## Thu Oct 17 10:45:57 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/Potential_rubisco_autotrophic/TH2_bin.4.fa -m mmseqs --itype genome -o TH2_bin.4 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/all_bins_1385/TH2_bin.4 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
TH2_k127_1025779_0	696747.NIES39_J01250	3.453e-61	233.0	COG0517@1|root,COG2199@1|root,COG2202@1|root,COG2203@1|root,COG0517@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria,1FZWU@1117|Cyanobacteria,1H9RR@1150|Oscillatoriales	1117|Cyanobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,GAF_2,GAF_3,GGDEF,PAS_3,PAS_9
TH2_k127_1025779_1	1237149.C900_01498	4.831e-30	137.0	COG4251@1|root,COG5000@1|root,COG4251@2|Bacteria,COG5000@2|Bacteria,4NDUQ@976|Bacteroidetes,47PTN@768503|Cytophagia	976|Bacteroidetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HAMP,HATPase_c,HisKA,PAS_3,PAS_9,Response_reg
TH2_k127_1025932_7	1156937.MFUM_790015	3.673e-116	386.0	COG0322@1|root,COG0322@2|Bacteria,46SAJ@74201|Verrucomicrobia,37GFU@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
TH2_k127_1025932_21	338963.Pcar_1476	1.42e-34	147.0	28N9P@1|root,2ZBDN@2|Bacteria,1R70P@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF3592)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3592
TH2_k127_1025932_4	266117.Rxyl_3138	4.415e-139	451.0	COG1533@1|root,COG1533@2|Bacteria,2GM31@201174|Actinobacteria,4CQAG@84995|Rubrobacteria	84995|Rubrobacteria	L	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TH2_k127_1025932_16	344747.PM8797T_22573	1.693e-49	183.0	COG0394@1|root,COG0394@2|Bacteria,2J115@203682|Planctomycetes	203682|Planctomycetes	T	Low molecular weight phosphotyrosine protein phosphatase	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
TH2_k127_1025932_10	1223523.H340_22836	7.745e-100	343.0	COG0665@1|root,COG0665@2|Bacteria,2GJQ9@201174|Actinobacteria	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
TH2_k127_1025932_9	1379698.RBG1_1C00001G0123	3.142e-106	353.0	COG0053@1|root,COG0053@2|Bacteria,2NPHA@2323|unclassified Bacteria	2|Bacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	fieF	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
TH2_k127_1025932_19	1267535.KB906767_gene3226	1.75e-42	164.0	COG1595@1|root,COG1595@2|Bacteria,3Y3BS@57723|Acidobacteria,2JIDF@204432|Acidobacteriia	204432|Acidobacteriia	K	RNA polymerase sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TH2_k127_1025932_3	497964.CfE428DRAFT_2490	4.545e-142	472.0	COG0497@1|root,COG0497@2|Bacteria,46SGB@74201|Verrucomicrobia	74201|Verrucomicrobia	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
TH2_k127_1025932_15	497964.CfE428DRAFT_6199	4.354e-52	192.0	2ECN9@1|root,336K5@2|Bacteria,46T7K@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1025932_23	1232410.KI421425_gene1556	2.649e-21	99.0	COG3212@1|root,COG3212@2|Bacteria,1N0D3@1224|Proteobacteria	1224|Proteobacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	PepSY
TH2_k127_1025932_22	1289387.AUKW01000003_gene2481	1.984e-30	138.0	COG1653@1|root,COG1653@2|Bacteria,2GNJW@201174|Actinobacteria	201174|Actinobacteria	G	solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
TH2_k127_1025932_8	497964.CfE428DRAFT_6149	2.218e-115	393.0	COG2103@1|root,COG2971@1|root,COG2103@2|Bacteria,COG2971@2|Bacteria,46SJI@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,SIS_2
TH2_k127_1025932_17	794903.OPIT5_17080	1.433e-48	195.0	COG0662@1|root,COG2169@1|root,COG0662@2|Bacteria,COG2169@2|Bacteria,46Z7U@74201|Verrucomicrobia,3K9T9@414999|Opitutae	414999|Opitutae	K	AraC-like ligand binding domain	-	-	-	ko:K03490	-	-	-	-	ko00000,ko03000	-	-	-	HTH_18
TH2_k127_1025932_13	1303518.CCALI_01123	4.343e-77	271.0	COG5285@1|root,COG5285@2|Bacteria	2|Bacteria	Q	dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
TH2_k127_1025932_11	1232453.BAIF02000051_gene984	1.304e-98	337.0	COG0407@1|root,COG0407@2|Bacteria,1V2TK@1239|Firmicutes,24FVW@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
TH2_k127_1025932_6	1142394.PSMK_30380	6.543e-119	412.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Trehalase
TH2_k127_1025932_0	234267.Acid_7180	2.247e-247	782.0	COG1331@1|root,COG1331@2|Bacteria,3Y3AA@57723|Acidobacteria	57723|Acidobacteria	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
TH2_k127_1025932_5	478741.JAFS01000002_gene786	1.057e-122	404.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,46SM2@74201|Verrucomicrobia,37GEE@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
TH2_k127_1025932_20	880072.Desac_2741	8.446e-41	171.0	COG0265@1|root,COG0457@1|root,COG0265@2|Bacteria,COG0457@2|Bacteria,1NE6G@1224|Proteobacteria,4321S@68525|delta/epsilon subdivisions,2WWD7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
TH2_k127_1025932_26	166318.Syn8016DRAFT_2432	0.0005355	53.0	COG0457@1|root,COG0463@1|root,COG0457@2|Bacteria,COG0463@2|Bacteria,1G0II@1117|Cyanobacteria,1GYS6@1129|Synechococcus	1117|Cyanobacteria	M	COG0463 Glycosyltransferases involved in cell wall biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,TPR_1,TPR_16,TPR_2,TPR_8
TH2_k127_1025932_18	796606.BMMGA3_08440	4.971e-44	165.0	COG0432@1|root,COG0432@2|Bacteria,1V6J7@1239|Firmicutes,4HI2R@91061|Bacilli,1ZGBA@1386|Bacillus	91061|Bacilli	S	Uncharacterised protein family UPF0047	yugU	-	-	-	-	-	-	-	-	-	-	-	UPF0047
TH2_k127_1025932_12	1121904.ARBP01000025_gene6099	4.311e-94	328.0	COG5434@1|root,COG5434@2|Bacteria,4NICS@976|Bacteroidetes	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 28 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_28,Pectate_lyase_3
TH2_k127_1025932_2	411477.PARMER_02901	9.332e-147	477.0	COG3635@1|root,COG3635@2|Bacteria,4NH0F@976|Bacteroidetes,2FMC7@200643|Bacteroidia,22W6J@171551|Porphyromonadaceae	976|Bacteroidetes	G	2,3-bisphosphoglycerate-independent phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
TH2_k127_1025932_1	240016.ABIZ01000001_gene2642	4.931e-239	749.0	COG0504@1|root,COG0504@2|Bacteria,46S8K@74201|Verrucomicrobia,2ITX8@203494|Verrucomicrobiae	203494|Verrucomicrobiae	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
TH2_k127_1025932_14	1379698.RBG1_1C00001G0541	3.397e-73	259.0	COG1212@1|root,COG1212@2|Bacteria,2NP8R@2323|unclassified Bacteria	2|Bacteria	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
TH2_k127_1025932_24	246197.MXAN_4639	1.746e-09	69.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,42P5H@68525|delta/epsilon subdivisions,2WKAU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_4,TPR_6,TPR_7,TPR_8
TH2_k127_1083678_8	234267.Acid_4498	6.163e-89	303.0	29MQ2@1|root,308MT@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1083678_6	1449065.JMLL01000003_gene2954	1.224e-105	351.0	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,2U1SQ@28211|Alphaproteobacteria,43NFF@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
TH2_k127_1083678_15	1353531.AZNX01000037_gene3804	3.198e-08	66.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4BCDP@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
TH2_k127_1083678_11	96561.Dole_3137	1.339e-80	282.0	COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,42NJU@68525|delta/epsilon subdivisions,2WKA6@28221|Deltaproteobacteria,2MJK5@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
TH2_k127_1083678_2	247490.KSU1_C1449	1.03e-175	559.0	28HMZ@1|root,2Z7WD@2|Bacteria,2J2EK@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
TH2_k127_1083678_12	501479.ACNW01000062_gene2740	1.996e-59	215.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
TH2_k127_1083678_5	237368.SCABRO_02891	8.721e-129	422.0	COG2370@1|root,COG2370@2|Bacteria,2J0KW@203682|Planctomycetes	203682|Planctomycetes	O	HupE / UreJ protein	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ_2
TH2_k127_1083678_9	1283300.ATXB01000001_gene390	8.922e-87	307.0	COG0760@1|root,COG0760@2|Bacteria,1R4ZR@1224|Proteobacteria,1SEDW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	PPIC-type PPIASE domain	-	-	-	-	-	-	-	-	-	-	-	-	Rotamase_2
TH2_k127_1083678_1	1042377.AFPJ01000054_gene1686	2.165e-248	782.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria,469KU@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
TH2_k127_1083678_0	247490.KSU1_C1442	1.161e-291	900.0	COG3119@1|root,COG3119@2|Bacteria,2IXNZ@203682|Planctomycetes	203682|Planctomycetes	P	PFAM sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
TH2_k127_1083678_4	211165.AJLN01000079_gene370	9.018e-136	445.0	COG1262@1|root,COG1262@2|Bacteria,1G4C8@1117|Cyanobacteria,1JJTS@1189|Stigonemataceae	1117|Cyanobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
TH2_k127_1083678_14	522306.CAP2UW1_1313	1.225e-30	128.0	COG4566@1|root,COG4566@2|Bacteria,1MZ8E@1224|Proteobacteria,2VYAI@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Pfam Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TH2_k127_1083678_13	522306.CAP2UW1_1311	8.049e-58	220.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,2VM61@28216|Betaproteobacteria,1KQQ2@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	K	PFAM regulatory protein LuxR	-	-	-	ko:K13041	ko02020,map02020	M00514	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
TH2_k127_1083678_3	240016.ABIZ01000001_gene131	3.629e-139	463.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_9
TH2_k127_1083678_10	240016.ABIZ01000001_gene2648	1.238e-85	299.0	COG0144@1|root,COG0144@2|Bacteria,46TY0@74201|Verrucomicrobia,2ITWQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	16S rRNA methyltransferase RsmB/F	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
TH2_k127_1083678_7	292459.STH1679	5.46e-101	364.0	COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,2493T@186801|Clostridia	186801|Clostridia	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
TH2_k127_1083678_16	1352941.M877_08590	3.188e-06	52.0	COG3209@1|root,COG3209@2|Bacteria,2GMBB@201174|Actinobacteria	201174|Actinobacteria	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	Endonuclea_NS_2,PT-HINT,RHS_repeat,TGFb_propeptide,Tox-REase-5
TH2_k127_1088472_3	497964.CfE428DRAFT_4766	1.03e-89	306.0	COG1039@1|root,COG1039@2|Bacteria,46UTB@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	-	-	3.1.26.4	ko:K03471	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
TH2_k127_1088472_9	344747.PM8797T_18429	1.094e-25	124.0	COG2304@1|root,COG2304@2|Bacteria,2IYB0@203682|Planctomycetes	203682|Planctomycetes	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1088472_10	497964.CfE428DRAFT_3424	8.63e-23	105.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	rtxA	GO:0000166,GO:0000287,GO:0000822,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0004175,GO:0004197,GO:0005488,GO:0005509,GO:0005524,GO:0005575,GO:0005576,GO:0006464,GO:0006508,GO:0006807,GO:0006996,GO:0007010,GO:0007015,GO:0008144,GO:0008150,GO:0008152,GO:0008154,GO:0008233,GO:0008234,GO:0009405,GO:0009987,GO:0010467,GO:0016043,GO:0016485,GO:0016540,GO:0016787,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018149,GO:0018153,GO:0018193,GO:0018199,GO:0018205,GO:0018262,GO:0018995,GO:0019538,GO:0019835,GO:0019836,GO:0020002,GO:0022411,GO:0030029,GO:0030036,GO:0030042,GO:0030554,GO:0031640,GO:0032553,GO:0032555,GO:0032559,GO:0032984,GO:0033643,GO:0033644,GO:0035639,GO:0035821,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043178,GO:0043412,GO:0043624,GO:0043657,GO:0043933,GO:0044003,GO:0044004,GO:0044179,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044279,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046872,GO:0051261,GO:0051604,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0070011,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0097435,GO:0140096,GO:1901265,GO:1901363,GO:1901564	-	ko:K10953,ko:K20276	ko02024,ko05110,map02024,map05110	-	-	-	ko00000,ko00001,ko02042	-	-	-	ACD,Hydrolase_4,MLD,Peptidase_C80,RtxA
TH2_k127_1088472_8	1504672.669785740	2.069e-28	117.0	COG2402@1|root,COG2402@2|Bacteria,1PZKR@1224|Proteobacteria,2W40N@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1088472_7	756272.Plabr_3241	2.852e-46	178.0	COG0657@1|root,COG0657@2|Bacteria,2IXCK@203682|Planctomycetes	203682|Planctomycetes	I	COG0657 Esterase lipase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,EF-hand_5,Peptidase_S9
TH2_k127_1088472_1	497964.CfE428DRAFT_3394	2.785e-129	422.0	COG0275@1|root,COG0275@2|Bacteria,46UK9@74201|Verrucomicrobia	74201|Verrucomicrobia	M	MraW methylase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_5
TH2_k127_1088472_0	1396418.BATQ01000049_gene415	1.75e-240	767.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TH2_k127_1088472_2	1041930.Mtc_0427	6.052e-108	389.0	arCOG02350@1|root,arCOG07605@1|root,arCOG02350@2157|Archaea,arCOG07605@2157|Archaea,2Y7PW@28890|Euryarchaeota	28890|Euryarchaeota	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9
TH2_k127_1088472_6	215803.DB30_6335	9.749e-57	206.0	COG0784@1|root,COG0784@2|Bacteria,1QUN7@1224|Proteobacteria,42VIG@68525|delta/epsilon subdivisions,2WS98@28221|Deltaproteobacteria,2YV93@29|Myxococcales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TH2_k127_1088472_4	1396418.BATQ01000049_gene411	1.144e-77	278.0	COG0745@1|root,COG2208@1|root,COG0745@2|Bacteria,COG2208@2|Bacteria,46U96@74201|Verrucomicrobia,2ITU0@203494|Verrucomicrobiae	203494|Verrucomicrobiae	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,SpoIIE
TH2_k127_1088472_5	506534.Rhein_0333	6.311e-74	257.0	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,1RM8D@1236|Gammaproteobacteria,1WWMY@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
TH2_k127_1121839_2	330214.NIDE3482	1.033e-153	488.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
TH2_k127_1121839_11	401053.AciPR4_1930	1.6e-24	103.0	COG4447@1|root,COG4447@2|Bacteria,3Y3TM@57723|Acidobacteria,2JHSZ@204432|Acidobacteriia	204432|Acidobacteriia	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
TH2_k127_1121839_6	420662.Mpe_A1857	8.756e-60	216.0	COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2VHCT@28216|Betaproteobacteria,1KJJV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	TatD related DNase	ycfH	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
TH2_k127_1121839_1	452637.Oter_1781	9.483e-179	565.0	COG1082@1|root,COG1082@2|Bacteria,46UVB@74201|Verrucomicrobia,3K7PN@414999|Opitutae	414999|Opitutae	G	AP endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
TH2_k127_1121839_10	1379698.RBG1_1C00001G0311	1.792e-32	130.0	COG0799@1|root,COG0799@2|Bacteria,2NPYI@2323|unclassified Bacteria	2|Bacteria	S	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113	2.7.7.18	ko:K00969,ko:K09710	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	RsfS
TH2_k127_1121839_9	862514.HMPREF0623_0153	2.263e-44	168.0	COG1057@1|root,COG1057@2|Bacteria,1V3SK@1239|Firmicutes,4HGXK@91061|Bacilli,3F4D6@33958|Lactobacillaceae	91061|Bacilli	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
TH2_k127_1121839_5	309801.trd_0595	1.048e-78	271.0	COG0157@1|root,COG0157@2|Bacteria,2G6GJ@200795|Chloroflexi,27Z0A@189775|Thermomicrobia	189775|Thermomicrobia	H	Quinolinate phosphoribosyl transferase, N-terminal domain	-	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
TH2_k127_1121839_13	866536.Belba_0871	2.417e-16	87.0	2EWFP@1|root,33PU3@2|Bacteria,4P0EJ@976|Bacteroidetes	976|Bacteroidetes	S	by Glimmer2	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1121839_8	300852.55772176	2.165e-48	198.0	COG1459@1|root,COG1459@2|Bacteria,1WIU3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	NU	PFAM Bacterial type II secretion system protein F domain	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
TH2_k127_1121839_3	1499967.BAYZ01000014_gene6369	3.364e-120	413.0	COG2804@1|root,COG2804@2|Bacteria,2NNNI@2323|unclassified Bacteria	2|Bacteria	NU	Type II secretion system (T2SS), protein E, N-terminal domain	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
TH2_k127_1121839_0	697281.Mahau_1823	3.773e-212	669.0	COG3119@1|root,COG3119@2|Bacteria,1TQD2@1239|Firmicutes,24A1P@186801|Clostridia,42HP1@68295|Thermoanaerobacterales	186801|Clostridia	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TH2_k127_1121839_12	56780.SYN_02258	1.014e-21	100.0	COG2204@1|root,COG2204@2|Bacteria,1QVAR@1224|Proteobacteria	1224|Proteobacteria	T	PFAM Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TH2_k127_1121839_7	215803.DB30_7213	5.268e-50	187.0	COG0300@1|root,COG0300@2|Bacteria,1RAFB@1224|Proteobacteria,43C29@68525|delta/epsilon subdivisions,2X7CU@28221|Deltaproteobacteria,2YV3W@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TH2_k127_1121839_4	240016.ABIZ01000001_gene994	3.348e-112	374.0	COG0523@1|root,COG0523@2|Bacteria,46URF@74201|Verrucomicrobia	74201|Verrucomicrobia	S	SRP54-type protein, GTPase domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
TH2_k127_1121839_15	448385.sce8467	9.802e-09	61.0	COG0021@1|root,COG0021@2|Bacteria,1QSQD@1224|Proteobacteria,439WJ@68525|delta/epsilon subdivisions,2X9PA@28221|Deltaproteobacteria,2YYQF@29|Myxococcales	28221|Deltaproteobacteria	H	Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
TH2_k127_113713_1	111781.Lepto7376_3027	1.2e-62	221.0	COG1262@1|root,COG4249@1|root,COG1262@2|Bacteria,COG4249@2|Bacteria,1G0ZT@1117|Cyanobacteria,1H9P9@1150|Oscillatoriales	1117|Cyanobacteria	M	Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,Peptidase_C14
TH2_k127_113713_3	1033743.CAES01000045_gene141	1.979e-18	91.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H,DUF4450,DUF608
TH2_k127_113713_0	1396141.BATP01000007_gene5788	2.693e-95	357.0	2DBSP@1|root,2ZAT9@2|Bacteria,46Z78@74201|Verrucomicrobia,2IWQF@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_113713_2	861299.J421_0351	1.729e-55	198.0	COG1129@1|root,COG1129@2|Bacteria,1ZVAU@142182|Gemmatimonadetes	2|Bacteria	G	ABC transporter	rbsA	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
TH2_k127_1152178_7	530564.Psta_3807	9.689e-40	154.0	COG3264@1|root,COG3264@2|Bacteria,2IY5W@203682|Planctomycetes	203682|Planctomycetes	M	COG3264 Small-conductance mechanosensitive channel	-	-	-	ko:K22051	-	-	-	-	ko00000,ko02000	1.A.23.1.2,1.A.23.1.3	-	-	MS_channel
TH2_k127_1152178_0	497964.CfE428DRAFT_4407	3.755e-184	584.0	COG0205@1|root,COG0205@2|Bacteria	2|Bacteria	G	6-phosphofructokinase activity	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
TH2_k127_1152178_5	686340.Metal_2200	2.23e-49	194.0	2C6BE@1|root,32XBJ@2|Bacteria,1NB89@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1152178_3	1304885.AUEY01000019_gene1167	1.288e-88	314.0	28HK0@1|root,2Z7V0@2|Bacteria,1MXSJ@1224|Proteobacteria,42P6V@68525|delta/epsilon subdivisions,2WM6M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4105)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4105
TH2_k127_1152178_2	909663.KI867149_gene3370	3.261e-118	403.0	COG1075@1|root,COG1075@2|Bacteria,1NYAK@1224|Proteobacteria,42Q3C@68525|delta/epsilon subdivisions,2WMAK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TH2_k127_1152178_6	1037409.BJ6T_58620	3.1e-49	188.0	COG1814@1|root,COG1814@2|Bacteria,1R469@1224|Proteobacteria,2U4KR@28211|Alphaproteobacteria,3JUX4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
TH2_k127_1152178_9	794903.OPIT5_01675	5.189e-16	87.0	2DE2A@1|root,2ZK73@2|Bacteria,46Y2T@74201|Verrucomicrobia,3K8UK@414999|Opitutae	414999|Opitutae	S	Protein of unknown function (DUF2959)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2959
TH2_k127_1152178_1	243233.MCA2756	1.661e-143	464.0	COG0438@1|root,COG0438@2|Bacteria,1NMB5@1224|Proteobacteria,1RRVU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Sulfotransfer_3
TH2_k127_1152178_4	243233.MCA2757	5.209e-62	226.0	COG0385@1|root,COG0385@2|Bacteria	2|Bacteria	S	bile acid:sodium symporter activity	-	-	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	-	SBF
TH2_k127_115244_11	1303518.CCALI_01058	9.891e-23	98.0	COG1522@1|root,COG1522@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	nirH	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_AsnC-type
TH2_k127_115244_0	1396141.BATP01000009_gene2660	1.884e-297	932.0	COG2183@1|root,COG2183@2|Bacteria,46TQH@74201|Verrucomicrobia,2ITYX@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Tex-like protein N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
TH2_k127_115244_2	1303518.CCALI_00869	3.527e-135	441.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	tas	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TH2_k127_115244_9	497964.CfE428DRAFT_3426	3.025e-28	123.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_5
TH2_k127_115244_4	240015.ACP_1013	3.265e-90	304.0	COG0623@1|root,COG0623@2|Bacteria,3Y3EN@57723|Acidobacteria,2JHZZ@204432|Acidobacteriia	204432|Acidobacteriia	I	Enoyl- acyl-carrier-protein reductase NADH	-	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TH2_k127_115244_12	326427.Cagg_2320	1.415e-19	91.0	COG1550@1|root,COG1550@2|Bacteria,2G765@200795|Chloroflexi,375YB@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function (DUF503)	-	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
TH2_k127_115244_3	760011.Spico_0633	1.138e-97	335.0	COG2204@1|root,COG2204@2|Bacteria,2J5NY@203691|Spirochaetes	203691|Spirochaetes	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	rrp-2	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH2_k127_115244_6	794903.OPIT5_27960	1.661e-58	217.0	COG0860@1|root,COG0860@2|Bacteria,46SS7@74201|Verrucomicrobia,3K7YX@414999|Opitutae	414999|Opitutae	M	cell wall hydrolase	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3
TH2_k127_115244_13	1379698.RBG1_1C00001G1111	3.581e-13	82.0	COG3203@1|root,COG3203@2|Bacteria	2|Bacteria	M	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp,BBP2,Porin_2,Porin_4
TH2_k127_115244_1	497964.CfE428DRAFT_4597	1.074e-248	777.0	COG4108@1|root,COG4108@2|Bacteria,46SF9@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
TH2_k127_115244_8	309799.DICTH_1469	8.228e-56	205.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	yfhR3	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Hydrolase_4,Peptidase_S9
TH2_k127_115244_7	641491.DND132_2105	1.857e-57	207.0	28NM7@1|root,2ZBMT@2|Bacteria,1R9Y9@1224|Proteobacteria,42RRM@68525|delta/epsilon subdivisions,2WNWI@28221|Deltaproteobacteria,2MBBB@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF2959)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2959
TH2_k127_115244_5	1353531.AZNX01000005_gene3394	3.702e-71	249.0	COG0413@1|root,COG0413@2|Bacteria,1RFYM@1224|Proteobacteria,2U7V2@28211|Alphaproteobacteria,4BAR4@82115|Rhizobiaceae	28211|Alphaproteobacteria	H	Ketopantoate hydroxymethyltransferase	-	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
TH2_k127_115244_10	1121382.JQKG01000081_gene879	4.124e-23	101.0	COG2949@1|root,COG2949@2|Bacteria	2|Bacteria	S	response to drug	sanA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0042221,GO:0042493,GO:0044425,GO:0044464,GO:0050896,GO:0071944	-	ko:K03748	-	-	-	-	ko00000	-	-	-	DUF218
TH2_k127_1156488_0	1396418.BATQ01000009_gene3834	1.726e-169	546.0	COG0514@1|root,COG0514@2|Bacteria,46U82@74201|Verrucomicrobia,2ITT4@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	RQC	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
TH2_k127_1156488_8	1236959.BAMT01000008_gene2456	3.902e-07	63.0	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,2VI5J@28216|Betaproteobacteria,2KMI1@206350|Nitrosomonadales	206350|Nitrosomonadales	M	PFAM AsmA family	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
TH2_k127_1156488_9	1307759.JOMJ01000004_gene2678	1.565e-06	61.0	COG2982@1|root,COG2982@2|Bacteria,1QA6E@1224|Proteobacteria,42PKZ@68525|delta/epsilon subdivisions,2WIQZ@28221|Deltaproteobacteria,2MACK@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	AsmA-like C-terminal region	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
TH2_k127_1156488_1	478741.JAFS01000001_gene1574	1.237e-68	243.0	COG1597@1|root,COG1597@2|Bacteria,46SR5@74201|Verrucomicrobia,37G0D@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	G	Diacylglycerol kinase catalytic domain (presumed)	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
TH2_k127_1156488_5	794903.OPIT5_25050	8.934e-35	147.0	COG0457@1|root,COG1729@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,46VEZ@74201|Verrucomicrobia,3K7DT@414999|Opitutae	414999|Opitutae	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_6
TH2_k127_1156488_6	452637.Oter_0430	6.959e-26	117.0	COG3437@1|root,COG3437@2|Bacteria,46UU1@74201|Verrucomicrobia	74201|Verrucomicrobia	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_5,Response_reg
TH2_k127_1156488_7	452637.Oter_0441	6.024e-18	89.0	COG1516@1|root,COG1516@2|Bacteria,46WPJ@74201|Verrucomicrobia,3K8AQ@414999|Opitutae	414999|Opitutae	N	Flagellar protein FliS	-	-	-	ko:K02422	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliS
TH2_k127_1156488_2	1307759.JOMJ01000004_gene2828	5.358e-62	224.0	2C8XG@1|root,2Z7PK@2|Bacteria,1RA5I@1224|Proteobacteria,42QRD@68525|delta/epsilon subdivisions,2WMYW@28221|Deltaproteobacteria,2MC9C@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF4197)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4197
TH2_k127_1156488_4	497964.CfE428DRAFT_3867	4.828e-35	136.0	COG1977@1|root,COG1977@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	-	-	2.7.7.80,2.8.1.11	ko:K03636,ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiS
TH2_k127_1156488_3	497964.CfE428DRAFT_3868	1.866e-45	164.0	COG4447@1|root,COG4447@2|Bacteria,46VQN@74201|Verrucomicrobia	74201|Verrucomicrobia	G	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
TH2_k127_1163038_1	1121920.AUAU01000008_gene1626	1.193e-42	168.0	COG2197@1|root,COG2197@2|Bacteria,3Y7XN@57723|Acidobacteria	57723|Acidobacteria	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TH2_k127_1163038_2	1218076.BAYB01000013_gene2775	4.694e-30	138.0	COG2199@1|root,COG4585@1|root,COG3706@2|Bacteria,COG4585@2|Bacteria,1R7HC@1224|Proteobacteria	1224|Proteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GGDEF,HATPase_c,HWE_HK,HisKA,MASE1,PAS,PAS_3,PAS_4,PAS_9,Reg_prop,Response_reg,Y_Y_Y,dCache_1
TH2_k127_1163038_0	252305.OB2597_13088	9.58e-61	234.0	COG0642@1|root,COG0784@1|root,COG3355@1|root,COG3920@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3355@2|Bacteria,COG3920@2|Bacteria,1NRP8@1224|Proteobacteria,2TWME@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HWE_HK,HisKA,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1
TH2_k127_1183094_1	1379270.AUXF01000001_gene2467	5.534e-97	333.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1ZT1A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Enoyl-CoA hydratase/isomerase	fadJ	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
TH2_k127_1183094_0	497964.CfE428DRAFT_5145	3.211e-147	477.0	COG0183@1|root,COG0183@2|Bacteria	2|Bacteria	I	Belongs to the thiolase family	fadA	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TH2_k127_1183094_4	1137271.AZUM01000001_gene1531	2.171e-10	64.0	2DSMH@1|root,33GPM@2|Bacteria,2GR8G@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1183094_3	1283300.ATXB01000001_gene300	5.364e-45	167.0	COG1848@1|root,COG1848@2|Bacteria,1RK9K@1224|Proteobacteria,1SBYF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TH2_k127_1183094_2	497964.CfE428DRAFT_6618	7.639e-73	247.0	COG0519@1|root,COG0519@2|Bacteria,46SIW@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
TH2_k127_1188064_9	1189620.AJXL01000040_gene539	1.245e-27	123.0	COG3209@1|root,COG3405@1|root,COG3209@2|Bacteria,COG3405@2|Bacteria,4PKBQ@976|Bacteroidetes,1IJ7S@117743|Flavobacteriia,2NT9A@237|Flavobacterium	976|Bacteroidetes	M	SPTR CHU large protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF5011,HYR,SprB
TH2_k127_1188064_7	530564.Psta_2788	2.485e-50	198.0	COG1657@1|root,COG1657@2|Bacteria	2|Bacteria	I	PFAM Prenyltransferase squalene oxidase	-	-	3.1.3.1,3.1.3.5,3.6.1.45	ko:K01077,ko:K11751	ko00230,ko00240,ko00730,ko00760,ko00790,ko01100,ko01110,ko02020,map00230,map00240,map00730,map00760,map00790,map01100,map01110,map02020	M00126	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02135,R02323,R02719,R03346,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Big_2,Cadherin-like,Cu_amine_oxidN1,DUF4430,FIVAR,Flg_new,Prenyltrans,SLH
TH2_k127_1188064_12	530564.Psta_2790	1.514e-08	63.0	COG0848@1|root,COG0848@2|Bacteria,2J3NN@203682|Planctomycetes	203682|Planctomycetes	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
TH2_k127_1188064_13	518766.Rmar_1719	6.982e-07	56.0	COG0848@1|root,COG0848@2|Bacteria,4NHYQ@976|Bacteroidetes,1FJBN@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	U	Biopolymer transport protein ExbD/TolR	-	-	-	-	-	-	-	-	-	-	-	-	ExbD
TH2_k127_1188064_10	1191523.MROS_2571	5.965e-24	110.0	COG0811@1|root,COG0811@2|Bacteria	2|Bacteria	U	bacteriocin transport	exbB	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
TH2_k127_1188064_1	1123508.JH636441_gene3210	2.326e-128	467.0	COG1729@1|root,COG1729@2|Bacteria,2J28G@203682|Planctomycetes	203682|Planctomycetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_6
TH2_k127_1188064_4	530564.Psta_2794	3.463e-81	299.0	COG0457@1|root,COG0457@2|Bacteria,2J2QX@203682|Planctomycetes	203682|Planctomycetes	S	Outer membrane lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_6
TH2_k127_1188064_11	530564.Psta_2787	8.746e-14	85.0	COG0457@1|root,COG0457@2|Bacteria,2J21N@203682|Planctomycetes	203682|Planctomycetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_6,TPR_7
TH2_k127_1188064_3	497964.CfE428DRAFT_2718	1.498e-99	333.0	COG0142@1|root,COG0142@2|Bacteria,46S62@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
TH2_k127_1188064_0	497964.CfE428DRAFT_1708	3.408e-173	551.0	COG0527@1|root,COG0527@2|Bacteria,46SIS@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Amino acid kinase family	lysC	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
TH2_k127_1188064_8	237368.SCABRO_03600	2.67e-43	165.0	28JE3@1|root,2Z98B@2|Bacteria,2J0PD@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1188064_14	521674.Plim_1219	0.0009721	46.0	2EJ1R@1|root,33CSX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1188064_2	497964.CfE428DRAFT_1699	2.505e-128	424.0	COG0460@1|root,COG0460@2|Bacteria,46SIY@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Homoserine dehydrogenase	thrA	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
TH2_k127_1188064_5	264732.Moth_0883	5.069e-61	217.0	COG0284@1|root,COG0284@2|Bacteria,1TPPH@1239|Firmicutes,24DII@186801|Clostridia,42G12@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
TH2_k127_1188064_6	401526.TcarDRAFT_1408	1.768e-57	211.0	COG1947@1|root,COG1947@2|Bacteria,1TPXV@1239|Firmicutes,4H1VY@909932|Negativicutes	909932|Negativicutes	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
TH2_k127_1194114_0	452637.Oter_2109	8.305e-124	405.0	COG0180@1|root,COG0180@2|Bacteria,46SA6@74201|Verrucomicrobia,3K7UW@414999|Opitutae	414999|Opitutae	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
TH2_k127_1194114_1	497964.CfE428DRAFT_2037	3.562e-16	80.0	COG0161@1|root,COG0161@2|Bacteria,46SBR@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Aminotransferase class-III	-	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TH2_k127_1195650_0	382464.ABSI01000005_gene1355	6.862e-266	842.0	COG0556@1|root,COG0556@2|Bacteria,46SF2@74201|Verrucomicrobia,2ITYA@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
TH2_k127_1201610_2	589865.DaAHT2_1112	4.764e-179	574.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria,2MI87@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Acetyl-CoA hydrolase transferase	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1,Acetyltransf_3
TH2_k127_1201610_0	589865.DaAHT2_1111	6.158e-268	843.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2MIWX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM CoA-binding domain protein	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
TH2_k127_1201610_8	1499967.BAYZ01000065_gene6110	4.546e-59	216.0	COG1238@1|root,COG1238@2|Bacteria,2NR6R@2323|unclassified Bacteria	2|Bacteria	S	SNARE associated Golgi protein	MA20_20865	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	SNARE_assoc
TH2_k127_1201610_9	1131269.AQVV01000044_gene1784	6.882e-32	142.0	2FEYA@1|root,346X0@2|Bacteria	1131269.AQVV01000044_gene1784|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1201610_10	1396141.BATP01000005_gene6100	1.38e-15	90.0	COG0526@1|root,COG0526@2|Bacteria,46XMX@74201|Verrucomicrobia,2IW7U@203494|Verrucomicrobiae	203494|Verrucomicrobiae	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1201610_7	349741.Amuc_1987	1.661e-107	359.0	COG1657@1|root,COG1657@2|Bacteria,46UYQ@74201|Verrucomicrobia,2ITJS@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1201610_3	497964.CfE428DRAFT_2750	7.346e-152	517.0	COG1196@1|root,COG1196@2|Bacteria,46TP5@74201|Verrucomicrobia	74201|Verrucomicrobia	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1201610_1	497964.CfE428DRAFT_2752	1.512e-223	716.0	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,46TJC@74201|Verrucomicrobia	74201|Verrucomicrobia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1201610_5	497964.CfE428DRAFT_2753	2.076e-123	421.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	BatA,CARDB,DUF3367,DUF4091,DUF4159
TH2_k127_1201610_6	886293.Sinac_3485	7.795e-108	357.0	COG1721@1|root,COG1721@2|Bacteria,2IYDF@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
TH2_k127_1201610_4	349741.Amuc_2119	3.685e-149	479.0	COG0714@1|root,COG0714@2|Bacteria,46TCY@74201|Verrucomicrobia,2ITSU@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TH2_k127_1202528_1	1304872.JAGC01000003_gene2706	4.541e-29	121.0	COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,42MIR@68525|delta/epsilon subdivisions,2WJ85@28221|Deltaproteobacteria,2M8UI@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM membrane bound O-acyl transferase MBOAT	-	-	-	ko:K19294	-	-	-	-	ko00000	-	-	-	MBOAT
TH2_k127_1202528_0	1121403.AUCV01000020_gene3101	5.051e-50	192.0	COG0457@1|root,COG0457@2|Bacteria,1RIYN@1224|Proteobacteria,42T31@68525|delta/epsilon subdivisions,2WPYY@28221|Deltaproteobacteria,2MKKV@213118|Desulfobacterales	28221|Deltaproteobacteria	S	SGNH hydrolase-like domain, acetyltransferase AlgX	-	-	-	-	-	-	-	-	-	-	-	-	ALGX
TH2_k127_1202528_2	1304865.JAGF01000001_gene266	7.668e-16	92.0	COG3209@1|root,COG3209@2|Bacteria,2GMBB@201174|Actinobacteria	201174|Actinobacteria	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	PT-HINT,RHS_repeat
TH2_k127_1210319_0	697281.Mahau_0028	2.648e-106	355.0	COG0407@1|root,COG0407@2|Bacteria,1V5JE@1239|Firmicutes,24E5A@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
TH2_k127_1210319_1	452637.Oter_4548	1.462e-39	155.0	COG1993@1|root,COG1993@2|Bacteria,46VZM@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
TH2_k127_1210319_2	1150469.RSPPHO_00346	3.105e-28	117.0	COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,2UBUP@28211|Alphaproteobacteria,2JT48@204441|Rhodospirillales	204441|Rhodospirillales	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
TH2_k127_1231134_0	1313421.JHBV01000041_gene3629	3.167e-180	590.0	COG2304@1|root,COG2304@2|Bacteria,4NK2W@976|Bacteroidetes	976|Bacteroidetes	M	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	OmpA,VIT,VWA,VWA_3
TH2_k127_1231134_11	1168289.AJKI01000011_gene567	3.249e-09	68.0	COG5295@1|root,COG5295@2|Bacteria,4NV9S@976|Bacteroidetes,2FYT9@200643|Bacteroidia	976|Bacteroidetes	UW	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1566
TH2_k127_1231134_3	1210884.HG799465_gene11872	9.305e-88	302.0	COG2304@1|root,COG2304@2|Bacteria,2IYXD@203682|Planctomycetes	203682|Planctomycetes	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA
TH2_k127_1231134_7	767029.HMPREF9154_1014	3.791e-19	99.0	COG1073@1|root,COG1073@2|Bacteria,2I9HJ@201174|Actinobacteria,4DSUU@85009|Propionibacteriales	201174|Actinobacteria	S	Serine aminopeptidase, S33	-	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0009605,GO:0009607,GO:0030312,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0071944,GO:0075136	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
TH2_k127_1231134_1	452637.Oter_0444	1.182e-91	327.0	COG1345@1|root,COG1345@2|Bacteria,46U2K@74201|Verrucomicrobia,3K76A@414999|Opitutae	414999|Opitutae	N	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end	-	-	-	ko:K02407	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_IN,FliD_C,FliD_N
TH2_k127_1231134_6	452637.Oter_0443	5.397e-25	114.0	2EI2N@1|root,33BU2@2|Bacteria,46WEF@74201|Verrucomicrobia,3K8D4@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1231134_9	1395587.P364_0129535	7.055e-14	76.0	COG0745@1|root,COG0745@2|Bacteria,1TRS2@1239|Firmicutes,4HU4V@91061|Bacilli,26S3N@186822|Paenibacillaceae	91061|Bacilli	T	PhoP family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TH2_k127_1231134_5	452637.Oter_0650	6.085e-27	126.0	COG4726@1|root,COG4726@2|Bacteria,46YMK@74201|Verrucomicrobia,3K9UG@414999|Opitutae	414999|Opitutae	NU	Pilus assembly protein PilX	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1231134_2	497964.CfE428DRAFT_3562	1.299e-90	312.0	COG1459@1|root,COG1459@2|Bacteria,46S5B@74201|Verrucomicrobia	74201|Verrucomicrobia	U	PFAM type II secretion system	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
TH2_k127_1231134_10	1380394.JADL01000001_gene2364	9.761e-11	68.0	COG2199@1|root,COG4191@1|root,COG3706@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2JW7Q@204441|Rhodospirillales	204441|Rhodospirillales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
TH2_k127_1231134_4	880072.Desac_0865	6.072e-54	215.0	COG2202@1|root,COG4585@1|root,COG2202@2|Bacteria,COG4585@2|Bacteria,1RB4Z@1224|Proteobacteria,42SHV@68525|delta/epsilon subdivisions,2X7QP@28221|Deltaproteobacteria,2MRJP@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,PAS_9
TH2_k127_1231134_8	1054213.HMPREF9946_03239	2.14e-18	87.0	COG2197@1|root,COG2197@2|Bacteria,1R9GN@1224|Proteobacteria,2VETM@28211|Alphaproteobacteria,2JYMX@204441|Rhodospirillales	204441|Rhodospirillales	K	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TH2_k127_1243262_0	1142394.PSMK_27880	3.321e-44	173.0	COG2017@1|root,COG2017@2|Bacteria,2J49D@203682|Planctomycetes	203682|Planctomycetes	G	converts alpha-aldose to the beta-anomer	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1243262_1	497964.CfE428DRAFT_2566	3.132e-43	161.0	COG2967@1|root,COG2967@2|Bacteria,46T44@74201|Verrucomicrobia	74201|Verrucomicrobia	P	ApaG domain	-	-	-	ko:K06195	-	-	-	-	ko00000	-	-	-	DUF525
TH2_k127_1273618_6	1280950.HJO_01975	8.291e-06	56.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	ko:K02674,ko:K07114	-	-	-	-	ko00000,ko02000,ko02035,ko02044	1.A.13.2.2,1.A.13.2.3	-	-	Dockerin_1,Lipase_GDSL_2,Neisseria_PilC,VWA,VWA_2,VWA_3
TH2_k127_1273618_0	794903.OPIT5_05790	7.788e-216	684.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2,OmpA
TH2_k127_1273618_5	1499967.BAYZ01000022_gene216	5.574e-09	58.0	COG1070@1|root,COG1070@2|Bacteria	2|Bacteria	G	xylulokinase activity	ygcE	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
TH2_k127_1273618_4	868131.MSWAN_2148	4.443e-36	139.0	COG1917@1|root,arCOG03004@2157|Archaea,2XYUR@28890|Euryarchaeota,23P5U@183925|Methanobacteria	183925|Methanobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TH2_k127_1273618_2	264732.Moth_0912	1.514e-46	177.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,42EW8@68295|Thermoanaerobacterales	186801|Clostridia	KLT	Serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
TH2_k127_1273618_3	237368.SCABRO_01481	1.625e-44	173.0	COG1376@1|root,COG1376@2|Bacteria,2J0C4@203682|Planctomycetes	203682|Planctomycetes	M	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	LysM,YkuD
TH2_k127_1273618_1	1396141.BATP01000006_gene5499	3.169e-130	424.0	COG0825@1|root,COG0825@2|Bacteria,46SE1@74201|Verrucomicrobia,2IU0V@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit	-	-	-	-	-	-	-	-	-	-	-	-	ACCA
TH2_k127_1276649_4	720554.Clocl_2731	2.352e-62	220.0	COG1606@1|root,COG1606@2|Bacteria,1TPB2@1239|Firmicutes,2485J@186801|Clostridia,3WI5Y@541000|Ruminococcaceae	186801|Clostridia	S	TIGR00268 family	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	ATP_bind_3,NAD_synthase,QueC
TH2_k127_1276649_1	497964.CfE428DRAFT_0655	3.417e-107	371.0	COG2022@1|root,COG2022@2|Bacteria,46SHY@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG
TH2_k127_1276649_7	1210884.HG799462_gene7973	7.289e-33	145.0	COG1595@1|root,COG1595@2|Bacteria,2IZ6J@203682|Planctomycetes	203682|Planctomycetes	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TH2_k127_1276649_6	497964.CfE428DRAFT_2117	1.55e-52	209.0	COG0681@1|root,COG0681@2|Bacteria,46SR0@74201|Verrucomicrobia	74201|Verrucomicrobia	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
TH2_k127_1276649_0	240016.ABIZ01000001_gene2020	1.204e-263	823.0	COG0481@1|root,COG0481@2|Bacteria,46SA7@74201|Verrucomicrobia,2IU2I@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
TH2_k127_1276649_5	1250278.JQNQ01000001_gene519	1.634e-54	207.0	COG1253@1|root,COG1253@2|Bacteria,4NE7C@976|Bacteroidetes,1HYD7@117743|Flavobacteriia	976|Bacteroidetes	S	COGs COG1253 Hemolysins and related protein containing CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS,DUF21
TH2_k127_1276649_2	525904.Tter_2212	9.477e-101	343.0	COG0399@1|root,COG0399@2|Bacteria,2NQH7@2323|unclassified Bacteria	2|Bacteria	E	Cys/Met metabolism PLP-dependent enzyme	stsA	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0016051,GO:0043170,GO:0044238,GO:0071704,GO:1901576	2.6.1.109	ko:K19715	-	-	R11395	RC00160	ko00000,ko01000,ko01005	-	-	-	DegT_DnrJ_EryC1
TH2_k127_1276649_8	1125863.JAFN01000001_gene3181	1.781e-22	101.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,42V0K@68525|delta/epsilon subdivisions,2WQ3M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	cold-shock protein	cspD	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TH2_k127_1276649_3	1291050.JAGE01000001_gene659	2.627e-74	259.0	COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,2488G@186801|Clostridia,3WG99@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
TH2_k127_1277844_0	639282.DEFDS_0642	4.872e-128	425.0	COG0318@1|root,COG0318@2|Bacteria,2GETC@200930|Deferribacteres	200930|Deferribacteres	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
TH2_k127_1277844_1	555079.Toce_0023	8.355e-69	243.0	COG0313@1|root,COG0313@2|Bacteria,1TP6U@1239|Firmicutes,24864@186801|Clostridia,42F0X@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
TH2_k127_1277844_2	234267.Acid_0104	8.285e-40	170.0	COG0457@1|root,COG0457@2|Bacteria,3Y3RA@57723|Acidobacteria	57723|Acidobacteria	M	SMART Tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8
TH2_k127_128936_2	1120973.AQXL01000133_gene1815	6.667e-200	636.0	COG1866@1|root,COG1866@2|Bacteria,1TPQV@1239|Firmicutes,4HAKG@91061|Bacilli,277V5@186823|Alicyclobacillaceae	91061|Bacilli	C	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	GO:0000166,GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0017076,GO:0019318,GO:0019319,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS09060,iYO844.BSU30560	PEPCK_ATP
TH2_k127_128936_3	1502851.FG93_05058	1.101e-153	511.0	COG0421@1|root,COG0421@2|Bacteria,1PD54@1224|Proteobacteria,2V9CT@28211|Alphaproteobacteria,3JYAK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Spermine/spermidine synthase domain	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
TH2_k127_128936_5	1396141.BATP01000002_gene4806	9.997e-73	251.0	COG0800@1|root,COG0800@2|Bacteria,46V7J@74201|Verrucomicrobia,2IU9V@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	KDPG and KHG aldolase	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase
TH2_k127_128936_1	1123278.KB893542_gene5513	2.018e-217	681.0	COG4225@1|root,COG4225@2|Bacteria,4NJYK@976|Bacteroidetes,47MFS@768503|Cytophagia	976|Bacteroidetes	S	Glycosyl Hydrolase Family 88	-	-	3.2.1.180	ko:K18581	-	-	R10867	RC00049,RC02427	ko00000,ko01000	-	GH88	-	Glyco_hydro_88
TH2_k127_128936_7	452637.Oter_1577	2.257e-29	122.0	COG1762@1|root,COG1762@2|Bacteria,46T7G@74201|Verrucomicrobia,3K85K@414999|Opitutae	414999|Opitutae	G	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
TH2_k127_128936_6	497964.CfE428DRAFT_5377	2.321e-64	232.0	COG0061@1|root,COG0061@2|Bacteria,46SUQ@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like,NAD_kinase
TH2_k127_128936_4	667014.Thein_0763	5.469e-77	268.0	COG1189@1|root,COG1189@2|Bacteria,2GGSK@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	FtsJ-like methyltransferase	-	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
TH2_k127_128936_0	382464.ABSI01000006_gene892	3.025e-223	709.0	COG1154@1|root,COG1154@2|Bacteria,46SAU@74201|Verrucomicrobia,2ITIS@203494|Verrucomicrobiae	203494|Verrucomicrobiae	HI	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
TH2_k127_128936_8	933262.AXAM01000004_gene2407	3.85e-13	76.0	COG1722@1|root,COG1722@2|Bacteria,1Q1MM@1224|Proteobacteria,42X37@68525|delta/epsilon subdivisions,2WSNI@28221|Deltaproteobacteria,2MKWN@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
TH2_k127_1294916_13	530564.Psta_3302	5.545e-07	54.0	COG2067@1|root,COG2067@2|Bacteria,2IZ1Q@203682|Planctomycetes	203682|Planctomycetes	I	Putative beta-barrel porin-2, OmpL-like. bbp2	-	-	-	-	-	-	-	-	-	-	-	-	BBP2
TH2_k127_1294916_5	452637.Oter_0427	3.471e-23	103.0	COG1815@1|root,COG1815@2|Bacteria,46WGM@74201|Verrucomicrobia,3K89P@414999|Opitutae	414999|Opitutae	N	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body	-	-	-	ko:K02387	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod
TH2_k127_1294916_4	278957.ABEA03000189_gene992	1.179e-36	143.0	COG1558@1|root,COG1558@2|Bacteria,46VMA@74201|Verrucomicrobia,3K86M@414999|Opitutae	414999|Opitutae	N	Belongs to the flagella basal body rod proteins family	-	-	-	ko:K02388	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
TH2_k127_1294916_10	452637.Oter_0425	5.289e-13	74.0	COG1677@1|root,COG1677@2|Bacteria,46WQE@74201|Verrucomicrobia,3K8GA@414999|Opitutae	414999|Opitutae	N	Flagellar hook-basal body complex protein FliE	fliE	-	-	ko:K02408	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliE
TH2_k127_1294916_1	278957.ABEA03000189_gene990	5.001e-120	403.0	COG1766@1|root,COG1766@2|Bacteria,46UUW@74201|Verrucomicrobia,3K76G@414999|Opitutae	414999|Opitutae	N	The M ring may be actively involved in energy transduction	-	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
TH2_k127_1294916_2	452637.Oter_0423	9.953e-68	243.0	COG1536@1|root,COG1536@2|Bacteria,46US0@74201|Verrucomicrobia,3K7R6@414999|Opitutae	414999|Opitutae	N	FliG middle domain	-	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
TH2_k127_1294916_11	401526.TcarDRAFT_2139	9.177e-09	67.0	COG1317@1|root,COG1317@2|Bacteria,1VEUV@1239|Firmicutes,4H4F2@909932|Negativicutes	909932|Negativicutes	N	flagellar assembly protein FliH	fliH	-	-	ko:K02411	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliH
TH2_k127_1294916_0	278957.ABEA03000189_gene987	2.43e-157	511.0	COG1157@1|root,COG1157@2|Bacteria,46UKN@74201|Verrucomicrobia,3K7FP@414999|Opitutae	414999|Opitutae	N	ATP synthase alpha/beta family, beta-barrel domain	-	-	3.6.3.14	ko:K02412	ko02040,map02040	-	-	-	ko00000,ko00001,ko01000,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	ATP-synt_ab,ATP-synt_ab_N
TH2_k127_1294916_9	382464.ABSI01000016_gene700	1.772e-16	88.0	COG3334@1|root,COG3334@2|Bacteria,46WC3@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM MgtE intracellular	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1294916_7	452637.Oter_0415	1.321e-20	98.0	COG1843@1|root,COG1843@2|Bacteria,46WH1@74201|Verrucomicrobia,3K8CY@414999|Opitutae	414999|Opitutae	N	Flagellar hook capping protein - N-terminal region	-	-	-	ko:K02389	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgD
TH2_k127_1294916_3	1408424.JHYI01000001_gene1988	8.865e-56	206.0	COG4786@1|root,COG4786@2|Bacteria,1TRA2@1239|Firmicutes,4HBNB@91061|Bacilli,1ZCVW@1386|Bacillus	91061|Bacilli	N	Flagellar basal body rod	flgG	GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
TH2_k127_1294916_6	452637.Oter_0413	3.688e-23	107.0	COG1580@1|root,COG1580@2|Bacteria,46W5Y@74201|Verrucomicrobia,3K86H@414999|Opitutae	414999|Opitutae	N	Controls the rotational direction of flagella during chemotaxis	-	-	-	ko:K02415	-	-	-	-	ko00000,ko02035	-	-	-	FliL
TH2_k127_1294916_8	511680.BUTYVIB_01868	1.159e-16	94.0	COG1868@1|root,COG1868@2|Bacteria,1TPTM@1239|Firmicutes,24AGV@186801|Clostridia,4BW3E@830|Butyrivibrio	186801|Clostridia	N	Flagellar motor switch protein FliM	fliM	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
TH2_k127_1294916_12	666686.B1NLA3E_18265	2.157e-07	54.0	COG1776@1|root,COG1886@1|root,COG1776@2|Bacteria,COG1886@2|Bacteria,1TPT8@1239|Firmicutes,4HC56@91061|Bacilli,1ZB7S@1386|Bacillus	91061|Bacilli	N	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliY	GO:0003674,GO:0003824,GO:0004721,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006935,GO:0008150,GO:0008152,GO:0009605,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0032879,GO:0036211,GO:0040011,GO:0040012,GO:0042221,GO:0042330,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0050896,GO:0051270,GO:0065007,GO:0071704,GO:0140096,GO:1901564,GO:1902021,GO:2000145	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	CheC,FliMN_C
TH2_k127_1311353_2	1232410.KI421426_gene1467	2.486e-11	66.0	2E5SP@1|root,330H2@2|Bacteria,1NDBY@1224|Proteobacteria	1224|Proteobacteria	S	YMGG-like Gly-zipper	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_OmpA,Gly-zipper_YMGG
TH2_k127_1311353_0	83406.HDN1F_04770	2.264e-228	732.0	28HUW@1|root,2Z81F@2|Bacteria,1Q3QA@1224|Proteobacteria,1RPFU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1311353_1	926569.ANT_25450	3.265e-42	158.0	COG2896@1|root,COG2896@2|Bacteria,2G5JT@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
TH2_k127_1313811_10	395493.BegalDRAFT_1262	1.59e-27	116.0	COG5316@1|root,COG5316@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
TH2_k127_1313811_4	395493.BegalDRAFT_1262	2.838e-101	346.0	COG5316@1|root,COG5316@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
TH2_k127_1313811_6	395493.BegalDRAFT_1263	1.441e-79	282.0	COG5316@1|root,COG5316@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
TH2_k127_1313811_12	326427.Cagg_1633	6.29e-10	74.0	COG1716@1|root,COG1716@2|Bacteria,2G79K@200795|Chloroflexi,37509@32061|Chloroflexia	32061|Chloroflexia	T	PFAM Forkhead-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3662,FHA
TH2_k127_1313811_9	478741.JAFS01000002_gene528	2.467e-31	130.0	COG0741@1|root,COG0741@2|Bacteria,46W79@74201|Verrucomicrobia,37GKP@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	Transglycosylase SLT domain	mltE	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT
TH2_k127_1313811_7	1499967.BAYZ01000118_gene3301	6.428e-43	160.0	COG1359@1|root,COG1359@2|Bacteria	2|Bacteria	S	Antibiotic biosynthesis monooxygenase	lsrG	-	5.3.1.32	ko:K11530	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000	-	-	-	ABM
TH2_k127_1313811_5	1142394.PSMK_10090	7.732e-91	318.0	COG2211@1|root,COG2211@2|Bacteria,2J14R@203682|Planctomycetes	203682|Planctomycetes	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TH2_k127_1313811_8	497964.CfE428DRAFT_3025	2.061e-42	172.0	COG0500@1|root,COG0500@2|Bacteria,46SYP@74201|Verrucomicrobia	74201|Verrucomicrobia	Q	Thiopurine S-methyltransferase (TPMT)	-	-	-	-	-	-	-	-	-	-	-	-	TPMT
TH2_k127_1313811_13	143224.JQMD01000002_gene2909	0.0008709	49.0	COG1286@1|root,COG1286@2|Bacteria,4NRG9@976|Bacteroidetes,1I2B6@117743|Flavobacteriia	976|Bacteroidetes	S	Colicin V production protein	cvpA	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
TH2_k127_1313811_3	497964.CfE428DRAFT_1568	5.784e-124	420.0	COG0358@1|root,COG0358@2|Bacteria,46S6C@74201|Verrucomicrobia	74201|Verrucomicrobia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_N,zf-CHC2
TH2_k127_1313811_0	497964.CfE428DRAFT_1569	5.779e-208	662.0	COG0568@1|root,COG0568@2|Bacteria,46S6M@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TH2_k127_1313811_1	589865.DaAHT2_1636	6.632e-175	562.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,42MDB@68525|delta/epsilon subdivisions,2WITV@28221|Deltaproteobacteria,2MI1E@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
TH2_k127_1313811_2	794903.OPIT5_07835	6.506e-141	456.0	COG0150@1|root,COG0150@2|Bacteria,46SJ4@74201|Verrucomicrobia,3K7F8@414999|Opitutae	414999|Opitutae	F	AIR synthase related protein, C-terminal domain	-	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
TH2_k127_1313811_11	1379270.AUXF01000001_gene2498	2.364e-20	105.0	COG0412@1|root,COG0412@2|Bacteria	2|Bacteria	Q	carboxymethylenebutenolidase activity	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
TH2_k127_1314934_6	338966.Ppro_0416	0.0001499	45.0	COG0025@1|root,COG0025@2|Bacteria,1QTUE@1224|Proteobacteria,43CF5@68525|delta/epsilon subdivisions,2WMDP@28221|Deltaproteobacteria,43U0N@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
TH2_k127_1314934_4	386456.JQKN01000006_gene1261	1.425e-57	213.0	COG3177@1|root,arCOG03110@2157|Archaea,2XUN8@28890|Euryarchaeota,23PGE@183925|Methanobacteria	183925|Methanobacteria	K	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic,HTH_24
TH2_k127_1314934_0	1396141.BATP01000003_gene5222	0.0	1493.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
TH2_k127_1314934_3	1403819.BATR01000067_gene2010	3.649e-148	472.0	COG2326@1|root,COG2326@2|Bacteria,46UWN@74201|Verrucomicrobia,2IVFJ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
TH2_k127_1314934_1	1396141.BATP01000001_gene5389	4.863e-230	725.0	COG0659@1|root,COG0659@2|Bacteria,46TUB@74201|Verrucomicrobia,2IVJF@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Sulfate permease family	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
TH2_k127_1314934_2	1396141.BATP01000002_gene4802	4.173e-183	579.0	COG0387@1|root,COG0387@2|Bacteria,46UPT@74201|Verrucomicrobia	74201|Verrucomicrobia	P	Sodium/calcium exchanger protein	-	-	-	-	-	-	-	-	-	-	-	-	Na_Ca_ex
TH2_k127_1314934_5	243233.MCA1632	2.37e-55	216.0	COG1196@1|root,COG3264@1|root,COG1196@2|Bacteria,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1XE6E@135618|Methylococcales	135618|Methylococcales	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
TH2_k127_1320328_14	404589.Anae109_4269	9.733e-05	46.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,42N3P@68525|delta/epsilon subdivisions,2WJB7@28221|Deltaproteobacteria,2YWT1@29|Myxococcales	28221|Deltaproteobacteria	H	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1259	ILVD_EDD
TH2_k127_1320328_1	1123517.JOMR01000001_gene360	7.556e-186	608.0	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,461T6@72273|Thiotrichales	72273|Thiotrichales	CP	COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter MnhA subunit	-	-	1.6.5.3	ko:K00341,ko:K05559	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,3.D.1	-	-	DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N
TH2_k127_1320328_5	1218076.BAYB01000029_gene4764	1.912e-30	126.0	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,1MW2M@1224|Proteobacteria,2VK56@28216|Betaproteobacteria,1K19T@119060|Burkholderiaceae	28216|Betaproteobacteria	CP	Subunit A of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali	phaA	-	-	ko:K05559	-	-	-	-	ko00000,ko02000	2.A.63.1	-	-	DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N
TH2_k127_1320328_8	1246484.D479_14767	1.748e-24	113.0	COG1006@1|root,COG1006@2|Bacteria,1V7CR@1239|Firmicutes,4HJHX@91061|Bacilli,3NEYC@45667|Halobacillus	91061|Bacilli	P	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	mrpC	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
TH2_k127_1320328_3	765914.ThisiDRAFT_0603	6.647e-135	446.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RQBG@1236|Gammaproteobacteria,1WVZA@135613|Chromatiales	135613|Chromatiales	CP	PFAM NADH Ubiquinone plastoquinone	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
TH2_k127_1320328_10	1267580.AF6_1922	1.356e-23	106.0	COG1863@1|root,COG1863@2|Bacteria,1V52M@1239|Firmicutes,4HI4G@91061|Bacilli	91061|Bacilli	P	subunit E of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali	mrpE	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
TH2_k127_1320328_11	1226994.AMZB01000133_gene4700	1.579e-23	103.0	COG1320@1|root,COG1320@2|Bacteria,1MZ6Z@1224|Proteobacteria,1S8TM@1236|Gammaproteobacteria,1YGU9@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	P	Na+/H+ antiporter subunit	phaG	-	-	ko:K05564,ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
TH2_k127_1320328_6	519989.ECTPHS_09098	1.039e-29	124.0	COG1863@1|root,COG1863@2|Bacteria,1N7MB@1224|Proteobacteria,1SCQX@1236|Gammaproteobacteria,1WYUR@135613|Chromatiales	135613|Chromatiales	P	PFAM cation antiporter	-	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
TH2_k127_1320328_13	1158146.KB907127_gene1703	4.917e-10	64.0	COG2212@1|root,COG2212@2|Bacteria,1N90U@1224|Proteobacteria	1224|Proteobacteria	P	Multiple resistance and pH regulation protein F	-	-	-	ko:K05570	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MrpF_PhaF
TH2_k127_1320328_9	425104.Ssed_1393	1.035e-23	109.0	COG1320@1|root,COG1320@2|Bacteria,1N75I@1224|Proteobacteria,1SCHB@1236|Gammaproteobacteria,2QE0F@267890|Shewanellaceae	1236|Gammaproteobacteria	P	Na+/H+ antiporter subunit	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
TH2_k127_1320328_4	1123368.AUIS01000004_gene134	2.673e-67	245.0	COG1563@1|root,COG1563@2|Bacteria,1RB3N@1224|Proteobacteria,1S74H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Domain related to MnhB subunit of Na+/H+ antiporter	-	-	-	-	-	-	-	-	-	-	-	-	DUF4040,MnhB
TH2_k127_1320328_12	425104.Ssed_1396	9.619e-21	105.0	COG1006@1|root,COG1006@2|Bacteria,1N7TX@1224|Proteobacteria,1SD0U@1236|Gammaproteobacteria,2QE07@267890|Shewanellaceae	1236|Gammaproteobacteria	P	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	-	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
TH2_k127_1320328_2	1123368.AUIS01000004_gene136	1.529e-162	525.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RYB4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CP	Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter MnhD subunit	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M,Proton_antipo_N
TH2_k127_1320328_0	1123368.AUIS01000004_gene137	2.751e-200	640.0	COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,1T20X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M,Proton_antipo_N
TH2_k127_1320328_7	1123242.JH636434_gene5314	4.731e-27	122.0	2CCV5@1|root,32RWG@2|Bacteria,2J30B@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_134032_6	556261.HMPREF0240_00122	5.384e-06	49.0	COG0407@1|root,COG0407@2|Bacteria,1UY51@1239|Firmicutes,24DZF@186801|Clostridia	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
TH2_k127_134032_5	537013.CLOSTMETH_00745	2.145e-11	78.0	COG3164@1|root,COG3250@1|root,COG3164@2|Bacteria,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	MA20_30770	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	AsmA_2,DUF3971,FIVAR,Glyco_hydro_106
TH2_k127_134032_3	1123024.AUII01000007_gene4841	3.128e-62	243.0	COG4733@1|root,COG4733@2|Bacteria,2I3TX@201174|Actinobacteria,4E0NG@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF2961)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2961
TH2_k127_134032_0	1499967.BAYZ01000059_gene4789	9.68e-96	334.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
TH2_k127_134032_2	1500304.JQKY01000017_gene2221	4.933e-80	274.0	COG1129@1|root,COG1129@2|Bacteria,1MW4I@1224|Proteobacteria,2TY4S@28211|Alphaproteobacteria,4BA4T@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	ABC-type sugar transport system, ATPase component	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
TH2_k127_134032_1	366394.Smed_5242	7.232e-91	308.0	COG1172@1|root,COG1172@2|Bacteria,1MUDF@1224|Proteobacteria,2TS7T@28211|Alphaproteobacteria,4BD4A@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
TH2_k127_134032_4	1500259.JQLD01000010_gene4777	2.103e-60	220.0	COG1879@1|root,COG1879@2|Bacteria,1N64A@1224|Proteobacteria,2UQM0@28211|Alphaproteobacteria,4BNFH@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Periplasmic binding protein domain	-	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Peripla_BP_4
TH2_k127_1396666_18	1123065.ATWL01000022_gene3710	1.229e-25	112.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria	201174|Actinobacteria	P	Pfam Sulfatase	-	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	Choline_sulf_C,Sulfatase
TH2_k127_1396666_19	627192.SLG_07280	2.72e-13	78.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1R7EM@1224|Proteobacteria,2TRZT@28211|Alphaproteobacteria,2K9UV@204457|Sphingomonadales	204457|Sphingomonadales	C	PQQ-like domain	-	-	1.1.9.1	ko:K17760	-	-	-	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3
TH2_k127_1396666_22	756272.Plabr_2416	0.0004406	49.0	COG1520@1|root,COG1520@2|Bacteria,2IWWY@203682|Planctomycetes	203682|Planctomycetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
TH2_k127_1396666_12	335543.Sfum_2073	5.697e-43	173.0	COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,42SN2@68525|delta/epsilon subdivisions,2WPT4@28221|Deltaproteobacteria,2MQM9@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	haloacid dehalogenase-like hydrolase	kdsC	-	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_3
TH2_k127_1396666_20	1232437.KL661964_gene3289	2.488e-11	73.0	COG1934@1|root,COG1934@2|Bacteria,1RM28@1224|Proteobacteria,42V9N@68525|delta/epsilon subdivisions,2WPUZ@28221|Deltaproteobacteria,2MKBD@213118|Desulfobacterales	28221|Deltaproteobacteria	S	OstA-like protein	-	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
TH2_k127_1396666_7	671143.DAMO_1189	1.733e-97	324.0	COG1137@1|root,COG1137@2|Bacteria,2NNRT@2323|unclassified Bacteria	2|Bacteria	S	lipopolysaccharide transport protein B ATP-binding component of ABC superfamily	lptB	GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K01990,ko:K06861	ko02010,map02010	M00254,M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1,3.A.1	-	-	ABC_tran,BCA_ABC_TP_C
TH2_k127_1396666_11	497964.CfE428DRAFT_4254	4.641e-49	181.0	COG1544@1|root,COG1544@2|Bacteria,46VGU@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Sigma 54 modulation/S30EA ribosomal protein C terminus	-	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
TH2_k127_1396666_5	497964.CfE428DRAFT_4273	8.715e-109	361.0	COG1493@1|root,COG1493@2|Bacteria,46S64@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
TH2_k127_1396666_17	794903.OPIT5_28795	2.715e-26	111.0	COG1925@1|root,COG1925@2|Bacteria,46T6C@74201|Verrucomicrobia,3K8AZ@414999|Opitutae	414999|Opitutae	G	PTS HPr component phosphorylation site	-	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
TH2_k127_1396666_1	273068.TTE2334	5.566e-164	534.0	COG1080@1|root,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,248QP@186801|Clostridia,42FHW@68295|Thermoanaerobacterales	186801|Clostridia	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsP	-	2.7.3.9,2.7.9.2	ko:K01007,ko:K08483	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00720,map01100,map01120,map01200,map02060	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
TH2_k127_1396666_10	478741.JAFS01000002_gene706	1.73e-74	258.0	COG1208@1|root,COG1208@2|Bacteria,46V3X@74201|Verrucomicrobia,37GGX@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	JM	Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TH2_k127_1396666_21	485913.Krac_11000	7.484e-05	49.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	5.3.1.12	ko:K01812,ko:K02529,ko:K16210	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	2.A.2.5	-	-	DDE_Tnp_ISAZ013,Peripla_BP_3
TH2_k127_1396666_16	485913.Krac_11000	1.269e-28	127.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	5.3.1.12	ko:K01812,ko:K02529,ko:K16210	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	2.A.2.5	-	-	DDE_Tnp_ISAZ013,Peripla_BP_3
TH2_k127_1396666_4	443143.GM18_3859	1.153e-112	372.0	COG0061@1|root,COG0061@2|Bacteria,1NBI3@1224|Proteobacteria,42ZTT@68525|delta/epsilon subdivisions,2WV8A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1396666_2	1173264.KI913949_gene1409	5.583e-127	414.0	COG0330@1|root,COG0330@2|Bacteria	2|Bacteria	O	stress-induced mitochondrial fusion	cnpD	-	-	-	-	-	-	-	-	-	-	-	Band_7
TH2_k127_1396666_8	1396141.BATP01000030_gene3653	2.918e-86	289.0	COG1335@1|root,COG1335@2|Bacteria,46UUK@74201|Verrucomicrobia	74201|Verrucomicrobia	Q	isochorismatase hydrolase	-	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
TH2_k127_1396666_6	118173.KB235914_gene3009	3.461e-103	352.0	COG1051@1|root,COG1051@2|Bacteria,1G3M0@1117|Cyanobacteria,1HA4P@1150|Oscillatoriales	1117|Cyanobacteria	F	Belongs to the Nudix hydrolase family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
TH2_k127_1396666_0	313606.M23134_05245	1.277e-207	655.0	COG1488@1|root,COG1488@2|Bacteria,4NFQK@976|Bacteroidetes,47MZ6@768503|Cytophagia	976|Bacteroidetes	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
TH2_k127_1396666_13	926550.CLDAP_05300	1.307e-42	169.0	COG1225@1|root,COG1225@2|Bacteria,2G6TX@200795|Chloroflexi	200795|Chloroflexi	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
TH2_k127_1396666_9	926550.CLDAP_25410	4.715e-75	259.0	COG0177@1|root,COG0177@2|Bacteria,2G6A1@200795|Chloroflexi	200795|Chloroflexi	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
TH2_k127_1396666_14	756272.Plabr_3562	1.616e-34	134.0	COG1146@1|root,COG1146@2|Bacteria,2J013@203682|Planctomycetes	203682|Planctomycetes	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	-	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	DUF3470,Fer4
TH2_k127_1396666_3	358681.BBR47_36230	2.292e-113	380.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,4H9SD@91061|Bacilli,26QJA@186822|Paenibacillaceae	91061|Bacilli	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF3	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TH2_k127_1396666_15	497964.CfE428DRAFT_5468	2.359e-32	141.0	COG5000@1|root,COG5000@2|Bacteria,46THS@74201|Verrucomicrobia	74201|Verrucomicrobia	T	ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
TH2_k127_1442112_4	335543.Sfum_1460	5.446e-139	453.0	COG0025@1|root,COG0025@2|Bacteria,1QTUE@1224|Proteobacteria,43CF5@68525|delta/epsilon subdivisions,2WMDP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
TH2_k127_1442112_8	1349767.GJA_4518	6.984e-87	300.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2VIIX@28216|Betaproteobacteria,475P1@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TH2_k127_1442112_6	204669.Acid345_4072	3.863e-110	383.0	COG1538@1|root,COG1538@2|Bacteria,3Y2NR@57723|Acidobacteria,2JHZY@204432|Acidobacteriia	204432|Acidobacteriia	MU	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
TH2_k127_1442112_0	335543.Sfum_1457	0.0	1037.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,2MR4N@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	Protein export membrane protein	bepE	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
TH2_k127_1442112_9	1304885.AUEY01000002_gene359	1.921e-80	282.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42Q4P@68525|delta/epsilon subdivisions,2WJHQ@28221|Deltaproteobacteria,2MJRC@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Biotin-lipoyl like	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
TH2_k127_1442112_10	933262.AXAM01000081_gene2262	2.23e-78	280.0	COG0543@1|root,COG0543@2|Bacteria,1RF43@1224|Proteobacteria,42RQK@68525|delta/epsilon subdivisions,2WNJU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
TH2_k127_1442112_7	933262.AXAM01000064_gene589	4.504e-98	342.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,42M46@68525|delta/epsilon subdivisions,2WJ7G@28221|Deltaproteobacteria,2MIHH@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.14,1.3.5.2	ko:K00254,ko:K02823,ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01868,R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
TH2_k127_1442112_11	502025.Hoch_3429	8.565e-72	250.0	COG0225@1|root,COG0225@2|Bacteria,1R33Z@1224|Proteobacteria,42YM8@68525|delta/epsilon subdivisions,2WTXS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	-	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
TH2_k127_1442112_2	1121017.AUFG01000010_gene1661	6.541e-175	558.0	COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4FEQ1@85021|Intrasporangiaceae	201174|Actinobacteria	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
TH2_k127_1442112_3	1125863.JAFN01000001_gene1773	7.98e-156	502.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,42M5K@68525|delta/epsilon subdivisions,2WJTS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2261	ATP-grasp_2,Ligase_CoA
TH2_k127_1442112_5	1089548.KI783301_gene639	2.376e-127	413.0	COG0074@1|root,COG0074@2|Bacteria,1TPIT@1239|Firmicutes,4HA2J@91061|Bacilli,3WFA3@539002|Bacillales incertae sedis	91061|Bacilli	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
TH2_k127_1442112_12	411464.DESPIG_02427	1.27e-44	179.0	COG0349@1|root,COG0349@2|Bacteria,1REMB@1224|Proteobacteria,42S18@68525|delta/epsilon subdivisions,2WN9J@28221|Deltaproteobacteria,2MAMV@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	3'-5' exonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DNA_pol_A_exo1
TH2_k127_1442112_13	1396141.BATP01000021_gene146	9.099e-39	150.0	COG1694@1|root,COG1694@2|Bacteria,46W6C@74201|Verrucomicrobia,2IW7F@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	MazG-like family	-	-	-	-	-	-	-	-	-	-	-	-	MazG-like
TH2_k127_1442112_1	278957.ABEA03000215_gene4259	2.374e-205	644.0	COG0137@1|root,COG0137@2|Bacteria,46SCU@74201|Verrucomicrobia,3K7AT@414999|Opitutae	414999|Opitutae	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
TH2_k127_1445083_0	234267.Acid_4184	0.0	1125.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,3Y37Y@57723|Acidobacteria	57723|Acidobacteria	E	Vitamin B12 dependent methionine synthase activation	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
TH2_k127_1445083_1	1121104.AQXH01000001_gene1034	2.195e-49	185.0	COG0204@1|root,COG0204@2|Bacteria	2|Bacteria	I	Acyl-transferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TH2_k127_1445083_2	243090.RB3866	1.628e-09	68.0	2EQUR@1|root,33IEH@2|Bacteria,2J1JE@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1555817_5	857087.Metme_2935	1.794e-27	125.0	COG2067@1|root,COG2067@2|Bacteria,1NQ4A@1224|Proteobacteria,1RYKE@1236|Gammaproteobacteria,1XEJE@135618|Methylococcales	135618|Methylococcales	I	Putative beta-barrel porin-2, OmpL-like. bbp2	-	-	-	-	-	-	-	-	-	-	-	-	BBP2
TH2_k127_1555817_2	1123388.AQWU01000059_gene829	8.118e-111	371.0	COG3842@1|root,COG3842@2|Bacteria,1WIWM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	-	3.6.3.31	ko:K11072	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1	-	-	ABC_tran,TOBE_2
TH2_k127_1555817_4	321327.CYA_1858	1.521e-71	256.0	COG1176@1|root,COG1176@2|Bacteria,1G127@1117|Cyanobacteria,1H1QV@1129|Synechococcus	1117|Cyanobacteria	P	ABC transporter, permease protein	potB	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
TH2_k127_1555817_3	321332.CYB_2209	6.59e-78	271.0	COG1177@1|root,COG1177@2|Bacteria,1G1B6@1117|Cyanobacteria,1H1XK@1129|Synechococcus	1117|Cyanobacteria	P	ABC transporter, permease protein	potC	-	-	ko:K02053,ko:K11070	ko02010,ko02024,map02010,map02024	M00193,M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11,3.A.1.11.1	-	-	BPD_transp_1
TH2_k127_1555817_1	1122223.KB890700_gene1996	5.698e-115	383.0	COG0687@1|root,COG0687@2|Bacteria,1WIRI@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Spermidine putrescine-binding periplasmic protein	-	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_8
TH2_k127_1555817_0	1121472.AQWN01000010_gene611	1.248e-176	566.0	COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,248C9@186801|Clostridia,2608J@186807|Peptococcaceae	186801|Clostridia	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.11,2.6.1.17,2.6.1.82	ko:K00821,ko:K09251	ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R01155,R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TH2_k127_1582608_0	661478.OP10G_2108	1.858e-138	465.0	28J96@1|root,2Z947@2|Bacteria	2|Bacteria	S	PFAM Oligopeptide transporter OPT superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1582608_2	1121451.DESAM_22436	1.271e-25	114.0	COG0577@1|root,COG0577@2|Bacteria,1RC4T@1224|Proteobacteria,42QZ6@68525|delta/epsilon subdivisions,2WMU4@28221|Deltaproteobacteria,2MB5S@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
TH2_k127_1582608_1	1121403.AUCV01000020_gene3139	1.319e-94	325.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,4308T@68525|delta/epsilon subdivisions,2WKJ3@28221|Deltaproteobacteria,2MIDE@213118|Desulfobacterales	28221|Deltaproteobacteria	V	PFAM ABC transporter related	lolD-2	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TH2_k127_1639264_1	1232410.KI421421_gene3769	1.618e-81	280.0	COG0845@1|root,COG0845@2|Bacteria,1PEVY@1224|Proteobacteria,42NTH@68525|delta/epsilon subdivisions,2WJ8N@28221|Deltaproteobacteria,43S96@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3
TH2_k127_1639264_0	1232410.KI421421_gene3768	0.0	1310.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria,43S1Y@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
TH2_k127_1670788_2	760142.Hipma_0476	2.082e-167	548.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2M6BJ@213113|Desulfurellales	28221|Deltaproteobacteria	NU	Type II secretion system protein E	pilB	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N,cNMP_binding
TH2_k127_1670788_1	518766.Rmar_2008	2.433e-184	591.0	COG1012@1|root,COG1012@2|Bacteria,4NEB7@976|Bacteroidetes,1FJ1P@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.79	ko:K00128,ko:K00135	ko00010,ko00053,ko00071,ko00250,ko00280,ko00310,ko00330,ko00340,ko00350,ko00380,ko00410,ko00561,ko00620,ko00625,ko00650,ko00760,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00250,map00280,map00310,map00330,map00340,map00350,map00380,map00410,map00561,map00620,map00625,map00650,map00760,map00903,map00981,map01100,map01110,map01120,map01130	M00027,M00135	R00264,R00631,R00710,R00713,R00714,R00904,R01752,R01986,R02401,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TH2_k127_1670788_6	497964.CfE428DRAFT_4839	3.544e-112	369.0	COG0568@1|root,COG0568@2|Bacteria,46SJ8@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TH2_k127_1670788_17	384765.SIAM614_14770	1.023e-25	111.0	COG3427@1|root,COG3427@2|Bacteria,1RHUC@1224|Proteobacteria,2U9HD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	carbon monoxide dehydrogenase	coxG	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
TH2_k127_1670788_5	794903.OPIT5_18300	1.879e-113	396.0	COG1132@1|root,COG1132@2|Bacteria,46S6K@74201|Verrucomicrobia,3K7CG@414999|Opitutae	414999|Opitutae	V	ABC transporter	-	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
TH2_k127_1670788_12	1187851.A33M_3007	1.931e-60	213.0	COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,2U7C4@28211|Alphaproteobacteria,3FD38@34008|Rhodovulum	28211|Alphaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
TH2_k127_1670788_14	314230.DSM3645_11582	1.331e-30	125.0	COG0211@1|root,COG0211@2|Bacteria,2J04T@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
TH2_k127_1670788_15	1123371.ATXH01000027_gene160	5.052e-28	117.0	COG0261@1|root,COG0261@2|Bacteria,2GHY6@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
TH2_k127_1670788_10	497964.CfE428DRAFT_0873	4.012e-67	241.0	COG0289@1|root,COG0289@2|Bacteria,46SPR@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
TH2_k127_1670788_7	478741.JAFS01000002_gene313	1.641e-99	338.0	COG0329@1|root,COG0329@2|Bacteria,46SDY@74201|Verrucomicrobia,37G2R@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	EM	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
TH2_k127_1670788_16	69042.WH5701_04145	6.465e-27	115.0	COG1569@1|root,COG1569@2|Bacteria,1G7ZZ@1117|Cyanobacteria,1H17D@1129|Synechococcus	1117|Cyanobacteria	S	PIN domain	-	-	-	ko:K07063	-	-	-	-	ko00000	-	-	-	PIN_3
TH2_k127_1670788_0	204669.Acid345_4052	0.0	1341.0	COG0204@1|root,COG0318@1|root,COG0477@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,COG2814@2|Bacteria,3Y4RT@57723|Acidobacteria	57723|Acidobacteria	IQ	Phosphate acyltransferases	-	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding,Acyltransferase,MFS_1
TH2_k127_1670788_4	497964.CfE428DRAFT_3408	3.156e-115	402.0	28M0D@1|root,2ZAFE@2|Bacteria,46TXJ@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Putative ATP-binding cassette	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran_2
TH2_k127_1670788_9	497964.CfE428DRAFT_5932	4.69e-81	287.0	COG1131@1|root,COG1131@2|Bacteria,46TZ8@74201|Verrucomicrobia	74201|Verrucomicrobia	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TH2_k127_1670788_18	452637.Oter_0628	1.067e-17	95.0	COG0457@1|root,COG1652@1|root,COG0457@2|Bacteria,COG1652@2|Bacteria,46T8E@74201|Verrucomicrobia,3K82V@414999|Opitutae	414999|Opitutae	S	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
TH2_k127_1670788_11	1396418.BATQ01000001_gene1308	1.004e-63	229.0	COG1385@1|root,COG1385@2|Bacteria,46SZQ@74201|Verrucomicrobia,2IUB0@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
TH2_k127_1670788_3	497964.CfE428DRAFT_2333	7.756e-159	517.0	COG0436@1|root,COG0436@2|Bacteria,46SFZ@74201|Verrucomicrobia	74201|Verrucomicrobia	E	aminotransferase class I and II	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
TH2_k127_1670788_8	497964.CfE428DRAFT_1082	2.608e-98	328.0	COG1222@1|root,COG1222@2|Bacteria,46UBC@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Proteasomal ATPase OB/ID domain	-	-	-	ko:K13527	ko03050,map03050	M00342	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA,Prot_ATP_ID_OB
TH2_k127_1689519_16	314230.DSM3645_21949	3.157e-17	85.0	2DSIM@1|root,33GAK@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF4236)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4236
TH2_k127_1689519_21	1070774.J07HN4v3_00013	0.000512	51.0	COG1913@1|root,arCOG00458@2157|Archaea,2XSVV@28890|Euryarchaeota,23T85@183963|Halobacteria	183963|Halobacteria	S	zinc metalloprotease whose natural substrate is	amzA	-	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
TH2_k127_1689519_13	530564.Psta_3364	1.886e-35	138.0	2E0F1@1|root,32W1E@2|Bacteria,2J31G@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1689519_0	859657.RPSI07_2566	0.0	1242.0	COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,2VH5H@28216|Betaproteobacteria,1K3VG@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
TH2_k127_1689519_14	382464.ABSI01000002_gene4350	1.325e-26	114.0	COG2001@1|root,COG2001@2|Bacteria,46T5G@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
TH2_k127_1689519_8	521098.Aaci_1269	3.387e-95	322.0	COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,4H9U2@91061|Bacilli,2797Y@186823|Alicyclobacillaceae	91061|Bacilli	M	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
TH2_k127_1689519_3	398767.Glov_0676	2.411e-124	423.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,42M1T@68525|delta/epsilon subdivisions,2WK0W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Penicillin-binding protein, dimerisation domain	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
TH2_k127_1689519_2	264732.Moth_0838	6.876e-141	465.0	COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,248Q4@186801|Clostridia,42ETI@68295|Thermoanaerobacterales	186801|Clostridia	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TH2_k127_1689519_6	497964.CfE428DRAFT_2938	1.782e-105	364.0	COG0770@1|root,COG0770@2|Bacteria,46SDF@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TH2_k127_1689519_4	497964.CfE428DRAFT_2937	8.596e-122	401.0	COG0472@1|root,COG0472@2|Bacteria,46SD0@74201|Verrucomicrobia	74201|Verrucomicrobia	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
TH2_k127_1689519_7	497964.CfE428DRAFT_2936	5.222e-100	350.0	COG0771@1|root,COG0771@2|Bacteria,46UUH@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
TH2_k127_1689519_15	1123284.KB899046_gene2240	2.006e-17	94.0	COG0791@1|root,COG1388@1|root,COG0791@2|Bacteria,COG1388@2|Bacteria,1V9ZW@1239|Firmicutes,4HH84@91061|Bacilli,26PXP@186821|Sporolactobacillaceae	91061|Bacilli	M	NlpC/P60 family	ydhO1	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,LysM,NLPC_P60,SH3_3
TH2_k127_1689519_9	240016.ABIZ01000001_gene3508	4.676e-90	309.0	COG0772@1|root,COG0772@2|Bacteria,46SMC@74201|Verrucomicrobia,2ITN2@203494|Verrucomicrobiae	203494|Verrucomicrobiae	D	Cell cycle protein	-	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
TH2_k127_1689519_10	497964.CfE428DRAFT_2933	1.236e-83	290.0	COG0707@1|root,COG0707@2|Bacteria,46S84@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
TH2_k127_1689519_1	1396141.BATP01000041_gene2222	8.099e-175	578.0	COG0773@1|root,COG0812@1|root,COG0773@2|Bacteria,COG0812@2|Bacteria,46SCG@74201|Verrucomicrobia,2ITNT@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain	murB	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4,MurB_C,Mur_ligase,Mur_ligase_C,Mur_ligase_M
TH2_k127_1689519_12	478741.JAFS01000001_gene1134	2.297e-77	270.0	COG1181@1|root,COG1181@2|Bacteria,46UZ2@74201|Verrucomicrobia,37GF6@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	F	D-ala D-ala ligase N-terminus	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
TH2_k127_1689519_17	349161.Dred_0679	1.541e-13	81.0	COG1589@1|root,COG1589@2|Bacteria,1VEMW@1239|Firmicutes,24QKM@186801|Clostridia,26202@186807|Peptococcaceae	186801|Clostridia	D	Cell division protein FtsQ	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
TH2_k127_1689519_5	497964.CfE428DRAFT_2928	9.971e-115	383.0	COG0849@1|root,COG0849@2|Bacteria,46SQI@74201|Verrucomicrobia	74201|Verrucomicrobia	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
TH2_k127_1689519_11	794903.OPIT5_03600	3.318e-78	280.0	COG0206@1|root,COG0206@2|Bacteria,46UAJ@74201|Verrucomicrobia,3K7KG@414999|Opitutae	414999|Opitutae	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
TH2_k127_1689519_19	1108045.GORHZ_247_00260	2.647e-11	76.0	COG3209@1|root,COG5412@1|root,COG3209@2|Bacteria,COG5412@2|Bacteria,2GK1D@201174|Actinobacteria	201174|Actinobacteria	M	TIGRFAM YD repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	SpvB,TcdB_toxin_midC,TcdB_toxin_midN,VCBS
TH2_k127_1689519_20	234267.Acid_3349	2.064e-07	62.0	COG3518@1|root,COG3518@2|Bacteria	2|Bacteria	S	anti-sigma factor antagonist activity	iraD	GO:0000988,GO:0000989,GO:0003674,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010605,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033554,GO:0042176,GO:0042177,GO:0043856,GO:0045893,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051248,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K11897,ko:K21637	-	M00334	-	-	ko00000,ko00002,ko02044	-	-	-	GPW_gp25
TH2_k127_1711730_0	477184.KYC_28187	2.563e-178	582.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2W0PN@28216|Betaproteobacteria,3T3EY@506|Alcaligenaceae	28216|Betaproteobacteria	C	COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
TH2_k127_1711730_2	935565.JAEM01000016_gene1461	1.301e-14	81.0	COG0346@1|root,COG0346@2|Bacteria,1N4MJ@1224|Proteobacteria,2UDJP@28211|Alphaproteobacteria,2PYVX@265|Paracoccus	28211|Alphaproteobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TH2_k127_179759_6	118163.Ple7327_1940	1.114e-21	102.0	28N1B@1|root,2ZB7I@2|Bacteria,1G011@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_179759_5	278957.ABEA03000200_gene4367	4.309e-27	119.0	2C6QH@1|root,33V43@2|Bacteria,46V9K@74201|Verrucomicrobia,3K7BV@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_179759_1	497964.CfE428DRAFT_6073	1.807e-81	289.0	COG0860@1|root,COG0860@2|Bacteria,46SKJ@74201|Verrucomicrobia	74201|Verrucomicrobia	M	N-acetylmuramoyl-L-alanine amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_3
TH2_k127_179759_2	1089553.Tph_c13510	5.93e-62	218.0	COG0432@1|root,COG0432@2|Bacteria,1V201@1239|Firmicutes,24FTY@186801|Clostridia,42G53@68295|Thermoanaerobacterales	186801|Clostridia	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
TH2_k127_179759_4	314230.DSM3645_11122	2.556e-31	126.0	COG1917@1|root,COG1917@2|Bacteria,2J1N5@203682|Planctomycetes	203682|Planctomycetes	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_179759_3	926550.CLDAP_33530	2.008e-50	188.0	COG2096@1|root,COG2096@2|Bacteria,2G6TB@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Cobalamin adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
TH2_k127_179759_0	497964.CfE428DRAFT_1577	5.023e-138	449.0	COG0502@1|root,COG0502@2|Bacteria,46SFX@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Biotin and Thiamin Synthesis associated domain	-	-	4.1.99.19	ko:K03150	ko00730,ko01100,map00730,map01100	-	R10246	RC01434,RC03095	ko00000,ko00001,ko01000	-	-	-	BATS,Radical_SAM
TH2_k127_179759_8	1304275.C41B8_11518	6.113e-05	49.0	COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,1RMPD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	iECABU_c1320.ECABU_c45060,iECO26_1355.ECO26_5099,ic_1306.c4947	ThiG
TH2_k127_179759_7	1226325.HMPREF1548_03574	8.46e-08	56.0	COG3669@1|root,COG3669@2|Bacteria,1TQH2@1239|Firmicutes,24B8Y@186801|Clostridia,36F4D@31979|Clostridiaceae	186801|Clostridia	G	Psort location Cytoplasmic, score 7.50	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
TH2_k127_182519_13	645465.ACUR01000653_gene3792	2.867e-10	70.0	2DGAD@1|root,2ZV4Y@2|Bacteria,2IF7H@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_182519_12	479435.Kfla_5892	1.132e-12	72.0	COG2207@1|root,COG2207@2|Bacteria,2IHDB@201174|Actinobacteria	201174|Actinobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TH2_k127_182519_9	246196.MSMEI_6504	1.069e-54	205.0	COG1874@1|root,COG1874@2|Bacteria,2IAE5@201174|Actinobacteria	201174|Actinobacteria	G	Beta-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_182519_8	1463820.JOGW01000005_gene3331	1.679e-58	226.0	2DGAD@1|root,2ZV4Y@2|Bacteria,2IF7H@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_182519_3	1396141.BATP01000004_gene5932	1.15e-117	401.0	COG2812@1|root,COG2812@2|Bacteria,46SGC@74201|Verrucomicrobia,2ITGI@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
TH2_k127_182519_10	1121472.AQWN01000007_gene1087	1.632e-23	105.0	COG0718@1|root,COG0718@2|Bacteria,1VA1S@1239|Firmicutes,24MXH@186801|Clostridia,262CP@186807|Peptococcaceae	186801|Clostridia	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
TH2_k127_182519_7	767817.Desgi_0066	8.967e-60	213.0	COG0353@1|root,COG0353@2|Bacteria,1TR87@1239|Firmicutes,2487H@186801|Clostridia,2612W@186807|Peptococcaceae	186801|Clostridia	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
TH2_k127_182519_5	478741.JAFS01000001_gene1051	3.824e-93	312.0	COG0842@1|root,COG0842@2|Bacteria,46UQ0@74201|Verrucomicrobia,37GJ6@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TH2_k127_182519_4	497964.CfE428DRAFT_3635	2.81e-98	347.0	COG0782@1|root,COG1747@1|root,COG0782@2|Bacteria,COG1747@2|Bacteria,46S7F@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	-	-	-	-	-	-	-	-	-	GreA_GreB,GreA_GreB_N
TH2_k127_182519_16	1121124.JNIX01000013_gene1478	0.0002412	49.0	COG4575@1|root,COG4575@2|Bacteria,1NHND@1224|Proteobacteria,2UK1G@28211|Alphaproteobacteria,2KHH4@204458|Caulobacterales	204458|Caulobacterales	S	ribosome binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF883
TH2_k127_182519_15	1415779.JOMH01000001_gene1591	0.0001088	51.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria,1X4C9@135614|Xanthomonadales	135614|Xanthomonadales	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TH2_k127_182519_11	1396141.BATP01000022_gene383	7.556e-19	102.0	COG1595@1|root,COG1595@2|Bacteria,46TQ4@74201|Verrucomicrobia,2IVYP@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4
TH2_k127_182519_14	1396141.BATP01000059_gene2547	3.432e-06	60.0	2AYZ8@1|root,31R54@2|Bacteria,46WP8@74201|Verrucomicrobia	1396141.BATP01000059_gene2547|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_182519_0	485913.Krac_5916	5.39e-321	998.0	COG0578@1|root,COG0578@2|Bacteria	2|Bacteria	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	-	-	1.1.5.3,3.1.21.3	ko:K00111,ko:K01153	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000,ko02048	-	-	-	DAO,DAO_C,DUF4145,EcoEI_R_C,FAD_oxidored,HSDR_N,Helicase_C,ResIII
TH2_k127_182519_2	309801.trd_1634	1.775e-123	407.0	COG1104@1|root,COG1104@2|Bacteria,2G63V@200795|Chloroflexi,27XYX@189775|Thermomicrobia	189775|Thermomicrobia	E	Beta-eliminating lyase	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
TH2_k127_182519_6	1396418.BATQ01000020_gene5054	1.97e-91	312.0	COG1045@1|root,COG1045@2|Bacteria,46S5J@74201|Verrucomicrobia,2ITZ0@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,SATase_N
TH2_k127_182519_1	886293.Sinac_6948	4.49e-145	472.0	COG0665@1|root,COG0665@2|Bacteria,2J4YV@203682|Planctomycetes	203682|Planctomycetes	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
TH2_k127_185360_0	868595.Desca_2185	1.045e-106	361.0	COG0337@1|root,COG0337@2|Bacteria,1TPKZ@1239|Firmicutes,248H4@186801|Clostridia,25ZZM@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
TH2_k127_185360_1	338966.Ppro_2108	1.338e-47	173.0	COG0614@1|root,COG0614@2|Bacteria,1N7EM@1224|Proteobacteria,42VJU@68525|delta/epsilon subdivisions,2XA0J@28221|Deltaproteobacteria,43VJ7@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
TH2_k127_185360_2	497964.CfE428DRAFT_5447	7.276e-11	64.0	COG0758@1|root,COG0758@2|Bacteria,46SGR@74201|Verrucomicrobia	74201|Verrucomicrobia	L	TIGRFAM DNA protecting protein DprA	smf	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A,HHH_5
TH2_k127_1856448_1	472759.Nhal_3806	2.571e-37	147.0	COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,1S0GF@1236|Gammaproteobacteria,1X0AW@135613|Chromatiales	135613|Chromatiales	S	Serine aminopeptidase, S33	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
TH2_k127_1856448_0	479433.Caci_3422	4.948e-56	215.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	B12-binding,Radical_SAM
TH2_k127_189530_3	32057.KB217478_gene5607	3.555e-08	61.0	COG0553@1|root,COG3886@1|root,COG0553@2|Bacteria,COG3886@2|Bacteria,1FZVD@1117|Cyanobacteria,1HP5E@1161|Nostocales	1117|Cyanobacteria	L	PLD-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,PLDc_2,SNF2_N
TH2_k127_189530_1	1034943.BN1094_02561	8.24e-54	202.0	COG1183@1|root,COG1183@2|Bacteria,1NGCJ@1224|Proteobacteria,1S88D@1236|Gammaproteobacteria,1JDWD@118969|Legionellales	118969|Legionellales	I	Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP	lidK	GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050520,GO:0071704,GO:0090407,GO:1901576	2.7.8.24	ko:K01004	ko00564,ko01110,map00564,map01110	-	R05794	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TH2_k127_189530_2	497964.CfE428DRAFT_0420	3.414e-41	163.0	2AY99@1|root,31QBJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_189530_0	481448.Minf_0082	8.545e-128	419.0	COG0469@1|root,COG0469@2|Bacteria,46SBJ@74201|Verrucomicrobia,37FYI@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	G	Pyruvate kinase, alpha/beta domain	pykF	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
TH2_k127_1924146_3	1267535.KB906767_gene604	2.075e-147	476.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,3Y37Y@57723|Acidobacteria,2JI9E@204432|Acidobacteriia	204432|Acidobacteriia	E	Vitamin B12 dependent methionine synthase activation	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
TH2_k127_1924146_5	1123252.ATZF01000009_gene661	4.99e-111	370.0	COG1522@1|root,COG1522@2|Bacteria,1V6TH@1239|Firmicutes,4HAAQ@91061|Bacilli,27CKF@186824|Thermoactinomycetaceae	91061|Bacilli	K	AsnC-type helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
TH2_k127_1924146_1	1122221.JHVI01000009_gene2658	9.875e-176	566.0	COG1249@1|root,COG1249@2|Bacteria,1WI3A@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3)	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
TH2_k127_1924146_4	502025.Hoch_4995	1.092e-145	475.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,42N18@68525|delta/epsilon subdivisions,2WJSK@28221|Deltaproteobacteria,2Z2W5@29|Myxococcales	28221|Deltaproteobacteria	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	sucB	-	2.3.1.12,2.3.1.61	ko:K00627,ko:K00658	ko00010,ko00020,ko00310,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00310,map00620,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032,M00307	R00209,R02569,R02570,R02571,R08549	RC00004,RC02727,RC02742,RC02833,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2766	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TH2_k127_1924146_0	290397.Adeh_0781	4.869e-287	910.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,42NY6@68525|delta/epsilon subdivisions,2WJSE@28221|Deltaproteobacteria,2YU0W@29|Myxococcales	28221|Deltaproteobacteria	C	dehydrogenase, E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
TH2_k127_1924146_6	497964.CfE428DRAFT_2959	4.572e-51	191.0	2ED0A@1|root,336X9@2|Bacteria,46TCE@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1924146_7	452637.Oter_0893	1.971e-34	135.0	COG0695@1|root,COG0695@2|Bacteria,46SXS@74201|Verrucomicrobia,3K871@414999|Opitutae	414999|Opitutae	O	Glutaredoxin	-	-	-	ko:K07390	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Glutaredoxin
TH2_k127_1924146_2	649638.Trad_2886	1.496e-160	522.0	COG1057@1|root,COG1057@2|Bacteria	2|Bacteria	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.7.18,3.6.1.55	ko:K00969,ko:K03574	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	CTP_transf_like
TH2_k127_1978095_13	43989.cce_3968	3.231e-16	94.0	28N1B@1|root,2ZB7I@2|Bacteria,1G011@1117|Cyanobacteria,3KH8M@43988|Cyanothece	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1978095_15	118168.MC7420_1277	5.27e-06	59.0	28N1B@1|root,2ZB7I@2|Bacteria,1G011@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_1978095_8	497964.CfE428DRAFT_4923	5.513e-57	203.0	COG0583@1|root,COG0583@2|Bacteria,46SDJ@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Transcriptional regulator	-	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
TH2_k127_1978095_11	1191523.MROS_1077	3.245e-27	114.0	COG0599@1|root,COG0599@2|Bacteria	2|Bacteria	S	peroxiredoxin activity	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
TH2_k127_1978095_1	497964.CfE428DRAFT_5160	9.493e-191	614.0	COG2304@1|root,COG2304@2|Bacteria,46WAG@74201|Verrucomicrobia	2|Bacteria	S	Aerotolerance regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
TH2_k127_1978095_3	1123242.JH636434_gene5311	2.862e-107	355.0	COG1721@1|root,COG1721@2|Bacteria,2IY59@203682|Planctomycetes	203682|Planctomycetes	S	protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
TH2_k127_1978095_2	497964.CfE428DRAFT_5158	4.415e-144	464.0	COG0714@1|root,COG0714@2|Bacteria,46UWS@74201|Verrucomicrobia	2|Bacteria	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TH2_k127_1978095_9	1499967.BAYZ01000171_gene5621	3.36e-52	188.0	COG1943@1|root,COG1943@2|Bacteria,2NR5I@2323|unclassified Bacteria	2|Bacteria	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
TH2_k127_1978095_0	344747.PM8797T_28944	0.0	1098.0	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,2IXKI@203682|Planctomycetes	203682|Planctomycetes	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	GATase1_like,VWA,VWA_3
TH2_k127_1978095_4	497964.CfE428DRAFT_5153	3.001e-103	349.0	COG3391@1|root,COG3842@1|root,COG3391@2|Bacteria,COG3842@2|Bacteria	2|Bacteria	P	ATPase activity	gtsA	-	3.6.3.30,3.6.3.55	ko:K02010,ko:K02049,ko:K02068,ko:K02071,ko:K06857,ko:K10112	ko02010,map02010	M00186,M00188,M00190,M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00211,M00238,M00491,M00602,M00605,M00606	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1,3.A.1.10,3.A.1.16,3.A.1.17,3.A.1.24,3.A.1.6.2,3.A.1.6.4	-	-	ABC_tran,SGL,TOBE_2
TH2_k127_1978095_5	497964.CfE428DRAFT_5153	2.195e-83	288.0	COG3391@1|root,COG3842@1|root,COG3391@2|Bacteria,COG3842@2|Bacteria	2|Bacteria	P	ATPase activity	gtsA	-	3.6.3.30,3.6.3.55	ko:K02010,ko:K02049,ko:K02068,ko:K02071,ko:K06857,ko:K10112	ko02010,map02010	M00186,M00188,M00190,M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00211,M00238,M00491,M00602,M00605,M00606	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1,3.A.1.10,3.A.1.16,3.A.1.17,3.A.1.24,3.A.1.6.2,3.A.1.6.4	-	-	ABC_tran,SGL,TOBE_2
TH2_k127_1978095_12	1170562.Cal6303_4474	1.179e-19	94.0	COG3668@1|root,COG3668@2|Bacteria,1GKIY@1117|Cyanobacteria,1HT0C@1161|Nostocales	1117|Cyanobacteria	S	PFAM Plasmid stabilisation system protein	-	-	-	ko:K19092	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
TH2_k127_1978095_7	1396418.BATQ01000028_gene5247	2.296e-62	231.0	COG1466@1|root,COG1466@2|Bacteria,46T5Y@74201|Verrucomicrobia,2ITP3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	DNA polymerase III, delta subunit	-	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
TH2_k127_1978095_10	1396141.BATP01000042_gene1912	3.863e-45	171.0	COG2129@1|root,COG2129@2|Bacteria	2|Bacteria	L	metallophosphoesterase	Z012_09970	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
TH2_k127_1978095_6	1396141.BATP01000032_gene4324	2.393e-82	284.0	COG0265@1|root,COG0265@2|Bacteria,46SHP@74201|Verrucomicrobia,2IU51@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
TH2_k127_2104932_4	595460.RRSWK_06201	9.847e-26	119.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Sulfotransfer_3
TH2_k127_2104932_0	452637.Oter_0816	2.713e-215	675.0	COG1350@1|root,COG1350@2|Bacteria	2|Bacteria	E	tryptophan synthase activity	trpB	-	4.2.1.20	ko:K01696,ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TH2_k127_2104932_1	794903.OPIT5_28575	1.351e-179	565.0	COG0191@1|root,COG0191@2|Bacteria,46TAJ@74201|Verrucomicrobia,3K7BF@414999|Opitutae	414999|Opitutae	G	Fructose-bisphosphate aldolase class-II	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
TH2_k127_2104932_3	497964.CfE428DRAFT_2957	2.673e-32	130.0	COG2026@1|root,COG2026@2|Bacteria,46T5H@74201|Verrucomicrobia	74201|Verrucomicrobia	DJ	Addiction module toxin, RelE StbE family	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
TH2_k127_2104932_2	1121904.ARBP01000040_gene530	4.881e-58	216.0	COG3119@1|root,COG3119@2|Bacteria,4NGX1@976|Bacteroidetes,47K2H@768503|Cytophagia	976|Bacteroidetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TH2_k127_2105441_6	452637.Oter_2739	9.423e-69	248.0	COG0544@1|root,COG0544@2|Bacteria,46SJZ@74201|Verrucomicrobia,3K7I6@414999|Opitutae	414999|Opitutae	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	Trigger_C,Trigger_N
TH2_k127_2105441_3	1156937.MFUM_170024	1.885e-95	316.0	COG0740@1|root,COG0740@2|Bacteria,46SAB@74201|Verrucomicrobia,37G7G@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
TH2_k127_2105441_0	583355.Caka_0724	4.959e-163	524.0	COG1219@1|root,COG1219@2|Bacteria,46SIK@74201|Verrucomicrobia,3K7MK@414999|Opitutae	414999|Opitutae	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
TH2_k127_2105441_2	1123073.KB899241_gene3100	9.623e-126	421.0	COG2017@1|root,COG2017@2|Bacteria,1RBJD@1224|Proteobacteria	1224|Proteobacteria	G	converts alpha-aldose to the beta-anomer	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_2105441_7	583355.Caka_2635	3.569e-51	190.0	COG3495@1|root,COG3495@2|Bacteria,46VE5@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function (DUF3299)	-	-	-	ko:K09950	-	-	-	-	ko00000	-	-	-	DUF3299
TH2_k127_2105441_1	768671.ThimaDRAFT_0949	5.281e-142	463.0	COG0577@1|root,COG0577@2|Bacteria,1MVN1@1224|Proteobacteria,1RNVN@1236|Gammaproteobacteria,1WXQU@135613|Chromatiales	135613|Chromatiales	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TH2_k127_2105441_5	2340.JV46_08550	2.607e-77	266.0	COG1136@1|root,COG1136@2|Bacteria,1RA1K@1224|Proteobacteria,1S275@1236|Gammaproteobacteria,1J63T@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TH2_k127_2105441_4	926550.CLDAP_12260	7.557e-86	309.0	COG1874@1|root,COG1874@2|Bacteria,2G604@200795|Chloroflexi	200795|Chloroflexi	G	PFAM Glycoside hydrolase family 42 domain protein	-	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_42,Glyco_hydro_42C,Glyco_hydro_42M
TH2_k127_2267162_1	497964.CfE428DRAFT_0960	0.0007437	51.0	2EWIC@1|root,33PWM@2|Bacteria,46TFG@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_2267162_0	404589.Anae109_0189	0.0	1102.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2YVGM@29|Myxococcales	28221|Deltaproteobacteria	I	CoA-substrate-specific enzyme activase	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
TH2_k127_2275841_2	1125863.JAFN01000001_gene2915	1.833e-162	522.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42MBF@68525|delta/epsilon subdivisions,2WJQ2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	PFAM Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TH2_k127_2275841_6	478741.JAFS01000002_gene310	6.054e-66	230.0	COG0163@1|root,COG0163@2|Bacteria,46V9E@74201|Verrucomicrobia,37GPM@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
TH2_k127_2275841_4	497964.CfE428DRAFT_5240	3.779e-136	440.0	COG2326@1|root,COG2326@2|Bacteria,46SAH@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
TH2_k127_2275841_0	794903.OPIT5_01440	1.11e-299	954.0	COG0383@1|root,COG0383@2|Bacteria	2|Bacteria	G	mannose metabolic process	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
TH2_k127_2275841_3	941449.dsx2_0569	1.488e-159	510.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,42MNJ@68525|delta/epsilon subdivisions,2WIZZ@28221|Deltaproteobacteria,2M8MT@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
TH2_k127_2275841_1	1232453.BAIF02000004_gene1559	8.104e-180	573.0	COG0407@1|root,COG0407@2|Bacteria,1V4WM@1239|Firmicutes,24ETW@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
TH2_k127_2275841_5	1408813.AYMG01000023_gene2065	6.877e-87	299.0	COG3669@1|root,COG3669@2|Bacteria,4NE74@976|Bacteroidetes,1IRC7@117747|Sphingobacteriia	976|Bacteroidetes	G	Alpha-L-fucosidase	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,F5_F8_type_C
TH2_k127_2275841_7	1454007.JAUG01000135_gene4079	1.658e-07	55.0	COG3669@1|root,COG3669@2|Bacteria,4NE74@976|Bacteroidetes,1IRC7@117747|Sphingobacteriia	976|Bacteroidetes	G	Alpha-L-fucosidase	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,F5_F8_type_C
TH2_k127_2312648_3	404380.Gbem_1268	1.511e-24	109.0	COG1959@1|root,COG1959@2|Bacteria,1MZ1C@1224|Proteobacteria,42SPF@68525|delta/epsilon subdivisions,2WPVC@28221|Deltaproteobacteria,43UWZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	transcriptional regulator, Rrf2 family	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
TH2_k127_2312648_2	794903.OPIT5_05785	7.129e-52	208.0	2EDTI@1|root,337NU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_2312648_0	497964.CfE428DRAFT_3745	1.485e-165	537.0	COG0761@1|root,COG0761@2|Bacteria,46SAR@74201|Verrucomicrobia	74201|Verrucomicrobia	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	lytB	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
TH2_k127_2312648_1	1210884.HG799462_gene7884	4.074e-124	419.0	COG0388@1|root,COG0388@2|Bacteria,2J4Q2@203682|Planctomycetes	203682|Planctomycetes	M	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
TH2_k127_2312648_4	1120980.JQKH01000070_gene1436	1.453e-15	82.0	COG1929@1|root,COG1929@2|Bacteria,1MVG9@1224|Proteobacteria,2VK3Q@28216|Betaproteobacteria,2KPCZ@206351|Neisseriales	206351|Neisseriales	G	Belongs to the glycerate kinase type-1 family	glxK	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
TH2_k127_2327557_5	330214.NIDE0964	1.449e-51	192.0	COG0642@1|root,COG2205@2|Bacteria	330214.NIDE0964|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_2327557_7	37659.JNLN01000001_gene2691	3.641e-05	51.0	COG0268@1|root,COG0268@2|Bacteria,1VEGX@1239|Firmicutes,24QNX@186801|Clostridia,36KIE@31979|Clostridiaceae	186801|Clostridia	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
TH2_k127_2327557_6	1156937.MFUM_270036	8.179e-21	99.0	2EM72@1|root,33EW9@2|Bacteria,46TAB@74201|Verrucomicrobia,37GMQ@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Lipopolysaccharide-assembly	-	-	-	-	-	-	-	-	-	-	-	-	LptE
TH2_k127_2327557_3	1156937.MFUM_270037	1.095e-62	228.0	COG1729@1|root,COG4105@1|root,COG1729@2|Bacteria,COG4105@2|Bacteria,46SYU@74201|Verrucomicrobia,37GE7@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Outer membrane lipoprotein	-	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	TPR_16,TPR_6,YfiO
TH2_k127_2327557_1	234267.Acid_5550	7.602e-89	302.0	COG4223@1|root,COG4223@2|Bacteria,3Y6G5@57723|Acidobacteria	57723|Acidobacteria	DZ	transferase activity, transferring acyl groups other than amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_2327557_2	667014.Thein_1135	1.653e-68	239.0	COG2231@1|root,COG2231@2|Bacteria,2GH00@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	endonuclease III	-	-	-	ko:K07457	-	-	-	-	ko00000	-	-	-	HhH-GPD
TH2_k127_2327557_0	1122918.KB907252_gene2913	3.396e-128	418.0	COG1082@1|root,COG1082@2|Bacteria,1TPJT@1239|Firmicutes,4H9KJ@91061|Bacilli,26STY@186822|Paenibacillaceae	91061|Bacilli	G	sugar phosphate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TH2_k127_2327557_4	525244.HMPREF0023_2106	3.061e-52	187.0	COG3738@1|root,COG3738@2|Bacteria,1RE1M@1224|Proteobacteria,1S44B@1236|Gammaproteobacteria,3NKTP@468|Moraxellaceae	1236|Gammaproteobacteria	S	Domain of unknown function (DUF1287)	yijF	-	-	ko:K09974	-	-	-	-	ko00000	-	-	-	DUF1287
TH2_k127_2342018_0	316274.Haur_2567	1.171e-105	358.0	COG1109@1|root,COG1109@2|Bacteria,2G5YP@200795|Chloroflexi,376E3@32061|Chloroflexia	32061|Chloroflexia	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TH2_k127_2342018_2	1380394.JADL01000008_gene3783	1.425e-57	213.0	COG3528@1|root,COG3528@2|Bacteria,1R601@1224|Proteobacteria,2U1IH@28211|Alphaproteobacteria,2JPW1@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2219
TH2_k127_2342018_1	497964.CfE428DRAFT_3980	7.3e-98	327.0	COG2908@1|root,COG2908@2|Bacteria,46U19@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
TH2_k127_2346425_0	1047013.AQSP01000138_gene1065	4.799e-33	136.0	COG1503@1|root,COG1503@2|Bacteria,2NQ54@2323|unclassified Bacteria	2|Bacteria	J	translation release factor activity	yocB	GO:0001666,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008150,GO:0009628,GO:0016020,GO:0030312,GO:0036293,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070482,GO:0071944	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	-
TH2_k127_2346425_1	1123242.JH636435_gene1894	2.226e-08	66.0	COG1668@1|root,COG1668@2|Bacteria	2|Bacteria	CP	transmembrane transport	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
TH2_k127_2362613_2	272123.Anacy_4208	4.648e-150	481.0	COG0167@1|root,COG0167@2|Bacteria,1G2B6@1117|Cyanobacteria,1HM34@1161|Nostocales	1117|Cyanobacteria	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
TH2_k127_2362613_0	395961.Cyan7425_4369	0.0	1716.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,1G2E2@1117|Cyanobacteria,3KGSH@43988|Cyanothece	1117|Cyanobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
TH2_k127_2362613_4	1288826.MSNKSG1_10083	3.087e-28	116.0	COG0298@1|root,COG0298@2|Bacteria	2|Bacteria	O	carbon dioxide binding	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
TH2_k127_2362613_1	1173028.ANKO01000017_gene228	4.512e-278	879.0	COG0068@1|root,COG0068@2|Bacteria,1G063@1117|Cyanobacteria,1H71F@1150|Oscillatoriales	1117|Cyanobacteria	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
TH2_k127_2362613_3	563192.HMPREF0179_01372	4.873e-69	242.0	COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,42MMJ@68525|delta/epsilon subdivisions,2WK7X@28221|Deltaproteobacteria,2M883@213115|Desulfovibrionales	28221|Deltaproteobacteria	KO	Hydrogenase accessory protein HypB	hypB	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
TH2_k127_2393102_1	717605.Theco_1139	3.517e-45	170.0	COG0352@1|root,COG2104@1|root,COG0352@2|Bacteria,COG2104@2|Bacteria,1V3ZR@1239|Firmicutes,4HH1E@91061|Bacilli,26UCZ@186822|Paenibacillaceae	91061|Bacilli	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
TH2_k127_2393102_0	1382359.JIAL01000001_gene2048	2.23e-131	430.0	COG4102@1|root,COG4102@2|Bacteria,3Y2YD@57723|Acidobacteria,2JI17@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TH2_k127_2442875_6	56780.SYN_00176	8.31e-87	311.0	COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,1NPFY@1224|Proteobacteria,42PRW@68525|delta/epsilon subdivisions,2WIMG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	homocysteine S-methyltransferase	metF-2	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0504	MTHFR,S-methyl_trans
TH2_k127_2442875_9	1121289.JHVL01000023_gene71	5.122e-52	194.0	COG1211@1|root,COG1211@2|Bacteria,1V3M7@1239|Firmicutes,248E6@186801|Clostridia,36EIP@31979|Clostridiaceae	186801|Clostridia	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS20335	IspD
TH2_k127_2442875_11	1121957.ATVL01000001_gene3512	1.856e-46	177.0	COG0398@1|root,COG0398@2|Bacteria,4NIT2@976|Bacteroidetes,47KFE@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function, DUF547	-	-	-	-	-	-	-	-	-	-	-	-	DUF547
TH2_k127_2442875_12	1121272.KB903253_gene6835	1.377e-41	174.0	COG5316@1|root,COG5316@2|Bacteria,2GN81@201174|Actinobacteria,4D9MM@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139,DUF4140
TH2_k127_2442875_7	497964.CfE428DRAFT_1881	6.42e-82	292.0	COG0815@1|root,COG0815@2|Bacteria,46SPW@74201|Verrucomicrobia	74201|Verrucomicrobia	M	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
TH2_k127_2442875_0	497964.CfE428DRAFT_4464	0.0	1172.0	COG0653@1|root,COG0653@2|Bacteria,46SJC@74201|Verrucomicrobia	74201|Verrucomicrobia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
TH2_k127_2442875_8	1121428.DESHY_110146___1	4.197e-61	217.0	COG0461@1|root,COG0461@2|Bacteria,1V1BZ@1239|Firmicutes,25CGM@186801|Clostridia,261GR@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
TH2_k127_2442875_5	316274.Haur_4675	1.549e-152	496.0	COG0166@1|root,COG0166@2|Bacteria,2G67J@200795|Chloroflexi,376N1@32061|Chloroflexia	32061|Chloroflexia	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
TH2_k127_2442875_2	497964.CfE428DRAFT_3497	4.079e-224	714.0	COG0465@1|root,COG0465@2|Bacteria,46SB7@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,Peptidase_M41
TH2_k127_2442875_16	1396141.BATP01000061_gene4550	1.755e-15	89.0	COG0265@1|root,COG0265@2|Bacteria,46WE6@74201|Verrucomicrobia,2IV0Y@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2
TH2_k127_2442875_17	452637.Oter_1653	4.023e-08	61.0	2C12Z@1|root,2ZUMU@2|Bacteria,46WS3@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_2442875_14	452637.Oter_1652	1.673e-34	138.0	COG1595@1|root,COG1595@2|Bacteria,46WAM@74201|Verrucomicrobia	74201|Verrucomicrobia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TH2_k127_2442875_15	264731.PRU_2783	7.413e-18	94.0	COG4977@1|root,COG4977@2|Bacteria,4PKX4@976|Bacteroidetes,2FNFD@200643|Bacteroidia	976|Bacteroidetes	K	transcriptional regulator (AraC family)	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18,HTH_AraC
TH2_k127_2442875_10	1303518.CCALI_01799	6.023e-48	186.0	COG5285@1|root,COG5285@2|Bacteria	2|Bacteria	Q	dioxygenase activity	-	-	-	ko:K18565	ko00332,ko01130,map00332,map01130	-	R10740,R10741,R10742	RC03267,RC03268,RC03269	ko00000,ko00001,ko01000	-	-	-	PhyH
TH2_k127_2442875_3	556261.HMPREF0240_04478	4.067e-184	584.0	28MXM@1|root,2Z8AT@2|Bacteria,1V0XI@1239|Firmicutes,24DIS@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_2442875_13	237368.SCABRO_01833	1.117e-37	158.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	2.7.8.20	ko:K01002,ko:K20534	ko01100,map01100	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	GT87,Glycos_transf_2
TH2_k127_2442875_4	382464.ABSI01000023_gene548	4.58e-158	510.0	COG0415@1|root,COG0415@2|Bacteria,46TVC@74201|Verrucomicrobia,2IU6D@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	DNA photolyase	-	-	-	-	-	-	-	-	-	-	-	-	DNA_photolyase,FAD_binding_7
TH2_k127_2442875_1	1227352.C173_25841	9.919e-234	736.0	COG0665@1|root,COG0665@2|Bacteria,1VRH3@1239|Firmicutes,4ISQR@91061|Bacilli,26SF8@186822|Paenibacillaceae	91061|Bacilli	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
TH2_k127_2442968_4	313628.LNTAR_16828	1.395e-132	436.0	COG3344@1|root,COG3344@2|Bacteria	2|Bacteria	L	reverse transcriptase	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,RVT_1
TH2_k127_2442968_2	1121440.AUMA01000005_gene2707	1.458e-140	457.0	COG2957@1|root,COG2957@2|Bacteria,1MX65@1224|Proteobacteria,42NAS@68525|delta/epsilon subdivisions,2WNAF@28221|Deltaproteobacteria,2M9I9@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Belongs to the agmatine deiminase family	aguA	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	PAD_porph
TH2_k127_2442968_0	378806.STAUR_6427	1.128e-254	832.0	COG1404@1|root,COG4412@1|root,COG1404@2|Bacteria,COG4412@2|Bacteria,1REF1@1224|Proteobacteria,42Q4N@68525|delta/epsilon subdivisions,2WS51@28221|Deltaproteobacteria,2YWNR@29|Myxococcales	28221|Deltaproteobacteria	O	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M6,Peptidase_S8
TH2_k127_2442968_7	1254432.SCE1572_21595	1.091e-57	231.0	COG2885@1|root,COG3391@1|root,COG5184@1|root,COG2885@2|Bacteria,COG3391@2|Bacteria,COG5184@2|Bacteria,1QUHA@1224|Proteobacteria,42VF6@68525|delta/epsilon subdivisions,2WR7F@28221|Deltaproteobacteria,2YV9Z@29|Myxococcales	28221|Deltaproteobacteria	DZ	Thrombospondin type 3 repeat	-	-	-	-	-	-	-	-	-	-	-	-	TSP_3
TH2_k127_2442968_5	1499967.BAYZ01000097_gene4350	9.492e-96	331.0	COG4826@1|root,COG4826@2|Bacteria,2NQVB@2323|unclassified Bacteria	2|Bacteria	O	SERine  Proteinase INhibitors	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
TH2_k127_2442968_3	240016.ABIZ01000001_gene1909	4.245e-138	449.0	COG0743@1|root,COG0743@2|Bacteria,46S90@74201|Verrucomicrobia,2ITI1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
TH2_k127_2442968_6	1156937.MFUM_700088	8.543e-71	258.0	COG0750@1|root,COG0750@2|Bacteria,46S9B@74201|Verrucomicrobia,37G4E@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	Peptidase family M50	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
TH2_k127_2442968_1	497964.CfE428DRAFT_4831	3.169e-206	661.0	COG0821@1|root,COG0821@2|Bacteria,46SEF@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
TH2_k127_2442968_9	526224.Bmur_0806	1.979e-20	96.0	COG1729@1|root,COG4232@1|root,COG1729@2|Bacteria,COG4232@2|Bacteria	2|Bacteria	CO	protein-disulfide reductase activity	-	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	LysM,TPR_16,TPR_6,Thioredoxin_7,YfiO
TH2_k127_2442968_10	491205.JARQ01000007_gene2951	1.808e-19	93.0	COG4232@1|root,COG4232@2|Bacteria,4NIXX@976|Bacteroidetes,1I0XW@117743|Flavobacteriia,3ZP0H@59732|Chryseobacterium	976|Bacteroidetes	CO	Thiol disulfide interchange protein	-	-	-	-	-	-	-	-	-	-	-	-	Thioredox_DsbH,Thioredoxin,Thioredoxin_2,Thioredoxin_7
TH2_k127_2442968_8	518766.Rmar_0039	8.413e-47	175.0	COG0494@1|root,COG0494@2|Bacteria,4NNGW@976|Bacteroidetes,1FK5D@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	L	NUDIX domain	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
TH2_k127_2472341_5	314230.DSM3645_17635	1.763e-60	239.0	COG0457@1|root,COG1729@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,2IZUV@203682|Planctomycetes	203682|Planctomycetes	H	Outer membrane lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
TH2_k127_2472341_3	1123070.KB899248_gene118	5.729e-127	415.0	COG0592@1|root,COG0592@2|Bacteria,46SPK@74201|Verrucomicrobia,2ITMH@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	-	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
TH2_k127_2472341_2	382464.ABSI01000010_gene3770	4.119e-147	481.0	COG0593@1|root,COG0593@2|Bacteria,46S6H@74201|Verrucomicrobia,2ITNP@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
TH2_k127_2472341_1	443143.GM18_3048	2.602e-218	686.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,42M7A@68525|delta/epsilon subdivisions,2WJ8P@28221|Deltaproteobacteria,43TAZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	PFAM glutamine synthetase catalytic region	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
TH2_k127_2472341_6	497964.CfE428DRAFT_6253	1.545e-51	185.0	COG0347@1|root,COG0347@2|Bacteria,46SW8@74201|Verrucomicrobia	74201|Verrucomicrobia	K	nitrogen regulatory protein P-II	-	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
TH2_k127_2472341_4	497964.CfE428DRAFT_3997	5.196e-79	287.0	COG0515@1|root,COG0515@2|Bacteria,46TX9@74201|Verrucomicrobia	74201|Verrucomicrobia	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,RicinB_lectin_2
TH2_k127_2472341_0	671143.DAMO_1933	0.0	1244.0	COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria	2|Bacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
TH2_k127_2487355_13	478741.JAFS01000002_gene933	2.741e-21	96.0	COG0763@1|root,COG0763@2|Bacteria,46SSG@74201|Verrucomicrobia,37GGI@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
TH2_k127_2487355_3	497964.CfE428DRAFT_0881	2.397e-95	323.0	COG0673@1|root,COG0673@2|Bacteria,46SAE@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Oxidoreductase family, NAD-binding Rossmann fold	mviM	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TH2_k127_2487355_6	1156937.MFUM_680010	6.762e-70	246.0	COG3494@1|root,COG3494@2|Bacteria,46SJ6@74201|Verrucomicrobia,37GEI@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function (DUF1009)	-	-	-	ko:K09949	-	-	-	-	ko00000	-	-	-	DUF1009
TH2_k127_2487355_10	583355.Caka_3025	4.243e-53	206.0	COG0739@1|root,COG0739@2|Bacteria,46V20@74201|Verrucomicrobia,3K74E@414999|Opitutae	414999|Opitutae	M	Peptidase M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TH2_k127_2487355_15	382464.ABSI01000005_gene1325	2.216e-05	53.0	2C6VV@1|root,2ZCPB@2|Bacteria,46WI3@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_2487355_8	1173025.GEI7407_0565	2.089e-61	239.0	COG1501@1|root,COG1501@2|Bacteria,1G3UD@1117|Cyanobacteria,1HADW@1150|Oscillatoriales	1117|Cyanobacteria	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31
TH2_k127_2487355_9	573413.Spirs_2325	1.048e-59	218.0	COG0637@1|root,COG0637@2|Bacteria,2J814@203691|Spirochaetes	203691|Spirochaetes	F	TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED	-	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	HAD_2,dCMP_cyt_deam_1
TH2_k127_2487355_5	1267535.KB906767_gene1277	8.22e-73	269.0	COG0109@1|root,COG0109@2|Bacteria,3Y3VI@57723|Acidobacteria,2JIRB@204432|Acidobacteriia	204432|Acidobacteriia	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
TH2_k127_2487355_0	204669.Acid345_2220	7.496e-106	356.0	COG1131@1|root,COG1131@2|Bacteria,3Y3I9@57723|Acidobacteria,2JIPJ@204432|Acidobacteriia	204432|Acidobacteriia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TH2_k127_2487355_2	290397.Adeh_0280	5.461e-97	323.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,42M3X@68525|delta/epsilon subdivisions,2WJDF@28221|Deltaproteobacteria,2YU4R@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
TH2_k127_2487355_7	240016.ABIZ01000001_gene737	5.05e-67	235.0	COG0264@1|root,COG0264@2|Bacteria,46SUK@74201|Verrucomicrobia,2IU52@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
TH2_k127_2487355_4	243276.TPANIC_0606	9.747e-78	270.0	COG0052@1|root,COG0052@2|Bacteria,2J5GZ@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
TH2_k127_2487355_12	1121428.DESHY_60198___1	2.107e-44	181.0	COG0344@1|root,COG0344@2|Bacteria,1VA3J@1239|Firmicutes,24JA2@186801|Clostridia,261ZE@186807|Peptococcaceae	186801|Clostridia	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
TH2_k127_2487355_1	1191523.MROS_1831	7.289e-104	347.0	COG0240@1|root,COG0240@2|Bacteria	2|Bacteria	I	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity	gpsA	GO:0003674,GO:0003824,GO:0004367,GO:0006072,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0046167,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901576	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
TH2_k127_2487355_11	794903.OPIT5_25465	8.821e-52	191.0	COG1595@1|root,COG1595@2|Bacteria,46U3X@74201|Verrucomicrobia,3K7M2@414999|Opitutae	414999|Opitutae	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TH2_k127_2487355_14	1288826.MSNKSG1_17571	1.253e-05	55.0	COG5662@1|root,COG5662@2|Bacteria,1NGBV@1224|Proteobacteria,1SGXN@1236|Gammaproteobacteria,46BR4@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
TH2_k127_2513945_3	383372.Rcas_1874	6.592e-139	452.0	COG3408@1|root,COG3408@2|Bacteria,2G7KB@200795|Chloroflexi,376HX@32061|Chloroflexia	32061|Chloroflexia	G	Bacterial alpha-L-rhamnosidase C-terminal domain	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
TH2_k127_2513945_0	1303518.CCALI_01615	5.577e-235	751.0	COG1657@1|root,COG1657@2|Bacteria	2|Bacteria	I	PFAM Prenyltransferase squalene oxidase	shc	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
TH2_k127_2513945_1	497964.CfE428DRAFT_6681	1.268e-191	609.0	COG0535@1|root,COG0535@2|Bacteria,46V38@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function (DUF3463)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Radical_SAM
TH2_k127_2513945_8	530564.Psta_1736	2.891e-20	100.0	COG0775@1|root,COG0775@2|Bacteria,2IZY2@203682|Planctomycetes	203682|Planctomycetes	F	phosphorylase	-	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
TH2_k127_2513945_4	96561.Dole_3181	8.148e-118	404.0	COG0038@1|root,COG0517@1|root,COG0569@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,COG0569@2|Bacteria,1MV4K@1224|Proteobacteria,42PJQ@68525|delta/epsilon subdivisions,2WKR4@28221|Deltaproteobacteria,2MPSV@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	iAF987.Gmet_3470	CBS,Voltage_CLC
TH2_k127_2513945_2	886293.Sinac_1523	1.981e-164	537.0	COG1164@1|root,COG1164@2|Bacteria,2IYTJ@203682|Planctomycetes	203682|Planctomycetes	E	TIGRFAM oligoendopeptidase, M3 family	-	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
TH2_k127_2513945_5	1232410.KI421427_gene1285	1.669e-101	348.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,42N1B@68525|delta/epsilon subdivisions,2WJWS@28221|Deltaproteobacteria,43UDG@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	PFAM FAD dependent oxidoreductase	glpD	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
TH2_k127_2513945_7	487796.Flav2ADRAFT_0413	7.413e-26	118.0	COG0584@1|root,COG0584@2|Bacteria,4NGNU@976|Bacteroidetes,1HYHS@117743|Flavobacteriia	976|Bacteroidetes	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
TH2_k127_2513945_6	497964.CfE428DRAFT_6397	1.377e-26	115.0	2EJEW@1|root,30R71@2|Bacteria,46WM6@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_251779_1	1170562.Cal6303_1215	2.347e-53	195.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1FZWQ@1117|Cyanobacteria,1HKIQ@1161|Nostocales	1117|Cyanobacteria	KLT	PFAM Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,Pkinase
TH2_k127_251779_0	1232410.KI421415_gene3033	1.71e-108	376.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,42ND6@68525|delta/epsilon subdivisions,2WIJS@28221|Deltaproteobacteria,43T92@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
TH2_k127_2584062_10	686340.Metal_0299	0.0001648	50.0	28HY3@1|root,2Z83I@2|Bacteria,1R5P3@1224|Proteobacteria,1S1M3@1236|Gammaproteobacteria,1XDZM@135618|Methylococcales	135618|Methylococcales	S	phosphoenolpyruvate carboxykinase (diphosphate) activity	-	-	4.1.1.38	ko:K20370	ko00620,ko01100,map00620,map01100	-	R00346	RC02741	ko00000,ko00001,ko01000	-	-	-	-
TH2_k127_2584062_0	378806.STAUR_3269	5.648e-127	445.0	COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,1MU3S@1224|Proteobacteria,42Q3Z@68525|delta/epsilon subdivisions,2WJPC@28221|Deltaproteobacteria,2YUCY@29|Myxococcales	28221|Deltaproteobacteria	O	PFAM peptidase S8 and S53 subtilisin kexin sedolisin	-	-	3.4.21.66	ko:K08651	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	Big_2,CUB,He_PIG,Peptidase_S8
TH2_k127_2584062_7	1521187.JPIM01000126_gene240	2.072e-20	108.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	3.4.21.10	ko:K01317	-	-	-	-	ko00000,ko01000,ko01002,ko04131	-	-	-	CARDB,DUF5011,HYR,Laminin_G_3,VCBS
TH2_k127_2584062_8	1123242.JH636434_gene4264	4.563e-07	64.0	COG1196@1|root,COG1196@2|Bacteria,2IYCW@203682|Planctomycetes	203682|Planctomycetes	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_2584062_9	1089550.ATTH01000001_gene265	1.396e-06	62.0	COG2010@1|root,COG2755@1|root,COG3210@1|root,COG2010@2|Bacteria,COG2755@2|Bacteria,COG3210@2|Bacteria,4PND6@976|Bacteroidetes,1FJRB@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_2584062_2	497964.CfE428DRAFT_4839	8.92e-97	325.0	COG0568@1|root,COG0568@2|Bacteria,46SJ8@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TH2_k127_2584062_6	489825.LYNGBM3L_21160	4.305e-24	115.0	COG1216@1|root,COG1216@2|Bacteria,1FZX3@1117|Cyanobacteria,1HA1F@1150|Oscillatoriales	2|Bacteria	S	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	GlcNAc,Glyco_tranf_2_3,Glycos_transf_2
TH2_k127_2584062_4	179408.Osc7112_4372	4.517e-72	257.0	COG0463@1|root,COG2227@1|root,COG4122@1|root,COG0463@2|Bacteria,COG2227@2|Bacteria,COG4122@2|Bacteria,1G4MU@1117|Cyanobacteria,1HAKA@1150|Oscillatoriales	1117|Cyanobacteria	M	Methyltransferase domain	-	-	-	ko:K05303	-	-	-	-	ko00000,ko01000	-	-	-	Glycos_transf_2,Methyltransf_23,Methyltransf_24,TylF
TH2_k127_2584062_1	489825.LYNGBM3L_21110	2.936e-106	358.0	COG1215@1|root,COG1215@2|Bacteria,1GQTA@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TH2_k127_2584062_5	65093.PCC7418_0966	9.838e-44	179.0	COG0438@1|root,COG0438@2|Bacteria,1G0Z5@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TH2_k127_2584062_3	489825.LYNGBM3L_21190	8.951e-95	321.0	COG0438@1|root,COG0438@2|Bacteria,1GC2Y@1117|Cyanobacteria	1117|Cyanobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_2591304_3	411473.RUMCAL_00724	2.807e-08	57.0	COG0413@1|root,COG0413@2|Bacteria,1TPZA@1239|Firmicutes,248RR@186801|Clostridia,3WHXQ@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
TH2_k127_2591304_1	1156937.MFUM_260026	2.426e-31	141.0	COG0801@1|root,COG0801@2|Bacteria,46T2Z@74201|Verrucomicrobia,37H9P@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	H	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
TH2_k127_2591304_4	1121004.ATVC01000050_gene907	0.0001434	54.0	COG4103@1|root,COG4103@2|Bacteria,1R9A4@1224|Proteobacteria,2VIV8@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tellurite resistance protein TerB	-	-	-	-	-	-	-	-	-	-	-	-	TerB
TH2_k127_2591304_0	385682.AFSL01000060_gene1832	1.894e-179	576.0	COG0569@1|root,COG2985@1|root,COG0569@2|Bacteria,COG2985@2|Bacteria,4NEBW@976|Bacteroidetes,2FMDF@200643|Bacteroidia,3XJTE@558415|Marinilabiliaceae	976|Bacteroidetes	P	Predicted Permease Membrane Region	-	-	-	ko:K07085	-	-	-	-	ko00000	2.A.81	-	-	Asp-Al_Ex,TrkA_C
TH2_k127_2591304_2	1056820.KB900631_gene2368	5.449e-24	105.0	COG1215@1|root,COG1215@2|Bacteria,1PCBQ@1224|Proteobacteria,1SX97@1236|Gammaproteobacteria,2PP76@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	M	Glycosyl transferase family 21	-	-	2.4.1.80	ko:K00720	ko00600,ko01100,map00600,map01100	M00066	R01497	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000	4.D.1.4	GT21	-	Glyco_transf_21
TH2_k127_2596082_6	1210884.HG799466_gene12533	1.517e-37	153.0	COG1595@1|root,COG1595@2|Bacteria,2J2WP@203682|Planctomycetes	2|Bacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	PD40,Sigma70_r2,Sigma70_r4_2
TH2_k127_2596082_0	497964.CfE428DRAFT_2061	4.273e-207	657.0	COG0138@1|root,COG0138@2|Bacteria,46S5H@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
TH2_k127_2596082_2	378806.STAUR_8051	4.981e-125	412.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WIMF@28221|Deltaproteobacteria,2YYX2@29|Myxococcales	28221|Deltaproteobacteria	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
TH2_k127_2596082_4	1042877.GQS_03005	2.548e-57	205.0	COG0537@1|root,arCOG00419@2157|Archaea,2XWGT@28890|Euryarchaeota,242M1@183968|Thermococci	183968|Thermococci	F	Hit family	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
TH2_k127_2596082_5	452637.Oter_2046	7.681e-44	173.0	COG0466@1|root,COG0466@2|Bacteria,46WE2@74201|Verrucomicrobia,3K9NW@414999|Opitutae	414999|Opitutae	O	PFAM peptidase S16 lon domain protein	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
TH2_k127_2596082_3	237368.SCABRO_00762	1.864e-71	258.0	28I4Y@1|root,2Z88D@2|Bacteria,2J2FV@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_2596082_1	1313304.CALK_2071	1.741e-166	530.0	COG0473@1|root,COG0473@2|Bacteria	2|Bacteria	CE	3-isopropylmalate dehydrogenase activity	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044464,GO:0055114	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TH2_k127_2596082_7	1396141.BATP01000047_gene3944	1.65e-27	115.0	COG1943@1|root,COG1943@2|Bacteria,46X0P@74201|Verrucomicrobia,2IVW1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_2596082_8	1122917.KB899662_gene2296	1.39e-07	53.0	COG0673@1|root,COG0673@2|Bacteria,1USVA@1239|Firmicutes,4HDVM@91061|Bacilli,26VU3@186822|Paenibacillaceae	91061|Bacilli	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TH2_k127_2623477_0	661478.OP10G_1822	3.519e-79	303.0	COG0577@1|root,COG2234@1|root,COG0577@2|Bacteria,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
TH2_k127_2623477_2	666686.B1NLA3E_10835	0.0001112	57.0	COG0791@1|root,COG1388@1|root,COG0791@2|Bacteria,COG1388@2|Bacteria,1TP24@1239|Firmicutes,4HA77@91061|Bacilli,1ZCHY@1386|Bacillus	91061|Bacilli	M	COG1388 FOG LysM repeat	-	-	-	ko:K19223,ko:K19224,ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	CBM50	-	LysM,NLPC_P60,PG_binding_1
TH2_k127_2623477_1	1303518.CCALI_00994	1.408e-28	134.0	28HQ2@1|root,2Z7XV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_2628817_2	794903.OPIT5_02510	7.886e-10	59.0	COG4974@1|root,COG4974@2|Bacteria,46UB9@74201|Verrucomicrobia,3K9DD@414999|Opitutae	414999|Opitutae	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
TH2_k127_2628817_1	502025.Hoch_3411	7.483e-120	397.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,42M67@68525|delta/epsilon subdivisions,2WJQX@28221|Deltaproteobacteria,2YY2Q@29|Myxococcales	28221|Deltaproteobacteria	H	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
TH2_k127_2628817_0	237368.SCABRO_01577	1.461e-198	629.0	COG0498@1|root,COG0498@2|Bacteria,2IXKE@203682|Planctomycetes	203682|Planctomycetes	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TH2_k127_2643089_0	314230.DSM3645_06639	0.0	1197.0	COG2609@1|root,COG2609@2|Bacteria,2IXXY@203682|Planctomycetes	203682|Planctomycetes	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
TH2_k127_2643089_3	1210884.HG799462_gene7872	5.167e-54	200.0	COG0095@1|root,COG0095@2|Bacteria,2J0D8@203682|Planctomycetes	203682|Planctomycetes	H	PFAM Biotin lipoate A B protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
TH2_k127_2643089_1	794903.OPIT5_00625	7.836e-114	379.0	COG3842@1|root,COG3842@2|Bacteria,46SFH@74201|Verrucomicrobia,3K7SS@414999|Opitutae	414999|Opitutae	P	Belongs to the ABC transporter superfamily	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran
TH2_k127_2643089_2	497964.CfE428DRAFT_5470	1.662e-61	228.0	COG2204@1|root,COG2204@2|Bacteria,46VVS@74201|Verrucomicrobia	74201|Verrucomicrobia	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TH2_k127_2643089_4	330214.NIDE3592	1.129e-10	65.0	COG2067@1|root,COG2067@2|Bacteria	2|Bacteria	I	long-chain fatty acid transporting porin activity	fadL	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
TH2_k127_27371_6	443143.GM18_1481	4.661e-15	80.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,42MP1@68525|delta/epsilon subdivisions,2WJPD@28221|Deltaproteobacteria,43TEF@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	response regulator	phoB	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TH2_k127_27371_1	443254.Marpi_1865	4.309e-319	1002.0	COG0060@1|root,COG0060@2|Bacteria,2GC5I@200918|Thermotogae	200918|Thermotogae	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
TH2_k127_27371_5	452637.Oter_2692	1.044e-33	138.0	COG1734@1|root,COG1734@2|Bacteria,46SVY@74201|Verrucomicrobia,3K75N@414999|Opitutae	414999|Opitutae	K	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
TH2_k127_27371_3	794903.OPIT5_05580	1.599e-38	149.0	COG0597@1|root,COG0597@2|Bacteria,46TCC@74201|Verrucomicrobia,3K87P@414999|Opitutae	414999|Opitutae	M	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
TH2_k127_27371_0	497964.CfE428DRAFT_5976	0.0	1135.0	COG0542@1|root,COG0542@2|Bacteria,46S4S@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
TH2_k127_27371_7	552396.HMPREF0863_04127	7.877e-10	70.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	-	-	-	-	-	-	-	-	-	-	FHA
TH2_k127_27371_2	497964.CfE428DRAFT_4728	2.816e-49	186.0	COG0463@1|root,COG0463@2|Bacteria,46UW3@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TH2_k127_27371_8	118166.JH976538_gene5418	0.0008473	52.0	COG1807@1|root,COG1807@2|Bacteria,1G06T@1117|Cyanobacteria,1H7KG@1150|Oscillatoriales	1117|Cyanobacteria	M	4-amino-4-deoxy-L-arabinose transferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
TH2_k127_27371_4	1403819.BATR01000092_gene2687	1.15e-37	147.0	COG1510@1|root,COG1510@2|Bacteria,46VTX@74201|Verrucomicrobia,2IW6I@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	regulation of RNA biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_2748294_1	118161.KB235922_gene5825	9.096e-34	139.0	COG5433@1|root,COG5433@2|Bacteria,1G0VN@1117|Cyanobacteria,3VJBK@52604|Pleurocapsales	1117|Cyanobacteria	L	DDE_Tnp_1-associated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
TH2_k127_2748294_3	452637.Oter_2155	4.357e-08	61.0	COG2373@1|root,COG2373@2|Bacteria,46U24@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Alpha-2-macroglobulin family	-	-	-	-	-	-	-	-	-	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,Thiol-ester_cl
TH2_k127_2748294_2	641107.CDLVIII_1735	1.759e-18	98.0	COG1586@1|root,COG1748@1|root,COG1586@2|Bacteria,COG1748@2|Bacteria,1UZ0U@1239|Firmicutes	1239|Firmicutes	E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_NADP
TH2_k127_2748294_0	926569.ANT_01050	1.449e-109	359.0	COG0240@1|root,COG0240@2|Bacteria,2G6HJ@200795|Chloroflexi	200795|Chloroflexi	C	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain	-	-	1.5.1.28	ko:K04940	-	-	-	-	ko00000,ko01000	-	-	-	NAD_Gly3P_dh_N,Octopine_DH
TH2_k127_2757905_0	1121403.AUCV01000020_gene3140	3.171e-65	254.0	COG0577@1|root,COG2234@1|root,COG0577@2|Bacteria,COG2234@2|Bacteria,1MVYE@1224|Proteobacteria,42PKN@68525|delta/epsilon subdivisions,2WIWP@28221|Deltaproteobacteria,2MIQI@213118|Desulfobacterales	28221|Deltaproteobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,PA,Peptidase_M28
TH2_k127_283152_2	1274374.CBLK010000060_gene567	0.0001317	49.0	COG3250@1|root,COG3250@2|Bacteria,1TS96@1239|Firmicutes,4HBKW@91061|Bacilli,26S7W@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the glycosyl hydrolase 2 family	bmnA	-	3.2.1.25	ko:K01192	ko00511,ko04142,map00511,map04142	-	-	-	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
TH2_k127_283152_1	497964.CfE428DRAFT_2283	7.666e-28	115.0	COG2331@1|root,COG2331@2|Bacteria,46T2S@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
TH2_k127_283152_0	497964.CfE428DRAFT_1386	2.408e-218	694.0	COG0525@1|root,COG0525@2|Bacteria,46SGP@74201|Verrucomicrobia	74201|Verrucomicrobia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
TH2_k127_2834904_2	269797.Mbar_A3123	1.27e-67	234.0	COG1203@1|root,arCOG01444@2157|Archaea,2XUY8@28890|Euryarchaeota,2NBCC@224756|Methanomicrobia	224756|Methanomicrobia	V	helicase superfamily c-terminal domain	-	-	-	ko:K07012	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DEAD,Helicase_C
TH2_k127_2834904_4	58123.JOFJ01000017_gene4162	1.022e-56	203.0	COG0503@1|root,COG0503@2|Bacteria,2IM7C@201174|Actinobacteria,4EIYA@85012|Streptosporangiales	201174|Actinobacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	GO:0003674,GO:0003824,GO:0003999,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006144,GO:0006168,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
TH2_k127_2834904_0	240016.ABIZ01000001_gene1452	5.222e-143	464.0	COG1454@1|root,COG1454@2|Bacteria,46TD9@74201|Verrucomicrobia,2IUNH@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Iron-containing alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
TH2_k127_2834904_3	211165.AJLN01000066_gene4475	5.172e-59	215.0	COG0561@1|root,COG0561@2|Bacteria,1GDI4@1117|Cyanobacteria	1117|Cyanobacteria	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
TH2_k127_2834904_1	1304880.JAGB01000003_gene1278	5.872e-92	309.0	COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia	186801|Clostridia	G	hydrolase, family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
TH2_k127_28525_14	180332.JTGN01000016_gene977	1.237e-16	80.0	2DP8N@1|root,3311E@2|Bacteria,1VG5U@1239|Firmicutes,24S4D@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_28525_11	313628.LNTAR_03694	1.88e-29	126.0	COG0710@1|root,COG0710@2|Bacteria	2|Bacteria	E	3-dehydroquinate dehydratase activity	aroD	GO:0000166,GO:0003674,GO:0003824,GO:0003855,GO:0004764,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006725,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009712,GO:0009713,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018958,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0042537,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046189,GO:0046278,GO:0046279,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1901615,GO:1901617	1.1.1.25,4.2.1.10	ko:K03785,ko:K13832	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413,R03084	RC00206,RC00848	ko00000,ko00001,ko00002,ko01000	-	-	iEC042_1314.EC042_1860	DHquinase_I,Shikimate_DH,Shikimate_dh_N
TH2_k127_28525_7	756272.Plabr_2286	7.413e-52	199.0	COG1657@1|root,COG1657@2|Bacteria,2IZ5Q@203682|Planctomycetes	203682|Planctomycetes	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans
TH2_k127_28525_0	880072.Desac_2709	3.17e-321	993.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,42NYT@68525|delta/epsilon subdivisions,2WIM3@28221|Deltaproteobacteria,2MQVI@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
TH2_k127_28525_12	1120950.KB892746_gene3467	1.52e-28	127.0	COG4977@1|root,COG4977@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TH2_k127_28525_3	1303518.CCALI_01282	7.647e-103	342.0	COG5285@1|root,COG5285@2|Bacteria	2|Bacteria	Q	dioxygenase activity	phyH	-	1.14.11.18	ko:K00477,ko:K18565	ko00332,ko01130,ko04146,map00332,map01130,map04146	-	R10740,R10741,R10742	RC03267,RC03268,RC03269	ko00000,ko00001,ko01000	-	-	-	PhyH
TH2_k127_28525_2	240016.ABIZ01000001_gene4007	1.647e-158	517.0	COG1219@1|root,COG1219@2|Bacteria,46U7E@74201|Verrucomicrobia,2IVDM@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	AAA domain (Cdc48 subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_2,ClpB_D2-small
TH2_k127_28525_15	290317.Cpha266_0900	3.17e-11	65.0	COG1262@1|root,COG1262@2|Bacteria,1FFBZ@1090|Chlorobi	1090|Chlorobi	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
TH2_k127_28525_17	1121403.AUCV01000031_gene2857	1.888e-06	50.0	29GCA@1|root,303A5@2|Bacteria,1NC46@1224|Proteobacteria,431AV@68525|delta/epsilon subdivisions,2WWN5@28221|Deltaproteobacteria,2MNY5@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_28525_6	1121403.AUCV01000031_gene2857	3.213e-52	188.0	29GCA@1|root,303A5@2|Bacteria,1NC46@1224|Proteobacteria,431AV@68525|delta/epsilon subdivisions,2WWN5@28221|Deltaproteobacteria,2MNY5@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_28525_8	1121403.AUCV01000031_gene2857	1.367e-40	156.0	29GCA@1|root,303A5@2|Bacteria,1NC46@1224|Proteobacteria,431AV@68525|delta/epsilon subdivisions,2WWN5@28221|Deltaproteobacteria,2MNY5@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_28525_1	344747.PM8797T_21553	1.544e-169	542.0	COG0535@1|root,COG0535@2|Bacteria,2IX8N@203682|Planctomycetes	203682|Planctomycetes	S	enzyme of the MoaA nifB pqqE family	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
TH2_k127_28525_10	1403819.BATR01000187_gene6437	6.36e-34	141.0	COG0509@1|root,COG0509@2|Bacteria,46WCE@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Glycine cleavage H-protein	-	-	-	-	-	-	-	-	-	-	-	-	GCV_H
TH2_k127_28525_9	497964.CfE428DRAFT_6361	5.34e-39	148.0	2FICZ@1|root,34A57@2|Bacteria,46W7Z@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_28525_4	497964.CfE428DRAFT_6362	2.32e-94	333.0	COG1146@1|root,COG1146@2|Bacteria,46TI2@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_28525_5	1382356.JQMP01000001_gene1154	7.819e-76	260.0	COG1573@1|root,COG1573@2|Bacteria,2G8DF@200795|Chloroflexi,27YTA@189775|Thermomicrobia	189775|Thermomicrobia	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TH2_k127_28525_13	1121929.KB898663_gene828	1.154e-24	106.0	COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,4HBDB@91061|Bacilli	91061|Bacilli	G	Belongs to the glycosyl hydrolase 3 family	nagZ	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4309,Glyco_hydro_3
TH2_k127_286907_10	888727.HMPREF9092_1642	8.735e-23	102.0	2BPEU@1|root,32I71@2|Bacteria,1VDVA@1239|Firmicutes,25BDW@186801|Clostridia	186801|Clostridia	S	HIRAN	-	-	-	-	-	-	-	-	-	-	-	-	HIRAN
TH2_k127_286907_8	1080067.BAZH01000014_gene437	9.949e-56	197.0	COG1917@1|root,COG1917@2|Bacteria,1RHHY@1224|Proteobacteria	1224|Proteobacteria	S	Cupin 2, conserved barrel	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,Cupin_3
TH2_k127_286907_9	595460.RRSWK_00514	1.177e-27	129.0	COG5429@1|root,COG5429@2|Bacteria,2J0V9@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1223)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1223
TH2_k127_286907_5	338966.Ppro_1292	2.667e-61	220.0	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,42QQ3@68525|delta/epsilon subdivisions,2WNPH@28221|Deltaproteobacteria,43U0C@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
TH2_k127_286907_1	1396141.BATP01000023_gene582	2.136e-179	573.0	COG0133@1|root,COG0133@2|Bacteria,46SHR@74201|Verrucomicrobia,2ITRB@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TH2_k127_286907_11	497964.CfE428DRAFT_2605	1.589e-22	99.0	2E99J@1|root,333HQ@2|Bacteria,46T77@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4032
TH2_k127_286907_6	335541.Swol_1285	9.084e-57	204.0	COG2065@1|root,COG2065@2|Bacteria,1V3GV@1239|Firmicutes,24FQD@186801|Clostridia,42JUY@68298|Syntrophomonadaceae	186801|Clostridia	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	iHN637.CLJU_RS05275	Pribosyltran
TH2_k127_286907_4	497964.CfE428DRAFT_2607	3.555e-140	452.0	COG0540@1|root,COG0540@2|Bacteria,46S9E@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
TH2_k127_286907_2	497964.CfE428DRAFT_2609	2.696e-175	563.0	COG0044@1|root,COG0044@2|Bacteria,46S78@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
TH2_k127_286907_3	1403819.BATR01000184_gene6355	2.392e-147	475.0	COG0505@1|root,COG0505@2|Bacteria,46TDX@74201|Verrucomicrobia,2ITTA@203494|Verrucomicrobiae	203494|Verrucomicrobiae	F	Carbamoyl-phosphate synthase small chain, CPSase domain	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
TH2_k127_286907_0	519989.ECTPHS_08773	1.29e-213	681.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,1WXBH@135613|Chromatiales	135613|Chromatiales	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
TH2_k127_286907_7	545243.BAEV01000070_gene2680	9.402e-57	206.0	COG0486@1|root,COG0486@2|Bacteria,1TPJF@1239|Firmicutes,248A9@186801|Clostridia,36ECR@31979|Clostridiaceae	186801|Clostridia	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
TH2_k127_292864_7	44454.NF84_23275	3.797e-28	117.0	COG0286@1|root,COG0286@2|Bacteria,2GP6Y@201174|Actinobacteria,237RT@1762|Mycobacteriaceae	201174|Actinobacteria	V	Putative RNA methylase family UPF0020	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HSDR_N_2,HsdM_N,N6_Mtase
TH2_k127_292864_5	909663.KI867150_gene2901	3.849e-58	207.0	COG4185@1|root,COG4185@2|Bacteria,1RFDC@1224|Proteobacteria,42TT0@68525|delta/epsilon subdivisions,2WQEY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Zeta_toxin
TH2_k127_292864_0	247490.KSU1_C0672	1.27e-321	1002.0	COG4096@1|root,COG4096@2|Bacteria,2IXTV@203682|Planctomycetes	203682|Planctomycetes	L	EcoEI R protein C-terminal	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	EcoEI_R_C,Helicase_C,ResIII
TH2_k127_292864_4	497964.CfE428DRAFT_0735	8.448e-76	264.0	COG0637@1|root,COG0637@2|Bacteria,46SWS@74201|Verrucomicrobia	74201|Verrucomicrobia	S	HAD-hyrolase-like	-	-	5.4.2.6	ko:K01838	ko00500,map00500	-	R02728,R11310	RC00408	ko00000,ko00001,ko01000	-	-	-	HAD_2
TH2_k127_292864_1	1173028.ANKO01000044_gene739	4.244e-123	401.0	COG1893@1|root,COG1893@2|Bacteria,1G2H9@1117|Cyanobacteria,1H7Y1@1150|Oscillatoriales	1117|Cyanobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
TH2_k127_292864_8	1403819.BATR01000118_gene4114	1.734e-06	56.0	2E4YE@1|root,32ZSA@2|Bacteria,46WYD@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_292864_6	404589.Anae109_4420	1.352e-39	169.0	COG2304@1|root,COG2304@2|Bacteria,1NX8F@1224|Proteobacteria,430QD@68525|delta/epsilon subdivisions,2WVNR@28221|Deltaproteobacteria,2YW4W@29|Myxococcales	28221|Deltaproteobacteria	S	Aerotolerance regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
TH2_k127_292864_3	880073.Calab_3696	3.667e-77	268.0	COG1721@1|root,COG1721@2|Bacteria,2NP6B@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
TH2_k127_292864_2	390874.Tpet_1677	3.903e-87	318.0	COG0747@1|root,COG0747@2|Bacteria,2GCNZ@200918|Thermotogae	200918|Thermotogae	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TH2_k127_292864_9	1121033.AUCF01000003_gene3331	1.35e-05	59.0	COG0601@1|root,COG0601@2|Bacteria,1MWXF@1224|Proteobacteria,2TR7C@28211|Alphaproteobacteria,2JQ7B@204441|Rhodospirillales	204441|Rhodospirillales	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TH2_k127_2947324_8	794903.OPIT5_15420	2.65e-38	145.0	COG1082@1|root,COG1082@2|Bacteria,46XIH@74201|Verrucomicrobia,3K8KZ@414999|Opitutae	414999|Opitutae	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TH2_k127_2947324_4	743719.PaelaDRAFT_3002	1.562e-70	250.0	COG1082@1|root,COG1082@2|Bacteria,1UYRD@1239|Firmicutes,4HEHD@91061|Bacilli,26XRE@186822|Paenibacillaceae	91061|Bacilli	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TH2_k127_2947324_10	481448.Minf_1852	1.409e-12	69.0	COG0828@1|root,COG0828@2|Bacteria,46WP6@74201|Verrucomicrobia,37HBT@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	J	Ribosomal protein S21	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
TH2_k127_2947324_9	478741.JAFS01000002_gene473	7.374e-31	135.0	COG0392@1|root,COG0392@2|Bacteria,46T31@74201|Verrucomicrobia,37GPN@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
TH2_k127_2947324_6	240016.ABIZ01000001_gene1542	8.099e-50	193.0	COG0526@1|root,COG0526@2|Bacteria,46VHM@74201|Verrucomicrobia,2IVZA@203494|Verrucomicrobiae	203494|Verrucomicrobiae	CO	SCO1/SenC	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TH2_k127_2947324_2	1123261.AXDW01000007_gene2321	4.858e-86	292.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RSA2@1236|Gammaproteobacteria,1X3CK@135614|Xanthomonadales	135614|Xanthomonadales	V	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TH2_k127_2947324_3	903818.KI912268_gene3203	1.866e-73	265.0	COG0577@1|root,COG0577@2|Bacteria,3Y4MY@57723|Acidobacteria	57723|Acidobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TH2_k127_2947324_1	1267535.KB906767_gene3518	6.756e-99	336.0	COG0577@1|root,COG0577@2|Bacteria,3Y4C7@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
TH2_k127_2947324_7	1340493.JNIF01000003_gene2502	4.168e-46	186.0	COG0845@1|root,COG0845@2|Bacteria,3Y50Z@57723|Acidobacteria	57723|Acidobacteria	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
TH2_k127_2947324_11	794903.OPIT5_13075	1.512e-11	67.0	COG0861@1|root,COG1253@1|root,COG0861@2|Bacteria,COG1253@2|Bacteria,46TS9@74201|Verrucomicrobia,3K8X2@414999|Opitutae	414999|Opitutae	P	membrane	-	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
TH2_k127_2947324_5	1403819.BATR01000120_gene4247	2.529e-58	212.0	COG3932@1|root,COG3932@2|Bacteria,46T8A@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Exopolysaccharide synthesis, ExoD	-	-	-	-	-	-	-	-	-	-	-	-	ExoD
TH2_k127_2947324_0	1380391.JIAS01000014_gene2298	8.107e-211	669.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,2JPCQ@204441|Rhodospirillales	204441|Rhodospirillales	P	COG2217 Cation transport ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
TH2_k127_301978_15	643562.Daes_2562	4.682e-15	79.0	COG3464@1|root,COG3464@2|Bacteria,1MV5J@1224|Proteobacteria,42M93@68525|delta/epsilon subdivisions,2WK5I@28221|Deltaproteobacteria,2MBEI@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM Transposase, IS204 IS1001 IS1096 IS1165	-	-	-	ko:K07485	-	-	-	-	ko00000	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
TH2_k127_301978_6	643562.Daes_0386	5.772e-85	296.0	COG3464@1|root,COG3464@2|Bacteria,1MV5J@1224|Proteobacteria,42M93@68525|delta/epsilon subdivisions,2WK5I@28221|Deltaproteobacteria,2MBEI@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM Transposase, IS204 IS1001 IS1096 IS1165	-	-	-	ko:K07485	-	-	-	-	ko00000	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
TH2_k127_301978_11	497964.CfE428DRAFT_1788	3.196e-38	153.0	COG1011@1|root,COG1011@2|Bacteria,46T57@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
TH2_k127_301978_4	555079.Toce_0685	5.804e-105	356.0	COG0285@1|root,COG0285@2|Bacteria,1TPX5@1239|Firmicutes,247PC@186801|Clostridia,42EM6@68295|Thermoanaerobacterales	186801|Clostridia	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
TH2_k127_301978_2	497964.CfE428DRAFT_2029	3.167e-108	358.0	COG0777@1|root,COG0777@2|Bacteria,46SI0@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
TH2_k127_301978_10	497964.CfE428DRAFT_2030	2.608e-45	179.0	COG1040@1|root,COG1040@2|Bacteria,46T0D@74201|Verrucomicrobia	74201|Verrucomicrobia	S	competence protein	comFC	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
TH2_k127_301978_17	247490.KSU1_D0617	7.176e-13	79.0	COG1266@1|root,COG1266@2|Bacteria,2J329@203682|Planctomycetes	203682|Planctomycetes	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
TH2_k127_301978_7	382464.ABSI01000020_gene176	2.291e-83	306.0	COG1450@1|root,COG1450@2|Bacteria,46UJ6@74201|Verrucomicrobia,2IU06@203494|Verrucomicrobiae	203494|Verrucomicrobiae	NU	Bacterial type II/III secretion system short domain	-	-	-	-	-	-	-	-	-	-	-	-	Secretin,Secretin_N
TH2_k127_301978_21	314345.SPV1_08111	5.266e-05	52.0	COG3167@1|root,COG3167@2|Bacteria	2|Bacteria	NU	carbon utilization	pilO	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
TH2_k127_301978_18	1111069.TCCBUS3UF1_6360	2.388e-09	70.0	COG4972@1|root,COG4972@2|Bacteria,1WJKT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	NU	TIGRFAM type IV pilus assembly protein PilM	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
TH2_k127_301978_12	671143.DAMO_2483	6.033e-33	144.0	COG3156@1|root,COG3156@2|Bacteria	2|Bacteria	U	protein secretion	-	-	-	ko:K02460	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSK
TH2_k127_301978_20	1283300.ATXB01000001_gene1942	4.963e-05	54.0	COG4968@1|root,COG4968@2|Bacteria,1NAXM@1224|Proteobacteria,1SGAU@1236|Gammaproteobacteria,1XF95@135618|Methylococcales	135618|Methylococcales	U	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02459	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
TH2_k127_301978_19	794903.OPIT5_25375	6.607e-06	56.0	2FHV3@1|root,349N9@2|Bacteria,46W6J@74201|Verrucomicrobia,3K8DZ@414999|Opitutae	414999|Opitutae	-	-	-	-	-	ko:K02457	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GspH,N_methyl
TH2_k127_301978_13	278957.ABEA03000161_gene138	5.808e-27	115.0	COG2165@1|root,COG2165@2|Bacteria,46W6A@74201|Verrucomicrobia,3K883@414999|Opitutae	414999|Opitutae	NU	Type II secretion system (T2SS), protein G	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
TH2_k127_301978_5	671143.DAMO_2488	3.791e-85	297.0	COG1459@1|root,COG1459@2|Bacteria,2NP2J@2323|unclassified Bacteria	2|Bacteria	U	Type II secretion system (T2SS), protein F	xpsF	GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098776	-	ko:K02455,ko:K02653	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSF
TH2_k127_301978_1	530564.Psta_3673	8.021e-160	529.0	COG2804@1|root,COG2804@2|Bacteria,2IYEE@203682|Planctomycetes	203682|Planctomycetes	NU	COG2804 Type II secretory pathway ATPase PulE Tfp pilus assembly pathway ATPase PilB	-	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
TH2_k127_301978_0	497964.CfE428DRAFT_3901	4.988e-202	654.0	COG0210@1|root,COG0210@2|Bacteria,46S8H@74201|Verrucomicrobia	74201|Verrucomicrobia	L	PFAM UvrD REP helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
TH2_k127_301978_16	1385935.N836_23380	7.783e-15	78.0	COG5548@1|root,COG5548@2|Bacteria,1G9NN@1117|Cyanobacteria,1HHD5@1150|Oscillatoriales	1117|Cyanobacteria	S	Transmembrane proteins 14C	-	-	-	-	-	-	-	-	-	-	-	-	Tmemb_14
TH2_k127_301978_8	452637.Oter_2745	5.385e-78	267.0	COG0106@1|root,COG0106@2|Bacteria,46SVR@74201|Verrucomicrobia,3K79Z@414999|Opitutae	414999|Opitutae	E	Histidine biosynthesis protein	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TH2_k127_301978_9	1121472.AQWN01000002_gene2274	5.35e-67	236.0	COG0118@1|root,COG0118@2|Bacteria,1TQT0@1239|Firmicutes,248SH@186801|Clostridia,260M0@186807|Peptococcaceae	186801|Clostridia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
TH2_k127_301978_14	1552758.NC00_15210	6.384e-18	89.0	295GT@1|root,2ZSUE@2|Bacteria,1PBNC@1224|Proteobacteria,1SUNQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_301978_3	497964.CfE428DRAFT_2172	1.44e-106	362.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,46SRG@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Competence-damaged protein	cinA	-	3.5.1.42	ko:K03742	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
TH2_k127_3029545_0	886293.Sinac_3249	0.0	1274.0	COG0209@1|root,COG0209@2|Bacteria,2IX3H@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
TH2_k127_3029545_1	349741.Amuc_2050	4.713e-19	88.0	COG1943@1|root,COG1943@2|Bacteria,46V2P@74201|Verrucomicrobia,2IVVU@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
TH2_k127_315640_3	1499967.BAYZ01000155_gene664	1.183e-68	258.0	COG0664@1|root,COG1752@1|root,COG4963@1|root,COG0664@2|Bacteria,COG1752@2|Bacteria,COG4963@2|Bacteria,2NR14@2323|unclassified Bacteria	2|Bacteria	U	Patatin-like phospholipase	-	-	-	ko:K02282,ko:K07001	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CbiA,HTH_Crp_2,Patatin,Response_reg,cNMP_binding
TH2_k127_315640_1	497964.CfE428DRAFT_5146	1.905e-152	500.0	COG1541@1|root,COG1541@2|Bacteria,46UTU@74201|Verrucomicrobia	74201|Verrucomicrobia	H	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
TH2_k127_315640_5	497964.CfE428DRAFT_3444	1.208e-56	201.0	COG0219@1|root,COG0219@2|Bacteria,46SYZ@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily	cspR	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
TH2_k127_315640_4	452637.Oter_3528	1.245e-59	219.0	COG0101@1|root,COG0101@2|Bacteria,46SSV@74201|Verrucomicrobia,3K80Q@414999|Opitutae	414999|Opitutae	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
TH2_k127_315640_8	452637.Oter_1403	3.448e-46	169.0	COG3123@1|root,COG3123@2|Bacteria,46VVG@74201|Verrucomicrobia,3K88M@414999|Opitutae	414999|Opitutae	S	Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions	ppnP	-	2.4.2.1,2.4.2.2	ko:K09913	ko00230,ko00240,map00230,map00240	-	R01561,R01570,R01863,R01876,R02147,R02296,R02297	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	DUF1255
TH2_k127_315640_7	1121468.AUBR01000016_gene2342	5.348e-47	177.0	COG1974@1|root,COG1974@2|Bacteria,1TQ3H@1239|Firmicutes,24AXJ@186801|Clostridia,42G7Y@68295|Thermoanaerobacterales	186801|Clostridia	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
TH2_k127_315640_13	1123288.SOV_4c07760	3.552e-21	96.0	COG2201@1|root,COG2201@2|Bacteria,1V98R@1239|Firmicutes,4H4XK@909932|Negativicutes	909932|Negativicutes	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TH2_k127_315640_6	1156937.MFUM_810035	1.032e-47	176.0	COG1528@1|root,COG1528@2|Bacteria,46WDU@74201|Verrucomicrobia,37GM9@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	P	Ferritin-like domain	ftn	-	1.16.3.1,1.16.3.2	ko:K02217,ko:K22336	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
TH2_k127_315640_11	269797.Mbar_A2604	4.136e-25	119.0	COG0457@1|root,arCOG03038@2157|Archaea,2XUNW@28890|Euryarchaeota,2NAN4@224756|Methanomicrobia	224756|Methanomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
TH2_k127_315640_0	1403819.BATR01000112_gene3730	4.117e-193	606.0	COG0057@1|root,COG0057@2|Bacteria,46S59@74201|Verrucomicrobia,2ITXT@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain	-	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
TH2_k127_315640_9	1216967.L100_12998	4.649e-30	122.0	COG2314@1|root,COG2314@2|Bacteria,4NSVZ@976|Bacteroidetes,1I3HF@117743|Flavobacteriia,34RPM@308865|Elizabethkingia	976|Bacteroidetes	S	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	TM2
TH2_k127_315640_12	590998.Celf_1805	4.696e-24	108.0	2E37T@1|root,32Y7G@2|Bacteria,2GQH5@201174|Actinobacteria,4F2VR@85016|Cellulomonadaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2752)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2752
TH2_k127_315640_20	985665.HPL003_27105	3.742e-05	53.0	2DQ8S@1|root,335BX@2|Bacteria,1UIQX@1239|Firmicutes,4ISQU@91061|Bacilli,2776W@186822|Paenibacillaceae	91061|Bacilli	S	Domain of unknown function (DUF4190)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190
TH2_k127_315640_19	452637.Oter_0732	3.319e-06	56.0	COG1714@1|root,COG1714@2|Bacteria	2|Bacteria	S	RDD family	-	-	-	ko:K18481	-	M00670	-	-	ko00000,ko00002,ko02000	3.A.1.27.4,3.A.1.27.5	-	-	DUF2510,FHA,RDD
TH2_k127_315640_10	102129.Lepto7375DRAFT_5884	9.661e-26	114.0	COG2314@1|root,COG2314@2|Bacteria,1G9J3@1117|Cyanobacteria,1HDPD@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	TM2
TH2_k127_315640_16	452637.Oter_0732	3.299e-11	71.0	COG1714@1|root,COG1714@2|Bacteria	2|Bacteria	S	RDD family	-	-	-	ko:K18481	-	M00670	-	-	ko00000,ko00002,ko02000	3.A.1.27.4,3.A.1.27.5	-	-	DUF2510,FHA,RDD
TH2_k127_315640_18	452637.Oter_0732	7.594e-07	58.0	COG1714@1|root,COG1714@2|Bacteria	2|Bacteria	S	RDD family	-	-	-	ko:K18481	-	M00670	-	-	ko00000,ko00002,ko02000	3.A.1.27.4,3.A.1.27.5	-	-	DUF2510,FHA,RDD
TH2_k127_315640_14	204669.Acid345_1886	2.464e-18	92.0	COG4640@1|root,COG4640@2|Bacteria	2|Bacteria	KT	response to antibiotic	-	-	-	-	-	-	-	-	-	-	-	-	CD225,DUF4339,zinc_ribbon_2
TH2_k127_315640_2	497964.CfE428DRAFT_0322	2.21e-102	346.0	COG0536@1|root,COG0536@2|Bacteria,46SBS@74201|Verrucomicrobia	74201|Verrucomicrobia	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
TH2_k127_315640_22	483215.BACFIN_07042	9.571e-05	57.0	2E8A6@1|root,332P2@2|Bacteria,4P1KY@976|Bacteroidetes,2FRQG@200643|Bacteroidia,4AN9F@815|Bacteroidaceae	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_315640_21	1210884.HG799464_gene10785	5.526e-05	58.0	COG1520@1|root,COG1520@2|Bacteria,2IYEA@203682|Planctomycetes	203682|Planctomycetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
TH2_k127_315640_15	502025.Hoch_2322	3.315e-14	80.0	COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,42U5W@68525|delta/epsilon subdivisions,2WQUQ@28221|Deltaproteobacteria,2YX8E@29|Myxococcales	28221|Deltaproteobacteria	L	Transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,Nterm_IS4
TH2_k127_315640_17	1403819.BATR01000004_gene120	2.662e-08	59.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1,DDE_Tnp_1_4
TH2_k127_3197602_0	667014.Thein_2162	1.508e-66	235.0	COG1912@1|root,COG1912@2|Bacteria,2GHAQ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
TH2_k127_3197602_1	396014.BF93_18460	7.356e-28	121.0	COG0546@1|root,COG0546@2|Bacteria,2I9FC@201174|Actinobacteria,4FD9K@85020|Dermabacteraceae	201174|Actinobacteria	S	haloacid dehalogenase-like hydrolase	-	-	3.1.3.18,3.6.1.1	ko:K01091,ko:K06019	ko00190,ko00630,ko01100,ko01110,ko01130,map00190,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
TH2_k127_3197602_2	278957.ABEA03000200_gene4365	2.726e-11	66.0	COG0544@1|root,COG0544@2|Bacteria,46SJZ@74201|Verrucomicrobia,3K7I6@414999|Opitutae	414999|Opitutae	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	Trigger_C,Trigger_N
TH2_k127_3214632_1	696369.KI912183_gene79	9.119e-39	163.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,249VR@186801|Clostridia,26014@186807|Peptococcaceae	186801|Clostridia	S	DNA internalization-related competence protein ComEC Rec2	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
TH2_k127_3214632_0	309801.trd_0398	4.533e-66	238.0	COG0351@1|root,COG0351@2|Bacteria,2G5R7@200795|Chloroflexi,27XQP@189775|Thermomicrobia	189775|Thermomicrobia	H	Phosphomethylpyrimidine kinase	-	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
TH2_k127_3271579_6	595460.RRSWK_06184	7.395e-48	186.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	NHL
TH2_k127_3271579_2	1168034.FH5T_01575	1.086e-131	436.0	COG1520@1|root,COG1520@2|Bacteria,4P15Y@976|Bacteroidetes,2FWBU@200643|Bacteroidia	976|Bacteroidetes	S	PQQ-like domain	-	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2
TH2_k127_3271579_7	595460.RRSWK_06184	3.681e-39	160.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	NHL
TH2_k127_3271579_5	1168034.FH5T_01560	2.172e-75	260.0	2DVMZ@1|root,33WFQ@2|Bacteria,4P3VR@976|Bacteroidetes,2FXVM@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	-
TH2_k127_3271579_3	1168034.FH5T_01555	1.273e-114	387.0	COG0348@1|root,COG0348@2|Bacteria,4NPVD@976|Bacteroidetes,2FTEY@200643|Bacteroidia	976|Bacteroidetes	C	FMN-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_5
TH2_k127_3271579_4	1168034.FH5T_01550	1.423e-106	367.0	COG1520@1|root,COG1520@2|Bacteria,4P1VG@976|Bacteroidetes,2FW8D@200643|Bacteroidia	976|Bacteroidetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
TH2_k127_3271579_0	1168034.FH5T_01545	1.636e-279	891.0	COG1894@1|root,COG1894@2|Bacteria,4NFB5@976|Bacteroidetes,2FN7A@200643|Bacteroidia	976|Bacteroidetes	C	COG1894 NADH ubiquinone oxidoreductase, NADH-binding (51 kD) subunit	nuoF	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
TH2_k127_3271579_1	1168034.FH5T_01535	8.484e-146	479.0	COG0493@1|root,COG0493@2|Bacteria,4P2CU@976|Bacteroidetes,2FXPN@200643|Bacteroidia	976|Bacteroidetes	E	2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4,Fer4_20
TH2_k127_329705_2	497964.CfE428DRAFT_1082	2.976e-149	478.0	COG1222@1|root,COG1222@2|Bacteria,46UBC@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Proteasomal ATPase OB/ID domain	-	-	-	ko:K13527	ko03050,map03050	M00342	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA,Prot_ATP_ID_OB
TH2_k127_329705_0	497964.CfE428DRAFT_4751	2.203e-194	620.0	COG4122@1|root,COG4122@2|Bacteria,46TEU@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Pup-ligase protein	-	-	3.5.1.119	ko:K20814	-	-	-	-	ko00000,ko01000,ko03051	-	-	-	Pup_ligase
TH2_k127_329705_7	497964.CfE428DRAFT_3468	3.914e-16	79.0	2ERDX@1|root,33IZH@2|Bacteria,46WUJ@74201|Verrucomicrobia	74201|Verrucomicrobia	S	May function as a protein modifier covalently attached to lysine residues of substrate proteins. This may serve to target the modified proteins for degradation by proteasomes	ubact	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_329705_3	497964.CfE428DRAFT_3467	2.587e-87	296.0	COG0638@1|root,COG0638@2|Bacteria,46UC7@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Proteasome subunit	-	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
TH2_k127_329705_4	497964.CfE428DRAFT_3466	6.862e-61	219.0	COG0638@1|root,COG0638@2|Bacteria,46VYB@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Proteasome subunit	-	-	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
TH2_k127_329705_1	497964.CfE428DRAFT_3471	9.046e-179	571.0	COG4122@1|root,COG4122@2|Bacteria,46TZ5@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Pup-ligase protein	-	-	6.3.1.19	ko:K13571	-	M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051	-	-	-	Pup_ligase
TH2_k127_329705_5	1201288.M900_2029	3.901e-43	163.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,42MCS@68525|delta/epsilon subdivisions,2MUR5@213481|Bdellovibrionales,2WQGI@28221|Deltaproteobacteria	213481|Bdellovibrionales	O	Peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
TH2_k127_329705_6	317619.ANKN01000161_gene313	6.866e-24	106.0	COG0745@1|root,COG0745@2|Bacteria,1G1EZ@1117|Cyanobacteria,1MKDA@1212|Prochloraceae	1117|Cyanobacteria	T	Alternative locus ID	rpaA	-	-	ko:K10697	ko02020,map02020	M00467	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TH2_k127_3354510_1	177437.HRM2_44710	1.113e-126	421.0	COG1321@1|root,COG1321@2|Bacteria,1N8WG@1224|Proteobacteria	1224|Proteobacteria	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3354510_0	1403819.BATR01000114_gene3995	5.787e-141	462.0	COG1236@1|root,COG1236@2|Bacteria,46UFS@74201|Verrucomicrobia,2ITNR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
TH2_k127_3354510_2	1121373.KB903663_gene1230	4.878e-05	52.0	COG3210@1|root,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	4.2.2.20,4.2.2.21	ko:K08961	-	-	-	-	ko00000,ko01000	-	-	-	CHU_C,Calx-beta,Lyase_8,Lyase_catalyt,PA14,SdrD_B
TH2_k127_3364630_6	1144275.COCOR_02776	2.913e-19	102.0	COG4875@1|root,COG4875@2|Bacteria	2|Bacteria	IQ	SnoaL-like domain	-	-	5.3.3.1	ko:K01822	ko00140,ko00984,ko01100,ko01120,map00140,map00984,map01100,map01120	M00107,M00110	R01837,R02216,R02499,R02840,R03327,R04163,R04678,R04849,R09955	RC00146,RC00762	ko00000,ko00001,ko00002,ko01000	-	-	-	CaMKII_AD,DUF4440,SnoaL_2,SnoaL_3
TH2_k127_3364630_0	1396141.BATP01000022_gene237	6.703e-153	491.0	2BWJ3@1|root,2Z7IQ@2|Bacteria	2|Bacteria	S	PFAM Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
TH2_k127_3364630_1	1396141.BATP01000022_gene238	2.354e-144	475.0	COG2124@1|root,COG2124@2|Bacteria,46XEJ@74201|Verrucomicrobia,2IVPB@203494|Verrucomicrobiae	203494|Verrucomicrobiae	Q	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TH2_k127_3364630_2	1173028.ANKO01000112_gene4786	9.502e-136	441.0	COG5379@1|root,COG5379@2|Bacteria,1GC1E@1117|Cyanobacteria,1HEN7@1150|Oscillatoriales	1117|Cyanobacteria	I	Protein of unknown function (DUF3419)	-	-	-	ko:K13622	ko00564,map00564	-	R09072	RC00021,RC01091	ko00000,ko00001	-	-	-	DUF3419
TH2_k127_3364630_5	861299.J421_1814	2.264e-87	305.0	COG0170@1|root,COG0170@2|Bacteria	2|Bacteria	I	dolichyl monophosphate biosynthetic process	-	-	2.7.1.182,2.7.7.41	ko:K00981,ko:K18678	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799,R10659	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1,DUF92
TH2_k127_3364630_4	1173028.ANKO01000112_gene4785	2.433e-92	331.0	COG3153@1|root,COG3153@2|Bacteria,1GQ2E@1117|Cyanobacteria,1HHZD@1150|Oscillatoriales	1117|Cyanobacteria	S	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3364630_3	1173028.ANKO01000111_gene4995	7.793e-131	445.0	COG0318@1|root,COG0318@2|Bacteria,1G4CE@1117|Cyanobacteria,1H8QS@1150|Oscillatoriales	1117|Cyanobacteria	IQ	Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	6.1.3.1	ko:K22319	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding,AMP-binding_C,PP-binding
TH2_k127_3370754_3	497964.CfE428DRAFT_5668	2.138e-67	249.0	COG0457@1|root,COG0457@2|Bacteria,46V4J@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_8
TH2_k127_3370754_1	240016.ABIZ01000001_gene5891	5.439e-119	401.0	COG0040@1|root,COG0040@2|Bacteria,46SHK@74201|Verrucomicrobia,2ITH9@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	ATP phosphoribosyltransferase	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
TH2_k127_3370754_4	1121422.AUMW01000001_gene2351	1.353e-66	233.0	COG0299@1|root,COG0299@2|Bacteria,1V3RJ@1239|Firmicutes,249JC@186801|Clostridia,261MS@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS04225	Formyl_trans_N
TH2_k127_3370754_13	344747.PM8797T_28764	0.0009721	46.0	2DNKX@1|root,32Y1B@2|Bacteria,2J0P2@203682|Planctomycetes	203682|Planctomycetes	S	Glycine zipper	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp
TH2_k127_3370754_7	1396418.BATQ01000166_gene1881	1.435e-46	175.0	COG0299@1|root,COG0615@1|root,COG0299@2|Bacteria,COG0615@2|Bacteria,46SUW@74201|Verrucomicrobia,2IWN8@203494|Verrucomicrobiae	203494|Verrucomicrobiae	FIM	Cytidylyltransferase-like	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like,Formyl_trans_N
TH2_k127_3370754_0	404589.Anae109_0714	8.53e-168	544.0	COG1215@1|root,COG1215@2|Bacteria,1MX08@1224|Proteobacteria,42MS6@68525|delta/epsilon subdivisions,2WIYE@28221|Deltaproteobacteria,2YUMA@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
TH2_k127_3370754_6	1125863.JAFN01000001_gene83	6.959e-48	179.0	COG2020@1|root,COG2020@2|Bacteria,1RBUU@1224|Proteobacteria,42UT0@68525|delta/epsilon subdivisions,2WQKM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
TH2_k127_3370754_11	743721.Psesu_1896	8.35e-08	63.0	COG0697@1|root,COG0697@2|Bacteria,1MZQM@1224|Proteobacteria,1RS0P@1236|Gammaproteobacteria,1X4DJ@135614|Xanthomonadales	135614|Xanthomonadales	EG	Drug metabolite transporter	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TH2_k127_3370754_2	794903.OPIT5_12845	1.12e-102	340.0	COG4813@1|root,COG4813@2|Bacteria,46TVG@74201|Verrucomicrobia,3K7P1@414999|Opitutae	414999|Opitutae	G	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	ThuA
TH2_k127_3370754_5	1156937.MFUM_270014	3.752e-56	209.0	COG2006@1|root,COG2006@2|Bacteria,46T4A@74201|Verrucomicrobia,37GDX@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
TH2_k127_3370754_12	794903.OPIT5_14830	0.0001659	51.0	COG4968@1|root,COG4968@2|Bacteria	794903.OPIT5_14830|-	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3370754_8	1396141.BATP01000032_gene4325	3.245e-24	115.0	COG0265@1|root,COG0265@2|Bacteria,46W40@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3370754_9	991905.SL003B_1383	4.862e-15	87.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,4BPCV@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the peptidase S1C family	degP	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
TH2_k127_3370754_10	1028800.RG540_CH17810	1.505e-13	83.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,4BA3T@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Belongs to the peptidase S1C family	degPch1	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
TH2_k127_3378641_11	509191.AEDB02000074_gene1742	2.797e-07	63.0	COG0457@1|root,COG0457@2|Bacteria,1V6SR@1239|Firmicutes,24KI3@186801|Clostridia,3WMMF@541000|Ruminococcaceae	186801|Clostridia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_10,TPR_12,TPR_16,TPR_2,TPR_8
TH2_k127_3378641_3	478741.JAFS01000002_gene872	2.776e-87	306.0	COG1519@1|root,COG1519@2|Bacteria,46SK9@74201|Verrucomicrobia,37G30@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)	kdtA	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_1,Glycos_transf_N
TH2_k127_3378641_7	880073.Calab_0900	8.463e-39	152.0	COG2078@1|root,COG2078@2|Bacteria,2NPQ0@2323|unclassified Bacteria	2|Bacteria	S	AMMECR1	-	-	-	ko:K06990,ko:K09141	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,Memo
TH2_k127_3378641_5	671143.DAMO_2823	3.521e-68	239.0	COG1801@1|root,COG1801@2|Bacteria	2|Bacteria	L	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
TH2_k127_3378641_0	682795.AciX8_1526	8.575e-211	674.0	COG1874@1|root,COG1874@2|Bacteria,3Y2WD@57723|Acidobacteria,2JIC9@204432|Acidobacteriia	204432|Acidobacteriia	G	Beta-galactosidase trimerisation domain	-	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_42,Glyco_hydro_42C,Glyco_hydro_42M
TH2_k127_3378641_1	251229.Chro_3531	3.537e-96	328.0	COG4398@1|root,COG4398@2|Bacteria,1G0TB@1117|Cyanobacteria,3VKSH@52604|Pleurocapsales	1117|Cyanobacteria	S	PFAM FIST C domain	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C
TH2_k127_3378641_2	1304880.JAGB01000001_gene276	4.627e-95	326.0	COG4198@1|root,COG4198@2|Bacteria,1TQSW@1239|Firmicutes,249E4@186801|Clostridia	186801|Clostridia	S	Conserved protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
TH2_k127_3378641_4	1341181.FLJC2902T_15110	1.609e-78	286.0	COG3386@1|root,COG3386@2|Bacteria,4PKPT@976|Bacteroidetes,1IKDI@117743|Flavobacteriia,2P0DY@237|Flavobacterium	976|Bacteroidetes	G	Domain of unknown function (DUF5122) beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122
TH2_k127_3378641_12	329726.AM1_1017	9.03e-06	59.0	COG3391@1|root,COG3827@1|root,COG3391@2|Bacteria,COG3827@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	3.6.4.13	ko:K03496,ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036,ko04812	-	-	-	ADPrib_exo_Tox,TonB_2
TH2_k127_3378641_6	1147.D082_25660	3.108e-66	259.0	COG2931@1|root,COG3204@1|root,COG3210@1|root,COG5184@1|root,COG2931@2|Bacteria,COG3204@2|Bacteria,COG3210@2|Bacteria,COG5184@2|Bacteria,1G5KY@1117|Cyanobacteria,1H6DE@1142|Synechocystis	1117|Cyanobacteria	QU	Cadherin repeats.	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Calx-beta,HemolysinCabind,VCBS
TH2_k127_3378641_10	1242864.D187_007221	8.195e-08	67.0	COG0515@1|root,COG0515@2|Bacteria	1242864.D187_007221|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3378641_8	886293.Sinac_7495	8.098e-24	120.0	COG1361@1|root,COG4655@1|root,COG1361@2|Bacteria,COG4655@2|Bacteria,2IYS8@203682|Planctomycetes	203682|Planctomycetes	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
TH2_k127_3378641_15	180281.CPCC7001_2087	0.0001561	44.0	COG0167@1|root,COG0167@2|Bacteria,1G2B6@1117|Cyanobacteria,22RRP@167375|Cyanobium	1117|Cyanobacteria	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
TH2_k127_3384581_0	1403819.BATR01000195_gene6595	1.863e-200	639.0	COG5421@1|root,COG5421@2|Bacteria,46U8B@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
TH2_k127_3384581_1	1291050.JAGE01000001_gene868	1.212e-126	432.0	COG1858@1|root,COG2730@1|root,COG3391@1|root,COG1858@2|Bacteria,COG2730@2|Bacteria,COG3391@2|Bacteria,1TSS4@1239|Firmicutes,24F1E@186801|Clostridia,3WHGQ@541000|Ruminococcaceae	186801|Clostridia	GP	Ricin-type beta-trefoil	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Dockerin_1,RicinB_lectin_2
TH2_k127_3387684_0	240016.ABIZ01000001_gene3775	5.477e-72	254.0	COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,46V45@74201|Verrucomicrobia,2IVR0@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2,MerR_1
TH2_k127_3392533_0	118163.Ple7327_1940	2.015e-08	68.0	28N1B@1|root,2ZB7I@2|Bacteria,1G011@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3401042_0	926569.ANT_00770	1.349e-160	553.0	COG2373@1|root,COG2373@2|Bacteria,2G8BN@200795|Chloroflexi	200795|Chloroflexi	S	A-macroglobulin receptor	-	-	-	-	-	-	-	-	-	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,A2M_recep,Thiol-ester_cl
TH2_k127_3401042_1	404589.Anae109_0250	1.299e-29	126.0	COG1595@1|root,COG1595@2|Bacteria,1N38X@1224|Proteobacteria,42U8K@68525|delta/epsilon subdivisions,2WPZ9@28221|Deltaproteobacteria,2YV95@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TH2_k127_3409760_18	278957.ABEA03000106_gene1851	5.657e-84	283.0	COG4096@1|root,COG4096@2|Bacteria,46VP9@74201|Verrucomicrobia,3K9SC@414999|Opitutae	414999|Opitutae	L	EcoEI R protein C-terminal	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	EcoEI_R_C,Helicase_C,ResIII
TH2_k127_3409760_39	195250.CM001776_gene698	3.043e-17	85.0	COG3547@1|root,COG3547@2|Bacteria,1G5MH@1117|Cyanobacteria	1117|Cyanobacteria	L	Transposase is116 is110 is902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
TH2_k127_3409760_16	1403819.BATR01000181_gene6220	5.151e-87	295.0	COG0217@1|root,COG0217@2|Bacteria,46SMV@74201|Verrucomicrobia,2IWMS@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
TH2_k127_3409760_12	1123508.JH636439_gene798	2.337e-100	337.0	COG2107@1|root,COG2107@2|Bacteria,2IXIY@203682|Planctomycetes	203682|Planctomycetes	S	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnD	-	-	ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
TH2_k127_3409760_52	1121448.DGI_2787	3.374e-09	64.0	COG4747@1|root,COG4747@2|Bacteria,1RDCG@1224|Proteobacteria,42RTD@68525|delta/epsilon subdivisions,2WNC2@28221|Deltaproteobacteria,2MBI7@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM Amino acid-binding ACT	-	-	-	-	-	-	-	-	-	-	-	-	ACT
TH2_k127_3409760_7	398512.JQKC01000014_gene1553	1.693e-136	445.0	COG0119@1|root,COG0119@2|Bacteria,1TS0A@1239|Firmicutes,247MU@186801|Clostridia,3WHBT@541000|Ruminococcaceae	186801|Clostridia	E	HMGL-like	-	-	4.1.3.39	ko:K01666	ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220	M00545,M00569	R00750	RC00307,RC00371	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
TH2_k127_3409760_26	243365.CV_1103	3.944e-59	209.0	COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,2VMQQ@28216|Betaproteobacteria,2KQV2@206351|Neisseriales	206351|Neisseriales	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
TH2_k127_3409760_28	1453503.AU05_13500	2.353e-45	179.0	COG4339@1|root,COG4339@2|Bacteria,1MZ9X@1224|Proteobacteria,1S59I@1236|Gammaproteobacteria,1YGN1@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3409760_1	497964.CfE428DRAFT_3032	2.818e-202	640.0	COG1109@1|root,COG1109@2|Bacteria,46SJ2@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TH2_k127_3409760_44	1480694.DC28_05535	7.168e-16	89.0	COG4856@1|root,COG4856@2|Bacteria,2J5XW@203691|Spirochaetes	203691|Spirochaetes	S	YbbR-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
TH2_k127_3409760_25	1396418.BATQ01000056_gene232	1.617e-60	222.0	COG1624@1|root,COG1624@2|Bacteria,46SSQ@74201|Verrucomicrobia,2IU56@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	DisA bacterial checkpoint controller nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	DisA_N
TH2_k127_3409760_17	195250.CM001776_gene3990	1.257e-84	292.0	COG0294@1|root,COG0294@2|Bacteria,1G050@1117|Cyanobacteria,1GZAI@1129|Synechococcus	1117|Cyanobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.15	ko:K00796,ko:K18824	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Pterin_bind
TH2_k127_3409760_40	350054.Mflv_3575	3.534e-17	87.0	COG3707@1|root,COG3707@2|Bacteria,2GK7T@201174|Actinobacteria,235QN@1762|Mycobacteriaceae	201174|Actinobacteria	T	response regulator	pdtaR	GO:0000160,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0023052,GO:0030312,GO:0035556,GO:0040007,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071944	-	ko:K22010	-	M00839	-	-	ko00000,ko00002,ko02022	-	-	-	ANTAR,Response_reg
TH2_k127_3409760_2	497964.CfE428DRAFT_3627	2.682e-200	631.0	COG0148@1|root,COG0148@2|Bacteria,46S7N@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
TH2_k127_3409760_53	481448.Minf_0311	1.979e-06	56.0	COG2919@1|root,COG2919@2|Bacteria,46ZEA@74201|Verrucomicrobia,37GXB@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	D	Septum formation initiator	-	-	-	-	-	-	-	-	-	-	-	-	DivIC
TH2_k127_3409760_10	452637.Oter_3094	1.075e-115	394.0	COG2202@1|root,COG2208@1|root,COG2202@2|Bacteria,COG2208@2|Bacteria,46U96@74201|Verrucomicrobia	74201|Verrucomicrobia	KT	PFAM Stage II sporulation E family protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	PAS_3,PAS_4,SpoIIE
TH2_k127_3409760_43	497964.CfE428DRAFT_6294	1.63e-16	90.0	2E0WZ@1|root,32WDX@2|Bacteria,46WD0@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3409760_0	497964.CfE428DRAFT_0818	1.127e-295	929.0	COG0046@1|root,COG0046@2|Bacteria,46S8Y@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
TH2_k127_3409760_5	1173022.Cri9333_1431	1.114e-156	510.0	COG1064@1|root,COG1064@2|Bacteria,1G0B9@1117|Cyanobacteria,1H851@1150|Oscillatoriales	1117|Cyanobacteria	C	COG1064 Zn-dependent alcohol	-	-	-	ko:K13979	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
TH2_k127_3409760_56	1267535.KB906767_gene2307	0.0008778	50.0	COG2982@1|root,COG2982@2|Bacteria	2|Bacteria	M	Protein involved in outer membrane biogenesis	asmA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0032386,GO:0032879,GO:0032880,GO:0033157,GO:0044464,GO:0050789,GO:0051049,GO:0051223,GO:0060341,GO:0065007,GO:0070201,GO:0071944,GO:0090087,GO:0090313,GO:1903533,GO:1903827,GO:1905475	-	ko:K07289,ko:K07290	-	-	-	-	ko00000	9.B.121	-	-	AsmA,AsmA_2
TH2_k127_3409760_29	1045855.DSC_11945	2.091e-44	164.0	COG0314@1|root,COG0314@2|Bacteria,1RGUX@1224|Proteobacteria,1S5YH@1236|Gammaproteobacteria,1X77N@135614|Xanthomonadales	135614|Xanthomonadales	H	MoaE protein	-	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
TH2_k127_3409760_45	153496.JNAB01000011_gene163	1.783e-15	81.0	COG1977@1|root,COG1977@2|Bacteria,1NAHE@1224|Proteobacteria,2VFYI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
TH2_k127_3409760_27	1234364.AMSF01000015_gene3111	4.192e-52	190.0	COG0746@1|root,COG0746@2|Bacteria,1PJ8G@1224|Proteobacteria,1T6R6@1236|Gammaproteobacteria,1X7YT@135614|Xanthomonadales	135614|Xanthomonadales	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	-	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
TH2_k127_3409760_30	1123276.KB893257_gene2810	3.088e-38	150.0	COG0315@1|root,COG0315@2|Bacteria,4NHA0@976|Bacteroidetes,47PU9@768503|Cytophagia	976|Bacteroidetes	H	MoaC family	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
TH2_k127_3409760_14	1123227.KB899336_gene392	6.843e-90	309.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2TQRI@28211|Alphaproteobacteria,2JPHJ@204441|Rhodospirillales	204441|Rhodospirillales	H	MoeA N-terminal region (domain I and II)	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
TH2_k127_3409760_9	518766.Rmar_1285	1.85e-120	402.0	COG0714@1|root,COG0714@2|Bacteria,4NDVZ@976|Bacteroidetes,1FJ1G@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	ATPase family associated with various cellular activities (AAA)	moxR	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TH2_k127_3409760_50	452637.Oter_0811	5.772e-10	64.0	28SYW@1|root,2ZF89@2|Bacteria,46WJW@74201|Verrucomicrobia,3K896@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3409760_54	1410620.SHLA_8c001280	0.0006339	46.0	2DI5N@1|root,3023P@2|Bacteria,1Q75D@1224|Proteobacteria,2VD9R@28211|Alphaproteobacteria,4BHDM@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2934)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2934
TH2_k127_3409760_49	118166.JH976537_gene1281	5.276e-11	76.0	COG3307@1|root,COG3307@2|Bacteria,1G15X@1117|Cyanobacteria,1H7X0@1150|Oscillatoriales	1117|Cyanobacteria	M	O-antigen ligase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
TH2_k127_3409760_35	497964.CfE428DRAFT_3652	3.861e-30	128.0	COG1366@1|root,COG1366@2|Bacteria,46T4Z@74201|Verrucomicrobia	74201|Verrucomicrobia	T	PFAM Sulfate transporter antisigma-factor antagonist STAS	rsbS	-	-	-	-	-	-	-	-	-	-	-	STAS
TH2_k127_3409760_46	596324.TREVI0001_1707	2.993e-15	81.0	COG1366@1|root,COG1366@2|Bacteria,2J6J8@203691|Spirochaetes	203691|Spirochaetes	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	-	-	-	-	-	-	-	-	-	STAS
TH2_k127_3409760_38	765420.OSCT_2692	8.076e-19	96.0	COG1366@1|root,COG2172@1|root,COG1366@2|Bacteria,COG2172@2|Bacteria,2G93H@200795|Chloroflexi,375J3@32061|Chloroflexia	32061|Chloroflexia	T	PFAM Sulfate transporter antisigma-factor antagonist STAS	-	-	2.7.11.1	ko:K04749,ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2,STAS
TH2_k127_3409760_34	1232410.KI421424_gene1721	3.923e-32	136.0	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,42TM2@68525|delta/epsilon subdivisions,2WQ0U@28221|Deltaproteobacteria,43US5@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	GrpE	grpE	GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
TH2_k127_3409760_6	497964.CfE428DRAFT_3655	6.429e-148	477.0	COG0484@1|root,COG0484@2|Bacteria,46TKC@74201|Verrucomicrobia	74201|Verrucomicrobia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
TH2_k127_3409760_8	497964.CfE428DRAFT_4694	4.4e-125	414.0	COG0612@1|root,COG0612@2|Bacteria	2|Bacteria	L	Peptidase, M16	pepR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TH2_k127_3409760_21	56780.SYN_01766	8.375e-79	269.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,42P56@68525|delta/epsilon subdivisions,2WK5J@28221|Deltaproteobacteria,2MQ5V@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
TH2_k127_3409760_51	1408422.JHYF01000001_gene2963	6.31e-10	64.0	2DH0V@1|root,2ZY0A@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3409760_31	1128421.JAGA01000003_gene3692	9.521e-37	159.0	COG0793@1|root,COG0793@2|Bacteria,2NNVZ@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,PG_binding_1,Peptidase_S41
TH2_k127_3409760_3	382464.ABSI01000012_gene1970	3.542e-179	579.0	COG1530@1|root,COG1530@2|Bacteria,46S5S@74201|Verrucomicrobia,2ITMW@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Ribonuclease E/G family	-	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G
TH2_k127_3409760_15	481448.Minf_1719	2.539e-88	305.0	COG0772@1|root,COG0772@2|Bacteria,46SQT@74201|Verrucomicrobia,37G6K@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	D	Cell cycle protein	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
TH2_k127_3409760_11	443144.GM21_1757	2.041e-112	386.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,42M1S@68525|delta/epsilon subdivisions,2WJ02@28221|Deltaproteobacteria,43U7Y@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	PFAM penicillin-binding protein transpeptidase	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0928	PBP_dimer,Transpeptidase
TH2_k127_3409760_32	671143.DAMO_3132	2.178e-36	147.0	COG1792@1|root,COG1792@2|Bacteria,2NPNX@2323|unclassified Bacteria	2|Bacteria	M	Cell shape-determining protein MreC	mreC	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007163,GO:0008150,GO:0008360,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0030428,GO:0031224,GO:0031226,GO:0042546,GO:0043621,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071554,GO:0071840,GO:0071944,GO:0071963	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
TH2_k127_3409760_4	240016.ABIZ01000001_gene3227	3.523e-164	523.0	COG1077@1|root,COG1077@2|Bacteria,46SAA@74201|Verrucomicrobia,2ITYI@203494|Verrucomicrobiae	203494|Verrucomicrobiae	D	Actin	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
TH2_k127_3409760_55	289376.THEYE_A1803	0.0008582	48.0	28U9C@1|root,2ZGEW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3409760_23	156889.Mmc1_0977	1.029e-70	250.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2TQMD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	GM	3-beta hydroxysteroid dehydrogenase	MA20_24380	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	3Beta_HSD,Epimerase,NAD_binding_10,RmlD_sub_bind
TH2_k127_3409760_13	497964.CfE428DRAFT_2574	7.682e-97	331.0	COG1820@1|root,COG1820@2|Bacteria	2|Bacteria	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	nagA	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
TH2_k127_3409760_24	316067.Geob_0957	1.26e-66	252.0	COG3568@1|root,COG3568@2|Bacteria,1R977@1224|Proteobacteria,43AKV@68525|delta/epsilon subdivisions,2X60Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TH2_k127_3409760_47	883126.HMPREF9710_01777	9.361e-13	75.0	COG2823@1|root,COG2823@2|Bacteria	2|Bacteria	S	hyperosmotic response	-	-	-	ko:K04065	-	-	-	-	ko00000	-	-	-	BON
TH2_k127_3409760_48	134676.ACPL_160	3.281e-11	69.0	COG1716@1|root,COG1716@2|Bacteria,2GNU2@201174|Actinobacteria,4DB9K@85008|Micromonosporales	201174|Actinobacteria	T	FHA domain	fhaA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363	-	-	-	-	-	-	-	-	-	-	DUF3662,FHA,Yop-YscD_cpl
TH2_k127_3409760_33	344747.PM8797T_05965	4.354e-36	145.0	COG4293@1|root,COG4293@2|Bacteria,2J0GT@203682|Planctomycetes	203682|Planctomycetes	S	Domain of unknown function (DUF1802)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1802
TH2_k127_3409760_20	56780.SYN_01023	1.982e-80	287.0	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,42ME9@68525|delta/epsilon subdivisions,2WKF0@28221|Deltaproteobacteria,2MQH2@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	tRNA (Uracil-5-)-methyltransferase	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
TH2_k127_3409760_19	1123288.SOV_5c03890	6e-84	287.0	COG1099@1|root,COG1099@2|Bacteria,1UZM4@1239|Firmicutes	1239|Firmicutes	S	PFAM TatD-related deoxyribonuclease	-	-	-	ko:K07051	-	-	-	-	ko00000	-	-	-	TatD_DNase
TH2_k127_3409760_37	1123070.KB899263_gene1750	2.243e-24	106.0	COG3536@1|root,COG3536@2|Bacteria,46VNP@74201|Verrucomicrobia,2IUSM@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Protein of unknown function (DUF971)	-	-	-	-	-	-	-	-	-	-	-	-	DUF971
TH2_k127_3409760_22	478741.JAFS01000001_gene1393	2.972e-75	263.0	COG0177@1|root,COG0177@2|Bacteria,46T2G@74201|Verrucomicrobia,37GJA@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
TH2_k127_3409760_42	357808.RoseRS_0231	4.779e-17	86.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,2G7Y4@200795|Chloroflexi,374VX@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_8,Response_reg
TH2_k127_3409760_36	889378.Spiaf_2034	4.027e-29	128.0	COG0767@1|root,COG0767@2|Bacteria,2J7BX@203691|Spirochaetes	203691|Spirochaetes	Q	ABC-type transport system involved in resistance to organic solvents permease component	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
TH2_k127_3409760_41	633149.Bresu_1454	4.678e-17	91.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2TR2I@28211|Alphaproteobacteria,2KF7N@204458|Caulobacterales	204458|Caulobacterales	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
TH2_k127_3437996_0	1196322.A370_03281	1.362e-08	64.0	COG0778@1|root,COG0778@2|Bacteria,1UB8S@1239|Firmicutes,249SD@186801|Clostridia,36FUT@31979|Clostridiaceae	186801|Clostridia	C	Nitroreductase family	-	-	1.5.1.39	ko:K19286	ko00740,ko01100,map00740,map01100	-	R05705,R05706	RC00126	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
TH2_k127_3437996_1	545695.TREAZ_3394	7.989e-07	58.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
TH2_k127_3440470_8	247633.GP2143_00482	1.054e-07	55.0	2DRA2@1|root,33AVQ@2|Bacteria,1NKZA@1224|Proteobacteria,1SH2Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3440470_9	1500890.JQNL01000001_gene2188	2.678e-05	49.0	COG1714@1|root,COG1714@2|Bacteria,1N1XF@1224|Proteobacteria,1SDY3@1236|Gammaproteobacteria,1X5Z4@135614|Xanthomonadales	135614|Xanthomonadales	NU	membrane protein domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4339,RDD
TH2_k127_3440470_2	880073.Calab_2039	2.259e-50	198.0	COG0389@1|root,COG0389@2|Bacteria,2NP5S@2323|unclassified Bacteria	2|Bacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	GO:0003674,GO:0003824,GO:0003887,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
TH2_k127_3440470_6	330214.NIDE4271	3.369e-22	101.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	nla6	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH2_k127_3440470_5	1117958.PE143B_0116175	4.717e-23	110.0	COG0810@1|root,COG0810@2|Bacteria,1MZPX@1224|Proteobacteria,1S7VF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	tonB2	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
TH2_k127_3440470_3	518766.Rmar_0243	7.772e-49	182.0	COG0491@1|root,COG0491@2|Bacteria,4NE2Y@976|Bacteroidetes,1FJ7Q@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TH2_k127_3440470_4	880072.Desac_1765	4.215e-27	117.0	COG1247@1|root,COG1247@2|Bacteria,1R6UW@1224|Proteobacteria	1224|Proteobacteria	M	Acetyltransferase (GNAT) domain	MA20_16670	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TH2_k127_3440470_1	583355.Caka_2172	1.69e-60	218.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_7C,Glycos_transf_2
TH2_k127_3440470_0	1121448.DGI_1524	2.758e-62	241.0	COG3291@1|root,COG3291@2|Bacteria,1PHGX@1224|Proteobacteria,437VV@68525|delta/epsilon subdivisions,2X1BB@28221|Deltaproteobacteria,2MEPR@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Metallo-peptidase family M12B Reprolysin-like	-	-	-	-	-	-	-	-	-	-	-	-	Reprolysin_5
TH2_k127_3440470_7	471854.Dfer_0264	1.593e-21	111.0	COG4733@1|root,COG4733@2|Bacteria,4NK2V@976|Bacteroidetes,47P6C@768503|Cytophagia	976|Bacteroidetes	G	PFAM Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	fn3
TH2_k127_3501633_3	794903.OPIT5_00620	1.93e-107	368.0	COG1840@1|root,COG1840@2|Bacteria,46SF5@74201|Verrucomicrobia,3K7IW@414999|Opitutae	414999|Opitutae	P	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_6
TH2_k127_3501633_2	278957.ABEA03000180_gene2021	3.371e-190	615.0	COG1178@1|root,COG1178@2|Bacteria,46SFB@74201|Verrucomicrobia,3K7UZ@414999|Opitutae	414999|Opitutae	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
TH2_k127_3501633_1	160799.PBOR_13505	2.997e-194	618.0	COG3408@1|root,COG3408@2|Bacteria,1V435@1239|Firmicutes	1239|Firmicutes	G	Glycosyl hydrolase family 63 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Trehalase
TH2_k127_3501633_6	1449048.JQKU01000006_gene5258	3.833e-06	55.0	COG4402@1|root,COG4402@2|Bacteria,2I90K@201174|Actinobacteria,236XA@1762|Mycobacteriaceae	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2330
TH2_k127_3501633_4	497964.CfE428DRAFT_2629	1.157e-80	282.0	COG0547@1|root,COG0547@2|Bacteria,46SQA@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
TH2_k127_3501633_0	553175.POREN0001_0433	2.772e-195	622.0	COG0442@1|root,COG0442@2|Bacteria,4NEAF@976|Bacteroidetes,2FMZT@200643|Bacteroidia,22X3K@171551|Porphyromonadaceae	976|Bacteroidetes	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017101,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
TH2_k127_3501633_5	1089552.KI911559_gene2258	3.435e-06	55.0	COG1664@1|root,COG1664@2|Bacteria	2|Bacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
TH2_k127_3514617_1	1185876.BN8_01058	1.5e-76	274.0	COG4733@1|root,COG4733@2|Bacteria,4NK2V@976|Bacteroidetes,47P6C@768503|Cytophagia	976|Bacteroidetes	G	PFAM Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	fn3
TH2_k127_3514617_2	593750.Metfor_2898	4.212e-16	90.0	COG0613@1|root,arCOG00302@2157|Archaea,2XSWE@28890|Euryarchaeota,2N9Q2@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART phosphoesterase PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP,PHP_C
TH2_k127_3514617_0	497964.CfE428DRAFT_4568	1.262e-100	338.0	28MGX@1|root,2ZATZ@2|Bacteria,46TJV@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3522199_10	1009370.ALO_09729	1.645e-08	60.0	COG0239@1|root,COG0239@2|Bacteria,1VEH7@1239|Firmicutes,4H4YH@909932|Negativicutes	909932|Negativicutes	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
TH2_k127_3522199_9	500632.CLONEX_00478	8.721e-11	70.0	COG1321@1|root,COG1321@2|Bacteria,1V4B0@1239|Firmicutes	1239|Firmicutes	K	Iron dependent repressor DNA binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fe_dep_repr_C,Fe_dep_repress
TH2_k127_3522199_12	1071073.KI530535_gene531	0.0005507	48.0	COG1633@1|root,COG1633@2|Bacteria,1V4ZN@1239|Firmicutes,4HH0Q@91061|Bacilli,1ZGWB@1386|Bacillus	91061|Bacilli	S	Ferritin-like domain	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
TH2_k127_3522199_1	1208321.D104_11940	2.366e-152	506.0	COG4772@1|root,COG4772@2|Bacteria,1MWDG@1224|Proteobacteria,1RQA5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	receptor	fecA	GO:0000041,GO:0003674,GO:0005215,GO:0005381,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0008150,GO:0008324,GO:0009279,GO:0015075,GO:0015091,GO:0015318,GO:0015682,GO:0016020,GO:0019867,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0030313,GO:0031975,GO:0034220,GO:0034755,GO:0044462,GO:0044464,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0072510,GO:0072512,GO:0098655,GO:0098660,GO:0098662	-	ko:K16091	-	-	-	-	ko00000,ko02000	1.B.14.1.14	-	iEC042_1314.EC042_4780	Plug,STN,TonB_dep_Rec
TH2_k127_3522199_3	32057.KB217478_gene6069	2.413e-53	201.0	COG3221@1|root,COG3221@2|Bacteria,1G2Q9@1117|Cyanobacteria,1HIGE@1161|Nostocales	1117|Cyanobacteria	P	TIGRFAM phosphate phosphite phosphonate ABC transporters, periplasmic binding protein	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
TH2_k127_3522199_4	1337936.IJ00_18290	2.559e-48	187.0	COG3638@1|root,COG3638@2|Bacteria,1G1FG@1117|Cyanobacteria,1HK5A@1161|Nostocales	1117|Cyanobacteria	P	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system	phnC	-	3.6.3.28	ko:K02041	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.9	-	-	ABC_tran
TH2_k127_3522199_2	118173.KB235914_gene3766	1.895e-67	241.0	COG3639@1|root,COG3639@2|Bacteria,1G2C0@1117|Cyanobacteria,1HHHB@1150|Oscillatoriales	1117|Cyanobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02042	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	BPD_transp_1
TH2_k127_3522199_5	926561.KB900617_gene1942	6.487e-40	156.0	COG0811@1|root,COG0811@2|Bacteria,1V49T@1239|Firmicutes	1239|Firmicutes	U	MotA TolQ ExbB proton channel	-	-	-	-	-	-	-	-	-	-	-	-	MotA_ExbB
TH2_k127_3522199_8	754027.HMPREF9554_02788	2.671e-15	83.0	COG0848@1|root,COG0848@2|Bacteria,2J7UG@203691|Spirochaetes	203691|Spirochaetes	U	protein, ExbD TolR family	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
TH2_k127_3522199_7	379731.PST_1713	1.841e-30	129.0	COG0810@1|root,COG0810@2|Bacteria,1MZPX@1224|Proteobacteria,1S6MH@1236|Gammaproteobacteria,1Z41M@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	M	Gram-negative bacterial TonB protein C-terminal	tonB2	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
TH2_k127_3522199_11	521674.Plim_2697	4.376e-06	52.0	COG1918@1|root,COG1918@2|Bacteria,2J0K6@203682|Planctomycetes	203682|Planctomycetes	P	COG1918 Fe2 transport system protein A	-	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
TH2_k127_3522199_0	243090.RB7130	4.651e-183	597.0	COG0370@1|root,COG0370@2|Bacteria,2IYCI@203682|Planctomycetes	203682|Planctomycetes	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
TH2_k127_3522199_6	497964.CfE428DRAFT_2172	2.045e-37	145.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,46SRG@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Competence-damaged protein	cinA	-	3.5.1.42	ko:K03742	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
TH2_k127_3528656_0	269799.Gmet_1566	1.821e-101	337.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,43DRR@68525|delta/epsilon subdivisions,2X70U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Cys Met metabolism	metY-3	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
TH2_k127_3531007_9	1254432.SCE1572_06800	3.234e-16	83.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,42M98@68525|delta/epsilon subdivisions,2WMKB@28221|Deltaproteobacteria,2YXV7@29|Myxococcales	28221|Deltaproteobacteria	L	HTH-like domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve
TH2_k127_3531007_11	1323663.AROI01000005_gene3049	1.994e-07	61.0	COG2963@1|root,COG2963@2|Bacteria,1MZ5C@1224|Proteobacteria,1S6RG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG2963 Transposase and inactivated derivatives	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
TH2_k127_3531007_4	1396418.BATQ01000024_gene5201	1.431e-73	256.0	COG4974@1|root,COG4974@2|Bacteria,46Z4R@74201|Verrucomicrobia,2IV5V@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	IS66 C-terminal element	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66
TH2_k127_3531007_6	177437.HRM2_45140	6.97e-34	144.0	COG1073@1|root,COG1073@2|Bacteria,1NEVB@1224|Proteobacteria,42W4K@68525|delta/epsilon subdivisions,2WRSK@28221|Deltaproteobacteria,2MN89@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Acetyl xylan esterase (AXE1)	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3531007_5	1232437.KL662047_gene5206	3.933e-57	215.0	COG4927@1|root,COG4927@2|Bacteria,1QSIY@1224|Proteobacteria,437I4@68525|delta/epsilon subdivisions,2X2RP@28221|Deltaproteobacteria,2MPB6@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	AAT
TH2_k127_3531007_0	324602.Caur_1163	7.338e-317	989.0	COG1449@1|root,COG1449@2|Bacteria,2G5XB@200795|Chloroflexi,3768X@32061|Chloroflexia	32061|Chloroflexia	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3536,Glyco_hydro_57
TH2_k127_3531007_13	1215092.PA6_024_00240	6.767e-05	49.0	2EGQR@1|root,33AGW@2|Bacteria,1NN0W@1224|Proteobacteria	1224|Proteobacteria	S	tRNA_anti-like	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_anti-like
TH2_k127_3531007_2	481448.Minf_1043	7.517e-125	407.0	COG0492@1|root,COG0492@2|Bacteria,46SC1@74201|Verrucomicrobia,37G4X@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	C	Pyridine nucleotide-disulphide oxidoreductase	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TH2_k127_3531007_1	497964.CfE428DRAFT_3619	2.083e-160	534.0	COG0515@1|root,COG4886@1|root,COG0515@2|Bacteria,COG4886@2|Bacteria,46VB0@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	FHA,Pkinase
TH2_k127_3531007_10	1210884.HG799473_gene14944	3.842e-14	84.0	COG2199@1|root,COG3706@2|Bacteria,2IZCN@203682|Planctomycetes	203682|Planctomycetes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GGDEF,Yop-YscD_cpl
TH2_k127_3531007_3	478741.JAFS01000002_gene955	1.453e-114	403.0	COG1033@1|root,COG1033@2|Bacteria,46Z86@74201|Verrucomicrobia,37G0Z@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
TH2_k127_3531007_12	1238182.C882_2510	4.748e-07	56.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,2TSFS@28211|Alphaproteobacteria,2JPAU@204441|Rhodospirillales	204441|Rhodospirillales	P	COG0471 Di- and tricarboxylate transporters	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
TH2_k127_3531007_8	278957.ABEA03000185_gene1567	2.653e-17	83.0	COG1959@1|root,COG1959@2|Bacteria,46SPI@74201|Verrucomicrobia,3K7XE@414999|Opitutae	414999|Opitutae	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
TH2_k127_3531007_7	234267.Acid_3742	4.488e-32	138.0	COG3408@1|root,COG3408@2|Bacteria,3Y7ET@57723|Acidobacteria	57723|Acidobacteria	G	Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H,Bac_rhamnosid_N
TH2_k127_3534642_8	497964.CfE428DRAFT_1202	7.265e-18	86.0	COG1254@1|root,COG1254@2|Bacteria,46W9W@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Belongs to the acylphosphatase family	acyP	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
TH2_k127_3534642_3	497964.CfE428DRAFT_1201	5.237e-91	308.0	COG1131@1|root,COG1131@2|Bacteria,46SHV@74201|Verrucomicrobia	74201|Verrucomicrobia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TH2_k127_3534642_6	497964.CfE428DRAFT_1200	2.22e-35	148.0	COG1277@1|root,COG1277@2|Bacteria,46VKD@74201|Verrucomicrobia	74201|Verrucomicrobia	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
TH2_k127_3534642_7	497964.CfE428DRAFT_1199	1.469e-28	125.0	COG0457@1|root,COG0457@2|Bacteria,46VY0@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3534642_2	497964.CfE428DRAFT_1198	6.743e-94	314.0	COG0639@1|root,COG0639@2|Bacteria,46TA5@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Calcineurin-like phosphoesterase superfamily domain	apaH	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
TH2_k127_3534642_4	671143.DAMO_1640	9.203e-75	262.0	COG0859@1|root,COG0859@2|Bacteria	2|Bacteria	M	ADP-heptose-lipopolysaccharide heptosyltransferase activity	-	-	-	ko:K02841,ko:K02843,ko:K02849,ko:K12982	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
TH2_k127_3534642_1	344747.PM8797T_00899	1.476e-189	603.0	COG0702@1|root,COG0702@2|Bacteria,2IYQV@203682|Planctomycetes	203682|Planctomycetes	GM	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
TH2_k127_3534642_9	1156937.MFUM_60009	9.872e-09	66.0	COG1196@1|root,COG1196@2|Bacteria,46Z83@74201|Verrucomicrobia,37GKF@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3534642_11	240292.Ava_4803	0.000185	55.0	COG0457@1|root,COG0457@2|Bacteria,1GHDC@1117|Cyanobacteria,1HRAS@1161|Nostocales	1117|Cyanobacteria	S	Anaphase-promoting complex, cyclosome, subunit 3	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_2
TH2_k127_3534642_5	204669.Acid345_3128	3.961e-37	161.0	COG1287@1|root,COG1287@2|Bacteria,3Y5FJ@57723|Acidobacteria,2JJV3@204432|Acidobacteriia	204432|Acidobacteriia	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3534642_0	382464.ABSI01000007_gene4180	6.757e-266	834.0	COG1217@1|root,COG1217@2|Bacteria,46SHA@74201|Verrucomicrobia,2ITJK@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	Elongation factor G C-terminus	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
TH2_k127_3534783_2	1396418.BATQ01000047_gene6177	4.292e-170	547.0	COG0165@1|root,COG0165@2|Bacteria,46SCX@74201|Verrucomicrobia,2ITKH@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Argininosuccinate lyase C-terminal	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
TH2_k127_3534783_12	869210.Marky_0201	3.671e-19	98.0	COG0639@1|root,COG0639@2|Bacteria,1WIHC@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	Metallophosphoesterase	-	-	3.1.3.16	ko:K01090	-	-	-	-	ko00000,ko01000	-	-	-	Metallophos_2
TH2_k127_3534783_7	867845.KI911784_gene3667	7.72e-58	211.0	COG0279@1|root,COG0279@2|Bacteria,2G6QD@200795|Chloroflexi,375VE@32061|Chloroflexia	32061|Chloroflexia	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
TH2_k127_3534783_0	240016.ABIZ01000001_gene1867	1.425e-190	616.0	COG0475@1|root,COG0475@2|Bacteria,46U4K@74201|Verrucomicrobia,2IV1A@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_C
TH2_k127_3534783_13	1121895.Q765_16430	3.027e-15	81.0	COG2259@1|root,COG2259@2|Bacteria,4NSHK@976|Bacteroidetes,1I45N@117743|Flavobacteriia,2NXDF@237|Flavobacterium	976|Bacteroidetes	S	DoxX	-	-	1.8.5.2	ko:K16937	ko00920,ko01120,map00920,map01120	-	R07177	-	ko00000,ko00001,ko01000	3.D.4.9	-	-	DoxX
TH2_k127_3534783_1	1267535.KB906767_gene1049	2.244e-177	569.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,3Y3IF@57723|Acidobacteria,2JIPC@204432|Acidobacteriia	204432|Acidobacteriia	HP	PFAM UBA THIF-type NAD FAD binding	-	-	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF,ThiS
TH2_k127_3534783_10	42256.RradSPS_2142	2.252e-32	134.0	COG1310@1|root,COG1310@2|Bacteria	2|Bacteria	S	proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
TH2_k127_3534783_4	1183438.GKIL_1944	4.387e-105	368.0	COG0031@1|root,COG0031@2|Bacteria,1GBK3@1117|Cyanobacteria	1117|Cyanobacteria	E	Cysteine synthase B	-	-	2.5.1.47	ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TH2_k127_3534783_3	1396418.BATQ01000091_gene5776	8.022e-125	412.0	COG0079@1|root,COG0079@2|Bacteria,46SFP@74201|Verrucomicrobia,2ITIN@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Aminotransferase class I and II	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TH2_k127_3534783_8	398767.Glov_2207	9.05e-44	171.0	COG1560@1|root,COG1560@2|Bacteria,1NJIN@1224|Proteobacteria,431MM@68525|delta/epsilon subdivisions,2WX1W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	lipid A biosynthesis acyltransferase	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
TH2_k127_3534783_5	760568.Desku_2549	1.351e-67	244.0	COG0707@1|root,COG0707@2|Bacteria,1UQ6A@1239|Firmicutes,248FR@186801|Clostridia,2612Z@186807|Peptococcaceae	186801|Clostridia	M	PFAM Glycosyltransferase family 28 C-terminal domain	ugtP	-	2.4.1.315	ko:K03429	ko00561,ko01100,map00561,map01100	-	R02689,R04377	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT28	-	Glyco_tran_28_C,Glycos_transf_1,MGDG_synth
TH2_k127_3534783_9	478741.JAFS01000001_gene1519	4.375e-34	133.0	COG1141@1|root,COG1141@2|Bacteria,46T2D@74201|Verrucomicrobia,37GX8@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	C	4Fe-4S single cluster domain of Ferredoxin I	-	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13
TH2_k127_3534783_14	497964.CfE428DRAFT_2403	8.137e-12	74.0	COG5512@1|root,COG5512@2|Bacteria,46WKB@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
TH2_k127_3534783_11	1328313.DS2_06231	1.972e-21	108.0	COG3271@1|root,COG3271@2|Bacteria,1RA3D@1224|Proteobacteria,1S2EC@1236|Gammaproteobacteria,4656G@72275|Alteromonadaceae	1236|Gammaproteobacteria	NU	Peptidase_C39 like family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C39_2,TPR_16
TH2_k127_3534783_6	1191523.MROS_1603	9.614e-62	222.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	mhpC	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
TH2_k127_354816_0	1411685.U062_01756	2.733e-75	264.0	COG3380@1|root,COG3380@2|Bacteria,1R5C0@1224|Proteobacteria,1S3X1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers	-	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050664,GO:0051287,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363	-	ko:K06955	-	-	-	-	ko00000	-	-	-	Amino_oxidase,NAD_binding_8
TH2_k127_3555019_1	1123274.KB899411_gene3184	5.047e-70	245.0	COG0451@1|root,COG0451@2|Bacteria,2J5DY@203691|Spirochaetes	203691|Spirochaetes	GM	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TH2_k127_3555019_0	1444309.JAQG01000115_gene3195	1.577e-152	493.0	COG0160@1|root,COG0160@2|Bacteria,1VS6F@1239|Firmicutes,4H9M7@91061|Bacilli,26T4S@186822|Paenibacillaceae	91061|Bacilli	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.22	ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TH2_k127_3555019_2	395961.Cyan7425_1835	1.024e-31	129.0	COG1748@1|root,COG1748@2|Bacteria,1G37A@1117|Cyanobacteria	1117|Cyanobacteria	E	Saccharopine dehydrogenase C-terminal domain	-	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
TH2_k127_3592396_1	313624.NSP_52870	5.879e-48	177.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1FZWQ@1117|Cyanobacteria,1HKIQ@1161|Nostocales	1117|Cyanobacteria	KLT	PFAM Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,Pkinase
TH2_k127_3592396_2	1444712.BN1013_02216	5.545e-26	115.0	2DQ8V@1|root,32UNN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
TH2_k127_3592396_0	278957.ABEA03000099_gene860	7.937e-51	197.0	2CAB8@1|root,33EYG@2|Bacteria,46XII@74201|Verrucomicrobia,3K9KC@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3680415_6	1396418.BATQ01000156_gene5584	5.333e-12	74.0	2EGCD@1|root,33A46@2|Bacteria,46Z2P@74201|Verrucomicrobia,2IWC7@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Domain of unknown function (DUF4190)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190,DUF4339
TH2_k127_3680415_3	760568.Desku_3202	6.291e-68	243.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1TQCU@1239|Firmicutes,248CK@186801|Clostridia,260CI@186807|Peptococcaceae	186801|Clostridia	HK	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
TH2_k127_3680415_4	497964.CfE428DRAFT_5015	1.081e-62	226.0	COG1521@1|root,COG1521@2|Bacteria,46T0X@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
TH2_k127_3680415_2	382464.ABSI01000010_gene3811	2.696e-68	241.0	COG0159@1|root,COG0159@2|Bacteria,46SK1@74201|Verrucomicrobia,2ITJI@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
TH2_k127_3680415_1	697281.Mahau_2339	1.007e-87	308.0	COG0836@1|root,COG0836@2|Bacteria,1TPC9@1239|Firmicutes,24908@186801|Clostridia,42FA6@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Nucleotidyl transferase	-	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
TH2_k127_3680415_5	706587.Desti_1498	3.533e-27	115.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,42UC6@68525|delta/epsilon subdivisions,2WPDD@28221|Deltaproteobacteria,2MS8A@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
TH2_k127_3680415_0	335543.Sfum_2944	3.69e-123	402.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,43DP2@68525|delta/epsilon subdivisions,2X261@28221|Deltaproteobacteria,2MRR5@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
TH2_k127_3680415_8	1352941.M877_13315	0.0002028	52.0	COG2234@1|root,COG2234@2|Bacteria,2I9BM@201174|Actinobacteria	201174|Actinobacteria	G	Peptidase, M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
TH2_k127_3680415_7	59374.Fisuc_1806	1.025e-05	51.0	2DTZ9@1|root,33NAR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3680415_9	180332.JTGN01000016_gene1071	0.0009687	42.0	COG2378@1|root,COG2378@2|Bacteria,1TT23@1239|Firmicutes,248A8@186801|Clostridia	186801|Clostridia	K	HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
TH2_k127_3708937_6	526227.Mesil_2966	6.53e-65	224.0	COG4813@1|root,COG4813@2|Bacteria,1WM7Y@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	ThuA
TH2_k127_3708937_2	926569.ANT_06980	5.642e-162	522.0	COG0673@1|root,COG0673@2|Bacteria,2G6KB@200795|Chloroflexi	200795|Chloroflexi	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TH2_k127_3708937_7	382464.ABSI01000020_gene118	5.036e-55	207.0	COG3878@1|root,COG3878@2|Bacteria	2|Bacteria	J	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1963
TH2_k127_3708937_3	316067.Geob_2507	3.656e-138	458.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2WIR6@28221|Deltaproteobacteria,43U1S@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Beta-eliminating lyase	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
TH2_k127_3708937_8	765420.OSCT_1552	6.123e-38	160.0	COG5607@1|root,COG5607@2|Bacteria,2G7FA@200795|Chloroflexi,375SS@32061|Chloroflexia	32061|Chloroflexia	FP	PFAM CHAD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH,HD
TH2_k127_3708937_10	671143.DAMO_0425	5.841e-22	100.0	COG3646@1|root,COG3646@2|Bacteria	2|Bacteria	L	Phage regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	ORF6N
TH2_k127_3708937_15	270374.MELB17_03180	3.744e-05	48.0	COG1637@1|root,COG3680@1|root,COG1637@2|Bacteria,COG3680@2|Bacteria,1R7PZ@1224|Proteobacteria	1224|Proteobacteria	L	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures	-	-	-	ko:K09968	-	-	-	-	ko00000	-	-	-	-
TH2_k127_3708937_1	1499967.BAYZ01000166_gene6618	4.661e-191	600.0	COG0524@1|root,COG0524@2|Bacteria	2|Bacteria	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
TH2_k127_3708937_4	861299.J421_0712	4.549e-135	436.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TH2_k127_3708937_0	497964.CfE428DRAFT_0257	2.863e-245	790.0	COG2844@1|root,COG2844@2|Bacteria,46SI6@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	DUF294,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
TH2_k127_3708937_5	1156937.MFUM_230006	1.047e-121	414.0	COG1956@1|root,COG2203@1|root,COG4191@1|root,COG1956@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,46SAZ@74201|Verrucomicrobia,37G69@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA
TH2_k127_3708937_17	452637.Oter_4189	0.0006682	47.0	28VHX@1|root,2ZHKC@2|Bacteria,46WNI@74201|Verrucomicrobia,3K9TV@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3708937_16	445335.CBN_A0062	4.849e-05	48.0	2ERMT@1|root,33J79@2|Bacteria,1VKZE@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3708937_9	498761.HM1_3148	1.256e-22	99.0	2DN97@1|root,32W7A@2|Bacteria,1VANB@1239|Firmicutes,24Q9J@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3708937_14	927677.ALVU02000001_gene2649	7.315e-11	63.0	2EK6X@1|root,33DXA@2|Bacteria,1GFHH@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_381280_7	457570.Nther_2233	0.0002298	44.0	COG1699@1|root,COG1699@2|Bacteria,1VA6Y@1239|Firmicutes,24QXE@186801|Clostridia	186801|Clostridia	S	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum	fliW	-	-	ko:K13626	-	-	-	-	ko00000,ko02035	-	-	-	FliW
TH2_k127_381280_6	1122921.KB898200_gene3239	6.845e-14	74.0	COG1551@1|root,COG1551@2|Bacteria,1VEEF@1239|Firmicutes,4HNPJ@91061|Bacilli,26ZW4@186822|Paenibacillaceae	91061|Bacilli	T	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding	csrA	-	-	ko:K03563	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03019	-	-	-	CsrA
TH2_k127_381280_2	946483.Cenrod_2073	1.537e-96	362.0	COG0438@1|root,COG0457@1|root,COG2242@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,COG2242@2|Bacteria,1N5N9@1224|Proteobacteria,2VVSK@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
TH2_k127_381280_5	706587.Desti_3637	3.519e-29	139.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glycos_transf_2,RgpF,Rhamno_transf
TH2_k127_381280_3	88036.EFJ19555	1.4e-82	316.0	COG0438@1|root,2QQT3@2759|Eukaryota,37K3J@33090|Viridiplantae,3GA4Y@35493|Streptophyta	35493|Streptophyta	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1
TH2_k127_381280_1	580327.Tthe_2187	7.014e-108	399.0	COG0438@1|root,COG0457@1|root,COG0463@1|root,COG1216@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,COG0463@2|Bacteria,COG1216@2|Bacteria,1TQEM@1239|Firmicutes,249HH@186801|Clostridia,42JEF@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,TPR_16,TPR_2,TPR_8
TH2_k127_381280_0	452637.Oter_0301	1.033e-169	540.0	COG0500@1|root,COG2226@2|Bacteria,46TWV@74201|Verrucomicrobia	2|Bacteria	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
TH2_k127_381280_4	452637.Oter_0303	5.951e-71	249.0	COG0306@1|root,COG0306@2|Bacteria	2|Bacteria	P	phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
TH2_k127_38157_0	1121918.ARWE01000001_gene2083	1.615e-158	507.0	COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,42M0Z@68525|delta/epsilon subdivisions,2WK36@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM Bile acid sodium symporter	arsB	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
TH2_k127_38157_6	1379270.AUXF01000001_gene2712	3.377e-24	107.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	arsR	GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0046685,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
TH2_k127_38157_5	1396141.BATP01000003_gene5267	1.542e-48	177.0	COG0394@1|root,COG0394@2|Bacteria,46T52@74201|Verrucomicrobia,2IUEU@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	Low molecular weight phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	LMWPc
TH2_k127_38157_7	452637.Oter_4107	1.404e-13	72.0	2DDH0@1|root,2ZI28@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_38157_1	1396141.BATP01000004_gene5882	4.476e-149	491.0	COG2059@1|root,COG2059@2|Bacteria,46V8S@74201|Verrucomicrobia,2IUYF@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Chromate transporter	-	-	-	-	-	-	-	-	-	-	-	-	Chromate_transp
TH2_k127_38157_3	517418.Ctha_1579	5.272e-86	296.0	COG5459@1|root,COG5459@2|Bacteria	2|Bacteria	J	Ribosomal small subunit Rsm22	-	-	-	-	-	-	-	-	-	-	-	-	Rsm22
TH2_k127_38157_4	234267.Acid_7125	1.486e-78	264.0	COG0662@1|root,COG0662@2|Bacteria,3Y6AM@57723|Acidobacteria	57723|Acidobacteria	G	Mannose-6-phosphate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TH2_k127_38157_2	1121481.AUAS01000006_gene837	9.167e-89	297.0	COG0673@1|root,COG0673@2|Bacteria,4NKJ1@976|Bacteroidetes,47JK9@768503|Cytophagia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TH2_k127_3824233_0	935567.JAES01000041_gene836	0.0001261	51.0	2EKDF@1|root,33E3R@2|Bacteria,1P7IA@1224|Proteobacteria,1SVDW@1236|Gammaproteobacteria,1X8X9@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3832985_12	573.JG24_06260	6.035e-145	471.0	COG1085@1|root,COG1085@2|Bacteria,1MU3E@1224|Proteobacteria,1RMDK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	galactose-1-phosphate uridylyltransferase	galT	GO:0003674,GO:0003824,GO:0004335,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006012,GO:0006793,GO:0006796,GO:0008108,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0019200,GO:0019318,GO:0019320,GO:0019388,GO:0033499,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046835,GO:0046872,GO:0046914,GO:0070569,GO:0071704,GO:1901575	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iECUMN_1333.ECUMN_0842,iYL1228.KPN_00772	GalP_UDP_tr_C,GalP_UDP_transf
TH2_k127_3832985_14	1144275.COCOR_02904	2.555e-143	468.0	COG0153@1|root,COG0153@2|Bacteria,1MVQD@1224|Proteobacteria,42Y39@68525|delta/epsilon subdivisions,2WSYZ@28221|Deltaproteobacteria,2YV2T@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the GHMP kinase family. GalK subfamily	galK	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
TH2_k127_3832985_8	671143.DAMO_2498	1.315e-149	482.0	COG1180@1|root,COG1180@2|Bacteria,2NP82@2323|unclassified Bacteria	2|Bacteria	O	Radical SAM superfamily	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
TH2_k127_3832985_47	903818.KI912268_gene1372	2.807e-07	63.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
TH2_k127_3832985_46	596152.DesU5LDRAFT_2941	8.376e-21	107.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,42MPK@68525|delta/epsilon subdivisions,2WJM1@28221|Deltaproteobacteria,2M7YN@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	PFAM PpiC-type peptidyl-prolyl cis-trans isomerase	nifM	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
TH2_k127_3832985_16	1449338.JQLU01000005_gene2142	9.816e-132	430.0	COG0082@1|root,COG0082@2|Bacteria,1TQ40@1239|Firmicutes,4HA0H@91061|Bacilli,27FWN@186828|Carnobacteriaceae	91061|Bacilli	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
TH2_k127_3832985_29	497964.CfE428DRAFT_2138	3.561e-64	245.0	COG1989@1|root,COG1989@2|Bacteria,46TWT@74201|Verrucomicrobia	74201|Verrucomicrobia	NOU	Type IV leader peptidase family	-	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
TH2_k127_3832985_27	1121423.JONT01000007_gene609	2.169e-66	237.0	COG0169@1|root,COG0169@2|Bacteria,1TQRY@1239|Firmicutes,2497S@186801|Clostridia,2619R@186807|Peptococcaceae	186801|Clostridia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
TH2_k127_3832985_19	1267534.KB906754_gene3770	2.143e-120	406.0	COG1007@1|root,COG1007@2|Bacteria,3Y73U@57723|Acidobacteria,2JMM8@204432|Acidobacteriia	204432|Acidobacteriia	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TH2_k127_3832985_5	1267534.KB906754_gene3771	6.017e-166	536.0	COG1008@1|root,COG1008@2|Bacteria,3Y6FA@57723|Acidobacteria,2JM6J@204432|Acidobacteriia	204432|Acidobacteriia	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TH2_k127_3832985_9	1267534.KB906754_gene3772	3.409e-148	486.0	COG1008@1|root,COG1008@2|Bacteria,3Y6ZF@57723|Acidobacteria,2JMB1@204432|Acidobacteriia	204432|Acidobacteriia	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TH2_k127_3832985_3	1267534.KB906754_gene3773	1.269e-197	637.0	COG1009@1|root,COG1009@2|Bacteria,3Y76V@57723|Acidobacteria,2JMJJ@204432|Acidobacteriia	204432|Acidobacteriia	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
TH2_k127_3832985_44	1267534.KB906754_gene3774	3.328e-25	110.0	COG0713@1|root,COG0713@2|Bacteria,3Y835@57723|Acidobacteria,2JN5T@204432|Acidobacteriia	204432|Acidobacteriia	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	-	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
TH2_k127_3832985_45	316274.Haur_4986	5.505e-24	113.0	COG0839@1|root,COG0839@2|Bacteria,2G777@200795|Chloroflexi,375K1@32061|Chloroflexia	32061|Chloroflexia	C	Belongs to the complex I subunit 6 family	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
TH2_k127_3832985_20	240015.ACP_2570	7.86e-119	393.0	COG1005@1|root,COG1005@2|Bacteria,3Y6TS@57723|Acidobacteria,2JKJQ@204432|Acidobacteriia	204432|Acidobacteriia	C	NADH dehydrogenase	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
TH2_k127_3832985_31	794903.OPIT5_21975	2.599e-60	224.0	COG1143@1|root,COG1143@2|Bacteria,46YB4@74201|Verrucomicrobia,3K98S@414999|Opitutae	414999|Opitutae	C	4Fe-4S binding domain	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
TH2_k127_3832985_4	240015.ACP_2568	5.604e-173	550.0	COG0649@1|root,COG0649@2|Bacteria,3Y6MU@57723|Acidobacteria,2JKN7@204432|Acidobacteriia	204432|Acidobacteriia	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
TH2_k127_3832985_32	1267534.KB906754_gene3779	8.11e-58	207.0	COG0852@1|root,COG0852@2|Bacteria,3Y72R@57723|Acidobacteria,2JM53@204432|Acidobacteriia	204432|Acidobacteriia	C	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	-	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
TH2_k127_3832985_24	240015.ACP_2566	2.051e-90	308.0	COG0377@1|root,COG0377@2|Bacteria,3Y74G@57723|Acidobacteria,2JKT1@204432|Acidobacteriia	204432|Acidobacteriia	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
TH2_k127_3832985_42	316274.Haur_4980	1.739e-33	134.0	COG0838@1|root,COG0838@2|Bacteria,2G71E@200795|Chloroflexi,375NS@32061|Chloroflexia	32061|Chloroflexia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
TH2_k127_3832985_37	443144.GM21_2428	1.899e-42	175.0	COG1082@1|root,COG1082@2|Bacteria,1NHXC@1224|Proteobacteria	1224|Proteobacteria	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TH2_k127_3832985_26	1463857.JOFZ01000015_gene933	7.682e-74	259.0	COG1082@1|root,COG1082@2|Bacteria,2GK34@201174|Actinobacteria	201174|Actinobacteria	G	Xylose isomerase	-	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	AP_endonuc_2
TH2_k127_3832985_40	478741.JAFS01000002_gene851	9.297e-36	144.0	COG0095@1|root,COG0095@2|Bacteria,46T01@74201|Verrucomicrobia,37GRJ@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	H	Biotin/lipoate A/B protein ligase family	lplA	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
TH2_k127_3832985_13	452637.Oter_3889	1.495e-144	465.0	COG2025@1|root,COG2025@2|Bacteria	2|Bacteria	C	fatty acid beta-oxidation using acyl-CoA dehydrogenase	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	Acyl-CoA_dh_1,ETF,ETF_alpha
TH2_k127_3832985_18	452637.Oter_3888	4.078e-124	404.0	COG2086@1|root,COG2086@2|Bacteria	2|Bacteria	C	electron transfer activity	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
TH2_k127_3832985_2	452637.Oter_3887	1.921e-285	889.0	COG0644@1|root,COG1145@1|root,COG0644@2|Bacteria,COG1145@2|Bacteria,46WP0@74201|Verrucomicrobia	74201|Verrucomicrobia	C	oxidoreductase	-	-	1.5.5.1	ko:K00311,ko:K00313	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_3
TH2_k127_3832985_0	234267.Acid_0094	0.0	1086.0	COG1960@1|root,COG1960@2|Bacteria	2|Bacteria	I	acyl-CoA dehydrogenase activity	fadE23	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TH2_k127_3832985_25	1173263.Syn7502_00476	4.781e-77	267.0	COG0854@1|root,COG0854@2|Bacteria,1G0QW@1117|Cyanobacteria,1GZKF@1129|Synechococcus	1117|Cyanobacteria	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
TH2_k127_3832985_41	1396141.BATP01000013_gene2682	2.419e-34	143.0	COG0736@1|root,COG0736@2|Bacteria,46T5U@74201|Verrucomicrobia,2IUTE@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	4'-phosphopantetheinyl transferase superfamily	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
TH2_k127_3832985_22	502025.Hoch_4153	1.461e-117	394.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YUJ9@29|Myxococcales	28221|Deltaproteobacteria	T	Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	pilR	-	-	ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH2_k127_3832985_38	398767.Glov_2632	7.188e-38	159.0	COG4191@1|root,COG4191@2|Bacteria,1P0U1@1224|Proteobacteria,42PTP@68525|delta/epsilon subdivisions,2WJ8U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TH2_k127_3832985_33	498761.HM1_2129	5.937e-56	204.0	COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,247J3@186801|Clostridia	186801|Clostridia	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
TH2_k127_3832985_30	240016.ABIZ01000001_gene2279	9.157e-62	218.0	COG0452@1|root,COG0452@2|Bacteria,46SPU@74201|Verrucomicrobia,2IUB8@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	Flavoprotein	-	-	4.1.1.36	ko:K01598	ko00770,ko01100,map00770,map01100	M00120	R03269	RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
TH2_k127_3832985_34	1158318.ATXC01000002_gene1464	2.561e-54	197.0	COG0194@1|root,COG0194@2|Bacteria,2G3ZQ@200783|Aquificae	200783|Aquificae	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
TH2_k127_3832985_23	497964.CfE428DRAFT_4161	5.597e-93	317.0	COG1561@1|root,COG1561@2|Bacteria,46TP9@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function (DUF1732)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
TH2_k127_3832985_7	1142394.PSMK_15220	1.611e-160	528.0	COG0143@1|root,COG0143@2|Bacteria,2IXD4@203682|Planctomycetes	203682|Planctomycetes	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
TH2_k127_3832985_6	497964.CfE428DRAFT_5496	9.802e-166	558.0	COG0553@1|root,COG0553@2|Bacteria,46TSJ@74201|Verrucomicrobia	74201|Verrucomicrobia	L	SNF2 family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N,SNF2_assoc
TH2_k127_3832985_21	204669.Acid345_3613	1.589e-118	393.0	COG0451@1|root,COG0451@2|Bacteria,3Y7M9@57723|Acidobacteria,2JMWH@204432|Acidobacteriia	204432|Acidobacteriia	M	Male sterility protein	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
TH2_k127_3832985_1	765952.PUV_14580	3.156e-310	962.0	COG0365@1|root,COG0365@2|Bacteria,2JFRM@204428|Chlamydiae	204428|Chlamydiae	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
TH2_k127_3832985_39	382464.ABSI01000010_gene3441	1.093e-37	153.0	COG2197@1|root,COG2197@2|Bacteria,46V5Z@74201|Verrucomicrobia,2IUBG@203494|Verrucomicrobiae	74201|Verrucomicrobia	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TH2_k127_3832985_48	1000565.METUNv1_00201	3.86e-05	51.0	COG4585@1|root,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,2VJR2@28216|Betaproteobacteria,2KWPD@206389|Rhodocyclales	206389|Rhodocyclales	T	Histidine kinase	-	-	2.7.13.1	ko:K05962	-	-	-	-	ko00000,ko01000	-	-	-	CHASE3,HATPase_c,HisKA_3
TH2_k127_3832985_15	1347369.CCAD010000080_gene3106	7.66e-133	434.0	COG1626@1|root,COG1626@2|Bacteria,1UNMZ@1239|Firmicutes	1239|Firmicutes	G	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3832985_10	340177.Cag_0787	3.452e-146	480.0	COG1785@1|root,COG1785@2|Bacteria	2|Bacteria	P	alkaline phosphatase activity	-	-	3.1.3.1,3.1.4.46	ko:K01077,ko:K01126	ko00564,ko00730,ko00790,ko01100,ko02020,map00564,map00730,map00790,map01100,map02020	M00126	R01030,R01470,R02135,R04620	RC00017,RC00425	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase,Big_5
TH2_k127_3832985_11	247490.KSU1_C1279	5.387e-146	472.0	COG0535@1|root,COG0535@2|Bacteria,2IZE3@203682|Planctomycetes	203682|Planctomycetes	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
TH2_k127_3832985_28	1191523.MROS_2095	3.183e-65	239.0	COG0646@1|root,COG0646@2|Bacteria	2|Bacteria	E	methionine synthase	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
TH2_k127_3832985_36	590998.Celf_1077	1.514e-46	177.0	COG1349@1|root,COG1349@2|Bacteria,2GKWM@201174|Actinobacteria,4F32F@85016|Cellulomonadaceae	201174|Actinobacteria	K	DeoR C terminal sensor domain	fruR	-	-	ko:K03436	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
TH2_k127_3832985_17	158190.SpiGrapes_1326	2.698e-127	436.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,2JA17@203691|Spirochaetes	203691|Spirochaetes	C	Dehydrogenase E1 component	-	-	1.2.4.1,1.2.4.4	ko:K00162,ko:K11381	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
TH2_k127_3832985_35	671143.DAMO_0425	1.215e-47	193.0	COG3646@1|root,COG3646@2|Bacteria	2|Bacteria	L	Phage regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	ORF6N
TH2_k127_3849060_4	382464.ABSI01000016_gene705	1.412e-09	64.0	COG1868@1|root,COG1868@2|Bacteria	2|Bacteria	N	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliM	-	-	ko:K02416,ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FliM,FliMN_C
TH2_k127_3849060_2	635013.TherJR_1529	8.614e-20	91.0	COG1776@1|root,COG1886@1|root,COG1776@2|Bacteria,COG1886@2|Bacteria,1TPT8@1239|Firmicutes,24821@186801|Clostridia,260PZ@186807|Peptococcaceae	186801|Clostridia	N	PFAM surface presentation of antigens (SPOA)	fliN	-	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	CheC,FliMN_C
TH2_k127_3849060_5	767434.Fraau_2087	3.207e-05	54.0	COG3190@1|root,COG3190@2|Bacteria,1NHJX@1224|Proteobacteria,1SX47@1236|Gammaproteobacteria,1X88A@135614|Xanthomonadales	135614|Xanthomonadales	N	flagellar	fliO	-	-	ko:K02418	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliO
TH2_k127_3849060_0	452637.Oter_0409	1.647e-73	264.0	COG1338@1|root,COG1338@2|Bacteria,46USW@74201|Verrucomicrobia,3K7PQ@414999|Opitutae	414999|Opitutae	N	Plays a role in the flagellum-specific transport system	fliP	-	-	ko:K02419	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliP
TH2_k127_3849060_3	665571.STHERM_c09270	3.544e-17	83.0	COG1987@1|root,COG1987@2|Bacteria,2J93G@203691|Spirochaetes	203691|Spirochaetes	N	Role in flagellar biosynthesis	fliQ	-	-	ko:K02420	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_3
TH2_k127_3849060_1	794903.OPIT5_24905	2.867e-22	107.0	COG1684@1|root,COG1684@2|Bacteria,46WEA@74201|Verrucomicrobia,3K852@414999|Opitutae	414999|Opitutae	NU	Bacterial export proteins, family 1	-	-	-	ko:K02421	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1
TH2_k127_3866682_0	118168.MC7420_1277	1.646e-39	171.0	28N1B@1|root,2ZB7I@2|Bacteria,1G011@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_387080_4	489825.LYNGBM3L_21190	4.652e-29	119.0	COG0438@1|root,COG0438@2|Bacteria,1GC2Y@1117|Cyanobacteria	1117|Cyanobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_387080_0	1303518.CCALI_01720	4.266e-178	586.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
TH2_k127_387080_6	1236504.HMPREF2132_10615	2.153e-16	81.0	COG3620@1|root,COG3620@2|Bacteria,4NV6Z@976|Bacteroidetes,2FUN7@200643|Bacteroidia	976|Bacteroidetes	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
TH2_k127_387080_5	1410633.JHWR01000001_gene1368	3.807e-24	107.0	COG3550@1|root,COG3550@2|Bacteria,1VAEP@1239|Firmicutes,24PQ5@186801|Clostridia,27NMD@186928|unclassified Lachnospiraceae	186801|Clostridia	S	HipA N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Couple_hipA
TH2_k127_387080_1	933262.AXAM01000182_gene2067	3.907e-75	265.0	COG3550@1|root,COG3550@2|Bacteria,1RHBA@1224|Proteobacteria,42VDG@68525|delta/epsilon subdivisions,2X5H7@28221|Deltaproteobacteria,2MKX7@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Pfam:HipA_N	-	-	2.7.11.1	ko:K07154	-	-	-	-	ko00000,ko01000,ko01001,ko02048	-	-	-	Couple_hipA,HipA_C
TH2_k127_387080_7	765912.Thimo_1008	7.225e-13	83.0	296NP@1|root,2ZTXS@2|Bacteria	2|Bacteria	S	Heparinase II/III-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Hepar_II_III
TH2_k127_387080_3	864051.BurJ1DRAFT_0558	3.768e-31	126.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,2VRC4@28216|Betaproteobacteria,1KKP8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
TH2_k127_387080_2	380394.Lferr_0309	7.031e-67	246.0	COG5433@1|root,COG5433@2|Bacteria,1RAHU@1224|Proteobacteria,1S1TZ@1236|Gammaproteobacteria,2NDWK@225057|Acidithiobacillales	1236|Gammaproteobacteria	L	DDE_Tnp_1-associated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc,DUF4338
TH2_k127_3903888_20	1173264.KI913949_gene1938	5.33e-10	66.0	COG1401@1|root,COG1401@2|Bacteria,1G4CK@1117|Cyanobacteria,1HHNT@1150|Oscillatoriales	1117|Cyanobacteria	V	restriction endodeoxyribonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
TH2_k127_3903888_6	278957.ABEA03000197_gene447	1.173e-100	334.0	COG4786@1|root,COG4786@2|Bacteria,46UIV@74201|Verrucomicrobia,3K75R@414999|Opitutae	414999|Opitutae	N	Flagella basal body rod protein	-	-	-	ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
TH2_k127_3903888_21	1123519.PSJM300_06325	4.741e-09	66.0	COG1261@1|root,COG1261@2|Bacteria,1N1SA@1224|Proteobacteria,1S8SQ@1236|Gammaproteobacteria,1Z2NY@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	N	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly	flgA	-	-	ko:K02386	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	ChapFlgA
TH2_k127_3903888_10	794903.OPIT5_25000	4.881e-43	166.0	COG2063@1|root,COG2063@2|Bacteria,46VP3@74201|Verrucomicrobia,3K818@414999|Opitutae	414999|Opitutae	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgH	-	-	ko:K02393	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgH
TH2_k127_3903888_5	794903.OPIT5_24995	1.209e-119	402.0	COG1706@1|root,COG1706@2|Bacteria,46TDB@74201|Verrucomicrobia,3K78D@414999|Opitutae	414999|Opitutae	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgI	-	-	ko:K02394	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgI
TH2_k127_3903888_22	1096930.L284_06610	2.542e-06	57.0	COG3951@1|root,COG3951@2|Bacteria,1NG9S@1224|Proteobacteria,2UJMF@28211|Alphaproteobacteria,2K7KR@204457|Sphingomonadales	204457|Sphingomonadales	MNO	Rod binding protein	-	-	-	ko:K02395	-	-	-	-	ko00000,ko02035	-	-	-	Rod-binding
TH2_k127_3903888_18	278957.ABEA03000198_gene4168	6.492e-11	72.0	2FIUS@1|root,34AK6@2|Bacteria,46WE9@74201|Verrucomicrobia,3K8CJ@414999|Opitutae	414999|Opitutae	S	FlgN protein	-	-	-	-	-	-	-	-	-	-	-	-	FlgN
TH2_k127_3903888_7	330214.NIDE2319	1.642e-66	250.0	COG1256@1|root,COG4786@1|root,COG1256@2|Bacteria,COG4786@2|Bacteria,3J0M9@40117|Nitrospirae	40117|Nitrospirae	N	Flagellar basal body rod FlgEFG protein C-terminal	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
TH2_k127_3903888_16	1120972.AUMH01000031_gene997	2.701e-20	102.0	COG1344@1|root,COG1344@2|Bacteria,1TPDT@1239|Firmicutes,4HCCZ@91061|Bacilli,278AV@186823|Alicyclobacillaceae	91061|Bacilli	N	Belongs to the bacterial flagellin family	flgL	GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464	-	ko:K02397	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
TH2_k127_3903888_17	1396141.BATP01000003_gene5171	3.572e-20	96.0	2DSKE@1|root,33GH9@2|Bacteria,46XPR@74201|Verrucomicrobia,2IWC4@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3903888_11	439235.Dalk_0653	9.743e-43	175.0	COG1639@1|root,COG1639@2|Bacteria,1RCW6@1224|Proteobacteria,43AQW@68525|delta/epsilon subdivisions,2X64U@28221|Deltaproteobacteria,2MPGS@213118|Desulfobacterales	28221|Deltaproteobacteria	T	SMART metal-dependent phosphohydrolase HD region	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
TH2_k127_3903888_2	234267.Acid_2264	3.485e-186	595.0	COG5492@1|root,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_2,PSCyt2,PSD1
TH2_k127_3903888_1	234267.Acid_2265	4.938e-200	632.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
TH2_k127_3903888_3	234267.Acid_2266	4.087e-150	503.0	COG2319@1|root,COG2319@2|Bacteria	2|Bacteria	S	anaphase-promoting complex binding	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,WD40
TH2_k127_3903888_8	666509.RCA23_c03800	1.178e-59	220.0	COG3239@1|root,COG3239@2|Bacteria,1R42Z@1224|Proteobacteria,2TU07@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
TH2_k127_3903888_9	666509.RCA23_c03800	6.972e-56	209.0	COG3239@1|root,COG3239@2|Bacteria,1R42Z@1224|Proteobacteria,2TU07@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
TH2_k127_3903888_12	1122915.AUGY01000009_gene4895	2.416e-42	167.0	COG2207@1|root,COG2207@2|Bacteria,1UJEW@1239|Firmicutes,4IT7C@91061|Bacilli,26WC5@186822|Paenibacillaceae	91061|Bacilli	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
TH2_k127_3903888_4	234267.Acid_7187	2.397e-143	482.0	COG0457@1|root,COG0457@2|Bacteria,3Y3RA@57723|Acidobacteria	57723|Acidobacteria	M	SMART Tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8
TH2_k127_3903888_14	243231.GSU0672	1.427e-27	121.0	COG1102@1|root,COG1102@2|Bacteria,1R9XZ@1224|Proteobacteria,43766@68525|delta/epsilon subdivisions,2X252@28221|Deltaproteobacteria,43SV0@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
TH2_k127_3903888_15	207559.Dde_0984	1.861e-21	109.0	COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,42TII@68525|delta/epsilon subdivisions,2WPVK@28221|Deltaproteobacteria,2MBW9@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
TH2_k127_3903888_0	264732.Moth_2378	2.826e-222	698.0	COG0055@1|root,COG0055@2|Bacteria,1TPGF@1239|Firmicutes,2489W@186801|Clostridia,42F1X@68295|Thermoanaerobacterales	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
TH2_k127_3903888_13	1237149.C900_04403	9.371e-28	117.0	COG0399@1|root,COG0399@2|Bacteria,4NS7A@976|Bacteroidetes,47X4X@768503|Cytophagia	976|Bacteroidetes	J	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
TH2_k127_3903888_19	318161.Sden_3753	8.532e-11	63.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,1RNWJ@1236|Gammaproteobacteria,2Q8N3@267890|Shewanellaceae	1236|Gammaproteobacteria	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iSSON_1240.SSON_3886,iYL1228.KPN_04138	ATP-synt
TH2_k127_3917504_1	234267.Acid_0580	0.0001759	53.0	COG1463@1|root,COG1463@2|Bacteria,3Y3SX@57723|Acidobacteria	57723|Acidobacteria	Q	PFAM Mammalian cell entry related domain protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
TH2_k127_3917504_0	1396418.BATQ01000025_gene5262	3.248e-101	347.0	COG0520@1|root,COG0520@2|Bacteria,46SC0@74201|Verrucomicrobia,2IW1B@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TH2_k127_3940169_2	478741.JAFS01000002_gene955	4.101e-49	186.0	COG1033@1|root,COG1033@2|Bacteria,46Z86@74201|Verrucomicrobia,37G0Z@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
TH2_k127_3940169_1	497964.CfE428DRAFT_4430	7.448e-116	389.0	COG0016@1|root,COG0016@2|Bacteria,46S6R@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
TH2_k127_3940169_0	234267.Acid_7735	1.742e-230	729.0	COG1032@1|root,COG1032@2|Bacteria,3Y4FB@57723|Acidobacteria	57723|Acidobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
TH2_k127_3940169_3	1123508.JH636443_gene4818	1.227e-06	59.0	COG1633@1|root,COG1633@2|Bacteria,2J29M@203682|Planctomycetes	203682|Planctomycetes	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3946276_14	1340493.JNIF01000003_gene2631	1.728e-69	250.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	rfbU	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
TH2_k127_3946276_65	574376.BAMA_00860	9.158e-08	59.0	COG1544@1|root,COG1544@2|Bacteria,1V1D5@1239|Firmicutes,4HFX9@91061|Bacilli,1ZFW8@1386|Bacillus	91061|Bacilli	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
TH2_k127_3946276_64	1303518.CCALI_02010	8.931e-08	60.0	COG5660@1|root,COG5660@2|Bacteria	2|Bacteria	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
TH2_k127_3946276_38	1396141.BATP01000003_gene4949	2.285e-40	156.0	COG1595@1|root,COG1595@2|Bacteria,46SZG@74201|Verrucomicrobia,2IUFS@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TH2_k127_3946276_17	497964.CfE428DRAFT_2511	1.301e-63	222.0	COG0417@1|root,COG0417@2|Bacteria,46SS2@74201|Verrucomicrobia	74201|Verrucomicrobia	L	RNase_H superfamily	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	RNase_H_2
TH2_k127_3946276_10	383372.Rcas_2891	2.983e-92	314.0	COG3804@1|root,COG3804@2|Bacteria,2G7MJ@200795|Chloroflexi	200795|Chloroflexi	C	Dihydrodipicolinate reductase, N-terminus	-	-	1.4.1.12,1.4.1.26	ko:K21672	ko00310,ko00330,ko00472,map00310,map00330,map00472	-	R02825,R04200,R04201,R04687,R04688	RC00249,RC00790	ko00000,ko00001,ko01000	-	-	-	DapB_N
TH2_k127_3946276_1	1121918.ARWE01000001_gene2682	0.0	1691.0	COG0210@1|root,COG0514@1|root,COG0210@2|Bacteria,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,42MV3@68525|delta/epsilon subdivisions,2WJZB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	ATP-dependent DNA helicase RecQ	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,UvrD-helicase,UvrD_C
TH2_k127_3946276_45	383372.Rcas_2370	9.814e-29	129.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	ogl	-	4.2.2.6	ko:K01730,ko:K03641	ko00040,map00040	-	R04382	RC02124,RC02427	ko00000,ko00001,ko01000,ko02000	2.C.1.2	-	-	PD40,Pectate_lyase22
TH2_k127_3946276_22	1120999.JONM01000003_gene2723	2.122e-58	215.0	COG1510@1|root,COG1510@2|Bacteria,1RA49@1224|Proteobacteria,2VQNT@28216|Betaproteobacteria,2KQ5T@206351|Neisseriales	206351|Neisseriales	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
TH2_k127_3946276_27	314230.DSM3645_07370	1.495e-54	207.0	295WE@1|root,2ZT7B@2|Bacteria,2J2RS@203682|Planctomycetes	203682|Planctomycetes	S	Membrane bound O-acyl transferase family	-	-	-	-	-	-	-	-	-	-	-	-	MBOAT_2
TH2_k127_3946276_50	1396418.BATQ01000007_gene1408	2.479e-23	108.0	2DS4P@1|root,33EH8@2|Bacteria,46XKS@74201|Verrucomicrobia,2IW5C@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3946276_47	634497.HAH_3073	4.38e-24	117.0	arCOG11971@1|root,arCOG11971@2157|Archaea,2XWIZ@28890|Euryarchaeota,23VA2@183963|Halobacteria	183963|Halobacteria	S	YndJ-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YndJ
TH2_k127_3946276_60	575540.Isop_3458	3.962e-10	66.0	COG3011@1|root,COG3011@2|Bacteria,2IYVQ@203682|Planctomycetes	203682|Planctomycetes	S	Vitamin K-dependent gamma-carboxylase	-	-	-	-	-	-	-	-	-	-	-	-	DUF393,VKG_Carbox
TH2_k127_3946276_4	382464.ABSI01000011_gene2689	1.262e-205	644.0	COG0050@1|root,COG0050@2|Bacteria,46SFG@74201|Verrucomicrobia,2ITQE@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
TH2_k127_3946276_56	1235796.C815_01203	2.388e-15	77.0	COG0267@1|root,COG0267@2|Bacteria,1VEJ4@1239|Firmicutes	1239|Firmicutes	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
TH2_k127_3946276_67	207954.MED92_04552	2.343e-06	51.0	COG0690@1|root,COG0690@2|Bacteria,1RDI9@1224|Proteobacteria,1S3PA@1236|Gammaproteobacteria,1XKF5@135619|Oceanospirillales	135619|Oceanospirillales	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
TH2_k127_3946276_66	278957.ABEA03000094_gene4758	1.554e-06	52.0	COG0690@1|root,COG0690@2|Bacteria,46WU6@74201|Verrucomicrobia,3K8FP@414999|Opitutae	414999|Opitutae	U	Belongs to the SecE SEC61-gamma family	-	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
TH2_k127_3946276_15	1396141.BATP01000023_gene539	1.584e-68	239.0	COG0250@1|root,COG0250@2|Bacteria,46SR6@74201|Verrucomicrobia,2IU6S@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	In Spt5p, this domain may confer affinity for Spt4p. It possesses a RNP-like fold.	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
TH2_k127_3946276_21	1156937.MFUM_210036	1.384e-59	211.0	COG0080@1|root,COG0080@2|Bacteria,46SPZ@74201|Verrucomicrobia,37GN5@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
TH2_k127_3946276_12	497964.CfE428DRAFT_5605	1.419e-84	287.0	COG0081@1|root,COG0081@2|Bacteria,46S7K@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
TH2_k127_3946276_42	1396141.BATP01000023_gene536	1.907e-35	142.0	COG0244@1|root,COG0244@2|Bacteria,46T4Q@74201|Verrucomicrobia,2IUF1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
TH2_k127_3946276_34	991905.SL003B_1729	1.47e-47	174.0	COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,2U9FX@28211|Alphaproteobacteria,4BQAY@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
TH2_k127_3946276_2	478741.JAFS01000001_gene1247	0.0	1664.0	COG0085@1|root,COG0085@2|Bacteria,46S8Q@74201|Verrucomicrobia,37FZ1@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
TH2_k127_3946276_0	497964.CfE428DRAFT_5595	0.0	2064.0	COG0086@1|root,COG0086@2|Bacteria,46S79@74201|Verrucomicrobia	74201|Verrucomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
TH2_k127_3946276_16	497964.CfE428DRAFT_0482	2.78e-64	222.0	COG0048@1|root,COG0048@2|Bacteria,46SQR@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
TH2_k127_3946276_24	313628.LNTAR_19677	3.132e-57	203.0	COG0049@1|root,COG0049@2|Bacteria	2|Bacteria	J	rRNA binding	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016020,GO:0016043,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
TH2_k127_3946276_3	243231.GSU2860	1.182e-301	940.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2WIM7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
TH2_k127_3946276_36	497964.CfE428DRAFT_0485	1.986e-44	171.0	COG0051@1|root,COG0051@2|Bacteria,46SVV@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
TH2_k127_3946276_25	1123399.AQVE01000003_gene2044	3.06e-56	203.0	COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,1RMK9@1236|Gammaproteobacteria,4606F@72273|Thiotrichales	72273|Thiotrichales	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
TH2_k127_3946276_32	497964.CfE428DRAFT_0487	9.656e-50	184.0	COG0088@1|root,COG0088@2|Bacteria,46SWJ@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
TH2_k127_3946276_53	240016.ABIZ01000001_gene4077	3.806e-19	91.0	COG0089@1|root,COG0089@2|Bacteria,46WBX@74201|Verrucomicrobia,2IUPY@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
TH2_k127_3946276_8	459349.CLOAM1137	1.935e-104	346.0	COG0090@1|root,COG0090@2|Bacteria,2NNR3@2323|unclassified Bacteria	2|Bacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
TH2_k127_3946276_37	1156937.MFUM_870039	1.68e-41	153.0	COG0185@1|root,COG0185@2|Bacteria,46T4G@74201|Verrucomicrobia,37GV3@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
TH2_k127_3946276_57	497964.CfE428DRAFT_0491	1.053e-13	80.0	2FI21@1|root,349UX@2|Bacteria,46W3I@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3946276_46	497964.CfE428DRAFT_0492	1.775e-28	118.0	COG0091@1|root,COG0091@2|Bacteria,46T5F@74201|Verrucomicrobia	74201|Verrucomicrobia	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
TH2_k127_3946276_11	868595.Desca_0218	1.917e-85	288.0	COG0092@1|root,COG0092@2|Bacteria,1TPCP@1239|Firmicutes,24833@186801|Clostridia,26103@186807|Peptococcaceae	186801|Clostridia	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
TH2_k127_3946276_20	478741.JAFS01000001_gene1586	5.081e-60	209.0	COG0197@1|root,COG0197@2|Bacteria,46ST6@74201|Verrucomicrobia,37GNB@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
TH2_k127_3946276_59	246194.CHY_2301	1.137e-11	71.0	COG0255@1|root,COG0255@2|Bacteria,1VEME@1239|Firmicutes,24QV1@186801|Clostridia,42H7J@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
TH2_k127_3946276_49	1219084.AP014508_gene1604	1.985e-23	103.0	COG0186@1|root,COG0186@2|Bacteria,2GD97@200918|Thermotogae	200918|Thermotogae	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
TH2_k127_3946276_33	1156937.MFUM_870033	4.954e-48	175.0	COG0093@1|root,COG0093@2|Bacteria,46VID@74201|Verrucomicrobia,37GRN@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
TH2_k127_3946276_52	1444309.JAQG01000041_gene3400	4.158e-22	100.0	COG0198@1|root,COG0198@2|Bacteria,1V9ZQ@1239|Firmicutes,4HKH9@91061|Bacilli,26XQC@186822|Paenibacillaceae	91061|Bacilli	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
TH2_k127_3946276_18	1111479.AXAR01000008_gene2346	4.1e-63	222.0	COG0094@1|root,COG0094@2|Bacteria,1TPE0@1239|Firmicutes,4HBAX@91061|Bacilli,278A4@186823|Alicyclobacillaceae	91061|Bacilli	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
TH2_k127_3946276_51	525904.Tter_0728	2.592e-23	100.0	COG0199@1|root,COG0199@2|Bacteria,2NPW7@2323|unclassified Bacteria	2|Bacteria	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
TH2_k127_3946276_39	883066.HMPREF9233_01286	1.245e-39	151.0	COG0096@1|root,COG0096@2|Bacteria,2IHQZ@201174|Actinobacteria,4D5IC@85005|Actinomycetales	201174|Actinobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
TH2_k127_3946276_29	196627.cg0629	4.259e-52	189.0	COG0097@1|root,COG0097@2|Bacteria,2GK35@201174|Actinobacteria,22KFS@1653|Corynebacteriaceae	201174|Actinobacteria	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
TH2_k127_3946276_44	1122921.KB898209_gene2706	5.321e-31	125.0	COG0256@1|root,COG0256@2|Bacteria,1V6DM@1239|Firmicutes,4HIGF@91061|Bacilli,26XMJ@186822|Paenibacillaceae	91061|Bacilli	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
TH2_k127_3946276_19	497964.CfE428DRAFT_0503	1.369e-60	214.0	COG0098@1|root,COG0098@2|Bacteria,46SUR@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
TH2_k127_3946276_35	1396141.BATP01000039_gene1417	3.077e-46	171.0	COG0200@1|root,COG0200@2|Bacteria,46SSX@74201|Verrucomicrobia,2IUE6@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
TH2_k127_3946276_6	497964.CfE428DRAFT_0505	6.389e-151	490.0	COG0201@1|root,COG0201@2|Bacteria,46S86@74201|Verrucomicrobia	74201|Verrucomicrobia	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
TH2_k127_3946276_9	497964.CfE428DRAFT_0506	1.193e-94	319.0	COG0024@1|root,COG0024@2|Bacteria,46SK6@74201|Verrucomicrobia	74201|Verrucomicrobia	J	TIGRFAM methionine aminopeptidase, type I	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
TH2_k127_3946276_58	754252.PFREUD_06030	2.015e-13	70.0	COG0257@1|root,COG0257@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
TH2_k127_3946276_40	2110.MAGa5710	7.366e-39	150.0	COG0099@1|root,COG0099@2|Bacteria,3WTJ4@544448|Tenericutes	544448|Tenericutes	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
TH2_k127_3946276_23	497964.CfE428DRAFT_0509	2.835e-57	204.0	COG0100@1|root,COG0100@2|Bacteria,46STW@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
TH2_k127_3946276_13	497964.CfE428DRAFT_0510	9.563e-75	256.0	COG0522@1|root,COG0522@2|Bacteria,46SNI@74201|Verrucomicrobia	74201|Verrucomicrobia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
TH2_k127_3946276_7	481448.Minf_1439	6.144e-141	457.0	COG0202@1|root,COG0202@2|Bacteria,46S52@74201|Verrucomicrobia,37FXU@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
TH2_k127_3946276_43	1121403.AUCV01000025_gene2272	6.751e-34	135.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,42SBD@68525|delta/epsilon subdivisions,2WP9P@28221|Deltaproteobacteria,2MKCX@213118|Desulfobacterales	28221|Deltaproteobacteria	J	PFAM ribosomal protein L17	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
TH2_k127_3946276_41	1131269.AQVV01000001_gene1327	2.359e-38	157.0	COG1560@1|root,COG1560@2|Bacteria	2|Bacteria	M	Kdo2-lipid A biosynthetic process	htrB	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
TH2_k127_3946276_54	1380387.JADM01000001_gene354	6.289e-18	93.0	COG0500@1|root,COG0500@2|Bacteria,1R4H7@1224|Proteobacteria,1S55S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	sam-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TH2_k127_3946276_26	522306.CAP2UW1_1843	4.911e-55	203.0	COG3642@1|root,COG3642@2|Bacteria	2|Bacteria	T	kinase activity	inaA	-	2.7.11.1,3.6.1.27	ko:K02848,ko:K07178,ko:K19302	ko00540,ko00550,ko01100,ko03008,map00540,map00550,map01100,map03008	M00080	R05627	RC00002	ko00000,ko00001,ko00002,ko01000,ko01001,ko01005,ko01011,ko03009	-	-	-	APH,DUF4032,Kdo
TH2_k127_3946276_55	1027273.GZ77_24065	6.987e-18	94.0	COG0515@1|root,COG0515@2|Bacteria,1RAG3@1224|Proteobacteria,1S4BG@1236|Gammaproteobacteria,1XPEC@135619|Oceanospirillales	135619|Oceanospirillales	KLT	Lipopolysaccharide kinase (Kdo/WaaP) family	-	-	-	-	-	-	-	-	-	-	-	-	Kdo
TH2_k127_3946276_48	313628.LNTAR_01807	1.333e-23	111.0	COG0515@1|root,COG0515@2|Bacteria	313628.LNTAR_01807|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_3946276_62	338963.Pcar_1268	3.031e-09	69.0	COG0515@1|root,COG0515@2|Bacteria,1R47Q@1224|Proteobacteria,42WMT@68525|delta/epsilon subdivisions,2WRXI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KLT	Lipopolysaccharide kinase (Kdo/WaaP) family	-	-	-	-	-	-	-	-	-	-	-	-	Kdo
TH2_k127_3946276_31	1123508.JH636440_gene2742	8.402e-50	190.0	COG1262@1|root,COG4409@1|root,COG1262@2|Bacteria,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2,FGE-sulfatase
TH2_k127_3946276_61	338963.Pcar_1265	2.937e-09	67.0	COG0515@1|root,COG0515@2|Bacteria,1MXX9@1224|Proteobacteria,42WG5@68525|delta/epsilon subdivisions,2X9TH@28221|Deltaproteobacteria,43SZ0@69541|Desulfuromonadales	28221|Deltaproteobacteria	KLT	Lipopolysaccharide kinase (Kdo/WaaP) family	-	-	-	-	-	-	-	-	-	-	-	-	Kdo
TH2_k127_3946276_28	1210884.HG799465_gene11570	2.428e-52	201.0	COG0438@1|root,COG0438@2|Bacteria,2IZ1G@203682|Planctomycetes	203682|Planctomycetes	M	PFAM Glycosyl transferase, group 1	-	-	-	ko:K02844	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT4	-	Glyco_transf_4,Glycos_transf_1
TH2_k127_3946276_63	1141662.OOA_15155	2.344e-08	64.0	COG0500@1|root,COG2226@2|Bacteria,1PN45@1224|Proteobacteria,1RP4K@1236|Gammaproteobacteria,3Z9QN@586|Providencia	1236|Gammaproteobacteria	Q	Putative S-adenosyl-L-methionine-dependent methyltransferase	yafE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TH2_k127_3946276_30	522306.CAP2UW1_1842	2.085e-51	190.0	COG0500@1|root,COG2226@2|Bacteria,1Q73B@1224|Proteobacteria,2W6KU@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TH2_k127_3946276_5	1198232.CYCME_0690	6.874e-198	626.0	COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,1RNN4@1236|Gammaproteobacteria,45ZSA@72273|Thiotrichales	72273|Thiotrichales	O	PFAM Carbamoyltransferase	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
TH2_k127_3946288_0	1340493.JNIF01000003_gene2631	7.453e-64	233.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	rfbU	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
TH2_k127_3955372_5	1121920.AUAU01000002_gene2160	7.303e-24	105.0	COG0731@1|root,COG0731@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TH2_k127_3955372_2	671143.DAMO_3032	1.786e-113	370.0	COG0861@1|root,COG0861@2|Bacteria,2NQFQ@2323|unclassified Bacteria	2|Bacteria	P	Integral membrane protein TerC family	terC	-	-	-	-	-	-	-	-	-	-	-	TerC
TH2_k127_3955372_6	1167006.UWK_01106	5.496e-22	103.0	COG2716@1|root,COG2716@2|Bacteria,1RB6J@1224|Proteobacteria,42RTX@68525|delta/epsilon subdivisions,2WPGC@28221|Deltaproteobacteria,2MJZX@213118|Desulfobacterales	28221|Deltaproteobacteria	E	ACT domain	-	-	-	ko:K03567	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	ACT_6
TH2_k127_3955372_0	207559.Dde_3704	1.947e-175	561.0	COG2848@1|root,COG2848@2|Bacteria,1NAFG@1224|Proteobacteria,42NH7@68525|delta/epsilon subdivisions,2WJJM@28221|Deltaproteobacteria,2M94X@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	UPF0210 protein	-	-	-	ko:K09157	-	-	-	-	ko00000	-	-	-	DUF711
TH2_k127_3955372_3	497964.CfE428DRAFT_0845	6.095e-111	367.0	COG0078@1|root,COG0078@2|Bacteria,46SA5@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
TH2_k127_3955372_1	1121472.AQWN01000001_gene260	7.204e-128	420.0	COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,248C9@186801|Clostridia,2606U@186807|Peptococcaceae	186801|Clostridia	E	PFAM Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TH2_k127_3955372_4	240016.ABIZ01000001_gene1182	5.274e-34	132.0	COG0441@1|root,COG0441@2|Bacteria,46S5A@74201|Verrucomicrobia,2ITM8@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
TH2_k127_3987294_11	1227739.Hsw_1071	5.835e-09	61.0	COG1073@1|root,COG1073@2|Bacteria,4NGG4@976|Bacteroidetes,47PZ3@768503|Cytophagia	976|Bacteroidetes	S	Serine aminopeptidase, S33	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	DLH,Hydrolase_4
TH2_k127_3987294_10	1121396.KB893104_gene1783	1.27e-09	63.0	28J8Y@1|root,2Z943@2|Bacteria,1REXC@1224|Proteobacteria,43DCS@68525|delta/epsilon subdivisions,2X8IT@28221|Deltaproteobacteria,2MK0X@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4338)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4338
TH2_k127_3987294_8	568816.Acin_1628	1.182e-19	94.0	COG1399@1|root,COG1399@2|Bacteria,1VEXU@1239|Firmicutes,4H5EU@909932|Negativicutes	909932|Negativicutes	S	acr, cog1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
TH2_k127_3987294_9	497964.CfE428DRAFT_3891	1.229e-14	75.0	COG0333@1|root,COG0333@2|Bacteria,46TCD@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Ribosomal L32p protein family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
TH2_k127_3987294_5	481448.Minf_1215	4.869e-104	348.0	COG0416@1|root,COG0416@2|Bacteria,46S8C@74201|Verrucomicrobia,37G4Q@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
TH2_k127_3987294_2	497964.CfE428DRAFT_3889	6.865e-131	430.0	COG0332@1|root,COG0332@2|Bacteria,46SE2@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
TH2_k127_3987294_3	234267.Acid_0283	1.06e-120	398.0	COG0399@1|root,COG0399@2|Bacteria,3Y3PT@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
TH2_k127_3987294_4	1396418.BATQ01000149_gene2216	9.476e-116	385.0	COG3174@1|root,COG3174@2|Bacteria,46VTJ@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function (DUF4010)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4010,MgtC
TH2_k127_3987294_1	1116472.MGMO_35c00030	1.317e-134	454.0	COG3291@1|root,COG3291@2|Bacteria,1RGWM@1224|Proteobacteria,1THXR@1236|Gammaproteobacteria,1XFZT@135618|Methylococcales	135618|Methylococcales	S	PKD domain	-	-	-	-	-	-	-	-	-	-	-	-	PKD
TH2_k127_3987294_0	344747.PM8797T_16213	3.702e-256	804.0	COG2217@1|root,COG2217@2|Bacteria,2IXE1@203682|Planctomycetes	203682|Planctomycetes	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	-	-	-	-	-	-	-	-	-	-	E1-E2_ATPase,Hydrolase
TH2_k127_3987294_6	1487923.DP73_03070	2.15e-40	158.0	COG4636@1|root,COG4636@2|Bacteria,1V4N9@1239|Firmicutes,24FY6@186801|Clostridia	186801|Clostridia	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
TH2_k127_3987294_7	6087.XP_002158130.1	2.653e-31	130.0	2ERDI@1|root,2SU79@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4065527_1	1173028.ANKO01000017_gene246	5.459e-74	254.0	COG0309@1|root,COG0309@2|Bacteria,1G1Z7@1117|Cyanobacteria,1H82T@1150|Oscillatoriales	1117|Cyanobacteria	O	hydrogenase expression formation protein HypE	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
TH2_k127_4065527_0	518766.Rmar_2595	1.026e-187	591.0	COG0409@1|root,COG0409@2|Bacteria,4NIM8@976|Bacteroidetes	976|Bacteroidetes	O	TIGRFAM hydrogenase expression formation protein HypD	-	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
TH2_k127_4065527_2	314230.DSM3645_19378	6.866e-62	220.0	COG0731@1|root,COG0731@2|Bacteria,2IXA2@203682|Planctomycetes	203682|Planctomycetes	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TH2_k127_4101425_11	323848.Nmul_D2821	8.969e-07	51.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VHER@28216|Betaproteobacteria,372VZ@32003|Nitrosomonadales	28216|Betaproteobacteria	L	PFAM Integrase, catalytic	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve_3
TH2_k127_4101425_10	313628.LNTAR_10126	6.124e-07	62.0	COG2963@1|root,COG2963@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_28,HTH_Tnp_1
TH2_k127_4101425_4	314230.DSM3645_20132	4.672e-119	394.0	COG3635@1|root,COG3635@2|Bacteria,2IY5S@203682|Planctomycetes	203682|Planctomycetes	G	phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
TH2_k127_4101425_6	1157490.EL26_00495	1.445e-49	190.0	COG0598@1|root,COG0598@2|Bacteria,1TPSV@1239|Firmicutes,4HCQF@91061|Bacilli,279MV@186823|Alicyclobacillaceae	91061|Bacilli	P	CorA-like Mg2+ transporter protein	-	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
TH2_k127_4101425_3	497964.CfE428DRAFT_6711	1.246e-125	415.0	COG5000@1|root,COG5000@2|Bacteria,46S9Q@74201|Verrucomicrobia	74201|Verrucomicrobia	T	PFAM ATP-binding region ATPase domain protein	ntrB	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8
TH2_k127_4101425_1	1156937.MFUM_920003	3.308e-153	498.0	COG2204@1|root,COG2204@2|Bacteria,46SFE@74201|Verrucomicrobia,37GCZ@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH2_k127_4101425_8	497964.CfE428DRAFT_6335	9.622e-17	89.0	COG0319@1|root,COG0319@2|Bacteria,46WBN@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
TH2_k127_4101425_5	497964.CfE428DRAFT_6337	5.599e-110	366.0	COG1702@1|root,COG1702@2|Bacteria,46S7S@74201|Verrucomicrobia	74201|Verrucomicrobia	T	PhoH-like protein	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
TH2_k127_4101425_9	1191523.MROS_2296	6.32e-15	83.0	COG1652@1|root,COG1652@2|Bacteria	2|Bacteria	S	positive regulation of growth rate	-	-	-	-	-	-	-	-	-	-	-	-	DUF4398,LysM,SAM_adeno_trans,Y_phosphatase3
TH2_k127_4101425_12	1210884.HG799464_gene10959	4.603e-06	53.0	2CJZ9@1|root,33BD7@2|Bacteria,2J4A3@203682|Planctomycetes	1210884.HG799464_gene10959|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4101425_0	1156937.MFUM_290035	5.217e-181	582.0	COG0119@1|root,COG0119@2|Bacteria,46TQ5@74201|Verrucomicrobia,37G4P@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
TH2_k127_4101425_2	1396418.BATQ01000019_gene5009	1.129e-147	478.0	COG0019@1|root,COG0019@2|Bacteria,46SC5@74201|Verrucomicrobia,2ITWM@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	-	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
TH2_k127_4101425_7	497964.CfE428DRAFT_5124	5.315e-25	109.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,LytTR,PAS,PAS_3,PAS_9,Response_reg,dCache_1
TH2_k127_4214807_4	481448.Minf_0157	3.871e-47	178.0	COG0187@1|root,COG0187@2|Bacteria,46SDH@74201|Verrucomicrobia,37GC3@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
TH2_k127_4214807_5	69014.TK1127	7.464e-10	67.0	COG1895@1|root,arCOG02123@2157|Archaea,2Y05T@28890|Euryarchaeota,245HY@183968|Thermococci	183968|Thermococci	S	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
TH2_k127_4214807_0	945713.IALB_0006	6.704e-311	978.0	COG0188@1|root,COG0188@2|Bacteria	2|Bacteria	L	DNA topoisomerase II activity	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
TH2_k127_4214807_3	497964.CfE428DRAFT_2243	1.195e-141	463.0	COG2805@1|root,COG2805@2|Bacteria,46UF2@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
TH2_k127_4214807_2	349741.Amuc_0166	1.991e-156	500.0	COG2805@1|root,COG2805@2|Bacteria,46SY2@74201|Verrucomicrobia,2ITP5@203494|Verrucomicrobiae	203494|Verrucomicrobiae	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
TH2_k127_4214807_1	335543.Sfum_1909	5.612e-234	748.0	COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,42M8J@68525|delta/epsilon subdivisions,2WJD6@28221|Deltaproteobacteria,2MQAU@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
TH2_k127_4214807_6	1408303.JNJJ01000106_gene14	3.939e-09	58.0	COG0691@1|root,COG0691@2|Bacteria,1V3IJ@1239|Firmicutes,4HGZX@91061|Bacilli,1ZFJ0@1386|Bacillus	91061|Bacilli	O	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070930,GO:0071704,GO:1901564	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
TH2_k127_4230714_1	481448.Minf_1937	5.069e-22	97.0	COG1862@1|root,COG1862@2|Bacteria,46T88@74201|Verrucomicrobia,37GU3@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	U	Preprotein translocase subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
TH2_k127_4230714_0	452637.Oter_3464	1.545e-171	569.0	COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,46SA4@74201|Verrucomicrobia,3K770@414999|Opitutae	414999|Opitutae	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4	-	-	SecD_SecF,Sec_GG
TH2_k127_4238382_11	481448.Minf_0272	4.313e-32	126.0	2CK2Q@1|root,30XDX@2|Bacteria,46X4H@74201|Verrucomicrobia,37HA6@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4238382_9	481448.Minf_2121	7.278e-33	136.0	2AG58@1|root,3169Z@2|Bacteria,46WMP@74201|Verrucomicrobia,37GPD@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4238382_4	269799.Gmet_3404	1.145e-74	259.0	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,42NJJ@68525|delta/epsilon subdivisions,2WJGI@28221|Deltaproteobacteria,43SZG@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)	pdxA	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
TH2_k127_4238382_6	481448.Minf_0292	5.892e-67	241.0	COG0760@1|root,COG0760@2|Bacteria,46SU4@74201|Verrucomicrobia,37G1D@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
TH2_k127_4238382_5	1191523.MROS_1656	7.052e-70	250.0	COG0859@1|root,COG0859@2|Bacteria	2|Bacteria	M	ADP-heptose-lipopolysaccharide heptosyltransferase activity	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
TH2_k127_4238382_8	1007103.AFHW01000025_gene308	5.194e-54	202.0	COG1089@1|root,COG1089@2|Bacteria,1UJFF@1239|Firmicutes,4HF5Y@91061|Bacilli,275YJ@186822|Paenibacillaceae	91061|Bacilli	M	Polysaccharide biosynthesis protein	-	-	1.1.1.281	ko:K15856	ko00051,ko00520,map00051,map00520	-	R03397,R03399	RC00182	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
TH2_k127_4238382_12	379066.GAU_1038	1.35e-05	59.0	COG5617@1|root,COG5617@2|Bacteria,1ZUMG@142182|Gemmatimonadetes	2|Bacteria	S	Bacterial membrane protein YfhO	-	-	-	-	-	-	-	-	-	-	-	-	PTPS_related,YfhO
TH2_k127_4238382_10	1121920.AUAU01000006_gene239	1.435e-32	130.0	COG3824@1|root,COG3824@2|Bacteria,3Y8W9@57723|Acidobacteria	57723|Acidobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
TH2_k127_4238382_7	667014.Thein_1323	1.141e-64	230.0	COG1355@1|root,COG1355@2|Bacteria,2GHI9@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
TH2_k127_4238382_1	515635.Dtur_1704	9.501e-117	396.0	COG4608@1|root,COG4608@2|Bacteria	2|Bacteria	P	Belongs to the ABC transporter superfamily	gsiA_8	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
TH2_k127_4238382_2	1304880.JAGB01000002_gene2307	7.805e-113	373.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TH2_k127_4238382_0	515635.Dtur_1706	5.299e-124	407.0	COG1173@1|root,COG1173@2|Bacteria	2|Bacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	oppC	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TH2_k127_4238382_3	697281.Mahau_1199	9.775e-103	344.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,42GB7@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	appB	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TH2_k127_429320_1	382464.ABSI01000010_gene3372	5.7e-23	107.0	COG0457@1|root,COG4783@1|root,COG0457@2|Bacteria,COG4783@2|Bacteria,46TQ7@74201|Verrucomicrobia,2ITH6@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
TH2_k127_429320_0	1150600.ADIARSV_4022	6.371e-111	381.0	COG5434@1|root,COG5434@2|Bacteria,4NICS@976|Bacteroidetes,1IVWC@117747|Sphingobacteriia	976|Bacteroidetes	G	Pectate lyase superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_28
TH2_k127_4295464_12	448385.sce3058	1.01e-77	270.0	COG1175@1|root,COG1175@2|Bacteria,1MVAP@1224|Proteobacteria,42MJN@68525|delta/epsilon subdivisions,2WITF@28221|Deltaproteobacteria,2Z0Q0@29|Myxococcales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025,ko:K05814,ko:K17316	ko02010,map02010	M00198,M00207,M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.24,3.A.1.1.3,3.A.1.1.30	-	-	BPD_transp_1
TH2_k127_4295464_14	1385511.N783_18660	1.381e-69	254.0	COG0395@1|root,COG0395@2|Bacteria,1TRCP@1239|Firmicutes,4HBKE@91061|Bacilli,2YBVV@289201|Pontibacillus	91061|Bacilli	U	Sugar ABC transporter permease	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TH2_k127_4295464_4	497964.CfE428DRAFT_5386	6.322e-123	402.0	COG2876@1|root,COG2876@2|Bacteria,46SUJ@74201|Verrucomicrobia	74201|Verrucomicrobia	E	PFAM DAHP synthetase I KDSA	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
TH2_k127_4295464_10	357808.RoseRS_1877	7.14e-88	306.0	COG0464@1|root,COG0464@2|Bacteria,2G642@200795|Chloroflexi,374VH@32061|Chloroflexia	32061|Chloroflexia	O	PFAM AAA ATPase central domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA
TH2_k127_4295464_20	1449335.JQLG01000004_gene2176	5.348e-08	61.0	COG0726@1|root,COG1388@1|root,COG0726@2|Bacteria,COG1388@2|Bacteria,1UZ7Q@1239|Firmicutes,4IPRX@91061|Bacilli,27FRM@186828|Carnobacteriaceae	91061|Bacilli	GM	Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	LysM,Polysacc_deac_1
TH2_k127_4295464_15	1340493.JNIF01000004_gene143	5.394e-69	243.0	COG1845@1|root,COG1845@2|Bacteria,3Y414@57723|Acidobacteria	57723|Acidobacteria	C	PFAM cytochrome c oxidase, subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
TH2_k127_4295464_1	1123242.JH636434_gene3641	2.782e-268	836.0	COG0843@1|root,COG0843@2|Bacteria,2IXCQ@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
TH2_k127_4295464_5	234267.Acid_0497	1.519e-116	383.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,3Y2GR@57723|Acidobacteria	57723|Acidobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C,Cytochrome_CBB3
TH2_k127_4295464_11	886293.Sinac_3660	2.346e-85	296.0	COG1999@1|root,COG1999@2|Bacteria,2IYYD@203682|Planctomycetes	203682|Planctomycetes	S	protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
TH2_k127_4295464_7	1128421.JAGA01000003_gene2874	2.249e-105	355.0	COG4531@1|root,COG4531@2|Bacteria,2NP5Y@2323|unclassified Bacteria	2|Bacteria	P	ABC-type Zn2 transport system, periplasmic component surface adhesin	actF	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4295464_16	234267.Acid_0493	1.861e-50	188.0	COG2010@1|root,COG2010@2|Bacteria,3Y2MN@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
TH2_k127_4295464_13	1128421.JAGA01000003_gene2872	2.921e-71	245.0	COG2010@1|root,COG2010@2|Bacteria,2NPSE@2323|unclassified Bacteria	2|Bacteria	C	Protein of unknown function (DUF3341)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
TH2_k127_4295464_3	1128421.JAGA01000003_gene2871	5.13e-217	681.0	COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria	2|Bacteria	C	Polysulphide reductase, NrfD	nrfD	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	DUF3341,NrfD
TH2_k127_4295464_0	1128421.JAGA01000003_gene2870	0.0	1176.0	COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,2NNV6@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	hmeA	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7,Molydop_binding
TH2_k127_4295464_9	886293.Sinac_3667	2.626e-91	305.0	COG3880@1|root,COG3880@2|Bacteria,2IYYJ@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
TH2_k127_4295464_2	313628.LNTAR_23384	2.077e-247	801.0	COG0013@1|root,COG0013@2|Bacteria	2|Bacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
TH2_k127_4295464_18	497964.CfE428DRAFT_1468	8.128e-15	87.0	2CK49@1|root,2ZE58@2|Bacteria,46WV3@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4295464_17	497964.CfE428DRAFT_1468	1.377e-16	92.0	2CK49@1|root,2ZE58@2|Bacteria,46WV3@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4295464_6	497964.CfE428DRAFT_1691	1.553e-110	365.0	COG0524@1|root,COG0524@2|Bacteria,46U0Y@74201|Verrucomicrobia	74201|Verrucomicrobia	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
TH2_k127_4295464_8	1121403.AUCV01000050_gene2091	8.727e-97	325.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,42N7M@68525|delta/epsilon subdivisions,2WIJ0@28221|Deltaproteobacteria,2MITQ@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
TH2_k127_429745_2	713586.KB900536_gene472	1.324e-16	91.0	COG1988@1|root,COG1988@2|Bacteria,1R5QP@1224|Proteobacteria	1224|Proteobacteria	S	membrane-bound metal-dependent	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
TH2_k127_429745_1	234267.Acid_5566	1.38e-24	114.0	COG0428@1|root,COG0428@2|Bacteria,3Y8C3@57723|Acidobacteria	57723|Acidobacteria	P	transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_429745_0	264732.Moth_1809	9.17e-245	769.0	COG0296@1|root,COG0296@2|Bacteria,1TP4M@1239|Firmicutes,247WH@186801|Clostridia,42FTG@68295|Thermoanaerobacterales	186801|Clostridia	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18,3.2.1.141	ko:K00700,ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110,R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48,DUF3459
TH2_k127_4317106_0	1380390.JIAT01000009_gene1067	2.981e-62	228.0	COG0673@1|root,COG0673@2|Bacteria,2I9W2@201174|Actinobacteria	201174|Actinobacteria	S	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TH2_k127_4317106_1	1210884.HG799462_gene8241	1.126e-57	220.0	COG1520@1|root,COG1520@2|Bacteria,2J1S1@203682|Planctomycetes	203682|Planctomycetes	P	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
TH2_k127_434815_0	240016.ABIZ01000001_gene1887	3.024e-72	255.0	COG1183@1|root,COG1183@2|Bacteria,46SK0@74201|Verrucomicrobia,2ITHZ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
TH2_k127_434815_1	481448.Minf_0015	9.97e-38	147.0	COG0688@1|root,COG0688@2|Bacteria,46VRI@74201|Verrucomicrobia,37GNN@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
TH2_k127_444819_16	1183377.Py04_0637	3.907e-10	72.0	COG0466@1|root,COG1372@1|root,arCOG02160@2157|Archaea,arCOG03158@2157|Archaea,2Y2YB@28890|Euryarchaeota,242YP@183968|Thermococci	183968|Thermococci	O	Belongs to the peptidase S16 family	-	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C,Mg_chelatase
TH2_k127_444819_11	1507.HMPREF0262_02967	2.576e-42	165.0	COG2071@1|root,COG2071@2|Bacteria,1V1KC@1239|Firmicutes,24JCU@186801|Clostridia,36DTE@31979|Clostridiaceae	186801|Clostridia	S	Peptidase C26	ntpR	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
TH2_k127_444819_6	1414720.CBYM010000003_gene388	1.551e-92	316.0	COG0524@1|root,COG0524@2|Bacteria,1V4QY@1239|Firmicutes,24HRA@186801|Clostridia,36S3G@31979|Clostridiaceae	186801|Clostridia	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
TH2_k127_444819_9	65093.PCC7418_2293	2.728e-59	214.0	2CAZH@1|root,2Z7RU@2|Bacteria,1G613@1117|Cyanobacteria	1117|Cyanobacteria	C	TIGRFAM succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family	-	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
TH2_k127_444819_0	497964.CfE428DRAFT_3990	5e-323	997.0	COG1053@1|root,COG1053@2|Bacteria,46S7D@74201|Verrucomicrobia	74201|Verrucomicrobia	C	TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TH2_k127_444819_3	382464.ABSI01000012_gene2122	1.097e-115	378.0	COG0479@1|root,COG0479@2|Bacteria,46S82@74201|Verrucomicrobia,2ITQJ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
TH2_k127_444819_7	481448.Minf_1734	2.165e-71	251.0	COG0842@1|root,COG0842@2|Bacteria,46YUC@74201|Verrucomicrobia,37FVS@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TH2_k127_444819_8	886293.Sinac_6891	1.003e-63	241.0	COG1999@1|root,COG2322@1|root,COG1999@2|Bacteria,COG2322@2|Bacteria,2IZH2@203682|Planctomycetes	203682|Planctomycetes	S	SCO1/SenC	-	-	-	ko:K07152,ko:K08976	-	-	-	-	ko00000,ko03029	-	-	-	DUF420,SCO1-SenC
TH2_k127_444819_14	237368.SCABRO_00345	1.934e-24	112.0	COG3794@1|root,COG3794@2|Bacteria,2J06V@203682|Planctomycetes	203682|Planctomycetes	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	fn3_3
TH2_k127_444819_5	1396141.BATP01000039_gene1255	7.767e-107	357.0	COG1600@1|root,COG1600@2|Bacteria,46SDV@74201|Verrucomicrobia,2ITS7@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Domain of unknown function (DUF1730)	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
TH2_k127_444819_4	880073.Calab_2195	1.656e-109	372.0	COG1271@1|root,COG2010@1|root,COG1271@2|Bacteria,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I,Cytochrome_CBB3
TH2_k127_444819_15	883.DvMF_2530	3.024e-14	85.0	COG1271@1|root,COG1271@2|Bacteria,1QXQF@1224|Proteobacteria,42NKJ@68525|delta/epsilon subdivisions,2WKHM@28221|Deltaproteobacteria,2M95S@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	oxidase subunit	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	-
TH2_k127_444819_1	479434.Sthe_1093	7.207e-296	920.0	COG0366@1|root,COG0366@2|Bacteria,2G89J@200795|Chloroflexi,27XYW@189775|Thermomicrobia	189775|Thermomicrobia	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
TH2_k127_444819_2	1123242.JH636434_gene4307	3.582e-195	619.0	COG1032@1|root,COG1032@2|Bacteria,2J1W3@203682|Planctomycetes	203682|Planctomycetes	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4080,Radical_SAM
TH2_k127_444819_10	497964.CfE428DRAFT_0236	1.003e-54	203.0	COG0030@1|root,COG1443@1|root,COG0030@2|Bacteria,COG1443@2|Bacteria,46T1S@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	NUDIX,RrnaAD
TH2_k127_444819_18	555793.WSK_3363	3.284e-05	54.0	COG3678@1|root,COG3678@2|Bacteria,1N273@1224|Proteobacteria,2UAXT@28211|Alphaproteobacteria,2K5E6@204457|Sphingomonadales	204457|Sphingomonadales	NPTU	Heavy metal resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	Metal_resist
TH2_k127_444819_12	1396141.BATP01000032_gene4393	3.959e-33	138.0	COG1595@1|root,COG1595@2|Bacteria,46VAA@74201|Verrucomicrobia,2IUMN@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TH2_k127_444819_17	478741.JAFS01000002_gene410	7.233e-08	58.0	2CK2Q@1|root,329IJ@2|Bacteria,46ZCM@74201|Verrucomicrobia,37GU0@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4459967_10	886293.Sinac_6850	6.734e-25	107.0	COG1595@1|root,COG1595@2|Bacteria,2J0KR@203682|Planctomycetes	203682|Planctomycetes	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TH2_k127_4459967_15	266117.Rxyl_0026	4.097e-06	58.0	COG1716@1|root,COG1716@2|Bacteria,2GNU2@201174|Actinobacteria,4CQB6@84995|Rubrobacteria	84995|Rubrobacteria	T	Protein of unknown function (DUF2662)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3662,FHA
TH2_k127_4459967_9	497964.CfE428DRAFT_0075	1.109e-68	253.0	COG1262@1|root,COG2204@1|root,COG1262@2|Bacteria,COG2204@2|Bacteria,46TPR@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
TH2_k127_4459967_4	404589.Anae109_1656	1.421e-130	424.0	COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,42NHN@68525|delta/epsilon subdivisions	1224|Proteobacteria	C	Cytochrome d ubiquinol oxidase, subunit II	cydB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	iECABU_c1320.ECABU_c10120,iLF82_1304.LF82_0101,iNRG857_1313.NRG857_04455,iPC815.YPO1118,ic_1306.c1120	Cyt_bd_oxida_II
TH2_k127_4459967_1	756272.Plabr_1583	5.831e-175	560.0	COG1271@1|root,COG1271@2|Bacteria,2IXYC@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome bd-type quinol oxidase subunit 1	-	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
TH2_k127_4459967_5	497964.CfE428DRAFT_5395	3.935e-123	404.0	COG0136@1|root,COG0136@2|Bacteria,46S74@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
TH2_k127_4459967_13	313628.LNTAR_04711	2.067e-11	66.0	2EIJD@1|root,33CAP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4459967_8	240016.ABIZ01000001_gene4597	6.453e-69	239.0	COG1403@1|root,COG1403@2|Bacteria,46UDR@74201|Verrucomicrobia,2IUK8@203494|Verrucomicrobiae	203494|Verrucomicrobiae	V	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	HNH_4
TH2_k127_4459967_6	314230.DSM3645_14690	7.572e-107	370.0	COG0501@1|root,COG0501@2|Bacteria	2|Bacteria	O	metalloendopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
TH2_k127_4459967_0	497964.CfE428DRAFT_5974	0.0	1750.0	COG0419@1|root,COG1112@1|root,COG3831@1|root,COG0419@2|Bacteria,COG1112@2|Bacteria,COG3831@2|Bacteria	2|Bacteria	L	Superfamily I DNA and RNA helicases and helicase subunits	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12,DUF4011,Tubulin_2,WGR
TH2_k127_4459967_2	460265.Mnod_4254	9.565e-155	497.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,2U2PN@28211|Alphaproteobacteria,1JWZ2@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	tRNA-splicing ligase RtcB	-	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
TH2_k127_4459967_12	82654.Pse7367_3904	1.703e-12	69.0	2E9VI@1|root,3341D@2|Bacteria,1GRB3@1117|Cyanobacteria	1117|Cyanobacteria	S	Addiction module component, TIGR02574 family	-	-	-	-	-	-	-	-	-	-	-	-	Unstab_antitox
TH2_k127_4459967_11	1396141.BATP01000039_gene1320	1.466e-14	76.0	COG3668@1|root,COG3668@2|Bacteria,46WJ8@74201|Verrucomicrobia	74201|Verrucomicrobia	S	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
TH2_k127_4459967_3	497964.CfE428DRAFT_3808	6.545e-133	441.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	mtsE	-	-	-	-	-	-	-	-	-	-	-	TROVE,VWA_2
TH2_k127_4459967_7	497964.CfE428DRAFT_3816	6.552e-80	275.0	2A8GS@1|root,30XIR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4461193_35	240016.ABIZ01000001_gene5517	1.74e-20	93.0	COG1861@1|root,COG1861@2|Bacteria,46UVT@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
TH2_k127_4461193_18	452637.Oter_3749	1.328e-73	258.0	COG3267@1|root,COG3267@2|Bacteria,46SXM@74201|Verrucomicrobia,3K91Q@414999|Opitutae	414999|Opitutae	U	Pfam:Arch_ATPase	-	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22
TH2_k127_4461193_39	720554.Clocl_2873	1.29e-13	75.0	COG0695@1|root,COG0695@2|Bacteria,1VI6J@1239|Firmicutes,24QNT@186801|Clostridia,3WQ6S@541000|Ruminococcaceae	186801|Clostridia	O	Glutathione S-transferase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
TH2_k127_4461193_6	671143.DAMO_3100	6.03e-171	551.0	COG0111@1|root,COG0111@2|Bacteria,2NNZW@2323|unclassified Bacteria	2|Bacteria	EH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
TH2_k127_4461193_7	497964.CfE428DRAFT_3903	1.621e-167	544.0	COG1640@1|root,COG1640@2|Bacteria,46SX0@74201|Verrucomicrobia	74201|Verrucomicrobia	G	PFAM glycoside hydrolase family 77	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
TH2_k127_4461193_44	1380354.JIAN01000005_gene2268	7.044e-08	56.0	COG0861@1|root,COG0861@2|Bacteria	2|Bacteria	P	Integral membrane protein TerC family	-	-	-	-	-	-	-	-	-	-	-	-	PGPGW
TH2_k127_4461193_21	330214.NIDE3403	5.778e-59	216.0	COG2095@1|root,COG2095@2|Bacteria,3J0UZ@40117|Nitrospirae	40117|Nitrospirae	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
TH2_k127_4461193_15	1168034.FH5T_08055	1.19e-81	287.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,SLH,SprB,VCBS
TH2_k127_4461193_40	382464.ABSI01000006_gene849	7.249e-11	67.0	COG1595@1|root,COG1595@2|Bacteria,46VJX@74201|Verrucomicrobia,2IUEG@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TH2_k127_4461193_43	595460.RRSWK_05050	6.724e-08	56.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Pur_ac_phosph_N
TH2_k127_4461193_28	290315.Clim_0579	2.213e-36	160.0	COG3509@1|root,COG3509@2|Bacteria	2|Bacteria	Q	xylan catabolic process	-	-	-	ko:K03932	-	-	-	-	ko00000	-	CE1	-	Abhydrolase_2,Esterase_phd
TH2_k127_4461193_36	395965.Msil_3566	3.522e-20	107.0	COG3509@1|root,COG3509@2|Bacteria,1N6M6@1224|Proteobacteria,2U39G@28211|Alphaproteobacteria,3NAAP@45404|Beijerinckiaceae	28211|Alphaproteobacteria	Q	Esterase PHB depolymerase	-	-	-	ko:K03932	-	-	-	-	ko00000	-	CE1	-	Abhydrolase_2,Esterase_phd
TH2_k127_4461193_42	502025.Hoch_3931	4.347e-08	67.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,42Q8W@68525|delta/epsilon subdivisions,2WJVN@28221|Deltaproteobacteria,2YUCN@29|Myxococcales	28221|Deltaproteobacteria	EU	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9,Peptidase_S9_N
TH2_k127_4461193_46	251221.35214804	0.000393	48.0	COG4188@1|root,COG4188@2|Bacteria,1GD7B@1117|Cyanobacteria	1117|Cyanobacteria	S	Platelet-activating factor acetylhydrolase, isoform II	-	-	-	-	-	-	-	-	-	-	-	-	PAF-AH_p_II
TH2_k127_4461193_47	767817.Desgi_1747	0.0006739	50.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1,Y2_Tnp,Zn_Tnp_IS91
TH2_k127_4461193_37	177437.HRM2_06600	1.207e-17	86.0	2DQN1@1|root,337Q5@2|Bacteria	2|Bacteria	S	Transposase zinc-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Zn_Tnp_IS91
TH2_k127_4461193_45	237368.SCABRO_03851	5.968e-06	55.0	COG2165@1|root,COG2165@2|Bacteria,2J0Q6@203682|Planctomycetes	203682|Planctomycetes	U	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
TH2_k127_4461193_0	344747.PM8797T_19697	0.0	1622.0	COG0714@1|root,COG0714@2|Bacteria	2|Bacteria	KLT	Associated with various cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5,DUF3686
TH2_k127_4461193_48	596151.DesfrDRAFT_0768	0.0009972	48.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42P5K@68525|delta/epsilon subdivisions,2WIKI@28221|Deltaproteobacteria,2M8G7@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH2_k127_4461193_8	497964.CfE428DRAFT_6471	8.125e-158	507.0	COG0508@1|root,COG0508@2|Bacteria,46UHU@74201|Verrucomicrobia	74201|Verrucomicrobia	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TH2_k127_4461193_5	497964.CfE428DRAFT_6472	3.749e-171	541.0	COG0022@1|root,COG0022@2|Bacteria,46UID@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
TH2_k127_4461193_10	497964.CfE428DRAFT_6473	7.253e-136	445.0	COG1071@1|root,COG1071@2|Bacteria,46UAY@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Dehydrogenase E1 component	-	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
TH2_k127_4461193_16	521098.Aaci_2606	7.666e-81	278.0	COG0414@1|root,COG0414@2|Bacteria,1TP7A@1239|Firmicutes,4HAIQ@91061|Bacilli,2784W@186823|Alicyclobacillaceae	91061|Bacilli	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
TH2_k127_4461193_2	478741.JAFS01000001_gene1100	1.596e-207	658.0	COG0029@1|root,COG0029@2|Bacteria,46SHQ@74201|Verrucomicrobia,37FXA@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TH2_k127_4461193_9	387093.SUN_1122	2.053e-144	478.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,42PW9@68525|delta/epsilon subdivisions,2YN4S@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	P	Na Pi-cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans
TH2_k127_4461193_23	1123242.JH636434_gene4639	1.472e-50	184.0	COG0720@1|root,COG0720@2|Bacteria,2J000@203682|Planctomycetes	203682|Planctomycetes	H	COG0720 6-pyruvoyl-tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
TH2_k127_4461193_33	319236.JCM19294_2353	1.959e-21	106.0	COG3170@1|root,COG3170@2|Bacteria,4NF47@976|Bacteroidetes,1HXT1@117743|Flavobacteriia,3HJPP@363408|Nonlabens	976|Bacteroidetes	NU	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
TH2_k127_4461193_11	497964.CfE428DRAFT_4472	3.749e-128	419.0	COG1899@1|root,COG1899@2|Bacteria	2|Bacteria	O	peptidyl-lysine modification to peptidyl-hypusine	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4461193_14	1403819.BATR01000051_gene1546	2.078e-89	305.0	COG2870@1|root,COG2870@2|Bacteria,46T1J@74201|Verrucomicrobia,2IVXQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	pfkB family carbohydrate kinase	-	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	PfkB
TH2_k127_4461193_25	1128421.JAGA01000003_gene2807	5.162e-45	168.0	COG3411@1|root,COG3411@2|Bacteria	2|Bacteria	C	Ferredoxin	-	-	6.6.1.2	ko:K02230	ko00860,ko01100,map00860,map01100	-	R05227	RC02000	ko00000,ko00001,ko01000	-	-	-	-
TH2_k127_4461193_17	671143.DAMO_2922	4.543e-78	284.0	COG1562@1|root,COG1562@2|Bacteria,2NQ18@2323|unclassified Bacteria	2|Bacteria	I	Squalene/phytoene synthase	crtB	GO:0003674,GO:0003824,GO:0004337,GO:0004659,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016108,GO:0016109,GO:0016114,GO:0016116,GO:0016117,GO:0016740,GO:0016765,GO:0016767,GO:0042440,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046148,GO:0071704,GO:1901576	2.5.1.21,2.5.1.32,2.5.1.96,2.5.1.99	ko:K00801,ko:K02291,ko:K10208	ko00100,ko00906,ko00909,ko01062,ko01100,ko01110,ko01130,map00100,map00906,map00909,map01062,map01100,map01110,map01130	M00097	R00702,R02065,R02872,R04218,R06223,R07270,R07652,R09793,R10177	RC00362,RC00796,RC01101,RC02839,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
TH2_k127_4461193_27	1125863.JAFN01000001_gene114	1.4e-38	155.0	COG0664@1|root,COG0664@2|Bacteria,1MZZD@1224|Proteobacteria,42QUX@68525|delta/epsilon subdivisions,2WMWV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	PFAM Cyclic nucleotide-binding	fnr-1	-	-	ko:K01420,ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
TH2_k127_4461193_20	269799.Gmet_2567	1.259e-66	236.0	COG1043@1|root,COG1043@2|Bacteria,1R8TC@1224|Proteobacteria,42MH4@68525|delta/epsilon subdivisions,2WJYN@28221|Deltaproteobacteria,43SC1@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA-2	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iAF987.Gmet_2567	Acetyltransf_11,Hexapep
TH2_k127_4461193_30	497964.CfE428DRAFT_4583	1.354e-27	120.0	COG1381@1|root,COG1381@2|Bacteria,46VUW@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
TH2_k127_4461193_26	1449126.JQKL01000073_gene3044	3.535e-42	163.0	COG2928@1|root,COG2928@2|Bacteria,1V6FM@1239|Firmicutes,24JQ1@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
TH2_k127_4461193_19	665571.STHERM_c13810	8.776e-70	248.0	COG2172@1|root,COG2524@1|root,COG2172@2|Bacteria,COG2524@2|Bacteria,2J63A@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HATPase_c
TH2_k127_4461193_34	1122931.AUAE01000003_gene273	5.088e-21	97.0	COG4109@1|root,COG4109@2|Bacteria,4NTA0@976|Bacteroidetes,2FTZ6@200643|Bacteroidia,22YI5@171551|Porphyromonadaceae	976|Bacteroidetes	K	DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
TH2_k127_4461193_24	65393.PCC7424_4167	2.395e-45	173.0	COG1905@1|root,COG1905@2|Bacteria,1G54V@1117|Cyanobacteria,3KHR4@43988|Cyanothece	1117|Cyanobacteria	C	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit	hoxE	-	1.6.5.3	ko:K05586	ko00190,ko01100,map00190,map01100	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	2Fe-2S_thioredx
TH2_k127_4461193_29	742733.HMPREF9469_02738	3.238e-31	134.0	COG4191@1|root,COG4191@2|Bacteria,1V6MN@1239|Firmicutes,24JDQ@186801|Clostridia,21Z7Y@1506553|Lachnoclostridium	186801|Clostridia	H	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
TH2_k127_4461193_31	459349.CLOAM1184	8.97e-24	105.0	COG3411@1|root,COG3411@2|Bacteria,2NPST@2323|unclassified Bacteria	2|Bacteria	C	Ferredoxin	-	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K17992	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
TH2_k127_4461193_1	941824.TCEL_01276	1.549e-261	818.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,36EMP@31979|Clostridiaceae	186801|Clostridia	C	Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	hymB	-	1.12.1.3,1.17.1.11,1.6.5.3	ko:K00335,ko:K18331,ko:K22339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
TH2_k127_4461193_13	1304875.JAFZ01000001_gene1214	3.655e-100	349.0	COG3383@1|root,COG3383@2|Bacteria,3TAAU@508458|Synergistetes	508458|Synergistetes	C	-binding domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3
TH2_k127_4461193_22	515635.Dtur_0077	3.259e-57	208.0	COG1941@1|root,COG1941@2|Bacteria	2|Bacteria	C	coenzyme F420 hydrogenase activity	-	-	1.12.1.2	ko:K18007	-	-	-	-	ko00000,ko01000	-	-	-	Fe_hyd_lg_C,Fer4,Oxidored_q6
TH2_k127_4461193_4	309799.DICTH_1783	8.755e-187	595.0	COG3259@1|root,COG3259@2|Bacteria	2|Bacteria	C	Nickel-dependent hydrogenase	-	-	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
TH2_k127_4461193_32	56110.Oscil6304_5917	3.176e-22	102.0	COG0680@1|root,COG0680@2|Bacteria,1G7PP@1117|Cyanobacteria,1HC58@1150|Oscillatoriales	1117|Cyanobacteria	C	hydrogenase maturation protease	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4461193_38	891968.Anamo_1414	3.423e-17	85.0	COG0375@1|root,COG0375@2|Bacteria,3TBGH@508458|Synergistetes	508458|Synergistetes	C	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
TH2_k127_4461193_12	880073.Calab_2035	5.414e-108	356.0	COG0543@1|root,COG0543@2|Bacteria,2NNUA@2323|unclassified Bacteria	2|Bacteria	CH	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	gltA	-	1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14	ko:K00266,ko:K00528,ko:K02823	ko00240,ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00240,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248,R10159	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,Fer4_20,NAD_binding_1,Pyr_redox_2
TH2_k127_4461193_3	880073.Calab_2036	8.463e-198	626.0	COG0493@1|root,COG0493@2|Bacteria,2NNXN@2323|unclassified Bacteria	2|Bacteria	E	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,Fer4_20,NAD_binding_1,Pyr_redox_2
TH2_k127_4461193_41	933262.AXAM01000023_gene644	7.025e-09	69.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MJ5T@213118|Desulfobacterales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon-2	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
TH2_k127_4504926_0	1382359.JIAL01000001_gene1553	6.438e-198	625.0	COG0499@1|root,COG0499@2|Bacteria,3Y2J2@57723|Acidobacteria,2JIFV@204432|Acidobacteriia	204432|Acidobacteriia	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
TH2_k127_4504926_1	290397.Adeh_3814	4.052e-96	329.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2YVGM@29|Myxococcales	28221|Deltaproteobacteria	I	CoA-substrate-specific enzyme activase	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
TH2_k127_4512867_21	909663.KI867150_gene1450	9.186e-18	94.0	COG3746@1|root,COG3746@2|Bacteria,1MV8P@1224|Proteobacteria,42VG8@68525|delta/epsilon subdivisions,2WSEH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Putative porin	-	-	-	-	-	-	-	-	-	-	-	-	Porin_5
TH2_k127_4512867_12	497964.CfE428DRAFT_0566	8.284e-49	183.0	COG0590@1|root,COG0590@2|Bacteria,46SZZ@74201|Verrucomicrobia	74201|Verrucomicrobia	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
TH2_k127_4512867_9	1121918.ARWE01000001_gene2558	6.275e-70	247.0	COG1235@1|root,COG1235@2|Bacteria,1MVJH@1224|Proteobacteria,42Q0E@68525|delta/epsilon subdivisions,2WITX@28221|Deltaproteobacteria,43SDK@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	3.1.4.55	ko:K06167	ko00440,map00440	-	R10205	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
TH2_k127_4512867_11	3075.A0A087SKI8	1.396e-53	195.0	COG0221@1|root,KOG1626@2759|Eukaryota,37R74@33090|Viridiplantae	33090|Viridiplantae	C	soluble inorganic	-	GO:0003674,GO:0003824,GO:0004427,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0008150,GO:0010035,GO:0010038,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0042221,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0046686,GO:0050896	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
TH2_k127_4512867_4	118168.MC7420_5104	4.393e-123	405.0	COG3288@1|root,COG3288@2|Bacteria,1G1D1@1117|Cyanobacteria,1H7A5@1150|Oscillatoriales	1117|Cyanobacteria	C	NAD NADP transhydrogenase alpha subunit	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
TH2_k127_4512867_19	1173022.Cri9333_2730	1.262e-26	111.0	COG3288@1|root,COG3288@2|Bacteria,1G711@1117|Cyanobacteria,1HBSJ@1150|Oscillatoriales	1117|Cyanobacteria	C	NAD NADP transhydrogenase alpha subunit	pntA-2	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
TH2_k127_4512867_2	1170562.Cal6303_3051	6.947e-159	518.0	COG1282@1|root,COG1282@2|Bacteria,1G2AX@1117|Cyanobacteria,1HII6@1161|Nostocales	1117|Cyanobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
TH2_k127_4512867_20	452637.Oter_2586	7.285e-24	111.0	2E533@1|root,32ZW9@2|Bacteria,46SZX@74201|Verrucomicrobia,3K856@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4512867_17	497964.CfE428DRAFT_5780	4.574e-43	168.0	COG0805@1|root,COG0805@2|Bacteria,46T26@74201|Verrucomicrobia	74201|Verrucomicrobia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
TH2_k127_4512867_22	1121859.KB890740_gene3888	3.732e-11	66.0	COG1826@1|root,COG1826@2|Bacteria,4NUNH@976|Bacteroidetes,47S09@768503|Cytophagia	976|Bacteroidetes	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
TH2_k127_4512867_18	485915.Dret_1584	2.157e-28	122.0	COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,42R5H@68525|delta/epsilon subdivisions,2WNZS@28221|Deltaproteobacteria,2MC3Y@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Belongs to the ompA family	pal	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
TH2_k127_4512867_7	497964.CfE428DRAFT_5284	1.328e-75	271.0	COG0823@1|root,COG2885@1|root,COG0823@2|Bacteria,COG2885@2|Bacteria,46SSK@74201|Verrucomicrobia	74201|Verrucomicrobia	U	WD40-like Beta Propeller Repeat	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
TH2_k127_4512867_25	1156937.MFUM_970044	0.0002051	53.0	COG0810@1|root,COG0810@2|Bacteria,46ZFJ@74201|Verrucomicrobia,37GZ9@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	TonB C terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_2
TH2_k127_4512867_24	909663.KI867150_gene987	1.918e-07	61.0	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,42U00@68525|delta/epsilon subdivisions,2WQD4@28221|Deltaproteobacteria,2MQKE@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	Biopolymer transport protein ExbD/TolR	tolR	-	-	ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	ExbD
TH2_k127_4512867_16	497964.CfE428DRAFT_5288	2.023e-44	172.0	COG0811@1|root,COG0811@2|Bacteria,46V4I@74201|Verrucomicrobia	74201|Verrucomicrobia	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
TH2_k127_4512867_23	1210884.HG799476_gene15349	1.041e-07	60.0	2E4YE@1|root,32ZSA@2|Bacteria,2J15E@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4512867_15	344747.PM8797T_17212	2.705e-45	180.0	COG1649@1|root,COG1649@2|Bacteria,2IX7D@203682|Planctomycetes	203682|Planctomycetes	S	Glycosyl hydrolase-like 10	-	-	-	-	-	-	-	-	-	-	-	-	GHL10
TH2_k127_4512867_6	497964.CfE428DRAFT_0890	1.4e-80	277.0	COG0287@1|root,COG0287@2|Bacteria,46SSN@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Prephenate dehydrogenase	tyrA	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
TH2_k127_4512867_13	880073.Calab_0765	5.521e-46	176.0	COG0565@1|root,COG0565@2|Bacteria,2NQ39@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	trmJ	-	2.1.1.200,3.5.1.19,6.1.1.16	ko:K01883,ko:K02533,ko:K08281,ko:K15396	ko00760,ko00970,ko01100,map00760,map00970,map01100	M00359,M00360	R01268,R03650	RC00055,RC00100,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	SpoU_methylase
TH2_k127_4512867_14	504728.K649_00455	8.858e-46	171.0	COG1490@1|root,COG1490@2|Bacteria,1WJUX@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
TH2_k127_4512867_5	1168034.FH5T_18840	8.218e-121	402.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
TH2_k127_4512867_8	1131269.AQVV01000001_gene1323	3.425e-70	254.0	2DRTQ@1|root,32URN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4512867_1	497964.CfE428DRAFT_5899	1.589e-180	576.0	COG4992@1|root,COG4992@2|Bacteria,46UBT@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Aminotransferase class-III	-	-	2.6.1.13	ko:K00819	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R00667	RC00006,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
TH2_k127_4512867_3	497964.CfE428DRAFT_4581	9.195e-139	468.0	COG0793@1|root,COG0793@2|Bacteria,46S88@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Belongs to the peptidase S41A family	prc	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DUF3340,PDZ,Peptidase_S41
TH2_k127_4512867_10	313628.LNTAR_19802	2.42e-56	214.0	COG2974@1|root,COG2974@2|Bacteria	2|Bacteria	L	May be involved in recombination	-	-	-	ko:K03554	-	-	-	-	ko00000,ko03400	-	-	-	RdgC
TH2_k127_4512867_0	497964.CfE428DRAFT_0155	2.054e-227	721.0	COG0142@1|root,COG1852@1|root,COG0142@2|Bacteria,COG1852@2|Bacteria,46TEA@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Protein of unknown function DUF116	-	-	-	-	-	-	-	-	-	-	-	-	DUF116,polyprenyl_synt
TH2_k127_4521602_2	330214.NIDE2550	1.463e-31	128.0	COG0161@1|root,COG0161@2|Bacteria,3J0D9@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TH2_k127_4521602_0	1396418.BATQ01000024_gene5207	1.08e-113	379.0	COG0156@1|root,COG0156@2|Bacteria,46TTU@74201|Verrucomicrobia,2ITJB@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	Aminotransferase class I and II	-	-	2.3.1.47	ko:K00652	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03210,R10124	RC00004,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TH2_k127_4521602_1	497964.CfE428DRAFT_2596	3.263e-73	262.0	COG0402@1|root,COG0402@2|Bacteria,46TB5@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Amidohydrolase family	ssnA	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TH2_k127_4525055_2	452637.Oter_1455	1.279e-25	119.0	COG0845@1|root,COG0845@2|Bacteria,46US2@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
TH2_k127_4525055_1	452637.Oter_1456	1.254e-61	234.0	COG1538@1|root,COG1538@2|Bacteria,46TY1@74201|Verrucomicrobia	74201|Verrucomicrobia	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TH2_k127_4525055_3	1223410.KN050846_gene941	8.651e-20	94.0	COG0607@1|root,30IQR@2|Bacteria,4NVMW@976|Bacteroidetes,1I52X@117743|Flavobacteriia	976|Bacteroidetes	P	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
TH2_k127_4525055_4	1125863.JAFN01000001_gene1367	8.078e-13	72.0	COG5660@1|root,COG5660@2|Bacteria	2|Bacteria	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
TH2_k127_4525055_5	1521187.JPIM01000098_gene3783	2.945e-12	77.0	COG4191@1|root,COG4191@2|Bacteria,2G9W6@200795|Chloroflexi,37834@32061|Chloroflexia	32061|Chloroflexia	T	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,Response_reg,dCache_1
TH2_k127_4525055_0	1449050.JNLE01000003_gene2230	5.752e-110	379.0	COG3291@1|root,COG3420@1|root,COG3291@2|Bacteria,COG3420@2|Bacteria,1UY76@1239|Firmicutes,25G76@186801|Clostridia,36PFI@31979|Clostridiaceae	186801|Clostridia	P	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
TH2_k127_4587370_1	497964.CfE428DRAFT_0232	1.43e-23	104.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4587370_0	1123070.KB899247_gene1528	4.271e-249	810.0	COG0553@1|root,COG0553@2|Bacteria,46YZ0@74201|Verrucomicrobia,2ITIC@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	SNF2 family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
TH2_k127_4622555_0	794903.OPIT5_26140	0.0	1166.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,46TNN@74201|Verrucomicrobia,3K7A5@414999|Opitutae	414999|Opitutae	G	Belongs to the PEP-utilizing enzyme family	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
TH2_k127_4637745_4	1499967.BAYZ01000147_gene687	6.984e-12	68.0	2EDIX@1|root,337ET@2|Bacteria	2|Bacteria	S	tagaturonate epimerase	-	-	-	-	-	-	-	-	-	-	-	-	UxaE
TH2_k127_4637745_2	1313265.JNIE01000003_gene1353	1.145e-36	147.0	COG0176@1|root,COG0176@2|Bacteria,2G3ST@200783|Aquificae	200783|Aquificae	F	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
TH2_k127_4637745_3	452637.Oter_0795	2.854e-15	87.0	2E5WH@1|root,32RS6@2|Bacteria	2|Bacteria	J	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
TH2_k127_4637745_0	697281.Mahau_2275	1.081e-58	214.0	COG1028@1|root,COG1028@2|Bacteria,1TPZ8@1239|Firmicutes,24903@186801|Clostridia,42GQ3@68295|Thermoanaerobacterales	186801|Clostridia	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	1.1.1.127,1.1.1.69	ko:K00046,ko:K00065	ko00040,map00040	-	R01542	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
TH2_k127_4637745_5	1040982.AXAL01000027_gene3126	3.61e-06	53.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TWBA@28211|Alphaproteobacteria,43HY8@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
TH2_k127_4637745_1	1244869.H261_19853	9.33e-43	168.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TWBA@28211|Alphaproteobacteria,2JR5X@204441|Rhodospirillales	204441|Rhodospirillales	C	Transketolase, pyrimidine binding domain	-	-	-	-	-	-	-	-	-	-	-	-	E1_dh,Transket_pyr,Transketolase_C
TH2_k127_4648848_0	382464.ABSI01000017_gene26	9.245e-221	700.0	COG0674@1|root,COG0674@2|Bacteria,46SM9@74201|Verrucomicrobia,2IV6Q@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	-	-	-	-	-	-	-	-	-	-	PFOR_II,POR,POR_N
TH2_k127_4648848_1	497964.CfE428DRAFT_4282	2.698e-128	417.0	COG1013@1|root,COG1013@2|Bacteria,46SRY@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
TH2_k127_4648848_6	290318.Cvib_0492	1.78e-83	287.0	COG1968@1|root,COG1968@2|Bacteria,1FDGJ@1090|Chlorobi	1090|Chlorobi	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
TH2_k127_4648848_3	671143.DAMO_2461	4.187e-122	407.0	COG1109@1|root,COG1109@2|Bacteria,2NNTH@2323|unclassified Bacteria	2|Bacteria	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	femD	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TH2_k127_4648848_10	497964.CfE428DRAFT_1557	2.355e-24	111.0	2F9IJ@1|root,341UX@2|Bacteria,46VNE@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4648848_7	1396141.BATP01000006_gene5486	3.441e-60	211.0	2DHFW@1|root,2ZZKM@2|Bacteria,46SNY@74201|Verrucomicrobia,2IVW8@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4648848_5	1382359.JIAL01000001_gene72	3.351e-93	314.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	4.2.1.44,5.1.3.22	ko:K03079,ko:K03335	ko00040,ko00053,ko00562,ko01100,ko01120,map00040,map00053,map00562,map01100,map01120	M00550	R02782,R03244,R05659	RC00540,RC00782,RC01448	ko00000,ko00001,ko00002,ko01000	-	-	-	AP_endonuc_2
TH2_k127_4648848_2	794903.OPIT5_06015	1.152e-122	401.0	COG2084@1|root,COG2084@2|Bacteria,46S95@74201|Verrucomicrobia,3K74D@414999|Opitutae	414999|Opitutae	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
TH2_k127_4648848_4	497964.CfE428DRAFT_2387	5.473e-94	315.0	COG0491@1|root,COG0491@2|Bacteria,46S7X@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TH2_k127_4648848_9	1403819.BATR01000094_gene2949	2.058e-32	129.0	COG0292@1|root,COG0292@2|Bacteria,46SZW@74201|Verrucomicrobia,2IUFE@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
TH2_k127_4648848_11	167539.Pro_1821	1.904e-10	65.0	COG0291@1|root,COG0291@2|Bacteria,1G8Z8@1117|Cyanobacteria,1MN4J@1212|Prochloraceae	1117|Cyanobacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
TH2_k127_4648848_8	436114.SYO3AOP1_0679	4.019e-51	191.0	COG0290@1|root,COG0290@2|Bacteria,2G432@200783|Aquificae	200783|Aquificae	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
TH2_k127_4667435_2	234267.Acid_7187	5.611e-100	347.0	COG0457@1|root,COG0457@2|Bacteria,3Y3RA@57723|Acidobacteria	57723|Acidobacteria	M	SMART Tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8
TH2_k127_4667435_0	497964.CfE428DRAFT_1607	0.0	1338.0	COG1048@1|root,COG1048@2|Bacteria,46SFS@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
TH2_k127_4667435_4	497964.CfE428DRAFT_1793	1.466e-78	269.0	COG0130@1|root,COG0130@2|Bacteria,46SJR@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C_2,TruB_N
TH2_k127_4667435_1	1123371.ATXH01000009_gene1107	3.527e-172	554.0	COG0172@1|root,COG0172@2|Bacteria,2GGY4@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
TH2_k127_4667435_3	370438.PTH_0197	1.063e-82	294.0	COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,248TY@186801|Clostridia,260U4@186807|Peptococcaceae	186801|Clostridia	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
TH2_k127_4667435_5	1304885.AUEY01000104_gene2548	2.966e-45	166.0	COG0702@1|root,COG0702@2|Bacteria,1Q438@1224|Proteobacteria,439WM@68525|delta/epsilon subdivisions,2X29K@28221|Deltaproteobacteria,2MPBK@213118|Desulfobacterales	28221|Deltaproteobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
TH2_k127_4669323_2	247490.KSU1_B0680	8.934e-57	212.0	COG2067@1|root,COG2067@2|Bacteria	2|Bacteria	I	long-chain fatty acid transporting porin activity	fadL	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
TH2_k127_4669323_0	1125863.JAFN01000001_gene1446	8.462e-128	424.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH2_k127_4669323_1	497964.CfE428DRAFT_5468	1.356e-57	222.0	COG5000@1|root,COG5000@2|Bacteria,46THS@74201|Verrucomicrobia	74201|Verrucomicrobia	T	ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
TH2_k127_4673430_8	452637.Oter_0305	7.284e-83	280.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Fer4_12,Radical_SAM
TH2_k127_4673430_3	1191523.MROS_1921	9.56e-142	460.0	COG0126@1|root,COG0126@2|Bacteria	2|Bacteria	F	phosphoglycerate kinase activity	pgk	GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
TH2_k127_4673430_4	349161.Dred_2989	3.557e-89	301.0	COG0149@1|root,COG0149@2|Bacteria,1TP2F@1239|Firmicutes,248JN@186801|Clostridia,260CH@186807|Peptococcaceae	186801|Clostridia	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
TH2_k127_4673430_15	478741.JAFS01000001_gene1814	6.981e-05	52.0	COG1314@1|root,COG1314@2|Bacteria,46T75@74201|Verrucomicrobia,37H11@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	U	Preprotein translocase SecG subunit	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
TH2_k127_4673430_2	478741.JAFS01000001_gene1815	1.862e-177	576.0	COG4166@1|root,COG4166@2|Bacteria,46SBG@74201|Verrucomicrobia,37GEP@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	E	Bacterial extracellular solute-binding proteins, family 5 Middle	oppA	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
TH2_k127_4673430_5	1131269.AQVV01000006_gene529	1.949e-85	302.0	COG0601@1|root,COG0601@2|Bacteria	2|Bacteria	P	nitrogen compound transport	oppB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K02033,ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
TH2_k127_4673430_6	314285.KT71_06839	2.606e-85	293.0	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,1RN08@1236|Gammaproteobacteria,1J7NZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TH2_k127_4673430_1	497964.CfE428DRAFT_6515	0.0	1078.0	COG0457@1|root,COG0457@2|Bacteria,46UKC@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Peptidase_C39 like family	-	-	-	-	-	-	-	-	-	-	-	-	FAT,Peptidase_C39_2
TH2_k127_4673430_10	416591.Tlet_1830	2.437e-36	151.0	COG4826@1|root,COG4826@2|Bacteria,2GDUM@200918|Thermotogae	200918|Thermotogae	O	SERine  Proteinase INhibitors	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
TH2_k127_4673430_12	8049.ENSGMOP00000014919	3.385e-18	93.0	COG4826@1|root,KOG2392@2759|Eukaryota,38VR6@33154|Opisthokonta,3BBFJ@33208|Metazoa,3CV81@33213|Bilateria,48177@7711|Chordata,49259@7742|Vertebrata,49QIX@7898|Actinopterygii	33208|Metazoa	V	Serpin peptidase inhibitor, clade B (ovalbumin), member 1	SERPINB1	GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0004857,GO:0004866,GO:0004867,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0006810,GO:0006887,GO:0006955,GO:0008150,GO:0009892,GO:0009894,GO:0009987,GO:0010466,GO:0010605,GO:0010951,GO:0012505,GO:0016192,GO:0019222,GO:0030141,GO:0030162,GO:0030234,GO:0030414,GO:0031323,GO:0031324,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0032268,GO:0032269,GO:0032940,GO:0034774,GO:0036230,GO:0042119,GO:0042176,GO:0043086,GO:0043226,GO:0043227,GO:0043229,GO:0043233,GO:0043299,GO:0043312,GO:0044092,GO:0044421,GO:0044422,GO:0044424,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0045861,GO:0046903,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051179,GO:0051234,GO:0051246,GO:0051248,GO:0051336,GO:0051346,GO:0052547,GO:0052548,GO:0060205,GO:0060255,GO:0061134,GO:0061135,GO:0065007,GO:0065009,GO:0070013,GO:0080090,GO:0097708,GO:0098772,GO:0099503	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
TH2_k127_4673430_0	243231.GSU2758	0.0	2471.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42P3V@68525|delta/epsilon subdivisions,2WKWV@28221|Deltaproteobacteria,43TF0@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA1	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
TH2_k127_4673430_14	698757.Pogu_2361	7.673e-07	59.0	arCOG05472@1|root,arCOG05472@2157|Archaea,2XQTA@28889|Crenarchaeota	28889|Crenarchaeota	S	zinc ion binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF2204
TH2_k127_4673430_9	118163.Ple7327_2124	6.658e-65	248.0	COG3551@1|root,COG3551@2|Bacteria	2|Bacteria	J	Protein conserved in bacteria	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_transf_4,Glyco_transf_41,Glycos_transf_1,Glycos_transf_2,Sulfotransfer_3
TH2_k127_4673430_11	351348.Maqu_2636	4.123e-36	158.0	COG3551@1|root,COG3551@2|Bacteria,1MYJC@1224|Proteobacteria,1S8FM@1236|Gammaproteobacteria,46B9I@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
TH2_k127_4673430_13	1121904.ARBP01000022_gene3465	1.145e-13	81.0	COG0457@1|root,COG0457@2|Bacteria,4NU90@976|Bacteroidetes	976|Bacteroidetes	S	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1
TH2_k127_4673430_16	1122176.KB903619_gene5307	0.0004353	44.0	2DKVZ@1|root,30IFS@2|Bacteria	2|Bacteria	S	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1,Sulfotransfer_3
TH2_k127_4685034_7	391612.CY0110_08551	8.375e-90	324.0	2DBBA@1|root,2Z86Y@2|Bacteria,1G1AR@1117|Cyanobacteria,3KG9B@43988|Cyanothece	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4685034_11	1123508.JH636440_gene2309	1.089e-07	65.0	COG1520@1|root,COG1520@2|Bacteria,2IWVJ@203682|Planctomycetes	203682|Planctomycetes	S	WD40-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
TH2_k127_4685034_13	344747.PM8797T_02984	0.0007556	53.0	COG1520@1|root,COG1520@2|Bacteria,2IY9D@203682|Planctomycetes	203682|Planctomycetes	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
TH2_k127_4685034_8	313628.LNTAR_09229	9.307e-56	218.0	COG0627@1|root,COG0627@2|Bacteria	2|Bacteria	J	Serine hydrolase involved in the detoxification of formaldehyde	-	-	-	-	-	-	-	-	-	-	-	-	Esterase,Hepar_II_III,Hepar_II_III_N,OprD
TH2_k127_4685034_12	1229780.BN381_750002	1.099e-06	55.0	2C62F@1|root,335K1@2|Bacteria,2GS5K@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4685034_6	452637.Oter_2895	6.127e-91	310.0	COG1940@1|root,COG1940@2|Bacteria,46T0E@74201|Verrucomicrobia,3K8J6@414999|Opitutae	414999|Opitutae	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
TH2_k127_4685034_1	1121904.ARBP01000025_gene6118	7.429e-234	745.0	COG1874@1|root,COG1874@2|Bacteria,4NK6M@976|Bacteroidetes,47MV4@768503|Cytophagia	976|Bacteroidetes	G	Beta-galactosidase trimerisation domain	-	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_42,Glyco_hydro_42M
TH2_k127_4685034_2	452637.Oter_0912	2.443e-222	708.0	COG1132@1|root,COG1132@2|Bacteria,46YXP@74201|Verrucomicrobia,3K7FZ@414999|Opitutae	414999|Opitutae	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TH2_k127_4685034_3	448385.sce0180	6.33e-201	645.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42M01@68525|delta/epsilon subdivisions,2X1Y5@28221|Deltaproteobacteria,2YWWG@29|Myxococcales	28221|Deltaproteobacteria	P	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TH2_k127_4685034_10	794903.OPIT5_27545	5.852e-14	84.0	2EPKD@1|root,33H70@2|Bacteria,46WC0@74201|Verrucomicrobia,3K89T@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4685034_9	697282.Mettu_2235	6.418e-42	162.0	COG1309@1|root,COG1309@2|Bacteria,1NDME@1224|Proteobacteria,1SAB5@1236|Gammaproteobacteria,1XFPV@135618|Methylococcales	135618|Methylococcales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	DUF1956,TetR_N
TH2_k127_4685034_4	1232410.KI421421_gene3770	2.529e-136	453.0	COG1538@1|root,COG1538@2|Bacteria,1R816@1224|Proteobacteria,42QHQ@68525|delta/epsilon subdivisions,2WMDF@28221|Deltaproteobacteria,43SE8@69541|Desulfuromonadales	2|Bacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TH2_k127_4685034_5	1232410.KI421421_gene3769	3.588e-121	400.0	COG0845@1|root,COG0845@2|Bacteria,1PEVY@1224|Proteobacteria,42NTH@68525|delta/epsilon subdivisions,2WJ8N@28221|Deltaproteobacteria,43S96@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3
TH2_k127_4685034_0	1232410.KI421421_gene3768	0.0	1320.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria,43S1Y@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
TH2_k127_4700313_2	1403819.BATR01000137_gene4831	3.51e-135	452.0	COG0438@1|root,COG0438@2|Bacteria,46UG2@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TH2_k127_4700313_1	497964.CfE428DRAFT_5041	4.7e-155	511.0	COG0644@1|root,COG0644@2|Bacteria,46U5W@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Tryptophan halogenase	-	-	-	-	-	-	-	-	-	-	-	-	Trp_halogenase
TH2_k127_4700313_18	1396418.BATQ01000109_gene4734	1.695e-20	100.0	COG3161@1|root,COG3161@2|Bacteria,46WDJ@74201|Verrucomicrobia	74201|Verrucomicrobia	H	chorismate lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4700313_0	1396418.BATQ01000109_gene4733	3.565e-191	606.0	COG0635@1|root,COG0635@2|Bacteria,46U2R@74201|Verrucomicrobia,2IWKM@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TH2_k127_4700313_6	497964.CfE428DRAFT_5038	3.373e-103	348.0	COG1520@1|root,COG1520@2|Bacteria,46T0C@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM Pyrrolo-quinoline quinone	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_3
TH2_k127_4700313_15	794903.OPIT5_01055	1.149e-51	189.0	COG4636@1|root,COG4636@2|Bacteria,46VM4@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
TH2_k127_4700313_4	1469245.JFBG01000011_gene839	1.61e-115	398.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria	1224|Proteobacteria	E	ABC-Type Dipeptide Transport System Periplasmic Component	appA	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TH2_k127_4700313_10	1131269.AQVV01000020_gene2194	1.051e-85	296.0	COG0601@1|root,COG0601@2|Bacteria	2|Bacteria	P	nitrogen compound transport	oppB	-	-	ko:K02033,ko:K13894	ko02010,ko02024,map02010,map02024	M00239,M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.21,3.A.1.5.24	-	-	BPD_transp_1
TH2_k127_4700313_9	880072.Desac_2878	2.446e-88	305.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,42MFP@68525|delta/epsilon subdivisions,2WJ47@28221|Deltaproteobacteria,2MQ6J@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TH2_k127_4700313_3	1519464.HY22_11445	1.237e-122	402.0	COG0444@1|root,COG0444@2|Bacteria,1FDSN@1090|Chlorobi	1090|Chlorobi	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TH2_k127_4700313_5	941824.TCEL_00533	2.032e-108	362.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,36EGD@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
TH2_k127_4700313_12	335543.Sfum_1337	6.81e-81	293.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIU5@28221|Deltaproteobacteria,2MQZQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TH2_k127_4700313_16	1283300.ATXB01000001_gene2242	5.244e-39	160.0	COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,1S6JM@1236|Gammaproteobacteria,1XE76@135618|Methylococcales	135618|Methylococcales	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
TH2_k127_4700313_13	448385.sce7580	1.182e-69	261.0	COG1044@1|root,COG3064@1|root,COG1044@2|Bacteria,COG3064@2|Bacteria,1R0DU@1224|Proteobacteria,43CWB@68525|delta/epsilon subdivisions,2X84C@28221|Deltaproteobacteria,2YZ3S@29|Myxococcales	28221|Deltaproteobacteria	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S55
TH2_k127_4700313_11	234267.Acid_7185	2.122e-85	311.0	COG3386@1|root,COG3386@2|Bacteria,3Y2G7@57723|Acidobacteria	57723|Acidobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4700313_14	1262449.CP6013_3115	1.039e-64	228.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,36DXW@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TH2_k127_4700313_19	1172179.AUKV01000006_gene6247	3.799e-14	86.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria	201174|Actinobacteria	Q	ABC transporter (Permease)	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TH2_k127_4700313_7	697281.Mahau_2948	8.485e-98	333.0	COG0407@1|root,COG0407@2|Bacteria,1UY51@1239|Firmicutes,24DZF@186801|Clostridia,42FW9@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
TH2_k127_4700313_8	1142394.PSMK_08900	3.824e-93	312.0	COG5285@1|root,COG5285@2|Bacteria	2|Bacteria	Q	dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
TH2_k127_4700313_17	1294143.H681_06625	1.154e-28	126.0	COG4977@1|root,COG4977@2|Bacteria,1MXSX@1224|Proteobacteria,1T1HP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Transcriptional regulator	-	-	-	ko:K07506	-	-	-	-	ko00000,ko03000	-	-	-	AraC_binding,HTH_18,HTH_AraC
TH2_k127_4703961_7	1132509.C447_05503	4.018e-20	91.0	COG4147@1|root,arCOG01317@2157|Archaea,2XTSZ@28890|Euryarchaeota,23SPI@183963|Halobacteria	183963|Halobacteria	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	ssf	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
TH2_k127_4703961_8	1173023.KE650771_gene2825	1.965e-17	85.0	COG4147@1|root,COG4147@2|Bacteria,1G197@1117|Cyanobacteria,1JGTC@1189|Stigonemataceae	1117|Cyanobacteria	S	Sodium:solute symporter family	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
TH2_k127_4703961_9	1121929.KB898681_gene2020	1.533e-06	60.0	COG4147@1|root,COG4147@2|Bacteria,1UHT5@1239|Firmicutes,4HCF6@91061|Bacilli,4704K@74385|Gracilibacillus	91061|Bacilli	S	Sodium:solute symporter family	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
TH2_k127_4703961_4	497964.CfE428DRAFT_4167	2.354e-76	263.0	COG1208@1|root,COG1208@2|Bacteria,46SP1@74201|Verrucomicrobia	74201|Verrucomicrobia	JM	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
TH2_k127_4703961_1	452637.Oter_3498	1.6e-127	417.0	COG0216@1|root,COG0216@2|Bacteria,46S6F@74201|Verrucomicrobia,3K794@414999|Opitutae	414999|Opitutae	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
TH2_k127_4703961_6	497964.CfE428DRAFT_1496	6.179e-25	104.0	COG0254@1|root,COG0254@2|Bacteria,46T4W@74201|Verrucomicrobia	74201|Verrucomicrobia	J	ribosomal protein L31	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
TH2_k127_4703961_0	986075.CathTA2_1879	2.313e-164	527.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,4H9SD@91061|Bacilli	91061|Bacilli	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF3	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TH2_k127_4703961_5	497964.CfE428DRAFT_1901	7.745e-32	126.0	COG0236@1|root,COG0236@2|Bacteria,46T18@74201|Verrucomicrobia	74201|Verrucomicrobia	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
TH2_k127_4703961_2	485916.Dtox_1180	9.539e-82	278.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,260VS@186807|Peptococcaceae	186801|Clostridia	IQ	PFAM short chain dehydrogenase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TH2_k127_4703961_3	1185876.BN8_00570	2.411e-80	281.0	COG3408@1|root,COG3408@2|Bacteria,4NHHR@976|Bacteroidetes,47MK4@768503|Cytophagia	976|Bacteroidetes	G	Bacterial alpha-L-rhamnosidase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
TH2_k127_4737197_3	1144275.COCOR_00219	2.361e-67	241.0	COG1260@1|root,COG1260@2|Bacteria,1N0D9@1224|Proteobacteria,42R9P@68525|delta/epsilon subdivisions,2WMSU@28221|Deltaproteobacteria,2Z347@29|Myxococcales	28221|Deltaproteobacteria	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth,NAD_binding_5
TH2_k127_4737197_6	1396418.BATQ01000153_gene2269	1.352e-33	134.0	COG1610@1|root,COG1610@2|Bacteria,46T4B@74201|Verrucomicrobia,2IUKM@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Yqey-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
TH2_k127_4737197_7	631362.Thi970DRAFT_04947	2.559e-17	94.0	COG1459@1|root,COG1459@2|Bacteria,1NGI0@1224|Proteobacteria,1SHP6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	type II secretion system protein	-	-	-	ko:K02455	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSF
TH2_k127_4737197_1	1047013.AQSP01000140_gene2513	3.135e-87	299.0	COG1322@1|root,COG1322@2|Bacteria,2NPXU@2323|unclassified Bacteria	2|Bacteria	S	RmuC family	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
TH2_k127_4737197_5	481448.Minf_0015	1.267e-41	162.0	COG0688@1|root,COG0688@2|Bacteria,46VRI@74201|Verrucomicrobia,37GNN@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
TH2_k127_4737197_2	1403819.BATR01000096_gene3116	2.043e-68	243.0	COG1183@1|root,COG1183@2|Bacteria,46SK0@74201|Verrucomicrobia,2ITHZ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
TH2_k127_4737197_4	497964.CfE428DRAFT_5454	6.766e-66	235.0	COG0122@1|root,COG0122@2|Bacteria,46SVK@74201|Verrucomicrobia	74201|Verrucomicrobia	L	8-oxoguanine DNA glycosylase, N-terminal domain	alkA	-	4.2.99.18	ko:K03660	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,OGG_N
TH2_k127_4737197_0	497964.CfE428DRAFT_4279	4.212e-142	465.0	COG0773@1|root,COG0773@2|Bacteria,46THM@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Mur ligase middle domain protein	-	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TH2_k127_4810582_0	452637.Oter_0693	8.146e-175	572.0	COG0019@1|root,COG0019@2|Bacteria,46WJD@74201|Verrucomicrobia	74201|Verrucomicrobia	E	PFAM Orn DAP Arg decarboxylase 2	-	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
TH2_k127_4810582_1	251221.35211608	6.681e-136	445.0	COG1899@1|root,COG1899@2|Bacteria,1G448@1117|Cyanobacteria	1117|Cyanobacteria	O	Belongs to the deoxyhypusine synthase family	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
TH2_k127_4810582_3	204669.Acid345_4077	7.471e-41	168.0	COG3064@1|root,COG3064@2|Bacteria,3Y7SB@57723|Acidobacteria,2JN3R@204432|Acidobacteriia	204432|Acidobacteriia	M	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
TH2_k127_4810582_2	909663.KI867150_gene2891	2.612e-75	264.0	COG4786@1|root,COG4786@2|Bacteria,1MZXB@1224|Proteobacteria,42MTK@68525|delta/epsilon subdivisions,2WM8U@28221|Deltaproteobacteria,2MQWV@213462|Syntrophobacterales	28221|Deltaproteobacteria	N	Protein of unknown function (DUF2950)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2950
TH2_k127_4810582_4	1038869.AXAN01000016_gene1420	2.517e-21	100.0	2E5SP@1|root,330H2@2|Bacteria,1NDBY@1224|Proteobacteria,2VXDV@28216|Betaproteobacteria,1K76Z@119060|Burkholderiaceae	28216|Betaproteobacteria	S	YMGG-like Gly-zipper	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_YMGG
TH2_k127_4887759_0	861299.J421_0351	1.122e-189	607.0	COG1129@1|root,COG1129@2|Bacteria,1ZVAU@142182|Gemmatimonadetes	2|Bacteria	G	ABC transporter	rbsA	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
TH2_k127_4887759_1	861299.J421_0352	4.271e-131	429.0	COG1879@1|root,COG1879@2|Bacteria	2|Bacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
TH2_k127_4887759_2	861299.J421_0353	2.715e-106	358.0	COG1172@1|root,COG1172@2|Bacteria	2|Bacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
TH2_k127_4887759_4	926569.ANT_24920	3.083e-28	118.0	COG3458@1|root,COG3458@2|Bacteria,2G5R9@200795|Chloroflexi	200795|Chloroflexi	Q	PFAM Acetyl xylan esterase	-	-	3.1.1.41	ko:K01060	ko00311,ko01130,map00311,map01130	-	R03062	RC00020,RC00041	ko00000,ko00001,ko01000	-	-	-	AXE1
TH2_k127_4887759_3	459495.SPLC1_S032040	5.858e-56	201.0	COG4096@1|root,COG4096@2|Bacteria,1GR6F@1117|Cyanobacteria	1117|Cyanobacteria	V	Type I site-specific restriction-modification system, R (Restriction) subunit and related	-	-	3.1.21.5	ko:K01156	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	-
TH2_k127_4887759_5	370438.PTH_2877	5.629e-28	132.0	COG0358@1|root,COG3598@1|root,COG0358@2|Bacteria,COG3598@2|Bacteria,1UXUR@1239|Firmicutes,2594M@186801|Clostridia,262BM@186807|Peptococcaceae	186801|Clostridia	L	DNA primase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_25,Toprim_2
TH2_k127_4889967_6	313612.L8106_21679	8.997e-18	87.0	COG0463@1|root,COG0463@2|Bacteria,1G0TT@1117|Cyanobacteria,1H9MU@1150|Oscillatoriales	1117|Cyanobacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TH2_k127_4889967_5	497964.CfE428DRAFT_5168	2.779e-70	258.0	2DUSB@1|root,33S06@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4889967_4	497964.CfE428DRAFT_5168	2.624e-70	258.0	2DUSB@1|root,33S06@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4889967_0	497964.CfE428DRAFT_5165	9.462e-129	421.0	COG1131@1|root,COG1131@2|Bacteria,46UCK@74201|Verrucomicrobia	74201|Verrucomicrobia	V	PFAM ABC transporter related	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TH2_k127_4889967_2	497964.CfE428DRAFT_5164	6.177e-100	349.0	2EY1P@1|root,33RAP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4889967_3	404589.Anae109_0319	3.067e-75	264.0	COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,42QF3@68525|delta/epsilon subdivisions,2WKPQ@28221|Deltaproteobacteria,2YYXT@29|Myxococcales	28221|Deltaproteobacteria	J	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon	gluQ	-	6.1.1.17	ko:K01885,ko:K01894	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
TH2_k127_4889967_1	497964.CfE428DRAFT_4839	1.977e-116	387.0	COG0568@1|root,COG0568@2|Bacteria,46SJ8@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TH2_k127_4926292_2	1121861.KB899913_gene2193	1.378e-19	93.0	COG0346@1|root,COG0346@2|Bacteria,1RB65@1224|Proteobacteria,2U7DP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_4
TH2_k127_4926292_1	696369.KI912183_gene1371	1.354e-74	266.0	COG3875@1|root,COG3875@2|Bacteria,1TQ1C@1239|Firmicutes,247PH@186801|Clostridia,261WJ@186807|Peptococcaceae	186801|Clostridia	S	conserved protein (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
TH2_k127_4926292_0	469383.Cwoe_4325	8.633e-103	347.0	COG1172@1|root,COG1172@2|Bacteria,2GJDW@201174|Actinobacteria,4CQ95@84995|Rubrobacteria	84995|Rubrobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
TH2_k127_4926292_3	469383.Cwoe_4324	7.226e-09	61.0	COG1879@1|root,COG1879@2|Bacteria,2HFUY@201174|Actinobacteria,4CTTK@84995|Rubrobacteria	84995|Rubrobacteria	G	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
TH2_k127_4950907_4	1403819.BATR01000002_gene67	3.354e-30	138.0	COG0457@1|root,COG1450@1|root,COG0457@2|Bacteria,COG1450@2|Bacteria,46TXY@74201|Verrucomicrobia,2ITGX@203494|Verrucomicrobiae	203494|Verrucomicrobiae	NU	Bacterial type II and III secretion system protein	-	-	-	-	-	-	-	-	-	-	-	-	Secretin,TPR_16,TPR_8
TH2_k127_4950907_10	1396141.BATP01000025_gene899	0.0009062	51.0	28V7G@1|root,2ZHAM@2|Bacteria,46WJH@74201|Verrucomicrobia,2IUZ5@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4950907_1	497964.CfE428DRAFT_4611	5.241e-118	400.0	COG4972@1|root,COG4972@2|Bacteria,46UI7@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	Type IV pilus assembly protein PilM;	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
TH2_k127_4950907_8	497964.CfE428DRAFT_4612	6.073e-10	68.0	28VCA@1|root,2ZHF0@2|Bacteria,46WID@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_4950907_0	525904.Tter_1474	9.176e-253	805.0	COG0667@1|root,COG0673@1|root,COG0667@2|Bacteria,COG0673@2|Bacteria,2NP86@2323|unclassified Bacteria	2|Bacteria	C	Oxidoreductase family, NAD-binding Rossmann fold	strT	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red,GFO_IDH_MocA
TH2_k127_4950907_5	1396418.BATQ01000015_gene4294	2.32e-24	121.0	COG2982@1|root,COG2982@2|Bacteria,46SSM@74201|Verrucomicrobia,2IUJJ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	AsmA-like C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2
TH2_k127_4950907_3	765912.Thimo_1413	6.483e-88	305.0	COG4783@1|root,COG4783@2|Bacteria,1QUMJ@1224|Proteobacteria,1T2RP@1236|Gammaproteobacteria,1WXRA@135613|Chromatiales	135613|Chromatiales	S	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
TH2_k127_4950907_9	1349822.NSB1T_11020	2.724e-07	64.0	COG2211@1|root,COG2211@2|Bacteria,4NE3F@976|Bacteroidetes,2FMUY@200643|Bacteroidia,22WGR@171551|Porphyromonadaceae	976|Bacteroidetes	G	MFS/sugar transport protein	-	-	-	ko:K16211	-	-	-	-	ko00000,ko02000	2.A.2.6	-	-	MFS_1,MFS_2
TH2_k127_4950907_7	1307759.JOMJ01000003_gene337	5.601e-14	79.0	COG3071@1|root,COG3071@2|Bacteria,1N6Y8@1224|Proteobacteria,42WU5@68525|delta/epsilon subdivisions,2WSUR@28221|Deltaproteobacteria,2ME4G@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Protein of unknown function (DUF2905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2905
TH2_k127_4950907_2	1123070.KB899252_gene891	9.454e-106	357.0	COG0809@1|root,COG0809@2|Bacteria,46SDA@74201|Verrucomicrobia,2IU22@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
TH2_k127_4950907_6	240016.ABIZ01000001_gene5517	3.526e-14	79.0	COG1861@1|root,COG1861@2|Bacteria,46UVT@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
TH2_k127_5001593_0	309799.DICTH_1692	3.913e-108	378.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	bmnA	-	3.2.1.25	ko:K01192	ko00511,ko04142,map00511,map04142	-	-	-	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
TH2_k127_5001593_1	1173027.Mic7113_2698	2.372e-67	232.0	COG1225@1|root,COG1225@2|Bacteria,1G0JC@1117|Cyanobacteria,1H7GR@1150|Oscillatoriales	1117|Cyanobacteria	O	PFAM AhpC TSA family	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TH2_k127_5043660_3	1121406.JAEX01000002_gene760	1.224e-162	530.0	COG4992@1|root,COG4992@2|Bacteria,1R6U9@1224|Proteobacteria,42MZ8@68525|delta/epsilon subdivisions,2WMM3@28221|Deltaproteobacteria,2MG24@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Aminotransferase class-III	-	-	2.6.1.82	ko:K09251	ko00330,ko01100,map00330,map01100	-	R01155	RC00006,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
TH2_k127_5043660_1	1521187.JPIM01000074_gene2856	1.298e-172	555.0	COG1012@1|root,COG1012@2|Bacteria,2G5JE@200795|Chloroflexi,375BH@32061|Chloroflexia	32061|Chloroflexia	C	Belongs to the aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
TH2_k127_5043660_7	324602.Caur_2039	1.316e-48	184.0	COG0634@1|root,COG0634@2|Bacteria,2G6HX@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
TH2_k127_5043660_4	1499967.BAYZ01000108_gene2200	9.809e-100	360.0	COG0524@1|root,COG0524@2|Bacteria	2|Bacteria	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	-	-	2.7.1.15,2.7.1.20,2.7.1.213,2.7.1.218,2.7.1.73	ko:K00852,ko:K00856,ko:K10710,ko:K22026	ko00030,ko00230,ko00240,ko01100,map00030,map00230,map00240,map01100	-	R00185,R00513,R01051,R01131,R01228,R02750,R08124	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
TH2_k127_5043660_2	1536769.P40081_26265	2.171e-166	550.0	COG1554@1|root,COG1554@2|Bacteria,1TQMB@1239|Firmicutes,4HAVB@91061|Bacilli,26TAI@186822|Paenibacillaceae	91061|Bacilli	G	Glycosyl hydrolase family 65, N-terminal domain	-	-	2.4.1.332	ko:K04844,ko:K21355	-	-	-	-	ko00000,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
TH2_k127_5043660_5	1501230.ET33_15875	4.106e-95	319.0	COG3386@1|root,COG3386@2|Bacteria,1V1TK@1239|Firmicutes,4HG0A@91061|Bacilli,26S9U@186822|Paenibacillaceae	91061|Bacilli	G	SMP-30 Gluconolaconase LRE domain protein	yvrE	GO:0003674,GO:0003824,GO:0004341,GO:0005488,GO:0005509,GO:0005575,GO:0005576,GO:0005975,GO:0005996,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016051,GO:0016053,GO:0016787,GO:0016788,GO:0019752,GO:0019852,GO:0019853,GO:0042364,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046364,GO:0046394,GO:0046872,GO:0051186,GO:0051188,GO:0052689,GO:0071704,GO:1901576	-	ko:K14274	ko00040,map00040	-	R02427	RC00713	ko00000,ko00001,ko01000	-	-	-	SGL
TH2_k127_5043660_8	314230.DSM3645_16315	0.0003928	52.0	29X2I@1|root,30IR0@2|Bacteria,2J0YA@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1573)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1573
TH2_k127_5043660_0	1173026.Glo7428_0407	8.162e-217	693.0	COG2317@1|root,COG2317@2|Bacteria,1G143@1117|Cyanobacteria	1117|Cyanobacteria	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	cxp	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
TH2_k127_5043660_6	497964.CfE428DRAFT_3663	4.135e-54	201.0	COG1657@1|root,COG1657@2|Bacteria,46V9U@74201|Verrucomicrobia	74201|Verrucomicrobia	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans
TH2_k127_5059316_0	452637.Oter_2475	2.433e-251	788.0	COG0173@1|root,COG0173@2|Bacteria,46S7W@74201|Verrucomicrobia,3K79T@414999|Opitutae	414999|Opitutae	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
TH2_k127_5059316_2	478741.JAFS01000002_gene722	6.261e-126	415.0	COG0124@1|root,COG0124@2|Bacteria,46S7Y@74201|Verrucomicrobia,37G1T@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	J	Histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
TH2_k127_5059316_5	313628.LNTAR_04471	1.691e-28	123.0	COG0776@1|root,COG0776@2|Bacteria	2|Bacteria	L	regulation of translation	hup	-	-	ko:K03530,ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
TH2_k127_5059316_4	497964.CfE428DRAFT_1693	2.172e-75	263.0	COG0859@1|root,COG0859@2|Bacteria,46SZK@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
TH2_k127_5059316_7	1403819.BATR01000017_gene550	3.499e-12	75.0	2EEN4@1|root,338G1@2|Bacteria,46T5X@74201|Verrucomicrobia,2IUHT@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5059316_1	349741.Amuc_0849	2.41e-144	481.0	COG0621@1|root,COG0621@2|Bacteria,46S6B@74201|Verrucomicrobia,2ITRH@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
TH2_k127_5059316_3	1121430.JMLG01000029_gene1500	8.859e-77	262.0	COG0302@1|root,COG0302@2|Bacteria,1TRNM@1239|Firmicutes,24867@186801|Clostridia,25ZXN@186807|Peptococcaceae	186801|Clostridia	H	PFAM GTP cyclohydrolase I	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
TH2_k127_5059316_6	998674.ATTE01000001_gene3081	6.376e-28	115.0	COG1262@1|root,COG1262@2|Bacteria,1RH9I@1224|Proteobacteria,1SC50@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
TH2_k127_5063309_4	497964.CfE428DRAFT_1502	1.104e-30	127.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,MASE1,PAS_3
TH2_k127_5063309_3	1396141.BATP01000039_gene1347	2.99e-65	231.0	COG2197@1|root,COG2197@2|Bacteria,46V5Z@74201|Verrucomicrobia,2IUBG@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TH2_k127_5063309_1	1123070.KB899253_gene1115	4.13e-88	300.0	COG0331@1|root,COG0331@2|Bacteria,46SNS@74201|Verrucomicrobia,2ITTM@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	Acyl transferase domain	-	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
TH2_k127_5063309_0	247490.KSU1_C0520	1.706e-138	447.0	COG0031@1|root,COG0031@2|Bacteria,2IXCX@203682|Planctomycetes	203682|Planctomycetes	E	cysteine synthase	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TH2_k127_5063309_2	497964.CfE428DRAFT_2729	2.25e-76	263.0	COG1209@1|root,COG1209@2|Bacteria,46T9Q@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Nucleotidyl transferase	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TH2_k127_5063309_5	326427.Cagg_3191	8.827e-24	111.0	COG3429@1|root,COG3429@2|Bacteria,2G6ZV@200795|Chloroflexi,375YF@32061|Chloroflexia	32061|Chloroflexia	G	Glucose-6-phosphate dehydrogenase subunit	-	-	-	-	-	-	-	-	-	-	-	-	OpcA_G6PD_assem
TH2_k127_508902_8	635013.TherJR_0790	3.748e-83	290.0	COG0012@1|root,COG0012@2|Bacteria,1UIBA@1239|Firmicutes,24DM9@186801|Clostridia	186801|Clostridia	J	GTP binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_508902_7	192952.MM_2291	2.003e-85	288.0	COG1451@1|root,arCOG02625@2157|Archaea,2Y0AZ@28890|Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
TH2_k127_508902_0	240016.ABIZ01000001_gene5314	7.615e-241	765.0	COG0458@1|root,COG0458@2|Bacteria,46SBT@74201|Verrucomicrobia,2IU2N@203494|Verrucomicrobiae	203494|Verrucomicrobiae	EF	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
TH2_k127_508902_9	338963.Pcar_2841	3.06e-67	234.0	COG2365@1|root,COG3863@1|root,COG2365@2|Bacteria,COG3863@2|Bacteria,1RGE7@1224|Proteobacteria,42U1M@68525|delta/epsilon subdivisions,2WQE0@28221|Deltaproteobacteria,43W3C@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Dual specificity phosphatase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Y_phosphatase2
TH2_k127_508902_17	1120966.AUBU01000002_gene2001	0.0002366	51.0	COG2849@1|root,COG2849@2|Bacteria,4NU55@976|Bacteroidetes	976|Bacteroidetes	S	MORN repeat variant	-	-	-	-	-	-	-	-	-	-	-	-	MORN_2
TH2_k127_508902_15	1297742.A176_04135	3.198e-06	55.0	2EFSR@1|root,339IR@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2934)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2934
TH2_k127_508902_5	439235.Dalk_3089	6.029e-115	393.0	2A102@1|root,30P5F@2|Bacteria,1NQ9E@1224|Proteobacteria,433GU@68525|delta/epsilon subdivisions,2WXXA@28221|Deltaproteobacteria	1224|Proteobacteria	S	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	DUF3592
TH2_k127_508902_12	497964.CfE428DRAFT_3013	1.023e-26	116.0	2E6X2@1|root,331GI@2|Bacteria,46T38@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_508902_14	439235.Dalk_3087	4.935e-19	98.0	COG1763@1|root,COG1763@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	-	-	-	ko:K03753,ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	-
TH2_k127_508902_11	493475.GARC_1198	4.169e-34	136.0	COG3428@1|root,COG3428@2|Bacteria,1NHMM@1224|Proteobacteria	1224|Proteobacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
TH2_k127_508902_1	1125863.JAFN01000001_gene1869	1.148e-201	653.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,42M1G@68525|delta/epsilon subdivisions,2WJ7V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Phenylalanyl-tRNA synthetase, beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
TH2_k127_508902_2	497964.CfE428DRAFT_0415	3.586e-174	557.0	COG2256@1|root,COG2256@2|Bacteria,46S7H@74201|Verrucomicrobia	74201|Verrucomicrobia	L	AAA ATPase central domain protein	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
TH2_k127_508902_13	264732.Moth_2140	1.374e-26	121.0	COG0212@1|root,COG0212@2|Bacteria,1VA91@1239|Firmicutes,24N7H@186801|Clostridia,42GVE@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM 5-formyltetrahydrofolate cyclo-ligase	yqgN	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
TH2_k127_508902_4	649747.HMPREF0083_03567	2.962e-155	505.0	COG1418@1|root,COG1418@2|Bacteria,1TP48@1239|Firmicutes,4HC9J@91061|Bacilli,26RXS@186822|Paenibacillaceae	91061|Bacilli	S	Endoribonuclease that initiates mRNA decay	rny	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
TH2_k127_508902_6	330214.NIDE3722	8.014e-87	294.0	COG1692@1|root,COG1692@2|Bacteria,3J0JW@40117|Nitrospirae	40117|Nitrospirae	S	YmdB-like protein	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
TH2_k127_508902_10	1184267.A11Q_2108	9.561e-44	165.0	COG0727@1|root,COG0727@2|Bacteria,1N3F5@1224|Proteobacteria,42T7I@68525|delta/epsilon subdivisions,2MU1A@213481|Bdellovibrionales,2WPNZ@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
TH2_k127_508902_3	935948.KE386495_gene1290	1.428e-166	559.0	COG0383@1|root,COG0383@2|Bacteria,1V0Q3@1239|Firmicutes,24AMV@186801|Clostridia,42I1U@68295|Thermoanaerobacterales	186801|Clostridia	G	Alpha mannosidase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
TH2_k127_508902_16	1094466.KQS_09250	1.235e-05	59.0	COG0457@1|root,COG1729@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,4NE4W@976|Bacteroidetes,1HX2D@117743|Flavobacteriia,2NTCP@237|Flavobacterium	976|Bacteroidetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_21,TPR_6,TPR_8
TH2_k127_5118349_2	696369.KI912183_gene1371	4.913e-22	100.0	COG3875@1|root,COG3875@2|Bacteria,1TQ1C@1239|Firmicutes,247PH@186801|Clostridia,261WJ@186807|Peptococcaceae	186801|Clostridia	S	conserved protein (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
TH2_k127_5118349_0	324925.Ppha_0197	1.021e-47	185.0	COG1028@1|root,COG1028@2|Bacteria,1FDUA@1090|Chlorobi	1090|Chlorobi	IQ	Short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TH2_k127_5118349_3	1030157.AFMP01000031_gene3089	0.0005221	45.0	COG0346@1|root,COG0346@2|Bacteria,1PKG0@1224|Proteobacteria,2UZ6Y@28211|Alphaproteobacteria,2K88S@204457|Sphingomonadales	204457|Sphingomonadales	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TH2_k127_5118349_1	1122986.KB908321_gene1258	1.508e-22	104.0	COG3533@1|root,COG3533@2|Bacteria	2|Bacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Alginate_lyase,CBM_35,Glyco_hydro_127,Glyco_hydro_25,Laminin_G_3,Methyltransf_11,Prenyltrans,RHS_repeat,RicinB_lectin_2
TH2_k127_52108_2	926560.KE387023_gene3288	6.968e-13	81.0	COG4099@1|root,COG4099@2|Bacteria,1WMQ4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Phospholipase/Carboxylesterase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2,Esterase_phd
TH2_k127_52108_0	497964.CfE428DRAFT_4840	4.705e-205	650.0	COG0606@1|root,COG0606@2|Bacteria,46SAK@74201|Verrucomicrobia	74201|Verrucomicrobia	O	PFAM magnesium chelatase ChlI subunit	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
TH2_k127_52108_1	452471.Aasi_0340	5.92e-70	258.0	COG0457@1|root,COG0666@1|root,COG0790@1|root,COG1672@1|root,COG0457@2|Bacteria,COG0666@2|Bacteria,COG0790@2|Bacteria,COG1672@2|Bacteria,4NMWW@976|Bacteroidetes,47SGQ@768503|Cytophagia	976|Bacteroidetes	L	SUPERFAMILY SSF53098, Polynucleotidyl transferase, Ribonuclease H fold	-	-	-	-	-	-	-	-	-	-	-	-	DUF2974,NB-ARC,Sel1,TPR_10,TPR_12,TPR_2,TPR_7,TPR_8
TH2_k127_5210961_4	526224.Bmur_1111	1.332e-07	55.0	COG0230@1|root,COG0230@2|Bacteria,2J8S9@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
TH2_k127_5210961_3	879309.HMPREF9199_2018	2.907e-11	71.0	COG0594@1|root,COG0594@2|Bacteria,1VA78@1239|Firmicutes,4H5JA@909932|Negativicutes	909932|Negativicutes	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
TH2_k127_5210961_2	207954.MED92_02116	1.846e-20	100.0	COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,1SCG6@1236|Gammaproteobacteria,1XKYU@135619|Oceanospirillales	135619|Oceanospirillales	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
TH2_k127_5210961_0	583355.Caka_2475	5.607e-87	308.0	COG0706@1|root,COG0706@2|Bacteria,46SHI@74201|Verrucomicrobia,3K72P@414999|Opitutae	414999|Opitutae	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
TH2_k127_5210961_1	1396418.BATQ01000150_gene2225	4.004e-21	101.0	COG1847@1|root,COG1847@2|Bacteria,46VYD@74201|Verrucomicrobia,2IUMF@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	R3H domain	-	-	-	-	-	-	-	-	-	-	-	-	R3H
TH2_k127_5222081_6	633.DJ40_532	1.568e-08	56.0	2AQK9@1|root,31FT7@2|Bacteria,1RJJM@1224|Proteobacteria,1S4EW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5222081_5	411476.BACOVA_04364	1.106e-09	62.0	2AQK9@1|root,31FT7@2|Bacteria,4NMIG@976|Bacteroidetes,2FWGH@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5222081_4	1396418.BATQ01000052_gene43	3.791e-19	93.0	COG3440@1|root,COG3440@2|Bacteria,46XGT@74201|Verrucomicrobia,2IVVK@203494|Verrucomicrobiae	203494|Verrucomicrobiae	V	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_2
TH2_k127_5222081_0	41431.PCC8801_1673	3.748e-166	529.0	COG1902@1|root,COG1902@2|Bacteria,1FZYT@1117|Cyanobacteria,3KHA9@43988|Cyanothece	1117|Cyanobacteria	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	-	ko:K10680	ko00633,ko01120,map00633,map01120	-	R08014,R08017,R08042	RC00250	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN
TH2_k127_5222081_2	382464.ABSI01000011_gene2994	5.627e-55	199.0	2DQ7E@1|root,3353C@2|Bacteria,46SU5@74201|Verrucomicrobia,2IUQR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Domain of unknown function (DUF5069)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5069
TH2_k127_5222081_1	497964.CfE428DRAFT_4350	2.495e-75	256.0	COG1741@1|root,COG1741@2|Bacteria,46SRJ@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
TH2_k127_5284486_4	497964.CfE428DRAFT_6168	1.749e-23	106.0	COG2402@1|root,COG2402@2|Bacteria	2|Bacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TH2_k127_5284486_3	1321781.HMPREF1985_00775	5.684e-38	151.0	COG0424@1|root,COG0424@2|Bacteria,1V6FH@1239|Firmicutes,4H4NK@909932|Negativicutes	909932|Negativicutes	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
TH2_k127_5284486_0	278957.ABEA03000206_gene3779	1.384e-134	435.0	COG0379@1|root,COG0379@2|Bacteria,46SA1@74201|Verrucomicrobia,3K7P4@414999|Opitutae	414999|Opitutae	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
TH2_k127_5284486_5	240302.BN982_03646	2.529e-12	76.0	COG0730@1|root,COG0730@2|Bacteria,1TPMA@1239|Firmicutes,4HCYJ@91061|Bacilli,3NEE7@45667|Halobacillus	91061|Bacilli	S	Sulfite exporter TauE/SafE	yunE	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TH2_k127_5284486_1	247490.KSU1_B0631	1.752e-94	333.0	COG0265@1|root,COG0265@2|Bacteria,2IY5I@203682|Planctomycetes	203682|Planctomycetes	O	PDZ domain (Also known as DHR	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
TH2_k127_5284486_2	395495.Lcho_4288	8.797e-60	209.0	COG1061@1|root,COG3886@1|root,COG1061@2|Bacteria,COG3886@2|Bacteria,1MV9F@1224|Proteobacteria,2VHAI@28216|Betaproteobacteria,1KN6M@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	helicase superfamily c-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3427,Helicase_C,Methyltransf_25,Mrr_cat,PLDc_2,ResIII
TH2_k127_5423897_2	497964.CfE428DRAFT_1749	7.367e-36	141.0	COG0316@1|root,COG0316@2|Bacteria,46T1T@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
TH2_k127_5423897_1	1144275.COCOR_06959	1.021e-40	162.0	COG0404@1|root,COG0404@2|Bacteria,1QX3Y@1224|Proteobacteria,43BWD@68525|delta/epsilon subdivisions,2X775@28221|Deltaproteobacteria,2YVVR@29|Myxococcales	28221|Deltaproteobacteria	E	Glycine cleavage T-protein C-terminal barrel domain	-	-	2.1.2.10	ko:K00605,ko:K06980	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	GCV_T,GCV_T_C
TH2_k127_5423897_0	1131269.AQVV01000004_gene642	1.259e-48	188.0	COG0652@1|root,COG0652@2|Bacteria	2|Bacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiA	-	5.2.1.8	ko:K01802,ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
TH2_k127_5423897_3	794903.OPIT5_11525	8.131e-16	87.0	COG2165@1|root,COG2165@2|Bacteria,46Z9D@74201|Verrucomicrobia,3K9IE@414999|Opitutae	2|Bacteria	U	Protein of unknown function (DUF1559)	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,SBP_bac_10
TH2_k127_5423897_4	1396141.BATP01000022_gene358	8.851e-08	56.0	COG0737@1|root,COG0737@2|Bacteria,46X8F@74201|Verrucomicrobia,2IV06@203494|Verrucomicrobiae	203494|Verrucomicrobiae	F	Calcineurin-like phosphoesterase	-	-	3.1.3.5	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
TH2_k127_5427425_18	1396141.BATP01000030_gene3755	8.97e-24	105.0	COG2127@1|root,COG2127@2|Bacteria,46T8N@74201|Verrucomicrobia,2IUSR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	ATP-dependent Clp protease adaptor protein ClpS	-	-	-	-	-	-	-	-	-	-	-	-	ClpS
TH2_k127_5427425_14	452637.Oter_1864	1.182e-37	154.0	COG3327@1|root,COG3327@2|Bacteria,46W9G@74201|Verrucomicrobia	74201|Verrucomicrobia	K	negative regulation of DNA-templated transcription, initiation	-	-	-	ko:K02616	-	-	-	-	ko00000,ko03000	-	-	-	PaaX_C
TH2_k127_5427425_0	349741.Amuc_0808	1.821e-292	944.0	COG1643@1|root,COG1643@2|Bacteria,46TFT@74201|Verrucomicrobia,2IU1J@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Oligonucleotide/oligosaccharide-binding (OB)-fold	-	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
TH2_k127_5427425_17	382464.ABSI01000010_gene3603	7.735e-24	104.0	2DYNU@1|root,34AH1@2|Bacteria,46W0V@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5427425_10	663278.Ethha_1331	5.471e-53	191.0	COG0245@1|root,COG0245@2|Bacteria,1V3P0@1239|Firmicutes,24HCM@186801|Clostridia,3WITA@541000|Ruminococcaceae	186801|Clostridia	H	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
TH2_k127_5427425_3	1437425.CSEC_0579	9.964e-158	514.0	COG0215@1|root,COG0215@2|Bacteria,2JFNB@204428|Chlamydiae	204428|Chlamydiae	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
TH2_k127_5427425_15	1395516.PMO01_20155	1.761e-36	142.0	COG1393@1|root,COG1393@2|Bacteria,1MZ4Z@1224|Proteobacteria,1S8XH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	arsenate reductase	arsC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC
TH2_k127_5427425_2	1173029.JH980292_gene3369	8.258e-179	569.0	COG3172@1|root,COG3172@2|Bacteria,1G79P@1117|Cyanobacteria,1HG1E@1150|Oscillatoriales	1117|Cyanobacteria	H	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_28
TH2_k127_5427425_7	439235.Dalk_3487	8.636e-79	269.0	COG3201@1|root,COG3201@2|Bacteria	2|Bacteria	H	nicotinamide mononucleotide transporter	pnuC	-	-	ko:K03811	-	-	-	-	ko00000,ko02000	4.B.1.1	-	-	NMN_transporter
TH2_k127_5427425_8	497964.CfE428DRAFT_4834	3.327e-59	216.0	COG4589@1|root,COG4589@2|Bacteria,46SX9@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Cytidylyltransferase family	-	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
TH2_k127_5427425_6	1403819.BATR01000184_gene6352	9.7e-83	286.0	COG0020@1|root,COG0020@2|Bacteria,46SMY@74201|Verrucomicrobia,2IU5V@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	-	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
TH2_k127_5427425_4	748449.Halha_2595	4.682e-153	495.0	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,247RN@186801|Clostridia,3WAAB@53433|Halanaerobiales	186801|Clostridia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
TH2_k127_5427425_5	497964.CfE428DRAFT_2060	3.002e-92	314.0	COG0142@1|root,COG0142@2|Bacteria,46SKW@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
TH2_k127_5427425_9	497964.CfE428DRAFT_2400	5.688e-59	212.0	COG1595@1|root,COG1595@2|Bacteria,46SWN@74201|Verrucomicrobia	74201|Verrucomicrobia	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TH2_k127_5427425_13	481448.Minf_1854	2.264e-44	176.0	COG0265@1|root,COG0265@2|Bacteria,46T0K@74201|Verrucomicrobia,37GHR@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
TH2_k127_5427425_16	671143.DAMO_1369	1.636e-35	145.0	COG0204@1|root,COG0204@2|Bacteria,2NPW3@2323|unclassified Bacteria	2|Bacteria	I	Phosphate acyltransferases	cmk	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TH2_k127_5427425_11	497964.CfE428DRAFT_0888	6.292e-48	181.0	COG0283@1|root,COG0283@2|Bacteria	2|Bacteria	F	belongs to the cytidylate kinase family. Type 1 subfamily	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015939,GO:0015940,GO:0015949,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	1.17.7.4,2.5.1.19,2.7.1.26,2.7.4.25,2.7.7.2,6.3.2.1	ko:K00800,ko:K00945,ko:K02945,ko:K03527,ko:K03977,ko:K11753,ko:K13799	ko00240,ko00400,ko00410,ko00740,ko00770,ko00900,ko01100,ko01110,ko01130,ko01230,ko03010,map00240,map00400,map00410,map00740,map00770,map00900,map01100,map01110,map01130,map01230,map03010	M00022,M00052,M00096,M00119,M00125,M00178	R00158,R00161,R00512,R00549,R01665,R02473,R03460,R05884,R08210	RC00002,RC00017,RC00096,RC00141,RC00350,RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03009,ko03011	-	-	iPC815.YPO1391,iSDY_1059.SDY_2348	Cytidylate_kin
TH2_k127_5427425_12	1519464.HY22_03120	1.36e-44	169.0	COG1335@1|root,COG1335@2|Bacteria,1FE0F@1090|Chlorobi	1090|Chlorobi	Q	PFAM isochorismatase hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
TH2_k127_5427425_1	697281.Mahau_1944	4.81e-193	613.0	COG1486@1|root,COG1486@2|Bacteria,1TQ9I@1239|Firmicutes,24995@186801|Clostridia,42FX4@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM glycoside hydrolase, family 4	-	-	3.2.1.22	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
TH2_k127_5453928_6	223283.PSPTO_5540	2.645e-61	216.0	COG0204@1|root,COG0204@2|Bacteria,1RA8V@1224|Proteobacteria,1RSDQ@1236|Gammaproteobacteria,1Z94T@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	I	Phosphate acyltransferases	Z012_02630	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TH2_k127_5453928_2	631362.Thi970DRAFT_04636	1.288e-120	395.0	COG4589@1|root,COG4589@2|Bacteria,1MX58@1224|Proteobacteria,1RRAG@1236|Gammaproteobacteria,1WY6I@135613|Chromatiales	135613|Chromatiales	I	Cytidylyltransferase family	-	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
TH2_k127_5453928_1	497964.CfE428DRAFT_1237	1.349e-193	625.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
TH2_k127_5453928_10	1297742.A176_00684	2.851e-28	123.0	COG0671@1|root,COG1562@1|root,COG0671@2|Bacteria,COG1562@2|Bacteria,1QWXB@1224|Proteobacteria,43CXQ@68525|delta/epsilon subdivisions	1224|Proteobacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2,PAP2_3
TH2_k127_5453928_3	497964.CfE428DRAFT_1235	5.333e-93	316.0	COG3239@1|root,COG3239@2|Bacteria	2|Bacteria	I	unsaturated fatty acid biosynthetic process	desA	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
TH2_k127_5453928_8	1144275.COCOR_02780	3.484e-48	186.0	COG4638@1|root,COG4638@2|Bacteria,1MWU3@1224|Proteobacteria,437H0@68525|delta/epsilon subdivisions,2X2QC@28221|Deltaproteobacteria,2YXMK@29|Myxococcales	28221|Deltaproteobacteria	P	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases large terminal subunit	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
TH2_k127_5453928_9	1144275.COCOR_02776	3.304e-38	156.0	COG4875@1|root,COG4875@2|Bacteria	2|Bacteria	IQ	SnoaL-like domain	-	-	5.3.3.1	ko:K01822	ko00140,ko00984,ko01100,ko01120,map00140,map00984,map01100,map01120	M00107,M00110	R01837,R02216,R02499,R02840,R03327,R04163,R04678,R04849,R09955	RC00146,RC00762	ko00000,ko00001,ko00002,ko01000	-	-	-	CaMKII_AD,DUF4440,SnoaL_2,SnoaL_3
TH2_k127_5453928_0	497964.CfE428DRAFT_1238	2.376e-211	669.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
TH2_k127_5453928_11	497964.CfE428DRAFT_1239	2.216e-24	116.0	2BZ6D@1|root,2ZC6J@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5453928_7	32057.KB217478_gene4513	1.312e-60	217.0	2DBEV@1|root,2Z8UT@2|Bacteria,1G3XJ@1117|Cyanobacteria,1HJN5@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5453928_4	502025.Hoch_4770	1.23e-78	283.0	COG0318@1|root,COG0318@2|Bacteria,1PH7B@1224|Proteobacteria,42TTG@68525|delta/epsilon subdivisions,2WQEX@28221|Deltaproteobacteria,2YU8V@29|Myxococcales	28221|Deltaproteobacteria	IQ	GH3 auxin-responsive promoter	-	-	-	-	-	-	-	-	-	-	-	-	GH3
TH2_k127_5467045_1	1187851.A33M_1375	1.931e-120	419.0	COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,2TUMR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG0553 Superfamily II DNA RNA helicases, SNF2 family	-	-	-	ko:K03580	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Helicase_C,SNF2_N
TH2_k127_5467045_3	1552758.NC00_04510	4.891e-35	138.0	2EHW5@1|root,33BMQ@2|Bacteria,1P29Q@1224|Proteobacteria,1T710@1236|Gammaproteobacteria,1X8K7@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5467045_0	1142394.PSMK_25030	1.007e-280	882.0	COG0348@1|root,COG0492@1|root,COG0348@2|Bacteria,COG0492@2|Bacteria,2J1NR@203682|Planctomycetes	203682|Planctomycetes	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_5
TH2_k127_5467045_4	667632.KB890164_gene2070	0.0003437	49.0	COG3408@1|root,COG3408@2|Bacteria,1MW01@1224|Proteobacteria,2W0E8@28216|Betaproteobacteria,1K24K@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Glycogen debranching enzyme N terminal	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
TH2_k127_5467045_2	1496688.ER33_11555	2.683e-53	193.0	COG3408@1|root,COG3408@2|Bacteria,1G2AS@1117|Cyanobacteria,22THV@167375|Cyanobium	1117|Cyanobacteria	G	Amylo-alpha-1,6-glucosidase	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
TH2_k127_54783_2	1396418.BATQ01000014_gene4341	1.538e-47	174.0	28MGX@1|root,2ZATZ@2|Bacteria,46TJV@74201|Verrucomicrobia,2ITWK@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_54783_6	1396418.BATQ01000166_gene1838	1.14e-17	85.0	2FCWX@1|root,344ZT@2|Bacteria,46WDE@74201|Verrucomicrobia,2IUVW@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Ribonuclease toxin, BrnT, of type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	BrnT_toxin
TH2_k127_54783_4	497964.CfE428DRAFT_6148	1.728e-24	108.0	2DTD6@1|root,33JTS@2|Bacteria,46WA4@74201|Verrucomicrobia	74201|Verrucomicrobia	S	CopG antitoxin of type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	CopG_antitoxin
TH2_k127_54783_9	696747.NIES39_L02770	0.0001601	48.0	2C300@1|root,330JR@2|Bacteria,1G9IH@1117|Cyanobacteria,1HDB5@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Prokaryotic metallothionein	smtA	-	-	ko:K21904	-	-	-	-	ko00000	-	-	-	Metallothio_Pro
TH2_k127_54783_0	264732.Moth_0915	1.868e-103	350.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1TP4F@1239|Firmicutes,248MM@186801|Clostridia,42F0T@68295|Thermoanaerobacterales	186801|Clostridia	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
TH2_k127_54783_3	997346.HMPREF9374_3827	8.319e-28	124.0	COG1105@1|root,COG1105@2|Bacteria,1TQ36@1239|Firmicutes,4HANU@91061|Bacilli,27C2H@186824|Thermoactinomycetaceae	91061|Bacilli	H	Belongs to the carbohydrate kinase PfkB family. LacC subfamily	lacC	-	2.7.1.144	ko:K00917	ko00052,ko01100,map00052,map01100	-	R03236	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
TH2_k127_54783_1	1304866.K413DRAFT_4504	3.57e-55	199.0	COG0307@1|root,COG0307@2|Bacteria,1V1EP@1239|Firmicutes,24FVK@186801|Clostridia,36GCB@31979|Clostridiaceae	186801|Clostridia	H	riboflavin synthase, alpha subunit	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
TH2_k127_54783_7	478741.JAFS01000002_gene266	9.872e-10	71.0	COG0457@1|root,COG0457@2|Bacteria,46YVP@74201|Verrucomicrobia,37G32@326457|unclassified Verrucomicrobia	478741.JAFS01000002_gene266|-	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_54783_5	400682.PAC_15702655	6.127e-21	105.0	COG0666@1|root,KOG0502@2759|Eukaryota	2759|Eukaryota	J	nerve growth factor signaling pathway	-	GO:0003674,GO:0003712,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006355,GO:0006357,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141	-	ko:K21440,ko:K21486	-	-	-	-	ko00000,ko03036,ko04131	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5
TH2_k127_54783_8	1396141.BATP01000025_gene897	7.988e-06	57.0	COG0457@1|root,COG1450@1|root,COG0457@2|Bacteria,COG1450@2|Bacteria,46TXY@74201|Verrucomicrobia,2ITGX@203494|Verrucomicrobiae	203494|Verrucomicrobiae	NU	Bacterial type II and III secretion system protein	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin
TH2_k127_5490783_0	497964.CfE428DRAFT_1104	2.052e-216	701.0	COG5373@1|root,COG5373@2|Bacteria,46S9T@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Predicted membrane protein (DUF2339)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2339
TH2_k127_5496679_2	497964.CfE428DRAFT_1861	7.82e-17	89.0	COG1595@1|root,COG4194@1|root,COG1595@2|Bacteria,COG4194@2|Bacteria,46TQ4@74201|Verrucomicrobia	74201|Verrucomicrobia	K	RNA polymerase sigma factor, sigma-70 family	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2,TonB_C
TH2_k127_5496679_0	762903.Pedsa_0297	7.377e-42	171.0	COG5434@1|root,COG5434@2|Bacteria,4NEM8@976|Bacteroidetes	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 28 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_28,Pectate_lyase_3
TH2_k127_5496679_3	497964.CfE428DRAFT_1597	1.995e-07	58.0	COG1520@1|root,COG1520@2|Bacteria,46UCY@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
TH2_k127_5496679_1	411470.RUMGNA_00162	2.054e-20	96.0	COG1696@1|root,COG1696@2|Bacteria,1TP52@1239|Firmicutes,248V4@186801|Clostridia,3XYV7@572511|Blautia	186801|Clostridia	M	Psort location CytoplasmicMembrane, score 9.99	algI	-	-	ko:K19294	-	-	-	-	ko00000	-	-	-	MBOAT
TH2_k127_5511222_2	1207063.P24_09261	5.193e-76	256.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,2TQYQ@28211|Alphaproteobacteria,2JQA8@204441|Rhodospirillales	204441|Rhodospirillales	P	Phosphate transport system permease	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3333
TH2_k127_5511222_0	314230.DSM3645_15600	4.751e-116	381.0	COG1117@1|root,COG1117@2|Bacteria,2IWRV@203682|Planctomycetes	203682|Planctomycetes	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	-	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
TH2_k127_5511222_3	452637.Oter_2549	1.954e-74	257.0	COG0704@1|root,COG0704@2|Bacteria,46SUX@74201|Verrucomicrobia,3K824@414999|Opitutae	414999|Opitutae	P	Plays a role in the regulation of phosphate uptake	-	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
TH2_k127_5511222_1	497964.CfE428DRAFT_4164	1.53e-80	276.0	COG0483@1|root,COG0483@2|Bacteria,46T0Z@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Inositol monophosphatase family	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
TH2_k127_5511222_4	1232683.ADIMK_0432	2.719e-42	159.0	COG0824@1|root,COG0824@2|Bacteria,1RF7Q@1224|Proteobacteria,1S7PD@1236|Gammaproteobacteria,468NH@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_2
TH2_k127_5546934_3	1396418.BATQ01000170_gene2645	1.88e-135	451.0	COG0608@1|root,COG0608@2|Bacteria,46SNV@74201|Verrucomicrobia,2ITRD@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	DHHA1 domain	-	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
TH2_k127_5546934_12	1128427.KB904821_gene1362	6.772e-06	52.0	COG2931@1|root,COG3209@1|root,COG4733@1|root,COG2931@2|Bacteria,COG3209@2|Bacteria,COG4733@2|Bacteria,1G0ZC@1117|Cyanobacteria,1H8KD@1150|Oscillatoriales	1117|Cyanobacteria	Q	PFAM Hemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Chlam_PMP,DUF4114,He_PIG,fn3
TH2_k127_5546934_6	478741.JAFS01000002_gene444	4.095e-83	295.0	COG1030@1|root,COG1030@2|Bacteria,46TAS@74201|Verrucomicrobia,37G9H@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD,SDH_sah
TH2_k127_5546934_10	1401067.HMPREF0872_07880	4.482e-13	76.0	COG1030@1|root,COG1030@2|Bacteria	2|Bacteria	-	-	yqeZ	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD,SDH_sah
TH2_k127_5546934_4	278957.ABEA03000094_gene4806	1.376e-128	420.0	COG4864@1|root,COG4864@2|Bacteria,46TWZ@74201|Verrucomicrobia,3K7TX@414999|Opitutae	414999|Opitutae	S	UPF0365 protein	-	-	-	-	-	-	-	-	-	-	-	-	YdfA_immunity
TH2_k127_5546934_1	497964.CfE428DRAFT_4290	2.763e-157	507.0	COG0448@1|root,COG0448@2|Bacteria,46SG2@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Belongs to the bacterial plant glucose-1-phosphate adenylyltransferase family	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TH2_k127_5546934_2	240016.ABIZ01000001_gene1668	4.199e-143	464.0	COG3239@1|root,COG3239@2|Bacteria,46SX7@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Fatty acid desaturase	desA	-	1.14.19.23,1.14.19.45	ko:K10255	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
TH2_k127_5546934_5	1144275.COCOR_05670	6.397e-91	306.0	COG0863@1|root,COG0863@2|Bacteria,1NXST@1224|Proteobacteria,42Q3Q@68525|delta/epsilon subdivisions,2X5I3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	DNA methylase	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
TH2_k127_5546934_11	497964.CfE428DRAFT_0693	8.436e-12	78.0	COG2304@1|root,COG2304@2|Bacteria,46UCW@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Aerotolerance regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
TH2_k127_5546934_7	1121422.AUMW01000023_gene2749	1.064e-44	174.0	COG0132@1|root,COG0132@2|Bacteria,1UYA3@1239|Firmicutes,24F15@186801|Clostridia,26262@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	-	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
TH2_k127_5546934_0	497964.CfE428DRAFT_4984	8.232e-242	771.0	COG1198@1|root,COG1198@2|Bacteria,46U3N@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
TH2_k127_5546934_9	1499967.BAYZ01000013_gene6458	1.322e-14	82.0	COG3127@1|root,COG3127@2|Bacteria	2|Bacteria	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TH2_k127_5546934_8	1123508.JH636442_gene4190	2.268e-15	81.0	COG1846@1|root,COG1846@2|Bacteria,2J085@203682|Planctomycetes	203682|Planctomycetes	K	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_34
TH2_k127_5548643_1	180332.JTGN01000004_gene2606	1.076e-65	233.0	COG0407@1|root,COG0407@2|Bacteria,1V4YU@1239|Firmicutes,24KSS@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
TH2_k127_5548643_0	1142394.PSMK_04920	8.369e-97	325.0	COG5285@1|root,COG5285@2|Bacteria	2|Bacteria	Q	dioxygenase activity	-	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016705,GO:0016706,GO:0016999,GO:0017000,GO:0017144,GO:0018130,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0046483,GO:0046872,GO:0046914,GO:0051213,GO:0055114,GO:0071704,GO:1901334,GO:1901336,GO:1901360,GO:1901362,GO:1901576	1.14.11.35	ko:K18056	ko01130,map01130	M00819	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhyH
TH2_k127_5548643_2	1121924.ATWH01000003_gene1588	5.462e-19	92.0	COG4977@1|root,COG4977@2|Bacteria,2IRGY@201174|Actinobacteria	201174|Actinobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TH2_k127_556243_5	864069.MicloDRAFT_00070330	2.056e-25	120.0	COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,2UCIY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	High confidence in function and specificity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,Nterm_IS4
TH2_k127_556243_1	1238450.VIBNISOn1_280037	3.123e-106	355.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,1RWHU@1236|Gammaproteobacteria,1Y26H@135623|Vibrionales	1224|Proteobacteria	C	Dehydrogenase E1 component	-	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
TH2_k127_556243_0	1238450.VIBNISOn1_280038	4.344e-135	440.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,1RP3G@1236|Gammaproteobacteria,1XV36@135623|Vibrionales	135623|Vibrionales	C	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit	pdhB	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
TH2_k127_556243_2	1238450.VIBNISOn1_280040	5.476e-97	325.0	COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,1RQUC@1236|Gammaproteobacteria,1XT4A@135623|Vibrionales	135623|Vibrionales	G	in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
TH2_k127_556243_4	349163.Acry_2821	2.631e-68	248.0	COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,2TRXM@28211|Alphaproteobacteria,2JPJK@204441|Rhodospirillales	204441|Rhodospirillales	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TH2_k127_556243_3	42345.XP_008796038.1	2.008e-78	269.0	COG0637@1|root,KOG2914@2759|Eukaryota,37KNJ@33090|Viridiplantae,3G8EX@35493|Streptophyta,3KU0S@4447|Liliopsida	35493|Streptophyta	S	Haloacid dehalogenase-like hydrolase	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009941,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464	-	-	-	-	-	-	-	-	-	-	HAD_2
TH2_k127_5578280_0	1396141.BATP01000022_gene383	1.457e-37	161.0	COG1595@1|root,COG1595@2|Bacteria,46TQ4@74201|Verrucomicrobia,2IVYP@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4
TH2_k127_5592551_6	32057.KB217478_gene2630	3.077e-128	429.0	COG1649@1|root,COG1649@2|Bacteria,1G42C@1117|Cyanobacteria,1HQTX@1161|Nostocales	1117|Cyanobacteria	S	Glycosyl hydrolase-like 10	-	-	-	-	-	-	-	-	-	-	-	-	GHL10
TH2_k127_5592551_1	243233.MCA2082	3.113e-273	849.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,1XESA@135618|Methylococcales	135618|Methylococcales	H	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
TH2_k127_5592551_5	1120973.AQXL01000134_gene1536	3.22e-171	566.0	COG2352@1|root,COG2352@2|Bacteria,1TQB6@1239|Firmicutes,4HCAF@91061|Bacilli,278RF@186823|Alicyclobacillaceae	91061|Bacilli	C	Phosphoenolpyruvate carboxylase	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
TH2_k127_5592551_4	1122223.KB890701_gene2306	3.54e-196	619.0	COG2223@1|root,COG2223@2|Bacteria,1WJJV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Major Facilitator Superfamily	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
TH2_k127_5592551_3	929556.Solca_1998	6.479e-199	628.0	COG2223@1|root,COG2223@2|Bacteria,4NJ57@976|Bacteroidetes	976|Bacteroidetes	P	Transporter	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1,MgtE_N
TH2_k127_5592551_7	290315.Clim_0362	2.523e-66	243.0	COG1290@1|root,COG1290@2|Bacteria,1FD8I@1090|Chlorobi	1090|Chlorobi	C	PFAM Cytochrome b b6	-	-	-	ko:K02635	ko00195,ko01100,map00195,map01100	M00162	-	-	ko00000,ko00001,ko00002,ko00194	-	-	-	Cytochrom_B_C,Cytochrome_B
TH2_k127_5592551_11	298653.Franean1_4343	1.309e-07	64.0	COG2146@1|root,COG2146@2|Bacteria,2IKSY@201174|Actinobacteria,4ETHF@85013|Frankiales	201174|Actinobacteria	P	PFAM Rieske 2Fe-2S	-	-	1.8.5.2	ko:K16937	ko00920,ko01120,map00920,map01120	-	R07177	-	ko00000,ko00001,ko01000	3.D.4.9	-	-	Rieske
TH2_k127_5592551_8	653733.Selin_2440	2.999e-47	186.0	COG2181@1|root,COG2181@2|Bacteria	2|Bacteria	C	nitrate reductase activity	narI	GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006950,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009628,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0036293,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0046906,GO:0048037,GO:0050896,GO:0055114,GO:0070469,GO:0070470,GO:0070482,GO:0071944,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901363,GO:1902494,GO:1990204	1.7.5.1	ko:K00370,ko:K00374,ko:K02575	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00615,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.1.8,5.A.3.1	-	iEC042_1314.EC042_1594,iECABU_c1320.ECABU_c17020,iECUMN_1333.ECUMN_1718,iNJ661.Rv1164,iSF_1195.SF1230,ic_1306.c1897	Nitrate_red_gam
TH2_k127_5592551_10	404589.Anae109_3597	3.107e-13	81.0	COG2180@1|root,COG2180@2|Bacteria	2|Bacteria	C	chaperone-mediated protein complex assembly	narJ	GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057	-	ko:K00373,ko:K17052	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	5.A.3.8	-	iE2348C_1286.E2348C_1350,iECABU_c1320.ECABU_c15020,iECIAI1_1343.ECIAI1_1469,iECO103_1326.ECO103_1331,iECO111_1330.ECO111_1557,iECW_1372.ECW_m1594,iEKO11_1354.EKO11_2354,iLF82_1304.LF82_1462,iNRG857_1313.NRG857_06280,iSSON_1240.SSON_1659,iWFL_1372.ECW_m1594,ic_1306.c1687	Nitrate_red_del
TH2_k127_5592551_2	670487.Ocepr_1422	4.383e-205	654.0	COG1140@1|root,COG1140@2|Bacteria,1WI79@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	TIGRFAM nitrate reductase, beta subunit	-	-	1.7.5.1	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Fer4_11,Nitr_red_bet_C
TH2_k127_5592551_0	1232410.KI421415_gene2947	0.0	1632.0	COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,42P6X@68525|delta/epsilon subdivisions,2WK8U@28221|Deltaproteobacteria,43U3A@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Molybdopterin,Molydop_binding
TH2_k127_5592551_9	670487.Ocepr_1420	4.128e-15	85.0	COG2010@1|root,COG2010@2|Bacteria,1WJ3M@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	PFAM Cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
TH2_k127_5596561_6	1254432.SCE1572_06800	6.421e-44	171.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,42M98@68525|delta/epsilon subdivisions,2WMKB@28221|Deltaproteobacteria,2YXV7@29|Myxococcales	28221|Deltaproteobacteria	L	HTH-like domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve
TH2_k127_5596561_1	29581.BW37_00264	9.379e-145	470.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,2VK7J@28216|Betaproteobacteria,474BV@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
TH2_k127_5596561_0	452637.Oter_1675	2.087e-208	656.0	COG0439@1|root,COG0439@2|Bacteria,46SIE@74201|Verrucomicrobia,3K78R@414999|Opitutae	414999|Opitutae	I	acetyl-CoA carboxylase	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
TH2_k127_5596561_8	497964.CfE428DRAFT_2954	2.378e-40	156.0	COG0511@1|root,COG0511@2|Bacteria,46SXA@74201|Verrucomicrobia	74201|Verrucomicrobia	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
TH2_k127_5596561_2	497964.CfE428DRAFT_4945	4.792e-133	436.0	COG1541@1|root,COG1541@2|Bacteria,46SVW@74201|Verrucomicrobia	74201|Verrucomicrobia	H	AMP-binding enzyme C-terminal domain	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
TH2_k127_5596561_5	497964.CfE428DRAFT_4946	4.243e-50	184.0	2EK8J@1|root,33DYX@2|Bacteria,46VTQ@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5596561_7	497964.CfE428DRAFT_4947	3.586e-41	160.0	COG0824@1|root,COG0824@2|Bacteria,46VXK@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Thioesterase superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
TH2_k127_5596561_4	880071.Fleli_1647	2.089e-56	204.0	COG2949@1|root,COG2949@2|Bacteria,4NNQS@976|Bacteroidetes,47MWP@768503|Cytophagia	976|Bacteroidetes	S	DUF218 domain	sanA	-	-	ko:K03748	-	-	-	-	ko00000	-	-	-	DUF218
TH2_k127_5596561_3	237368.SCABRO_00035	9.498e-125	416.0	COG2204@1|root,COG2204@2|Bacteria,2IXMN@203682|Planctomycetes	203682|Planctomycetes	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH2_k127_5596561_9	557598.LHK_03181	6.46e-24	104.0	COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,2VWDY@28216|Betaproteobacteria,2KRZB@206351|Neisseriales	206351|Neisseriales	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
TH2_k127_5596561_11	1210884.HG799462_gene8240	6.141e-12	78.0	COG1520@1|root,COG1520@2|Bacteria,2IYD4@203682|Planctomycetes	203682|Planctomycetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
TH2_k127_5596561_10	1123508.JH636449_gene7362	1.078e-19	91.0	COG1520@1|root,COG1520@2|Bacteria,2IX2Z@203682|Planctomycetes	203682|Planctomycetes	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
TH2_k127_5622774_1	313628.LNTAR_21285	1.092e-57	205.0	COG1028@1|root,COG1028@2|Bacteria	313628.LNTAR_21285|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5622774_0	1238450.VIBNISOn1_280048	5.67e-77	272.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,1RMNY@1236|Gammaproteobacteria,1XUZV@135623|Vibrionales	135623|Vibrionales	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
TH2_k127_5622774_2	477641.MODMU_3050	1.096e-16	89.0	COG3875@1|root,COG3875@2|Bacteria,2I9JU@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
TH2_k127_5648928_7	247490.KSU1_C0641	5.117e-43	173.0	COG1538@1|root,COG1538@2|Bacteria,2IZ5D@203682|Planctomycetes	203682|Planctomycetes	MU	outer membrane efflux protein	-	-	-	ko:K15725	-	-	-	-	ko00000,ko02000	1.B.17.2.2	-	-	OEP
TH2_k127_5648928_3	382464.ABSI01000015_gene626	2.007e-110	375.0	COG0845@1|root,COG0845@2|Bacteria,46ZJV@74201|Verrucomicrobia,2IVCQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
TH2_k127_5648928_14	1229276.DI53_1311	0.0007338	47.0	COG0399@1|root,COG0399@2|Bacteria,4PKRF@976|Bacteroidetes	976|Bacteroidetes	M	ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
TH2_k127_5648928_0	886293.Sinac_2096	0.0	1155.0	COG3696@1|root,COG3696@2|Bacteria,2IYCN@203682|Planctomycetes	203682|Planctomycetes	P	AcrB/AcrD/AcrF family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
TH2_k127_5648928_10	1356854.N007_06310	4.265e-24	102.0	COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,4HNJC@91061|Bacilli	91061|Bacilli	K	Cold-Shock Protein	-	-	-	-	-	-	-	-	-	-	-	-	CSD
TH2_k127_5648928_2	497964.CfE428DRAFT_4013	2.896e-169	541.0	COG0513@1|root,COG0513@2|Bacteria,46TUA@74201|Verrucomicrobia	74201|Verrucomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
TH2_k127_5648928_4	452637.Oter_3749	4.838e-80	275.0	COG3267@1|root,COG3267@2|Bacteria,46SXM@74201|Verrucomicrobia,3K91Q@414999|Opitutae	414999|Opitutae	U	Pfam:Arch_ATPase	-	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22
TH2_k127_5648928_11	314230.DSM3645_23071	2.167e-11	68.0	COG2331@1|root,COG2331@2|Bacteria,2J18U@203682|Planctomycetes	203682|Planctomycetes	S	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
TH2_k127_5648928_8	478741.JAFS01000001_gene1426	3.898e-40	154.0	COG2062@1|root,COG2062@2|Bacteria,46TAR@74201|Verrucomicrobia,37GVC@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	T	Phosphoglycerate mutase family	-	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
TH2_k127_5648928_1	452637.Oter_1301	4.92e-188	595.0	COG4806@1|root,COG4806@2|Bacteria,46TUS@74201|Verrucomicrobia,3K7FN@414999|Opitutae	414999|Opitutae	G	L-rhamnose isomerase (RhaA)	rhaA	-	5.3.1.14	ko:K01813	ko00051,ko01120,map00051,map01120	-	R02437	RC00434	ko00000,ko00001,ko01000	-	-	-	RhaA
TH2_k127_5648928_5	329726.AM1_0957	1.792e-58	211.0	COG0598@1|root,COG0598@2|Bacteria,1G4WV@1117|Cyanobacteria	1117|Cyanobacteria	P	CorA-like Mg2+ transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	CorA
TH2_k127_5648928_9	941449.dsx2_2029	9.926e-31	126.0	COG0853@1|root,COG0853@2|Bacteria,1RI1B@1224|Proteobacteria,42SBM@68525|delta/epsilon subdivisions,2WQ24@28221|Deltaproteobacteria,2MCHG@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
TH2_k127_5648928_13	1396418.BATQ01000049_gene391	1.082e-09	70.0	COG3026@1|root,COG3026@2|Bacteria,46W95@74201|Verrucomicrobia,2IUUR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
TH2_k127_5648928_6	1232410.KI421426_gene1437	5.284e-52	190.0	arCOG11509@1|root,31KIR@2|Bacteria,1RGVE@1224|Proteobacteria,42T74@68525|delta/epsilon subdivisions,2WPQ8@28221|Deltaproteobacteria,43UQJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5648928_12	1499967.BAYZ01000153_gene1551	4.954e-10	60.0	COG2373@1|root,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,A2M_recep,CarboxypepD_reg,Plug,Thiol-ester_cl
TH2_k127_5650392_3	926569.ANT_11120	3.99e-63	219.0	COG4813@1|root,COG4813@2|Bacteria,2G5QZ@200795|Chloroflexi	200795|Chloroflexi	G	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	ThuA
TH2_k127_5650392_5	382464.ABSI01000017_gene96	2.342e-41	165.0	COG0662@1|root,COG2207@1|root,COG0662@2|Bacteria,COG2207@2|Bacteria	2|Bacteria	K	Transcriptional regulator	hpaA	-	-	ko:K02099,ko:K02508,ko:K07506,ko:K18954	-	-	-	-	ko00000,ko03000	-	-	-	AraC_binding,Cupin_2,HTH_18
TH2_k127_5650392_2	926569.ANT_15830	1.005e-113	376.0	COG1087@1|root,COG1087@2|Bacteria,2GA96@200795|Chloroflexi	200795|Chloroflexi	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
TH2_k127_5650392_0	237368.SCABRO_02952	6.17e-290	909.0	COG3808@1|root,COG3808@2|Bacteria,2IXUH@203682|Planctomycetes	203682|Planctomycetes	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K01507,ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
TH2_k127_5650392_1	756272.Plabr_1392	6.638e-237	752.0	COG0449@1|root,COG0449@2|Bacteria,2IXF9@203682|Planctomycetes	203682|Planctomycetes	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
TH2_k127_5650392_6	886293.Sinac_3783	3.011e-30	134.0	28IKQ@1|root,2Z8MC@2|Bacteria,2IXYY@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane
TH2_k127_5650392_8	1123508.JH636441_gene3735	2.561e-12	70.0	28IKQ@1|root,2Z8MC@2|Bacteria,2IXYY@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane
TH2_k127_5650392_4	1123508.JH636441_gene3734	1.31e-53	192.0	COG1131@1|root,COG1131@2|Bacteria,2IY1H@203682|Planctomycetes	203682|Planctomycetes	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TH2_k127_5650392_7	485913.Krac_6011	7.381e-24	117.0	COG3039@1|root,COG3039@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
TH2_k127_5654594_17	395493.BegalDRAFT_1262	3.404e-15	80.0	COG5316@1|root,COG5316@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
TH2_k127_5654594_9	338963.Pcar_2629	9.606e-55	200.0	COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,42QZ3@68525|delta/epsilon subdivisions,2WN3V@28221|Deltaproteobacteria,43UAP@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TH2_k127_5654594_14	391625.PPSIR1_28303	5.816e-37	159.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,43CFM@68525|delta/epsilon subdivisions,2X7QN@28221|Deltaproteobacteria,2YZ34@29|Myxococcales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TH2_k127_5654594_1	383372.Rcas_0519	1.109e-145	479.0	COG3525@1|root,COG3525@2|Bacteria,2G609@200795|Chloroflexi,376QW@32061|Chloroflexia	32061|Chloroflexia	G	Glycoside hydrolase, family 20	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_20,Glyco_hydro_20b
TH2_k127_5654594_16	1307761.L21SP2_3409	1.446e-23	110.0	COG1762@1|root,COG1762@2|Bacteria,2J5KE@203691|Spirochaetes	203691|Spirochaetes	G	DNA-binding protein PTS system, IIA component	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	HTH_17,PTS_EIIA_2
TH2_k127_5654594_3	868864.Dester_0551	4.402e-120	404.0	COG0113@1|root,COG0113@2|Bacteria,2G3MJ@200783|Aquificae	200783|Aquificae	H	Belongs to the ALAD family	hemB	GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
TH2_k127_5654594_11	1403819.BATR01000104_gene3624	9.681e-46	182.0	COG3568@1|root,COG3568@2|Bacteria,46Z38@74201|Verrucomicrobia,2IUCM@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TH2_k127_5654594_15	352165.HMPREF7215_0335	8.656e-36	150.0	COG0795@1|root,COG0795@2|Bacteria,3TAEU@508458|Synergistetes	508458|Synergistetes	S	Permease, YjgP YjgQ family	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
TH2_k127_5654594_6	1173020.Cha6605_2376	1.43e-68	239.0	COG2135@1|root,COG2135@2|Bacteria,1G1SA@1117|Cyanobacteria	1117|Cyanobacteria	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
TH2_k127_5654594_10	794903.OPIT5_16315	4.247e-48	177.0	COG1327@1|root,COG1327@2|Bacteria,46VCN@74201|Verrucomicrobia,3K7XU@414999|Opitutae	414999|Opitutae	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
TH2_k127_5654594_13	1229172.JQFA01000002_gene4697	6.624e-43	159.0	COG0537@1|root,COG0537@2|Bacteria,1G6R2@1117|Cyanobacteria,1HBGW@1150|Oscillatoriales	1117|Cyanobacteria	FG	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family	hit	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
TH2_k127_5654594_4	1254432.SCE1572_38850	2.811e-82	292.0	COG0564@1|root,COG1092@1|root,COG0564@2|Bacteria,COG1092@2|Bacteria,1PUHQ@1224|Proteobacteria,42Q87@68525|delta/epsilon subdivisions,2WPIN@28221|Deltaproteobacteria,2Z02J@29|Myxococcales	28221|Deltaproteobacteria	J	Belongs to the methyltransferase superfamily	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,PseudoU_synth_2
TH2_k127_5654594_7	1396141.BATP01000028_gene2352	2.263e-65	227.0	COG1225@1|root,COG1225@2|Bacteria,46V63@74201|Verrucomicrobia,2IWQI@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TH2_k127_5654594_0	583355.Caka_0206	5.986e-164	527.0	COG0641@1|root,COG0641@2|Bacteria,46TC0@74201|Verrucomicrobia	74201|Verrucomicrobia	C	radical SAM	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	-
TH2_k127_5654594_5	886293.Sinac_0844	1.504e-78	280.0	COG1122@1|root,COG1122@2|Bacteria,2IZ47@203682|Planctomycetes	203682|Planctomycetes	P	Part of an ABC transporter complex. Responsible for energy coupling to the transport system	-	-	-	ko:K02006,ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
TH2_k127_5654594_8	886293.Sinac_0846	1.903e-62	231.0	COG0310@1|root,COG0310@2|Bacteria,2IZTS@203682|Planctomycetes	203682|Planctomycetes	P	PFAM cobalamin (vitamin B12) biosynthesis CbiM protein	-	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM,PDGLE
TH2_k127_5654594_12	411464.DESPIG_01530	4.88e-44	164.0	COG0864@1|root,COG0864@2|Bacteria,1RK4R@1224|Proteobacteria,42SID@68525|delta/epsilon subdivisions,2WQ86@28221|Deltaproteobacteria,2MBEU@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	Transcriptional regulator	nikR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
TH2_k127_5654594_19	471852.Tcur_1186	1.386e-06	58.0	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,4EFVQ@85012|Streptosporangiales	201174|Actinobacteria	O	Trypsin-like peptidase domain	sprI	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
TH2_k127_5654594_2	935948.KE386495_gene1019	2.638e-136	460.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,42EQF@68295|Thermoanaerobacterales	186801|Clostridia	P	Heavy metal transport detoxification protein	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
TH2_k127_5655427_9	767817.Desgi_2074	5.577e-08	54.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,1TQNH@1239|Firmicutes,2487I@186801|Clostridia,2602S@186807|Peptococcaceae	186801|Clostridia	H	Belongs to the precorrin methyltransferase family	cobA	-	1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4	ko:K02302,ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03165,R03194,R03947	RC00003,RC00871,RC01012,RC01034,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS15755	HEM4,Porphobil_deam,Porphobil_deamC,TP_methylase
TH2_k127_5655427_6	1049564.TevJSym_ax00210	7.329e-37	147.0	COG2716@1|root,COG2716@2|Bacteria,1R7W7@1224|Proteobacteria,1RSDP@1236|Gammaproteobacteria,1JBWT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	ACT domain	gcvR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576	-	ko:K03567	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	ACT,ACT_6
TH2_k127_5655427_2	429009.Adeg_1744	4.202e-100	336.0	COG0648@1|root,COG0648@2|Bacteria,1TP1D@1239|Firmicutes,2499E@186801|Clostridia,42GGT@68295|Thermoanaerobacterales	186801|Clostridia	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
TH2_k127_5655427_1	1033743.CAES01000013_gene2479	8.082e-176	576.0	COG0436@1|root,COG0436@2|Bacteria,1TQD6@1239|Firmicutes,4HAHQ@91061|Bacilli,26QSS@186822|Paenibacillaceae	91061|Bacilli	E	Produces methionine from 2-keto-4-methylthiobutyrate and glutamine in vitro	dapL	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TH2_k127_5655427_5	1121428.DESHY_160090___1	7.613e-51	191.0	COG2859@1|root,COG2859@2|Bacteria,1V1Q4@1239|Firmicutes,24GEE@186801|Clostridia,264GJ@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF541)	-	-	-	ko:K09797	-	-	-	-	ko00000	-	-	-	SIMPL
TH2_k127_5655427_3	338969.Rfer_4379	7.679e-57	205.0	COG1948@1|root,COG1948@2|Bacteria,1N91Q@1224|Proteobacteria	1224|Proteobacteria	L	ERCC4 domain	-	-	-	-	-	-	-	-	-	-	-	-	ERCC4
TH2_k127_5655427_8	1123070.KB899257_gene2279	1.463e-13	83.0	2BMC5@1|root,32FWC@2|Bacteria,46VBN@74201|Verrucomicrobia,2IVVT@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5655427_0	1382304.JNIL01000001_gene2865	1.199e-180	581.0	COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,4H9ZF@91061|Bacilli,278ZG@186823|Alicyclobacillaceae	91061|Bacilli	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
TH2_k127_5655427_7	1121428.DESHY_50131___1	1.802e-36	141.0	COG3118@1|root,COG3118@2|Bacteria,1VA3Y@1239|Firmicutes,24MM5@186801|Clostridia,262C4@186807|Peptococcaceae	186801|Clostridia	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
TH2_k127_5655436_7	439235.Dalk_2288	1.258e-27	125.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,42R71@68525|delta/epsilon subdivisions,2WMW5@28221|Deltaproteobacteria,2MPW6@213118|Desulfobacterales	28221|Deltaproteobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF4150,RHS,RHS_repeat,Transglut_core
TH2_k127_5655436_10	1536769.P40081_27865	0.0003617	44.0	COG3507@1|root,COG3507@2|Bacteria,1TP5K@1239|Firmicutes,4HCT0@91061|Bacilli,27496@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the glycosyl hydrolase 43 family	-	-	3.2.1.37,3.2.1.55	ko:K01198,ko:K01209	ko00520,ko01100,map00520,map01100	-	R01433,R01762	RC00467	ko00000,ko00001,ko01000	-	GH43,GH51	-	Glyco_hydro_43
TH2_k127_5655436_0	395495.Lcho_3323	3.004e-252	790.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,2VHW5@28216|Betaproteobacteria,1KN4Y@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Alpha amylase catalytic region	-	-	3.2.1.1,3.2.1.10,3.2.1.20,3.2.1.93,5.4.99.16	ko:K01182,ko:K01187,ko:K01226,ko:K05343	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R00837,R01557,R01718,R01791,R02108,R02112,R06087,R06088,R06113,R06199,R11262	RC00028,RC00049,RC00059,RC00077,RC00451,RC01816	ko00000,ko00001,ko01000	-	GH13,GH31	-	Alpha-amylase,Malt_amylase_C
TH2_k127_5655436_4	1163409.UUA_00245	1.213e-108	380.0	COG0591@1|root,COG0591@2|Bacteria,1R4VK@1224|Proteobacteria,1RQFS@1236|Gammaproteobacteria,1X3T5@135614|Xanthomonadales	135614|Xanthomonadales	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
TH2_k127_5655436_9	180332.JTGN01000005_gene2852	1.77e-06	62.0	COG1196@1|root,COG2340@1|root,COG5492@1|root,COG1196@2|Bacteria,COG2340@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	CAP,DUF4114,DUF4842,LRR_5
TH2_k127_5655436_6	478741.JAFS01000001_gene1563	1.883e-54	195.0	COG1522@1|root,COG1522@2|Bacteria,46VEI@74201|Verrucomicrobia,37GSF@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
TH2_k127_5655436_8	1111069.TCCBUS3UF1_22560	2.404e-12	78.0	COG1555@1|root,COG1555@2|Bacteria,1WK8Y@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	DNA uptake protein and related DNA-binding	-	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
TH2_k127_5655436_5	497964.CfE428DRAFT_2041	4.084e-85	309.0	COG1452@1|root,COG1452@2|Bacteria,46SJX@74201|Verrucomicrobia	74201|Verrucomicrobia	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	imp	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA_C
TH2_k127_5655436_1	1403819.BATR01000114_gene3967	2.534e-182	579.0	COG1004@1|root,COG1004@2|Bacteria,46S6E@74201|Verrucomicrobia,2IU1R@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	UDP binding domain	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
TH2_k127_5655436_3	1499967.BAYZ01000074_gene2083	5.204e-113	377.0	COG0451@1|root,COG0451@2|Bacteria,2NNNX@2323|unclassified Bacteria	2|Bacteria	GM	NAD(P)H-binding	wbpP	-	5.1.3.2,5.1.3.7	ko:K01784,ko:K02473	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R00418,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
TH2_k127_5655436_2	497964.CfE428DRAFT_4701	1.522e-127	417.0	COG0482@1|root,COG0482@2|Bacteria,46SQW@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
TH2_k127_5665481_6	1121405.dsmv_1927	1.18e-113	372.0	COG1121@1|root,COG1121@2|Bacteria,1MW47@1224|Proteobacteria,42RR1@68525|delta/epsilon subdivisions,2X5EI@28221|Deltaproteobacteria,2MMSH@213118|Desulfobacterales	28221|Deltaproteobacteria	P	ABC transporter	-	-	-	ko:K09820,ko:K11710	ko02010,map02010	M00243,M00319	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15	-	-	ABC_tran
TH2_k127_5665481_2	344747.PM8797T_06862	2.176e-131	433.0	COG1108@1|root,COG1321@1|root,COG1108@2|Bacteria,COG1321@2|Bacteria,2IY19@203682|Planctomycetes	203682|Planctomycetes	P	COG1108 ABC-type Mn2 Zn2 transport systems permease	-	-	-	ko:K11708	ko02010,map02010	M00319	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15	-	-	ABC-3,Fe_dep_repr_C
TH2_k127_5665481_3	1121405.dsmv_1925	3.251e-128	423.0	COG1108@1|root,COG1321@1|root,COG1108@2|Bacteria,COG1321@2|Bacteria,1MVC2@1224|Proteobacteria,42U9W@68525|delta/epsilon subdivisions,2WTMH@28221|Deltaproteobacteria,2MN3Q@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Iron dependent repressor, metal binding and dimerisation domain	-	-	-	ko:K09819,ko:K11709	ko02010,map02010	M00243,M00319	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15	-	-	ABC-3,Fe_dep_repr_C
TH2_k127_5665481_16	568816.Acin_2163	3.485e-07	62.0	COG0568@1|root,COG0568@2|Bacteria,1TPD6@1239|Firmicutes,4H25A@909932|Negativicutes	909932|Negativicutes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TH2_k127_5665481_10	574375.BAGA_13890	2.66e-61	224.0	COG0667@1|root,COG0667@2|Bacteria,1TPIY@1239|Firmicutes,4HA4Q@91061|Bacilli,1ZCES@1386|Bacillus	91061|Bacilli	C	Aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TH2_k127_5665481_0	497964.CfE428DRAFT_3146	3.723e-239	755.0	COG0028@1|root,COG0028@2|Bacteria,46S72@74201|Verrucomicrobia	74201|Verrucomicrobia	EH	thiamine pyrophosphate protein TPP binding domain protein	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TH2_k127_5665481_5	945713.IALB_2115	2.266e-121	395.0	COG0207@1|root,COG0207@2|Bacteria	2|Bacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	GO:0000287,GO:0003674,GO:0003824,GO:0004799,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006231,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009125,GO:0009129,GO:0009130,GO:0009131,GO:0009157,GO:0009159,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009178,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009314,GO:0009394,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0032259,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042083,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046073,GO:0046078,GO:0046079,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2827,iAPECO1_1312.APECO1_3678,iBWG_1329.BWG_2562,iE2348C_1286.E2348C_3096,iEC042_1314.EC042_3024,iEC55989_1330.EC55989_3103,iECABU_c1320.ECABU_c31240,iECDH10B_1368.ECDH10B_2997,iECDH1ME8569_1439.ECDH1ME8569_2734,iECED1_1282.ECED1_3283,iECH74115_1262.ECH74115_4093,iECIAI1_1343.ECIAI1_2935,iECIAI39_1322.ECIAI39_3246,iECNA114_1301.ECNA114_2885,iECO103_1326.ECO103_3386,iECO111_1330.ECO111_3555,iECO26_1355.ECO26_3899,iECOK1_1307.ECOK1_3231,iECP_1309.ECP_2840,iECS88_1305.ECS88_3122,iECSE_1348.ECSE_3084,iECSF_1327.ECSF_2642,iECSP_1301.ECSP_3779,iECUMN_1333.ECUMN_3154,iECW_1372.ECW_m3069,iECs_1301.ECs3684,iEKO11_1354.EKO11_0914,iETEC_1333.ETEC_3014,iEcDH1_1363.EcDH1_0864,iEcE24377_1341.EcE24377A_3147,iEcSMS35_1347.EcSMS35_2974,iG2583_1286.G2583_3481,iJO1366.b2827,iJR904.b2827,iLF82_1304.LF82_2267,iNRG857_1313.NRG857_13965,iSSON_1240.SSON_2984,iUMN146_1321.UM146_02290,iUMNK88_1353.UMNK88_3511,iUTI89_1310.UTI89_C3229,iWFL_1372.ECW_m3069,iY75_1357.Y75_RS14705,iYL1228.KPN_03236,iZ_1308.Z4144,ic_1306.c3422	Thymidylat_synt
TH2_k127_5665481_11	1123277.KB893195_gene5638	7.56e-43	169.0	COG0262@1|root,COG0262@2|Bacteria,4NQ2Y@976|Bacteroidetes,47Q9G@768503|Cytophagia	976|Bacteroidetes	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	folA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	2TM,DHFR_1
TH2_k127_5665481_14	224325.AF_0939	1.093e-16	91.0	COG1234@1|root,arCOG00501@2157|Archaea,2XTJ9@28890|Euryarchaeota,245Q7@183980|Archaeoglobi	183980|Archaeoglobi	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
TH2_k127_5665481_8	497964.CfE428DRAFT_5163	7.422e-89	314.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
TH2_k127_5665481_15	195522.BD01_0464	1.275e-11	79.0	COG0466@1|root,COG1372@1|root,arCOG02160@2157|Archaea,arCOG03158@2157|Archaea,2Y2YB@28890|Euryarchaeota,242YP@183968|Thermococci	183968|Thermococci	O	Belongs to the peptidase S16 family	-	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C,Mg_chelatase
TH2_k127_5665481_12	1108045.GORHZ_109_00020	9.569e-33	135.0	COG3464@1|root,COG3464@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	UPF0236
TH2_k127_5665481_1	452637.Oter_2576	2.823e-146	476.0	COG0764@1|root,COG0774@1|root,COG0764@2|Bacteria,COG0774@2|Bacteria,46SG1@74201|Verrucomicrobia,3K7GH@414999|Opitutae	414999|Opitutae	IM	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	fabZ	-	3.5.1.108,4.2.1.59	ko:K16363	ko00061,ko00540,ko01100,ko01212,map00061,map00540,map01100,map01212	M00060,M00083	R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965	RC00166,RC00300,RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004,ko01005	-	-	-	FabA,LpxC
TH2_k127_5665481_7	497964.CfE428DRAFT_4114	3.843e-91	316.0	COG1043@1|root,COG1043@2|Bacteria,46SD4@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
TH2_k127_5665481_4	497964.CfE428DRAFT_0213	2.742e-127	422.0	COG1158@1|root,COG1158@2|Bacteria,46UQY@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	-	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_RNA_bind
TH2_k127_5665481_9	1089550.ATTH01000002_gene32	2.268e-85	288.0	COG0670@1|root,COG0670@2|Bacteria,4NFZ7@976|Bacteroidetes	976|Bacteroidetes	S	Belongs to the BI1 family	-	-	-	ko:K06890	-	-	-	-	ko00000	-	-	-	Bax1-I
TH2_k127_5665481_13	313628.LNTAR_09229	1.23e-27	125.0	COG0627@1|root,COG0627@2|Bacteria	2|Bacteria	J	Serine hydrolase involved in the detoxification of formaldehyde	-	-	-	-	-	-	-	-	-	-	-	-	Esterase,Hepar_II_III,Hepar_II_III_N,OprD
TH2_k127_5668968_1	497964.CfE428DRAFT_0232	1.866e-114	388.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5668968_0	518766.Rmar_0138	3.262e-168	542.0	COG0168@1|root,COG0168@2|Bacteria,4NF7R@976|Bacteroidetes,1FIT8@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	Cation transport protein	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
TH2_k127_5668968_3	518766.Rmar_0139	8.897e-74	254.0	COG0569@1|root,COG0569@2|Bacteria,4NGRQ@976|Bacteroidetes,1FJ8V@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	TrkA-N domain	ktrA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
TH2_k127_5668968_2	1203611.KB894543_gene1819	2.335e-95	330.0	COG1032@1|root,COG1032@2|Bacteria,4NKFV@976|Bacteroidetes	976|Bacteroidetes	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
TH2_k127_5668968_4	196162.Noca_1516	4.477e-15	78.0	COG0210@1|root,COG0210@2|Bacteria,2GKRW@201174|Actinobacteria,4DNWV@85009|Propionibacteriales	201174|Actinobacteria	L	HRDC domain	uvrD2	GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0006996,GO:0008094,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0040007,GO:0042623,GO:0043167,GO:0043169,GO:0046872,GO:0051276,GO:0071103,GO:0071840,GO:0140097	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HRDC,UvrD-helicase,UvrD_C
TH2_k127_5687422_3	865937.Gilli_0558	3.073e-120	409.0	COG1520@1|root,COG2304@1|root,COG3391@1|root,COG1520@2|Bacteria,COG2304@2|Bacteria,COG3391@2|Bacteria,4PKD0@976|Bacteroidetes,1HWKJ@117743|Flavobacteriia,2P5SV@244698|Gillisia	976|Bacteroidetes	U	C-terminal domain of CHU protein family	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,HYR,LRR_adjacent
TH2_k127_5687422_0	497964.CfE428DRAFT_2672	5.527e-193	616.0	COG0043@1|root,COG0043@2|Bacteria,46TYE@74201|Verrucomicrobia	74201|Verrucomicrobia	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
TH2_k127_5687422_5	760568.Desku_0383	5.032e-15	83.0	COG2204@1|root,COG2204@2|Bacteria,1V6R9@1239|Firmicutes,24IX3@186801|Clostridia	186801|Clostridia	T	response regulator receiver	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Response_reg,SpoIIE,TPR_11,TPR_8
TH2_k127_5687422_2	247490.KSU1_D0083	2.768e-135	439.0	COG0451@1|root,COG0451@2|Bacteria,2IYBF@203682|Planctomycetes	203682|Planctomycetes	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction	fcl	-	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R05692	RC01014	ko00000,ko00001,ko01000	-	-	-	Epimerase
TH2_k127_5687422_1	926569.ANT_09960	5.403e-177	561.0	COG1089@1|root,COG1089@2|Bacteria,2G5P2@200795|Chloroflexi	200795|Chloroflexi	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
TH2_k127_5687422_4	656519.Halsa_2316	4.678e-19	100.0	COG2801@1|root,COG2801@2|Bacteria,1TT8V@1239|Firmicutes,24BFH@186801|Clostridia	186801|Clostridia	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_29,HTH_32,rve
TH2_k127_5696851_12	240016.ABIZ01000001_gene1662	5.464e-36	141.0	COG0457@1|root,COG1450@1|root,COG0457@2|Bacteria,COG1450@2|Bacteria,46TXY@74201|Verrucomicrobia,2ITGX@203494|Verrucomicrobiae	203494|Verrucomicrobiae	NU	Bacterial type II and III secretion system protein	-	-	-	-	-	-	-	-	-	-	-	-	Secretin
TH2_k127_5696851_11	497964.CfE428DRAFT_5028	1.829e-43	164.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K06075,ko:K22296	-	-	-	-	ko00000,ko03000	-	-	-	MarR,MarR_2
TH2_k127_5696851_1	1403819.BATR01000181_gene6057	6.341e-215	692.0	COG1520@1|root,COG1520@2|Bacteria,46UUP@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
TH2_k127_5696851_3	497964.CfE428DRAFT_5031	1.29e-190	613.0	COG1520@1|root,COG1520@2|Bacteria,46U89@74201|Verrucomicrobia	2|Bacteria	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
TH2_k127_5696851_15	756272.Plabr_2308	2.794e-08	61.0	2EJH6@1|root,33D83@2|Bacteria,2J1HK@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF3311)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3311
TH2_k127_5696851_7	314230.DSM3645_18936	6.609e-100	344.0	COG0591@1|root,COG0591@2|Bacteria,2IY5N@203682|Planctomycetes	203682|Planctomycetes	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
TH2_k127_5696851_2	497964.CfE428DRAFT_5033	1.176e-198	629.0	COG1541@1|root,COG1541@2|Bacteria,46UFN@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5696851_0	497964.CfE428DRAFT_5035	1.693e-222	701.0	COG1012@1|root,COG1012@2|Bacteria,46UJM@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
TH2_k127_5696851_10	314287.GB2207_00675	1.314e-47	181.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria,1J4ZD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008425,GO:0008757,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016741,GO:0030580,GO:0032259,GO:0042180,GO:0042181,GO:0043333,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b3833,iBWG_1329.BWG_3511,iE2348C_1286.E2348C_4147,iEC042_1314.EC042_4213,iEC55989_1330.EC55989_4310,iECDH10B_1368.ECDH10B_4024,iECDH1ME8569_1439.ECDH1ME8569_3712,iECH74115_1262.ECH74115_5274,iECIAI1_1343.ECIAI1_4028,iECIAI39_1322.ECIAI39_3162,iECO103_1326.ECO103_4330,iECO111_1330.ECO111_4661,iECO26_1355.ECO26_4752,iECSE_1348.ECSE_4121,iECSP_1301.ECSP_4888,iECUMN_1333.ECUMN_4359,iECW_1372.ECW_m4135,iECs_1301.ECs4763,iEKO11_1354.EKO11_4524,iETEC_1333.ETEC_4110,iEcDH1_1363.EcDH1_4146,iEcE24377_1341.EcE24377A_4354,iEcHS_1320.EcHS_A4057,iEcSMS35_1347.EcSMS35_4216,iEcolC_1368.EcolC_4175,iG2583_1286.G2583_4633,iJO1366.b3833,iJR904.b3833,iSBO_1134.SBO_3847,iSDY_1059.SDY_3910,iSFV_1184.SFV_3665,iSF_1195.SF3911,iSFxv_1172.SFxv_4263,iSSON_1240.SSON_4008,iS_1188.S3843,iSbBS512_1146.SbBS512_E4305,iUMNK88_1353.UMNK88_4663,iWFL_1372.ECW_m4135,iY75_1357.Y75_RS17910,iZ_1308.Z5355	Ubie_methyltran
TH2_k127_5696851_4	1123508.JH636444_gene5476	1.672e-188	608.0	COG5316@1|root,COG5316@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
TH2_k127_5696851_13	1120705.FG95_00964	1.737e-13	82.0	COG3356@1|root,COG3356@2|Bacteria,1R4RH@1224|Proteobacteria,2U1KB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Neutral alkaline nonlysosomal ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
TH2_k127_5696851_14	756272.Plabr_3394	7.11e-10	71.0	29X2I@1|root,30IR0@2|Bacteria,2J0YA@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1573)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1573
TH2_k127_5696851_9	365046.Rta_22750	2.775e-52	201.0	COG1012@1|root,COG1012@2|Bacteria,1R656@1224|Proteobacteria,2VPB8@28216|Betaproteobacteria,4ACVM@80864|Comamonadaceae	28216|Betaproteobacteria	C	Acyl-CoA reductase (LuxC)	-	-	-	-	-	-	-	-	-	-	-	-	LuxC
TH2_k127_5696851_8	316274.Haur_0795	2.188e-76	269.0	COG0318@1|root,COG0318@2|Bacteria	2|Bacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,LuxE
TH2_k127_5696851_5	56780.SYN_02930	1.287e-187	607.0	COG0480@1|root,COG0480@2|Bacteria,1R0V4@1224|Proteobacteria,42M1F@68525|delta/epsilon subdivisions,2WIYM@28221|Deltaproteobacteria,2MR6X@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Elongation factor Tu domain 2	fusA-1	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
TH2_k127_5696851_6	497964.CfE428DRAFT_1797	3.772e-157	513.0	COG0008@1|root,COG0008@2|Bacteria,46SJ3@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
TH2_k127_5696851_16	382464.ABSI01000013_gene1951	0.0005809	42.0	COG1943@1|root,COG1943@2|Bacteria,46V2P@74201|Verrucomicrobia,2IVVU@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
TH2_k127_5717187_18	405948.SACE_5674	1.602e-56	203.0	COG0508@1|root,COG0508@2|Bacteria,2GN5J@201174|Actinobacteria,4E13H@85010|Pseudonocardiales	201174|Actinobacteria	C	acetyltransferase component of pyruvate dehydrogenase complex	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TH2_k127_5717187_6	696281.Desru_3401	6.281e-109	369.0	COG1249@1|root,COG1249@2|Bacteria,1TP1W@1239|Firmicutes,249R3@186801|Clostridia,260ZD@186807|Peptococcaceae	186801|Clostridia	C	pyridine nucleotide-disulphide oxidoreductase dimerisation	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
TH2_k127_5717187_26	395493.BegalDRAFT_0013	1.938e-13	73.0	COG0061@1|root,COG0061@2|Bacteria,1NBI3@1224|Proteobacteria,1RZ58@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5717187_20	438753.AZC_3547	1.436e-38	160.0	COG1196@1|root,COG3266@1|root,COG1196@2|Bacteria,COG3266@2|Bacteria,1QYJ8@1224|Proteobacteria	1224|Proteobacteria	D	nuclear chromosome segregation	fimV_2	-	-	-	-	-	-	-	-	-	-	-	FecR
TH2_k127_5717187_10	697281.Mahau_0984	2.793e-87	297.0	COG0223@1|root,COG0223@2|Bacteria,1TQ32@1239|Firmicutes,248ED@186801|Clostridia,42FC6@68295|Thermoanaerobacterales	186801|Clostridia	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
TH2_k127_5717187_16	497964.CfE428DRAFT_1669	8.357e-59	211.0	COG0563@1|root,COG0563@2|Bacteria,46SW4@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK
TH2_k127_5717187_1	497964.CfE428DRAFT_4707	9.422e-155	496.0	COG1060@1|root,COG1060@2|Bacteria	2|Bacteria	H	7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity	mqnC	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188	1.21.98.1,2.5.1.77	ko:K11779,ko:K11780,ko:K11781,ko:K11784	ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120	M00378	R08588,R09396	RC01381,RC02329,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
TH2_k127_5717187_19	478741.JAFS01000002_gene320	4.976e-44	171.0	COG1427@1|root,COG1427@2|Bacteria,46VTU@74201|Verrucomicrobia,37GM0@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnA	-	4.2.1.151	ko:K11782	ko00130,ko01110,map00130,map01110	-	R10666	RC03232	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
TH2_k127_5717187_5	575540.Isop_1895	5.84e-126	415.0	COG1060@1|root,COG1060@2|Bacteria,2IXUS@203682|Planctomycetes	203682|Planctomycetes	H	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate	mqnE	-	2.5.1.120	ko:K18285	ko00130,ko01110,map00130,map01110	-	R10667	RC00021,RC03234	ko00000,ko00001,ko01000	-	-	-	Fer4_14,Radical_SAM
TH2_k127_5717187_11	1232410.KI421424_gene1823	6.426e-75	261.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,42MXH@68525|delta/epsilon subdivisions,2WK8E@28221|Deltaproteobacteria,43S3V@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	UbiA prenyltransferase family	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
TH2_k127_5717187_3	237368.SCABRO_00224	2.834e-132	439.0	COG1524@1|root,COG1524@2|Bacteria,2IXT6@203682|Planctomycetes	203682|Planctomycetes	S	PFAM type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
TH2_k127_5717187_21	1121929.KB898662_gene411	2.808e-30	129.0	COG0382@1|root,COG0382@2|Bacteria,1UZUK@1239|Firmicutes,4HDQ2@91061|Bacilli	91061|Bacilli	H	UbiA prenyltransferase family	-	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
TH2_k127_5717187_30	111781.Lepto7376_1452	9.774e-06	58.0	COG4254@1|root,COG4254@2|Bacteria,1G662@1117|Cyanobacteria,1HA7R@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
TH2_k127_5717187_14	643648.Slip_0866	3.433e-60	233.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,42JMD@68298|Syntrophomonadaceae	186801|Clostridia	KLT	Protein kinase domain	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
TH2_k127_5717187_29	1265507.KB899637_gene490	1.712e-07	53.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RN4X@1236|Gammaproteobacteria,1Y3E2@135624|Aeromonadales	135624|Aeromonadales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topB	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
TH2_k127_5717187_15	382464.ABSI01000011_gene3091	2.872e-59	216.0	COG1344@1|root,COG1344@2|Bacteria,46UKJ@74201|Verrucomicrobia	74201|Verrucomicrobia	N	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella	-	-	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
TH2_k127_5717187_4	886293.Sinac_7402	1.743e-127	432.0	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG3850@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,COG3850@2|Bacteria,2IXFD@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg
TH2_k127_5717187_17	497964.CfE428DRAFT_2286	2.161e-57	207.0	COG0745@1|root,COG0745@2|Bacteria	497964.CfE428DRAFT_2286|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5717187_0	1156937.MFUM_720018	1.011e-224	719.0	COG0112@1|root,COG0112@2|Bacteria,46S5I@74201|Verrucomicrobia,37G4S@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	LMWPc,LacAB_rpiB,SHMT
TH2_k127_5717187_24	195253.Syn6312_0279	5.563e-14	84.0	COG0793@1|root,COG0793@2|Bacteria,1GBZP@1117|Cyanobacteria	1117|Cyanobacteria	M	tail specific protease	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,Peptidase_S41
TH2_k127_5717187_2	1125863.JAFN01000001_gene568	7.894e-153	497.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,42MCI@68525|delta/epsilon subdivisions,2WJ7H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC,GARS_A,GARS_C,GARS_N
TH2_k127_5717187_8	649638.Trad_1843	7.086e-108	362.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,PmoA
TH2_k127_5717187_28	1211819.CALK01000020_gene828	2.056e-10	72.0	COG1082@1|root,COG1082@2|Bacteria,1V329@1239|Firmicutes	1239|Firmicutes	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TH2_k127_5717187_27	762982.HMPREF9442_02521	1.125e-11	77.0	COG0627@1|root,COG0627@2|Bacteria,4NHCB@976|Bacteroidetes,2FR49@200643|Bacteroidia	976|Bacteroidetes	S	Serine hydrolase involved in the detoxification of formaldehyde	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5717187_25	452637.Oter_2910	1.145e-13	81.0	2DN7B@1|root,32VXX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5717187_7	665956.HMPREF1032_00855	6.356e-109	362.0	COG0407@1|root,COG0407@2|Bacteria,1UY51@1239|Firmicutes,24E75@186801|Clostridia,3WPCX@541000|Ruminococcaceae	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
TH2_k127_5717187_9	929713.NIASO_15075	1.761e-90	305.0	COG5285@1|root,COG5285@2|Bacteria,4NJ09@976|Bacteroidetes,1IQAS@117747|Sphingobacteriia	976|Bacteroidetes	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
TH2_k127_5717187_22	794903.OPIT5_26835	5.187e-25	116.0	COG1917@1|root,COG4977@1|root,COG1917@2|Bacteria,COG4977@2|Bacteria,46WEY@74201|Verrucomicrobia,3K92Z@414999|Opitutae	414999|Opitutae	K	Transcriptional regulator	-	-	-	ko:K02854	-	-	-	-	ko00000,ko03000	-	-	-	AraC_binding,HTH_18,PAS_4
TH2_k127_5717187_12	497964.CfE428DRAFT_1836	3.486e-71	253.0	COG2755@1|root,COG2755@2|Bacteria,46TA7@74201|Verrucomicrobia	74201|Verrucomicrobia	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	GxDLY,Lipase_GDSL_3
TH2_k127_5717187_13	661478.OP10G_1065	2.428e-69	251.0	COG3934@1|root,COG3934@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	3.2.1.78	ko:K19355	ko00051,map00051	-	R01332	RC00467	ko00000,ko00001,ko01000	-	-	-	Cellulase,DUF5060
TH2_k127_5717187_23	96561.Dole_1809	1.621e-22	109.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
TH2_k127_5731935_5	926692.AZYG01000064_gene967	1.802e-51	194.0	COG3735@1|root,COG3735@2|Bacteria,1V7NU@1239|Firmicutes,24IJ8@186801|Clostridia	186801|Clostridia	S	TraB family	-	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
TH2_k127_5731935_2	497964.CfE428DRAFT_1506	1.512e-153	496.0	COG0766@1|root,COG0766@2|Bacteria,46S6Q@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
TH2_k127_5731935_4	497964.CfE428DRAFT_1505	5.424e-66	238.0	COG2890@1|root,COG2890@2|Bacteria,46SZE@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_25,Methyltransf_31
TH2_k127_5731935_9	309799.DICTH_1450	7.942e-18	88.0	COG0071@1|root,COG0071@2|Bacteria	2|Bacteria	O	Belongs to the small heat shock protein (HSP20) family	MA20_45160	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
TH2_k127_5731935_0	309801.trd_1023	1.367e-260	826.0	COG0466@1|root,COG0466@2|Bacteria,2G5TZ@200795|Chloroflexi,27XY6@189775|Thermomicrobia	189775|Thermomicrobia	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
TH2_k127_5731935_11	1123227.KB899335_gene239	8.137e-09	60.0	COG5336@1|root,COG5336@2|Bacteria	2|Bacteria	C	function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex	atpI	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATPase_gene1
TH2_k127_5731935_6	861299.J421_3947	1.598e-29	127.0	COG0356@1|root,COG0356@2|Bacteria,1ZSQ5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
TH2_k127_5731935_10	105422.BBPM01000002_gene5127	2.04e-11	67.0	COG0636@1|root,COG0636@2|Bacteria,2GQI6@201174|Actinobacteria,2NJQB@228398|Streptacidiphilus	201174|Actinobacteria	C	ATP synthase subunit C	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
TH2_k127_5731935_8	1385514.N782_06165	1.719e-22	107.0	COG0711@1|root,COG0711@2|Bacteria,1VB85@1239|Firmicutes,4HM64@91061|Bacilli,2YA9F@289201|Pontibacillus	91061|Bacilli	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iYO844.BSU36850	ATP-synt_B
TH2_k127_5731935_7	1121430.JMLG01000002_gene1220	3.277e-24	108.0	COG0712@1|root,COG0712@2|Bacteria,1VAG3@1239|Firmicutes,24MSA@186801|Clostridia,261U6@186807|Peptococcaceae	186801|Clostridia	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
TH2_k127_5731935_1	246194.CHY_2547	4.985e-216	681.0	COG0056@1|root,COG0056@2|Bacteria,1TNZ8@1239|Firmicutes,248IY@186801|Clostridia,42F4E@68295|Thermoanaerobacterales	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
TH2_k127_5731935_3	1121423.JONT01000003_gene1048	2.59e-68	241.0	COG0224@1|root,COG0224@2|Bacteria,1TPBX@1239|Firmicutes,2486Q@186801|Clostridia,2601T@186807|Peptococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
TH2_k127_5741504_5	452637.Oter_3368	1.627e-60	214.0	COG0147@1|root,COG0147@2|Bacteria,46S4I@74201|Verrucomicrobia,3K72I@414999|Opitutae	414999|Opitutae	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
TH2_k127_5741504_8	1303518.CCALI_01623	9.053e-41	155.0	COG0139@1|root,COG0139@2|Bacteria	2|Bacteria	E	phosphoribosyl-AMP cyclohydrolase activity	hisI	GO:0000105,GO:0003674,GO:0003824,GO:0004635,GO:0004636,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.5.4.19,3.5.4.25,3.6.1.31,5.3.1.16	ko:K01496,ko:K01497,ko:K01814,ko:K11755	ko00340,ko00740,ko00790,ko01100,ko01110,ko01230,ko02024,map00340,map00740,map00790,map01100,map01110,map01230,map02024	M00026,M00125	R00425,R04035,R04037,R04640	RC00002,RC00293,RC00945,RC01055,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.ECNA114_0880,iECW_1372.ECW_m2186,iEKO11_1354.EKO11_1768,iHN637.CLJU_RS05760,iSB619.SA_RS14110,iUMN146_1321.UM146_06665,iWFL_1372.ECW_m2186	His_biosynth,PRA-CH,PRA-PH
TH2_k127_5741504_0	639282.DEFDS_1905	4.014e-113	370.0	COG0107@1|root,COG0107@2|Bacteria,2GENM@200930|Deferribacteres	200930|Deferribacteres	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TH2_k127_5741504_7	497964.CfE428DRAFT_0734	2.007e-45	169.0	COG0817@1|root,COG0817@2|Bacteria,46T3Y@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
TH2_k127_5741504_11	765913.ThidrDRAFT_4684	8.05e-16	80.0	2CD2E@1|root,330VS@2|Bacteria,1N86R@1224|Proteobacteria,1SE64@1236|Gammaproteobacteria,1X1FA@135613|Chromatiales	135613|Chromatiales	S	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
TH2_k127_5741504_6	631362.Thi970DRAFT_03118	1.173e-51	188.0	COG1848@1|root,COG1848@2|Bacteria,1N3CQ@1224|Proteobacteria,1S919@1236|Gammaproteobacteria,1WYY3@135613|Chromatiales	135613|Chromatiales	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TH2_k127_5741504_3	589865.DaAHT2_1209	9.68e-84	287.0	COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,42N7Q@68525|delta/epsilon subdivisions,2WJ1I@28221|Deltaproteobacteria,2MIE0@213118|Desulfobacterales	28221|Deltaproteobacteria	K	transcriptional regulatory protein	yebC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
TH2_k127_5741504_1	240016.ABIZ01000001_gene1539	2.888e-111	376.0	COG1520@1|root,COG1520@2|Bacteria,46TV4@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
TH2_k127_5741504_2	673860.AciM339_1573	1.218e-107	361.0	COG0182@1|root,arCOG01123@2157|Archaea,2Y86P@28890|Euryarchaeota,3F36H@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	-	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.23	ko:K03239,ko:K08963	ko00270,ko01100,ko03013,map00270,map01100,map03013	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000,ko03012	-	-	-	IF-2B
TH2_k127_5741504_10	1541065.JRFE01000001_gene2556	1.297e-17	91.0	COG0235@1|root,COG0235@2|Bacteria,1G59N@1117|Cyanobacteria,3VMQZ@52604|Pleurocapsales	1117|Cyanobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
TH2_k127_5741504_9	880072.Desac_2224	4.062e-23	107.0	COG1011@1|root,COG1011@2|Bacteria,1Q6A1@1224|Proteobacteria,43F2Y@68525|delta/epsilon subdivisions,2X36J@28221|Deltaproteobacteria,2MS5Y@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	3.1.3.10	ko:K20866	ko00010,ko01120,map00010,map01120	-	R00947	RC00078	ko00000,ko00001,ko01000	-	-	-	HAD_2
TH2_k127_5741504_4	1123242.JH636435_gene2613	4.4e-65	231.0	COG1595@1|root,COG1595@2|Bacteria,2IZZP@203682|Planctomycetes	203682|Planctomycetes	K	Sigma-70 region 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
TH2_k127_5778693_2	497964.CfE428DRAFT_6117	3.387e-40	156.0	COG0558@1|root,COG0558@2|Bacteria,46VZY@74201|Verrucomicrobia	74201|Verrucomicrobia	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TH2_k127_5778693_3	344747.PM8797T_23881	4.053e-25	110.0	COG1267@1|root,COG1267@2|Bacteria	2|Bacteria	I	phosphatidylglycerophosphatase activity	pgpA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008962,GO:0009058,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0030258,GO:0031224,GO:0031226,GO:0032026,GO:0042221,GO:0042577,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0046839,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901576	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	iECSP_1301.ECSP_0485,iECUMN_1333.ECUMN_0456,iECs_1301.ECs0471,iG2583_1286.G2583_0529,iPC815.YPO3179,iZ_1308.Z0520	PgpA
TH2_k127_5778693_1	1379698.RBG1_1C00001G0988	3.267e-77	292.0	COG1413@1|root,COG1413@2|Bacteria,2NQWQ@2323|unclassified Bacteria	2|Bacteria	C	lyase activity	-	-	3.4.24.3	ko:K01387,ko:K03301	-	-	-	-	ko00000,ko01000,ko01002,ko02042	2.A.12	-	-	DUF1822,DUF4132,HEAT_2,HEAT_PBS,Peptidase_M9,Peptidase_M9_N,Sulfatase
TH2_k127_5778693_0	861299.J421_3883	1.278e-243	762.0	COG1429@1|root,COG1429@2|Bacteria	2|Bacteria	H	ligase activity, forming nitrogen-metal bonds	cobN	-	6.6.1.2	ko:K02230	ko00860,ko01100,map00860,map01100	-	R05227	RC02000	ko00000,ko00001,ko01000	-	-	-	CobN-Mg_chel,Glyco_hydro_63
TH2_k127_5778760_4	1463879.JOHP01000095_gene4266	2.296e-07	59.0	COG0739@1|root,COG1652@1|root,COG0739@2|Bacteria,COG1652@2|Bacteria,2GK68@201174|Actinobacteria	201174|Actinobacteria	M	domain protein	-	-	-	ko:K21687	-	-	-	-	ko00000	-	GH23	-	LysM,Peptidase_M23,Transglycosylas
TH2_k127_5778760_0	497964.CfE428DRAFT_0899	5.613e-130	425.0	COG0820@1|root,COG0820@2|Bacteria,46SBD@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
TH2_k127_5778760_2	290397.Adeh_2370	2.855e-66	236.0	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,42QXV@68525|delta/epsilon subdivisions,2WMXB@28221|Deltaproteobacteria,2YUZZ@29|Myxococcales	28221|Deltaproteobacteria	L	Uracil-DNA glycosylase	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TH2_k127_5778760_1	59538.XP_005983093.1	8.471e-86	304.0	COG0564@1|root,KOG1919@2759|Eukaryota,3A0ZH@33154|Opisthokonta,3BPWB@33208|Metazoa,3DBUF@33213|Bilateria	33208|Metazoa	A	RNA pseudouridylate synthase	-	-	-	-	-	-	-	-	-	-	-	-	PseudoU_synth_2,S4
TH2_k127_5778760_3	439235.Dalk_1768	9.402e-57	206.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,42M2I@68525|delta/epsilon subdivisions,2WNPT@28221|Deltaproteobacteria,2MIZH@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
TH2_k127_5810991_2	945713.IALB_2814	2.768e-104	346.0	COG5557@1|root,COG5557@2|Bacteria	2|Bacteria	C	Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
TH2_k127_5810991_1	945713.IALB_2815	1.84e-136	445.0	COG0437@1|root,COG0437@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	-	-	-	ko:K00184,ko:K08358	ko00920,ko01120,ko02020,map00920,map01120,map02020	-	R10150	RC03109	ko00000,ko00001,ko02000	5.A.3,5.A.3.10	-	-	Fer4_11,Fer4_4,Fer4_7,Ferredoxin_N
TH2_k127_5810991_4	1163617.SCD_n02825	4.57e-30	135.0	COG3746@1|root,COG3746@2|Bacteria,1MV8P@1224|Proteobacteria,2VNJT@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Putative porin	-	-	-	-	-	-	-	-	-	-	-	-	Porin_5
TH2_k127_5810991_3	452637.Oter_4074	1.528e-34	144.0	COG2169@1|root,COG4936@1|root,COG2169@2|Bacteria,COG4936@2|Bacteria,46UZR@74201|Verrucomicrobia,3K795@414999|Opitutae	414999|Opitutae	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,PocR
TH2_k127_5810991_5	338963.Pcar_0493	1.986e-09	68.0	2BCS0@1|root,300MS@2|Bacteria,1RFA2@1224|Proteobacteria,42SAB@68525|delta/epsilon subdivisions,2WNVK@28221|Deltaproteobacteria,43SGY@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Bacterial protein of unknown function (Gcw_chp)	-	-	-	-	-	-	-	-	-	-	-	-	Gcw_chp
TH2_k127_5810991_0	452637.Oter_2476	7.352e-177	563.0	COG0004@1|root,COG0004@2|Bacteria,46SCE@74201|Verrucomicrobia,3K7NK@414999|Opitutae	414999|Opitutae	P	ammonium transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
TH2_k127_5812213_0	452637.Oter_3674	3.763e-186	591.0	COG0008@1|root,COG0008@2|Bacteria,46S4X@74201|Verrucomicrobia,3K7DH@414999|Opitutae	414999|Opitutae	J	glutaminyl-tRNA synthetase	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
TH2_k127_5812213_1	247490.KSU1_D0782	3.516e-129	429.0	COG3170@1|root,COG3170@2|Bacteria,2J3MN@203682|Planctomycetes	203682|Planctomycetes	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5812213_2	247490.KSU1_D0783	1.093e-73	258.0	COG0803@1|root,COG0803@2|Bacteria,2J0IP@203682|Planctomycetes	203682|Planctomycetes	P	Zinc-uptake complex component A periplasmic	-	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
TH2_k127_5812213_3	1403819.BATR01000098_gene3225	1.834e-61	216.0	COG1595@1|root,COG1595@2|Bacteria,46WAZ@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TH2_k127_5812213_4	697282.Mettu_3431	9.814e-46	170.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1XEHC@135618|Methylococcales	135618|Methylococcales	P	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	E1-E2_ATPase,Hydrolase
TH2_k127_5825963_2	1541065.JRFE01000016_gene508	2.834e-94	317.0	COG3829@1|root,COG4251@1|root,COG3829@2|Bacteria,COG4251@2|Bacteria,1G1Z5@1117|Cyanobacteria,3VJIW@52604|Pleurocapsales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,GAF,HATPase_c,HisKA,PAS_3,PAS_4,Response_reg
TH2_k127_5825963_4	1232437.KL662050_gene5354	3.614e-61	217.0	COG0784@1|root,COG0784@2|Bacteria,1QUN7@1224|Proteobacteria,42T9C@68525|delta/epsilon subdivisions,2WP3Z@28221|Deltaproteobacteria,2MKTX@213118|Desulfobacterales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TH2_k127_5825963_1	880073.Calab_1764	1.201e-153	513.0	COG4191@1|root,COG4191@2|Bacteria,2NP93@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TH2_k127_5825963_6	583355.Caka_2819	5.427e-51	186.0	COG0663@1|root,COG0663@2|Bacteria,46V13@74201|Verrucomicrobia,3K82W@414999|Opitutae	414999|Opitutae	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
TH2_k127_5825963_3	1382359.JIAL01000001_gene24	1.116e-84	292.0	COG0009@1|root,COG0009@2|Bacteria,3Y3VW@57723|Acidobacteria,2JHTT@204432|Acidobacteriia	204432|Acidobacteriia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
TH2_k127_5825963_5	1249480.B649_07640	2.833e-51	188.0	COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,42RV5@68525|delta/epsilon subdivisions,2YP89@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
TH2_k127_5825963_0	671143.DAMO_1057	8.349e-177	589.0	COG1391@1|root,COG1391@2|Bacteria	2|Bacteria	H	[glutamate-ammonia-ligase] adenylyltransferase activity	glnE	GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
TH2_k127_5832981_18	483219.LILAB_10430	3.321e-16	91.0	COG1520@1|root,COG5184@1|root,COG1520@2|Bacteria,COG5184@2|Bacteria,1R504@1224|Proteobacteria,42QHC@68525|delta/epsilon subdivisions,2WKUI@28221|Deltaproteobacteria,2YY0K@29|Myxococcales	28221|Deltaproteobacteria	DZ	Putative metal-binding motif	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE,RCC1
TH2_k127_5832981_7	1185876.BN8_01058	2.412e-63	234.0	COG4733@1|root,COG4733@2|Bacteria,4NK2V@976|Bacteroidetes,47P6C@768503|Cytophagia	976|Bacteroidetes	G	PFAM Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	fn3
TH2_k127_5832981_9	497964.CfE428DRAFT_5221	1.803e-42	160.0	COG2402@1|root,COG2402@2|Bacteria,46WKX@74201|Verrucomicrobia	2|Bacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TH2_k127_5832981_0	1396141.BATP01000012_gene2704	6.004e-224	702.0	COG1904@1|root,COG1904@2|Bacteria,46SH8@74201|Verrucomicrobia,2ITWJ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Glucuronate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	UxaC
TH2_k127_5832981_19	1123508.JH636447_gene7850	1.654e-11	64.0	COG0639@1|root,COG4639@1|root,COG0639@2|Bacteria,COG4639@2|Bacteria,2IXM8@203682|Planctomycetes	203682|Planctomycetes	T	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33,Metallophos,PNKP-ligase_C,PNKP_ligase
TH2_k127_5832981_5	497964.CfE428DRAFT_1981	2.606e-81	287.0	COG1397@1|root,COG1397@2|Bacteria	2|Bacteria	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
TH2_k127_5832981_14	1210884.HG799465_gene11759	4.822e-27	126.0	2BRR1@1|root,32KQS@2|Bacteria,2J4RN@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5832981_1	240016.ABIZ01000001_gene1053	1.455e-150	484.0	COG0451@1|root,COG0451@2|Bacteria,46S80@74201|Verrucomicrobia,2ITWW@203494|Verrucomicrobiae	203494|Verrucomicrobiae	GM	GDP-mannose 4,6 dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	GDP_Man_Dehyd
TH2_k127_5832981_17	742740.HMPREF9474_00249	5.951e-19	100.0	COG0673@1|root,COG1063@1|root,COG0673@2|Bacteria,COG1063@2|Bacteria,1TP4D@1239|Firmicutes	1239|Firmicutes	E	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,GFO_IDH_MocA
TH2_k127_5832981_16	1266998.ATUJ01000011_gene2460	1.559e-20	107.0	COG1082@1|root,COG1082@2|Bacteria,1MUU8@1224|Proteobacteria,2U2GX@28211|Alphaproteobacteria,2PXQK@265|Paracoccus	28211|Alphaproteobacteria	G	Xylose isomerase-like TIM barrel	-	-	4.2.1.118	ko:K15652	ko00400,ko01110,ko01130,map00400,map01110,map01130	-	R01627	RC00568	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
TH2_k127_5832981_13	1033743.CAES01000041_gene85	2.093e-30	133.0	COG0111@1|root,COG0111@2|Bacteria,1U2XG@1239|Firmicutes,4HF1I@91061|Bacilli,26TFB@186822|Paenibacillaceae	91061|Bacilli	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TH2_k127_5832981_3	1123288.SOV_1c07780	4.671e-113	386.0	COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,4H6Y8@909932|Negativicutes	909932|Negativicutes	EH	Anthranilate synthase component I, N terminal region	-	-	2.6.1.85	ko:K01665	ko00790,map00790	-	R01716	RC00010,RC01418	ko00000,ko00001,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
TH2_k127_5832981_10	1123288.SOV_1c07790	1.124e-41	164.0	COG0115@1|root,COG0115@2|Bacteria,1TPY2@1239|Firmicutes,4H92Y@909932|Negativicutes	909932|Negativicutes	EH	Amino-transferase class IV	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_4
TH2_k127_5832981_12	56780.SYN_00581	7.627e-34	136.0	COG1186@1|root,COG1186@2|Bacteria,1NBAD@1224|Proteobacteria,42UTT@68525|delta/epsilon subdivisions,2WQZK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	PFAM Class I peptide chain release factor	-	-	-	-	-	-	-	-	-	-	-	-	RF-1
TH2_k127_5832981_15	1396418.BATQ01000050_gene303	2.731e-25	111.0	COG0782@1|root,COG0782@2|Bacteria,46T65@74201|Verrucomicrobia,2IUVV@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5832981_8	452637.Oter_0798	5.483e-53	200.0	COG0741@1|root,COG0741@2|Bacteria,46XU1@74201|Verrucomicrobia,3K83P@414999|Opitutae	414999|Opitutae	M	Transglycosylase SLT domain	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	SLT
TH2_k127_5832981_4	138119.DSY3222	1.213e-88	300.0	COG0689@1|root,COG0689@2|Bacteria,1TQM3@1239|Firmicutes,25E5P@186801|Clostridia,26123@186807|Peptococcaceae	186801|Clostridia	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56,3.6.1.66	ko:K00989,ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03016	-	-	-	Ham1p_like,RNase_PH,RNase_PH_C
TH2_k127_5832981_11	56780.SYN_02029	9.373e-37	146.0	COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,42TMM@68525|delta/epsilon subdivisions,2WQ6S@28221|Deltaproteobacteria,2MS94@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	LigT like Phosphoesterase	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
TH2_k127_5832981_2	382464.ABSI01000012_gene2267	1.657e-135	443.0	COG0468@1|root,COG0468@2|Bacteria,46SIZ@74201|Verrucomicrobia,2ITWB@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
TH2_k127_5832981_6	697281.Mahau_0748	4.698e-81	278.0	COG1691@1|root,COG1691@2|Bacteria,1TP0Z@1239|Firmicutes,24815@186801|Clostridia,42FCC@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
TH2_k127_5836970_2	1121423.JONT01000001_gene1919	4.078e-60	218.0	COG2003@1|root,COG2003@2|Bacteria,1TQ3K@1239|Firmicutes,2498Z@186801|Clostridia,25ZZS@186807|Peptococcaceae	186801|Clostridia	E	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
TH2_k127_5836970_4	335543.Sfum_3764	7.328e-41	158.0	COG1388@1|root,COG3023@1|root,COG1388@2|Bacteria,COG3023@2|Bacteria,1NQ5P@1224|Proteobacteria,43AMU@68525|delta/epsilon subdivisions,2X61Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2
TH2_k127_5836970_0	555088.DealDRAFT_0478	9.235e-121	402.0	COG2262@1|root,COG2262@2|Bacteria,1TNZB@1239|Firmicutes,248IU@186801|Clostridia,42K9Q@68298|Syntrophomonadaceae	186801|Clostridia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
TH2_k127_5836970_1	398767.Glov_0992	5.471e-70	252.0	COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,42M7V@68525|delta/epsilon subdivisions,2WIUB@28221|Deltaproteobacteria,43U4M@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
TH2_k127_5836970_6	401473.BDP_0552	3.408e-12	72.0	COG0801@1|root,COG1539@1|root,COG0801@2|Bacteria,COG1539@2|Bacteria,2H3G6@201174|Actinobacteria,4D0EJ@85004|Bifidobacteriales	201174|Actinobacteria	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folK	-	2.7.6.3,4.1.2.25	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R03504	RC00002,RC00017,RC00721,RC00943	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB,HPPK
TH2_k127_5836970_3	1396141.BATP01000060_gene4695	5.08e-41	163.0	COG0546@1|root,COG1051@1|root,COG0546@2|Bacteria,COG1051@2|Bacteria,46VY5@74201|Verrucomicrobia,2IUEQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	F	HAD-hyrolase-like	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2,NUDIX
TH2_k127_5836970_7	642492.Clole_3491	3.041e-08	64.0	COG0705@1|root,COG0705@2|Bacteria,1TSBP@1239|Firmicutes,249D8@186801|Clostridia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
TH2_k127_5836970_5	278957.ABEA03000046_gene1614	6.181e-31	133.0	COG1994@1|root,COG1994@2|Bacteria,46VEB@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50,Peptidase_M50B
TH2_k127_5839207_0	1123508.JH636441_gene3129	4.782e-222	698.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,2IYRX@203682|Planctomycetes	203682|Planctomycetes	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
TH2_k127_5839207_2	1123508.JH636441_gene3128	5.791e-104	351.0	COG0508@1|root,COG0508@2|Bacteria,2IXCU@203682|Planctomycetes	203682|Planctomycetes	C	e3 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TH2_k127_5839207_1	344747.PM8797T_07549	4.435e-111	365.0	COG5285@1|root,COG5285@2|Bacteria,2IXDT@203682|Planctomycetes	203682|Planctomycetes	Q	COG5285 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
TH2_k127_5839207_3	1123242.JH636434_gene3402	8.89e-11	67.0	COG5285@1|root,COG5285@2|Bacteria,2IXDT@203682|Planctomycetes	203682|Planctomycetes	Q	COG5285 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
TH2_k127_5870793_3	1121015.N789_11925	1.685e-55	220.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,1RSKR@1236|Gammaproteobacteria,1XCCR@135614|Xanthomonadales	135614|Xanthomonadales	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
TH2_k127_5870793_2	1304885.AUEY01000021_gene3454	2.244e-83	290.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,42MNJ@68525|delta/epsilon subdivisions,2WIZZ@28221|Deltaproteobacteria,2MI8E@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Protein of unknown function (DUF933)	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
TH2_k127_5870793_0	497964.CfE428DRAFT_2463	3.749e-163	523.0	COG0436@1|root,COG0436@2|Bacteria,46S4M@74201|Verrucomicrobia	74201|Verrucomicrobia	E	aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TH2_k127_5870793_1	1156937.MFUM_1080005	7.669e-132	431.0	COG0105@1|root,COG0105@2|Bacteria,46T8K@74201|Verrucomicrobia,37G1K@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	F	Nucleoside diphosphate kinase	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
TH2_k127_5870793_6	1459636.NTE_03059	3.344e-13	72.0	arCOG07442@1|root,arCOG07442@2157|Archaea,41SWG@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5870793_4	686340.Metal_3625	1.864e-51	185.0	arCOG14922@1|root,32SW8@2|Bacteria,1N0NY@1224|Proteobacteria,1S5XN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Copper resistance protein D	-	-	-	-	-	-	-	-	-	-	-	-	CopD
TH2_k127_5870793_5	452637.Oter_1417	4.565e-48	192.0	COG0795@1|root,COG0795@2|Bacteria,46STR@74201|Verrucomicrobia,3K762@414999|Opitutae	414999|Opitutae	S	Predicted permease YjgP/YjgQ family	-	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
TH2_k127_5878840_4	765911.Thivi_0827	5.066e-19	91.0	COG1061@1|root,COG1061@2|Bacteria,1MV9F@1224|Proteobacteria,1T58S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	helicase superfamily c-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,ResIII
TH2_k127_5878840_0	530564.Psta_3549	1.62e-255	807.0	COG0855@1|root,COG0855@2|Bacteria,2IWVK@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
TH2_k127_5878840_1	1123242.JH636435_gene2856	1.92e-152	499.0	COG0248@1|root,COG0248@2|Bacteria,2IYSV@203682|Planctomycetes	203682|Planctomycetes	FP	Ppx GppA phosphatase	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,Ppx-GppA
TH2_k127_5878840_2	521674.Plim_2404	1.385e-107	358.0	COG1940@1|root,COG1940@2|Bacteria,2IY6I@203682|Planctomycetes	203682|Planctomycetes	GK	PFAM ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
TH2_k127_5878840_3	278957.ABEA03000166_gene4031	2.385e-44	167.0	COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,46V5M@74201|Verrucomicrobia,3K9Z9@414999|Opitutae	414999|Opitutae	K	PFAM helix-turn-helix- domain containing protein AraC type	-	-	-	ko:K02855	-	-	-	-	ko00000,ko03000	-	-	-	HTH_18
TH2_k127_5913306_2	330214.NIDE1753	1.357e-33	130.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TH2_k127_5913306_3	1410638.JHXJ01000003_gene1551	1.183e-21	111.0	COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,248M4@186801|Clostridia,3WH66@541000|Ruminococcaceae	186801|Clostridia	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
TH2_k127_5913306_0	886293.Sinac_3283	1.373e-146	477.0	COG0624@1|root,COG0624@2|Bacteria,2IXPJ@203682|Planctomycetes	203682|Planctomycetes	E	ArgE DapE Acy1 family protein	-	-	3.5.1.16,3.5.1.18	ko:K01438,ko:K01439	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00669,R02734,R09107	RC00064,RC00090,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
TH2_k127_5913306_4	313628.LNTAR_12106	3.235e-11	68.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_1,PG_binding_1,Peptidase_S8,RHS_repeat
TH2_k127_5913306_1	313628.LNTAR_12106	2.844e-51	200.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_1,PG_binding_1,Peptidase_S8,RHS_repeat
TH2_k127_5984360_3	880073.Calab_1318	5.918e-87	297.0	COG0508@1|root,COG0508@2|Bacteria,2NP69@2323|unclassified Bacteria	2|Bacteria	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	aceF	GO:0003674,GO:0003824,GO:0004742,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016407,GO:0016417,GO:0016418,GO:0016740,GO:0016746,GO:0016747,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030523,GO:0031405,GO:0031406,GO:0032787,GO:0032991,GO:0033293,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1902494,GO:1990204	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iETEC_1333.ETEC_0111,iSSON_1240.SSON_0123,iYL1228.KPN_00119	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TH2_k127_5984360_1	105559.Nwat_1144	2.893e-153	498.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1WWGK@135613|Chromatiales	135613|Chromatiales	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
TH2_k127_5984360_4	452637.Oter_0242	2.305e-42	163.0	COG0811@1|root,COG0811@2|Bacteria,46SUA@74201|Verrucomicrobia,3K7EH@414999|Opitutae	414999|Opitutae	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
TH2_k127_5984360_7	247490.KSU1_C0761	1.304e-11	76.0	COG0848@1|root,COG0848@2|Bacteria,2J0SA@203682|Planctomycetes	203682|Planctomycetes	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
TH2_k127_5984360_0	481448.Minf_0245	5.036e-180	573.0	COG0516@1|root,COG0516@2|Bacteria,46W51@74201|Verrucomicrobia,37FWR@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	F	IMP dehydrogenase / GMP reductase domain	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
TH2_k127_5984360_6	768671.ThimaDRAFT_3025	1.185e-21	100.0	COG2442@1|root,COG2442@2|Bacteria,1P47Y@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
TH2_k127_5984360_5	794903.OPIT5_19320	3.984e-31	128.0	COG4634@1|root,COG4634@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Mut7-C
TH2_k127_5984360_2	497964.CfE428DRAFT_6618	3.732e-121	394.0	COG0519@1|root,COG0519@2|Bacteria,46SIW@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
TH2_k127_5993681_6	456442.Mboo_1527	7.998e-40	155.0	arCOG02349@1|root,arCOG02352@1|root,arCOG02349@2157|Archaea,arCOG02352@2157|Archaea	2157|Archaea	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_2,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
TH2_k127_5993681_3	240016.ABIZ01000001_gene5853	2.861e-57	203.0	COG2258@1|root,COG2258@2|Bacteria,46VBP@74201|Verrucomicrobia,2IUHR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5993681_11	502025.Hoch_4952	1.309e-09	72.0	COG0745@1|root,COG0745@2|Bacteria,1QVDV@1224|Proteobacteria,43APF@68525|delta/epsilon subdivisions,2X631@28221|Deltaproteobacteria,2Z38J@29|Myxococcales	28221|Deltaproteobacteria	T	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388,Response_reg
TH2_k127_5993681_12	1089553.Tph_c08940	1.736e-06	61.0	COG2203@1|root,COG2206@1|root,COG4936@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,COG4936@2|Bacteria,1UZN2@1239|Firmicutes,248SE@186801|Clostridia,42GDE@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM Metal-dependent phosphohydrolase, HD	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HD,PAS_9,PocR
TH2_k127_5993681_2	639282.DEFDS_0625	4.062e-126	417.0	COG2805@1|root,COG2805@2|Bacteria,2GF8B@200930|Deferribacteres	200930|Deferribacteres	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
TH2_k127_5993681_1	497964.CfE428DRAFT_2599	6.355e-134	444.0	COG2204@1|root,COG2204@2|Bacteria,46SDB@74201|Verrucomicrobia	74201|Verrucomicrobia	T	sigma-54 factor interaction domain-containing protein	-	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH2_k127_5993681_0	497964.CfE428DRAFT_3562	3.914e-136	444.0	COG1459@1|root,COG1459@2|Bacteria,46S5B@74201|Verrucomicrobia	74201|Verrucomicrobia	U	PFAM type II secretion system	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
TH2_k127_5993681_4	864069.MicloDRAFT_00059520	1.524e-54	212.0	COG3039@1|root,COG3039@2|Bacteria,1NDMF@1224|Proteobacteria,2UPG2@28211|Alphaproteobacteria,1JUC2@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
TH2_k127_5993681_13	278957.ABEA03000174_gene3430	2.259e-05	49.0	2CFGC@1|root,33FFI@2|Bacteria,46YKF@74201|Verrucomicrobia,3K9S6@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5993681_9	649831.L083_5152	1.465e-18	97.0	COG0673@1|root,COG0673@2|Bacteria,2IFZE@201174|Actinobacteria,4DHQ3@85008|Micromonosporales	201174|Actinobacteria	S	Putative oxidoreductase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C,ox_reductase_C
TH2_k127_5993681_5	573413.Spirs_0413	4.154e-50	191.0	29808@1|root,2ZV6B@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_5993681_7	378806.STAUR_0362	5.968e-31	123.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,42QCN@68525|delta/epsilon subdivisions,2WIYT@28221|Deltaproteobacteria,2YV4K@29|Myxococcales	28221|Deltaproteobacteria	P	Chromate transporter	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
TH2_k127_5993681_8	497964.CfE428DRAFT_5476	4.181e-21	98.0	COG2059@1|root,COG2059@2|Bacteria,46V8S@74201|Verrucomicrobia	74201|Verrucomicrobia	P	Chromate transporter	-	-	-	-	-	-	-	-	-	-	-	-	Chromate_transp
TH2_k127_5993681_10	886379.AEWI01000039_gene2836	1.749e-17	86.0	COG2344@1|root,COG2344@2|Bacteria,4NIIF@976|Bacteroidetes,2FKZF@200643|Bacteroidia,3XJ9F@558415|Marinilabiliaceae	976|Bacteroidetes	K	Putative DNA-binding protein N-terminus	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
TH2_k127_6022996_4	1396141.BATP01000022_gene358	3.736e-86	303.0	COG0737@1|root,COG0737@2|Bacteria,46X8F@74201|Verrucomicrobia,2IV06@203494|Verrucomicrobiae	203494|Verrucomicrobiae	F	Calcineurin-like phosphoesterase	-	-	3.1.3.5	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
TH2_k127_6022996_8	452637.Oter_0400	3.043e-48	181.0	COG1360@1|root,COG1360@2|Bacteria,46VC4@74201|Verrucomicrobia,3K7YD@414999|Opitutae	414999|Opitutae	N	Membrane MotB of proton-channel complex MotA/MotB	-	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
TH2_k127_6022996_5	521674.Plim_2583	1.891e-83	290.0	COG1291@1|root,COG1291@2|Bacteria	2|Bacteria	N	archaeal or bacterial-type flagellum-dependent cell motility	motA	GO:0006935,GO:0008150,GO:0009605,GO:0040011,GO:0042221,GO:0042330,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0052116,GO:0052126,GO:0052127,GO:0052143,GO:0052192,GO:0052195,GO:0052216,GO:0052243	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
TH2_k127_6022996_7	794903.OPIT5_24930	3.212e-61	221.0	COG1191@1|root,COG1191@2|Bacteria,46TPW@74201|Verrucomicrobia,3K7F7@414999|Opitutae	414999|Opitutae	K	Sigma-70 region 3	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
TH2_k127_6022996_9	452637.Oter_0404	3.025e-16	91.0	COG1419@1|root,COG1419@2|Bacteria,46VBY@74201|Verrucomicrobia,3K9JP@414999|Opitutae	414999|Opitutae	N	protein localization to endoplasmic reticulum	-	-	-	ko:K02404	-	-	-	-	ko00000,ko02035	-	-	-	-
TH2_k127_6022996_0	278957.ABEA03000202_gene4309	1.886e-233	743.0	COG1298@1|root,COG1298@2|Bacteria,46TTN@74201|Verrucomicrobia,3K7G5@414999|Opitutae	414999|Opitutae	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
TH2_k127_6022996_6	452637.Oter_0406	5.508e-72	259.0	COG1377@1|root,COG1377@2|Bacteria,46U7X@74201|Verrucomicrobia,3K76M@414999|Opitutae	414999|Opitutae	NU	FlhB HrpN YscU SpaS Family	-	-	-	ko:K02401	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_2
TH2_k127_6022996_1	1123393.KB891316_gene1087	7.128e-136	442.0	COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,2VJAD@28216|Betaproteobacteria,1KRJ4@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Male sterility protein	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
TH2_k127_6022996_3	595460.RRSWK_05816	2.206e-92	316.0	COG1091@1|root,COG1091@2|Bacteria	2|Bacteria	M	dTDP-4-dehydrorhamnose reductase activity	rfbD	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
TH2_k127_6022996_2	1122963.AUHB01000001_gene426	5.222e-130	423.0	COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,2TQPI@28211|Alphaproteobacteria,36X9M@31993|Methylocystaceae	28211|Alphaproteobacteria	M	Nucleotidyl transferase	rfbA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TH2_k127_6022996_10	575540.Isop_1525	9.372e-05	53.0	COG4485@1|root,COG4485@2|Bacteria,2J25S@203682|Planctomycetes	203682|Planctomycetes	S	Bacterial membrane protein, YfhO	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6024566_9	1123242.JH636434_gene5399	3.137e-19	102.0	2C10F@1|root,32R7T@2|Bacteria,2IZVB@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6024566_7	525904.Tter_1099	5.301e-60	224.0	COG2856@1|root,COG2856@2|Bacteria,2NQY0@2323|unclassified Bacteria	2|Bacteria	E	Zn peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6024566_1	382464.ABSI01000023_gene546	7.169e-182	593.0	COG0557@1|root,COG0557@2|Bacteria,46U8T@74201|Verrucomicrobia,2ITHQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
TH2_k127_6024566_2	583355.Caka_2931	3.85e-170	555.0	COG0738@1|root,COG0738@2|Bacteria,46TFW@74201|Verrucomicrobia,3K9UU@414999|Opitutae	414999|Opitutae	G	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TH2_k127_6024566_11	1385511.N783_00430	2.866e-08	59.0	28H7K@1|root,2Z7JT@2|Bacteria,1UPH1@1239|Firmicutes,4HE88@91061|Bacilli	91061|Bacilli	P	The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system	kdgT	-	-	ko:K02526	-	-	-	-	ko00000,ko02000	2.A.10.1	-	-	KdgT
TH2_k127_6024566_6	1216976.AX27061_5674	2.076e-60	220.0	COG0451@1|root,COG0451@2|Bacteria,1MU1A@1224|Proteobacteria,2VHGA@28216|Betaproteobacteria,3T1XJ@506|Alcaligenaceae	28216|Betaproteobacteria	M	Male sterility protein	-	-	1.1.1.410	ko:K22025	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
TH2_k127_6024566_12	1382304.JNIL01000001_gene1206	1.88e-07	61.0	COG2768@1|root,COG2768@2|Bacteria,1TPRV@1239|Firmicutes,4HE76@91061|Bacilli	91061|Bacilli	C	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
TH2_k127_6024566_3	1499967.BAYZ01000159_gene495	1.939e-102	349.0	COG2768@1|root,COG2768@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088,DUF362
TH2_k127_6024566_4	158189.SpiBuddy_0057	5.814e-76	271.0	COG0176@1|root,COG0176@2|Bacteria	2|Bacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
TH2_k127_6024566_10	398527.Bphyt_5795	3.237e-11	64.0	COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,2VHJB@28216|Betaproteobacteria,1K0EB@119060|Burkholderiaceae	28216|Betaproteobacteria	G	PFAM D-galactarate dehydratase Altronate hydrolase domain protein	-	-	4.2.1.42,4.2.1.7,4.4.1.24	ko:K01685,ko:K01708,ko:K16846	ko00040,ko00053,ko00270,ko01100,map00040,map00053,map00270,map01100	M00631	R01540,R05608,R07633	RC00543,RC01785	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C,SAF
TH2_k127_6024566_0	1379698.RBG1_1C00001G1725	6.349e-303	961.0	COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria	2|Bacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	acrD	-	-	ko:K03296,ko:K18138,ko:K18307	ko01501,ko01503,ko02024,map01501,map01503,map02024	M00644,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.20,2.A.6.2.32	-	-	ACR_tran
TH2_k127_6024566_5	1502851.FG93_04941	6.293e-68	246.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,2U2CU@28211|Alphaproteobacteria,3JQRQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	MA20_16810	-	-	ko:K03585,ko:K18306	ko01501,ko01503,ko02024,map01501,map01503,map02024	M00644,M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,2.A.6.2.20,2.A.6.2.32,8.A.1,8.A.1.6	-	-	HlyD_D23
TH2_k127_6024566_8	926564.KI911694_gene932	1.714e-29	126.0	COG0248@1|root,COG0248@2|Bacteria,2GJBN@201174|Actinobacteria,4F3BR@85017|Promicromonosporaceae	201174|Actinobacteria	FP	Ppx/GppA phosphatase family	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
TH2_k127_604853_10	497964.CfE428DRAFT_6675	9.558e-13	73.0	COG1544@1|root,COG1544@2|Bacteria,46WN8@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Sigma 54 modulation protein / S30EA ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	Ribosomal_S30AE
TH2_k127_604853_1	240016.ABIZ01000001_gene3005	1.589e-93	313.0	COG2738@1|root,COG2738@2|Bacteria,46TH9@74201|Verrucomicrobia,2IUJW@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K06973	-	-	-	-	ko00000	-	-	-	Zn_peptidase_2
TH2_k127_604853_0	452637.Oter_1440	9.793e-120	391.0	COG0583@1|root,COG0583@2|Bacteria,46TZU@74201|Verrucomicrobia	74201|Verrucomicrobia	K	LysR substrate binding domain	-	-	-	ko:K03717	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
TH2_k127_604853_3	382464.ABSI01000005_gene1229	7.846e-27	119.0	COG0811@1|root,COG0811@2|Bacteria	2|Bacteria	U	bacteriocin transport	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
TH2_k127_604853_9	1500894.JQNN01000001_gene4554	1.899e-13	83.0	2E8A6@1|root,332P2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_604853_11	1201293.AKXQ01000019_gene1167	1.086e-05	54.0	COG0848@1|root,COG0848@2|Bacteria,1RI4M@1224|Proteobacteria	1224|Proteobacteria	U	biopolymer transport protein	exbD	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
TH2_k127_604853_7	448385.sce2660	8.316e-15	89.0	COG1413@1|root,COG1413@2|Bacteria,1N55Z@1224|Proteobacteria,42Q7F@68525|delta/epsilon subdivisions,2WPWV@28221|Deltaproteobacteria,2YU62@29|Myxococcales	28221|Deltaproteobacteria	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT,HEAT_2,HEAT_PBS
TH2_k127_604853_5	118163.Ple7327_1940	4.609e-21	109.0	28N1B@1|root,2ZB7I@2|Bacteria,1G011@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_604853_2	118168.MC7420_1277	1.732e-53	214.0	28N1B@1|root,2ZB7I@2|Bacteria,1G011@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_604853_8	349741.Amuc_1188	4.092e-14	80.0	2EIJD@1|root,33CAP@2|Bacteria,46WH7@74201|Verrucomicrobia,2IW3W@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_604853_4	278963.ATWD01000001_gene2337	1.747e-25	112.0	2AV7S@1|root,31KYE@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_604853_6	278957.ABEA03000176_gene2819	1.366e-18	93.0	COG0583@1|root,COG0583@2|Bacteria,46V82@74201|Verrucomicrobia,3K8TT@414999|Opitutae	414999|Opitutae	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TH2_k127_6051608_1	497964.CfE428DRAFT_2640	3.822e-18	86.0	COG1082@1|root,COG1082@2|Bacteria,46V1E@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
TH2_k127_6051608_3	69042.WH5701_06661	0.0001954	50.0	COG0745@1|root,COG0745@2|Bacteria,1FZXT@1117|Cyanobacteria,1GYSU@1129|Synechococcus	1117|Cyanobacteria	K	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K07669	ko02020,map02020	M00460	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TH2_k127_6051608_0	497964.CfE428DRAFT_4653	6.446e-200	645.0	COG1199@1|root,COG1199@2|Bacteria,46SCS@74201|Verrucomicrobia	74201|Verrucomicrobia	L	SMART helicase c2	dinG	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2,ResIII
TH2_k127_6051608_2	762982.HMPREF9442_02521	1.517e-11	78.0	COG0627@1|root,COG0627@2|Bacteria,4NHCB@976|Bacteroidetes,2FR49@200643|Bacteroidia	976|Bacteroidetes	S	Serine hydrolase involved in the detoxification of formaldehyde	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6055029_1	886293.Sinac_7167	5.451e-40	164.0	COG1595@1|root,COG1596@1|root,COG1595@2|Bacteria,COG1596@2|Bacteria	2|Bacteria	M	polysaccharide export	pslD	-	-	ko:K01991,ko:K03088,ko:K20987	ko02025,ko02026,map02025,map02026	-	-	-	ko00000,ko00001,ko02000,ko03021	1.B.18	-	-	Poly_export,SLBB,Sigma70_r2,Sigma70_r4_2
TH2_k127_6055029_0	1303518.CCALI_00138	3.791e-124	407.0	COG0714@1|root,COG0714@2|Bacteria	2|Bacteria	KLT	Associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TH2_k127_6068665_2	344747.PM8797T_28934	5.785e-17	90.0	2CBS1@1|root,32RTY@2|Bacteria,2J3DR@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6068665_0	497964.CfE428DRAFT_5151	5.501e-126	411.0	COG1840@1|root,COG1840@2|Bacteria	2|Bacteria	P	iron ion homeostasis	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_11,SBP_bac_6,SBP_bac_8
TH2_k127_6068665_1	1123242.JH636434_gene5474	1.003e-93	329.0	COG1196@1|root,COG1196@2|Bacteria,2IYM0@203682|Planctomycetes	203682|Planctomycetes	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_608406_5	1307759.JOMJ01000003_gene1587	6.171e-122	408.0	COG1269@1|root,COG1269@2|Bacteria,1QGFB@1224|Proteobacteria,42QGM@68525|delta/epsilon subdivisions,2WR5N@28221|Deltaproteobacteria,2MA35@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	-
TH2_k127_608406_11	59374.Fisuc_2839	3.548e-61	217.0	COG1394@1|root,COG1394@2|Bacteria	2|Bacteria	C	ATPase activity, coupled to transmembrane movement of substances	atpD	-	-	ko:K02118,ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
TH2_k127_608406_2	1313293.BAN_0105900	5.36e-199	629.0	COG1156@1|root,COG1156@2|Bacteria,2J574@203691|Spirochaetes	203691|Spirochaetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
TH2_k127_608406_1	1307759.JOMJ01000003_gene1584	1.089e-281	875.0	COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,42NKK@68525|delta/epsilon subdivisions,2WIQQ@28221|Deltaproteobacteria,2MAPX@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
TH2_k127_608406_13	1307759.JOMJ01000003_gene1582	7.316e-47	177.0	COG1390@1|root,COG1390@2|Bacteria,1Q7JS@1224|Proteobacteria,42V5M@68525|delta/epsilon subdivisions,2WS1Y@28221|Deltaproteobacteria,2MBK8@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	-	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	-
TH2_k127_608406_6	903818.KI912268_gene1381	1.376e-120	422.0	COG3863@1|root,COG3863@2|Bacteria	2|Bacteria	T	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C92
TH2_k127_608406_4	497964.CfE428DRAFT_5370	1.019e-139	456.0	COG2255@1|root,COG2255@2|Bacteria,46SDS@74201|Verrucomicrobia	74201|Verrucomicrobia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
TH2_k127_608406_16	1396141.BATP01000030_gene3683	5.759e-08	63.0	2FCZ3@1|root,3451R@2|Bacteria,46WBW@74201|Verrucomicrobia,2IUXT@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
TH2_k127_608406_14	349741.Amuc_1416	1.426e-43	167.0	COG0632@1|root,COG0632@2|Bacteria,46SZF@74201|Verrucomicrobia,2IUHG@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
TH2_k127_608406_12	583355.Caka_0688	1.705e-54	213.0	2F6YF@1|root,33PYZ@2|Bacteria,46TE0@74201|Verrucomicrobia,3K7ET@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_608406_10	278957.ABEA03000004_gene4534	3.31e-73	252.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL,Lipase_GDSL_2
TH2_k127_608406_7	926569.ANT_29930	4.767e-96	323.0	COG2116@1|root,COG2116@2|Bacteria,2G967@200795|Chloroflexi	200795|Chloroflexi	P	Formate/nitrite transporter	-	-	-	ko:K06212	-	-	-	-	ko00000,ko02000	1.A.16.1.1,1.A.16.1.3	-	-	Form_Nir_trans
TH2_k127_608406_3	258533.BN977_05832	4.525e-142	465.0	COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria,23D4U@1762|Mycobacteriaceae	201174|Actinobacteria	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
TH2_k127_608406_0	402626.Rpic_4642	2.87e-322	1009.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2VP2Q@28216|Betaproteobacteria,1JZNE@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Formate dehydrogenase alpha subunit	fdsA	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_21,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
TH2_k127_608406_9	266117.Rxyl_0145	9.291e-82	287.0	COG1526@1|root,COG1526@2|Bacteria,2GKWC@201174|Actinobacteria,4CQ2Z@84995|Rubrobacteria	84995|Rubrobacteria	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
TH2_k127_608406_8	926569.ANT_25450	9.215e-93	310.0	COG2896@1|root,COG2896@2|Bacteria,2G5JT@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
TH2_k127_6087013_1	481448.Minf_0381	5.761e-48	180.0	COG2121@1|root,COG2121@2|Bacteria,46SZ0@74201|Verrucomicrobia,37GQD@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function (DUF374)	-	-	-	ko:K09778	-	-	-	-	ko00000	-	-	-	DUF374
TH2_k127_6087013_0	401526.TcarDRAFT_0104	4.324e-138	459.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,4H20M@909932|Negativicutes	909932|Negativicutes	V	lipid A export permease ATP-binding protein MsbA	msbA	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
TH2_k127_6087013_2	756272.Plabr_2435	4.754e-39	166.0	COG1657@1|root,COG1657@2|Bacteria,2IXVT@203682|Planctomycetes	203682|Planctomycetes	I	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159,Prenyltrans
TH2_k127_6122667_1	497964.CfE428DRAFT_4943	1.162e-43	168.0	COG0577@1|root,COG0577@2|Bacteria,46U6N@74201|Verrucomicrobia	74201|Verrucomicrobia	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
TH2_k127_6122667_0	497964.CfE428DRAFT_4944	1.214e-73	255.0	COG1136@1|root,COG1136@2|Bacteria,46V6W@74201|Verrucomicrobia	74201|Verrucomicrobia	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TH2_k127_6137768_0	383372.Rcas_3263	1.268e-98	330.0	COG3329@1|root,COG3329@2|Bacteria,2GAMM@200795|Chloroflexi,376S1@32061|Chloroflexia	32061|Chloroflexia	S	Na+-dependent bicarbonate transporter superfamily	-	-	-	ko:K07086	-	-	-	-	ko00000	-	-	-	Sbt_1
TH2_k127_6137768_1	926560.KE387027_gene550	3.376e-18	92.0	COG0347@1|root,COG0347@2|Bacteria,1WK66@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Belongs to the P(II) protein family	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6137768_2	56780.SYN_00202	7.646e-10	68.0	COG3026@1|root,COG3026@2|Bacteria,1NNWM@1224|Proteobacteria,433CH@68525|delta/epsilon subdivisions,2WX6Q@28221|Deltaproteobacteria,2MSAR@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Domain of unknown function (DUF4412)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4412
TH2_k127_6163183_1	1007105.PT7_0835	4.364e-26	121.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,2VHKP@28216|Betaproteobacteria,3T2JS@506|Alcaligenaceae	28216|Betaproteobacteria	S	Competence protein	comA	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
TH2_k127_6163183_0	278957.ABEA03000019_gene1865	1.588e-34	140.0	2DRPS@1|root,33CHR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2204
TH2_k127_6173542_20	497964.CfE428DRAFT_6672	4.03e-27	112.0	COG0361@1|root,COG0361@2|Bacteria,46T5J@74201|Verrucomicrobia	74201|Verrucomicrobia	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
TH2_k127_6173542_19	497964.CfE428DRAFT_6673	3.928e-29	121.0	COG0724@1|root,COG0724@2|Bacteria,46VMU@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM RNP-1 like RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
TH2_k127_6173542_5	1403819.BATR01000130_gene4600	1.934e-118	392.0	COG1131@1|root,COG1131@2|Bacteria,46UCI@74201|Verrucomicrobia,2IU5T@203494|Verrucomicrobiae	203494|Verrucomicrobiae	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TH2_k127_6173542_11	1121405.dsmv_1084	1.528e-86	293.0	COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,42SH9@68525|delta/epsilon subdivisions,2WPWW@28221|Deltaproteobacteria,2MIHA@213118|Desulfobacterales	28221|Deltaproteobacteria	N	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux
TH2_k127_6173542_10	1121405.dsmv_1085	1.618e-103	360.0	COG3225@1|root,COG3225@2|Bacteria,1MY63@1224|Proteobacteria,42N95@68525|delta/epsilon subdivisions,2WJ0N@28221|Deltaproteobacteria,2MJFD@213118|Desulfobacterales	28221|Deltaproteobacteria	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
TH2_k127_6173542_22	439235.Dalk_1261	7.812e-11	74.0	2AF4E@1|root,31534@2|Bacteria,1NEPN@1224|Proteobacteria,42WGJ@68525|delta/epsilon subdivisions,2WRTJ@28221|Deltaproteobacteria,2MM2R@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
TH2_k127_6173542_23	929713.NIASO_14845	4.838e-07	58.0	2DR4X@1|root,33A68@2|Bacteria	2|Bacteria	S	COG3678 P pilus assembly Cpx signaling pathway, periplasmic inhibitor zinc-resistance associated protein	-	-	-	-	-	-	-	-	-	-	-	-	LTXXQ,Metal_resist
TH2_k127_6173542_8	243164.DET1587	4.267e-107	363.0	COG0501@1|root,COG0501@2|Bacteria,2G6UV@200795|Chloroflexi,34D0W@301297|Dehalococcoidia	301297|Dehalococcoidia	O	Peptidase family M48	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
TH2_k127_6173542_14	386456.JQKN01000015_gene2945	3.08e-65	228.0	COG1704@1|root,arCOG04574@2157|Archaea,2XXB9@28890|Euryarchaeota,23PHV@183925|Methanobacteria	183925|Methanobacteria	S	PFAM LemA	-	-	-	-	-	-	-	-	-	-	-	-	LemA
TH2_k127_6173542_21	945713.IALB_2435	1.001e-18	94.0	COG3809@1|root,COG3809@2|Bacteria	2|Bacteria	S	Transcription factor zinc-finger	-	-	-	ko:K09981	-	-	-	-	ko00000	-	-	-	Rhomboid,zf-TFIIB
TH2_k127_6173542_17	398767.Glov_2434	1.119e-30	128.0	COG0745@1|root,COG0745@2|Bacteria	398767.Glov_2434|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6173542_1	497964.CfE428DRAFT_6231	1.111e-179	585.0	COG0745@1|root,COG5000@1|root,COG0745@2|Bacteria,COG5000@2|Bacteria,46S9G@74201|Verrucomicrobia	74201|Verrucomicrobia	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,Response_reg
TH2_k127_6173542_18	237368.SCABRO_01145	2.226e-29	122.0	COG0745@1|root,COG0745@2|Bacteria,2IY82@203682|Planctomycetes	203682|Planctomycetes	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,Response_reg
TH2_k127_6173542_6	497964.CfE428DRAFT_6230	6.918e-111	386.0	COG0784@1|root,COG2204@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	ko:K01991,ko:K03413	ko02020,ko02026,ko02030,map02020,map02026,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02000,ko02022,ko02035	1.B.18	-	-	GAF_2,HATPase_c,HisKA,PAS_9,Response_reg
TH2_k127_6173542_4	1123508.JH636446_gene6369	2.736e-136	463.0	COG3852@1|root,COG4191@1|root,COG3852@2|Bacteria,COG4191@2|Bacteria,2IWUM@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TH2_k127_6173542_12	1210884.HG799465_gene11482	3.461e-75	258.0	COG0745@1|root,COG0745@2|Bacteria,2J0GS@203682|Planctomycetes	203682|Planctomycetes	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,Response_reg
TH2_k127_6173542_3	886293.Sinac_7544	1.792e-166	557.0	COG0784@1|root,COG2198@1|root,COG2202@1|root,COG2203@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG5002@2|Bacteria,2J4YH@203682|Planctomycetes	203682|Planctomycetes	T	His Kinase A (phosphoacceptor	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS_4,Response_reg
TH2_k127_6173542_2	1403819.BATR01000093_gene2891	1.275e-167	539.0	COG0423@1|root,COG0423@2|Bacteria,46TEV@74201|Verrucomicrobia,2ITMG@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Anticodon binding domain	-	-	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
TH2_k127_6173542_16	163908.KB235896_gene2298	2.074e-42	177.0	COG2931@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,1GJ7F@1117|Cyanobacteria,1HQZ9@1161|Nostocales	1117|Cyanobacteria	QU	Domains in Na-Ca exchangers and integrin-beta4	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta
TH2_k127_6173542_7	478741.JAFS01000001_gene1826	2.864e-108	379.0	COG0304@1|root,COG0304@2|Bacteria,46SBU@74201|Verrucomicrobia,37G4W@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	-	-	-	-	-	-	-	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TH2_k127_6173542_15	478741.JAFS01000001_gene1827	1.149e-47	195.0	2BYFZ@1|root,2ZG3M@2|Bacteria,46T80@74201|Verrucomicrobia	74201|Verrucomicrobia	Q	Beta-ketoacyl synthase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	ketoacyl-synt
TH2_k127_6173542_13	1158760.AQXP01000054_gene1634	1.477e-69	248.0	COG0500@1|root,COG2226@2|Bacteria,1MVXG@1224|Proteobacteria,1S4GS@1236|Gammaproteobacteria,1WY88@135613|Chromatiales	135613|Chromatiales	Q	ubiE/COQ5 methyltransferase family	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
TH2_k127_6173542_0	481448.Minf_1902	2.747e-185	596.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,46TH0@74201|Verrucomicrobia,37G1H@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	L	DNA polymerase X family	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_thumb,HHH_5,HHH_8,PHP
TH2_k127_6173542_9	330214.NIDE2536	2.575e-105	366.0	COG0021@1|root,COG0021@2|Bacteria,3J0MM@40117|Nitrospirae	40117|Nitrospirae	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
TH2_k127_6196062_0	272134.KB731324_gene3585	2.937e-55	198.0	COG0577@1|root,COG0577@2|Bacteria,1G0Z7@1117|Cyanobacteria,1H9BF@1150|Oscillatoriales	1117|Cyanobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TH2_k127_620335_3	452637.Oter_3656	6.021e-26	111.0	COG0145@1|root,COG0145@2|Bacteria,46VJ0@74201|Verrucomicrobia,3K89W@414999|Opitutae	414999|Opitutae	EQ	Protein of unknown function (DUF1638)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1638
TH2_k127_620335_2	1121921.KB898710_gene466	2.579e-51	191.0	COG2207@1|root,COG2207@2|Bacteria,1QVRX@1224|Proteobacteria,1T2IC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2,HTH_18
TH2_k127_620335_0	1120950.KB892778_gene1041	2.107e-141	455.0	COG5285@1|root,COG5285@2|Bacteria,2IJZQ@201174|Actinobacteria	201174|Actinobacteria	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
TH2_k127_620335_1	545695.TREAZ_3490	1.769e-58	223.0	COG5012@1|root,COG5012@2|Bacteria	2|Bacteria	T	cobalamin binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6370156_3	756272.Plabr_2179	2.983e-74	257.0	COG5285@1|root,COG5285@2|Bacteria,2IXYK@203682|Planctomycetes	203682|Planctomycetes	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
TH2_k127_6370156_2	556261.HMPREF0240_00122	1.096e-78	275.0	COG0407@1|root,COG0407@2|Bacteria,1UY51@1239|Firmicutes,24DZF@186801|Clostridia	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
TH2_k127_6370156_1	1303518.CCALI_01312	3.935e-128	420.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	iolG	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TH2_k127_6370156_0	1288963.ADIS_3921	2.137e-133	436.0	COG2133@1|root,COG2133@2|Bacteria,4NJBZ@976|Bacteroidetes,47NUG@768503|Cytophagia	976|Bacteroidetes	G	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
TH2_k127_6440422_0	1121382.JQKG01000042_gene942	2.138e-69	241.0	COG0677@1|root,COG0677@2|Bacteria,1WIW8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	UDP binding domain	-	-	1.1.1.136	ko:K02474,ko:K13015	ko00520,map00520	-	R00421,R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
TH2_k127_6440422_1	243231.GSU0689	5.09e-65	247.0	COG1033@1|root,COG1033@2|Bacteria,1QXNB@1224|Proteobacteria,43C4B@68525|delta/epsilon subdivisions,2X7ES@28221|Deltaproteobacteria,43UJS@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	MMPL family	hpnN	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
TH2_k127_6503233_15	278957.ABEA03000185_gene1566	1.286e-07	56.0	2DCDB@1|root,2ZDRD@2|Bacteria,46WHS@74201|Verrucomicrobia,3K9WV@414999|Opitutae	414999|Opitutae	S	Uncharacterized small protein (DUF2292)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2292
TH2_k127_6503233_12	1278073.MYSTI_05277	4.113e-92	318.0	COG3746@1|root,COG3746@2|Bacteria,1N2GT@1224|Proteobacteria,42W61@68525|delta/epsilon subdivisions,2WRSI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Phosphate-selective porin O and P	-	-	-	ko:K07221	-	-	-	-	ko00000,ko02000	1.B.5.1	-	-	Porin_O_P
TH2_k127_6503233_2	3988.XP_002535428.1	1.206e-149	479.0	COG1613@1|root,2RZHC@2759|Eukaryota,37VNE@33090|Viridiplantae	33090|Viridiplantae	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02048	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	SBP_bac_11
TH2_k127_6503233_13	497964.CfE428DRAFT_0281	4.626e-68	240.0	COG2866@1|root,COG2866@2|Bacteria,46SNX@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Succinylglutamate desuccinylase / Aspartoacylase family	-	-	-	-	-	-	-	-	-	-	-	-	AstE_AspA
TH2_k127_6503233_3	166318.Syn8016DRAFT_2583	7.117e-145	467.0	COG0031@1|root,COG0031@2|Bacteria,1G493@1117|Cyanobacteria,1GYXP@1129|Synechococcus	1117|Cyanobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK1	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TH2_k127_6503233_6	1236959.BAMT01000004_gene776	1.393e-122	398.0	COG0555@1|root,COG0555@2|Bacteria,1QTTU@1224|Proteobacteria,2VHKY@28216|Betaproteobacteria,2KMAW@206350|Nitrosomonadales	206350|Nitrosomonadales	O	TIGRFAM sulfate ABC transporter, inner membrane subunit CysT	-	-	-	ko:K02046	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	BPD_transp_1
TH2_k127_6503233_8	269799.Gmet_1904	4.981e-122	415.0	COG4208@1|root,COG4208@2|Bacteria,1MV8X@1224|Proteobacteria,42ND8@68525|delta/epsilon subdivisions,2WN93@28221|Deltaproteobacteria,43VJQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	cysW	-	-	ko:K02047	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	BPD_transp_1
TH2_k127_6503233_4	582744.Msip34_2160	2.546e-135	440.0	COG1118@1|root,COG1118@2|Bacteria,1QTTT@1224|Proteobacteria,2VH92@28216|Betaproteobacteria,2KKT8@206350|Nitrosomonadales	206350|Nitrosomonadales	P	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system	cysA	-	3.6.3.25	ko:K02045	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	ABC_tran,TOBE_3
TH2_k127_6503233_14	497964.CfE428DRAFT_0276	3.402e-61	217.0	COG1959@1|root,COG1959@2|Bacteria,46SPI@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
TH2_k127_6503233_7	1444711.CCJF01000005_gene340	2.594e-122	401.0	COG0715@1|root,COG0715@2|Bacteria,2JGXQ@204428|Chlamydiae	204428|Chlamydiae	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
TH2_k127_6503233_5	1403819.BATR01000053_gene1611	2.82e-128	422.0	COG1116@1|root,COG1116@2|Bacteria,46TJD@74201|Verrucomicrobia,2ITUG@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
TH2_k127_6503233_10	1336243.JAEA01000003_gene2319	4.559e-113	377.0	COG0600@1|root,COG0600@2|Bacteria,1PC26@1224|Proteobacteria,2VFP3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
TH2_k127_6503233_0	1304880.JAGB01000003_gene1323	0.0	1135.0	COG3250@1|root,COG3250@2|Bacteria,1TPDC@1239|Firmicutes,248H7@186801|Clostridia	186801|Clostridia	G	beta-galactosidase	-	-	3.2.1.23	ko:K12111	ko00052,ko00511,ko01100,map00052,map00511,map01100	-	R01678,R06114	RC00049	ko00000,ko00001,ko01000	-	-	-	Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
TH2_k127_6503233_11	497964.CfE428DRAFT_0539	1.044e-95	316.0	COG1403@1|root,COG1403@2|Bacteria,46SMP@74201|Verrucomicrobia	74201|Verrucomicrobia	L	HNH endonuclease	mcrA	-	-	-	-	-	-	-	-	-	-	-	HNH_5
TH2_k127_6503233_9	481448.Minf_1373	1.826e-121	399.0	COG0039@1|root,COG0039@2|Bacteria,46T5I@74201|Verrucomicrobia,37G8P@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.27,1.1.1.37	ko:K00016,ko:K00024	ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R00703,R01000,R03104,R07136	RC00031,RC00044	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
TH2_k127_6503233_1	1403819.BATR01000056_gene1748	2.484e-203	649.0	COG0249@1|root,COG0249@2|Bacteria,46SCK@74201|Verrucomicrobia,2ITUY@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
TH2_k127_6514272_15	762968.HMPREF9441_01837	1.315e-13	83.0	COG0627@1|root,COG0627@2|Bacteria,4NHCB@976|Bacteroidetes,2FR49@200643|Bacteroidia	976|Bacteroidetes	S	Serine hydrolase involved in the detoxification of formaldehyde	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6514272_3	28072.Nos7524_0364	4.691e-100	334.0	COG0412@1|root,COG0412@2|Bacteria,1G4HV@1117|Cyanobacteria,1HMQR@1161|Nostocales	1117|Cyanobacteria	Q	dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DLH
TH2_k127_6514272_7	247490.KSU1_D0243	1.019e-80	289.0	28HQ3@1|root,2Z7XW@2|Bacteria,2J224@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF2851)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2851
TH2_k127_6514272_5	247490.KSU1_C0526	1.06e-93	323.0	COG0265@1|root,COG0265@2|Bacteria,2IXAW@203682|Planctomycetes	203682|Planctomycetes	O	typically periplasmic contain C-terminal PDZ domain	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
TH2_k127_6514272_20	456442.Mboo_2110	5.195e-07	59.0	COG0642@1|root,arCOG02385@1|root,arCOG02385@2157|Archaea,arCOG06192@2157|Archaea	2157|Archaea	T	TIGRFAM PAS sensor protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS,Response_reg
TH2_k127_6514272_19	889378.Spiaf_1502	3.717e-07	61.0	COG1579@1|root,COG1579@2|Bacteria,2J6JN@203691|Spirochaetes	203691|Spirochaetes	S	Zn-ribbon protein, possibly nucleic acid-binding	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
TH2_k127_6514272_4	452637.Oter_0691	1.167e-96	324.0	COG0548@1|root,COG0548@2|Bacteria,46SH9@74201|Verrucomicrobia,3K7U8@414999|Opitutae	414999|Opitutae	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
TH2_k127_6514272_2	497964.CfE428DRAFT_2167	5.551e-121	400.0	COG1364@1|root,COG1364@2|Bacteria,46SEP@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
TH2_k127_6514272_6	1322246.BN4_12762	3.046e-86	297.0	COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,42MDN@68525|delta/epsilon subdivisions,2WINX@28221|Deltaproteobacteria,2M8EA@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
TH2_k127_6514272_12	289376.THEYE_A1581	1.697e-35	141.0	COG0103@1|root,COG0103@2|Bacteria,3J0N4@40117|Nitrospirae	40117|Nitrospirae	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
TH2_k127_6514272_9	349741.Amuc_1234	7.719e-51	187.0	COG0102@1|root,COG0102@2|Bacteria,46VEU@74201|Verrucomicrobia,2IUBQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
TH2_k127_6514272_0	497964.CfE428DRAFT_5188	1.862e-290	904.0	COG0443@1|root,COG0443@2|Bacteria,46SDM@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
TH2_k127_6514272_11	497964.CfE428DRAFT_5190	8.012e-38	145.0	COG0234@1|root,COG0234@2|Bacteria,46SZ8@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
TH2_k127_6514272_1	497964.CfE428DRAFT_5191	3.477e-266	828.0	COG0459@1|root,COG0459@2|Bacteria,46S9U@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
TH2_k127_6514272_16	452637.Oter_1225	4.018e-13	73.0	COG1758@1|root,COG1758@2|Bacteria,46T94@74201|Verrucomicrobia,3K9SD@414999|Opitutae	414999|Opitutae	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	-	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
TH2_k127_6514272_8	926561.KB900617_gene1766	7.856e-71	255.0	COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,3WAE6@53433|Halanaerobiales	186801|Clostridia	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
TH2_k127_6514272_10	1121289.JHVL01000015_gene2707	3.19e-40	163.0	COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,36F3D@31979|Clostridiaceae	186801|Clostridia	S	CBS domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
TH2_k127_6514272_18	163908.KB235896_gene668	3.194e-07	55.0	COG2442@1|root,COG2442@2|Bacteria,1G6VW@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
TH2_k127_6584373_1	768710.DesyoDRAFT_1775	4.576e-131	443.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K22318	-	-	-	-	ko00000	-	-	-	B12-binding,Radical_SAM
TH2_k127_6584373_2	748247.AZKH_1669	6.865e-107	352.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VJ7G@28216|Betaproteobacteria	28216|Betaproteobacteria	V	abc transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TH2_k127_6584373_0	489825.LYNGBM3L_63180	8.208e-215	685.0	COG0577@1|root,COG0577@2|Bacteria,1G0Z7@1117|Cyanobacteria,1H9BF@1150|Oscillatoriales	1117|Cyanobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TH2_k127_6606439_0	357808.RoseRS_2562	4.373e-177	569.0	COG0364@1|root,COG0364@2|Bacteria,2G5MB@200795|Chloroflexi,374UD@32061|Chloroflexia	32061|Chloroflexia	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
TH2_k127_6647539_2	1303518.CCALI_00571	3.017e-87	303.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TH2_k127_6647539_4	530564.Psta_2881	5.043e-29	136.0	COG0457@1|root,COG1729@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,2IZUV@203682|Planctomycetes	203682|Planctomycetes	H	Outer membrane lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
TH2_k127_6647539_3	1304880.JAGB01000001_gene542	1.382e-65	239.0	COG0407@1|root,COG0407@2|Bacteria,1UZD2@1239|Firmicutes,24C43@186801|Clostridia	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
TH2_k127_6647539_1	180332.JTGN01000004_gene2365	7.066e-88	305.0	28MXM@1|root,2ZB4M@2|Bacteria,1UYF1@1239|Firmicutes,24DFA@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6647539_0	278957.ABEA03000166_gene4019	4.579e-93	310.0	COG5012@1|root,COG5012@2|Bacteria,46V56@74201|Verrucomicrobia,3K7ZT@414999|Opitutae	414999|Opitutae	S	Methionine synthase B12-binding module cap domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
TH2_k127_6647539_5	264462.Bd1307	2.013e-24	111.0	2CBKC@1|root,32RTJ@2|Bacteria,1N5I0@1224|Proteobacteria,431GW@68525|delta/epsilon subdivisions,2MU7Q@213481|Bdellovibrionales,2WX2N@28221|Deltaproteobacteria	213481|Bdellovibrionales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6647539_7	386043.lwe2458	3.972e-07	54.0	COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,4HA22@91061|Bacilli,26IQY@186820|Listeriaceae	91061|Bacilli	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
TH2_k127_6647539_6	1499967.BAYZ01000050_gene2839	1.906e-08	63.0	COG0640@1|root,COG0640@2|Bacteria,2NQ13@2323|unclassified Bacteria	2|Bacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	arsR	-	3.6.4.12	ko:K03655,ko:K03892	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	HTH_20,HTH_5
TH2_k127_6730416_1	330214.NIDE2625	9.838e-19	87.0	COG0286@1|root,COG0286@2|Bacteria,3J15I@40117|Nitrospirae	40117|Nitrospirae	V	Product type e enzyme	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
TH2_k127_6730416_2	1173264.KI913949_gene4335	2.884e-08	63.0	COG4914@1|root,COG4914@2|Bacteria,1GE0D@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6730416_0	1121448.DGI_3061	1.438e-20	93.0	COG0636@1|root,COG0636@2|Bacteria,1N04D@1224|Proteobacteria,42TS9@68525|delta/epsilon subdivisions,2WQ2Y@28221|Deltaproteobacteria,2MBJE@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	ATP synthase subunit C	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
TH2_k127_6748507_2	1396141.BATP01000026_gene1004	1.762e-122	400.0	COG0147@1|root,COG0147@2|Bacteria,46S4I@74201|Verrucomicrobia,2ITH7@203494|Verrucomicrobiae	203494|Verrucomicrobiae	EH	Anthranilate synthase component I, N terminal region	-	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
TH2_k127_6748507_14	497964.CfE428DRAFT_5379	3.87e-17	84.0	COG0236@1|root,COG0236@2|Bacteria,46TAW@74201|Verrucomicrobia	74201|Verrucomicrobia	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
TH2_k127_6748507_1	1396141.BATP01000021_gene138	3.793e-124	411.0	COG0644@1|root,COG0644@2|Bacteria,46SNH@74201|Verrucomicrobia,2IVD4@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Tryptophan halogenase	-	-	-	-	-	-	-	-	-	-	-	-	Trp_halogenase
TH2_k127_6748507_15	1122226.AUHX01000001_gene880	5.58e-13	83.0	COG4258@1|root,COG4258@2|Bacteria,4PKBM@976|Bacteroidetes,1HYZW@117743|Flavobacteriia	976|Bacteroidetes	I	glycerol acyltransferase	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	Acyltransferase,MMPL,Methyltransf_25,Methyltransf_31
TH2_k127_6748507_9	497964.CfE428DRAFT_0946	9.324e-36	158.0	COG1560@1|root,COG1560@2|Bacteria,46WBV@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Bacterial lipid A biosynthesis acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Lip_A_acyltrans
TH2_k127_6748507_16	484018.BACPLE_00898	0.0002252	54.0	2A78X@1|root,30W5F@2|Bacteria,4P9HU@976|Bacteroidetes,2FV99@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	LolA
TH2_k127_6748507_11	478741.JAFS01000001_gene1831	5.366e-27	115.0	COG0764@1|root,COG0764@2|Bacteria	2|Bacteria	I	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
TH2_k127_6748507_4	478741.JAFS01000001_gene1830	7.105e-83	293.0	COG0318@1|root,COG0318@2|Bacteria,46T7I@74201|Verrucomicrobia	74201|Verrucomicrobia	IQ	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
TH2_k127_6748507_17	1163407.UU7_11502	0.0007086	50.0	COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,1RQWA@1236|Gammaproteobacteria,1X5DD@135614|Xanthomonadales	135614|Xanthomonadales	D	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	cpoB	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TolA_bind_tri
TH2_k127_6748507_3	926550.CLDAP_32200	3.208e-95	327.0	COG0246@1|root,COG0246@2|Bacteria	2|Bacteria	G	mannitol metabolic process	-	-	1.1.1.17	ko:K00009	ko00051,map00051	-	R02703	RC00085	ko00000,ko00001,ko01000	-	-	-	Mannitol_dh,Mannitol_dh_C
TH2_k127_6748507_12	635013.TherJR_2806	5.303e-23	103.0	COG1430@1|root,COG1430@2|Bacteria,1VF55@1239|Firmicutes,24QZ4@186801|Clostridia,2636A@186807|Peptococcaceae	186801|Clostridia	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
TH2_k127_6748507_6	383372.Rcas_1680	3.681e-57	210.0	COG2064@1|root,COG2064@2|Bacteria,2G6CF@200795|Chloroflexi,3766N@32061|Chloroflexia	32061|Chloroflexia	NU	PFAM type II secretion system protein	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
TH2_k127_6748507_7	401526.TcarDRAFT_1911	8.455e-56	207.0	COG4965@1|root,COG4965@2|Bacteria,1UZ3V@1239|Firmicutes,4H3YR@909932|Negativicutes	909932|Negativicutes	U	Type II secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
TH2_k127_6748507_0	574087.Acear_0236	1.073e-171	549.0	COG4962@1|root,COG4962@2|Bacteria,1TQ0Z@1239|Firmicutes,249VS@186801|Clostridia	186801|Clostridia	U	Type II IV secretion system protein	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
TH2_k127_6748507_5	1089553.Tph_c05490	1.032e-60	225.0	COG2197@1|root,COG4963@1|root,COG2197@2|Bacteria,COG4963@2|Bacteria,1UF2S@1239|Firmicutes,248CD@186801|Clostridia,42FVJ@68295|Thermoanaerobacterales	186801|Clostridia	D	ATPase MipZ	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,Response_reg
TH2_k127_6748507_8	1121271.AUCM01000004_gene1280	7.445e-38	161.0	COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,2TRNN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	Belongs to the GSP D family	pulD	-	-	ko:K02280	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	BON,Secretin,T2SS-T3SS_pil_N
TH2_k127_6748507_10	401526.TcarDRAFT_1908	3.436e-28	124.0	COG3745@1|root,COG3745@2|Bacteria,1V5FZ@1239|Firmicutes,4H4IR@909932|Negativicutes	909932|Negativicutes	U	Flp pilus assembly protein RcpC/CpaB	cpaB	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
TH2_k127_6748507_13	401526.TcarDRAFT_1914	2.572e-19	96.0	COG4655@1|root,COG4655@2|Bacteria,1V25X@1239|Firmicutes,4H46N@909932|Negativicutes	909932|Negativicutes	S	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
TH2_k127_6750289_5	338963.Pcar_1226	3.751e-78	278.0	COG1929@1|root,COG1929@2|Bacteria,1MVG9@1224|Proteobacteria,42MRF@68525|delta/epsilon subdivisions,2WNGJ@28221|Deltaproteobacteria,43UUK@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Belongs to the glycerate kinase type-1 family	glxK	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
TH2_k127_6750289_6	1121904.ARBP01000025_gene6089	5.363e-68	236.0	COG3822@1|root,COG3822@2|Bacteria,4NQZC@976|Bacteroidetes	976|Bacteroidetes	S	Pfam:DUF1498	-	-	-	-	-	-	-	-	-	-	-	-	Lyx_isomer
TH2_k127_6750289_2	1157490.EL26_21400	8.01e-118	394.0	COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,4H9YV@91061|Bacilli,279FH@186823|Alicyclobacillaceae	91061|Bacilli	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
TH2_k127_6750289_0	497964.CfE428DRAFT_3359	5.226e-223	705.0	COG0539@1|root,COG0539@2|Bacteria,46SFY@74201|Verrucomicrobia	74201|Verrucomicrobia	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
TH2_k127_6750289_1	1123508.JH636444_gene5492	2.245e-140	459.0	COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,2J25N@203682|Planctomycetes	203682|Planctomycetes	E	Amino acid kinase family	-	-	-	-	-	-	-	-	-	-	-	-	AA_kinase,Acetyltransf_1
TH2_k127_6750289_3	999419.HMPREF1077_00247	2.136e-106	359.0	COG2271@1|root,COG2271@2|Bacteria,4NGX4@976|Bacteroidetes,2FQTD@200643|Bacteroidia,22WAA@171551|Porphyromonadaceae	976|Bacteroidetes	G	Major Facilitator Superfamily	glpT	-	-	ko:K02445,ko:K07783	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.1.4.3,2.A.1.4.4,2.A.1.4.6	-	-	MFS_1
TH2_k127_6750289_8	518766.Rmar_2228	7.963e-48	192.0	COG2203@1|root,COG3829@1|root,COG4585@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,COG4585@2|Bacteria,4PI8P@976|Bacteroidetes,1FIMB@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_3,PAS
TH2_k127_6750289_9	240016.ABIZ01000001_gene4602	2.417e-33	135.0	COG0742@1|root,COG0742@2|Bacteria,46T62@74201|Verrucomicrobia,2IUEM@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Conserved hypothetical protein 95	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth95
TH2_k127_6750289_12	497964.CfE428DRAFT_1555	2.729e-13	74.0	2EMGZ@1|root,33F5K@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6750289_7	742766.HMPREF9455_02399	1.225e-60	231.0	COG0627@1|root,COG0627@2|Bacteria,4NHCB@976|Bacteroidetes,2FR49@200643|Bacteroidia	976|Bacteroidetes	S	Serine hydrolase involved in the detoxification of formaldehyde	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6750289_13	443143.GM18_2364	3.4e-08	65.0	COG3322@1|root,COG3322@2|Bacteria,1REX0@1224|Proteobacteria	1224|Proteobacteria	T	CHASE4 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6750289_10	237368.SCABRO_03100	3.616e-18	97.0	28MFE@1|root,2ZASW@2|Bacteria,2J1ME@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PRiA4_ORF3
TH2_k127_6750289_11	4929.XP_001482178.1	6.187e-16	89.0	29UUC@1|root,2RXJG@2759|Eukaryota,39R72@33154|Opisthokonta,3NWCP@4751|Fungi,3QPNY@4890|Ascomycota,3RX9S@4891|Saccharomycetes,47A4K@766764|Debaryomycetaceae	4751|Fungi	E	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
TH2_k127_6750289_4	518766.Rmar_2596	1.635e-87	293.0	COG0309@1|root,COG0309@2|Bacteria,4NG57@976|Bacteroidetes	976|Bacteroidetes	O	TIGRFAM hydrogenase expression formation protein HypE	-	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
TH2_k127_6751006_0	583355.Caka_2747	1.81e-118	389.0	COG0803@1|root,COG0803@2|Bacteria,46ZE6@74201|Verrucomicrobia,3K9N3@414999|Opitutae	414999|Opitutae	P	Belongs to the bacterial solute-binding protein 9 family	-	-	-	ko:K11604,ko:K11707	ko02010,map02010	M00317,M00319	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.7,3.A.1.15.9	-	-	ZnuA
TH2_k127_6751006_1	583355.Caka_0239	3.712e-28	117.0	COG1321@1|root,COG1321@2|Bacteria,46T7C@74201|Verrucomicrobia,3K8J0@414999|Opitutae	414999|Opitutae	K	iron dependent repressor	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
TH2_k127_6760880_2	1123008.KB905706_gene882	6.465e-30	127.0	COG3408@1|root,COG3408@2|Bacteria,4PE41@976|Bacteroidetes,2FW65@200643|Bacteroidia	976|Bacteroidetes	G	Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H
TH2_k127_6760880_1	1296416.JACB01000103_gene4027	2.142e-57	213.0	COG1226@1|root,2Z7ZD@2|Bacteria,4NYV9@976|Bacteroidetes,1IBMD@117743|Flavobacteriia,2YKFR@290174|Aquimarina	976|Bacteroidetes	P	Polycystin cation channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans
TH2_k127_6760880_0	1123368.AUIS01000023_gene925	1.635e-128	421.0	COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	antiporter	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
TH2_k127_6769554_1	583355.Caka_1765	5.74e-44	165.0	29Q4T@1|root,334S3@2|Bacteria	2|Bacteria	J	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
TH2_k127_6769554_0	595460.RRSWK_04808	1.477e-122	426.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,2IX0T@203682|Planctomycetes	203682|Planctomycetes	GT	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PEP-utilizers,PPDK_N
TH2_k127_6769554_2	118173.KB235914_gene4272	2.079e-42	177.0	COG1524@1|root,COG2931@1|root,COG1524@2|Bacteria,COG2931@2|Bacteria,1G6I0@1117|Cyanobacteria,1HB7N@1150|Oscillatoriales	1117|Cyanobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
TH2_k127_6776628_1	945713.IALB_1500	3.057e-94	328.0	COG4232@1|root,COG4232@2|Bacteria	2|Bacteria	CO	protein-disulfide reductase activity	dsbD	-	1.8.1.8	ko:K04084,ko:K06196	-	-	-	-	ko00000,ko01000,ko02000,ko03110	5.A.1.1,5.A.1.2	-	-	DsbC,DsbD,Thioredoxin,Thioredoxin_2,Thioredoxin_7
TH2_k127_6776628_6	1267533.KB906733_gene3028	6.796e-14	80.0	COG0526@1|root,COG0526@2|Bacteria,3Y4K8@57723|Acidobacteria,2JJAP@204432|Acidobacteriia	204432|Acidobacteriia	CO	Glutathione peroxidase	-	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA
TH2_k127_6776628_2	1536769.P40081_04180	2.633e-54	200.0	COG5113@1|root,COG3236@2|Bacteria,1V7IA@1239|Firmicutes,4HK8U@91061|Bacilli	91061|Bacilli	O	Domain of unknown function (DUF1768)	ybiA	-	-	ko:K09935	-	-	-	-	ko00000	-	-	-	DUF1768
TH2_k127_6776628_9	1217715.F994_02043	1.525e-05	53.0	2EJR3@1|root,33DFX@2|Bacteria,1NJB1@1224|Proteobacteria	1224|Proteobacteria	S	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6776628_5	278957.ABEA03000006_gene4219	1.248e-41	160.0	COG1595@1|root,COG1595@2|Bacteria,46WAA@74201|Verrucomicrobia,3K8C3@414999|Opitutae	414999|Opitutae	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TH2_k127_6776628_3	479434.Sthe_2092	1.762e-50	207.0	COG1074@1|root,COG1074@2|Bacteria	2|Bacteria	L	ATP-dependent DNA helicase activity	-	-	3.1.11.5,3.1.12.1,3.6.4.12	ko:K01144,ko:K07464,ko:K16898	-	-	-	-	ko00000,ko01000,ko02048,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
TH2_k127_6776628_8	290397.Adeh_3877	4.446e-09	70.0	COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1QYGN@1224|Proteobacteria,43CCX@68525|delta/epsilon subdivisions,2WXED@28221|Deltaproteobacteria,2YZUY@29|Myxococcales	28221|Deltaproteobacteria	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1
TH2_k127_6776628_4	1232410.KI421414_gene2863	4.088e-47	177.0	COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,42SCB@68525|delta/epsilon subdivisions,2WPEA@28221|Deltaproteobacteria,43UQ7@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	TIGRFAM D,D-heptose 1,7-bisphosphate phosphatase	gmhB	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_like
TH2_k127_6776628_0	497964.CfE428DRAFT_2396	6.816e-311	961.0	COG0441@1|root,COG0441@2|Bacteria,46S5A@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
TH2_k127_6777976_1	1227352.C173_25841	1.431e-29	119.0	COG0665@1|root,COG0665@2|Bacteria,1VRH3@1239|Firmicutes,4ISQR@91061|Bacilli,26SF8@186822|Paenibacillaceae	91061|Bacilli	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
TH2_k127_6777976_2	335543.Sfum_0584	2.23e-14	83.0	COG0457@1|root,COG0457@2|Bacteria,1NNP4@1224|Proteobacteria,42VPE@68525|delta/epsilon subdivisions,2WRZ3@28221|Deltaproteobacteria,2MRV3@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TAtT
TH2_k127_6777976_3	1094980.Mpsy_0240	0.0002645	52.0	COG3221@1|root,arCOG01805@2157|Archaea	2157|Archaea	P	ABC-type phosphate phosphonate transport system, periplasmic component	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
TH2_k127_6777976_0	234267.Acid_1266	6.918e-77	268.0	COG1562@1|root,COG1562@2|Bacteria,3Y3YX@57723|Acidobacteria	57723|Acidobacteria	I	PFAM Squalene phytoene synthase	-	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
TH2_k127_679081_4	234267.Acid_0296	3.929e-08	59.0	COG1194@1|root,COG1194@2|Bacteria,3Y50Y@57723|Acidobacteria	57723|Acidobacteria	L	FES	-	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,NUDIX_4
TH2_k127_679081_2	1191523.MROS_0856	1.338e-36	145.0	COG2606@1|root,COG2606@2|Bacteria	2|Bacteria	S	Cys-tRNA(Pro) hydrolase activity	-	-	-	ko:K03976,ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
TH2_k127_679081_0	159087.Daro_4030	9.465e-50	201.0	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,2VH64@28216|Betaproteobacteria,2KVFE@206389|Rhodocyclales	206389|Rhodocyclales	H	COG4206 Outer membrane cobalamin receptor protein	-	-	-	ko:K02014,ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.3	-	-	Plug,TonB_dep_Rec
TH2_k127_679081_1	575540.Isop_2406	6.162e-40	159.0	2CBKC@1|root,32RTJ@2|Bacteria,2IZRC@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_679081_3	497964.CfE428DRAFT_0194	3.569e-13	68.0	COG4284@1|root,COG4284@2|Bacteria,46SCH@74201|Verrucomicrobia	74201|Verrucomicrobia	H	UTP--glucose-1-phosphate uridylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	UDPGP
TH2_k127_6793705_1	1403819.BATR01000178_gene5964	4.531e-111	372.0	COG1520@1|root,COG1520@2|Bacteria,46TV4@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
TH2_k127_6793705_3	1321773.HMPREF9069_00899	1.951e-24	116.0	COG0673@1|root,COG0673@2|Bacteria,2GK0F@201174|Actinobacteria,4CYFV@84998|Coriobacteriia	84998|Coriobacteriia	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TH2_k127_6793705_4	338969.Rfer_2723	2.445e-20	95.0	COG1950@1|root,COG1950@2|Bacteria,1N1DF@1224|Proteobacteria,2VUY1@28216|Betaproteobacteria,4AEG0@80864|Comamonadaceae	28216|Betaproteobacteria	S	Mycobacterial 4 TMS phage holin, superfamily IV	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
TH2_k127_6793705_2	717231.Flexsi_0321	1.431e-48	179.0	COG2905@1|root,COG2905@2|Bacteria,2GGGX@200930|Deferribacteres	200930|Deferribacteres	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TH2_k127_6793705_5	497964.CfE428DRAFT_2504	2.654e-18	89.0	COG1534@1|root,COG1534@2|Bacteria,46T8G@74201|Verrucomicrobia	74201|Verrucomicrobia	J	CRS1_YhbY	-	-	-	-	-	-	-	-	-	-	-	-	CRS1_YhbY
TH2_k127_6793705_0	1444711.CCJF01000005_gene576	1.948e-141	461.0	COG1055@1|root,COG1055@2|Bacteria,2JFJT@204428|Chlamydiae	204428|Chlamydiae	P	Arsenical pump membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
TH2_k127_6875642_4	1123400.KB904746_gene1313	3.515e-28	115.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,45ZPH@72273|Thiotrichales	72273|Thiotrichales	H	PFAM aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TH2_k127_6875642_5	195250.CM001776_gene1729	9.62e-18	90.0	2DUA0@1|root,33PJB@2|Bacteria,1GD0Q@1117|Cyanobacteria,1H0Y9@1129|Synechococcus	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6875642_0	502025.Hoch_5119	2.31e-291	914.0	COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,42Q77@68525|delta/epsilon subdivisions,2WK3N@28221|Deltaproteobacteria,2YU8G@29|Myxococcales	28221|Deltaproteobacteria	C	Sulfite reductase	-	-	1.7.7.1,1.8.1.2,1.8.7.1	ko:K00366,ko:K00381,ko:K00392	ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120	M00176,M00531	R00790,R00858,R00859,R03600	RC00065,RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
TH2_k127_6875642_1	886293.Sinac_1412	3.938e-77	274.0	COG1355@1|root,COG1355@2|Bacteria,2IZEZ@203682|Planctomycetes	203682|Planctomycetes	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
TH2_k127_6875642_2	1234364.AMSF01000016_gene1600	1.79e-52	203.0	COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,1RN3A@1236|Gammaproteobacteria,1X34P@135614|Xanthomonadales	135614|Xanthomonadales	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
TH2_k127_6875642_3	1142394.PSMK_27020	6.45e-41	162.0	COG1363@1|root,COG1363@2|Bacteria	2|Bacteria	G	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28,Peptidase_M42
TH2_k127_6882835_13	344747.PM8797T_30681	3.905e-20	95.0	COG1807@1|root,COG1807@2|Bacteria,2J242@203682|Planctomycetes	203682|Planctomycetes	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TH2_k127_6882835_0	926550.CLDAP_22400	5.035e-311	964.0	COG2407@1|root,COG2407@2|Bacteria	2|Bacteria	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	fucI	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0006004,GO:0008150,GO:0008152,GO:0008736,GO:0008790,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019317,GO:0019318,GO:0019320,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0019571,GO:0042354,GO:0042355,GO:0042802,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0046372,GO:0071704,GO:1901575	5.3.1.25,5.3.1.3	ko:K01818	ko00051,ko01120,map00051,map01120	-	R03163	RC00434	ko00000,ko00001,ko01000	-	-	iECABU_c1320.ECABU_c30720,ic_1306.c3371	Fucose_iso_C,Fucose_iso_N1,Fucose_iso_N2
TH2_k127_6882835_11	404589.Anae109_3641	8.19e-37	161.0	2E3NC@1|root,32YKG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6882835_12	1449346.JQMO01000002_gene921	1.513e-23	118.0	COG1520@1|root,COG1520@2|Bacteria,2I9FJ@201174|Actinobacteria	201174|Actinobacteria	M	Beta-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	ASH,LGFP,PQQ_2,PQQ_3
TH2_k127_6882835_14	1232410.KI421415_gene3057	4.659e-20	98.0	2FE5M@1|root,3465I@2|Bacteria	2|Bacteria	S	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
TH2_k127_6882835_5	1121378.KB899700_gene1943	1.24e-105	355.0	COG3424@1|root,COG3424@2|Bacteria,1WM12@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	Q	Chalcone and stilbene synthases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Chal_sti_synt_C,Chal_sti_synt_N
TH2_k127_6882835_2	1403819.BATR01000040_gene1207	1.26e-159	526.0	COG0654@1|root,COG2020@1|root,COG0654@2|Bacteria,COG2020@2|Bacteria,46VIV@74201|Verrucomicrobia,2IWBP@203494|Verrucomicrobiae	203494|Verrucomicrobiae	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
TH2_k127_6882835_10	1313304.CALK_0692	4.464e-38	153.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
TH2_k127_6882835_7	56780.SYN_02389	2.085e-73	268.0	COG1807@1|root,COG1807@2|Bacteria,1P6JE@1224|Proteobacteria,42QEZ@68525|delta/epsilon subdivisions,2WKYB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TH2_k127_6882835_4	497964.CfE428DRAFT_1056	2.748e-132	434.0	COG3119@1|root,COG3119@2|Bacteria,46VGR@74201|Verrucomicrobia	74201|Verrucomicrobia	NP	Ig domain protein group 2 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Sulfatase
TH2_k127_6882835_8	1121439.dsat_0535	1.567e-60	216.0	COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,42N90@68525|delta/epsilon subdivisions,2WJUU@28221|Deltaproteobacteria,2M9HT@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	response regulator, receiver	-	-	-	ko:K02483,ko:K07665	ko02020,map02020	M00452,M00745	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
TH2_k127_6882835_9	596154.Alide2_1770	2.14e-43	173.0	COG3850@1|root,COG5002@1|root,COG3850@2|Bacteria,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	arlS_1	-	2.7.13.3	ko:K02484,ko:K07673	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
TH2_k127_6882835_1	240016.ABIZ01000001_gene1248	1.036e-213	687.0	COG4206@1|root,COG4206@2|Bacteria,46Z2R@74201|Verrucomicrobia,2IU2X@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
TH2_k127_6882835_6	497964.CfE428DRAFT_2309	1.446e-86	301.0	COG4191@1|root,COG4191@2|Bacteria,46U8F@74201|Verrucomicrobia	74201|Verrucomicrobia	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TH2_k127_6882835_3	497964.CfE428DRAFT_2310	1.088e-157	511.0	COG2204@1|root,COG2204@2|Bacteria,46U7R@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Sigma54_activat
TH2_k127_6893494_27	794903.OPIT5_08125	2.154e-17	92.0	COG2165@1|root,COG2165@2|Bacteria,46XZ6@74201|Verrucomicrobia,3K8NP@414999|Opitutae	414999|Opitutae	NU	general secretion pathway protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6893494_34	395961.Cyan7425_0656	1.864e-05	51.0	2EC3F@1|root,3362B@2|Bacteria,1GA28@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6893494_23	1395587.P364_0127270	3.518e-19	97.0	COG2207@1|root,COG2207@2|Bacteria,1TS5C@1239|Firmicutes,4HF34@91061|Bacilli,26T8N@186822|Paenibacillaceae	91061|Bacilli	K	AraC family transcriptional regulator	rhaS1	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18,HTH_AraC
TH2_k127_6893494_6	398580.Dshi_3014	1.707e-86	293.0	COG5285@1|root,COG5285@2|Bacteria,1R7DG@1224|Proteobacteria,2TTB2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
TH2_k127_6893494_24	880073.Calab_2491	5.73e-19	99.0	COG0407@1|root,COG0407@2|Bacteria,2NRD5@2323|unclassified Bacteria	2|Bacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
TH2_k127_6893494_11	658086.HMPREF0994_03525	2.747e-66	239.0	COG0407@1|root,COG0407@2|Bacteria,1TW8J@1239|Firmicutes,24BSH@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
TH2_k127_6893494_5	756067.MicvaDRAFT_3584	1.471e-93	316.0	COG5285@1|root,COG5285@2|Bacteria,1GGV9@1117|Cyanobacteria	1117|Cyanobacteria	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
TH2_k127_6893494_9	1120950.KB892833_gene4024	5.866e-80	276.0	COG2207@1|root,COG2207@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18,HTH_AraC
TH2_k127_6893494_8	477974.Daud_0873	2.144e-81	295.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,260DA@186807|Peptococcaceae	186801|Clostridia	C	PFAM 2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
TH2_k127_6893494_16	497964.CfE428DRAFT_3172	1.098e-33	136.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	yitI	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
TH2_k127_6893494_1	584708.Apau_2422	9.85e-222	703.0	COG0369@1|root,COG1151@2|Bacteria,3TA79@508458|Synergistetes	508458|Synergistetes	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	-	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	-	Prismane
TH2_k127_6893494_2	357808.RoseRS_1917	1.775e-157	505.0	COG0798@1|root,COG0798@2|Bacteria,2G5ZH@200795|Chloroflexi,37708@32061|Chloroflexia	32061|Chloroflexia	P	Sodium Bile acid symporter family	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
TH2_k127_6893494_18	1379270.AUXF01000001_gene2712	2.24e-25	110.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	arsR	GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0046685,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
TH2_k127_6893494_3	1121445.ATUZ01000011_gene559	5.433e-105	348.0	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,42PQM@68525|delta/epsilon subdivisions,2WJIF@28221|Deltaproteobacteria,2MGE4@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
TH2_k127_6893494_12	330214.NIDE3707	6.952e-42	158.0	COG0394@1|root,COG0394@2|Bacteria,3J1AU@40117|Nitrospirae	40117|Nitrospirae	T	Low molecular weight phosphatase family	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
TH2_k127_6893494_26	1407650.BAUB01000005_gene1267	1.009e-17	89.0	2A0JQ@1|root,2ZFXM@2|Bacteria,1GPCN@1117|Cyanobacteria,1H2WU@1129|Synechococcus	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6893494_19	1123257.AUFV01000018_gene3677	6.604e-25	118.0	COG3391@1|root,COG3391@2|Bacteria,1P03Z@1224|Proteobacteria	1224|Proteobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6893494_10	452637.Oter_2211	2.385e-69	247.0	28XS2@1|root,2ZJNH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6893494_15	472759.Nhal_2660	2.766e-34	137.0	COG3369@1|root,COG3369@2|Bacteria,1N6QZ@1224|Proteobacteria,1SCN4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Iron-binding zinc finger CDGSH type	-	-	-	-	-	-	-	-	-	-	-	-	zf-CDGSH
TH2_k127_6893494_25	290317.Cpha266_2433	6.347e-19	99.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Trypsin,Trypsin_2
TH2_k127_6893494_30	452637.Oter_1440	1.731e-11	72.0	COG0583@1|root,COG0583@2|Bacteria,46TZU@74201|Verrucomicrobia	74201|Verrucomicrobia	K	LysR substrate binding domain	-	-	-	ko:K03717	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
TH2_k127_6893494_4	240016.ABIZ01000001_gene3005	2.7e-96	320.0	COG2738@1|root,COG2738@2|Bacteria,46TH9@74201|Verrucomicrobia,2IUJW@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K06973	-	-	-	-	ko00000	-	-	-	Zn_peptidase_2
TH2_k127_6893494_31	452637.Oter_1439	5.909e-10	65.0	COG1544@1|root,COG1544@2|Bacteria,46WN8@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Sigma 54 modulation protein / S30EA ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	Ribosomal_S30AE
TH2_k127_6893494_28	1121920.AUAU01000004_gene850	7.162e-15	78.0	COG3809@1|root,COG3809@2|Bacteria	2|Bacteria	S	Transcription factor zinc-finger	-	-	-	ko:K09981	-	-	-	-	ko00000	-	-	-	zf-TFIIB
TH2_k127_6893494_7	497964.CfE428DRAFT_5497	1.125e-85	292.0	COG1192@1|root,COG1192@2|Bacteria,46SKQ@74201|Verrucomicrobia	74201|Verrucomicrobia	D	PFAM Cobyrinic acid ac-diamide synthase	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
TH2_k127_6893494_22	279808.SH1367	3.277e-19	102.0	COG0457@1|root,COG0705@1|root,COG0457@2|Bacteria,COG0705@2|Bacteria,1TQXT@1239|Firmicutes,4HCDF@91061|Bacilli,4GXW8@90964|Staphylococcaceae	91061|Bacilli	S	Rhomboid family	gluP	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Rhomboid,TPR_2,TPR_8
TH2_k127_6893494_17	332101.JIBU02000001_gene4418	1.844e-28	126.0	COG3034@1|root,COG3034@2|Bacteria,1VDHB@1239|Firmicutes,24DG5@186801|Clostridia,36HZJ@31979|Clostridiaceae	186801|Clostridia	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
TH2_k127_6893494_21	644966.Tmar_1440	7.121e-22	98.0	COG2154@1|root,COG2154@2|Bacteria,1VERE@1239|Firmicutes,24NE1@186801|Clostridia	186801|Clostridia	H	Pterin 4 alpha carbinolamine dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
TH2_k127_6893494_32	1303518.CCALI_02394	5.898e-09	69.0	COG4537@1|root,COG4537@2|Bacteria	2|Bacteria	U	Required for transformation and DNA binding	comGC	GO:0005575,GO:0005623,GO:0005886,GO:0009986,GO:0016020,GO:0044464,GO:0071944	-	ko:K02245,ko:K02456	ko03070,ko05111,map03070,map05111	M00331,M00429	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
TH2_k127_6893494_13	1121920.AUAU01000009_gene1881	2.666e-37	160.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,I-set,Ig_3,PKD,Peptidase_S8
TH2_k127_6893494_0	264732.Moth_0255	0.0	1171.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,42EYE@68295|Thermoanaerobacterales	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
TH2_k127_6893494_20	62928.azo3655	1.595e-22	113.0	2E149@1|root,32WJH@2|Bacteria,1N3U0@1224|Proteobacteria,2VUNC@28216|Betaproteobacteria,2KZ3F@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6904672_3	604331.AUHY01000025_gene1678	6.268e-27	124.0	COG0204@1|root,COG0204@2|Bacteria,1WJXG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	PFAM Phospholipid glycerol acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TH2_k127_6904672_4	1156937.MFUM_200030	2.529e-13	74.0	2DFNJ@1|root,2ZSFW@2|Bacteria,46WS2@74201|Verrucomicrobia,37HAT@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	PurA ssDNA and RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	PurA
TH2_k127_6904672_5	864051.BurJ1DRAFT_0884	1.142e-07	63.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VKD8@28216|Betaproteobacteria,1KJ37@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	response regulator	ntrX	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activ_2
TH2_k127_6904672_2	1121396.KB892900_gene2136	7.961e-89	308.0	COG1657@1|root,COG1657@2|Bacteria,1RDNW@1224|Proteobacteria,42S7H@68525|delta/epsilon subdivisions,2WNQX@28221|Deltaproteobacteria,2MMUB@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM Prenyltransferase squalene oxidase	-	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	Prenyltrans
TH2_k127_6904672_0	344747.PM8797T_07799	7.285e-120	394.0	COG0714@1|root,COG0714@2|Bacteria,2IWZM@203682|Planctomycetes	203682|Planctomycetes	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TH2_k127_6904672_1	497964.CfE428DRAFT_5662	4.51e-92	310.0	COG0249@1|root,COG0249@2|Bacteria,46SCK@74201|Verrucomicrobia	74201|Verrucomicrobia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
TH2_k127_6914810_14	5297.GMQ_22142T0	5.265e-16	95.0	COG2025@1|root,KOG3954@2759|Eukaryota,38C7G@33154|Opisthokonta,3NVHF@4751|Fungi,3UZ9F@5204|Basidiomycota,2YCAE@29000|Pucciniomycotina	4751|Fungi	C	Electron transfer flavoprotein FAD-binding domain	ETF1	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0015980,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0022904,GO:0030258,GO:0031974,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045333,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0070013,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
TH2_k127_6914810_10	945713.IALB_0028	1.868e-37	166.0	COG1960@1|root,COG1960@2|Bacteria	2|Bacteria	I	acyl-CoA dehydrogenase activity	-	-	-	ko:K06446	ko00930,ko01100,ko01120,map00930,map01100,map01120	-	R06943	RC00052	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TH2_k127_6914810_8	644966.Tmar_1118	1.703e-49	206.0	COG0644@1|root,COG0644@2|Bacteria,1TRRU@1239|Firmicutes,2481K@186801|Clostridia	186801|Clostridia	C	FAD dependent oxidoreductase	fixC	-	-	ko:K00313	-	-	-	-	ko00000,ko01000	-	-	-	DAO,FAD_binding_2,FAD_oxidored,Pyr_redox_2,Thi4
TH2_k127_6914810_7	665571.STHERM_c21260	3.35e-52	194.0	COG3880@1|root,COG3880@2|Bacteria	2|Bacteria	E	PFAM UvrB UvrC protein	omcN	-	-	ko:K08999,ko:K19411	-	-	-	-	ko00000	-	-	-	DNase-RNase,GSu_C4xC__C2xCH,Paired_CXXCH_1,UVR
TH2_k127_6914810_11	247490.KSU1_D0755	1.133e-32	138.0	COG0546@1|root,COG0546@2|Bacteria,2J0RU@203682|Planctomycetes	203682|Planctomycetes	S	HAD-hyrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
TH2_k127_6914810_13	633148.Tagg_1063	8.184e-21	108.0	COG1324@1|root,arCOG04231@2157|Archaea,2XQQS@28889|Crenarchaeota	28889|Crenarchaeota	P	PFAM CutA1 divalent ion tolerance protein	-	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
TH2_k127_6914810_12	118173.KB235914_gene1590	1.071e-25	119.0	COG0457@1|root,COG0457@2|Bacteria,1G36K@1117|Cyanobacteria,1H9PH@1150|Oscillatoriales	1117|Cyanobacteria	O	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,TIR_2,TPR_1,TPR_11,TPR_2,TPR_4,TPR_8,Trypsin_2
TH2_k127_6914810_15	382464.ABSI01000005_gene1327	4.797e-09	58.0	2DSQH@1|root,33H1Z@2|Bacteria,46TBQ@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6914810_6	1210884.HG799477_gene15426	2.799e-60	216.0	COG1187@1|root,COG1187@2|Bacteria,2IYUS@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the pseudouridine synthase RsuA family	-	-	5.4.99.20,5.4.99.22	ko:K06178,ko:K06181	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TH2_k127_6914810_16	698769.JFBD01000007_gene2615	7.023e-07	60.0	COG0860@1|root,COG3103@1|root,COG0860@2|Bacteria,COG3103@2|Bacteria,1UYPW@1239|Firmicutes,4HBVT@91061|Bacilli,4C5FP@84406|Virgibacillus	91061|Bacilli	M	Ami_3	lytC_3	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,SH3_3
TH2_k127_6914810_2	1499967.BAYZ01000171_gene5559	8.241e-107	353.0	COG0190@1|root,COG0190@2|Bacteria,2NNY1@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
TH2_k127_6914810_5	497964.CfE428DRAFT_2209	1.153e-65	235.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	pssI	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_transf_4,Glycos_transf_1,Glycos_transf_2,Sulfatase
TH2_k127_6914810_9	667014.Thein_1752	1.301e-41	166.0	COG0726@1|root,COG0726@2|Bacteria	2|Bacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1,Sulfotransfer_3
TH2_k127_6914810_3	478741.JAFS01000002_gene501	1.056e-68	251.0	COG2270@1|root,COG2270@2|Bacteria	2|Bacteria	G	Major facilitator Superfamily	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	MFS_1
TH2_k127_6914810_1	1303518.CCALI_02577	2.134e-174	556.0	COG1453@1|root,COG1453@2|Bacteria	2|Bacteria	S	Aldo/keto reductase family	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
TH2_k127_6914810_4	313628.LNTAR_19592	2.238e-66	233.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
TH2_k127_6914810_0	1122919.KB905607_gene4631	8.946e-179	571.0	COG3669@1|root,COG3669@2|Bacteria,1TQH2@1239|Firmicutes,4HDR0@91061|Bacilli,26V9U@186822|Paenibacillaceae	91061|Bacilli	G	Alpha-L-fucosidase	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
TH2_k127_6916214_2	1123073.KB899241_gene2971	2.997e-122	393.0	COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,1RRVF@1236|Gammaproteobacteria,1X5F1@135614|Xanthomonadales	135614|Xanthomonadales	V	COG0286 Type I restriction-modification system methyltransferase subunit	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
TH2_k127_6916214_3	485913.Krac_9340	5.723e-99	330.0	COG3828@1|root,COG3828@2|Bacteria,2G61G@200795|Chloroflexi	200795|Chloroflexi	S	Trehalose utilisation	-	-	-	ko:K09992	-	-	-	-	ko00000	-	-	-	ThuA
TH2_k127_6916214_1	1449063.JMLS01000005_gene3082	2.348e-140	466.0	COG0673@1|root,COG0673@2|Bacteria,1U4A4@1239|Firmicutes,4HBTG@91061|Bacilli,26QSD@186822|Paenibacillaceae	91061|Bacilli	S	Oxidoreductase	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA
TH2_k127_6916214_0	1304880.JAGB01000002_gene2262	5.773e-142	472.0	COG0673@1|root,COG0673@2|Bacteria,1U4A4@1239|Firmicutes,249UF@186801|Clostridia	186801|Clostridia	E	PFAM oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TH2_k127_6916214_5	1122611.KB903952_gene6005	4.936e-53	196.0	COG1082@1|root,COG1082@2|Bacteria,2IH92@201174|Actinobacteria,4EJH5@85012|Streptosporangiales	201174|Actinobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TH2_k127_6916214_6	1382356.JQMP01000001_gene969	2.693e-45	182.0	COG0451@1|root,COG0451@2|Bacteria,2G8UV@200795|Chloroflexi,27Z0H@189775|Thermomicrobia	189775|Thermomicrobia	M	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TH2_k127_6916214_4	1123325.JHUV01000012_gene1021	1.337e-81	280.0	COG0253@1|root,COG0253@2|Bacteria,2G4B5@200783|Aquificae	200783|Aquificae	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
TH2_k127_6916214_7	671143.DAMO_0994	2.889e-34	140.0	COG1247@1|root,COG1247@2|Bacteria	2|Bacteria	M	phosphinothricin N-acetyltransferase activity	MA20_16670	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TH2_k127_6916214_9	1121428.DESHY_60190___1	9.16e-17	83.0	COG0204@1|root,COG0204@2|Bacteria,1U8N2@1239|Firmicutes,25B02@186801|Clostridia,262IR@186807|Peptococcaceae	186801|Clostridia	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TH2_k127_6916214_8	903818.KI912268_gene2486	1.431e-17	93.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4,MucBP
TH2_k127_6933094_0	234267.Acid_2655	1.774e-50	188.0	COG3669@1|root,COG3669@2|Bacteria,3Y3XG@57723|Acidobacteria	57723|Acidobacteria	G	PFAM glycoside hydrolase, family 29	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
TH2_k127_6933094_2	1210884.HG799462_gene8477	1.404e-36	159.0	COG1520@1|root,COG1520@2|Bacteria,2J14H@203682|Planctomycetes	203682|Planctomycetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
TH2_k127_6933094_1	583355.Caka_1765	1.307e-45	169.0	29Q4T@1|root,334S3@2|Bacteria	2|Bacteria	J	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
TH2_k127_6935564_1	1109445.AGSX01000171_gene1068	1.348e-47	183.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,1Z00B@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	D	COG4974 Site-specific recombinase XerD	xerD	GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009314,GO:0009628,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0071139,GO:0071704,GO:0090304,GO:0140097,GO:1901360	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TH2_k127_6935564_0	43989.cce_1643	1.716e-70	249.0	COG0778@1|root,COG0778@2|Bacteria,1G42X@1117|Cyanobacteria,3KJXS@43988|Cyanothece	1117|Cyanobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TH2_k127_6935564_3	1530186.JQEY01000001_gene893	7.729e-05	48.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Resolvase	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TH2_k127_6943393_3	497964.CfE428DRAFT_0339	1.695e-159	517.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,46S9P@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Belongs to the precorrin methyltransferase family	cysG	-	2.1.1.107,4.2.1.75	ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
TH2_k127_6943393_7	497964.CfE428DRAFT_2626	2.943e-107	359.0	COG0404@1|root,COG0404@2|Bacteria,46UPA@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Glycine cleavage T-protein C-terminal barrel domain	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
TH2_k127_6943393_15	1396141.BATP01000007_gene5666	2.181e-45	167.0	COG0509@1|root,COG0509@2|Bacteria,46VKU@74201|Verrucomicrobia,2IUJ1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
TH2_k127_6943393_4	247490.KSU1_B0127	8.64e-134	440.0	COG0403@1|root,COG0403@2|Bacteria,2IXNG@203682|Planctomycetes	203682|Planctomycetes	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
TH2_k127_6943393_1	1304880.JAGB01000003_gene1295	1.368e-175	566.0	COG1003@1|root,COG1003@2|Bacteria,1TPK9@1239|Firmicutes,2480Q@186801|Clostridia	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS11880	GDC-P
TH2_k127_6943393_9	240016.ABIZ01000001_gene5181	3.753e-94	315.0	COG1131@1|root,COG1131@2|Bacteria,46UP6@74201|Verrucomicrobia,2IVD6@203494|Verrucomicrobiae	203494|Verrucomicrobiae	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TH2_k127_6943393_14	1267535.KB906767_gene4272	1.188e-57	207.0	COG0229@1|root,COG0229@2|Bacteria,3Y4XW@57723|Acidobacteria,2JMYE@204432|Acidobacteriia	204432|Acidobacteriia	C	SelR domain	-	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
TH2_k127_6943393_8	452637.Oter_3322	1.921e-101	341.0	COG1172@1|root,COG1172@2|Bacteria,46V2W@74201|Verrucomicrobia,3K95F@414999|Opitutae	414999|Opitutae	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440,ko:K17203	ko02010,map02010	M00212,M00590	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.11,3.A.1.2.13,3.A.1.2.16,3.A.1.2.19	-	-	BPD_transp_2
TH2_k127_6943393_0	1396141.BATP01000025_gene970	5.396e-180	577.0	COG1129@1|root,COG1129@2|Bacteria,46SG6@74201|Verrucomicrobia,2IV5X@203494|Verrucomicrobiae	2|Bacteria	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
TH2_k127_6943393_5	452637.Oter_3320	6.974e-122	399.0	COG1879@1|root,COG1879@2|Bacteria,46U2A@74201|Verrucomicrobia,3K9FQ@414999|Opitutae	414999|Opitutae	G	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
TH2_k127_6943393_10	204669.Acid345_3213	1.068e-88	300.0	COG0563@1|root,COG0563@2|Bacteria,3Y421@57723|Acidobacteria,2JI14@204432|Acidobacteriia	57723|Acidobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	-	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
TH2_k127_6943393_17	1191523.MROS_1682	1.159e-35	142.0	COG2731@1|root,COG2731@2|Bacteria	2|Bacteria	G	single-species biofilm formation	tabA_2	-	-	-	-	-	-	-	-	-	-	-	DUF386
TH2_k127_6943393_6	243231.GSU1767	2.416e-111	379.0	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,42MSB@68525|delta/epsilon subdivisions,2WJI6@28221|Deltaproteobacteria,43TW2@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
TH2_k127_6943393_19	671143.DAMO_1453	1.694e-08	64.0	2EJWJ@1|root,33DM8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6943393_12	671143.DAMO_0882	2.828e-67	238.0	COG1028@1|root,COG1028@2|Bacteria,2NQVU@2323|unclassified Bacteria	2|Bacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.5.1.33	ko:K03793	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
TH2_k127_6943393_11	1284352.AOIG01000016_gene4046	8.607e-87	297.0	COG0552@1|root,COG0552@2|Bacteria,1TPRI@1239|Firmicutes,4HA6A@91061|Bacilli,26S6C@186822|Paenibacillaceae	91061|Bacilli	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
TH2_k127_6943393_13	574087.Acear_1469	1.119e-59	227.0	COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,248H2@186801|Clostridia	186801|Clostridia	S	PHP domain	trpH	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
TH2_k127_6943393_16	583355.Caka_1576	1.052e-36	146.0	COG0781@1|root,COG0781@2|Bacteria,46VCF@74201|Verrucomicrobia,3K81J@414999|Opitutae	414999|Opitutae	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
TH2_k127_6943393_18	452637.Oter_1707	1.082e-31	129.0	COG0054@1|root,COG0054@2|Bacteria,46T5S@74201|Verrucomicrobia,3K88H@414999|Opitutae	414999|Opitutae	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
TH2_k127_6943393_2	497964.CfE428DRAFT_4667	7.553e-173	555.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,46S5K@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
TH2_k127_6958997_5	1121468.AUBR01000001_gene469	5.491e-60	213.0	COG0127@1|root,COG0127@2|Bacteria,1V6RN@1239|Firmicutes,249GK@186801|Clostridia,42GAD@68295|Thermoanaerobacterales	186801|Clostridia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
TH2_k127_6958997_6	926550.CLDAP_36350	3.094e-59	216.0	COG1208@1|root,COG1208@2|Bacteria,2G8JE@200795|Chloroflexi	200795|Chloroflexi	JM	Nucleotidyl transferase	-	-	2.7.7.13,5.4.2.8	ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TH2_k127_6958997_3	926550.CLDAP_36340	4.854e-109	370.0	COG2605@1|root,COG2605@2|Bacteria,2G5TF@200795|Chloroflexi	200795|Chloroflexi	S	PFAM GHMP kinase	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
TH2_k127_6958997_8	1121438.JNJA01000001_gene2112	1.554e-46	175.0	COG0279@1|root,COG2605@1|root,COG0279@2|Bacteria,COG2605@2|Bacteria,1QWU7@1224|Proteobacteria,42QI3@68525|delta/epsilon subdivisions,2X8DE@28221|Deltaproteobacteria,2MGSC@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	GHMP kinases C terminal	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N,SIS_2
TH2_k127_6958997_2	1304885.AUEY01000010_gene1685	4.466e-117	389.0	COG0451@1|root,COG0451@2|Bacteria,1MVI8@1224|Proteobacteria,42R49@68525|delta/epsilon subdivisions,2WNEZ@28221|Deltaproteobacteria,2MN63@213118|Desulfobacterales	28221|Deltaproteobacteria	M	NAD(P)H-binding	-	-	5.1.3.25	ko:K17947	ko00523,ko01130,map00523,map01130	-	R10279	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase
TH2_k127_6958997_7	439235.Dalk_1797	1.395e-51	192.0	COG1215@1|root,COG1215@2|Bacteria,1RJNP@1224|Proteobacteria,42ST7@68525|delta/epsilon subdivisions,2X7KP@28221|Deltaproteobacteria,2MPM9@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TH2_k127_6958997_12	485913.Krac_12282	3.802e-21	109.0	2CHUW@1|root,2ZECY@2|Bacteria,2G9K0@200795|Chloroflexi	200795|Chloroflexi	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TH2_k127_6958997_13	1463887.KL590109_gene7082	5.367e-06	59.0	COG5542@1|root,COG5542@2|Bacteria,2GJQF@201174|Actinobacteria	201174|Actinobacteria	NT	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TH2_k127_6958997_4	379066.GAU_1612	1.303e-91	307.0	COG0463@1|root,COG0463@2|Bacteria,1ZT31@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Glycosyltransferase like family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
TH2_k127_6958997_10	759914.BP951000_1517	2.465e-26	128.0	COG0457@1|root,COG0457@2|Bacteria	759914.BP951000_1517|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6958997_9	1123070.KB899256_gene2167	4.213e-41	158.0	COG1595@1|root,COG1595@2|Bacteria,46VX9@74201|Verrucomicrobia,2IUIG@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TH2_k127_6958997_11	309807.SRU_1452	3.224e-24	117.0	2DRV2@1|root,33D77@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_6958997_0	1125863.JAFN01000001_gene552	0.0	1112.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2WIZ2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
TH2_k127_6958997_1	247490.KSU1_D0869	1.7e-126	414.0	COG0604@1|root,COG0604@2|Bacteria,2IYQ6@203682|Planctomycetes	203682|Planctomycetes	C	PFAM Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
TH2_k127_6961214_4	986075.CathTA2_0789	7.034e-75	264.0	COG0486@1|root,COG0486@2|Bacteria,1TPJF@1239|Firmicutes,4HA06@91061|Bacilli	91061|Bacilli	S	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
TH2_k127_6961214_1	497964.CfE428DRAFT_2659	4.734e-145	475.0	COG1721@1|root,COG1721@2|Bacteria,46SN6@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
TH2_k127_6961214_2	398767.Glov_3575	3.97e-118	390.0	COG1300@1|root,COG1300@2|Bacteria,1Q1GN@1224|Proteobacteria,42UUJ@68525|delta/epsilon subdivisions,2WQQ0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Stage II sporulation protein M	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIM
TH2_k127_6961214_3	497964.CfE428DRAFT_2661	1.394e-81	280.0	COG1714@1|root,COG1714@2|Bacteria,46UT5@74201|Verrucomicrobia	74201|Verrucomicrobia	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
TH2_k127_6961214_0	497964.CfE428DRAFT_4943	4.566e-226	729.0	COG0577@1|root,COG0577@2|Bacteria,46U6N@74201|Verrucomicrobia	74201|Verrucomicrobia	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
TH2_k127_6961237_0	986075.CathTA2_0789	2.894e-77	266.0	COG0486@1|root,COG0486@2|Bacteria,1TPJF@1239|Firmicutes,4HA06@91061|Bacilli	91061|Bacilli	S	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
TH2_k127_6961237_1	497964.CfE428DRAFT_2659	1.248e-26	117.0	COG1721@1|root,COG1721@2|Bacteria,46SN6@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
TH2_k127_6987781_1	761193.Runsl_4923	8.12e-58	211.0	COG1874@1|root,COG1874@2|Bacteria,4NK6M@976|Bacteroidetes,47MV4@768503|Cytophagia	976|Bacteroidetes	G	Beta-galactosidase trimerisation domain	-	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_42,Glyco_hydro_42M
TH2_k127_6987781_3	148304.MAPG_09798T0	5.415e-32	141.0	COG0464@1|root,KOG0730@2759|Eukaryota,38HZQ@33154|Opisthokonta,3NYC7@4751|Fungi,3QMGG@4890|Ascomycota,21SGD@147550|Sordariomycetes	4751|Fungi	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
TH2_k127_6987781_2	589865.DaAHT2_1530	3.004e-40	156.0	2E7TR@1|root,3328U@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_704640_4	330214.NIDE0964	2.745e-10	73.0	COG0642@1|root,COG2205@2|Bacteria	330214.NIDE0964|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_704640_2	497964.CfE428DRAFT_5465	4.874e-22	104.0	COG2020@1|root,COG2020@2|Bacteria	2|Bacteria	O	methyltransferase activity	-	-	2.1.1.100	ko:K00587	ko00900,ko01130,map00900,map01130	-	R04496	RC00003,RC00460	ko00000,ko00001,ko01000	-	-	-	ICMT,PEMT
TH2_k127_704640_0	886293.Sinac_6089	1.261e-46	181.0	COG0451@1|root,COG0451@2|Bacteria,2IYS9@203682|Planctomycetes	203682|Planctomycetes	M	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TH2_k127_704640_3	479434.Sthe_1707	1.78e-18	90.0	COG5652@1|root,COG5652@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
TH2_k127_704640_1	269799.Gmet_2728	3.844e-41	161.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,42MC5@68525|delta/epsilon subdivisions,2WIT5@28221|Deltaproteobacteria,43TM8@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
TH2_k127_7068799_11	517722.AEUE01000008_gene38	1.04e-05	57.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,2K08H@204457|Sphingomonadales	204457|Sphingomonadales	M	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
TH2_k127_7068799_3	497964.CfE428DRAFT_2401	2.544e-100	344.0	COG0006@1|root,COG0006@2|Bacteria,46SKG@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Belongs to the peptidase M24B family	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
TH2_k127_7068799_2	497964.CfE428DRAFT_2716	5.186e-105	352.0	COG0533@1|root,COG0533@2|Bacteria,46SEH@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
TH2_k127_7068799_1	497964.CfE428DRAFT_2715	2.712e-117	391.0	COG0793@1|root,COG0793@2|Bacteria,46SM7@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
TH2_k127_7068799_5	909663.KI867150_gene2007	1.704e-83	291.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42NQP@68525|delta/epsilon subdivisions,2WIQD@28221|Deltaproteobacteria,2MR82@213462|Syntrophobacterales	28221|Deltaproteobacteria	BQ	PFAM histone deacetylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
TH2_k127_7068799_0	765952.PUV_14580	8.794e-308	954.0	COG0365@1|root,COG0365@2|Bacteria,2JFRM@204428|Chlamydiae	204428|Chlamydiae	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
TH2_k127_7068799_10	1254432.SCE1572_49335	2.591e-06	56.0	COG4096@1|root,COG4096@2|Bacteria,1QTS7@1224|Proteobacteria,42MXU@68525|delta/epsilon subdivisions,2WK28@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Type III restriction protein res subunit	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	EcoEI_R_C,HSDR_N,Helicase_C,ResIII
TH2_k127_7068799_7	278957.ABEA03000106_gene1851	4.642e-17	87.0	COG4096@1|root,COG4096@2|Bacteria,46VP9@74201|Verrucomicrobia,3K9SC@414999|Opitutae	414999|Opitutae	L	EcoEI R protein C-terminal	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	EcoEI_R_C,Helicase_C,ResIII
TH2_k127_7068799_6	1396141.BATP01000007_gene5515	1.5e-65	231.0	2CAEK@1|root,2ZCPG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_7068799_8	1396141.BATP01000007_gene5515	2.948e-10	64.0	2CAEK@1|root,2ZCPG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_7068799_4	1033732.CAHI01000007_gene2094	9.529e-88	307.0	COG2010@1|root,COG3533@1|root,COG2010@2|Bacteria,COG3533@2|Bacteria,4NF8W@976|Bacteroidetes	976|Bacteroidetes	C	glycosyl hydrolase of	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Big_4,DUF4986,Glyco_hydro_127,Laminin_G_3
TH2_k127_7089671_4	1121004.ATVC01000013_gene2055	5.622e-08	55.0	COG0824@1|root,COG0824@2|Bacteria,1RF7Q@1224|Proteobacteria,2VR5T@28216|Betaproteobacteria,2KRGT@206351|Neisseriales	206351|Neisseriales	S	thioesterase K01075	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_2
TH2_k127_7089671_0	1379698.RBG1_1C00001G1432	2.231e-151	525.0	COG1196@1|root,COG1196@2|Bacteria,2NNYZ@2323|unclassified Bacteria	2|Bacteria	D	Required for chromosome condensation and partitioning	smc	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03529,ko:K19171	-	-	-	-	ko00000,ko02048,ko03036	-	-	-	SMC_N,SMC_hinge
TH2_k127_7089671_2	1396418.BATQ01000046_gene6154	3.074e-31	126.0	COG0023@1|root,COG0023@2|Bacteria,46VY8@74201|Verrucomicrobia,2IWER@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Translation initiation factor SUI1	-	-	-	-	-	-	-	-	-	-	-	-	SUI1
TH2_k127_7089671_1	497964.CfE428DRAFT_2140	6.763e-138	455.0	COG0265@1|root,COG0265@2|Bacteria,46SHP@74201|Verrucomicrobia	74201|Verrucomicrobia	O	PFAM peptidase S1 and S6 chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
TH2_k127_7089671_3	1160718.SU9_09754	7.554e-14	79.0	COG1503@1|root,COG1503@2|Bacteria,2I8DT@201174|Actinobacteria	201174|Actinobacteria	J	translation release factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_7152455_0	497964.CfE428DRAFT_5484	4.259e-128	419.0	COG0323@1|root,COG0323@2|Bacteria,46SG5@74201|Verrucomicrobia	74201|Verrucomicrobia	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
TH2_k127_7152455_1	377629.TERTU_3237	4.062e-58	224.0	COG3394@1|root,COG3394@2|Bacteria,1PCNH@1224|Proteobacteria,1SXSC@1236|Gammaproteobacteria,2PPWQ@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	G	YdjC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YdjC
TH2_k127_7152455_2	377629.TERTU_3233	2.466e-40	160.0	COG1215@1|root,COG1215@2|Bacteria,1PCBQ@1224|Proteobacteria,1SX97@1236|Gammaproteobacteria,2PP76@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	M	Glycosyl transferase family 21	-	-	2.4.1.80	ko:K00720	ko00600,ko01100,map00600,map01100	M00066	R01497	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000	4.D.1.4	GT21	-	Glyco_transf_21
TH2_k127_7197332_1	1121920.AUAU01000002_gene2160	1.098e-23	105.0	COG0731@1|root,COG0731@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TH2_k127_7197332_3	497964.CfE428DRAFT_6094	2.23e-06	53.0	COG0475@1|root,COG0475@2|Bacteria	2|Bacteria	P	glutathione-regulated potassium exporter activity	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
TH2_k127_7197332_0	1396418.BATQ01000136_gene3705	6.6e-114	379.0	COG1502@1|root,COG1502@2|Bacteria,46U9X@74201|Verrucomicrobia,2ITQD@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	Phospholipase D. Active site motifs.	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
TH2_k127_7197332_2	794903.OPIT5_24905	1.454e-07	55.0	COG1684@1|root,COG1684@2|Bacteria,46WEA@74201|Verrucomicrobia,3K852@414999|Opitutae	414999|Opitutae	NU	Bacterial export proteins, family 1	-	-	-	ko:K02421	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1
TH2_k127_7201959_1	316067.Geob_1014	7.333e-151	491.0	COG3005@1|root,COG3005@2|Bacteria,1R956@1224|Proteobacteria,42Q0X@68525|delta/epsilon subdivisions,2WMHI@28221|Deltaproteobacteria,43U0A@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	NapC/NirT cytochrome c family, N-terminal region	-	GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
TH2_k127_7201959_15	880073.Calab_3408	4.016e-39	153.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	Cytochrome_C554,DUF11,SLH
TH2_k127_7201959_6	1125863.JAFN01000001_gene1123	1.139e-79	278.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,42MUG@68525|delta/epsilon subdivisions,2WISB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
TH2_k127_7201959_0	1121920.AUAU01000001_gene2268	4.732e-160	526.0	COG2864@1|root,COG2864@2|Bacteria,3Y6QW@57723|Acidobacteria	57723|Acidobacteria	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Ni_hydr_CYTB
TH2_k127_7201959_18	1232410.KI421421_gene3420	5.363e-11	74.0	COG3303@1|root,COG3303@2|Bacteria,1R0AQ@1224|Proteobacteria,43CT6@68525|delta/epsilon subdivisions,2X80R@28221|Deltaproteobacteria,43VYX@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Cytochrome c3	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
TH2_k127_7201959_12	404589.Anae109_1800	4.369e-63	237.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42M97@68525|delta/epsilon subdivisions,2WJB4@28221|Deltaproteobacteria,2Z1ZF@29|Myxococcales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	hmcB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Fer4_11,Fer4_4,Fer4_7
TH2_k127_7201959_4	234267.Acid_4205	1.394e-89	316.0	COG5557@1|root,COG5557@2|Bacteria,3Y3RF@57723|Acidobacteria	57723|Acidobacteria	C	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
TH2_k127_7201959_8	269799.Gmet_0554	6.908e-77	276.0	COG4191@1|root,COG4191@2|Bacteria,1R5Q1@1224|Proteobacteria,42TFH@68525|delta/epsilon subdivisions,2WPEH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase HAMP	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TH2_k127_7201959_2	1232410.KI421428_gene1054	2.145e-147	479.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WKJX@28221|Deltaproteobacteria,43S25@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Domains REC, sigma54 interaction, HTH8	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH2_k127_7201959_7	452637.Oter_2583	1.349e-79	274.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	omcI	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
TH2_k127_7201959_9	1191523.MROS_2048	1.533e-70	267.0	COG0737@1|root,COG3303@1|root,COG0737@2|Bacteria,COG3303@2|Bacteria	2|Bacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	1.7.2.2	ko:K03385	ko00910,ko01120,ko05132,map00910,map01120,map05132	M00530	R05712	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	5_nucleotid_C,Cytochrom_C552,Cytochrome_C554,Paired_CXXCH_1,SBP_bac_8,SLH
TH2_k127_7201959_5	509635.N824_12595	1.283e-83	290.0	COG0668@1|root,COG0668@2|Bacteria,4NHU7@976|Bacteroidetes,1IV9D@117747|Sphingobacteriia	976|Bacteroidetes	M	Mechanosensitive ion channel	-	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
TH2_k127_7201959_10	278957.ABEA03000067_gene3959	7.399e-70	244.0	COG0730@1|root,COG0730@2|Bacteria,46VE4@74201|Verrucomicrobia,3K7RM@414999|Opitutae	414999|Opitutae	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TH2_k127_7201959_13	1337936.IJ00_27485	5.42e-60	215.0	COG1216@1|root,COG1216@2|Bacteria,1G0X3@1117|Cyanobacteria,1HK6N@1161|Nostocales	1117|Cyanobacteria	S	PFAM Glycosyl transferase family 2	-	-	-	ko:K09931	-	-	-	-	ko00000	-	-	-	DUF2064,Glycos_transf_2
TH2_k127_7201959_11	497964.CfE428DRAFT_3924	3.159e-63	222.0	COG0231@1|root,COG0231@2|Bacteria,46SQH@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
TH2_k127_7201959_3	1396141.BATP01000028_gene2349	4.777e-102	342.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,46S8G@74201|Verrucomicrobia,2ITHA@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	SIS domain	-	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
TH2_k127_7201959_16	1122947.FR7_1501	8.248e-28	127.0	COG1063@1|root,COG1063@2|Bacteria,1U9ZD@1239|Firmicutes,4H2SS@909932|Negativicutes	909932|Negativicutes	E	PFAM Alcohol dehydrogenase GroES domain protein, Alcohol dehydrogenase zinc-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
TH2_k127_7201959_17	478741.JAFS01000001_gene1703	8.851e-23	109.0	COG1073@1|root,COG1073@2|Bacteria,46VGX@74201|Verrucomicrobia,37GJ0@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_7201959_14	1211814.CAPG01000056_gene2763	1.409e-48	179.0	COG0691@1|root,COG0691@2|Bacteria,1V3IJ@1239|Firmicutes,4HGZX@91061|Bacilli,1ZFJ0@1386|Bacillus	91061|Bacilli	O	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070930,GO:0071704,GO:1901564	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
TH2_k127_7206811_4	1396418.BATQ01000085_gene1110	4.08e-69	245.0	COG0196@1|root,COG0196@2|Bacteria,46SZ6@74201|Verrucomicrobia,2IU48@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	Riboflavin kinase	-	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
TH2_k127_7206811_7	452637.Oter_0398	2.456e-35	144.0	COG4786@1|root,COG4786@2|Bacteria,46VRG@74201|Verrucomicrobia,3K81G@414999|Opitutae	414999|Opitutae	N	Flagellar basal body rod FlgEFG protein C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Flg_bbr_C
TH2_k127_7206811_2	555079.Toce_0388	5.737e-110	372.0	COG1641@1|root,COG1641@2|Bacteria,1TPAV@1239|Firmicutes,247ZH@186801|Clostridia,42FR9@68295|Thermoanaerobacterales	186801|Clostridia	S	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes	larC	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
TH2_k127_7206811_10	1116232.AHBF01000025_gene6925	4.048e-12	69.0	COG2835@1|root,COG2835@2|Bacteria	2|Bacteria	EG	tetraacyldisaccharide 4'-kinase activity	ycaR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.7.1.130	ko:K00912,ko:K09791	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Trm112p
TH2_k127_7206811_8	583355.Caka_2172	2.471e-35	145.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_7C,Glycos_transf_2
TH2_k127_7206811_1	661478.OP10G_4385	2.486e-213	673.0	COG1964@1|root,COG1964@2|Bacteria	2|Bacteria	Q	Radical SAM superfamily	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
TH2_k127_7206811_9	525904.Tter_1427	4.7e-16	85.0	COG1716@1|root,COG1716@2|Bacteria,2NQ4X@2323|unclassified Bacteria	2|Bacteria	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3662,FHA,Yop-YscD_cpl
TH2_k127_7206811_5	794903.OPIT5_13315	2.332e-64	248.0	COG3063@1|root,COG3063@2|Bacteria,46UEF@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	Type IV pilus biogenesis stability protein PilW	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_7206811_3	1403819.BATR01000104_gene3590	9.151e-87	305.0	COG3858@1|root,COG3858@2|Bacteria,46VGZ@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function (DUF3142)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3142
TH2_k127_7206811_6	1123508.JH636450_gene7227	2.85e-49	182.0	2DBSY@1|root,32TY1@2|Bacteria,2J0DA@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_7206811_0	1382306.JNIM01000001_gene1323	1.244e-229	739.0	COG0058@1|root,COG0058@2|Bacteria,2G5KG@200795|Chloroflexi	200795|Chloroflexi	G	PFAM glycosyl transferase, family 35	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
TH2_k127_7206934_1	160799.PBOR_28850	1.108e-81	289.0	COG3459@1|root,COG3459@2|Bacteria,1TQY8@1239|Firmicutes,4HUUV@91061|Bacilli,26VES@186822|Paenibacillaceae	91061|Bacilli	G	Glycosyltransferase family 36	-	-	2.4.1.20	ko:K00702	ko00500,ko01100,map00500,map01100	-	R00952	RC00049	ko00000,ko00001,ko01000	-	GT36	-	Glyco_hydro_36,Glyco_transf_36
TH2_k127_7206934_0	497964.CfE428DRAFT_6367	1.738e-85	290.0	COG0426@1|root,COG0426@2|Bacteria,46UCH@74201|Verrucomicrobia	74201|Verrucomicrobia	C	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_7206934_2	330214.NIDE0014	6.876e-26	108.0	COG0655@1|root,COG2146@1|root,COG0655@2|Bacteria,COG2146@2|Bacteria	2|Bacteria	P	nitrite reductase [NAD(P)H] activity	-	-	1.2.3.3,1.6.5.2,1.7.1.15	ko:K00158,ko:K00363,ko:K03809,ko:K05710	ko00130,ko00360,ko00620,ko00910,ko01100,ko01110,ko01120,ko01220,map00130,map00360,map00620,map00910,map01100,map01110,map01120,map01220	M00530,M00545	R00207,R00787,R02964,R03643,R03816,R06782,R06783	RC00098,RC00176,RC00819,RC02745	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_red,Rieske,TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TH2_k127_7292031_2	1242864.D187_004059	1.047e-20	108.0	COG2885@1|root,COG3055@1|root,COG2885@2|Bacteria,COG3055@2|Bacteria,1R4WG@1224|Proteobacteria,42TD5@68525|delta/epsilon subdivisions,2WP3U@28221|Deltaproteobacteria,2YZ06@29|Myxococcales	28221|Deltaproteobacteria	M	HYR domain	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	HYR,Kelch_4,OMP_b-brl,OmpA,TSP_3
TH2_k127_7292031_1	502025.Hoch_6795	5.266e-26	126.0	COG5184@1|root,COG5184@2|Bacteria,1P1C6@1224|Proteobacteria,4310A@68525|delta/epsilon subdivisions,2WWWF@28221|Deltaproteobacteria,2Z029@29|Myxococcales	28221|Deltaproteobacteria	DZ	Putative metal-binding motif	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE
TH2_k127_7292031_0	886293.Sinac_6818	1.087e-171	548.0	COG2304@1|root,COG2304@2|Bacteria,2IYBK@203682|Planctomycetes	203682|Planctomycetes	K	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	DUF3520,VWA,vWF_A
TH2_k127_7330081_0	1121015.N789_06360	5.117e-109	375.0	COG5267@1|root,COG5267@2|Bacteria,1MWJK@1224|Proteobacteria,1RSEC@1236|Gammaproteobacteria,1X44S@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF1800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
TH2_k127_7338466_9	1121939.L861_18590	1.288e-05	48.0	COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,1RMEQ@1236|Gammaproteobacteria,1XI08@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
TH2_k127_7338466_8	744872.Spica_0033	1.131e-11	66.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,2J68A@203691|Spirochaetes	203691|Spirochaetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
TH2_k127_7338466_5	1396418.BATQ01000079_gene803	1.143e-71	256.0	COG3335@1|root,COG3335@2|Bacteria	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_28,HTH_29,HTH_32
TH2_k127_7338466_6	1123242.JH636438_gene5714	2.204e-50	183.0	COG4276@1|root,COG4276@2|Bacteria,2J0FI@203682|Planctomycetes	203682|Planctomycetes	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
TH2_k127_7338466_7	309801.trd_A0753	3.037e-23	109.0	arCOG06227@1|root,2ZB70@2|Bacteria,2GAEH@200795|Chloroflexi,27Z5J@189775|Thermomicrobia	189775|Thermomicrobia	S	Domain of unknown function (DUF4397)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4397
TH2_k127_7338466_10	1379270.AUXF01000004_gene2950	0.0007201	53.0	29AYY@1|root,2ZXXY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_7338466_2	1123508.JH636439_gene1504	2.539e-102	360.0	COG1215@1|root,COG1215@2|Bacteria,2J02Q@203682|Planctomycetes	203682|Planctomycetes	M	glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TH2_k127_7338466_4	1210884.HG799464_gene10821	2.01e-72	256.0	COG0204@1|root,COG0204@2|Bacteria,2IZPB@203682|Planctomycetes	203682|Planctomycetes	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
TH2_k127_7338466_0	1123508.JH636439_gene1502	1.466e-230	726.0	COG1233@1|root,COG1233@2|Bacteria,2IYPF@203682|Planctomycetes	203682|Planctomycetes	Q	COG1233 Phytoene dehydrogenase and related	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
TH2_k127_7338466_3	1238182.C882_1170	5.836e-81	286.0	COG1012@1|root,COG1012@2|Bacteria,1MVGW@1224|Proteobacteria,2TR9T@28211|Alphaproteobacteria,2JVAH@204441|Rhodospirillales	204441|Rhodospirillales	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
TH2_k127_7338466_1	1210884.HG799464_gene10819	4.064e-226	711.0	COG1233@1|root,COG1233@2|Bacteria,2IYJC@203682|Planctomycetes	203682|Planctomycetes	Q	Flavin containing amine oxidoreductase	-	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
TH2_k127_734118_4	1396141.BATP01000047_gene3944	7.561e-39	146.0	COG1943@1|root,COG1943@2|Bacteria,46X0P@74201|Verrucomicrobia,2IVW1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_734118_2	1192034.CAP_1853	1.485e-119	394.0	COG0673@1|root,COG0673@2|Bacteria,1MUZI@1224|Proteobacteria	1224|Proteobacteria	S	oxidoreductase	afr	-	1.1.1.292	ko:K19181	-	-	-	-	ko00000,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TH2_k127_734118_8	452637.Oter_0054	7.958e-07	57.0	2AX8K@1|root,31P7E@2|Bacteria,46XUD@74201|Verrucomicrobia,3K874@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_734118_5	478741.JAFS01000001_gene1565	3.277e-31	128.0	COG4747@1|root,COG4747@2|Bacteria,46SXP@74201|Verrucomicrobia,37GPF@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_734118_0	1161401.ASJA01000017_gene1283	5.172e-242	762.0	COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,2TQNJ@28211|Alphaproteobacteria,43WEP@69657|Hyphomonadaceae	28211|Alphaproteobacteria	P	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	cysC	-	2.7.1.25,2.7.7.4	ko:K00955	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU
TH2_k127_734118_6	459349.CLOAM0723	2.687e-28	129.0	COG0614@1|root,COG0614@2|Bacteria	2|Bacteria	P	abc-type fe3 -hydroxamate transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
TH2_k127_734118_3	1430440.MGMSRv2_0470	3.341e-100	359.0	COG0175@1|root,COG0175@2|Bacteria,1MUCZ@1224|Proteobacteria,2TT2D@28211|Alphaproteobacteria,2JQKR@204441|Rhodospirillales	204441|Rhodospirillales	EH	COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase) FAD synthetase and related enzymes	cysD	-	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
TH2_k127_734118_1	1403819.BATR01000002_gene16	2.331e-178	577.0	COG1132@1|root,COG1132@2|Bacteria,46TV7@74201|Verrucomicrobia,2ITQH@203494|Verrucomicrobiae	203494|Verrucomicrobiae	V	ABC transporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
TH2_k127_734118_7	243090.RB2051	1.543e-13	80.0	COG3137@1|root,COG3137@2|Bacteria,2J024@203682|Planctomycetes	203682|Planctomycetes	M	Protein of unknown function, DUF481	-	-	-	-	-	-	-	-	-	-	-	-	DUF481
TH2_k127_7344600_17	497964.CfE428DRAFT_2209	4.233e-64	232.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	pssI	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_transf_4,Glycos_transf_1,Glycos_transf_2,Sulfatase
TH2_k127_7344600_19	452637.Oter_3874	2.759e-60	213.0	COG1259@1|root,COG1259@2|Bacteria,46SW6@74201|Verrucomicrobia,3K81A@414999|Opitutae	414999|Opitutae	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
TH2_k127_7344600_16	204669.Acid345_1944	2.479e-69	244.0	COG1945@1|root,COG1945@2|Bacteria,3Y3KR@57723|Acidobacteria,2JIBD@204432|Acidobacteriia	204432|Acidobacteriia	S	Pyruvoyl-dependent arginine decarboxylase (PvlArgDC)	-	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
TH2_k127_7344600_6	886293.Sinac_3542	6.722e-133	429.0	COG0388@1|root,COG0388@2|Bacteria,2IX91@203682|Planctomycetes	203682|Planctomycetes	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
TH2_k127_7344600_1	497964.CfE428DRAFT_2088	1.165e-206	647.0	COG0192@1|root,COG0192@2|Bacteria,46S4V@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
TH2_k127_7344600_9	497964.CfE428DRAFT_2622	5.154e-110	363.0	COG0152@1|root,COG0152@2|Bacteria,46SIP@74201|Verrucomicrobia	74201|Verrucomicrobia	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
TH2_k127_7344600_8	326427.Cagg_1016	4.782e-117	420.0	COG0260@1|root,COG0260@2|Bacteria,2G617@200795|Chloroflexi,37528@32061|Chloroflexia	32061|Chloroflexia	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
TH2_k127_7344600_12	383372.Rcas_2148	3.608e-89	321.0	COG0745@1|root,COG2203@1|root,COG2204@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,2G7Y4@200795|Chloroflexi,374VX@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase A domain protein	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA,PAS_4,Response_reg
TH2_k127_7344600_28	1403819.BATR01000104_gene3549	5.233e-21	98.0	COG3688@1|root,COG3688@2|Bacteria,46T34@74201|Verrucomicrobia,2IW9T@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	YacP-like NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN_YacP
TH2_k127_7344600_4	497964.CfE428DRAFT_1789	3.735e-144	468.0	COG0195@1|root,COG0195@2|Bacteria,46TRP@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
TH2_k127_7344600_2	1158318.ATXC01000002_gene1592	4.466e-183	601.0	COG0532@1|root,COG0532@2|Bacteria,2G3W1@200783|Aquificae	200783|Aquificae	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N
TH2_k127_7344600_30	497964.CfE428DRAFT_1791	1.139e-15	81.0	COG0858@1|root,COG0858@2|Bacteria,46TBI@74201|Verrucomicrobia	74201|Verrucomicrobia	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
TH2_k127_7344600_13	497964.CfE428DRAFT_1792	5.136e-89	304.0	COG0618@1|root,COG0618@2|Bacteria,46T03@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM phosphoesterase RecJ domain protein	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
TH2_k127_7344600_15	278957.ABEA03000104_gene314	4.34e-82	281.0	COG4279@1|root,COG4279@2|Bacteria,46V8E@74201|Verrucomicrobia	74201|Verrucomicrobia	S	SWIM zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
TH2_k127_7344600_0	391735.Veis_0811	3.012e-303	958.0	COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,2VIEC@28216|Betaproteobacteria,4ABAD@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM SNF2-related protein	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	DUF3670,Helicase_C,SNF2_N,SWIM
TH2_k127_7344600_20	292459.STH2574	7.45e-55	202.0	COG1387@1|root,COG1387@2|Bacteria,1TRKS@1239|Firmicutes,249TM@186801|Clostridia	186801|Clostridia	E	Histidinol phosphate phosphatase, HisJ family	-	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP,PHP_C
TH2_k127_7344600_14	330214.NIDE3081	2.522e-86	291.0	COG3253@1|root,COG3253@2|Bacteria	2|Bacteria	S	peroxidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
TH2_k127_7344600_29	338966.Ppro_1299	4.431e-20	94.0	COG2138@1|root,COG2138@2|Bacteria,1QXPH@1224|Proteobacteria,42XIT@68525|delta/epsilon subdivisions,2WSVI@28221|Deltaproteobacteria,43UWN@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	PFAM cobalamin (vitamin B12) biosynthesis CbiX protein	cbiX	-	4.99.1.3	ko:K03795	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05807	RC01012	ko00000,ko00001,ko01000	-	-	-	2Fe-2S_thioredx,CbiX
TH2_k127_7344600_25	935948.KE386495_gene1418	1.172e-43	171.0	COG1082@1|root,COG1082@2|Bacteria,1UYRD@1239|Firmicutes,2498N@186801|Clostridia,42FV9@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Xylose isomerase	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TH2_k127_7344600_18	247490.KSU1_B0710	1.346e-62	222.0	COG0546@1|root,COG0546@2|Bacteria,2J0GC@203682|Planctomycetes	203682|Planctomycetes	S	haloacid dehalogenase-like hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
TH2_k127_7344600_11	1156937.MFUM_230022	9.949e-90	313.0	COG1044@1|root,COG1044@2|Bacteria,46SAD@74201|Verrucomicrobia,37GE9@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,LpxD
TH2_k127_7344600_27	497964.CfE428DRAFT_4704	1.114e-21	102.0	COG2825@1|root,COG2825@2|Bacteria,46T22@74201|Verrucomicrobia	74201|Verrucomicrobia	M	PFAM outer membrane chaperone Skp (OmpH)	hlpA	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
TH2_k127_7344600_3	1156937.MFUM_230019	1.334e-182	599.0	COG4775@1|root,COG4775@2|Bacteria,46S5F@74201|Verrucomicrobia,37GCF@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	Surface antigen	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
TH2_k127_7344600_7	1131269.AQVV01000050_gene421	8.471e-124	413.0	COG0305@1|root,COG0305@2|Bacteria	2|Bacteria	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
TH2_k127_7344600_26	986075.CathTA2_2104	1.387e-28	120.0	COG0359@1|root,COG0359@2|Bacteria,1V6QG@1239|Firmicutes,4HIKJ@91061|Bacilli	91061|Bacilli	J	binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
TH2_k127_7344600_31	1125701.HMPREF1221_00385	1.741e-15	78.0	COG0238@1|root,COG0238@2|Bacteria,2J8ZY@203691|Spirochaetes	203691|Spirochaetes	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
TH2_k127_7344600_23	497964.CfE428DRAFT_1541	8.295e-45	167.0	COG0629@1|root,COG0629@2|Bacteria,46VGA@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
TH2_k127_7344600_32	497964.CfE428DRAFT_1542	1.41e-10	66.0	COG0360@1|root,COG0360@2|Bacteria	2|Bacteria	J	Binds together with S18 to 16S ribosomal RNA	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
TH2_k127_7344600_21	321332.CYB_0725	8.141e-53	193.0	COG0193@1|root,COG0193@2|Bacteria,1G0D0@1117|Cyanobacteria,1GZ78@1129|Synechococcus	1117|Cyanobacteria	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
TH2_k127_7344600_22	497964.CfE428DRAFT_1544	6.355e-51	191.0	COG1825@1|root,COG1825@2|Bacteria,46SZS@74201|Verrucomicrobia	74201|Verrucomicrobia	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
TH2_k127_7344600_5	478741.JAFS01000001_gene1562	4.062e-133	432.0	COG0462@1|root,COG0462@2|Bacteria,46SVH@74201|Verrucomicrobia,37GGN@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
TH2_k127_7344600_10	472759.Nhal_0189	2.897e-107	360.0	COG2234@1|root,COG2234@2|Bacteria,1MXZS@1224|Proteobacteria,1S0QR@1236|Gammaproteobacteria,1X00D@135613|Chromatiales	135613|Chromatiales	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
TH2_k127_7344600_24	497964.CfE428DRAFT_5152	2.072e-44	173.0	2CBS1@1|root,32RTY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_7391732_32	278957.ABEA03000166_gene4031	1.452e-32	131.0	COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,46V5M@74201|Verrucomicrobia,3K9Z9@414999|Opitutae	414999|Opitutae	K	PFAM helix-turn-helix- domain containing protein AraC type	-	-	-	ko:K02855	-	-	-	-	ko00000,ko03000	-	-	-	HTH_18
TH2_k127_7391732_20	666509.RCA23_c03800	1.101e-67	244.0	COG3239@1|root,COG3239@2|Bacteria,1R42Z@1224|Proteobacteria,2TU07@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
TH2_k127_7391732_29	497964.CfE428DRAFT_5924	1.1e-35	149.0	COG0470@1|root,COG0470@2|Bacteria,46T6T@74201|Verrucomicrobia	74201|Verrucomicrobia	L	DNA polymerase III, delta subunit	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
TH2_k127_7391732_21	497964.CfE428DRAFT_5925	1.388e-65	231.0	COG0125@1|root,COG0125@2|Bacteria,46ST1@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
TH2_k127_7391732_39	903818.KI912268_gene1360	3.897e-17	87.0	COG2984@1|root,COG4191@1|root,COG2984@2|Bacteria,COG4191@2|Bacteria,3Y2IQ@57723|Acidobacteria	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
TH2_k127_7391732_12	697281.Mahau_1635	5.887e-97	321.0	COG0047@1|root,COG0047@2|Bacteria,1TP1B@1239|Firmicutes,24A2E@186801|Clostridia,42EVD@68295|Thermoanaerobacterales	186801|Clostridia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
TH2_k127_7391732_37	218284.CCDN010000002_gene1986	4.216e-18	87.0	COG1828@1|root,COG1828@2|Bacteria,1VEH1@1239|Firmicutes,4HP0E@91061|Bacilli,1ZHUG@1386|Bacillus	91061|Bacilli	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU06460	PurS
TH2_k127_7391732_31	1168034.FH5T_09660	1.447e-32	134.0	COG1556@1|root,COG1556@2|Bacteria,4NIGX@976|Bacteroidetes	976|Bacteroidetes	S	Lactate utilization protein B C	-	-	-	ko:K00782	-	-	-	-	ko00000	-	-	-	LUD_dom
TH2_k127_7391732_7	497964.CfE428DRAFT_3053	3.024e-160	530.0	COG1139@1|root,COG1139@2|Bacteria,46SBN@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Domain of unknown function (DUF3390)	-	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_8,LUD_dom
TH2_k127_7391732_18	525897.Dbac_1216	6.489e-73	252.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,42PNX@68525|delta/epsilon subdivisions,2WK8F@28221|Deltaproteobacteria,2M8X5@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Cysteine-rich domain	-	-	-	ko:K18928	-	-	-	-	ko00000	-	-	-	CCG
TH2_k127_7391732_2	452637.Oter_0818	4.456e-239	744.0	COG0334@1|root,COG0334@2|Bacteria,46UBX@74201|Verrucomicrobia,3K7SK@414999|Opitutae	414999|Opitutae	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	-	R00248	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
TH2_k127_7391732_1	1499967.BAYZ01000119_gene3213	3.01e-257	819.0	COG0574@1|root,COG0574@2|Bacteria	2|Bacteria	G	Belongs to the PEP-utilizing enzyme family	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PPDK_N
TH2_k127_7391732_23	478741.JAFS01000001_gene1228	2.782e-64	232.0	COG0767@1|root,COG0767@2|Bacteria,46SXR@74201|Verrucomicrobia,37GD9@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	Q	Permease MlaE	ttg2B	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
TH2_k127_7391732_14	1379698.RBG1_1C00001G0979	1.465e-83	293.0	COG1127@1|root,COG1127@2|Bacteria,2NP3U@2323|unclassified Bacteria	2|Bacteria	Q	ABC-type transport system involved in resistance to organic solvents, ATPase component	mkl	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
TH2_k127_7391732_34	638303.Thal_1386	5.624e-26	121.0	COG1463@1|root,COG1463@2|Bacteria,2G3I1@200783|Aquificae	200783|Aquificae	Q	Mammalian cell entry related domain protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
TH2_k127_7391732_11	452637.Oter_2116	1.49e-97	331.0	COG4956@1|root,COG4956@2|Bacteria,46TFJ@74201|Verrucomicrobia,3K8ZF@414999|Opitutae	414999|Opitutae	S	SMART Nucleotide binding protein PINc	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_7391732_16	880073.Calab_0342	2.68e-77	273.0	COG0501@1|root,COG0501@2|Bacteria,2NP9X@2323|unclassified Bacteria	2|Bacteria	O	CAAX prenyl protease N-terminal, five membrane helices	agmM	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
TH2_k127_7391732_25	497964.CfE428DRAFT_1801	9.162e-57	211.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	ywaD	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
TH2_k127_7391732_22	382464.ABSI01000013_gene1636	3.748e-65	235.0	COG0123@1|root,COG0123@2|Bacteria,46SMT@74201|Verrucomicrobia,2IUMK@203494|Verrucomicrobiae	203494|Verrucomicrobiae	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
TH2_k127_7391732_33	264201.pc0644	2.312e-29	119.0	COG0184@1|root,COG0184@2|Bacteria,2JG4W@204428|Chlamydiae	204428|Chlamydiae	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
TH2_k127_7391732_0	497964.CfE428DRAFT_3556	2.742e-277	870.0	COG1185@1|root,COG1185@2|Bacteria,46SBP@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
TH2_k127_7391732_35	1208321.D104_17525	1.301e-23	110.0	COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,1RQWT@1236|Gammaproteobacteria,1XJ6W@135619|Oceanospirillales	135619|Oceanospirillales	U	MotA TolQ ExbB proton channel	exbB1	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
TH2_k127_7391732_41	637390.AFOH01000039_gene2448	1.283e-06	56.0	COG0848@1|root,COG0848@2|Bacteria,1NE2R@1224|Proteobacteria,1T8ZG@1236|Gammaproteobacteria,2NDNT@225057|Acidithiobacillales	225057|Acidithiobacillales	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
TH2_k127_7391732_42	671143.DAMO_1914	1.498e-05	54.0	COG0848@1|root,COG0848@2|Bacteria,2NQ52@2323|unclassified Bacteria	2|Bacteria	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
TH2_k127_7391732_40	1125863.JAFN01000001_gene644	9.334e-08	66.0	COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,43CT2@68525|delta/epsilon subdivisions,2X80K@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
TH2_k127_7391732_27	497964.CfE428DRAFT_3663	2.137e-46	187.0	COG1657@1|root,COG1657@2|Bacteria,46V9U@74201|Verrucomicrobia	74201|Verrucomicrobia	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans
TH2_k127_7391732_10	234267.Acid_7187	8.267e-98	339.0	COG0457@1|root,COG0457@2|Bacteria,3Y3RA@57723|Acidobacteria	57723|Acidobacteria	M	SMART Tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8
TH2_k127_7391732_19	436114.SYO3AOP1_1494	1.602e-70	251.0	COG0258@1|root,COG0258@2|Bacteria,2G3XK@200783|Aquificae	200783|Aquificae	L	5'-3' exonuclease	-	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A
TH2_k127_7391732_9	497964.CfE428DRAFT_1451	5.543e-150	486.0	COG1459@1|root,COG1459@2|Bacteria,46S8P@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	type II secretion	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
TH2_k127_7391732_3	794903.OPIT5_27195	6.834e-213	675.0	COG2804@1|root,COG2804@2|Bacteria,46UFR@74201|Verrucomicrobia,3K7NA@414999|Opitutae	414999|Opitutae	NU	General secretory system II protein E domain protein	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
TH2_k127_7391732_8	313628.LNTAR_05914	1.501e-155	498.0	COG2805@1|root,COG2805@2|Bacteria	2|Bacteria	NU	Type II/IV secretion system protein	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
TH2_k127_7391732_4	497964.CfE428DRAFT_1457	1.257e-206	657.0	COG2804@1|root,COG2804@2|Bacteria,46SDR@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	General secretory system II protein E domain protein	pulE	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
TH2_k127_7391732_6	273068.TTE0608	5.957e-164	531.0	COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,247MS@186801|Clostridia,42F1D@68295|Thermoanaerobacterales	186801|Clostridia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
TH2_k127_7391732_5	478741.JAFS01000001_gene1191	6.44e-200	634.0	COG0154@1|root,COG0154@2|Bacteria,46SCM@74201|Verrucomicrobia,37FYA@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TH2_k127_7391732_36	497964.CfE428DRAFT_3411	1.212e-22	100.0	COG0721@1|root,COG0721@2|Bacteria,46TA2@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
TH2_k127_7391732_30	1396418.BATQ01000049_gene401	9.135e-33	135.0	COG3654@1|root,COG3654@2|Bacteria	2|Bacteria	-	-	doc	-	-	ko:K07341	-	-	-	-	ko00000,ko02048	-	-	-	Fic
TH2_k127_7391732_24	378806.STAUR_8028	2.404e-60	218.0	2EQ9M@1|root,33HVS@2|Bacteria,1NM3U@1224|Proteobacteria,431K7@68525|delta/epsilon subdivisions,2WX3B@28221|Deltaproteobacteria,2YWWT@29|Myxococcales	28221|Deltaproteobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_2
TH2_k127_7391732_15	313612.L8106_07606	5.685e-81	278.0	COG0500@1|root,COG2226@2|Bacteria,1G2V9@1117|Cyanobacteria	1117|Cyanobacteria	Q	PFAM sulfotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1
TH2_k127_7391732_28	102125.Xen7305DRAFT_00036350	8.68e-40	159.0	COG1020@1|root,COG1020@2|Bacteria,1G3S2@1117|Cyanobacteria,3VM13@52604|Pleurocapsales	1117|Cyanobacteria	Q	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	Condensation,PP-binding,Thioesterase
TH2_k127_7391732_17	756067.MicvaDRAFT_4426	1.399e-75	266.0	COG0500@1|root,COG2226@2|Bacteria,1G2V9@1117|Cyanobacteria,1HAFQ@1150|Oscillatoriales	1117|Cyanobacteria	Q	PFAM Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1
TH2_k127_7391732_13	696747.NIES39_J05240	1.118e-84	291.0	COG0438@1|root,COG0438@2|Bacteria,1G2PH@1117|Cyanobacteria,1HAF4@1150|Oscillatoriales	1117|Cyanobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_7391732_26	1122176.KB903619_gene5307	2.313e-48	183.0	2DKVZ@1|root,30IFS@2|Bacteria	2|Bacteria	S	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1,Sulfotransfer_3
TH2_k127_7392052_8	439235.Dalk_2288	5.311e-63	240.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,42R71@68525|delta/epsilon subdivisions,2WMW5@28221|Deltaproteobacteria,2MPW6@213118|Desulfobacterales	28221|Deltaproteobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF4150,RHS,RHS_repeat,Transglut_core
TH2_k127_7392052_1	452637.Oter_2571	2.214e-151	492.0	COG1092@1|root,COG1092@2|Bacteria,46UWW@74201|Verrucomicrobia,3K746@414999|Opitutae	414999|Opitutae	J	Met-10+ like-protein	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
TH2_k127_7392052_0	583355.Caka_2972	5.779e-200	641.0	COG0488@1|root,COG0488@2|Bacteria,46UUC@74201|Verrucomicrobia,3K79Q@414999|Opitutae	414999|Opitutae	S	PFAM ABC transporter related	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
TH2_k127_7392052_2	588581.Cpap_0224	2.118e-145	482.0	COG0541@1|root,COG0541@2|Bacteria,1TP06@1239|Firmicutes,248EU@186801|Clostridia,3WH5J@541000|Ruminococcaceae	186801|Clostridia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
TH2_k127_7392052_12	497964.CfE428DRAFT_2914	5.52e-23	106.0	COG0228@1|root,COG0228@2|Bacteria,46WC2@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
TH2_k127_7392052_13	768670.Calni_2010	1.687e-20	94.0	COG1837@1|root,COG1837@2|Bacteria,2GFZI@200930|Deferribacteres	200930|Deferribacteres	S	KH domain	-	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
TH2_k127_7392052_6	404380.Gbem_3428	2.006e-86	293.0	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,42P8R@68525|delta/epsilon subdivisions,2WKIR@28221|Deltaproteobacteria,43U24@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Methyltrn_RNA_4,tRNA_m1G_MT
TH2_k127_7392052_10	2325.TKV_c13730	8.272e-40	158.0	COG0335@1|root,COG0335@2|Bacteria,1V6FT@1239|Firmicutes,24J83@186801|Clostridia,42GJ8@68295|Thermoanaerobacterales	186801|Clostridia	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
TH2_k127_7392052_7	497964.CfE428DRAFT_0568	3.731e-69	241.0	COG0164@1|root,COG0164@2|Bacteria,46SXH@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
TH2_k127_7392052_11	439235.Dalk_4642	3.085e-28	121.0	COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,42VES@68525|delta/epsilon subdivisions,2WRSC@28221|Deltaproteobacteria,2MM4E@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
TH2_k127_7392052_14	1521187.JPIM01000043_gene1922	1.973e-07	64.0	COG3391@1|root,COG3391@2|Bacteria,2GBVS@200795|Chloroflexi,376ZB@32061|Chloroflexia	32061|Chloroflexia	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_7392052_3	497964.CfE428DRAFT_4028	3.028e-130	434.0	COG0728@1|root,COG0728@2|Bacteria,46SH1@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
TH2_k127_7392052_9	1340493.JNIF01000003_gene1519	1.522e-61	226.0	COG0859@1|root,COG0859@2|Bacteria,3Y3EJ@57723|Acidobacteria	57723|Acidobacteria	M	PFAM glycosyl transferase family 9	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
TH2_k127_7392052_4	794903.OPIT5_07775	1.795e-126	419.0	COG1663@1|root,COG1663@2|Bacteria,46SBI@74201|Verrucomicrobia,3K7KP@414999|Opitutae	414999|Opitutae	M	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
TH2_k127_7392052_5	1499967.BAYZ01000118_gene3300	1.703e-123	407.0	COG1454@1|root,COG1454@2|Bacteria,2NQ5W@2323|unclassified Bacteria	2|Bacteria	C	Iron-containing alcohol dehydrogenase	CT0951	-	1.1.1.1,4.3.3.7	ko:K00001,ko:K01714,ko:K13954	ko00010,ko00071,ko00261,ko00300,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,ko01230,map00010,map00071,map00261,map00300,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220,map01230	M00016,M00525,M00526,M00527	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310,R10147	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273,RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	Fe-ADH
TH2_k127_740907_2	1286171.EAL2_808p04650	1.728e-52	190.0	COG1881@1|root,COG1881@2|Bacteria,1VB6M@1239|Firmicutes,24TUR@186801|Clostridia,25Z1K@186806|Eubacteriaceae	186801|Clostridia	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
TH2_k127_740907_1	794903.OPIT5_11650	4.278e-130	428.0	COG2081@1|root,COG2081@2|Bacteria,46TWE@74201|Verrucomicrobia,3K7FU@414999|Opitutae	414999|Opitutae	S	HI0933-like protein	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
TH2_k127_740907_0	266117.Rxyl_1110	2.057e-177	568.0	COG0281@1|root,COG0281@2|Bacteria,2GJAJ@201174|Actinobacteria,4CPBI@84995|Rubrobacteria	84995|Rubrobacteria	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	ACT_4,Malic_M,malic
TH2_k127_740907_3	1173023.KE650771_gene1836	4.696e-28	117.0	COG1262@1|root,COG2944@1|root,COG1262@2|Bacteria,COG2944@2|Bacteria,1G0ZT@1117|Cyanobacteria	1117|Cyanobacteria	D	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,TIR_2
TH2_k127_7503865_0	665956.HMPREF1032_00471	2.633e-101	346.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	3.1.3.5,3.6.1.45	ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Lipase_GDSL_2,Metallophos,SASA,SLH
TH2_k127_7509102_0	1226325.HMPREF1548_03574	3.061e-149	481.0	COG3669@1|root,COG3669@2|Bacteria,1TQH2@1239|Firmicutes,24B8Y@186801|Clostridia,36F4D@31979|Clostridiaceae	186801|Clostridia	G	Psort location Cytoplasmic, score 7.50	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
TH2_k127_7509102_1	478741.JAFS01000002_gene378	2.412e-23	116.0	COG0457@1|root,COG1196@1|root,COG0457@2|Bacteria,COG1196@2|Bacteria,46T1H@74201|Verrucomicrobia,37G9U@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	D	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_2
TH2_k127_7525680_2	243231.GSU0636	2.583e-14	83.0	COG5617@1|root,COG5617@2|Bacteria,1QXN8@1224|Proteobacteria,431TV@68525|delta/epsilon subdivisions,2X7EP@28221|Deltaproteobacteria,43TUV@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
TH2_k127_7525680_1	761193.Runsl_0860	4.168e-98	331.0	COG1028@1|root,COG1028@2|Bacteria,4NHVK@976|Bacteroidetes,47K2F@768503|Cytophagia	976|Bacteroidetes	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TH2_k127_7525680_0	1267535.KB906767_gene5170	2.217e-129	415.0	COG0673@1|root,COG0673@2|Bacteria,3Y7D9@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TH2_k127_7537340_21	1403819.BATR01000062_gene1902	0.0002964	44.0	COG0520@1|root,COG0520@2|Bacteria,46SC0@74201|Verrucomicrobia,2IW1B@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TH2_k127_7537340_17	572479.Hprae_0758	1.403e-21	96.0	COG0227@1|root,COG0227@2|Bacteria,1UH8Z@1239|Firmicutes,25PYQ@186801|Clostridia,3WC13@53433|Halanaerobiales	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
TH2_k127_7537340_11	335543.Sfum_0568	1.444e-60	224.0	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,42RVN@68525|delta/epsilon subdivisions,2WNJW@28221|Deltaproteobacteria,2MS17@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	SurA N-terminal domain	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
TH2_k127_7537340_1	886293.Sinac_4412	2.77e-210	684.0	COG1216@1|root,COG3250@1|root,COG1216@2|Bacteria,COG3250@2|Bacteria,2J0NC@203682|Planctomycetes	203682|Planctomycetes	G	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TH2_k127_7537340_2	489825.LYNGBM3L_21210	6.014e-186	604.0	COG1132@1|root,COG1132@2|Bacteria,1G1JY@1117|Cyanobacteria,1H7BU@1150|Oscillatoriales	1117|Cyanobacteria	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TH2_k127_7537340_3	489825.LYNGBM3L_21200	9.524e-178	575.0	COG1132@1|root,COG1132@2|Bacteria,1G1JY@1117|Cyanobacteria,1H7BU@1150|Oscillatoriales	1117|Cyanobacteria	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TH2_k127_7537340_14	1454004.AW11_02488	2.891e-46	181.0	COG0394@1|root,COG0704@1|root,COG0394@2|Bacteria,COG0704@2|Bacteria	2|Bacteria	P	negative regulation of phosphate transmembrane transport	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	1.20.4.1,3.1.3.48	ko:K01104,ko:K02039,ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	PhoU
TH2_k127_7537340_9	517418.Ctha_0917	1.224e-105	351.0	COG0226@1|root,COG0226@2|Bacteria,1FE4N@1090|Chlorobi	1090|Chlorobi	P	TIGRFAM phosphate binding protein	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
TH2_k127_7537340_4	517418.Ctha_0918	2.063e-137	442.0	COG0573@1|root,COG0573@2|Bacteria,1FE1M@1090|Chlorobi	1090|Chlorobi	P	TIGRFAM phosphate ABC transporter, inner membrane subunit PstC	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
TH2_k127_7537340_6	517418.Ctha_0919	3.124e-124	411.0	COG0581@1|root,COG0581@2|Bacteria,1FE3G@1090|Chlorobi	1090|Chlorobi	P	TIGRFAM phosphate ABC transporter, inner membrane subunit PstA	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
TH2_k127_7537340_8	517418.Ctha_0920	6.225e-112	371.0	COG1117@1|root,COG1117@2|Bacteria	2|Bacteria	P	ATPase-coupled phosphate ion transmembrane transporter activity	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
TH2_k127_7537340_7	517418.Ctha_0921	1.243e-119	390.0	COG1117@1|root,COG1117@2|Bacteria,1FEHB@1090|Chlorobi	1090|Chlorobi	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
TH2_k127_7537340_10	1131462.DCF50_p2803	1.343e-104	362.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,260MY@186807|Peptococcaceae	186801|Clostridia	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_8,sCache_like
TH2_k127_7537340_20	1123508.JH636443_gene4875	9.677e-05	52.0	COG0457@1|root,COG0457@2|Bacteria,2J0KQ@203682|Planctomycetes	203682|Planctomycetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_7537340_5	452637.Oter_0935	1.38e-130	427.0	COG0042@1|root,COG0042@2|Bacteria,46TCT@74201|Verrucomicrobia,3K895@414999|Opitutae	414999|Opitutae	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	-	-	-	-	-	-	-	-	-	-	-	-	Dus
TH2_k127_7537340_12	1396141.BATP01000032_gene4366	7.544e-51	184.0	COG0346@1|root,COG0346@2|Bacteria,46SUF@74201|Verrucomicrobia,2IUKG@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TH2_k127_7537340_19	1408422.JHYF01000006_gene1065	2.702e-12	80.0	COG0265@1|root,COG0265@2|Bacteria,1TRM8@1239|Firmicutes,247M5@186801|Clostridia,36DM2@31979|Clostridiaceae	186801|Clostridia	O	PDZ DHR GLGF domain protein	htrA	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
TH2_k127_7537340_18	1112216.JH594425_gene2382	3.198e-14	87.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,2K08H@204457|Sphingomonadales	204457|Sphingomonadales	M	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
TH2_k127_7537340_13	335543.Sfum_2005	4.773e-48	188.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2MQB7@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
TH2_k127_7537340_16	641491.DND132_0611	1.785e-27	122.0	COG1259@1|root,COG1259@2|Bacteria,1RFFV@1224|Proteobacteria,42SCI@68525|delta/epsilon subdivisions,2WPWT@28221|Deltaproteobacteria,2M8KC@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
TH2_k127_7537340_15	497964.CfE428DRAFT_4835	3.873e-37	143.0	COG4747@1|root,COG4747@2|Bacteria,46WIS@74201|Verrucomicrobia	74201|Verrucomicrobia	S	ACT domain	-	-	-	-	-	-	-	-	-	-	-	-	ACT
TH2_k127_7537340_0	794903.OPIT5_28125	0.0	1105.0	COG3808@1|root,COG3808@2|Bacteria,46S7R@74201|Verrucomicrobia,3K82Q@414999|Opitutae	414999|Opitutae	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
TH2_k127_7623881_10	391937.NA2_08976	4.934e-05	48.0	COG1451@1|root,COG1451@2|Bacteria,1MXZU@1224|Proteobacteria,2U1JG@28211|Alphaproteobacteria,43H7T@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function DUF45	MA20_23375	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
TH2_k127_7623881_8	452637.Oter_4236	1.906e-15	79.0	2EIJD@1|root,33CAP@2|Bacteria,46WH7@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_7623881_4	497964.CfE428DRAFT_2111	3.045e-92	313.0	COG5285@1|root,COG5285@2|Bacteria,46UDZ@74201|Verrucomicrobia	74201|Verrucomicrobia	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
TH2_k127_7623881_9	1502852.FG94_00145	6.55e-07	53.0	2CJ8Z@1|root,32WUG@2|Bacteria,1N1PS@1224|Proteobacteria,2VUYW@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_7623881_3	518766.Rmar_1528	4.465e-112	374.0	2BXG3@1|root,2Z82R@2|Bacteria,4NI3Z@976|Bacteroidetes	976|Bacteroidetes	S	tagaturonate epimerase	-	-	5.1.2.7	ko:K21619	ko00040,ko01100,map00040,map01100	-	R11624	-	ko00000,ko00001,ko01000	-	-	-	UxaE
TH2_k127_7623881_5	497964.CfE428DRAFT_5038	3.325e-91	314.0	COG1520@1|root,COG1520@2|Bacteria,46T0C@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM Pyrrolo-quinoline quinone	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_3
TH2_k127_7623881_0	497964.CfE428DRAFT_2602	2.492e-167	538.0	COG1508@1|root,COG1508@2|Bacteria,46SDZ@74201|Verrucomicrobia	74201|Verrucomicrobia	K	TIGRFAM RNA polymerase sigma-54 factor, RpoN	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
TH2_k127_7623881_6	497964.CfE428DRAFT_6105	8.603e-77	266.0	COG1235@1|root,COG1235@2|Bacteria,46SKU@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TH2_k127_7623881_1	886293.Sinac_5112	5.668e-145	467.0	COG0686@1|root,COG0686@2|Bacteria,2IXPP@203682|Planctomycetes	203682|Planctomycetes	C	Belongs to the AlaDH PNT family	-	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
TH2_k127_7623881_2	1259795.ARJK01000003_gene830	3.792e-138	459.0	COG1966@1|root,COG1966@2|Bacteria,1TQN8@1239|Firmicutes,248DZ@186801|Clostridia,42EYM@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM Carbon starvation protein CstA	-	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
TH2_k127_7683573_5	1121428.DESHY_60206___1	1.897e-63	228.0	COG0083@1|root,COG0083@2|Bacteria,1TRWS@1239|Firmicutes,248NA@186801|Clostridia,26127@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	-	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS03525	GHMP_kinases_C,GHMP_kinases_N
TH2_k127_7683573_4	583355.Caka_1356	5.887e-66	237.0	COG0564@1|root,COG0564@2|Bacteria,46W71@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Belongs to the pseudouridine synthase RluA family	-	-	-	-	-	-	-	-	-	-	-	-	PseudoU_synth_2
TH2_k127_7683573_3	497964.CfE428DRAFT_5455	1.01e-66	234.0	COG2344@1|root,COG2344@2|Bacteria	2|Bacteria	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
TH2_k127_7683573_0	926561.KB900617_gene1873	1.055e-115	396.0	COG4666@1|root,COG4666@2|Bacteria,1TP0V@1239|Firmicutes,248AI@186801|Clostridia,3WB2B@53433|Halanaerobiales	186801|Clostridia	S	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
TH2_k127_7683573_6	1123250.KB908379_gene1119	1.421e-55	207.0	COG2358@1|root,COG2358@2|Bacteria,1TPXW@1239|Firmicutes,4H2B2@909932|Negativicutes	909932|Negativicutes	S	TRAP transporter solute receptor TAXI family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
TH2_k127_7683573_1	518766.Rmar_0087	3.948e-92	312.0	2BYH3@1|root,2Z7SZ@2|Bacteria,4P1K1@976|Bacteroidetes	976|Bacteroidetes	S	3-methyladenine DNA glycosylase	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_7683573_2	926550.CLDAP_31570	5.262e-80	284.0	COG0673@1|root,COG0673@2|Bacteria,2G6KB@200795|Chloroflexi	200795|Chloroflexi	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TH2_k127_7683573_7	1211813.CAPH01000001_gene1170	3.168e-45	172.0	COG3345@1|root,COG3345@2|Bacteria,4NZUR@976|Bacteroidetes,2FNUD@200643|Bacteroidia	976|Bacteroidetes	G	Melibiase	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Melibiase
TH2_k127_7689526_6	997352.HMPREF9419_1034	2.328e-25	107.0	COG1262@1|root,COG1262@2|Bacteria,4NJC9@976|Bacteroidetes,2G2PW@200643|Bacteroidia	976|Bacteroidetes	G	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2,FGE-sulfatase
TH2_k127_7689526_0	1173028.ANKO01000112_gene4787	1.589e-275	869.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1GBMT@1117|Cyanobacteria,1HE9H@1150|Oscillatoriales	1117|Cyanobacteria	GT	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
TH2_k127_7689526_4	1173028.ANKO01000112_gene4788	5.871e-107	359.0	COG0382@1|root,COG0382@2|Bacteria,1GBH5@1117|Cyanobacteria,1HE6Y@1150|Oscillatoriales	1117|Cyanobacteria	H	UbiA prenyltransferase family	-	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
TH2_k127_7689526_2	1042163.BRLA_c023930	4.306e-153	496.0	COG1257@1|root,COG1257@2|Bacteria,1VWYW@1239|Firmicutes	1239|Firmicutes	I	Hydroxymethylglutaryl-coenzyme A reductase	-	-	1.1.1.34	ko:K00021	ko00900,ko01100,ko01110,ko01130,ko04152,ko04976,map00900,map01100,map01110,map01130,map04152,map04976	M00095	R02082	RC00004,RC00644	ko00000,ko00001,ko00002,ko01000	-	-	-	HMG-CoA_red
TH2_k127_7689526_3	1123242.JH636435_gene1594	4.687e-137	457.0	COG1032@1|root,COG1032@2|Bacteria,2IYYP@203682|Planctomycetes	203682|Planctomycetes	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
TH2_k127_7689526_5	522306.CAP2UW1_4251	3.094e-27	117.0	2EBIG@1|root,335IZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_7689526_7	1484158.PSNIH1_05960	1.758e-05	52.0	COG5645@1|root,COG5645@2|Bacteria,1MZ8R@1224|Proteobacteria,1S9TX@1236|Gammaproteobacteria,3W0V0@53335|Pantoea	1236|Gammaproteobacteria	S	lipoprotein	yidQ	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716	-	-	-	-	-	-	-	-	-	-	DUF1375
TH2_k127_7689526_1	335543.Sfum_2866	5.751e-174	559.0	COG2204@1|root,COG2204@2|Bacteria,1QYWF@1224|Proteobacteria,43CD6@68525|delta/epsilon subdivisions,2X7P0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Sigma54_activat
TH2_k127_7689526_8	1396418.BATQ01000078_gene621	0.0009561	48.0	COG2165@1|root,COG2165@2|Bacteria,46T9D@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
TH2_k127_78033_4	1255043.TVNIR_2321	2.339e-73	265.0	COG3385@1|root,COG3385@2|Bacteria,1MXYG@1224|Proteobacteria,1S0CA@1236|Gammaproteobacteria,1WXQT@135613|Chromatiales	135613|Chromatiales	L	Transposase IS4 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4338,Dimer_Tnp_Tn5,Tnp_DNA_bind
TH2_k127_78033_8	1255043.TVNIR_2439	1.551e-57	211.0	COG3385@1|root,COG3385@2|Bacteria,1MXYG@1224|Proteobacteria,1S0CA@1236|Gammaproteobacteria,1WXQT@135613|Chromatiales	135613|Chromatiales	L	Transposase IS4 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4338,Dimer_Tnp_Tn5,Tnp_DNA_bind
TH2_k127_78033_15	1396418.BATQ01000189_gene762	4.34e-19	91.0	COG3344@1|root,COG3344@2|Bacteria,46TQ6@74201|Verrucomicrobia	74201|Verrucomicrobia	L	PFAM RNA-directed DNA polymerase (Reverse transcriptase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
TH2_k127_78033_6	717231.Flexsi_1092	1.274e-62	226.0	COG0345@1|root,COG0345@2|Bacteria,2GERX@200930|Deferribacteres	200930|Deferribacteres	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
TH2_k127_78033_5	497964.CfE428DRAFT_2158	5.486e-63	226.0	COG0325@1|root,COG0325@2|Bacteria,46SV2@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
TH2_k127_78033_10	1156937.MFUM_920020	1.781e-39	157.0	2AG58@1|root,3169Z@2|Bacteria,46WMP@74201|Verrucomicrobia,37GPD@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_78033_13	481448.Minf_0272	4.18e-33	137.0	2CK2Q@1|root,30XDX@2|Bacteria,46X4H@74201|Verrucomicrobia,37HA6@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_78033_17	555779.Dthio_PD0504	6.163e-12	71.0	COG5433@1|root,COG5433@2|Bacteria,1MXB5@1224|Proteobacteria,431TI@68525|delta/epsilon subdivisions,2WWAP@28221|Deltaproteobacteria,2MB98@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	DDE_Tnp_1-associated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc,DUF4338
TH2_k127_78033_14	497964.CfE428DRAFT_3409	1.04e-22	107.0	2FHDV@1|root,34981@2|Bacteria,46W9B@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_78033_12	330214.NIDE4328	2.086e-33	138.0	COG0350@1|root,COG0350@2|Bacteria,3J1A8@40117|Nitrospirae	40117|Nitrospirae	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	-	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1
TH2_k127_78033_0	452637.Oter_2454	3.297e-185	594.0	COG0659@1|root,COG0659@2|Bacteria,46THR@74201|Verrucomicrobia,3K7K8@414999|Opitutae	414999|Opitutae	P	Sulfate transporter antisigma-factor antagonist STAS	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
TH2_k127_78033_3	324925.Ppha_0671	2.165e-77	275.0	COG3074@1|root,COG3074@2|Bacteria,1FFHR@1090|Chlorobi	1090|Chlorobi	D	FtsZ-dependent cytokinesis	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_78033_11	1123354.AUDR01000013_gene828	2.053e-33	132.0	COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,2VH45@28216|Betaproteobacteria,1KSVI@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Sulfate permease family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
TH2_k127_78033_1	635013.TherJR_1041	2.191e-119	397.0	COG2223@1|root,COG2223@2|Bacteria,1TPR9@1239|Firmicutes,2483N@186801|Clostridia,260AH@186807|Peptococcaceae	186801|Clostridia	P	PFAM Major Facilitator Superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
TH2_k127_78033_7	313628.LNTAR_08349	1.273e-59	220.0	COG0472@1|root,COG0472@2|Bacteria	313628.LNTAR_08349|-	M	phospho-N-acetylmuramoyl-pentapeptide-transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_78033_2	521674.Plim_4161	1.675e-106	357.0	COG0438@1|root,COG0438@2|Bacteria,2IXN1@203682|Planctomycetes	203682|Planctomycetes	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TH2_k127_78033_9	497964.CfE428DRAFT_4099	2.586e-53	202.0	28JRZ@1|root,2Z9HI@2|Bacteria,46TRU@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function (DUF4126)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4126
TH2_k127_78033_16	1123242.JH636435_gene1254	3.464e-17	96.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	Abhydrolase_3,COesterase,Esterase,Peptidase_S9
TH2_k127_78033_18	1313172.YM304_25360	5.076e-06	51.0	COG1994@1|root,COG1994@2|Bacteria,2GJBZ@201174|Actinobacteria	201174|Actinobacteria	M	Belongs to the peptidase M50B family	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
TH2_k127_7819134_4	945713.IALB_2814	2.109e-47	173.0	COG5557@1|root,COG5557@2|Bacteria	2|Bacteria	C	Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
TH2_k127_7819134_0	1191523.MROS_1076	0.0	1524.0	COG0243@1|root,COG0243@2|Bacteria	2|Bacteria	C	molybdopterin cofactor binding	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
TH2_k127_7819134_5	883096.HMPREF9699_01815	1.979e-10	62.0	COG1826@1|root,COG1826@2|Bacteria,4NUNH@976|Bacteroidetes,1I54R@117743|Flavobacteriia	976|Bacteroidetes	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
TH2_k127_7819134_1	497964.CfE428DRAFT_0160	1.044e-181	587.0	COG1657@1|root,COG1657@2|Bacteria,46UEC@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Squalene-hopene cyclase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans,SQHop_cyclase_C
TH2_k127_7819134_2	1396418.BATQ01000175_gene2764	1.333e-97	329.0	COG5029@1|root,COG5029@2|Bacteria,46URI@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Prenyltransferase and squalene oxidase repeat	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans
TH2_k127_7819134_6	290317.Cpha266_2437	2.742e-09	70.0	COG5617@1|root,COG5617@2|Bacteria,1FDV6@1090|Chlorobi	1090|Chlorobi	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
TH2_k127_7825115_1	330214.NIDE2536	2.964e-118	389.0	COG0021@1|root,COG0021@2|Bacteria,3J0MM@40117|Nitrospirae	40117|Nitrospirae	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
TH2_k127_7825115_0	497964.CfE428DRAFT_2352	2.225e-137	443.0	COG0502@1|root,COG0502@2|Bacteria,46S63@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
TH2_k127_7836659_1	1396418.BATQ01000137_gene3881	1.021e-29	122.0	2EHW5@1|root,33BMQ@2|Bacteria,46WAC@74201|Verrucomicrobia,2IWH5@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_7836659_0	1121904.ARBP01000025_gene6118	7.623e-189	608.0	COG1874@1|root,COG1874@2|Bacteria,4NK6M@976|Bacteroidetes,47MV4@768503|Cytophagia	976|Bacteroidetes	G	Beta-galactosidase trimerisation domain	-	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_42,Glyco_hydro_42M
TH2_k127_7838360_7	1304880.JAGB01000003_gene1278	6.313e-139	453.0	COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia	186801|Clostridia	G	hydrolase, family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
TH2_k127_7838360_17	1403819.BATR01000126_gene4520	5.557e-10	72.0	2CK49@1|root,2ZE58@2|Bacteria,46WV3@74201|Verrucomicrobia,2IW84@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_7838360_10	670487.Ocepr_1411	1.032e-101	337.0	COG0396@1|root,COG0396@2|Bacteria,1WIF0@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	COG0396 ABC-type transport system involved in Fe-S cluster assembly ATPase component	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
TH2_k127_7838360_2	926550.CLDAP_20350	4.11e-182	580.0	COG0719@1|root,COG0719@2|Bacteria,2G5TI@200795|Chloroflexi	200795|Chloroflexi	O	TIGRFAM FeS assembly protein SufB	sufB	-	-	ko:K07033,ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
TH2_k127_7838360_13	479434.Sthe_1524	5.402e-79	279.0	COG0719@1|root,COG0719@2|Bacteria,2G5S8@200795|Chloroflexi,27Y27@189775|Thermomicrobia	189775|Thermomicrobia	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
TH2_k127_7838360_5	926550.CLDAP_20370	8.092e-163	528.0	COG0520@1|root,COG0520@2|Bacteria,2G5T3@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
TH2_k127_7838360_1	1396418.BATQ01000156_gene5588	3.102e-218	686.0	COG2115@1|root,COG2115@2|Bacteria,46TT2@74201|Verrucomicrobia,2ITJ2@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_7838360_4	1403819.BATR01000169_gene5806	4.618e-168	542.0	COG1190@1|root,COG1190@2|Bacteria,46TIA@74201|Verrucomicrobia,2ITHH@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	tRNA synthetases class II (D, K and N)	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
TH2_k127_7838360_11	478741.JAFS01000002_gene233	2.125e-94	324.0	COG4591@1|root,COG4591@2|Bacteria,46SKZ@74201|Verrucomicrobia,37G6B@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	MacB-like periplasmic core domain	lolE	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
TH2_k127_7838360_14	330214.NIDE2051	2.358e-67	237.0	COG1136@1|root,COG1136@2|Bacteria,3J0IT@40117|Nitrospirae	40117|Nitrospirae	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
TH2_k127_7838360_9	278957.ABEA03000060_gene3151	7.119e-118	388.0	COG0115@1|root,COG0115@2|Bacteria,46S9W@74201|Verrucomicrobia,3K7I4@414999|Opitutae	414999|Opitutae	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
TH2_k127_7838360_15	497964.CfE428DRAFT_3441	1.93e-48	179.0	COG3880@1|root,COG3880@2|Bacteria,46SXX@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM UvrB UvrC protein	mcsA	-	-	ko:K19411	-	-	-	-	ko00000	-	-	-	UVR
TH2_k127_7838360_6	497964.CfE428DRAFT_3440	1.73e-142	461.0	COG3869@1|root,COG3869@2|Bacteria,46S55@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Protein-arginine kinase	mcsB	-	2.7.14.1	ko:K19405	-	-	R11090	RC00002,RC00203	ko00000,ko01000	-	-	-	ATP-gua_Ptrans
TH2_k127_7838360_0	1396418.BATQ01000168_gene1810	0.0	1154.0	COG0542@1|root,COG0542@2|Bacteria,46SD6@74201|Verrucomicrobia,2ITPB@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
TH2_k127_7838360_3	1380394.JADL01000008_gene3518	1.426e-169	547.0	COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,2TTDT@28211|Alphaproteobacteria,2JPTS@204441|Rhodospirillales	204441|Rhodospirillales	G	D-galactarate dehydratase / Altronate hydrolase, C terminus	-	-	4.2.1.7	ko:K01685	ko00040,ko01100,map00040,map01100	M00631	R01540	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C,SAF
TH2_k127_7838360_8	1123070.KB899247_gene1576	2.608e-121	399.0	COG0077@1|root,COG0077@2|Bacteria,46U8V@74201|Verrucomicrobia,2ITT8@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Chorismate mutase type II	-	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
TH2_k127_7838360_16	1396141.BATP01000005_gene5950	9.299e-42	163.0	COG1386@1|root,COG1386@2|Bacteria,46VRU@74201|Verrucomicrobia,2IUTS@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Segregation and condensation complex subunit ScpB	-	-	-	-	-	-	-	-	-	-	-	-	SMC_ScpB
TH2_k127_7838360_12	497964.CfE428DRAFT_5017	3.083e-80	274.0	COG1354@1|root,COG1354@2|Bacteria,46UBD@74201|Verrucomicrobia	74201|Verrucomicrobia	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	-	-	-	-	-	-	-	-	-	-	-	-	SMC_ScpA
TH2_k127_7858687_1	330214.NIDE1873	5.356e-128	445.0	COG2982@1|root,COG2982@2|Bacteria	2|Bacteria	M	Protein involved in outer membrane biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	DUF748,OmpA
TH2_k127_7858687_3	392499.Swit_1218	1.645e-41	169.0	COG3014@1|root,COG3014@2|Bacteria,1RA9U@1224|Proteobacteria,2U5MF@28211|Alphaproteobacteria,2KAH5@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_7858687_4	452637.Oter_1490	1.047e-27	122.0	COG3417@1|root,COG3417@2|Bacteria	2|Bacteria	M	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)	-	-	-	ko:K07337	-	-	-	-	ko00000	-	-	-	LpoB
TH2_k127_7858687_0	338969.Rfer_1098	8.824e-129	424.0	COG0475@1|root,COG0475@2|Bacteria,1MVGV@1224|Proteobacteria,2VJ0E@28216|Betaproteobacteria,4AEN9@80864|Comamonadaceae	28216|Betaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
TH2_k127_7858687_2	378806.STAUR_7863	2.384e-77	265.0	COG4894@1|root,COG4894@2|Bacteria,1RKPJ@1224|Proteobacteria,434XW@68525|delta/epsilon subdivisions,2WZ8Q@28221|Deltaproteobacteria,2Z1KE@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_7870252_0	1403819.BATR01000162_gene5398	1.302e-268	840.0	COG0488@1|root,COG0488@2|Bacteria,46SJA@74201|Verrucomicrobia,2ITVQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	ABC transporter C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
TH2_k127_7870252_2	794903.OPIT5_18660	1.455e-80	286.0	COG1538@1|root,COG1538@2|Bacteria,46T0P@74201|Verrucomicrobia,3K73I@414999|Opitutae	414999|Opitutae	MU	PFAM outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TH2_k127_7870252_3	1156937.MFUM_700081	1.708e-43	168.0	COG1496@1|root,COG1496@2|Bacteria,46STZ@74201|Verrucomicrobia,37GQK@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Multi-copper polyphenol oxidoreductase laccase	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
TH2_k127_7870252_1	1210884.HG799466_gene13039	1.504e-105	358.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
TH2_k127_7889120_1	1294265.JCM21738_4551	3.317e-36	146.0	COG0822@1|root,COG0822@2|Bacteria,1V3H9@1239|Firmicutes,4HIJ0@91061|Bacilli,1ZFQ8@1386|Bacillus	91061|Bacilli	C	COG0822 NifU homolog involved in Fe-S cluster formation	nifU	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0030003,GO:0036455,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0097428,GO:0098771,GO:1901564	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
TH2_k127_7889120_3	1379698.RBG1_1C00001G0819	2.224e-19	93.0	COG4911@1|root,COG4911@2|Bacteria,2NQ4H@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterized conserved protein (DUF2203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2203
TH2_k127_7889120_0	856793.MICA_372	2.179e-46	176.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,2TS4C@28211|Alphaproteobacteria,4BQ29@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TH2_k127_7889120_2	1301098.PKB_4840	3.011e-22	106.0	COG1917@1|root,COG4977@1|root,COG1917@2|Bacteria,COG4977@2|Bacteria,1MVS8@1224|Proteobacteria,1RQ3Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose	araC	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006355,GO:0008150,GO:0008152,GO:0009056,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016052,GO:0019219,GO:0019222,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0042802,GO:0043565,GO:0044212,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046365,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901575,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141	-	ko:K02099	-	-	-	-	ko00000,ko03000	-	-	-	AraC_binding,HTH_18,HTH_AraC
TH2_k127_7894348_2	696369.KI912183_gene1371	1.003e-78	274.0	COG3875@1|root,COG3875@2|Bacteria,1TQ1C@1239|Firmicutes,247PH@186801|Clostridia,261WJ@186807|Peptococcaceae	186801|Clostridia	S	conserved protein (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
TH2_k127_7894348_1	1122132.AQYH01000004_gene1480	1.296e-98	331.0	COG3618@1|root,COG3618@2|Bacteria,1P5PT@1224|Proteobacteria,2U3BR@28211|Alphaproteobacteria,4B7I8@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	metal-dependent hydrolase of the TIM-barrel fold	-	-	-	ko:K07046	ko00051,ko01120,map00051,map01120	-	R10689	RC00537	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
TH2_k127_7894348_4	134676.ACPL_4175	4.209e-65	235.0	COG1028@1|root,COG1028@2|Bacteria,2IAK8@201174|Actinobacteria	201174|Actinobacteria	IQ	Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TH2_k127_7894348_0	661478.OP10G_2068	2.704e-112	376.0	COG1879@1|root,COG1879@2|Bacteria	2|Bacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K10559	ko02010,map02010	M00220	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.9	-	-	Peripla_BP_4
TH2_k127_7894348_3	661478.OP10G_2067	8.243e-69	248.0	COG1172@1|root,COG1172@2|Bacteria	2|Bacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10561	ko02010,map02010	M00220	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.9	-	-	BPD_transp_2
TH2_k127_7894348_5	661478.OP10G_2066	1.265e-44	166.0	COG1172@1|root,COG1172@2|Bacteria	2|Bacteria	G	Belongs to the binding-protein-dependent transport system permease family	rhaP	-	-	ko:K10560	ko02010,map02010	M00220	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.9	-	-	BPD_transp_2
TH2_k127_7894348_6	661478.OP10G_2066	6.146e-18	85.0	COG1172@1|root,COG1172@2|Bacteria	2|Bacteria	G	Belongs to the binding-protein-dependent transport system permease family	rhaP	-	-	ko:K10560	ko02010,map02010	M00220	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.9	-	-	BPD_transp_2
TH2_k127_7895846_2	344747.PM8797T_28969	3.215e-128	417.0	COG1131@1|root,COG1131@2|Bacteria,2IXVN@203682|Planctomycetes	203682|Planctomycetes	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TH2_k127_7895846_1	240016.ABIZ01000001_gene3247	3.931e-146	471.0	COG0075@1|root,COG0075@2|Bacteria,46SCI@74201|Verrucomicrobia,2IU5S@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TH2_k127_7895846_0	697281.Mahau_0732	2.468e-148	479.0	COG0673@1|root,COG0673@2|Bacteria,1TSWE@1239|Firmicutes,24DSM@186801|Clostridia,42EM5@68295|Thermoanaerobacterales	186801|Clostridia	S	Oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TH2_k127_7895846_3	452637.Oter_2550	2.437e-82	279.0	COG0745@1|root,COG0745@2|Bacteria,46SS3@74201|Verrucomicrobia,3K7XM@414999|Opitutae	414999|Opitutae	K	Two component transcriptional regulator, winged helix family	-	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TH2_k127_7895846_4	497964.CfE428DRAFT_5668	4.305e-35	138.0	COG0457@1|root,COG0457@2|Bacteria,46V4J@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_8
TH2_k127_7899452_45	1403819.BATR01000098_gene3237	2.767e-05	51.0	2EHW5@1|root,33BMQ@2|Bacteria,46WAC@74201|Verrucomicrobia,2IWH5@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_7899452_36	1396141.BATP01000045_gene1775	1.938e-29	123.0	COG0838@1|root,COG0838@2|Bacteria,46T33@74201|Verrucomicrobia,2IUK0@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
TH2_k127_7899452_18	497964.CfE428DRAFT_3884	1.368e-80	272.0	COG0377@1|root,COG0377@2|Bacteria,46SMM@74201|Verrucomicrobia	74201|Verrucomicrobia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
TH2_k127_7899452_28	497964.CfE428DRAFT_3883	5.238e-51	197.0	COG0852@1|root,COG0852@2|Bacteria,46STM@74201|Verrucomicrobia	74201|Verrucomicrobia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
TH2_k127_7899452_3	497964.CfE428DRAFT_0519	7.128e-189	597.0	COG0649@1|root,COG0649@2|Bacteria,46SA0@74201|Verrucomicrobia	74201|Verrucomicrobia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
TH2_k127_7899452_2	497964.CfE428DRAFT_0527	5.132e-223	706.0	COG1894@1|root,COG1894@2|Bacteria,46S8J@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
TH2_k127_7899452_27	227377.CBU_1788	5.458e-54	196.0	COG0449@1|root,COG0449@2|Bacteria,1RGWX@1224|Proteobacteria,1SPE9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	ORF6N domain	-	-	-	-	-	-	-	-	-	-	-	-	ORF6N
TH2_k127_7899452_4	497964.CfE428DRAFT_0528	8.09e-179	576.0	COG1034@1|root,COG3383@1|root,COG1034@2|Bacteria,COG3383@2|Bacteria,46S6S@74201|Verrucomicrobia	74201|Verrucomicrobia	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3
TH2_k127_7899452_11	1403819.BATR01000084_gene2444	1.28e-118	390.0	COG1005@1|root,COG1005@2|Bacteria,46SIJ@74201|Verrucomicrobia,2ITZ1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
TH2_k127_7899452_25	794903.OPIT5_14145	1.352e-63	223.0	COG1143@1|root,COG1143@2|Bacteria,46SNT@74201|Verrucomicrobia,3K7UR@414999|Opitutae	414999|Opitutae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
TH2_k127_7899452_38	1156937.MFUM_940009	4.883e-28	119.0	COG0839@1|root,COG0839@2|Bacteria,46T5P@74201|Verrucomicrobia,37GUV@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
TH2_k127_7899452_35	478741.JAFS01000002_gene662	8.694e-30	122.0	COG0713@1|root,COG0713@2|Bacteria,46SX4@74201|Verrucomicrobia,37GV9@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
TH2_k127_7899452_29	671143.DAMO_0425	2.546e-46	173.0	COG3646@1|root,COG3646@2|Bacteria	2|Bacteria	L	Phage regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	ORF6N
TH2_k127_7899452_7	349741.Amuc_1606	1.603e-161	530.0	COG1009@1|root,COG1009@2|Bacteria,46SDU@74201|Verrucomicrobia,2ITQ9@203494|Verrucomicrobiae	203494|Verrucomicrobiae	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
TH2_k127_7899452_39	1150621.SMUL_1315	3.875e-26	109.0	COG2929@1|root,COG2929@2|Bacteria,1N6QP@1224|Proteobacteria,42VMA@68525|delta/epsilon subdivisions,2YQAI@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Ribonuclease toxin, BrnT, of type II toxin-antitoxin system	-	-	-	ko:K09803	-	-	-	-	ko00000	-	-	-	BrnT_toxin
TH2_k127_7899452_41	671143.DAMO_0367	3.75e-13	74.0	2C6B2@1|root,335GA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_7899452_9	1262449.CP6013_1979	1.589e-128	428.0	COG1008@1|root,COG1008@2|Bacteria,1UHSH@1239|Firmicutes,24AAH@186801|Clostridia,36UKY@31979|Clostridiaceae	186801|Clostridia	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	nuoM	-	1.6.5.3	ko:K00342,ko:K05575	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TH2_k127_7899452_13	635013.TherJR_2028	1.235e-104	359.0	COG1007@1|root,COG1007@2|Bacteria,1TR55@1239|Firmicutes,25ED8@186801|Clostridia,25ZY3@186807|Peptococcaceae	186801|Clostridia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TH2_k127_7899452_33	583355.Caka_0186	2.083e-34	136.0	2CCSR@1|root,30U27@2|Bacteria,46Y6M@74201|Verrucomicrobia,3K9T2@414999|Opitutae	414999|Opitutae	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
TH2_k127_7899452_6	525904.Tter_0422	1.271e-169	546.0	COG0114@1|root,COG0114@2|Bacteria,2NS3X@2323|unclassified Bacteria	2|Bacteria	C	Fumarase C C-terminus	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
TH2_k127_7899452_0	717605.Theco_2421	0.0	1088.0	COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,4HAG1@91061|Bacilli,26QCH@186822|Paenibacillaceae	91061|Bacilli	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
TH2_k127_7899452_10	382464.ABSI01000011_gene3025	2.53e-123	404.0	COG1186@1|root,COG1186@2|Bacteria,46SAW@74201|Verrucomicrobia,2ITHK@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
TH2_k127_7899452_21	497964.CfE428DRAFT_6074	1.402e-72	253.0	COG0134@1|root,COG0134@2|Bacteria	2|Bacteria	E	indole-3-glycerol-phosphate synthase activity	trpC	GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0004640,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.48,4.2.1.20,5.3.1.24	ko:K01609,ko:K01696,ko:K13498	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722,R03508,R03509	RC00209,RC00210,RC00700,RC00701,RC00944,RC00945,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2494,iJN746.PP_0422,iPC815.YPO2205,iSBO_1134.SBO_1804,iSDY_1059.SDY_1330	IGPS,PRAI
TH2_k127_7899452_43	1337936.IJ00_23910	3.252e-11	76.0	COG0457@1|root,COG0457@2|Bacteria,1G1G9@1117|Cyanobacteria,1HKDX@1161|Nostocales	1117|Cyanobacteria	S	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_6,TPR_8
TH2_k127_7899452_31	497964.CfE428DRAFT_0221	3.02e-36	145.0	2EKW2@1|root,33EJK@2|Bacteria,46VZV@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_7899452_32	671143.DAMO_2768	1.913e-34	137.0	COG0071@1|root,COG0071@2|Bacteria,2NPWF@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the small heat shock protein (HSP20) family	hspA-1	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
TH2_k127_7899452_40	926550.CLDAP_06890	1.023e-25	111.0	COG2020@1|root,COG2020@2|Bacteria	2|Bacteria	O	methyltransferase activity	ste14	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
TH2_k127_7899452_12	1123070.KB899254_gene1284	4.466e-117	389.0	COG0160@1|root,COG0160@2|Bacteria,46UEH@74201|Verrucomicrobia,2IVU9@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Aminotransferase class-III	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
TH2_k127_7899452_19	448385.sce2577	1.403e-78	267.0	COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,42RT9@68525|delta/epsilon subdivisions,2WNJ0@28221|Deltaproteobacteria,2YWKZ@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	iAF987.Gmet_1658	Fer4_14,Radical_SAM
TH2_k127_7899452_22	1227352.C173_29081	1.372e-68	241.0	COG0657@1|root,COG0657@2|Bacteria,1UYVK@1239|Firmicutes,4HI79@91061|Bacilli,2759M@186822|Paenibacillaceae	91061|Bacilli	I	esterase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Peptidase_S9
TH2_k127_7899452_14	1403819.BATR01000019_gene641	7.395e-102	347.0	COG0845@1|root,COG0845@2|Bacteria,46SG8@74201|Verrucomicrobia	74201|Verrucomicrobia	M	HlyD family secretion protein	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_3
TH2_k127_7899452_8	935948.KE386494_gene413	2.749e-145	470.0	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,42F3H@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM ABC transporter related	msmX	-	3.6.3.20	ko:K05816,ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00198,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1,3.A.1.1.3	-	-	ABC_tran,TOBE,TOBE_2
TH2_k127_7899452_42	278957.ABEA03000077_gene2270	1.65e-12	76.0	COG2165@1|root,COG2165@2|Bacteria,46YFD@74201|Verrucomicrobia,3K9GA@414999|Opitutae	414999|Opitutae	NU	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
TH2_k127_7899452_26	1231241.Mc24_00475	3.574e-55	216.0	COG0863@1|root,COG2189@1|root,COG0863@2|Bacteria,COG2189@2|Bacteria,2GD2C@200918|Thermotogae	200918|Thermotogae	H	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.113,2.1.1.72	ko:K00571,ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
TH2_k127_7899452_15	439235.Dalk_2653	4.185e-91	314.0	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,42SS8@68525|delta/epsilon subdivisions,2WPMH@28221|Deltaproteobacteria,2MPU9@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
TH2_k127_7899452_20	1042163.BRLA_c017400	1.065e-72	268.0	COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,4HABP@91061|Bacilli,26TPG@186822|Paenibacillaceae	91061|Bacilli	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	punA	-	2.4.2.1,2.4.2.28	ko:K00772,ko:K03783	ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110	M00034	R01402,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
TH2_k127_7899452_17	1191523.MROS_0957	1.832e-81	290.0	COG0572@1|root,COG0572@2|Bacteria	2|Bacteria	F	uridine kinase	udk	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
TH2_k127_7899452_16	1123508.JH636440_gene2908	1.107e-83	282.0	COG0450@1|root,COG0450@2|Bacteria,2IZ3M@203682|Planctomycetes	203682|Planctomycetes	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
TH2_k127_7899452_23	481448.Minf_0075	1.996e-68	245.0	COG0616@1|root,COG0616@2|Bacteria,46SQ5@74201|Verrucomicrobia,37GCB@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	OU	Peptidase family S49	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
TH2_k127_7899452_5	880073.Calab_3125	2.33e-175	561.0	COG1690@1|root,COG1690@2|Bacteria,2NNVX@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the RtcB family	rtcB	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
TH2_k127_7899452_30	1396141.BATP01000021_gene137	7.41e-39	157.0	COG1595@1|root,COG1595@2|Bacteria,46V3R@74201|Verrucomicrobia,2IVSK@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TH2_k127_7899452_24	621372.ACIH01000229_gene2041	9.879e-65	229.0	COG0175@1|root,COG0175@2|Bacteria,1TSMI@1239|Firmicutes,4HA9E@91061|Bacilli,26SAA@186822|Paenibacillaceae	91061|Bacilli	EH	Belongs to the PAPS reductase family. CysH subfamily	cysH	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
TH2_k127_7899452_34	314345.SPV1_14254	2.612e-31	130.0	COG1977@1|root,COG1977@2|Bacteria,1N4Z0@1224|Proteobacteria	1224|Proteobacteria	H	Molybdopterin converting factor, small subunit	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
TH2_k127_7899452_37	278957.ABEA03000217_gene377	1.415e-28	122.0	COG1959@1|root,COG1959@2|Bacteria,46VNQ@74201|Verrucomicrobia,3K872@414999|Opitutae	414999|Opitutae	K	TIGRFAM transcriptional regulator, Rrf2 family	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
TH2_k127_7899452_1	635013.TherJR_0008	9.636e-234	742.0	COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,248AV@186801|Clostridia,260WQ@186807|Peptococcaceae	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
TH2_k127_7943935_8	1049564.TevJSym_al00400	8.005e-16	90.0	COG3203@1|root,COG4257@1|root,COG3203@2|Bacteria,COG4257@2|Bacteria,1QVA0@1224|Proteobacteria,1T5JG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	FG-GAP repeat	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP_2
TH2_k127_7943935_10	867845.KI911784_gene1260	1.973e-08	62.0	COG0823@1|root,COG1520@1|root,COG0823@2|Bacteria,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	ko:K03641,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.C.1.2	-	-	DUF11,HYR,PD40,PQQ_2,VCBS
TH2_k127_7943935_5	452637.Oter_4607	1.408e-54	201.0	COG3005@1|root,COG3005@2|Bacteria,46T0N@74201|Verrucomicrobia,3K8D9@414999|Opitutae	414999|Opitutae	C	TIGRFAM cytochrome c nitrate reductase, small subunit	-	-	-	ko:K15876	ko00910,ko01120,map00910,map01120	M00530	R05712	RC00176	ko00000,ko00001,ko00002	-	-	-	Cytochrom_NNT
TH2_k127_7943935_0	1121920.AUAU01000005_gene1080	2.905e-209	661.0	COG3303@1|root,COG3303@2|Bacteria	2|Bacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	nrfA	-	1.7.2.2	ko:K03385	ko00910,ko01120,ko05132,map00910,map01120,map05132	M00530	R05712	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_C552
TH2_k127_7943935_2	1403819.BATR01000169_gene5823	1.317e-89	310.0	COG3203@1|root,COG3203@2|Bacteria,46SY8@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
TH2_k127_7943935_7	1121448.DGI_1223	2.6e-16	91.0	COG1108@1|root,COG1321@1|root,COG1108@2|Bacteria,COG1321@2|Bacteria,1MVC2@1224|Proteobacteria,42MYM@68525|delta/epsilon subdivisions,2WPQS@28221|Deltaproteobacteria,2MA0U@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	ABC 3 transport family	-	-	-	ko:K09816,ko:K09819	ko02010,map02010	M00242,M00243	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
TH2_k127_7943935_4	237368.SCABRO_03161	1.456e-63	227.0	COG1121@1|root,COG1121@2|Bacteria,2IYC3@203682|Planctomycetes	203682|Planctomycetes	P	COG1121 ABC-type Mn Zn transport systems ATPase component	-	-	-	ko:K11607,ko:K11710	ko02010,map02010	M00317,M00319	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.7,3.A.1.15.9	-	-	ABC_tran
TH2_k127_7943935_6	1055815.AYYA01000040_gene15	5.929e-33	133.0	2CFUA@1|root,32S2G@2|Bacteria,1N66W@1224|Proteobacteria,1SA2Y@1236|Gammaproteobacteria,3NKYZ@468|Moraxellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_7943935_3	521674.Plim_2346	1.931e-75	264.0	COG4974@1|root,COG4974@2|Bacteria,2IX6A@203682|Planctomycetes	203682|Planctomycetes	D	Belongs to the 'phage' integrase family. XerC subfamily	-	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TH2_k127_7943935_1	640081.Dsui_0821	2.705e-194	630.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,2KUMN@206389|Rhodocyclales	206389|Rhodocyclales	L	DNA topoisomerase III	-	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	Topoisom_bac,Toprim,Toprim_Crpt
TH2_k127_7947679_2	583355.Caka_0360	6.367e-70	245.0	COG0524@1|root,COG0524@2|Bacteria,46TT7@74201|Verrucomicrobia,3K7V3@414999|Opitutae	2|Bacteria	G	pfkB family carbohydrate kinase	-	-	2.7.1.15,2.7.1.4	ko:K00847,ko:K00852	ko00030,ko00051,ko00500,ko00520,ko01100,map00030,map00051,map00500,map00520,map01100	-	R00760,R00867,R01051,R02750,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
TH2_k127_7947679_0	1254432.SCE1572_44285	1.303e-194	616.0	COG2723@1|root,COG2723@2|Bacteria,1MWG6@1224|Proteobacteria,42UR5@68525|delta/epsilon subdivisions,2WQET@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 1 family	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
TH2_k127_7947679_1	886293.Sinac_4605	7.121e-120	402.0	COG5434@1|root,COG5434@2|Bacteria	2|Bacteria	M	polygalacturonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Pectate_lyase_3
TH2_k127_7992955_2	680646.RMDY18_11290	3.565e-08	57.0	COG0204@1|root,COG0204@2|Bacteria,2GQVG@201174|Actinobacteria,1WCIB@1268|Micrococcaceae	201174|Actinobacteria	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TH2_k127_7992955_1	530564.Psta_1015	3.541e-17	87.0	COG0128@1|root,COG0128@2|Bacteria,2J54V@203682|Planctomycetes	203682|Planctomycetes	E	3-phosphoshikimate 1-carboxyvinyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_7992955_0	395961.Cyan7425_1835	1.483e-45	174.0	COG1748@1|root,COG1748@2|Bacteria,1G37A@1117|Cyanobacteria	1117|Cyanobacteria	E	Saccharopine dehydrogenase C-terminal domain	-	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
TH2_k127_8002817_2	1280689.AUJC01000010_gene1859	2.979e-109	377.0	COG2268@1|root,COG2268@2|Bacteria	2|Bacteria	T	Band 7 protein	yqiK	-	-	ko:K07192	ko04910,map04910	-	-	-	ko00000,ko00001,ko03036,ko04131,ko04147	-	-	-	Band_7,Flot
TH2_k127_8002817_0	382464.ABSI01000012_gene2146	4.534e-174	569.0	COG1593@1|root,COG1593@2|Bacteria	2|Bacteria	G	mannitol 2-dehydrogenase activity	-	-	-	ko:K11690	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctM,DctQ
TH2_k127_8002817_3	395495.Lcho_3612	3.785e-102	346.0	COG1638@1|root,COG1638@2|Bacteria,1PMWE@1224|Proteobacteria,2VNJI@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
TH2_k127_8002817_4	335543.Sfum_2673	4.719e-84	289.0	COG5660@1|root,2Z7TM@2|Bacteria,1PMCV@1224|Proteobacteria,42Q81@68525|delta/epsilon subdivisions,2WIJ3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	TRAP transporter T-component	-	-	-	-	-	-	-	-	-	-	-	-	TAtT
TH2_k127_8002817_1	880073.Calab_0813	6.738e-153	514.0	COG1199@1|root,COG1199@2|Bacteria	2|Bacteria	L	ATP-dependent helicase activity	-	-	3.6.4.12	ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2
TH2_k127_8002817_5	1279009.ADICEAN_02097	1.198e-40	161.0	COG0823@1|root,COG1649@1|root,COG2931@1|root,COG3055@1|root,COG3210@1|root,COG4733@1|root,COG0823@2|Bacteria,COG1649@2|Bacteria,COG2931@2|Bacteria,COG3055@2|Bacteria,COG3210@2|Bacteria,COG4733@2|Bacteria,4NPRK@976|Bacteroidetes	976|Bacteroidetes	U	PFAM Uncharacterised BCR, COG1649	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8002817_6	1038869.AXAN01000016_gene1420	2.914e-28	121.0	2E5SP@1|root,330H2@2|Bacteria,1NDBY@1224|Proteobacteria,2VXDV@28216|Betaproteobacteria,1K76Z@119060|Burkholderiaceae	28216|Betaproteobacteria	S	YMGG-like Gly-zipper	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_YMGG
TH2_k127_8002817_7	1380391.JIAS01000012_gene4175	6.94e-24	102.0	COG4786@1|root,COG4786@2|Bacteria,1MZXB@1224|Proteobacteria,2TTM8@28211|Alphaproteobacteria,2JWNT@204441|Rhodospirillales	204441|Rhodospirillales	N	Protein of unknown function (DUF2950)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2950
TH2_k127_806677_4	1329516.JPST01000003_gene1120	1.1e-56	206.0	COG0181@1|root,COG0181@2|Bacteria,1TPFQ@1239|Firmicutes,4H9TV@91061|Bacilli,27B5B@186824|Thermoactinomycetaceae	91061|Bacilli	H	Porphobilinogen deaminase, dipyromethane cofactor binding domain	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
TH2_k127_806677_2	1396141.BATP01000057_gene2984	1.622e-81	296.0	COG0373@1|root,COG0373@2|Bacteria,46SMQ@74201|Verrucomicrobia,2IU0T@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	Glutamyl-tRNAGlu reductase, N-terminal domain	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,Shikimate_DH
TH2_k127_806677_5	497964.CfE428DRAFT_4314	1.167e-39	158.0	COG4137@1|root,COG4137@2|Bacteria,46T0T@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Cytochrome C assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
TH2_k127_806677_7	667014.Thein_0177	5.78e-37	145.0	COG1648@1|root,COG1648@2|Bacteria,2GH09@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	Sirohaem biosynthesis protein central	-	-	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_binding_7,Sirohm_synth_M
TH2_k127_806677_8	794903.OPIT5_30580	1.23e-26	120.0	COG1579@1|root,COG1579@2|Bacteria,46T10@74201|Verrucomicrobia,3K7Z2@414999|Opitutae	414999|Opitutae	S	C4-type zinc ribbon domain	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
TH2_k127_806677_3	1307759.JOMJ01000004_gene2677	3.683e-58	220.0	COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,42MBW@68525|delta/epsilon subdivisions,2WK2Z@28221|Deltaproteobacteria,2M972@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	TIGRFAM ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Rrf2,Virul_fac_BrkB
TH2_k127_806677_0	1403819.BATR01000112_gene3749	4.557e-177	563.0	COG1509@1|root,COG1509@2|Bacteria,46SVQ@74201|Verrucomicrobia,2ITNU@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Lysine-2,3-aminomutase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,LAM_C,Radical_SAM
TH2_k127_806677_10	656519.Halsa_0156	1.543e-18	97.0	COG0679@1|root,COG0679@2|Bacteria,1UY4N@1239|Firmicutes,24ACC@186801|Clostridia,3WANX@53433|Halanaerobiales	186801|Clostridia	S	Auxin Efflux Carrier	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
TH2_k127_806677_1	324602.Caur_3552	4.832e-101	349.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088,DUF362
TH2_k127_806677_6	1237149.C900_00059	4.148e-37	151.0	28NZH@1|root,2ZBWE@2|Bacteria,4NM7N@976|Bacteroidetes,47V8T@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_806677_9	1403819.BATR01000042_gene1236	1.118e-19	99.0	2EV5U@1|root,33NKM@2|Bacteria,46WDA@74201|Verrucomicrobia,2IUTJ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8137815_2	497964.CfE428DRAFT_1800	2.37e-69	250.0	COG1475@1|root,COG1475@2|Bacteria,46SQ8@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Belongs to the ParB family	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
TH2_k127_8137815_1	926550.CLDAP_34490	2.023e-103	348.0	COG1210@1|root,COG1210@2|Bacteria,2G6XV@200795|Chloroflexi	200795|Chloroflexi	M	PFAM Nucleotidyl transferase	-	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TH2_k127_8137815_0	926550.CLDAP_27180	0.0	1506.0	COG4284@1|root,COG4284@2|Bacteria	2|Bacteria	G	Utp--glucose-1-phosphate uridylyltransferase	-	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPGP
TH2_k127_8162153_1	314230.DSM3645_25337	3.913e-42	164.0	COG0811@1|root,COG0811@2|Bacteria,2IZ3U@203682|Planctomycetes	203682|Planctomycetes	U	MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
TH2_k127_8162153_3	706587.Desti_0722	5.085e-10	66.0	COG0848@1|root,COG0848@2|Bacteria,1NN40@1224|Proteobacteria,42USN@68525|delta/epsilon subdivisions,2X5N4@28221|Deltaproteobacteria	68525|delta/epsilon subdivisions	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
TH2_k127_8162153_2	762903.Pedsa_1064	6.77e-29	136.0	COG0823@1|root,COG2885@1|root,COG0823@2|Bacteria,COG2885@2|Bacteria,4NE6G@976|Bacteroidetes,1IPCG@117747|Sphingobacteriia	976|Bacteroidetes	MU	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,PD40,TPR_16,TPR_2,TPR_8
TH2_k127_8162153_0	756272.Plabr_2226	3.905e-73	280.0	COG1657@1|root,COG1657@2|Bacteria,2IYCT@203682|Planctomycetes	203682|Planctomycetes	I	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans
TH2_k127_8193631_7	118161.KB235922_gene1790	8.58e-31	138.0	COG1018@1|root,COG1716@1|root,COG1018@2|Bacteria,COG1716@2|Bacteria,1G49Z@1117|Cyanobacteria,3VIWR@52604|Pleurocapsales	1117|Cyanobacteria	CT	Oxidoreductase FAD-binding domain	-	-	-	ko:K21832	-	-	-	-	ko00000	-	-	-	FAD_binding_6,FHA,Fer2,NAD_binding_1
TH2_k127_8193631_12	583355.Caka_1222	3.265e-15	88.0	COG5523@1|root,COG5523@2|Bacteria,46ZK6@74201|Verrucomicrobia,3KA3R@414999|Opitutae	2|Bacteria	S	Domain of unknown function (DUF4339)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4339,DUF975
TH2_k127_8193631_11	880072.Desac_2421	2.454e-15	89.0	COG5523@1|root,COG5523@2|Bacteria,1RGXF@1224|Proteobacteria,42WIC@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF975
TH2_k127_8193631_6	398767.Glov_3582	1.424e-34	140.0	2ECUE@1|root,336RY@2|Bacteria,1P3V9@1224|Proteobacteria,431ZA@68525|delta/epsilon subdivisions,2WX45@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8193631_13	1403819.BATR01000055_gene1712	2.747e-09	69.0	2EG13@1|root,339T4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8193631_10	583355.Caka_1229	8.06e-21	95.0	2ES4R@1|root,33JPJ@2|Bacteria,46T9B@74201|Verrucomicrobia,3K9WE@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8193631_2	497964.CfE428DRAFT_2656	4.838e-108	370.0	2EQIM@1|root,2ZBQ8@2|Bacteria,46TFZ@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function (DUF4129)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129
TH2_k127_8193631_5	497964.CfE428DRAFT_2657	5.835e-67	244.0	COG5414@1|root,COG5414@2|Bacteria,46VD3@74201|Verrucomicrobia	74201|Verrucomicrobia	K	histone acetyltransferase binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8193631_0	497964.CfE428DRAFT_2658	1.782e-144	465.0	COG0714@1|root,COG0714@2|Bacteria,46S8X@74201|Verrucomicrobia	74201|Verrucomicrobia	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TH2_k127_8193631_4	497964.CfE428DRAFT_1467	8.614e-70	246.0	COG0131@1|root,COG0131@2|Bacteria,46SR2@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
TH2_k127_8193631_3	313628.LNTAR_16798	4.403e-93	318.0	COG0079@1|root,COG0079@2|Bacteria	2|Bacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iJN678.hisC	Aminotran_1_2
TH2_k127_8193631_1	313628.LNTAR_08241	2.422e-111	373.0	COG0141@1|root,COG0141@2|Bacteria	2|Bacteria	E	histidinol dehydrogenase activity	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23,1.1.1.308	ko:K00013,ko:K15509	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	iECUMN_1333.ECUMN_2362,iG2583_1286.G2583_2541,iUTI89_1310.UTI89_C2293,ic_1306.c2547	Histidinol_dh
TH2_k127_8193631_14	1150469.RSPPHO_02781	6.634e-09	59.0	COG2165@1|root,COG2165@2|Bacteria,1PJ5F@1224|Proteobacteria,2VC7I@28211|Alphaproteobacteria,2JY2W@204441|Rhodospirillales	204441|Rhodospirillales	NU	general secretion pathway protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8193631_9	1123070.KB899254_gene1219	2.688e-21	100.0	COG0703@1|root,COG0703@2|Bacteria,46T2U@74201|Verrucomicrobia,2IUGN@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
TH2_k127_8193631_8	1173028.ANKO01000190_gene422	1.166e-22	100.0	COG0128@1|root,COG0128@2|Bacteria,1G1F9@1117|Cyanobacteria,1H72W@1150|Oscillatoriales	1117|Cyanobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
TH2_k127_8219585_17	1519464.HY22_14065	6.415e-23	107.0	2DDRS@1|root,2ZJ0Y@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF4230)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4230
TH2_k127_8219585_0	497964.CfE428DRAFT_4579	9.521e-187	599.0	COG0018@1|root,COG0018@2|Bacteria,46SH6@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Arginyl tRNA synthetase N terminal dom	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
TH2_k127_8219585_5	1069080.KB913028_gene1858	1.949e-50	195.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,4H2BH@909932|Negativicutes	909932|Negativicutes	KLT	serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
TH2_k127_8219585_23	1156937.MFUM_970058	0.0001032	45.0	COG2151@1|root,COG2151@2|Bacteria,46SWX@74201|Verrucomicrobia,37GIM@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Pfam:DUF59	paaD	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
TH2_k127_8219585_24	525904.Tter_2724	0.0001677	48.0	COG3439@1|root,COG3439@2|Bacteria,2NPV1@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
TH2_k127_8219585_22	429009.Adeg_0631	6.251e-07	57.0	COG0589@1|root,COG0589@2|Bacteria,1VEJR@1239|Firmicutes,24QQ6@186801|Clostridia,42H8S@68295|Thermoanaerobacterales	186801|Clostridia	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TH2_k127_8219585_6	903818.KI912268_gene3047	7.298e-49	179.0	COG2193@1|root,COG2193@2|Bacteria	2|Bacteria	P	ferroxidase activity	bfr	GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
TH2_k127_8219585_13	1408473.JHXO01000012_gene289	1.214e-36	148.0	COG2044@1|root,COG2044@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07092	-	-	-	-	ko00000	-	-	-	DrsE,DrsE_2
TH2_k127_8219585_21	632335.Calkr_2514	3.061e-10	74.0	COG1520@1|root,COG1520@2|Bacteria,1VAI5@1239|Firmicutes,25F0B@186801|Clostridia	186801|Clostridia	S	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
TH2_k127_8219585_10	1150474.JQJI01000011_gene56	7.27e-41	174.0	COG1520@1|root,COG4733@1|root,COG4964@1|root,COG1520@2|Bacteria,COG4733@2|Bacteria,COG4964@2|Bacteria,2GCVR@200918|Thermotogae	200918|Thermotogae	F	PFAM PQQ enzyme repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
TH2_k127_8219585_7	497964.CfE428DRAFT_0259	5.305e-45	171.0	COG2151@1|root,COG2151@2|Bacteria,46SWX@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Pfam:DUF59	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
TH2_k127_8219585_19	1244869.H261_14445	9.19e-18	92.0	COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,2TTM2@28211|Alphaproteobacteria,2JSUG@204441|Rhodospirillales	204441|Rhodospirillales	O	COG1214 Inactive homolog of metal-dependent proteases	yeaZ	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
TH2_k127_8219585_8	518766.Rmar_2519	3.566e-42	158.0	COG0802@1|root,COG0802@2|Bacteria,4NS89@976|Bacteroidetes,1FJHQ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	yjeE	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
TH2_k127_8219585_4	497964.CfE428DRAFT_3691	7.982e-66	245.0	COG0611@1|root,COG0611@2|Bacteria,46SV7@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
TH2_k127_8219585_18	240016.ABIZ01000001_gene5112	8.073e-19	98.0	COG1266@1|root,COG1266@2|Bacteria,46T6D@74201|Verrucomicrobia,2IUVK@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
TH2_k127_8219585_20	338963.Pcar_2548	4.906e-14	84.0	2CG1Y@1|root,32WID@2|Bacteria,1N01A@1224|Proteobacteria,42UK0@68525|delta/epsilon subdivisions,2WQED@28221|Deltaproteobacteria,43SMQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1573)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1573,PapD-like
TH2_k127_8219585_16	525897.Dbac_0382	9.336e-24	106.0	COG0607@1|root,COG0607@2|Bacteria,1N256@1224|Proteobacteria,42TIJ@68525|delta/epsilon subdivisions,2WQHB@28221|Deltaproteobacteria,2MGI3@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM Rhodanese domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TH2_k127_8219585_14	945713.IALB_1774	9.217e-30	124.0	COG2259@1|root,COG2259@2|Bacteria	2|Bacteria	S	methylamine metabolic process	mauE	-	-	-	-	-	-	-	-	-	-	-	DoxX,MauE
TH2_k127_8219585_9	1183377.Py04_0762	8.516e-42	158.0	COG0251@1|root,arCOG01630@2157|Archaea,2XXUZ@28890|Euryarchaeota,244C0@183968|Thermococci	183968|Thermococci	J	Endoribonuclease L-PSP	-	GO:0003674,GO:0003824,GO:0016787,GO:0019239	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
TH2_k127_8219585_2	497964.CfE428DRAFT_2107	1.909e-146	475.0	COG0617@1|root,COG0617@2|Bacteria,46S8B@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Poly A polymerase head domain	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
TH2_k127_8219585_1	278957.ABEA03000106_gene1847	7.354e-147	480.0	COG2204@1|root,COG2204@2|Bacteria,46SDB@74201|Verrucomicrobia,3K7F3@414999|Opitutae	414999|Opitutae	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH2_k127_8219585_3	497964.CfE428DRAFT_0922	1.741e-112	378.0	COG2805@1|root,COG2805@2|Bacteria,46SJF@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	PFAM type II secretion system protein E	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
TH2_k127_8219585_12	234267.Acid_6001	5.587e-38	165.0	COG3055@1|root,COG4447@1|root,COG3055@2|Bacteria,COG4447@2|Bacteria,3Y5BB@57723|Acidobacteria	57723|Acidobacteria	N	Galactose oxidase, central domain	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4
TH2_k127_8219585_11	1131812.JQMS01000001_gene2726	4.228e-38	166.0	COG1470@1|root,COG2304@1|root,COG3209@1|root,COG3391@1|root,COG1470@2|Bacteria,COG2304@2|Bacteria,COG3209@2|Bacteria,COG3391@2|Bacteria,4PKBQ@976|Bacteroidetes,1IJ7S@117743|Flavobacteriia,2P0VG@237|Flavobacterium	976|Bacteroidetes	M	C-terminal domain of CHU protein family	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Calx-beta,DUF5011,HYR,SprB
TH2_k127_8229341_24	561229.Dd1591_3670	1.62e-08	59.0	COG1401@1|root,COG1401@2|Bacteria,1MYQM@1224|Proteobacteria,1RSU7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	GTPase subunit of restriction endonuclease	-	-	-	ko:K07452	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	AAA_5
TH2_k127_8229341_8	247490.KSU1_C0522	1.779e-99	336.0	COG1131@1|root,COG1131@2|Bacteria,2IX20@203682|Planctomycetes	203682|Planctomycetes	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TH2_k127_8229341_18	237368.SCABRO_02220	2.216e-41	162.0	COG1277@1|root,COG1277@2|Bacteria,2J0HW@203682|Planctomycetes	203682|Planctomycetes	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
TH2_k127_8229341_13	1156937.MFUM_810031	4.339e-72	262.0	COG3225@1|root,COG3225@2|Bacteria,46SRK@74201|Verrucomicrobia,37G90@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	N	ABC-type uncharacterized transport system	gldG	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
TH2_k127_8229341_19	452637.Oter_0090	3.891e-34	151.0	2DN50@1|root,32VJ4@2|Bacteria,46TKZ@74201|Verrucomicrobia,3K748@414999|Opitutae	414999|Opitutae	S	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
TH2_k127_8229341_1	497964.CfE428DRAFT_2621	2.394e-151	489.0	COG1030@1|root,COG1030@2|Bacteria,46TAS@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD,SDH_sah
TH2_k127_8229341_5	1121920.AUAU01000014_gene2800	2.785e-108	358.0	COG0330@1|root,COG0330@2|Bacteria,3Y33E@57723|Acidobacteria	57723|Acidobacteria	O	PFAM Band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
TH2_k127_8229341_0	926569.ANT_00890	1.034e-276	867.0	28I0T@1|root,2Z85H@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4914)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4914
TH2_k127_8229341_4	1521187.JPIM01000035_gene3407	2.411e-113	377.0	COG0026@1|root,COG0026@2|Bacteria,2G5PV@200795|Chloroflexi,375PJ@32061|Chloroflexia	32061|Chloroflexia	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	-	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
TH2_k127_8229341_14	324602.Caur_2313	5.379e-60	212.0	COG0041@1|root,COG0041@2|Bacteria,2G6JS@200795|Chloroflexi,375UD@32061|Chloroflexia	32061|Chloroflexia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
TH2_k127_8229341_15	469383.Cwoe_0748	2.515e-52	193.0	COG0288@1|root,COG0288@2|Bacteria,2GNJF@201174|Actinobacteria	201174|Actinobacteria	P	Reversible hydration of carbon dioxide	cynT	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
TH2_k127_8229341_20	665956.HMPREF1032_03678	1.29e-28	128.0	COG2264@1|root,COG2264@2|Bacteria,1TPKI@1239|Firmicutes,247VY@186801|Clostridia,3WGGT@541000|Ruminococcaceae	186801|Clostridia	J	Methylates ribosomal protein L11	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
TH2_k127_8229341_10	562970.Btus_2414	2.057e-89	300.0	COG0605@1|root,COG0605@2|Bacteria,1TPXT@1239|Firmicutes,4HA6U@91061|Bacilli,2781X@186823|Alicyclobacillaceae	91061|Bacilli	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodA	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
TH2_k127_8229341_21	1047013.AQSP01000071_gene1940	3.004e-24	108.0	COG4747@1|root,COG4747@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ACT
TH2_k127_8229341_7	926550.CLDAP_32170	8.384e-102	346.0	COG0613@1|root,COG0613@2|Bacteria	2|Bacteria	Q	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604,DUF5011,SLH
TH2_k127_8229341_2	1120942.AUBM01000010_gene1308	2.516e-146	479.0	COG1063@1|root,COG1063@2|Bacteria,2H3Y2@201174|Actinobacteria,4D42Y@85005|Actinomycetales	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	-	ko:K19956	ko00051,map00051	-	R03234	RC00089	ko00000,ko00001,ko01000	-	-	-	ADH_N
TH2_k127_8229341_23	658086.HMPREF0994_03274	1.555e-15	87.0	COG2207@1|root,COG2207@2|Bacteria,1V48H@1239|Firmicutes,248BW@186801|Clostridia,27KVS@186928|unclassified Lachnospiraceae	186801|Clostridia	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2,HTH_18
TH2_k127_8229341_9	1120950.KB892746_gene3503	3.265e-90	304.0	COG5285@1|root,COG5285@2|Bacteria	2|Bacteria	Q	dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
TH2_k127_8229341_3	1232453.BAIF02000008_gene3029	1.37e-132	441.0	COG0407@1|root,COG0407@2|Bacteria,1UY51@1239|Firmicutes,24DZF@186801|Clostridia	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
TH2_k127_8229341_12	632292.Calhy_1971	1.011e-73	258.0	COG1028@1|root,COG1028@2|Bacteria,1USCB@1239|Firmicutes,24FET@186801|Clostridia,42IA2@68295|Thermoanaerobacterales	186801|Clostridia	IQ	PFAM Short-chain dehydrogenase reductase SDR	srlD	-	1.1.1.140	ko:K00068	ko00051,map00051	-	R05607	RC00085	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
TH2_k127_8229341_11	452637.Oter_3319	1.024e-84	287.0	COG3347@1|root,COG3347@2|Bacteria,46VF0@74201|Verrucomicrobia	74201|Verrucomicrobia	IQ	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
TH2_k127_8229341_17	1499967.BAYZ01000040_gene2240	2.062e-41	165.0	COG4221@1|root,COG4221@2|Bacteria,2NPJV@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short
TH2_k127_8229341_6	632292.Calhy_0137	4.328e-103	350.0	COG5434@1|root,COG5434@2|Bacteria,1TQQW@1239|Firmicutes,24A0R@186801|Clostridia,42F7N@68295|Thermoanaerobacterales	186801|Clostridia	G	Belongs to the glycosyl hydrolase 28 family	-	-	3.2.1.67	ko:K01213	ko00040,ko01100,map00040,map01100	M00081	R01982,R07413	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_28,Pectate_lyase_3
TH2_k127_8229341_16	861299.J421_1407	2.438e-44	168.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TH2_k127_8229341_22	861299.J421_1409	3.452e-18	92.0	2EV6U@1|root,33NMK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8247702_4	1303518.CCALI_00744	6.865e-83	283.0	COG1136@1|root,COG1136@2|Bacteria	2|Bacteria	V	lipoprotein transporter activity	-	-	-	ko:K02003,ko:K02031,ko:K02032	ko02024,map02024	M00239,M00258	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.5	-	-	ABC_tran
TH2_k127_8247702_2	497965.Cyan7822_2990	5.636e-261	821.0	COG0493@1|root,COG0493@2|Bacteria,1G0SD@1117|Cyanobacteria,3KJF4@43988|Cyanothece	1117|Cyanobacteria	C	TIGRFAM glutamate synthase, NADH NADPH, small subunit	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	iJN678.gltD	Fer4_20,Pyr_redox_2
TH2_k127_8247702_0	452637.Oter_0894	0.0	2179.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,46U9T@74201|Verrucomicrobia,3K7GP@414999|Opitutae	414999|Opitutae	E	glutamate synthase	-	-	1.4.7.1	ko:K00284	ko00630,ko00910,ko01120,map00630,map00910,map01120	-	R00021,R10086	RC00006,RC00010	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
TH2_k127_8247702_3	886293.Sinac_4869	7.847e-91	308.0	COG0583@1|root,COG0583@2|Bacteria,2IYFV@203682|Planctomycetes	203682|Planctomycetes	K	COG0583 Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TH2_k127_8247702_5	452637.Oter_2652	4.637e-31	125.0	COG0316@1|root,COG0316@2|Bacteria,46VWZ@74201|Verrucomicrobia,3K8AD@414999|Opitutae	414999|Opitutae	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
TH2_k127_8247702_1	1396141.BATP01000005_gene5989	0.0	1028.0	COG0422@1|root,COG0422@2|Bacteria,46S5R@74201|Verrucomicrobia,2ITWP@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	ThiC-associated domain	-	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
TH2_k127_8290906_5	497964.CfE428DRAFT_6620	6.742e-67	231.0	COG2360@1|root,COG2360@2|Bacteria,46VHR@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
TH2_k127_8290906_1	1437425.CSEC_0671	1.688e-157	512.0	COG1070@1|root,COG1070@2|Bacteria	2|Bacteria	G	xylulokinase activity	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
TH2_k127_8290906_3	478741.JAFS01000002_gene821	2.992e-91	320.0	COG0635@1|root,COG0635@2|Bacteria,46STN@74201|Verrucomicrobia,37FV5@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
TH2_k127_8290906_11	768671.ThimaDRAFT_0905	5.866e-28	119.0	2E2ED@1|root,32XIY@2|Bacteria,1N2TC@1224|Proteobacteria,1SA49@1236|Gammaproteobacteria,1WZ4P@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8290906_17	1245469.S58_42560	3.245e-07	57.0	28PFN@1|root,2ZC6T@2|Bacteria,1RA18@1224|Proteobacteria,2U6F5@28211|Alphaproteobacteria,3K3XH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8290906_15	1040982.AXAL01000010_gene4140	2.56e-13	77.0	28PFN@1|root,2ZC6T@2|Bacteria,1RA18@1224|Proteobacteria,2U6F5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8290906_7	68570.DC74_2157	4.65e-45	181.0	COG1011@1|root,COG1011@2|Bacteria,2GN3E@201174|Actinobacteria	201174|Actinobacteria	S	hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
TH2_k127_8290906_6	497964.CfE428DRAFT_6695	3.458e-53	193.0	COG0233@1|root,COG0233@2|Bacteria,46V49@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
TH2_k127_8290906_2	247490.KSU1_C0880	5.831e-107	353.0	COG0005@1|root,COG0005@2|Bacteria,2IZAA@203682|Planctomycetes	203682|Planctomycetes	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	-	-	2.4.2.1,2.4.2.28	ko:K00772,ko:K03783	ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110	M00034	R01402,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
TH2_k127_8290906_10	1499684.CCNP01000018_gene1250	1.647e-31	132.0	COG2968@1|root,COG2968@2|Bacteria,1UFP4@1239|Firmicutes,24I3T@186801|Clostridia,36KBN@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
TH2_k127_8290906_19	402777.KB235903_gene1871	0.0003156	48.0	COG2378@1|root,COG2378@2|Bacteria,1G2ZJ@1117|Cyanobacteria,1HA8U@1150|Oscillatoriales	1117|Cyanobacteria	K	WYL domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
TH2_k127_8290906_8	1123229.AUBC01000001_gene1711	1.289e-36	155.0	COG1002@1|root,COG1002@2|Bacteria,1MWRH@1224|Proteobacteria,2TSWZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	COG1002 Type II restriction enzyme, methylase subunits	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
TH2_k127_8290906_4	479434.Sthe_3349	2.252e-90	311.0	COG1002@1|root,COG1002@2|Bacteria	2|Bacteria	V	DNA modification	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
TH2_k127_8290906_18	398767.Glov_3686	9.512e-06	55.0	COG1002@1|root,COG1002@2|Bacteria,1MWRH@1224|Proteobacteria,42Q0M@68525|delta/epsilon subdivisions,2WMGK@28221|Deltaproteobacteria,43USC@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	type II restriction enzyme, methylase	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
TH2_k127_8290906_12	1191523.MROS_1415	1.056e-24	106.0	COG0776@1|root,COG0776@2|Bacteria	2|Bacteria	L	regulation of translation	hup	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
TH2_k127_8290906_16	1415779.JOMH01000001_gene2432	1.015e-08	64.0	COG0848@1|root,COG0848@2|Bacteria,1RI4M@1224|Proteobacteria,1S7FH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
TH2_k127_8290906_9	187272.Mlg_1436	2.732e-33	138.0	COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,1RQWT@1236|Gammaproteobacteria,1WX5A@135613|Chromatiales	135613|Chromatiales	U	PFAM MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
TH2_k127_8290906_20	478741.JAFS01000001_gene1096	0.0006531	51.0	COG3064@1|root,COG3064@2|Bacteria,46VZ5@74201|Verrucomicrobia,37G07@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8290906_0	269799.Gmet_1669	4.379e-199	642.0	COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,42PWS@68525|delta/epsilon subdivisions,2WKI5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
TH2_k127_8290906_13	1121033.AUCF01000014_gene1300	1.06e-17	90.0	2E3CB@1|root,32YBM@2|Bacteria,1N6WD@1224|Proteobacteria,2UFAQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4154)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4154
TH2_k127_8317577_1	497964.CfE428DRAFT_0163	8.805e-84	286.0	COG0322@1|root,COG0322@2|Bacteria,46SAJ@74201|Verrucomicrobia	74201|Verrucomicrobia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
TH2_k127_8317577_11	452637.Oter_4402	0.000105	52.0	COG3678@1|root,COG3678@2|Bacteria,46WX9@74201|Verrucomicrobia	74201|Verrucomicrobia	NPTU	Heavy-metal resistance	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8317577_6	382464.ABSI01000011_gene2353	2.328e-31	139.0	COG1538@1|root,COG1538@2|Bacteria,46WHQ@74201|Verrucomicrobia,2IW13@203494|Verrucomicrobiae	203494|Verrucomicrobiae	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TH2_k127_8317577_2	903818.KI912269_gene524	2.561e-71	266.0	COG0845@1|root,COG0845@2|Bacteria,3Y49U@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07798	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1	-	-	HlyD_D23,YtkA
TH2_k127_8317577_0	246197.MXAN_0988	0.0	1113.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria,2YUB0@29|Myxococcales	28221|Deltaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	iAF987.Gmet_1547	ACR_tran
TH2_k127_8317577_7	478741.JAFS01000002_gene409	2.941e-28	121.0	2AG58@1|root,3169Z@2|Bacteria,46WMP@74201|Verrucomicrobia,37GPD@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8317577_5	497964.CfE428DRAFT_3795	2.841e-33	145.0	COG4726@1|root,COG4726@2|Bacteria,46T3V@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	Pilus assembly protein PilX	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8317577_4	452637.Oter_0650	1.48e-36	154.0	COG4726@1|root,COG4726@2|Bacteria,46YMK@74201|Verrucomicrobia,3K9UG@414999|Opitutae	414999|Opitutae	NU	Pilus assembly protein PilX	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8317577_3	497964.CfE428DRAFT_5735	5.677e-71	260.0	COG4796@1|root,COG4796@2|Bacteria,46STU@74201|Verrucomicrobia	74201|Verrucomicrobia	U	PFAM type II and III secretion system protein	-	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	Secretin
TH2_k127_8317577_9	631362.Thi970DRAFT_01004	1.679e-07	63.0	COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,1RN8S@1236|Gammaproteobacteria,1WXGR@135613|Chromatiales	135613|Chromatiales	NU	TIGRFAM type IV pilus assembly protein PilM	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
TH2_k127_8317577_12	1190603.AJYD01000081_gene241	0.0008796	48.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,1S3VS@1236|Gammaproteobacteria,1XWYF@135623|Vibrionales	135623|Vibrionales	U	general secretion pathway protein	epsG	GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
TH2_k127_8317577_8	497964.CfE428DRAFT_4965	2.034e-12	71.0	COG2165@1|root,COG2165@2|Bacteria,46T8M@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	general secretion pathway protein	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
TH2_k127_8346905_1	886293.Sinac_4963	3.243e-193	611.0	COG0297@1|root,COG0297@2|Bacteria	2|Bacteria	G	glycogen (starch) synthase activity	glgA	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901576	2.4.1.342	ko:K16148	ko00500,ko01100,map00500,map01100	-	R02421,R11530	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
TH2_k127_8346905_7	880072.Desac_2413	3.092e-118	389.0	COG1085@1|root,COG1085@2|Bacteria,1MU3E@1224|Proteobacteria,42MP4@68525|delta/epsilon subdivisions,2WKT8@28221|Deltaproteobacteria,2MR4U@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Domain of unknown function (DUF4921)	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4921,GalP_UDP_tr_C,GalP_UDP_transf
TH2_k127_8346905_2	497964.CfE428DRAFT_0917	2.901e-191	635.0	COG1449@1|root,COG1449@2|Bacteria,46TQI@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Glycosyl hydrolase family 57	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
TH2_k127_8346905_0	595536.ADVE02000001_gene3060	8.127e-216	702.0	COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,2TU4W@28211|Alphaproteobacteria,36Z5E@31993|Methylocystaceae	28211|Alphaproteobacteria	L	SNF2 family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
TH2_k127_8346905_15	452652.KSE_71810	0.0003259	51.0	COG1524@1|root,COG1524@2|Bacteria,2HQI2@201174|Actinobacteria,2M1M0@2063|Kitasatospora	201174|Actinobacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	PE,Phosphodiest
TH2_k127_8346905_4	1384056.N787_09610	1.704e-177	574.0	COG0471@1|root,COG3273@1|root,COG0471@2|Bacteria,COG3273@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1X4VE@135614|Xanthomonadales	135614|Xanthomonadales	P	Sodium:sulfate symporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
TH2_k127_8346905_9	273068.TTE1526	7.356e-107	361.0	COG1092@1|root,COG1092@2|Bacteria,1TRAJ@1239|Firmicutes,247TI@186801|Clostridia,42F3J@68295|Thermoanaerobacterales	186801|Clostridia	J	SMART PUA domain containing protein	rlmI	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,PUA
TH2_k127_8346905_6	756067.MicvaDRAFT_0415	2.127e-132	429.0	COG0714@1|root,COG0714@2|Bacteria,1G0WS@1117|Cyanobacteria,1H9JV@1150|Oscillatoriales	1117|Cyanobacteria	O	PFAM ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TH2_k127_8346905_11	452637.Oter_4153	2.402e-91	312.0	COG0263@1|root,COG0263@2|Bacteria,46SWM@74201|Verrucomicrobia,3K78E@414999|Opitutae	414999|Opitutae	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
TH2_k127_8346905_5	497964.CfE428DRAFT_1886	4.979e-153	494.0	COG0014@1|root,COG0014@2|Bacteria,46SGA@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TH2_k127_8346905_13	497964.CfE428DRAFT_2155	5.415e-76	267.0	COG1482@1|root,COG1482@2|Bacteria,46SVM@74201|Verrucomicrobia	74201|Verrucomicrobia	G	PFAM mannose-6-phosphate isomerase type I	manA	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	PMI_typeI
TH2_k127_8346905_3	497964.CfE428DRAFT_2154	3.261e-178	586.0	COG1674@1|root,COG1674@2|Bacteria,46SCV@74201|Verrucomicrobia	74201|Verrucomicrobia	D	PFAM cell divisionFtsK SpoIIIE	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
TH2_k127_8346905_14	497964.CfE428DRAFT_0050	2.743e-22	99.0	COG3063@1|root,COG3063@2|Bacteria,46T56@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	PPR,TPR_11,TPR_2,TPR_8
TH2_k127_8346905_10	756067.MicvaDRAFT_0416	4.04e-105	357.0	COG1721@1|root,COG1721@2|Bacteria,1G1ZM@1117|Cyanobacteria,1HA2D@1150|Oscillatoriales	1117|Cyanobacteria	S	protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
TH2_k127_8346905_8	1541065.JRFE01000011_gene4569	3.784e-113	394.0	COG1305@1|root,COG1305@2|Bacteria,1G1YY@1117|Cyanobacteria,3VKRN@52604|Pleurocapsales	1117|Cyanobacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
TH2_k127_8346905_12	1408473.JHXO01000011_gene3175	8.868e-80	277.0	COG0111@1|root,COG0111@2|Bacteria,4NGEB@976|Bacteroidetes,2FMMV@200643|Bacteroidia	976|Bacteroidetes	H	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate	pdxB	-	1.1.1.290	ko:K03473	ko00750,ko01100,map00750,map01100	M00124	R04210	RC00084	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C,DUF3410
TH2_k127_8348562_3	649638.Trad_2773	7.574e-36	140.0	COG2202@1|root,COG4585@1|root,COG2202@2|Bacteria,COG4585@2|Bacteria,1WMUT@1297|Deinococcus-Thermus	2|Bacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	mcpA	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HATPase_c,HisKA_3,MCPsignal,PAS_3,PAS_4,PAS_9
TH2_k127_8348562_0	1123253.AUBD01000001_gene1589	1.395e-210	665.0	COG3046@1|root,COG3046@2|Bacteria,1MUHX@1224|Proteobacteria,1RNUM@1236|Gammaproteobacteria,1X2YB@135614|Xanthomonadales	135614|Xanthomonadales	S	Deoxyribodipyrimidine photo-lyase-related protein	-	-	-	ko:K06876	-	-	-	-	ko00000	-	-	-	DPRP
TH2_k127_8348562_2	756272.Plabr_3042	2.785e-51	186.0	COG3476@1|root,COG3476@2|Bacteria,2J03F@203682|Planctomycetes	203682|Planctomycetes	T	PFAM TspO MBR family	-	-	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
TH2_k127_8348562_1	240016.ABIZ01000001_gene1742	1.396e-134	443.0	COG1861@1|root,COG1861@2|Bacteria,46UVT@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
TH2_k127_8361394_2	1210884.HG799466_gene12905	1.716e-103	348.0	COG1520@1|root,COG1520@2|Bacteria,2IX2Z@203682|Planctomycetes	203682|Planctomycetes	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
TH2_k127_8361394_8	1131269.AQVV01000044_gene1784	2.773e-06	61.0	2FEYA@1|root,346X0@2|Bacteria	1131269.AQVV01000044_gene1784|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8361394_5	929713.NIASO_11325	2.361e-31	143.0	COG3533@1|root,COG3533@2|Bacteria,4NFW3@976|Bacteroidetes	976|Bacteroidetes	G	glycosyl hydrolase of	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Glyco_hydro_127
TH2_k127_8361394_6	1352941.M877_12005	3.407e-17	96.0	COG1082@1|root,COG1470@1|root,COG1082@2|Bacteria,COG1470@2|Bacteria,2GKFD@201174|Actinobacteria	201174|Actinobacteria	G	Glycoside hydrolase 97	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	GH97_C,GH97_N,Glyco_hydro_97,NPCBM,NPCBM_assoc,RicinB_lectin_2
TH2_k127_8361394_0	1280390.CBQR020000092_gene1955	1.628e-177	579.0	COG1874@1|root,COG1874@2|Bacteria,1TQN6@1239|Firmicutes,4HARI@91061|Bacilli,26SRJ@186822|Paenibacillaceae	91061|Bacilli	G	beta-galactosidase	lacA	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_42,Glyco_hydro_42C,Glyco_hydro_42M
TH2_k127_8361394_1	761193.Runsl_0088	2.085e-127	422.0	COG3669@1|root,COG4409@1|root,COG4692@1|root,COG3669@2|Bacteria,COG4409@2|Bacteria,COG4692@2|Bacteria,4NEDX@976|Bacteroidetes,47JNA@768503|Cytophagia	976|Bacteroidetes	G	Coagulation factor 5 8 type domain protein	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,CHB_HEX_C_1,F5_F8_type_C,Fn3_assoc
TH2_k127_8361394_9	1123508.JH636440_gene2309	1.538e-05	59.0	COG1520@1|root,COG1520@2|Bacteria,2IWVJ@203682|Planctomycetes	203682|Planctomycetes	S	WD40-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
TH2_k127_8361394_4	1267535.KB906767_gene241	4.298e-51	203.0	COG3345@1|root,COG3345@2|Bacteria,3Y3UB@57723|Acidobacteria,2JKQN@204432|Acidobacteriia	204432|Acidobacteriia	G	PFAM Glycoside hydrolase, clan GH-D	-	-	-	-	-	-	-	-	-	-	-	-	Melibiase
TH2_k127_8361394_7	344747.PM8797T_23946	3.559e-08	66.0	COG1520@1|root,COG1520@2|Bacteria,2IXKN@203682|Planctomycetes	203682|Planctomycetes	S	COG1520 FOG WD40-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
TH2_k127_8361394_3	101510.RHA1_ro01609	1.387e-90	303.0	COG3335@1|root,COG3335@2|Bacteria,2GJQI@201174|Actinobacteria,4FX98@85025|Nocardiaceae	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29
TH2_k127_8379668_3	1463934.JOCF01000069_gene5105	0.0006981	51.0	COG1555@1|root,COG1555@2|Bacteria,2IQDC@201174|Actinobacteria	201174|Actinobacteria	L	Competence protein ComEA	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
TH2_k127_8379668_0	497964.CfE428DRAFT_1215	1.552e-76	262.0	COG1100@1|root,COG1100@2|Bacteria,46VDZ@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Ras family	-	-	-	-	-	-	-	-	-	-	-	-	Arf
TH2_k127_8379668_2	1379698.RBG1_1C00001G1744	1.715e-15	83.0	COG2018@1|root,COG2018@2|Bacteria,2NQXH@2323|unclassified Bacteria	2|Bacteria	S	Roadblock/LC7 domain	mglB	-	-	-	-	-	-	-	-	-	-	-	Robl_LC7
TH2_k127_8379668_1	497964.CfE428DRAFT_0169	4.271e-41	160.0	COG0220@1|root,COG0220@2|Bacteria,46T5A@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	-	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
TH2_k127_8385130_0	1519464.HY22_01095	1.449e-203	642.0	COG0538@1|root,COG0538@2|Bacteria	2|Bacteria	C	isocitrate dehydrogenase activity	icd	GO:0003674,GO:0003824,GO:0003862,GO:0004448,GO:0004450,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006520,GO:0006551,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022900,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	e_coli_core.b1136,iAF1260.b1136,iECDH1ME8569_1439.ECDH1ME8569_1071,iEcDH1_1363.EcDH1_2511,iJN746.PP_4011,iJO1366.b1136,iJR904.b1136,iY75_1357.Y75_RS05930,iYL1228.KPN_01144	Iso_dh
TH2_k127_8385130_5	665571.STHERM_c10140	5.23e-55	198.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	yvcI	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
TH2_k127_8385130_3	1094508.Tsac_0819	8.573e-74	258.0	COG1694@1|root,COG3956@2|Bacteria,1TPK1@1239|Firmicutes,247XM@186801|Clostridia,42FE4@68295|Thermoanaerobacterales	186801|Clostridia	S	TIGRFAM MazG family protein	mazG	-	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG,TP_methylase
TH2_k127_8385130_1	452637.Oter_2737	4.194e-100	338.0	COG0787@1|root,COG0787@2|Bacteria,46UBN@74201|Verrucomicrobia,3K796@414999|Opitutae	414999|Opitutae	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	-	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
TH2_k127_8385130_2	1396141.BATP01000032_gene4314	8.384e-90	306.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TH2_k127_8385130_4	335543.Sfum_2864	9.249e-74	255.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,42QXM@68525|delta/epsilon subdivisions,2WMZI@28221|Deltaproteobacteria,2MRM3@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
TH2_k127_8416767_1	335543.Sfum_0251	2.821e-12	81.0	COG0577@1|root,COG2234@1|root,COG0577@2|Bacteria,COG2234@2|Bacteria,1MVYE@1224|Proteobacteria,42PKN@68525|delta/epsilon subdivisions,2WIWP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,PA,Peptidase_M28
TH2_k127_8416767_0	1303518.CCALI_01801	1.107e-13	81.0	28HQ2@1|root,2Z7XV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8455228_7	6087.XP_002158130.1	1.143e-17	85.0	2ERDI@1|root,2SU79@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8455228_3	1122138.AQUZ01000030_gene4716	2.699e-62	225.0	COG2207@1|root,COG2207@2|Bacteria,2IHDB@201174|Actinobacteria	201174|Actinobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TH2_k127_8455228_5	1380394.JADL01000009_gene3123	1.404e-44	173.0	COG5285@1|root,COG5285@2|Bacteria,1RC3C@1224|Proteobacteria	1224|Proteobacteria	Q	Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin	-	-	1.14.11.18	ko:K00477	ko04146,map04146	-	-	-	ko00000,ko00001,ko01000	-	-	-	PhyH
TH2_k127_8455228_4	525904.Tter_1945	1.063e-54	202.0	COG2207@1|root,COG2207@2|Bacteria,2NS0W@2323|unclassified Bacteria	2|Bacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K21826	-	-	-	-	ko00000,ko03000	-	-	-	AraC_binding,HTH_18,HTH_AraC
TH2_k127_8455228_1	382464.ABSI01000009_gene3973	3.062e-137	456.0	COG0685@1|root,COG0685@2|Bacteria,46TD1@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Methylene-tetrahydrofolate reductase C terminal	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,MTHFR_C
TH2_k127_8455228_6	452637.Oter_4334	1.63e-30	133.0	COG1410@1|root,COG1410@2|Bacteria,46UFH@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Pterin binding enzyme	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
TH2_k127_8455228_0	1380391.JIAS01000011_gene5152	2.298e-246	771.0	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,2TRMM@28211|Alphaproteobacteria,2JQ9A@204441|Rhodospirillales	204441|Rhodospirillales	F	formate-tetrahydrofolate ligase activity	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
TH2_k127_8455228_2	439235.Dalk_3021	1.162e-79	274.0	COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,42RRD@68525|delta/epsilon subdivisions,2WYUN@28221|Deltaproteobacteria,2MNA9@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8468550_2	1227739.Hsw_4060	1.393e-148	481.0	COG0659@1|root,COG0659@2|Bacteria	2|Bacteria	P	secondary active sulfate transmembrane transporter activity	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	MFS_MOT1
TH2_k127_8468550_1	1210884.HG799463_gene9317	2.346e-151	507.0	COG4191@1|root,COG4191@2|Bacteria,2IWUM@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TH2_k127_8468550_3	1403819.BATR01000092_gene2820	6.794e-29	123.0	2E3CB@1|root,32YBM@2|Bacteria,46W9H@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function (DUF4154)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4154
TH2_k127_8468550_0	269799.Gmet_1669	1.052e-214	687.0	COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,42PWS@68525|delta/epsilon subdivisions,2WKI5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
TH2_k127_8474086_0	497964.CfE428DRAFT_0775	2.817e-15	80.0	COG1721@1|root,COG1721@2|Bacteria	2|Bacteria	E	protein (some members contain a von Willebrand factor type A (vWA) domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
TH2_k127_8496354_3	1238182.C882_2396	3.737e-56	206.0	COG1028@1|root,COG1028@2|Bacteria,1MVQW@1224|Proteobacteria,2TUA2@28211|Alphaproteobacteria,2JQ5Y@204441|Rhodospirillales	204441|Rhodospirillales	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TH2_k127_8496354_1	639030.JHVA01000001_gene115	9.089e-81	284.0	COG0006@1|root,COG0006@2|Bacteria,3Y3IN@57723|Acidobacteria,2JI8R@204432|Acidobacteriia	2|Bacteria	E	Creatinase/Prolidase N-terminal domain	pepQ	-	3.5.3.3	ko:K08688	ko00260,ko00330,ko01100,map00260,map00330,map01100	-	R01566	RC00548,RC00549	ko00000,ko00001,ko01000	-	-	-	Creatinase_N,Peptidase_M24
TH2_k127_8496354_2	485913.Krac_2662	6.294e-78	270.0	COG1028@1|root,COG1028@2|Bacteria,2G5R0@200795|Chloroflexi	200795|Chloroflexi	IQ	Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
TH2_k127_8496354_5	883126.HMPREF9710_03339	0.0003697	53.0	COG1501@1|root,COG1501@2|Bacteria,1MVYP@1224|Proteobacteria,2W144@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Melibiase	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Melibiase
TH2_k127_8496354_0	1123242.JH636435_gene1113	1.821e-111	376.0	COG3875@1|root,COG3875@2|Bacteria,2IY1E@203682|Planctomycetes	203682|Planctomycetes	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
TH2_k127_8496354_4	1238450.VIBNISOn1_280048	2.299e-49	184.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,1RMNY@1236|Gammaproteobacteria,1XUZV@135623|Vibrionales	135623|Vibrionales	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
TH2_k127_8531893_7	671143.DAMO_3157	6.446e-05	52.0	28VYX@1|root,2ZI05@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8531893_1	497964.CfE428DRAFT_5946	6.951e-62	221.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TH2_k127_8531893_4	404380.Gbem_1143	8.074e-12	72.0	COG3678@1|root,COG3678@2|Bacteria	2|Bacteria	NPTU	ATP-independent chaperone mediated protein folding	-	-	-	ko:K06006	-	-	-	-	ko00000,ko03110	-	-	-	LTXXQ
TH2_k127_8531893_6	1245469.S58_69200	1.994e-06	61.0	2BTVT@1|root,32P3P@2|Bacteria,1NYS3@1224|Proteobacteria,2UT4H@28211|Alphaproteobacteria,3K4G5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8531893_2	1541065.JRFE01000026_gene2248	3.301e-50	190.0	COG0589@1|root,COG0589@2|Bacteria,1G0EZ@1117|Cyanobacteria,3VIDN@52604|Pleurocapsales	1117|Cyanobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TH2_k127_8531893_0	589865.DaAHT2_0221	7.891e-85	294.0	COG2172@1|root,COG2208@1|root,COG5002@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,COG5002@2|Bacteria,1PGCN@1224|Proteobacteria,42ZJ2@68525|delta/epsilon subdivisions,2WUYN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM Stage II sporulation E family protein	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
TH2_k127_8531893_5	497964.CfE428DRAFT_3681	3.183e-08	56.0	COG5421@1|root,COG5421@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2
TH2_k127_8537904_2	378806.STAUR_2791	5.259e-83	285.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,42PDR@68525|delta/epsilon subdivisions,2WJ60@28221|Deltaproteobacteria,2YURG@29|Myxococcales	28221|Deltaproteobacteria	L	A G-specific	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
TH2_k127_8537904_1	1379698.RBG1_1C00001G0015	1.451e-95	332.0	COG0840@1|root,COG4191@1|root,COG0840@2|Bacteria,COG4191@2|Bacteria,2NPGF@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.4.1.12,2.7.13.3,3.1.3.3	ko:K00694,ko:K03406,ko:K07315,ko:K14986	ko00500,ko01100,ko02020,ko02026,ko02030,map00500,map01100,map02020,map02026,map02030	M00524	R02889	RC00005	ko00000,ko00001,ko00002,ko01000,ko01001,ko01003,ko02000,ko02022,ko02035,ko03021	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	Cellulose_synt,HATPase_c,HisKA,NIT,PAS,PAS_4,PAS_9
TH2_k127_8537904_0	596324.TREVI0001_1210	9.492e-117	390.0	COG2204@1|root,COG2204@2|Bacteria,2J5NY@203691|Spirochaetes	203691|Spirochaetes	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	rrp-2	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TH2_k127_8537904_4	933262.AXAM01000078_gene1614	1.29e-33	148.0	COG1403@1|root,COG1403@2|Bacteria,1RGZQ@1224|Proteobacteria,42REM@68525|delta/epsilon subdivisions,2WNMG@28221|Deltaproteobacteria,2MJT7@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH
TH2_k127_8537904_3	497964.CfE428DRAFT_6227	9.883e-80	273.0	COG0676@1|root,COG0676@2|Bacteria,46VKE@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Aldose 1-epimerase	-	-	5.1.3.15	ko:K01792	ko00010,ko01100,ko01110,ko01120,ko01130,map00010,map01100,map01110,map01120,map01130	-	R02739	RC00563	ko00000,ko00001,ko01000	-	-	-	Aldose_epim
TH2_k127_8537904_7	29495.EA26_10740	0.0005346	44.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,1RMW9@1236|Gammaproteobacteria,1XVP1@135623|Vibrionales	135623|Vibrionales	G	Glycosyl hydrolase 36 superfamily, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_36,Glyco_transf_36
TH2_k127_8537904_5	555088.DealDRAFT_0194	2.293e-19	91.0	COG3668@1|root,COG3668@2|Bacteria,1VHZU@1239|Firmicutes	1239|Firmicutes	S	PFAM plasmid	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
TH2_k127_8551135_0	497964.CfE428DRAFT_1386	2.295e-114	377.0	COG0525@1|root,COG0525@2|Bacteria,46SGP@74201|Verrucomicrobia	74201|Verrucomicrobia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
TH2_k127_8551135_2	382464.ABSI01000010_gene3771	3.327e-18	90.0	2FBS3@1|root,343WW@2|Bacteria,46X6J@74201|Verrucomicrobia,2IUQ7@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8551135_1	1229487.AMYW01000076_gene2610	2.477e-40	164.0	COG3391@1|root,COG3391@2|Bacteria,4PMIF@976|Bacteroidetes,1IKM0@117743|Flavobacteriia,2P0WA@237|Flavobacterium	976|Bacteroidetes	N	HYR domain	-	-	-	-	-	-	-	-	-	-	-	-	HYR,Laminin_G_3
TH2_k127_8556074_0	497964.CfE428DRAFT_2502	8.362e-195	623.0	COG0513@1|root,COG0513@2|Bacteria,46U0S@74201|Verrucomicrobia	74201|Verrucomicrobia	L	DEAD DEAH box helicase domain protein	-	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
TH2_k127_8556074_1	1121904.ARBP01000004_gene955	6.447e-62	226.0	COG1073@1|root,COG1073@2|Bacteria,4NGG4@976|Bacteroidetes,47PZ3@768503|Cytophagia	976|Bacteroidetes	S	Serine aminopeptidase, S33	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	DLH,Hydrolase_4
TH2_k127_8556074_2	933262.AXAM01000034_gene1578	2.268e-11	68.0	28J8Y@1|root,2Z943@2|Bacteria,1REXC@1224|Proteobacteria,43DCS@68525|delta/epsilon subdivisions,2X8IT@28221|Deltaproteobacteria,2MK0X@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4338)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4338
TH2_k127_8618970_7	886293.Sinac_4694	3.08e-26	112.0	COG1657@1|root,COG1657@2|Bacteria,2IYCT@203682|Planctomycetes	203682|Planctomycetes	I	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans
TH2_k127_8618970_0	497964.CfE428DRAFT_2506	8.23e-245	771.0	COG0065@1|root,COG0065@2|Bacteria,46SUM@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
TH2_k127_8618970_3	1123070.KB899254_gene1231	8.491e-63	224.0	COG0571@1|root,COG0571@2|Bacteria,46T3X@74201|Verrucomicrobia,2IU7S@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
TH2_k127_8618970_2	1397528.Q671_02380	2.753e-78	267.0	COG4106@1|root,COG4106@2|Bacteria,1QUFH@1224|Proteobacteria,1T1X5@1236|Gammaproteobacteria,1XJS5@135619|Oceanospirillales	135619|Oceanospirillales	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
TH2_k127_8618970_6	1173027.Mic7113_4625	2.671e-42	161.0	COG1225@1|root,COG1225@2|Bacteria,1G55Y@1117|Cyanobacteria,1HB1H@1150|Oscillatoriales	1117|Cyanobacteria	O	PFAM AhpC TSA family	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
TH2_k127_8618970_1	481448.Minf_1980	2.186e-200	641.0	COG0119@1|root,COG0119@2|Bacteria,46S6Z@74201|Verrucomicrobia,37G7K@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	E	LeuA allosteric (dimerisation) domain	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
TH2_k127_8618970_5	518766.Rmar_2227	4.462e-49	182.0	COG2197@1|root,COG2197@2|Bacteria,4NP2G@976|Bacteroidetes,1FIR1@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TH2_k127_8618970_4	1123274.KB899415_gene2439	3.538e-52	196.0	COG0784@1|root,COG4585@1|root,COG0784@2|Bacteria,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388,HAMP,HATPase_c,HisKA_3,MASE1,PAS,PAS_3,PAS_4,Response_reg,dCache_2
TH2_k127_8633357_1	1502770.JQMG01000001_gene1479	2.211e-77	260.0	COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,2VHAK@28216|Betaproteobacteria,2KKWD@206350|Nitrosomonadales	206350|Nitrosomonadales	O	Carbamoyltransferase C-terminus	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
TH2_k127_8633357_3	1499967.BAYZ01000013_gene6453	1.397e-45	175.0	2CC7H@1|root,32RJ0@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8633357_2	383372.Rcas_3579	1.003e-64	239.0	COG1032@1|root,COG1032@2|Bacteria,2G86N@200795|Chloroflexi,37640@32061|Chloroflexia	32061|Chloroflexia	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TH2_k127_8633357_0	1121423.JONT01000002_gene2185	2.805e-148	479.0	COG0535@1|root,COG0535@2|Bacteria,1TR85@1239|Firmicutes,249NQ@186801|Clostridia,2600M@186807|Peptococcaceae	186801|Clostridia	C	PFAM Radical SAM	-	-	-	ko:K22226	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
TH2_k127_8633357_4	1210884.HG799466_gene12649	3.744e-44	163.0	COG1131@1|root,COG1131@2|Bacteria,2IY1H@203682|Planctomycetes	203682|Planctomycetes	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TH2_k127_8633357_5	886293.Sinac_3784	0.0001479	46.0	COG1131@1|root,COG1131@2|Bacteria,2IY1H@203682|Planctomycetes	203682|Planctomycetes	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TH2_k127_86425_6	247490.KSU1_D0176	4.885e-11	65.0	COG1943@1|root,COG1943@2|Bacteria,2IYXS@203682|Planctomycetes	203682|Planctomycetes	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
TH2_k127_86425_1	118168.MC7420_7427	2.036e-130	432.0	COG1012@1|root,COG1012@2|Bacteria,1G1BD@1117|Cyanobacteria,1H7AN@1150|Oscillatoriales	1117|Cyanobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.79,1.2.1.8	ko:K00128,ko:K00130,ko:K00135	ko00010,ko00053,ko00071,ko00250,ko00260,ko00280,ko00310,ko00330,ko00340,ko00350,ko00380,ko00410,ko00561,ko00620,ko00625,ko00650,ko00760,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00250,map00260,map00280,map00310,map00330,map00340,map00350,map00380,map00410,map00561,map00620,map00625,map00650,map00760,map00903,map00981,map01100,map01110,map01120,map01130	M00027,M00135,M00555	R00264,R00631,R00710,R00713,R00714,R00904,R01752,R01986,R02401,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TH2_k127_86425_0	1396418.BATQ01000116_gene4615	8.587e-197	636.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,46U7Q@74201|Verrucomicrobia,2ITXJ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	NAD synthase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase,NAD_synthase
TH2_k127_86425_7	756272.Plabr_0657	6.117e-07	58.0	COG3809@1|root,COG3809@2|Bacteria,2J0N6@203682|Planctomycetes	203682|Planctomycetes	S	Transcription factor zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-TFIIB
TH2_k127_86425_2	1132509.C447_11290	5.242e-102	354.0	COG3250@1|root,arCOG07337@2157|Archaea	2157|Archaea	G	COG3250 Beta-galactosidase beta-glucuronidase	-	-	3.2.1.31	ko:K01195	ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142	M00014,M00076,M00077,M00078,M00129	R01478,R04979,R07818,R08127,R08260,R10830	RC00055,RC00171,RC00529,RC00530,RC00714,RC01251	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
TH2_k127_86425_4	452637.Oter_2644	2.069e-47	179.0	COG0564@1|root,COG0564@2|Bacteria,46V2B@74201|Verrucomicrobia,3K828@414999|Opitutae	414999|Opitutae	J	Pseudouridine synthase	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
TH2_k127_86425_5	1394178.AWOO02000091_gene1049	2.334e-16	92.0	COG2270@1|root,COG2270@2|Bacteria,2GK5A@201174|Actinobacteria,4EQZ9@85012|Streptosporangiales	201174|Actinobacteria	S	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TH2_k127_86425_3	483219.LILAB_17800	1.598e-52	197.0	COG1716@1|root,COG1716@2|Bacteria,1RAA4@1224|Proteobacteria,431UR@68525|delta/epsilon subdivisions,2WWZQ@28221|Deltaproteobacteria,2YU65@29|Myxococcales	28221|Deltaproteobacteria	T	FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388,FHA,Yop-YscD_cpl
TH2_k127_86425_8	886377.Murru_0509	0.0003212	53.0	COG0457@1|root,COG1729@1|root,COG2956@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,COG2956@2|Bacteria,4NE4W@976|Bacteroidetes,1HX2D@117743|Flavobacteriia	976|Bacteroidetes	K	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_21,TPR_6,TPR_8
TH2_k127_8746104_1	794903.OPIT5_27210	1.417e-41	154.0	COG1158@1|root,COG1158@2|Bacteria,46S5Y@74201|Verrucomicrobia,3K7JV@414999|Opitutae	414999|Opitutae	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	-	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_RNA_bind
TH2_k127_8746104_0	497964.CfE428DRAFT_1614	2.75e-43	174.0	COG1197@1|root,COG1197@2|Bacteria,46S6Y@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
TH2_k127_8794205_7	497964.CfE428DRAFT_1210	5.073e-48	185.0	2E533@1|root,32ZW9@2|Bacteria,46SZX@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8794205_2	794903.OPIT5_26170	9.047e-91	314.0	COG1333@1|root,COG1333@2|Bacteria,46SUY@74201|Verrucomicrobia,3K75U@414999|Opitutae	414999|Opitutae	O	ResB-like family	-	-	-	-	-	-	-	-	-	-	-	-	ResB
TH2_k127_8794205_0	452637.Oter_2821	4.979e-165	542.0	COG0755@1|root,COG0755@2|Bacteria,46SIH@74201|Verrucomicrobia,3K7UF@414999|Opitutae	414999|Opitutae	O	PFAM cytochrome c assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
TH2_k127_8794205_6	497964.CfE428DRAFT_6518	2.926e-62	221.0	COG0242@1|root,COG0242@2|Bacteria,46SYF@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
TH2_k127_8794205_1	452637.Oter_2447	6.199e-131	431.0	COG1704@1|root,COG1704@2|Bacteria	2|Bacteria	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	GIDE,LemA
TH2_k127_8794205_9	1122951.ATUE01000008_gene74	3.941e-33	133.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,3NIQS@468|Moraxellaceae	1236|Gammaproteobacteria	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	hofB	-	-	ko:K02454,ko:K02504,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
TH2_k127_8794205_11	644966.Tmar_0414	7.472e-24	110.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia,3WDGI@538999|Clostridiales incertae sedis	186801|Clostridia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TH2_k127_8794205_10	945713.IALB_1975	1.165e-30	130.0	COG1215@1|root,COG3222@1|root,COG1215@2|Bacteria,COG3222@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2064)	-	-	3.4.14.13	ko:K09931,ko:K20742	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DUF2064,Glycos_transf_2
TH2_k127_8794205_8	452637.Oter_2376	4.017e-42	162.0	COG1443@1|root,COG1443@2|Bacteria,46T1S@74201|Verrucomicrobia,3K84X@414999|Opitutae	414999|Opitutae	I	NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TH2_k127_8794205_5	582515.KR51_00008970	4.146e-70	253.0	COG1565@1|root,COG1565@2|Bacteria,1G16Z@1117|Cyanobacteria	1117|Cyanobacteria	S	acr, cog1565	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
TH2_k127_8794205_3	478741.JAFS01000002_gene953	4.039e-71	250.0	COG1387@1|root,COG1387@2|Bacteria,46SMB@74201|Verrucomicrobia,37GD2@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	E	PHP domain	-	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP
TH2_k127_8794205_4	471223.GWCH70_1069	8.595e-71	246.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,4H9RW@91061|Bacilli,1WE4J@129337|Geobacillus	91061|Bacilli	G	Ribulose-phosphate 3 epimerase family	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
TH2_k127_8794205_12	767817.Desgi_4347	2.314e-18	90.0	COG1109@1|root,COG1109@2|Bacteria,1TP2N@1239|Firmicutes,2481Y@186801|Clostridia,260T2@186807|Peptococcaceae	186801|Clostridia	G	alpha beta alpha domain I	pgm	-	-	-	-	-	-	-	-	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TH2_k127_8802785_0	497964.CfE428DRAFT_0348	2.826e-231	751.0	COG0612@1|root,COG0612@2|Bacteria,46S9I@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM peptidase M16 domain protein	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
TH2_k127_8802785_1	452637.Oter_2367	3.523e-40	156.0	2E5IJ@1|root,3309Y@2|Bacteria,46SYV@74201|Verrucomicrobia,3K87A@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_8802785_3	1232437.KL661988_gene29	1.745e-05	50.0	COG1699@1|root,COG1699@2|Bacteria,1N9E7@1224|Proteobacteria,42V88@68525|delta/epsilon subdivisions,2WR7H@28221|Deltaproteobacteria,2MM39@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum	fliW	-	-	ko:K13626	-	-	-	-	ko00000,ko02035	-	-	-	FliW
TH2_k127_8825168_0	497964.CfE428DRAFT_2604	7.702e-109	363.0	COG0489@1|root,COG0489@2|Bacteria,46SAV@74201|Verrucomicrobia	74201|Verrucomicrobia	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
TH2_k127_8825168_1	886293.Sinac_7525	3.611e-52	191.0	COG1721@1|root,COG1721@2|Bacteria,2IYDH@203682|Planctomycetes	203682|Planctomycetes	S	protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
TH2_k127_8880584_1	1408473.JHXO01000009_gene3449	4.001e-06	54.0	COG1301@1|root,COG1301@2|Bacteria,4NDUU@976|Bacteroidetes,2G2YY@200643|Bacteroidia	976|Bacteroidetes	C	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	gltP	-	-	ko:K11102,ko:K11103	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.23.1.1,2.A.23.1.2,2.A.23.1.3,2.A.23.1.6,2.A.23.1.7	-	-	SDF
TH2_k127_8880584_0	1191523.MROS_1576	1.223e-34	143.0	COG3459@1|root,COG3459@2|Bacteria	2|Bacteria	G	carbohydrate binding	-	-	2.4.1.20	ko:K00702	ko00500,ko01100,map00500,map01100	-	R00952	RC00049	ko00000,ko00001,ko01000	-	GT36	-	Glyco_hydro_36,Glyco_transf_36
TH2_k127_8900183_0	1170562.Cal6303_0980	1.486e-170	546.0	COG1222@1|root,COG1222@2|Bacteria,1G1TR@1117|Cyanobacteria,1HM7E@1161|Nostocales	1117|Cyanobacteria	O	Holliday junction DNA helicase ruvB N-terminus	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA
TH2_k127_90846_1	439235.Dalk_0563	4.613e-114	373.0	COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,42MRS@68525|delta/epsilon subdivisions,2WJW8@28221|Deltaproteobacteria,2MIRN@213118|Desulfobacterales	28221|Deltaproteobacteria	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
TH2_k127_90846_3	481448.Minf_1745	4.472e-66	229.0	COG0440@1|root,COG0440@2|Bacteria,46SUP@74201|Verrucomicrobia,37GJ7@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	E	ACT domain	ilvH	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
TH2_k127_90846_0	926561.KB900618_gene261	6.269e-212	672.0	COG1543@1|root,COG1543@2|Bacteria,1TPFX@1239|Firmicutes,248UF@186801|Clostridia,3WB4T@53433|Halanaerobiales	186801|Clostridia	G	Glycosyl hydrolase family 57	-	-	2.4.1.18	ko:K16149	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000	-	GH57	-	DUF1957,Glyco_hydro_57
TH2_k127_90846_4	497964.CfE428DRAFT_4931	4.53e-40	166.0	COG3330@1|root,COG3330@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4912)	-	-	-	ko:K09942	-	-	-	-	ko00000	-	-	-	DUF4912,Rho_N
TH2_k127_90846_2	395493.BegalDRAFT_1262	1.086e-70	251.0	COG5316@1|root,COG5316@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
TH2_k127_91940_4	289376.THEYE_A0281	1.451e-15	79.0	COG1862@1|root,COG1862@2|Bacteria,3J0UB@40117|Nitrospirae	40117|Nitrospirae	U	Preprotein translocase subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
TH2_k127_91940_1	497964.CfE428DRAFT_5931	7.895e-146	472.0	COG0343@1|root,COG0343@2|Bacteria,46TZR@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
TH2_k127_91940_0	452637.Oter_3568	4.072e-158	512.0	COG0621@1|root,COG0621@2|Bacteria,46S5U@74201|Verrucomicrobia,3K7CQ@414999|Opitutae	414999|Opitutae	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
TH2_k127_91940_5	635013.TherJR_1418	1.083e-14	81.0	COG1426@1|root,COG1426@2|Bacteria,1V1N7@1239|Firmicutes,24M2Q@186801|Clostridia,261QR@186807|Peptococcaceae	186801|Clostridia	S	Domain of unknown function (DUF4115)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4115,HTH_25
TH2_k127_91940_2	497964.CfE428DRAFT_0598	3.505e-87	293.0	COG0512@1|root,COG0512@2|Bacteria,46SN1@74201|Verrucomicrobia	74201|Verrucomicrobia	EH	PFAM glutamine amidotransferase class-I	-	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
TH2_k127_91940_3	794903.OPIT5_10575	2.486e-55	204.0	COG1082@1|root,COG1082@2|Bacteria,46XBZ@74201|Verrucomicrobia,3K8IZ@414999|Opitutae	414999|Opitutae	G	Xylose isomerase-like TIM barrel	-	-	5.1.3.30,5.1.3.31	ko:K18910	-	-	R10817,R10818	RC03111,RC03283	ko00000,ko01000	-	-	-	AP_endonuc_2
TH2_k127_95854_24	1122604.JONR01000014_gene287	2.133e-16	87.0	2C5AX@1|root,33J9J@2|Bacteria,1NNQH@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_95854_27	234267.Acid_1712	1.737e-12	74.0	2AQI0@1|root,31FQP@2|Bacteria,3Y83D@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_95854_13	582744.Msip34_2630	2.264e-58	209.0	2AQI0@1|root,31FQP@2|Bacteria,1RI31@1224|Proteobacteria,2VUDX@28216|Betaproteobacteria,2KMU0@206350|Nitrosomonadales	206350|Nitrosomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_95854_5	671143.DAMO_1398	2.689e-102	346.0	COG0683@1|root,COG0683@2|Bacteria,2NPSN@2323|unclassified Bacteria	2|Bacteria	E	Receptor family ligand binding region	livK	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0015711,GO:0015803,GO:0015804,GO:0015818,GO:0015820,GO:0015829,GO:0015849,GO:0016597,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0070728,GO:0071702,GO:0071705	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	iECNA114_1301.ECNA114_3569,iECSF_1327.ECSF_3279,iECs_1301.ECs4309,iEcSMS35_1347.EcSMS35_3743,iG2583_1286.G2583_4163,iSFxv_1172.SFxv_3794,iSSON_1240.SSON_3698,iS_1188.S4285,iUTI89_1310.UTI89_C3965,iYL1228.KPN_03820,iZ_1308.Z4834	Peripla_BP_6
TH2_k127_95854_8	671143.DAMO_1397	3.464e-80	278.0	COG0559@1|root,COG0559@2|Bacteria,2NP7Z@2323|unclassified Bacteria	2|Bacteria	E	Branched-chain amino acid transport system / permease component	livH	GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015190,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098713,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	iJN746.PP_4866,iSFV_1184.SFV_3460,iSF_1195.SF3475,iSFxv_1172.SFxv_3791,iS_1188.S4288	BPD_transp_2
TH2_k127_95854_11	1121451.DESAM_10111	5.074e-74	275.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,42M11@68525|delta/epsilon subdivisions,2WK66@28221|Deltaproteobacteria,2M7WR@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TH2_k127_95854_9	671143.DAMO_1396	4.573e-80	292.0	COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,2NNYG@2323|unclassified Bacteria	2|Bacteria	E	Branched-chain amino acid ATP-binding cassette transporter	livM	GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	iPC815.YPO3806,iSDY_1059.SDY_3605	ABC_tran,BCA_ABC_TP_C,BPD_transp_2,DUF3382
TH2_k127_95854_6	671143.DAMO_1395	1.232e-90	304.0	COG0410@1|root,COG0410@2|Bacteria,2NNXF@2323|unclassified Bacteria	2|Bacteria	E	ABC transporter	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TH2_k127_95854_18	344747.PM8797T_00025	6.402e-39	148.0	COG1832@1|root,COG1832@2|Bacteria,2J066@203682|Planctomycetes	203682|Planctomycetes	S	CoA-binding protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
TH2_k127_95854_7	1123508.JH636447_gene7866	4.006e-84	317.0	COG3391@1|root,COG3391@2|Bacteria,2IZ8H@203682|Planctomycetes	203682|Planctomycetes	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	FlgD_ig
TH2_k127_95854_10	661478.OP10G_2040	2.118e-74	275.0	COG1874@1|root,COG1874@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	3.2.1.23,3.2.1.81	ko:K01190,ko:K01219,ko:K12308	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Cellulase,Glyco_hydro_42,Glyco_hydro_42M
TH2_k127_95854_3	497964.CfE428DRAFT_3028	1.638e-125	411.0	COG2309@1|root,COG2309@2|Bacteria,46SHB@74201|Verrucomicrobia	74201|Verrucomicrobia	E	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_95854_15	112098.XP_008610722.1	9.574e-51	189.0	28JWG@1|root,2QSAN@2759|Eukaryota	2759|Eukaryota	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
TH2_k127_95854_12	349741.Amuc_1932	1.532e-64	236.0	COG0251@1|root,COG0251@2|Bacteria,46V5Y@74201|Verrucomicrobia,2IW47@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
TH2_k127_95854_14	330214.NIDE0511	6.318e-57	206.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	pmtA	-	2.1.1.17,2.1.1.71	ko:K00570	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00091	R01320,R02056,R03424	RC00003,RC00060,RC00181,RC00496	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
TH2_k127_95854_4	1125863.JAFN01000001_gene2969	5.562e-103	359.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	PFAM Type II secretion system protein E	gspE	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
TH2_k127_95854_0	452637.Oter_3359	0.0	1045.0	COG1643@1|root,COG1643@2|Bacteria,46TMT@74201|Verrucomicrobia,3K7J2@414999|Opitutae	414999|Opitutae	L	ATP-dependent helicase C-terminal	-	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
TH2_k127_95854_23	118163.Ple7327_1940	1.275e-16	95.0	28N1B@1|root,2ZB7I@2|Bacteria,1G011@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_95854_17	118168.MC7420_1277	5.658e-43	182.0	28N1B@1|root,2ZB7I@2|Bacteria,1G011@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_95854_20	1396141.BATP01000051_gene3318	7.335e-37	155.0	COG0457@1|root,COG0457@2|Bacteria	1396141.BATP01000051_gene3318|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_95854_25	762968.HMPREF9441_00435	4.548e-16	83.0	COG0848@1|root,COG0848@2|Bacteria,4PJHU@976|Bacteroidetes,2FRY5@200643|Bacteroidia	976|Bacteroidetes	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
TH2_k127_95854_19	595460.RRSWK_03388	8.982e-38	152.0	COG0811@1|root,COG0811@2|Bacteria	2|Bacteria	U	bacteriocin transport	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
TH2_k127_95854_32	358823.DF19_20600	3.3e-05	56.0	COG1053@1|root,COG1413@1|root,COG1053@2|Bacteria,COG1413@2|Bacteria,2GPN8@201174|Actinobacteria	201174|Actinobacteria	C	fumarate reductase	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Cohesin_HEAT,FAD_binding_2,HEAT_2,Succ_DH_flav_C
TH2_k127_95854_22	521011.Mpal_0049	9.484e-23	115.0	COG5635@1|root,arCOG02967@2157|Archaea,2Y7N5@28890|Euryarchaeota,2NARR@224756|Methanomicrobia	224756|Methanomicrobia	T	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS,NACHT
TH2_k127_95854_30	1396141.BATP01000051_gene3318	1.014e-06	63.0	COG0457@1|root,COG0457@2|Bacteria	1396141.BATP01000051_gene3318|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TH2_k127_95854_29	314230.DSM3645_24005	1.014e-06	63.0	COG1520@1|root,COG1520@2|Bacteria,2IYEA@203682|Planctomycetes	203682|Planctomycetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
TH2_k127_95854_16	521674.Plim_3613	3.067e-47	175.0	COG0551@1|root,COG0551@2|Bacteria	2|Bacteria	L	DNA topological change	-	-	-	-	-	-	-	-	-	-	-	-	NERD,zf-C4_Topoisom
TH2_k127_95854_1	1118054.CAGW01000067_gene1978	2.489e-192	611.0	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,4H9MF@91061|Bacilli,26R6D@186822|Paenibacillaceae	91061|Bacilli	C	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively	-	-	-	ko:K22187	ko00040,map00040	-	R11768	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
TH2_k127_95854_2	278957.ABEA03000197_gene431	1.836e-150	485.0	COG0673@1|root,COG0673@2|Bacteria,46SBW@74201|Verrucomicrobia,3K8TJ@414999|Opitutae	414999|Opitutae	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TH2_k127_95854_28	1123242.JH636434_gene5531	1.018e-08	68.0	2EUN2@1|root,33N3X@2|Bacteria,2J1AF@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
## 2941 queries scanned
## Total time (seconds): 84.65584635734558
## Rate: 34.74 q/s