phosphonate transport	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
TH2_k127_676625_7	1121405.dsmv_3469	9.236e-35	142.0	COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,42TQG@68525|delta/epsilon subdivisions,2WQG8@28221|Deltaproteobacteria,2MNQJ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM Smr protein MutS2	-	-	-	-	-	-	-	-	-	-	-	-	Smr
TH2_k127_676625_8	269799.Gmet_3052	4.069e-25	119.0	COG0265@1|root,COG0457@1|root,COG0265@2|Bacteria,COG0457@2|Bacteria,1NE6G@1224|Proteobacteria,4321S@68525|delta/epsilon subdivisions,2WWD7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
TH2_k127_676625_9	1229831.M832_08500	9.267e-10	70.0	COG0457@1|root,COG0457@2|Bacteria	1229831.M832_08500|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_676625_6	1300350.DSW25_05795	1.531e-48	180.0	COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,2U8IG@28211|Alphaproteobacteria,3ZXQR@60136|Sulfitobacter	28211|Alphaproteobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
TH2_k127_676625_5	289376.THEYE_A1109	3.968e-57	208.0	COG0491@1|root,COG0491@2|Bacteria,3J0VN@40117|Nitrospirae	40117|Nitrospirae	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TH2_k127_676625_1	289376.THEYE_A1108	1.62e-160	522.0	COG0728@1|root,COG0728@2|Bacteria,3J0CQ@40117|Nitrospirae	40117|Nitrospirae	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
TH2_k127_6769202_27	243231.GSU2959	7.257e-45	170.0	COG0053@1|root,COG0053@2|Bacteria,1ND3V@1224|Proteobacteria,431R3@68525|delta/epsilon subdivisions,2WWYS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
TH2_k127_6769202_19	1121405.dsmv_1158	2.595e-74	254.0	COG0652@1|root,COG0652@2|Bacteria,1R4KH@1224|Proteobacteria,42R08@68525|delta/epsilon subdivisions,2WWSG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K01802,ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
TH2_k127_6769202_11	335543.Sfum_0500	2.227e-106	349.0	COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,42RIR@68525|delta/epsilon subdivisions,2WP3R@28221|Deltaproteobacteria,2MSCP@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
TH2_k127_6769202_12	443144.GM21_1393	1.604e-105	352.0	COG0430@1|root,COG0430@2|Bacteria,1MX7Q@1224|Proteobacteria,42MZG@68525|delta/epsilon subdivisions,2WKZ3@28221|Deltaproteobacteria,43UBA@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	-	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
TH2_k127_6769202_10	1123376.AUIU01000015_gene353	3.884e-115	376.0	COG0413@1|root,COG0413@2|Bacteria,3J0GX@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
TH2_k127_6769202_7	349161.Dred_0731	8.565e-132	440.0	COG0608@1|root,COG0608@2|Bacteria,1TPXE@1239|Firmicutes,247NU@186801|Clostridia,25ZYA@186807|Peptococcaceae	186801|Clostridia	L	TIGRFAM single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1,Helicase_C
TH2_k127_6769202_13	443143.GM18_2290	5.486e-91	318.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,42M2H@68525|delta/epsilon subdivisions	1224|Proteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072,ko:K03074,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
TH2_k127_6769202_0	289376.THEYE_A0280	5.928e-228	717.0	COG0342@1|root,COG0342@2|Bacteria,3J09Z@40117|Nitrospirae	40117|Nitrospirae	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
TH2_k127_6769202_28	1123376.AUIU01000015_gene349	1.808e-39	150.0	COG1862@1|root,COG1862@2|Bacteria,3J0UB@40117|Nitrospirae	40117|Nitrospirae	U	Preprotein translocase subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
TH2_k127_6769202_30	497964.CfE428DRAFT_6273	1.379e-26	120.0	2CGDR@1|root,336BW@2|Bacteria,46WG2@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6769202_29	574087.Acear_0996	1.443e-28	126.0	COG0666@1|root,COG0666@2|Bacteria,1V2DE@1239|Firmicutes,24NHF@186801|Clostridia	186801|Clostridia	S	PFAM Ankyrin	-	-	-	ko:K21440	-	-	-	-	ko00000,ko04131	-	-	-	Ank_2,Ank_4,Ank_5
TH2_k127_6769202_4	335543.Sfum_3519	1.037e-155	519.0	COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42N46@68525|delta/epsilon subdivisions,2WJT4@28221|Deltaproteobacteria,2MQX0@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,Response_reg
TH2_k127_6769202_33	398767.Glov_3515	0.0003415	49.0	COG0732@1|root,COG0732@2|Bacteria,1MXVH@1224|Proteobacteria,42THZ@68525|delta/epsilon subdivisions,2WRDE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Type I restriction modification DNA specificity domain	-	-	3.1.21.3	ko:K01154	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Methylase_S
TH2_k127_6769202_31	398767.Glov_3512	5.963e-09	58.0	COG4096@1|root,COG4096@2|Bacteria,1QTS7@1224|Proteobacteria,42MXU@68525|delta/epsilon subdivisions,2WK28@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Type III restriction protein res subunit	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	EcoEI_R_C,HSDR_N,Helicase_C,ResIII
TH2_k127_6769202_8	289376.THEYE_A0577	5.71e-122	405.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TH2_k127_6769202_1	289376.THEYE_A0594	3.404e-204	653.0	COG0156@1|root,COG0156@2|Bacteria,3J0XU@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	-	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TH2_k127_6769202_25	378806.STAUR_4245	1.804e-53	200.0	COG0451@1|root,COG0451@2|Bacteria,1MX2J@1224|Proteobacteria,42TZR@68525|delta/epsilon subdivisions,2WQAW@28221|Deltaproteobacteria,2YV9A@29|Myxococcales	28221|Deltaproteobacteria	M	NmrA-like family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
TH2_k127_6769202_5	1123376.AUIU01000012_gene1446	1.153e-150	488.0	COG1030@1|root,COG1030@2|Bacteria,3J0WF@40117|Nitrospirae	40117|Nitrospirae	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
TH2_k127_6769202_15	909663.KI867150_gene1102	1.793e-87	299.0	COG2510@1|root,COG2510@2|Bacteria,1QV9N@1224|Proteobacteria,43BNU@68525|delta/epsilon subdivisions,2X704@28221|Deltaproteobacteria,2MRSY@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TH2_k127_6769202_22	986075.CathTA2_1042	1.53e-71	268.0	COG3426@1|root,COG3426@2|Bacteria,1TPKE@1239|Firmicutes,4H9QV@91061|Bacilli	91061|Bacilli	C	Belongs to the acetokinase family	buk	-	2.7.2.7	ko:K00929	ko00650,ko01100,map00650,map01100	-	R01688	RC00002,RC00043	ko00000,ko00001,ko01000	-	-	-	Acetate_kinase
TH2_k127_6769202_6	243231.GSU2486	1.437e-149	486.0	COG2403@1|root,COG2403@2|Bacteria,1MV4C@1224|Proteobacteria,42NE0@68525|delta/epsilon subdivisions,2WJ94@28221|Deltaproteobacteria,43TJC@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	cyclic 2,3-diphosphoglycerate synthetase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6769202_9	243231.GSU1222	4.683e-121	399.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42MY3@68525|delta/epsilon subdivisions,2WJEF@28221|Deltaproteobacteria,43TQX@69541|Desulfuromonadales	28221|Deltaproteobacteria	BQ	Histone deacetylase domain	-	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
TH2_k127_6769202_23	768671.ThimaDRAFT_1358	2.479e-62	232.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WWXM@135613|Chromatiales	135613|Chromatiales	T	Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S)	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
TH2_k127_6769202_14	247490.KSU1_B0116	1.035e-88	305.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6769202_32	1243664.CAVL020000028_gene102	1.197e-06	60.0	COG1404@1|root,COG3103@1|root,COG5492@1|root,COG1404@2|Bacteria,COG3103@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M43,Reprolysin_4,SH3_3,SLH,fn3
TH2_k127_6769202_18	290315.Clim_2080	9.138e-80	272.0	COG2859@1|root,COG2859@2|Bacteria,1FEXS@1090|Chlorobi	1090|Chlorobi	S	Protein of unknown function (DUF541)	-	-	-	ko:K09797	-	-	-	-	ko00000	-	-	-	SIMPL
TH2_k127_6769202_26	589865.DaAHT2_1598	9.078e-46	173.0	2C5Z2@1|root,32U5Z@2|Bacteria,1N4MT@1224|Proteobacteria,42TX0@68525|delta/epsilon subdivisions,2WQZM@28221|Deltaproteobacteria,2MKYF@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF3786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3786
TH2_k127_6769202_16	909663.KI867150_gene703	1.904e-87	302.0	COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,1NWNJ@1224|Proteobacteria,43BSA@68525|delta/epsilon subdivisions,2X860@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PAS domain	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,PAS_10,PAS_3,PAS_9
TH2_k127_6769202_3	869210.Marky_2194	1.035e-190	612.0	COG1164@1|root,COG1164@2|Bacteria,1WIBY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	TIGRFAM oligoendopeptidase, pepF M3 family	-	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
TH2_k127_6769202_2	237368.SCABRO_02649	1.102e-198	634.0	COG0778@1|root,COG0778@2|Bacteria,2J1TJ@203682|Planctomycetes	203682|Planctomycetes	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6769202_20	269799.Gmet_1239	1.335e-72	256.0	COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,42M13@68525|delta/epsilon subdivisions,2WQAC@28221|Deltaproteobacteria,43T6M@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF815)	-	-	-	ko:K06923	-	-	-	-	ko00000	-	-	-	DUF815
TH2_k127_6769202_17	56780.SYN_00515	1.256e-83	283.0	COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,42RCV@68525|delta/epsilon subdivisions,2WN35@28221|Deltaproteobacteria,2MR44@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	SNARE associated Golgi protein	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
TH2_k127_6769202_24	118163.Ple7327_1993	1.77e-59	215.0	COG1818@1|root,COG1818@2|Bacteria	2|Bacteria	S	tRNA modification	-	-	2.1.1.186	ko:K06968	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	THUMP
TH2_k127_6769202_21	338963.Pcar_1178	4.545e-72	261.0	COG1413@1|root,COG1413@2|Bacteria,1N5TU@1224|Proteobacteria,42UDF@68525|delta/epsilon subdivisions,2WQ3K@28221|Deltaproteobacteria,43TQ4@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
TH2_k127_6792309_20	909663.KI867151_gene3119	5.713e-34	136.0	COG3063@1|root,COG3063@2|Bacteria,1N4PR@1224|Proteobacteria,42TXM@68525|delta/epsilon subdivisions,2WR1F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	Type IV pilus biogenesis stability protein PilW	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_8
TH2_k127_6792309_4	289376.THEYE_A0342	2.149e-177	564.0	COG0436@1|root,COG0436@2|Bacteria,3J0EV@40117|Nitrospirae	40117|Nitrospirae	E	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TH2_k127_6792309_11	289376.THEYE_A0343	7.421e-102	339.0	COG1159@1|root,COG1159@2|Bacteria,3J0IB@40117|Nitrospirae	40117|Nitrospirae	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
TH2_k127_6792309_14	289376.THEYE_A0344	2.632e-70	241.0	COG1259@1|root,COG1259@2|Bacteria,3J0RC@40117|Nitrospirae	40117|Nitrospirae	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
TH2_k127_6792309_19	1123376.AUIU01000011_gene1041	4.094e-41	161.0	COG1381@1|root,COG1381@2|Bacteria,3J0S8@40117|Nitrospirae	40117|Nitrospirae	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
TH2_k127_6792309_2	589865.DaAHT2_2622	4.557e-194	622.0	COG0702@1|root,COG0702@2|Bacteria,1PDTN@1224|Proteobacteria,42M8X@68525|delta/epsilon subdivisions,2WJ5J@28221|Deltaproteobacteria,2MHQP@213118|Desulfobacterales	28221|Deltaproteobacteria	GM	Protein of unknown function (DUF2867)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
TH2_k127_6792309_7	1173024.KI912148_gene4873	1.996e-140	457.0	COG2334@1|root,COG2334@2|Bacteria,1G1QD@1117|Cyanobacteria,1JK42@1189|Stigonemataceae	1117|Cyanobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
TH2_k127_6792309_17	1173024.KI912148_gene4874	2.577e-57	206.0	2C0PI@1|root,301XF@2|Bacteria,1GRAZ@1117|Cyanobacteria,1JJD9@1189|Stigonemataceae	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6792309_1	289376.THEYE_A0650	6.513e-221	694.0	COG0119@1|root,COG0119@2|Bacteria,3J0F7@40117|Nitrospirae	40117|Nitrospirae	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
TH2_k127_6792309_10	289376.THEYE_A0651	5.053e-103	341.0	COG1183@1|root,COG1183@2|Bacteria,3J0KW@40117|Nitrospirae	40117|Nitrospirae	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
TH2_k127_6792309_18	589865.DaAHT2_0727	4.55e-57	205.0	COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,42QDS@68525|delta/epsilon subdivisions,2WMQ3@28221|Deltaproteobacteria,2MJQ8@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
TH2_k127_6792309_5	289376.THEYE_A0653	9.326e-172	544.0	COG0059@1|root,COG0059@2|Bacteria,3J0DW@40117|Nitrospirae	40117|Nitrospirae	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
TH2_k127_6792309_13	316067.Geob_2104	7.169e-82	283.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,42N6U@68525|delta/epsilon subdivisions,2WQ3X@28221|Deltaproteobacteria,43UMV@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	PFAM lipid A biosynthesis acyltransferase	htrB	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
TH2_k127_6792309_0	909663.KI867150_gene1564	0.0	1133.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2MQ92@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Belongs to the peptidase S16 family	-	-	3.4.21.53	ko:K01338,ko:K04076	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA_32,Lon_C,Mg_chelatase
TH2_k127_6792309_12	289376.THEYE_A0054	2.396e-100	334.0	COG4974@1|root,COG4974@2|Bacteria,3J0KV@40117|Nitrospirae	40117|Nitrospirae	D	Phage integrase, N-terminal SAM-like domain	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TH2_k127_6792309_15	330214.NIDE1591	7.79e-64	228.0	COG3359@1|root,COG3359@2|Bacteria,3J137@40117|Nitrospirae	40117|Nitrospirae	L	RNase_H superfamily	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
TH2_k127_6792309_8	316067.Geob_2354	1.195e-134	455.0	COG0845@1|root,COG0845@2|Bacteria,1MUMV@1224|Proteobacteria,42PK1@68525|delta/epsilon subdivisions,2WJ65@28221|Deltaproteobacteria,43T47@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
TH2_k127_6792309_9	247490.KSU1_C1149	7.671e-105	346.0	COG1136@1|root,COG1136@2|Bacteria,2IWZ1@203682|Planctomycetes	203682|Planctomycetes	V	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TH2_k127_6792309_3	338966.Ppro_1985	3.386e-180	571.0	COG0577@1|root,COG0577@2|Bacteria,1MWBK@1224|Proteobacteria,42PZC@68525|delta/epsilon subdivisions,2WK59@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TH2_k127_6792309_6	243231.GSU1164	4.365e-169	557.0	COG0577@1|root,COG0577@2|Bacteria,1MX7X@1224|Proteobacteria,42NT4@68525|delta/epsilon subdivisions,2WJFM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TH2_k127_6792309_16	555079.Toce_0152	8.648e-64	227.0	COG0101@1|root,COG0101@2|Bacteria,1TQUY@1239|Firmicutes,248W2@186801|Clostridia,42FMH@68295|Thermoanaerobacterales	186801|Clostridia	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
TH2_k127_6792309_21	509190.Cseg_3568	7.151e-10	59.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2TUFK@28211|Alphaproteobacteria,2KIFY@204458|Caulobacterales	204458|Caulobacterales	MU	PFAM Outer membrane efflux protein	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
TH2_k127_6821457_21	1165841.SULAR_05033	6.093e-26	110.0	COG0381@1|root,COG0381@2|Bacteria,1MWZN@1224|Proteobacteria,43B4D@68525|delta/epsilon subdivisions,2YMS6@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	G	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	-	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
TH2_k127_6821457_15	243231.GSU1255	1.103e-60	214.0	COG1999@1|root,COG1999@2|Bacteria,1N19Q@1224|Proteobacteria,42XV1@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	SCO1 SenC	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
TH2_k127_6821457_5	243231.GSU1257	3.883e-158	515.0	COG0683@1|root,COG2010@1|root,COG0683@2|Bacteria,COG2010@2|Bacteria,1R9N0@1224|Proteobacteria	1224|Proteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Peripla_BP_6
TH2_k127_6821457_14	1131269.AQVV01000013_gene1733	6.103e-61	219.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	ycbB	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TH2_k127_6821457_23	1283299.AUKG01000001_gene2259	7.846e-09	63.0	COG2456@1|root,COG2456@2|Bacteria,2HR2A@201174|Actinobacteria,4CSX5@84995|Rubrobacteria	84995|Rubrobacteria	S	Uncharacterized conserved protein (DUF2304)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2304
TH2_k127_6821457_13	1123325.JHUV01000012_gene1047	1.298e-65	241.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1,Polysacc_synt
TH2_k127_6821457_16	436114.SYO3AOP1_1005	2.182e-60	222.0	COG0438@1|root,COG0438@2|Bacteria,2G4RK@200783|Aquificae	200783|Aquificae	H	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4
TH2_k127_6821457_1	289376.THEYE_A0206	4.472e-244	760.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,3J0A1@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
TH2_k127_6821457_2	289376.THEYE_A0205	1.357e-234	734.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,3J0A2@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
TH2_k127_6821457_10	289376.THEYE_A0203	2.724e-100	334.0	COG0142@1|root,COG0142@2|Bacteria,3J0H1@40117|Nitrospirae	40117|Nitrospirae	H	Polyprenyl synthetase	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
TH2_k127_6821457_3	243231.GSU0686	9.504e-225	714.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,42M35@68525|delta/epsilon subdivisions,2WIX5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
TH2_k127_6821457_4	289376.THEYE_A1762	6.781e-169	538.0	COG0019@1|root,COG0019@2|Bacteria	2|Bacteria	E	diaminopimelate decarboxylase activity	speC	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
TH2_k127_6821457_8	289376.THEYE_A1761	1.161e-127	413.0	COG0421@1|root,COG0421@2|Bacteria	2|Bacteria	E	spermidine synthase activity	speE	GO:0003674,GO:0003824,GO:0004766,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016740,GO:0016765,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc,Spermine_synt_N,Spermine_synth
TH2_k127_6821457_9	289376.THEYE_A1760	2.629e-101	340.0	COG1420@1|root,COG1420@2|Bacteria,3J15C@40117|Nitrospirae	40117|Nitrospirae	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA
TH2_k127_6821457_18	289376.THEYE_A1759	1.191e-42	164.0	COG0576@1|root,COG0576@2|Bacteria,3J0QP@40117|Nitrospirae	40117|Nitrospirae	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
TH2_k127_6821457_0	289376.THEYE_A1758	2.51e-321	994.0	COG0443@1|root,COG0443@2|Bacteria,3J0D2@40117|Nitrospirae	40117|Nitrospirae	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
TH2_k127_6821457_6	289376.THEYE_A1757	1.728e-151	486.0	COG0484@1|root,COG0484@2|Bacteria,3J0A7@40117|Nitrospirae	40117|Nitrospirae	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
TH2_k127_6821457_17	1123376.AUIU01000019_gene1242	1.742e-44	171.0	COG1385@1|root,COG1385@2|Bacteria,3J18K@40117|Nitrospirae	40117|Nitrospirae	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
TH2_k127_6821457_19	648996.Theam_0121	1.647e-31	130.0	COG0799@1|root,COG0799@2|Bacteria,2G49D@200783|Aquificae	200783|Aquificae	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
TH2_k127_6821457_20	153721.MYP_752	8.013e-29	121.0	COG1576@1|root,COG1576@2|Bacteria,4NMFP@976|Bacteroidetes,47Q9Z@768503|Cytophagia	976|Bacteroidetes	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
TH2_k127_6821457_7	289376.THEYE_A0317	4.407e-130	429.0	COG0457@1|root,COG1066@1|root,COG5416@1|root,COG0457@2|Bacteria,COG1066@2|Bacteria,COG5416@2|Bacteria,3J1FE@40117|Nitrospirae	40117|Nitrospirae	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6821457_12	289376.THEYE_A0318	9.293e-66	234.0	COG1458@1|root,COG1458@2|Bacteria	2|Bacteria	S	PINc domain ribonuclease	-	-	-	ko:K09006	-	-	-	-	ko00000	-	-	-	DUF3368,PIN_5
TH2_k127_6821457_11	289376.THEYE_A0997	5.437e-66	231.0	COG0457@1|root,COG0457@2|Bacteria	289376.THEYE_A0997|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6821457_22	404589.Anae109_1618	1.209e-25	113.0	COG1682@1|root,COG1682@2|Bacteria,1QXTH@1224|Proteobacteria,42XN1@68525|delta/epsilon subdivisions,2WSPR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TH2_k127_6862363_2	1121403.AUCV01000035_gene3776	1.623e-53	194.0	COG2191@1|root,COG2191@2|Bacteria,1RBNI@1224|Proteobacteria,42QZP@68525|delta/epsilon subdivisions,2WMY0@28221|Deltaproteobacteria,2MJH4@213118|Desulfobacterales	28221|Deltaproteobacteria	C	FmdE, Molybdenum formylmethanofuran dehydrogenase operon	-	-	1.2.7.12	ko:K11261	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	FmdE,zf-dskA_traR
TH2_k127_6862363_4	1123376.AUIU01000011_gene1046	2.582e-12	71.0	COG1826@1|root,COG1826@2|Bacteria,3J1A4@40117|Nitrospirae	40117|Nitrospirae	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
TH2_k127_6862363_3	1565314.OA34_12830	8.888e-27	119.0	COG3381@1|root,COG3381@2|Bacteria,1NJPH@1224|Proteobacteria,43376@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Nitrate reductase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_del
TH2_k127_6862363_5	410359.Pcal_1905	6.189e-09	66.0	arCOG04198@1|root,arCOG04198@2157|Archaea	2157|Archaea	S	Ethylbenzene dehydrogenase	-	-	-	ko:K17052	-	-	-	-	ko00000,ko02000	5.A.3.8	-	-	EB_dh
TH2_k127_6862363_1	388399.SSE37_12716	7.767e-106	355.0	COG1140@1|root,COG1140@2|Bacteria,1QZP4@1224|Proteobacteria,2TYB0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	4Fe-4S dicluster domain	-	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K16965	ko00920,map00920	-	R09500	RC02555	ko00000,ko00001	-	-	-	Fer4_11
TH2_k127_6862363_0	640081.Dsui_0149	2.668e-186	619.0	COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,2VJ2F@28216|Betaproteobacteria,2KZX6@206389|Rhodocyclales	206389|Rhodocyclales	C	Molydopterin dinucleotide binding domain	-	-	-	ko:K17050	-	-	-	-	ko00000,ko02000	5.A.3.8	-	-	Molybdopterin,Molydop_binding
TH2_k127_6862363_6	1348657.M622_05000	4.683e-05	51.0	COG2010@1|root,COG2010@2|Bacteria,1PE1B@1224|Proteobacteria,2W4M1@28216|Betaproteobacteria,2KZ62@206389|Rhodocyclales	206389|Rhodocyclales	C	Ethylbenzene dehydrogenase	-	-	-	ko:K17052	-	-	-	-	ko00000,ko02000	5.A.3.8	-	-	EB_dh
TH2_k127_703649_10	644282.Deba_1078	8.022e-07	59.0	COG0745@1|root,COG3852@1|root,COG0745@2|Bacteria,COG3852@2|Bacteria,1NSIT@1224|Proteobacteria,42USH@68525|delta/epsilon subdivisions,2WQNN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HisKA,Response_reg
TH2_k127_703649_8	880072.Desac_0702	7.049e-50	189.0	COG1751@1|root,COG1751@2|Bacteria,1NERB@1224|Proteobacteria,42W3N@68525|delta/epsilon subdivisions,2WS20@28221|Deltaproteobacteria,2MS0Q@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	PFAM Pyruvate kinase, alpha beta domain	-	-	-	ko:K09126	-	-	-	-	ko00000	-	-	-	PK_C
TH2_k127_703649_6	589865.DaAHT2_1508	4.274e-75	273.0	COG0745@1|root,COG0784@1|root,COG4191@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43BKN@68525|delta/epsilon subdivisions,2X7PG@28221|Deltaproteobacteria,2MQ34@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
TH2_k127_703649_4	589865.DaAHT2_0647	4.314e-111	375.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MIB8@213118|Desulfobacterales	28221|Deltaproteobacteria	T	response regulator receiver	-	-	-	ko:K02481,ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH2_k127_703649_7	289376.THEYE_A2064	2.634e-51	192.0	COG1639@1|root,COG1639@2|Bacteria,3J0NC@40117|Nitrospirae	40117|Nitrospirae	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
TH2_k127_703649_2	1499967.BAYZ01000195_gene3087	3.484e-132	436.0	COG0265@1|root,COG0265@2|Bacteria,2NNVS@2323|unclassified Bacteria	2|Bacteria	O	smart pdz dhr glgf	htrA	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
TH2_k127_703649_0	289376.THEYE_A0896	7.613e-143	466.0	COG0037@1|root,COG0037@2|Bacteria,3J0SX@40117|Nitrospirae	40117|Nitrospirae	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS_C
TH2_k127_703649_3	555079.Toce_2222	1.101e-122	404.0	COG2768@1|root,COG2768@2|Bacteria,1TQAW@1239|Firmicutes,247IS@186801|Clostridia,42ETU@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4,Fer4_21
TH2_k127_703649_5	289376.THEYE_A1139	4.505e-109	364.0	COG1092@1|root,COG1092@2|Bacteria,3J0IV@40117|Nitrospirae	40117|Nitrospirae	J	S-adenosylmethionine-dependent methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
TH2_k127_703649_9	1123376.AUIU01000002_gene1666	1.638e-21	95.0	2DRP0@1|root,33CFM@2|Bacteria,3J1BN@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF465)	-	-	-	ko:K09794	-	-	-	-	ko00000	-	-	-	DUF465
TH2_k127_703649_1	289376.THEYE_A0862	1.153e-141	460.0	COG0129@1|root,COG0129@2|Bacteria,3J0ES@40117|Nitrospirae	40117|Nitrospirae	EG	Dehydratase family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
TH2_k127_7104802_6	289376.THEYE_A1933	1.414e-09	66.0	2E8T9@1|root,33340@2|Bacteria	2|Bacteria	S	Glycine zipper 2TM domain	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_YMGG,Rick_17kDa_Anti
TH2_k127_7104802_0	335543.Sfum_3911	0.0	1802.0	COG0458@1|root,COG0458@2|Bacteria,1NPMZ@1224|Proteobacteria,42NF3@68525|delta/epsilon subdivisions,2WM4C@28221|Deltaproteobacteria,2MQ8X@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Carbamoyl-phosphate synthetase large chain, oligomerisation	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0661	CPSase_L_D2,CPSase_L_D3,MGS
TH2_k127_7104802_2	1123242.JH636435_gene1763	3.647e-64	226.0	2DM5T@1|root,31U0Y@2|Bacteria,2J16S@203682|Planctomycetes	203682|Planctomycetes	S	Domain of unknown function (DUF4126)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4126
TH2_k127_7104802_4	1122139.KB907875_gene2575	4.815e-28	123.0	COG2261@1|root,COG2261@2|Bacteria,1N72W@1224|Proteobacteria,1S8YP@1236|Gammaproteobacteria,1XMJZ@135619|Oceanospirillales	135619|Oceanospirillales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
TH2_k127_7104802_3	159087.Daro_3855	4.332e-34	135.0	COG3753@1|root,COG3753@2|Bacteria,1N7FF@1224|Proteobacteria,2VVTK@28216|Betaproteobacteria,2KZ92@206389|Rhodocyclales	206389|Rhodocyclales	S	Bacterial protein of unknown function (DUF937)	-	-	-	-	-	-	-	-	-	-	-	-	DUF937
TH2_k127_7104802_5	1123368.AUIS01000004_gene276	1.075e-17	92.0	COG1514@1|root,COG1514@2|Bacteria	2|Bacteria	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	2_5_RNA_ligase2,CPDase
TH2_k127_7104802_1	102129.Lepto7375DRAFT_5654	4.174e-189	602.0	COG0017@1|root,COG0017@2|Bacteria,1G015@1117|Cyanobacteria,1H7PZ@1150|Oscillatoriales	1117|Cyanobacteria	J	PFAM tRNA synthetases class II (D, K and N)	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
TH2_k127_7104802_7	1385517.N800_04515	1.101e-05	56.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Laminin_G_3,Reprolysin_4,VPEP
TH2_k127_7119574_2	224324.aq_999	1.444e-168	563.0	COG0204@1|root,COG1022@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,2G3NC@200783|Aquificae	200783|Aquificae	I	PFAM AMP-dependent synthetase and ligase	fadD	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase,PP-binding
TH2_k127_7119574_21	1123376.AUIU01000011_gene948	3.955e-22	98.0	COG0695@1|root,COG0695@2|Bacteria	2|Bacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	grxC	-	1.1.98.6	ko:K03676,ko:K06191,ko:K07390,ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000,ko03029,ko03110	-	-	-	ATP-cone,Glutaredoxin,NRDD,Thioredoxin_3
TH2_k127_7119574_14	289376.THEYE_A1879	1.042e-43	161.0	COG4802@1|root,COG4802@2|Bacteria	2|Bacteria	C	ferredoxin-thioredoxin reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	FeThRed_B,Rhodanese
TH2_k127_7119574_10	331678.Cphamn1_1570	5.819e-84	284.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	yrfG	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008477,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016798,GO:0016799,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050483,GO:0050484	3.1.3.5	ko:K20881	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase
TH2_k127_7119574_15	471223.GWCH70_1081	8.259e-41	168.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli,1WEUB@129337|Geobacillus	91061|Bacilli	IQ	PFAM Short-chain dehydrogenase reductase SDR	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iYO844.BSU15910	adh_short_C2
TH2_k127_7119574_12	289376.THEYE_A1875	3.533e-59	213.0	COG0132@1|root,COG0132@2|Bacteria,3J0SI@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
TH2_k127_7119574_16	289376.THEYE_A1874	8.112e-40	153.0	COG0853@1|root,COG0853@2|Bacteria,3J0Q2@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
TH2_k127_7119574_19	1122918.KB907255_gene2385	1.919e-27	115.0	COG0721@1|root,COG0721@2|Bacteria,1VEK3@1239|Firmicutes,4HNNA@91061|Bacilli,26ZAP@186822|Paenibacillaceae	91061|Bacilli	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
TH2_k127_7119574_0	289376.THEYE_A1872	2.199e-263	829.0	COG0210@1|root,COG0210@2|Bacteria,3J0VX@40117|Nitrospirae	40117|Nitrospirae	L	UvrD-like helicase C-terminal domain	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
TH2_k127_7119574_1	671143.DAMO_1991	4.442e-227	718.0	COG0449@1|root,COG0449@2|Bacteria,2NNWC@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iAF987.Gmet_1487	GATase_6,SIS
TH2_k127_7119574_4	289376.THEYE_A1870	7.452e-141	462.0	COG1207@1|root,COG1207@2|Bacteria,3J0CG@40117|Nitrospirae	40117|Nitrospirae	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
TH2_k127_7119574_6	289376.THEYE_A1868	1.176e-117	383.0	COG0217@1|root,COG0217@2|Bacteria,3J0DM@40117|Nitrospirae	40117|Nitrospirae	K	Transcriptional regulator	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
TH2_k127_7119574_11	1123376.AUIU01000012_gene1416	4.926e-81	277.0	COG0005@1|root,COG0005@2|Bacteria,3J0HC@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
TH2_k127_7119574_20	1173025.GEI7407_0092	9.641e-24	111.0	COG1357@1|root,COG1357@2|Bacteria,1G02C@1117|Cyanobacteria,1H8G5@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Pentapeptide repeats (8 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide,Pentapeptide_4
TH2_k127_7119574_9	933262.AXAM01000005_gene2469	9.329e-88	301.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,43BSG@68525|delta/epsilon subdivisions,2WN9P@28221|Deltaproteobacteria,2MPHD@213118|Desulfobacterales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
TH2_k127_7119574_24	1265505.ATUG01000001_gene3919	1.45e-11	69.0	COG2198@1|root,COG2198@2|Bacteria,1PGXV@1224|Proteobacteria,42X5V@68525|delta/epsilon subdivisions,2WSUW@28221|Deltaproteobacteria,2MM7W@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine Phosphotransfer domain	-	-	-	-	-	-	-	-	-	-	-	-	Hpt
TH2_k127_7119574_18	1047013.AQSP01000123_gene1547	2.967e-34	139.0	COG4251@1|root,COG4251@2|Bacteria,2NS53@2323|unclassified Bacteria	2|Bacteria	T	GAF domain	letS	-	2.7.13.3	ko:K07678,ko:K07716	ko02020,ko02025,ko02026,ko04112,ko05111,map02020,map02025,map02026,map04112,map05111	M00475,M00511	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	CHASE3,DUF2222,HAMP,HATPase_c,HisKA,Hpt,PAS_4,Response_reg
TH2_k127_7119574_5	933262.AXAM01000014_gene278	3.239e-126	424.0	COG0642@1|root,COG4251@1|root,COG0642@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,43CDW@68525|delta/epsilon subdivisions,2X8IN@28221|Deltaproteobacteria,2MPP7@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,HAMP,HATPase_c,HisKA,Hpt,PAS_9,Response_reg
TH2_k127_7119574_8	243231.GSU0904	2.617e-92	311.0	COG1639@1|root,COG1639@2|Bacteria,1RAH3@1224|Proteobacteria,42PRF@68525|delta/epsilon subdivisions,2WPR9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM Metal-dependent hydrolase HDOD	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
TH2_k127_7119574_22	398767.Glov_3447	1.522e-17	86.0	COG1639@1|root,COG1639@2|Bacteria	2|Bacteria	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
TH2_k127_7119574_7	1121403.AUCV01000019_gene3283	4.925e-96	357.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MXBU@1224|Proteobacteria,42M59@68525|delta/epsilon subdivisions,2WIUK@28221|Deltaproteobacteria,2MICN@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Pyruvate phosphate dikinase, PEP	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
TH2_k127_7119574_3	909663.KI867150_gene1244	9.721e-160	516.0	COG2070@1|root,COG2070@2|Bacteria,1N52W@1224|Proteobacteria,42N6F@68525|delta/epsilon subdivisions,2WKX7@28221|Deltaproteobacteria,2MQUQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Nitronate monooxygenase	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
TH2_k127_7119574_13	591019.Shell_0193	1.504e-55	205.0	arCOG04155@1|root,arCOG04155@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_7261315_51	96561.Dole_0438	2.013e-24	107.0	COG0727@1|root,COG0727@2|Bacteria,1RG3R@1224|Proteobacteria,42RR7@68525|delta/epsilon subdivisions,2WP18@28221|Deltaproteobacteria,2MKRX@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM Uncharacterised protein family (UPF0153)	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_7261315_41	1123376.AUIU01000013_gene1754	6.518e-35	139.0	COG3688@1|root,COG3688@2|Bacteria	2|Bacteria	D	RNA-binding protein containing a PIN domain	yacP	-	-	ko:K06962	-	-	-	-	ko00000	-	-	-	EFG_C,EFG_IV,GTP_EFTU,NYN_YacP
TH2_k127_7261315_29	289376.THEYE_A0408	9.922e-65	232.0	COG0671@1|root,COG0671@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
TH2_k127_7261315_53	290397.Adeh_1087	8.229e-12	68.0	COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,42VE5@68525|delta/epsilon subdivisions,2WR8T@28221|Deltaproteobacteria,2YW4H@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
TH2_k127_7261315_35	289376.THEYE_A0406	1.591e-56	209.0	COG1561@1|root,COG1561@2|Bacteria,3J0QJ@40117|Nitrospirae	40117|Nitrospirae	S	Domain of unknown function (DUF1732)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
TH2_k127_7261315_44	1123376.AUIU01000013_gene1757	1.034e-27	114.0	COG2052@1|root,COG2052@2|Bacteria,3J1CD@40117|Nitrospirae	40117|Nitrospirae	S	Domain of unknown function (DUF370)	-	-	-	ko:K09777	-	-	-	-	ko00000	-	-	-	DUF370
TH2_k127_7261315_33	289376.THEYE_A0404	2.542e-57	207.0	COG0194@1|root,COG0194@2|Bacteria,3J0JT@40117|Nitrospirae	40117|Nitrospirae	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
TH2_k127_7261315_40	289376.THEYE_A0403	4.875e-38	145.0	COG1758@1|root,COG1758@2|Bacteria,3J0UJ@40117|Nitrospirae	40117|Nitrospirae	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
TH2_k127_7261315_14	289376.THEYE_A0402	3.397e-112	375.0	COG0452@1|root,COG0452@2|Bacteria,3J0GK@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
TH2_k127_7261315_21	748449.Halha_0530	2.928e-84	292.0	COG0006@1|root,COG0006@2|Bacteria,1TQ44@1239|Firmicutes,247SG@186801|Clostridia,3WAGD@53433|Halanaerobiales	186801|Clostridia	E	Creatinase Prolidase N-terminal domain	pepP	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
TH2_k127_7261315_23	289376.THEYE_A0400	3.115e-83	279.0	COG0231@1|root,COG0231@2|Bacteria,3J0JC@40117|Nitrospirae	40117|Nitrospirae	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
TH2_k127_7261315_37	1123376.AUIU01000013_gene1763	4.114e-45	167.0	COG0511@1|root,COG0511@2|Bacteria,3J0PI@40117|Nitrospirae	40117|Nitrospirae	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
TH2_k127_7261315_0	289376.THEYE_A0398	8.421e-207	653.0	COG0439@1|root,COG0439@2|Bacteria,3J0AJ@40117|Nitrospirae	40117|Nitrospirae	I	Biotin carboxylase C-terminal domain	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
TH2_k127_7261315_36	324602.Caur_0374	7.672e-47	176.0	COG0352@1|root,COG0352@2|Bacteria,2G6P0@200795|Chloroflexi,375RT@32061|Chloroflexia	32061|Chloroflexia	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
TH2_k127_7261315_12	671143.DAMO_1398	2.887e-120	397.0	COG0683@1|root,COG0683@2|Bacteria,2NPSN@2323|unclassified Bacteria	2|Bacteria	E	Receptor family ligand binding region	livK	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0015711,GO:0015803,GO:0015804,GO:0015818,GO:0015820,GO:0015829,GO:0015849,GO:0016597,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0070728,GO:0071702,GO:0071705	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	iECNA114_1301.ECNA114_3569,iECSF_1327.ECSF_3279,iECs_1301.ECs4309,iEcSMS35_1347.EcSMS35_3743,iG2583_1286.G2583_4163,iSFxv_1172.SFxv_3794,iSSON_1240.SSON_3698,iS_1188.S4285,iUTI89_1310.UTI89_C3965,iYL1228.KPN_03820,iZ_1308.Z4834	Peripla_BP_6
TH2_k127_7261315_54	1123376.AUIU01000014_gene718	2.899e-10	61.0	COG0230@1|root,COG0230@2|Bacteria	2|Bacteria	J	Ribosomal protein L34	rpmH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
TH2_k127_7261315_45	1173264.KI913949_gene3743	2.45e-27	112.0	COG0759@1|root,COG0759@2|Bacteria,1G90B@1117|Cyanobacteria,1HCVK@1150|Oscillatoriales	1117|Cyanobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
TH2_k127_7261315_3	289376.THEYE_A1224	1.208e-164	532.0	COG0706@1|root,COG0706@2|Bacteria,3J0GD@40117|Nitrospirae	40117|Nitrospirae	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
TH2_k127_7261315_6	289376.THEYE_A1223	9.133e-161	518.0	COG0486@1|root,COG0486@2|Bacteria,3J0JZ@40117|Nitrospirae	40117|Nitrospirae	S	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	trmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
TH2_k127_7261315_28	289376.THEYE_A1221	2.719e-67	239.0	COG0760@1|root,COG0760@2|Bacteria,3J16U@40117|Nitrospirae	40117|Nitrospirae	O	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2,SurA_N_3
TH2_k127_7261315_17	56780.SYN_00180	1.628e-95	324.0	COG0330@1|root,COG0330@2|Bacteria,1N5JY@1224|Proteobacteria,42MNX@68525|delta/epsilon subdivisions,2WXBI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
TH2_k127_7261315_16	1499967.BAYZ01000167_gene6706	4.246e-106	351.0	COG0694@1|root,COG0822@1|root,COG0694@2|Bacteria,COG0822@2|Bacteria,2NPRS@2323|unclassified Bacteria	2|Bacteria	C	NifU-like N terminal domain	nifU	-	-	ko:K04488,ko:K07126,ko:K13819	-	-	-	-	ko00000	-	-	-	Fer2_BFD,NifU,NifU_N
TH2_k127_7261315_4	439235.Dalk_2649	9.305e-164	531.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2WIR6@28221|Deltaproteobacteria,2MHW4@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	nifS-1	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
TH2_k127_7261315_22	909663.KI867150_gene2631	3.501e-84	287.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,42QXM@68525|delta/epsilon subdivisions,2WMZI@28221|Deltaproteobacteria,2MRM3@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
TH2_k127_7261315_24	690850.Desaf_1703	7.567e-80	276.0	COG1148@1|root,COG1148@2|Bacteria,1R0SK@1224|Proteobacteria,43EFN@68525|delta/epsilon subdivisions,2X89E@28221|Deltaproteobacteria,2MHDW@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
TH2_k127_7261315_15	1124780.ANNU01000023_gene3214	1.388e-108	370.0	COG1570@1|root,COG1570@2|Bacteria,4NE64@976|Bacteroidetes,47NEW@768503|Cytophagia	976|Bacteroidetes	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
TH2_k127_7261315_55	525373.HMPREF0766_10830	4.904e-06	51.0	COG1722@1|root,COG1722@2|Bacteria,4NWXT@976|Bacteroidetes,1IUJ3@117747|Sphingobacteriia	976|Bacteroidetes	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	-	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
TH2_k127_7261315_27	1123376.AUIU01000011_gene1137	1.241e-70	245.0	COG0546@1|root,COG0546@2|Bacteria	2|Bacteria	S	glycolate biosynthetic process	gph1	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD,HAD_2,Hydrolase_like
TH2_k127_7261315_39	269799.Gmet_3381	5.552e-40	158.0	COG0775@1|root,COG0775@2|Bacteria,1NDXU@1224|Proteobacteria,42TU4@68525|delta/epsilon subdivisions,2WQX3@28221|Deltaproteobacteria,43U5Q@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnB	-	3.2.2.26	ko:K11783	ko00130,ko01110,map00130,map01110	-	R08587	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
TH2_k127_7261315_49	1449126.JQKL01000028_gene2588	1.536e-24	109.0	COG1765@1|root,COG1765@2|Bacteria,1V7SN@1239|Firmicutes,24NPX@186801|Clostridia	186801|Clostridia	O	redox protein regulator of disulfide bond formation	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
TH2_k127_7261315_1	1123376.AUIU01000011_gene1120	6.14e-195	622.0	COG0029@1|root,COG0029@2|Bacteria,3J0DI@40117|Nitrospirae	40117|Nitrospirae	H	FAD binding domain	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TH2_k127_7261315_11	289376.THEYE_A1763	1.068e-130	426.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,3J0A9@40117|Nitrospirae	40117|Nitrospirae	E	Chorismate mutase type II	-	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
TH2_k127_7261315_9	289376.THEYE_A1764	4.811e-146	472.0	COG0079@1|root,COG0079@2|Bacteria,3J0XY@40117|Nitrospirae	40117|Nitrospirae	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TH2_k127_7261315_5	289376.THEYE_A1765	5.029e-163	522.0	COG2876@1|root,COG2876@2|Bacteria,3J0A5@40117|Nitrospirae	40117|Nitrospirae	E	NeuB family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
TH2_k127_7261315_26	1123376.AUIU01000011_gene854	3.555e-72	253.0	COG0287@1|root,COG0287@2|Bacteria,3J0SQ@40117|Nitrospirae	40117|Nitrospirae	C	Prephenate dehydrogenase	-	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
TH2_k127_7261315_10	289376.THEYE_A1767	1.572e-141	462.0	COG0128@1|root,COG0128@2|Bacteria,3J0BZ@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
TH2_k127_7261315_31	1123376.AUIU01000011_gene852	1.335e-59	214.0	COG0283@1|root,COG0283@2|Bacteria,3J0MY@40117|Nitrospirae	40117|Nitrospirae	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
TH2_k127_7261315_19	1123376.AUIU01000011_gene851	3.834e-90	305.0	COG0761@1|root,COG0761@2|Bacteria,3J0PP@40117|Nitrospirae	40117|Nitrospirae	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
TH2_k127_7261315_2	330214.NIDE0426	7.09e-178	572.0	COG0539@1|root,COG1185@1|root,COG0539@2|Bacteria,COG1185@2|Bacteria,3J0CA@40117|Nitrospirae	40117|Nitrospirae	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
TH2_k127_7261315_18	289376.THEYE_A1771	2.347e-92	311.0	COG0616@1|root,COG0616@2|Bacteria,3J0J0@40117|Nitrospirae	40117|Nitrospirae	OU	Peptidase family S49	-	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
TH2_k127_7261315_48	1123376.AUIU01000011_gene848	7.325e-26	110.0	COG0776@1|root,COG0776@2|Bacteria,3J19J@40117|Nitrospirae	40117|Nitrospirae	L	bacterial (prokaryotic) histone like domain	-	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
TH2_k127_7261315_46	1123376.AUIU01000013_gene1695	1.119e-26	115.0	COG0723@1|root,COG0723@2|Bacteria,3J0TT@40117|Nitrospirae	40117|Nitrospirae	C	Rieske [2Fe-2S] domain	-	-	1.10.9.1	ko:K02636,ko:K03886	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00151,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Rieske
TH2_k127_7261315_25	1123376.AUIU01000013_gene1696	1.945e-78	276.0	COG1290@1|root,COG1290@2|Bacteria,3J0Q6@40117|Nitrospirae	40117|Nitrospirae	C	Cytochrome b/b6/petB	-	-	-	ko:K03887	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrome_B
TH2_k127_7261315_8	1123376.AUIU01000015_gene429	1.208e-149	492.0	COG0277@1|root,COG0277@2|Bacteria,3J0ZS@40117|Nitrospirae	40117|Nitrospirae	C	FAD linked oxidases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
TH2_k127_7261315_34	289376.THEYE_A1398	7.593e-57	205.0	COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,3J0PD@40117|Nitrospirae	40117|Nitrospirae	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
TH2_k127_7261315_7	289376.THEYE_A0690	3.915e-154	495.0	COG0113@1|root,COG0113@2|Bacteria,3J0DV@40117|Nitrospirae	40117|Nitrospirae	H	Delta-aminolevulinic acid dehydratase	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
TH2_k127_7261315_47	289376.THEYE_A0691	1.13e-26	114.0	COG0316@1|root,COG0316@2|Bacteria,3J0TZ@40117|Nitrospirae	40117|Nitrospirae	S	Belongs to the HesB IscA family	-	-	-	ko:K15724	-	-	-	-	ko00000	-	-	-	Fe-S_biosyn
TH2_k127_7261315_13	886379.AEWI01000005_gene957	5.59e-120	399.0	COG0372@1|root,COG0372@2|Bacteria,4NFXK@976|Bacteroidetes,2FPF3@200643|Bacteroidia,3XJB7@558415|Marinilabiliaceae	976|Bacteroidetes	C	Citrate synthase, C-terminal domain	prpC	-	2.3.3.1,2.3.3.5	ko:K01647,ko:K01659	ko00020,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351,R00931	RC00004,RC00067,RC00406,RC02827	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
TH2_k127_7261315_20	1142394.PSMK_08370	5.49e-89	309.0	COG1077@1|root,COG1077@2|Bacteria	2|Bacteria	D	Cell shape determining protein MreB Mrl	mreB2	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
TH2_k127_7261315_38	795359.TOPB45_0428	5.149e-45	177.0	COG0860@1|root,COG1388@1|root,COG0860@2|Bacteria,COG1388@2|Bacteria,2GH8K@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	Ami_3	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,LysM
TH2_k127_7261315_50	314345.SPV1_09378	2.002e-24	104.0	COG3369@1|root,COG3369@2|Bacteria,1N6QZ@1224|Proteobacteria	1224|Proteobacteria	S	Zinc finger cdgsh-type domain protein	-	-	-	-	-	-	-	-	-	-	-	-	zf-CDGSH
TH2_k127_7261315_42	243231.GSU0383	1.075e-29	123.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,42MCS@68525|delta/epsilon subdivisions,2WQGI@28221|Deltaproteobacteria,43V4U@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
TH2_k127_7261315_43	1121920.AUAU01000031_gene1407	7.666e-28	115.0	COG1942@1|root,COG1942@2|Bacteria	2|Bacteria	S	isomerase activity	dmpI	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
TH2_k127_7261315_56	1122994.AUFR01000046_gene469	0.0003834	46.0	COG1704@1|root,COG1704@2|Bacteria,2GPS4@201174|Actinobacteria,4DR1W@85009|Propionibacteriales	201174|Actinobacteria	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
TH2_k127_7261315_30	644282.Deba_0416	2.264e-62	229.0	COG0642@1|root,COG1639@1|root,COG1639@2|Bacteria,COG2205@2|Bacteria,1PGJ2@1224|Proteobacteria,431J2@68525|delta/epsilon subdivisions,2WW71@28221|Deltaproteobacteria	2|Bacteria	T	COGs COG1639 signal transduction protein	-	-	-	-	-	-	-	-	-	-	-	-	HDOD,HisKA,Response_reg
TH2_k127_7261315_32	316067.Geob_2071	1.836e-59	209.0	COG0655@1|root,COG0655@2|Bacteria,1RD5X@1224|Proteobacteria,42T3S@68525|delta/epsilon subdivisions,2WN9W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
TH2_k127_7346255_8	1499967.BAYZ01000167_gene6732	2.693e-19	101.0	2DRYY@1|root,33DRD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_7346255_7	1167006.UWK_02683	1.688e-24	109.0	COG3417@1|root,COG3417@2|Bacteria	2|Bacteria	M	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)	lpoB	GO:0000270,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0019899,GO:0030203,GO:0030234,GO:0030312,GO:0030313,GO:0031241,GO:0031975,GO:0034645,GO:0042546,GO:0043085,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044093,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044462,GO:0044464,GO:0050790,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	-	ko:K07337,ko:K21008	ko02025,map02025	-	-	-	ko00000,ko00001	-	-	-	LpoB
TH2_k127_7346255_0	1167006.UWK_02684	7.553e-192	618.0	COG0457@1|root,COG1225@1|root,COG1462@1|root,COG0457@2|Bacteria,COG1225@2|Bacteria,COG1462@2|Bacteria,1NK5T@1224|Proteobacteria	1224|Proteobacteria	M	Curli production assembly/transport component CsgG	-	-	-	-	-	-	-	-	-	-	-	-	CsgG
TH2_k127_7346255_2	1167006.UWK_02685	3.461e-89	314.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2MHTH@213118|Desulfobacterales	28221|Deltaproteobacteria	KLT	PFAM Protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CHASE2,Pkinase,cNMP_binding
TH2_k127_7346255_6	1167006.UWK_02686	2.352e-35	147.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	Trypsin_2
TH2_k127_7346255_4	335543.Sfum_2540	3.651e-70	244.0	COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,42QUA@68525|delta/epsilon subdivisions,2WP2A@28221|Deltaproteobacteria,2MRZW@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	PFAM Protein phosphatase 2C	-	-	3.1.3.16	ko:K01090,ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
TH2_k127_7346255_5	1265505.ATUG01000001_gene4611	1.55e-64	231.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	-	-	-	-	-	-	-	-	-	-	FHA
TH2_k127_7346255_1	335543.Sfum_2541	5.827e-156	509.0	COG1716@1|root,COG2203@1|root,COG5000@1|root,COG1716@2|Bacteria,COG2203@2|Bacteria,COG5000@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.7.13.3,3.1.4.17,4.6.1.1	ko:K01120,ko:K01768,ko:K02486,ko:K11356,ko:K11894,ko:K11913	ko00230,ko02020,ko02025,ko03070,ko04113,ko04213,map00230,map02020,map02025,map03070,map04113,map04213	M00695	R00089,R00191,R00434,R01234	RC00295,RC00296	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02044	3.A.23.1	-	-	FHA,GAF,HATPase_c,HisKA,PAS,PAS_9,Response_reg,Yop-YscD_cpl
TH2_k127_7346255_3	1449346.JQMO01000003_gene4814	1.309e-85	303.0	COG2890@1|root,COG2890@2|Bacteria,2GJPP@201174|Actinobacteria,2M0DS@2063|Kitasatospora	201174|Actinobacteria	J	Ribosomal protein L11 methyltransferase (PrmA)	rsmC	-	-	-	-	-	-	-	-	-	-	-	MTS
TH2_k127_7350608_6	289376.THEYE_A2090	1.285e-56	203.0	COG1694@1|root,COG3956@2|Bacteria,3J0Q7@40117|Nitrospirae	40117|Nitrospirae	S	MazG nucleotide pyrophosphohydrolase domain	-	-	-	ko:K02499	-	-	-	-	ko00000,ko03036	-	-	-	MazG
TH2_k127_7350608_9	1123376.AUIU01000015_gene438	2.308e-33	130.0	COG1278@1|root,COG1278@2|Bacteria,3J0QZ@40117|Nitrospirae	40117|Nitrospirae	K	'Cold-shock' DNA-binding domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TH2_k127_7350608_2	1121428.DESHY_160142___1	4.223e-93	316.0	COG0320@1|root,COG0320@2|Bacteria,1TQM4@1239|Firmicutes,2495Q@186801|Clostridia,2619Z@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,LIAS_N,Radical_SAM
TH2_k127_7350608_0	1123376.AUIU01000015_gene435	1.566e-179	572.0	COG0460@1|root,COG0460@2|Bacteria,3J0G1@40117|Nitrospirae	40117|Nitrospirae	E	Homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
TH2_k127_7350608_1	237368.SCABRO_00962	1.24e-109	361.0	COG0476@1|root,COG0476@2|Bacteria,2IY5K@203682|Planctomycetes	203682|Planctomycetes	H	ThiF family	-	-	-	-	-	-	-	-	-	-	-	-	ThiF
TH2_k127_7350608_10	269799.Gmet_1569	2.221e-27	116.0	COG1310@1|root,COG1310@2|Bacteria,1N3TI@1224|Proteobacteria,42TY4@68525|delta/epsilon subdivisions,2WW9Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	SMART Mov34 MPN PAD-1 family protein	-	-	3.13.1.6	ko:K21140	ko04122,map04122	-	R11524	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB
TH2_k127_7350608_5	289376.THEYE_A0189	4.836e-67	235.0	COG0500@1|root,COG2226@2|Bacteria,3J0S6@40117|Nitrospirae	40117|Nitrospirae	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
TH2_k127_7350608_7	1123376.AUIU01000012_gene1443	6.12e-48	183.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,3J0J4@40117|Nitrospirae	40117|Nitrospirae	M	Lysin motif	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
TH2_k127_7350608_4	335543.Sfum_2526	1.45e-81	282.0	COG1163@1|root,COG1163@2|Bacteria,1RFPD@1224|Proteobacteria,42ZF3@68525|delta/epsilon subdivisions,2WUZY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	TGS domain	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,TGS
TH2_k127_7350608_11	706587.Desti_1459	1.376e-10	68.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42N46@68525|delta/epsilon subdivisions,2WJT4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
TH2_k127_7350608_3	1121472.AQWN01000003_gene1583	3.246e-85	295.0	COG2195@1|root,COG2195@2|Bacteria,1TP3A@1239|Firmicutes,248JJ@186801|Clostridia,26079@186807|Peptococcaceae	186801|Clostridia	E	TIGRFAM peptidase T-like protein	-	-	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TH2_k127_7350608_8	909663.KI867150_gene1773	3.047e-45	164.0	COG1403@1|root,COG1403@2|Bacteria,1RGZQ@1224|Proteobacteria,42UXJ@68525|delta/epsilon subdivisions,2WQ0I@28221|Deltaproteobacteria,2MS3A@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	HNH
TH2_k127_7862470_8	266117.Rxyl_1117	3.906e-16	80.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4CQ2R@84995|Rubrobacteria	84995|Rubrobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K09695	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC_tran
TH2_k127_7862470_0	289376.THEYE_A1240	5.419e-164	524.0	COG0505@1|root,COG0505@2|Bacteria,3J0CS@40117|Nitrospirae	40117|Nitrospirae	F	Carbamoyl-phosphate synthase small chain, CPSase domain	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
TH2_k127_7862470_1	330214.NIDE2540	2.432e-160	520.0	COG0044@1|root,COG0044@2|Bacteria,3J0D7@40117|Nitrospirae	40117|Nitrospirae	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
TH2_k127_7862470_2	289376.THEYE_A1238	5.436e-126	410.0	COG0540@1|root,COG0540@2|Bacteria,3J0FJ@40117|Nitrospirae	40117|Nitrospirae	F	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
TH2_k127_7862470_5	330214.NIDE2538	7.283e-67	233.0	COG2065@1|root,COG2065@2|Bacteria,3J0JX@40117|Nitrospirae	40117|Nitrospirae	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
TH2_k127_7862470_7	316067.Geob_1193	1.257e-30	130.0	COG4765@1|root,COG4765@2|Bacteria,1N5MU@1224|Proteobacteria,42TQ6@68525|delta/epsilon subdivisions,2WR2C@28221|Deltaproteobacteria,43VB1@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2155)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2155
TH2_k127_7862470_3	768671.ThimaDRAFT_3386	9.772e-83	290.0	COG0265@1|root,COG3016@1|root,COG0265@2|Bacteria,COG3016@2|Bacteria,1MX1I@1224|Proteobacteria,1RPWZ@1236|Gammaproteobacteria,1WX9T@135613|Chromatiales	135613|Chromatiales	O	smart pdz dhr glgf	-	-	-	-	-	-	-	-	-	-	-	-	Cofac_haem_bdg,PDZ_2
TH2_k127_7862470_4	1123325.JHUV01000011_gene1554	5.37e-80	274.0	COG2041@1|root,COG2041@2|Bacteria	2|Bacteria	V	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	sorA	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Mo-co_dimer,Oxidored_molyb
TH2_k127_786542_33	706587.Desti_3149	6.691e-38	150.0	COG0613@1|root,COG0613@2|Bacteria,1RF04@1224|Proteobacteria,42RR4@68525|delta/epsilon subdivisions,2WNC8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM PHP domain	-	-	-	-	-	-	-	-	-	-	-	-	PHP,PHP_C
TH2_k127_786542_35	194439.CT1237	2.62e-22	104.0	COG4194@1|root,COG4194@2|Bacteria,1FF6D@1090|Chlorobi	1090|Chlorobi	S	Protein of unknown function (DUF1648)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1648
TH2_k127_786542_20	1089553.Tph_c26520	1.07e-69	250.0	COG0134@1|root,COG0134@2|Bacteria,1TR94@1239|Firmicutes,249ZY@186801|Clostridia,42EQ2@68295|Thermoanaerobacterales	186801|Clostridia	E	Belongs to the TrpC family	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
TH2_k127_786542_26	555079.Toce_2117	6.801e-52	189.0	COG0245@1|root,COG0245@2|Bacteria,1V3P0@1239|Firmicutes,24HCM@186801|Clostridia,42FTZ@68295|Thermoanaerobacterales	186801|Clostridia	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
TH2_k127_786542_27	1120973.AQXL01000112_gene1049	1.649e-51	191.0	COG1211@1|root,COG1211@2|Bacteria,1V3M7@1239|Firmicutes,4HH2N@91061|Bacilli,278HX@186823|Alicyclobacillaceae	91061|Bacilli	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
TH2_k127_786542_15	234267.Acid_1863	1.035e-97	330.0	COG4956@1|root,COG4956@2|Bacteria,3Y2RT@57723|Acidobacteria	57723|Acidobacteria	S	Large family of predicted nucleotide-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
TH2_k127_786542_4	1123376.AUIU01000011_gene922	3.335e-172	552.0	COG0265@1|root,COG0265@2|Bacteria,3J0X9@40117|Nitrospirae	40117|Nitrospirae	M	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
TH2_k127_786542_3	289376.THEYE_A0071	6.556e-219	702.0	COG3276@1|root,COG3276@2|Bacteria,3J1FB@40117|Nitrospirae	40117|Nitrospirae	J	Elongation factor SelB, winged helix	-	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
TH2_k127_786542_18	289376.THEYE_A0070	4.423e-81	274.0	COG0118@1|root,COG0118@2|Bacteria,3J0K7@40117|Nitrospirae	40117|Nitrospirae	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
TH2_k127_786542_39	357804.Ping_1904	7.346e-07	55.0	COG3462@1|root,COG3462@2|Bacteria,1NGXC@1224|Proteobacteria,1SGF3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Short C-terminal domain	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
TH2_k127_786542_30	289376.THEYE_A0584	2.788e-43	169.0	COG0357@1|root,COG0357@2|Bacteria,3J18F@40117|Nitrospirae	40117|Nitrospirae	J	Specifically methylates the N7 position of a guanine in 16S rRNA	gidB	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
TH2_k127_786542_2	289376.THEYE_A0585	5.878e-288	896.0	COG0445@1|root,COG0445@2|Bacteria,3J0E9@40117|Nitrospirae	40117|Nitrospirae	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
TH2_k127_786542_31	289376.THEYE_A0587	1.18e-42	169.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
TH2_k127_786542_6	289376.THEYE_A0588	1.544e-151	484.0	COG0463@1|root,COG0463@2|Bacteria,3J13C@40117|Nitrospirae	40117|Nitrospirae	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TH2_k127_786542_5	289376.THEYE_A0589	8.888e-164	541.0	COG0671@1|root,COG1807@1|root,COG0671@2|Bacteria,COG1807@2|Bacteria,3J155@40117|Nitrospirae	40117|Nitrospirae	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2,PMT_2
TH2_k127_786542_17	330214.NIDE3218	1.086e-87	302.0	COG0388@1|root,COG0388@2|Bacteria,3J11H@40117|Nitrospirae	40117|Nitrospirae	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
TH2_k127_786542_34	153721.MYP_1558	9.716e-28	121.0	COG0300@1|root,COG0300@2|Bacteria,4NN9E@976|Bacteroidetes,47PJ9@768503|Cytophagia	976|Bacteroidetes	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TH2_k127_786542_9	289376.THEYE_A0539	1.986e-132	431.0	COG0232@1|root,COG0232@2|Bacteria	2|Bacteria	F	Belongs to the dGTPase family. Type 2 subfamily	dgt	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
TH2_k127_786542_7	289376.THEYE_A0538	1.539e-143	471.0	COG1921@1|root,COG1921@2|Bacteria	2|Bacteria	E	L-seryl-tRNASec selenium transferase activity	selA	GO:0003674,GO:0003824,GO:0004125,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0019752,GO:0019842,GO:0030170,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0090304,GO:0097056,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	iECP_1309.ECP_3693,iSbBS512_1146.SbBS512_E4006	Se-cys_synth_N,SelA
TH2_k127_786542_40	247490.KSU1_B0116	2.219e-06	50.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_786542_13	289376.THEYE_A0135	4.014e-108	356.0	COG0727@1|root,COG0727@2|Bacteria	2|Bacteria	S	metal cluster binding	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
TH2_k127_786542_38	1121930.AQXG01000004_gene2986	1.099e-11	70.0	2CH0Y@1|root,32S8V@2|Bacteria,4P9I5@976|Bacteroidetes,1IZHK@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_786542_36	1189612.A33Q_3001	1.861e-15	77.0	2EGPU@1|root,33AFZ@2|Bacteria,4NXYH@976|Bacteroidetes,47S90@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_786542_32	118161.KB235922_gene1040	4.964e-39	162.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_786542_1	932678.THERU_04050	5.118e-289	898.0	COG2192@1|root,COG2192@2|Bacteria	2|Bacteria	O	nodulation	nolO	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
TH2_k127_786542_12	289376.THEYE_A0134	2.845e-114	381.0	COG0820@1|root,COG0820@2|Bacteria,3J0CH@40117|Nitrospirae	40117|Nitrospirae	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
TH2_k127_786542_11	269799.Gmet_0034	1.602e-121	401.0	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,42N75@68525|delta/epsilon subdivisions,2WKJY@28221|Deltaproteobacteria,43SDV@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
TH2_k127_786542_29	269799.Gmet_0836	1.375e-43	166.0	COG2068@1|root,COG2068@2|Bacteria,1RAAE@1224|Proteobacteria,42QNZ@68525|delta/epsilon subdivisions,2WMYX@28221|Deltaproteobacteria,43V5W@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	HD,NTP_transf_3
TH2_k127_786542_21	243231.GSU0202	7.356e-68	242.0	COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,42QUY@68525|delta/epsilon subdivisions,2WMVP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	NTP_transf_3,XdhC_C,XdhC_CoxI
TH2_k127_786542_0	269799.Gmet_0837	3.067e-320	995.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,42NU9@68525|delta/epsilon subdivisions,2WKXG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2,Fer2,Fer2_2
TH2_k127_786542_23	909663.KI867150_gene22	1.106e-66	231.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,42SQU@68525|delta/epsilon subdivisions,2WPRP@28221|Deltaproteobacteria,2MRV2@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	[2Fe-2S] binding domain	-	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
TH2_k127_786542_14	316067.Geob_3043	1.221e-105	362.0	COG2239@1|root,COG2239@2|Bacteria,1RFCV@1224|Proteobacteria,42S1B@68525|delta/epsilon subdivisions,2WP0D@28221|Deltaproteobacteria,43VZG@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	MgtE intracellular N domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,MgtE_N,PRC
TH2_k127_786542_10	289376.THEYE_A1501	7.568e-122	403.0	COG0182@1|root,COG0182@2|Bacteria,3J0G0@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
TH2_k127_786542_16	1123376.AUIU01000015_gene476	1.141e-94	321.0	COG0142@1|root,COG0142@2|Bacteria,3J0H0@40117|Nitrospirae	40117|Nitrospirae	H	Polyprenyl synthetase	-	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
TH2_k127_786542_24	1123376.AUIU01000012_gene1328	1.253e-62	221.0	COG2078@1|root,COG2078@2|Bacteria	2|Bacteria	S	ferrous iron binding	amrA	-	-	ko:K06990,ko:K09141	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,LigB
TH2_k127_786542_25	1042156.CXIVA_05810	2.588e-55	198.0	COG0315@1|root,COG0315@2|Bacteria,1V3J4@1239|Firmicutes,24H9F@186801|Clostridia,36J0W@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
TH2_k127_786542_8	880072.Desac_1129	2.601e-136	447.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42M88@68525|delta/epsilon subdivisions,2WIZI@28221|Deltaproteobacteria,2MRE2@213462|Syntrophobacterales	28221|Deltaproteobacteria	KT	PFAM Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_9,Sigma54_activat
TH2_k127_786542_28	289376.THEYE_A1167	8.346e-48	178.0	COG0607@1|root,COG2897@1|root,COG0607@2|Bacteria,COG2897@2|Bacteria	2|Bacteria	P	thiosulfate sulfurtransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TH2_k127_786542_19	289376.THEYE_A1167	1.962e-74	258.0	COG0607@1|root,COG2897@1|root,COG0607@2|Bacteria,COG2897@2|Bacteria	2|Bacteria	P	thiosulfate sulfurtransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TH2_k127_786542_22	443144.GM21_3582	2.248e-67	239.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,42PHP@68525|delta/epsilon subdivisions,2WIXN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Involved in the TonB-independent uptake of proteins	tolB	GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
TH2_k127_7946536_10	247490.KSU1_D0598	2.603e-27	118.0	COG2199@1|root,COG3706@2|Bacteria,2J108@203682|Planctomycetes	203682|Planctomycetes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
TH2_k127_7946536_12	56780.SYN_00958	1.177e-17	93.0	2DQ2P@1|root,334I3@2|Bacteria	2|Bacteria	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
TH2_k127_7946536_7	552811.Dehly_0138	7.389e-69	248.0	COG4191@1|root,COG4191@2|Bacteria,2G6UY@200795|Chloroflexi,34D87@301297|Dehalococcoidia	301297|Dehalococcoidia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9
TH2_k127_7946536_4	289376.THEYE_A0813	4.842e-91	312.0	COG1291@1|root,COG1291@2|Bacteria	2|Bacteria	N	archaeal or bacterial-type flagellum-dependent cell motility	motA	GO:0006935,GO:0008150,GO:0009605,GO:0040011,GO:0042221,GO:0042330,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0052116,GO:0052126,GO:0052127,GO:0052143,GO:0052192,GO:0052195,GO:0052216,GO:0052243	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
TH2_k127_7946536_6	56780.SYN_00960	3.082e-72	258.0	COG1360@1|root,COG1360@2|Bacteria,1MW1Y@1224|Proteobacteria,42S6Q@68525|delta/epsilon subdivisions,2WNX0@28221|Deltaproteobacteria,2MRWK@213462|Syntrophobacterales	28221|Deltaproteobacteria	N	Membrane MotB of proton-channel complex MotA/MotB	-	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
TH2_k127_7946536_1	667014.Thein_1806	1.068e-148	484.0	COG2204@1|root,COG2204@2|Bacteria,2GHIR@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH2_k127_7946536_8	1125863.JAFN01000001_gene692	1.255e-62	229.0	COG5000@1|root,COG5000@2|Bacteria,1QUG9@1224|Proteobacteria,43BPN@68525|delta/epsilon subdivisions,2WPAZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS
TH2_k127_7946536_2	330214.NIDE2284	8.285e-136	444.0	COG2204@1|root,COG2204@2|Bacteria,3J0FP@40117|Nitrospirae	40117|Nitrospirae	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K10943	ko02020,ko05111,map02020,map05111	M00515	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH2_k127_7946536_11	1502852.FG94_02585	4.605e-18	89.0	COG1815@1|root,COG1815@2|Bacteria,1MZ8P@1224|Proteobacteria,2VUJ4@28216|Betaproteobacteria,474IW@75682|Oxalobacteraceae	28216|Betaproteobacteria	N	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body	flgB	-	-	ko:K02387	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod
TH2_k127_7946536_9	909663.KI867150_gene1911	2.137e-38	149.0	COG1558@1|root,COG1558@2|Bacteria,1RHI3@1224|Proteobacteria,42TPI@68525|delta/epsilon subdivisions,2WP1C@28221|Deltaproteobacteria,2MS5M@213462|Syntrophobacterales	28221|Deltaproteobacteria	N	Flagella basal body rod protein	flgC	-	-	ko:K02388	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
TH2_k127_7946536_15	289376.THEYE_A0266	1.708e-10	67.0	COG1677@1|root,COG1677@2|Bacteria,3J0UT@40117|Nitrospirae	40117|Nitrospirae	N	Flagellar hook-basal body complex protein FliE	fliE	-	-	ko:K02408	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliE
TH2_k127_7946536_3	1123376.AUIU01000013_gene1852	5.934e-123	412.0	COG1766@1|root,COG1766@2|Bacteria,3J0A6@40117|Nitrospirae	40117|Nitrospirae	N	The M ring may be actively involved in energy transduction	fliF	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
TH2_k127_7946536_5	289376.THEYE_A0268	1.521e-80	279.0	COG1536@1|root,COG1536@2|Bacteria,3J0GZ@40117|Nitrospirae	40117|Nitrospirae	N	FliG middle domain	fliG	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
TH2_k127_7946536_13	439235.Dalk_0669	1.213e-14	81.0	COG1317@1|root,COG1317@2|Bacteria,1NJAJ@1224|Proteobacteria,42P5I@68525|delta/epsilon subdivisions,2WSGD@28221|Deltaproteobacteria,2MQ0H@213118|Desulfobacterales	28221|Deltaproteobacteria	N	Flagellar assembly protein FliH	fliH	-	-	ko:K02411	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliH
TH2_k127_7946536_0	635013.TherJR_1539	2.434e-157	507.0	COG1157@1|root,COG1157@2|Bacteria,1TP0R@1239|Firmicutes,25E6B@186801|Clostridia,26126@186807|Peptococcaceae	186801|Clostridia	NU	TIGRFAM ATPase, FliI YscN family	fliI	-	3.6.3.14	ko:K02412,ko:K03224	ko02040,ko03070,map02040,map03070	M00332,M00542,M00660	-	-	ko00000,ko00001,ko00002,ko01000,ko02035,ko02044	3.A.6.1,3.A.6.2,3.A.6.3	-	-	ATP-synt_ab,ATP-synt_ab_N
TH2_k127_7946536_14	289376.THEYE_A0272	1.554e-14	81.0	COG3334@1|root,COG3334@2|Bacteria	2|Bacteria	S	PFAM MgtE intracellular	ylxF	-	-	ko:K02383	-	-	-	-	ko00000,ko02035	-	-	-	MgtE_N
TH2_k127_7950672_13	1173263.Syn7502_03499	2.002e-12	70.0	COG1413@1|root,COG1413@2|Bacteria,1G2ZR@1117|Cyanobacteria	1117|Cyanobacteria	CT	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS,Vitellogenin_N
TH2_k127_7950672_3	429009.Adeg_0355	1.104e-131	429.0	COG1180@1|root,COG1180@2|Bacteria,1V170@1239|Firmicutes,24E3W@186801|Clostridia,42HNZ@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S single cluster domain	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
TH2_k127_7950672_11	404589.Anae109_1226	1.142e-15	80.0	COG3197@1|root,COG3197@2|Bacteria,1Q3MJ@1224|Proteobacteria,42XI0@68525|delta/epsilon subdivisions,2WT8I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	TIGRFAM cytochrome oxidase maturation protein, cbb3-type	-	-	-	-	-	-	-	-	-	-	-	-	FixS
TH2_k127_7950672_0	290397.Adeh_1177	1.624e-256	814.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WMJD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
TH2_k127_7950672_7	517417.Cpar_1666	4.425e-41	161.0	COG2836@1|root,COG2836@2|Bacteria,1FEFV@1090|Chlorobi	1090|Chlorobi	S	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K09792	-	-	-	-	ko00000	-	-	-	DsbD_2
TH2_k127_7950672_10	1121405.dsmv_1428	7.426e-17	91.0	COG5456@1|root,COG5456@2|Bacteria,1R398@1224|Proteobacteria,4338A@68525|delta/epsilon subdivisions,2WYHW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	FixH	-	-	-	-	-	-	-	-	-	-	-	-	FixH
TH2_k127_7950672_15	414684.RC1_1275	2.926e-07	61.0	COG5456@1|root,COG5456@2|Bacteria,1Q27E@1224|Proteobacteria,2V9N2@28211|Alphaproteobacteria,2JU3B@204441|Rhodospirillales	204441|Rhodospirillales	P	FixH	-	-	-	-	-	-	-	-	-	-	-	-	FixH
TH2_k127_7950672_4	404589.Anae109_1222	5.771e-104	351.0	COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,42M8Q@68525|delta/epsilon subdivisions,2WNZJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	ccoG	-	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
TH2_k127_7950672_12	118005.AWNK01000012_gene23	1.168e-15	80.0	2ESEE@1|root,33JZ4@2|Bacteria	2|Bacteria	S	N-terminal domain of cytochrome oxidase-cbb3, FixP	-	-	-	-	-	-	-	-	-	-	-	-	FixP_N
TH2_k127_7950672_5	768670.Calni_0819	2.767e-101	337.0	COG2010@1|root,COG2993@1|root,COG2010@2|Bacteria,COG2993@2|Bacteria,2GF4M@200930|Deferribacteres	200930|Deferribacteres	C	PFAM cytochrome C oxidase mono-heme subunit FixO	-	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,FixO
TH2_k127_7950672_1	404589.Anae109_1218	3.885e-253	786.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,42M5M@68525|delta/epsilon subdivisions,2WM27@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the heme-copper respiratory oxidase family	-	-	1.9.3.1	ko:K00404,ko:K15862	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1,FixO
TH2_k127_7950672_8	589865.DaAHT2_0174	6.173e-33	133.0	COG1959@1|root,COG1959@2|Bacteria,1MZ1C@1224|Proteobacteria,42SPF@68525|delta/epsilon subdivisions,2WPVC@28221|Deltaproteobacteria,2MM91@213118|Desulfobacterales	28221|Deltaproteobacteria	K	TIGRFAM transcriptional regulator, Rrf2 family	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
TH2_k127_7950672_9	1040989.AWZU01000032_gene3433	1.857e-19	90.0	COG3360@1|root,COG3360@2|Bacteria,1PE74@1224|Proteobacteria,2UCH8@28211|Alphaproteobacteria,3K04J@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
TH2_k127_7950672_2	335543.Sfum_2948	2.101e-218	686.0	COG2848@1|root,COG2848@2|Bacteria,1NAFG@1224|Proteobacteria,42NH7@68525|delta/epsilon subdivisions,2WJJM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	UPF0210 protein	-	-	-	ko:K09157	-	-	-	-	ko00000	-	-	-	DUF711
TH2_k127_7950672_6	335543.Sfum_2949	1.271e-75	258.0	COG2716@1|root,COG2716@2|Bacteria,1RB6J@1224|Proteobacteria,42RTX@68525|delta/epsilon subdivisions,2WPGC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM amino acid-binding ACT domain protein	-	-	-	ko:K03567	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	ACT_6
TH2_k127_7985378_11	1340493.JNIF01000004_gene748	0.0003668	48.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
TH2_k127_7985378_5	1202768.JROF01000002_gene92	7.145e-70	265.0	COG2203@1|root,arCOG03567@1|root,arCOG02369@2157|Archaea,arCOG03567@2157|Archaea,2XUM1@28890|Euryarchaeota,23UN4@183963|Halobacteria	183963|Halobacteria	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,MEDS
TH2_k127_7985378_1	316067.Geob_0942	7.018e-130	434.0	COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria	1224|Proteobacteria	G	glucose sorbosone	gdhB	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	CBM_2,GSDH
TH2_k127_7985378_2	867903.ThesuDRAFT_01077	2.864e-109	362.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,3WCYH@538999|Clostridiales incertae sedis	186801|Clostridia	EP	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
TH2_k127_7985378_3	521098.Aaci_2262	1.971e-94	320.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,4H9YB@91061|Bacilli	91061|Bacilli	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TH2_k127_7985378_9	1121441.AUCX01000009_gene2478	2.931e-28	119.0	2CH86@1|root,2ZY5B@2|Bacteria,1Q4TW@1224|Proteobacteria,435W3@68525|delta/epsilon subdivisions,2X0BZ@28221|Deltaproteobacteria,2MBRY@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF2628)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2628
TH2_k127_7985378_6	338966.Ppro_1590	2.724e-68	240.0	COG0045@1|root,COG0045@2|Bacteria,1REBV@1224|Proteobacteria,42S1F@68525|delta/epsilon subdivisions,2WNW1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5
TH2_k127_7985378_4	234267.Acid_1970	1.394e-88	305.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,DUF2048,Peptidase_S9
TH2_k127_7985378_7	1283300.ATXB01000001_gene2100	1.357e-51	190.0	COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,1RPZ3@1236|Gammaproteobacteria,1XFMD@135618|Methylococcales	135618|Methylococcales	U	MarC family integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	MarC
TH2_k127_7985378_0	1121403.AUCV01000001_gene873	2.456e-158	504.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42MSQ@68525|delta/epsilon subdivisions,2WISJ@28221|Deltaproteobacteria,2MPW4@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK-1	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
TH2_k127_7986411_10	243231.GSU0351	4.473e-77	265.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42P7Z@68525|delta/epsilon subdivisions,2WK06@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TH2_k127_7986411_0	289376.THEYE_A1342	7.74e-215	678.0	COG1418@1|root,COG1418@2|Bacteria,3J0C8@40117|Nitrospirae	40117|Nitrospirae	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
TH2_k127_7986411_2	289376.THEYE_A1341	5.581e-109	358.0	COG1692@1|root,COG1692@2|Bacteria,3J0JW@40117|Nitrospirae	40117|Nitrospirae	S	YmdB-like protein	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
TH2_k127_7986411_13	1123376.AUIU01000014_gene620	5.016e-52	186.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
TH2_k127_7986411_1	706587.Desti_0850	1.013e-127	444.0	COG0745@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIU5@28221|Deltaproteobacteria,2MQZQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TH2_k127_7986411_12	1396418.BATQ01000012_gene4461	1.055e-62	221.0	COG1247@1|root,COG1247@2|Bacteria	2|Bacteria	M	phosphinothricin N-acetyltransferase activity	yncA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_4
TH2_k127_7986411_3	671143.DAMO_1397	3.695e-108	359.0	COG0559@1|root,COG0559@2|Bacteria,2NP7Z@2323|unclassified Bacteria	2|Bacteria	E	Branched-chain amino acid transport system / permease component	livH	GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015190,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098713,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	iJN746.PP_4866,iSFV_1184.SFV_3460,iSF_1195.SF3475,iSFxv_1172.SFxv_3791,iS_1188.S4288	BPD_transp_2
TH2_k127_7986411_5	671143.DAMO_1396	1.108e-93	321.0	COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,2NNYG@2323|unclassified Bacteria	2|Bacteria	E	Branched-chain amino acid ATP-binding cassette transporter	livM	GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	iPC815.YPO3806,iSDY_1059.SDY_3605	ABC_tran,BCA_ABC_TP_C,BPD_transp_2,DUF3382
TH2_k127_7986411_7	1121438.JNJA01000001_gene2222	7.452e-83	282.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,42M5G@68525|delta/epsilon subdivisions,2X5IV@28221|Deltaproteobacteria,2MGRN@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	pfam abc	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TH2_k127_7986411_8	1121451.DESAM_20534	1.356e-82	280.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42M9C@68525|delta/epsilon subdivisions,2WJ75@28221|Deltaproteobacteria,2M8GA@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM ABC transporter related	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
TH2_k127_7986411_15	1123376.AUIU01000012_gene1352	2.153e-29	119.0	COG1254@1|root,COG1254@2|Bacteria	2|Bacteria	C	Belongs to the acylphosphatase family	acyP	GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
TH2_k127_7986411_4	289376.THEYE_A0809	4.752e-96	323.0	COG0502@1|root,COG0502@2|Bacteria,3J0I9@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
TH2_k127_7986411_9	290397.Adeh_1998	1.054e-79	289.0	COG4585@1|root,COG4585@2|Bacteria,1N0JE@1224|Proteobacteria,42UG3@68525|delta/epsilon subdivisions,2WQFT@28221|Deltaproteobacteria,2Z1DF@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA_3
TH2_k127_7986411_14	335543.Sfum_2574	5.294e-42	169.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,42NCJ@68525|delta/epsilon subdivisions,2WM7Z@28221|Deltaproteobacteria,2MQJH@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	ko:K13283	-	-	-	-	ko00000,ko02000	2.A.4.7.1	-	-	Cation_efflux,ZT_dimer
TH2_k127_7986411_11	1379698.RBG1_1C00001G0669	1.967e-63	231.0	COG3064@1|root,COG3064@2|Bacteria	2|Bacteria	M	translation initiation factor activity	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	Peptidase_M56
TH2_k127_7986411_6	404589.Anae109_0837	7.652e-90	301.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,42QRC@68525|delta/epsilon subdivisions,2WMP7@28221|Deltaproteobacteria,2YUHQ@29|Myxococcales	28221|Deltaproteobacteria	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
TH2_k127_801253_20	1121438.JNJA01000014_gene520	4.656e-28	118.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42P5K@68525|delta/epsilon subdivisions,2WIKI@28221|Deltaproteobacteria,2M8G7@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH2_k127_801253_15	316067.Geob_1719	2.077e-51	198.0	COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,42MC9@68525|delta/epsilon subdivisions,2WIYS@28221|Deltaproteobacteria,43T97@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Nitrogen fixation master sensor histidine kinase, PAS domain-containing	gnfL	-	2.7.13.3	ko:K02668,ko:K07708,ko:K07709	ko02020,map02020	M00497,M00499,M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8
TH2_k127_801253_16	289376.THEYE_A0791	3.214e-51	189.0	COG1057@1|root,COG1057@2|Bacteria,3J0T3@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
TH2_k127_801253_1	1123376.AUIU01000011_gene1023	5.789e-183	581.0	COG0014@1|root,COG0014@2|Bacteria,3J0ET@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TH2_k127_801253_21	1123376.AUIU01000011_gene1022	3.058e-25	106.0	COG1141@1|root,COG1141@2|Bacteria	2|Bacteria	C	electron transfer activity	-	-	-	ko:K05337,ko:K17247	-	-	-	-	ko00000	-	-	-	Fer4_13,Ferric_reduct
TH2_k127_801253_12	289376.THEYE_A0788	7.606e-62	218.0	COG0494@1|root,COG0494@2|Bacteria,3J0TN@40117|Nitrospirae	40117|Nitrospirae	L	NUDIX domain	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
TH2_k127_801253_18	373903.Hore_12750	6.407e-41	156.0	COG0537@1|root,COG0537@2|Bacteria,1V9ZJ@1239|Firmicutes,24JCW@186801|Clostridia,3WBSP@53433|Halanaerobiales	186801|Clostridia	FG	Histidine triad (HIT) protein	hinT	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
TH2_k127_801253_17	1123376.AUIU01000011_gene1019	1.824e-46	170.0	COG0139@1|root,COG0139@2|Bacteria,3J0T7@40117|Nitrospirae	40117|Nitrospirae	E	Phosphoribosyl-AMP cyclohydrolase	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH,PRA-PH
TH2_k127_801253_9	243231.GSU1185	4.457e-74	253.0	COG1839@1|root,COG1839@2|Bacteria,1RBCB@1224|Proteobacteria,42S44@68525|delta/epsilon subdivisions,2WMAS@28221|Deltaproteobacteria,43UGI@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
TH2_k127_801253_3	289376.THEYE_A1378	3.29e-171	563.0	COG5000@1|root,COG5000@2|Bacteria,3J0B7@40117|Nitrospirae	40117|Nitrospirae	T	GHKL domain	-	-	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS
TH2_k127_801253_2	289376.THEYE_A1377	7.467e-176	562.0	COG2204@1|root,COG2204@2|Bacteria,3J0C2@40117|Nitrospirae	40117|Nitrospirae	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH2_k127_801253_8	289376.THEYE_A1376	1.29e-122	407.0	COG1160@1|root,COG1160@2|Bacteria,3J0G3@40117|Nitrospirae	40117|Nitrospirae	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	engA	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
TH2_k127_801253_5	289376.THEYE_A1375	5.359e-138	447.0	COG0451@1|root,COG0451@2|Bacteria,3J0ZC@40117|Nitrospirae	40117|Nitrospirae	M	Male sterility protein	-	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
TH2_k127_801253_14	289376.THEYE_A1374	7.826e-61	213.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TH2_k127_801253_13	926569.ANT_30960	7.962e-62	226.0	COG1951@1|root,COG1951@2|Bacteria,2G6YI@200795|Chloroflexi	200795|Chloroflexi	C	Fumarate hydratase (Fumerase)	-	-	4.2.1.2	ko:K01676,ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
TH2_k127_801253_4	1118235.CAJH01000060_gene3380	8.017e-169	544.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,1RNUS@1236|Gammaproteobacteria,1X3ED@135614|Xanthomonadales	135614|Xanthomonadales	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
TH2_k127_801253_10	1123376.AUIU01000015_gene481	1.414e-70	254.0	COG5000@1|root,COG5000@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.7.13.3	ko:K07709,ko:K07710	ko02020,map02020	M00499,M00500	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF3365,HAMP,HATPase_c,HisKA,PAS,PAS_9
TH2_k127_801253_11	316067.Geob_1882	2.969e-69	242.0	2CAZH@1|root,2Z7RU@2|Bacteria,1RBDC@1224|Proteobacteria,42SC7@68525|delta/epsilon subdivisions,2WP8S@28221|Deltaproteobacteria,43SJW@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	TIGRFAM succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family	frdC	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
TH2_k127_801253_0	443144.GM21_0913	0.0	1058.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,42M81@68525|delta/epsilon subdivisions,2WIJ5@28221|Deltaproteobacteria,43TAF@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit	frdA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TH2_k127_801253_7	338963.Pcar_0444	1.117e-124	406.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,42M2J@68525|delta/epsilon subdivisions,2WK9D@28221|Deltaproteobacteria,43S0Z@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	frdB	-	1.3.5.1,1.3.5.4	ko:K00240,ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2395	Fer2_3,Fer4_7,Fer4_8
TH2_k127_801253_6	289377.HL41_04680	2.794e-129	427.0	COG2204@1|root,COG2204@2|Bacteria,2GH04@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH2_k127_8078914_4	933262.AXAM01000042_gene1817	1.426e-49	191.0	COG1555@1|root,COG3156@1|root,COG1555@2|Bacteria,COG3156@2|Bacteria,1PQMW@1224|Proteobacteria,42T9B@68525|delta/epsilon subdivisions,2WPYT@28221|Deltaproteobacteria,2MKAN@213118|Desulfobacterales	28221|Deltaproteobacteria	LU	Type II secretion system (T2SS), protein K	-	-	-	ko:K02460	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSK
TH2_k127_8078914_7	177437.HRM2_30160	3.163e-12	75.0	COG4966@1|root,COG4966@2|Bacteria,1QEE6@1224|Proteobacteria,433H9@68525|delta/epsilon subdivisions,2WY1D@28221|Deltaproteobacteria,2MPCI@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	pilus assembly protein PilW	-	-	-	ko:K02459	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	-
TH2_k127_8078914_11	177437.HRM2_30170	9.389e-07	61.0	COG4967@1|root,COG4967@2|Bacteria,1Q4E0@1224|Proteobacteria,42Y2U@68525|delta/epsilon subdivisions,2WTGP@28221|Deltaproteobacteria,2MM8B@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	type IV pilus modification protein PilV	-	-	-	ko:K02458	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
TH2_k127_8078914_9	1500890.JQNL01000001_gene1566	6.083e-08	61.0	COG4970@1|root,COG4970@2|Bacteria,1NBWI@1224|Proteobacteria,1S5MN@1236|Gammaproteobacteria,1X78Z@135614|Xanthomonadales	135614|Xanthomonadales	NU	COG4970 Tfp pilus assembly protein FimT	-	-	-	ko:K02457	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GspH,N_methyl
TH2_k127_8078914_2	933262.AXAM01000042_gene1810	2.394e-107	361.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42MH9@68525|delta/epsilon subdivisions,2WJE0@28221|Deltaproteobacteria,2MIYV@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	Type II secretion system (T2SS), protein F	-	-	-	ko:K02455	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSF
TH2_k127_8078914_1	671143.DAMO_2489	1.249e-178	572.0	COG2804@1|root,COG2804@2|Bacteria,2NNNI@2323|unclassified Bacteria	2|Bacteria	NU	Type II secretion system (T2SS), protein E, N-terminal domain	xpsE	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
TH2_k127_8078914_10	994573.T472_0219610	1.261e-07	65.0	COG0589@1|root,COG0589@2|Bacteria,1VEJR@1239|Firmicutes,24QQ6@186801|Clostridia	186801|Clostridia	T	universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TH2_k127_8078914_8	370438.PTH_1606	2.248e-08	56.0	COG0695@1|root,COG0695@2|Bacteria	2|Bacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	-	-	-	ko:K03676	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
TH2_k127_8078914_6	289376.THEYE_A1926	2.186e-29	123.0	COG3118@1|root,COG3118@2|Bacteria,3J0P6@40117|Nitrospirae	40117|Nitrospirae	O	Thioredoxin-like domain	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
TH2_k127_8078914_5	289376.THEYE_A1997	1.319e-30	129.0	COG1546@1|root,COG1546@2|Bacteria,3J1AS@40117|Nitrospirae	40117|Nitrospirae	S	Competence-damaged protein	-	-	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA
TH2_k127_8078914_0	289376.THEYE_A2000	3.21e-303	943.0	COG0272@1|root,COG0272@2|Bacteria,3J0W8@40117|Nitrospirae	40117|Nitrospirae	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
TH2_k127_8078914_3	933262.AXAM01000008_gene1983	2.225e-65	226.0	COG0655@1|root,COG0655@2|Bacteria,1QV9P@1224|Proteobacteria,42RJT@68525|delta/epsilon subdivisions,2WNM5@28221|Deltaproteobacteria,2MJWR@213118|Desulfobacterales	28221|Deltaproteobacteria	S	NADPH-dependent FMN reductase	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red
TH2_k127_8106844_1	243231.GSU1454	3.397e-201	638.0	COG1215@1|root,COG1215@2|Bacteria,1MXG7@1224|Proteobacteria,42MRD@68525|delta/epsilon subdivisions,2X5MW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
TH2_k127_8106844_10	400682.PAC_15723568	8.325e-05	55.0	KOG3060@1|root,KOG3060@2759|Eukaryota,39G9G@33154|Opisthokonta,3BFA8@33208|Metazoa	33208|Metazoa	S	ER membrane protein complex subunit	EMC2	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006457,GO:0008150,GO:0009987,GO:0012505,GO:0016020,GO:0016021,GO:0030176,GO:0031224,GO:0031227,GO:0031984,GO:0032991,GO:0034975,GO:0042175,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0072546,GO:0098796,GO:0098827	-	-	-	-	-	-	-	-	-	-	TPR_19,TPR_8
TH2_k127_8106844_6	1123376.AUIU01000011_gene828	7.934e-70	246.0	COG0566@1|root,COG0566@2|Bacteria,3J0RH@40117|Nitrospirae	40117|Nitrospirae	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
TH2_k127_8106844_2	289376.THEYE_A1975	3.062e-200	646.0	COG0215@1|root,COG0215@2|Bacteria,3J0CM@40117|Nitrospirae	40117|Nitrospirae	J	DALR_2	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
TH2_k127_8106844_3	289376.THEYE_A1974	3.482e-177	575.0	COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria	2|Bacteria	C	2Fe-2S iron-sulfur cluster binding domain	nqrF	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
TH2_k127_8106844_8	443143.GM18_2399	1.462e-58	207.0	2AVTU@1|root,31MME@2|Bacteria,1NQ7V@1224|Proteobacteria,42XCN@68525|delta/epsilon subdivisions,2WTFJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8106844_5	316067.Geob_2394	1.568e-76	262.0	COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,42R18@68525|delta/epsilon subdivisions,2WN0H@28221|Deltaproteobacteria,43UH3@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	3.1.11.2,4.2.99.18	ko:K01142,ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,Exo_endo_phos,HhH-GPD
TH2_k127_8106844_0	289376.THEYE_A0629	0.0	1700.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,3J0TJ@40117|Nitrospirae	40117|Nitrospirae	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
TH2_k127_8106844_4	289376.THEYE_A0982	2.423e-112	370.0	COG2084@1|root,COG2084@2|Bacteria,3J0R5@40117|Nitrospirae	40117|Nitrospirae	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
TH2_k127_8106844_9	483219.LILAB_14955	4.054e-36	145.0	COG1451@1|root,COG1451@2|Bacteria,1P1X1@1224|Proteobacteria,4314C@68525|delta/epsilon subdivisions,2WX53@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	nucleotide metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8139475_3	443143.GM18_2049	7.839e-72	249.0	COG1801@1|root,COG1801@2|Bacteria,1N4QE@1224|Proteobacteria,42PDW@68525|delta/epsilon subdivisions,2WK6H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
TH2_k127_8139475_6	344747.PM8797T_29668	1.295e-43	170.0	COG1624@1|root,COG1624@2|Bacteria,2IYC1@203682|Planctomycetes	203682|Planctomycetes	H	Diadenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	DisA_N
TH2_k127_8139475_4	1123376.AUIU01000011_gene971	6.203e-50	187.0	COG0727@1|root,COG0727@2|Bacteria	2|Bacteria	S	metal cluster binding	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
TH2_k127_8139475_5	1304885.AUEY01000016_gene3046	6.766e-48	191.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,42MMF@68525|delta/epsilon subdivisions,2WJ1F@28221|Deltaproteobacteria,2MHQX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_8
TH2_k127_8139475_2	871963.Desdi_1171	1.035e-77	268.0	COG1606@1|root,COG1606@2|Bacteria,1TPB2@1239|Firmicutes,2485J@186801|Clostridia,260CU@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM TIGR00268 family protein	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	ATP_bind_3,Asn_synthase,NAD_synthase
TH2_k127_8139475_1	398767.Glov_0469	3.779e-181	581.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	ribonuclease Rne Rng family	cafA	-	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
TH2_k127_8139475_0	1123376.AUIU01000011_gene968	1.588e-244	781.0	COG1032@1|root,COG5011@1|root,COG1032@2|Bacteria,COG5011@2|Bacteria	2|Bacteria	C	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344,Radical_SAM
TH2_k127_8146336_6	1047013.AQSP01000140_gene2511	5.618e-64	231.0	COG2202@1|root,COG2203@1|root,COG3920@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3920@2|Bacteria,2NPS5@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase	pdtaS	-	2.7.13.3	ko:K00936,ko:K02030	-	M00236,M00839	-	-	ko00000,ko00002,ko01000,ko01001,ko02000,ko02022	3.A.1.3	-	-	HATPase_c,HATPase_c_2,H_kinase_N,HisKA_2,PAS_3,PAS_9
TH2_k127_8146336_1	1163617.SCD_n02443	4.543e-195	637.0	COG3850@1|root,COG5001@1|root,COG3850@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,EAL,GGDEF,PAS,PAS_3
TH2_k127_8146336_2	1163617.SCD_n02443	4.558e-147	486.0	COG3850@1|root,COG5001@1|root,COG3850@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,EAL,GGDEF,PAS,PAS_3
TH2_k127_8146336_4	1121918.ARWE01000001_gene3297	1.958e-73	259.0	COG0644@1|root,COG0644@2|Bacteria,1R4JF@1224|Proteobacteria	1224|Proteobacteria	C	COG0644 Dehydrogenases (flavoproteins)	-	-	-	-	-	-	-	-	-	-	-	-	HI0933_like,NAD_binding_8
TH2_k127_8146336_9	289376.THEYE_A1609	1.226e-43	164.0	COG0589@1|root,COG0589@2|Bacteria,3J1E9@40117|Nitrospirae	40117|Nitrospirae	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TH2_k127_8146336_10	584708.Apau_1577	2.567e-34	143.0	COG1521@1|root,COG1521@2|Bacteria,3TAGH@508458|Synergistetes	508458|Synergistetes	H	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
TH2_k127_8146336_8	1123376.AUIU01000019_gene1236	6.328e-55	207.0	COG0340@1|root,COG0340@2|Bacteria,3J0U2@40117|Nitrospirae	40117|Nitrospirae	H	Biotin/lipoate A/B protein ligase family	-	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB
TH2_k127_8146336_3	289376.THEYE_A1612	1.908e-86	291.0	COG2220@1|root,COG2220@2|Bacteria	2|Bacteria	S	N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
TH2_k127_8146336_7	289376.THEYE_A1451	1.029e-62	218.0	COG0048@1|root,COG0048@2|Bacteria,3J0IU@40117|Nitrospirae	40117|Nitrospirae	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
TH2_k127_8146336_5	289376.THEYE_A1450	3.145e-71	243.0	COG0049@1|root,COG0049@2|Bacteria,3J0HK@40117|Nitrospirae	40117|Nitrospirae	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
TH2_k127_8146336_0	289376.THEYE_A1449	0.0	1128.0	COG0480@1|root,COG0480@2|Bacteria,3J0EK@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
TH2_k127_8146336_11	1123229.AUBC01000041_gene3825	1.49e-16	79.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,2TQP8@28211|Alphaproteobacteria,3JRYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
TH2_k127_8242847_25	338966.Ppro_1978	1.014e-50	186.0	COG2391@1|root,COG2391@2|Bacteria,1RDQK@1224|Proteobacteria,42RU6@68525|delta/epsilon subdivisions,2WNJT@28221|Deltaproteobacteria,43UP0@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
TH2_k127_8242847_26	909663.KI867150_gene2447	1.036e-49	184.0	COG1793@1|root,COG1793@2|Bacteria,1NTIR@1224|Proteobacteria,43022@68525|delta/epsilon subdivisions,2WV7R@28221|Deltaproteobacteria,2MRWD@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DNA polymerase Ligase (LigD)	-	-	-	-	-	-	-	-	-	-	-	-	LigD_N
TH2_k127_8242847_32	1121035.AUCH01000012_gene2916	1.341e-33	136.0	COG0526@1|root,COG0526@2|Bacteria,1MZ36@1224|Proteobacteria,2VTEA@28216|Betaproteobacteria,2KX3Z@206389|Rhodocyclales	206389|Rhodocyclales	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TH2_k127_8242847_40	1120977.JHUX01000003_gene747	0.0001985	54.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,3NIKG@468|Moraxellaceae	1236|Gammaproteobacteria	O	Belongs to the peptidase S1C family	mucD	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
TH2_k127_8242847_36	1131269.AQVV01000006_gene488	7.458e-22	110.0	COG0457@1|root,COG0457@2|Bacteria	1131269.AQVV01000006_gene488|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8242847_39	1232410.KI421412_gene22	1.111e-17	88.0	2EKQ7@1|root,33EDZ@2|Bacteria,1NHK0@1224|Proteobacteria,42WYF@68525|delta/epsilon subdivisions,2WSKJ@28221|Deltaproteobacteria,43VUS@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF2845)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2845
TH2_k127_8242847_21	589865.DaAHT2_0194	9.548e-60	213.0	COG2928@1|root,COG2928@2|Bacteria,1R79M@1224|Proteobacteria,42N61@68525|delta/epsilon subdivisions,2X5BT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
TH2_k127_8242847_12	909663.KI867150_gene2218	1.048e-87	301.0	COG1820@1|root,COG1820@2|Bacteria,1MW8Y@1224|Proteobacteria,430VJ@68525|delta/epsilon subdivisions,2WVQI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	-	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
TH2_k127_8242847_14	909663.KI867150_gene2219	4.869e-74	258.0	COG0657@1|root,COG0657@2|Bacteria,1R74D@1224|Proteobacteria,4379T@68525|delta/epsilon subdivisions,2X2DS@28221|Deltaproteobacteria,2MSHY@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	Protein of unknown function (DUF1460)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1460
TH2_k127_8242847_2	909663.KI867150_gene2220	1.313e-160	530.0	COG2211@1|root,COG2211@2|Bacteria,1QTSE@1224|Proteobacteria,43C8U@68525|delta/epsilon subdivisions,2X7J6@28221|Deltaproteobacteria,2MSKV@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Acetyl-coenzyme A transporter 1	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
TH2_k127_8242847_34	373903.Hore_22510	9.157e-24	109.0	2FHHE@1|root,349BF@2|Bacteria,1W18C@1239|Firmicutes,254D0@186801|Clostridia,3WC18@53433|Halanaerobiales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8242847_37	521045.Kole_0101	1.467e-21	97.0	COG1773@1|root,COG1773@2|Bacteria,2GDE5@200918|Thermotogae	200918|Thermotogae	C	PFAM Rubredoxin-type Fe(Cys)4 protein	-	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
TH2_k127_8242847_15	269799.Gmet_0141	2.094e-71	249.0	COG0755@1|root,COG0755@2|Bacteria	2|Bacteria	O	cytochrome complex assembly	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
TH2_k127_8242847_28	316067.Geob_3806	9.324e-44	168.0	COG1333@1|root,COG1333@2|Bacteria,1RIJF@1224|Proteobacteria,42T2N@68525|delta/epsilon subdivisions,2WPA1@28221|Deltaproteobacteria,43VTI@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	cytochrome c biogenesis protein	-	-	-	-	-	-	-	-	-	-	-	-	ResB
TH2_k127_8242847_29	1125863.JAFN01000001_gene3501	5.31e-43	171.0	COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,42U06@68525|delta/epsilon subdivisions,2WP2C@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Peptidase M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TH2_k127_8242847_33	338963.Pcar_0372	4.398e-27	111.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,42V0K@68525|delta/epsilon subdivisions,2WR92@28221|Deltaproteobacteria,43VE6@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	'Cold-shock' DNA-binding domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TH2_k127_8242847_19	449447.MAE_09770	7.28e-69	254.0	COG1472@1|root,COG1472@2|Bacteria,1G29F@1117|Cyanobacteria	1117|Cyanobacteria	G	PFAM Glycosyl hydrolase family 3 N terminal domain	bgl	-	3.2.1.21,3.2.1.52	ko:K01207,ko:K05349	ko00460,ko00500,ko00520,ko00531,ko00940,ko01100,ko01110,ko01501,map00460,map00500,map00520,map00531,map00940,map01100,map01110,map01501	M00628	R00022,R00026,R02558,R02887,R02985,R03527,R04949,R04998,R05963,R07809,R07810,R10035,R10039,R10040,R10831	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko00002,ko01000	-	GH3	-	Glyco_hydro_3
TH2_k127_8242847_10	1123376.AUIU01000016_gene198	9.538e-101	344.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
TH2_k127_8242847_6	289376.THEYE_A1458	3.866e-131	440.0	COG0457@1|root,COG0457@2|Bacteria,3J0MH@40117|Nitrospirae	40117|Nitrospirae	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_8
TH2_k127_8242847_17	289376.THEYE_A1457	7.644e-70	247.0	COG1947@1|root,COG1947@2|Bacteria,3J0N1@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
TH2_k127_8242847_7	671143.DAMO_0507	8.845e-130	421.0	COG0462@1|root,COG0462@2|Bacteria,2NNP6@2323|unclassified Bacteria	2|Bacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	GO:0003674,GO:0003824,GO:0004749,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2848	Pribosyl_synth,Pribosyltran_N
TH2_k127_8242847_20	289376.THEYE_A1454	3.118e-65	229.0	COG1825@1|root,COG1825@2|Bacteria,3J0NK@40117|Nitrospirae	40117|Nitrospirae	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
TH2_k127_8242847_22	289376.THEYE_A1453	1.324e-52	192.0	COG0193@1|root,COG0193@2|Bacteria,3J0QR@40117|Nitrospirae	40117|Nitrospirae	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
TH2_k127_8242847_11	1459636.NTE_00604	7.521e-98	338.0	COG0260@1|root,arCOG04322@2157|Archaea,41SYD@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
TH2_k127_8242847_23	289376.THEYE_A1452	4.226e-51	192.0	28Q1P@1|root,2ZCJY@2|Bacteria	2|Bacteria	S	Zinc dependent phospholipase C	-	-	-	-	-	-	-	-	-	-	-	-	Zn_dep_PLPC
TH2_k127_8242847_4	289377.HL41_08215	4.719e-138	450.0	COG0303@1|root,COG0303@2|Bacteria,2GGXT@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	MoeA C-terminal region (domain IV)	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
TH2_k127_8242847_3	1123376.AUIU01000014_gene619	4.158e-140	453.0	COG0409@1|root,COG0409@2|Bacteria,3J0W7@40117|Nitrospirae	40117|Nitrospirae	O	Hydrogenase formation hypA family	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
TH2_k127_8242847_30	713587.THITH_00755	3.432e-39	153.0	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,1RNTN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Methyltransferase	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
TH2_k127_8242847_13	56780.SYN_02484	2.376e-78	270.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	usp1	-	-	-	-	-	-	-	-	-	-	-	Usp
TH2_k127_8242847_0	56780.SYN_02485	0.0	1091.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8,3.6.3.9	ko:K01537,ko:K01539	ko04022,ko04024,ko04260,ko04261,ko04911,ko04918,ko04919,ko04925,ko04960,ko04961,ko04964,ko04970,ko04971,ko04972,ko04973,ko04974,ko04976,ko04978,map04022,map04024,map04260,map04261,map04911,map04918,map04919,map04925,map04960,map04961,map04964,map04970,map04971,map04972,map04973,map04974,map04976,map04978	-	-	-	ko00000,ko00001,ko01000,ko04147	3.A.3.1,3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,PTS_EIIA_2
TH2_k127_8242847_9	1121413.JMKT01000001_gene1726	2.475e-104	345.0	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,42NDF@68525|delta/epsilon subdivisions,2WJPS@28221|Deltaproteobacteria,2MAI6@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
TH2_k127_8242847_18	1454004.AW11_00394	5.898e-69	237.0	COG4564@1|root,COG4564@2|Bacteria,1RFW5@1224|Proteobacteria,2VTWN@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	sCache_2
TH2_k127_8242847_35	518766.Rmar_1190	4.964e-23	102.0	COG0642@1|root,COG2205@2|Bacteria,4PI8S@976|Bacteroidetes,1FK7X@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TH2_k127_8242847_1	1123376.AUIU01000012_gene1602	9.577e-252	792.0	COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,3J13A@40117|Nitrospirae	40117|Nitrospirae	K	PBP superfamily domain	-	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
TH2_k127_8242847_8	335543.Sfum_3190	2.12e-105	362.0	COG3894@1|root,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,42MF5@68525|delta/epsilon subdivisions,2WKC6@28221|Deltaproteobacteria,2MQU1@213462|Syntrophobacterales	68525|delta/epsilon subdivisions	C	PFAM 2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
TH2_k127_8242847_16	289376.THEYE_A1300	1.473e-70	252.0	COG0791@1|root,COG1388@1|root,COG0791@2|Bacteria,COG1388@2|Bacteria	2|Bacteria	M	LysM domain	xynZ	-	3.5.1.28	ko:K01449,ko:K19223	-	-	R04112	RC00064,RC00141	ko00000,ko01000,ko01002,ko01011	-	CBM50	-	DUF823,DUF824,Esterase,LysM,NLPC_P60
TH2_k127_8242847_24	289376.THEYE_A1299	6.641e-51	187.0	COG1386@1|root,COG1386@2|Bacteria,3J15Z@40117|Nitrospirae	40117|Nitrospirae	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
TH2_k127_8242847_27	1125863.JAFN01000001_gene3021	1.45e-48	188.0	COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,42QRZ@68525|delta/epsilon subdivisions,2WMZS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	-	-	5.3.4.1	ko:K03981	-	-	-	-	ko00000,ko01000,ko02044,ko03110	3.A.7.11.1	-	-	DsbC_N,Thioredoxin_2
TH2_k127_8242847_31	243231.GSU1319	2.031e-37	152.0	COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,43C4K@68525|delta/epsilon subdivisions,2X7F1@28221|Deltaproteobacteria,43TX3@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Domains HisKA, HATPase_c	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TH2_k127_8242847_5	1379698.RBG1_1C00001G1265	6.483e-137	450.0	COG2204@1|root,COG2204@2|Bacteria,2NNWS@2323|unclassified Bacteria	2|Bacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH2_k127_8358664_23	404589.Anae109_0807	1.006e-31	130.0	COG4276@1|root,COG4276@2|Bacteria,1N6EC@1224|Proteobacteria,42U3N@68525|delta/epsilon subdivisions,2WQTN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Pfam Polyketide cyclase dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
TH2_k127_8358664_25	690850.Desaf_3453	6.714e-11	64.0	COG1715@1|root,COG1715@2|Bacteria,1Q2VY@1224|Proteobacteria,42PSS@68525|delta/epsilon subdivisions,2WKGZ@28221|Deltaproteobacteria,2MBKW@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Mrr N-terminal domain	-	-	-	ko:K07448	-	-	-	-	ko00000,ko02048	-	-	-	HARE-HTH,Mrr_N,Mrr_cat
TH2_k127_8358664_1	269799.Gmet_2696	3.178e-275	859.0	COG1966@1|root,COG1966@2|Bacteria,1MWF9@1224|Proteobacteria,42NBI@68525|delta/epsilon subdivisions,2WM33@28221|Deltaproteobacteria,43TTR@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	5TM C-terminal transporter carbon starvation CstA	cstA-2	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
TH2_k127_8358664_19	665571.STHERM_c16890	6.658e-42	163.0	COG2935@1|root,COG2935@2|Bacteria,2J8BW@203691|Spirochaetes	203691|Spirochaetes	O	Arginine-tRNA-protein transferase, N terminus	-	-	2.3.2.29	ko:K21420	-	-	R11547,R11548	RC00064	ko00000,ko01000	-	-	-	ATE_C,ATE_N
TH2_k127_8358664_3	1125863.JAFN01000001_gene1744	1.135e-172	559.0	COG0535@1|root,COG0535@2|Bacteria,1R58E@1224|Proteobacteria,42NSA@68525|delta/epsilon subdivisions,2WJVH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
TH2_k127_8358664_5	1191523.MROS_1670	7.032e-163	526.0	COG2252@1|root,COG2252@2|Bacteria	2|Bacteria	S	purine nucleobase transmembrane transporter activity	yicO	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
TH2_k127_8358664_26	278963.ATWD01000001_gene3582	1.856e-09	61.0	2EA3B@1|root,3348D@2|Bacteria,3Y5J1@57723|Acidobacteria,2JJZE@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8358664_6	1163617.SCD_n02200	1.7e-159	520.0	COG3267@1|root,COG3409@1|root,COG3267@2|Bacteria,COG3409@2|Bacteria,1MU3G@1224|Proteobacteria,2VIK1@28216|Betaproteobacteria	28216|Betaproteobacteria	U	SMART AAA ATPase	exeA	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1
TH2_k127_8358664_24	1538295.JY96_04865	5.576e-19	99.0	2CEXV@1|root,32S0S@2|Bacteria,1MZKB@1224|Proteobacteria,2VU8J@28216|Betaproteobacteria,1KMC0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Type II secretion system protein B	gspB	-	-	ko:K02451	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	T2SSB
TH2_k127_8358664_18	1191523.MROS_1767	1.215e-54	200.0	COG3298@1|root,COG3298@2|Bacteria	2|Bacteria	L	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB	wlaX	-	-	ko:K07501	-	-	-	-	ko00000	-	-	-	DNA_pol_B_exo2
TH2_k127_8358664_4	289376.THEYE_A1481	2.715e-165	530.0	COG0793@1|root,COG0793@2|Bacteria,3J09Y@40117|Nitrospirae	40117|Nitrospirae	M	tail specific protease	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,Peptidase_S41
TH2_k127_8358664_13	289376.THEYE_A1482	2.678e-74	270.0	COG4942@1|root,COG4942@2|Bacteria,3J0SP@40117|Nitrospirae	40117|Nitrospirae	D	Peptidase family M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
TH2_k127_8358664_21	1123376.AUIU01000015_gene453	1.777e-39	158.0	COG2177@1|root,COG2177@2|Bacteria,3J18Q@40117|Nitrospirae	40117|Nitrospirae	D	Belongs to the ABC-4 integral membrane protein family. FtsX subfamily	-	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
TH2_k127_8358664_14	289376.THEYE_A1484	2.572e-71	247.0	COG2884@1|root,COG2884@2|Bacteria,3J139@40117|Nitrospirae	40117|Nitrospirae	D	ABC transporter	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
TH2_k127_8358664_7	289376.THEYE_A1485	3.472e-132	428.0	COG3958@1|root,COG3958@2|Bacteria,3J1FK@40117|Nitrospirae	40117|Nitrospirae	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
TH2_k127_8358664_8	1123376.AUIU01000015_gene456	1.63e-124	410.0	COG3959@1|root,COG3959@2|Bacteria,3J1FM@40117|Nitrospirae	40117|Nitrospirae	G	Dehydrogenase E1 component	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
TH2_k127_8358664_20	289376.THEYE_A0087	4.394e-41	165.0	COG0095@1|root,COG0095@2|Bacteria	2|Bacteria	H	Lipoate-protein ligase	lipM	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
TH2_k127_8358664_15	525897.Dbac_3376	2.151e-67	238.0	COG3494@1|root,COG3494@2|Bacteria,1MWTH@1224|Proteobacteria,42P40@68525|delta/epsilon subdivisions,2WK7K@28221|Deltaproteobacteria,2M8IK@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1009)	-	-	-	ko:K09949	-	-	-	-	ko00000	-	-	-	DUF1009
TH2_k127_8358664_9	289376.THEYE_A0090	2.139e-108	357.0	COG1043@1|root,COG1043@2|Bacteria,3J0G6@40117|Nitrospirae	40117|Nitrospirae	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
TH2_k127_8358664_16	1123376.AUIU01000012_gene1503	1.115e-60	217.0	COG0764@1|root,COG0764@2|Bacteria,3J0NG@40117|Nitrospirae	40117|Nitrospirae	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
TH2_k127_8358664_10	289376.THEYE_A0092	3.192e-107	359.0	COG1044@1|root,COG1044@2|Bacteria,3J0GQ@40117|Nitrospirae	40117|Nitrospirae	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,LpxD
TH2_k127_8358664_22	1123376.AUIU01000012_gene1501	1.71e-34	139.0	COG2825@1|root,COG2825@2|Bacteria,3J1AH@40117|Nitrospirae	40117|Nitrospirae	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
TH2_k127_8358664_2	289376.THEYE_A0094	1.182e-259	851.0	COG4775@1|root,COG4775@2|Bacteria,3J0AC@40117|Nitrospirae	40117|Nitrospirae	M	Surface antigen	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
TH2_k127_8358664_0	289376.THEYE_A0099	2.669e-295	916.0	COG0481@1|root,COG0481@2|Bacteria,3J0D1@40117|Nitrospirae	40117|Nitrospirae	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
TH2_k127_8358664_11	289376.THEYE_A0098	2.853e-86	291.0	COG0681@1|root,COG0681@2|Bacteria,3J0IP@40117|Nitrospirae	40117|Nitrospirae	U	Signal peptidase, peptidase S26	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
TH2_k127_8358664_17	289376.THEYE_A0097	5.781e-58	209.0	COG0307@1|root,COG0307@2|Bacteria,3J0PR@40117|Nitrospirae	40117|Nitrospirae	H	Lumazine binding domain	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
TH2_k127_8358664_12	1123376.AUIU01000018_gene46	1.123e-77	263.0	COG0188@1|root,COG0188@2|Bacteria,3J0EH@40117|Nitrospirae	40117|Nitrospirae	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
TH2_k127_8432442_13	90371.CY43_08355	1.042e-19	104.0	COG5305@1|root,COG5305@2|Bacteria,1R9UF@1224|Proteobacteria,1S0JK@1236|Gammaproteobacteria,3ZMYJ@590|Salmonella	1236|Gammaproteobacteria	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TH2_k127_8432442_3	1089553.Tph_c26530	2.004e-107	359.0	COG0512@1|root,COG0547@1|root,COG0512@2|Bacteria,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,247WY@186801|Clostridia,42EK5@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
TH2_k127_8432442_4	1123376.AUIU01000018_gene71	1.529e-91	306.0	COG0512@1|root,COG0512@2|Bacteria,3J0H8@40117|Nitrospirae	40117|Nitrospirae	EH	Peptidase C26	-	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
TH2_k127_8432442_1	880072.Desac_1832	1.094e-165	535.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,42MXN@68525|delta/epsilon subdivisions,2WJN0@28221|Deltaproteobacteria,2MQ88@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657,ko:K13503	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
TH2_k127_8432442_10	671143.DAMO_2487	1.247e-52	189.0	COG4968@1|root,COG4968@2|Bacteria	2|Bacteria	NU	Prokaryotic N-terminal methylation motif	lspG	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
TH2_k127_8432442_9	1303518.CCALI_00163	7.155e-53	212.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Metallophos
TH2_k127_8432442_0	909663.KI867150_gene2892	1.863e-183	595.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria,2MQD2@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	PFAM UvrD REP helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
TH2_k127_8432442_2	269799.Gmet_2726	5.013e-130	420.0	COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,42N0U@68525|delta/epsilon subdivisions,2WJH3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
TH2_k127_8432442_11	1123376.AUIU01000011_gene935	4.951e-35	145.0	COG0727@1|root,COG0727@2|Bacteria	2|Bacteria	S	metal cluster binding	-	-	-	ko:K06940,ko:K18475	-	-	-	-	ko00000,ko01000,ko02035	-	-	-	CxxCxxCC
TH2_k127_8432442_12	580332.Slit_1870	3.135e-27	121.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
TH2_k127_8432442_6	644282.Deba_2972	2.766e-69	244.0	COG2041@1|root,COG2041@2|Bacteria,1MWZK@1224|Proteobacteria,43AZC@68525|delta/epsilon subdivisions,2WPPS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
TH2_k127_8432442_5	1123376.AUIU01000007_gene1188	1.046e-90	306.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
TH2_k127_8432442_7	502025.Hoch_3949	9.486e-60	216.0	COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,42R50@68525|delta/epsilon subdivisions,2X3AE@28221|Deltaproteobacteria,2YV4E@29|Myxococcales	28221|Deltaproteobacteria	S	nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
TH2_k127_8432442_8	1500894.JQNN01000001_gene1098	2.264e-59	217.0	COG1446@1|root,COG1446@2|Bacteria,1MWFC@1224|Proteobacteria,2VIYM@28216|Betaproteobacteria,4752H@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Asparaginase	iaaA	-	3.4.19.5,3.5.1.1	ko:K01424,ko:K13051	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000,ko01002	-	-	-	Asparaginase_2
TH2_k127_8459446_4	1123376.AUIU01000016_gene207	4.14e-131	431.0	COG0772@1|root,COG0772@2|Bacteria,3J0M8@40117|Nitrospirae	40117|Nitrospirae	D	Cell cycle protein	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
TH2_k127_8459446_6	671143.DAMO_2299	1.541e-118	398.0	COG0771@1|root,COG0771@2|Bacteria,2NP27@2323|unclassified Bacteria	2|Bacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008764,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iAPECO1_1312.APECO1_1898,iECNA114_1301.ECNA114_0081,iECOK1_1307.ECOK1_0089,iECP_1309.ECP_0090,iECS88_1305.ECS88_0091,iECSF_1327.ECSF_0098,iLF82_1304.LF82_1418,iNRG857_1313.NRG857_00450,iUMN146_1321.UM146_23225,iUTI89_1310.UTI89_C0097	Mur_ligase_C,Mur_ligase_M
TH2_k127_8459446_14	289376.THEYE_A1325	3.359e-77	271.0	COG1686@1|root,COG1686@2|Bacteria,3J179@40117|Nitrospirae	40117|Nitrospirae	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
TH2_k127_8459446_2	289376.THEYE_A1326	1.169e-162	519.0	COG0472@1|root,COG0472@2|Bacteria,3J0C4@40117|Nitrospirae	40117|Nitrospirae	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
TH2_k127_8459446_10	289376.THEYE_A1327	6.705e-101	348.0	COG0770@1|root,COG0770@2|Bacteria,3J0PW@40117|Nitrospirae	40117|Nitrospirae	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TH2_k127_8459446_3	289376.THEYE_A1328	1.355e-140	465.0	COG0769@1|root,COG0769@2|Bacteria,3J0DS@40117|Nitrospirae	40117|Nitrospirae	M	acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TH2_k127_8459446_1	1123376.AUIU01000016_gene213	7.305e-203	649.0	COG0768@1|root,COG0768@2|Bacteria,3J0FH@40117|Nitrospirae	40117|Nitrospirae	M	Penicillin-binding Protein dimerisation domain	-	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
TH2_k127_8459446_11	1123376.AUIU01000016_gene215	2.207e-93	314.0	COG0275@1|root,COG0275@2|Bacteria,3J0NU@40117|Nitrospirae	40117|Nitrospirae	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	mraW	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
TH2_k127_8459446_17	289376.THEYE_A1332	1.11e-57	204.0	COG2001@1|root,COG2001@2|Bacteria,3J0VQ@40117|Nitrospirae	40117|Nitrospirae	K	MraZ protein, putative antitoxin-like	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
TH2_k127_8459446_12	2325.TKV_c07340	1.143e-81	286.0	COG0156@1|root,COG0156@2|Bacteria,1TPUX@1239|Firmicutes,2491D@186801|Clostridia,42FUG@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Aminotransferase class I and II	bioF	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29,2.3.1.47,6.2.1.14	ko:K00639,ko:K00652,ko:K01906	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03209,R03210,R10124	RC00004,RC00014,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2,BioW
TH2_k127_8459446_7	289376.THEYE_A0581	3.249e-112	372.0	COG0240@1|root,COG0240@2|Bacteria,3J0GP@40117|Nitrospirae	40117|Nitrospirae	I	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
TH2_k127_8459446_15	338966.Ppro_0625	3.398e-72	251.0	COG1691@1|root,COG1691@2|Bacteria,1REQ7@1224|Proteobacteria,42MJG@68525|delta/epsilon subdivisions,2WN0G@28221|Deltaproteobacteria,43U0V@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
TH2_k127_8459446_19	289376.THEYE_A0582	5.235e-26	112.0	COG0454@1|root,COG0456@2|Bacteria,3J1CI@40117|Nitrospirae	40117|Nitrospirae	K	Acetyltransferase (GNAT) domain	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
TH2_k127_8459446_18	1123376.AUIU01000012_gene1455	7.526e-55	208.0	COG1214@1|root,COG1214@2|Bacteria,3J0VU@40117|Nitrospirae	40117|Nitrospirae	O	Glycoprotease family	-	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
TH2_k127_8459446_8	289376.THEYE_A1311	3.979e-107	360.0	COG0477@1|root,COG2814@2|Bacteria,3J0RT@40117|Nitrospirae	40117|Nitrospirae	EGP	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
TH2_k127_8459446_9	289376.THEYE_A1296	3.195e-102	340.0	COG1376@1|root,COG1388@1|root,COG1376@2|Bacteria,COG1388@2|Bacteria	2|Bacteria	M	LysM domain	-	-	-	ko:K16291	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	LysM,YkuD
TH2_k127_8459446_24	1122194.AUHU01000002_gene2851	2.382e-05	51.0	2EJ6D@1|root,33CXK@2|Bacteria,1NHGW@1224|Proteobacteria,1SGZR@1236|Gammaproteobacteria,46C71@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8459446_16	706587.Desti_3921	1.313e-71	248.0	COG2080@1|root,COG2080@2|Bacteria,1MY3F@1224|Proteobacteria,43AMR@68525|delta/epsilon subdivisions,2X61U@28221|Deltaproteobacteria,2MRMX@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	2Fe-2S -binding domain	-	-	-	ko:K13483	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002	-	-	-	Fer2,Fer2_2
TH2_k127_8459446_0	706587.Desti_3922	0.0	1079.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2MR87@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2_2
TH2_k127_8459446_5	335543.Sfum_2511	4.408e-121	396.0	COG1319@1|root,COG1319@2|Bacteria,1MVJS@1224|Proteobacteria,42RX4@68525|delta/epsilon subdivisions,2WNBJ@28221|Deltaproteobacteria,2MQZF@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.17.1.4	ko:K11178	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
TH2_k127_8459446_22	1123371.ATXH01000023_gene938	5.621e-11	65.0	2ED51@1|root,3371S@2|Bacteria,2GIK1@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8459446_13	1304872.JAGC01000009_gene244	2.324e-80	281.0	COG0642@1|root,COG2205@2|Bacteria,1QHXX@1224|Proteobacteria,42NW1@68525|delta/epsilon subdivisions,2WJUF@28221|Deltaproteobacteria,2M85B@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
TH2_k127_8768711_0	589865.DaAHT2_2131	1.067e-167	530.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,42N8V@68525|delta/epsilon subdivisions,2WJWB@28221|Deltaproteobacteria,2MMVM@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Pirin	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
TH2_k127_8768711_5	269799.Gmet_0269	3.537e-47	174.0	2D2K4@1|root,32TD0@2|Bacteria,1MZKF@1224|Proteobacteria,42TFV@68525|delta/epsilon subdivisions,2WQ7B@28221|Deltaproteobacteria,43VAM@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF3124)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3124
TH2_k127_8768711_3	289376.THEYE_A0133	8.588e-87	292.0	COG1611@1|root,COG1611@2|Bacteria,3J169@40117|Nitrospirae	40117|Nitrospirae	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
TH2_k127_8768711_1	909663.KI867150_gene1129	3.071e-163	526.0	COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,42NDS@68525|delta/epsilon subdivisions,2WJDE@28221|Deltaproteobacteria,2MQKI@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	RmuC family	-	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
TH2_k127_8768711_4	289376.THEYE_A0132	1.085e-51	186.0	COG0234@1|root,COG0234@2|Bacteria	2|Bacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
TH2_k127_8768711_6	316067.Geob_3447	2.225e-23	106.0	COG0457@1|root,COG0457@2|Bacteria,1N0Q1@1224|Proteobacteria,42TBT@68525|delta/epsilon subdivisions,2WPII@28221|Deltaproteobacteria,43V2H@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
TH2_k127_8768711_7	443143.GM18_3041	1.23e-20	94.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TH2_k127_8768711_2	398767.Glov_0956	7.795e-108	357.0	2AAQ3@1|root,31026@2|Bacteria,1PN2B@1224|Proteobacteria,4313Y@68525|delta/epsilon subdivisions,2WWKT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_94420_0	1123376.AUIU01000015_gene478	4.474e-187	595.0	COG2509@1|root,COG2509@2|Bacteria	2|Bacteria	H	5-formyltetrahydrofolate cyclo-ligase activity	IV02_08645	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	FAD_binding_2,HI0933_like,Pyr_redox_2
TH2_k127_94420_1	338966.Ppro_2839	4.006e-172	548.0	COG1812@1|root,COG1812@2|Bacteria,1QPB9@1224|Proteobacteria,42YHC@68525|delta/epsilon subdivisions,2WTU3@28221|Deltaproteobacteria,43UEK@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	S-adenosylmethionine synthetase (AdoMet synthetase)	metK-2	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_Synthase
TH2_k127_94420_4	243231.GSU1615	7.395e-113	379.0	COG0526@1|root,COG0526@2|Bacteria,1MWDE@1224|Proteobacteria,42RCT@68525|delta/epsilon subdivisions,2WKJ9@28221|Deltaproteobacteria,43UJX@69541|Desulfuromonadales	28221|Deltaproteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
TH2_k127_94420_11	404380.Gbem_1764	4.384e-06	53.0	2DE7M@1|root,2ZKVC@2|Bacteria,1P4KV@1224|Proteobacteria,432ZE@68525|delta/epsilon subdivisions,2WXP0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_94420_2	530564.Psta_1423	1.962e-161	518.0	COG0448@1|root,COG0448@2|Bacteria,2IXP5@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TH2_k127_94420_8	289376.THEYE_A0530	1.038e-38	149.0	COG5483@1|root,COG5483@2|Bacteria	2|Bacteria	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
TH2_k127_94420_6	589865.DaAHT2_1950	4.578e-71	244.0	COG1418@1|root,COG1418@2|Bacteria,1RJ5Y@1224|Proteobacteria,42SYN@68525|delta/epsilon subdivisions,2WP8J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	SMART metal-dependent phosphohydrolase, HD region	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
TH2_k127_94420_7	234267.Acid_7481	1.775e-63	227.0	COG3409@1|root,COG3409@2|Bacteria,3Y66V@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	Muraidase
TH2_k127_94420_9	1286631.X805_03240	3.028e-15	82.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2W3RM@28216|Betaproteobacteria,1KJNH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TH2_k127_94420_10	715451.ambt_05760	1.062e-07	65.0	2EKF0@1|root,33E57@2|Bacteria,1NHTV@1224|Proteobacteria,1SH2Y@1236|Gammaproteobacteria,46BY9@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_94420_3	1232410.KI421418_gene2172	4.027e-146	477.0	COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,42ND1@68525|delta/epsilon subdivisions,2X753@28221|Deltaproteobacteria,43VYU@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
TH2_k127_94420_5	1232410.KI421421_gene3767	1.302e-95	321.0	COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,42QPB@68525|delta/epsilon subdivisions,2WMP0@28221|Deltaproteobacteria,43T71@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	response regulator	-	-	-	ko:K07664	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TH2_k127_94420_12	316067.Geob_0763	0.0001411	45.0	COG3245@1|root,COG3245@2|Bacteria,1RJCX@1224|Proteobacteria	1224|Proteobacteria	C	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
TH2_k127_980702_10	1134474.O59_002785	2.849e-31	130.0	COG0226@1|root,COG2885@1|root,COG0226@2|Bacteria,COG2885@2|Bacteria,1MVXP@1224|Proteobacteria,1RNK7@1236|Gammaproteobacteria,1FGIZ@10|Cellvibrio	1236|Gammaproteobacteria	MP	PBP superfamily domain	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	OmpA,PBP_like_2
TH2_k127_980702_4	1123376.AUIU01000011_gene908	1.445e-66	230.0	COG0782@1|root,COG0782@2|Bacteria,3J0NA@40117|Nitrospirae	40117|Nitrospirae	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
TH2_k127_980702_6	289376.THEYE_A0542	5.325e-55	201.0	COG0543@1|root,COG0543@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	pyrK	-	1.3.1.14,3.5.2.3	ko:K01465,ko:K02823,ko:K05784,ko:K17828	ko00240,ko00362,ko00364,ko00622,ko01100,ko01120,ko01220,map00240,map00362,map00364,map00622,map01100,map01120,map01220	M00051,M00551	R01869,R01993,R05290,R05291,R05428,R05621,R05622,R05665,R08100,R08101,R08108,R08109,R08110	RC00051,RC00270,RC00632,RC01378,RC01450,RC01910	br01602,ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS17580	DHODB_Fe-S_bind,FAD_binding_6,Fer2,NAD_binding_1
TH2_k127_980702_1	289376.THEYE_A0543	4.058e-118	389.0	COG0167@1|root,COG0167@2|Bacteria,3J145@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.14,1.3.98.1	ko:K00226,ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01867,R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
TH2_k127_980702_5	1379270.AUXF01000003_gene3481	5.79e-57	208.0	COG1912@1|root,COG1912@2|Bacteria,1ZTIH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
TH2_k127_980702_3	1123376.AUIU01000014_gene686	6.004e-92	312.0	COG0767@1|root,COG0767@2|Bacteria,3J0I7@40117|Nitrospirae	40117|Nitrospirae	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
TH2_k127_980702_2	289376.THEYE_A0879	5.063e-92	321.0	COG1127@1|root,COG1127@2|Bacteria,3J0J2@40117|Nitrospirae	40117|Nitrospirae	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
TH2_k127_980702_8	671143.DAMO_2219	9.106e-47	173.0	COG1463@1|root,COG1463@2|Bacteria,2NRY6@2323|unclassified Bacteria	2|Bacteria	Q	MlaD protein	yrbD	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
TH2_k127_980702_7	671143.DAMO_2217	1.925e-52	192.0	COG2854@1|root,COG2854@2|Bacteria	2|Bacteria	Q	intermembrane phospholipid transfer	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
TH2_k127_980702_9	443144.GM21_2061	2.185e-46	184.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	zraS	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010043,GO:0010288,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031226,GO:0035556,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071241,GO:0071248,GO:0071284,GO:0071294,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K07709	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,sCache_3_2
TH2_k127_980702_0	243231.GSU0470	6.4e-136	446.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,43UCF@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	response regulator	-	-	-	ko:K10943	ko02020,ko05111,map02020,map05111	M00515	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH2_k127_980702_11	404380.Gbem_2159	6.429e-17	87.0	2BZE7@1|root,33GIR@2|Bacteria,1NZV2@1224|Proteobacteria,4316Q@68525|delta/epsilon subdivisions,2WWDQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_980702_12	667014.Thein_1386	3.381e-12	73.0	2A9J6@1|root,2ZY78@2|Bacteria,2GIKB@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_98752_11	1122194.AUHU01000002_gene2735	7.545e-10	60.0	COG3735@1|root,COG3735@2|Bacteria,1MVCW@1224|Proteobacteria,1RRI8@1236|Gammaproteobacteria,4659X@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	ybaP	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
TH2_k127_98752_4	1450525.JATV01000013_gene2901	3.953e-145	465.0	COG0031@1|root,COG0031@2|Bacteria,4NDZ9@976|Bacteroidetes,1IIGW@117743|Flavobacteriia,2NSTS@237|Flavobacterium	976|Bacteroidetes	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738,ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TH2_k127_98752_3	269799.Gmet_2510	1.123e-156	499.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,42N06@68525|delta/epsilon subdivisions,2WK5N@28221|Deltaproteobacteria,43T7Z@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Transketolase, pyrimidine binding domain	bkdB	-	1.2.4.1,1.2.4.4	ko:K00162,ko:K00167	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
TH2_k127_98752_6	243231.GSU2654	8.472e-136	441.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,42NW8@68525|delta/epsilon subdivisions,2WJY1@28221|Deltaproteobacteria,43UJJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Dehydrogenase E1 component	bkdA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
TH2_k127_98752_5	443144.GM21_0478	1.79e-139	453.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NK7@68525|delta/epsilon subdivisions,2WKTV@28221|Deltaproteobacteria,43RYC@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
TH2_k127_98752_7	289376.THEYE_A0454	1.237e-94	317.0	COG0313@1|root,COG0313@2|Bacteria,3J0PU@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
TH2_k127_98752_9	459349.CLOAM1710	4.139e-20	96.0	COG1633@1|root,COG1633@2|Bacteria,2NS04@2323|unclassified Bacteria	2|Bacteria	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin,VIT1
TH2_k127_98752_1	1379698.RBG1_1C00001G0755	3.467e-199	641.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2NNW4@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses	nadE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
TH2_k127_98752_8	1232410.KI421415_gene3008	8.893e-55	204.0	COG4122@1|root,COG4122@2|Bacteria,1QWN3@1224|Proteobacteria,43DC9@68525|delta/epsilon subdivisions,2X8IA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
TH2_k127_98752_0	56780.SYN_02218	0.0	1096.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
TH2_k127_98752_2	234267.Acid_4959	1.816e-174	573.0	COG0784@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,3Y63K@57723|Acidobacteria	57723|Acidobacteria	T	ATP-binding region, ATPase domain protein domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_9,Response_reg
## 1702 queries scanned
## Total time (seconds): 310.2470099925995
## Rate: 5.49 q/s