## Sat Nov 16 00:14:32 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin27/TLS_1_bin.3.fa -m mmseqs --itype genome -o TLS_1_bin.3 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/TLS_1_bin.3 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
TLS1_k127_1022572_4	290397.Adeh_3960	1.23e-24	119.0	COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,42TMM@68525|delta/epsilon subdivisions,2WQ6S@28221|Deltaproteobacteria,2YVZ3@29|Myxococcales	28221|Deltaproteobacteria	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
TLS1_k127_1022572_3	479434.Sthe_0209	7.411e-48	181.0	COG0221@1|root,COG0221@2|Bacteria,2G6T4@200795|Chloroflexi	200795|Chloroflexi	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
TLS1_k127_1022572_2	525904.Tter_1028	3.687e-69	251.0	COG0305@1|root,COG0305@2|Bacteria	2|Bacteria	L	Participates in initiation and elongation during chromosome replication	-	-	3.6.4.12	ko:K02314,ko:K02316,ko:K17680	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03029,ko03032	-	-	-	DnaB_C,Toprim_2,Toprim_N,zf-CHC2
TLS1_k127_1022572_1	525904.Tter_0214	1.483e-156	511.0	COG0624@1|root,COG0624@2|Bacteria,2NQM8@2323|unclassified Bacteria	2|Bacteria	E	Peptidase dimerisation domain	dapE	-	3.5.1.16,3.5.1.18	ko:K01436,ko:K01438,ko:K01439	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00669,R02734,R09107	RC00064,RC00090,RC00300	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
TLS1_k127_1022572_0	309801.trd_0293	5.464e-219	687.0	COG0465@1|root,COG0465@2|Bacteria,2G5J3@200795|Chloroflexi,27XT6@189775|Thermomicrobia	189775|Thermomicrobia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH1	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,Peptidase_M41
TLS1_k127_103898_1	644966.Tmar_2189	4.685e-139	448.0	COG0481@1|root,COG0481@2|Bacteria,1TP0G@1239|Firmicutes,247V8@186801|Clostridia,3WCEY@538999|Clostridiales incertae sedis	186801|Clostridia	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
TLS1_k127_103898_4	1382306.JNIM01000001_gene3511	1.798e-72	262.0	COG0635@1|root,COG0635@2|Bacteria,2G5NK@200795|Chloroflexi	200795|Chloroflexi	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
TLS1_k127_103898_3	1521187.JPIM01000004_gene3045	2.454e-75	267.0	COG1420@1|root,COG1420@2|Bacteria,2G6AQ@200795|Chloroflexi,374VS@32061|Chloroflexia	32061|Chloroflexia	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA
TLS1_k127_103898_7	309801.trd_1639	8.475e-30	126.0	COG0576@1|root,COG0576@2|Bacteria,2G6WR@200795|Chloroflexi,27YDX@189775|Thermomicrobia	189775|Thermomicrobia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
TLS1_k127_103898_0	525904.Tter_1750	1.261e-256	807.0	COG0443@1|root,COG0443@2|Bacteria,2NNU1@2323|unclassified Bacteria	2|Bacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
TLS1_k127_103898_2	309801.trd_A0345	4.129e-113	381.0	COG0168@1|root,COG0168@2|Bacteria,2G8FV@200795|Chloroflexi,27YUG@189775|Thermomicrobia	189775|Thermomicrobia	P	Cation transport protein	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
TLS1_k127_103898_5	479434.Sthe_2986	2.096e-61	220.0	COG0569@1|root,COG0569@2|Bacteria,2G8TE@200795|Chloroflexi,27YS6@189775|Thermomicrobia	189775|Thermomicrobia	C	TrkA-C domain	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
TLS1_k127_103898_6	748247.AZKH_0571	2.337e-35	154.0	COG1575@1|root,COG1575@2|Bacteria,1MXQQ@1224|Proteobacteria,2VJX1@28216|Betaproteobacteria,2KVGA@206389|Rhodocyclales	206389|Rhodocyclales	H	COG1575 1,4-dihydroxy-2-naphthoate octaprenyltransferase	-	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
TLS1_k127_103898_9	1194972.MVAC_27249	3.469e-07	58.0	COG0748@1|root,COG0748@2|Bacteria,2IBET@201174|Actinobacteria,23914@1762|Mycobacteriaceae	201174|Actinobacteria	P	coenzyme F420 binding	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS1_k127_103898_8	1120949.KB903305_gene7174	8.562e-20	90.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4DAC8@85008|Micromonosporales	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	nodI	-	-	ko:K09695	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC_tran
TLS1_k127_1045609_8	1297617.JPJD01000067_gene2201	3.286e-18	84.0	COG0050@1|root,COG0050@2|Bacteria,1TPKC@1239|Firmicutes,2485I@186801|Clostridia,267PG@186813|unclassified Clostridiales	186801|Clostridia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
TLS1_k127_1045609_6	1382306.JNIM01000001_gene3761	2.885e-52	208.0	COG0566@1|root,COG0566@2|Bacteria,2G6FR@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
TLS1_k127_1045609_2	187272.Mlg_1810	1.023e-123	413.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,1RP5K@1236|Gammaproteobacteria,1WW6E@135613|Chromatiales	135613|Chromatiales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
TLS1_k127_1045609_5	665942.HMPREF1022_00397	2.313e-53	213.0	COG0245@1|root,COG1211@1|root,COG0245@2|Bacteria,COG1211@2|Bacteria,1MVHA@1224|Proteobacteria,42MJ6@68525|delta/epsilon subdivisions,2WJ67@28221|Deltaproteobacteria,2M8C9@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
TLS1_k127_1045609_3	485913.Krac_11275	1.654e-87	302.0	COG4956@1|root,COG4956@2|Bacteria,2G5YK@200795|Chloroflexi	200795|Chloroflexi	S	SMART Nucleotide binding protein, PINc	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
TLS1_k127_1045609_1	316274.Haur_0184	1.542e-131	434.0	COG1066@1|root,COG1066@2|Bacteria,2G5TE@200795|Chloroflexi,37554@32061|Chloroflexia	32061|Chloroflexia	L	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ChlI
TLS1_k127_1045609_0	986075.CathTA2_0959	0.0	1022.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,4HACY@91061|Bacilli	91061|Bacilli	O	Belongs to the ClpA ClpB family	clpC	GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
TLS1_k127_1045609_4	469383.Cwoe_2872	6.591e-86	314.0	COG0539@1|root,COG0539@2|Bacteria,2GJAK@201174|Actinobacteria,4CPF8@84995|Rubrobacteria	84995|Rubrobacteria	J	Ribosomal protein S1-like RNA-binding domain	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
TLS1_k127_1045609_7	67267.JNXT01000028_gene1409	1.098e-29	130.0	COG0266@1|root,COG0266@2|Bacteria,2GKAM@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the FPG family	mutM1	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS1_k127_1045609_11	742823.HMPREF9465_01753	8.754e-05	53.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,2VIR7@28216|Betaproteobacteria,4PQH7@995019|Sutterellaceae	28216|Betaproteobacteria	M	Transglycosylase SLT domain	mltD	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
TLS1_k127_1056910_0	309801.trd_0861	3.959e-107	375.0	COG2262@1|root,COG2262@2|Bacteria,2G634@200795|Chloroflexi,27XK0@189775|Thermomicrobia	189775|Thermomicrobia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
TLS1_k127_1056910_4	1122175.ATXU01000004_gene2180	3.405e-51	203.0	COG0324@1|root,COG0324@2|Bacteria,2GKFT@201174|Actinobacteria,4FKAI@85023|Microbacteriaceae	201174|Actinobacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
TLS1_k127_1056910_1	309801.trd_0354	4.293e-104	360.0	COG0621@1|root,COG0621@2|Bacteria,2G5QK@200795|Chloroflexi,27Y2T@189775|Thermomicrobia	189775|Thermomicrobia	H	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
TLS1_k127_1056910_3	1120950.KB892760_gene5731	4.279e-85	289.0	COG0861@1|root,COG0861@2|Bacteria,2GRV3@201174|Actinobacteria	201174|Actinobacteria	P	Membrane protein TerC	-	-	-	-	-	-	-	-	-	-	-	-	TerC
TLS1_k127_1056910_5	479434.Sthe_0705	1.854e-46	188.0	COG0613@1|root,COG0613@2|Bacteria,2G6H4@200795|Chloroflexi,27YVQ@189775|Thermomicrobia	189775|Thermomicrobia	S	DNA polymerase alpha chain like domain	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
TLS1_k127_1056910_2	429009.Adeg_1474	1.705e-85	295.0	COG1692@1|root,COG1692@2|Bacteria,1TR9P@1239|Firmicutes,24967@186801|Clostridia,42EQD@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM Metallophosphoesterase	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
TLS1_k127_1056910_7	443906.CMM_2463	2.477e-35	147.0	2DE8Q@1|root,2ZKZK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_1056910_6	717605.Theco_2024	1.055e-41	154.0	COG1418@1|root,COG1418@2|Bacteria,1TP48@1239|Firmicutes,4HC9J@91061|Bacilli,26RXS@186822|Paenibacillaceae	91061|Bacilli	S	Endoribonuclease that initiates mRNA decay	rny	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
TLS1_k127_1085222_11	290397.Adeh_3709	1.51e-55	198.0	COG0477@1|root,COG2814@2|Bacteria,1NE49@1224|Proteobacteria,42PR8@68525|delta/epsilon subdivisions,2WK8J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS1_k127_1085222_0	351160.RCIX1517	6.016e-224	726.0	COG2217@1|root,arCOG02763@1|root,arCOG01576@2157|Archaea,arCOG02763@2157|Archaea,2XT3T@28890|Euryarchaeota,2N94W@224756|Methanomicrobia	224756|Methanomicrobia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
TLS1_k127_1085222_4	1382356.JQMP01000004_gene326	7.581e-127	420.0	COG0160@1|root,COG0160@2|Bacteria,2G5SK@200795|Chloroflexi,27XJH@189775|Thermomicrobia	189775|Thermomicrobia	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS1_k127_1085222_7	1380356.JNIK01000013_gene4060	4.959e-93	315.0	COG1230@1|root,COG1230@2|Bacteria,2GMRZ@201174|Actinobacteria,4EVBE@85013|Frankiales	201174|Actinobacteria	P	Cation efflux family	-	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
TLS1_k127_1085222_1	246197.MXAN_2612	4.672e-185	592.0	COG0122@1|root,COG2169@1|root,COG0122@2|Bacteria,COG2169@2|Bacteria,1QTXM@1224|Proteobacteria,42N8C@68525|delta/epsilon subdivisions,2WM3N@28221|Deltaproteobacteria,2YUFY@29|Myxococcales	28221|Deltaproteobacteria	K	AlkA N-terminal domain	-	-	3.2.2.21	ko:K13529,ko:K13530	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,AlkA_N,HTH_18,HhH-GPD
TLS1_k127_1085222_19	360911.EAT1b_0173	2.278e-25	117.0	COG1765@1|root,COG1765@2|Bacteria,1V7SN@1239|Firmicutes,4HIEM@91061|Bacilli	91061|Bacilli	O	redox protein regulator of disulfide bond formation	yhfA	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
TLS1_k127_1085222_26	1156937.MFUM_550025	2.848e-16	85.0	COG0589@1|root,COG0589@2|Bacteria,46WHB@74201|Verrucomicrobia,37GYA@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS1_k127_1085222_23	391037.Sare_4810	9.198e-22	104.0	COG0789@1|root,COG4978@1|root,COG0789@2|Bacteria,COG4978@2|Bacteria,2GMG7@201174|Actinobacteria,4DDUD@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like,MerR,MerR_1
TLS1_k127_1085222_22	204669.Acid345_1929	3.326e-22	106.0	COG2606@1|root,COG2606@2|Bacteria,3Y54I@57723|Acidobacteria	57723|Acidobacteria	S	Aminoacyl-tRNA editing domain	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
TLS1_k127_1085222_2	1172188.KB911820_gene2445	7.255e-172	555.0	COG2403@1|root,COG2403@2|Bacteria,2IF9H@201174|Actinobacteria,4FEFF@85021|Intrasporangiaceae	201174|Actinobacteria	S	cyclic 2,3-diphosphoglycerate synthetase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_1085222_15	1397693.KK211187_gene2622	6.216e-37	152.0	COG0726@1|root,COG1388@1|root,COG0726@2|Bacteria,COG1388@2|Bacteria,1V6DN@1239|Firmicutes,4HCJW@91061|Bacilli,3WFKX@539002|Bacillales incertae sedis	91061|Bacilli	GM	Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Cu_amine_oxidN1,LysM,Polysacc_deac_1
TLS1_k127_1085222_27	882083.SacmaDRAFT_2578	1.762e-15	81.0	COG0640@1|root,COG0640@2|Bacteria,2IKPW@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator, arsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
TLS1_k127_1085222_21	351607.Acel_0525	2.808e-22	104.0	COG2210@1|root,COG2210@2|Bacteria,2IFXH@201174|Actinobacteria,4EWZZ@85013|Frankiales	201174|Actinobacteria	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
TLS1_k127_1085222_25	292.DM42_266	2.468e-17	90.0	COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,2VVW5@28216|Betaproteobacteria,1K98X@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Belongs to the sulfur carrier protein TusA family	sirA	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
TLS1_k127_1085222_12	101510.RHA1_ro11228	3.804e-50	186.0	COG2210@1|root,COG2210@2|Bacteria,2HGHZ@201174|Actinobacteria,4FXJI@85025|Nocardiaceae	201174|Actinobacteria	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
TLS1_k127_1085222_24	565033.GACE_0532	2.036e-21	101.0	COG0425@1|root,arCOG02062@2157|Archaea,2XZUG@28890|Euryarchaeota,246G4@183980|Archaeoglobi	183980|Archaeoglobi	O	Sulfurtransferase TusA	-	-	-	-	-	-	-	-	-	-	-	-	TusA
TLS1_k127_1085222_3	326427.Cagg_3437	3.83e-135	443.0	COG0446@1|root,COG0446@2|Bacteria,2G6GM@200795|Chloroflexi,376R0@32061|Chloroflexia	200795|Chloroflexi	S	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TLS1_k127_1085222_20	266117.Rxyl_3070	2.372e-24	114.0	COG0589@1|root,COG0589@2|Bacteria,2GSJK@201174|Actinobacteria,4CQXK@84995|Rubrobacteria	201174|Actinobacteria	T	COG COG0589 Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms	uspA2	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS1_k127_1085222_28	1343740.M271_28240	9.259e-07	61.0	COG1396@1|root,COG1396@2|Bacteria,2GNQ9@201174|Actinobacteria	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3,HTH_31,TPR_12,TPR_16,TPR_8
TLS1_k127_1085222_29	1005048.CFU_2694	0.0002281	47.0	COG1396@1|root,COG1917@1|root,COG1396@2|Bacteria,COG1917@2|Bacteria,1RBF3@1224|Proteobacteria,2WEAY@28216|Betaproteobacteria,478WQ@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	Cro/C1-type HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3,HTH_31
TLS1_k127_1085222_18	351607.Acel_2041	2.106e-28	119.0	COG3585@1|root,COG3585@2|Bacteria,2IKQV@201174|Actinobacteria,4ET46@85013|Frankiales	201174|Actinobacteria	H	DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,MerR,TOBE
TLS1_k127_1085222_17	502025.Hoch_4307	3.88e-36	152.0	COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,430T4@68525|delta/epsilon subdivisions,2WVNQ@28221|Deltaproteobacteria,2YVQX@29|Myxococcales	28221|Deltaproteobacteria	P	Bacterial extracellular solute-binding protein	modA	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
TLS1_k127_1085222_10	243230.DR_A0168	1.062e-67	241.0	COG0555@1|root,COG0555@2|Bacteria,1WN1B@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	Binding-protein-dependent transport system inner membrane component	modB	-	-	ko:K02018,ko:K02046	ko00920,ko02010,map00920,map02010	M00185,M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3,3.A.1.8	-	-	BPD_transp_1
TLS1_k127_1085222_16	926569.ANT_13300	1.022e-36	160.0	COG0642@1|root,COG2203@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,2GA77@200795|Chloroflexi	200795|Chloroflexi	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_9
TLS1_k127_1085222_6	404589.Anae109_1335	2.438e-93	310.0	COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,43BC6@68525|delta/epsilon subdivisions,2X255@28221|Deltaproteobacteria,2YY92@29|Myxococcales	28221|Deltaproteobacteria	C	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	-	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
TLS1_k127_1085222_13	290399.Arth_3672	1.063e-46	171.0	COG0346@1|root,COG0346@2|Bacteria,2IM43@201174|Actinobacteria	201174|Actinobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS1_k127_1085222_5	446468.Ndas_4904	3.337e-126	414.0	COG1085@1|root,COG1085@2|Bacteria,2I2DM@201174|Actinobacteria,4EH1Q@85012|Streptosporangiales	201174|Actinobacteria	C	Galactose-1-phosphate uridyl transferase, C-terminal domain	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
TLS1_k127_1085222_8	1134912.AJTV01000021_gene3005	6.022e-93	318.0	COG0153@1|root,COG0153@2|Bacteria,1MVQD@1224|Proteobacteria,2U2RP@28211|Alphaproteobacteria,36ZV4@31993|Methylocystaceae	28211|Alphaproteobacteria	G	Galactokinase galactose-binding signature	galK	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
TLS1_k127_1085222_9	1382356.JQMP01000003_gene1700	4.219e-87	304.0	COG0449@1|root,COG0449@2|Bacteria,2G5V6@200795|Chloroflexi,27XY2@189775|Thermomicrobia	189775|Thermomicrobia	M	SIS domain	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	SIS
TLS1_k127_1085222_14	324602.Caur_1110	1.221e-37	148.0	COG1472@1|root,COG1472@2|Bacteria,2G8JU@200795|Chloroflexi	200795|Chloroflexi	G	PFAM glycoside hydrolase, family 3 domain protein	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
TLS1_k127_1092064_6	665959.HMPREF1013_01618	6.95e-06	52.0	COG5336@1|root,COG5336@2|Bacteria,1VF5M@1239|Firmicutes,4HNYV@91061|Bacilli,1ZJ1K@1386|Bacillus	91061|Bacilli	S	Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter	-	-	-	-	-	-	-	-	-	-	-	-	ATPase_gene1
TLS1_k127_1092064_1	311424.DhcVS_497	5.268e-34	145.0	COG0356@1|root,COG0356@2|Bacteria,2G6NF@200795|Chloroflexi,34D35@301297|Dehalococcoidia	301297|Dehalococcoidia	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
TLS1_k127_1092064_4	1382306.JNIM01000001_gene204	3.527e-09	61.0	COG0636@1|root,COG0636@2|Bacteria,2G72D@200795|Chloroflexi	200795|Chloroflexi	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
TLS1_k127_1092064_3	1449126.JQKL01000005_gene871	9.916e-14	79.0	COG0711@1|root,COG0711@2|Bacteria,1VB85@1239|Firmicutes,24RWR@186801|Clostridia,269VX@186813|unclassified Clostridiales	186801|Clostridia	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iHN637.CLJU_RS01170	ATP-synt_B
TLS1_k127_1092064_2	479434.Sthe_1424	1.006e-27	126.0	COG0712@1|root,COG0712@2|Bacteria,2G78B@200795|Chloroflexi,27YHC@189775|Thermomicrobia	189775|Thermomicrobia	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
TLS1_k127_1092064_0	525904.Tter_0065	3.807e-215	693.0	COG0056@1|root,COG0056@2|Bacteria,2NP0S@2323|unclassified Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	iIT341.HP1134,iSB619.SA_RS10975,iSbBS512_1146.SbBS512_E4187	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
TLS1_k127_1092064_5	583355.Caka_2110	4.489e-07	52.0	COG0224@1|root,COG0224@2|Bacteria,46SGU@74201|Verrucomicrobia,3K742@414999|Opitutae	414999|Opitutae	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
TLS1_k127_1098823_11	1137271.AZUM01000001_gene1618	4.587e-05	46.0	COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria,4DX8K@85010|Pseudonocardiales	201174|Actinobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS1_k127_1098823_3	266117.Rxyl_0877	8.085e-90	313.0	COG0793@1|root,COG0793@2|Bacteria,2GKRP@201174|Actinobacteria,4CPMI@84995|Rubrobacteria	84995|Rubrobacteria	M	tail specific protease	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
TLS1_k127_1098823_6	13035.Dacsa_2083	3.496e-44	172.0	COG2912@1|root,COG2912@2|Bacteria,1G11S@1117|Cyanobacteria	1117|Cyanobacteria	S	COGs COG2912 conserved	-	-	-	-	-	-	-	-	-	-	-	-	TPR_9,Transglut_core2
TLS1_k127_1098823_1	518766.Rmar_1671	7.404e-127	413.0	COG2897@1|root,COG2897@2|Bacteria,4NF85@976|Bacteroidetes,1FJSZ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
TLS1_k127_1098823_8	298654.FraEuI1c_2028	1.016e-15	91.0	COG0454@1|root,COG0456@2|Bacteria,2GVT5@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
TLS1_k127_1098823_0	1386089.N865_16750	1.143e-142	462.0	COG3191@1|root,COG3191@2|Bacteria,2H89D@201174|Actinobacteria,4FGPH@85021|Intrasporangiaceae	201174|Actinobacteria	EQ	Peptidase family S58	-	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
TLS1_k127_1098823_2	1397528.Q671_01420	1.79e-102	352.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1XIBD@135619|Oceanospirillales	135619|Oceanospirillales	EH	COG0147 Anthranilate para-aminobenzoate synthases component I	pabB	-	2.6.1.85	ko:K01665	ko00790,map00790	-	R01716	RC00010,RC01418	ko00000,ko00001,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
TLS1_k127_1098823_5	266117.Rxyl_0760	3.093e-44	184.0	COG0115@1|root,COG0115@2|Bacteria,2GN5Z@201174|Actinobacteria	201174|Actinobacteria	EH	Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
TLS1_k127_1098823_4	1122223.KB890687_gene2464	1.606e-77	282.0	COG4805@1|root,COG4805@2|Bacteria,1WM4J@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_1098823_9	67356.KL575611_gene3753	1.878e-13	77.0	2EGCD@1|root,33A46@2|Bacteria,2GIVH@201174|Actinobacteria	201174|Actinobacteria	S	Septum formation	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190,Septum_form
TLS1_k127_1098823_10	1321775.HMPREF1980_01357	5.373e-12	78.0	2EGCD@1|root,33A46@2|Bacteria,2HKQI@201174|Actinobacteria,4D5II@85005|Actinomycetales	201174|Actinobacteria	S	Septum formation	-	-	-	-	-	-	-	-	-	-	-	-	Septum_form
TLS1_k127_1098823_7	1380356.JNIK01000011_gene1743	6.086e-32	141.0	COG0454@1|root,COG0456@2|Bacteria,2IKW6@201174|Actinobacteria,4EVF9@85013|Frankiales	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS1_k127_1098823_12	237368.SCABRO_00546	0.0001281	53.0	COG2442@1|root,COG2442@2|Bacteria,2J4DY@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
TLS1_k127_1125930_1	378806.STAUR_5497	3.513e-220	697.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2YY8V@29|Myxococcales	28221|Deltaproteobacteria	CJ	CoA binding domain	acs	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
TLS1_k127_1125930_27	1151122.AQYD01000006_gene2382	4.338e-05	53.0	2A1Z3@1|root,30Q8Q@2|Bacteria,2GZRX@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_1125930_25	1463853.JOHW01000017_gene5286	6.143e-15	82.0	COG1917@1|root,COG1917@2|Bacteria,2IHSV@201174|Actinobacteria	201174|Actinobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS1_k127_1125930_18	186497.PF1763	1.505e-45	178.0	COG1163@1|root,arCOG00358@2157|Archaea,2XTYK@28890|Euryarchaeota,242M3@183968|Thermococci	183968|Thermococci	S	gtp1 obg	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,MMR_HSR1_Xtn,TGS
TLS1_k127_1125930_7	1298863.AUEP01000006_gene3414	1.009e-66	241.0	COG1680@1|root,COG1680@2|Bacteria,2GIX5@201174|Actinobacteria,4DRSP@85009|Propionibacteriales	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS1_k127_1125930_13	693977.Deipr_1336	3.122e-52	202.0	COG0477@1|root,COG2814@2|Bacteria,1WIWD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS1_k127_1125930_22	1385520.N802_13110	2.892e-41	164.0	2BYEJ@1|root,3395P@2|Bacteria,2GQ9D@201174|Actinobacteria,4FIMC@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_1125930_3	1160137.KB907308_gene6609	1.029e-129	433.0	COG2114@1|root,COG2114@2|Bacteria,2GJRI@201174|Actinobacteria,4FWTA@85025|Nocardiaceae	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
TLS1_k127_1125930_4	1380347.JNII01000005_gene3108	1.532e-79	276.0	COG1917@1|root,COG2114@1|root,COG1917@2|Bacteria,COG2114@2|Bacteria,2IASU@201174|Actinobacteria	201174|Actinobacteria	IT	Pfam Adenylate and Guanylate cyclase catalytic domain	lipJ	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Guanylate_cyc
TLS1_k127_1125930_8	749414.SBI_03948	3.452e-59	208.0	COG0346@1|root,COG0346@2|Bacteria,2IKKR@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS1_k127_1125930_6	570268.ANBB01000058_gene4269	6.448e-71	249.0	COG0431@1|root,COG0431@2|Bacteria,2IHWU@201174|Actinobacteria,4EIMU@85012|Streptosporangiales	201174|Actinobacteria	S	NADPH-dependent FMN reductase	ssuE	-	1.5.1.38	ko:K00299	ko00740,ko00920,ko01100,map00740,map00920,map01100	-	R05706,R07210,R10206	RC00126,RC01779,RC02556	ko00000,ko00001,ko01000	-	-	-	FMN_red
TLS1_k127_1125930_2	1449976.KALB_6041	1.04e-216	675.0	COG2141@1|root,COG2141@2|Bacteria,2GKCU@201174|Actinobacteria,4DYKX@85010|Pseudonocardiales	201174|Actinobacteria	C	luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS1_k127_1125930_10	479435.Kfla_0703	7.499e-54	203.0	COG0346@1|root,COG0346@2|Bacteria,2IKTR@201174|Actinobacteria,4DV29@85009|Propionibacteriales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS1_k127_1125930_16	452863.Achl_0884	1.472e-48	183.0	COG3476@1|root,COG3476@2|Bacteria,2IQA5@201174|Actinobacteria,1W9UZ@1268|Micrococcaceae	201174|Actinobacteria	T	TspO/MBR family	-	-	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
TLS1_k127_1125930_19	1123319.AUBE01000001_gene1851	2.372e-45	175.0	COG0346@1|root,COG0346@2|Bacteria,2IM7G@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS1_k127_1125930_15	443906.CMM_2875	5.877e-49	179.0	COG0572@1|root,COG0572@2|Bacteria,2I69G@201174|Actinobacteria,4FTPF@85023|Microbacteriaceae	201174|Actinobacteria	F	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
TLS1_k127_1125930_24	715226.ABI_06470	2.006e-24	113.0	COG5646@1|root,COG5646@2|Bacteria,1NKMZ@1224|Proteobacteria,2UJHW@28211|Alphaproteobacteria,2KJ5I@204458|Caulobacterales	204458|Caulobacterales	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
TLS1_k127_1125930_23	196162.Noca_3357	8.605e-41	163.0	COG3153@1|root,COG3153@2|Bacteria,2I5C0@201174|Actinobacteria	201174|Actinobacteria	S	Acetyltransferase (GNAT) domain	-	-	2.3.1.59	ko:K17840	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_9
TLS1_k127_1125930_21	1120934.KB894423_gene2695	1.378e-43	161.0	COG0640@1|root,COG0640@2|Bacteria,2IKQY@201174|Actinobacteria,4E4JT@85010|Pseudonocardiales	201174|Actinobacteria	K	PFAM Bacterial regulatory protein, arsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
TLS1_k127_1125930_11	469371.Tbis_1015	1.999e-52	207.0	COG3832@1|root,COG3832@2|Bacteria,2IHTJ@201174|Actinobacteria,4E53R@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS1_k127_1125930_14	675635.Psed_0313	2.248e-51	188.0	COG0346@1|root,COG0346@2|Bacteria,2IKTR@201174|Actinobacteria,4E4PD@85010|Pseudonocardiales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS1_k127_1125930_9	471853.Bcav_3749	4.295e-57	207.0	COG3832@1|root,COG3832@2|Bacteria,2IQUJ@201174|Actinobacteria	201174|Actinobacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS1_k127_1125930_20	477641.MODMU_1098	2.187e-44	165.0	COG0346@1|root,COG0346@2|Bacteria,2IS2C@201174|Actinobacteria,4EWD7@85013|Frankiales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS1_k127_1125930_17	525904.Tter_1713	6.282e-48	186.0	COG1680@1|root,COG1680@2|Bacteria,2NRI6@2323|unclassified Bacteria	2|Bacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS1_k127_1125930_12	485913.Krac_4435	2.823e-52	193.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS1_k127_1125930_0	215803.DB30_1363	0.0	1148.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42M4I@68525|delta/epsilon subdivisions,2WJHM@28221|Deltaproteobacteria,2YU81@29|Myxococcales	28221|Deltaproteobacteria	L	ABC transporter	snorO	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS1_k127_1125930_5	1242864.D187_003088	1.887e-79	284.0	COG2931@1|root,COG3055@1|root,COG2931@2|Bacteria,COG3055@2|Bacteria,1Q4PQ@1224|Proteobacteria,4347S@68525|delta/epsilon subdivisions,2X34Y@28221|Deltaproteobacteria,2YUAC@29|Myxococcales	28221|Deltaproteobacteria	V	Kelch motif	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_1,Kelch_4,TSP_3
TLS1_k127_1155706_0	525904.Tter_0081	1.257e-212	674.0	COG3808@1|root,COG3808@2|Bacteria,2NNK9@2323|unclassified Bacteria	2|Bacteria	C	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
TLS1_k127_1155706_10	1380393.JHVP01000004_gene714	8.159e-59	213.0	COG1968@1|root,COG1968@2|Bacteria,2GJVG@201174|Actinobacteria,4EU19@85013|Frankiales	201174|Actinobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
TLS1_k127_1155706_14	429009.Adeg_1395	1.299e-29	126.0	COG1438@1|root,COG1438@2|Bacteria,1V1R7@1239|Firmicutes,24HGQ@186801|Clostridia,42GDW@68295|Thermoanaerobacterales	186801|Clostridia	K	Regulates arginine biosynthesis genes	argR	-	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
TLS1_k127_1155706_5	937777.Deipe_2373	3.558e-91	318.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS1_k127_1155706_4	926554.KI912647_gene1801	4.32e-110	374.0	COG4813@1|root,COG4813@2|Bacteria	2|Bacteria	G	Trehalose utilization protein	thuA	-	-	-	-	-	-	-	-	-	-	-	ThuA
TLS1_k127_1155706_13	767817.Desgi_0317	7.348e-40	156.0	COG0782@1|root,COG0782@2|Bacteria,1V44S@1239|Firmicutes,24HP9@186801|Clostridia,261HN@186807|Peptococcaceae	186801|Clostridia	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
TLS1_k127_1155706_3	497964.CfE428DRAFT_6224	1.836e-125	436.0	COG1384@1|root,COG1384@2|Bacteria	2|Bacteria	J	tRNA binding	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
TLS1_k127_1155706_2	861299.J421_3175	2.133e-130	434.0	COG0172@1|root,COG0172@2|Bacteria,1ZT0V@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
TLS1_k127_1155706_16	56780.SYN_02280	1.714e-17	92.0	COG1714@1|root,COG1714@2|Bacteria,1MZAD@1224|Proteobacteria,43B7B@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	DUF4339,RDD
TLS1_k127_1155706_9	1118054.CAGW01000048_gene1617	9.84e-68	239.0	COG0454@1|root,COG0456@2|Bacteria,1V40T@1239|Firmicutes,4HI2H@91061|Bacilli,26YNM@186822|Paenibacillaceae	91061|Bacilli	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS1_k127_1155706_6	1267535.KB906767_gene1580	1.779e-81	289.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	MA20_17390	-	-	ko:K00713,ko:K06338	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS1_k127_1155706_7	1298863.AUEP01000004_gene2227	4.785e-79	278.0	COG0646@1|root,COG0646@2|Bacteria,2IEWZ@201174|Actinobacteria	201174|Actinobacteria	E	Homocysteine S-methyltransferase	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
TLS1_k127_1155706_15	298654.FraEuI1c_3888	7.518e-27	118.0	COG0025@1|root,COG0025@2|Bacteria,2I2S7@201174|Actinobacteria	201174|Actinobacteria	P	Zn-finger in ubiquitin-hydrolases and other protein	-	-	-	-	-	-	-	-	-	-	-	-	zf-UBP
TLS1_k127_1155706_8	1303518.CCALI_02593	3.556e-76	279.0	COG2199@1|root,COG2206@1|root,COG2206@2|Bacteria,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3369,GGDEF,HD,HD_5,HisKA_7TM,Response_reg
TLS1_k127_1155706_1	309801.trd_0102	1.884e-130	434.0	COG0147@1|root,COG0147@2|Bacteria,2G5M7@200795|Chloroflexi,27XZ8@189775|Thermomicrobia	189775|Thermomicrobia	H	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
TLS1_k127_1155706_11	1380347.JNII01000011_gene909	2.119e-55	207.0	COG0512@1|root,COG0512@2|Bacteria,2GJUX@201174|Actinobacteria,4ESDU@85013|Frankiales	201174|Actinobacteria	EH	TIGRFAM glutamine amidotransferase of anthranilate synthase	trpG	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
TLS1_k127_1155706_12	552811.Dehly_0496	1.092e-47	191.0	COG0547@1|root,COG0547@2|Bacteria,2G5YV@200795|Chloroflexi,34CJV@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	-	-	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
TLS1_k127_1155709_1	1121468.AUBR01000008_gene2047	1.013e-50	191.0	COG0105@1|root,COG0105@2|Bacteria,1V44G@1239|Firmicutes,24JM5@186801|Clostridia,42G92@68295|Thermoanaerobacterales	186801|Clostridia	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
TLS1_k127_1155709_3	1121013.P873_09450	2.243e-08	68.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,1RPJB@1236|Gammaproteobacteria,1X3KC@135614|Xanthomonadales	135614|Xanthomonadales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TLS1_k127_1155709_2	768706.Desor_2674	1.539e-30	132.0	COG0681@1|root,COG0681@2|Bacteria,1V7H9@1239|Firmicutes,24HHW@186801|Clostridia,2650P@186807|Peptococcaceae	186801|Clostridia	U	TIGRFAM signal peptidase I, bacterial type	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
TLS1_k127_1155709_0	243164.DET0766	6.647e-150	489.0	COG3808@1|root,COG3808@2|Bacteria,2G5N7@200795|Chloroflexi,34CNJ@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	-	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
TLS1_k127_1176995_8	1128421.JAGA01000002_gene1407	7.865e-05	48.0	COG2968@1|root,COG2968@2|Bacteria,2NR4Z@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function (DUF541)	lpqG	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
TLS1_k127_1176995_1	649638.Trad_2090	1.148e-116	391.0	COG2133@1|root,COG2133@2|Bacteria,1WJQY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	PFAM Glucose Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
TLS1_k127_1176995_7	228410.NE0622	5.025e-32	134.0	COG0662@1|root,COG0662@2|Bacteria,1RFTK@1224|Proteobacteria,2WG1F@28216|Betaproteobacteria,374QB@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS1_k127_1176995_4	404589.Anae109_3016	5.282e-41	167.0	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,43BI9@68525|delta/epsilon subdivisions,2X6WN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
TLS1_k127_1176995_6	365528.KB891208_gene3008	5.845e-33	148.0	COG1846@1|root,COG1846@2|Bacteria,2IJHQ@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator (MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
TLS1_k127_1176995_0	357808.RoseRS_3113	3.718e-132	435.0	COG0520@1|root,COG0520@2|Bacteria,2G5W7@200795|Chloroflexi,375CE@32061|Chloroflexia	32061|Chloroflexia	E	TIGRFAM cysteine desulfurase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS1_k127_1176995_5	1283299.AUKG01000001_gene3562	7.387e-37	157.0	COG0665@1|root,COG0665@2|Bacteria	2|Bacteria	E	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DAO
TLS1_k127_1176995_3	479434.Sthe_2593	2.269e-66	236.0	COG1834@1|root,COG1834@2|Bacteria,2G7QT@200795|Chloroflexi,27YZU@189775|Thermomicrobia	189775|Thermomicrobia	E	Amidinotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf
TLS1_k127_1176995_2	211114.JOEF01000031_gene1880	6.022e-74	275.0	COG0624@1|root,COG0624@2|Bacteria,2I8IJ@201174|Actinobacteria,4E29D@85010|Pseudonocardiales	201174|Actinobacteria	E	Peptidase dimerisation domain	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS1_k127_1184474_0	309801.trd_1669	1.382e-38	157.0	COG2197@1|root,COG2197@2|Bacteria,2G6K0@200795|Chloroflexi,27Y3S@189775|Thermomicrobia	189775|Thermomicrobia	K	Two component transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS1_k127_1184474_1	443255.SCLAV_p0824	1.703e-24	116.0	COG2911@1|root,COG2911@2|Bacteria,2IFIC@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF642)	-	-	-	-	-	-	-	-	-	-	-	-	DUF642
TLS1_k127_1204362_0	103733.JNYO01000002_gene343	1.146e-48	194.0	COG3540@1|root,COG3540@2|Bacteria,2GNZ5@201174|Actinobacteria,4DXI0@85010|Pseudonocardiales	201174|Actinobacteria	P	PhoD-like phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	PhoD
TLS1_k127_1227853_0	1128421.JAGA01000002_gene1149	8.246e-160	524.0	COG4770@1|root,COG4770@2|Bacteria	2|Bacteria	I	CoA carboxylase activity	-	-	6.4.1.4	ko:K01968	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
TLS1_k127_1227853_5	485913.Krac_6815	4.975e-88	302.0	COG0119@1|root,COG0119@2|Bacteria,2G7M0@200795|Chloroflexi	200795|Chloroflexi	E	PFAM pyruvate carboxyltransferase	-	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
TLS1_k127_1227853_8	525904.Tter_0978	8.632e-53	209.0	COG1403@1|root,COG1403@2|Bacteria,2NPJD@2323|unclassified Bacteria	2|Bacteria	L	HNH endonuclease	MA20_20605	-	-	-	-	-	-	-	-	-	-	-	HNH,HNH_5
TLS1_k127_1227853_3	1254432.SCE1572_07805	8.372e-100	343.0	COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,42N0S@68525|delta/epsilon subdivisions,2WMJK@28221|Deltaproteobacteria,2Z3CT@29|Myxococcales	28221|Deltaproteobacteria	H	tRNA nucleotidyltransferase domain 2 putative	-	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
TLS1_k127_1227853_15	889378.Spiaf_1634	0.0002001	52.0	COG0457@1|root,COG0457@2|Bacteria,2J5SR@203691|Spirochaetes	203691|Spirochaetes	S	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC3,TPR_16,TPR_19,TPR_6,TPR_8
TLS1_k127_1227853_4	497964.CfE428DRAFT_2042	3.344e-98	334.0	COG1087@1|root,COG1087@2|Bacteria,46SIR@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
TLS1_k127_1227853_7	1128421.JAGA01000002_gene1840	3.335e-70	257.0	COG2270@1|root,COG2270@2|Bacteria,2NP3G@2323|unclassified Bacteria	2|Bacteria	S	Vacuole effluxer Atg22 like	yxiO	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22,MFS_1
TLS1_k127_1227853_14	1172180.KB911778_gene5040	0.0001602	52.0	COG1793@1|root,COG1793@2|Bacteria,2I2EA@201174|Actinobacteria	201174|Actinobacteria	L	dna ligase	ligC	-	-	-	-	-	-	-	-	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
TLS1_k127_1227853_2	330214.NIDE4207	2.181e-113	391.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	2.4.1.268	ko:K21349	-	-	-	-	ko00000,ko01000	-	GT81	-	Glycos_transf_2
TLS1_k127_1227853_1	1128421.JAGA01000003_gene2709	6.499e-133	456.0	COG0589@1|root,COG1215@1|root,COG0589@2|Bacteria,COG1215@2|Bacteria,2NNSB@2323|unclassified Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	gpgS	-	2.4.1.266,2.4.1.268	ko:K09118,ko:K13693,ko:K21349	-	-	-	-	ko00000,ko01000,ko01003	-	GT81	-	Glycos_transf_2,Usp
TLS1_k127_1227853_6	338966.Ppro_2915	2.894e-78	276.0	COG1929@1|root,COG1929@2|Bacteria,1MVG9@1224|Proteobacteria,42MRF@68525|delta/epsilon subdivisions,2WNGJ@28221|Deltaproteobacteria,43UUK@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Belongs to the glycerate kinase type-1 family	glxK	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
TLS1_k127_1227853_10	316274.Haur_2402	6.148e-46	187.0	COG0177@1|root,COG0177@2|Bacteria,2G6A1@200795|Chloroflexi,375YQ@32061|Chloroflexia	32061|Chloroflexia	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
TLS1_k127_1227853_9	1380390.JIAT01000009_gene1863	3.052e-46	176.0	COG0745@1|root,COG0745@2|Bacteria,2GKFS@201174|Actinobacteria,4CU2Q@84995|Rubrobacteria	84995|Rubrobacteria	K	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS1_k127_1227853_12	379066.GAU_2888	1.642e-25	123.0	COG0642@1|root,COG2205@2|Bacteria,1ZUG2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Domain of unknown function (DUF4118)	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA
TLS1_k127_1227853_11	521011.Mpal_1810	3.56e-33	145.0	COG3291@1|root,arCOG02554@1|root,arCOG02559@1|root,arCOG02508@2157|Archaea,arCOG02510@2157|Archaea,arCOG02554@2157|Archaea,arCOG02559@2157|Archaea,2Y7Y8@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	PKD
TLS1_k127_1227853_13	525904.Tter_1023	8.592e-08	59.0	COG4961@1|root,COG4961@2|Bacteria	2|Bacteria	U	PFAM TadE family protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
TLS1_k127_1248022_1	1125863.JAFN01000001_gene1869	1.272e-53	199.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,42M1G@68525|delta/epsilon subdivisions,2WJ7V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Phenylalanyl-tRNA synthetase, beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
TLS1_k127_1248022_0	644966.Tmar_0836	9.915e-107	357.0	COG0016@1|root,COG0016@2|Bacteria,1TPFW@1239|Firmicutes,2486E@186801|Clostridia,3WCC5@538999|Clostridiales incertae sedis	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
TLS1_k127_1248022_2	1127673.GLIP_1528	2.497e-16	79.0	COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,1S3P3@1236|Gammaproteobacteria,466ZJ@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	GO:0000027,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2000113,GO:2001141	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
TLS1_k127_1341796_13	1121272.KB903272_gene462	0.0006651	42.0	COG1409@1|root,COG1409@2|Bacteria,2GIT1@201174|Actinobacteria,4DM0J@85008|Micromonosporales	201174|Actinobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
TLS1_k127_1341796_4	525904.Tter_0760	2.598e-60	217.0	COG2220@1|root,COG2220@2|Bacteria,2NPQC@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the UPF0173 family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Lactamase_B_2,Lactamase_B_3
TLS1_k127_1341796_0	479434.Sthe_3342	1.146e-258	815.0	COG2217@1|root,COG2217@2|Bacteria,2G5S4@200795|Chloroflexi,27YT0@189775|Thermomicrobia	189775|Thermomicrobia	P	E1-E2 ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase
TLS1_k127_1341796_7	867903.ThesuDRAFT_00783	6.345e-42	171.0	COG0314@1|root,COG1977@1|root,COG0314@2|Bacteria,COG1977@2|Bacteria,1V3V0@1239|Firmicutes,24QVX@186801|Clostridia	186801|Clostridia	H	Molybdopterin converting factor subunit	-	-	2.8.1.12	ko:K03635,ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE,ThiS
TLS1_k127_1341796_6	1123320.KB889561_gene4824	2.359e-49	186.0	COG2362@1|root,COG2362@2|Bacteria,2GK6A@201174|Actinobacteria	201174|Actinobacteria	E	D-aminopeptidase	-	-	-	ko:K16203	-	-	-	-	ko00000,ko01000,ko01002	3.A.1.5.2	-	-	Peptidase_M55
TLS1_k127_1341796_10	1111479.AXAR01000002_gene1940	7.046e-22	111.0	COG0274@1|root,COG0274@2|Bacteria,1TPA0@1239|Firmicutes,4HFFT@91061|Bacilli	91061|Bacilli	F	D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit	-	-	-	-	-	-	-	-	-	-	-	-	Lys-AminoMut_A
TLS1_k127_1341796_11	331869.BAL199_10145	1.313e-17	89.0	COG1977@1|root,COG1977@2|Bacteria,1N0ZW@1224|Proteobacteria,2UCKF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
TLS1_k127_1341796_3	1121033.AUCF01000008_gene5705	2.106e-142	477.0	COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2U0UY@28211|Alphaproteobacteria,2JRNW@204441|Rhodospirillales	204441|Rhodospirillales	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_1341796_1	869210.Marky_1612	2.549e-238	754.0	COG0365@1|root,COG0365@2|Bacteria,1WIHG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	AMP-dependent synthetase and ligase	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
TLS1_k127_1341796_2	1380391.JIAS01000014_gene2112	2.952e-193	616.0	COG5598@1|root,COG5598@2|Bacteria,1MX73@1224|Proteobacteria,2TS1M@28211|Alphaproteobacteria,2JVS6@204441|Rhodospirillales	204441|Rhodospirillales	H	Trimethylamine methyltransferase (MTTB)	-	-	-	-	-	-	-	-	-	-	-	-	MTTB
TLS1_k127_1341796_5	265072.Mfla_0007	5.378e-54	198.0	COG5637@1|root,COG5637@2|Bacteria,1RCEX@1224|Proteobacteria,2VQP4@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
TLS1_k127_1341796_9	526227.Mesil_2849	9.304e-27	123.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,1WM3F@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_3,PAS_4,PAS_8
TLS1_k127_1341796_8	1089545.KB913037_gene3025	1.229e-34	144.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4E1KK@85010|Pseudonocardiales	201174|Actinobacteria	KT	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS1_k127_1342467_1	351607.Acel_0397	7.839e-110	370.0	COG2352@1|root,COG2352@2|Bacteria,2GKDB@201174|Actinobacteria,4ERFY@85013|Frankiales	201174|Actinobacteria	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
TLS1_k127_1342467_12	525909.Afer_1639	3.273e-07	61.0	COG3340@1|root,COG3340@2|Bacteria,2HH0B@201174|Actinobacteria,4CP0Q@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Peptidase family S51	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S51
TLS1_k127_1342467_7	1051632.TPY_1705	4.276e-38	158.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS1_k127_1342467_4	479434.Sthe_2180	2.383e-53	199.0	COG0842@1|root,COG0842@2|Bacteria,2G8GV@200795|Chloroflexi,27Y6U@189775|Thermomicrobia	189775|Thermomicrobia	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS1_k127_1342467_3	309801.trd_1149	1.252e-63	246.0	COG1131@1|root,COG1131@2|Bacteria,2G7SA@200795|Chloroflexi,27XY4@189775|Thermomicrobia	189775|Thermomicrobia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS1_k127_1342467_9	684949.ATTJ01000001_gene785	2.876e-25	111.0	COG0526@1|root,COG0526@2|Bacteria,1WJ2P@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	CO	periplasmic protein thiol disulfide oxidoreductases, DsbE subfamily	-	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA
TLS1_k127_1342467_13	521011.Mpal_0675	5.877e-05	55.0	COG2133@1|root,arCOG03441@1|root,arCOG02796@2157|Archaea,arCOG03441@2157|Archaea,2XT1Q@28890|Euryarchaeota	28890|Euryarchaeota	G	COG2133 Glucose sorbosone dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1,GSDH
TLS1_k127_1342467_6	1033806.HTIA_0486	2.25e-40	160.0	COG1845@1|root,arCOG04650@2157|Archaea,2XTFU@28890|Euryarchaeota,23SSB@183963|Halobacteria	183963|Halobacteria	C	COG1845 Heme copper-type cytochrome quinol oxidase, subunit 3	coxC	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
TLS1_k127_1342467_0	1273125.Rrhod_2383	1.781e-211	670.0	COG0843@1|root,COG0843@2|Bacteria,2GJHX@201174|Actinobacteria,4FV1E@85025|Nocardiaceae	201174|Actinobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
TLS1_k127_1342467_8	33876.JNXY01000013_gene4023	2.15e-37	159.0	COG1622@1|root,COG1622@2|Bacteria,2GNXA@201174|Actinobacteria,4D8RY@85008|Micromonosporales	201174|Actinobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	ctaC	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0040007,GO:0042773,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044281,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0051704,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM
TLS1_k127_1342467_5	1121946.AUAX01000001_gene2105	3.289e-52	202.0	COG3336@1|root,COG3336@2|Bacteria,2GKIR@201174|Actinobacteria,4D95Z@85008|Micromonosporales	201174|Actinobacteria	S	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)	-	-	-	ko:K02351,ko:K07245	-	-	-	-	ko00000,ko02000	9.B.62.1	-	-	Caa3_CtaG
TLS1_k127_1342467_2	1382359.JIAL01000001_gene561	1.342e-88	312.0	COG1171@1|root,COG1171@2|Bacteria,3Y2UN@57723|Acidobacteria,2JI1Z@204432|Acidobacteriia	204432|Acidobacteriia	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS1_k127_1342467_10	2002.JOEQ01000006_gene1300	9.071e-15	79.0	COG1734@1|root,COG1734@2|Bacteria,2GJBE@201174|Actinobacteria,4EJJN@85012|Streptosporangiales	201174|Actinobacteria	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
TLS1_k127_1342467_11	1168059.KB899087_gene2450	4.658e-08	63.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,3EYZK@335928|Xanthobacteraceae	28211|Alphaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
TLS1_k127_1352980_0	471854.Dfer_1756	0.0	1579.0	COG1749@1|root,COG3386@1|root,COG1749@2|Bacteria,COG3386@2|Bacteria,4NTUT@976|Bacteroidetes	976|Bacteroidetes	N	Domain of unknown function (DUF4082)	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE,DUF4082
TLS1_k127_1352980_1	479433.Caci_5077	5.869e-51	211.0	COG4257@1|root,COG4257@2|Bacteria,2I6PD@201174|Actinobacteria	201174|Actinobacteria	V	Domain of unknown function (DUF4082)	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF4082
TLS1_k127_1379197_12	316274.Haur_0377	6.165e-51	183.0	COG0035@1|root,COG0035@2|Bacteria,2G6CS@200795|Chloroflexi,3754Q@32061|Chloroflexia	32061|Chloroflexia	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	-	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
TLS1_k127_1379197_17	477641.MODMU_4596	1.858e-21	103.0	COG3860@1|root,COG3860@2|Bacteria,2IQEK@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2087)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2087,HTH_20
TLS1_k127_1379197_9	351607.Acel_1040	7.064e-74	259.0	COG1028@1|root,COG1028@2|Bacteria,2I6UQ@201174|Actinobacteria,4EVQ5@85013|Frankiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
TLS1_k127_1379197_10	330084.JNYZ01000005_gene1195	2.315e-60	220.0	COG0662@1|root,COG0662@2|Bacteria,2GN99@201174|Actinobacteria	201174|Actinobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS1_k127_1379197_13	1380390.JIAT01000011_gene2301	1.675e-49	188.0	COG1396@1|root,COG1396@2|Bacteria,2IC4C@201174|Actinobacteria,4CT6V@84995|Rubrobacteria	84995|Rubrobacteria	K	Cro/C1-type HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS1_k127_1379197_0	285514.JNWO01000001_gene4733	1.726e-189	602.0	COG0006@1|root,COG0006@2|Bacteria,2H45Q@201174|Actinobacteria	201174|Actinobacteria	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
TLS1_k127_1379197_4	105422.BBPM01000060_gene4257	9.575e-139	458.0	COG1071@1|root,COG1071@2|Bacteria,2GK3W@201174|Actinobacteria,2NNCT@228398|Streptacidiphilus	201174|Actinobacteria	C	Dehydrogenase E1 component	acoA	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
TLS1_k127_1379197_2	285535.JOEY01000038_gene2762	4.771e-148	481.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria	201174|Actinobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
TLS1_k127_1379197_8	351607.Acel_1045	1.907e-75	267.0	COG2084@1|root,COG2084@2|Bacteria,2GNB0@201174|Actinobacteria,4EWCI@85013|Frankiales	201174|Actinobacteria	I	PFAM 6-phosphogluconate dehydrogenase NAD-binding	-	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
TLS1_k127_1379197_3	463191.SSEG_09288	6.104e-147	494.0	COG0402@1|root,COG0402@2|Bacteria,2GNUN@201174|Actinobacteria	201174|Actinobacteria	F	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS1_k127_1379197_7	1313172.YM304_14090	2.77e-99	338.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	thiY	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
TLS1_k127_1379197_15	1463855.JOHV01000020_gene3022	1.623e-47	190.0	COG0600@1|root,COG0600@2|Bacteria,2IFIB@201174|Actinobacteria	201174|Actinobacteria	P	inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
TLS1_k127_1379197_6	1121381.JNIV01000043_gene1803	2.5e-99	331.0	COG1116@1|root,COG1116@2|Bacteria,1WM71@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	ABC-type nitrate sulfonate bicarbonate transport system ATPase component	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
TLS1_k127_1379197_11	1463855.JOHV01000020_gene3024	4.432e-53	200.0	COG0600@1|root,COG0600@2|Bacteria,2HDX7@201174|Actinobacteria	201174|Actinobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
TLS1_k127_1379197_1	1121918.ARWE01000001_gene385	1.477e-164	530.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,42MFC@68525|delta/epsilon subdivisions,2WTRK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Aminotransferase class-III	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
TLS1_k127_1379197_18	1173026.Glo7428_4961	4.194e-15	86.0	COG5654@1|root,COG5654@2|Bacteria,1GBKD@1117|Cyanobacteria	1117|Cyanobacteria	S	RES	-	-	-	-	-	-	-	-	-	-	-	-	RES
TLS1_k127_1379197_14	927677.ALVU02000001_gene2370	6.249e-48	194.0	COG1597@1|root,COG1597@2|Bacteria,1G0MV@1117|Cyanobacteria	1117|Cyanobacteria	I	PFAM Diacylglycerol kinase, catalytic	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
TLS1_k127_1379197_16	479434.Sthe_0331	4.659e-44	173.0	COG0671@1|root,COG0671@2|Bacteria,2G8YH@200795|Chloroflexi,27YK3@189775|Thermomicrobia	189775|Thermomicrobia	I	Acid phosphatase homologues	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
TLS1_k127_1379197_5	1121272.KB903249_gene1783	5.845e-134	444.0	COG0388@1|root,COG0388@2|Bacteria,2GKRJ@201174|Actinobacteria,4D96X@85008|Micromonosporales	201174|Actinobacteria	S	Carbon-nitrogen hydrolase	-	-	3.5.1.6	ko:K01431	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R00905,R04666,R08228	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase
TLS1_k127_1450512_0	469371.Tbis_0314	5.746e-167	533.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GKXV@201174|Actinobacteria,4DXF9@85010|Pseudonocardiales	201174|Actinobacteria	C	ferredoxin oxidoreductase	porA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
TLS1_k127_1450512_1	530564.Psta_0806	1.281e-142	461.0	COG1013@1|root,COG1013@2|Bacteria,2IY6Z@203682|Planctomycetes	203682|Planctomycetes	C	COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
TLS1_k127_1450512_11	1210884.HG799462_gene8483	1.522e-22	113.0	COG0517@1|root,COG0517@2|Bacteria,2J0MQ@203682|Planctomycetes	203682|Planctomycetes	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS1_k127_1450512_4	1120950.KB892708_gene4447	5.407e-101	346.0	COG0006@1|root,COG0006@2|Bacteria,2GM7D@201174|Actinobacteria,4DNDZ@85009|Propionibacteriales	201174|Actinobacteria	E	Creatinase/Prolidase N-terminal domain	pepE	-	3.4.13.9,3.5.3.3	ko:K01271,ko:K01274,ko:K08688	ko00260,ko00330,ko01100,map00260,map00330,map01100	-	R01566	RC00548,RC00549	ko00000,ko00001,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
TLS1_k127_1450512_7	479435.Kfla_0454	3.044e-45	173.0	COG0664@1|root,COG0664@2|Bacteria,2GMPN@201174|Actinobacteria,4DMXW@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix, cAMP Regulatory protein	glxR	GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
TLS1_k127_1450512_9	1449346.JQMO01000003_gene2673	1.059e-24	115.0	COG2203@1|root,COG2203@2|Bacteria,2I97I@201174|Actinobacteria,2M5MY@2063|Kitasatospora	201174|Actinobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2
TLS1_k127_1450512_5	1463856.JOHY01000013_gene6158	8.151e-72	254.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Peptidase_S8,TIG
TLS1_k127_1450512_10	1155718.KB891854_gene3002	2.477e-24	120.0	COG0350@1|root,COG0350@2|Bacteria,2GKA9@201174|Actinobacteria	201174|Actinobacteria	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
TLS1_k127_1450512_12	395961.Cyan7425_4893	2.67e-08	67.0	COG0664@1|root,COG0664@2|Bacteria,1G02U@1117|Cyanobacteria,3KGDV@43988|Cyanothece	1117|Cyanobacteria	K	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
TLS1_k127_1450512_8	1123388.AQWU01000031_gene1411	7.962e-32	143.0	COG0477@1|root,COG2814@2|Bacteria,1WIZD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
TLS1_k127_1450512_2	309801.trd_A0447	2.262e-142	463.0	COG0304@1|root,COG0304@2|Bacteria,2G5K7@200795|Chloroflexi,27Y13@189775|Thermomicrobia	189775|Thermomicrobia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TLS1_k127_1450512_3	357808.RoseRS_3468	2.206e-114	395.0	COG0304@1|root,COG0304@2|Bacteria,2G5K7@200795|Chloroflexi,374W7@32061|Chloroflexia	32061|Chloroflexia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TLS1_k127_1450512_6	991905.SL003B_2405	8.707e-64	229.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,2TRTT@28211|Alphaproteobacteria,4BPBU@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	malonyl CoA-acyl carrier protein transacylase	fabD	GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
TLS1_k127_1479398_12	494419.ALPM01000012_gene679	9.16e-09	63.0	COG2815@1|root,COG2815@2|Bacteria,2I4T0@201174|Actinobacteria,1WCNM@1268|Micrococcaceae	201174|Actinobacteria	S	PASTA	-	-	-	-	-	-	-	-	-	-	-	-	PASTA
TLS1_k127_1479398_13	1006004.GBAG_3158	3.483e-05	56.0	COG2373@1|root,COG3420@1|root,COG4932@1|root,COG2373@2|Bacteria,COG3420@2|Bacteria,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria,1T2KS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG3209 Rhs family protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,Big_3_3
TLS1_k127_1479398_4	649638.Trad_1462	1.889e-68	254.0	COG0285@1|root,COG0285@2|Bacteria,1WI0C@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	PFAM Mur ligase family, glutamate ligase domain	-	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
TLS1_k127_1479398_2	1382356.JQMP01000003_gene1503	4.786e-82	300.0	COG0294@1|root,COG0294@2|Bacteria,2G6A6@200795|Chloroflexi,27XJT@189775|Thermomicrobia	189775|Thermomicrobia	H	Pterin binding enzyme	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
TLS1_k127_1479398_9	264732.Moth_0407	5.975e-27	116.0	COG1539@1|root,COG1539@2|Bacteria,1VA0I@1239|Firmicutes,24MN5@186801|Clostridia,42H0U@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folB	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
TLS1_k127_1479398_3	479434.Sthe_0612	2.043e-70	258.0	COG0265@1|root,COG0265@2|Bacteria,2G8RK@200795|Chloroflexi,27Y6G@189775|Thermomicrobia	200795|Chloroflexi	M	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	1.3.1.74,3.4.21.107	ko:K04771,ko:K08070	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
TLS1_k127_1479398_6	292459.STH3289	7.502e-46	187.0	COG0642@1|root,COG2205@2|Bacteria,1V10X@1239|Firmicutes,24P7E@186801|Clostridia	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,sCache_like
TLS1_k127_1479398_5	552398.HMPREF0866_01412	2.559e-64	227.0	COG0745@1|root,COG0745@2|Bacteria,1TPQG@1239|Firmicutes,248Z4@186801|Clostridia,3WIDV@541000|Ruminococcaceae	186801|Clostridia	T	response regulator receiver	walR	-	-	ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS1_k127_1479398_8	1128421.JAGA01000001_gene2186	4.547e-33	138.0	COG1825@1|root,COG1825@2|Bacteria,2NPVU@2323|unclassified Bacteria	2|Bacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
TLS1_k127_1479398_11	877455.Metbo_1756	1.595e-11	77.0	arCOG01792@1|root,arCOG01792@2157|Archaea	2157|Archaea	K	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS1_k127_1479398_0	1192034.CAP_5178	4.201e-187	601.0	COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	malic protein domain protein	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
TLS1_k127_1479398_10	67332.FM21_20035	5.856e-24	116.0	COG1579@1|root,COG1579@2|Bacteria,2I2XU@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
TLS1_k127_1479398_7	765420.OSCT_0224	3.081e-38	166.0	COG0642@1|root,COG2205@2|Bacteria,2G8TQ@200795|Chloroflexi,377EU@32061|Chloroflexia	32061|Chloroflexia	T	Domain of unknown function (DUF4173)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4173
TLS1_k127_1479398_1	404589.Anae109_4038	3.206e-147	471.0	COG1793@1|root,COG1793@2|Bacteria,1R4SI@1224|Proteobacteria,438FV@68525|delta/epsilon subdivisions,2X3QT@28221|Deltaproteobacteria,2YWVJ@29|Myxococcales	28221|Deltaproteobacteria	L	ATP dependent DNA ligase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
TLS1_k127_1483345_13	266117.Rxyl_2065	3.136e-67	248.0	COG0583@1|root,COG0583@2|Bacteria,2GK13@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS1_k127_1483345_0	1380386.JIAW01000010_gene4303	0.0	1032.0	COG2224@1|root,COG2224@2|Bacteria,2I926@201174|Actinobacteria,232A9@1762|Mycobacteriaceae	201174|Actinobacteria	C	Isocitrate lyase	aceAb	GO:0003674,GO:0003824,GO:0004451,GO:0005975,GO:0006081,GO:0006082,GO:0006097,GO:0006102,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046421,GO:0046487,GO:0071704,GO:0072350	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	ICL
TLS1_k127_1483345_2	509190.Cseg_3982	5.348e-177	579.0	COG1554@1|root,COG1554@2|Bacteria,1MWJE@1224|Proteobacteria,2U1CG@28211|Alphaproteobacteria,2KHXJ@204458|Caulobacterales	204458|Caulobacterales	G	Glycosyl hydrolase family 65 central catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_65N,Glyco_hydro_65m
TLS1_k127_1483345_21	644966.Tmar_0494	1.11e-12	76.0	COG4454@1|root,COG4454@2|Bacteria	2|Bacteria	-	-	copC	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1,SoxE
TLS1_k127_1483345_19	452863.Achl_1114	8.611e-16	90.0	2AFVV@1|root,33H4H@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_1483345_14	557599.MKAN_17465	3.581e-64	235.0	COG0665@1|root,COG0665@2|Bacteria,2GW0W@201174|Actinobacteria	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
TLS1_k127_1483345_17	517418.Ctha_0365	1.367e-23	113.0	COG0673@1|root,COG0673@2|Bacteria,1FEZX@1090|Chlorobi	1090|Chlorobi	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS1_k127_1483345_16	357808.RoseRS_2370	2.312e-60	218.0	COG2148@1|root,COG2148@2|Bacteria,2G66B@200795|Chloroflexi,376EB@32061|Chloroflexia	32061|Chloroflexia	M	PFAM sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
TLS1_k127_1483345_15	479434.Sthe_2816	6.222e-62	223.0	COG1878@1|root,COG1878@2|Bacteria,2G8PN@200795|Chloroflexi,27Y5C@189775|Thermomicrobia	189775|Thermomicrobia	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
TLS1_k127_1483345_7	1163408.UU9_16606	2.126e-107	361.0	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,1RP9W@1236|Gammaproteobacteria,1X532@135614|Xanthomonadales	135614|Xanthomonadales	K	transcriptional regulator	ftrA	-	-	ko:K13633	-	-	-	-	ko00000,ko03000	-	-	-	DJ-1_PfpI,HTH_18
TLS1_k127_1483345_20	224325.AF_1672	1.119e-13	76.0	COG4747@1|root,arCOG04444@2157|Archaea,2XXTI@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM amino acid-binding ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ACT
TLS1_k127_1483345_18	1128421.JAGA01000004_gene2488	4.508e-23	110.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS1_k127_1483345_10	760568.Desku_1497	2.074e-91	325.0	COG1690@1|root,COG1690@2|Bacteria,1TPJ2@1239|Firmicutes,2481V@186801|Clostridia,265QP@186807|Peptococcaceae	186801|Clostridia	S	tRNA-splicing ligase RtcB	-	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
TLS1_k127_1483345_11	1232410.KI421412_gene319	1.718e-90	317.0	COG0297@1|root,COG0366@1|root,COG0297@2|Bacteria,COG0366@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2WITI@28221|Deltaproteobacteria,43U7I@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Starch synthase catalytic domain	glgA-2	GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0055114,GO:0071704,GO:1901576	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Alpha-amylase,Glyco_transf_5,Glycos_transf_1
TLS1_k127_1483345_1	521045.Kole_0242	1.113e-193	632.0	COG0058@1|root,COG0058@2|Bacteria,2GCCY@200918|Thermotogae	200918|Thermotogae	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
TLS1_k127_1483345_3	1089550.ATTH01000001_gene2060	1.884e-142	472.0	COG0366@1|root,COG0366@2|Bacteria,4PIQU@976|Bacteroidetes,1FJWV@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	Alpha-amylase domain	-	-	3.2.1.133,3.2.1.135,3.2.1.54	ko:K01208	ko00500,ko01100,map00500,map01100	-	R02112,R03122,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
TLS1_k127_1483345_4	357808.RoseRS_0014	6.486e-139	464.0	COG0366@1|root,COG0366@2|Bacteria,2G5NW@200795|Chloroflexi,376G5@32061|Chloroflexia	32061|Chloroflexia	G	SMART alpha amylase, catalytic sub domain	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
TLS1_k127_1483345_8	867845.KI911784_gene2328	6.337e-99	332.0	COG0395@1|root,COG3833@1|root,COG0395@2|Bacteria,COG3833@2|Bacteria,2G8IJ@200795|Chloroflexi,3772H@32061|Chloroflexia	32061|Chloroflexia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K15772	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
TLS1_k127_1483345_9	316274.Haur_4564	9.461e-96	336.0	COG1175@1|root,COG1175@2|Bacteria,2G8NE@200795|Chloroflexi,376MA@32061|Chloroflexia	32061|Chloroflexia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K15771	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
TLS1_k127_1483345_6	324602.Caur_0496	1.037e-112	379.0	COG2182@1|root,COG2182@2|Bacteria,2G74H@200795|Chloroflexi,376QQ@32061|Chloroflexia	32061|Chloroflexia	G	PFAM extracellular solute-binding protein family 1	-	-	-	ko:K15770	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	SBP_bac_8
TLS1_k127_1483345_12	357808.RoseRS_2559	5.926e-81	287.0	COG1609@1|root,COG1609@2|Bacteria,2GAIK@200795|Chloroflexi,377B5@32061|Chloroflexia	32061|Chloroflexia	K	periplasmic binding protein LacI transcriptional regulator	-	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	LacI,Peripla_BP_3
TLS1_k127_1483345_5	485913.Krac_6715	1.508e-128	425.0	COG1449@1|root,COG1449@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 57 family	amyA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.4.1.25	ko:K22451	ko00500,map00500	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH57	-	DUF1925,DUF1926,Glyco_hydro_57
TLS1_k127_1484095_1	426117.M446_6222	1.69e-48	193.0	COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,2U0AU@28211|Alphaproteobacteria,1JS2Q@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS1_k127_1484095_0	1121875.KB907549_gene1768	2.017e-87	309.0	COG0642@1|root,COG2199@1|root,COG3292@1|root,COG2205@2|Bacteria,COG3292@2|Bacteria,COG3706@2|Bacteria,4NG28@976|Bacteroidetes,1I1IG@117743|Flavobacteriia	976|Bacteroidetes	KT	regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Reg_prop,Y_Y_Y
TLS1_k127_1484095_4	402777.KB235904_gene4083	1.217e-24	116.0	COG2114@1|root,COG2203@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,1G3VK@1117|Cyanobacteria,1HA0X@1150|Oscillatoriales	1117|Cyanobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF_2,Guanylate_cyc
TLS1_k127_1484095_2	1267533.KB906738_gene2355	8.252e-44	165.0	COG0745@1|root,COG0745@2|Bacteria	1267533.KB906738_gene2355|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_1484095_3	290397.Adeh_2455	5.571e-33	144.0	COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,42MZY@68525|delta/epsilon subdivisions,2WJWT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
TLS1_k127_15375_1	1111479.AXAR01000003_gene1713	9.604e-127	413.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,4H9QB@91061|Bacilli,277YF@186823|Alicyclobacillaceae	91061|Bacilli	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
TLS1_k127_15375_9	1172180.KB911777_gene1799	1.282e-17	91.0	COG1514@1|root,COG1514@2|Bacteria,2IKSA@201174|Actinobacteria	201174|Actinobacteria	J	2'-5' RNA ligase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2_5_RNA_ligase2
TLS1_k127_15375_7	926569.ANT_02700	1.901e-33	135.0	COG0346@1|root,COG0346@2|Bacteria,2G79M@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
TLS1_k127_15375_6	1382356.JQMP01000003_gene2093	4.07e-41	159.0	COG0393@1|root,COG0393@2|Bacteria,2G9VK@200795|Chloroflexi,27YJH@189775|Thermomicrobia	189775|Thermomicrobia	S	Putative heavy-metal-binding	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
TLS1_k127_15375_4	391037.Sare_2394	6.797e-87	295.0	COG2227@1|root,COG2227@2|Bacteria,2GM1S@201174|Actinobacteria,4DMGR@85008|Micromonosporales	201174|Actinobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS1_k127_15375_2	1128421.JAGA01000003_gene3002	9.372e-118	389.0	COG0074@1|root,COG0074@2|Bacteria,2NNZD@2323|unclassified Bacteria	2|Bacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
TLS1_k127_15375_3	880073.Calab_0629	3.1e-99	338.0	COG0045@1|root,COG0045@2|Bacteria,2NNQA@2323|unclassified Bacteria	2|Bacteria	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
TLS1_k127_15375_0	1121430.JMLG01000005_gene762	9.974e-152	487.0	COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia,260YV@186807|Peptococcaceae	186801|Clostridia	C	PFAM isocitrate isopropylmalate dehydrogenase	icd	-	1.1.1.41,1.1.1.83,1.1.1.93,4.1.1.73	ko:K00030,ko:K07246	ko00020,ko00630,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00650,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00215,R00709,R01751,R02545,R06180	RC00084,RC00105,RC00114,RC00594	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TLS1_k127_15375_8	309801.trd_0333	2.463e-24	108.0	COG2009@1|root,COG2009@2|Bacteria,2G7CW@200795|Chloroflexi,27YF5@189775|Thermomicrobia	189775|Thermomicrobia	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	-	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
TLS1_k127_15375_10	644966.Tmar_0119	1.053e-15	86.0	COG2142@1|root,COG2142@2|Bacteria,1VP1A@1239|Firmicutes,24XAD@186801|Clostridia	186801|Clostridia	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	-	-	-	ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
TLS1_k127_15375_5	525904.Tter_0785	5.121e-56	199.0	COG1053@1|root,COG1053@2|Bacteria,2NNR9@2323|unclassified Bacteria	2|Bacteria	C	succinate dehydrogenase, flavoprotein subunit	sdhA	GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071704,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0072350,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	iE2348C_1286.E2348C_0603,iJN746.PP_4191,iPC815.YPO1111	FAD_binding_2,Succ_DH_flav_C
TLS1_k127_1572865_1	357808.RoseRS_3299	1.73e-156	512.0	COG0578@1|root,COG0578@2|Bacteria,2G63S@200795|Chloroflexi,3750F@32061|Chloroflexia	32061|Chloroflexia	C	BFD domain protein 2Fe-2S -binding domain protein	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,Fer2_BFD
TLS1_k127_1572865_0	326427.Cagg_0072	1.268e-263	820.0	COG0554@1|root,COG0554@2|Bacteria,2G5TV@200795|Chloroflexi,3751K@32061|Chloroflexia	32061|Chloroflexia	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
TLS1_k127_1572865_4	383372.Rcas_2043	7.363e-98	328.0	COG0580@1|root,COG0580@2|Bacteria,2G813@200795|Chloroflexi,376PT@32061|Chloroflexia	32061|Chloroflexia	G	Belongs to the MIP aquaporin (TC 1.A.8) family	-	-	-	ko:K02440	-	-	-	-	ko00000,ko02000	1.A.8.1,1.A.8.2	-	-	MIP
TLS1_k127_1572865_19	1288079.AUKN01000002_gene5704	1.617e-05	55.0	COG1954@1|root,COG1954@2|Bacteria,2I51S@201174|Actinobacteria	201174|Actinobacteria	K	Glycerol-3-phosphate responsive antiterminator	-	-	-	ko:K02443	-	-	-	-	ko00000,ko03000	-	-	-	G3P_antiterm
TLS1_k127_1572865_16	748224.HMPREF9436_02052	2.317e-24	110.0	COG1954@1|root,COG1954@2|Bacteria,1V4IE@1239|Firmicutes,24HDM@186801|Clostridia,3WQAQ@541000|Ruminococcaceae	186801|Clostridia	K	Glycerol-3-phosphate responsive antiterminator	glpP	-	-	ko:K02443	-	-	-	-	ko00000,ko03000	-	-	-	G3P_antiterm
TLS1_k127_1572865_2	562970.Btus_1769	6.51e-134	451.0	COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,4HAJ6@91061|Bacilli,278SV@186823|Alicyclobacillaceae	91061|Bacilli	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
TLS1_k127_1572865_8	1273103.NM10_10585	2.636e-53	200.0	COG0539@1|root,COG0761@1|root,COG0539@2|Bacteria,COG0761@2|Bacteria,1TQ9N@1239|Firmicutes,4H2B6@909932|Negativicutes	909932|Negativicutes	J	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K02945,ko:K03527	ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010	M00096,M00178	R05884,R08210	RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011	-	-	-	LYTB,S1
TLS1_k127_1572865_14	671143.DAMO_1369	4.404e-32	142.0	COG0204@1|root,COG0204@2|Bacteria,2NPW3@2323|unclassified Bacteria	2|Bacteria	I	Phosphate acyltransferases	cmk	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS1_k127_1572865_9	479434.Sthe_0437	9.49e-50	186.0	COG0283@1|root,COG0283@2|Bacteria,2G6I5@200795|Chloroflexi,27YEA@189775|Thermomicrobia	189775|Thermomicrobia	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
TLS1_k127_1572865_10	1229780.BN381_290070	2.339e-47	190.0	COG1187@1|root,COG1187@2|Bacteria,2GJ4N@201174|Actinobacteria,3UWKC@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	RNA pseudouridylate synthase	rluB	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.19,5.4.99.22	ko:K06178,ko:K06183	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS1_k127_1572865_12	383372.Rcas_4453	4.026e-33	146.0	COG1386@1|root,COG1386@2|Bacteria,2G6V6@200795|Chloroflexi,375NU@32061|Chloroflexia	32061|Chloroflexia	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
TLS1_k127_1572865_17	1144275.COCOR_04131	5.185e-22	109.0	COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,42RG5@68525|delta/epsilon subdivisions,2WNRE@28221|Deltaproteobacteria,2YV06@29|Myxococcales	28221|Deltaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
TLS1_k127_1572865_18	1382306.JNIM01000001_gene3902	1.902e-15	83.0	COG1418@1|root,COG1418@2|Bacteria,2G7CI@200795|Chloroflexi	200795|Chloroflexi	S	mRNA catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_1572865_13	644282.Deba_1208	4.319e-33	136.0	COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,42STM@68525|delta/epsilon subdivisions,2WPAD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
TLS1_k127_1572865_15	765420.OSCT_1250	2.29e-30	131.0	COG3428@1|root,COG3428@2|Bacteria,2G70V@200795|Chloroflexi,375QN@32061|Chloroflexia	32061|Chloroflexia	S	PFAM membrane-flanked domain	-	-	-	-	-	-	-	-	-	-	-	-	SHOCT,bPH_2
TLS1_k127_1572865_6	1122622.ATWJ01000010_gene1174	1.195e-79	278.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4FETP@85021|Intrasporangiaceae	201174|Actinobacteria	L	recombinase XerD	xerD	GO:0008150,GO:0040007	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS1_k127_1572865_3	867903.ThesuDRAFT_00086	1.331e-107	370.0	COG0497@1|root,COG0497@2|Bacteria,1TP99@1239|Firmicutes,247KB@186801|Clostridia,3WCFS@538999|Clostridiales incertae sedis	186801|Clostridia	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
TLS1_k127_1572865_11	552811.Dehly_0367	2.735e-47	190.0	COG0061@1|root,COG0061@2|Bacteria,2G6NK@200795|Chloroflexi,34CNH@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
TLS1_k127_1572865_7	414684.RC1_0569	4.914e-67	237.0	COG1189@1|root,COG1189@2|Bacteria,1MWP5@1224|Proteobacteria,2TRW9@28211|Alphaproteobacteria,2JP9D@204441|Rhodospirillales	204441|Rhodospirillales	J	rRNA methylase	tlyA	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
TLS1_k127_1572865_5	398767.Glov_2235	6.781e-96	323.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,42M35@68525|delta/epsilon subdivisions,2WIX5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
TLS1_k127_1574976_2	479434.Sthe_2466	7.963e-76	269.0	COG0438@1|root,COG0438@2|Bacteria,2G8GB@200795|Chloroflexi,27XSA@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS1_k127_1574976_3	1128421.JAGA01000002_gene315	3.876e-50	195.0	COG0842@1|root,COG0842@2|Bacteria,2NPA6@2323|unclassified Bacteria	2|Bacteria	V	ABC-type multidrug transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
TLS1_k127_1574976_1	479434.Sthe_0418	4.41e-79	285.0	COG1131@1|root,COG1131@2|Bacteria,2G7S9@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS1_k127_1574976_0	1183438.GKIL_3693	9.331e-120	395.0	COG3569@1|root,COG3569@2|Bacteria,1G2R6@1117|Cyanobacteria	1117|Cyanobacteria	L	Eukaryotic DNA topoisomerase I, catalytic core	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_I
TLS1_k127_1574976_5	1382306.JNIM01000001_gene4082	3.734e-31	136.0	COG5002@1|root,COG5002@2|Bacteria,2G66G@200795|Chloroflexi	200795|Chloroflexi	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA,PAS
TLS1_k127_1574976_4	1123368.AUIS01000020_gene1108	1.799e-37	147.0	COG5592@1|root,COG5592@2|Bacteria,1RGUY@1224|Proteobacteria,1S5V6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Hemerythrin hhe cation binding	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
TLS1_k127_1574976_6	324602.Caur_2236	5.821e-23	104.0	COG0143@1|root,COG0143@2|Bacteria,2G6VG@200795|Chloroflexi,375Q2@32061|Chloroflexia	32061|Chloroflexia	J	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	DZR
TLS1_k127_1574976_7	1305732.JAGG01000001_gene1329	1.485e-12	72.0	COG2261@1|root,COG2261@2|Bacteria,2GQR5@201174|Actinobacteria	201174|Actinobacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
TLS1_k127_1598497_2	66692.ABC2297	5.724e-62	231.0	COG1196@1|root,COG1196@2|Bacteria,1TPJV@1239|Firmicutes,4HB89@91061|Bacilli,1ZAWM@1386|Bacillus	91061|Bacilli	D	Required for chromosome condensation and partitioning	smc	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
TLS1_k127_1598497_1	663278.Ethha_0321	1.714e-84	294.0	COG0552@1|root,COG0552@2|Bacteria,1TPRI@1239|Firmicutes,247JD@186801|Clostridia,3WGFT@541000|Ruminococcaceae	186801|Clostridia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
TLS1_k127_1598497_0	1121423.JONT01000009_gene1465	5.576e-144	472.0	COG0541@1|root,COG0541@2|Bacteria,1TP06@1239|Firmicutes,248EU@186801|Clostridia,2610F@186807|Peptococcaceae	186801|Clostridia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
TLS1_k127_1598497_3	1341151.ASZU01000004_gene102	5.133e-27	116.0	COG0228@1|root,COG0228@2|Bacteria,1VA0X@1239|Firmicutes,4HKNN@91061|Bacilli,27C4Q@186824|Thermoactinomycetaceae	91061|Bacilli	J	Ribosomal protein S16	rpsP	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
TLS1_k127_1598497_5	1410618.JNKI01000001_gene1309	1.836e-17	91.0	COG1837@1|root,COG1837@2|Bacteria,1VEG7@1239|Firmicutes,4H5NW@909932|Negativicutes	909932|Negativicutes	S	Belongs to the UPF0109 family	-	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
TLS1_k127_1598497_4	1232429.CBLL010000017_gene1176	3.958e-18	96.0	COG0806@1|root,COG0806@2|Bacteria,2GK4I@201174|Actinobacteria,1W9H0@1268|Micrococcaceae	201174|Actinobacteria	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	GO:0008150,GO:0040007	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
TLS1_k127_1666567_0	404589.Anae109_2572	4.965e-65	234.0	COG1573@1|root,COG1573@2|Bacteria,1MW8T@1224|Proteobacteria,42ZZ6@68525|delta/epsilon subdivisions,2WV5A@28221|Deltaproteobacteria,2YZAW@29|Myxococcales	28221|Deltaproteobacteria	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS1_k127_1666567_1	309801.trd_0391	2.439e-45	181.0	COG0520@1|root,COG0520@2|Bacteria,2G7JU@200795|Chloroflexi,27XQN@189775|Thermomicrobia	189775|Thermomicrobia	E	Cys/Met metabolism PLP-dependent enzyme	-	-	-	ko:K11325	-	-	-	-	ko00000	-	-	-	Aminotran_5
TLS1_k127_1676902_1	525904.Tter_0241	5.172e-86	294.0	COG0614@1|root,COG0614@2|Bacteria	2|Bacteria	P	abc-type fe3 -hydroxamate transport system, periplasmic component	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
TLS1_k127_1676902_4	1463861.JNXE01000019_gene6050	8.875e-25	120.0	COG0500@1|root,COG2226@2|Bacteria,2IAGR@201174|Actinobacteria	201174|Actinobacteria	Q	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS1_k127_1676902_0	867845.KI911784_gene836	9.235e-91	308.0	COG0345@1|root,COG0345@2|Bacteria,2G5QD@200795|Chloroflexi,375AU@32061|Chloroflexia	32061|Chloroflexia	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
TLS1_k127_1676902_6	1206730.BAGA01000145_gene140	0.0003543	52.0	28HG7@1|root,2Z7S3@2|Bacteria,2GMJK@201174|Actinobacteria,4FU3D@85025|Nocardiaceae	201174|Actinobacteria	S	Wyosine base formation	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N,Wyosine_form
TLS1_k127_1676902_3	266117.Rxyl_0312	1.742e-52	213.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2GJW4@201174|Actinobacteria,4CQV5@84995|Rubrobacteria	84995|Rubrobacteria	EU	Peptidase S9, prolyl oligopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
TLS1_k127_1676902_2	379066.GAU_2853	2.242e-80	291.0	COG0506@1|root,COG0506@2|Bacteria,1ZT6A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Proline dehydrogenase	-	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
TLS1_k127_1676902_5	1304865.JAGF01000001_gene3519	1.247e-18	93.0	2DRIE@1|root,33BXS@2|Bacteria	2|Bacteria	S	Family of unknown function (DUF5317)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5317
TLS1_k127_1683900_13	1313172.YM304_23950	2.978e-17	91.0	COG0319@1|root,COG0319@2|Bacteria,2GMUF@201174|Actinobacteria,4CN8G@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
TLS1_k127_1683900_2	479434.Sthe_0888	7.505e-113	392.0	COG1480@1|root,COG1480@2|Bacteria,2G5WC@200795|Chloroflexi,27XNG@189775|Thermomicrobia	189775|Thermomicrobia	S	7TM-HD extracellular	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
TLS1_k127_1683900_11	888060.HMPREF9081_1514	5.286e-33	134.0	COG1610@1|root,COG1610@2|Bacteria,1V6F2@1239|Firmicutes,4H4MK@909932|Negativicutes	909932|Negativicutes	S	YqeY-like protein	yqeY	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
TLS1_k127_1683900_12	525904.Tter_1056	8.231e-18	84.0	COG0828@1|root,COG0828@2|Bacteria,2NQ1U@2323|unclassified Bacteria	2|Bacteria	J	Ribosomal protein S21	rpsU	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
TLS1_k127_1683900_3	485913.Krac_12111	6.032e-109	375.0	COG1022@1|root,COG1022@2|Bacteria,2G5S9@200795|Chloroflexi	200795|Chloroflexi	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
TLS1_k127_1683900_10	1208321.D104_14175	6.705e-41	154.0	COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,1S3QE@1236|Gammaproteobacteria,1XK38@135619|Oceanospirillales	135619|Oceanospirillales	FG	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family	hinT	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	DcpS_C,HIT
TLS1_k127_1683900_5	477974.Daud_2053	4.466e-81	295.0	COG0621@1|root,COG0621@2|Bacteria,1TPBR@1239|Firmicutes,247IX@186801|Clostridia,25ZY0@186807|Peptococcaceae	186801|Clostridia	J	MiaB-like tRNA modifying enzyme	yqeV	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
TLS1_k127_1683900_7	1128421.JAGA01000002_gene824	7.657e-72	260.0	COG2264@1|root,COG2264@2|Bacteria,2NPP7@2323|unclassified Bacteria	2|Bacteria	J	Ribosomal protein L11 methyltransferase	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
TLS1_k127_1683900_1	555079.Toce_0910	5.539e-122	401.0	COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,248EM@186801|Clostridia,42ESV@68295|Thermoanaerobacterales	186801|Clostridia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
TLS1_k127_1683900_9	1151127.KB906326_gene384	3.689e-56	221.0	COG0726@1|root,COG0726@2|Bacteria,1MWMZ@1224|Proteobacteria,1RSJA@1236|Gammaproteobacteria,1YM8U@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	G	Uncharacterized protein conserved in bacteria (DUF2334)	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
TLS1_k127_1683900_6	469383.Cwoe_5791	1.565e-79	285.0	COG1573@1|root,COG1573@2|Bacteria,2GK1I@201174|Actinobacteria,4CPSB@84995|Rubrobacteria	84995|Rubrobacteria	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS1_k127_1683900_4	211114.JOEF01000001_gene7037	5.414e-88	317.0	COG0842@1|root,COG0842@2|Bacteria,2GMXR@201174|Actinobacteria,4E020@85010|Pseudonocardiales	201174|Actinobacteria	V	Transport permease protein	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
TLS1_k127_1683900_8	1122138.AQUZ01000003_gene399	7.905e-68	239.0	COG0842@1|root,COG0842@2|Bacteria,2GVC2@201174|Actinobacteria,4DQNH@85009|Propionibacteriales	201174|Actinobacteria	V	ABC-2 type transporter	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
TLS1_k127_1683900_0	351607.Acel_0744	1.231e-140	452.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4ERP0@85013|Frankiales	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	nodI	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran
TLS1_k127_1711995_5	1206731.BAGB01000037_gene9180	2.083e-46	173.0	COG1957@1|root,COG1957@2|Bacteria,2GP6N@201174|Actinobacteria,4FXA3@85025|Nocardiaceae	201174|Actinobacteria	F	Inosine-uridine preferring nucleoside hydrolase	iunH	-	3.2.2.1	ko:K01239,ko:K01250	ko00230,ko00760,ko01100,map00230,map00760,map01100	-	R01245,R01273,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	IU_nuc_hydro
TLS1_k127_1711995_6	1128421.JAGA01000001_gene2133	8.655e-44	174.0	COG3275@1|root,COG3275@2|Bacteria,2NR98@2323|unclassified Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.7.7.65	ko:K16923,ko:K18967	-	M00582	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.28,9.B.34.1.1	-	-	5TM-5TMR_LYT,ECF_trnsprt,GGDEF,HATPase_c,PAS_4,PAS_7
TLS1_k127_1711995_8	357808.RoseRS_3451	1.648e-32	137.0	COG0619@1|root,COG0619@2|Bacteria,2G7IA@200795|Chloroflexi	200795|Chloroflexi	P	PFAM Cobalt transport protein	-	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
TLS1_k127_1711995_3	334413.FMG_1444	1.669e-53	209.0	COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia,22GXG@1570339|Peptoniphilaceae	186801|Clostridia	P	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	-	-	-	ko:K02006,ko:K16786,ko:K16787	ko02010,map02010	M00245,M00246,M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.18,3.A.1.22,3.A.1.23,3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
TLS1_k127_1711995_2	1449976.KALB_2008	5.687e-71	260.0	COG1122@1|root,COG1122@2|Bacteria,2GJ0M@201174|Actinobacteria,4DYPQ@85010|Pseudonocardiales	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran,DUF3744
TLS1_k127_1711995_4	749927.AMED_7935	3.823e-48	188.0	COG0500@1|root,COG2226@2|Bacteria,2IPTP@201174|Actinobacteria,4EAQM@85010|Pseudonocardiales	201174|Actinobacteria	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS1_k127_1711995_9	867903.ThesuDRAFT_00144	1.992e-27	128.0	COG1310@1|root,COG1310@2|Bacteria,1V6TY@1239|Firmicutes,24JI8@186801|Clostridia	186801|Clostridia	S	Mov34 MPN PAD-1 family	-	-	3.13.1.6	ko:K21140	ko04122,map04122	-	R11524	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB
TLS1_k127_1711995_1	671143.DAMO_1028	8.586e-121	397.0	COG0031@1|root,COG0031@2|Bacteria,2NP1M@2323|unclassified Bacteria	2|Bacteria	E	Pyridoxal-phosphate dependent enzyme	cysM	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0033847,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.113,2.5.1.47,6.1.1.16	ko:K01883,ko:K12339,ko:K21148	ko00270,ko00920,ko00970,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04122,map00270,map00920,map00970,map01100,map01110,map01120,map01130,map01200,map01230,map04122	M00021,M00359,M00360	R00897,R03132,R03601,R03650,R04859,R10610	RC00020,RC00055,RC00523,RC02814,RC02821,RC02876,RC03225	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	PALP,tRNA-synt_1e
TLS1_k127_1711995_10	1122939.ATUD01000002_gene1254	8.612e-22	110.0	COG1977@1|root,COG1977@2|Bacteria,2IQBT@201174|Actinobacteria,4CTFG@84995|Rubrobacteria	84995|Rubrobacteria	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
TLS1_k127_1711995_0	1144275.COCOR_06186	8.167e-141	461.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,1MW7H@1224|Proteobacteria,42NEC@68525|delta/epsilon subdivisions,2WK08@28221|Deltaproteobacteria,2YUA5@29|Myxococcales	28221|Deltaproteobacteria	HP	domain protein	moeB1	-	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
TLS1_k127_1711995_7	525904.Tter_1695	2.83e-40	153.0	COG0822@1|root,COG0822@2|Bacteria,2NPXN@2323|unclassified Bacteria	2|Bacteria	C	NifU-like N terminal domain	nifU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
TLS1_k127_1717821_4	215803.DB30_0234	3.354e-74	263.0	COG1846@1|root,COG1846@2|Bacteria,1N6YD@1224|Proteobacteria,433TH@68525|delta/epsilon subdivisions,2X3E9@28221|Deltaproteobacteria,2YVPE@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
TLS1_k127_1717821_6	479435.Kfla_5854	2.512e-61	232.0	COG1670@1|root,COG1670@2|Bacteria,2GP87@201174|Actinobacteria,4DQYP@85009|Propionibacteriales	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS1_k127_1717821_8	452652.KSE_46920	4.604e-37	149.0	COG1028@1|root,COG1028@2|Bacteria,2HP88@201174|Actinobacteria	201174|Actinobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS1_k127_1717821_5	357808.RoseRS_0705	5.215e-70	244.0	COG0302@1|root,COG0302@2|Bacteria,2G6VZ@200795|Chloroflexi,375HB@32061|Chloroflexia	32061|Chloroflexia	H	PFAM GTP cyclohydrolase I	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
TLS1_k127_1717821_2	913325.N799_00630	1.644e-79	280.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RU20@1236|Gammaproteobacteria,1X9AU@135614|Xanthomonadales	135614|Xanthomonadales	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
TLS1_k127_1717821_12	1123319.AUBE01000012_gene6274	3.817e-13	79.0	COG0596@1|root,COG0596@2|Bacteria,2GNBX@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the peptidase S33 family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
TLS1_k127_1717821_9	266117.Rxyl_1027	1.341e-29	122.0	COG3824@1|root,COG3824@2|Bacteria,2IKXW@201174|Actinobacteria,4CQ0S@84995|Rubrobacteria	84995|Rubrobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
TLS1_k127_1717821_3	644966.Tmar_0092	6.002e-79	277.0	COG1171@1|root,COG1171@2|Bacteria,1TP22@1239|Firmicutes,248D5@186801|Clostridia,3WCTC@538999|Clostridiales incertae sedis	186801|Clostridia	E	Pyridoxal-phosphate dependent enzyme	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_4,PALP
TLS1_k127_1717821_1	926560.KE387027_gene1038	1.054e-112	380.0	COG2133@1|root,COG2133@2|Bacteria,1WJQY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	PFAM Glucose Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
TLS1_k127_1717821_7	1068978.AMETH_5925	2.431e-44	174.0	2E9GJ@1|root,333PP@2|Bacteria,2HC60@201174|Actinobacteria	201174|Actinobacteria	S	Lysyl oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Lysyl_oxidase
TLS1_k127_1717821_13	1266909.AUAG01000008_gene2007	4.221e-13	73.0	COG0607@1|root,COG0640@1|root,COG0607@2|Bacteria,COG0640@2|Bacteria,1R71B@1224|Proteobacteria,1S2D9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator, ArsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5,Rhodanese
TLS1_k127_1717821_10	1122602.ATXP01000005_gene2077	1.565e-29	121.0	COG3118@1|root,COG3118@2|Bacteria,2IQ9T@201174|Actinobacteria,1W9S8@1268|Micrococcaceae	201174|Actinobacteria	O	Belongs to the thioredoxin family	trxA	GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
TLS1_k127_1717821_16	1382356.JQMP01000004_gene221	1.017e-05	57.0	COG4283@1|root,COG4283@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1706)	M1-431	-	-	-	-	-	-	-	-	-	-	-	DUF1706
TLS1_k127_1717821_0	326427.Cagg_2545	4.078e-219	710.0	COG1884@1|root,COG1884@2|Bacteria,2G62T@200795|Chloroflexi,374XE@32061|Chloroflexia	32061|Chloroflexia	I	TIGRFAM methylmalonyl-CoA mutase, large subunit	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
TLS1_k127_1717821_15	1235794.C811_02330	5.981e-08	64.0	COG0484@1|root,COG0484@2|Bacteria,2HUXK@201174|Actinobacteria,4CVYI@84998|Coriobacteriia	84998|Coriobacteriia	O	DnaJ molecular chaperone homology domain	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ
TLS1_k127_1717821_11	640081.Dsui_1002	7.815e-26	121.0	COG1073@1|root,COG1073@2|Bacteria,1MY4C@1224|Proteobacteria,2WEH2@28216|Betaproteobacteria,2KUPJ@206389|Rhodocyclales	206389|Rhodocyclales	S	BAAT Acyl-CoA thioester hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
TLS1_k127_1717821_14	1121272.KB903249_gene2255	4.335e-09	68.0	COG0778@1|root,COG0778@2|Bacteria,2HG9I@201174|Actinobacteria,4DK68@85008|Micromonosporales	201174|Actinobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS1_k127_1808358_12	1137271.AZUM01000012_gene1932	4.092e-20	101.0	COG0438@1|root,COG0438@2|Bacteria,2GIVP@201174|Actinobacteria,4E16E@85010|Pseudonocardiales	201174|Actinobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS1_k127_1808358_8	324602.Caur_2823	3.131e-42	175.0	COG1470@1|root,COG1470@2|Bacteria,2G6XR@200795|Chloroflexi,375A0@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function (DUF3048) C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
TLS1_k127_1808358_5	926550.CLDAP_36230	1.523e-57	219.0	COG0110@1|root,COG0110@2|Bacteria,2G7B9@200795|Chloroflexi	200795|Chloroflexi	S	PFAM transferase hexapeptide repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
TLS1_k127_1808358_0	926550.CLDAP_36220	4.732e-107	366.0	COG0399@1|root,COG0399@2|Bacteria,2G5QG@200795|Chloroflexi	200795|Chloroflexi	E	aromatic amino acid beta-eliminating lyase threonine aldolase	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
TLS1_k127_1808358_3	326427.Cagg_0831	8.865e-64	247.0	COG0673@1|root,COG0673@2|Bacteria,2G6Y0@200795|Chloroflexi,376NR@32061|Chloroflexia	32061|Chloroflexia	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS1_k127_1808358_1	1382306.JNIM01000001_gene1459	9.956e-106	378.0	COG0677@1|root,COG0677@2|Bacteria,2G5PP@200795|Chloroflexi	200795|Chloroflexi	M	PFAM UDP-glucose GDP-mannose dehydrogenase	-	-	1.1.1.336	ko:K02472	ko00520,ko05111,map00520,map05111	-	R03317	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
TLS1_k127_1808358_2	326427.Cagg_1972	2.491e-85	296.0	COG0381@1|root,COG0381@2|Bacteria,2G7S6@200795|Chloroflexi,375NM@32061|Chloroflexia	32061|Chloroflexia	M	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	-	-	5.1.3.23	ko:K13019	ko00520,map00520	-	R09600	RC00290	ko00000,ko00001,ko01000,ko01005	-	-	-	Epimerase_2
TLS1_k127_1808358_10	1381123.AYOD01000011_gene2857	1.74e-33	150.0	COG0438@1|root,COG0438@2|Bacteria,1MYJ6@1224|Proteobacteria	1224|Proteobacteria	M	Glycosyl transferase group 1	wbmJ	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS1_k127_1808358_9	32057.KB217478_gene6652	6.007e-36	157.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS1_k127_1808358_14	888052.HMPREF9006_1956	8.816e-13	81.0	COG0438@1|root,COG0438@2|Bacteria,2HK62@201174|Actinobacteria,4D4QE@85005|Actinomycetales	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4
TLS1_k127_1808358_13	1415774.U728_641	2.218e-14	86.0	COG0110@1|root,COG0110@2|Bacteria,1TQEX@1239|Firmicutes,249KF@186801|Clostridia,36FMC@31979|Clostridiaceae	186801|Clostridia	S	maltose O-acetyltransferase	-	-	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Hexapep_2,Mac
TLS1_k127_1808358_6	589924.Ferp_1922	6.515e-55	204.0	COG2120@1|root,arCOG03460@2157|Archaea,2XVSC@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM LmbE family protein	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
TLS1_k127_1808358_15	1227487.C474_07822	3.826e-12	78.0	COG0438@1|root,arCOG01410@2157|Archaea,2XV5R@28890|Euryarchaeota,23USK@183963|Halobacteria	183963|Halobacteria	M	COG0438 Glycosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS1_k127_1808358_11	1380390.JIAT01000013_gene281	3.468e-28	132.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS1_k127_1808358_4	1193181.BN10_520059	3.432e-60	229.0	COG1134@1|root,COG1134@2|Bacteria,2GIVF@201174|Actinobacteria,4FGNF@85021|Intrasporangiaceae	201174|Actinobacteria	GM	ABC transporter	rfbB2	-	3.6.3.40	ko:K01990,ko:K09691,ko:K09693	ko02010,map02010	M00250,M00251,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.103,3.A.1.104	-	-	ABC_tran,Wzt_C
TLS1_k127_1808358_7	1297742.A176_02776	2.75e-43	169.0	COG1682@1|root,COG1682@2|Bacteria,1N0X3@1224|Proteobacteria,42SZT@68525|delta/epsilon subdivisions,2WPTX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	GM	Transport permease protein	-	-	-	ko:K09688,ko:K09690	ko02010,map02010	M00249,M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.101,3.A.1.103	-	-	ABC2_membrane
TLS1_k127_1808485_6	555079.Toce_0833	1.834e-15	83.0	COG1146@1|root,COG1146@2|Bacteria,1VETY@1239|Firmicutes,25ETJ@186801|Clostridia,42HK8@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S binding domain	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
TLS1_k127_1808485_3	1430440.MGMSRv2_0763	9.251e-60	223.0	COG1611@1|root,COG1611@2|Bacteria,1RD59@1224|Proteobacteria,2U5DP@28211|Alphaproteobacteria,2JSHV@204441|Rhodospirillales	204441|Rhodospirillales	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
TLS1_k127_1808485_5	1223545.GS4_20_01900	3.196e-44	180.0	COG0127@1|root,COG0127@2|Bacteria,2GM2B@201174|Actinobacteria,4GA3I@85026|Gordoniaceae	201174|Actinobacteria	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
TLS1_k127_1808485_1	1449044.JMLE01000005_gene578	2.126e-81	279.0	COG0689@1|root,COG0689@2|Bacteria,2GJFI@201174|Actinobacteria,1W7XR@1268|Micrococcaceae	201174|Actinobacteria	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
TLS1_k127_1808485_2	1128421.JAGA01000002_gene1825	8.481e-74	263.0	COG1694@1|root,COG3956@2|Bacteria,2NP9V@2323|unclassified Bacteria	2|Bacteria	E	MazG nucleotide pyrophosphohydrolase domain	mazG	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.66,3.6.1.9	ko:K02428,ko:K02499,ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R01855,R02100,R02720,R03004,R03036,R03531,R11323	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	iJN678.sll1005	MazG,TP_methylase
TLS1_k127_1808485_8	335283.Neut_1217	3.39e-09	70.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2VHHS@28216|Betaproteobacteria,372HQ@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3,SurA_N
TLS1_k127_1808485_4	1120948.KB903218_gene1773	9.119e-59	222.0	COG0438@1|root,COG0438@2|Bacteria,2GSQI@201174|Actinobacteria,4E1TK@85010|Pseudonocardiales	201174|Actinobacteria	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glycos_transf_1
TLS1_k127_1808485_0	710685.MycrhN_1278	1.634e-120	405.0	COG0677@1|root,COG0677@2|Bacteria,2GK5K@201174|Actinobacteria,232R6@1762|Mycobacteriaceae	201174|Actinobacteria	M	PFAM UDP-glucose GDP-mannose dehydrogenase family, NAD binding domain	wbpA	-	1.1.1.136,1.1.1.336	ko:K02472,ko:K13015	ko00520,ko05111,map00520,map05111	-	R00421,R03317	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
TLS1_k127_1808485_7	1283299.AUKG01000001_gene2240	1.441e-12	77.0	COG0297@1|root,COG0297@2|Bacteria,2I7AF@201174|Actinobacteria,4CQ0R@84995|Rubrobacteria	84995|Rubrobacteria	G	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
TLS1_k127_1843900_5	1366050.N234_07375	3.606e-39	151.0	COG2164@1|root,COG2164@2|Bacteria,1RCY5@1224|Proteobacteria,2VR3R@28216|Betaproteobacteria,1K5F0@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF3830)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3830
TLS1_k127_1843900_9	1385520.N802_12130	9.194e-19	93.0	COG2351@1|root,COG2351@2|Bacteria,2IQUN@201174|Actinobacteria,4FJ7N@85021|Intrasporangiaceae	201174|Actinobacteria	S	HIUase/Transthyretin family	uraH	-	3.5.2.17	ko:K07127	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R06601	RC03393	ko00000,ko00001,ko00002,ko01000,ko02000	9.B.35.1.2,9.B.35.2	-	-	Transthyretin
TLS1_k127_1843900_8	36080.S2IXP3	6.948e-25	110.0	2CI4P@1|root,2S48Z@2759|Eukaryota,3A1KV@33154|Opisthokonta,3Q1A9@4751|Fungi,1GUKU@112252|Fungi incertae sedis	4751|Fungi	S	OHCU decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	OHCU_decarbox
TLS1_k127_1843900_3	1068978.AMETH_1603	9.253e-75	261.0	COG3648@1|root,COG3648@2|Bacteria,2GK7W@201174|Actinobacteria,4DXWX@85010|Pseudonocardiales	201174|Actinobacteria	Q	Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin	uox	-	1.7.3.3	ko:K00365	ko00230,ko00232,ko01100,ko01120,map00230,map00232,map01100,map01120	M00546	R02106,R07981	RC02107,RC02551	ko00000,ko00001,ko00002,ko01000	-	-	-	Uricase
TLS1_k127_1843900_6	358396.C445_17049	6.473e-27	124.0	arCOG12670@1|root,arCOG12670@2157|Archaea,2XXAX@28890|Euryarchaeota,23VWQ@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_1843900_2	479432.Sros_3301	3.7e-101	360.0	COG1404@1|root,COG1404@2|Bacteria,2GJYH@201174|Actinobacteria,4EFW4@85012|Streptosporangiales	201174|Actinobacteria	O	Peptidase inhibitor I9	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I9,PKD,P_proprotein,Peptidase_S8
TLS1_k127_1843900_4	1122611.KB903974_gene2885	6.302e-63	228.0	COG1273@1|root,COG1273@2|Bacteria,2GJMU@201174|Actinobacteria,4EHIV@85012|Streptosporangiales	201174|Actinobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
TLS1_k127_1843900_7	1089546.AQUI01000002_gene894	4.36e-25	117.0	COG0745@1|root,COG0745@2|Bacteria	1089546.AQUI01000002_gene894|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_1843900_1	1048339.KB913029_gene1694	5.881e-116	401.0	COG0467@1|root,COG0467@2|Bacteria,2I58C@201174|Actinobacteria	201174|Actinobacteria	T	KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
TLS1_k127_1843900_0	743722.Sph21_2578	1.028e-155	524.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,4NESR@976|Bacteroidetes,1IQI9@117747|Sphingobacteriia	976|Bacteroidetes	L	DNA ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
TLS1_k127_1946662_0	219305.MCAG_03594	2.514e-233	731.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4D9YX@85008|Micromonosporales	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS1_k127_1946662_2	479434.Sthe_1007	7.762e-51	190.0	COG0500@1|root,COG2226@2|Bacteria,2G99K@200795|Chloroflexi	200795|Chloroflexi	H	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_1946662_1	479434.Sthe_1006	6.384e-52	203.0	COG0644@1|root,COG0644@2|Bacteria	2|Bacteria	C	geranylgeranyl reductase activity	fixC	-	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	DAO,FAD_binding_3,Trp_halogenase
TLS1_k127_2013408_1	479435.Kfla_0661	1.506e-84	290.0	COG1940@1|root,COG1940@2|Bacteria,2IBV8@201174|Actinobacteria	201174|Actinobacteria	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
TLS1_k127_2013408_2	1123322.KB904634_gene2415	2.857e-75	257.0	COG0279@1|root,COG0279@2|Bacteria,2GM2Q@201174|Actinobacteria	201174|Actinobacteria	G	phosphoheptose isomerase	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
TLS1_k127_2013408_0	1123322.KB904634_gene2414	2.035e-309	968.0	COG0383@1|root,COG0383@2|Bacteria,2GM02@201174|Actinobacteria	201174|Actinobacteria	G	PFAM Glycoside hydrolase, family 38	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
TLS1_k127_2055462_11	981369.JQMJ01000004_gene1339	6.648e-60	209.0	COG2303@1|root,COG2303@2|Bacteria,2GJAU@201174|Actinobacteria,2NGX8@228398|Streptacidiphilus	201174|Actinobacteria	E	GMC oxidoreductase	betA	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
TLS1_k127_2055462_12	313596.RB2501_12217	3.436e-44	164.0	COG0346@1|root,COG0346@2|Bacteria,4P85Q@976|Bacteroidetes	976|Bacteroidetes	C	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS1_k127_2055462_8	1385519.N801_07380	2.36e-84	302.0	COG4262@1|root,COG4262@2|Bacteria,2I372@201174|Actinobacteria,4FISH@85021|Intrasporangiaceae	201174|Actinobacteria	S	Spermidine synthase	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
TLS1_k127_2055462_13	1449976.KALB_3165	6.795e-43	166.0	COG1414@1|root,COG1414@2|Bacteria,2GM23@201174|Actinobacteria,4E0VJ@85010|Pseudonocardiales	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
TLS1_k127_2055462_5	1469245.JFBG01000006_gene1588	1.938e-112	368.0	COG5012@1|root,COG5012@2|Bacteria,1QDZ3@1224|Proteobacteria,1RYST@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
TLS1_k127_2055462_10	1380394.JADL01000010_gene4319	4.83e-69	244.0	28I8Y@1|root,2Z8BR@2|Bacteria,1MXN1@1224|Proteobacteria,2TRAQ@28211|Alphaproteobacteria,2JS8U@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF1638)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1638
TLS1_k127_2055462_14	998674.ATTE01000001_gene276	2.452e-20	102.0	2CDZD@1|root,32RYT@2|Bacteria,1N0AT@1224|Proteobacteria,1SSFV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Virulence factor	-	-	-	-	-	-	-	-	-	-	-	-	Virulence_fact
TLS1_k127_2055462_3	1380394.JADL01000010_gene4322	8.644e-131	423.0	COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2TSBY@28211|Alphaproteobacteria,2JPHI@204441|Rhodospirillales	204441|Rhodospirillales	E	CO dehydrogenase/acetyl-CoA synthase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Pterin_bind
TLS1_k127_2055462_0	1380391.JIAS01000001_gene2815	1.261e-271	854.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,2TUJB@28211|Alphaproteobacteria,2JQGJ@204441|Rhodospirillales	204441|Rhodospirillales	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
TLS1_k127_2055462_1	1380394.JADL01000010_gene4324	6.637e-241	754.0	COG5598@1|root,COG5598@2|Bacteria,1MWJN@1224|Proteobacteria,2TR0V@28211|Alphaproteobacteria,2JRHD@204441|Rhodospirillales	204441|Rhodospirillales	H	Trimethylamine methyltransferase (MTTB)	-	-	-	-	-	-	-	-	-	-	-	-	MTTB
TLS1_k127_2055462_9	1123023.JIAI01000001_gene6372	1.08e-73	262.0	COG0685@1|root,COG0685@2|Bacteria,2I92A@201174|Actinobacteria,4E35Z@85010|Pseudonocardiales	201174|Actinobacteria	E	Methylenetetrahydrofolate reductase	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
TLS1_k127_2055462_2	1380393.JHVP01000003_gene1188	5.358e-136	443.0	COG1473@1|root,COG1473@2|Bacteria,2GK05@201174|Actinobacteria,4EUKK@85013|Frankiales	201174|Actinobacteria	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
TLS1_k127_2055462_15	926554.KI912636_gene3085	1.588e-06	60.0	COG2318@1|root,COG2318@2|Bacteria,1WMX9@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS1_k127_2055462_7	1128421.JAGA01000002_gene1691	2.328e-100	334.0	COG3694@1|root,COG3694@2|Bacteria,2NQKI@2323|unclassified Bacteria	2|Bacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
TLS1_k127_2055462_6	1128421.JAGA01000002_gene1692	9.422e-110	375.0	COG4587@1|root,COG4587@2|Bacteria	2|Bacteria	S	transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
TLS1_k127_2055462_4	1128421.JAGA01000002_gene1693	6.426e-128	415.0	COG4586@1|root,COG4586@2|Bacteria,2NP49@2323|unclassified Bacteria	2|Bacteria	S	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS1_k127_2056035_3	469371.Tbis_1648	9.893e-07	57.0	COG2217@1|root,COG2846@1|root,COG2217@2|Bacteria,COG2846@2|Bacteria,2GIRF@201174|Actinobacteria,4E0TG@85010|Pseudonocardiales	201174|Actinobacteria	P	heavy metal translocating P-type ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hemerythrin,Hydrolase
TLS1_k127_2056035_2	526225.Gobs_0891	2.44e-07	63.0	2CHDY@1|root,34984@2|Bacteria,2GZFK@201174|Actinobacteria,4EWBW@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_2056035_0	1283299.AUKG01000001_gene2174	2.083e-110	387.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4CRHY@84995|Rubrobacteria	84995|Rubrobacteria	T	Diguanylate cyclase phosphodiesterase with PAS PAC	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
TLS1_k127_2056035_1	42256.RradSPS_0609	5.966e-40	159.0	COG0288@1|root,COG0288@2|Bacteria,2GM1M@201174|Actinobacteria,4CSPT@84995|Rubrobacteria	84995|Rubrobacteria	P	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
TLS1_k127_2061786_3	1370125.AUWT01000035_gene1427	5.67e-116	386.0	COG0515@1|root,COG0515@2|Bacteria,2I2F0@201174|Actinobacteria,235R0@1762|Mycobacteriaceae	201174|Actinobacteria	KLT	PFAM Lipopolysaccharide kinase (Kdo WaaP) family	-	-	-	-	-	-	-	-	-	-	-	-	DUF4032,Kdo
TLS1_k127_2061786_16	1453496.AT03_03605	1.304e-06	60.0	COG0454@1|root,COG0456@2|Bacteria,1QEZN@1224|Proteobacteria,1S4IF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role	phnO	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006793,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019634,GO:0019637,GO:0033051,GO:0044237,GO:0044424,GO:0044464,GO:0071704,GO:1901564	-	ko:K09994	ko00440,map00440	-	R11479	RC00096	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1
TLS1_k127_2061786_14	436229.JOEH01000052_gene6303	1.381e-12	80.0	COG0454@1|root,COG0456@2|Bacteria,2GKQU@201174|Actinobacteria,2NF7A@228398|Streptacidiphilus	201174|Actinobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_6
TLS1_k127_2061786_13	298654.FraEuI1c_2647	3.006e-13	76.0	COG3794@1|root,COG3794@2|Bacteria,2HPHA@201174|Actinobacteria,4EWSY@85013|Frankiales	201174|Actinobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_2061786_10	1137271.AZUM01000001_gene1415	9.574e-26	121.0	COG2519@1|root,COG2519@2|Bacteria,2GMKZ@201174|Actinobacteria,4EF77@85010|Pseudonocardiales	201174|Actinobacteria	J	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS1_k127_2061786_8	1128421.JAGA01000002_gene1044	5.111e-35	142.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS1_k127_2061786_6	1382306.JNIM01000001_gene1969	2.19e-69	244.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	ogt	-	2.1.1.63,3.2.2.21	ko:K00567,ko:K13529,ko:K15051	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,AraC_binding,DNA_binding_1,Endonuclea_NS_2,HTH_18
TLS1_k127_2061786_5	356851.JOAN01000004_gene1110	1.325e-69	248.0	COG0697@1|root,COG0697@2|Bacteria,2I91Y@201174|Actinobacteria,4DF2R@85008|Micromonosporales	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS1_k127_2061786_0	1382356.JQMP01000003_gene2113	1.782e-175	557.0	COG1960@1|root,COG1960@2|Bacteria,2G65J@200795|Chloroflexi,27Y45@189775|Thermomicrobia	189775|Thermomicrobia	C	Acyl- CoA dehydrogenase type 2 domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS1_k127_2061786_4	338966.Ppro_0566	8.652e-111	393.0	COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,42MB7@68525|delta/epsilon subdivisions,2WJVU@28221|Deltaproteobacteria,43TEH@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS1_k127_2061786_15	311424.DhcVS_1131	1.081e-07	63.0	COG0789@1|root,COG0789@2|Bacteria,2G9W3@200795|Chloroflexi,34DHG@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
TLS1_k127_2061786_1	1131462.DCF50_p77	6.586e-119	396.0	COG1055@1|root,COG1055@2|Bacteria,1TPNN@1239|Firmicutes,2494X@186801|Clostridia,261AN@186807|Peptococcaceae	186801|Clostridia	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
TLS1_k127_2061786_11	479434.Sthe_1368	2.726e-24	108.0	2DPD4@1|root,331JQ@2|Bacteria,2G9MC@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF3224)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3224
TLS1_k127_2061786_9	1463917.JODC01000003_gene5844	1.836e-27	120.0	COG0346@1|root,COG0346@2|Bacteria,2IRQX@201174|Actinobacteria	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS1_k127_2061786_7	1123392.AQWL01000002_gene1991	1.812e-46	177.0	COG1814@1|root,COG1814@2|Bacteria,1MUZE@1224|Proteobacteria,2VJ27@28216|Betaproteobacteria,1KSVB@119069|Hydrogenophilales	119069|Hydrogenophilales	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
TLS1_k127_2061786_12	713586.KB900536_gene955	9.872e-16	88.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	ko:K06149	-	-	-	-	ko00000	-	-	-	Usp
TLS1_k127_2061786_2	1121272.KB903290_gene4678	9.979e-119	392.0	2C1EG@1|root,2Z7MZ@2|Bacteria,2GK4W@201174|Actinobacteria,4DHRJ@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_2076216_2	644966.Tmar_1212	2.393e-10	72.0	COG4961@1|root,COG4961@2|Bacteria,1VFNR@1239|Firmicutes,24R06@186801|Clostridia,3WDPM@538999|Clostridiales incertae sedis	186801|Clostridia	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
TLS1_k127_2076216_1	269797.Mbar_A1800	1.382e-17	94.0	COG1520@1|root,COG3291@1|root,arCOG02550@1|root,arCOG03991@1|root,arCOG02482@2157|Archaea,arCOG02510@2157|Archaea,arCOG02550@2157|Archaea,arCOG03991@2157|Archaea,2XUI1@28890|Euryarchaeota,2NBKW@224756|Methanomicrobia	2157|Archaea	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,CBM_6,DUF3344,NosD,PKD,PQQ_2,PQQ_3,Pkinase
TLS1_k127_2076216_3	555088.DealDRAFT_0813	0.000423	53.0	COG4655@1|root,COG4655@2|Bacteria,1U3VY@1239|Firmicutes,24RIV@186801|Clostridia	186801|Clostridia	S	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
TLS1_k127_2076216_4	861299.J421_6027	0.000985	52.0	2EB5B@1|root,33561@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_2076216_0	485913.Krac_2641	2.455e-145	471.0	COG1233@1|root,COG1233@2|Bacteria,2G60T@200795|Chloroflexi	200795|Chloroflexi	Q	NAD(P)-binding Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
TLS1_k127_2108450_3	1499683.CCFF01000014_gene4127	1.049e-64	230.0	COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,248I8@186801|Clostridia,36E2S@31979|Clostridiaceae	186801|Clostridia	E	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
TLS1_k127_2108450_5	589924.Ferp_1104	1.915e-59	214.0	COG0563@1|root,arCOG01046@2157|Archaea,2XTRG@28890|Euryarchaeota,246UX@183980|Archaeoglobi	183980|Archaeoglobi	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
TLS1_k127_2108450_0	309801.trd_0965	2.147e-128	422.0	COG0201@1|root,COG0201@2|Bacteria,2G5X4@200795|Chloroflexi,27XI1@189775|Thermomicrobia	189775|Thermomicrobia	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
TLS1_k127_2108450_7	986075.CathTA2_2514	3.118e-35	149.0	COG0200@1|root,COG0200@2|Bacteria,1V3KE@1239|Firmicutes,4HFPW@91061|Bacilli	91061|Bacilli	J	binds to the 23S rRNA	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
TLS1_k127_2108450_12	397290.C810_00314	8.05e-16	80.0	COG1841@1|root,COG1841@2|Bacteria,1VEG4@1239|Firmicutes,24QKC@186801|Clostridia,27PMP@186928|unclassified Lachnospiraceae	186801|Clostridia	J	Ribosomal protein L30p/L7e	rpmD	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
TLS1_k127_2108450_4	555088.DealDRAFT_1506	8.115e-61	220.0	COG0098@1|root,COG0098@2|Bacteria,1V1B1@1239|Firmicutes,24G5D@186801|Clostridia,42JVW@68298|Syntrophomonadaceae	186801|Clostridia	J	Belongs to the universal ribosomal protein uS5 family	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
TLS1_k127_2108450_8	525909.Afer_0414	7.92e-35	139.0	COG0256@1|root,COG0256@2|Bacteria,2IKTX@201174|Actinobacteria,4CNBZ@84992|Acidimicrobiia	84992|Acidimicrobiia	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
TLS1_k127_2108450_2	479434.Sthe_1051	1.602e-68	237.0	COG0097@1|root,COG0097@2|Bacteria,2G6HZ@200795|Chloroflexi,27Y65@189775|Thermomicrobia	189775|Thermomicrobia	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
TLS1_k127_2108450_6	340099.Teth39_0388	4.745e-45	169.0	COG0096@1|root,COG0096@2|Bacteria,1V3KK@1239|Firmicutes,24HCP@186801|Clostridia,42G9H@68295|Thermoanaerobacterales	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
TLS1_k127_2108450_11	335543.Sfum_1568	8.676e-22	95.0	COG0199@1|root,COG0199@2|Bacteria,1PDMJ@1224|Proteobacteria,42VCE@68525|delta/epsilon subdivisions,2WR7W@28221|Deltaproteobacteria,2MS3E@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
TLS1_k127_2108450_1	525904.Tter_0727	1.142e-76	268.0	COG0094@1|root,COG0094@2|Bacteria,2NP65@2323|unclassified Bacteria	2|Bacteria	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
TLS1_k127_2108450_10	697329.Rumal_0047	1.664e-22	104.0	COG0198@1|root,COG0198@2|Bacteria,1V9ZQ@1239|Firmicutes,24MY0@186801|Clostridia,3WJBH@541000|Ruminococcaceae	186801|Clostridia	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
TLS1_k127_2108450_9	747365.Thena_0514	2.521e-24	102.0	COG0093@1|root,COG0093@2|Bacteria,1V3N0@1239|Firmicutes,24H98@186801|Clostridia,42GCY@68295|Thermoanaerobacterales	186801|Clostridia	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
TLS1_k127_2161900_3	272943.RSP_4030	7.881e-58	212.0	COG3684@1|root,COG3684@2|Bacteria,1QZI3@1224|Proteobacteria,2U07T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	DeoC/LacD family aldolase	MA20_09915	-	4.1.2.40,4.1.2.57	ko:K01635,ko:K01671	ko00052,ko01100,ko02024,map00052,map01100,map02024	-	R01069,R10760	RC00438,RC00439	ko00000,ko00001,ko01000	-	-	-	DeoC
TLS1_k127_2161900_2	525904.Tter_2130	1.085e-78	280.0	COG2971@1|root,COG2971@2|Bacteria	2|Bacteria	G	N-acetylglucosamine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
TLS1_k127_2161900_1	1382306.JNIM01000001_gene1937	4.663e-170	544.0	COG1486@1|root,COG1486@2|Bacteria,2G6IX@200795|Chloroflexi	200795|Chloroflexi	G	Family 4 glycosyl hydrolase	-	-	3.2.1.86	ko:K01222	ko00010,ko00500,map00010,map00500	-	R00839,R05133,R05134	RC00049,RC00171,RC00714	ko00000,ko00001,ko01000	-	GT4	-	Glyco_hydro_4,Glyco_hydro_4C
TLS1_k127_2161900_0	357808.RoseRS_2452	6.412e-213	677.0	COG0366@1|root,COG4733@1|root,COG0366@2|Bacteria,COG4733@2|Bacteria,2G7WY@200795|Chloroflexi,37544@32061|Chloroflexia	32061|Chloroflexia	G	Belongs to the glycosyl hydrolase 13 family	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,CBM_20,fn3
TLS1_k127_2164188_0	463191.SSEG_05612	4.864e-238	746.0	COG2303@1|root,COG2303@2|Bacteria,2GJAU@201174|Actinobacteria	201174|Actinobacteria	E	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate	betA	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
TLS1_k127_2164188_4	42256.RradSPS_0281	1.591e-06	61.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
TLS1_k127_2164188_2	304371.MCP_2041	5.377e-73	267.0	COG1131@1|root,arCOG00194@2157|Archaea	2157|Archaea	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS1_k127_2164188_1	469383.Cwoe_3718	4.314e-99	347.0	COG4585@1|root,COG4585@2|Bacteria,2GIXR@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
TLS1_k127_2164188_3	321846.PS417_21845	4.15e-19	93.0	COG4420@1|root,COG4420@2|Bacteria,1RFFX@1224|Proteobacteria,1S50Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003
TLS1_k127_2201259_2	5127.CCT75940	0.0001466	52.0	2E1K8@1|root,2RR6V@2759|Eukaryota,38UYY@33154|Opisthokonta,3PWJ1@4751|Fungi,3RFI3@4890|Ascomycota,21ICS@147550|Sordariomycetes,3TRSS@5125|Hypocreales,1FYGA@110618|Nectriaceae	4751|Fungi	S	YCII-related domain	-	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
TLS1_k127_2201259_1	1472716.KBK24_0112515	5.547e-55	221.0	COG2211@1|root,COG2211@2|Bacteria,1R8C2@1224|Proteobacteria	1224|Proteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS1_k127_2201259_0	649747.HMPREF0083_05891	1.989e-120	407.0	COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,4H9VR@91061|Bacilli,26QWN@186822|Paenibacillaceae	91061|Bacilli	E	acetolactate synthase	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS1_k127_2205876_4	439235.Dalk_2643	5.906e-05	52.0	COG3884@1|root,COG3884@2|Bacteria,1RK7J@1224|Proteobacteria,42SWW@68525|delta/epsilon subdivisions,2WPK8@28221|Deltaproteobacteria,2MK3P@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Acyl-ACP thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-ACP_TE
TLS1_k127_2205876_1	1089545.KB913037_gene7000	5.442e-161	526.0	COG1228@1|root,COG1228@2|Bacteria,2GMUS@201174|Actinobacteria,4E1ST@85010|Pseudonocardiales	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS1_k127_2205876_2	1381751.JAJB01000001_gene2879	7.407e-107	356.0	COG3214@1|root,COG3214@2|Bacteria,2HPNB@201174|Actinobacteria,4FB40@85019|Brevibacteriaceae	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
TLS1_k127_2205876_3	1385520.N802_06030	9.629e-43	172.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	ampC	-	3.5.2.6	ko:K01467,ko:K06160	ko01501,ko02010,ko02020,map01501,map02010,map02020	M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.113.2	-	-	Beta-lactamase,DUF3471
TLS1_k127_2205876_0	324602.Caur_0705	4.798e-260	831.0	COG0366@1|root,COG4733@1|root,COG0366@2|Bacteria,COG4733@2|Bacteria,2G7WY@200795|Chloroflexi,37544@32061|Chloroflexia	32061|Chloroflexia	G	Belongs to the glycosyl hydrolase 13 family	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,CBM_20,fn3
TLS1_k127_2218053_2	1297570.MESS4_560033	7.55e-160	519.0	COG0006@1|root,COG0006@2|Bacteria,1N8DW@1224|Proteobacteria,2U2SF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Xaa-Pro aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
TLS1_k127_2218053_1	384765.SIAM614_02056	7.786e-170	557.0	COG3118@1|root,COG3118@2|Bacteria,1PQ8G@1224|Proteobacteria,2U0PC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
TLS1_k127_2218053_0	243233.MCA2161	2.421e-215	688.0	COG3206@1|root,COG3206@2|Bacteria,1QX0J@1224|Proteobacteria,1RZ5A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	protein involved in exopolysaccharide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_2218053_3	643562.Daes_2587	8.187e-95	332.0	COG0673@1|root,COG0673@2|Bacteria,1MZIG@1224|Proteobacteria,43E7I@68525|delta/epsilon subdivisions,2X39F@28221|Deltaproteobacteria,2M8XH@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM oxidoreductase domain protein	-	-	1.1.1.384	ko:K13327	ko00523,ko01130,map00523,map01130	M00801,M00802	R05526	RC00897	ko00000,ko00001,ko00002,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS1_k127_2218053_5	266117.Rxyl_3000	3.195e-64	241.0	COG4221@1|root,COG4221@2|Bacteria,2GP05@201174|Actinobacteria,4CSD7@84995|Rubrobacteria	84995|Rubrobacteria	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS1_k127_2218053_4	391037.Sare_4239	5.822e-70	247.0	COG1940@1|root,COG1940@2|Bacteria,2GPEI@201174|Actinobacteria,4DAH2@85008|Micromonosporales	201174|Actinobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	ROK
TLS1_k127_2220445_8	1122611.KB903948_gene6655	9.611e-59	220.0	COG1472@1|root,COG1472@2|Bacteria,2GM43@201174|Actinobacteria,4EFRX@85012|Streptosporangiales	201174|Actinobacteria	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
TLS1_k127_2220445_4	324602.Caur_1108	2.256e-101	351.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	yurM1	-	-	ko:K17246	ko02010,map02010	M00601	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.40	-	-	BPD_transp_1
TLS1_k127_2220445_2	324602.Caur_1107	7.201e-114	375.0	COG1175@1|root,COG1175@2|Bacteria,2G8BY@200795|Chloroflexi,3773P@32061|Chloroflexia	2|Bacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	lacF	-	-	ko:K02025,ko:K05814,ko:K10118,ko:K10233,ko:K15771,ko:K17245	ko02010,map02010	M00196,M00198,M00201,M00207,M00491,M00601	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.28,3.A.1.1.3,3.A.1.1.32,3.A.1.1.40,3.A.1.1.8	-	-	BPD_transp_1
TLS1_k127_2220445_1	324602.Caur_1106	4.602e-129	443.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	srrA1	-	-	ko:K02027,ko:K17244	ko02010,map02010	M00207,M00601	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.40	-	-	SBP_bac_1,SBP_bac_8
TLS1_k127_2220445_6	926550.CLDAP_35960	9.998e-61	231.0	COG1940@1|root,COG1940@2|Bacteria,2G6H1@200795|Chloroflexi	200795|Chloroflexi	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
TLS1_k127_2220445_5	926569.ANT_08120	2.502e-91	315.0	COG1940@1|root,COG1940@2|Bacteria,2G7R1@200795|Chloroflexi	200795|Chloroflexi	K	PFAM ROK family protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,ROK
TLS1_k127_2220445_7	405948.SACE_1590	1.391e-59	228.0	COG2971@1|root,COG2971@2|Bacteria,2GKNB@201174|Actinobacteria,4E0TB@85010|Pseudonocardiales	201174|Actinobacteria	G	BadF/BadG/BcrA/BcrD ATPase family	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
TLS1_k127_2220445_9	930171.Asphe3_20830	9.863e-27	126.0	COG0726@1|root,COG0726@2|Bacteria,2HEQK@201174|Actinobacteria,1WBMB@1268|Micrococcaceae	201174|Actinobacteria	G	Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
TLS1_k127_2220445_0	926550.CLDAP_13290	6.711e-130	426.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS1_k127_2220445_3	926550.CLDAP_13300	3.595e-106	352.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	ko:K02025,ko:K05814,ko:K10118,ko:K10237,ko:K10241,ko:K15771,ko:K17235,ko:K17242,ko:K17316	ko02010,map02010	M00196,M00198,M00204,M00206,M00207,M00491,M00600,M00602,M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.17,3.A.1.1.2,3.A.1.1.23,3.A.1.1.24,3.A.1.1.28,3.A.1.1.3,3.A.1.1.30,3.A.1.1.34,3.A.1.1.39	-	-	BPD_transp_1
TLS1_k127_2252024_13	1345695.CLSA_c42360	1.078e-53	199.0	COG0836@1|root,COG0836@2|Bacteria,1TPC9@1239|Firmicutes,24908@186801|Clostridia,36DFS@31979|Clostridiaceae	186801|Clostridia	M	mannose-1-phosphate guanylyltransferase	manC	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
TLS1_k127_2252024_16	745776.DGo_CA2401	5.287e-38	151.0	COG0662@1|root,COG1396@1|root,COG0662@2|Bacteria,COG1396@2|Bacteria,1WMMD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	Cro/C1-type HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_31
TLS1_k127_2252024_7	266117.Rxyl_2912	2.536e-110	370.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4CRCY@84995|Rubrobacteria	84995|Rubrobacteria	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	3.6.3.31	ko:K11072	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1	-	-	ABC_tran,TOBE_2
TLS1_k127_2252024_12	1304880.JAGB01000003_gene995	7.707e-65	241.0	COG0687@1|root,COG0687@2|Bacteria,1TPY1@1239|Firmicutes,2483K@186801|Clostridia	186801|Clostridia	P	ABC transporter, solute-binding protein	potD	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1,SBP_bac_6,SBP_bac_8
TLS1_k127_2252024_9	1245471.PCA10_08520	8.674e-84	287.0	COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,1RNNZ@1236|Gammaproteobacteria,1YF36@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
TLS1_k127_2252024_10	1380391.JIAS01000019_gene1295	5.039e-77	269.0	COG1177@1|root,COG1177@2|Bacteria,1MVC5@1224|Proteobacteria,2TRRJ@28211|Alphaproteobacteria,2JQ7X@204441|Rhodospirillales	204441|Rhodospirillales	E	COG1177 ABC-type spermidine putrescine transport system, permease component II	-	-	-	ko:K11070	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
TLS1_k127_2252024_1	697284.ERIC2_c00860	4.162e-171	548.0	COG0192@1|root,COG0192@2|Bacteria,1TPCV@1239|Firmicutes,4HB33@91061|Bacilli,26QFD@186822|Paenibacillaceae	91061|Bacilli	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
TLS1_k127_2252024_4	1048339.KB913029_gene3858	9.927e-136	444.0	COG3844@1|root,COG3844@2|Bacteria,2GMJQ@201174|Actinobacteria,4ERDH@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively	kynU	-	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
TLS1_k127_2252024_14	1329516.JPST01000012_gene28	5.282e-40	171.0	COG5017@1|root,COG5017@2|Bacteria,1V2RT@1239|Firmicutes,4I1HA@91061|Bacilli,27CY8@186824|Thermoactinomycetaceae	91061|Bacilli	S	D-glucuronyl C5-epimerase C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	C5-epim_C
TLS1_k127_2252024_3	1519464.HY22_00855	7.418e-137	455.0	COG0025@1|root,COG0025@2|Bacteria,1FFIB@1090|Chlorobi	1090|Chlorobi	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
TLS1_k127_2252024_0	42256.RradSPS_0553	3.743e-196	659.0	COG1506@1|root,COG1506@2|Bacteria,2GNG5@201174|Actinobacteria	201174|Actinobacteria	E	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
TLS1_k127_2252024_2	326424.FRAAL1283	2.4e-165	546.0	COG0499@1|root,COG0499@2|Bacteria,2GK2Q@201174|Actinobacteria	201174|Actinobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
TLS1_k127_2252024_17	68260.JOAY01000024_gene1073	2.177e-20	106.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,FR47
TLS1_k127_2252024_15	1056816.JAFQ01000004_gene5621	9.313e-39	166.0	COG0182@1|root,COG0235@1|root,COG0182@2|Bacteria,COG0235@2|Bacteria,2GJJA@201174|Actinobacteria,4FWRR@85025|Nocardiaceae	201174|Actinobacteria	GJ	Belongs to the EIF-2B alpha beta delta subunits family. MtnA subfamily	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II,IF-2B
TLS1_k127_2252024_11	525904.Tter_0792	1.914e-66	232.0	COG0503@1|root,COG0503@2|Bacteria,2NPGX@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	PRTase_2,Pribosyltran,TRSP
TLS1_k127_2252024_6	266117.Rxyl_1175	1.739e-129	424.0	COG1840@1|root,COG1840@2|Bacteria,2HRRI@201174|Actinobacteria,4CTU6@84995|Rubrobacteria	84995|Rubrobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
TLS1_k127_2252024_5	326427.Cagg_2417	1.205e-131	456.0	COG1178@1|root,COG1178@2|Bacteria,2G5Q0@200795|Chloroflexi,375FG@32061|Chloroflexia	32061|Chloroflexia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
TLS1_k127_2252024_8	326427.Cagg_2622	9.729e-88	323.0	COG3842@1|root,COG3842@2|Bacteria,2G5P8@200795|Chloroflexi,37556@32061|Chloroflexia	32061|Chloroflexia	P	Belongs to the ABC transporter superfamily	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
TLS1_k127_2277183_0	479434.Sthe_1716	8.982e-183	577.0	COG1260@1|root,COG1260@2|Bacteria,2G5YH@200795|Chloroflexi,27Y0U@189775|Thermomicrobia	189775|Thermomicrobia	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
TLS1_k127_2277183_5	593907.Celgi_1572	3.814e-17	93.0	COG1560@1|root,COG1560@2|Bacteria,2GM7B@201174|Actinobacteria,4F2A6@85016|Cellulomonadaceae	201174|Actinobacteria	M	PFAM lipid A biosynthesis acyltransferase	htrB	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.3.1.265	ko:K22311	-	-	-	-	ko00000,ko01000	-	-	-	Lip_A_acyltrans
TLS1_k127_2277183_4	1246448.ANAZ01000004_gene4857	1.729e-17	97.0	COG1560@1|root,COG1560@2|Bacteria,2GM7B@201174|Actinobacteria,4EHU2@85012|Streptosporangiales	201174|Actinobacteria	M	Bacterial lipid A biosynthesis acyltransferase	htrB	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.3.1.265	ko:K22311	-	-	-	-	ko00000,ko01000	-	-	-	Lip_A_acyltrans
TLS1_k127_2277183_2	1382306.JNIM01000001_gene4122	2.623e-36	158.0	COG0613@1|root,COG0613@2|Bacteria,2G74N@200795|Chloroflexi	200795|Chloroflexi	S	SMART phosphoesterase PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP,PHP_C
TLS1_k127_2277183_1	311424.DhcVS_851	1.284e-82	294.0	COG0438@1|root,COG0438@2|Bacteria,2G61C@200795|Chloroflexi,34CIQ@301297|Dehalococcoidia	301297|Dehalococcoidia	M	Glycosyl transferases group 1	-	-	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
TLS1_k127_2277183_3	44251.PDUR_03425	5.514e-31	144.0	COG4346@1|root,COG5650@1|root,COG4346@2|Bacteria,COG5650@2|Bacteria,1TSHX@1239|Firmicutes,4HNW3@91061|Bacilli,27548@186822|Paenibacillaceae	91061|Bacilli	O	C-terminal four TMM region of protein-O-mannosyltransferase	-	-	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	GT87,PMT_2,PMT_4TMC
TLS1_k127_230773_6	290397.Adeh_1249	7.586e-93	311.0	COG1816@1|root,COG1816@2|Bacteria,1MWBV@1224|Proteobacteria	1224|Proteobacteria	F	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism	add	GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009156,GO:0009161,GO:0009163,GO:0009164,GO:0009165,GO:0009167,GO:0009168,GO:0009987,GO:0015949,GO:0015950,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0032261,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0043173,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	iSFV_1184.SFV_1640,iSF_1195.SF1648,iSFxv_1172.SFxv_1849,iS_1188.S1780	A_deaminase
TLS1_k127_230773_8	867903.ThesuDRAFT_02358	6.977e-76	265.0	COG1533@1|root,COG1533@2|Bacteria,1TSS2@1239|Firmicutes,248SB@186801|Clostridia,3WDHP@538999|Clostridiales incertae sedis	186801|Clostridia	L	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS1_k127_230773_0	1122182.KB903814_gene3209	0.0	1236.0	COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria,4D9FU@85008|Micromonosporales	201174|Actinobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,Inhibitor_I9,PA,Peptidase_S8
TLS1_k127_230773_5	525904.Tter_0096	1.562e-112	372.0	COG0320@1|root,COG0320@2|Bacteria,2NNPI@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
TLS1_k127_230773_12	525904.Tter_2599	1.057e-48	189.0	COG0451@1|root,COG0451@2|Bacteria,2NPZU@2323|unclassified Bacteria	2|Bacteria	M	Male sterility protein	-	-	1.1.1.219,5.1.3.26	ko:K00091,ko:K19997	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
TLS1_k127_230773_7	292459.STH2160	3.109e-92	323.0	COG0508@1|root,COG0508@2|Bacteria,1TR5N@1239|Firmicutes,247Q5@186801|Clostridia	186801|Clostridia	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	-	-	2.3.1.12,2.3.1.168	ko:K00627,ko:K09699	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200	M00036,M00307	R00209,R02569,R02662,R03174,R04097,R10998	RC00004,RC02727,RC02742,RC02857,RC02870	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,CMD,E3_binding
TLS1_k127_230773_10	1120950.KB892789_gene77	1.064e-65	255.0	COG3214@1|root,COG3214@2|Bacteria,2GK0T@201174|Actinobacteria	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
TLS1_k127_230773_16	1254432.SCE1572_07585	2.035e-12	70.0	2E363@1|root,32Y5Y@2|Bacteria,1P1I8@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_230773_3	1157490.EL26_15655	1.116e-131	444.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,4HAP6@91061|Bacilli,2788A@186823|Alicyclobacillaceae	91061|Bacilli	C	Transketolase, pyrimidine binding domain	dxpS	-	1.2.4.4	ko:K00167	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
TLS1_k127_230773_4	479434.Sthe_3477	1.194e-114	381.0	COG1071@1|root,COG1071@2|Bacteria,2GAC3@200795|Chloroflexi,27Z5H@189775|Thermomicrobia	189775|Thermomicrobia	C	Dehydrogenase E1 component	-	-	1.2.4.4	ko:K00166	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
TLS1_k127_230773_2	1305836.AXVE01000003_gene2616	3.569e-140	460.0	COG1249@1|root,COG1249@2|Bacteria,1TP1W@1239|Firmicutes,4H9Z5@91061|Bacilli,26EJ1@186818|Planococcaceae	91061|Bacilli	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	bfmBC	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS1_k127_230773_14	383372.Rcas_3560	9.714e-30	128.0	COG1278@1|root,COG1278@2|Bacteria,2G79W@200795|Chloroflexi,377DW@32061|Chloroflexia	32061|Chloroflexia	K	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
TLS1_k127_230773_13	444157.Tneu_1126	7.287e-32	135.0	COG0063@1|root,arCOG00018@2157|Archaea,2XPXN@28889|Crenarchaeota	28889|Crenarchaeota	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
TLS1_k127_230773_11	1128421.JAGA01000002_gene614	5.076e-57	216.0	COG1194@1|root,COG1194@2|Bacteria,2NPAU@2323|unclassified Bacteria	2|Bacteria	L	endonuclease III	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
TLS1_k127_230773_1	469383.Cwoe_1552	3.941e-174	559.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4CPEC@84995|Rubrobacteria	84995|Rubrobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.8	ko:K00130	ko00260,ko01100,map00260,map01100	M00555	R02565,R02566	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS1_k127_230773_15	33876.JNXY01000007_gene8277	2.399e-25	119.0	COG0619@1|root,COG0619@2|Bacteria,2IDC9@201174|Actinobacteria,4D9JP@85008|Micromonosporales	201174|Actinobacteria	P	cobalt transport	ykoC	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
TLS1_k127_230773_9	446470.Snas_2045	7.098e-72	257.0	COG1122@1|root,COG1122@2|Bacteria,2GJ0M@201174|Actinobacteria	201174|Actinobacteria	P	part of an ABC transporter complex. Responsible for energy coupling to the transport system	ykoD	-	-	ko:K16785,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran,CbiQ
TLS1_k127_2328392_0	671143.DAMO_2896	3.103e-158	519.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2NNZG@2323|unclassified Bacteria	2|Bacteria	L	UvrD/REP helicase N-terminal domain	-	-	3.6.4.12	ko:K03657,ko:K07465	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
TLS1_k127_2328392_2	401526.TcarDRAFT_0901	1.775e-24	110.0	COG1196@1|root,COG1196@2|Bacteria,1VAV4@1239|Firmicutes,4H4PK@909932|Negativicutes	909932|Negativicutes	D	Protein of unknown function (DUF4446)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4446
TLS1_k127_2328392_1	479434.Sthe_0425	4.952e-131	442.0	COG2256@1|root,COG2256@2|Bacteria,2G5JC@200795|Chloroflexi,27XS9@189775|Thermomicrobia	189775|Thermomicrobia	L	MgsA AAA+ ATPase C terminal	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA_assoc_2,MgsA_C,RuvB_N
TLS1_k127_2328392_3	661478.OP10G_0618	6.343e-19	87.0	COG2242@1|root,COG2242@2|Bacteria	2|Bacteria	H	protein methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
TLS1_k127_2362304_14	479435.Kfla_2975	4.271e-48	179.0	COG0596@1|root,COG0596@2|Bacteria,2GMYM@201174|Actinobacteria,4DTGY@85009|Propionibacteriales	201174|Actinobacteria	S	TAP-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
TLS1_k127_2362304_15	1122223.KB890696_gene196	3.892e-44	167.0	COG1309@1|root,COG1309@2|Bacteria,1WI7P@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_4,TetR_C_5,TetR_N
TLS1_k127_2362304_2	869210.Marky_1366	3.429e-131	430.0	COG3396@1|root,COG3396@2|Bacteria,1WI17@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	TIGRFAM phenylacetate-CoA oxygenase, PaaG subunit	paaA	-	1.14.13.149	ko:K02609	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
TLS1_k127_2362304_24	869210.Marky_1367	2.804e-19	93.0	COG3460@1|root,COG3460@2|Bacteria	2|Bacteria	Q	phenylacetate catabolic process	paaB	-	-	ko:K02610	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	PaaB
TLS1_k127_2362304_12	479434.Sthe_2569	5.549e-54	207.0	COG3396@1|root,COG3396@2|Bacteria,2G9KQ@200795|Chloroflexi	200795|Chloroflexi	S	PFAM phenylacetic acid catabolic family protein	-	-	1.14.13.149	ko:K02611	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
TLS1_k127_2362304_16	1051632.TPY_3279	6.884e-41	159.0	COG2151@1|root,COG2151@2|Bacteria,1V3QG@1239|Firmicutes	1239|Firmicutes	S	Phenylacetate-CoA oxygenase	paaD	-	-	ko:K02612	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FeS_assembly_P
TLS1_k127_2362304_7	861299.J421_3710	7.025e-74	265.0	COG1250@1|root,COG1250@2|Bacteria,1ZSSA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
TLS1_k127_2362304_0	1157490.EL26_23155	7.484e-171	546.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,4H9RJ@91061|Bacilli,277YV@186823|Alicyclobacillaceae	91061|Bacilli	I	Belongs to the thiolase family	pcaF	-	2.3.1.174,2.3.1.223,2.3.1.9	ko:K00626,ko:K02615	ko00071,ko00072,ko00280,ko00310,ko00360,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00360,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R00829,R01177,R09839	RC00004,RC00326,RC03003	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS1_k127_2362304_20	262724.TT_C1272	7.057e-32	132.0	COG0316@1|root,COG0316@2|Bacteria,1WKA9@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Belongs to the HesB IscA family	hesB	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
TLS1_k127_2362304_17	33876.JNXY01000044_gene1874	1.035e-35	149.0	COG2802@1|root,COG2802@2|Bacteria,2GNWA@201174|Actinobacteria,4DBBD@85008|Micromonosporales	201174|Actinobacteria	S	PFAM peptidase S16 lon domain protein	-	-	3.4.21.53	ko:K01338,ko:K07157	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
TLS1_k127_2362304_4	685727.REQ_25430	6.248e-99	341.0	COG3384@1|root,COG3384@2|Bacteria,2GKTV@201174|Actinobacteria,4FUIQ@85025|Nocardiaceae	201174|Actinobacteria	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
TLS1_k127_2362304_21	1235279.C772_00103	3.301e-25	113.0	COG1396@1|root,COG1917@1|root,COG1396@2|Bacteria,COG1917@2|Bacteria,1V2FR@1239|Firmicutes,4HGV3@91061|Bacilli,26FNK@186818|Planococcaceae	91061|Bacilli	K	Cupin domain	puuR_1	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_19,HTH_3
TLS1_k127_2362304_22	1206731.BAGB01000174_gene2074	2.897e-22	108.0	COG0748@1|root,COG0748@2|Bacteria,2I3CW@201174|Actinobacteria,4G8PK@85025|Nocardiaceae	201174|Actinobacteria	P	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
TLS1_k127_2362304_6	867845.KI911784_gene456	5.866e-80	276.0	COG2041@1|root,COG2041@2|Bacteria,2G6ES@200795|Chloroflexi,376JM@32061|Chloroflexia	32061|Chloroflexia	S	PFAM oxidoreductase, molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
TLS1_k127_2362304_5	1340493.JNIF01000003_gene2775	1.886e-82	286.0	COG1216@1|root,COG1216@2|Bacteria,3Y9AS@57723|Acidobacteria	57723|Acidobacteria	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS1_k127_2362304_23	269799.Gmet_1389	1.199e-19	104.0	COG0392@1|root,COG0392@2|Bacteria,1R98C@1224|Proteobacteria,42U6V@68525|delta/epsilon subdivisions,2WKTZ@28221|Deltaproteobacteria,43W1F@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
TLS1_k127_2362304_13	929712.KI912613_gene3618	5.307e-53	200.0	COG1732@1|root,COG1732@2|Bacteria,2GJWY@201174|Actinobacteria	201174|Actinobacteria	M	Glycine betaine	-	-	-	ko:K05845	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
TLS1_k127_2362304_8	1123320.KB889585_gene1790	2.457e-59	223.0	COG1174@1|root,COG1174@2|Bacteria,2GYTC@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter (Permease)	proW	-	-	ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
TLS1_k127_2362304_10	1380354.JIAN01000007_gene312	3.802e-57	207.0	COG1174@1|root,COG1174@2|Bacteria,2GMU0@201174|Actinobacteria,4F1KA@85016|Cellulomonadaceae	201174|Actinobacteria	E	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
TLS1_k127_2362304_3	1312959.KI914692_gene2794	4.237e-118	392.0	COG1125@1|root,COG1125@2|Bacteria,2GJHI@201174|Actinobacteria,1W80J@1268|Micrococcaceae	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran,CBS
TLS1_k127_2362304_9	509190.Cseg_0260	8.023e-59	211.0	COG3897@1|root,COG3897@2|Bacteria,1N9VC@1224|Proteobacteria,2TV6N@28211|Alphaproteobacteria,2KFN9@204458|Caulobacterales	204458|Caulobacterales	S	L11 methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PrmA
TLS1_k127_2362304_11	1229780.BN381_810009	5.166e-54	204.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria	201174|Actinobacteria	C	F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS1_k127_2362304_19	1464048.JNZS01000010_gene5078	8.188e-34	138.0	COG3153@1|root,COG3153@2|Bacteria,2IKX0@201174|Actinobacteria,4DEKI@85008|Micromonosporales	201174|Actinobacteria	S	Acetyltransferase (GNAT) domain	-	-	-	ko:K03824,ko:K09964	-	-	-	-	ko00000,ko01000	-	-	-	ACT_3,ACT_7,Acetyltransf_1,Acetyltransf_7,Acetyltransf_9
TLS1_k127_2362304_18	471857.Svir_31300	1.658e-34	141.0	COG1670@1|root,COG1670@2|Bacteria,2IKXU@201174|Actinobacteria,4E52E@85010|Pseudonocardiales	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS1_k127_2362304_1	1128421.JAGA01000002_gene991	5.462e-132	438.0	COG1793@1|root,COG1793@2|Bacteria,2NPKI@2323|unclassified Bacteria	2|Bacteria	L	ATP dependent DNA ligase C terminal region	lig	GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
TLS1_k127_2369137_4	1048339.KB913029_gene4211	1.355e-34	136.0	COG1051@1|root,COG1051@2|Bacteria,2IQZT@201174|Actinobacteria,4ETJ9@85013|Frankiales	201174|Actinobacteria	F	PFAM NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS1_k127_2369137_5	479434.Sthe_1005	5.422e-16	89.0	COG2867@1|root,COG2867@2|Bacteria	2|Bacteria	I	negative regulation of translational initiation	-	-	-	ko:K05554,ko:K15885	ko01056,ko01130,map01056,map01130	M00778	R09265,R09268	RC02546,RC02547	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	-	-	-	Polyketide_cyc,Polyketide_cyc2
TLS1_k127_2369137_1	240016.ABIZ01000001_gene2166	2.692e-94	336.0	COG0304@1|root,COG0304@2|Bacteria,46U2G@74201|Verrucomicrobia,2IWM2@203494|Verrucomicrobiae	203494|Verrucomicrobiae	IQ	Beta-ketoacyl synthase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TLS1_k127_2369137_3	1379270.AUXF01000007_gene919	3.594e-44	176.0	COG5587@1|root,COG5587@2|Bacteria,1ZTH8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Conserved hypothetical protein (DUF2461)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2461
TLS1_k127_2369137_2	316274.Haur_1012	1.419e-64	234.0	COG0454@1|root,COG1246@1|root,COG0456@2|Bacteria,COG1246@2|Bacteria,2G8UQ@200795|Chloroflexi	200795|Chloroflexi	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS1_k127_2369137_0	1122611.KB903958_gene4100	2.386e-97	321.0	COG0274@1|root,COG0274@2|Bacteria,2GJIR@201174|Actinobacteria,4EIC0@85012|Streptosporangiales	201174|Actinobacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
TLS1_k127_2382075_13	1173028.ANKO01000250_gene2316	4.641e-42	164.0	COG0130@1|root,COG0130@2|Bacteria,1G0S5@1117|Cyanobacteria,1H839@1150|Oscillatoriales	1117|Cyanobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
TLS1_k127_2382075_12	485913.Krac_11249	2.101e-48	191.0	COG0618@1|root,COG0618@2|Bacteria,2G6RF@200795|Chloroflexi	200795|Chloroflexi	S	PFAM phosphoesterase, RecJ domain protein	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
TLS1_k127_2382075_16	1121422.AUMW01000003_gene949	7.069e-27	117.0	COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,24MPB@186801|Clostridia,262H0@186807|Peptococcaceae	186801|Clostridia	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
TLS1_k127_2382075_0	1121428.DESHY_80091___1	7.286e-204	652.0	COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,248SJ@186801|Clostridia,260ER@186807|Peptococcaceae	186801|Clostridia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
TLS1_k127_2382075_17	243164.DET0984	1.38e-18	91.0	COG2740@1|root,COG2740@2|Bacteria,2G72H@200795|Chloroflexi,34DJN@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Protein of unknown function (DUF448)	-	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448
TLS1_k127_2382075_2	498761.HM1_2310	6.254e-111	376.0	COG0195@1|root,COG0195@2|Bacteria,1TPB3@1239|Firmicutes,247W8@186801|Clostridia	186801|Clostridia	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
TLS1_k127_2382075_1	861299.J421_1297	9.062e-186	588.0	COG0821@1|root,COG0821@2|Bacteria,1ZST3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
TLS1_k127_2382075_10	525904.Tter_1705	1.291e-56	221.0	COG0750@1|root,COG0750@2|Bacteria,2NP7C@2323|unclassified Bacteria	2|Bacteria	M	zinc metalloprotease	rseP	GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016021,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0040007,GO:0043170,GO:0043856,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0045152,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:0140110,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	3.4.21.107	ko:K04771,ko:K11749,ko:K16922	ko01503,ko02020,ko02024,ko04112,map01503,map02020,map02024,map04112	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Peptidase_M50
TLS1_k127_2382075_3	479434.Sthe_1740	2.62e-100	340.0	COG0743@1|root,COG0743@2|Bacteria,2G5RB@200795|Chloroflexi,27Y4B@189775|Thermomicrobia	189775|Thermomicrobia	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
TLS1_k127_2382075_15	316274.Haur_3934	2.457e-37	160.0	COG4589@1|root,COG4589@2|Bacteria,2G6QV@200795|Chloroflexi,375K2@32061|Chloroflexia	32061|Chloroflexia	M	Belongs to the CDS family	-	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
TLS1_k127_2382075_7	525904.Tter_1516	1.537e-70	256.0	COG0020@1|root,COG0020@2|Bacteria,2NP9M@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617	2.5.1.31,2.5.1.68	ko:K00806,ko:K12503	ko00900,ko01110,map00900,map01110	-	R06447,R08528	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
TLS1_k127_2382075_11	635013.TherJR_1359	3.391e-53	205.0	COG0233@1|root,COG0233@2|Bacteria,1V1F2@1239|Firmicutes,24HWS@186801|Clostridia,261N9@186807|Peptococcaceae	186801|Clostridia	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
TLS1_k127_2382075_4	111780.Sta7437_3943	5.967e-94	321.0	COG0528@1|root,COG0528@2|Bacteria,1G0CR@1117|Cyanobacteria,3VICS@52604|Pleurocapsales	1117|Cyanobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
TLS1_k127_2382075_8	1089548.KI783301_gene682	5.355e-67	234.0	COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,4HBDV@91061|Bacilli,3WDWK@539002|Bacillales incertae sedis	91061|Bacilli	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	GO:0001871,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005623,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0019538,GO:0030246,GO:0030247,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
TLS1_k127_2382075_5	525904.Tter_1520	5.11e-87	303.0	COG0052@1|root,COG0052@2|Bacteria,2NP4M@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
TLS1_k127_2382075_18	477974.Daud_0666	1.762e-10	68.0	COG0792@1|root,COG0792@2|Bacteria,1VFHQ@1239|Firmicutes,24QNK@186801|Clostridia,262QF@186807|Peptococcaceae	186801|Clostridia	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
TLS1_k127_2382075_9	395961.Cyan7425_1166	4.996e-61	219.0	COG0164@1|root,COG0164@2|Bacteria,1G507@1117|Cyanobacteria,3KHNX@43988|Cyanothece	1117|Cyanobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
TLS1_k127_2382075_14	1385510.N781_12315	2.97e-38	150.0	COG0335@1|root,COG0335@2|Bacteria,1V6FT@1239|Firmicutes,4HIK3@91061|Bacilli,2YAG5@289201|Pontibacillus	91061|Bacilli	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
TLS1_k127_2382075_6	1410658.JHWI01000014_gene985	1.869e-75	260.0	COG0336@1|root,COG0336@2|Bacteria,1TPBV@1239|Firmicutes,3VPPW@526524|Erysipelotrichia	526524|Erysipelotrichia	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
TLS1_k127_2436074_10	1122994.AUFR01000037_gene1163	5.98e-20	98.0	COG0699@1|root,COG0699@2|Bacteria,2GJX9@201174|Actinobacteria,4DPB6@85009|Propionibacteriales	201174|Actinobacteria	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
TLS1_k127_2436074_5	367299.JOEE01000003_gene2812	5.471e-40	168.0	COG0699@1|root,COG0699@2|Bacteria,2GM68@201174|Actinobacteria,4FFJF@85021|Intrasporangiaceae	201174|Actinobacteria	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N,MMR_HSR1
TLS1_k127_2436074_7	1089552.KI911559_gene2701	6.912e-27	124.0	COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,2U5H1@28211|Alphaproteobacteria,2JRQN@204441|Rhodospirillales	204441|Rhodospirillales	EGP	COG0477 Permeases of the major facilitator superfamily	-	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
TLS1_k127_2436074_3	266940.Krad_0365	1.003e-55	207.0	COG3391@1|root,COG3391@2|Bacteria,2I3GE@201174|Actinobacteria	201174|Actinobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_2436074_11	1246995.AFR_39605	4.256e-13	79.0	COG1309@1|root,COG1309@2|Bacteria,2GZ1Y@201174|Actinobacteria,4DDXG@85008|Micromonosporales	201174|Actinobacteria	K	BetI-type transcriptional repressor, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
TLS1_k127_2436074_1	266117.Rxyl_0961	9.729e-74	260.0	COG1478@1|root,COG1478@2|Bacteria,2GMJ8@201174|Actinobacteria,4CQ5F@84995|Rubrobacteria	84995|Rubrobacteria	C	F420-0:Gamma-glutamyl ligase	-	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
TLS1_k127_2436074_8	309801.trd_A0802	2.416e-26	119.0	COG1920@1|root,COG1920@2|Bacteria,2G76R@200795|Chloroflexi,27YIQ@189775|Thermomicrobia	189775|Thermomicrobia	H	Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor	cofC	-	2.7.7.68	ko:K14941	ko00680,ko01120,map00680,map01120	M00378	R09397	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC
TLS1_k127_2436074_4	402777.KB235903_gene1332	1.133e-47	180.0	COG1279@1|root,COG1279@2|Bacteria,1GQJ3@1117|Cyanobacteria,1HHX6@1150|Oscillatoriales	1117|Cyanobacteria	S	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
TLS1_k127_2436074_0	309801.trd_A0801	3.446e-94	322.0	COG0391@1|root,COG0391@2|Bacteria,2G5S2@200795|Chloroflexi,27Y2F@189775|Thermomicrobia	189775|Thermomicrobia	S	Uncharacterised protein family UPF0052	-	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
TLS1_k127_2436074_2	1380390.JIAT01000013_gene70	1.039e-61	224.0	COG2141@1|root,COG2141@2|Bacteria,2GM7W@201174|Actinobacteria,4CQA5@84995|Rubrobacteria	84995|Rubrobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS1_k127_2436074_6	479434.Sthe_2501	6.182e-30	128.0	COG3467@1|root,COG3467@2|Bacteria,2G77X@200795|Chloroflexi	200795|Chloroflexi	S	PFAM pyridoxamine 5'-phosphate oxidase-related	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS1_k127_2436074_9	882.DVU_1959	3.729e-24	106.0	COG0517@1|root,COG2199@1|root,COG2200@1|root,COG0517@2|Bacteria,COG2199@2|Bacteria,COG2200@2|Bacteria,1MVJY@1224|Proteobacteria,42N7E@68525|delta/epsilon subdivisions,2WK3K@28221|Deltaproteobacteria,2M7U9@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	TIGRFAM Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,EAL,GGDEF
TLS1_k127_2440743_0	1382356.JQMP01000004_gene583	4.24e-285	889.0	COG0365@1|root,COG0365@2|Bacteria,2G5KE@200795|Chloroflexi,27XEK@189775|Thermomicrobia	189775|Thermomicrobia	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
TLS1_k127_2440743_1	2342.SOPEG_3264	6.173e-64	226.0	COG0546@1|root,COG0546@2|Bacteria,1QUR1@1224|Proteobacteria	1224|Proteobacteria	S	HAD-hyrolase-like	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	Hydrolase
TLS1_k127_2440743_2	1122609.AUGT01000012_gene4252	4.968e-21	106.0	COG4963@1|root,COG4963@2|Bacteria,2GNHI@201174|Actinobacteria,4DR78@85009|Propionibacteriales	201174|Actinobacteria	D	NUBPL iron-transfer P-loop NTPase	flpE	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CbiA,ParA
TLS1_k127_244130_0	1048834.TC41_0430	4.216e-145	467.0	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,4H9MF@91061|Bacilli	91061|Bacilli	C	Belongs to the aldehyde dehydrogenase family	aldHT_1	-	-	ko:K22187	ko00040,map00040	-	R11768	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
TLS1_k127_244130_3	235985.BBPN01000050_gene8352	4.143e-17	90.0	COG0454@1|root,COG0456@2|Bacteria,2IPIF@201174|Actinobacteria,2NMID@228398|Streptacidiphilus	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS1_k127_244130_1	1380390.JIAT01000011_gene2348	1.424e-140	475.0	COG1366@1|root,COG2409@1|root,COG1366@2|Bacteria,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4CR8Y@84995|Rubrobacteria	84995|Rubrobacteria	T	MMPL family	-	-	-	-	-	-	-	-	-	-	-	-	MMPL,STAS_2
TLS1_k127_244130_2	323261.Noc_0230	4.508e-52	197.0	COG3055@1|root,COG3055@2|Bacteria,1QSB4@1224|Proteobacteria,1S2EP@1236|Gammaproteobacteria,1WZIK@135613|Chromatiales	135613|Chromatiales	S	Galactose oxidase, central domain	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_6
TLS1_k127_244130_4	1123035.ARLA01000027_gene402	3.799e-10	67.0	COG5164@1|root,COG5295@1|root,COG5164@2|Bacteria,COG5295@2|Bacteria,4PHV9@976|Bacteroidetes,1IEJ9@117743|Flavobacteriia,4C4EI@83612|Psychroflexus	976|Bacteroidetes	UW	Hep Hag repeat protein	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	-
TLS1_k127_2558603_1	326424.FRAAL6066	7.457e-142	470.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4ERS8@85013|Frankiales	201174|Actinobacteria	E	aminotransferase class I and II	aspC	-	2.6.1.1,2.6.1.17,2.6.1.2,2.6.1.66	ko:K00812,ko:K10907,ko:K14260,ko:K14267	ko00220,ko00250,ko00270,ko00290,ko00300,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00290,map00300,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01130,map01210,map01230	M00016	R00258,R00355,R00694,R00734,R00896,R01215,R02433,R02619,R04475,R05052	RC00006,RC00008,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS1_k127_2558603_2	349124.Hhal_1500	2.545e-139	469.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,1RN7H@1236|Gammaproteobacteria,1X0IX@135613|Chromatiales	135613|Chromatiales	S	PFAM peptidase S15	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
TLS1_k127_2558603_12	760192.Halhy_5378	4.137e-54	197.0	COG0494@1|root,COG0494@2|Bacteria,4NMHV@976|Bacteroidetes,1ISBJ@117747|Sphingobacteriia	976|Bacteroidetes	L	NUDIX domain	nudF	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS1_k127_2558603_6	266117.Rxyl_1558	3.632e-109	367.0	COG0665@1|root,COG0665@2|Bacteria,2I9WR@201174|Actinobacteria,4CSWG@84995|Rubrobacteria	84995|Rubrobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
TLS1_k127_2558603_3	1122609.AUGT01000009_gene3347	2.778e-113	393.0	COG0747@1|root,COG0747@2|Bacteria,2GNKN@201174|Actinobacteria,4DPH8@85009|Propionibacteriales	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS1_k127_2558603_5	1297570.MESS4_20067	4.453e-110	364.0	COG0601@1|root,COG0601@2|Bacteria,1R6RG@1224|Proteobacteria,2U10E@28211|Alphaproteobacteria,43R3C@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	U	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	-	ko:K02033,ko:K12369	ko02010,ko02024,map02010,map02024	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS1_k127_2558603_8	1297570.MESS4_20066	5.532e-96	324.0	COG1173@1|root,COG1173@2|Bacteria,1NRWG@1224|Proteobacteria,2UPAF@28211|Alphaproteobacteria,43PKS@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS1_k127_2558603_7	266835.14025831	1.058e-98	345.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,43QYI@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EP	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS1_k127_2558603_4	1297570.MESS4_20064	1.03e-110	388.0	COG4608@1|root,COG4608@2|Bacteria,1NU61@1224|Proteobacteria,2UR5X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,oligo_HPY
TLS1_k127_2558603_13	1121456.ATVA01000019_gene1273	2.628e-53	210.0	COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,42QWV@68525|delta/epsilon subdivisions,2WMPT@28221|Deltaproteobacteria,2MB6B@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM Methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
TLS1_k127_2558603_14	1122939.ATUD01000014_gene1056	1.27e-37	158.0	COG2385@1|root,COG2385@2|Bacteria,2ID9T@201174|Actinobacteria,4CPMQ@84995|Rubrobacteria	84995|Rubrobacteria	D	Stage II sporulation protein	-	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	SpoIID
TLS1_k127_2558603_16	443218.AS9A_1484	1.371e-17	93.0	COG3571@1|root,COG3571@2|Bacteria,2GKKE@201174|Actinobacteria,234V8@1762|Mycobacteriaceae	201174|Actinobacteria	S	hydrolase of the alpha beta-hydrolase fold	-	-	-	ko:K07020	-	-	-	-	ko00000	-	-	-	DLH
TLS1_k127_2558603_9	797209.ZOD2009_10720	4.554e-68	264.0	COG1131@1|root,arCOG00194@2157|Archaea,2XTCU@28890|Euryarchaeota,23SM1@183963|Halobacteria	183963|Halobacteria	E	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS1_k127_2558603_17	1210884.HG799465_gene12130	4.789e-09	69.0	COG1277@1|root,COG1277@2|Bacteria,2J0S8@203682|Planctomycetes	203682|Planctomycetes	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
TLS1_k127_2558603_18	1075090.GOAMR_61_01750	5.028e-07	61.0	COG2334@1|root,COG2334@2|Bacteria,2I5I8@201174|Actinobacteria,4GFBZ@85026|Gordoniaceae	201174|Actinobacteria	S	Ecdysteroid kinase	-	-	-	-	-	-	-	-	-	-	-	-	APH,EcKinase
TLS1_k127_2558603_15	331869.BAL199_12191	4.014e-19	92.0	COG4101@1|root,COG4101@2|Bacteria,1RB8W@1224|Proteobacteria,2TUPM@28211|Alphaproteobacteria,4BRZD@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Cupin	MA20_44940	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS1_k127_2558603_0	1380393.JHVP01000001_gene2285	2.404e-150	506.0	COG1228@1|root,COG1228@2|Bacteria,2IE2S@201174|Actinobacteria	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS1_k127_2558603_10	309801.trd_1612	5.02e-63	232.0	COG2515@1|root,COG2515@2|Bacteria,2G6PX@200795|Chloroflexi,27YZ5@189775|Thermomicrobia	189775|Thermomicrobia	E	Pyridoxal-phosphate dependent enzyme	-	-	4.4.1.15	ko:K05396	ko00270,map00270	-	R01874	RC00382	ko00000,ko00001,ko01000	-	-	-	PALP
TLS1_k127_2558603_11	469383.Cwoe_0731	5.393e-59	220.0	COG1668@1|root,COG1668@2|Bacteria,2I9MY@201174|Actinobacteria	201174|Actinobacteria	CP	ABC-type Na efflux pump, permease	yhaP	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
TLS1_k127_2589049_6	63737.Npun_R6593	5.502e-22	109.0	COG2931@1|root,COG3211@1|root,COG4222@1|root,COG2931@2|Bacteria,COG3211@2|Bacteria,COG4222@2|Bacteria,1GQ3P@1117|Cyanobacteria,1HJ47@1161|Nostocales	1117|Cyanobacteria	Q	Glycerophosphoryl diester phosphodiesterase family	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	Alk_phosphatase,Exo_endo_phos,GDPD,HemolysinCabind,Phytase-like
TLS1_k127_2589049_0	469383.Cwoe_3861	4.167e-159	520.0	COG0665@1|root,COG0665@2|Bacteria,2GJQ9@201174|Actinobacteria,4CRKG@84995|Rubrobacteria	2|Bacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
TLS1_k127_2589049_1	1380391.JIAS01000003_gene1907	8.546e-114	383.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2TU8Q@28211|Alphaproteobacteria,2JZCC@204441|Rhodospirillales	204441|Rhodospirillales	H	Aminotransferase class-III	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
TLS1_k127_2589049_3	105420.BBPO01000005_gene2881	2.674e-55	204.0	COG1414@1|root,COG1414@2|Bacteria,2GM23@201174|Actinobacteria,2NHGX@228398|Streptacidiphilus	201174|Actinobacteria	K	helix_turn_helix isocitrate lyase regulation	allR	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
TLS1_k127_2589049_5	357808.RoseRS_1782	2.002e-30	136.0	COG1073@1|root,COG1073@2|Bacteria,2G8PF@200795|Chloroflexi,377Y4@32061|Chloroflexia	32061|Chloroflexia	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
TLS1_k127_2589049_2	552811.Dehly_1536	2.087e-61	231.0	COG0668@1|root,COG0668@2|Bacteria,2G75W@200795|Chloroflexi,34D81@301297|Dehalococcoidia	301297|Dehalococcoidia	M	Mechanosensitive ion channel	-	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
TLS1_k127_2589049_4	1448389.BAVQ01000003_gene3473	3.591e-35	153.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	pknL	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
TLS1_k127_2594604_1	671143.DAMO_0980	1.073e-225	717.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2NP1J@2323|unclassified Bacteria	2|Bacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_13,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C
TLS1_k127_2594604_6	765420.OSCT_2907	1.271e-17	98.0	COG2905@1|root,COG2905@2|Bacteria,2G9RT@200795|Chloroflexi,375Z7@32061|Chloroflexia	32061|Chloroflexia	T	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS1_k127_2594604_2	671143.DAMO_0981	3.79e-193	626.0	COG1013@1|root,COG1145@1|root,COG1013@2|Bacteria,COG1145@2|Bacteria,2NQV4@2323|unclassified Bacteria	2|Bacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,Fer4_16,Fer4_6,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
TLS1_k127_2594604_8	1137271.AZUM01000001_gene1100	1.857e-13	81.0	COG0716@1|root,COG0716@2|Bacteria,2IQZD@201174|Actinobacteria,4E5JA@85010|Pseudonocardiales	201174|Actinobacteria	C	PFAM Flavodoxin	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	Flavodoxin_1,Flavodoxin_5
TLS1_k127_2594604_7	479434.Sthe_1897	4.813e-16	92.0	COG1714@1|root,COG1714@2|Bacteria	2|Bacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
TLS1_k127_2594604_0	356851.JOAN01000019_gene4397	4.961e-242	756.0	COG3333@1|root,COG3333@2|Bacteria,2GJB2@201174|Actinobacteria,4DA21@85008|Micromonosporales	201174|Actinobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
TLS1_k127_2594604_4	1146883.BLASA_2402	4.36e-42	160.0	2D22U@1|root,3160H@2|Bacteria,2H7EW@201174|Actinobacteria	201174|Actinobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
TLS1_k127_2594604_3	1146883.BLASA_2401	8.693e-132	430.0	COG3181@1|root,COG3181@2|Bacteria,2IS3A@201174|Actinobacteria	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	tctC4	-	-	-	-	-	-	-	-	-	-	-	TctC
TLS1_k127_2594604_5	479434.Sthe_0777	3.6e-40	157.0	COG0465@1|root,COG0465@2|Bacteria,2G5J3@200795|Chloroflexi,27XT6@189775|Thermomicrobia	189775|Thermomicrobia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH1	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,Peptidase_M41
TLS1_k127_2635043_5	1122921.KB898186_gene5221	3.307e-67	244.0	COG0472@1|root,COG0472@2|Bacteria,1TP9V@1239|Firmicutes,4H9KT@91061|Bacilli,26SC1@186822|Paenibacillaceae	91061|Bacilli	M	transferase	tagO	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
TLS1_k127_2635043_1	401526.TcarDRAFT_1429	4.927e-158	512.0	COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,4H1W8@909932|Negativicutes	909932|Negativicutes	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
TLS1_k127_2635043_7	479434.Sthe_0417	1.995e-38	152.0	COG0009@1|root,COG0009@2|Bacteria,2G673@200795|Chloroflexi,27Y7A@189775|Thermomicrobia	189775|Thermomicrobia	J	Telomere recombination	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
TLS1_k127_2635043_8	251221.35211395	2.475e-38	163.0	COG0561@1|root,COG0561@2|Bacteria,1G2FN@1117|Cyanobacteria	1117|Cyanobacteria	S	TIGRFAM Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
TLS1_k127_2635043_6	243164.DET1211	2.054e-47	182.0	COG2890@1|root,COG2890@2|Bacteria,2G6I8@200795|Chloroflexi,34CQQ@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
TLS1_k127_2635043_0	1120973.AQXL01000111_gene924	3.275e-175	576.0	COG3408@1|root,COG3408@2|Bacteria,1TPX8@1239|Firmicutes,4HDVV@91061|Bacilli,2799W@186823|Alicyclobacillaceae	91061|Bacilli	G	N-terminal domain of (some) glycogen debranching enzymes	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N_bis
TLS1_k127_2635043_2	585394.RHOM_09575	8.203e-105	366.0	COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,248CN@186801|Clostridia	186801|Clostridia	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
TLS1_k127_2635043_4	255470.cbdbA1275	2.518e-72	258.0	COG3872@1|root,COG3872@2|Bacteria,2G5XQ@200795|Chloroflexi,34D3S@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Protein of unknown function (DUF1385)	-	-	-	ko:K09153	-	-	-	-	ko00000	-	-	-	DUF1385
TLS1_k127_2635043_3	694431.DESACE_08920	2.109e-80	270.0	COG2189@1|root,COG2189@2|Bacteria	2|Bacteria	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.72	ko:K00571,ko:K07319	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
TLS1_k127_2730685_0	479434.Sthe_0519	3.468e-116	381.0	COG4962@1|root,COG4962@2|Bacteria,2G68E@200795|Chloroflexi,27XTR@189775|Thermomicrobia	189775|Thermomicrobia	U	Type II/IV secretion system protein	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
TLS1_k127_2730685_1	357808.RoseRS_1273	5.328e-103	349.0	COG4753@1|root,COG4963@1|root,COG4753@2|Bacteria,COG4963@2|Bacteria,2G6CH@200795|Chloroflexi,37524@32061|Chloroflexia	32061|Chloroflexia	D	PFAM response regulator receiver	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,ParA,Response_reg
TLS1_k127_2730685_3	1121472.AQWN01000010_gene596	2.501e-07	62.0	COG3745@1|root,COG3745@2|Bacteria,1V5FZ@1239|Firmicutes,24I7V@186801|Clostridia,262WB@186807|Peptococcaceae	186801|Clostridia	U	Flp pilus assembly protein RcpC/CpaB	-	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
TLS1_k127_2730685_4	429009.Adeg_1035	0.0004736	48.0	COG3847@1|root,COG3847@2|Bacteria,1VKJ4@1239|Firmicutes,24UMJ@186801|Clostridia,42HJV@68295|Thermoanaerobacterales	186801|Clostridia	U	Flp/Fap pilin component	-	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Flp_Fap
TLS1_k127_2730685_6	1121324.CLIT_23c00450	0.0008554	47.0	2EHTG@1|root,33BJ4@2|Bacteria	2|Bacteria	S	Flp Fap pilin component	-	-	-	-	-	-	-	-	-	-	-	-	Flp_Fap
TLS1_k127_2730685_5	1382356.JQMP01000003_gene2106	0.0006968	44.0	COG3847@1|root,COG3847@2|Bacteria,2GA5Y@200795|Chloroflexi,27ZCI@189775|Thermomicrobia	189775|Thermomicrobia	U	Flp/Fap pilin component	-	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Flp_Fap
TLS1_k127_2730685_2	1521187.JPIM01000065_gene1267	1.521e-30	134.0	COG4585@1|root,COG4585@2|Bacteria,2G71C@200795|Chloroflexi,3752U@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase, dimerisation and phosphoacceptor region	-	-	2.7.13.3	ko:K07777	ko02020,map02020	M00478	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DegS,HATPase_c,HisKA_3
TLS1_k127_2755073_3	204669.Acid345_1688	1.095e-72	259.0	COG4354@1|root,COG4354@2|Bacteria,3Y2ZY@57723|Acidobacteria,2JHZE@204432|Acidobacteriia	204432|Acidobacteriia	G	beta-glucosidase 2, glycosyl-hydrolase family 116 N-term	-	-	3.2.1.45	ko:K17108	ko00511,ko00600,ko01100,map00511,map00600,map01100	-	R01498	RC00059,RC00451	ko00000,ko00001,ko01000	-	GH116	-	DUF608,Glyco_hydr_116N
TLS1_k127_2755073_1	326427.Cagg_1688	1.482e-107	363.0	COG0395@1|root,COG0395@2|Bacteria,2G7M8@200795|Chloroflexi,37780@32061|Chloroflexia	32061|Chloroflexia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS1_k127_2755073_2	1463821.JOGR01000010_gene3654	3.736e-80	278.0	COG1175@1|root,COG1175@2|Bacteria,2HHFB@201174|Actinobacteria	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS1_k127_2755073_0	1463821.JOGR01000010_gene3655	1.718e-126	419.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
TLS1_k127_2808757_2	356851.JOAN01000002_gene741	8.788e-132	434.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4DBNS@85008|Micromonosporales	201174|Actinobacteria	C	Aldehyde dehydrogenase family	xylC	-	1.2.1.28	ko:K00141	ko00622,ko00623,ko00627,ko01100,ko01120,ko01220,map00622,map00623,map00627,map01100,map01120,map01220	M00537,M00538	R01293,R01419,R05289,R05663,R05664,R07667	RC00075	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS1_k127_2808757_6	345341.KUTG_03654	1.449e-15	91.0	28UGN@1|root,2ZGMH@2|Bacteria,2IT7C@201174|Actinobacteria,4ECG7@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_2808757_0	1445613.JALM01000138_gene3345	3.194e-241	778.0	COG2303@1|root,COG2303@2|Bacteria,2I5YA@201174|Actinobacteria,4E1GQ@85010|Pseudonocardiales	201174|Actinobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N,NAD_binding_8
TLS1_k127_2808757_5	1341151.ASZU01000020_gene1060	1.048e-57	222.0	COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,4HA95@91061|Bacilli,27B2J@186824|Thermoactinomycetaceae	91061|Bacilli	M	Alanine racemase, C-terminal domain	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
TLS1_k127_2808757_3	477641.MODMU_2389	1.539e-86	294.0	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	idnO	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
TLS1_k127_2808757_1	477641.MODMU_2390	1.127e-137	456.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	-	ko:K05555	ko01057,ko01130,map01057,map01130	M00778	R09305	-	ko00000,ko00001,ko00002,ko01000,ko01008	-	-	-	Lactamase_B
TLS1_k127_2808757_4	1415166.NONO_c58960	1.281e-69	252.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria,4FVX8@85025|Nocardiaceae	201174|Actinobacteria	G	PEP-utilising enzyme, mobile domain	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
TLS1_k127_2832204_3	1128421.JAGA01000002_gene426	1.46e-20	93.0	COG1917@1|root,COG1917@2|Bacteria,2NRCD@2323|unclassified Bacteria	2|Bacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS1_k127_2832204_2	1304874.JAFY01000002_gene855	3.221e-32	139.0	COG2423@1|root,COG2423@2|Bacteria,3TAM0@508458|Synergistetes	508458|Synergistetes	E	Ornithine cyclodeaminase mu-crystallin family	-	-	1.4.1.1,4.3.1.12	ko:K01750,ko:K19244	ko00250,ko00330,ko00430,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map01100,map01110,map01130,map01230	-	R00396,R00671	RC00008,RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
TLS1_k127_2832204_0	471852.Tcur_1568	3.197e-177	589.0	COG2366@1|root,COG2366@2|Bacteria,2GISQ@201174|Actinobacteria,4EFUH@85012|Streptosporangiales	201174|Actinobacteria	S	Penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
TLS1_k127_2832204_4	1300345.LF41_1942	3.386e-14	77.0	COG2146@1|root,COG2146@2|Bacteria,1N8PE@1224|Proteobacteria,1S6B0@1236|Gammaproteobacteria,1X8WP@135614|Xanthomonadales	135614|Xanthomonadales	P	Rieske [2Fe-2S] domain	-	-	-	ko:K18087	ko00621,ko01100,ko01120,ko01220,map00621,map01100,map01120,map01220	M00543	R05261,R05262,R05263,R05264	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
TLS1_k127_2832204_1	383372.Rcas_0305	9.06e-50	195.0	COG0719@1|root,COG0719@2|Bacteria,2G5S8@200795|Chloroflexi,375CG@32061|Chloroflexia	32061|Chloroflexia	O	TIGRFAM FeS assembly protein SufD	-	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
TLS1_k127_2832204_5	1034769.KB910518_gene512	2.624e-13	69.0	COG0719@1|root,COG0719@2|Bacteria,1TQ21@1239|Firmicutes,4HA1Z@91061|Bacilli,26RD7@186822|Paenibacillaceae	91061|Bacilli	O	Fe-S cluster assembly protein SufB	sufB	-	-	ko:K07033,ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
TLS1_k127_2836594_11	767817.Desgi_0597	8.76e-17	83.0	COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia,260XK@186807|Peptococcaceae	186801|Clostridia	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TLS1_k127_2836594_1	1128421.JAGA01000002_gene1560	6.126e-188	607.0	COG0119@1|root,COG0119@2|Bacteria,2NNVW@2323|unclassified Bacteria	2|Bacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	cimA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
TLS1_k127_2836594_12	1231241.Mc24_08739	1.14e-10	71.0	COG0119@1|root,COG0119@2|Bacteria	2|Bacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA	GO:0003674,GO:0003824,GO:0003852,GO:0003985,GO:0003988,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046912,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS10690,iSFV_1184.SFV_0066,iYO844.BSU28280	HMGL-like,LeuA_dimer
TLS1_k127_2836594_8	1382306.JNIM01000001_gene720	1.313e-60	220.0	COG0077@1|root,COG0077@2|Bacteria,2G6AP@200795|Chloroflexi	200795|Chloroflexi	E	amino acid-binding ACT domain protein	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	PDT
TLS1_k127_2836594_2	1385521.N803_09610	2.962e-155	511.0	COG0433@1|root,COG0433@2|Bacteria,2GM12@201174|Actinobacteria,4FERS@85021|Intrasporangiaceae	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF853)	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
TLS1_k127_2836594_9	479431.Namu_3569	8.99e-35	145.0	COG1192@1|root,COG1192@2|Bacteria,2GMU7@201174|Actinobacteria,4ERFS@85013|Frankiales	201174|Actinobacteria	D	PFAM Cobyrinic acid a,c-diamide synthase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31
TLS1_k127_2836594_5	234267.Acid_1081	3.46e-97	327.0	COG2326@1|root,COG2326@2|Bacteria,3Y44F@57723|Acidobacteria	57723|Acidobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
TLS1_k127_2836594_0	309801.trd_1468	2.75e-192	611.0	COG1012@1|root,COG1012@2|Bacteria,2G5NY@200795|Chloroflexi,27XK3@189775|Thermomicrobia	189775|Thermomicrobia	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
TLS1_k127_2836594_10	525904.Tter_2098	5.648e-19	102.0	COG4733@1|root,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	CelD_N,Glyco_hydro_9,fn3
TLS1_k127_2836594_6	1089552.KI911559_gene814	5.421e-85	307.0	2CC5D@1|root,2ZAC9@2|Bacteria,1R5ZC@1224|Proteobacteria	1224|Proteobacteria	S	Alginate lyase	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_lyase
TLS1_k127_2836594_3	981369.JQMJ01000004_gene3848	5.86e-129	426.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,2NHEP@228398|Streptacidiphilus	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS1_k127_2836594_4	479434.Sthe_0533	1.018e-106	380.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2G5QB@200795|Chloroflexi,27XKK@189775|Thermomicrobia	189775|Thermomicrobia	C	Succinyl-CoA ligase like flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
TLS1_k127_2836594_7	37919.EP51_05895	6.69e-61	229.0	COG1024@1|root,COG1024@2|Bacteria,2GN3P@201174|Actinobacteria,4FVWI@85025|Nocardiaceae	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS1_k127_2867198_13	1380394.JADL01000010_gene4398	1.04e-10	68.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,2JUAA@204441|Rhodospirillales	204441|Rhodospirillales	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
TLS1_k127_2867198_2	1298863.AUEP01000008_gene1247	2.893e-146	475.0	COG0404@1|root,COG0404@2|Bacteria,2I8C4@201174|Actinobacteria,4DTFF@85009|Propionibacteriales	201174|Actinobacteria	E	Glycine cleavage T-protein C-terminal barrel domain	-	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1989,GCV_T,GCV_T_C
TLS1_k127_2867198_1	1035308.AQYY01000002_gene650	6.611e-167	534.0	COG0477@1|root,COG2814@2|Bacteria,1TUM8@1239|Firmicutes,24SPE@186801|Clostridia	186801|Clostridia	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS1_k127_2867198_5	1283299.AUKG01000003_gene197	5.867e-33	148.0	COG1451@1|root,COG1451@2|Bacteria,2HQ1W@201174|Actinobacteria,4CRI6@84995|Rubrobacteria	84995|Rubrobacteria	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
TLS1_k127_2867198_6	351607.Acel_0938	1.139e-28	122.0	COG0703@1|root,COG0703@2|Bacteria,2IQZ8@201174|Actinobacteria,4EW56@85013|Frankiales	201174|Actinobacteria	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	-	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
TLS1_k127_2867198_11	204669.Acid345_2164	5.233e-19	96.0	COG2318@1|root,COG2318@2|Bacteria,3Y501@57723|Acidobacteria,2JJGU@204432|Acidobacteriia	204432|Acidobacteriia	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS1_k127_2867198_7	1177154.Y5S_03189	1.321e-27	124.0	COG3019@1|root,COG3019@2|Bacteria,1MZ9V@1224|Proteobacteria,1S9CQ@1236|Gammaproteobacteria,1XKTR@135619|Oceanospirillales	135619|Oceanospirillales	S	metal-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF411
TLS1_k127_2867198_3	479434.Sthe_0069	3.915e-68	239.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Nitroreductase
TLS1_k127_2867198_10	999541.bgla_2g04130	1.16e-20	103.0	COG0697@1|root,COG0697@2|Bacteria,1RK3D@1224|Proteobacteria,2W816@28216|Betaproteobacteria,1KBTV@119060|Burkholderiaceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS1_k127_2867198_8	1009370.ALO_19932	1.231e-26	123.0	COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,4H2TB@909932|Negativicutes	909932|Negativicutes	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
TLS1_k127_2867198_9	1229203.KI301992_gene1580	5.201e-25	119.0	COG0389@1|root,COG0389@2|Bacteria,2GMZ3@201174|Actinobacteria,3UWGC@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	impB/mucB/samB family	dinB_2	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS
TLS1_k127_2867198_15	479434.Sthe_2046	9.26e-05	49.0	29U2R@1|root,30FC1@2|Bacteria,2G9M3@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_2867198_0	1095767.CAHD01000214_gene688	6.14e-183	627.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4F0IU@85016|Cellulomonadaceae	201174|Actinobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	GO:0000731,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0019985,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042276,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
TLS1_k127_2867198_14	1121362.A605_11910	3.236e-06	61.0	COG1749@1|root,COG2374@1|root,COG1749@2|Bacteria,COG2374@2|Bacteria,2HVE1@201174|Actinobacteria,22K38@1653|Corynebacteriaceae	201174|Actinobacteria	N	extracellular nuclease	nucH	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	Collagen,Exo_endo_phos,LTD,Rib
TLS1_k127_2867198_4	1448860.BBJO01000041_gene1962	1.707e-63	227.0	COG2820@1|root,arCOG01324@2157|Archaea,2XSWN@28890|Euryarchaeota,23SKE@183963|Halobacteria	183963|Halobacteria	F	Uridine phosphorylase	udp2	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
TLS1_k127_2867198_12	255470.cbdbA944	1.229e-14	75.0	29WVC@1|root,30IH0@2|Bacteria,2G9KW@200795|Chloroflexi,34DPM@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_28811_1	401526.TcarDRAFT_0384	3.578e-229	721.0	COG0459@1|root,COG0459@2|Bacteria,1TP1T@1239|Firmicutes,4H29X@909932|Negativicutes	909932|Negativicutes	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
TLS1_k127_28811_4	309801.trd_1301	9.045e-37	144.0	COG0234@1|root,COG0234@2|Bacteria,2G6WW@200795|Chloroflexi,27YJ2@189775|Thermomicrobia	189775|Thermomicrobia	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
TLS1_k127_28811_0	1131814.JAFO01000001_gene3315	0.0	3135.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,2TSAJ@28211|Alphaproteobacteria,3EYBF@335928|Xanthobacteraceae	28211|Alphaproteobacteria	G	Glycosyl hydrolase 36 superfamily, catalytic domain	ndvB	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.321	ko:K13688,ko:K18786	-	-	R10832	RC00397	ko00000,ko01000,ko01003	-	GH94,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
TLS1_k127_28811_3	644966.Tmar_0084	8.688e-46	176.0	COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,248HE@186801|Clostridia,3WD1R@538999|Clostridiales incertae sedis	186801|Clostridia	L	TatD related DNase	tatD	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
TLS1_k127_28811_5	1459636.NTE_00830	0.0001157	47.0	COG3324@1|root,arCOG04946@2157|Archaea	2157|Archaea	S	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	-
TLS1_k127_28811_2	443254.Marpi_1941	5.284e-98	334.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,2GCDP@200918|Thermotogae	200918|Thermotogae	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
TLS1_k127_2912898_1	926569.ANT_27600	1.097e-90	311.0	COG0578@1|root,COG0578@2|Bacteria,2G63S@200795|Chloroflexi	200795|Chloroflexi	C	PFAM FAD dependent oxidoreductase	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,Fer2_BFD
TLS1_k127_2912898_2	1173264.KI913949_gene464	3.278e-88	306.0	COG2084@1|root,COG2084@2|Bacteria,1G1GH@1117|Cyanobacteria,1H8UU@1150|Oscillatoriales	1117|Cyanobacteria	I	NAD binding domain of 6-phosphogluconate dehydrogenase	mmsB	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
TLS1_k127_2912898_0	234267.Acid_4739	2.535e-141	473.0	COG0205@1|root,COG0205@2|Bacteria,3Y4A9@57723|Acidobacteria	57723|Acidobacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	-	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
TLS1_k127_2912898_4	867903.ThesuDRAFT_00448	2.541e-26	125.0	COG0590@1|root,COG0590@2|Bacteria,1V3HZ@1239|Firmicutes,24JM2@186801|Clostridia,3WCJG@538999|Clostridiales incertae sedis	186801|Clostridia	F	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
TLS1_k127_2912898_3	644966.Tmar_0072	2.208e-87	304.0	COG2812@1|root,COG2812@2|Bacteria,1TPS9@1239|Firmicutes,247J7@186801|Clostridia,3WCEF@538999|Clostridiales incertae sedis	186801|Clostridia	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
TLS1_k127_3022773_2	1463934.JOCF01000085_gene618	1.006e-92	319.0	COG0624@1|root,COG0624@2|Bacteria,2GMH2@201174|Actinobacteria	201174|Actinobacteria	E	peptidase	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS1_k127_3022773_6	1146883.BLASA_2266	3.786e-32	136.0	COG0251@1|root,COG0251@2|Bacteria,2IIB2@201174|Actinobacteria,4ETK2@85013|Frankiales	201174|Actinobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
TLS1_k127_3022773_7	1121378.KB899720_gene249	2.305e-27	122.0	COG1296@1|root,COG1296@2|Bacteria,1WJG7@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Branched-chain amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AzlC
TLS1_k127_3022773_1	479434.Sthe_1347	2.103e-125	421.0	COG0405@1|root,COG0405@2|Bacteria,2G5R2@200795|Chloroflexi,27Y0Y@189775|Thermomicrobia	189775|Thermomicrobia	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
TLS1_k127_3022773_4	1382306.JNIM01000001_gene977	4.874e-49	192.0	COG0477@1|root,COG2814@2|Bacteria	1382306.JNIM01000001_gene977|-	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3022773_5	632292.Calhy_0625	3.484e-39	168.0	COG1307@1|root,COG1307@2|Bacteria,1TRM7@1239|Firmicutes,247ST@186801|Clostridia,42GID@68295|Thermoanaerobacterales	186801|Clostridia	S	TIGRFAM degV family protein	-	-	-	-	-	-	-	-	-	-	-	-	DegV
TLS1_k127_3022773_0	525904.Tter_0805	6.924e-171	548.0	COG0334@1|root,COG0334@2|Bacteria,2NNRJ@2323|unclassified Bacteria	2|Bacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
TLS1_k127_3022773_3	497964.CfE428DRAFT_4938	1.286e-66	245.0	COG0857@1|root,COG0857@2|Bacteria,46UEZ@74201|Verrucomicrobia	74201|Verrucomicrobia	C	DRTGG domain	-	-	-	ko:K06873	-	-	-	-	ko00000	-	-	-	AAA_26,DRTGG
TLS1_k127_3022773_8	644283.Micau_0812	8.542e-18	92.0	COG1579@1|root,COG1579@2|Bacteria,2I2XU@201174|Actinobacteria,4DD8T@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
TLS1_k127_3059005_13	479434.Sthe_1981	7.604e-10	69.0	COG4758@1|root,COG4758@2|Bacteria	2|Bacteria	KT	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154
TLS1_k127_3059005_12	479434.Sthe_2978	2.173e-27	117.0	COG0735@1|root,COG0735@2|Bacteria,2G74Y@200795|Chloroflexi,27YIH@189775|Thermomicrobia	189775|Thermomicrobia	P	Ferric uptake regulator family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
TLS1_k127_3059005_9	266117.Rxyl_1141	1.687e-56	211.0	COG0803@1|root,COG0803@2|Bacteria,2GM1K@201174|Actinobacteria	201174|Actinobacteria	P	Belongs to the bacterial solute-binding protein 9 family	-	-	-	ko:K09818	-	M00243	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ZnuA
TLS1_k127_3059005_7	479434.Sthe_2976	4.011e-70	255.0	COG1121@1|root,COG1121@2|Bacteria,2G7X2@200795|Chloroflexi,27XH6@189775|Thermomicrobia	189775|Thermomicrobia	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K09820	-	M00243	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC_tran
TLS1_k127_3059005_6	479434.Sthe_2975	9.863e-75	271.0	COG1108@1|root,COG1108@2|Bacteria,2G6GH@200795|Chloroflexi,27XKB@189775|Thermomicrobia	189775|Thermomicrobia	P	ABC 3 transport family	-	-	-	ko:K09819	-	M00243	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC-3
TLS1_k127_3059005_8	290315.Clim_1144	4.429e-64	223.0	COG1803@1|root,COG1803@2|Bacteria	2|Bacteria	G	methylglyoxal synthase activity	mgsA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0008150,GO:0008152,GO:0008929,GO:0009058,GO:0009438,GO:0009987,GO:0016829,GO:0016835,GO:0016838,GO:0019242,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0071704,GO:1901576	4.2.3.3	ko:K01734	ko00640,ko01120,map00640,map01120	-	R01016	RC00424	ko00000,ko00001,ko01000	-	-	iECUMN_1333.ECUMN_1153,iYL1228.KPN_00992	MGS
TLS1_k127_3059005_11	570268.ANBB01000016_gene3639	3.883e-31	132.0	COG0789@1|root,COG4978@1|root,COG0789@2|Bacteria,COG4978@2|Bacteria,2GMG7@201174|Actinobacteria,4EGWI@85012|Streptosporangiales	201174|Actinobacteria	KT	Bacterial transcription activator, effector binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like,MerR_1
TLS1_k127_3059005_5	928724.SacglDRAFT_03170	3.935e-95	319.0	COG2141@1|root,COG2141@2|Bacteria,2GPA5@201174|Actinobacteria,4E2HG@85010|Pseudonocardiales	201174|Actinobacteria	C	F420-dependent oxidoreductase, MSMEG_2906 family	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS1_k127_3059005_15	1463934.JOCF01000038_gene2244	3.235e-05	56.0	COG3631@1|root,COG3631@2|Bacteria,2IJQH@201174|Actinobacteria	201174|Actinobacteria	S	Limonene-1,2-epoxide hydrolase catalytic domain	-	-	-	ko:K06893	-	-	-	-	ko00000	-	-	-	SnoaL_2
TLS1_k127_3059005_0	1123322.KB904634_gene2428	8.122e-239	752.0	COG0491@1|root,COG0491@2|Bacteria,2IBAX@201174|Actinobacteria	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS1_k127_3059005_1	1123322.KB904634_gene2429	6.017e-161	540.0	COG1501@1|root,COG1501@2|Bacteria,2IDV6@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 31 family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3059005_4	1150864.MILUP08_45148	2.202e-97	334.0	COG0395@1|root,COG0395@2|Bacteria,2GJNJ@201174|Actinobacteria	201174|Actinobacteria	G	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS1_k127_3059005_2	1150864.MILUP08_45150	1.476e-117	385.0	COG1175@1|root,COG1175@2|Bacteria,2GKBJ@201174|Actinobacteria,4DBFS@85008|Micromonosporales	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS1_k127_3059005_3	287986.DV20_21725	9.391e-109	378.0	COG1653@1|root,COG1653@2|Bacteria,2I6SJ@201174|Actinobacteria,4DYE6@85010|Pseudonocardiales	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
TLS1_k127_3059005_10	1449353.JQMQ01000005_gene5315	6.548e-44	166.0	COG1940@1|root,COG1940@2|Bacteria,2GJCQ@201174|Actinobacteria,2NEDV@228398|Streptacidiphilus	201174|Actinobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	ROK
TLS1_k127_3131522_12	1166018.FAES_5399	1.295e-52	191.0	COG4430@1|root,COG4430@2|Bacteria,4NN4Z@976|Bacteroidetes,47PX0@768503|Cytophagia	976|Bacteroidetes	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
TLS1_k127_3131522_14	1415630.U771_14150	5.695e-33	140.0	COG2390@1|root,COG2390@2|Bacteria,1MX3F@1224|Proteobacteria	1224|Proteobacteria	K	Transcriptional regulator	lsrR	-	-	-	-	-	-	-	-	-	-	-	HTH_24,HTH_28,Sigma70_r4,Sugar-bind
TLS1_k127_3131522_9	926550.CLDAP_24790	4.407e-65	249.0	COG1070@1|root,COG1070@2|Bacteria	2|Bacteria	G	xylulokinase activity	-	-	2.7.1.12,2.7.1.17,2.7.1.215,2.7.1.5	ko:K00848,ko:K00851,ko:K00854,ko:K00862	ko00030,ko00040,ko00051,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00040,map00051,map01100,map01110,map01120,map01130,map01200	M00014	R01639,R01737,R01902,R03014,R11536	RC00002,RC00017,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
TLS1_k127_3131522_8	1274374.CBLK010000056_gene201	1.47e-65	255.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,4HAM7@91061|Bacilli,26TIQ@186822|Paenibacillaceae	91061|Bacilli	E	ABC transporter substrate-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS1_k127_3131522_5	266779.Meso_2407	1.673e-73	258.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TT48@28211|Alphaproteobacteria,43R36@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	U	transport systems	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS1_k127_3131522_7	1068980.ARVW01000001_gene7694	2.787e-69	253.0	COG1173@1|root,COG1173@2|Bacteria,2GKAW@201174|Actinobacteria,4EEI1@85010|Pseudonocardiales	201174|Actinobacteria	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TLS1_k127_3131522_4	671143.DAMO_2637	3.645e-85	298.0	COG0402@1|root,COG0402@2|Bacteria,2NPE6@2323|unclassified Bacteria	2|Bacteria	F	Amidohydrolase family	guaD	GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006144,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008892,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0016814,GO:0018756,GO:0019239,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0046098,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072521,GO:1901360,GO:1901564	3.5.4.3	ko:K01487	ko00230,ko01100,map00230,map01100	-	R01676	RC00204	ko00000,ko00001,ko01000	-	-	iEC55989_1330.EC55989_3170,iECED1_1282.ECED1_3343,iECIAI1_1343.ECIAI1_3003,iECSE_1348.ECSE_3147	Amidohydro_1
TLS1_k127_3131522_11	1125863.JAFN01000001_gene2386	3.812e-56	201.0	COG0346@1|root,COG0346@2|Bacteria,1RJF9@1224|Proteobacteria,42TD6@68525|delta/epsilon subdivisions,2WP89@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS1_k127_3131522_2	266940.Krad_1032	1.113e-122	418.0	COG3653@1|root,COG3653@2|Bacteria,2GKMK@201174|Actinobacteria	201174|Actinobacteria	Q	N-acyl-D-aspartate D-glutamate deacylase	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
TLS1_k127_3131522_19	314230.DSM3645_07301	5.127e-06	57.0	COG2199@1|root,COG3706@2|Bacteria,2J108@203682|Planctomycetes	203682|Planctomycetes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
TLS1_k127_3131522_0	861299.J421_2138	8.789e-205	665.0	COG1529@1|root,COG1529@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	pucD	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS1_k127_3131522_13	1254432.SCE1572_35130	4.804e-48	183.0	COG2080@1|root,COG2080@2|Bacteria,1MWA6@1224|Proteobacteria,42RRP@68525|delta/epsilon subdivisions,2WP0I@28221|Deltaproteobacteria,2Z3A6@29|Myxococcales	28221|Deltaproteobacteria	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518,ko:K13483	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Fer2_2
TLS1_k127_3131522_10	861299.J421_2140	5.863e-59	214.0	COG1319@1|root,COG1319@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	-	-	1.17.1.4	ko:K13479	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
TLS1_k127_3131522_16	1341155.FSS13T_13600	2.734e-15	87.0	2AFKC@1|root,315MA@2|Bacteria,4PJSY@976|Bacteroidetes,1IAAY@117743|Flavobacteriia,2NZ4P@237|Flavobacterium	976|Bacteroidetes	S	Protein of unknown function (DUF3788)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3788
TLS1_k127_3131522_17	1231190.NA8A_03405	2.147e-10	66.0	COG0346@1|root,COG0346@2|Bacteria,1RH4X@1224|Proteobacteria,2U9S6@28211|Alphaproteobacteria,43K8Q@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Glyoxalase bleomycin resistance protein dioxygenase	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase,Glyoxalase_2
TLS1_k127_3131522_3	1294143.H681_16500	1.948e-107	370.0	COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,1RNJ9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
TLS1_k127_3131522_15	862751.SACTE_6333	1.658e-27	116.0	2C2H7@1|root,32Z8Q@2|Bacteria,2ITDR@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
TLS1_k127_3131522_18	1038859.AXAU01000019_gene4819	1.261e-08	67.0	2AJDN@1|root,319Z8@2|Bacteria,1NUY6@1224|Proteobacteria,2URJ0@28211|Alphaproteobacteria,3K3VI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3131522_1	411469.EUBHAL_02024	2.29e-164	529.0	COG0176@1|root,COG0176@2|Bacteria,1UYMX@1239|Firmicutes,249D1@186801|Clostridia,25V8E@186806|Eubacteriaceae	186801|Clostridia	G	Pfam:Transaldolase	-	-	-	-	-	-	-	-	-	-	-	-	TAL_FSA
TLS1_k127_3131522_6	926550.CLDAP_10020	8.279e-72	246.0	COG2225@1|root,COG2225@2|Bacteria,2G63R@200795|Chloroflexi	200795|Chloroflexi	H	Belongs to the malate synthase family	aceB	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
TLS1_k127_3142995_5	1306174.JODP01000009_gene6464	6.049e-54	210.0	COG3022@1|root,COG3022@2|Bacteria,2GJPM@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the UPF0246 family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0033194,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:1901700	-	ko:K09861	-	-	-	-	ko00000	-	-	-	H2O2_YaaD
TLS1_k127_3142995_1	290399.Arth_0438	3.787e-114	382.0	2C1EG@1|root,2Z7MZ@2|Bacteria,2GK4W@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3142995_8	999541.bgla_1g20580	1.273e-23	103.0	2EIDG@1|root,33C4V@2|Bacteria,1N0P4@1224|Proteobacteria,2VYCP@28216|Betaproteobacteria,1K9BA@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3142995_6	479434.Sthe_2962	1.564e-36	145.0	COG3467@1|root,COG3467@2|Bacteria	2|Bacteria	T	pyridoxamine 5'-phosphate	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Putative_PNPOx,Pyridox_ox_2
TLS1_k127_3142995_2	1169161.KB897720_gene4032	3.383e-84	285.0	COG0262@1|root,COG0262@2|Bacteria,2GK32@201174|Actinobacteria	201174|Actinobacteria	H	Dihydrofolate reductase	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS1_k127_3142995_7	595537.Varpa_2284	4.627e-24	106.0	COG2315@1|root,COG2315@2|Bacteria,1RKYA@1224|Proteobacteria	1224|Proteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3142995_0	1120950.KB892763_gene5517	5.192e-196	631.0	COG0480@1|root,COG0480@2|Bacteria,2GJ64@201174|Actinobacteria,4DSYV@85009|Propionibacteriales	201174|Actinobacteria	J	Elongation factor G, domain IV	tetM	-	-	ko:K18220	-	-	-	-	br01600,ko00000,ko01504	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
TLS1_k127_3142995_4	1121272.KB903283_gene5048	1.378e-63	226.0	COG0748@1|root,COG0748@2|Bacteria,2IP6Y@201174|Actinobacteria,4DERE@85008|Micromonosporales	201174|Actinobacteria	P	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
TLS1_k127_3151868_10	324602.Caur_0409	4.616e-43	173.0	COG1091@1|root,COG1091@2|Bacteria,2G6NS@200795|Chloroflexi,375G0@32061|Chloroflexia	32061|Chloroflexia	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
TLS1_k127_3151868_4	479434.Sthe_0968	8.101e-112	383.0	COG1088@1|root,COG1088@2|Bacteria,2G5KR@200795|Chloroflexi,27XGB@189775|Thermomicrobia	189775|Thermomicrobia	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
TLS1_k127_3151868_7	1229517.AMFD01000003_gene1540	1.025e-56	210.0	COG1209@1|root,COG1209@2|Bacteria,1V301@1239|Firmicutes,4H9R0@91061|Bacilli,1YB68@1357|Lactococcus	91061|Bacilli	H	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rfbA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TLS1_k127_3151868_16	700015.Corgl_0854	4.29e-19	98.0	COG1792@1|root,COG1792@2|Bacteria,2GJN0@201174|Actinobacteria,4CUZG@84998|Coriobacteriia	84998|Coriobacteriia	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
TLS1_k127_3151868_2	309801.trd_1938	3.015e-136	449.0	COG1077@1|root,COG1077@2|Bacteria,2G62K@200795|Chloroflexi,27XN7@189775|Thermomicrobia	189775|Thermomicrobia	D	Cell division protein FtsA	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
TLS1_k127_3151868_6	926550.CLDAP_08060	3.213e-65	233.0	COG2003@1|root,COG2003@2|Bacteria,2G6BK@200795|Chloroflexi	200795|Chloroflexi	L	Belongs to the UPF0758 family	-	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
TLS1_k127_3151868_17	765952.PUV_14550	0.0001046	55.0	COG1266@1|root,COG1266@2|Bacteria,2JGC1@204428|Chlamydiae	204428|Chlamydiae	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
TLS1_k127_3151868_14	485913.Krac_8842	3.552e-25	113.0	COG0143@1|root,COG0143@2|Bacteria,2G6VG@200795|Chloroflexi	200795|Chloroflexi	J	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	DZR
TLS1_k127_3151868_0	926550.CLDAP_24290	5.855e-196	649.0	COG1615@1|root,COG1615@2|Bacteria	2|Bacteria	S	Uncharacterised protein family (UPF0182)	-	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
TLS1_k127_3151868_1	1174684.EBMC1_13943	3.852e-178	576.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,2TRN0@28211|Alphaproteobacteria,2JZZK@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
TLS1_k127_3151868_11	644283.Micau_4951	2.034e-40	155.0	COG2346@1|root,COG2346@2|Bacteria,2IKPF@201174|Actinobacteria,4DCRN@85008|Micromonosporales	201174|Actinobacteria	S	Bacterial-like globin	glbO	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0015669,GO:0015671,GO:0015893,GO:0016020,GO:0019825,GO:0020037,GO:0036094,GO:0042221,GO:0042493,GO:0044464,GO:0046906,GO:0048037,GO:0050896,GO:0051179,GO:0051234,GO:0071944,GO:0097159,GO:1901363	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
TLS1_k127_3151868_3	1496688.ER33_12665	3.379e-118	393.0	COG0516@1|root,COG0516@2|Bacteria,1G1MX@1117|Cyanobacteria,22S1T@167375|Cyanobium	1117|Cyanobacteria	F	IMP dehydrogenase / GMP reductase domain	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	IMPDH
TLS1_k127_3151868_5	1210908.HSB1_15840	1.528e-95	333.0	COG0477@1|root,arCOG00130@2157|Archaea,2XT8X@28890|Euryarchaeota,23TJU@183963|Halobacteria	183963|Halobacteria	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS1_k127_3151868_12	861299.J421_0662	2.371e-40	157.0	COG2030@1|root,COG2030@2|Bacteria	2|Bacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
TLS1_k127_3151868_13	309801.trd_0200	1.355e-32	133.0	COG3870@1|root,COG3870@2|Bacteria,2G736@200795|Chloroflexi,27YHY@189775|Thermomicrobia	189775|Thermomicrobia	S	Cyclic-di-AMP receptor	-	-	-	-	-	-	-	-	-	-	-	-	CdAMP_rec
TLS1_k127_3151868_15	1380390.JIAT01000010_gene4084	2.654e-21	107.0	COG3437@1|root,COG3437@2|Bacteria,2I49F@201174|Actinobacteria,4CSJV@84995|Rubrobacteria	84995|Rubrobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GGDEF,HD
TLS1_k127_3151868_18	1526927.Plano_1539	0.0004	53.0	COG5662@1|root,COG5662@2|Bacteria,1V446@1239|Firmicutes,4HHFJ@91061|Bacilli,26FQM@186818|Planococcaceae	91061|Bacilli	K	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA,zf-HC2
TLS1_k127_3151868_9	1382356.JQMP01000003_gene1500	1.609e-43	166.0	COG1595@1|root,COG1595@2|Bacteria,2G6UE@200795|Chloroflexi,27Z8H@189775|Thermomicrobia	189775|Thermomicrobia	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS1_k127_3151868_8	1121106.JQKB01000003_gene2555	6.131e-53	195.0	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,2U72D@28211|Alphaproteobacteria,2JRSW@204441|Rhodospirillales	204441|Rhodospirillales	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
TLS1_k127_3207323_0	479434.Sthe_1621	0.0	1289.0	COG0178@1|root,COG0178@2|Bacteria,2G60U@200795|Chloroflexi,27XGQ@189775|Thermomicrobia	189775|Thermomicrobia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	-
TLS1_k127_3207323_4	1128421.JAGA01000002_gene1645	9.784e-104	357.0	COG0469@1|root,COG0469@2|Bacteria,2NNKX@2323|unclassified Bacteria	2|Bacteria	G	Belongs to the pyruvate kinase family	pyk	GO:0003674,GO:0003824,GO:0004743,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	iAF987.Gmet_0122	PK,PK_C
TLS1_k127_3207323_5	1121946.AUAX01000019_gene7789	9.532e-71	250.0	COG2141@1|root,COG2141@2|Bacteria,2HGTQ@201174|Actinobacteria,4DENR@85008|Micromonosporales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS1_k127_3207323_1	926550.CLDAP_19690	1.017e-283	894.0	COG0556@1|root,COG0556@2|Bacteria,2G5SU@200795|Chloroflexi	200795|Chloroflexi	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
TLS1_k127_3207323_10	1031288.AXAA01000037_gene1012	1.611e-08	66.0	COG4961@1|root,COG4961@2|Bacteria,1VFNR@1239|Firmicutes,24R06@186801|Clostridia,36MCG@31979|Clostridiaceae	186801|Clostridia	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
TLS1_k127_3207323_8	1128421.JAGA01000002_gene1848	1.785e-20	107.0	COG4655@1|root,COG4655@2|Bacteria	2|Bacteria	S	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad,Tad_C
TLS1_k127_3207323_9	1382356.JQMP01000003_gene2234	3.534e-09	68.0	COG3745@1|root,COG3745@2|Bacteria,2G7H3@200795|Chloroflexi,27XF4@189775|Thermomicrobia	189775|Thermomicrobia	U	SAF	-	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
TLS1_k127_3207323_7	1382356.JQMP01000004_gene609	8.215e-41	171.0	COG0237@1|root,COG0237@2|Bacteria,2G6RQ@200795|Chloroflexi,27Y6K@189775|Thermomicrobia	189775|Thermomicrobia	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
TLS1_k127_3207323_3	324602.Caur_1049	3.4e-112	387.0	COG0488@1|root,COG0488@2|Bacteria,2G5VD@200795|Chloroflexi,3752Q@32061|Chloroflexia	32061|Chloroflexia	S	PFAM ABC transporter related	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
TLS1_k127_3207323_6	767817.Desgi_1638	1.935e-61	242.0	COG0266@1|root,COG0266@2|Bacteria,1TPM9@1239|Firmicutes,24BH2@186801|Clostridia,260YT@186807|Peptococcaceae	186801|Clostridia	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS1_k127_3207323_2	675635.Psed_3588	3.882e-185	620.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GJY2@201174|Actinobacteria,4DY13@85010|Pseudonocardiales	201174|Actinobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
TLS1_k127_3228082_2	1128421.JAGA01000002_gene468	3.327e-208	657.0	COG0504@1|root,COG0504@2|Bacteria,2NNVG@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1276,iECO103_1326.ECO103_3323,iHN637.CLJU_RS01075,iNJ661.Rv1699,iPC815.YPO3377	CTP_synth_N,GATase
TLS1_k127_3228082_3	861299.J421_5675	2.463e-90	306.0	COG0176@1|root,COG0176@2|Bacteria	2|Bacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
TLS1_k127_3228082_1	1382306.JNIM01000001_gene3234	1.985e-240	756.0	COG3848@1|root,COG3848@2|Bacteria,2G8N4@200795|Chloroflexi	200795|Chloroflexi	T	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers
TLS1_k127_3228082_4	196162.Noca_1174	1.354e-78	272.0	COG1802@1|root,COG1802@2|Bacteria,2GJRM@201174|Actinobacteria,4DWS3@85009|Propionibacteriales	201174|Actinobacteria	K	PFAM regulatory protein GntR HTH	-	-	-	ko:K22293	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
TLS1_k127_3228082_7	477641.MODMU_2395	5.876e-46	185.0	COG1319@1|root,COG1319@2|Bacteria,2IGRP@201174|Actinobacteria	201174|Actinobacteria	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
TLS1_k127_3228082_5	1449126.JQKL01000016_gene2868	8.486e-51	192.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,24J9B@186801|Clostridia,26967@186813|unclassified Clostridiales	186801|Clostridia	C	Psort location Cytoplasmic, score	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
TLS1_k127_3228082_0	477641.MODMU_2393	3.776e-265	848.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4EUBU@85013|Frankiales	201174|Actinobacteria	C	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS1_k127_3228082_6	1223543.GP2_024_00660	5.514e-47	186.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria,4GBJH@85026|Gordoniaceae	201174|Actinobacteria	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
TLS1_k127_3238495_5	1128421.JAGA01000002_gene1728	5.791e-66	241.0	COG0332@1|root,COG0332@2|Bacteria,2NNX5@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
TLS1_k127_3238495_12	485913.Krac_9157	9.678e-17	94.0	COG0511@1|root,COG0511@2|Bacteria,2G94M@200795|Chloroflexi	200795|Chloroflexi	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	-	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
TLS1_k127_3238495_1	644966.Tmar_0951	1.755e-136	462.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,3WCS5@538999|Clostridiales incertae sedis	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TLS1_k127_3238495_8	986075.CathTA2_0806	2.176e-30	135.0	COG0639@1|root,COG0639@2|Bacteria,1VDTG@1239|Firmicutes,4IRYQ@91061|Bacilli	91061|Bacilli	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
TLS1_k127_3238495_7	1132442.KB889752_gene3138	2.204e-42	162.0	COG0764@1|root,COG0764@2|Bacteria,1V6EX@1239|Firmicutes,4HGX1@91061|Bacilli,1ZFJ9@1386|Bacillus	91061|Bacilli	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
TLS1_k127_3238495_0	383372.Rcas_2931	1.747e-161	520.0	COG0439@1|root,COG0439@2|Bacteria,2G5YA@200795|Chloroflexi,375AI@32061|Chloroflexia	32061|Chloroflexia	I	Carbamoyl-phosphate synthetase large chain domain protein	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
TLS1_k127_3238495_13	395964.KE386496_gene3047	5.361e-08	62.0	COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,2U93Y@28211|Alphaproteobacteria,3NBB1@45404|Beijerinckiaceae	28211|Alphaproteobacteria	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009305,GO:0009987,GO:0016049,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
TLS1_k127_3238495_4	300852.55773149	2.803e-86	296.0	COG0825@1|root,COG0825@2|Bacteria,1WJ82@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
TLS1_k127_3238495_3	443144.GM21_0896	3.646e-90	312.0	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,42MAB@68525|delta/epsilon subdivisions,2WP9B@28221|Deltaproteobacteria,43U3E@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
TLS1_k127_3238495_10	469383.Cwoe_1762	1.666e-29	128.0	COG1595@1|root,COG1595@2|Bacteria,2HG39@201174|Actinobacteria,4CP8K@84995|Rubrobacteria	84995|Rubrobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS1_k127_3238495_9	2074.JNYD01000012_gene443	1.101e-29	136.0	COG0340@1|root,COG0340@2|Bacteria,2GN8Q@201174|Actinobacteria,4E356@85010|Pseudonocardiales	201174|Actinobacteria	H	biotin lipoate A B protein ligase	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB
TLS1_k127_3238495_2	309799.DICTH_1256	2.777e-133	437.0	COG0527@1|root,COG0527@2|Bacteria	2|Bacteria	E	aspartate kinase activity	lysC	GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.3,2.7.2.4	ko:K00928,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
TLS1_k127_3238495_6	861299.J421_1638	2.924e-51	193.0	COG1247@1|root,COG1247@2|Bacteria	2|Bacteria	M	phosphinothricin N-acetyltransferase activity	pat	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
TLS1_k127_3238495_11	1382306.JNIM01000001_gene1486	8.786e-26	124.0	COG0412@1|root,COG0412@2|Bacteria	2|Bacteria	Q	carboxymethylenebutenolidase activity	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
TLS1_k127_3256686_0	1382356.JQMP01000003_gene2075	1.836e-283	902.0	COG0458@1|root,COG0458@2|Bacteria,2G5NX@200795|Chloroflexi,27XRT@189775|Thermomicrobia	189775|Thermomicrobia	F	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
TLS1_k127_3256686_3	1380346.JNIH01000029_gene5028	4.406e-60	221.0	COG0637@1|root,COG0637@2|Bacteria,2GMIQ@201174|Actinobacteria	201174|Actinobacteria	Q	hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
TLS1_k127_3256686_4	420324.KI912044_gene3918	1.173e-43	179.0	COG0348@1|root,COG0348@2|Bacteria,1R9JQ@1224|Proteobacteria,2U3WR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3256686_6	460265.Mnod_6630	1.976e-06	58.0	COG2372@1|root,COG2372@2|Bacteria,1N8SS@1224|Proteobacteria,2UFW5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Copper resistance protein	copC	-	-	ko:K07156	-	-	-	-	ko00000,ko02000	9.B.62.2	-	-	CopC
TLS1_k127_3256686_5	946235.CAER01000041_gene2127	3.078e-28	127.0	COG0640@1|root,COG0640@2|Bacteria,1TSRQ@1239|Firmicutes,4HBXM@91061|Bacilli,23JBT@182709|Oceanobacillus	91061|Bacilli	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
TLS1_k127_3256686_1	861299.J421_0916	1.118e-142	467.0	COG0612@1|root,COG0612@2|Bacteria,1ZSVK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS1_k127_3256686_2	861299.J421_0915	2.367e-88	314.0	COG0612@1|root,COG0612@2|Bacteria,1ZT9J@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS1_k127_3285265_0	1298863.AUEP01000008_gene1246	4.078e-259	807.0	COG1233@1|root,COG1233@2|Bacteria,2GMUC@201174|Actinobacteria,4DTJJ@85009|Propionibacteriales	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
TLS1_k127_3285265_2	1128421.JAGA01000003_gene2771	1.353e-151	492.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
TLS1_k127_3285265_5	2074.JNYD01000001_gene6039	7.939e-91	308.0	COG1175@1|root,COG1175@2|Bacteria,2I8UD@201174|Actinobacteria,4E2H5@85010|Pseudonocardiales	201174|Actinobacteria	G	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS1_k127_3285265_6	1128421.JAGA01000003_gene2769	1.486e-90	315.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS1_k127_3285265_3	926550.CLDAP_37870	5.275e-129	422.0	COG3842@1|root,COG3842@2|Bacteria,2G5X9@200795|Chloroflexi	2|Bacteria	P	PFAM ABC transporter related	-	GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015169,GO:0015399,GO:0015405,GO:0015430,GO:0015605,GO:0015711,GO:0015748,GO:0015794,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0034220,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0098656,GO:1901264,GO:1901505	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
TLS1_k127_3285265_4	1128421.JAGA01000003_gene2767	7.471e-91	322.0	COG3538@1|root,COG3538@2|Bacteria	2|Bacteria	G	Metal-independent alpha-mannosidase (GH125)	-	-	-	ko:K09704	-	-	-	-	ko00000	-	-	-	Glyco_hydro_125
TLS1_k127_3285265_1	309801.trd_1011	9.835e-167	542.0	COG4962@1|root,COG4962@2|Bacteria,2G68E@200795|Chloroflexi,27XTR@189775|Thermomicrobia	189775|Thermomicrobia	U	Type II/IV secretion system protein	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
TLS1_k127_3396_16	88036.EFJ34215	2.32e-56	207.0	COG0179@1|root,KOG1535@2759|Eukaryota,37V52@33090|Viridiplantae,3GKCH@35493|Streptophyta	35493|Streptophyta	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
TLS1_k127_3396_18	416348.Hlac_0915	1.456e-44	181.0	COG1402@1|root,arCOG04536@2157|Archaea,2XTQE@28890|Euryarchaeota,23V30@183963|Halobacteria	183963|Halobacteria	H	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
TLS1_k127_3396_14	512565.AMIS_77200	2.207e-69	249.0	COG1820@1|root,COG1820@2|Bacteria,2GK1E@201174|Actinobacteria,4D9GP@85008|Micromonosporales	201174|Actinobacteria	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	nagA	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
TLS1_k127_3396_17	35754.JNYJ01000031_gene6985	6.397e-49	190.0	COG2188@1|root,COG2188@2|Bacteria,2IK3E@201174|Actinobacteria,4DDPG@85008|Micromonosporales	201174|Actinobacteria	K	UTRA	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
TLS1_k127_3396_15	357808.RoseRS_2512	1.699e-59	229.0	COG1940@1|root,COG1940@2|Bacteria,2G6I0@200795|Chloroflexi,375NG@32061|Chloroflexia	32061|Chloroflexia	GK	PFAM ROK family protein	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
TLS1_k127_3396_11	1082933.MEA186_20774	5.472e-90	322.0	COG1172@1|root,COG1172@2|Bacteria,1PRXF@1224|Proteobacteria,2TV5I@28211|Alphaproteobacteria,43RE4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
TLS1_k127_3396_9	536019.Mesop_3291	9.59e-99	343.0	COG1172@1|root,COG1172@2|Bacteria,1MVKQ@1224|Proteobacteria,2TTT3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
TLS1_k127_3396_1	1297569.MESS2_1340010	3.79e-191	611.0	COG1129@1|root,COG1129@2|Bacteria,1R8D8@1224|Proteobacteria,2U4HH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	ABC-type sugar transport system, ATPase component	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
TLS1_k127_3396_8	314256.OG2516_05458	2.448e-101	346.0	COG1879@1|root,COG1879@2|Bacteria,1MXJS@1224|Proteobacteria,2TTHJ@28211|Alphaproteobacteria,2PEUM@252301|Oceanicola	28211|Alphaproteobacteria	G	Periplasmic binding protein domain	ytfQ	GO:0003674,GO:0005215,GO:0005488,GO:0005534,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0015144,GO:0015145,GO:0015749,GO:0015757,GO:0016020,GO:0016021,GO:0022857,GO:0030246,GO:0030288,GO:0030313,GO:0031224,GO:0031975,GO:0034219,GO:0036094,GO:0042597,GO:0044425,GO:0044464,GO:0048029,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944	-	ko:K02058,ko:K10439,ko:K17213	ko02010,ko02030,map02010,map02030	M00212,M00221,M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
TLS1_k127_3396_12	1968.JOEV01000003_gene3296	2.156e-89	301.0	COG4821@1|root,COG4821@2|Bacteria,2GY6Q@201174|Actinobacteria	201174|Actinobacteria	S	protein containing SIS (Sugar isomerase) phosphosugar binding domain	-	-	-	-	-	-	-	-	-	-	-	-	SIS_2
TLS1_k127_3396_13	926560.KE387023_gene1711	1.024e-83	284.0	COG0274@1|root,COG0274@2|Bacteria,1WMRB@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	DeoC/LacD family aldolase	-	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
TLS1_k127_3396_3	1040986.ATYO01000002_gene4218	4.399e-147	474.0	COG1082@1|root,COG1082@2|Bacteria,1PKSR@1224|Proteobacteria,2U1RX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	AP endonuclease family 2 C terminus	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
TLS1_k127_3396_4	357808.RoseRS_1084	7.93e-144	467.0	COG0673@1|root,COG0673@2|Bacteria,2G6V1@200795|Chloroflexi,375S4@32061|Chloroflexia	32061|Chloroflexia	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS1_k127_3396_5	1169161.KB897727_gene895	4.353e-127	420.0	COG1609@1|root,COG1609@2|Bacteria,2GJRG@201174|Actinobacteria	201174|Actinobacteria	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K17640	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
TLS1_k127_3396_6	28444.JODQ01000007_gene5693	3.287e-125	418.0	COG1653@1|root,COG1653@2|Bacteria,2GP9H@201174|Actinobacteria,4EHAS@85012|Streptosporangiales	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8
TLS1_k127_3396_7	1089545.KB913037_gene9428	2.02e-107	357.0	COG1175@1|root,COG1175@2|Bacteria,2GKJI@201174|Actinobacteria,4DZ1C@85010|Pseudonocardiales	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025,ko:K10118	ko02010,map02010	M00196,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.28	-	-	BPD_transp_1
TLS1_k127_3396_10	1246995.AFR_14785	2.83e-95	325.0	COG0395@1|root,COG0395@2|Bacteria,2GNQW@201174|Actinobacteria,4D8QX@85008|Micromonosporales	201174|Actinobacteria	P	ABC-type sugar transport system, permease component	-	-	-	ko:K02026,ko:K10119,ko:K17243	ko02010,map02010	M00196,M00207,M00600	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.28,3.A.1.1.39	-	-	BPD_transp_1
TLS1_k127_3396_0	935948.KE386494_gene334	9.371e-224	728.0	COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia,42FMZ@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM glycoside hydrolase, family 3 domain protein	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
TLS1_k127_3396_2	926550.CLDAP_33960	5.638e-184	588.0	COG0673@1|root,COG0673@2|Bacteria,2G7UY@200795|Chloroflexi	200795|Chloroflexi	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS1_k127_3396_19	383372.Rcas_2758	2.239e-21	97.0	COG0620@1|root,COG0620@2|Bacteria,2G7J6@200795|Chloroflexi,377RE@32061|Chloroflexia	32061|Chloroflexia	H	PFAM Methionine synthase, vitamin-B12 independent	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
TLS1_k127_3410230_5	367299.JOEE01000001_gene1484	1.069e-36	160.0	COG0308@1|root,COG0308@2|Bacteria,2ID1N@201174|Actinobacteria,4FIRF@85021|Intrasporangiaceae	201174|Actinobacteria	E	aminopeptidase N	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3410230_4	367299.JOEE01000001_gene1484	1.465e-40	173.0	COG0308@1|root,COG0308@2|Bacteria,2ID1N@201174|Actinobacteria,4FIRF@85021|Intrasporangiaceae	201174|Actinobacteria	E	aminopeptidase N	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3410230_0	1521187.JPIM01000153_gene945	2.987e-151	491.0	COG0448@1|root,COG0448@2|Bacteria,2G66Q@200795|Chloroflexi,374V0@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
TLS1_k127_3410230_7	1416752.AYME01000007_gene1115	7.836e-21	107.0	COG0739@1|root,COG0739@2|Bacteria,2GXEC@201174|Actinobacteria,4FM7P@85023|Microbacteriaceae	201174|Actinobacteria	M	Peptidase family M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
TLS1_k127_3410230_8	1380347.JNII01000008_gene4384	1.802e-12	76.0	COG1989@1|root,COG1989@2|Bacteria,2GJ7K@201174|Actinobacteria,4ESYI@85013|Frankiales	201174|Actinobacteria	NOU	peptidase A24A prepilin type IV	-	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	Peptidase_A24
TLS1_k127_3410230_1	234267.Acid_1288	5.202e-88	310.0	COG0260@1|root,COG0260@2|Bacteria,3Y33T@57723|Acidobacteria	57723|Acidobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
TLS1_k127_3410230_3	574087.Acear_0299	1.542e-58	224.0	COG1816@1|root,COG1816@2|Bacteria,1U44B@1239|Firmicutes,247KD@186801|Clostridia,3WC1G@53433|Halanaerobiales	186801|Clostridia	F	Adenosine/AMP deaminase	add	-	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS13960	A_deaminase
TLS1_k127_3410230_2	1499967.BAYZ01000013_gene6452	1.917e-80	276.0	COG2227@1|root,COG2227@2|Bacteria,2NRF7@2323|unclassified Bacteria	2|Bacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS1_k127_3410230_9	1537715.JQFJ01000002_gene458	0.0001486	52.0	COG1396@1|root,COG3800@1|root,COG1396@2|Bacteria,COG3800@2|Bacteria,1MU50@1224|Proteobacteria,2TRKE@28211|Alphaproteobacteria,2K126@204457|Sphingomonadales	204457|Sphingomonadales	K	Transcriptional regulator	-	-	-	ko:K07110	-	-	-	-	ko00000,ko03000	-	-	-	DUF2083,HTH_19,HTH_3,HTH_31,Peptidase_M78
TLS1_k127_3410230_6	292459.STH2305	6.866e-24	106.0	COG0563@1|root,COG0563@2|Bacteria	2|Bacteria	F	adenylate kinase activity	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AAA_33,ADK,ADK_lid,SKI
TLS1_k127_3410983_5	190650.CC_1991	1.407e-06	53.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2TQYG@28211|Alphaproteobacteria,2KF0Q@204458|Caulobacterales	204458|Caulobacterales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
TLS1_k127_3410983_1	309801.trd_1375	1.443e-124	411.0	COG0462@1|root,COG0462@2|Bacteria,2G5T8@200795|Chloroflexi,27Y4E@189775|Thermomicrobia	189775|Thermomicrobia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
TLS1_k127_3410983_0	479434.Sthe_1721	5.676e-293	921.0	COG0188@1|root,COG0188@2|Bacteria,2G5Q2@200795|Chloroflexi,27Y2U@189775|Thermomicrobia	189775|Thermomicrobia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
TLS1_k127_3410983_4	1306406.ASHX01000001_gene2679	1.409e-09	70.0	COG4912@1|root,COG4912@2|Bacteria,2ID3C@201174|Actinobacteria	201174|Actinobacteria	L	DNA alkylation repair	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
TLS1_k127_3410983_3	1192034.CAP_1486	6.323e-30	126.0	COG2050@1|root,COG2050@2|Bacteria,1N8F8@1224|Proteobacteria,42V78@68525|delta/epsilon subdivisions,2WRBA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS1_k127_3410983_2	635013.TherJR_0008	2.972e-89	298.0	COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,248AV@186801|Clostridia,260WQ@186807|Peptococcaceae	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
TLS1_k127_3471781_4	243164.DET0444	3.504e-76	263.0	COG0217@1|root,COG0217@2|Bacteria,2G6AI@200795|Chloroflexi,34CQY@301297|Dehalococcoidia	301297|Dehalococcoidia	K	regulation of RNA biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
TLS1_k127_3471781_5	871963.Desdi_2527	3.381e-48	186.0	COG0817@1|root,COG0817@2|Bacteria,1V3N9@1239|Firmicutes,24HMI@186801|Clostridia,261I9@186807|Peptococcaceae	186801|Clostridia	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
TLS1_k127_3471781_6	1128421.JAGA01000002_gene404	1.035e-32	138.0	COG0632@1|root,COG0632@2|Bacteria,2NPR6@2323|unclassified Bacteria	2|Bacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
TLS1_k127_3471781_3	1150864.MILUP08_43370	2.759e-108	369.0	COG1541@1|root,COG1541@2|Bacteria,2HVC4@201174|Actinobacteria,4DH06@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	-
TLS1_k127_3471781_7	316067.Geob_1650	2.796e-28	120.0	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,43ABU@68525|delta/epsilon subdivisions,2WVAV@28221|Deltaproteobacteria,43UYX@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
TLS1_k127_3471781_1	545693.BMQ_4643	1.745e-123	406.0	COG2255@1|root,COG2255@2|Bacteria,1TR47@1239|Firmicutes,4HBMW@91061|Bacilli,1ZC5A@1386|Bacillus	91061|Bacilli	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
TLS1_k127_3471781_9	383372.Rcas_1373	2.055e-15	78.0	2A4D2@1|root,30SYV@2|Bacteria,2G7DH@200795|Chloroflexi,377NP@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function (DUF2905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2905
TLS1_k127_3471781_2	1128421.JAGA01000002_gene1582	2.879e-109	387.0	COG0343@1|root,COG0343@2|Bacteria,2NNQS@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0008479,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	iECW_1372.ECW_m0475,iWFL_1372.ECW_m0475	TGT
TLS1_k127_3471781_0	138119.DSY1943	9.629e-148	475.0	COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,247SF@186801|Clostridia,260U5@186807|Peptococcaceae	186801|Clostridia	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
TLS1_k127_3471781_8	1232436.CAPF01000014_gene781	5.018e-16	78.0	COG0468@1|root,COG0468@2|Bacteria,2GJ4P@201174|Actinobacteria,4CUYM@84998|Coriobacteriia	84998|Coriobacteriia	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
TLS1_k127_3597951_1	1382306.JNIM01000001_gene766	1.877e-133	446.0	COG0166@1|root,COG0166@2|Bacteria,2G67J@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the GPI family	pgi	-	2.2.1.2,5.3.1.9	ko:K01810,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI,TAL_FSA
TLS1_k127_3597951_3	330214.NIDE2204	1.182e-117	388.0	COG1023@1|root,COG1023@2|Bacteria	2|Bacteria	G	D-gluconate metabolic process	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
TLS1_k127_3597951_0	1382356.JQMP01000003_gene1987	6.423e-200	639.0	COG0364@1|root,COG0364@2|Bacteria,2G5MB@200795|Chloroflexi,27XRX@189775|Thermomicrobia	189775|Thermomicrobia	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
TLS1_k127_3597951_11	324602.Caur_0502	1.307e-35	152.0	COG3429@1|root,COG3429@2|Bacteria,2G6ZV@200795|Chloroflexi,375YF@32061|Chloroflexia	32061|Chloroflexia	G	Glucose-6-phosphate dehydrogenase subunit	-	-	-	-	-	-	-	-	-	-	-	-	OpcA_G6PD_assem
TLS1_k127_3597951_12	1128421.JAGA01000002_gene1196	2.671e-34	152.0	COG0363@1|root,COG0363@2|Bacteria,2NPBM@2323|unclassified Bacteria	2|Bacteria	G	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	pgl	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
TLS1_k127_3597951_8	1122138.AQUZ01000019_gene8185	2.016e-50	204.0	COG2267@1|root,COG2267@2|Bacteria,2GJUE@201174|Actinobacteria,4DQUJ@85009|Propionibacteriales	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS1_k127_3597951_13	290398.Csal_2587	2.378e-11	66.0	COG2261@1|root,COG2261@2|Bacteria,1N72W@1224|Proteobacteria,1S8YP@1236|Gammaproteobacteria,1XMJZ@135619|Oceanospirillales	135619|Oceanospirillales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
TLS1_k127_3597951_4	485913.Krac_8721	4.506e-101	342.0	COG0372@1|root,COG0372@2|Bacteria,2G7NR@200795|Chloroflexi	200795|Chloroflexi	H	Belongs to the citrate synthase family	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
TLS1_k127_3597951_5	690850.Desaf_1729	1.471e-98	329.0	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,42M0S@68525|delta/epsilon subdivisions,2WITR@28221|Deltaproteobacteria,2M7ZW@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM ABC transporter related	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
TLS1_k127_3597951_7	1405.DJ92_3242	1.905e-54	203.0	COG0834@1|root,COG0834@2|Bacteria,1TT11@1239|Firmicutes,4HAHV@91061|Bacilli,1ZCGF@1386|Bacillus	91061|Bacilli	ET	Belongs to the bacterial solute-binding protein 3 family	glnH	-	-	ko:K09969,ko:K10039	ko02010,map02010	M00228,M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	SBP_bac_3
TLS1_k127_3597951_9	634956.Geoth_2334	5.388e-39	154.0	COG0765@1|root,COG0765@2|Bacteria,1TQ5K@1239|Firmicutes,4HFBH@91061|Bacilli,1WET1@129337|Geobacillus	91061|Bacilli	P	Binding-protein-dependent transport system inner membrane component	glnM	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015318,GO:0015711,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1903825,GO:1905039	-	ko:K10040	ko02010,map02010	M00228	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
TLS1_k127_3597951_10	1120950.KB892756_gene6699	1.768e-37	161.0	COG0765@1|root,COG0765@2|Bacteria,2GNBH@201174|Actinobacteria,4DQVW@85009|Propionibacteriales	201174|Actinobacteria	E	Binding-protein-dependent transport system inner membrane component	gluD	-	-	ko:K10007	ko02010,map02010	M00233	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.9	-	-	BPD_transp_1
TLS1_k127_3597951_2	101510.RHA1_ro04494	1.526e-120	408.0	COG2072@1|root,COG2072@2|Bacteria,2GM3S@201174|Actinobacteria,4FXC2@85025|Nocardiaceae	201174|Actinobacteria	P	L-lysine 6-monooxygenase (NADPH-requiring)	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
TLS1_k127_3597951_6	1283283.ATXA01000008_gene2996	7.276e-94	316.0	COG2197@1|root,COG2197@2|Bacteria,2GKXJ@201174|Actinobacteria	201174|Actinobacteria	K	PFAM regulatory protein LuxR	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS1_k127_3605748_2	867845.KI911784_gene431	1.213e-109	368.0	COG0173@1|root,COG0173@2|Bacteria,2G5RX@200795|Chloroflexi,374WK@32061|Chloroflexia	32061|Chloroflexia	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
TLS1_k127_3605748_3	644966.Tmar_1241	3.848e-96	327.0	COG0124@1|root,COG0124@2|Bacteria,1TP3D@1239|Firmicutes,24852@186801|Clostridia,3WCNJ@538999|Clostridiales incertae sedis	186801|Clostridia	J	Histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
TLS1_k127_3605748_0	1121468.AUBR01000003_gene633	3.395e-243	773.0	COG0317@1|root,COG0317@2|Bacteria,1TNYZ@1239|Firmicutes,2489A@186801|Clostridia,42F3U@68295|Thermoanaerobacterales	186801|Clostridia	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS16615	ACT_4,HD_4,RelA_SpoT,TGS
TLS1_k127_3605748_1	357808.RoseRS_0794	5.084e-112	387.0	COG0769@1|root,COG0769@2|Bacteria,2G5U3@200795|Chloroflexi,375DT@32061|Chloroflexia	32061|Chloroflexia	M	Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS1_k127_3605748_5	1507.HMPREF0262_01516	1.158e-16	94.0	COG2348@1|root,COG2348@2|Bacteria,1TRZU@1239|Firmicutes,24AU8@186801|Clostridia,36HK6@31979|Clostridiaceae	186801|Clostridia	V	FemAB family	femX	-	2.3.2.10,2.3.2.16	ko:K05363,ko:K11693	ko00550,ko01100,map00550,map01100	-	R08776,R08779	RC00055,RC00096	ko00000,ko00001,ko01000,ko01011	-	-	-	FemAB
TLS1_k127_3605748_4	926550.CLDAP_31480	6.356e-46	182.0	COG2348@1|root,COG2348@2|Bacteria,2G6KK@200795|Chloroflexi	200795|Chloroflexi	V	PFAM Methicillin resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	FemAB
TLS1_k127_3635136_2	1040986.ATYO01000001_gene2116	1.212e-13	81.0	COG1266@1|root,COG1266@2|Bacteria,1NJ72@1224|Proteobacteria,2VERN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
TLS1_k127_3635136_4	561175.KB894094_gene2064	2.276e-08	67.0	COG3147@1|root,COG3147@2|Bacteria,2ID4R@201174|Actinobacteria,4EHHH@85012|Streptosporangiales	201174|Actinobacteria	S	Non-essential cell division protein that could be required for efficient cell constriction	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3635136_0	391037.Sare_2110	1.257e-72	251.0	COG4912@1|root,COG4912@2|Bacteria,2ID3C@201174|Actinobacteria	201174|Actinobacteria	L	DNA alkylation repair	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
TLS1_k127_3635136_3	521096.Tpau_0479	1.402e-08	57.0	COG0640@1|root,COG0640@2|Bacteria,2IQ55@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS1_k127_3661521_2	404589.Anae109_1412	4.128e-59	208.0	COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,42MZY@68525|delta/epsilon subdivisions,2WJWT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
TLS1_k127_3661521_3	1313421.JHBV01000007_gene4258	7.222e-11	78.0	COG1572@1|root,COG3291@1|root,COG1572@2|Bacteria,COG3291@2|Bacteria,4NN8K@976|Bacteroidetes	976|Bacteroidetes	S	Domain of unknown function (DUF1735)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1735,Laminin_G_3
TLS1_k127_3661521_1	1122182.KB903813_gene2669	3.85e-71	277.0	COG1409@1|root,COG1409@2|Bacteria,2IM97@201174|Actinobacteria,4D9VR@85008|Micromonosporales	201174|Actinobacteria	S	Calcineurin-like phosphoesterase	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Metallophos
TLS1_k127_3661521_0	926562.Oweho_2792	2.37e-204	704.0	COG1409@1|root,COG1409@2|Bacteria,4NEQ8@976|Bacteroidetes,1I0MD@117743|Flavobacteriia	976|Bacteroidetes	S	Ser Thr phosphatase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
TLS1_k127_367421_0	1111479.AXAR01000016_gene3086	4.579e-144	470.0	COG1418@1|root,COG1418@2|Bacteria,1TP48@1239|Firmicutes,4HC9J@91061|Bacilli,277VR@186823|Alicyclobacillaceae	91061|Bacilli	S	Endoribonuclease that initiates mRNA decay	rny	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
TLS1_k127_367421_1	1122611.KB903957_gene71	1.147e-59	216.0	COG0860@1|root,COG0860@2|Bacteria,2GPA9@201174|Actinobacteria,4EJA6@85012|Streptosporangiales	201174|Actinobacteria	M	Ami_3	-	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008745,GO:0016787,GO:0016810,GO:0016811,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0061783	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3
TLS1_k127_367421_2	502025.Hoch_5114	2.421e-59	214.0	28XBK@1|root,2ZJ9G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_367421_3	1206729.BAFZ01000077_gene1587	2.747e-16	84.0	COG2137@1|root,COG2137@2|Bacteria,2GMRF@201174|Actinobacteria,4G0EH@85025|Nocardiaceae	201174|Actinobacteria	S	Modulates RecA activity	recX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
TLS1_k127_3824622_9	1122182.KB903813_gene2648	3.212e-06	54.0	COG0836@1|root,COG0836@2|Bacteria,2GIRM@201174|Actinobacteria,4D91K@85008|Micromonosporales	201174|Actinobacteria	M	Mannose-1-phosphate guanylyltransferase	manC	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
TLS1_k127_3824622_1	1128421.JAGA01000004_gene2629	1.646e-119	406.0	COG1109@1|root,COG1109@2|Bacteria,2NNTH@2323|unclassified Bacteria	2|Bacteria	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	pgm	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS1_k127_3824622_6	1278073.MYSTI_04470	3.535e-34	141.0	COG0662@1|root,COG0662@2|Bacteria,1NADF@1224|Proteobacteria,4383M@68525|delta/epsilon subdivisions,2X9WE@28221|Deltaproteobacteria,2YVKF@29|Myxococcales	28221|Deltaproteobacteria	G	Mannose-6-phosphate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS1_k127_3824622_8	243164.DET0018	3.319e-25	109.0	2EAGR@1|root,334K0@2|Bacteria,2G730@200795|Chloroflexi,34DFF@301297|Dehalococcoidia	301297|Dehalococcoidia	S	PFAM zinc finger, SWIM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3824622_4	926569.ANT_02530	2.326e-52	199.0	COG0614@1|root,COG0614@2|Bacteria,2G6TS@200795|Chloroflexi	200795|Chloroflexi	P	periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
TLS1_k127_3824622_2	255470.cbdbA635	1.573e-75	267.0	COG0609@1|root,COG0609@2|Bacteria,2G6E8@200795|Chloroflexi,34CYV@301297|Dehalococcoidia	301297|Dehalococcoidia	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
TLS1_k127_3824622_3	292459.STH1933	1.137e-58	226.0	COG1120@1|root,COG1120@2|Bacteria,1TP2Q@1239|Firmicutes,2492Z@186801|Clostridia	186801|Clostridia	HP	Abc transporter	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
TLS1_k127_3824622_7	1333523.L593_10670	1.056e-28	134.0	COG0010@1|root,arCOG01700@2157|Archaea,2XU8D@28890|Euryarchaeota,23U2W@183963|Halobacteria	183963|Halobacteria	E	Belongs to the arginase family	arg1	-	3.5.3.1	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00134	R00551	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
TLS1_k127_3824622_0	246197.MXAN_1407	4.204e-136	458.0	COG0436@1|root,COG0436@2|Bacteria,1MX43@1224|Proteobacteria,42Q5H@68525|delta/epsilon subdivisions,2WKW4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Aminotransferase, class I	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
TLS1_k127_3824622_5	526225.Gobs_2148	1.31e-36	142.0	COG0662@1|root,COG0662@2|Bacteria,2II1B@201174|Actinobacteria	201174|Actinobacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS1_k127_3837492_25	324057.Pjdr2_0085	6.868e-24	116.0	COG4346@1|root,COG5650@1|root,COG4346@2|Bacteria,COG5650@2|Bacteria,1TQVD@1239|Firmicutes,4HEQ0@91061|Bacilli,276JI@186822|Paenibacillaceae	91061|Bacilli	O	integral membrane protein	-	-	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	GT87,PMT_2
TLS1_k127_3837492_27	1192034.CAP_6141	1.099e-20	107.0	COG1807@1|root,COG1807@2|Bacteria,1Q2FK@1224|Proteobacteria,4381I@68525|delta/epsilon subdivisions,2X3BM@28221|Deltaproteobacteria,2YUUG@29|Myxococcales	28221|Deltaproteobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3837492_23	42256.RradSPS_1227	2.479e-27	130.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723,PMT_2
TLS1_k127_3837492_12	1382356.JQMP01000004_gene418	4.579e-54	216.0	COG0463@1|root,COG0463@2|Bacteria,2G6TA@200795|Chloroflexi,27XT0@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS1_k127_3837492_17	765420.OSCT_1025	2.179e-40	159.0	COG1259@1|root,COG1259@2|Bacteria,2G6P6@200795|Chloroflexi,3772Y@32061|Chloroflexia	32061|Chloroflexia	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
TLS1_k127_3837492_14	671143.DAMO_2064	9.635e-53	214.0	COG0705@1|root,COG0705@2|Bacteria,2NPGI@2323|unclassified Bacteria	2|Bacteria	S	(Rhomboid) family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
TLS1_k127_3837492_33	1382356.JQMP01000004_gene409	4.694e-05	57.0	COG0631@1|root,COG0631@2|Bacteria,2G6R4@200795|Chloroflexi,27XZK@189775|Thermomicrobia	189775|Thermomicrobia	T	Serine/threonine phosphatases, family 2C, catalytic domain	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C
TLS1_k127_3837492_11	1203076.CAKF01000020_gene1597	5.702e-62	237.0	COG1195@1|root,COG1195@2|Bacteria,1TP9U@1239|Firmicutes,4HA0W@91061|Bacilli,3F3Q1@33958|Lactobacillaceae	91061|Bacilli	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
TLS1_k127_3837492_6	525904.Tter_0993	8.528e-99	334.0	COG0592@1|root,COG0592@2|Bacteria,2NP7D@2323|unclassified Bacteria	2|Bacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
TLS1_k127_3837492_2	1128421.JAGA01000002_gene1335	7.935e-149	489.0	COG0593@1|root,COG0593@2|Bacteria,2NNTK@2323|unclassified Bacteria	2|Bacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
TLS1_k127_3837492_31	471855.Shel_28540	1.505e-11	67.0	COG0230@1|root,COG0230@2|Bacteria,2GQFY@201174|Actinobacteria,4CWG7@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
TLS1_k127_3837492_30	383372.Rcas_1424	4.047e-12	76.0	COG0594@1|root,COG0594@2|Bacteria,2G76W@200795|Chloroflexi,375ZH@32061|Chloroflexia	32061|Chloroflexia	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
TLS1_k127_3837492_28	32049.SYNPCC7002_A1175	4.446e-20	97.0	COG0759@1|root,COG0759@2|Bacteria,1G90B@1117|Cyanobacteria,1H14U@1129|Synechococcus	1117|Cyanobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
TLS1_k127_3837492_26	1511.CLOST_2587	9.854e-23	113.0	COG0706@1|root,COG0706@2|Bacteria,1TQ0J@1239|Firmicutes,247V9@186801|Clostridia,25RE0@186804|Peptostreptococcaceae	186801|Clostridia	U	60Kd inner membrane protein	oxaA	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
TLS1_k127_3837492_24	926550.CLDAP_04280	3.765e-27	129.0	COG1847@1|root,COG1847@2|Bacteria,2G6XH@200795|Chloroflexi	200795|Chloroflexi	S	PFAM single-stranded nucleic acid binding R3H domain protein	-	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
TLS1_k127_3837492_20	1381751.JAJB01000009_gene2490	2.306e-31	141.0	COG2720@1|root,COG2720@2|Bacteria,2GISH@201174|Actinobacteria,4F9F8@85019|Brevibacteriaceae	201174|Actinobacteria	V	VanW like protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_4,VanW
TLS1_k127_3837492_21	1035308.AQYY01000001_gene1662	1.099e-29	125.0	COG1733@1|root,COG1733@2|Bacteria	2|Bacteria	K	regulation of RNA biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
TLS1_k127_3837492_10	1035308.AQYY01000001_gene1663	1.671e-64	239.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	hhoA	GO:0003674,GO:0005488,GO:0005515,GO:0042802	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
TLS1_k127_3837492_5	1121946.AUAX01000012_gene6615	1.106e-104	351.0	COG0265@1|root,COG0265@2|Bacteria,2GNZT@201174|Actinobacteria,4DCKP@85008|Micromonosporales	201174|Actinobacteria	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
TLS1_k127_3837492_15	525904.Tter_2554	4.736e-48	180.0	COG4635@1|root,COG4635@2|Bacteria	2|Bacteria	CH	menaquinone-dependent protoporphyrinogen oxidase activity	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
TLS1_k127_3837492_34	1192124.LIG30_2998	7.967e-05	53.0	arCOG10456@1|root,2ZA6T@2|Bacteria,1R4VS@1224|Proteobacteria,2VQRB@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3837492_22	525904.Tter_1733	8.959e-29	126.0	COG1651@1|root,COG1651@2|Bacteria,2NPXE@2323|unclassified Bacteria	2|Bacteria	O	Thioredoxin	bdbD	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
TLS1_k127_3837492_29	324602.Caur_0293	1.432e-14	80.0	COG0526@1|root,COG4243@1|root,COG0526@2|Bacteria,COG4243@2|Bacteria,2G9QC@200795|Chloroflexi,3764Y@32061|Chloroflexia	32061|Chloroflexia	CO	PFAM Vitamin K epoxide reductase	-	-	-	-	-	-	-	-	-	-	-	-	VKOR
TLS1_k127_3837492_16	1123023.JIAI01000002_gene5802	7.847e-45	170.0	COG0831@1|root,COG0832@1|root,COG0831@2|Bacteria,COG0832@2|Bacteria,2IKNA@201174|Actinobacteria,4E4HR@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the urease gamma subunit family	-	-	3.5.1.5	ko:K14048	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Urease_beta,Urease_gamma
TLS1_k127_3837492_3	1123320.KB889673_gene3632	5.146e-147	484.0	COG0804@1|root,COG0804@2|Bacteria,2GM7X@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family	ureC	-	3.5.1.5	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Urease_alpha
TLS1_k127_3837492_7	42256.RradSPS_0432	3.624e-91	313.0	COG2141@1|root,COG2141@2|Bacteria,2HGTQ@201174|Actinobacteria,4CQ6X@84995|Rubrobacteria	84995|Rubrobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS1_k127_3837492_1	234267.Acid_6579	2.521e-158	516.0	COG3938@1|root,COG3938@2|Bacteria,3Y6TR@57723|Acidobacteria	57723|Acidobacteria	E	Proline racemase	-	-	5.1.1.4,5.1.1.8	ko:K01777,ko:K12658	ko00330,ko01100,map00330,map01100	-	R01255,R03296	RC00479	ko00000,ko00001,ko01000	-	-	-	Pro_racemase
TLS1_k127_3837492_13	1121468.AUBR01000008_gene2068	5.316e-54	193.0	COG0691@1|root,COG0691@2|Bacteria,1V3IJ@1239|Firmicutes,24HD6@186801|Clostridia,42GC6@68295|Thermoanaerobacterales	186801|Clostridia	J	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
TLS1_k127_3837492_8	926569.ANT_12940	9.403e-84	294.0	COG0793@1|root,COG0793@2|Bacteria,2G6HR@200795|Chloroflexi	200795|Chloroflexi	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
TLS1_k127_3837492_19	1089548.KI783301_gene2887	4.573e-33	139.0	COG2177@1|root,COG2177@2|Bacteria,1TPND@1239|Firmicutes,4HA5A@91061|Bacilli,3WFE2@539002|Bacillales incertae sedis	91061|Bacilli	D	Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
TLS1_k127_3837492_9	1121430.JMLG01000004_gene965	6.518e-78	269.0	COG2884@1|root,COG2884@2|Bacteria,1TP58@1239|Firmicutes,248HW@186801|Clostridia,25ZZ9@186807|Peptococcaceae	186801|Clostridia	D	TIGRFAM Cell division ATP-binding protein FtsE	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
TLS1_k127_3837492_32	1449347.JQLN01000007_gene1748	4.486e-09	67.0	COG3153@1|root,COG3153@2|Bacteria,2I2Y6@201174|Actinobacteria,2M2JT@2063|Kitasatospora	201174|Actinobacteria	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
TLS1_k127_3837492_4	1444306.JFZC01000036_gene2959	1.326e-112	376.0	COG1186@1|root,COG1186@2|Bacteria,1TPSB@1239|Firmicutes,4H9N2@91061|Bacilli,26NBY@186821|Sporolactobacillaceae	91061|Bacilli	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
TLS1_k127_3837492_18	935863.AWZR01000004_gene441	1.903e-39	157.0	COG1434@1|root,COG1434@2|Bacteria,1N0Q9@1224|Proteobacteria,1S98Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
TLS1_k127_3837492_0	1089553.Tph_c06470	1.826e-201	647.0	COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,247N2@186801|Clostridia,42ETW@68295|Thermoanaerobacterales	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
TLS1_k127_3846699_6	263358.VAB18032_26806	3.992e-13	72.0	COG0772@1|root,COG0772@2|Bacteria,2GKXP@201174|Actinobacteria,4D8GC@85008|Micromonosporales	201174|Actinobacteria	D	Belongs to the SEDS family	ftsW	GO:0008150,GO:0040007	2.4.1.227	ko:K02563,ko:K03588	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011,ko02000,ko03036	2.A.103.1	GT28	-	FTSW_RODA_SPOVE
TLS1_k127_3846699_4	1051632.TPY_3476	1.094e-32	135.0	COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,24894@186801|Clostridia,3WCI1@538999|Clostridiales incertae sedis	186801|Clostridia	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
TLS1_k127_3846699_2	1121422.AUMW01000005_gene587	4.109e-58	218.0	COG0707@1|root,COG0707@2|Bacteria,1TQFT@1239|Firmicutes,248IA@186801|Clostridia,260TT@186807|Peptococcaceae	186801|Clostridia	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
TLS1_k127_3846699_3	658655.HMPREF0988_00925	1.275e-55	218.0	COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,247IU@186801|Clostridia,27J9M@186928|unclassified Lachnospiraceae	186801|Clostridia	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
TLS1_k127_3846699_1	1007103.AFHW01000167_gene876	6.223e-61	230.0	COG1181@1|root,COG1181@2|Bacteria,1TP2Y@1239|Firmicutes,4H9KB@91061|Bacilli,26SM0@186822|Paenibacillaceae	91061|Bacilli	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
TLS1_k127_3846699_7	485913.Krac_8644	1.736e-08	67.0	COG1589@1|root,COG1589@2|Bacteria,2G7FV@200795|Chloroflexi	200795|Chloroflexi	D	Cell division protein FtsQ	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
TLS1_k127_3846699_5	316274.Haur_3504	2.473e-27	114.0	COG3856@1|root,COG3856@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1290)	sbp	-	-	-	-	-	-	-	-	-	-	-	DUF1290
TLS1_k127_3846699_0	485913.Krac_8643	8.986e-93	313.0	COG0849@1|root,COG0849@2|Bacteria,2G5V5@200795|Chloroflexi	200795|Chloroflexi	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
TLS1_k127_3850842_8	525904.Tter_1521	6.45e-52	198.0	COG1082@1|root,COG1082@2|Bacteria,2NR3H@2323|unclassified Bacteria	2|Bacteria	G	Xylose isomerase-like TIM barrel	iolE	-	1.1.1.18,1.1.1.369,4.2.1.44	ko:K00010,ko:K03335	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R02782,R05659,R09951	RC00182,RC00782,RC01448	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
TLS1_k127_3850842_2	1380346.JNIH01000034_gene202	3.994e-87	309.0	COG0673@1|root,COG0673@2|Bacteria,2GJCY@201174|Actinobacteria	201174|Actinobacteria	G	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose)	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS1_k127_3850842_4	1121085.AUCI01000001_gene3790	4.807e-77	274.0	COG1653@1|root,COG1653@2|Bacteria,1TQFZ@1239|Firmicutes,4HA0U@91061|Bacilli,1ZCPV@1386|Bacillus	91061|Bacilli	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1
TLS1_k127_3850842_6	1185652.USDA257_c15430	2.153e-60	220.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2TQZY@28211|Alphaproteobacteria,4B6YP@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	permease	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS1_k127_3850842_7	1499967.BAYZ01000009_gene5385	6.957e-58	218.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS1_k127_3850842_11	1155714.KB891988_gene1713	7.232e-16	91.0	COG1082@1|root,COG1082@2|Bacteria,2GSVW@201174|Actinobacteria	201174|Actinobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS1_k127_3850842_5	1123321.KB905821_gene4199	3.121e-66	243.0	COG1609@1|root,COG1609@2|Bacteria,2GNVD@201174|Actinobacteria	201174|Actinobacteria	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
TLS1_k127_3850842_10	765420.OSCT_0241	5.071e-18	95.0	COG0524@1|root,COG0524@2|Bacteria,2G6PQ@200795|Chloroflexi,375MX@32061|Chloroflexia	32061|Chloroflexia	G	PFAM PfkB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
TLS1_k127_3850842_12	479434.Sthe_2170	1.553e-15	83.0	2E4XU@1|root,32ZRS@2|Bacteria,2G9RW@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3850842_3	211114.JOEF01000001_gene7240	3.322e-79	273.0	COG2197@1|root,COG2197@2|Bacteria,2GKBX@201174|Actinobacteria,4E068@85010|Pseudonocardiales	201174|Actinobacteria	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS1_k127_3850842_0	543632.JOJL01000004_gene4132	2.022e-112	392.0	COG4585@1|root,COG4585@2|Bacteria,2HDZV@201174|Actinobacteria,4DB80@85008|Micromonosporales	201174|Actinobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	degS	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS1_k127_3850842_13	290340.AAur_3496	1.17e-08	63.0	2BKAB@1|root,32EQK@2|Bacteria,2GXJB@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3850842_9	469383.Cwoe_5647	9.071e-39	158.0	COG0510@1|root,COG0510@2|Bacteria,2I6IV@201174|Actinobacteria,4CQUA@84995|Rubrobacteria	84995|Rubrobacteria	M	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS1_k127_3850842_1	309801.trd_1799	6.223e-104	349.0	COG0012@1|root,COG0012@2|Bacteria,2G5UY@200795|Chloroflexi,27XGT@189775|Thermomicrobia	189775|Thermomicrobia	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
TLS1_k127_3885268_1	1150399.AQYK01000001_gene1338	1.59e-64	239.0	COG1842@1|root,COG1842@2|Bacteria,2GJGD@201174|Actinobacteria,4FMNN@85023|Microbacteriaceae	201174|Actinobacteria	KT	PspA/IM30 family	-	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
TLS1_k127_3885268_0	67275.JOAP01000012_gene3200	2.048e-69	261.0	COG1512@1|root,COG1512@2|Bacteria,2GMGW@201174|Actinobacteria	201174|Actinobacteria	M	TPM domain	-	-	-	-	-	-	-	-	-	-	-	-	TPM_phosphatase
TLS1_k127_3885268_3	1002804.HBZC1_12100	2.089e-54	209.0	COG0863@1|root,COG0863@2|Bacteria,1R8XS@1224|Proteobacteria	1224|Proteobacteria	L	DNA methylase	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
TLS1_k127_3885268_5	479434.Sthe_0621	1.612e-29	130.0	COG5401@1|root,COG5401@2|Bacteria,2GA61@200795|Chloroflexi,27Y9M@189775|Thermomicrobia	189775|Thermomicrobia	S	Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane,Gmad2
TLS1_k127_3885268_2	1122138.AQUZ01000019_gene8133	6.015e-61	218.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4DP6U@85009|Propionibacteriales	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS1_k127_3885268_4	644966.Tmar_0772	1.201e-48	196.0	COG3850@1|root,COG5002@1|root,COG3850@2|Bacteria,COG5002@2|Bacteria,1TPSK@1239|Firmicutes,24A2N@186801|Clostridia	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS1_k127_3885421_6	644282.Deba_1366	2.149e-96	334.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,42KZJ@68525|delta/epsilon subdivisions,2WJ4U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
TLS1_k127_3885421_0	1128421.JAGA01000002_gene213	5.816e-249	786.0	COG3333@1|root,COG3333@2|Bacteria	2|Bacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
TLS1_k127_3885421_11	1128421.JAGA01000002_gene212	5.703e-39	152.0	2EFUW@1|root,339M2@2|Bacteria	2|Bacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	ko:K07794	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctB
TLS1_k127_3885421_4	324602.Caur_2790	3.88e-122	404.0	COG3181@1|root,COG3181@2|Bacteria,2G8UI@200795|Chloroflexi	200795|Chloroflexi	S	Tripartite tricarboxylate transporter family receptor	-	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
TLS1_k127_3885421_3	1380347.JNII01000005_gene3526	1.159e-136	452.0	COG3290@1|root,COG3290@2|Bacteria,2GIRZ@201174|Actinobacteria	201174|Actinobacteria	T	signal transduction histidine kinase regulating citrate malate metabolism	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS,SPOB_a,sCache_3_2
TLS1_k127_3885421_9	414996.IL38_20610	3.19e-67	242.0	COG4565@1|root,COG4565@2|Bacteria,2GK16@201174|Actinobacteria,409KT@622450|Actinopolysporales	201174|Actinobacteria	KT	cheY-homologous receiver domain	citT	-	-	ko:K02475	-	-	-	-	ko00000,ko02022	-	-	-	HTH_11,HTH_IclR,Response_reg
TLS1_k127_3885421_1	1173028.ANKO01000250_gene2300	2.79e-202	653.0	COG1866@1|root,COG1866@2|Bacteria,1G1KI@1117|Cyanobacteria,1H944@1150|Oscillatoriales	1117|Cyanobacteria	H	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	-	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
TLS1_k127_3885421_5	404589.Anae109_3845	6.034e-113	379.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,42M67@68525|delta/epsilon subdivisions,2WJQX@28221|Deltaproteobacteria,2YTX6@29|Myxococcales	28221|Deltaproteobacteria	E	Cys Met metabolism	metC	-	2.5.1.48,4.4.1.1,4.4.1.11	ko:K01739,ko:K01758,ko:K01761	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338	R00654,R00782,R00999,R01001,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
TLS1_k127_3885421_7	1123023.JIAI01000002_gene5308	8.477e-96	328.0	COG1575@1|root,COG1575@2|Bacteria,2IPQ8@201174|Actinobacteria	201174|Actinobacteria	H	Belongs to the MenA family. Type 1 subfamily	-	-	-	-	-	-	-	-	-	-	-	-	UbiA
TLS1_k127_3885421_2	1283299.AUKG01000001_gene1980	5.6e-150	491.0	COG0031@1|root,COG0031@2|Bacteria,2GIXE@201174|Actinobacteria,4CRTD@84995|Rubrobacteria	84995|Rubrobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
TLS1_k127_3885421_8	1380356.JNIK01000014_gene3482	2.294e-74	273.0	COG0664@1|root,COG0664@2|Bacteria,2I8MP@201174|Actinobacteria	201174|Actinobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,cNMP_binding
TLS1_k127_3885421_13	1380390.JIAT01000014_gene6258	6.52e-16	88.0	COG0204@1|root,COG0240@1|root,COG0204@2|Bacteria,COG0240@2|Bacteria,2GJ6V@201174|Actinobacteria,4CP70@84995|Rubrobacteria	84995|Rubrobacteria	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase,NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
TLS1_k127_3885421_10	82654.Pse7367_2146	4.907e-57	210.0	COG0682@1|root,COG0682@2|Bacteria,1G23G@1117|Cyanobacteria,1HA8N@1150|Oscillatoriales	1117|Cyanobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
TLS1_k127_3885421_12	525904.Tter_0503	5.248e-36	147.0	COG0500@1|root,COG2226@2|Bacteria,2NPGE@2323|unclassified Bacteria	2|Bacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
TLS1_k127_3885421_14	653045.Strvi_2586	0.0004016	49.0	COG5343@1|root,COG5343@2|Bacteria,2I8NI@201174|Actinobacteria	201174|Actinobacteria	K	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK. ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, Rip1), while cytoplasmic proteases finish degrading the regulatory protein, liberating the sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	RskA,zf-HC2
TLS1_k127_3903764_10	1382306.JNIM01000001_gene898	1.356e-88	302.0	COG0173@1|root,COG0173@2|Bacteria,2G5RX@200795|Chloroflexi	200795|Chloroflexi	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
TLS1_k127_3903764_12	1283299.AUKG01000001_gene2057	1.319e-76	280.0	COG0697@1|root,COG0697@2|Bacteria,2I9E0@201174|Actinobacteria,4CPT5@84995|Rubrobacteria	84995|Rubrobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS1_k127_3903764_2	1283299.AUKG01000002_gene3704	2.206e-225	716.0	COG1217@1|root,COG1217@2|Bacteria,2GJUJ@201174|Actinobacteria,4CP9R@84995|Rubrobacteria	84995|Rubrobacteria	T	Elongation factor G C-terminus	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
TLS1_k127_3903764_6	1304880.JAGB01000002_gene1828	2.945e-115	384.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia	186801|Clostridia	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
TLS1_k127_3903764_11	867845.KI911784_gene315	2.588e-87	321.0	COG0482@1|root,COG0482@2|Bacteria,2G64I@200795|Chloroflexi,3751A@32061|Chloroflexia	32061|Chloroflexia	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
TLS1_k127_3903764_5	1246995.AFR_21670	1.448e-123	410.0	COG2182@1|root,COG2182@2|Bacteria,2I2J8@201174|Actinobacteria,4DMJC@85008|Micromonosporales	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
TLS1_k127_3903764_7	1944.JOAZ01000017_gene3515	2.255e-104	347.0	COG1175@1|root,COG1175@2|Bacteria,2GKBJ@201174|Actinobacteria,41BSJ@629295|Streptomyces griseus group	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025,ko:K10118	ko02010,map02010	M00196,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.28	-	-	BPD_transp_1
TLS1_k127_3903764_8	479435.Kfla_5387	1.356e-103	347.0	COG0395@1|root,COG0395@2|Bacteria,2GMTH@201174|Actinobacteria,4DU5W@85009|Propionibacteriales	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026,ko:K05815	ko02010,map02010	M00198,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.3	-	-	BPD_transp_1
TLS1_k127_3903764_4	1380390.JIAT01000013_gene216	1.062e-194	619.0	COG3459@1|root,COG3459@2|Bacteria,2IA66@201174|Actinobacteria,4CS35@84995|Rubrobacteria	84995|Rubrobacteria	G	Protein of unknown function (DUF3131)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3131,Glycoamylase
TLS1_k127_3903764_3	1095767.CAHD01000027_gene1651	1.388e-195	635.0	COG3664@1|root,COG3664@2|Bacteria,2GNYC@201174|Actinobacteria	201174|Actinobacteria	G	PFAM glycoside hydrolase family 39	-	-	3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH43	-	F5_F8_type_C,Glyco_hydro_39
TLS1_k127_3903764_0	622637.KE124774_gene775	5.296e-271	875.0	COG3459@1|root,COG3459@2|Bacteria,1PXDE@1224|Proteobacteria,2U4SV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Glycosyltransferase 36 associated	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_36,Glyco_transf_36
TLS1_k127_3903764_1	264732.Moth_1644	5.026e-231	746.0	COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,248M3@186801|Clostridia,42EUK@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
TLS1_k127_3903764_9	1382306.JNIM01000001_gene244	8.95e-93	316.0	COG0849@1|root,COG0849@2|Bacteria	2|Bacteria	D	cell division	-	-	-	-	-	-	-	-	-	-	-	-	FtsA
TLS1_k127_3960852_2	1380370.JIBA01000015_gene171	9.386e-86	288.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4FIR9@85021|Intrasporangiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS1_k127_3960852_5	1206101.AZXC01000005_gene2747	0.0002702	53.0	COG4990@1|root,COG4990@2|Bacteria,2H2VZ@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4872)	-	-	-	-	-	-	-	-	-	-	-	-	BtrH_N,DUF4872
TLS1_k127_3960852_3	383372.Rcas_3575	9.239e-47	175.0	COG1014@1|root,COG1014@2|Bacteria,2G6FV@200795|Chloroflexi	200795|Chloroflexi	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	porG	-	1.2.7.1,1.2.7.3	ko:K00172,ko:K00177	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00307,M00374,M00620	R01196,R01197,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
TLS1_k127_3960852_1	635013.TherJR_1677	9.026e-87	311.0	COG1013@1|root,COG1013@2|Bacteria,1UZ67@1239|Firmicutes,247Q7@186801|Clostridia,2613R@186807|Peptococcaceae	186801|Clostridia	C	PFAM Thiamine pyrophosphate	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
TLS1_k127_3960852_0	555079.Toce_0834	2.687e-118	394.0	COG0674@1|root,COG0674@2|Bacteria,1TSSC@1239|Firmicutes,248I6@186801|Clostridia,42F8P@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Pyruvate flavodoxin ferredoxin oxidoreductase	vorB	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
TLS1_k127_3960852_4	555079.Toce_0833	1.446e-17	83.0	COG1146@1|root,COG1146@2|Bacteria,1VETY@1239|Firmicutes,25ETJ@186801|Clostridia,42HK8@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S binding domain	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
TLS1_k127_3967771_4	1089551.KE386572_gene1955	3.215e-62	238.0	COG3119@1|root,COG3119@2|Bacteria,1MYHH@1224|Proteobacteria,2UA67@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS1_k127_3967771_3	880072.Desac_1693	9.796e-86	301.0	COG1941@1|root,COG1941@2|Bacteria,1NS0E@1224|Proteobacteria,42U69@68525|delta/epsilon subdivisions,2WQJZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NADH ubiquinone oxidoreductase 20 kDa subunit	hyhS	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
TLS1_k127_3967771_0	391625.PPSIR1_39870	2.004e-154	518.0	COG0479@1|root,COG0543@1|root,COG0479@2|Bacteria,COG0543@2|Bacteria,1QVWG@1224|Proteobacteria,43BWA@68525|delta/epsilon subdivisions,2X771@28221|Deltaproteobacteria,2YUJP@29|Myxococcales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
TLS1_k127_3967771_6	518766.Rmar_2587	2.981e-21	109.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	crp	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	cNMP_binding
TLS1_k127_3967771_2	747365.Thena_0401	4.805e-112	377.0	COG0451@1|root,COG0451@2|Bacteria,1VP6I@1239|Firmicutes,251A8@186801|Clostridia	186801|Clostridia	M	epimerase dehydratase	-	-	4.2.1.46,5.1.3.2	ko:K01710,ko:K01784	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R02984,R06513	RC00289,RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
TLS1_k127_3967771_1	926569.ANT_16210	1.197e-125	415.0	COG0039@1|root,COG0039@2|Bacteria,2G61S@200795|Chloroflexi	200795|Chloroflexi	C	Catalyzes the reversible oxidation of malate to oxaloacetate	ldh	-	1.1.1.27	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	-	R00703,R01000,R03104	RC00031,RC00044	ko00000,ko00001,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
TLS1_k127_3967771_5	1267534.KB906754_gene3729	9.997e-31	140.0	COG0728@1|root,COG0728@2|Bacteria,3Y31G@57723|Acidobacteria,2JI21@204432|Acidobacteriia	204432|Acidobacteriia	S	virulence factor MVIN family protein	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
TLS1_k127_3982346_7	246197.MXAN_5406	4.869e-12	70.0	COG5649@1|root,COG5649@2|Bacteria,1RGY3@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
TLS1_k127_3982346_6	331113.SNE_A18580	1.634e-16	86.0	COG3070@1|root,COG3070@2|Bacteria	2|Bacteria	K	positive regulation of type IV pilus biogenesis	-	-	-	ko:K07343	-	-	-	-	ko00000	-	-	-	TfoX_N
TLS1_k127_3982346_5	1440774.Y900_010090	3.145e-26	113.0	COG3339@1|root,COG3339@2|Bacteria,2IMW8@201174|Actinobacteria,23ARA@1762|Mycobacteriaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
TLS1_k127_3982346_10	562973.HMPREF0059_00949	0.0008163	48.0	COG1961@1|root,COG1961@2|Bacteria,2I8HV@201174|Actinobacteria,4D3ZA@85005|Actinomycetales	201174|Actinobacteria	L	Psort location Cytoplasmic, score 7.50	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS1_k127_3982346_3	1382306.JNIM01000001_gene440	3.922e-49	198.0	COG0477@1|root,COG2814@2|Bacteria,2G97R@200795|Chloroflexi	200795|Chloroflexi	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS1_k127_3982346_8	324602.Caur_3800	6.591e-06	53.0	COG5401@1|root,COG5401@2|Bacteria,2GAF3@200795|Chloroflexi,375WF@32061|Chloroflexia	32061|Chloroflexia	S	PFAM Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane
TLS1_k127_3982346_9	368407.Memar_1212	1.286e-05	55.0	COG3291@1|root,arCOG02527@1|root,arCOG02508@2157|Archaea,arCOG02527@2157|Archaea	2157|Archaea	G	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_2,Big_5,CHB_HEX_C_1,PKD,PMBR,PQQ_3,Peptidase_S9,Polysacc_deac_1
TLS1_k127_3982346_4	926550.CLDAP_22720	5.521e-31	141.0	COG0451@1|root,COG0451@2|Bacteria,2G74B@200795|Chloroflexi	200795|Chloroflexi	GM	Protein of unknown function (DUF4012)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4012
TLS1_k127_3982346_2	926569.ANT_17090	2.25e-80	290.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,2G5WM@200795|Chloroflexi	200795|Chloroflexi	DM	PFAM lipopolysaccharide biosynthesis protein	-	-	2.7.10.2	ko:K08253	-	-	-	-	ko00000,ko01000	-	-	-	CbiA,GNVR,Wzz
TLS1_k127_3982346_1	1303692.SFUL_5906	2.265e-93	321.0	COG0438@1|root,COG0438@2|Bacteria,2GMI6@201174|Actinobacteria	201174|Actinobacteria	M	glycosyl transferase group 1	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glycos_transf_1
TLS1_k127_3982346_0	402777.KB235898_gene5258	6.484e-96	320.0	COG1089@1|root,COG1089@2|Bacteria,1G0M4@1117|Cyanobacteria,1H6XT@1150|Oscillatoriales	1117|Cyanobacteria	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
TLS1_k127_4054076_1	926560.KE387027_gene1021	1.484e-94	324.0	2DB7V@1|root,2Z7NX@2|Bacteria,1WM7S@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4054076_6	479434.Sthe_2193	1.177e-41	162.0	COG0491@1|root,COG0491@2|Bacteria,2G6X9@200795|Chloroflexi,27YDW@189775|Thermomicrobia	189775|Thermomicrobia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS1_k127_4054076_7	1382306.JNIM01000001_gene2450	3.5e-34	149.0	COG3427@1|root,COG3427@2|Bacteria	2|Bacteria	E	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
TLS1_k127_4054076_5	1123228.AUIH01000004_gene1087	1.446e-62	235.0	COG1975@1|root,COG3350@1|root,COG1975@2|Bacteria,COG3350@2|Bacteria,1MWFN@1224|Proteobacteria,1RV4F@1236|Gammaproteobacteria,1XQ7H@135619|Oceanospirillales	135619|Oceanospirillales	O	XdhC Rossmann domain	-	-	-	-	-	-	-	-	-	-	-	-	XdhC_C,XdhC_CoxI
TLS1_k127_4054076_0	518766.Rmar_2766	0.0	1235.0	COG1529@1|root,COG1529@2|Bacteria,4NFF5@976|Bacteroidetes	976|Bacteroidetes	C	Aldehyde oxidase and xanthine dehydrogenase a b hammerhead	-	-	1.17.1.4,1.2.5.3	ko:K03520,ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS1_k127_4054076_3	1382306.JNIM01000001_gene2695	3.268e-67	237.0	COG2080@1|root,COG2080@2|Bacteria,2G6NT@200795|Chloroflexi	200795|Chloroflexi	C	2Fe-2S -binding domain protein	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
TLS1_k127_4054076_4	479434.Sthe_2778	1.571e-64	234.0	COG1319@1|root,COG1319@2|Bacteria,2G84Z@200795|Chloroflexi,27Z3G@189775|Thermomicrobia	189775|Thermomicrobia	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
TLS1_k127_4054076_8	469383.Cwoe_3000	3.753e-21	108.0	COG3324@1|root,COG3324@2|Bacteria,2GPAS@201174|Actinobacteria	201174|Actinobacteria	E	translation initiation factor activity	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS1_k127_4054076_2	1463887.KL589976_gene5910	1.744e-67	238.0	COG0640@1|root,COG3832@1|root,COG0640@2|Bacteria,COG3832@2|Bacteria,2GNW2@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,HTH_20
TLS1_k127_4118864_0	357808.RoseRS_0142	1.784e-195	640.0	COG0210@1|root,COG0210@2|Bacteria,2G5XF@200795|Chloroflexi,3753T@32061|Chloroflexia	32061|Chloroflexia	L	PFAM UvrD REP helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
TLS1_k127_4118864_2	63737.Npun_R5717	5.712e-82	298.0	COG1304@1|root,COG1304@2|Bacteria,1G32Y@1117|Cyanobacteria,1HJ7B@1161|Nostocales	1117|Cyanobacteria	C	PFAM FMN-dependent dehydrogenase	lldD	-	1.1.2.3,1.1.3.46	ko:K00101,ko:K16422	ko00261,ko00620,ko01055,ko01100,ko01130,map00261,map00620,map01055,map01100,map01130	-	R00196,R06633	RC00044,RC00240	ko00000,ko00001,ko01000	-	-	-	FMN_dh
TLS1_k127_4118864_1	358681.BBR47_06860	3.526e-189	614.0	COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,4HA1D@91061|Bacilli,26QDH@186822|Paenibacillaceae	91061|Bacilli	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
TLS1_k127_4118864_3	1449063.JMLS01000013_gene6084	5.75e-37	154.0	COG0454@1|root,COG0454@2|Bacteria,1UHT6@1239|Firmicutes,4IS8U@91061|Bacilli	91061|Bacilli	K	Acetyltransferase (GNAT) domain	yitH	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
TLS1_k127_4118864_4	309801.trd_1757	1.205e-18	97.0	COG0721@1|root,COG0721@2|Bacteria,2G763@200795|Chloroflexi,27YK5@189775|Thermomicrobia	189775|Thermomicrobia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
TLS1_k127_4118864_5	77635.BISU_0299	1.365e-05	53.0	COG0154@1|root,COG0154@2|Bacteria,2GJK5@201174|Actinobacteria,4CZ1X@85004|Bifidobacteriales	201174|Actinobacteria	F	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	GO:0008150,GO:0040007	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TLS1_k127_4194830_16	66874.JOFS01000005_gene4227	1.14e-31	127.0	COG5002@1|root,COG5002@2|Bacteria,2GIX7@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
TLS1_k127_4194830_19	1089545.KB913037_gene2338	7.118e-12	78.0	COG0477@1|root,COG2814@2|Bacteria,2HRV9@201174|Actinobacteria,4E1KT@85010|Pseudonocardiales	201174|Actinobacteria	EGP	Arabinose efflux permease family protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS1_k127_4194830_3	316274.Haur_3105	2.151e-166	541.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	scpD	-	3.4.17.18	ko:K05996	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	P_proprotein,Peptidase_M14
TLS1_k127_4194830_20	1229780.BN381_220038	1.503e-11	70.0	COG4454@1|root,COG4454@2|Bacteria	2|Bacteria	-	-	copC	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1,CusF_Ec
TLS1_k127_4194830_6	1713.JOFV01000022_gene1683	4.123e-106	356.0	COG1062@1|root,COG1062@2|Bacteria,2GM8C@201174|Actinobacteria,4F2K7@85016|Cellulomonadaceae	201174|Actinobacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS1_k127_4194830_7	1242864.D187_004980	6.696e-97	324.0	COG3483@1|root,COG3483@2|Bacteria,1MW68@1224|Proteobacteria,42YUJ@68525|delta/epsilon subdivisions,2WTUY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety	kynA	GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.13.11.11	ko:K00453	ko00380,ko01100,map00380,map01100	M00038	R00678	RC00356	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_dioxygenase
TLS1_k127_4194830_4	234267.Acid_3971	8.058e-146	474.0	COG1252@1|root,COG1252@2|Bacteria,3Y308@57723|Acidobacteria	57723|Acidobacteria	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TLS1_k127_4194830_10	1449347.JQLN01000003_gene6004	1.114e-89	311.0	COG0477@1|root,COG0477@2|Bacteria,2GKFJ@201174|Actinobacteria,2M1BY@2063|Kitasatospora	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	ko:K08225	-	-	-	-	ko00000,ko02000	2.A.1.38	-	-	MFS_3
TLS1_k127_4194830_0	1382306.JNIM01000001_gene426	0.0	1049.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2G5W2@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
TLS1_k127_4194830_18	518766.Rmar_1284	5.338e-29	130.0	COG1018@1|root,COG1018@2|Bacteria,4PEIX@976|Bacteroidetes,1FJ74@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Oxidoreductase NAD-binding domain	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	FAD_binding_6,NAD_binding_1
TLS1_k127_4194830_9	338963.Pcar_0753	9.667e-90	305.0	COG0543@1|root,COG0543@2|Bacteria,1NTWI@1224|Proteobacteria,42M66@68525|delta/epsilon subdivisions,2WJJ2@28221|Deltaproteobacteria,43U7N@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	oxidoreductase FAD NAD(P)-binding domain protein	nfnB	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
TLS1_k127_4194830_1	338963.Pcar_0752	1.42e-189	616.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WJHC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM glutamate synthase (NADPH), homotetrameric	nfnA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2
TLS1_k127_4194830_8	298654.FraEuI1c_1271	1.418e-91	314.0	COG0665@1|root,COG0665@2|Bacteria,2I9WR@201174|Actinobacteria,4EUT8@85013|Frankiales	201174|Actinobacteria	E	FAD dependent oxidoreductase	solA	-	1.5.3.1	ko:K00301	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
TLS1_k127_4194830_2	311424.DhcVS_693	1.33e-168	542.0	COG0423@1|root,COG0423@2|Bacteria,2G62M@200795|Chloroflexi,34D2R@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyS	-	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
TLS1_k127_4194830_5	1320556.AVBP01000012_gene3572	3.191e-107	364.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,2TR5C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Zn-dependent dipeptidase, microsomal dipeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M19
TLS1_k127_4194830_15	1128421.JAGA01000002_gene486	2.39e-46	179.0	COG1381@1|root,COG1381@2|Bacteria,2NPV3@2323|unclassified Bacteria	2|Bacteria	L	Involved in DNA repair and RecF pathway recombination	recO	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
TLS1_k127_4194830_13	208439.AJAP_39235	3.216e-70	256.0	COG2227@1|root,COG2227@2|Bacteria,2I457@201174|Actinobacteria	201174|Actinobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS1_k127_4194830_12	1041930.Mtc_0877	2.831e-73	259.0	COG0142@1|root,arCOG01726@2157|Archaea,2XTAC@28890|Euryarchaeota,2N97R@224756|Methanomicrobia	224756|Methanomicrobia	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
TLS1_k127_4194830_17	502025.Hoch_2580	8.186e-30	132.0	COG2764@1|root,COG2764@2|Bacteria,1RF5T@1224|Proteobacteria,434KP@68525|delta/epsilon subdivisions,2WYXY@28221|Deltaproteobacteria,2Z0W7@29|Myxococcales	28221|Deltaproteobacteria	C	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS1_k127_4194830_11	1382306.JNIM01000001_gene3771	6.954e-88	308.0	COG1253@1|root,COG1253@2|Bacteria,2G67V@200795|Chloroflexi	200795|Chloroflexi	S	CBS domain containing protein	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
TLS1_k127_4217889_5	710686.Mycsm_02059	2.491e-13	70.0	COG0575@1|root,COG0575@2|Bacteria,2I9PE@201174|Actinobacteria,234SC@1762|Mycobacteriaceae	201174|Actinobacteria	I	Cytidylyltransferase family	cdsA_1	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
TLS1_k127_4217889_1	765420.OSCT_1933	9.815e-50	194.0	COG0745@1|root,COG4963@1|root,COG0745@2|Bacteria,COG4963@2|Bacteria,2G89B@200795|Chloroflexi,377XT@32061|Chloroflexia	200795|Chloroflexi	D	Cellulose biosynthesis protein BcsQ	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	CBP_BcsQ,Response_reg
TLS1_k127_4217889_4	1121423.JONT01000003_gene1119	4.274e-17	96.0	COG0360@1|root,COG0360@2|Bacteria,1VA18@1239|Firmicutes,24QZQ@186801|Clostridia,262C6@186807|Peptococcaceae	186801|Clostridia	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
TLS1_k127_4217889_2	1288826.MSNKSG1_17910	4.891e-27	118.0	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,1S3WP@1236|Gammaproteobacteria,466WC@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363,GO:1901576	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
TLS1_k127_4217889_3	525904.Tter_0780	5.824e-25	106.0	COG0238@1|root,COG0238@2|Bacteria,2NQ53@2323|unclassified Bacteria	2|Bacteria	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02963,ko:K03111,ko:K15125	ko03010,ko03030,ko03430,ko03440,ko05133,map03010,map03030,map03430,map03440,map05133	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko00536,ko03011,ko03029,ko03032,ko03400	-	-	-	Ribosomal_S18
TLS1_k127_4217889_0	635013.TherJR_0845	4.991e-50	189.0	COG0730@1|root,COG0730@2|Bacteria,1TRFG@1239|Firmicutes,258JQ@186801|Clostridia,2605C@186807|Peptococcaceae	186801|Clostridia	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS1_k127_4236381_2	1041159.AZUW01000063_gene411	9.377e-85	303.0	COG2333@1|root,COG2333@2|Bacteria,1RE10@1224|Proteobacteria,2U7SC@28211|Alphaproteobacteria,4BI87@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	competence protein COMEC	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS1_k127_4236381_0	1041159.AZUW01000062_gene3637	3.528e-196	633.0	COG1404@1|root,COG1404@2|Bacteria,1PSEZ@1224|Proteobacteria,2V4M5@28211|Alphaproteobacteria,4BFDK@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
TLS1_k127_4236381_8	1347392.CCEZ01000043_gene545	0.0004888	47.0	2DR6A@1|root,33ACN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4236381_5	552811.Dehly_0111	2.137e-27	121.0	COG0344@1|root,COG0344@2|Bacteria,2G6U5@200795|Chloroflexi,34D23@301297|Dehalococcoidia	301297|Dehalococcoidia	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	-	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
TLS1_k127_4236381_3	479434.Sthe_3107	1.003e-46	193.0	COG1893@1|root,COG1893@2|Bacteria,2G718@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
TLS1_k127_4236381_1	324602.Caur_3289	6.241e-127	424.0	COG0247@1|root,COG0247@2|Bacteria,2G7VD@200795|Chloroflexi,3754W@32061|Chloroflexia	32061|Chloroflexia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.1.5.3	ko:K00113	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_8
TLS1_k127_4236381_7	882.DVU_1939	8.223e-11	66.0	COG3075@1|root,COG3075@2|Bacteria,1MU3K@1224|Proteobacteria,42Q09@68525|delta/epsilon subdivisions,2WKE0@28221|Deltaproteobacteria,2M7WY@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Glycerol-3-phosphate dehydrogenase, anaerobic, B subunit	glpB	-	1.1.5.3	ko:K00112	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2
TLS1_k127_4264423_8	994573.T472_0203205	0.0001175	47.0	2EBE7@1|root,335EV@2|Bacteria,1VHAQ@1239|Firmicutes,253H4@186801|Clostridia	186801|Clostridia	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS1_k127_4264423_1	469383.Cwoe_1126	7.979e-119	416.0	COG2909@1|root,COG3899@1|root,COG2909@2|Bacteria,COG3899@2|Bacteria,2GJIA@201174|Actinobacteria,4CRFK@84995|Rubrobacteria	84995|Rubrobacteria	K	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS1_k127_4264423_5	1134445.AJJM01000199_gene3816	1.948e-64	228.0	COG1309@1|root,COG1309@2|Bacteria,2GV75@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
TLS1_k127_4264423_6	1151122.AQYD01000007_gene664	3.226e-54	194.0	COG0748@1|root,COG0748@2|Bacteria,2IP6Y@201174|Actinobacteria,4FS9X@85023|Microbacteriaceae	201174|Actinobacteria	P	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
TLS1_k127_4264423_7	1114959.SZMC14600_03241	7.706e-13	76.0	COG3832@1|root,COG3832@2|Bacteria,2HJ9Q@201174|Actinobacteria,4E3GA@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM Polyketide cyclase dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS1_k127_4264423_4	1123023.JIAI01000001_gene6765	4.8e-109	361.0	COG1595@1|root,COG1595@2|Bacteria,2GKBH@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2,SnoaL_2
TLS1_k127_4264423_0	1120959.ATXF01000005_gene1312	3.508e-142	464.0	COG2270@1|root,COG2270@2|Bacteria,2GJSA@201174|Actinobacteria,4FM1H@85023|Microbacteriaceae	201174|Actinobacteria	S	Major Facilitator Superfamily	cmr	-	-	ko:K18833	-	-	-	-	ko00000,ko01504,ko02000	2.A.1.21.2	-	-	MFS_1
TLS1_k127_4264423_2	1123023.JIAI01000001_gene6764	4.327e-118	389.0	COG0451@1|root,COG0451@2|Bacteria,2I2SW@201174|Actinobacteria,4E47R@85010|Pseudonocardiales	201174|Actinobacteria	GM	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10
TLS1_k127_4264423_3	1265310.CCBD010000050_gene1996	5.801e-118	417.0	COG2114@1|root,COG2197@1|root,COG3903@1|root,COG2114@2|Bacteria,COG2197@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,233DM@1762|Mycobacteriaceae	201174|Actinobacteria	K	involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Guanylate_cyc,NB-ARC
TLS1_k127_4266100_4	1382306.JNIM01000001_gene535	8.059e-51	190.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25
TLS1_k127_4266100_1	1385518.N798_15305	5.282e-91	305.0	COG0500@1|root,COG2226@2|Bacteria,2GNTH@201174|Actinobacteria,4FE9T@85021|Intrasporangiaceae	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS1_k127_4266100_8	765420.OSCT_0897	6.771e-14	81.0	COG0789@1|root,COG0789@2|Bacteria,2GBIN@200795|Chloroflexi,375XH@32061|Chloroflexia	32061|Chloroflexia	L	TIGRFAM DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
TLS1_k127_4266100_9	1157490.EL26_10410	1.851e-07	64.0	COG2217@1|root,COG2217@2|Bacteria,1VJJE@1239|Firmicutes,4HM5J@91061|Bacilli,278HV@186823|Alicyclobacillaceae	91061|Bacilli	P	Heavy metal translocating P-type atpase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4266100_6	926569.ANT_02430	1.169e-22	112.0	2A1JS@1|root,30PTP@2|Bacteria,2G9H1@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4266100_3	1128421.JAGA01000003_gene3259	1.914e-63	224.0	COG2197@1|root,COG2197@2|Bacteria,2NR2Y@2323|unclassified Bacteria	2|Bacteria	T	helix_turn_helix, Lux Regulon	yhcZ	-	-	ko:K02479	-	-	-	-	ko00000,ko02022	-	-	-	GerE,Response_reg
TLS1_k127_4266100_5	1293048.CBMB010000004_gene2387	1.022e-44	175.0	COG0596@1|root,arCOG01648@2157|Archaea,2XVXV@28890|Euryarchaeota,23TR9@183963|Halobacteria	183963|Halobacteria	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS1_k127_4266100_0	1267535.KB906767_gene4080	6.475e-110	364.0	COG1210@1|root,COG1210@2|Bacteria,3Y39W@57723|Acidobacteria,2JHXA@204432|Acidobacteriia	204432|Acidobacteriia	M	UTP-glucose-1-phosphate uridylyltransferase	-	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TLS1_k127_4266100_7	512565.AMIS_59390	1.78e-15	83.0	arCOG05230@1|root,33GXI@2|Bacteria,2ICB0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4266100_2	1121468.AUBR01000005_gene40	5.642e-78	278.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,42EW8@68295|Thermoanaerobacterales	186801|Clostridia	KLT	Serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
TLS1_k127_4268931_4	266117.Rxyl_0995	5.122e-68	237.0	COG0047@1|root,COG0047@2|Bacteria,2GMJY@201174|Actinobacteria,4CPW1@84995|Rubrobacteria	84995|Rubrobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
TLS1_k127_4268931_5	1123229.AUBC01000003_gene2072	9.681e-13	80.0	COG1828@1|root,COG1828@2|Bacteria,1N83G@1224|Proteobacteria,2UF7S@28211|Alphaproteobacteria,3K02S@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
TLS1_k127_4268931_3	1380390.JIAT01000009_gene1486	7.568e-103	349.0	COG0152@1|root,COG0152@2|Bacteria,2GK3H@201174|Actinobacteria,4CPBJ@84995|Rubrobacteria	84995|Rubrobacteria	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
TLS1_k127_4268931_1	477974.Daud_1634	4.482e-130	449.0	COG0015@1|root,COG0015@2|Bacteria,1TPMM@1239|Firmicutes,2485N@186801|Clostridia,260RX@186807|Peptococcaceae	186801|Clostridia	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
TLS1_k127_4268931_2	290397.Adeh_2467	1.96e-107	374.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,42MCI@68525|delta/epsilon subdivisions,2WJ7H@28221|Deltaproteobacteria,2YU6X@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC,GARS_A,GARS_C,GARS_N
TLS1_k127_4268931_0	1051632.TPY_3808	2.692e-149	485.0	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,247RN@186801|Clostridia,3WCYT@538999|Clostridiales incertae sedis	186801|Clostridia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
TLS1_k127_4279807_6	694431.DESACE_08920	3.963e-42	156.0	COG2189@1|root,COG2189@2|Bacteria	2|Bacteria	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.72	ko:K00571,ko:K07319	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
TLS1_k127_4279807_10	867845.KI911784_gene427	1.551e-26	110.0	COG0254@1|root,COG0254@2|Bacteria,2G75A@200795|Chloroflexi,375Y4@32061|Chloroflexia	32061|Chloroflexia	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
TLS1_k127_4279807_11	309801.trd_1425	2.614e-22	100.0	COG0211@1|root,COG0211@2|Bacteria,2G7BE@200795|Chloroflexi,27YJD@189775|Thermomicrobia	189775|Thermomicrobia	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
TLS1_k127_4279807_9	479434.Sthe_1805	3.35e-28	122.0	COG0261@1|root,COG0261@2|Bacteria,2G72T@200795|Chloroflexi,27YJB@189775|Thermomicrobia	189775|Thermomicrobia	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
TLS1_k127_4279807_8	675635.Psed_0983	4.053e-29	119.0	COG0640@1|root,COG0640@2|Bacteria,2IR66@201174|Actinobacteria	201174|Actinobacteria	K	arsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
TLS1_k127_4279807_7	29306.JOBE01000030_gene940	3.229e-32	132.0	COG3832@1|root,COG3832@2|Bacteria,2GSCI@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS1_k127_4279807_13	926569.ANT_22530	2.899e-07	64.0	COG5011@1|root,COG5011@2|Bacteria,2G71I@200795|Chloroflexi	200795|Chloroflexi	S	Uncharacterized protein conserved in bacteria (DUF2344)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344
TLS1_k127_4279807_5	1521187.JPIM01000029_gene1569	1.486e-48	190.0	COG0628@1|root,COG0628@2|Bacteria,2G712@200795|Chloroflexi,375FE@32061|Chloroflexia	32061|Chloroflexia	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS1_k127_4279807_12	317655.Sala_2059	2.692e-12	75.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2TRZ1@28211|Alphaproteobacteria,2K1EY@204457|Sphingomonadales	204457|Sphingomonadales	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
TLS1_k127_4279807_3	1321781.HMPREF1985_02184	5.945e-78	274.0	COG0772@1|root,COG0772@2|Bacteria,1TPGH@1239|Firmicutes,4H21I@909932|Negativicutes	909932|Negativicutes	M	Peptidoglycan polymerase that is essential for cell wall elongation	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
TLS1_k127_4279807_1	1122217.KB899578_gene1796	6.605e-104	361.0	COG0768@1|root,COG0768@2|Bacteria,1TQHY@1239|Firmicutes,4H3C8@909932|Negativicutes	909932|Negativicutes	M	Penicillin-binding protein 2	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
TLS1_k127_4279807_14	926550.CLDAP_08150	5.887e-05	53.0	COG2891@1|root,COG2891@2|Bacteria	2|Bacteria	M	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins	mreD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
TLS1_k127_4279807_2	697281.Mahau_2951	4.195e-87	295.0	COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,2488C@186801|Clostridia,42F5R@68295|Thermoanaerobacterales	186801|Clostridia	D	PFAM Cobyrinic acid a,c-diamide synthase	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
TLS1_k127_4279807_4	479434.Sthe_0467	9.515e-71	254.0	COG1475@1|root,COG1475@2|Bacteria,2G6EK@200795|Chloroflexi,27XFW@189775|Thermomicrobia	189775|Thermomicrobia	K	ParB-like nuclease domain	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
TLS1_k127_4279807_0	255470.cbdbA4	3.809e-191	608.0	COG0187@1|root,COG0187@2|Bacteria,2G67C@200795|Chloroflexi,34D61@301297|Dehalococcoidia	301297|Dehalococcoidia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
TLS1_k127_4304135_1	525904.Tter_1351	3.223e-104	351.0	COG0075@1|root,COG0075@2|Bacteria,2NP52@2323|unclassified Bacteria	2|Bacteria	E	Aminotransferase class-V	dhsS	-	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	iJN678.sll1559,iSB619.SA_RS08700	Aminotran_5
TLS1_k127_4304135_0	1128421.JAGA01000001_gene2412	4.242e-153	505.0	COG1052@1|root,COG1052@2|Bacteria,2NS44@2323|unclassified Bacteria	2|Bacteria	E	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	serA	-	1.1.1.310,1.1.1.399,1.1.1.95	ko:K00058,ko:K16843	ko00260,ko00270,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513,R05693	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
TLS1_k127_4304135_5	221360.RS9917_09821	5.296e-20	106.0	COG0406@1|root,COG0406@2|Bacteria,1G1TS@1117|Cyanobacteria,1GZ3A@1129|Synechococcus	1117|Cyanobacteria	G	Belongs to the phosphoglycerate mutase family	gpmB	-	3.1.3.3	ko:K22305	ko00260,ko00680,ko01100,ko01120,ko01130,map00260,map00680,map01100,map01120,map01130	-	R00582	RC00017	ko00000,ko00001,ko01000	-	-	-	His_Phos_1
TLS1_k127_4304135_4	479434.Sthe_1588	2.362e-38	166.0	COG1305@1|root,COG1305@2|Bacteria,2G66M@200795|Chloroflexi,27XNH@189775|Thermomicrobia	189775|Thermomicrobia	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129,Transglut_core
TLS1_k127_4304135_3	357808.RoseRS_3160	5.387e-61	226.0	COG1721@1|root,COG1721@2|Bacteria,2G5XH@200795|Chloroflexi,374YS@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
TLS1_k127_4304135_2	1128421.JAGA01000002_gene222	2.522e-93	312.0	COG0714@1|root,COG0714@2|Bacteria,2NNMQ@2323|unclassified Bacteria	2|Bacteria	S	ATPase associated with various cellular	moxR1	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TLS1_k127_4305356_3	1382356.JQMP01000003_gene2395	7.219e-72	276.0	COG5621@1|root,COG5621@2|Bacteria,2G6EI@200795|Chloroflexi,27YRR@189775|Thermomicrobia	189775|Thermomicrobia	S	Lipocalin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9
TLS1_k127_4305356_1	485913.Krac_7571	3.139e-188	629.0	COG2409@1|root,COG2409@2|Bacteria,2G6XZ@200795|Chloroflexi	200795|Chloroflexi	S	PFAM MMPL domain protein	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
TLS1_k127_4305356_5	68194.JNXR01000018_gene486	9.667e-26	115.0	2EK1S@1|root,33DS8@2|Bacteria,2H41Z@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4305356_4	479434.Sthe_2722	1.964e-29	126.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS1_k127_4305356_0	926569.ANT_25010	1.344e-217	690.0	COG1509@1|root,COG1509@2|Bacteria,2G7ZT@200795|Chloroflexi	200795|Chloroflexi	H	Lysine-2,3-aminomutase	-	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,LAM_C,Radical_SAM
TLS1_k127_4305356_2	1380390.JIAT01000009_gene1628	5.47e-106	378.0	COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS1_k127_4329598_1	1123313.ATUT01000026_gene2	8.593e-44	171.0	COG0265@1|root,COG0265@2|Bacteria,1TRM8@1239|Firmicutes,3VNVB@526524|Erysipelotrichia	526524|Erysipelotrichia	O	typically periplasmic, contain C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
TLS1_k127_4329598_3	1001240.GY21_18650	1.002e-07	63.0	28X0E@1|root,2ZIZA@2|Bacteria,2HC0F@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4329598_0	536019.Mesop_4322	7.342e-205	660.0	COG3408@1|root,COG3408@2|Bacteria,1MUYU@1224|Proteobacteria,2TQK2@28211|Alphaproteobacteria,43IC9@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	PFAM Amylo-alpha-16-glucosidase	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N_bis
TLS1_k127_4329598_2	1430331.EP10_03210	1.869e-35	139.0	COG0395@1|root,COG0395@2|Bacteria,1TRCP@1239|Firmicutes,4HBYE@91061|Bacilli,1WG2D@129337|Geobacillus	91061|Bacilli	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS1_k127_435522_16	1210908.HSB1_18210	1.076e-21	105.0	COG2259@1|root,arCOG02861@2157|Archaea,2XWGS@28890|Euryarchaeota,23VFU@183963|Halobacteria	183963|Halobacteria	S	DoxX	doxD1	-	1.8.5.2	ko:K16937	ko00920,ko01120,map00920,map01120	-	R07177	-	ko00000,ko00001,ko01000	3.D.4.9	-	-	DoxX
TLS1_k127_435522_4	1382306.JNIM01000001_gene1777	5.327e-95	334.0	COG0123@1|root,COG0454@1|root,COG0123@2|Bacteria,COG0454@2|Bacteria,2G5X3@200795|Chloroflexi	200795|Chloroflexi	BQ	PFAM histone deacetylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
TLS1_k127_435522_19	742742.HMPREF9452_01341	0.0005687	47.0	COG1826@1|root,COG1826@2|Bacteria,2HVCG@201174|Actinobacteria,4CWNJ@84998|Coriobacteriia	84998|Coriobacteriia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106,zinc_ribbon_2
TLS1_k127_435522_3	1007103.AFHW01000147_gene1354	9.041e-103	355.0	COG1080@1|root,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,4H9VD@91061|Bacilli,26QD5@186822|Paenibacillaceae	91061|Bacilli	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	-	-	-	-	-	-	-	-	-	-	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
TLS1_k127_435522_6	479431.Namu_1660	9.006e-51	190.0	COG1461@1|root,COG1461@2|Bacteria,2HEQ9@201174|Actinobacteria,4EVEA@85013|Frankiales	201174|Actinobacteria	S	TIGRFAM dihydroxyacetone kinase, L subunit	dhaL	-	2.7.1.121	ko:K05879	ko00561,ko01100,map00561,map01100	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000	-	-	-	Dak2
TLS1_k127_435522_2	1380393.JHVP01000010_gene2977	2.654e-144	473.0	COG2376@1|root,COG2376@2|Bacteria,2GJV9@201174|Actinobacteria,4EU6G@85013|Frankiales	201174|Actinobacteria	G	PFAM Dak kinase	dhaK	-	2.7.1.121,2.7.1.28,2.7.1.29,4.6.1.15	ko:K00863,ko:K05878	ko00051,ko00561,ko00680,ko01100,ko01120,ko01200,ko04622,map00051,map00561,map00680,map01100,map01120,map01200,map04622	M00344	R01011,R01012,R01059	RC00002,RC00015,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Dak1
TLS1_k127_435522_18	584708.Apau_1949	3.285e-15	78.0	COG1925@1|root,COG1925@2|Bacteria,3TBIP@508458|Synergistetes	508458|Synergistetes	H	TIGRFAM Phosphotransferase System HPr (HPr) Family	-	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
TLS1_k127_435522_14	479434.Sthe_3120	2.271e-24	109.0	COG3412@1|root,COG3412@2|Bacteria,2GAUU@200795|Chloroflexi,27Z9J@189775|Thermomicrobia	189775|Thermomicrobia	S	PTS system fructose IIA component	-	-	2.7.1.121	ko:K05881	ko00561,map00561	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000,ko02000	-	-	-	EIIA-man
TLS1_k127_435522_17	1122622.ATWJ01000007_gene2033	1.841e-16	87.0	2B8WS@1|root,32271@2|Bacteria,2H6HE@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	3.2.2.28	ko:K03649	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
TLS1_k127_435522_8	987059.RBXJA2T_01535	5.637e-43	173.0	COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,2VICE@28216|Betaproteobacteria,1KN7G@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,NUDIX
TLS1_k127_435522_5	1219084.AP014508_gene1160	7.134e-64	250.0	COG1404@1|root,COG1404@2|Bacteria,2GDZM@200918|Thermotogae	200918|Thermotogae	O	Subtilase family	-	-	3.4.21.62	ko:K01342	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Peptidase_S8
TLS1_k127_435522_13	1500259.JQLD01000002_gene3008	5.383e-25	123.0	COG2202@1|root,COG2982@1|root,COG3209@1|root,COG3210@1|root,COG5295@1|root,COG2202@2|Bacteria,COG2982@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,COG5295@2|Bacteria,1QUXB@1224|Proteobacteria,2TWTY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,DUF4347
TLS1_k127_435522_9	405948.SACE_6176	1.031e-35	142.0	COG0454@1|root,COG0456@2|Bacteria,2IQC7@201174|Actinobacteria,4E3GV@85010|Pseudonocardiales	201174|Actinobacteria	K	PFAM Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS1_k127_435522_0	1128421.JAGA01000002_gene1742	6.048e-209	681.0	COG1331@1|root,COG1331@2|Bacteria,2NP26@2323|unclassified Bacteria	2|Bacteria	O	Protein of unknown function, DUF255	yyaL	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
TLS1_k127_435522_10	479434.Sthe_1273	1.763e-31	141.0	COG0277@1|root,COG0277@2|Bacteria	2|Bacteria	C	FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
TLS1_k127_435522_7	266117.Rxyl_0369	1.899e-49	188.0	COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,4CTCQ@84995|Rubrobacteria	84995|Rubrobacteria	C	PFAM luciferase-like	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS1_k127_435522_1	684949.ATTJ01000001_gene2186	5.025e-166	531.0	COG1883@1|root,COG1883@2|Bacteria	2|Bacteria	C	oxaloacetate decarboxylase activity	oadB	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
TLS1_k127_435522_12	326427.Cagg_0381	3.984e-25	115.0	COG0511@1|root,COG0511@2|Bacteria,2G971@200795|Chloroflexi,377RI@32061|Chloroflexia	32061|Chloroflexia	I	Biotin-requiring enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
TLS1_k127_435522_15	326427.Cagg_0380	3.446e-23	104.0	COG3630@1|root,COG3630@2|Bacteria	2|Bacteria	C	sodium ion export across plasma membrane	oadG	GO:0003674,GO:0003824,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008948,GO:0015672,GO:0016829,GO:0016830,GO:0016831,GO:0030001,GO:0051179,GO:0051234	4.1.1.3	ko:K01573	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_gamma
TLS1_k127_435522_11	1203605.HMPREF1531_02146	2.819e-25	105.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4DNBQ@85009|Propionibacteriales	201174|Actinobacteria	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
TLS1_k127_4370028_16	756067.MicvaDRAFT_1602	0.0006418	51.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria,1H8AZ@1150|Oscillatoriales	1117|Cyanobacteria	L	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_8
TLS1_k127_4370028_6	1329516.JPST01000038_gene2769	2.465e-55	206.0	COG1624@1|root,COG1624@2|Bacteria,1TPRW@1239|Firmicutes,4H9XZ@91061|Bacilli,27B5R@186824|Thermoactinomycetaceae	91061|Bacilli	S	DisA bacterial checkpoint controller nucleotide-binding	dacA	GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009975,GO:0016020,GO:0016021,GO:0016829,GO:0016849,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
TLS1_k127_4370028_11	644966.Tmar_0237	1.103e-25	121.0	COG4856@1|root,COG4856@2|Bacteria,1TSIV@1239|Firmicutes,24GKC@186801|Clostridia,3WCNK@538999|Clostridiales incertae sedis	186801|Clostridia	S	YbbR-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
TLS1_k127_4370028_1	264732.Moth_2246	1.097e-109	370.0	COG1109@1|root,COG1109@2|Bacteria,1TP1X@1239|Firmicutes,2499P@186801|Clostridia,42EV8@68295|Thermoanaerobacterales	186801|Clostridia	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS1_k127_4370028_0	1121472.AQWN01000001_gene281	1.646e-187	603.0	COG0449@1|root,COG0449@2|Bacteria,1TPGU@1239|Firmicutes,248F8@186801|Clostridia,2608Z@186807|Peptococcaceae	186801|Clostridia	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
TLS1_k127_4370028_10	1382356.JQMP01000003_gene2543	4.561e-27	118.0	COG0736@1|root,COG0736@2|Bacteria,2G73N@200795|Chloroflexi,27YDS@189775|Thermomicrobia	189775|Thermomicrobia	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
TLS1_k127_4370028_4	552811.Dehly_0249	2.823e-59	221.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2G5Y8@200795|Chloroflexi,34D4S@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
TLS1_k127_4370028_3	760568.Desku_1293	6.778e-69	258.0	COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,260IY@186807|Peptococcaceae	186801|Clostridia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
TLS1_k127_4370028_8	370438.PTH_2212	2.586e-31	141.0	COG2110@1|root,COG2755@1|root,COG2110@2|Bacteria,COG2755@2|Bacteria,1VDE2@1239|Firmicutes,24N6X@186801|Clostridia,262J2@186807|Peptococcaceae	186801|Clostridia	E	PFAM GDSL-like Lipase Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
TLS1_k127_4370028_14	867845.KI911784_gene187	8.908e-09	68.0	COG1070@1|root,COG1070@2|Bacteria,2G6JV@200795|Chloroflexi,375CS@32061|Chloroflexia	32061|Chloroflexia	G	MutL protein	-	-	-	-	-	-	-	-	-	-	-	-	MutL
TLS1_k127_4370028_15	1379698.RBG1_1C00001G0120	0.0002558	54.0	28II6@1|root,2Z8JB@2|Bacteria,2NNT1@2323|unclassified Bacteria	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4370028_9	1121430.JMLG01000025_gene92	3.704e-27	124.0	COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,24MSS@186801|Clostridia,2621R@186807|Peptococcaceae	186801|Clostridia	S	PFAM Uncharacterised P-loop hydrolase UPF0079	ydiB	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
TLS1_k127_4370028_12	1449346.JQMO01000003_gene5171	2.44e-17	94.0	COG1214@1|root,COG1214@2|Bacteria,2GMTM@201174|Actinobacteria,2M28B@2063|Kitasatospora	201174|Actinobacteria	O	Glycoprotease family	yeaZ	GO:0002949,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0071944,GO:0090304,GO:1901360	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
TLS1_k127_4370028_7	357808.RoseRS_0876	6.399e-38	161.0	COG0454@1|root,COG0456@2|Bacteria,2G6TF@200795|Chloroflexi,375M6@32061|Chloroflexia	32061|Chloroflexia	K	TIGRFAM ribosomal-protein-alanine acetyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
TLS1_k127_4370028_2	479434.Sthe_0915	2.839e-106	355.0	COG0533@1|root,COG0533@2|Bacteria,2G5V0@200795|Chloroflexi,27XRB@189775|Thermomicrobia	189775|Thermomicrobia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
TLS1_k127_4370028_5	1382356.JQMP01000003_gene1346	1.856e-56	213.0	COG0030@1|root,COG0030@2|Bacteria,2G6DA@200795|Chloroflexi,27XUP@189775|Thermomicrobia	189775|Thermomicrobia	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
TLS1_k127_4370028_13	1125973.JNLC01000011_gene329	1.346e-15	87.0	COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,2TUFV@28211|Alphaproteobacteria,3JQW5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
TLS1_k127_438316_2	292459.STH1622	3.45e-44	180.0	COG0457@1|root,COG3359@1|root,COG0457@2|Bacteria,COG3359@2|Bacteria,1TQQU@1239|Firmicutes	1239|Firmicutes	L	Exonuclease	yprB	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
TLS1_k127_438316_0	644966.Tmar_1056	3.237e-256	812.0	COG1061@1|root,COG1205@1|root,COG1061@2|Bacteria,COG1205@2|Bacteria,1TSPA@1239|Firmicutes,25EG8@186801|Clostridia,3WDQS@538999|Clostridiales incertae sedis	186801|Clostridia	KL	PFAM Helicase conserved C-terminal domain	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
TLS1_k127_438316_3	73044.JNXP01000013_gene1310	1.686e-09	68.0	2EBIV@1|root,335JA@2|Bacteria,2IHZS@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
TLS1_k127_438316_1	1121272.KB903261_gene6155	1.137e-70	259.0	COG2268@1|root,COG2268@2|Bacteria,2GK9I@201174|Actinobacteria,4D8CU@85008|Micromonosporales	201174|Actinobacteria	S	Flotillin	-	-	-	ko:K07192	ko04910,map04910	-	-	-	ko00000,ko00001,ko03036,ko04131,ko04147	-	-	-	Band_7,Flot
TLS1_k127_4389093_0	1122622.ATWJ01000002_gene800	6.604e-127	429.0	COG2114@1|root,COG2197@1|root,COG2114@2|Bacteria,COG2197@2|Bacteria,2GKXJ@201174|Actinobacteria	201174|Actinobacteria	K	PFAM regulatory protein LuxR	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS1_k127_4389093_1	1117943.SFHH103_01292	8.07e-107	348.0	COG0412@1|root,COG0412@2|Bacteria,1MYJ9@1224|Proteobacteria,2UBAU@28211|Alphaproteobacteria,4BA2W@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DLH
TLS1_k127_4389093_5	1380354.JIAN01000006_gene425	3.934e-58	206.0	COG3157@1|root,COG3157@2|Bacteria,2IP19@201174|Actinobacteria	201174|Actinobacteria	S	Type VI secretion system effector, Hcp	-	-	-	ko:K11903	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	T6SS_HCP
TLS1_k127_4389093_7	1385519.N801_05270	3.257e-40	156.0	COG4635@1|root,COG4635@2|Bacteria,2IQCQ@201174|Actinobacteria	201174|Actinobacteria	CH	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
TLS1_k127_4389093_4	37919.EP51_30005	5.491e-60	213.0	COG3865@1|root,COG3865@2|Bacteria,2IIAX@201174|Actinobacteria,4G18G@85025|Nocardiaceae	201174|Actinobacteria	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
TLS1_k127_4389093_8	287986.DV20_34470	1.824e-39	155.0	COG2227@1|root,COG2227@2|Bacteria,2GTJX@201174|Actinobacteria,4EB7A@85010|Pseudonocardiales	201174|Actinobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25
TLS1_k127_4389093_3	1123229.AUBC01000001_gene1573	9.825e-70	248.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,2TRSZ@28211|Alphaproteobacteria,3JR3Z@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	DNA ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
TLS1_k127_4389093_2	1123319.AUBE01000008_gene3933	2.904e-83	282.0	COG0262@1|root,COG0262@2|Bacteria,2GYU7@201174|Actinobacteria	201174|Actinobacteria	H	bifunctional deaminase-reductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS1_k127_4389093_6	35754.JNYJ01000047_gene3547	5.028e-49	180.0	COG5579@1|root,COG5579@2|Bacteria,2IM9J@201174|Actinobacteria,4DECI@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF1810)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1810
TLS1_k127_4389093_9	296591.Bpro_0414	4.222e-35	138.0	COG0160@1|root,COG0160@2|Bacteria,1MX0Y@1224|Proteobacteria,2VMYT@28216|Betaproteobacteria,4AHBM@80864|Comamonadaceae	28216|Betaproteobacteria	H	Aminotransferase class-III	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
TLS1_k127_4391528_5	696281.Desru_1730	8.418e-45	169.0	COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,248V8@186801|Clostridia,260BR@186807|Peptococcaceae	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
TLS1_k127_4391528_2	867845.KI911784_gene3538	2.322e-81	282.0	COG1028@1|root,COG1028@2|Bacteria,2G5KB@200795|Chloroflexi,3759E@32061|Chloroflexia	32061|Chloroflexia	IQ	short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS1_k127_4391528_4	477641.MODMU_2299	5.923e-48	191.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	ubiG	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
TLS1_k127_4391528_10	469383.Cwoe_1863	9.047e-18	95.0	COG0438@1|root,COG0438@2|Bacteria,2I8DC@201174|Actinobacteria,4CR51@84995|Rubrobacteria	84995|Rubrobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
TLS1_k127_4391528_1	404589.Anae109_1244	6.689e-120	398.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42MTX@68525|delta/epsilon subdivisions,2WITE@28221|Deltaproteobacteria,2YZZM@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
TLS1_k127_4391528_0	1123386.AUIW01000007_gene1593	3.55e-133	447.0	COG1086@1|root,COG1086@2|Bacteria,1WIQA@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	PFAM polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
TLS1_k127_4391528_8	562970.Btus_3026	1.48e-32	143.0	COG1316@1|root,COG1316@2|Bacteria,1TR1B@1239|Firmicutes,4HA09@91061|Bacilli,277XC@186823|Alicyclobacillaceae	91061|Bacilli	K	Cell envelope-related transcriptional attenuator domain	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr,SH3_3
TLS1_k127_4391528_6	1120972.AUMH01000023_gene550	1.236e-35	144.0	COG2148@1|root,COG2148@2|Bacteria,1TP7M@1239|Firmicutes,4HB15@91061|Bacilli,27AQE@186823|Alicyclobacillaceae	91061|Bacilli	M	Bacterial sugar transferase	tuaA	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
TLS1_k127_4391528_13	1382303.JPOM01000001_gene1682	8.799e-05	55.0	COG2244@1|root,COG2244@2|Bacteria,1R5ZA@1224|Proteobacteria,2TRJ5@28211|Alphaproteobacteria,2KEY6@204458|Caulobacterales	204458|Caulobacterales	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_3,Polysacc_synt_C
TLS1_k127_4391528_11	871968.DESME_14480	2.325e-17	96.0	COG3307@1|root,COG3307@2|Bacteria,1UYDA@1239|Firmicutes,258NQ@186801|Clostridia,2613J@186807|Peptococcaceae	186801|Clostridia	M	PFAM O-Antigen ligase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
TLS1_k127_4391528_12	557598.LHK_00020	1.365e-06	59.0	COG0454@1|root,COG0456@2|Bacteria,1RH71@1224|Proteobacteria,2VS9R@28216|Betaproteobacteria,2KT76@206351|Neisseriales	206351|Neisseriales	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS1_k127_4391528_3	864069.MicloDRAFT_00025890	1.157e-72	258.0	COG1215@1|root,COG1215@2|Bacteria,1NDPE@1224|Proteobacteria,2TSCT@28211|Alphaproteobacteria,1JUA4@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	PFAM Glycosyl transferase family 2	exoA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K16557	-	-	-	-	ko00000,ko01000,ko01003	-	GT2	-	Glycos_transf_2
TLS1_k127_4391528_9	357808.RoseRS_0249	1.492e-28	129.0	COG1316@1|root,COG1316@2|Bacteria,2G6PZ@200795|Chloroflexi,376MC@32061|Chloroflexia	32061|Chloroflexia	K	TIGRFAM cell envelope-related function transcriptional attenuator, LytR CpsA family	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
TLS1_k127_4391528_7	1382306.JNIM01000001_gene3601	6.662e-33	130.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,2G5VX@200795|Chloroflexi	200795|Chloroflexi	P	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TLS1_k127_4456148_1	1382306.JNIM01000001_gene1358	1.508e-81	282.0	COG0215@1|root,COG1216@1|root,COG0215@2|Bacteria,COG1216@2|Bacteria,2G5Z0@200795|Chloroflexi	2|Bacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
TLS1_k127_4456148_6	243164.DET0573	1.772e-53	210.0	COG4166@1|root,COG4166@2|Bacteria,2G5TA@200795|Chloroflexi,34CV3@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
TLS1_k127_4456148_8	479434.Sthe_0719	2.517e-38	164.0	COG0308@1|root,COG0308@2|Bacteria,2G6SD@200795|Chloroflexi,27XPY@189775|Thermomicrobia	189775|Thermomicrobia	E	Peptidase MA superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_MA_2
TLS1_k127_4456148_9	1209989.TepiRe1_1245	1.997e-25	116.0	COG3879@1|root,COG3879@2|Bacteria,1V0FG@1239|Firmicutes,24DRC@186801|Clostridia,42G46@68295|Thermoanaerobacterales	186801|Clostridia	S	Bacterial protein of unknown function (DUF881)	-	-	-	-	-	-	-	-	-	-	-	-	DUF881
TLS1_k127_4456148_10	710421.Mycch_2751	4.039e-20	98.0	COG3879@1|root,COG3879@2|Bacteria,2GJ3C@201174|Actinobacteria,233T1@1762|Mycobacteriaceae	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF881)	-	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF881
TLS1_k127_4456148_11	479434.Sthe_0412	1.491e-18	88.0	COG4481@1|root,COG4481@2|Bacteria,2G9W8@200795|Chloroflexi,27YMV@189775|Thermomicrobia	189775|Thermomicrobia	S	Bacterial protein of unknown function (DUF951)	-	-	-	-	-	-	-	-	-	-	-	-	DUF951
TLS1_k127_4456148_4	479434.Sthe_0413	7.272e-60	230.0	COG0477@1|root,COG2814@2|Bacteria,2G8SG@200795|Chloroflexi,27XS0@189775|Thermomicrobia	189775|Thermomicrobia	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS1_k127_4456148_5	273068.TTE0966	1.476e-57	216.0	COG0252@1|root,COG0252@2|Bacteria,1TPP9@1239|Firmicutes,248F3@186801|Clostridia,42G4V@68295|Thermoanaerobacterales	186801|Clostridia	EJ	PFAM Asparaginase glutaminase	ansA	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
TLS1_k127_4456148_0	326427.Cagg_1321	1.975e-99	344.0	COG1574@1|root,COG1574@2|Bacteria,2G5YJ@200795|Chloroflexi,375CQ@32061|Chloroflexia	32061|Chloroflexia	S	PFAM Amidohydrolase 3	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
TLS1_k127_4456148_2	1033730.CAHG01000016_gene335	5.161e-80	286.0	COG1249@1|root,COG1249@2|Bacteria,2GJJK@201174|Actinobacteria,4DNX4@85009|Propionibacteriales	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS1_k127_4456148_3	314230.DSM3645_15870	3.594e-65	239.0	COG0566@1|root,COG0566@2|Bacteria,2IZJR@203682|Planctomycetes	203682|Planctomycetes	H	SpoU rRNA Methylase family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase
TLS1_k127_4456148_7	537013.CLOSTMETH_02881	6.843e-43	162.0	COG1092@1|root,COG1092@2|Bacteria,1TPUD@1239|Firmicutes,2480X@186801|Clostridia,3WGYH@541000|Ruminococcaceae	186801|Clostridia	J	S-adenosylmethionine-dependent methyltransferase	rlmL_1	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
TLS1_k127_4476708_2	1463917.JODC01000005_gene6994	5.45e-39	147.0	2E5FQ@1|root,3307E@2|Bacteria,2INDB@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4476708_0	390989.JOEG01000013_gene2562	1.132e-186	595.0	COG3285@1|root,COG3285@2|Bacteria,2GM0A@201174|Actinobacteria,4D8RM@85008|Micromonosporales	201174|Actinobacteria	L	DNA primase, small subunit	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	-
TLS1_k127_4476708_3	1197906.CAJQ02000023_gene2443	2.26e-35	143.0	COG3795@1|root,COG3795@2|Bacteria,1N32U@1224|Proteobacteria,2UFVV@28211|Alphaproteobacteria,3JYW1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
TLS1_k127_4476708_1	1172179.AUKV01000003_gene7383	8.807e-145	470.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS1_k127_4476708_4	1002340.AFCF01000033_gene3925	1.096e-06	54.0	COG1814@1|root,COG1814@2|Bacteria,1MUZE@1224|Proteobacteria,2TT6M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	membrane	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
TLS1_k127_4481810_5	749414.SBI_02830	6.211e-18	97.0	COG1247@1|root,COG1247@2|Bacteria,2GR9D@201174|Actinobacteria	201174|Actinobacteria	M	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS1_k127_4481810_2	869210.Marky_0686	9.827e-64	228.0	COG3358@1|root,COG3358@2|Bacteria,1WKRG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Protein of unknown function (DUF1684)	-	-	-	ko:K09164	-	-	-	-	ko00000	-	-	-	DUF1684
TLS1_k127_4481810_6	1185876.BN8_01476	0.0003381	48.0	COG1983@1|root,COG1983@2|Bacteria,4NRBJ@976|Bacteroidetes,47QNK@768503|Cytophagia	976|Bacteroidetes	KT	Phage shock protein C, PspC	-	-	-	-	-	-	-	-	-	-	-	-	PspC
TLS1_k127_4481810_0	661478.OP10G_0129	5.005e-136	439.0	COG0005@1|root,COG0005@2|Bacteria	2|Bacteria	F	purine-nucleoside phosphorylase activity	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
TLS1_k127_4481810_4	383372.Rcas_0241	2.014e-33	149.0	COG2141@1|root,COG2141@2|Bacteria,2G8NG@200795|Chloroflexi	200795|Chloroflexi	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS1_k127_4481810_3	266117.Rxyl_1545	2.068e-40	165.0	COG0483@1|root,COG0483@2|Bacteria,2GJQE@201174|Actinobacteria,4CT0C@84995|Rubrobacteria	84995|Rubrobacteria	G	Inositol monophosphatase family	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
TLS1_k127_4481810_1	391625.PPSIR1_15265	5.592e-81	277.0	COG0258@1|root,COG0258@2|Bacteria,1QV40@1224|Proteobacteria,43BZM@68525|delta/epsilon subdivisions,2X7AE@28221|Deltaproteobacteria,2YUE3@29|Myxococcales	28221|Deltaproteobacteria	L	Helix-hairpin-helix class 2 (Pol1 family) motifs	-	-	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
TLS1_k127_4489987_8	1121924.ATWH01000002_gene4031	4.882e-51	190.0	COG0745@1|root,COG0745@2|Bacteria,2GMG9@201174|Actinobacteria,4FN2A@85023|Microbacteriaceae	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS1_k127_4489987_7	1200792.AKYF01000006_gene1406	1.203e-51	201.0	COG5002@1|root,COG5002@2|Bacteria,1TS5K@1239|Firmicutes,4H9Y1@91061|Bacilli,277BU@186822|Paenibacillaceae	91061|Bacilli	T	His Kinase A (phosphoacceptor) domain	ciaH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K14982	ko02020,ko02024,map02020,map02024	M00521	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
TLS1_k127_4489987_14	938278.CAJO01000060_gene1052	1.876e-11	72.0	COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,24QJE@186801|Clostridia	186801|Clostridia	K	Cold shock protein	cspA	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TLS1_k127_4489987_1	290397.Adeh_0965	1.034e-144	471.0	COG0427@1|root,COG0427@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria,2YW0C@29|Myxococcales	28221|Deltaproteobacteria	C	Acetyl-CoA hydrolase/transferase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1
TLS1_k127_4489987_13	1283299.AUKG01000006_gene757	6.684e-12	73.0	COG1042@1|root,COG1042@2|Bacteria,2GKN1@201174|Actinobacteria,4CRR1@84995|Rubrobacteria	84995|Rubrobacteria	C	CoA-binding	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
TLS1_k127_4489987_15	1125863.JAFN01000001_gene1764	1.22e-10	74.0	COG0589@1|root,COG0589@2|Bacteria,1RA7K@1224|Proteobacteria,42V2P@68525|delta/epsilon subdivisions,2WR88@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS1_k127_4489987_4	525904.Tter_2549	6.157e-68	257.0	COG3850@1|root,COG3850@2|Bacteria,2NS42@2323|unclassified Bacteria	2|Bacteria	T	histidine kinase dimerisation and phosphoacceptor region	-	-	2.7.13.3	ko:K03406,ko:K07673,ko:K07675	ko02020,ko02030,map02020,map02030	M00471,M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	GAF_2,HAMP,HATPase_c,HisKA_3,LapD_MoxY_N
TLS1_k127_4489987_5	351607.Acel_0518	1.347e-67	239.0	COG2197@1|root,COG2197@2|Bacteria,2GK4B@201174|Actinobacteria,4ESHE@85013|Frankiales	201174|Actinobacteria	T	Two component transcriptional regulator, LuxR family	devR	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS1_k127_4489987_6	1001240.GY21_19675	4.028e-57	220.0	COG0406@1|root,COG0406@2|Bacteria,2GNRS@201174|Actinobacteria,4FP95@85023|Microbacteriaceae	201174|Actinobacteria	G	Phosphoglycerate mutase family	gpm2	GO:0003674,GO:0003824,GO:0003993,GO:0005488,GO:0005515,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0042802,GO:0042803,GO:0044237,GO:0046983	3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
TLS1_k127_4489987_10	762211.BSTEL_0024	6.799e-28	128.0	COG1704@1|root,COG1704@2|Bacteria,2GPS4@201174|Actinobacteria,4CZE2@85004|Bifidobacteriales	201174|Actinobacteria	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
TLS1_k127_4489987_16	797210.Halxa_2135	5.166e-05	55.0	arCOG06218@1|root,arCOG06218@2157|Archaea,2XVTI@28890|Euryarchaeota,23SSX@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	GIDE
TLS1_k127_4489987_17	871963.Desdi_0983	0.0008417	51.0	2DPQR@1|root,3330J@2|Bacteria,1VF83@1239|Firmicutes,25EKT@186801|Clostridia,2645C@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4489987_12	56107.Cylst_3878	5.194e-21	105.0	COG0204@1|root,COG0204@2|Bacteria,1G1AK@1117|Cyanobacteria,1HMFN@1161|Nostocales	1117|Cyanobacteria	I	PFAM Phospholipid glycerol acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
TLS1_k127_4489987_11	1123320.KB889683_gene2008	5.513e-22	106.0	COG0382@1|root,COG0382@2|Bacteria,2GJT3@201174|Actinobacteria	201174|Actinobacteria	H	Pfam UbiA prenyltransferase	ubiA	-	-	-	-	-	-	-	-	-	-	-	UbiA
TLS1_k127_4489987_9	1028800.RG540_CH40330	2.596e-42	168.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,2TSTN@28211|Alphaproteobacteria,4B7NP@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
TLS1_k127_4489987_3	585531.HMPREF0063_10664	6.077e-71	248.0	COG1192@1|root,COG1192@2|Bacteria,2GJX3@201174|Actinobacteria,4DP0V@85009|Propionibacteriales	201174|Actinobacteria	D	Cellulose biosynthesis protein BcsQ	soj	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009295,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0071944	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
TLS1_k127_4489987_0	485913.Krac_12092	9.96e-240	753.0	COG4799@1|root,COG4799@2|Bacteria,2G5IX@200795|Chloroflexi	200795|Chloroflexi	I	PFAM carboxyl transferase	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
TLS1_k127_4489987_2	383372.Rcas_0979	1.828e-135	447.0	COG4770@1|root,COG4770@2|Bacteria,2GBIE@200795|Chloroflexi,374S0@32061|Chloroflexia	32061|Chloroflexia	I	Carbamoyl-phosphate synthetase large chain domain protein	-	-	6.4.1.4	ko:K01968	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
TLS1_k127_455370_1	357808.RoseRS_0692	3.813e-86	289.0	COG0714@1|root,COG0714@2|Bacteria,2G66D@200795|Chloroflexi,374V5@32061|Chloroflexia	32061|Chloroflexia	S	ATPase associated with various cellular activities, AAA_5	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TLS1_k127_455370_2	1121324.CLIT_12c00370	2.502e-70	270.0	COG0768@1|root,COG0768@2|Bacteria,1TP93@1239|Firmicutes,248KB@186801|Clostridia,25R3P@186804|Peptostreptococcaceae	186801|Clostridia	M	penicillin-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Transpeptidase
TLS1_k127_455370_0	1382356.JQMP01000003_gene2565	9.039e-99	340.0	COG0772@1|root,COG0772@2|Bacteria,2G6NR@200795|Chloroflexi,27Y4C@189775|Thermomicrobia	189775|Thermomicrobia	D	Cell cycle protein	-	-	-	-	-	-	-	-	-	-	-	-	FTSW_RODA_SPOVE
TLS1_k127_455370_4	1128421.JAGA01000002_gene1898	1.795e-22	102.0	COG1716@1|root,COG1716@2|Bacteria,2NRHK@2323|unclassified Bacteria	2|Bacteria	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
TLS1_k127_455370_3	324602.Caur_1989	2.954e-29	127.0	COG1716@1|root,COG1716@2|Bacteria,2G79K@200795|Chloroflexi,37509@32061|Chloroflexia	32061|Chloroflexia	T	PFAM Forkhead-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3662,FHA
TLS1_k127_455370_5	105422.BBPM01000061_gene4427	0.0003295	51.0	COG1933@1|root,COG1933@2|Bacteria,2IH21@201174|Actinobacteria,2NEVT@228398|Streptacidiphilus	201174|Actinobacteria	L	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	DZR
TLS1_k127_4567300_1	35754.JNYJ01000075_gene8654	9.314e-131	449.0	COG1290@1|root,COG1290@2|Bacteria,2GJ1E@201174|Actinobacteria,4DAJX@85008|Micromonosporales	201174|Actinobacteria	C	Cytochrome b	qcrB	-	-	ko:K03891	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_B_N_2
TLS1_k127_4567300_3	525909.Afer_1826	7.342e-63	227.0	COG0723@1|root,COG0723@2|Bacteria,2GIX6@201174|Actinobacteria,4CNF9@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Rieske [2Fe-2S] domain	-	-	-	ko:K03890	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Rieske
TLS1_k127_4567300_5	222534.KB893711_gene4996	2.595e-45	181.0	COG2010@1|root,COG2010@2|Bacteria,2GKUB@201174|Actinobacteria,4ESET@85013|Frankiales	201174|Actinobacteria	C	cytochrome C	qcrC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03889	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrome_CBB3
TLS1_k127_4567300_2	861299.J421_1879	1.155e-109	371.0	COG1252@1|root,COG1252@2|Bacteria,1ZT8C@142182|Gemmatimonadetes	2|Bacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TLS1_k127_4567300_6	485913.Krac_6522	2.166e-20	104.0	COG0607@1|root,COG0607@2|Bacteria	2|Bacteria	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TLS1_k127_4567300_4	1380386.JIAW01000027_gene7113	1.097e-48	188.0	COG0346@1|root,COG0346@2|Bacteria,2IKTR@201174|Actinobacteria,23AED@1762|Mycobacteriaceae	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS1_k127_4567300_0	1150399.AQYK01000001_gene1861	1.688e-144	467.0	COG0526@1|root,COG0526@2|Bacteria,2GKDT@201174|Actinobacteria,4FN75@85023|Microbacteriaceae	201174|Actinobacteria	CO	AhpC/TSA family	dipZ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DsbD
TLS1_k127_4567300_7	479435.Kfla_3685	6.792e-06	48.0	COG1018@1|root,COG1018@2|Bacteria,2HZ81@201174|Actinobacteria,4DQVT@85009|Propionibacteriales	201174|Actinobacteria	C	Oxidoreductase FAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,NAD_binding_1
TLS1_k127_4618567_3	1121472.AQWN01000007_gene1144	6.088e-59	214.0	COG1228@1|root,COG1228@2|Bacteria,1TP2J@1239|Firmicutes,24AGR@186801|Clostridia,260J1@186807|Peptococcaceae	186801|Clostridia	Q	PFAM Amidohydrolase family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
TLS1_k127_4618567_2	1121468.AUBR01000045_gene1801	1.902e-80	291.0	COG3643@1|root,COG3643@2|Bacteria,1TP5T@1239|Firmicutes,24905@186801|Clostridia,42EU0@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM Formiminotransferase	ftcD	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K01746	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000	-	-	-	FTCD,FTCD_N
TLS1_k127_4618567_7	1449044.JMLE01000001_gene3974	3.461e-17	97.0	COG0028@1|root,COG0028@2|Bacteria	2|Bacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6,4.1.3.1	ko:K01637,ko:K01652	ko00290,ko00630,ko00650,ko00660,ko00770,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00290,map00630,map00650,map00660,map00770,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00012,M00019,M00570	R00006,R00014,R00226,R00479,R03050,R04672,R04673,R08648	RC00027,RC00106,RC00311,RC00313,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	Laminin_G_3,PAP2,TPP_enzyme_N
TLS1_k127_4618567_0	1386089.N865_11030	2.075e-281	899.0	COG2374@1|root,COG2374@2|Bacteria,2I2E0@201174|Actinobacteria,4FFZJ@85021|Intrasporangiaceae	201174|Actinobacteria	M	Lamin Tail Domain	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	Big_3_5,Big_5,CW_binding_2,DUF3616,Exo_endo_phos,LTD
TLS1_k127_4618567_10	1123261.AXDW01000007_gene2332	8.095e-06	54.0	COG0346@1|root,COG0346@2|Bacteria,1RGZ8@1224|Proteobacteria,1S66M@1236|Gammaproteobacteria,1X73S@135614|Xanthomonadales	135614|Xanthomonadales	E	Glyoxalase-like domain	-	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS1_k127_4618567_9	40571.JOEA01000020_gene7677	1.006e-07	63.0	COG3153@1|root,COG3153@2|Bacteria,2GNNB@201174|Actinobacteria,4DXW4@85010|Pseudonocardiales	201174|Actinobacteria	S	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS1_k127_4618567_1	867903.ThesuDRAFT_00368	1.462e-152	499.0	COG2986@1|root,COG2986@2|Bacteria,1TPCW@1239|Firmicutes,247XP@186801|Clostridia,3WCEP@538999|Clostridiales incertae sedis	186801|Clostridia	E	Aromatic amino acid lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
TLS1_k127_4618567_4	1234364.AMSF01000087_gene2795	1.837e-45	172.0	COG0586@1|root,COG0586@2|Bacteria,1RGII@1224|Proteobacteria,1S844@1236|Gammaproteobacteria,1XCVR@135614|Xanthomonadales	135614|Xanthomonadales	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TLS1_k127_4618567_5	1089545.KB913037_gene5322	2.656e-34	137.0	COG1846@1|root,COG1846@2|Bacteria,2GJ6W@201174|Actinobacteria	201174|Actinobacteria	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
TLS1_k127_4618567_6	1297742.A176_03062	1.682e-31	134.0	COG1595@1|root,COG1595@2|Bacteria,1N00E@1224|Proteobacteria,432XU@68525|delta/epsilon subdivisions,2WXDM@28221|Deltaproteobacteria,2YVQ7@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS1_k127_4618567_8	1380390.JIAT01000010_gene4390	6.153e-13	75.0	COG2931@1|root,COG2931@2|Bacteria,2GYC8@201174|Actinobacteria	201174|Actinobacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
TLS1_k127_4624284_10	1120950.KB892742_gene3009	1.58e-35	141.0	COG0412@1|root,COG0412@2|Bacteria,2GJMH@201174|Actinobacteria,4DQY9@85009|Propionibacteriales	201174|Actinobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
TLS1_k127_4624284_9	1121468.AUBR01000051_gene1994	1.317e-62	229.0	COG0083@1|root,COG0083@2|Bacteria,1TRWS@1239|Firmicutes,248NA@186801|Clostridia,42G2S@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	-	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS03525	GHMP_kinases_C,GHMP_kinases_N
TLS1_k127_4624284_4	864702.OsccyDRAFT_3660	1.654e-113	389.0	COG0498@1|root,COG0498@2|Bacteria,1G31E@1117|Cyanobacteria,1H8BC@1150|Oscillatoriales	1117|Cyanobacteria	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC	GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008144,GO:0016829,GO:0016835,GO:0016838,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS1_k127_4624284_7	316278.SynRCC307_0723	2.607e-72	258.0	COG0460@1|root,COG0460@2|Bacteria,1G0WN@1117|Cyanobacteria,1GYWW@1129|Synechococcus	1117|Cyanobacteria	E	homoserine dehydrogenase	thrA	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
TLS1_k127_4624284_5	552811.Dehly_1025	7.927e-101	339.0	COG0180@1|root,COG0180@2|Bacteria,2G6CG@200795|Chloroflexi,34CX6@301297|Dehalococcoidia	301297|Dehalococcoidia	J	tRNA synthetases class I (W and Y)	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
TLS1_k127_4624284_13	292459.STH2385	4.542e-18	97.0	COG0628@1|root,COG0628@2|Bacteria,1TQ84@1239|Firmicutes,248FS@186801|Clostridia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS1_k127_4624284_8	926569.ANT_05580	1.003e-70	262.0	COG0496@1|root,COG0496@2|Bacteria,2G6XI@200795|Chloroflexi	200795|Chloroflexi	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
TLS1_k127_4624284_12	1382356.JQMP01000001_gene767	1.899e-29	126.0	COG3576@1|root,COG3576@2|Bacteria,2GBHJ@200795|Chloroflexi,27YES@189775|Thermomicrobia	189775|Thermomicrobia	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS1_k127_4624284_14	1038866.KB902769_gene1727	9.936e-14	78.0	COG3753@1|root,COG3753@2|Bacteria,1N7FF@1224|Proteobacteria,2UI50@28211|Alphaproteobacteria,3JQQU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Bacterial protein of unknown function (DUF937)	-	-	-	-	-	-	-	-	-	-	-	-	DUF937
TLS1_k127_4624284_2	204669.Acid345_1271	1.168e-136	452.0	COG1233@1|root,COG1233@2|Bacteria,3Y3I8@57723|Acidobacteria,2JI78@204432|Acidobacteriia	204432|Acidobacteriia	C	TIGRFAM phytoene desaturase	-	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
TLS1_k127_4624284_0	204669.Acid345_1270	4.885e-241	762.0	COG1233@1|root,COG1233@2|Bacteria,3Y3T3@57723|Acidobacteria,2JME5@204432|Acidobacteriia	204432|Acidobacteriia	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
TLS1_k127_4624284_15	84588.SYNW0214	0.0007654	48.0	COG1487@1|root,COG1487@2|Bacteria,1G98C@1117|Cyanobacteria,1H2BV@1129|Synechococcus	1117|Cyanobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS1_k127_4624284_1	1370121.AUWS01000033_gene4232	1.982e-153	503.0	COG0076@1|root,COG0076@2|Bacteria,2GK3J@201174|Actinobacteria,234CE@1762|Mycobacteriaceae	201174|Actinobacteria	E	decarboxylase	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
TLS1_k127_4624284_3	204669.Acid345_1269	8.162e-124	408.0	COG0404@1|root,COG0404@2|Bacteria,3Y3IU@57723|Acidobacteria,2JI8G@204432|Acidobacteriia	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
TLS1_k127_4624284_11	292459.STH1444	8.386e-32	138.0	COG0454@1|root,COG0456@2|Bacteria,1V6D6@1239|Firmicutes,24KC1@186801|Clostridia	186801|Clostridia	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS1_k127_4624284_6	1449069.JMLO01000004_gene3664	1.488e-90	307.0	COG2141@1|root,COG2141@2|Bacteria,2GKRH@201174|Actinobacteria,4FZAN@85025|Nocardiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS1_k127_4699245_2	525904.Tter_1099	1.12e-55	213.0	COG2856@1|root,COG2856@2|Bacteria,2NQY0@2323|unclassified Bacteria	2|Bacteria	E	Zn peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4699245_0	525263.HMPREF0298_0307	7.366e-138	457.0	COG0018@1|root,COG0018@2|Bacteria,2GKQ3@201174|Actinobacteria,22JYB@1653|Corynebacteriaceae	201174|Actinobacteria	J	Arginyl-tRNA synthetase	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
TLS1_k127_4699245_3	1283284.AZUK01000001_gene2453	7.916e-45	190.0	29W90@1|root,30HUD@2|Bacteria,1R92S@1224|Proteobacteria,1S1CJ@1236|Gammaproteobacteria,1Y5WT@135624|Aeromonadales	135624|Aeromonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4699245_1	1449353.JQMQ01000005_gene1864	2.024e-88	333.0	COG1361@1|root,COG4257@1|root,COG1361@2|Bacteria,COG4257@2|Bacteria,2HERV@201174|Actinobacteria,2NKXW@228398|Streptacidiphilus	201174|Actinobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
TLS1_k127_4699245_4	526227.Mesil_1976	3.701e-05	54.0	COG5624@1|root,COG5624@2|Bacteria,1WJK4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_470471_7	768670.Calni_0266	4.464e-24	115.0	COG0107@1|root,COG0107@2|Bacteria,2GENM@200930|Deferribacteres	200930|Deferribacteres	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TLS1_k127_470471_4	479434.Sthe_0919	1.371e-56	214.0	COG0118@1|root,COG0118@2|Bacteria,2G6FD@200795|Chloroflexi,27Y6F@189775|Thermomicrobia	189775|Thermomicrobia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
TLS1_k127_470471_3	940282.CADQ01000031_gene1961	3.089e-59	219.0	COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,2TTVV@28211|Alphaproteobacteria,2JPDI@204441|Rhodospirillales	204441|Rhodospirillales	E	imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
TLS1_k127_470471_6	1300345.LF41_3060	2.533e-44	180.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1X3SR@135614|Xanthomonadales	135614|Xanthomonadales	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS1_k127_470471_1	326424.FRAAL5004	1.1e-89	326.0	COG0141@1|root,COG0141@2|Bacteria,2GKKA@201174|Actinobacteria,4ERSZ@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1599	Histidinol_dh
TLS1_k127_470471_2	1341155.FSS13T_17230	5.008e-71	253.0	COG0040@1|root,COG0040@2|Bacteria,4NDW8@976|Bacteroidetes,1HWP3@117743|Flavobacteriia,2NTFX@237|Flavobacterium	976|Bacteroidetes	E	ATP phosphoribosyltransferase	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
TLS1_k127_470471_8	1341151.ASZU01000006_gene2819	1.594e-21	101.0	COG4496@1|root,COG4496@2|Bacteria,1VA04@1239|Firmicutes,4HKS8@91061|Bacilli,27C5S@186824|Thermoactinomycetaceae	91061|Bacilli	S	Trp repressor protein	yerC	-	-	-	-	-	-	-	-	-	-	-	Trp_repressor
TLS1_k127_470471_5	357808.RoseRS_3192	1.31e-50	188.0	COG0106@1|root,COG0106@2|Bacteria,2G6EC@200795|Chloroflexi,376JE@32061|Chloroflexia	32061|Chloroflexia	E	TIGRFAM phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TLS1_k127_470471_0	1120985.AUMI01000015_gene1552	1.133e-92	311.0	COG0480@1|root,COG0480@2|Bacteria,1TPWN@1239|Firmicutes,4H1Y3@909932|Negativicutes	909932|Negativicutes	J	elongation factor G	fusA_1	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
TLS1_k127_4776796_2	1033806.HTIA_2121	0.0001219	48.0	COG2730@1|root,arCOG07700@2157|Archaea,arCOG09007@2157|Archaea,2Y2AK@28890|Euryarchaeota,23ZD8@183963|Halobacteria	183963|Halobacteria	G	Cellulase (glycosyl hydrolase family 5)	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase,fn3
TLS1_k127_4776796_1	1123321.KB905827_gene497	6.625e-15	79.0	COG4334@1|root,COG4334@2|Bacteria	2|Bacteria	E	Uncharacterized protein conserved in bacteria (DUF2255)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2255,F420H2_quin_red
TLS1_k127_4776796_0	469371.Tbis_2360	0.0	1105.0	COG2609@1|root,COG2609@2|Bacteria,2GJRE@201174|Actinobacteria,4DXNT@85010|Pseudonocardiales	201174|Actinobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
TLS1_k127_4875953_9	656024.FsymDg_0888	3.412e-10	61.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4ERS8@85013|Frankiales	201174|Actinobacteria	E	aminotransferase class I and II	-	-	2.6.1.1,2.6.1.17,2.6.1.2,2.6.1.66	ko:K00812,ko:K10907,ko:K14260,ko:K14267	ko00220,ko00250,ko00270,ko00290,ko00300,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00290,map00300,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01130,map01210,map01230	M00016	R00258,R00355,R00694,R00734,R00896,R01215,R02433,R02619,R04475,R05052	RC00006,RC00008,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS1_k127_4875953_7	1408424.JHYI01000023_gene4243	3.299e-13	82.0	COG5061@1|root,COG5061@2|Bacteria,1VF12@1239|Firmicutes,4HQ46@91061|Bacilli,1ZD53@1386|Bacillus	91061|Bacilli	OU	Protein of unknown function (DUF3307)	satE	-	-	-	-	-	-	-	-	-	-	-	DUF3307
TLS1_k127_4875953_11	756883.Halar_2719	6.177e-05	53.0	arCOG10295@1|root,arCOG10295@2157|Archaea	2157|Archaea	S	SatD family (SatD)	-	-	-	-	-	-	-	-	-	-	-	-	SatD
TLS1_k127_4875953_4	1906.SFRA_03705	3.907e-55	216.0	COG2072@1|root,COG2072@2|Bacteria,2GNGX@201174|Actinobacteria	201174|Actinobacteria	P	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_3
TLS1_k127_4875953_8	880073.Calab_0980	1.045e-11	73.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
TLS1_k127_4875953_6	926569.ANT_10990	1.096e-20	101.0	COG0664@1|root,COG0664@2|Bacteria,2G92E@200795|Chloroflexi	200795|Chloroflexi	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
TLS1_k127_4875953_0	497964.CfE428DRAFT_0631	1.166e-145	511.0	COG2114@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3903@2|Bacteria,46TZ3@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,NB-ARC
TLS1_k127_4875953_10	1096756.ATKN01000009_gene1102	5.469e-09	64.0	COG3832@1|root,COG3832@2|Bacteria,2IJCI@201174|Actinobacteria	201174|Actinobacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
TLS1_k127_4875953_2	525904.Tter_0028	1.651e-89	311.0	COG1351@1|root,COG1351@2|Bacteria,2NQ7P@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
TLS1_k127_4875953_5	1385519.N801_00340	8.925e-37	151.0	COG0412@1|root,COG0412@2|Bacteria,2GK7H@201174|Actinobacteria,4FFR8@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DLH
TLS1_k127_4875953_3	717605.Theco_1937	1.155e-80	282.0	COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,4HABP@91061|Bacilli,26TPG@186822|Paenibacillaceae	91061|Bacilli	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	punA	-	2.4.2.1,2.4.2.28	ko:K00772,ko:K03783	ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110	M00034	R01402,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
TLS1_k127_4875953_1	1382304.JNIL01000001_gene3015	7.313e-137	445.0	COG2896@1|root,COG2896@2|Bacteria,1TP89@1239|Firmicutes,4HAKQ@91061|Bacilli,279ER@186823|Alicyclobacillaceae	91061|Bacilli	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
TLS1_k127_4883736_14	1128421.JAGA01000004_gene2493	1.613e-26	125.0	COG0308@1|root,COG0308@2|Bacteria,2NPPZ@2323|unclassified Bacteria	2|Bacteria	E	Peptidase family M1 domain	pepN	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
TLS1_k127_4883736_3	298653.Franean1_6800	4.868e-92	323.0	2DB7W@1|root,2Z7P1@2|Bacteria,2GP9W@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4331)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4331
TLS1_k127_4883736_4	512565.AMIS_63690	6.961e-79	269.0	COG1247@1|root,COG1247@2|Bacteria,2I3CR@201174|Actinobacteria,4DDTD@85008|Micromonosporales	201174|Actinobacteria	M	GCN5 family acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS1_k127_4883736_11	240015.ACP_1850	2.673e-36	154.0	COG3662@1|root,COG3662@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2236)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2236,LolB
TLS1_k127_4883736_10	1463885.KL578356_gene9801	4.496e-49	183.0	COG1268@1|root,COG1268@2|Bacteria,2GJ53@201174|Actinobacteria	201174|Actinobacteria	S	BioY protein	bioY	-	-	ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	2.A.88.1,2.A.88.2	-	-	BioY
TLS1_k127_4883736_8	42256.RradSPS_0734	2.274e-68	261.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,2GJTZ@201174|Actinobacteria,4CPJ5@84995|Rubrobacteria	84995|Rubrobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS1_k127_4883736_7	1380390.JIAT01000010_gene4014	1.96e-73	255.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4CPWA@84995|Rubrobacteria	84995|Rubrobacteria	V	PFAM ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS1_k127_4883736_17	292459.STH564	1.025e-19	102.0	COG2340@1|root,COG2340@2|Bacteria,1V6GZ@1239|Firmicutes,24I20@186801|Clostridia	186801|Clostridia	M	PFAM Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP,LysM
TLS1_k127_4883736_9	378806.STAUR_7997	6.283e-63	233.0	2E458@1|root,32Z1A@2|Bacteria,1PAGT@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4883736_0	1123325.JHUV01000008_gene881	1.196e-122	407.0	COG0498@1|root,COG0498@2|Bacteria,2G4SE@200783|Aquificae	200783|Aquificae	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC_1	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS1_k127_4883736_15	1005999.GLGR_1817	1.657e-21	100.0	COG0251@1|root,COG0251@2|Bacteria,1N7U1@1224|Proteobacteria,1SP10@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
TLS1_k127_4883736_2	861299.J421_1634	3.358e-96	332.0	COG3214@1|root,COG3214@2|Bacteria	2|Bacteria	J	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
TLS1_k127_4883736_12	1348657.M622_06505	2.953e-34	135.0	COG3189@1|root,COG3189@2|Bacteria,1MZ7H@1224|Proteobacteria,2VUKU@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
TLS1_k127_4883736_6	330214.NIDE0018	1.01e-73	258.0	COG1018@1|root,COG1018@2|Bacteria,3J196@40117|Nitrospirae	40117|Nitrospirae	C	Oxidoreductase NAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4883736_13	1236902.ANAS01000007_gene3846	1.815e-33	139.0	COG0546@1|root,COG0546@2|Bacteria,2GIU8@201174|Actinobacteria,4EI12@85012|Streptosporangiales	201174|Actinobacteria	S	HAD-hyrolase-like	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS1_k127_4883736_5	485913.Krac_4187	2.97e-77	267.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS1_k127_4883736_1	323097.Nham_1796	1.2e-116	394.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2TRXF@28211|Alphaproteobacteria,3JSVF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	TIGRFAM chromate transporter, chromate ion transporter (CHR) family	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
TLS1_k127_4883736_16	1172188.KB911820_gene3085	7.387e-20	94.0	28RB9@1|root,2ZDQU@2|Bacteria,2GZQK@201174|Actinobacteria,4FIZG@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_492644_2	867845.KI911784_gene3132	7.013e-60	233.0	COG0744@1|root,COG0744@2|Bacteria,2G5ZG@200795|Chloroflexi,3754V@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase, family 51	-	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
TLS1_k127_492644_0	1379270.AUXF01000004_gene3238	6.413e-127	419.0	COG0162@1|root,COG0162@2|Bacteria,1ZT43@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
TLS1_k127_492644_3	266117.Rxyl_2116	2.052e-49	188.0	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,2IKKU@201174|Actinobacteria,4CQAR@84995|Rubrobacteria	84995|Rubrobacteria	E	Histidine biosynthesis bifunctional protein HisIE	hisI	-	3.5.4.19,3.6.1.31	ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH,PRA-PH
TLS1_k127_492644_1	631454.N177_1373	1.531e-73	253.0	COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,2TQXD@28211|Alphaproteobacteria,1JNED@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TLS1_k127_5014404_2	321332.CYB_2524	1.62e-110	365.0	COG0542@1|root,COG0542@2|Bacteria,1G04Z@1117|Cyanobacteria,1GYV5@1129|Synechococcus	1117|Cyanobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
TLS1_k127_5014404_3	1279009.ADICEAN_01182	5.071e-25	114.0	COG0494@1|root,COG0494@2|Bacteria,4NM6C@976|Bacteroidetes,47MQZ@768503|Cytophagia	976|Bacteroidetes	L	pfam nudix	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS1_k127_5014404_6	665571.STHERM_c06100	6.775e-05	53.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	1.14.12.17	ko:K05916	ko05132,map05132	-	-	-	ko00000,ko00001,ko01000	-	-	-	Cupin_2,Globin
TLS1_k127_5014404_0	1382306.JNIM01000001_gene3845	7.774e-145	477.0	COG0138@1|root,COG0138@2|Bacteria,2G5JG@200795|Chloroflexi	200795|Chloroflexi	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
TLS1_k127_5014404_1	869210.Marky_1478	9.419e-122	399.0	COG1494@1|root,COG1494@2|Bacteria,1WI3D@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	TIGRFAM fructose-1,6-bisphosphatase, class II	glpX	-	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
TLS1_k127_5014404_4	644966.Tmar_0139	1.981e-24	118.0	COG0801@1|root,COG0801@2|Bacteria,1V6PR@1239|Firmicutes,249YP@186801|Clostridia,3WDEK@538999|Clostridiales incertae sedis	186801|Clostridia	H	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)	folK	-	2.7.6.3,4.1.2.25	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R03504	RC00002,RC00017,RC00721,RC00943	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB,HPPK
TLS1_k127_5014404_5	292459.STH124	2.572e-17	96.0	COG1920@1|root,COG1920@2|Bacteria,1V86Y@1239|Firmicutes,24K51@186801|Clostridia	186801|Clostridia	S	GTP binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5033825_6	1380370.JIBA01000015_gene171	1.564e-39	151.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4FIR9@85021|Intrasporangiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS1_k127_5033825_4	446466.Cfla_1494	4.395e-44	174.0	COG1522@1|root,COG1522@2|Bacteria,2GP1P@201174|Actinobacteria	201174|Actinobacteria	K	AsnC family	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
TLS1_k127_5033825_5	768671.ThimaDRAFT_2402	5.268e-40	165.0	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,1T54V@1236|Gammaproteobacteria,1X2UH@135613|Chromatiales	135613|Chromatiales	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
TLS1_k127_5033825_2	1123368.AUIS01000006_gene603	1.575e-88	307.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,2NC51@225057|Acidithiobacillales	225057|Acidithiobacillales	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	metZ	-	-	ko:K10764	ko00270,ko00920,ko01100,map00270,map00920,map01100	-	R01288	RC00020,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
TLS1_k127_5033825_3	521393.JH806633_gene1439	3.407e-45	182.0	COG1333@1|root,COG1333@2|Bacteria,2GMGH@201174|Actinobacteria,4D3U7@85005|Actinomycetales	201174|Actinobacteria	O	ResB-like family	-	-	-	ko:K07399	-	-	-	-	ko00000	-	-	-	ResB
TLS1_k127_5033825_7	926550.CLDAP_29550	5.752e-15	90.0	COG3835@1|root,COG3835@2|Bacteria	2|Bacteria	KT	positive regulation of transcription, DNA-templated	-	-	-	ko:K09684	-	-	-	-	ko00000,ko03000	-	-	-	GAF_2,HTH_30,PucR
TLS1_k127_5033825_0	357808.RoseRS_2983	2.391e-203	644.0	COG0174@1|root,COG0174@2|Bacteria,2G61M@200795|Chloroflexi,376YP@32061|Chloroflexia	32061|Chloroflexia	E	PFAM glutamine synthetase catalytic region	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
TLS1_k127_5033825_1	1382356.JQMP01000003_gene1524	3.46e-180	594.0	COG0174@1|root,COG0174@2|Bacteria,2G5U2@200795|Chloroflexi,27XSZ@189775|Thermomicrobia	189775|Thermomicrobia	E	glutamine synthetase	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
TLS1_k127_5120819_1	106370.Francci3_3907	6.778e-44	167.0	COG1695@1|root,COG1695@2|Bacteria,2ISJ2@201174|Actinobacteria,4EW22@85013|Frankiales	201174|Actinobacteria	K	Virulence activator alpha C-term	-	-	-	-	-	-	-	-	-	-	-	-	PadR,Vir_act_alpha_C
TLS1_k127_5120819_2	1122138.AQUZ01000047_gene100	1.614e-30	130.0	COG5485@1|root,COG5485@2|Bacteria,2HPCH@201174|Actinobacteria,4DSK3@85009|Propionibacteriales	201174|Actinobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
TLS1_k127_5120819_3	521393.JH806634_gene2192	3.707e-14	78.0	COG2026@1|root,COG2026@2|Bacteria,2IRES@201174|Actinobacteria,4D63R@85005|Actinomycetales	201174|Actinobacteria	DJ	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
TLS1_k127_5120819_0	68219.JNXI01000006_gene2070	1.903e-54	203.0	2ECD7@1|root,316NQ@2|Bacteria,2IBCQ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5120819_5	680198.SCAB_65361	3.951e-05	53.0	COG1404@1|root,COG1404@2|Bacteria,2GKJR@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
TLS1_k127_5120819_4	1123319.AUBE01000029_gene5160	6.782e-10	65.0	COG1404@1|root,COG1404@2|Bacteria,2GKJR@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
TLS1_k127_5126696_4	797515.HMPREF9103_03193	4.463e-07	52.0	COG0047@1|root,COG0047@2|Bacteria,1TP1B@1239|Firmicutes,4HAKZ@91061|Bacilli,3F48D@33958|Lactobacillaceae	91061|Bacilli	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	GO:0003674,GO:0003824,GO:0004642,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
TLS1_k127_5126696_0	264732.Moth_2048	1.826e-212	688.0	COG0046@1|root,COG0046@2|Bacteria,1TPAS@1239|Firmicutes,247W2@186801|Clostridia,42F8R@68295|Thermoanaerobacterales	186801|Clostridia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
TLS1_k127_5126696_1	656024.FsymDg_0273	9.364e-154	501.0	COG0034@1|root,COG0034@2|Bacteria,2GK6I@201174|Actinobacteria,4ERIS@85013|Frankiales	201174|Actinobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0008150,GO:0040007	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
TLS1_k127_5126696_3	1173028.ANKO01000106_gene363	5.756e-87	318.0	COG0150@1|root,COG0150@2|Bacteria,1G1WY@1117|Cyanobacteria,1H8GW@1150|Oscillatoriales	1117|Cyanobacteria	F	PFAM AIR synthase related protein, N-terminal domain	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
TLS1_k127_5126696_2	562970.Btus_0822	1.986e-90	322.0	COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,4H9YY@91061|Bacilli,277WS@186823|Alicyclobacillaceae	91061|Bacilli	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
TLS1_k127_5161983_3	1341679.P253_02919	3.501e-19	96.0	COG0563@1|root,COG0563@2|Bacteria,1N0HQ@1224|Proteobacteria,1S4ZC@1236|Gammaproteobacteria,3NSSK@468|Moraxellaceae	1236|Gammaproteobacteria	F	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5161983_4	446466.Cfla_1370	1.045e-06	55.0	COG0563@1|root,COG0563@2|Bacteria,2IGX9@201174|Actinobacteria,4F1IT@85016|Cellulomonadaceae	201174|Actinobacteria	F	adenylate kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_33,SKI
TLS1_k127_5161983_1	656024.FsymDg_3257	1.693e-48	184.0	COG0647@1|root,COG0647@2|Bacteria,2GK7V@201174|Actinobacteria,4ESEC@85013|Frankiales	201174|Actinobacteria	G	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
TLS1_k127_5161983_0	1184609.KILIM_004_00120	6.402e-65	233.0	COG0755@1|root,COG0755@2|Bacteria,2GJR1@201174|Actinobacteria,4F6E4@85018|Dermatophilaceae	201174|Actinobacteria	O	Cytochrome C assembly protein	resC	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
TLS1_k127_5161983_2	211114.JOEF01000033_gene1151	3.983e-43	168.0	COG1075@1|root,COG1075@2|Bacteria,2HS4E@201174|Actinobacteria,4ECBM@85010|Pseudonocardiales	201174|Actinobacteria	S	Lecithin:cholesterol acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5205395_1	370438.PTH_0671	7.873e-20	96.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia,262RV@186807|Peptococcaceae	186801|Clostridia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS1_k127_5205395_2	1894.JOER01000123_gene6318	8.955e-16	91.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
TLS1_k127_5205395_3	97096.XP_007798560.1	2.124e-11	76.0	COG0823@1|root,2QPTW@2759|Eukaryota,38RVS@33154|Opisthokonta,3NZ8B@4751|Fungi,3QSE5@4890|Ascomycota,218QP@147550|Sordariomycetes	4751|Fungi	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
TLS1_k127_5205395_0	298655.KI912266_gene4207	7.975e-61	220.0	COG3324@1|root,COG3324@2|Bacteria,2GJFC@201174|Actinobacteria	201174|Actinobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS1_k127_5207729_8	316274.Haur_0377	2.308e-55	206.0	COG0035@1|root,COG0035@2|Bacteria,2G6CS@200795|Chloroflexi,3754Q@32061|Chloroflexia	32061|Chloroflexia	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	-	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
TLS1_k127_5207729_9	373903.Hore_01750	1.511e-47	187.0	COG4448@1|root,COG4448@2|Bacteria,1TRWI@1239|Firmicutes,24CUE@186801|Clostridia,3WBDN@53433|Halanaerobiales	186801|Clostridia	E	L-asparaginase II	-	-	-	-	-	-	-	-	-	-	-	-	Asparaginase_II
TLS1_k127_5207729_13	471853.Bcav_1749	1.783e-06	60.0	COG0484@1|root,COG0484@2|Bacteria,2GK69@201174|Actinobacteria	201174|Actinobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
TLS1_k127_5207729_11	521098.Aaci_2086	4.765e-32	144.0	COG1321@1|root,COG1321@2|Bacteria,1V4V7@1239|Firmicutes,4HG88@91061|Bacilli	91061|Bacilli	K	domain protein	sirR	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
TLS1_k127_5207729_2	644966.Tmar_0077	1.019e-133	443.0	COG0008@1|root,COG1384@1|root,COG0008@2|Bacteria,COG1384@2|Bacteria,1TPJC@1239|Firmicutes,2482P@186801|Clostridia,3WCIN@538999|Clostridiales incertae sedis	186801|Clostridia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
TLS1_k127_5207729_7	1449049.JONW01000005_gene1921	7.822e-56	217.0	COG3510@1|root,COG3510@2|Bacteria,1MWJ8@1224|Proteobacteria,2U3D6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	cephalosporin hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	CmcI
TLS1_k127_5207729_6	796606.BMMGA3_07020	2.824e-59	215.0	COG3510@1|root,COG3510@2|Bacteria,1V88X@1239|Firmicutes,4HK2A@91061|Bacilli,1ZMUG@1386|Bacillus	91061|Bacilli	V	Cephalosporin hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	CmcI
TLS1_k127_5207729_5	552811.Dehly_1189	4.68e-74	255.0	COG0745@1|root,COG0745@2|Bacteria,2G6A5@200795|Chloroflexi,34D9D@301297|Dehalococcoidia	200795|Chloroflexi	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS1_k127_5207729_3	246194.CHY_0596	2.064e-106	358.0	COG0306@1|root,COG0306@2|Bacteria,1TQ3D@1239|Firmicutes,247ZC@186801|Clostridia,42F2R@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM phosphate transporter	pit	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
TLS1_k127_5207729_0	926550.CLDAP_15630	1.084e-188	606.0	COG0442@1|root,COG0442@2|Bacteria,2G5Q6@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
TLS1_k127_5207729_12	1217720.ALOX01000054_gene2205	7.936e-08	64.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,2TR01@28211|Alphaproteobacteria,2JQKE@204441|Rhodospirillales	204441|Rhodospirillales	O	Molecular chaperone	cbpA	-	-	-	-	-	-	-	-	-	-	-	DnaJ,DnaJ_C
TLS1_k127_5207729_1	903818.KI912268_gene3392	1.354e-168	546.0	COG0513@1|root,COG0513@2|Bacteria,3Y2M6@57723|Acidobacteria	57723|Acidobacteria	L	DEAD DEAH box helicase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
TLS1_k127_5207729_4	263358.VAB18032_20120	5.079e-87	294.0	COG0745@1|root,COG0745@2|Bacteria,2GJRR@201174|Actinobacteria,4DCMD@85008|Micromonosporales	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS1_k127_5224918_4	635013.TherJR_2824	2.386e-45	183.0	COG0438@1|root,COG0438@2|Bacteria,1UHSF@1239|Firmicutes,25EAY@186801|Clostridia,261D9@186807|Peptococcaceae	186801|Clostridia	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS1_k127_5224918_8	1254432.SCE1572_11880	2.097e-30	135.0	COG0500@1|root,COG5653@1|root,COG2226@2|Bacteria,COG5653@2|Bacteria,1N7WR@1224|Proteobacteria,42VU5@68525|delta/epsilon subdivisions,2WSGU@28221|Deltaproteobacteria,2YXKC@29|Myxococcales	28221|Deltaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
TLS1_k127_5224918_0	479435.Kfla_1557	2.003e-131	451.0	COG0421@1|root,COG0421@2|Bacteria,2HZ8A@201174|Actinobacteria,4DR1S@85009|Propionibacteriales	201174|Actinobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
TLS1_k127_5224918_1	706587.Desti_5503	9.553e-81	297.0	COG0421@1|root,COG4262@1|root,COG0421@2|Bacteria,COG4262@2|Bacteria,1QX9D@1224|Proteobacteria,42Q62@68525|delta/epsilon subdivisions,2WMHX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Spermine spermidine synthase	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
TLS1_k127_5224918_15	272560.BPSS2183	0.000175	53.0	2CIPC@1|root,2Z9HB@2|Bacteria,1R3W8@1224|Proteobacteria,2VZKZ@28216|Betaproteobacteria,1K4V9@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
TLS1_k127_5224918_7	502025.Hoch_2176	6.652e-35	149.0	COG1807@1|root,COG1807@2|Bacteria,1Q2FK@1224|Proteobacteria,4381I@68525|delta/epsilon subdivisions,2X3BM@28221|Deltaproteobacteria,2YUUG@29|Myxococcales	28221|Deltaproteobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5224918_14	1282362.AEAC466_12630	1.757e-07	63.0	2CIPC@1|root,2Z9HB@2|Bacteria,1R3W8@1224|Proteobacteria,2TST7@28211|Alphaproteobacteria,2KH7X@204458|Caulobacterales	204458|Caulobacterales	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
TLS1_k127_5224918_5	309801.trd_1535	1.573e-37	152.0	COG0463@1|root,COG0463@2|Bacteria,2G6GT@200795|Chloroflexi,27XWJ@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS1_k127_5224918_11	1449976.KALB_1326	1.532e-09	69.0	COG5650@1|root,COG5650@2|Bacteria,2GJBC@201174|Actinobacteria,4E2EW@85010|Pseudonocardiales	201174|Actinobacteria	S	Glycosyltransferase family 87	-	GO:0000026,GO:0000030,GO:0003674,GO:0003824,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0070085,GO:0071704,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	ko:K13671	-	-	-	-	ko00000,ko01000,ko01003	-	GT87	-	GT87
TLS1_k127_5224918_3	1380370.JIBA01000003_gene2736	7.679e-46	183.0	2F7A3@1|root,33ZRB@2|Bacteria,2IRS4@201174|Actinobacteria,4FIVD@85021|Intrasporangiaceae	201174|Actinobacteria	S	Pfam:DUF2029	-	-	-	-	-	-	-	-	-	-	-	-	GT87
TLS1_k127_5224918_12	298654.FraEuI1c_2450	1.643e-08	68.0	2DF97@1|root,2ZQZA@2|Bacteria	2|Bacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
TLS1_k127_5224918_13	1121362.A605_09560	7.326e-08	65.0	COG5650@1|root,COG5650@2|Bacteria,2GJBC@201174|Actinobacteria,22KGG@1653|Corynebacteriaceae	201174|Actinobacteria	S	Glycosyltransferase family 87	-	GO:0000026,GO:0000030,GO:0003674,GO:0003824,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0070085,GO:0071704,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	ko:K13671	-	-	-	-	ko00000,ko01000,ko01003	-	GT87	-	GT87
TLS1_k127_5224918_10	316274.Haur_3825	1.121e-09	71.0	COG1807@1|root,COG1807@2|Bacteria,2GAAY@200795|Chloroflexi,374TV@32061|Chloroflexia	32061|Chloroflexia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS1_k127_5224918_6	644966.Tmar_1215	1.25e-36	161.0	COG4585@1|root,COG4585@2|Bacteria,1TQI3@1239|Firmicutes,249R9@186801|Clostridia,3WDR4@538999|Clostridiales incertae sedis	186801|Clostridia	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	degS	-	2.7.13.3	ko:K07777	ko02020,map02020	M00478	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DegS,HATPase_c,HisKA_3
TLS1_k127_5224918_2	525904.Tter_0799	1.407e-71	252.0	COG2197@1|root,COG2197@2|Bacteria,2NQFJ@2323|unclassified Bacteria	2|Bacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS1_k127_5241975_3	65497.JODV01000001_gene3604	3.057e-31	141.0	COG1234@1|root,COG1234@2|Bacteria,2GMEX@201174|Actinobacteria,4DYEQ@85010|Pseudonocardiales	201174|Actinobacteria	S	Beta-lactamase	yhfI	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TLS1_k127_5241975_4	357808.RoseRS_3810	1.499e-30	128.0	COG1595@1|root,COG1595@2|Bacteria,2G6X7@200795|Chloroflexi,375U2@32061|Chloroflexia	32061|Chloroflexia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4
TLS1_k127_5241975_5	1303518.CCALI_02006	4.077e-30	132.0	COG1387@1|root,COG1387@2|Bacteria	2|Bacteria	E	zinc ion binding	-	GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP,PHP_C
TLS1_k127_5241975_0	997346.HMPREF9374_0644	8.596e-153	494.0	COG0156@1|root,COG0156@2|Bacteria,1TPUX@1239|Firmicutes,4HAH3@91061|Bacilli,27B3G@186824|Thermoactinomycetaceae	91061|Bacilli	E	Cys/Met metabolism PLP-dependent enzyme	kbl	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS1_k127_5241975_1	639030.JHVA01000001_gene52	8.609e-150	490.0	COG1063@1|root,COG1063@2|Bacteria,3Y3KU@57723|Acidobacteria,2JIQ4@204432|Acidobacteriia	204432|Acidobacteriia	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS1_k127_5241975_2	309800.C498_01190	7.252e-61	220.0	COG0179@1|root,arCOG00235@2157|Archaea,2XT1S@28890|Euryarchaeota,23S3T@183963|Halobacteria	183963|Halobacteria	Q	COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
TLS1_k127_5283536_7	1489678.RDMS_10700	4.595e-25	111.0	COG4586@1|root,COG4586@2|Bacteria,1WJ1U@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS1_k127_5283536_4	316274.Haur_0901	1.193e-66	234.0	COG1011@1|root,COG1011@2|Bacteria,2G916@200795|Chloroflexi,377HS@32061|Chloroflexia	32061|Chloroflexia	S	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	3.8.1.2	ko:K01560,ko:K07025	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS1_k127_5283536_1	35754.JNYJ01000007_gene2806	8.144e-111	400.0	COG0312@1|root,COG0312@2|Bacteria,2GZPS@201174|Actinobacteria,4D8XK@85008|Micromonosporales	201174|Actinobacteria	S	peptidase U62, modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
TLS1_k127_5283536_0	35754.JNYJ01000007_gene2807	1.75e-215	682.0	COG0312@1|root,COG0312@2|Bacteria,2GJ4E@201174|Actinobacteria,4DBR6@85008|Micromonosporales	201174|Actinobacteria	S	peptidase U62, modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
TLS1_k127_5283536_9	1394178.AWOO02000033_gene8495	2.89e-06	57.0	2ASGX@1|root,31HX4@2|Bacteria,2IJVE@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5283536_2	477641.MODMU_0229	9.413e-89	310.0	COG0477@1|root,COG2814@2|Bacteria,2GKHG@201174|Actinobacteria,4ESY5@85013|Frankiales	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
TLS1_k127_5283536_8	926560.KE387023_gene1206	1.489e-17	87.0	COG5649@1|root,COG5649@2|Bacteria	2|Bacteria	E	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
TLS1_k127_5283536_5	479434.Sthe_0397	4.042e-40	160.0	COG1959@1|root,COG1959@2|Bacteria,2G8ZH@200795|Chloroflexi,27YCQ@189775|Thermomicrobia	189775|Thermomicrobia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
TLS1_k127_5283536_3	1121085.AUCI01000006_gene1497	1.063e-79	282.0	COG0396@1|root,COG0396@2|Bacteria,1TQ98@1239|Firmicutes,4HAD9@91061|Bacilli,1ZAW4@1386|Bacillus	91061|Bacilli	O	COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
TLS1_k127_5283536_6	1385512.N784_07995	3.005e-26	122.0	COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,4HA6Z@91061|Bacilli,2Y96P@289201|Pontibacillus	91061|Bacilli	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
TLS1_k127_5311981_13	298653.Franean1_6462	3.467e-31	139.0	2DM8J@1|root,32695@2|Bacteria,2I561@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5311981_16	1379270.AUXF01000005_gene382	1.385e-06	61.0	COG1295@1|root,COG1295@2|Bacteria,1ZTHX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS1_k127_5311981_14	666681.M301_2542	1.446e-09	66.0	COG2331@1|root,COG2331@2|Bacteria,1N6Q9@1224|Proteobacteria,2VTX5@28216|Betaproteobacteria,2KN44@206350|Nitrosomonadales	206350|Nitrosomonadales	S	regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
TLS1_k127_5311981_3	926569.ANT_28210	6.089e-154	507.0	COG0366@1|root,COG0366@2|Bacteria,2G5NW@200795|Chloroflexi	200795|Chloroflexi	G	SMART alpha amylase catalytic sub domain	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459,Malt_amylase_C
TLS1_k127_5311981_10	649638.Trad_1980	1.831e-77	273.0	COG1609@1|root,COG1609@2|Bacteria,1WMBZ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	PFAM Bacterial regulatory proteins, lacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
TLS1_k127_5311981_7	1463887.KL589986_gene2992	7.836e-100	340.0	COG1653@1|root,COG1653@2|Bacteria,2GJXB@201174|Actinobacteria	201174|Actinobacteria	G	ABC transporter substrate-binding protein	-	-	-	ko:K10232	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	SBP_bac_1
TLS1_k127_5311981_5	744872.Spica_0828	4.128e-104	348.0	COG1175@1|root,COG1175@2|Bacteria,2J5SW@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025,ko:K10233	ko02010,map02010	M00201,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1
TLS1_k127_5311981_8	316274.Haur_1178	2.749e-98	329.0	COG0395@1|root,COG0395@2|Bacteria,2G82A@200795|Chloroflexi,375TC@32061|Chloroflexia	32061|Chloroflexia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K10234	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1
TLS1_k127_5311981_0	311424.DhcVS_372	1.009e-252	811.0	COG0525@1|root,COG0525@2|Bacteria,2G5VS@200795|Chloroflexi,34D5F@301297|Dehalococcoidia	301297|Dehalococcoidia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
TLS1_k127_5311981_1	1246995.AFR_33595	1.285e-246	793.0	COG2909@1|root,COG2909@2|Bacteria,2IBVA@201174|Actinobacteria,4DM2F@85008|Micromonosporales	201174|Actinobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS1_k127_5311981_12	479434.Sthe_3033	1.571e-47	179.0	COG0500@1|root,COG2226@2|Bacteria,2G8IB@200795|Chloroflexi	200795|Chloroflexi	Q	PFAM Methyltransferase type 12	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS1_k127_5311981_4	1449976.KALB_2067	2.255e-139	451.0	COG0451@1|root,COG0451@2|Bacteria,2I2ZM@201174|Actinobacteria	201174|Actinobacteria	M	epimerase dehydratase	-	-	4.1.1.35,4.2.1.46	ko:K01710,ko:K08678,ko:K21211	ko00520,ko00521,ko00523,ko00525,ko01055,ko01059,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01059,map01100,map01130	M00361,M00793	R01384,R06513,R11430	RC00402,RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
TLS1_k127_5311981_6	1449976.KALB_2068	8.018e-101	351.0	COG1208@1|root,COG1208@2|Bacteria,2GKTE@201174|Actinobacteria,4E1A8@85010|Pseudonocardiales	201174|Actinobacteria	JM	Nucleotidyl transferase	mpg2	-	-	ko:K21210	ko01059,ko01130,map01059,map01130	-	R11429	RC00002	ko00000,ko00001	-	-	-	CBS,NTP_transferase
TLS1_k127_5311981_11	103733.JNYO01000014_gene3774	2.832e-62	237.0	COG0451@1|root,COG0451@2|Bacteria,2GM24@201174|Actinobacteria,4E3J1@85010|Pseudonocardiales	201174|Actinobacteria	GM	GDP-mannose 4,6 dehydratase	-	-	-	ko:K21214	ko01059,ko01130,map01059,map01130	-	R11433	RC00182	ko00000,ko00001	-	-	-	Epimerase
TLS1_k127_5311981_15	1123322.KB904691_gene4316	1.726e-08	66.0	COG0438@1|root,COG0438@2|Bacteria,2GNIU@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS1_k127_5311981_2	1382306.JNIM01000001_gene3912	5.179e-183	583.0	COG1219@1|root,COG1219@2|Bacteria,2G661@200795|Chloroflexi	200795|Chloroflexi	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
TLS1_k127_5311981_9	1121405.dsmv_3105	8.509e-79	270.0	COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,42MFU@68525|delta/epsilon subdivisions,2WK74@28221|Deltaproteobacteria,2MJ0K@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
TLS1_k127_5346341_1	479434.Sthe_0441	2.827e-258	820.0	COG0542@1|root,COG0542@2|Bacteria,2G5QU@200795|Chloroflexi,27XEJ@189775|Thermomicrobia	189775|Thermomicrobia	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
TLS1_k127_5346341_7	926550.CLDAP_07360	2.631e-68	245.0	COG0484@1|root,COG0484@2|Bacteria,2G61V@200795|Chloroflexi	200795|Chloroflexi	O	Heat shock protein DnaJ domain protein	-	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
TLS1_k127_5346341_0	555088.DealDRAFT_1048	6.509e-273	863.0	COG0466@1|root,COG0466@2|Bacteria,1TNYG@1239|Firmicutes,247SH@186801|Clostridia,42JPA@68298|Syntrophomonadaceae	186801|Clostridia	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
TLS1_k127_5346341_17	1158318.ATXC01000001_gene205	3.441e-20	96.0	COG0789@1|root,COG0789@2|Bacteria,2G4AP@200783|Aquificae	200783|Aquificae	K	helix_turn_helix, mercury resistance	-	-	-	ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
TLS1_k127_5346341_13	357808.RoseRS_0197	8.47e-32	133.0	COG0071@1|root,COG0071@2|Bacteria,2G71M@200795|Chloroflexi,375U7@32061|Chloroflexia	32061|Chloroflexia	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
TLS1_k127_5346341_10	525904.Tter_0806	3.298e-57	209.0	COG0569@1|root,COG0569@2|Bacteria,2NPN3@2323|unclassified Bacteria	2|Bacteria	P	TrkA-C domain	trkA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
TLS1_k127_5346341_14	1382306.JNIM01000001_gene386	1.895e-30	136.0	COG0569@1|root,COG0569@2|Bacteria,2G71A@200795|Chloroflexi	200795|Chloroflexi	C	PFAM TrkA-N domain protein	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_N
TLS1_k127_5346341_18	552811.Dehly_1509	7.233e-19	96.0	COG0589@1|root,COG0589@2|Bacteria,2G7D7@200795|Chloroflexi,34DAT@301297|Dehalococcoidia	301297|Dehalococcoidia	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS1_k127_5346341_2	871968.DESME_13520	2.754e-151	503.0	COG0531@1|root,COG0531@2|Bacteria,1TQE1@1239|Firmicutes,249N1@186801|Clostridia,260S4@186807|Peptococcaceae	186801|Clostridia	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
TLS1_k127_5346341_9	324602.Caur_3801	2.29e-60	216.0	COG0639@1|root,COG0639@2|Bacteria,2G6GC@200795|Chloroflexi,375HP@32061|Chloroflexia	32061|Chloroflexia	T	PFAM metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
TLS1_k127_5346341_15	477974.Daud_2231	1.724e-29	128.0	COG0357@1|root,COG0357@2|Bacteria,1TPBT@1239|Firmicutes,247WM@186801|Clostridia,261UV@186807|Peptococcaceae	186801|Clostridia	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
TLS1_k127_5346341_11	443143.GM18_0237	1.046e-37	162.0	COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,43CC6@68525|delta/epsilon subdivisions,2X7N2@28221|Deltaproteobacteria,43UI6@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA
TLS1_k127_5346341_16	1382304.JNIL01000001_gene43	7.32e-21	101.0	COG1937@1|root,COG1937@2|Bacteria,1VEF5@1239|Firmicutes,4HKJV@91061|Bacilli	91061|Bacilli	S	Transcriptional regulator	csoR	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
TLS1_k127_5346341_12	671143.DAMO_2813	5.57e-35	141.0	COG1102@1|root,COG1102@2|Bacteria,2NRB0@2323|unclassified Bacteria	2|Bacteria	F	Cytidylate kinase-like family	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Cytidylate_kin2,GAF_2,Pribosyltran
TLS1_k127_5346341_8	580327.Tthe_0360	1.059e-67	235.0	COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,24FR4@186801|Clostridia,42G9G@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
TLS1_k127_5346341_3	1128421.JAGA01000002_gene1298	1.713e-101	335.0	COG0410@1|root,COG0410@2|Bacteria,2NNXF@2323|unclassified Bacteria	2|Bacteria	E	ABC transporter	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
TLS1_k127_5346341_5	357808.RoseRS_2978	2.15e-93	320.0	COG0411@1|root,COG0411@2|Bacteria,2G5W6@200795|Chloroflexi,374Z9@32061|Chloroflexia	32061|Chloroflexia	P	PFAM ABC transporter related	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TLS1_k127_5346341_6	525904.Tter_0587	1.193e-77	282.0	COG4177@1|root,COG4177@2|Bacteria,2NPMP@2323|unclassified Bacteria	2|Bacteria	U	Branched-chain amino acid transport system / permease component	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS1_k127_5346341_4	1283299.AUKG01000004_gene1186	2.092e-99	332.0	COG0559@1|root,COG0559@2|Bacteria,2GMAY@201174|Actinobacteria,4CPRG@84995|Rubrobacteria	84995|Rubrobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997,ko:K11956	ko02010,ko02024,map02010,map02024	M00237,M00322	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.2,3.A.1.4.6	-	-	BPD_transp_2
TLS1_k127_5348788_4	1445613.JALM01000020_gene4722	3.101e-67	240.0	COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,4E3AX@85010|Pseudonocardiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS1_k127_5348788_3	1123023.JIAI01000003_gene2648	1.516e-71	258.0	COG1024@1|root,COG1024@2|Bacteria,2GJW5@201174|Actinobacteria,4E1EZ@85010|Pseudonocardiales	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS1_k127_5348788_0	1123023.JIAI01000003_gene2647	1.015e-210	680.0	COG4670@1|root,COG4670@2|Bacteria	2|Bacteria	I	ketone body catabolic process	-	-	2.8.3.1	ko:K01026	ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120	-	R00928,R01449,R05508	RC00012,RC00014,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
TLS1_k127_5348788_2	1123023.JIAI01000003_gene2646	2.558e-74	259.0	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS1_k127_5348788_6	365044.Pnap_3437	8.707e-34	149.0	COG0329@1|root,COG0329@2|Bacteria,1MWAH@1224|Proteobacteria,2VH30@28216|Betaproteobacteria,4AD2X@80864|Comamonadaceae	28216|Betaproteobacteria	EM	Belongs to the DapA family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
TLS1_k127_5348788_1	485913.Krac_2428	6.9e-75	270.0	COG1609@1|root,COG1609@2|Bacteria,2G8EJ@200795|Chloroflexi	200795|Chloroflexi	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
TLS1_k127_5348788_5	345341.KUTG_03655	1.049e-48	176.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4DZDT@85010|Pseudonocardiales	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	xylC	-	1.2.1.28	ko:K00141	ko00622,ko00623,ko00627,ko01100,ko01120,ko01220,map00622,map00623,map00627,map01100,map01120,map01220	M00537,M00538	R01293,R01419,R05289,R05663,R05664,R07667	RC00075	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS1_k127_5356554_19	1382356.JQMP01000003_gene1782	0.0004302	48.0	COG5662@1|root,COG5662@2|Bacteria,2G9EH@200795|Chloroflexi,27YQY@189775|Thermomicrobia	189775|Thermomicrobia	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5356554_10	326427.Cagg_2227	2.579e-37	149.0	COG1595@1|root,COG1595@2|Bacteria,2G6MG@200795|Chloroflexi,375K5@32061|Chloroflexia	32061|Chloroflexia	K	PFAM sigma-70 region 2 domain protein	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS1_k127_5356554_17	1121946.AUAX01000036_gene1923	4.223e-10	71.0	2DPD0@1|root,331J4@2|Bacteria,2IFZU@201174|Actinobacteria,4DCU1@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5356554_7	215803.DB30_0292	2.071e-59	211.0	COG2050@1|root,COG2050@2|Bacteria,1RBPE@1224|Proteobacteria,42RKY@68525|delta/epsilon subdivisions,2WNSM@28221|Deltaproteobacteria,2YXUH@29|Myxococcales	28221|Deltaproteobacteria	Q	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS1_k127_5356554_12	1267535.KB906767_gene3861	7.056e-31	130.0	COG4103@1|root,COG4103@2|Bacteria	2|Bacteria	T	Tellurite resistance protein TerB	-	-	-	-	-	-	-	-	-	-	-	-	TerB
TLS1_k127_5356554_0	264732.Moth_1872	0.0	1045.0	COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,42EPB@68295|Thermoanaerobacterales	186801|Clostridia	L	TIGRFAM DNA polymerase III, alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
TLS1_k127_5356554_16	357808.RoseRS_4550	1.871e-14	89.0	COG3502@1|root,COG3502@2|Bacteria,2G9SI@200795|Chloroflexi,3760N@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function (DUF952)	-	-	-	-	-	-	-	-	-	-	-	-	DUF952
TLS1_k127_5356554_18	298655.KI912266_gene2423	7.749e-09	70.0	2DRPS@1|root,33CHR@2|Bacteria,2GXSD@201174|Actinobacteria,4EX0H@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5356554_15	1171373.PACID_17860	3.472e-18	97.0	COG3824@1|root,COG3824@2|Bacteria,2IKXW@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
TLS1_k127_5356554_14	1463841.JOIR01000006_gene4695	1.027e-25	118.0	COG1670@1|root,COG1670@2|Bacteria,2IGHV@201174|Actinobacteria	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS1_k127_5356554_11	1131269.AQVV01000002_gene1246	1.94e-31	134.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
TLS1_k127_5356554_8	1386089.N865_13880	5.301e-58	211.0	COG0596@1|root,COG0596@2|Bacteria,2GNFU@201174|Actinobacteria,4FHK7@85021|Intrasporangiaceae	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS1_k127_5356554_9	383372.Rcas_1631	1.115e-54	214.0	COG1744@1|root,COG1744@2|Bacteria,2G6UB@200795|Chloroflexi,375H7@32061|Chloroflexia	32061|Chloroflexia	M	PFAM basic membrane lipoprotein	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
TLS1_k127_5356554_1	926569.ANT_27890	1.651e-178	582.0	COG3845@1|root,COG3845@2|Bacteria,2G625@200795|Chloroflexi	200795|Chloroflexi	S	PFAM ABC transporter related	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
TLS1_k127_5356554_6	357808.RoseRS_1319	7.143e-69	248.0	COG4603@1|root,COG4603@2|Bacteria,2G6MU@200795|Chloroflexi,375FD@32061|Chloroflexia	32061|Chloroflexia	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
TLS1_k127_5356554_5	765420.OSCT_1557	3.138e-79	277.0	COG1079@1|root,COG1079@2|Bacteria,2G6BT@200795|Chloroflexi,374T2@32061|Chloroflexia	32061|Chloroflexia	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
TLS1_k127_5356554_13	479434.Sthe_0084	1.735e-27	129.0	COG1832@1|root,COG1832@2|Bacteria	2|Bacteria	S	CoA binding domain	yccU	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.5.1.49	ko:K01740,ko:K06929	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	CoA_binding_2
TLS1_k127_5356554_4	373903.Hore_02340	1.336e-146	484.0	COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,247MS@186801|Clostridia,3WAGA@53433|Halanaerobiales	186801|Clostridia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
TLS1_k127_5356554_3	316274.Haur_4591	7.4e-149	481.0	COG0436@1|root,COG0436@2|Bacteria,2G5MC@200795|Chloroflexi,374TY@32061|Chloroflexia	32061|Chloroflexia	E	aminotransferase class I and II	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS1_k127_5356554_2	1382356.JQMP01000003_gene1786	1.574e-157	509.0	COG0154@1|root,COG0154@2|Bacteria,2G5T0@200795|Chloroflexi,27Y0A@189775|Thermomicrobia	189775|Thermomicrobia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TLS1_k127_5402426_4	1172188.KB911823_gene478	6.516e-51	188.0	COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,2GN0U@201174|Actinobacteria,4FESF@85021|Intrasporangiaceae	201174|Actinobacteria	HJM	Belongs to the MurCDEF family	cphA	-	6.3.2.29,6.3.2.30	ko:K03802	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Dala_Dala_lig_C,Mur_ligase_C,Mur_ligase_M,RimK
TLS1_k127_5402426_1	1032480.MLP_14770	1.649e-75	267.0	COG4242@1|root,COG4242@2|Bacteria,2I93U@201174|Actinobacteria,4DP1Z@85009|Propionibacteriales	201174|Actinobacteria	PQ	Peptidase family S51	cphB	-	3.4.15.6	ko:K13282	-	-	R09722	RC00064,RC00141	ko00000,ko01000,ko01002	-	-	-	Peptidase_S51
TLS1_k127_5402426_7	765420.OSCT_2937	6.356e-09	67.0	2EHBQ@1|root,33B3J@2|Bacteria	2|Bacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
TLS1_k127_5402426_5	552811.Dehly_1213	8.32e-46	187.0	COG2211@1|root,COG2211@2|Bacteria,2G8SN@200795|Chloroflexi	200795|Chloroflexi	G	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5402426_8	105425.BBPL01000015_gene2570	0.0008695	50.0	COG0121@1|root,COG0121@2|Bacteria,2IBFV@201174|Actinobacteria	201174|Actinobacteria	S	Glutamine amidotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	GATase_4,GATase_6
TLS1_k127_5402426_3	1254432.SCE1572_21240	1.414e-58	213.0	COG0266@1|root,COG0266@2|Bacteria,1N1J5@1224|Proteobacteria,433TA@68525|delta/epsilon subdivisions,2X3D6@28221|Deltaproteobacteria,2YVHV@29|Myxococcales	28221|Deltaproteobacteria	L	Belongs to the FPG family	-	-	4.2.99.18	ko:K05522	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS1_k127_5402426_0	1120936.KB907220_gene1989	0.0	1504.0	COG1201@1|root,COG1201@2|Bacteria,2GJG3@201174|Actinobacteria,4EI0Q@85012|Streptosporangiales	201174|Actinobacteria	L	DEAD/H associated	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,HTH_42,Helicase_C
TLS1_k127_5402426_2	479434.Sthe_2605	7.481e-63	224.0	COG2259@1|root,COG2259@2|Bacteria,2G6TC@200795|Chloroflexi,27Z4D@189775|Thermomicrobia	189775|Thermomicrobia	S	DoxX	-	-	1.8.5.2	ko:K16937	ko00920,ko01120,map00920,map01120	-	R07177	-	ko00000,ko00001,ko01000	3.D.4.9	-	-	DoxX
TLS1_k127_542632_0	926550.CLDAP_13750	9.275e-232	755.0	COG1404@1|root,COG1404@2|Bacteria,2G7GP@200795|Chloroflexi	200795|Chloroflexi	M	LPXTG-motif cell wall anchor domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4397
TLS1_k127_542632_1	96561.Dole_2374	1.321e-45	167.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,42KZJ@68525|delta/epsilon subdivisions,2WJ4U@28221|Deltaproteobacteria,2MJ7T@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
TLS1_k127_5456758_14	926569.ANT_18000	5.973e-11	70.0	COG2151@1|root,COG2151@2|Bacteria,2G9UF@200795|Chloroflexi	200795|Chloroflexi	S	Pfam:DUF59	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
TLS1_k127_5456758_13	1229780.BN381_80027	6.501e-36	149.0	COG2096@1|root,COG2096@2|Bacteria,2GMHN@201174|Actinobacteria,3UWVY@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Cobalamin adenosyltransferase	yvqK	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
TLS1_k127_5456758_11	406818.XBJ1_0975	5.242e-47	179.0	COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,1RN8Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the BI1 family	ybhL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06890	-	-	-	-	ko00000	-	-	-	Bax1-I
TLS1_k127_5456758_12	325452.fgenesh_scip_prom.46568.8852	6.195e-42	171.0	COG0546@1|root,2S0DN@2759|Eukaryota,3Q9ID@4776|Peronosporales	4776|Peronosporales	S	HAD-hyrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
TLS1_k127_5456758_5	383372.Rcas_1237	3.045e-146	473.0	COG3842@1|root,COG3842@2|Bacteria,2G5JJ@200795|Chloroflexi,37726@32061|Chloroflexia	32061|Chloroflexia	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
TLS1_k127_5456758_10	926569.ANT_31310	9.151e-81	285.0	COG1177@1|root,COG1177@2|Bacteria,2G80I@200795|Chloroflexi	200795|Chloroflexi	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02053	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
TLS1_k127_5456758_7	926569.ANT_31320	8.769e-111	366.0	COG4132@1|root,COG4132@2|Bacteria,2G69Y@200795|Chloroflexi	200795|Chloroflexi	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02054	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
TLS1_k127_5456758_4	639283.Snov_2169	2.255e-146	475.0	COG1840@1|root,COG1840@2|Bacteria,1Q13Q@1224|Proteobacteria,2TS7Y@28211|Alphaproteobacteria,3EZTQ@335928|Xanthobacteraceae	28211|Alphaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_6
TLS1_k127_5456758_6	1122611.KB903996_gene7455	6.411e-123	402.0	COG2113@1|root,COG2113@2|Bacteria,2GP39@201174|Actinobacteria,4ENIK@85012|Streptosporangiales	201174|Actinobacteria	E	Substrate binding domain of ABC-type glycine betaine transport system	-	-	-	ko:K02002	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
TLS1_k127_5456758_2	33876.JNXY01000009_gene8881	1.029e-199	644.0	COG4176@1|root,COG4176@2|Bacteria,2GKRF@201174|Actinobacteria,4DHGF@85008|Micromonosporales	201174|Actinobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02001	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
TLS1_k127_5456758_3	1157637.KB892105_gene1925	3.821e-151	491.0	COG4175@1|root,COG4175@2|Bacteria,2GJC0@201174|Actinobacteria	201174|Actinobacteria	E	glycine betaine	-	-	3.6.3.32	ko:K02000	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.12	-	-	ABC_tran,CBS
TLS1_k127_5456758_1	882082.SaccyDRAFT_4219	3.374e-211	666.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4E0HF@85010|Pseudonocardiales	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.8	ko:K00130	ko00260,ko01100,map00260,map01100	M00555	R02565,R02566	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS1_k127_5456758_0	321955.AAGP01000017_gene2194	0.0	1167.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,2GNCW@201174|Actinobacteria,4FAN4@85019|Brevibacteriaceae	201174|Actinobacteria	E	FAD dependent oxidoreductase central domain	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
TLS1_k127_5456758_9	797304.Natgr_2922	1.316e-81	280.0	COG2086@1|root,arCOG00446@2157|Archaea,2XW02@28890|Euryarchaeota,23TZ0@183963|Halobacteria	183963|Halobacteria	C	Electron transfer flavoprotein, beta subunit	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
TLS1_k127_5456758_8	634497.HAH_5184	5.754e-94	330.0	COG2025@1|root,arCOG00447@2157|Archaea,2XUIS@28890|Euryarchaeota,23T9A@183963|Halobacteria	183963|Halobacteria	C	Electron transfer flavoprotein	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
TLS1_k127_554445_8	243230.DR_1389	1.529e-33	138.0	COG1040@1|root,COG1040@2|Bacteria,1WKB1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM Phosphoribosyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
TLS1_k127_554445_9	574087.Acear_0275	1.139e-32	134.0	COG1544@1|root,COG1544@2|Bacteria,1V1D5@1239|Firmicutes,24HDH@186801|Clostridia,3WAMR@53433|Halanaerobiales	186801|Clostridia	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
TLS1_k127_554445_6	485913.Krac_8850	1.196e-56	211.0	COG0648@1|root,COG0648@2|Bacteria,2G5XZ@200795|Chloroflexi	200795|Chloroflexi	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
TLS1_k127_554445_11	1463857.JOFZ01000009_gene6275	3.055e-05	53.0	COG1396@1|root,COG1396@2|Bacteria,2IKVI@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
TLS1_k127_554445_5	765420.OSCT_0478	8.158e-66	243.0	COG0392@1|root,COG0392@2|Bacteria,2G6NX@200795|Chloroflexi,3765H@32061|Chloroflexia	32061|Chloroflexia	S	PFAM conserved	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
TLS1_k127_554445_10	1123288.SOV_5c00600	3.157e-32	136.0	COG0613@1|root,COG0613@2|Bacteria,1VCKE@1239|Firmicutes,4H57V@909932|Negativicutes	909932|Negativicutes	S	PHP-associated	-	-	-	-	-	-	-	-	-	-	-	-	PHP,PHP_C
TLS1_k127_554445_1	1382356.JQMP01000003_gene1994	1.726e-139	450.0	COG1077@1|root,COG1077@2|Bacteria,2G5KV@200795|Chloroflexi,27Y3P@189775|Thermomicrobia	189775|Thermomicrobia	D	Cell division protein FtsA	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
TLS1_k127_554445_2	670307.HYPDE_37233	3.839e-105	357.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2TRPH@28211|Alphaproteobacteria,3N66J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
TLS1_k127_554445_7	552811.Dehly_0552	5.219e-34	135.0	COG0355@1|root,COG0355@2|Bacteria,2G70H@200795|Chloroflexi,34DAK@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
TLS1_k127_554445_0	525904.Tter_0063	5.35e-219	695.0	COG0055@1|root,COG0055@2|Bacteria,2NNRB@2323|unclassified Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
TLS1_k127_554445_4	525904.Tter_0064	2.968e-80	276.0	COG0224@1|root,COG0224@2|Bacteria,2NP76@2323|unclassified Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iLJ478.TM1611,iSSON_1240.SSON_3886,iYL1228.KPN_04138	ATP-synt
TLS1_k127_5570367_11	479435.Kfla_5222	2.56e-14	74.0	COG0624@1|root,COG0624@2|Bacteria,2I8IJ@201174|Actinobacteria,4DPX4@85009|Propionibacteriales	201174|Actinobacteria	E	Acetylornithine deacetylase	-	-	3.5.1.16,3.5.1.18	ko:K01438,ko:K01439	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00669,R02734,R09107	RC00064,RC00090,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS1_k127_5570367_3	287986.DV20_18745	3.756e-68	253.0	COG0477@1|root,COG0477@2|Bacteria,2IIAH@201174|Actinobacteria,4EF98@85010|Pseudonocardiales	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
TLS1_k127_5570367_0	981384.AEYW01000018_gene3284	2.914e-293	939.0	COG1112@1|root,COG2251@1|root,COG1112@2|Bacteria,COG2251@2|Bacteria,1MWW9@1224|Proteobacteria,2TTSD@28211|Alphaproteobacteria,4NCZM@97050|Ruegeria	28211|Alphaproteobacteria	L	RNase_H superfamily	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12,AAA_30,RNase_H_2
TLS1_k127_5570367_12	383372.Rcas_2100	1.943e-11	71.0	2DRW3@1|root,33DCW@2|Bacteria,2G7E0@200795|Chloroflexi,37627@32061|Chloroflexia	32061|Chloroflexia	S	Domain of unknown function (DUF1992)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1992
TLS1_k127_5570367_9	477641.MODMU_2470	2.323e-20	97.0	COG1113@1|root,COG1113@2|Bacteria,2GRKY@201174|Actinobacteria,4EWX2@85013|Frankiales	201174|Actinobacteria	E	amino acid transport	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5570367_5	411902.CLOBOL_06599	1.209e-56	213.0	COG1470@1|root,COG1470@2|Bacteria,1TZ9A@1239|Firmicutes,24C4A@186801|Clostridia,221SZ@1506553|Lachnoclostridium	186801|Clostridia	S	NPCBM-associated, NEW3 domain of alpha-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	NPCBM_assoc
TLS1_k127_5570367_2	1209989.TepiRe1_2708	2.172e-80	284.0	COG1131@1|root,COG1131@2|Bacteria,1TQUS@1239|Firmicutes,25AZ1@186801|Clostridia,42ENV@68295|Thermoanaerobacterales	186801|Clostridia	V	PFAM ABC transporter related	-	-	-	ko:K01990,ko:K19340	ko02010,map02010	M00254,M00762	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.132.2	-	-	ABC_tran
TLS1_k127_5570367_4	743719.PaelaDRAFT_2160	1.256e-59	224.0	COG1277@1|root,COG1277@2|Bacteria,1TQM9@1239|Firmicutes,4HDI1@91061|Bacilli,26U85@186822|Paenibacillaceae	91061|Bacilli	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
TLS1_k127_5570367_8	446471.Xcel_2365	5.196e-24	116.0	COG2227@1|root,COG2227@2|Bacteria,2IIE2@201174|Actinobacteria	201174|Actinobacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.11	ko:K03428	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R04237	RC00003,RC00460	ko00000,ko00001,ko01000	-	-	-	Methyltransf_11,Methyltransf_25
TLS1_k127_5570367_7	1380356.JNIK01000014_gene3222	1.357e-24	107.0	2BZ6B@1|root,336KR@2|Bacteria,2IQEV@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5570367_10	479434.Sthe_2622	1.584e-18	100.0	COG2823@1|root,COG2823@2|Bacteria	2|Bacteria	S	hyperosmotic response	-	-	-	ko:K04065	-	-	-	-	ko00000	-	-	-	BON
TLS1_k127_5570367_1	479434.Sthe_0004	4.2e-125	411.0	COG2141@1|root,COG2141@2|Bacteria,2G5JS@200795|Chloroflexi,27XTW@189775|Thermomicrobia	200795|Chloroflexi	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS1_k127_5570367_13	479433.Caci_4856	1.418e-07	61.0	COG1158@1|root,COG1158@2|Bacteria,2IKUK@201174|Actinobacteria	201174|Actinobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5570367_6	351607.Acel_1171	3.873e-54	193.0	COG5032@1|root,COG5032@2|Bacteria,2GME7@201174|Actinobacteria,4ERWK@85013|Frankiales	201174|Actinobacteria	BDLTU	Phosphatidylinositol	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5573242_0	760568.Desku_1927	4.303e-147	479.0	COG1154@1|root,COG1154@2|Bacteria,1TP37@1239|Firmicutes,247P1@186801|Clostridia,2604R@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
TLS1_k127_5573242_8	231434.JQJH01000021_gene1634	1.131e-07	57.0	COG1722@1|root,COG1722@2|Bacteria,1PTYQ@1224|Proteobacteria,2UFD6@28211|Alphaproteobacteria,3NBFR@45404|Beijerinckiaceae	28211|Alphaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
TLS1_k127_5573242_1	1382356.JQMP01000003_gene2332	2.631e-85	300.0	COG1570@1|root,COG1570@2|Bacteria,2G5M3@200795|Chloroflexi,27XEW@189775|Thermomicrobia	189775|Thermomicrobia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
TLS1_k127_5573242_9	1121920.AUAU01000005_gene974	0.000828	50.0	COG2318@1|root,COG2318@2|Bacteria,3Y5VC@57723|Acidobacteria	57723|Acidobacteria	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS1_k127_5573242_3	309801.trd_1698	8.879e-62	220.0	COG0231@1|root,COG0231@2|Bacteria,2G6PY@200795|Chloroflexi,27Y78@189775|Thermomicrobia	189775|Thermomicrobia	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
TLS1_k127_5573242_2	867903.ThesuDRAFT_00059	1.723e-62	234.0	COG0006@1|root,COG0006@2|Bacteria,1TQ44@1239|Firmicutes,247SG@186801|Clostridia,3WD7A@538999|Clostridiales incertae sedis	186801|Clostridia	E	Creatinase/Prolidase N-terminal domain	pepP	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
TLS1_k127_5573242_4	479434.Sthe_3265	1.172e-46	189.0	COG1559@1|root,COG1559@2|Bacteria,2G6G8@200795|Chloroflexi,27XHU@189775|Thermomicrobia	189775|Thermomicrobia	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
TLS1_k127_5573242_6	326427.Cagg_0094	3.932e-15	89.0	COG0816@1|root,COG0816@2|Bacteria,2G74F@200795|Chloroflexi,375V0@32061|Chloroflexia	32061|Chloroflexia	J	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
TLS1_k127_5573242_7	926550.CLDAP_11390	5.904e-13	82.0	COG3299@1|root,COG3299@2|Bacteria	2|Bacteria	S	Baseplate J-like protein	-	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	Baseplate_J,PA14,fn3
TLS1_k127_5573242_5	1382306.JNIM01000001_gene244	2.263e-23	103.0	COG0849@1|root,COG0849@2|Bacteria	2|Bacteria	D	cell division	-	-	-	-	-	-	-	-	-	-	-	-	FtsA
TLS1_k127_5627960_4	1128421.JAGA01000002_gene685	3.533e-44	176.0	COG3854@1|root,COG3854@2|Bacteria,2NQEN@2323|unclassified Bacteria	2|Bacteria	S	R3H domain	ycf45	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_30,R3H
TLS1_k127_5627960_3	1128421.JAGA01000002_gene1198	4.471e-58	206.0	COG5485@1|root,COG5485@2|Bacteria	2|Bacteria	S	SnoaL-like polyketide cyclase	-	-	-	ko:K15945	ko01057,ko01130,map01057,map01130	-	R09330	RC00046	ko00000,ko00001	-	-	-	SnoaL,SnoaL_2
TLS1_k127_5627960_5	1380393.JHVP01000018_gene144	9.484e-27	114.0	COG3871@1|root,COG3871@2|Bacteria,2IM6Z@201174|Actinobacteria	201174|Actinobacteria	S	pyridoxamine 5-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Pyrid_ox_like
TLS1_k127_5627960_2	511051.CSE_14850	3.306e-76	276.0	COG0312@1|root,COG0312@2|Bacteria	2|Bacteria	S	metallopeptidase activity	tldE2	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
TLS1_k127_5627960_0	515635.Dtur_0186	4.173e-153	498.0	COG0312@1|root,COG0312@2|Bacteria	2|Bacteria	S	metallopeptidase activity	tldD2	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
TLS1_k127_5627960_1	330214.NIDE3314	1.39e-151	505.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
TLS1_k127_563962_8	1380347.JNII01000005_gene3003	4.746e-49	186.0	COG5032@1|root,COG5032@2|Bacteria,2GME7@201174|Actinobacteria,4ERWK@85013|Frankiales	201174|Actinobacteria	BDLTU	Phosphatidylinositol	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_563962_10	134676.ACPL_5268	1.515e-45	186.0	298YA@1|root,2ZW25@2|Bacteria,2GIYI@201174|Actinobacteria,4D9TX@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3090)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3090
TLS1_k127_563962_0	1146883.BLASA_1733	6.017e-134	445.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria,4ERKK@85013|Frankiales	201174|Actinobacteria	S	PFAM oxidoreductase molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
TLS1_k127_563962_5	1229780.BN381_50167	1.355e-70	252.0	COG1119@1|root,COG1119@2|Bacteria,2GIXX@201174|Actinobacteria,3UWHV@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
TLS1_k127_563962_7	1038862.KB893807_gene2069	1.517e-61	224.0	COG1984@1|root,COG1984@2|Bacteria,1MU9H@1224|Proteobacteria,2TS7P@28211|Alphaproteobacteria,3JW9R@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Allophanate hydrolase subunit 2	-	-	-	-	-	-	-	-	-	-	-	-	CT_A_B
TLS1_k127_563962_9	243233.MCA0478	8.616e-49	190.0	COG2049@1|root,COG2049@2|Bacteria,1MWRB@1224|Proteobacteria,1RQIQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Allophanate hydrolase, subunit 1	ybgJ	-	-	-	-	-	-	-	-	-	-	-	CT_C_D
TLS1_k127_563962_4	765420.OSCT_0765	4.64e-77	269.0	COG1540@1|root,COG1540@2|Bacteria,2G8DT@200795|Chloroflexi,377AU@32061|Chloroflexia	32061|Chloroflexia	S	Belongs to the UPF0271 (lamB) family	-	-	-	ko:K07160	-	-	-	-	ko00000	-	-	-	LamB_YcsF
TLS1_k127_563962_3	1128421.JAGA01000002_gene1247	6.197e-81	302.0	COG0744@1|root,COG0744@2|Bacteria	2|Bacteria	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mrcB	-	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
TLS1_k127_563962_1	285535.JOEY01000056_gene6770	1.288e-130	425.0	COG1486@1|root,COG1486@2|Bacteria,2GK80@201174|Actinobacteria	201174|Actinobacteria	G	family 4	-	-	3.2.1.86	ko:K01222	ko00010,ko00500,map00010,map00500	-	R00839,R05133,R05134	RC00049,RC00171,RC00714	ko00000,ko00001,ko01000	-	GT4	-	Glyco_hydro_4,Glyco_hydro_4C
TLS1_k127_563962_11	1968.JOEV01000005_gene6126	8.151e-21	95.0	COG1486@1|root,COG1486@2|Bacteria,2GK80@201174|Actinobacteria	201174|Actinobacteria	G	family 4	-	-	3.2.1.86	ko:K01222	ko00010,ko00500,map00010,map00500	-	R00839,R05133,R05134	RC00049,RC00171,RC00714	ko00000,ko00001,ko01000	-	GT4	-	Glyco_hydro_4,Glyco_hydro_4C
TLS1_k127_563962_6	1227261.HMPREF0043_00480	7.644e-62	222.0	COG2188@1|root,COG2188@2|Bacteria,2GJZ1@201174|Actinobacteria,4D51Y@85005|Actinomycetales	201174|Actinobacteria	K	UbiC transcription regulator-associated domain protein	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
TLS1_k127_563962_2	1463821.JOGR01000010_gene3655	4.077e-116	395.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
TLS1_k127_5697779_0	525904.Tter_1226	4.422e-114	382.0	COG0492@1|root,COG0492@2|Bacteria,2NNS7@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.9	ko:K00384,ko:K03671	ko00450,ko04621,ko05418,map00450,map04621,map05418	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110	-	-	iNJ661.Rv3913	Pyr_redox_2
TLS1_k127_5697779_5	365046.Rta_15000	1.39e-35	145.0	COG0668@1|root,COG0668@2|Bacteria,1N2GE@1224|Proteobacteria,2WFQP@28216|Betaproteobacteria,4ABHJ@80864|Comamonadaceae	28216|Betaproteobacteria	M	PFAM Conserved TM helix repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TM_helix
TLS1_k127_5697779_2	1394178.AWOO02000048_gene6370	6.767e-98	328.0	COG2141@1|root,COG2141@2|Bacteria,2GM7W@201174|Actinobacteria,4EIGV@85012|Streptosporangiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS1_k127_5697779_3	1236902.ANAS01000005_gene4955	5.72e-46	184.0	COG0515@1|root,COG0515@2|Bacteria,2GMPZ@201174|Actinobacteria,4EHZK@85012|Streptosporangiales	201174|Actinobacteria	KLT	Protein tyrosine kinase	pknA	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
TLS1_k127_5697779_1	471852.Tcur_2452	1.24e-104	361.0	COG3214@1|root,COG3214@2|Bacteria,2GK0T@201174|Actinobacteria,4EI5K@85012|Streptosporangiales	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
TLS1_k127_5697779_4	492774.JQMB01000011_gene4521	2.928e-42	160.0	COG1846@1|root,COG1846@2|Bacteria,1MZXE@1224|Proteobacteria,2UK9X@28211|Alphaproteobacteria,4BFYK@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
TLS1_k127_5697779_10	110319.CF8_1931	1.925e-13	79.0	2DF72@1|root,32U4U@2|Bacteria,2GIV4@201174|Actinobacteria,4DR5D@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5697779_8	1122138.AQUZ01000066_gene4381	1.979e-18	91.0	COG2350@1|root,COG2350@2|Bacteria,2GV9T@201174|Actinobacteria	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
TLS1_k127_5697779_7	1435356.Y013_03320	1.161e-18	93.0	COG1595@1|root,COG1595@2|Bacteria,2GJMX@201174|Actinobacteria,4FVYM@85025|Nocardiaceae	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS1_k127_5697779_9	1219045.BV98_003047	8.176e-14	85.0	COG3391@1|root,COG3391@2|Bacteria,1R53R@1224|Proteobacteria,2U1FC@28211|Alphaproteobacteria,2K0VC@204457|Sphingomonadales	204457|Sphingomonadales	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5697779_6	1380370.JIBA01000003_gene2738	1.653e-19	89.0	2DQWK@1|root,3393J@2|Bacteria,2IEMK@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5717728_2	1313172.YM304_41080	4.839e-15	80.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
TLS1_k127_5717728_0	570268.ANBB01000054_gene4616	1.65e-109	365.0	COG1609@1|root,COG1609@2|Bacteria,2GJV7@201174|Actinobacteria,4EHJN@85012|Streptosporangiales	201174|Actinobacteria	K	helix_turn _helix lactose operon repressor	cebR	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
TLS1_k127_5717728_1	1128421.JAGA01000003_gene3394	1.5e-15	85.0	COG5297@1|root,COG5297@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase family 6	celA	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM_2,Glyco_hydro_6
TLS1_k127_5719355_1	1380390.JIAT01000009_gene1628	2.881e-103	374.0	COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS1_k127_5719355_6	521011.Mpal_0675	0.0005037	51.0	COG2133@1|root,arCOG03441@1|root,arCOG02796@2157|Archaea,arCOG03441@2157|Archaea,2XT1Q@28890|Euryarchaeota	28890|Euryarchaeota	G	COG2133 Glucose sorbosone dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1,GSDH
TLS1_k127_5719355_2	536227.CcarbDRAFT_4777	1.941e-75	261.0	COG2872@1|root,COG2872@2|Bacteria,1UHS6@1239|Firmicutes,24AK0@186801|Clostridia,36GRN@31979|Clostridiaceae	186801|Clostridia	S	Threonyl alanyl tRNA synthetase SAD	-	-	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
TLS1_k127_5719355_3	1385520.N802_12190	8.221e-41	157.0	COG2606@1|root,COG2606@2|Bacteria,2IIIW@201174|Actinobacteria,4FGY4@85021|Intrasporangiaceae	201174|Actinobacteria	S	Aminoacyl-tRNA editing domain	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
TLS1_k127_5719355_4	373903.Hore_07790	2.15e-35	143.0	COG1285@1|root,COG1285@2|Bacteria,1V409@1239|Firmicutes,249SQ@186801|Clostridia,3WAS3@53433|Halanaerobiales	186801|Clostridia	S	PFAM MgtC SapB transporter	-	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	ACT,ACT_4,MgtC
TLS1_k127_5719355_0	1298863.AUEP01000007_gene351	6.34e-135	440.0	COG1226@1|root,COG1226@2|Bacteria,2HZRR@201174|Actinobacteria,4DTS4@85009|Propionibacteriales	201174|Actinobacteria	P	TrkA-N domain	-	-	-	-	-	-	-	-	-	-	-	-	TrkA_N
TLS1_k127_5719355_5	1449976.KALB_6351	1.069e-13	71.0	COG1282@1|root,COG1282@2|Bacteria,2GNKB@201174|Actinobacteria,4DX5F@85010|Pseudonocardiales	201174|Actinobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
TLS1_k127_5738553_8	2074.JNYD01000007_gene2100	1.216e-57	216.0	COG5438@1|root,COG5438@2|Bacteria,2GKJ4@201174|Actinobacteria,4DY5S@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM YibE F-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YibE_F
TLS1_k127_5738553_15	1206732.BAGD01000280_gene6547	2.275e-27	119.0	COG1510@1|root,COG1510@2|Bacteria,2GSV5@201174|Actinobacteria,4G974@85025|Nocardiaceae	201174|Actinobacteria	K	regulation of RNA biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
TLS1_k127_5738553_3	33876.JNXY01000029_gene2662	2.219e-122	408.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,4D8QU@85008|Micromonosporales	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS1_k127_5738553_5	33876.JNXY01000029_gene2661	1.039e-115	393.0	COG3559@1|root,COG3559@2|Bacteria	2|Bacteria	M	Exporter of polyketide antibiotics	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
TLS1_k127_5738553_13	246200.SPOA0210	1.542e-33	141.0	COG0697@1|root,COG0697@2|Bacteria,1R46X@1224|Proteobacteria,2TSE9@28211|Alphaproteobacteria,4NB15@97050|Ruegeria	28211|Alphaproteobacteria	EG	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	EamA,Multi_Drug_Res
TLS1_k127_5738553_9	926569.ANT_28890	9.49e-57	209.0	COG0697@1|root,COG0697@2|Bacteria,2G6ZR@200795|Chloroflexi	200795|Chloroflexi	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS1_k127_5738553_2	649638.Trad_1756	4.86e-137	457.0	COG0165@1|root,COG0165@2|Bacteria,1WI7D@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	argininosuccinate lyase	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
TLS1_k127_5738553_12	1120949.KB903303_gene6830	1.143e-37	144.0	2EAYY@1|root,334ZV@2|Bacteria,2I2ZT@201174|Actinobacteria,4DMTF@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
TLS1_k127_5738553_14	1385520.N802_13445	1.114e-31	136.0	2E3HM@1|root,32YG7@2|Bacteria,2HXYZ@201174|Actinobacteria,4FIPY@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5738553_0	44060.JODL01000002_gene2286	1.201e-163	523.0	COG1816@1|root,COG1816@2|Bacteria,2GJ6I@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism	add	GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3313c	A_deaminase
TLS1_k127_5738553_4	1150399.AQYK01000001_gene1784	1.124e-120	402.0	COG0477@1|root,COG2814@2|Bacteria,2GKHG@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
TLS1_k127_5738553_7	1416759.AYMR01000009_gene3323	7.062e-93	331.0	COG0477@1|root,COG2814@2|Bacteria,2GKHG@201174|Actinobacteria,4FS5J@85023|Microbacteriaceae	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
TLS1_k127_5738553_19	136993.KB900626_gene4050	0.0004827	43.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,36Y0R@31993|Methylocystaceae	28211|Alphaproteobacteria	T	PAS fold	fixL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K14986	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA,PAS,PAS_3,PAS_9
TLS1_k127_5738553_16	1380386.JIAW01000006_gene1203	2.902e-25	122.0	COG0642@1|root,COG2205@2|Bacteria,2I2M2@201174|Actinobacteria,23FDA@1762|Mycobacteriaceae	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,GAF_2,HAMP,HATPase_c,HisKA,Response_reg
TLS1_k127_5738553_11	37919.EP51_00200	3.259e-43	165.0	COG1309@1|root,COG1309@2|Bacteria,2IFH9@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS1_k127_5738553_6	675635.Psed_0701	7.417e-114	386.0	COG0654@1|root,COG0654@2|Bacteria,2GKUZ@201174|Actinobacteria,4DX8V@85010|Pseudonocardiales	201174|Actinobacteria	CH	FAD binding domain	sppF	-	1.14.13.200	ko:K14672,ko:K15972	ko01057,ko01130,map01057,map01130	M00783	R06704,R10954	RC02681	ko00000,ko00001,ko00002,ko01000,ko01008	-	-	-	FAD_binding_3
TLS1_k127_5738553_1	867903.ThesuDRAFT_02026	1.673e-146	484.0	COG0137@1|root,COG0137@2|Bacteria,1TP3X@1239|Firmicutes,247MF@186801|Clostridia,3WCR7@538999|Clostridiales incertae sedis	186801|Clostridia	H	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
TLS1_k127_5738553_18	1131462.DCF50_p525	7.02e-22	109.0	COG1438@1|root,COG1438@2|Bacteria,1V1R7@1239|Firmicutes,24HGQ@186801|Clostridia,2625T@186807|Peptococcaceae	186801|Clostridia	K	Regulates arginine biosynthesis genes	argR	-	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
TLS1_k127_5738553_10	1297617.JPJD01000086_gene626	7.772e-44	171.0	COG0548@1|root,COG0769@1|root,COG0548@2|Bacteria,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,248Q4@186801|Clostridia,267YB@186813|unclassified Clostridiales	186801|Clostridia	M	Mur ligase family, glutamate ligase domain	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS1_k127_5738553_17	1123389.ATXJ01000002_gene1490	3.659e-24	107.0	COG1364@1|root,COG1364@2|Bacteria,1WJ29@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
TLS1_k127_5834519_2	926569.ANT_27600	1.856e-50	183.0	COG0578@1|root,COG0578@2|Bacteria,2G63S@200795|Chloroflexi	200795|Chloroflexi	C	PFAM FAD dependent oxidoreductase	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,Fer2_BFD
TLS1_k127_5834519_3	926569.ANT_27590	5.156e-48	184.0	COG0479@1|root,COG0479@2|Bacteria,2G659@200795|Chloroflexi	200795|Chloroflexi	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
TLS1_k127_5834519_5	644282.Deba_1091	8.66e-11	70.0	COG2009@1|root,COG2009@2|Bacteria,1MZMK@1224|Proteobacteria,433FS@68525|delta/epsilon subdivisions,2WX63@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	-	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
TLS1_k127_5834519_4	446470.Snas_3206	2.157e-35	139.0	2DRYE@1|root,33DPC@2|Bacteria,2IS24@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5834519_1	997346.HMPREF9374_2912	8.637e-75	258.0	COG2320@1|root,COG2320@2|Bacteria,1V3IB@1239|Firmicutes,4HH5X@91061|Bacilli,27CBM@186824|Thermoactinomycetaceae	91061|Bacilli	S	GrpB protein	-	-	-	-	-	-	-	-	-	-	-	-	GrpB
TLS1_k127_5834519_0	643648.Slip_1742	6.191e-116	383.0	COG2876@1|root,COG2876@2|Bacteria,1TP61@1239|Firmicutes,24812@186801|Clostridia,42JHR@68298|Syntrophomonadaceae	186801|Clostridia	H	NeuB family	aroF1	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
TLS1_k127_5835970_4	324602.Caur_2890	3.087e-63	244.0	COG0111@1|root,COG0111@2|Bacteria,2G6KY@200795|Chloroflexi,376P6@32061|Chloroflexia	32061|Chloroflexia	C	PFAM D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS1_k127_5835970_3	479434.Sthe_1576	5.231e-71	260.0	COG5282@1|root,COG5282@2|Bacteria,2G800@200795|Chloroflexi,27XTJ@189775|Thermomicrobia	189775|Thermomicrobia	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_2
TLS1_k127_5835970_5	266117.Rxyl_1602	2.636e-61	223.0	COG0796@1|root,COG0796@2|Bacteria,2GN4I@201174|Actinobacteria,4CQ0N@84995|Rubrobacteria	84995|Rubrobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
TLS1_k127_5835970_6	1521187.JPIM01000017_gene329	3.917e-39	162.0	COG4753@1|root,COG4963@1|root,COG4753@2|Bacteria,COG4963@2|Bacteria,2G6CH@200795|Chloroflexi,37524@32061|Chloroflexia	32061|Chloroflexia	D	PFAM response regulator receiver	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,ParA,Response_reg
TLS1_k127_5835970_7	1382356.JQMP01000003_gene2347	6.119e-33	138.0	COG0500@1|root,COG2226@2|Bacteria,2G6N8@200795|Chloroflexi,27Y5W@189775|Thermomicrobia	189775|Thermomicrobia	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS1_k127_5835970_0	298655.KI912266_gene6560	1.393e-118	393.0	COG0010@1|root,COG0010@2|Bacteria,2GJA6@201174|Actinobacteria,4EUWY@85013|Frankiales	201174|Actinobacteria	E	Belongs to the arginase family	speB	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
TLS1_k127_5835970_2	1382304.JNIL01000001_gene1097	1.357e-80	283.0	COG1473@1|root,COG1473@2|Bacteria,1TQ7B@1239|Firmicutes,4HAIK@91061|Bacilli	91061|Bacilli	F	amidohydrolase	-	-	-	ko:K21613	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
TLS1_k127_5835970_8	1286631.X805_39930	1.545e-09	70.0	COG1011@1|root,COG1011@2|Bacteria,1N0I6@1224|Proteobacteria,2VR50@28216|Betaproteobacteria,1KKTK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	HAD-hyrolase-like	-	-	3.1.3.102,3.1.3.104	ko:K20862	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00548,R07280	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD_2,Hydrolase
TLS1_k127_5835970_1	671143.DAMO_2896	7.195e-98	337.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2NNZG@2323|unclassified Bacteria	2|Bacteria	L	UvrD/REP helicase N-terminal domain	-	-	3.6.4.12	ko:K03657,ko:K07465	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
TLS1_k127_5841961_7	314230.DSM3645_18411	7.222e-21	103.0	COG1449@1|root,COG1449@2|Bacteria,2IY67@203682|Planctomycetes	203682|Planctomycetes	G	Belongs to the glycosyl hydrolase 57 family	-	-	2.4.1.25	ko:K22451	ko00500,map00500	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH57	-	DUF1925,DUF1926,Glyco_hydro_57
TLS1_k127_5841961_3	926569.ANT_17340	4.726e-103	357.0	COG1449@1|root,COG1449@2|Bacteria,2G5XB@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3536,Glyco_hydro_57
TLS1_k127_5841961_4	1121403.AUCV01000032_gene2901	1.348e-90	310.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,42MEE@68525|delta/epsilon subdivisions,2WJYV@28221|Deltaproteobacteria,2MJ0G@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
TLS1_k127_5841961_9	28444.JODQ01000004_gene6167	2.914e-05	55.0	COG1167@1|root,COG1167@2|Bacteria,2IG0J@201174|Actinobacteria,4ENFA@85012|Streptosporangiales	201174|Actinobacteria	EK	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2,GntR
TLS1_k127_5841961_0	1128421.JAGA01000003_gene2953	3.106e-306	971.0	COG0366@1|root,COG0366@2|Bacteria,2NQQN@2323|unclassified Bacteria	2|Bacteria	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
TLS1_k127_5841961_2	1442599.JAAN01000030_gene2079	1.623e-106	367.0	COG4805@1|root,COG4805@2|Bacteria,1R5EP@1224|Proteobacteria,1RRS6@1236|Gammaproteobacteria,1X3WH@135614|Xanthomonadales	135614|Xanthomonadales	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
TLS1_k127_5841961_6	1207063.P24_18586	1.701e-59	211.0	COG1670@1|root,COG1670@2|Bacteria,1MXEE@1224|Proteobacteria,2U62V@28211|Alphaproteobacteria,2JRXQ@204441|Rhodospirillales	204441|Rhodospirillales	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS1_k127_5841961_8	47763.JNZA01000009_gene5492	8.536e-18	91.0	COG1950@1|root,COG1950@2|Bacteria,2IHP5@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
TLS1_k127_5841961_1	1445613.JALM01000009_gene898	7.245e-111	372.0	COG0019@1|root,COG0019@2|Bacteria,2GKAI@201174|Actinobacteria,4DYM2@85010|Pseudonocardiales	201174|Actinobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
TLS1_k127_5841961_5	926550.CLDAP_35370	3.745e-71	250.0	COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,2G674@200795|Chloroflexi	200795|Chloroflexi	H	Homocysteine S-methyltransferase	-	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,S-methyl_trans
TLS1_k127_5937252_0	479434.Sthe_1702	7.487e-113	376.0	COG1197@1|root,COG1197@2|Bacteria,2G5UW@200795|Chloroflexi,27XUQ@189775|Thermomicrobia	189775|Thermomicrobia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
TLS1_k127_5937252_3	216594.MMAR_0333	5.399e-13	74.0	COG0664@1|root,COG0664@2|Bacteria,2I8MP@201174|Actinobacteria,2375B@1762|Mycobacteriaceae	201174|Actinobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,cNMP_binding
TLS1_k127_5937252_2	1136417.AZWE01000042_gene161	3.989e-14	79.0	2ER8X@1|root,33IUI@2|Bacteria,2IRAS@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
TLS1_k127_5937252_1	1463920.JOGB01000036_gene6792	1.215e-34	142.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2,CelD_N,Glyco_hydro_9,Laminin_G_3
TLS1_k127_5974918_9	621372.ACIH01000143_gene211	4.831e-95	343.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,4HAM7@91061|Bacilli,26TIQ@186822|Paenibacillaceae	91061|Bacilli	E	ABC transporter substrate-binding protein	dppA	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS1_k127_5974918_8	867903.ThesuDRAFT_02281	1.677e-113	394.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,3WCUJ@538999|Clostridiales incertae sedis	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
TLS1_k127_5974918_7	1051632.TPY_0984	1.674e-116	400.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
TLS1_k127_5974918_12	404380.Gbem_2642	2.024e-69	247.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,42MFP@68525|delta/epsilon subdivisions,2WJ47@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TLS1_k127_5974918_11	1382356.JQMP01000003_gene2440	6.35e-76	267.0	COG0601@1|root,COG0601@2|Bacteria,2GA2P@200795|Chloroflexi,27YUQ@189775|Thermomicrobia	189775|Thermomicrobia	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS1_k127_5974918_15	401526.TcarDRAFT_1875	8.134e-54	212.0	COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,4H2KV@909932|Negativicutes	909932|Negativicutes	E	ABC transporter substrate-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS1_k127_5974918_19	1128421.JAGA01000002_gene1099	1.778e-35	143.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	M1-584	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS1_k127_5974918_2	867903.ThesuDRAFT_00057	1.053e-188	602.0	COG1003@1|root,COG1003@2|Bacteria,1TPK9@1239|Firmicutes,2480Q@186801|Clostridia,3WCD1@538999|Clostridiales incertae sedis	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,GDC-P
TLS1_k127_5974918_6	264732.Moth_1943	2.177e-118	396.0	COG0403@1|root,COG0403@2|Bacteria,1TQGG@1239|Firmicutes,2492A@186801|Clostridia,42EUH@68295|Thermoanaerobacterales	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
TLS1_k127_5974918_16	1168034.FH5T_07050	2.102e-46	170.0	COG0509@1|root,COG0509@2|Bacteria,4NQ35@976|Bacteroidetes,2FT3J@200643|Bacteroidia	976|Bacteroidetes	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
TLS1_k127_5974918_4	590998.Celf_3727	6.068e-121	405.0	COG0404@1|root,COG0404@2|Bacteria,2GJ47@201174|Actinobacteria,4F0J6@85016|Cellulomonadaceae	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
TLS1_k127_5974918_20	468556.AQYG01000045_gene1941	1.735e-27	122.0	COG0494@1|root,COG0494@2|Bacteria,2GWEB@201174|Actinobacteria,4GAV8@85026|Gordoniaceae	201174|Actinobacteria	L	NUDIX domain	mutT4	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS1_k127_5974918_18	479434.Sthe_0697	6.988e-38	157.0	COG5495@1|root,COG5495@2|Bacteria,2G6F3@200795|Chloroflexi,27YA4@189775|Thermomicrobia	189775|Thermomicrobia	S	Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2520,Rossmann-like
TLS1_k127_5974918_0	1382356.JQMP01000001_gene1192	0.0	1154.0	COG1048@1|root,COG1048@2|Bacteria,2G5NG@200795|Chloroflexi,27XND@189775|Thermomicrobia	189775|Thermomicrobia	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
TLS1_k127_5974918_10	1122221.JHVI01000017_gene2011	2.487e-90	315.0	COG0714@1|root,COG0714@2|Bacteria,1WJ11@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TLS1_k127_5974918_17	479434.Sthe_3135	2.487e-38	165.0	COG1721@1|root,COG1721@2|Bacteria,2G6Y7@200795|Chloroflexi,27Y3Z@189775|Thermomicrobia	189775|Thermomicrobia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
TLS1_k127_5974918_1	1304865.JAGF01000001_gene1313	0.0	1052.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria	201174|Actinobacteria	P	ATPase P-type (Transporting), HAD superfamily, subfamily IC	-	-	-	-	-	-	-	-	-	-	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
TLS1_k127_5974918_22	211114.JOEF01000016_gene3608	1.018e-08	59.0	COG1872@1|root,COG1872@2|Bacteria,2GQSC@201174|Actinobacteria,4E6KR@85010|Pseudonocardiales	201174|Actinobacteria	EGP	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
TLS1_k127_5974918_21	309801.trd_1854	9.832e-14	73.0	COG0762@1|root,COG0762@2|Bacteria,2G9QH@200795|Chloroflexi,27YQI@189775|Thermomicrobia	189775|Thermomicrobia	S	YGGT family	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
TLS1_k127_5974918_14	335543.Sfum_3628	9.328e-55	203.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,42PSG@68525|delta/epsilon subdivisions,2WKYN@28221|Deltaproteobacteria,2MRIU@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	yggS	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
TLS1_k127_5974918_3	370438.PTH_1850	1.139e-127	421.0	COG0206@1|root,COG0206@2|Bacteria,1TP6W@1239|Firmicutes,247Z5@186801|Clostridia,260UE@186807|Peptococcaceae	186801|Clostridia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
TLS1_k127_5974918_13	106370.Francci3_3056	1.042e-55	197.0	COG0432@1|root,COG0432@2|Bacteria,2IHWS@201174|Actinobacteria,4EVAT@85013|Frankiales	201174|Actinobacteria	S	Uncharacterised protein family UPF0047	-	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	UPF0047
TLS1_k127_5974918_5	1382306.JNIM01000001_gene41	1.445e-119	396.0	COG0849@1|root,COG0849@2|Bacteria,2G5V5@200795|Chloroflexi	200795|Chloroflexi	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
TLS1_k127_5980753_11	1382356.JQMP01000003_gene2146	2.148e-96	324.0	COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,2G674@200795|Chloroflexi,27Z2G@189775|Thermomicrobia	189775|Thermomicrobia	E	Homocysteine S-methyltransferase	-	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,S-methyl_trans
TLS1_k127_5980753_33	375286.mma_0603	3.913e-08	66.0	COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,2VMNV@28216|Betaproteobacteria,4733U@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
TLS1_k127_5980753_20	1415166.NONO_c43360	7.837e-62	220.0	COG0262@1|root,COG0262@2|Bacteria,2GKX0@201174|Actinobacteria,4FXXH@85025|Nocardiaceae	201174|Actinobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS1_k127_5980753_34	1121428.DESHY_40134___1	4.179e-08	66.0	COG1388@1|root,COG1388@2|Bacteria,1TSVC@1239|Firmicutes,248VQ@186801|Clostridia,26432@186807|Peptococcaceae	186801|Clostridia	M	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	DUF3794,LysM
TLS1_k127_5980753_23	1382358.JHVN01000014_gene1589	1.896e-49	189.0	COG0330@1|root,COG0330@2|Bacteria,1TR6S@1239|Firmicutes,4HKDW@91061|Bacilli	91061|Bacilli	O	Membrane protease subunits, stomatin prohibitin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
TLS1_k127_5980753_26	1122611.KB903963_gene4852	1.674e-41	163.0	293MU@1|root,2ZR3M@2|Bacteria,2IFCB@201174|Actinobacteria,4EJ6F@85012|Streptosporangiales	201174|Actinobacteria	S	Nickel-containing superoxide dismutase	sodN	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.15.1.1	ko:K00518	-	-	-	-	ko00000,ko01000	-	-	-	Sod_Ni
TLS1_k127_5980753_32	1125971.ASJB01000083_gene2018	1.306e-08	63.0	COG0681@1|root,COG0681@2|Bacteria,2GQUN@201174|Actinobacteria,4ED5N@85010|Pseudonocardiales	201174|Actinobacteria	U	Peptidase S24-like	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
TLS1_k127_5980753_37	1231190.NA8A_14319	3.029e-05	56.0	COG2222@1|root,COG2222@2|Bacteria,1MXC7@1224|Proteobacteria,2TUJY@28211|Alphaproteobacteria,43H3H@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	SIS domain	glmS2	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	SIS
TLS1_k127_5980753_14	103733.JNYO01000002_gene422	2.284e-75	265.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4DXNN@85010|Pseudonocardiales	201174|Actinobacteria	C	PFAM Luciferase-like monooxygenase	-	-	1.14.14.5	ko:K04091	ko00920,map00920	-	R07210,R10206	RC01779,RC02556	ko00000,ko00001,ko01000	-	-	-	Bac_luciferase
TLS1_k127_5980753_30	1305735.JAFT01000005_gene2422	1.467e-10	68.0	COG1846@1|root,COG1846@2|Bacteria,1MZE9@1224|Proteobacteria,2TSUB@28211|Alphaproteobacteria,2PE03@252301|Oceanicola	28211|Alphaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS1_k127_5980753_5	309801.trd_1170	4.248e-118	407.0	COG0477@1|root,COG2814@2|Bacteria,2GA6K@200795|Chloroflexi,27XGR@189775|Thermomicrobia	189775|Thermomicrobia	P	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
TLS1_k127_5980753_31	1382304.JNIL01000001_gene3222	1.589e-09	72.0	COG2146@1|root,COG2146@2|Bacteria,1VF0R@1239|Firmicutes,4HSGD@91061|Bacilli,27AES@186823|Alicyclobacillaceae	91061|Bacilli	P	Rieske-like [2Fe-2S] domain	-	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
TLS1_k127_5980753_13	1029824.AFID01000002_gene1530	1.015e-86	297.0	COG1611@1|root,COG1611@2|Bacteria,2GKJH@201174|Actinobacteria,1W86V@1268|Micrococcaceae	201174|Actinobacteria	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
TLS1_k127_5980753_35	1040989.AWZU01000019_gene1900	8.603e-07	53.0	2C7HC@1|root,2ZEX5@2|Bacteria,1N7NS@1224|Proteobacteria,2UGBA@28211|Alphaproteobacteria,3K173@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5980753_28	1267535.KB906767_gene4017	1.227e-34	137.0	COG1393@1|root,COG1393@2|Bacteria,3Y7VT@57723|Acidobacteria	57723|Acidobacteria	P	ArsC family	-	-	-	-	-	-	-	-	-	-	-	-	ArsC
TLS1_k127_5980753_22	456442.Mboo_1974	6.561e-54	199.0	COG1707@1|root,arCOG00813@2157|Archaea,2XT8A@28890|Euryarchaeota,2NAE8@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM amino acid-binding ACT domain protein	-	-	-	ko:K06862	-	-	-	-	ko00000	-	-	-	ACT
TLS1_k127_5980753_16	1313172.YM304_23330	1.322e-71	257.0	COG0708@1|root,COG0708@2|Bacteria,2GKEW@201174|Actinobacteria,4CN0I@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Endonuclease/Exonuclease/phosphatase family	xthA	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
TLS1_k127_5980753_4	266117.Rxyl_2912	5.202e-119	393.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4CRCY@84995|Rubrobacteria	84995|Rubrobacteria	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	3.6.3.31	ko:K11072	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1	-	-	ABC_tran,TOBE_2
TLS1_k127_5980753_21	266117.Rxyl_2913	3.203e-60	231.0	COG0687@1|root,COG0687@2|Bacteria,2GKVG@201174|Actinobacteria,4CQXF@84995|Rubrobacteria	84995|Rubrobacteria	E	Bacterial extracellular solute-binding protein	-	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_8
TLS1_k127_5980753_15	479434.Sthe_1277	5.352e-75	262.0	COG1176@1|root,COG1176@2|Bacteria,2G6E0@200795|Chloroflexi,27XNS@189775|Thermomicrobia	189775|Thermomicrobia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
TLS1_k127_5980753_19	526227.Mesil_1567	4.821e-66	250.0	COG1177@1|root,COG1177@2|Bacteria,1WI58@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	ABC-type spermidine putrescine transport system, permease component II	potC	-	-	ko:K11070	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
TLS1_k127_5980753_12	1183438.GKIL_0701	7.818e-94	330.0	COG4638@1|root,COG4638@2|Bacteria,1G6W8@1117|Cyanobacteria	1117|Cyanobacteria	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	-	ko:K00479	-	-	-	-	ko00000	-	-	-	Rieske,Ring_hydroxyl_A
TLS1_k127_5980753_2	42256.RradSPS_0629	3.873e-130	428.0	COG0404@1|root,COG0404@2|Bacteria,2I8C4@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the GcvT family	-	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1989,GCV_T,GCV_T_C
TLS1_k127_5980753_0	926550.CLDAP_16780	1.163e-208	690.0	COG5598@1|root,COG5598@2|Bacteria	2|Bacteria	H	trimethylamine methyltransferase	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
TLS1_k127_5980753_6	439235.Dalk_2789	2.101e-111	379.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,42N91@68525|delta/epsilon subdivisions,2WIMM@28221|Deltaproteobacteria,2MIKE@213118|Desulfobacterales	28221|Deltaproteobacteria	J	RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
TLS1_k127_5980753_3	309801.trd_A0395	1.682e-128	438.0	COG0109@1|root,COG1612@1|root,COG0109@2|Bacteria,COG1612@2|Bacteria,2G5UC@200795|Chloroflexi,27XHZ@189775|Thermomicrobia	189775|Thermomicrobia	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	COX15-CtaA,UbiA
TLS1_k127_5980753_29	867845.KI911784_gene2283	4.303e-28	125.0	COG0526@1|root,COG0526@2|Bacteria,2GACV@200795|Chloroflexi,375FU@32061|Chloroflexia	32061|Chloroflexia	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_2
TLS1_k127_5980753_24	479434.Sthe_0937	1.188e-46	180.0	COG0461@1|root,COG0461@2|Bacteria,2G6RG@200795|Chloroflexi,27YBT@189775|Thermomicrobia	189775|Thermomicrobia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	-	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
TLS1_k127_5980753_10	552811.Dehly_0067	1.036e-96	330.0	COG0167@1|root,COG0167@2|Bacteria,2G6RH@200795|Chloroflexi,34CMM@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
TLS1_k127_5980753_36	323850.Shew_2789	1.125e-06	61.0	2EP3D@1|root,33GQ5@2|Bacteria,1P237@1224|Proteobacteria,1SSJE@1236|Gammaproteobacteria,2QAQY@267890|Shewanellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
TLS1_k127_5980753_25	546273.VEIDISOL_01583	2.895e-43	170.0	COG0543@1|root,COG0543@2|Bacteria,1TQ5D@1239|Firmicutes,4H40K@909932|Negativicutes	909932|Negativicutes	C	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
TLS1_k127_5980753_17	1379270.AUXF01000003_gene3551	7.564e-69	255.0	COG0076@1|root,COG0076@2|Bacteria,1ZU8Z@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
TLS1_k127_5980753_27	1121946.AUAX01000001_gene2334	2.944e-35	152.0	COG1506@1|root,COG1506@2|Bacteria,2GZMV@201174|Actinobacteria,4DKND@85008|Micromonosporales	201174|Actinobacteria	E	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5980753_9	68219.JNXI01000056_gene870	2.043e-98	352.0	COG0665@1|root,COG0665@2|Bacteria,2GJQ9@201174|Actinobacteria	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
TLS1_k127_5980753_7	316274.Haur_4100	4.178e-103	355.0	COG0044@1|root,COG0044@2|Bacteria,2G640@200795|Chloroflexi,3755Y@32061|Chloroflexia	32061|Chloroflexia	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
TLS1_k127_5980753_8	357808.RoseRS_2863	7.822e-103	355.0	COG0540@1|root,COG0540@2|Bacteria,2G6GU@200795|Chloroflexi,376MF@32061|Chloroflexia	32061|Chloroflexia	F	PFAM aspartate ornithine carbamoyltransferase, Asp Orn-binding region	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
TLS1_k127_5980753_18	383372.Rcas_2433	7.35e-68	235.0	COG2065@1|root,COG2065@2|Bacteria,2G6WS@200795|Chloroflexi,375J4@32061|Chloroflexia	32061|Chloroflexia	F	Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
TLS1_k127_5980753_1	1246995.AFR_31800	2.744e-139	468.0	COG2141@1|root,COG2141@2|Bacteria,2GM94@201174|Actinobacteria,4DC29@85008|Micromonosporales	201174|Actinobacteria	C	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	fdg	-	1.1.98.2	ko:K15510	-	-	-	-	ko00000,ko01000	-	-	-	Bac_luciferase
TLS1_k127_5981457_2	1382356.JQMP01000004_gene471	1.144e-77	291.0	COG0472@1|root,COG0472@2|Bacteria,2G5TJ@200795|Chloroflexi,27Y23@189775|Thermomicrobia	189775|Thermomicrobia	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4
TLS1_k127_5981457_1	326427.Cagg_2847	1.373e-95	346.0	COG0770@1|root,COG0770@2|Bacteria,2G5PN@200795|Chloroflexi,374X6@32061|Chloroflexia	32061|Chloroflexia	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS1_k127_5981457_3	525904.Tter_1614	2.134e-71	264.0	COG0768@1|root,COG0768@2|Bacteria,2NNWR@2323|unclassified Bacteria	2|Bacteria	M	Penicillin-binding Protein dimerisation domain	ftsI	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681	3.4.16.4	ko:K03587,ko:K08384	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	iSSON_1240.SSON_0092	PASTA,PBP_dimer,Transpeptidase
TLS1_k127_5981457_0	1382356.JQMP01000004_gene475	7.783e-97	331.0	COG0275@1|root,COG0275@2|Bacteria,2G658@200795|Chloroflexi,27XI5@189775|Thermomicrobia	189775|Thermomicrobia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	-	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
TLS1_k127_5981457_4	1120973.AQXL01000130_gene1216	5.898e-35	139.0	COG2001@1|root,COG2001@2|Bacteria,1V3JD@1239|Firmicutes,4HH23@91061|Bacilli,278BK@186823|Alicyclobacillaceae	91061|Bacilli	K	Belongs to the MraZ family	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
TLS1_k127_5981457_5	273068.TTE1337	0.0001427	48.0	COG1388@1|root,COG1388@2|Bacteria,1V10C@1239|Firmicutes,25BB9@186801|Clostridia,42G9S@68295|Thermoanaerobacterales	186801|Clostridia	M	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
TLS1_k127_607430_8	926560.KE387027_gene351	1.281e-34	137.0	COG4832@1|root,COG4832@2|Bacteria	2|Bacteria	S	GyrI-like small molecule binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
TLS1_k127_607430_10	103690.17132947	2.833e-18	90.0	COG0517@1|root,COG0517@2|Bacteria,1G5TQ@1117|Cyanobacteria,1HN52@1161|Nostocales	1117|Cyanobacteria	S	PFAM CBS domain	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS
TLS1_k127_607430_4	749414.SBI_00971	1.404e-146	473.0	COG1595@1|root,COG1595@2|Bacteria,2GMRK@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2,SnoaL_2
TLS1_k127_607430_11	1463921.JODF01000008_gene5421	4.01e-11	68.0	2B42Y@1|root,31WTH@2|Bacteria,2INUX@201174|Actinobacteria	201174|Actinobacteria	S	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS_2
TLS1_k127_607430_0	479431.Namu_4792	3.942e-218	690.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4ETRQ@85013|Frankiales	201174|Actinobacteria	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	ko:K08167	-	M00713,M00714	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.3	-	-	MFS_1
TLS1_k127_607430_3	1121272.KB903252_gene1184	4.954e-180	576.0	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria,4D931@85008|Micromonosporales	201174|Actinobacteria	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
TLS1_k127_607430_2	1112217.PPL19_07331	1.044e-187	612.0	COG2115@1|root,COG2115@2|Bacteria,1MXS2@1224|Proteobacteria,1RN5Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the xylose isomerase family	xylA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0071704,GO:1901575	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	iECO26_1355.ECO26_5036,iPC815.YPO4038	-
TLS1_k127_607430_1	926569.ANT_24910	1.346e-191	622.0	COG1070@1|root,COG1070@2|Bacteria,2G5QX@200795|Chloroflexi	200795|Chloroflexi	G	PFAM carbohydrate kinase	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
TLS1_k127_607430_6	1040987.AZUY01000002_gene3832	1.542e-109	361.0	COG1129@1|root,COG1129@2|Bacteria,1P3ZB@1224|Proteobacteria,2VET1@28211|Alphaproteobacteria,43I52@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	ABC transporter	xylG	-	3.6.3.17	ko:K10545	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.4	-	-	ABC_tran
TLS1_k127_607430_5	472175.EL18_03130	2.193e-135	445.0	COG4214@1|root,COG4214@2|Bacteria,1MXXS@1224|Proteobacteria,2TR9B@28211|Alphaproteobacteria,43GUA@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Belongs to the binding-protein-dependent transport system permease family	xylH	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944	-	ko:K10544	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4	-	-	BPD_transp_2
TLS1_k127_607430_7	1532558.JL39_08905	4.807e-94	322.0	COG4213@1|root,COG4213@2|Bacteria,1MX63@1224|Proteobacteria,2TQQW@28211|Alphaproteobacteria,4B9MP@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	ABC transporter	xylF	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005975,GO:0005996,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0015749,GO:0015750,GO:0015753,GO:0019321,GO:0030246,GO:0030288,GO:0030313,GO:0031975,GO:0034219,GO:0036094,GO:0042597,GO:0042732,GO:0044238,GO:0044281,GO:0044464,GO:0048029,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704	-	ko:K10543	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4	-	-	Peripla_BP_4
TLS1_k127_607430_9	649831.L083_5320	6.974e-21	96.0	COG1940@1|root,COG1940@2|Bacteria,2GPEI@201174|Actinobacteria	201174|Actinobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	ROK
TLS1_k127_6084349_7	1449126.JQKL01000050_gene2673	8.812e-10	59.0	COG0050@1|root,COG0050@2|Bacteria,1TPKC@1239|Firmicutes,2485I@186801|Clostridia,267PG@186813|unclassified Clostridiales	186801|Clostridia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
TLS1_k127_6084349_6	1122609.AUGT01000017_gene872	1.715e-17	84.0	COG0267@1|root,COG0267@2|Bacteria,2GQFG@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
TLS1_k127_6084349_8	1499967.BAYZ01000113_gene2933	4.96e-07	55.0	COG0690@1|root,COG0690@2|Bacteria,2NQ1C@2323|unclassified Bacteria	2|Bacteria	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
TLS1_k127_6084349_2	1382306.JNIM01000001_gene88	5.611e-73	253.0	COG0250@1|root,COG0250@2|Bacteria,2G6A3@200795|Chloroflexi	200795|Chloroflexi	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
TLS1_k127_6084349_3	309801.trd_0681	8.797e-58	203.0	COG0080@1|root,COG0080@2|Bacteria,2G6FF@200795|Chloroflexi,27Y72@189775|Thermomicrobia	189775|Thermomicrobia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
TLS1_k127_6084349_1	264732.Moth_2471	4.408e-89	301.0	COG0081@1|root,COG0081@2|Bacteria,1TPTS@1239|Firmicutes,247JB@186801|Clostridia,42ETC@68295|Thermoanaerobacterales	186801|Clostridia	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
TLS1_k127_6084349_5	401526.TcarDRAFT_0988	4.048e-28	124.0	COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes,4H3ZQ@909932|Negativicutes	909932|Negativicutes	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
TLS1_k127_6084349_4	697281.Mahau_2165	1.721e-39	151.0	COG0222@1|root,COG0222@2|Bacteria,1V6EI@1239|Firmicutes,24JAC@186801|Clostridia,42GKP@68295|Thermoanaerobacterales	186801|Clostridia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
TLS1_k127_6084349_0	316274.Haur_0244	2.451e-288	904.0	COG0085@1|root,COG0085@2|Bacteria,2G5VH@200795|Chloroflexi,374ZB@32061|Chloroflexia	32061|Chloroflexia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
TLS1_k127_6084856_4	1283299.AUKG01000003_gene450	1.744e-60	224.0	COG1940@1|root,COG1940@2|Bacteria,2GJCQ@201174|Actinobacteria	201174|Actinobacteria	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
TLS1_k127_6084856_2	1382306.JNIM01000001_gene4155	5.719e-154	495.0	COG0057@1|root,COG0057@2|Bacteria,2G5MG@200795|Chloroflexi	200795|Chloroflexi	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
TLS1_k127_6084856_3	696369.KI912183_gene1961	1.077e-140	459.0	COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,248VS@186801|Clostridia,2605P@186807|Peptococcaceae	186801|Clostridia	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
TLS1_k127_6084856_1	324602.Caur_3808	2.71e-175	565.0	COG0148@1|root,COG0148@2|Bacteria,2G5VB@200795|Chloroflexi,375C2@32061|Chloroflexia	32061|Chloroflexia	F	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
TLS1_k127_6084856_5	1380763.BG53_02690	1.525e-06	60.0	COG0268@1|root,COG0268@2|Bacteria,1VEGX@1239|Firmicutes,4HNJS@91061|Bacilli,26Z41@186822|Paenibacillaceae	91061|Bacilli	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
TLS1_k127_6084856_6	1268068.PG5_07840	0.0004683	53.0	COG0697@1|root,COG0697@2|Bacteria,1NH2K@1224|Proteobacteria,1T17Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS1_k127_6084856_0	479434.Sthe_1219	1.379e-239	755.0	COG0481@1|root,COG0481@2|Bacteria,2G5K2@200795|Chloroflexi,27XM4@189775|Thermomicrobia	189775|Thermomicrobia	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
TLS1_k127_6205567_0	656024.FsymDg_0919	1.009e-153	509.0	COG0210@1|root,COG0210@2|Bacteria,2GKRW@201174|Actinobacteria,4ES82@85013|Frankiales	201174|Actinobacteria	L	PFAM UvrD REP helicase	uvrD2	GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0006996,GO:0008094,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0040007,GO:0042623,GO:0043167,GO:0043169,GO:0046872,GO:0051276,GO:0071103,GO:0071840,GO:0140097	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HRDC,UvrD-helicase,UvrD_C
TLS1_k127_6205567_12	1463895.JODA01000048_gene2877	0.0007766	51.0	COG2340@1|root,COG2340@2|Bacteria,2I39U@201174|Actinobacteria	201174|Actinobacteria	S	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP
TLS1_k127_6205567_9	2002.JOEQ01000001_gene4785	4.041e-12	79.0	COG4585@1|root,COG4585@2|Bacteria,2HDZV@201174|Actinobacteria,4EGKZ@85012|Streptosporangiales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS1_k127_6205567_7	1121356.AQUW01000009_gene2150	1.7e-20	103.0	COG2197@1|root,COG2197@2|Bacteria,2GJRY@201174|Actinobacteria,22JY1@1653|Corynebacteriaceae	201174|Actinobacteria	K	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	chrA	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS1_k127_6205567_8	479434.Sthe_0794	1.357e-13	84.0	COG3858@1|root,COG3858@2|Bacteria,2G7HP@200795|Chloroflexi,27XZM@189775|Thermomicrobia	189775|Thermomicrobia	S	PFAM glycoside hydrolase, family 18	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18
TLS1_k127_6205567_4	1121377.KB906428_gene1172	1.436e-70	261.0	COG3214@1|root,COG3214@2|Bacteria	2|Bacteria	J	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
TLS1_k127_6205567_11	1121272.KB903256_gene5661	1.723e-06	55.0	2C72U@1|root,32W8F@2|Bacteria,2GTSA@201174|Actinobacteria,4DG1X@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_6205567_5	1172179.AUKV01000023_gene2075	4.881e-43	166.0	COG3448@1|root,COG3448@2|Bacteria,2I3G0@201174|Actinobacteria	201174|Actinobacteria	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	BON,CBS
TLS1_k127_6205567_1	498761.HM1_1544	1.17e-109	370.0	COG3004@1|root,COG3004@2|Bacteria,1TS30@1239|Firmicutes,24AB3@186801|Clostridia	186801|Clostridia	P	) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
TLS1_k127_6205567_2	479434.Sthe_0414	4.999e-98	344.0	COG0358@1|root,COG0358@2|Bacteria,2G65X@200795|Chloroflexi,27XKY@189775|Thermomicrobia	189775|Thermomicrobia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_4,Toprim_N,zf-CHC2
TLS1_k127_6205567_10	574087.Acear_0693	2.164e-09	67.0	COG0568@1|root,COG0568@2|Bacteria,1TPD6@1239|Firmicutes,2481I@186801|Clostridia,3WABM@53433|Halanaerobiales	186801|Clostridia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS1_k127_6205584_7	479434.Sthe_0805	5.112e-67	237.0	COG1012@1|root,COG1012@2|Bacteria,2G5JZ@200795|Chloroflexi,27Y57@189775|Thermomicrobia	189775|Thermomicrobia	C	Belongs to the aldehyde dehydrogenase family	-	-	-	ko:K22187	ko00040,map00040	-	R11768	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
TLS1_k127_6205584_5	1202768.JROF01000001_gene1745	1.797e-75	267.0	COG1893@1|root,arCOG04139@2157|Archaea,2XW0P@28890|Euryarchaeota,23S7V@183963|Halobacteria	183963|Halobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
TLS1_k127_6205584_0	1128421.JAGA01000002_gene337	8.128e-139	452.0	COG0183@1|root,COG0183@2|Bacteria,2NNU9@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS1_k127_6205584_9	1122237.AUGQ01000010_gene2254	0.0001226	49.0	COG1396@1|root,COG1396@2|Bacteria,2GK9T@201174|Actinobacteria,4FSHT@85023|Microbacteriaceae	201174|Actinobacteria	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3,HTH_31
TLS1_k127_6205584_1	246194.CHY_1350	1.78e-113	381.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,42FF9@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Acyl-CoA dehydrogenase	bcd2	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,ETF_alpha,Rubredoxin
TLS1_k127_6205584_6	357808.RoseRS_3026	2.496e-74	282.0	COG0745@1|root,COG2203@1|root,COG2204@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,2G7Y4@200795|Chloroflexi,374VX@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase A domain protein	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA,PAS_4,Response_reg
TLS1_k127_6205584_4	1120705.FG95_00033	1.461e-75	263.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TR8E@28211|Alphaproteobacteria,2K0X2@204457|Sphingomonadales	204457|Sphingomonadales	I	Dehydrogenase	paaH	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
TLS1_k127_6205584_3	1122138.AQUZ01000015_gene6845	2.143e-76	271.0	COG0477@1|root,COG2814@2|Bacteria,2I8HS@201174|Actinobacteria,4DVK7@85009|Propionibacteriales	201174|Actinobacteria	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
TLS1_k127_6205584_2	1123024.AUII01000018_gene3837	7.625e-79	277.0	COG1703@1|root,COG1703@2|Bacteria,2GME8@201174|Actinobacteria,4DZZ0@85010|Pseudonocardiales	201174|Actinobacteria	E	ArgK protein	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
TLS1_k127_6205584_8	525904.Tter_1673	3.383e-55	196.0	COG2185@1|root,COG2185@2|Bacteria,2NPGA@2323|unclassified Bacteria	2|Bacteria	I	Cobalamin B12-binding	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
TLS1_k127_6263369_2	1380763.BG53_06035	7.588e-30	128.0	COG1092@1|root,COG1092@2|Bacteria,1TPUD@1239|Firmicutes,4HEUM@91061|Bacilli,26RBN@186822|Paenibacillaceae	91061|Bacilli	J	SAM-dependent methyltransferase	rumA1	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
TLS1_k127_6263369_3	443143.GM18_4316	8.766e-05	55.0	COG1404@1|root,COG1520@1|root,COG1404@2|Bacteria,COG1520@2|Bacteria,1MU3S@1224|Proteobacteria,42Q3Z@68525|delta/epsilon subdivisions,2WJPC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Belongs to the peptidase S8 family	-	-	3.4.21.66	ko:K08651	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	Big_2,CUB,He_PIG,Peptidase_S8
TLS1_k127_6263369_0	644966.Tmar_0825	1.445e-193	626.0	COG0441@1|root,COG0441@2|Bacteria,1TP78@1239|Firmicutes,248CH@186801|Clostridia,3WCD0@538999|Clostridiales incertae sedis	186801|Clostridia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
TLS1_k127_6263369_1	768706.Desor_0144	6.909e-49	187.0	COG0290@1|root,COG0290@2|Bacteria,1V1RC@1239|Firmicutes,24FUS@186801|Clostridia,260V8@186807|Peptococcaceae	186801|Clostridia	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
TLS1_k127_6281041_0	1007103.AFHW01000047_gene2861	1.394e-69	252.0	COG1653@1|root,COG1653@2|Bacteria,1TRIH@1239|Firmicutes,4HBRS@91061|Bacilli,26RI1@186822|Paenibacillaceae	91061|Bacilli	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
TLS1_k127_6281041_1	66874.JOFS01000003_gene7191	2.712e-58	213.0	COG1028@1|root,COG1028@2|Bacteria,2GMEH@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS1_k127_6281041_9	163908.KB235896_gene164	2.653e-11	78.0	COG0664@1|root,COG0664@2|Bacteria,1G57E@1117|Cyanobacteria,1HN55@1161|Nostocales	1117|Cyanobacteria	T	PFAM Cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
TLS1_k127_6281041_8	706587.Desti_2505	4.745e-14	87.0	COG0664@1|root,COG1413@1|root,COG3202@1|root,COG0664@2|Bacteria,COG1413@2|Bacteria,COG3202@2|Bacteria	2|Bacteria	C	ATP:ADP antiporter activity	CP_0465	-	-	ko:K15762	ko00623,ko00920,ko01100,ko01120,ko01220,map00623,map00920,map01100,map01120,map01220	M00538	R02550,R03562,R05666,R09513	RC00269,RC00490,RC02556	ko00000,ko00001,ko00002	-	-	-	HEAT_2,HTH_Crp_2,cNMP_binding
TLS1_k127_6281041_4	1122609.AUGT01000009_gene3394	1.149e-49	204.0	COG0457@1|root,COG0457@2|Bacteria,2IRQN@201174|Actinobacteria	201174|Actinobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_4
TLS1_k127_6281041_2	485913.Krac_4502	2.387e-57	213.0	COG1073@1|root,COG1073@2|Bacteria,2G8TK@200795|Chloroflexi	200795|Chloroflexi	S	Serine hydrolase	-	-	-	ko:K07002	-	-	-	-	ko00000	-	-	-	-
TLS1_k127_6281041_3	304371.MCP_2022	1.328e-51	192.0	COG1741@1|root,arCOG02935@2157|Archaea,2XTZ7@28890|Euryarchaeota	28890|Euryarchaeota	S	Belongs to the Pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
TLS1_k127_6281041_5	1459636.NTE_02189	4.745e-45	169.0	COG0262@1|root,arCOG01490@2157|Archaea	2157|Archaea	H	Belongs to the dihydrofolate reductase family	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS1_k127_6281041_7	1303518.CCALI_01363	3.471e-32	141.0	COG1597@1|root,COG1597@2|Bacteria	2|Bacteria	I	lipid kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
TLS1_k127_6281041_6	479434.Sthe_0331	1.32e-39	157.0	COG0671@1|root,COG0671@2|Bacteria,2G8YH@200795|Chloroflexi,27YK3@189775|Thermomicrobia	189775|Thermomicrobia	I	Acid phosphatase homologues	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
TLS1_k127_6290694_8	292459.STH124	9.793e-14	76.0	COG1920@1|root,COG1920@2|Bacteria,1V86Y@1239|Firmicutes,24K51@186801|Clostridia	186801|Clostridia	S	GTP binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_6290694_3	479434.Sthe_2425	1.116e-93	327.0	COG1565@1|root,COG1565@2|Bacteria,2G8NS@200795|Chloroflexi,27Y3B@189775|Thermomicrobia	189775|Thermomicrobia	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
TLS1_k127_6290694_7	1123511.KB905842_gene1662	5.964e-23	104.0	COG0838@1|root,COG0838@2|Bacteria,1V6P3@1239|Firmicutes,4H4KK@909932|Negativicutes	909932|Negativicutes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
TLS1_k127_6290694_5	1123511.KB905842_gene1663	8.844e-53	198.0	COG0377@1|root,COG0377@2|Bacteria,1TZS1@1239|Firmicutes,4H438@909932|Negativicutes	909932|Negativicutes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
TLS1_k127_6290694_6	871968.DESME_11520	5.17e-25	116.0	COG0852@1|root,COG0852@2|Bacteria,1UFNI@1239|Firmicutes,24GTJ@186801|Clostridia,262SJ@186807|Peptococcaceae	186801|Clostridia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
TLS1_k127_6290694_1	562970.Btus_3228	1.659e-103	357.0	COG0649@1|root,COG0649@2|Bacteria,1TQAR@1239|Firmicutes,4HA4Y@91061|Bacilli,278U3@186823|Alicyclobacillaceae	91061|Bacilli	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
TLS1_k127_6290694_4	1449063.JMLS01000022_gene6439	5.873e-83	293.0	COG1005@1|root,COG1005@2|Bacteria,1TQNU@1239|Firmicutes,4HC8R@91061|Bacilli,26T6C@186822|Paenibacillaceae	91061|Bacilli	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
TLS1_k127_6290694_9	1121918.ARWE01000001_gene416	2.398e-11	73.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,42R5T@68525|delta/epsilon subdivisions,2WMVQ@28221|Deltaproteobacteria,43THG@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
TLS1_k127_6290694_2	555079.Toce_0696	1.769e-95	331.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,42EM7@68295|Thermoanaerobacterales	186801|Clostridia	C	NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding	hymB	-	1.12.1.3,1.17.1.11,1.6.5.3	ko:K00335,ko:K18331,ko:K22339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
TLS1_k127_6290694_0	1382306.JNIM01000001_gene996	8.01e-176	580.0	COG0493@1|root,COG0493@2|Bacteria,2G82F@200795|Chloroflexi	200795|Chloroflexi	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Fer2_4,Fer4,Fer4_20,Pyr_redox_2
TLS1_k127_631236_6	926566.Terro_1124	3.356e-06	49.0	COG2217@1|root,COG2217@2|Bacteria,3Y39H@57723|Acidobacteria,2JHMU@204432|Acidobacteriia	204432|Acidobacteriia	P	heavy metal translocating P-type ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
TLS1_k127_631236_3	1380390.JIAT01000011_gene2575	2.148e-81	293.0	COG1177@1|root,COG1177@2|Bacteria,2GJ6Q@201174|Actinobacteria,4CQ2P@84995|Rubrobacteria	201174|Actinobacteria	E	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02053	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
TLS1_k127_631236_2	1380390.JIAT01000011_gene2576	1.787e-106	354.0	COG1176@1|root,COG1176@2|Bacteria,2GJ5G@201174|Actinobacteria,4CSJC@84995|Rubrobacteria	84995|Rubrobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
TLS1_k127_631236_0	1068978.AMETH_1082	1.715e-155	506.0	COG0687@1|root,COG0687@2|Bacteria,2HJ9K@201174|Actinobacteria,4DZXQ@85010|Pseudonocardiales	201174|Actinobacteria	E	Bacterial extracellular solute-binding protein	-	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_8
TLS1_k127_631236_1	2002.JOEQ01000024_gene196	1.943e-141	467.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4EFFE@85012|Streptosporangiales	201174|Actinobacteria	E	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
TLS1_k127_631236_5	1123366.TH3_18754	8.218e-09	64.0	COG4454@1|root,COG4454@2|Bacteria,1R91G@1224|Proteobacteria,2U6DH@28211|Alphaproteobacteria,2JSVB@204441|Rhodospirillales	204441|Rhodospirillales	P	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
TLS1_k127_631236_4	1121928.AUHE01000007_gene1170	1.619e-27	118.0	COG1146@1|root,COG1146@2|Bacteria,2IKVN@201174|Actinobacteria,4GEJW@85026|Gordoniaceae	201174|Actinobacteria	C	4Fe-4S binding domain	fdxA	GO:0001666,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0009605,GO:0009607,GO:0009628,GO:0036293,GO:0043207,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0070482,GO:0075136	-	-	-	-	-	-	-	-	-	-	Fer4
TLS1_k127_6316768_17	1041147.AUFB01000016_gene1226	6.076e-09	65.0	COG4961@1|root,COG4961@2|Bacteria,1QV5Z@1224|Proteobacteria,2TWAQ@28211|Alphaproteobacteria,4BP1W@82115|Rhizobiaceae	28211|Alphaproteobacteria	U	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
TLS1_k127_6316768_11	314230.DSM3645_29172	7.628e-55	202.0	COG2135@1|root,COG2135@2|Bacteria,2IZYY@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
TLS1_k127_6316768_13	1487921.DP68_03770	1.12e-25	121.0	COG0705@1|root,COG0705@2|Bacteria,1TQXT@1239|Firmicutes,247PT@186801|Clostridia,36H7U@31979|Clostridiaceae	186801|Clostridia	S	Rhomboid family	gluP	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Rhomboid
TLS1_k127_6316768_9	1304865.JAGF01000001_gene2446	7.471e-64	228.0	29JD5@1|root,306AN@2|Bacteria,2I9J8@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_6316768_8	58123.JOFJ01000014_gene5035	5.275e-66	237.0	COG0697@1|root,COG0697@2|Bacteria,2IH82@201174|Actinobacteria	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS1_k127_6316768_16	522772.Dacet_0422	6.347e-12	68.0	COG0298@1|root,COG0298@2|Bacteria,2GG1Z@200930|Deferribacteres	200930|Deferribacteres	O	HupF/HypC family	-	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
TLS1_k127_6316768_18	1223521.BBJX01000007_gene1438	3.143e-07	61.0	COG0680@1|root,COG0680@2|Bacteria,1MZE1@1224|Proteobacteria,2VTPX@28216|Betaproteobacteria,4AFG9@80864|Comamonadaceae	28216|Betaproteobacteria	C	hydrogenase maturation protease	hoxW	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_6316768_1	314278.NB231_04665	4.83e-140	459.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,1T20U@1236|Gammaproteobacteria,1WY2T@135613|Chromatiales	135613|Chromatiales	C	PFAM Nickel-dependent hydrogenase, large subunit	-	-	-	-	-	-	-	-	-	-	-	-	NiFeSe_Hases
TLS1_k127_6316768_5	711393.AYRX01000115_gene5615	5.384e-75	282.0	COG1941@1|root,COG1941@2|Bacteria,2GSPN@201174|Actinobacteria	201174|Actinobacteria	C	NADH ubiquinone oxidoreductase, 20	-	-	1.12.1.2	ko:K18007	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_q6
TLS1_k127_6316768_2	391625.PPSIR1_39870	6.095e-137	460.0	COG0479@1|root,COG0543@1|root,COG0479@2|Bacteria,COG0543@2|Bacteria,1QVWG@1224|Proteobacteria,43BWA@68525|delta/epsilon subdivisions,2X771@28221|Deltaproteobacteria,2YUJP@29|Myxococcales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
TLS1_k127_6316768_19	1150599.MPHLEI_26877	2.02e-05	57.0	2BVHN@1|root,32QW3@2|Bacteria,2IKWS@201174|Actinobacteria,2397E@1762|Mycobacteriaceae	201174|Actinobacteria	S	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
TLS1_k127_6316768_7	326427.Cagg_0972	1.383e-68	238.0	COG2080@1|root,COG2080@2|Bacteria,2G6NT@200795|Chloroflexi,3764A@32061|Chloroflexia	32061|Chloroflexia	C	2Fe-2S -binding domain protein	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
TLS1_k127_6316768_0	383372.Rcas_0842	0.0	1042.0	COG1529@1|root,COG1529@2|Bacteria,2G608@200795|Chloroflexi,376SU@32061|Chloroflexia	32061|Chloroflexia	C	PFAM aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS1_k127_6316768_10	479434.Sthe_1400	1.536e-55	220.0	COG1319@1|root,COG1319@2|Bacteria,2G60Y@200795|Chloroflexi,27XP9@189775|Thermomicrobia	189775|Thermomicrobia	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
TLS1_k127_6316768_12	525904.Tter_1417	3.35e-47	183.0	COG0303@1|root,COG0303@2|Bacteria,2NR4P@2323|unclassified Bacteria	2|Bacteria	H	'Molybdopterin	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_6316768_3	357808.RoseRS_2166	2.61e-108	388.0	COG0714@1|root,COG0714@2|Bacteria,2G5WI@200795|Chloroflexi,37710@32061|Chloroflexia	32061|Chloroflexia	S	PFAM ATPase associated with various cellular activities, AAA_5	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
TLS1_k127_6316768_4	479434.Sthe_1402	3.211e-89	317.0	COG3552@1|root,COG3552@2|Bacteria,2G5IW@200795|Chloroflexi,27XNE@189775|Thermomicrobia	189775|Thermomicrobia	S	VWA domain containing CoxE-like protein	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
TLS1_k127_6316768_6	525904.Tter_2236	5.265e-73	273.0	COG1975@1|root,COG1975@2|Bacteria,2NPTS@2323|unclassified Bacteria	2|Bacteria	O	XdhC and CoxI family	pucA	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
TLS1_k127_6316768_14	864069.MicloDRAFT_00044680	2.404e-22	112.0	COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,2TR5D@28211|Alphaproteobacteria,1JUR5@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
TLS1_k127_6316768_15	1128421.JAGA01000001_gene2440	1.711e-20	106.0	COG2265@1|root,COG2265@2|Bacteria,2NRDB@2323|unclassified Bacteria	2|Bacteria	J	Methyltransferase domain	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	Methyltransf_21,Methyltransf_25,Methyltransf_31
TLS1_k127_6317270_7	1343740.M271_12690	5.816e-80	284.0	COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.17.1.9,1.6.5.3	ko:K00122,ko:K00335	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
TLS1_k127_6317270_15	1449347.JQLN01000003_gene5808	3.594e-44	176.0	COG0346@1|root,COG0346@2|Bacteria,2IMDZ@201174|Actinobacteria,2M3Y8@2063|Kitasatospora	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K07032	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS1_k127_6317270_0	1122611.KB903977_gene2806	4.493e-241	756.0	COG3383@1|root,COG3383@2|Bacteria,2HC9H@201174|Actinobacteria,4EGXK@85012|Streptosporangiales	201174|Actinobacteria	C	Molybdopterin oxidoreductase	fdnG	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdopterin,Molydop_binding
TLS1_k127_6317270_22	67267.JNXT01000012_gene484	3.688e-25	119.0	COG3383@1|root,COG3383@2|Bacteria,2HC9H@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	fdnG	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdopterin,Molydop_binding
TLS1_k127_6317270_10	926569.ANT_31600	2.288e-64	231.0	arCOG06481@1|root,2ZB4E@2|Bacteria,2G82Q@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_6317270_16	498848.TaqDRAFT_4331	1.767e-41	164.0	COG1404@1|root,COG1404@2|Bacteria,1WJ4U@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	Domain of unknown function (DUF4397)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4397
TLS1_k127_6317270_8	926569.ANT_27040	9.482e-72	252.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	ycdQ	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glycos_transf_2
TLS1_k127_6317270_6	479434.Sthe_0838	3.11e-84	295.0	COG0709@1|root,COG0709@2|Bacteria,2G5W4@200795|Chloroflexi,27XGA@189775|Thermomicrobia	189775|Thermomicrobia	H	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
TLS1_k127_6317270_4	324602.Caur_1021	6.368e-104	361.0	COG1921@1|root,COG1921@2|Bacteria,2G5VV@200795|Chloroflexi,376BM@32061|Chloroflexia	32061|Chloroflexia	H	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
TLS1_k127_6317270_5	479434.Sthe_1974	2.03e-87	314.0	COG3276@1|root,COG3276@2|Bacteria,2G5JX@200795|Chloroflexi,27XRW@189775|Thermomicrobia	189775|Thermomicrobia	J	Elongation factor SelB, winged helix	-	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
TLS1_k127_6317270_24	1385518.N798_01690	4.469e-12	78.0	COG0746@1|root,COG0746@2|Bacteria,2HXM8@201174|Actinobacteria,4FHCJ@85021|Intrasporangiaceae	201174|Actinobacteria	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3
TLS1_k127_6317270_1	68194.JNXR01000030_gene2459	3.552e-194	625.0	COG1574@1|root,COG1574@2|Bacteria,2GJVW@201174|Actinobacteria	201174|Actinobacteria	E	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
TLS1_k127_6317270_12	1463853.JOHW01000008_gene818	6.494e-55	198.0	COG0491@1|root,COG0491@2|Bacteria,2GJ6X@201174|Actinobacteria	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS1_k127_6317270_9	222534.KB893783_gene5229	1.97e-68	241.0	COG4106@1|root,COG4106@2|Bacteria,2GJMG@201174|Actinobacteria,4ESQ9@85013|Frankiales	201174|Actinobacteria	S	Methyltransferase small domain	-	-	2.1.1.144	ko:K00598	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_25
TLS1_k127_6317270_26	1056816.JAFQ01000004_gene1635	0.0001582	55.0	COG1714@1|root,COG1714@2|Bacteria,2GS9U@201174|Actinobacteria,4G38W@85025|Nocardiaceae	201174|Actinobacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
TLS1_k127_6317270_2	926560.KE387027_gene419	6.418e-159	518.0	COG0477@1|root,COG0477@2|Bacteria,1WMC1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS1_k127_6317270_23	926569.ANT_25530	1.984e-21	109.0	COG4242@1|root,COG4242@2|Bacteria	2|Bacteria	PQ	Belongs to the peptidase S51 family	cphB	-	3.4.15.6	ko:K13282	-	-	R09722	RC00064,RC00141	ko00000,ko01000,ko01002	-	-	-	Peptidase_S51
TLS1_k127_6317270_20	479434.Sthe_2339	1.197e-28	119.0	COG1278@1|root,COG1278@2|Bacteria,2G79W@200795|Chloroflexi,27YHA@189775|Thermomicrobia	189775|Thermomicrobia	K	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
TLS1_k127_6317270_18	269799.Gmet_1223	4.544e-33	143.0	COG0420@1|root,COG0420@2|Bacteria,1MXMJ@1224|Proteobacteria,42Q5U@68525|delta/epsilon subdivisions,2WINF@28221|Deltaproteobacteria,43SKW@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Calcineurin-like phosphoesterase	sbcD-1	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,Metallophos_2
TLS1_k127_6317270_21	401526.TcarDRAFT_1987	2.583e-25	123.0	COG0419@1|root,COG0419@2|Bacteria,1UI2P@1239|Firmicutes,4H37A@909932|Negativicutes	909932|Negativicutes	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_23,AAA_27
TLS1_k127_6317270_13	404589.Anae109_2816	1.215e-54	203.0	COG0697@1|root,COG0697@2|Bacteria,1R03B@1224|Proteobacteria,42S5I@68525|delta/epsilon subdivisions,2WNXS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS1_k127_6317270_3	1380390.JIAT01000009_gene1628	1.423e-147	506.0	COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS1_k127_6317270_19	1157632.AQWQ01000015_gene3456	8.285e-32	130.0	COG0639@1|root,COG4639@1|root,COG0639@2|Bacteria,COG4639@2|Bacteria,2GMB5@201174|Actinobacteria	201174|Actinobacteria	T	PFAM Metallophosphoesterase	prpA	-	3.1.3.16	ko:K01090	-	-	-	-	ko00000,ko01000	-	-	-	AAA_33,Metallophos,PNKP-ligase_C,PNKP_ligase
TLS1_k127_6317270_25	1121360.AUAQ01000017_gene2537	0.0001298	51.0	COG2154@1|root,COG2154@2|Bacteria,2IHS3@201174|Actinobacteria,22N46@1653|Corynebacteriaceae	201174|Actinobacteria	H	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS1_k127_6317270_14	1045009.AFXQ01000011_gene480	3.595e-51	192.0	COG2146@1|root,COG2146@2|Bacteria,2I1BQ@201174|Actinobacteria,1W7ZZ@1268|Micrococcaceae	201174|Actinobacteria	P	Rieske-like [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231,Rieske
TLS1_k127_6317270_11	1111479.AXAR01000004_gene2214	1.329e-59	224.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	fsr	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1
TLS1_k127_6317270_17	1380370.JIBA01000003_gene2736	6.841e-39	153.0	2F7A3@1|root,33ZRB@2|Bacteria,2IRS4@201174|Actinobacteria,4FIVD@85021|Intrasporangiaceae	201174|Actinobacteria	S	Pfam:DUF2029	-	-	-	-	-	-	-	-	-	-	-	-	GT87
TLS1_k127_6338300_4	555088.DealDRAFT_1304	2.828e-19	98.0	COG2909@1|root,COG3947@1|root,COG2909@2|Bacteria,COG3947@2|Bacteria,1UIMV@1239|Firmicutes,25GAH@186801|Clostridia	186801|Clostridia	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD
TLS1_k127_6338300_7	502558.EGYY_10530	6.605e-14	83.0	COG0682@1|root,COG0682@2|Bacteria,2GKSS@201174|Actinobacteria,4CUQA@84998|Coriobacteriia	84998|Coriobacteriia	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
TLS1_k127_6338300_0	526227.Mesil_1872	4.666e-254	792.0	COG1012@1|root,COG1012@2|Bacteria,1WJFH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Aldehyde dehydrogenase family	-	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS1_k127_6338300_6	471853.Bcav_1990	1.42e-14	78.0	2E3KN@1|root,32YIY@2|Bacteria,2GQXH@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF2630)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2630
TLS1_k127_6338300_3	593750.Metfor_1976	1.652e-48	190.0	COG2208@1|root,arCOG02362@1|root,arCOG02362@2157|Archaea,arCOG06893@2157|Archaea,2Y2MD@28890|Euryarchaeota	2157|Archaea	T	Stage II sporulation protein E	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,SpoIIE,dCache_1
TLS1_k127_6338300_10	446468.Ndas_5267	1.312e-09	64.0	COG1366@1|root,COG1366@2|Bacteria,2IHP9@201174|Actinobacteria,4EK6E@85012|Streptosporangiales	201174|Actinobacteria	T	STAS domain	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
TLS1_k127_6338300_8	1150469.RSPPHO_00369	1.694e-13	84.0	COG2172@1|root,COG2172@2|Bacteria,1N9RD@1224|Proteobacteria,2UCGB@28211|Alphaproteobacteria,2JTM5@204441|Rhodospirillales	204441|Rhodospirillales	T	Histidine kinase-like ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2
TLS1_k127_6338300_1	1463887.KL589953_gene107	8.184e-198	626.0	COG0044@1|root,COG0044@2|Bacteria,2GK4A@201174|Actinobacteria	201174|Actinobacteria	F	Dihydropyrimidinase	hydA	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
TLS1_k127_6338300_2	485913.Krac_11396	2.837e-110	367.0	COG2141@1|root,COG2141@2|Bacteria	2|Bacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS1_k127_6338300_5	479432.Sros_9084	3.851e-16	83.0	COG3631@1|root,COG3631@2|Bacteria,2GRE5@201174|Actinobacteria,4EQUU@85012|Streptosporangiales	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	ko:K06893	-	-	-	-	ko00000	-	-	-	SnoaL_2
TLS1_k127_6338300_9	935839.JAGJ01000010_gene395	1.289e-12	67.0	COG0388@1|root,COG0388@2|Bacteria,2GKRJ@201174|Actinobacteria	201174|Actinobacteria	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.6	ko:K01431	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R00905,R04666,R08228	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase
TLS1_k127_6342546_1	1125863.JAFN01000001_gene2796	1.733e-106	371.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42PJ7@68525|delta/epsilon subdivisions,2WMEM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,Pyr_redox_2
TLS1_k127_6342546_10	1382356.JQMP01000003_gene2153	1.65e-52	203.0	COG2120@1|root,COG2120@2|Bacteria,2G6FB@200795|Chloroflexi,27XV7@189775|Thermomicrobia	189775|Thermomicrobia	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
TLS1_k127_6342546_11	1128421.JAGA01000004_gene2555	3.365e-49	191.0	COG1225@1|root,COG1225@2|Bacteria,2NPEE@2323|unclassified Bacteria	2|Bacteria	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	bcp	-	1.11.1.15,2.7.7.42,2.7.7.89	ko:K00982,ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
TLS1_k127_6342546_16	316274.Haur_2676	1.447e-33	139.0	COG1564@1|root,COG1564@2|Bacteria,2G6VK@200795|Chloroflexi,375VW@32061|Chloroflexia	32061|Chloroflexia	H	PFAM Thiamin pyrophosphokinase, catalytic region	-	-	2.7.6.2	ko:K00949	ko00730,ko01100,map00730,map01100	-	R00619	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TPK_B1_binding,TPK_catalytic
TLS1_k127_6342546_19	693986.MOC_5109	1.326e-16	93.0	COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,2U79T@28211|Alphaproteobacteria,1JV1M@119045|Methylobacteriaceae	28211|Alphaproteobacteria	G	subfamily IA, variant 1	cbbZ	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS1_k127_6342546_18	58344.JOEL01000015_gene6350	6.795e-31	128.0	COG2606@1|root,COG2606@2|Bacteria,2IKUX@201174|Actinobacteria	201174|Actinobacteria	S	YbaK prolyl-tRNA synthetase associated region	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
TLS1_k127_6342546_12	525904.Tter_0442	4.166e-45	189.0	COG2202@1|root,COG2203@1|root,COG5001@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG5001@2|Bacteria,2NP1A@2323|unclassified Bacteria	2|Bacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GAF_2,GGDEF,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,PilZ,Response_reg
TLS1_k127_6342546_14	204669.Acid345_3659	1.265e-37	164.0	COG2199@1|root,COG2203@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,3Y40V@57723|Acidobacteria,2JI0P@204432|Acidobacteriia	204432|Acidobacteriia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GGDEF
TLS1_k127_6342546_15	666686.B1NLA3E_10920	1.514e-35	150.0	COG0726@1|root,COG0726@2|Bacteria,1V6DN@1239|Firmicutes,4HEPH@91061|Bacilli,1ZC54@1386|Bacillus	91061|Bacilli	G	Polysaccharide deacetylase	cda1	GO:0005575,GO:0016020	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	CBM_6,DUF3298,DUF4163,Polysacc_deac_1
TLS1_k127_6342546_17	926550.CLDAP_24350	1.219e-32	139.0	COG2071@1|root,COG2071@2|Bacteria,2G6QN@200795|Chloroflexi	200795|Chloroflexi	S	PFAM glutamine amidotransferase class-I	-	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
TLS1_k127_6342546_3	66429.JOFL01000003_gene3246	1.339e-92	328.0	COG1126@1|root,COG1126@2|Bacteria,2GIZW@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter, ATP-binding protein	-	-	3.6.3.21	ko:K02028,ko:K02029	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
TLS1_k127_6342546_4	479432.Sros_9352	1.319e-84	289.0	COG0765@1|root,COG0765@2|Bacteria,2GM0I@201174|Actinobacteria,4EGKS@85012|Streptosporangiales	201174|Actinobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02029,ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1,DUF2808,SBP_bac_3
TLS1_k127_6342546_6	469371.Tbis_3557	2.632e-77	273.0	COG0834@1|root,COG0834@2|Bacteria,2GN3G@201174|Actinobacteria,4E28R@85010|Pseudonocardiales	201174|Actinobacteria	ET	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K02030,ko:K02424,ko:K17073	ko02010,map02010	M00234,M00236,M00589	-	-	ko00000,ko00001,ko00002,ko02000,ko02035	3.A.1.3,3.A.1.3.10,3.A.1.3.14,3.A.1.3.20	-	-	SBP_bac_3
TLS1_k127_6342546_8	1394178.AWOO02000025_gene5013	1.957e-68	246.0	COG1912@1|root,COG1912@2|Bacteria,2IASJ@201174|Actinobacteria,4EFY5@85012|Streptosporangiales	201174|Actinobacteria	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
TLS1_k127_6342546_9	525904.Tter_0552	3.156e-67	241.0	COG2378@1|root,COG2378@2|Bacteria,2NPY6@2323|unclassified Bacteria	2|Bacteria	K	WYL domain	-	-	-	ko:K07012,ko:K13572	-	-	-	-	ko00000,ko01000,ko02048,ko03051	-	-	-	DEAD,HD,HTH_11,WYL
TLS1_k127_6342546_5	330214.NIDE3049	5.565e-84	307.0	COG1078@1|root,COG1078@2|Bacteria,3J0YB@40117|Nitrospirae	40117|Nitrospirae	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
TLS1_k127_6342546_20	931626.Awo_c25390	5.162e-12	76.0	COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,248ZG@186801|Clostridia,25W1V@186806|Eubacteriaceae	186801|Clostridia	D	Psort location Extracellular, score	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
TLS1_k127_6342546_7	436229.JOEH01000019_gene6607	2.804e-76	282.0	COG1136@1|root,COG1136@2|Bacteria,2GJQV@201174|Actinobacteria,2NF4I@228398|Streptacidiphilus	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS1_k127_6342546_2	28444.JODQ01000001_gene2598	2.489e-101	370.0	COG1136@1|root,COG1136@2|Bacteria,2GIV7@201174|Actinobacteria,4EGJX@85012|Streptosporangiales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS1_k127_6342546_13	28444.JODQ01000001_gene2597	1.482e-42	181.0	COG0577@1|root,COG0577@2|Bacteria,2GNEX@201174|Actinobacteria,4EI9Q@85012|Streptosporangiales	201174|Actinobacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
TLS1_k127_6342546_0	28444.JODQ01000001_gene2596	1.084e-117	418.0	COG0577@1|root,COG0577@2|Bacteria,2H997@201174|Actinobacteria,4EGB7@85012|Streptosporangiales	201174|Actinobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
TLS1_k127_6345079_0	1111479.AXAR01000006_gene806	4.931e-108	358.0	COG1028@1|root,COG1028@2|Bacteria,1TSWA@1239|Firmicutes,4HBHR@91061|Bacilli	91061|Bacilli	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS1_k127_6345079_4	485913.Krac_5470	7.275e-31	132.0	COG0666@1|root,COG0666@2|Bacteria,2G9PM@200795|Chloroflexi	200795|Chloroflexi	S	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_6345079_2	1210046.B277_03655	1.337e-61	229.0	COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,2HXQA@201174|Actinobacteria,4FHIS@85021|Intrasporangiaceae	201174|Actinobacteria	K	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2,MerR_1
TLS1_k127_6345079_6	1158602.I590_02927	1.06e-09	62.0	COG2155@1|root,COG2155@2|Bacteria,1VEQJ@1239|Firmicutes,4HP56@91061|Bacilli,4B406@81852|Enterococcaceae	91061|Bacilli	S	Domain of unknown function (DUF378)	-	-	-	ko:K09779	-	-	-	-	ko00000	-	-	-	DUF378
TLS1_k127_6345079_5	404589.Anae109_0807	2.965e-30	136.0	COG4276@1|root,COG4276@2|Bacteria,1N6EC@1224|Proteobacteria,42U3N@68525|delta/epsilon subdivisions,2WQTN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Pfam Polyketide cyclase dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
TLS1_k127_6345079_1	292459.STH404	1.069e-81	290.0	COG0702@1|root,COG0702@2|Bacteria,1VEC8@1239|Firmicutes,25BCI@186801|Clostridia	186801|Clostridia	GM	NmrA-like family	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	NAD_binding_10
TLS1_k127_6345079_3	1079460.ATTQ01000004_gene1797	1.745e-41	169.0	COG3850@1|root,COG5001@1|root,COG3850@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2UQAK@28211|Alphaproteobacteria,4B728@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,PAS,PAS_9
TLS1_k127_6427098_0	324602.Caur_3445	4.455e-107	368.0	COG0490@1|root,COG1226@1|root,COG4651@1|root,COG0490@2|Bacteria,COG1226@2|Bacteria,COG4651@2|Bacteria,2G5QY@200795|Chloroflexi,376DS@32061|Chloroflexia	32061|Chloroflexia	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
TLS1_k127_6427098_1	1348663.KCH_47580	5.225e-71	248.0	COG1940@1|root,COG1940@2|Bacteria,2GJA0@201174|Actinobacteria,2M2A0@2063|Kitasatospora	201174|Actinobacteria	GK	ROK family	ppgK	-	2.7.1.2,2.7.1.63	ko:K00845,ko:K00886	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786,R02187,R02189	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
TLS1_k127_6447998_3	1229780.BN381_160007	1.756e-18	95.0	COG1034@1|root,COG1034@2|Bacteria,2GJGX@201174|Actinobacteria,3UWBF@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	nuoG	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009405,GO:0010941,GO:0016020,GO:0016491,GO:0016651,GO:0030312,GO:0033668,GO:0035821,GO:0042981,GO:0043067,GO:0043069,GO:0044003,GO:0044068,GO:0044403,GO:0044419,GO:0044464,GO:0044531,GO:0044532,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051536,GO:0051540,GO:0051701,GO:0051704,GO:0051817,GO:0052040,GO:0052041,GO:0052150,GO:0052248,GO:0052433,GO:0052490,GO:0055114,GO:0060548,GO:0065007,GO:0071944	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
TLS1_k127_6447998_4	717785.HYPMC_0101	9.638e-07	58.0	COG3187@1|root,COG3187@2|Bacteria,1NGG1@1224|Proteobacteria,2UJJM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	META domain	-	-	-	-	-	-	-	-	-	-	-	-	META
TLS1_k127_6447998_2	1206741.BAFX01000054_gene2331	2.136e-30	135.0	COG0328@1|root,COG0406@1|root,COG0328@2|Bacteria,COG0406@2|Bacteria,2GJ9R@201174|Actinobacteria,4FX7S@85025|Nocardiaceae	201174|Actinobacteria	GL	Reverse transcriptase-like	rnhA	GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576	3.1.26.4,3.1.3.73	ko:K02226,ko:K22316	ko00860,ko01100,ko03030,map00860,map01100,map03030	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	His_Phos_1,RVT_3
TLS1_k127_6447998_1	869210.Marky_1615	1.468e-102	340.0	COG0479@1|root,COG0479@2|Bacteria,1WIEW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_10,Fer4_8
TLS1_k127_6447998_0	1449058.JQKT01000010_gene2118	1.116e-187	598.0	COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria,4FKH0@85023|Microbacteriaceae	201174|Actinobacteria	C	Fumarate reductase flavoprotein C-term	sdhA	GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363	1.3.5.1,1.3.5.4,1.4.3.16	ko:K00239,ko:K00278	ko00020,ko00190,ko00250,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00250,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00115,M00149,M00173,M00374,M00376	R00357,R00481,R02164	RC00006,RC00045,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TLS1_k127_6474438_0	1380390.JIAT01000009_gene1628	1.07e-155	530.0	COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS1_k127_6474438_1	580327.Tthe_1660	1.098e-116	391.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,42FF9@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Acyl-CoA dehydrogenase	bcd	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016627,GO:0016628,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363	1.3.1.108,1.3.8.1	ko:K00248,ko:K22430	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS1_k127_6474438_2	1536772.R70723_11280	2.057e-31	132.0	COG2345@1|root,COG2345@2|Bacteria,1V3GF@1239|Firmicutes,4HG9G@91061|Bacilli,275GJ@186822|Paenibacillaceae	91061|Bacilli	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_20
TLS1_k127_6474438_3	1297742.A176_04485	2.438e-26	112.0	COG1816@1|root,COG1816@2|Bacteria,1MWBV@1224|Proteobacteria	1224|Proteobacteria	F	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism	add	GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009156,GO:0009161,GO:0009163,GO:0009164,GO:0009165,GO:0009167,GO:0009168,GO:0009987,GO:0015949,GO:0015950,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0032261,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0043173,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	iSFV_1184.SFV_1640,iSF_1195.SF1648,iSFxv_1172.SFxv_1849,iS_1188.S1780	A_deaminase
TLS1_k127_6541544_0	479435.Kfla_5618	1.376e-128	420.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4DNPQ@85009|Propionibacteriales	201174|Actinobacteria	V	daunorubicin resistance ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS1_k127_6541544_2	585531.HMPREF0063_11034	1.775e-73	269.0	COG0842@1|root,COG0842@2|Bacteria,2GKJF@201174|Actinobacteria,4DQ35@85009|Propionibacteriales	201174|Actinobacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS1_k127_6541544_1	469383.Cwoe_3826	2.976e-101	354.0	COG2197@1|root,COG2206@1|root,COG2197@2|Bacteria,COG2206@2|Bacteria,2GJS8@201174|Actinobacteria	201174|Actinobacteria	T	metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,HD_5
TLS1_k127_6541544_4	235985.BBPN01000011_gene4207	1.328e-24	111.0	COG2867@1|root,COG2867@2|Bacteria,2IIFW@201174|Actinobacteria,2NMJJ@228398|Streptacidiphilus	201174|Actinobacteria	I	negative regulation of translational initiation	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS1_k127_6541544_3	1469948.JPNB01000001_gene1421	3.684e-28	115.0	28HXF@1|root,2Z834@2|Bacteria,1UCHQ@1239|Firmicutes,24DZQ@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_658880_1	926569.ANT_28860	2.168e-138	473.0	COG1198@1|root,COG1198@2|Bacteria,2G60J@200795|Chloroflexi	200795|Chloroflexi	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
TLS1_k127_658880_4	1382306.JNIM01000001_gene1293	4.657e-39	162.0	COG0194@1|root,COG0194@2|Bacteria,2G6EW@200795|Chloroflexi	200795|Chloroflexi	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
TLS1_k127_658880_2	429009.Adeg_1604	1.147e-78	285.0	COG0564@1|root,COG0564@2|Bacteria,1TPCM@1239|Firmicutes,247Y2@186801|Clostridia,42F72@68295|Thermoanaerobacterales	186801|Clostridia	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS1_k127_658880_5	1121439.dsat_1508	3.655e-20	104.0	COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,42UAT@68525|delta/epsilon subdivisions,2WQ31@28221|Deltaproteobacteria,2MB6W@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
TLS1_k127_658880_0	479434.Sthe_0337	0.0	1097.0	COG0060@1|root,COG0060@2|Bacteria,2G5SN@200795|Chloroflexi,27XEH@189775|Thermomicrobia	189775|Thermomicrobia	J	Anticodon-binding domain of tRNA	-	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
TLS1_k127_658880_3	1382356.JQMP01000003_gene1423	2.238e-48	193.0	COG1316@1|root,COG1316@2|Bacteria,2G6PZ@200795|Chloroflexi,27XRZ@189775|Thermomicrobia	189775|Thermomicrobia	K	cell envelope-related transcriptional attenuator	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
TLS1_k127_6622499_0	290397.Adeh_2624	1.211e-74	262.0	COG1216@1|root,COG1216@2|Bacteria,1QX3U@1224|Proteobacteria,42RP8@68525|delta/epsilon subdivisions,2WNF5@28221|Deltaproteobacteria,2Z30X@29|Myxococcales	28221|Deltaproteobacteria	S	Glycosyltransferase like family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
TLS1_k127_6622499_2	1120954.ATXE01000003_gene585	2.297e-37	164.0	COG0726@1|root,COG4886@1|root,COG5479@1|root,COG0726@2|Bacteria,COG4886@2|Bacteria,COG5479@2|Bacteria,2I6Q0@201174|Actinobacteria,4DX27@85009|Propionibacteriales	201174|Actinobacteria	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	LGFP,Peptidase_M15_4
TLS1_k127_6622499_1	880073.Calab_0133	1.322e-37	165.0	COG0860@1|root,COG1361@1|root,COG3858@1|root,COG0860@2|Bacteria,COG1361@2|Bacteria,COG3858@2|Bacteria,2NQII@2323|unclassified Bacteria	2|Bacteria	M	Glyco_18	-	-	3.4.17.14,3.5.1.28	ko:K01448,ko:K07260,ko:K20276	ko00550,ko01100,ko01502,ko01503,ko02020,ko02024,map00550,map01100,map01502,map01503,map02020,map02024	M00651,M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko03036	-	-	-	Amidase_3,CHAP,CW_binding_2,Cu_amine_oxidN1,GBS_Bsp-like,Glyco_hydro_18,Glyco_hydro_25,Peptidase_C39_2,SH3_5,VanY,YSIRK_signal
TLS1_k127_6622499_3	926550.CLDAP_37690	1.133e-20	95.0	COG1898@1|root,COG1898@2|Bacteria,2G7AS@200795|Chloroflexi	200795|Chloroflexi	M	dTDP-4-dehydrorhamnose 3,5-epimerase	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
TLS1_k127_6647880_15	1449347.JQLN01000004_gene6825	1.521e-20	96.0	COG2388@1|root,COG2388@2|Bacteria,2GQNP@201174|Actinobacteria,2M3V4@2063|Kitasatospora	201174|Actinobacteria	S	GCN5-related N-acetyl-transferase	-	-	-	ko:K06975	-	-	-	-	ko00000	-	-	-	Acetyltransf_CG
TLS1_k127_6647880_11	1521187.JPIM01000033_gene2020	4.785e-29	134.0	COG0823@1|root,COG0823@2|Bacteria,2G8T8@200795|Chloroflexi,377EP@32061|Chloroflexia	32061|Chloroflexia	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
TLS1_k127_6647880_2	706587.Desti_4719	2.055e-130	424.0	COG0003@1|root,COG0003@2|Bacteria,1MUTX@1224|Proteobacteria,42V9Y@68525|delta/epsilon subdivisions,2WND5@28221|Deltaproteobacteria,2MS8W@213462|Syntrophobacterales	28221|Deltaproteobacteria	D	Anion-transporting ATPase	arsA	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
TLS1_k127_6647880_1	706587.Desti_4720	5.182e-138	446.0	COG0003@1|root,COG0003@2|Bacteria,1MUTX@1224|Proteobacteria,42V9Y@68525|delta/epsilon subdivisions,2WND5@28221|Deltaproteobacteria,2MS8W@213462|Syntrophobacterales	28221|Deltaproteobacteria	D	Anion-transporting ATPase	arsA	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
TLS1_k127_6647880_10	706587.Desti_4721	1.363e-35	138.0	2DZFA@1|root,32V98@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_6647880_13	706587.Desti_4721	1.134e-22	106.0	2DZFA@1|root,32V98@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_6647880_18	867903.ThesuDRAFT_00602	1.89e-10	70.0	2EMGM@1|root,33F5A@2|Bacteria,1W2YC@1239|Firmicutes,256C3@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_6647880_4	706587.Desti_4722	1.213e-113	389.0	COG1966@1|root,COG1966@2|Bacteria,1MWF9@1224|Proteobacteria,42NBI@68525|delta/epsilon subdivisions,2WM33@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	carbon starvation protein CstA	cstA	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
TLS1_k127_6647880_16	471856.Jden_2198	8.401e-16	91.0	COG0671@1|root,COG0671@2|Bacteria,2HIXE@201174|Actinobacteria	201174|Actinobacteria	I	PFAM phosphoesterase, PA-phosphatase related	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
TLS1_k127_6647880_7	1385935.N836_14195	1.62e-52	201.0	COG0697@1|root,COG0697@2|Bacteria,1G44U@1117|Cyanobacteria,1HEQG@1150|Oscillatoriales	1117|Cyanobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS1_k127_6647880_14	1161401.ASJA01000027_gene48	1.855e-21	95.0	COG3360@1|root,COG3360@2|Bacteria,1PURU@1224|Proteobacteria,2V0YI@28211|Alphaproteobacteria,43YVT@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Dodecin	-	-	-	-	-	-	-	-	-	-	-	-	Dodecin
TLS1_k127_6647880_0	469383.Cwoe_2120	2.88e-143	470.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,4CPJR@84995|Rubrobacteria	84995|Rubrobacteria	J	Belongs to the amidase family	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
TLS1_k127_6647880_3	1380370.JIBA01000006_gene3391	2.116e-124	410.0	COG0436@1|root,COG0436@2|Bacteria,2GPM3@201174|Actinobacteria,4FFXA@85021|Intrasporangiaceae	201174|Actinobacteria	E	Aminotransferase class I and II	-	-	2.6.1.1	ko:K11358	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS1_k127_6647880_6	1298863.AUEP01000004_gene2068	1.417e-57	205.0	2BARS@1|root,3246W@2|Bacteria,2IM0H@201174|Actinobacteria,4DR33@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_6647880_5	552811.Dehly_0574	2.723e-98	336.0	COG0206@1|root,COG0206@2|Bacteria,2G5V2@200795|Chloroflexi,34D9X@301297|Dehalococcoidia	200795|Chloroflexi	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
TLS1_k127_6647880_12	926550.CLDAP_05380	9.307e-27	115.0	COG2318@1|root,COG2318@2|Bacteria,2G7AU@200795|Chloroflexi	200795|Chloroflexi	S	PFAM DinB family protein	-	-	-	-	-	-	-	-	-	-	-	-	DinB
TLS1_k127_6647880_9	383372.Rcas_2468	4.859e-39	152.0	COG0514@1|root,COG1040@1|root,COG0514@2|Bacteria,COG1040@2|Bacteria,2GBUQ@200795|Chloroflexi,376U8@32061|Chloroflexia	32061|Chloroflexia	L	helicase superfamily c-terminal domain	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Helicase_C
TLS1_k127_6659553_6	450380.JPSY01000001_gene928	8.575e-05	52.0	COG1539@1|root,COG1539@2|Bacteria,2IHSW@201174|Actinobacteria,4FPAQ@85023|Microbacteriaceae	201174|Actinobacteria	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folB	GO:0008150,GO:0040007	1.13.11.81,2.7.6.3,4.1.2.25,5.1.99.8	ko:K01633,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00840	R03503,R03504,R11037,R11073	RC00002,RC00017,RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
TLS1_k127_6659553_5	1569209.BBPH01000174_gene3858	2.202e-16	87.0	COG2968@1|root,COG2968@2|Bacteria,1RH7T@1224|Proteobacteria,2U981@28211|Alphaproteobacteria,2PWHI@265|Paracoccus	28211|Alphaproteobacteria	S	Protein of unknown function (DUF541)	omp28	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
TLS1_k127_6659553_1	1382356.JQMP01000003_gene1889	2.842e-80	301.0	COG0744@1|root,COG0744@2|Bacteria,2G5ZG@200795|Chloroflexi,27XN3@189775|Thermomicrobia	189775|Thermomicrobia	M	Transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
TLS1_k127_6659553_4	1219375.CM002139_gene270	9.001e-30	133.0	COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1S79G@1236|Gammaproteobacteria,1XAT2@135614|Xanthomonadales	135614|Xanthomonadales	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS1_k127_6659553_2	1173026.Glo7428_1115	1.008e-58	235.0	COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,1G0A1@1117|Cyanobacteria	1117|Cyanobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,HATPase_c,HisKA,MHYT,PAS,PAS_3,PAS_4,PAS_9
TLS1_k127_6659553_0	479434.Sthe_2401	1.103e-95	356.0	COG0642@1|root,COG2203@1|root,COG3829@1|root,COG5000@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,COG5000@2|Bacteria,2G7SE@200795|Chloroflexi	200795|Chloroflexi	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA
TLS1_k127_6659553_3	319795.Dgeo_0362	1.048e-48	188.0	COG0598@1|root,COG0598@2|Bacteria	2|Bacteria	P	Magnesium transport protein CorA	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
TLS1_k127_666341_4	1128421.JAGA01000003_gene3397	6.269e-47	193.0	COG0842@1|root,COG0842@2|Bacteria,2NQYW@2323|unclassified Bacteria	2|Bacteria	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS1_k127_666341_3	926569.ANT_06950	1.411e-80	281.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS1_k127_666341_0	1128421.JAGA01000003_gene3395	4.301e-102	345.0	COG1131@1|root,COG1131@2|Bacteria,2NP0I@2323|unclassified Bacteria	2|Bacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS1_k127_666341_5	326424.FRAAL0868	2.037e-46	175.0	COG1309@1|root,COG1309@2|Bacteria,2GM45@201174|Actinobacteria	201174|Actinobacteria	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS1_k127_666341_2	1121033.AUCF01000001_gene2076	8.086e-86	296.0	COG2313@1|root,COG2313@2|Bacteria,1MUQU@1224|Proteobacteria,2TUKT@28211|Alphaproteobacteria,2JR4R@204441|Rhodospirillales	204441|Rhodospirillales	Q	Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway	psuG	-	4.2.1.70	ko:K16329	ko00240,map00240	-	R01055	RC00432,RC00433	ko00000,ko00001,ko01000	-	-	-	Indigoidine_A
TLS1_k127_666341_1	28444.JODQ01000007_gene5685	2.104e-91	326.0	COG1506@1|root,COG1506@2|Bacteria,2GMMM@201174|Actinobacteria	201174|Actinobacteria	EU	Peptidase S9 prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
TLS1_k127_6701837_4	1122247.C731_1647	1.069e-57	211.0	COG2025@1|root,COG2025@2|Bacteria,2GJWH@201174|Actinobacteria,233G5@1762|Mycobacteriaceae	201174|Actinobacteria	C	Electron transfer flavoprotein	etfA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
TLS1_k127_6701837_6	1123354.AUDR01000014_gene957	1.281e-39	160.0	COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,2VR9P@28216|Betaproteobacteria,1KSP2@119069|Hydrogenophilales	119069|Hydrogenophilales	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
TLS1_k127_6701837_1	590998.Celf_0318	4.159e-74	261.0	COG0717@1|root,COG0717@2|Bacteria,2GKQQ@201174|Actinobacteria,4F1PA@85016|Cellulomonadaceae	201174|Actinobacteria	F	Belongs to the dCTP deaminase family	dcd	GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0019239,GO:0033973,GO:0047429	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD
TLS1_k127_6701837_8	546414.Deide_10340	3.349e-37	159.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	ytnP	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS1_k127_6701837_11	471853.Bcav_1553	3.859e-15	80.0	COG3795@1|root,COG3795@2|Bacteria,2IMCW@201174|Actinobacteria	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
TLS1_k127_6701837_10	765420.OSCT_0974	1.341e-25	114.0	COG0484@1|root,COG0526@1|root,COG0484@2|Bacteria,COG0526@2|Bacteria,2G737@200795|Chloroflexi,375V3@32061|Chloroflexia	32061|Chloroflexia	CO	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DnaJ
TLS1_k127_6701837_7	644284.Arch_1472	1.632e-37	155.0	COG0785@1|root,COG0785@2|Bacteria,2GJW3@201174|Actinobacteria,4D5GJ@85005|Actinomycetales	201174|Actinobacteria	O	Cytochrome C biogenesis protein transmembrane region	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	AhpC-TSA,DsbD
TLS1_k127_6701837_13	110319.CF8_0420	4.367e-07	57.0	COG0695@1|root,COG0695@2|Bacteria,2IR0P@201174|Actinobacteria,4DS21@85009|Propionibacteriales	201174|Actinobacteria	O	Glutaredoxin-like domain (DUF836)	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF836
TLS1_k127_6701837_5	1246995.AFR_16350	7.193e-41	161.0	COG0491@1|root,COG0491@2|Bacteria,2HGYG@201174|Actinobacteria,4DHF6@85008|Micromonosporales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS1_k127_6701837_14	1380347.JNII01000005_gene2886	0.0001371	56.0	COG4783@1|root,COG4783@2|Bacteria,2IIVV@201174|Actinobacteria,4EV0E@85013|Frankiales	201174|Actinobacteria	S	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_6701837_12	37919.EP51_37010	2.079e-10	64.0	2FFP8@1|root,347KK@2|Bacteria,2GSJ4@201174|Actinobacteria,4G456@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_6701837_2	1121946.AUAX01000023_gene4182	1.118e-72	252.0	COG0596@1|root,COG0596@2|Bacteria,2GJ4I@201174|Actinobacteria,4DM56@85008|Micromonosporales	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS1_k127_6701837_0	1123320.KB889713_gene8085	1.914e-125	408.0	COG2021@1|root,COG2021@2|Bacteria	2|Bacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	-	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
TLS1_k127_6701837_9	1382306.JNIM01000001_gene1358	1.904e-34	145.0	COG0215@1|root,COG1216@1|root,COG0215@2|Bacteria,COG1216@2|Bacteria,2G5Z0@200795|Chloroflexi	2|Bacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
TLS1_k127_6701837_3	1382306.JNIM01000001_gene664	4.546e-59	216.0	COG0215@1|root,COG0215@2|Bacteria,2G5Z0@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	-	-	-	-	-	-	-	-	-	-	tRNA-synt_1e
TLS1_k127_6709266_3	880073.Calab_1754	2.824e-22	111.0	COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,2NQ6Y@2323|unclassified Bacteria	2|Bacteria	M	PKD domain	-	-	3.2.1.4,3.4.21.66	ko:K01179,ko:K08651	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	GH5,GH9	-	Autotransporter,PKD,Peptidase_S8,Peptidase_S8_N,fn3
TLS1_k127_6709266_1	1120954.ATXE01000003_gene585	1.565e-53	205.0	COG0726@1|root,COG4886@1|root,COG5479@1|root,COG0726@2|Bacteria,COG4886@2|Bacteria,COG5479@2|Bacteria,2I6Q0@201174|Actinobacteria,4DX27@85009|Propionibacteriales	201174|Actinobacteria	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	LGFP,Peptidase_M15_4
TLS1_k127_6709266_2	383372.Rcas_3103	9.44e-44	184.0	COG3307@1|root,COG3307@2|Bacteria,2GB55@200795|Chloroflexi,377AJ@32061|Chloroflexia	32061|Chloroflexia	M	PFAM O-antigen polymerase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
TLS1_k127_6709266_0	1452718.JBOY01000038_gene2002	2.973e-65	239.0	COG1215@1|root,COG1215@2|Bacteria,1QUFX@1224|Proteobacteria,1RN4M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG1215 Glycosyltransferases, probably involved in cell wall biogenesis	sypQ	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
TLS1_k127_6721177_3	1382306.JNIM01000001_gene1527	8.744e-88	299.0	COG0642@1|root,COG2205@2|Bacteria,2G601@200795|Chloroflexi	200795|Chloroflexi	T	Osmosensitive K+ channel His kinase sensor domain	-	-	-	-	-	-	-	-	-	-	-	-	KdpD,Usp
TLS1_k127_6721177_9	1382356.JQMP01000003_gene1961	3.857e-15	81.0	COG0745@1|root,COG0745@2|Bacteria,2G9SH@200795|Chloroflexi	200795|Chloroflexi	T	SPTR D1CGX5 Response regulator receiver protein	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS1_k127_6721177_7	1382356.JQMP01000003_gene1960	2.701e-55	215.0	COG0745@1|root,COG0745@2|Bacteria,2G5ND@200795|Chloroflexi,27YDQ@189775|Thermomicrobia	189775|Thermomicrobia	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS1_k127_6721177_5	1382356.JQMP01000003_gene1959	4.281e-72	263.0	COG0642@1|root,COG2205@2|Bacteria,2GAAW@200795|Chloroflexi,27Z8B@189775|Thermomicrobia	189775|Thermomicrobia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TLS1_k127_6721177_8	1198114.AciX9_2726	1.588e-36	147.0	2CP0Z@1|root,32SI8@2|Bacteria,3Y4TI@57723|Acidobacteria,2JJK0@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF3037)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3037
TLS1_k127_6721177_4	290397.Adeh_2156	7.502e-83	299.0	COG1718@1|root,COG1718@2|Bacteria,1N7US@1224|Proteobacteria,43BB3@68525|delta/epsilon subdivisions,2X6Q8@28221|Deltaproteobacteria,2YTY8@29|Myxococcales	28221|Deltaproteobacteria	DT	Serine threonine protein kinase involved in cell cycle control	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_6721177_0	235985.BBPN01000035_gene746	8.422e-202	638.0	COG1819@1|root,COG1819@2|Bacteria,2GJN7@201174|Actinobacteria,2NK5V@228398|Streptacidiphilus	201174|Actinobacteria	CG	UDP-glucoronosyl and UDP-glucosyl transferase	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0009058,GO:0009247,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0020012,GO:0030682,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044464,GO:0046467,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071704,GO:0071944,GO:0075136,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C,UDPGT
TLS1_k127_6721177_6	2002.JOEQ01000004_gene2634	1.333e-67	246.0	COG3281@1|root,COG3281@2|Bacteria,2IBUS@201174|Actinobacteria,4EIG4@85012|Streptosporangiales	201174|Actinobacteria	G	Aminoglycoside phosphotransferase	-	-	2.7.1.175	ko:K16146	ko00500,ko01100,map00500,map01100	-	R09945	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	-
TLS1_k127_6721177_2	479432.Sros_1799	1.421e-112	383.0	COG2222@1|root,COG2222@2|Bacteria,2IBP7@201174|Actinobacteria,4EIEZ@85012|Streptosporangiales	201174|Actinobacteria	M	sugar isomerase	-	-	-	-	-	-	-	-	-	-	-	-	SIS
TLS1_k127_6721177_1	526225.Gobs_2523	4.45e-119	397.0	COG0596@1|root,COG0596@2|Bacteria,2GMYM@201174|Actinobacteria,4EUGJ@85013|Frankiales	201174|Actinobacteria	S	Alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
TLS1_k127_6736535_0	309801.trd_0084	5.378e-152	505.0	COG1200@1|root,COG1200@2|Bacteria,2G5YM@200795|Chloroflexi,27XT4@189775|Thermomicrobia	189775|Thermomicrobia	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
TLS1_k127_6736535_5	240015.ACP_2906	1.46e-30	128.0	COG0742@1|root,COG0742@2|Bacteria,3Y4K0@57723|Acidobacteria,2JJDW@204432|Acidobacteriia	204432|Acidobacteriia	L	Conserved hypothetical protein 95	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth95
TLS1_k127_6736535_4	1242864.D187_007204	1.004e-45	179.0	COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,42RJQ@68525|delta/epsilon subdivisions,2WNDS@28221|Deltaproteobacteria,2YYUB@29|Myxococcales	28221|Deltaproteobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
TLS1_k127_6736535_10	1140.Synpcc7942_2006	2.168e-10	69.0	COG1193@1|root,COG1193@2|Bacteria,1G5WM@1117|Cyanobacteria,1H4BY@1129|Synechococcus	1117|Cyanobacteria	L	negative regulation of DNA recombination	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_6736535_7	1382306.JNIM01000001_gene3739	2.103e-25	122.0	COG1399@1|root,COG1399@2|Bacteria,2G6Z5@200795|Chloroflexi	200795|Chloroflexi	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
TLS1_k127_6736535_8	867903.ThesuDRAFT_00311	1.835e-16	80.0	COG0333@1|root,COG0333@2|Bacteria,1VEFI@1239|Firmicutes,24QM0@186801|Clostridia,3WCP9@538999|Clostridiales incertae sedis	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
TLS1_k127_6736535_1	1131462.DCF50_p2162	7.3e-86	303.0	COG0416@1|root,COG0416@2|Bacteria,1TPXS@1239|Firmicutes,247KW@186801|Clostridia,2610G@186807|Peptococcaceae	186801|Clostridia	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
TLS1_k127_6736535_9	552811.Dehly_0304	3.075e-14	84.0	COG0781@1|root,COG0781@2|Bacteria,2G6XA@200795|Chloroflexi,34CUC@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
TLS1_k127_6736535_6	635013.TherJR_2073	1.008e-25	109.0	COG0236@1|root,COG0236@2|Bacteria,1VEE3@1239|Firmicutes,24QME@186801|Clostridia,262SV@186807|Peptococcaceae	186801|Clostridia	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
TLS1_k127_6736535_3	1122919.KB905554_gene860	5.856e-50	190.0	COG0571@1|root,COG0571@2|Bacteria,1TPGC@1239|Firmicutes,4HAWU@91061|Bacilli,26S9I@186822|Paenibacillaceae	91061|Bacilli	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
TLS1_k127_6736535_2	1382306.JNIM01000001_gene1910	8.342e-59	233.0	COG1196@1|root,COG1196@2|Bacteria,2G64A@200795|Chloroflexi	200795|Chloroflexi	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
TLS1_k127_6747581_11	398767.Glov_3130	1.108e-09	66.0	COG1143@1|root,COG1143@2|Bacteria,1MZJF@1224|Proteobacteria,42M7S@68525|delta/epsilon subdivisions,2WQKZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI-1	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_7
TLS1_k127_6747581_9	644283.Micau_5562	2.543e-17	91.0	COG0839@1|root,COG0839@2|Bacteria,2GJB7@201174|Actinobacteria,4DDEB@85008|Micromonosporales	201174|Actinobacteria	C	Belongs to the complex I subunit 6 family	nuoJ2	-	1.6.5.3	ko:K00339,ko:K05578	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
TLS1_k127_6747581_7	1089548.KI783301_gene3079	6.96e-19	93.0	COG0713@1|root,COG0713@2|Bacteria,1V9Z8@1239|Firmicutes,4HJ9Q@91061|Bacilli	91061|Bacilli	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
TLS1_k127_6747581_0	479434.Sthe_0299	2.127e-179	583.0	COG1009@1|root,COG1009@2|Bacteria,2G5NJ@200795|Chloroflexi,27XR2@189775|Thermomicrobia	189775|Thermomicrobia	C	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
TLS1_k127_6747581_1	237368.SCABRO_01998	5.257e-135	460.0	COG1008@1|root,COG1008@2|Bacteria,2IX79@203682|Planctomycetes	203682|Planctomycetes	C	proton-translocating NADH-quinone oxidoreductase, chain M	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
TLS1_k127_6747581_2	243231.GSU0351	1.087e-96	352.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42P7Z@68525|delta/epsilon subdivisions,2WK06@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TLS1_k127_6747581_8	1123517.JOMR01000001_gene491	2.302e-17	92.0	COG0526@1|root,COG0526@2|Bacteria,1QTY9@1224|Proteobacteria,1T2D3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
TLS1_k127_6747581_12	350688.Clos_1802	0.0007687	49.0	2DT9A@1|root,33JA8@2|Bacteria,1VKQX@1239|Firmicutes,25P4B@186801|Clostridia,36TVS@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_6747581_5	309803.CTN_0106	4.845e-47	184.0	COG0598@1|root,COG0598@2|Bacteria,2GCUD@200918|Thermotogae	200918|Thermotogae	P	Mediates influx of magnesium ions	corA	GO:0000041,GO:0000287,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015087,GO:0015095,GO:0015318,GO:0015693,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0050897,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0070838,GO:0071840,GO:0071944,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:1903830	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
TLS1_k127_6747581_4	479434.Sthe_1684	3.582e-54	212.0	COG0477@1|root,COG2814@2|Bacteria,2G7PR@200795|Chloroflexi	200795|Chloroflexi	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS1_k127_6747581_10	485913.Krac_8941	3.039e-13	74.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	DUF2087,HTH_20,HTH_5
TLS1_k127_6747581_6	255470.cbdbA940	1.449e-20	103.0	COG0558@1|root,COG0558@2|Bacteria,2G6ZT@200795|Chloroflexi,34D5W@301297|Dehalococcoidia	301297|Dehalococcoidia	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS1_k127_6747581_3	552811.Dehly_0526	1.524e-65	229.0	COG1260@1|root,COG1260@2|Bacteria,2G5YH@200795|Chloroflexi,34CJX@301297|Dehalococcoidia	301297|Dehalococcoidia	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
TLS1_k127_6755905_17	443906.CMM_0827	6.075e-10	69.0	COG0489@1|root,COG3944@1|root,COG0489@2|Bacteria,COG3944@2|Bacteria,2GJ1Y@201174|Actinobacteria,4FNA7@85023|Microbacteriaceae	201174|Actinobacteria	D	Chain length determinant protein	wcoI	-	-	-	-	-	-	-	-	-	-	-	AAA_31,GNVR,ParA,Wzz
TLS1_k127_6755905_13	596152.DesU5LDRAFT_2520	6.347e-28	128.0	COG0726@1|root,COG0726@2|Bacteria,1MVKH@1224|Proteobacteria,42UKB@68525|delta/epsilon subdivisions,2WQD0@28221|Deltaproteobacteria,2MDAN@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
TLS1_k127_6755905_2	338966.Ppro_2168	5.325e-109	379.0	COG3919@1|root,COG3919@2|Bacteria,1N13P@1224|Proteobacteria,42WGT@68525|delta/epsilon subdivisions,2WRKR@28221|Deltaproteobacteria,43VRY@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3
TLS1_k127_6755905_7	1463936.JOJI01000031_gene2199	1.092e-67	242.0	COG2513@1|root,COG2513@2|Bacteria,2GJZZ@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate	-	-	5.4.2.9	ko:K01841	ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130	-	R00661	RC02792	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
TLS1_k127_6755905_4	338963.Pcar_0629	9.93e-100	335.0	COG1052@1|root,COG1052@2|Bacteria,1REXX@1224|Proteobacteria,42R07@68525|delta/epsilon subdivisions,2X7JR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.310,1.1.1.399,1.1.1.95	ko:K00058,ko:K16843	ko00260,ko00270,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513,R05693	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
TLS1_k127_6755905_15	1380390.JIAT01000010_gene4359	2.815e-19	99.0	COG0125@1|root,COG0125@2|Bacteria,2H78H@201174|Actinobacteria	201174|Actinobacteria	F	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_6755905_12	526225.Gobs_0361	1.141e-43	174.0	2C1GN@1|root,33V5B@2|Bacteria,2H4C5@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_6755905_10	1380390.JIAT01000010_gene4360	1.663e-64	241.0	COG2244@1|root,COG2244@2|Bacteria,2I4II@201174|Actinobacteria,4CTZ7@84995|Rubrobacteria	84995|Rubrobacteria	S	Polysaccharide biosynthesis C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
TLS1_k127_6755905_18	861360.AARI_19970	0.0007723	53.0	COG0510@1|root,COG0510@2|Bacteria,2I95C@201174|Actinobacteria	201174|Actinobacteria	M	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS1_k127_6755905_9	1121028.ARQE01000008_gene2310	4.063e-65	235.0	COG2390@1|root,COG2390@2|Bacteria,1MX3F@1224|Proteobacteria,2UP5D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Putative sugar-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Sugar-bind
TLS1_k127_6755905_3	1416759.AYMR01000009_gene2922	1.294e-101	353.0	COG0191@1|root,COG0191@2|Bacteria,2H640@201174|Actinobacteria,4FR8M@85023|Microbacteriaceae	201174|Actinobacteria	G	Fructose-bisphosphate aldolase class-II	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
TLS1_k127_6755905_5	1380390.JIAT01000009_gene1631	4.375e-97	336.0	COG0637@1|root,COG0637@2|Bacteria,2GMIQ@201174|Actinobacteria,4CQKP@84995|Rubrobacteria	84995|Rubrobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
TLS1_k127_6755905_8	1246995.AFR_23230	2.332e-66	233.0	COG1461@1|root,COG1461@2|Bacteria,2IH72@201174|Actinobacteria	201174|Actinobacteria	S	Dak2	-	-	2.7.1.121	ko:K05879	ko00561,ko01100,map00561,map01100	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000	-	-	-	Dak2
TLS1_k127_6755905_0	1454010.JEOE01000014_gene1418	1.291e-152	488.0	COG2376@1|root,COG2376@2|Bacteria,2GJV9@201174|Actinobacteria,4F0V3@85016|Cellulomonadaceae	201174|Actinobacteria	G	PFAM Dak kinase	dhaK2	-	2.7.1.121	ko:K05878	ko00561,ko01100,map00561,map01100	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000	-	-	-	Dak1
TLS1_k127_6755905_14	583355.Caka_0540	3.838e-27	129.0	COG5434@1|root,COG5434@2|Bacteria	2|Bacteria	M	polygalacturonase activity	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Alginate_lyase,CBM_35,CBM_6,F5_F8_type_C,Glyco_hydro_30,Glyco_hydro_30C,Glyco_hydro_76,Melibiase_2
TLS1_k127_6755905_11	1380390.JIAT01000010_gene4370	3.945e-47	192.0	COG1409@1|root,COG1409@2|Bacteria,2GVVJ@201174|Actinobacteria	201174|Actinobacteria	S	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	-	-	-	-	-	-	-	-	-	-	-	-	Big_5
TLS1_k127_6755905_6	1121374.KB891587_gene3078	1.142e-89	313.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,1RMVW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	ugd	GO:0000271,GO:0003674,GO:0003824,GO:0003979,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046377,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901576	1.1.1.132,1.1.1.22	ko:K00012,ko:K00066	ko00040,ko00051,ko00053,ko00520,ko01100,ko02020,map00040,map00051,map00053,map00520,map01100,map02020	M00014,M00129,M00361,M00362	R00286,R00880	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	iEC55989_1330.EC55989_2287	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
TLS1_k127_6755905_1	1158050.KB895461_gene2922	1.474e-123	421.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_5,CBM_4_9
TLS1_k127_6755905_16	356851.JOAN01000029_gene4992	7.58e-19	102.0	COG1409@1|root,COG1409@2|Bacteria,2GIT1@201174|Actinobacteria,4DM0J@85008|Micromonosporales	201174|Actinobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
TLS1_k127_6856958_2	926550.CLDAP_22250	6.085e-07	55.0	COG2198@1|root,COG2198@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	ko:K20976	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Hpt,Response_reg
TLS1_k127_6856958_1	981384.AEYW01000001_gene1562	5.144e-179	612.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TX3Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,Response_reg,dCache_1
TLS1_k127_6856958_0	309801.trd_A0430	1.835e-180	576.0	COG0174@1|root,COG0174@2|Bacteria,2G5U2@200795|Chloroflexi,27XSZ@189775|Thermomicrobia	2|Bacteria	E	glutamine synthetase	glnA2	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
TLS1_k127_692698_0	1123321.KB905832_gene334	3.399e-82	288.0	COG4552@1|root,COG4552@2|Bacteria,2GNXZ@201174|Actinobacteria	201174|Actinobacteria	S	N-acetyltransferase	eis	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
TLS1_k127_692698_3	479433.Caci_2525	1.795e-15	82.0	COG3794@1|root,COG3794@2|Bacteria,2IQAI@201174|Actinobacteria	201174|Actinobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
TLS1_k127_692698_1	1380347.JNII01000008_gene4355	8.869e-51	189.0	COG2345@1|root,COG2345@2|Bacteria,2HCEF@201174|Actinobacteria,4ESVJ@85013|Frankiales	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS1_k127_692698_2	1123024.AUII01000004_gene1588	1.348e-31	125.0	COG3214@1|root,COG3214@2|Bacteria,2GK0T@201174|Actinobacteria,4DXN1@85010|Pseudonocardiales	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
TLS1_k127_6993747_2	1254432.SCE1572_31205	3.26e-153	499.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,42MYA@68525|delta/epsilon subdivisions,2WKFB@28221|Deltaproteobacteria,2YUKP@29|Myxococcales	28221|Deltaproteobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
TLS1_k127_6993747_7	926550.CLDAP_19560	3.043e-23	106.0	2EB0S@1|root,3351M@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_6993747_10	479435.Kfla_1234	1.038e-14	78.0	COG5516@1|root,COG5516@2|Bacteria,2GRF7@201174|Actinobacteria,4DSEU@85009|Propionibacteriales	201174|Actinobacteria	S	Putative stress-induced transcription regulator	-	-	-	-	-	-	-	-	-	-	-	-	ABATE,zf-CGNR
TLS1_k127_6993747_9	326427.Cagg_3353	3.222e-16	86.0	2AKD7@1|root,31B4D@2|Bacteria,2GBQM@200795|Chloroflexi,3762Y@32061|Chloroflexia	32061|Chloroflexia	S	Predicted integral membrane protein (DUF2269)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2269
TLS1_k127_6993747_0	285514.JNWO01000026_gene2481	2.465e-168	543.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.8	ko:K00130	ko00260,ko01100,map00260,map01100	M00555	R02565,R02566	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS1_k127_6993747_8	296591.Bpro_3706	5.554e-19	94.0	COG2329@1|root,COG2329@2|Bacteria,1QTY7@1224|Proteobacteria,2WGHG@28216|Betaproteobacteria,4AJJR@80864|Comamonadaceae	28216|Betaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
TLS1_k127_6993747_14	1122933.JNIY01000011_gene1218	0.0008417	51.0	2CD8B@1|root,30VJG@2|Bacteria,2GY49@201174|Actinobacteria,4F310@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_6993747_11	1313172.YM304_27110	4.645e-11	68.0	COG3743@1|root,COG3743@2|Bacteria	2|Bacteria	S	rRNA binding	MA20_15755	-	-	-	-	-	-	-	-	-	-	-	DUF4332
TLS1_k127_6993747_12	1176165.CAJD01000019_gene1620	1.371e-09	68.0	COG4478@1|root,COG4478@2|Bacteria,2IFW4@201174|Actinobacteria,4F8AU@85019|Brevibacteriaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1461)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1461
TLS1_k127_6993747_4	525904.Tter_0222	8.942e-51	202.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2NPE1@2323|unclassified Bacteria	2|Bacteria	S	Peptidase family M50	rip3	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K06212,ko:K06402	-	-	-	-	ko00000,ko01000,ko01002,ko02000	1.A.16.1.1,1.A.16.1.3	-	-	CBS,Form_Nir_trans,Peptidase_M50
TLS1_k127_6993747_3	479434.Sthe_1113	5.821e-78	279.0	COG0303@1|root,COG0303@2|Bacteria,2G667@200795|Chloroflexi,27XRV@189775|Thermomicrobia	189775|Thermomicrobia	H	MoeA N-terminal region (domain I and II)	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
TLS1_k127_6993747_5	1247963.JPHU01000013_gene627	1.414e-47	178.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,2U747@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
TLS1_k127_6993747_6	682795.AciX8_4294	3.433e-36	153.0	COG0521@1|root,COG0521@2|Bacteria,3Y504@57723|Acidobacteria,2JJI8@204432|Acidobacteriia	204432|Acidobacteriia	H	Probable molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
TLS1_k127_6993747_1	1051632.TPY_3590	1.422e-158	530.0	COG0247@1|root,COG0479@1|root,COG2181@1|root,COG0247@2|Bacteria,COG0479@2|Bacteria,COG2181@2|Bacteria,1TPG1@1239|Firmicutes,24BBE@186801|Clostridia	186801|Clostridia	C	Fe-S oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
TLS1_k127_7104041_1	479434.Sthe_3486	4.148e-174	565.0	COG4867@1|root,COG4867@2|Bacteria,2G8A6@200795|Chloroflexi,27XPF@189775|Thermomicrobia	189775|Thermomicrobia	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7104041_2	1158345.JNLL01000001_gene1734	1.843e-135	449.0	COG0191@1|root,COG0191@2|Bacteria,2G3VP@200783|Aquificae	200783|Aquificae	G	Fructose-bisphosphate aldolase class-II	-	-	-	-	-	-	-	-	-	-	-	-	F_bP_aldolase
TLS1_k127_7104041_4	1123024.AUII01000016_gene1301	3.445e-121	400.0	COG2227@1|root,COG2227@2|Bacteria,2I3C3@201174|Actinobacteria,4EE7R@85010|Pseudonocardiales	201174|Actinobacteria	H	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS1_k127_7104041_12	1283299.AUKG01000002_gene4309	1.02e-63	232.0	COG0510@1|root,COG0510@2|Bacteria,2IAJ7@201174|Actinobacteria,4CR72@84995|Rubrobacteria	84995|Rubrobacteria	M	Choline/ethanolamine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Choline_kinase
TLS1_k127_7104041_7	479434.Sthe_0453	1.737e-85	296.0	COG1409@1|root,COG1409@2|Bacteria,2G88X@200795|Chloroflexi,27Z25@189775|Thermomicrobia	189775|Thermomicrobia	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
TLS1_k127_7104041_0	479432.Sros_0798	1.478e-289	912.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,2GNCW@201174|Actinobacteria,4EFY3@85012|Streptosporangiales	201174|Actinobacteria	E	FAD dependent oxidoreductase central domain	-	-	1.5.3.19	ko:K19191	ko00760,ko01120,map00760,map01120	-	R10102	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
TLS1_k127_7104041_14	1435356.Y013_07260	7.247e-61	229.0	COG0483@1|root,COG0483@2|Bacteria,2GKZZ@201174|Actinobacteria,4FUZ6@85025|Nocardiaceae	201174|Actinobacteria	G	Inositol monophosphatase family	hisN	GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008934,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016020,GO:0016053,GO:0016137,GO:0016138,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0052745,GO:0052803,GO:0052834,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901657,GO:1901659	3.1.3.15,3.1.3.25	ko:K01092,ko:K05602	ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00340,map00521,map00562,map01100,map01110,map01230,map04070	M00026,M00131	R01185,R01186,R01187,R03013	RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
TLS1_k127_7104041_16	1463881.KL591003_gene5650	5.305e-45	185.0	COG1247@1|root,COG1247@2|Bacteria,2I3CR@201174|Actinobacteria	201174|Actinobacteria	M	GCN5 family acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS1_k127_7104041_10	1380347.JNII01000008_gene4082	5.475e-80	286.0	COG1177@1|root,COG1177@2|Bacteria,2GJ6Q@201174|Actinobacteria,4ESYW@85013|Frankiales	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K11070	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
TLS1_k127_7104041_8	469371.Tbis_1011	5.974e-85	292.0	COG1176@1|root,COG1176@2|Bacteria,2GJ5G@201174|Actinobacteria,4DZ26@85010|Pseudonocardiales	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	potH	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
TLS1_k127_7104041_6	35754.JNYJ01000050_gene7962	1.201e-95	334.0	COG0687@1|root,COG0687@2|Bacteria,2GKVG@201174|Actinobacteria,4D9ZP@85008|Micromonosporales	201174|Actinobacteria	E	Bacterial extracellular solute-binding protein	potD	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_6,SBP_bac_8
TLS1_k127_7104041_3	1408419.JHYG01000010_gene2462	1.116e-127	419.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,2JQQC@204441|Rhodospirillales	204441|Rhodospirillales	E	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
TLS1_k127_7104041_5	404589.Anae109_2130	2.79e-113	379.0	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,42NR0@68525|delta/epsilon subdivisions,2WIPG@28221|Deltaproteobacteria,2YU3H@29|Myxococcales	28221|Deltaproteobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
TLS1_k127_7104041_13	1411123.JQNH01000001_gene3832	3.356e-62	239.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,DZR,Guanylate_cyc,SAM_2,TPR_12
TLS1_k127_7104041_17	309801.trd_0950	1.455e-38	158.0	COG1234@1|root,COG1234@2|Bacteria,2GBGY@200795|Chloroflexi,27YCM@189775|Thermomicrobia	189775|Thermomicrobia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TLS1_k127_7104041_15	1122611.KB904007_gene7842	7.281e-46	176.0	COG0664@1|root,COG0664@2|Bacteria,2GMPN@201174|Actinobacteria,4EG3J@85012|Streptosporangiales	201174|Actinobacteria	T	helix_turn_helix, cAMP Regulatory protein	-	-	-	ko:K01420,ko:K10914,ko:K21561,ko:K21564	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
TLS1_k127_7104041_11	319795.Dgeo_2136	4.871e-71	257.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1WIX8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	TIGRFAM competence damage-inducible protein CinA N-terminal domain	cinA	-	3.5.1.42	ko:K03742	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
TLS1_k127_7104041_9	401526.TcarDRAFT_1724	1.755e-84	301.0	COG0544@1|root,COG0544@2|Bacteria,1TQQ8@1239|Firmicutes,4H1YV@909932|Negativicutes	909932|Negativicutes	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	-	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Rho_N,Trigger_C,Trigger_N
TLS1_k127_7104041_19	891968.Anamo_0749	7.19e-15	88.0	COG0740@1|root,COG0740@2|Bacteria,3T9R6@508458|Synergistetes	508458|Synergistetes	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
TLS1_k127_7109475_4	479434.Sthe_2434	1.181e-09	61.0	COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,2G67J@200795|Chloroflexi,27XXA@189775|Thermomicrobia	189775|Thermomicrobia	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2,5.3.1.9	ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	PGI,TAL_FSA
TLS1_k127_7109475_2	661478.OP10G_4092	3.204e-47	178.0	COG0698@1|root,COG0698@2|Bacteria	2|Bacteria	G	galactose-6-phosphate isomerase activity	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2621	LacAB_rpiB
TLS1_k127_7109475_0	357808.RoseRS_4614	2.125e-253	824.0	COG0021@1|root,COG0021@2|Bacteria,2G63Z@200795|Chloroflexi,37502@32061|Chloroflexia	32061|Chloroflexia	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
TLS1_k127_7109475_1	931276.Cspa_c54230	4.996e-73	262.0	COG3754@1|root,COG3754@2|Bacteria	2|Bacteria	M	Rhamnan synthesis protein F	-	-	-	ko:K07272,ko:K20444	-	-	-	-	ko00000,ko01000,ko01003,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_trans_1_4,Glycos_transf_1,Glycos_transf_2,RgpF
TLS1_k127_7109475_3	1136417.AZWE01000018_gene1034	2.82e-38	158.0	COG0524@1|root,COG0524@2|Bacteria,2GP1C@201174|Actinobacteria,4D954@85008|Micromonosporales	201174|Actinobacteria	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
TLS1_k127_7185726_3	1033806.HTIA_2121	3.676e-05	55.0	COG2730@1|root,arCOG07700@2157|Archaea,arCOG09007@2157|Archaea,2Y2AK@28890|Euryarchaeota,23ZD8@183963|Halobacteria	183963|Halobacteria	G	Cellulase (glycosyl hydrolase family 5)	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase,fn3
TLS1_k127_7185726_1	479434.Sthe_1941	2.654e-58	211.0	COG0745@1|root,COG0745@2|Bacteria,2G8EP@200795|Chloroflexi	200795|Chloroflexi	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS1_k127_7185726_0	1229780.BN381_60027	1.685e-66	235.0	COG1335@1|root,COG1335@2|Bacteria,2IFQW@201174|Actinobacteria,3UWWF@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	Q	Isochorismatase family	pncA	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006766,GO:0006767,GO:0006769,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0071704,GO:0072524,GO:1901360,GO:1901564	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
TLS1_k127_7185726_2	391625.PPSIR1_15265	1.167e-45	168.0	COG0258@1|root,COG0258@2|Bacteria,1QV40@1224|Proteobacteria,43BZM@68525|delta/epsilon subdivisions,2X7AE@28221|Deltaproteobacteria,2YUE3@29|Myxococcales	28221|Deltaproteobacteria	L	Helix-hairpin-helix class 2 (Pol1 family) motifs	-	-	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
TLS1_k127_7205370_0	463191.SSEG_06526	1.683e-35	137.0	2DBX9@1|root,2ZBN9@2|Bacteria,2I98J@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7205370_7	1121129.KB903374_gene542	0.0001088	45.0	2DD50@1|root,2ZGIJ@2|Bacteria,4P8A2@976|Bacteroidetes,2FZIU@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7205370_3	395965.Msil_2276	2.379e-31	130.0	COG3631@1|root,COG3631@2|Bacteria,1RD1I@1224|Proteobacteria,2U7YW@28211|Alphaproteobacteria,3NBPE@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
TLS1_k127_7205370_4	1121033.AUCF01000006_gene4120	1.873e-16	88.0	2E4S1@1|root,32ZKH@2|Bacteria,1N9PR@1224|Proteobacteria,2UFAW@28211|Alphaproteobacteria,2JTZW@204441|Rhodospirillales	204441|Rhodospirillales	S	Putative Actinobacterial Holin-X, holin superfamily III	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_3_6
TLS1_k127_7205370_1	1246459.KB898374_gene3976	3.388e-34	146.0	COG2114@1|root,COG2114@2|Bacteria,1Q8YH@1224|Proteobacteria,2VD35@28211|Alphaproteobacteria,4BA5X@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
TLS1_k127_7205370_5	1380394.JADL01000004_gene6126	2.56e-14	74.0	COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria,2TVZE@28211|Alphaproteobacteria,2JZ3B@204441|Rhodospirillales	204441|Rhodospirillales	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS1_k127_7206695_4	42256.RradSPS_1969	5.818e-32	129.0	COG0782@1|root,COG0782@2|Bacteria,2GNZV@201174|Actinobacteria,4CQG1@84995|Rubrobacteria	84995|Rubrobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
TLS1_k127_7206695_5	926560.KE387023_gene1958	3.297e-28	123.0	2DRNI@1|root,33CD9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7206695_1	326427.Cagg_0340	2.462e-61	220.0	COG2197@1|root,COG2197@2|Bacteria,2G6C5@200795|Chloroflexi,377YJ@32061|Chloroflexia	32061|Chloroflexia	K	Sigma-70, region 4 type 2	-	-	-	ko:K11618	ko02020,map02020	M00481,M00754	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
TLS1_k127_7206695_7	1869.MB27_14195	6.467e-14	77.0	COG2197@1|root,COG2197@2|Bacteria,2IGBY@201174|Actinobacteria	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS1_k127_7206695_3	383372.Rcas_4226	2.001e-40	176.0	COG4585@1|root,COG5000@1|root,COG4585@2|Bacteria,COG5000@2|Bacteria,2G8GW@200795|Chloroflexi,3776B@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase, dimerisation and phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA_3
TLS1_k127_7206695_2	1337936.IJ00_19810	2.553e-50	209.0	COG0642@1|root,COG2202@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1G09B@1117|Cyanobacteria,1HKS3@1161|Nostocales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Pkinase,Response_reg
TLS1_k127_7206695_6	479432.Sros_8514	2.783e-15	93.0	COG2203@1|root,COG2508@1|root,COG2203@2|Bacteria,COG2508@2|Bacteria,2GM1G@201174|Actinobacteria,4EFMS@85012|Streptosporangiales	201174|Actinobacteria	T	PucR C-terminal helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HTH_30
TLS1_k127_7206695_9	1370121.AUWS01000026_gene3117	1.306e-08	70.0	COG2203@1|root,COG2508@1|root,COG2203@2|Bacteria,COG2508@2|Bacteria,2GM1G@201174|Actinobacteria,2353M@1762|Mycobacteriaceae	201174|Actinobacteria	QT	PucR C-terminal helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HTH_30
TLS1_k127_7206695_10	926550.CLDAP_19570	7.232e-07	58.0	2EV6B@1|root,33NM4@2|Bacteria,2G7I5@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7206695_8	368407.Memar_2420	2.228e-11	74.0	COG3794@1|root,arCOG02926@2157|Archaea	2157|Archaea	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7206695_0	675635.Psed_0619	1.462e-74	258.0	COG4152@1|root,COG4152@2|Bacteria,2I2DK@201174|Actinobacteria,4DX3X@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS1_k127_720775_16	1035308.AQYY01000001_gene2788	7.268e-19	96.0	29HWC@1|root,304TF@2|Bacteria,1VJR2@1239|Firmicutes,24S15@186801|Clostridia,2658U@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
TLS1_k127_720775_10	930171.Asphe3_23090	5.503e-44	178.0	2F80W@1|root,340EF@2|Bacteria,2H76Z@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_720775_12	1429046.RR21198_5029	7.266e-33	132.0	COG0748@1|root,COG0748@2|Bacteria	2|Bacteria	P	coenzyme F420 binding	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
TLS1_k127_720775_0	1122939.ATUD01000006_gene1755	2.826e-164	529.0	COG0438@1|root,COG0438@2|Bacteria,2GR58@201174|Actinobacteria,4CPE6@84995|Rubrobacteria	84995|Rubrobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS1_k127_720775_19	331869.BAL199_03199	8.05e-14	81.0	COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,2TSDP@28211|Alphaproteobacteria,4BPQJ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	PFAM FAD binding domain of DNA photolyase	phrB	GO:0000003,GO:0000166,GO:0000719,GO:0001101,GO:0002252,GO:0002376,GO:0003006,GO:0003674,GO:0003824,GO:0003904,GO:0003913,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005773,GO:0006139,GO:0006259,GO:0006281,GO:0006290,GO:0006325,GO:0006338,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006874,GO:0006875,GO:0006950,GO:0006952,GO:0006974,GO:0006996,GO:0007154,GO:0007165,GO:0007275,GO:0007623,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009314,GO:0009414,GO:0009415,GO:0009416,GO:0009605,GO:0009606,GO:0009607,GO:0009615,GO:0009628,GO:0009637,GO:0009638,GO:0009642,GO:0009645,GO:0009646,GO:0009648,GO:0009719,GO:0009725,GO:0009785,GO:0009791,GO:0009881,GO:0009882,GO:0009888,GO:0009893,GO:0009909,GO:0009911,GO:0009987,GO:0010033,GO:0010035,GO:0010073,GO:0010075,GO:0010118,GO:0010228,GO:0010244,GO:0010617,GO:0014070,GO:0016043,GO:0016604,GO:0016829,GO:0016830,GO:0017076,GO:0019222,GO:0019637,GO:0019725,GO:0022414,GO:0022603,GO:0023052,GO:0030003,GO:0030522,GO:0030554,GO:0031323,GO:0031325,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0033993,GO:0034641,GO:0035639,GO:0036094,GO:0038023,GO:0040008,GO:0042221,GO:0042592,GO:0042726,GO:0042752,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044260,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0048037,GO:0048507,GO:0048509,GO:0048511,GO:0048518,GO:0048522,GO:0048571,GO:0048573,GO:0048574,GO:0048580,GO:0048582,GO:0048583,GO:0048608,GO:0048638,GO:0048731,GO:0048831,GO:0048856,GO:0048878,GO:0050660,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0050801,GO:0050896,GO:0051094,GO:0051186,GO:0051239,GO:0051240,GO:0051276,GO:0051480,GO:0051607,GO:0051704,GO:0051707,GO:0051716,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055086,GO:0060089,GO:0061458,GO:0065007,GO:0065008,GO:0070013,GO:0071214,GO:0071478,GO:0071482,GO:0071483,GO:0071704,GO:0071840,GO:0071949,GO:0072387,GO:0072503,GO:0072507,GO:0090304,GO:0097159,GO:0097367,GO:0098542,GO:0098771,GO:0104004,GO:0140097,GO:1900618,GO:1901265,GO:1901360,GO:1901363,GO:1901371,GO:1901564,GO:1901700,GO:1902347,GO:1905421,GO:2000024,GO:2000026,GO:2000028,GO:2000241,GO:2000243,GO:2000377,GO:2000379	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
TLS1_k127_720775_5	1500257.JQNM01000019_gene2757	4.005e-76	269.0	COG2114@1|root,COG2114@2|Bacteria,1ND4Q@1224|Proteobacteria,2U51W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Protein of unknown function (DUF2652)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2652,Polyketide_cyc2
TLS1_k127_720775_13	105420.BBPO01000015_gene5102	7.154e-24	110.0	COG0346@1|root,COG0346@2|Bacteria,2HP3K@201174|Actinobacteria,2NMRU@228398|Streptacidiphilus	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS1_k127_720775_17	398578.Daci_0478	2.267e-15	82.0	COG0789@1|root,COG0789@2|Bacteria,1MZ3P@1224|Proteobacteria,2VUJS@28216|Betaproteobacteria,4AE22@80864|Comamonadaceae	28216|Betaproteobacteria	K	Cd(II) Pb(II)-responsive transcriptional regulator	cadR	-	-	-	-	-	-	-	-	-	-	-	MerR,MerR-DNA-bind,MerR_1
TLS1_k127_720775_3	67352.JODS01000022_gene3686	1.03e-86	304.0	COG2304@1|root,COG2304@2|Bacteria,2GJRP@201174|Actinobacteria	201174|Actinobacteria	S	tyrosinase	melC2	-	1.14.18.1	ko:K00505	ko00350,ko00950,ko00965,ko01100,ko01110,ko04916,map00350,map00950,map00965,map01100,map01110,map04916	M00042	R00731,R02078,R02363,R02383,R04693,R04884	RC00046,RC00150,RC00180	ko00000,ko00001,ko00002,ko01000	-	-	-	Tyrosinase
TLS1_k127_720775_4	590998.Celf_3186	1.284e-86	298.0	COG0189@1|root,COG0189@2|Bacteria,2I8TP@201174|Actinobacteria	201174|Actinobacteria	HJ	COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	RimK
TLS1_k127_720775_9	1248760.ANFZ01000002_gene3206	2.397e-49	183.0	COG0346@1|root,COG0346@2|Bacteria,1N08M@1224|Proteobacteria,2UCUW@28211|Alphaproteobacteria,2K581@204457|Sphingomonadales	204457|Sphingomonadales	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS1_k127_720775_15	1210908.HSB1_12720	1.251e-21	105.0	arCOG00516@1|root,arCOG00516@2157|Archaea,2XXT7@28890|Euryarchaeota,23WEB@183963|Halobacteria	183963|Halobacteria	S	flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS1_k127_720775_14	345341.KUTG_01662	5.197e-23	111.0	COG3576@1|root,COG3576@2|Bacteria,2II3S@201174|Actinobacteria,4EDXA@85010|Pseudonocardiales	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS1_k127_720775_18	103733.JNYO01000068_gene4760	7.243e-15	84.0	COG5516@1|root,COG5516@2|Bacteria,2ID3R@201174|Actinobacteria,4EB33@85010|Pseudonocardiales	201174|Actinobacteria	S	Putative stress-induced transcription regulator	-	-	-	-	-	-	-	-	-	-	-	-	ABATE,zf-CGNR
TLS1_k127_720775_20	262724.TT_C1979	1.049e-12	78.0	COG2105@1|root,COG2105@2|Bacteria,1WKJZ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Gamma-glutamyl cyclotransferase, AIG2-like	-	-	-	-	-	-	-	-	-	-	-	-	GGACT
TLS1_k127_720775_8	1120949.KB903294_gene4319	2.811e-56	201.0	COG3832@1|root,COG3832@2|Bacteria,2GQIZ@201174|Actinobacteria	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS1_k127_720775_11	1120949.KB903294_gene4318	2.635e-39	154.0	COG0640@1|root,COG0640@2|Bacteria,2ISNZ@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
TLS1_k127_720775_6	1121272.KB903261_gene6431	1.763e-65	226.0	2AKGE@1|root,31B89@2|Bacteria,2IN2E@201174|Actinobacteria,4DJQE@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_720775_2	1382306.JNIM01000001_gene2829	7.96e-91	312.0	COG3367@1|root,COG3367@2|Bacteria	2|Bacteria	M	COGs COG3367 conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF1611,DUF1611_N,Peptidase_S8
TLS1_k127_720775_7	378806.STAUR_0696	2.165e-64	237.0	COG4948@1|root,COG4948@2|Bacteria,1MW76@1224|Proteobacteria,42Q93@68525|delta/epsilon subdivisions,2WKAA@28221|Deltaproteobacteria,2YYHJ@29|Myxococcales	28221|Deltaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	5.1.1.20	ko:K19802	-	-	R10938	RC03309	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS1_k127_720775_1	1121920.AUAU01000005_gene961	1.8e-93	318.0	COG0477@1|root,COG2814@2|Bacteria,3Y711@57723|Acidobacteria	57723|Acidobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS1_k127_7212262_22	1386969.AWTB01000093_gene4276	4.445e-57	211.0	COG0524@1|root,COG0524@2|Bacteria,2I04R@201174|Actinobacteria,4GDXH@85026|Gordoniaceae	201174|Actinobacteria	H	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
TLS1_k127_7212262_13	479434.Sthe_0993	1.549e-76	268.0	COG1028@1|root,COG1028@2|Bacteria,2G8P1@200795|Chloroflexi,27XUC@189775|Thermomicrobia	189775|Thermomicrobia	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS1_k127_7212262_51	311424.DhcVS_1500	8.905e-10	65.0	2DPPC@1|root,332VC@2|Bacteria,2GAXR@200795|Chloroflexi,34DJ8@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N
TLS1_k127_7212262_16	255470.cbdbA1715	1.777e-72	257.0	COG1131@1|root,COG1131@2|Bacteria,2G5PC@200795|Chloroflexi,34CZ8@301297|Dehalococcoidia	301297|Dehalococcoidia	V	Domain of unknown function (DUF4162)	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS1_k127_7212262_41	509191.AEDB02000002_gene1187	6.973e-24	117.0	COG1277@1|root,COG1277@2|Bacteria,1UYUR@1239|Firmicutes,24HPX@186801|Clostridia,3WJMT@541000|Ruminococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
TLS1_k127_7212262_2	562970.Btus_0349	7.671e-117	392.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4HABI@91061|Bacilli,279GP@186823|Alicyclobacillaceae	91061|Bacilli	C	CoA-transferase family III	-	-	2.8.3.19	ko:K18702	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
TLS1_k127_7212262_38	1122247.C731_0066	1.736e-24	108.0	COG0748@1|root,COG0748@2|Bacteria,2IIRE@201174|Actinobacteria,238WY@1762|Mycobacteriaceae	201174|Actinobacteria	P	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
TLS1_k127_7212262_12	1128421.JAGA01000002_gene35	3.991e-77	268.0	COG2120@1|root,COG2120@2|Bacteria	2|Bacteria	S	N-acetylglucosaminylinositol deacetylase activity	-	-	3.5.1.115	ko:K18455	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
TLS1_k127_7212262_25	485913.Krac_10317	3.691e-53	200.0	COG2141@1|root,COG2141@2|Bacteria,2G873@200795|Chloroflexi	200795|Chloroflexi	C	COGs COG2141 Coenzyme F420-dependent N5 N10-methylene tetrahydromethanopterin reductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS1_k127_7212262_5	556261.HMPREF0240_01113	6.419e-102	353.0	COG0371@1|root,COG0371@2|Bacteria,1V994@1239|Firmicutes	1239|Firmicutes	C	Iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH_2
TLS1_k127_7212262_18	1385520.N802_05580	5.169e-65	235.0	COG0449@1|root,COG0449@2|Bacteria,2GP4W@201174|Actinobacteria,4FGAB@85021|Intrasporangiaceae	201174|Actinobacteria	M	SIS domain	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	SIS
TLS1_k127_7212262_1	926550.CLDAP_27320	6.4e-141	463.0	COG1129@1|root,COG1129@2|Bacteria,2G649@200795|Chloroflexi	200795|Chloroflexi	P	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10441,ko:K10545,ko:K10548	ko02010,map02010	M00212,M00215,M00216	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.4,3.A.1.2.5	-	-	ABC_tran
TLS1_k127_7212262_20	556261.HMPREF0240_03424	3.881e-60	222.0	COG1879@1|root,COG1879@2|Bacteria,1TQ1B@1239|Firmicutes,247K8@186801|Clostridia,36DBX@31979|Clostridiaceae	186801|Clostridia	G	PFAM periplasmic binding protein	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
TLS1_k127_7212262_8	266835.14021871	2.705e-88	304.0	COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,2U0D6@28211|Alphaproteobacteria,43QWC@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057,ko:K10440,ko:K17209	ko02010,map02010	M00212,M00221,M00592	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.21	-	-	BPD_transp_2
TLS1_k127_7212262_3	1267535.KB906767_gene3326	2.419e-106	350.0	COG1028@1|root,COG1028@2|Bacteria	1267535.KB906767_gene3326|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7212262_27	1385512.N784_11880	7.472e-50	192.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
TLS1_k127_7212262_15	42256.RradSPS_2370	1.042e-73	270.0	COG2843@1|root,COG2843@2|Bacteria,2GK15@201174|Actinobacteria,4CTMV@84995|Rubrobacteria	84995|Rubrobacteria	M	Capsule synthesis protein, CapA	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
TLS1_k127_7212262_6	1121405.dsmv_0645	3.559e-98	337.0	COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,42MZS@68525|delta/epsilon subdivisions,2WIQP@28221|Deltaproteobacteria,2MHR8@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Beta-eliminating lyase	ltaA	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
TLS1_k127_7212262_14	457570.Nther_2188	6.483e-75	281.0	COG4805@1|root,COG4805@2|Bacteria	2|Bacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
TLS1_k127_7212262_35	326427.Cagg_3587	4.973e-30	132.0	COG0106@1|root,COG0106@2|Bacteria,2G6EC@200795|Chloroflexi,376JE@32061|Chloroflexia	32061|Chloroflexia	E	TIGRFAM phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TLS1_k127_7212262_34	1128421.JAGA01000001_gene2135	1.514e-34	142.0	COG0652@1|root,COG0652@2|Bacteria,2NPSW@2323|unclassified Bacteria	2|Bacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0031224,GO:0031226,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.11.1,5.2.1.8	ko:K01802,ko:K03767,ko:K03768,ko:K12132	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03110,ko04147	-	-	-	Pro_isomerase
TLS1_k127_7212262_31	1128421.JAGA01000001_gene2135	1.694e-46	177.0	COG0652@1|root,COG0652@2|Bacteria,2NPSW@2323|unclassified Bacteria	2|Bacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0031224,GO:0031226,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.11.1,5.2.1.8	ko:K01802,ko:K03767,ko:K03768,ko:K12132	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03110,ko04147	-	-	-	Pro_isomerase
TLS1_k127_7212262_37	882083.SacmaDRAFT_2314	1.639e-27	127.0	2C2H7@1|root,32Z8Q@2|Bacteria,2ITDR@201174|Actinobacteria,4E6B1@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
TLS1_k127_7212262_48	324057.Pjdr2_4164	6.735e-11	76.0	COG4409@1|root,COG4409@2|Bacteria,1VTIQ@1239|Firmicutes,4HUHA@91061|Bacilli,26TV7@186822|Paenibacillaceae	91061|Bacilli	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7212262_7	1120960.ATXG01000009_gene60	5.528e-92	308.0	COG0491@1|root,COG0491@2|Bacteria,2H8JM@201174|Actinobacteria,4FNJ0@85023|Microbacteriaceae	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS1_k127_7212262_23	103733.JNYO01000022_gene6965	9.774e-55	198.0	COG1309@1|root,COG1309@2|Bacteria,2IJNE@201174|Actinobacteria,4EEWN@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
TLS1_k127_7212262_10	1280390.CBQR020000149_gene3847	6.679e-82	287.0	COG4152@1|root,COG4152@2|Bacteria,1TR06@1239|Firmicutes,4H9RX@91061|Bacilli,26QV7@186822|Paenibacillaceae	91061|Bacilli	S	ABC transporter, ATP-binding protein	yhaQ	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS1_k127_7212262_32	211114.JOEF01000001_gene7641	1.377e-41	170.0	COG1668@1|root,COG1668@2|Bacteria,2I9MY@201174|Actinobacteria,4DYBQ@85010|Pseudonocardiales	201174|Actinobacteria	CP	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
TLS1_k127_7212262_26	101510.RHA1_ro06736	1.55e-52	190.0	COG4430@1|root,COG4430@2|Bacteria,2IN25@201174|Actinobacteria,4G8JG@85025|Nocardiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF1905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1905,OmdA
TLS1_k127_7212262_4	1242864.D187_006998	1.605e-104	370.0	COG4188@1|root,COG4188@2|Bacteria,1Q4K6@1224|Proteobacteria,42YYD@68525|delta/epsilon subdivisions,2WTU7@28221|Deltaproteobacteria,2Z2HI@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase family 6	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7212262_36	1122182.KB903838_gene3994	5.445e-28	128.0	COG3801@1|root,COG3801@2|Bacteria,2IR6E@201174|Actinobacteria,4DG1J@85008|Micromonosporales	201174|Actinobacteria	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
TLS1_k127_7212262_47	350054.Mflv_5593	6.573e-11	68.0	COG1426@1|root,COG1426@2|Bacteria,2H4EK@201174|Actinobacteria,23DIA@1762|Mycobacteriaceae	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
TLS1_k127_7212262_45	1996.JOFO01000032_gene1309	4.793e-15	89.0	2DS6Y@1|root,33EU1@2|Bacteria,2I89N@201174|Actinobacteria	201174|Actinobacteria	S	Sporulation protein YtfJ (Spore_YtfJ)	-	-	-	-	-	-	-	-	-	-	-	-	Spore_YtfJ
TLS1_k127_7212262_0	1122138.AQUZ01000023_gene7907	3.329e-163	525.0	COG0477@1|root,COG2814@2|Bacteria,2GNBV@201174|Actinobacteria,4DTSE@85009|Propionibacteriales	201174|Actinobacteria	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS1_k127_7212262_33	1380390.JIAT01000009_gene943	2.3e-35	142.0	COG0607@1|root,COG0607@2|Bacteria,2IKTC@201174|Actinobacteria,4CQJC@84995|Rubrobacteria	84995|Rubrobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TLS1_k127_7212262_28	469383.Cwoe_3355	1.444e-49	187.0	COG3832@1|root,COG3832@2|Bacteria,2IQUJ@201174|Actinobacteria	201174|Actinobacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS1_k127_7212262_11	1120950.KB892731_gene3758	3.964e-77	265.0	COG3832@1|root,COG3832@2|Bacteria,2IE7C@201174|Actinobacteria,4DRPP@85009|Propionibacteriales	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS1_k127_7212262_30	1246995.AFR_10830	1.597e-48	176.0	COG0640@1|root,COG0640@2|Bacteria,2IM1K@201174|Actinobacteria,4DE6N@85008|Micromonosporales	201174|Actinobacteria	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
TLS1_k127_7212262_39	379066.GAU_0527	1.781e-24	110.0	COG1595@1|root,COG1595@2|Bacteria,1ZT0A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS1_k127_7212262_21	408672.NBCG_04167	1.306e-57	210.0	COG1309@1|root,COG1309@2|Bacteria,2IJ18@201174|Actinobacteria,4DWUE@85009|Propionibacteriales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS1_k127_7212262_44	1382356.JQMP01000001_gene767	1.616e-19	94.0	COG3576@1|root,COG3576@2|Bacteria,2GBHJ@200795|Chloroflexi,27YES@189775|Thermomicrobia	189775|Thermomicrobia	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS1_k127_7212262_19	404589.Anae109_3656	8.38e-64	229.0	COG1309@1|root,COG1309@2|Bacteria,1RADD@1224|Proteobacteria,43AQM@68525|delta/epsilon subdivisions,2X64I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS1_k127_7212262_24	316055.RPE_2376	1.863e-54	204.0	COG1028@1|root,COG1028@2|Bacteria,1P9R4@1224|Proteobacteria,2TUAM@28211|Alphaproteobacteria,3K6BW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS1_k127_7212262_9	471853.Bcav_4065	1.359e-86	302.0	COG2141@1|root,COG2141@2|Bacteria,2GM7W@201174|Actinobacteria	201174|Actinobacteria	C	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS1_k127_7212262_40	485913.Krac_1097	3.29e-24	113.0	2BWWR@1|root,2ZG0F@2|Bacteria	2|Bacteria	S	pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS1_k127_7212262_42	330084.JNYZ01000051_gene8947	1.546e-22	101.0	2EHMA@1|root,33BD2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ABM
TLS1_k127_7212262_54	926566.Terro_0751	3.954e-07	62.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y3FE@57723|Acidobacteria,2JIZ4@204432|Acidobacteriia	204432|Acidobacteriia	KU	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
TLS1_k127_7212262_52	1229172.JQFA01000002_gene4360	1.836e-09	70.0	COG0823@1|root,COG0823@2|Bacteria,1G8I3@1117|Cyanobacteria,1HCNX@1150|Oscillatoriales	1117|Cyanobacteria	U	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
TLS1_k127_7212262_49	935866.JAER01000006_gene3252	1.28e-10	69.0	COG1595@1|root,COG1595@2|Bacteria,2GRZW@201174|Actinobacteria,4DSMI@85009|Propionibacteriales	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
TLS1_k127_7212262_57	1122602.ATXP01000021_gene139	0.0006651	43.0	COG1961@1|root,COG1961@2|Bacteria,2I8HV@201174|Actinobacteria	201174|Actinobacteria	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS1_k127_7212262_46	1194165.CAJF01000005_gene2380	9.969e-12	71.0	COG0604@1|root,COG0604@2|Bacteria,2I8SZ@201174|Actinobacteria,4FPGS@85023|Microbacteriaceae	201174|Actinobacteria	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7212262_55	479432.Sros_4234	6.775e-05	53.0	COG0604@1|root,COG0604@2|Bacteria,2I8SZ@201174|Actinobacteria,4EN55@85012|Streptosporangiales	201174|Actinobacteria	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7212262_43	479432.Sros_4234	3.674e-21	99.0	COG0604@1|root,COG0604@2|Bacteria,2I8SZ@201174|Actinobacteria,4EN55@85012|Streptosporangiales	201174|Actinobacteria	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7212262_29	526225.Gobs_0023	2.136e-49	184.0	COG1670@1|root,COG1670@2|Bacteria,2HF95@201174|Actinobacteria,4EWH1@85013|Frankiales	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.82	ko:K00663	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	Acetyltransf_3
TLS1_k127_7212262_17	526225.Gobs_0020	1.36e-67	232.0	arCOG06733@1|root,313GU@2|Bacteria,2ICAF@201174|Actinobacteria,4ET4U@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7215137_4	479434.Sthe_1019	4.995e-37	159.0	COG0457@1|root,COG0457@2|Bacteria,2G6Q2@200795|Chloroflexi	200795|Chloroflexi	S	PFAM TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2
TLS1_k127_7215137_0	926569.ANT_25540	3.574e-148	490.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,2G5K6@200795|Chloroflexi	200795|Chloroflexi	L	PHP domain protein	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_thumb,HHH_5,HHH_8,PHP
TLS1_k127_7215137_5	502025.Hoch_0319	1.462e-29	138.0	COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,42PVX@68525|delta/epsilon subdivisions,2WIJ8@28221|Deltaproteobacteria,2Z2WU@29|Myxococcales	28221|Deltaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF
TLS1_k127_7215137_2	867845.KI911784_gene1094	8.177e-41	173.0	COG2199@1|root,COG2202@1|root,COG2203@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria,2G87Y@200795|Chloroflexi	200795|Chloroflexi	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GGDEF,HisKA_7TM,PAS_4,PAS_8
TLS1_k127_7215137_3	436229.JOEH01000022_gene595	5.448e-39	169.0	COG0726@1|root,COG0726@2|Bacteria	2|Bacteria	G	polysaccharide deacetylase	-	-	3.2.1.156	ko:K15531	-	-	-	-	ko00000,ko01000	-	GH8	-	Beta_helix,CBM60,CBM9_1,Glyco_hydro_8,PD40,PKD,Polysacc_deac_1,SprB
TLS1_k127_7215137_6	251221.35213025	1.363e-26	128.0	COG3055@1|root,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,Kelch_1,Kelch_6
TLS1_k127_7215137_1	1249627.D779_2161	1.034e-66	240.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1MUDN@1224|Proteobacteria,1RMMG@1236|Gammaproteobacteria,1WXIJ@135613|Chromatiales	135613|Chromatiales	P	Metallo-beta-lactamase superfamily	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
TLS1_k127_7252779_2	471853.Bcav_4095	1.454e-28	123.0	COG4315@1|root,COG4315@2|Bacteria,2GNDV@201174|Actinobacteria	201174|Actinobacteria	S	Secreted repeat of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	Lipoprotein_15
TLS1_k127_7252779_0	1227487.C474_06312	5.961e-73	252.0	COG3371@1|root,arCOG02008@2157|Archaea,2XWKR@28890|Euryarchaeota,23VDZ@183963|Halobacteria	183963|Halobacteria	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
TLS1_k127_7252779_5	1001240.GY21_15160	2.644e-12	72.0	COG4113@1|root,COG4113@2|Bacteria,2GR4U@201174|Actinobacteria,4FQIB@85023|Microbacteriaceae	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS1_k127_7252779_3	1306174.JODP01000006_gene2994	1.725e-22	98.0	COG4118@1|root,COG4118@2|Bacteria,2IQGB@201174|Actinobacteria	201174|Actinobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
TLS1_k127_7252779_1	399741.Spro_1038	1.936e-32	130.0	COG3744@1|root,COG3744@2|Bacteria,1N0J5@1224|Proteobacteria,1S6CA@1236|Gammaproteobacteria,404B6@613|Serratia	1236|Gammaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS1_k127_7252779_4	266940.Krad_2284	1.599e-12	81.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
TLS1_k127_7349131_0	498761.HM1_2322	3.848e-227	733.0	COG1185@1|root,COG1185@2|Bacteria,1TQDW@1239|Firmicutes,248RW@186801|Clostridia	186801|Clostridia	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
TLS1_k127_7349131_3	1158338.JNLJ01000001_gene371	8.168e-113	387.0	COG0136@1|root,COG0136@2|Bacteria,2G3QW@200783|Aquificae	200783|Aquificae	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
TLS1_k127_7349131_5	525904.Tter_0795	5.522e-59	214.0	COG1573@1|root,COG1573@2|Bacteria,2NP99@2323|unclassified Bacteria	2|Bacteria	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS1_k127_7349131_1	1120973.AQXL01000128_gene2793	2.412e-190	619.0	COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,4HAAP@91061|Bacilli,277WB@186823|Alicyclobacillaceae	91061|Bacilli	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
TLS1_k127_7349131_2	370438.PTH_1293	2.988e-125	449.0	COG1674@1|root,COG1674@2|Bacteria,1TPJR@1239|Firmicutes,247KM@186801|Clostridia,260AY@186807|Peptococcaceae	186801|Clostridia	D	DNA segregation ATPase FtsK SpoIIIE	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
TLS1_k127_7349131_8	357808.RoseRS_0529	1.499e-16	93.0	COG1426@1|root,COG1426@2|Bacteria,2G773@200795|Chloroflexi,375R5@32061|Chloroflexia	32061|Chloroflexia	S	SMART helix-turn-helix domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4115,HTH_25
TLS1_k127_7349131_7	42256.RradSPS_0385	5.349e-34	139.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,2IQ8T@201174|Actinobacteria,4CPMK@84995|Rubrobacteria	84995|Rubrobacteria	S	Competence-damaged protein	-	-	3.5.1.42	ko:K03742	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
TLS1_k127_7349131_4	479434.Sthe_1991	1.285e-61	235.0	COG0773@1|root,COG0773@2|Bacteria,2G5J4@200795|Chloroflexi,27XZD@189775|Thermomicrobia	189775|Thermomicrobia	M	Mur ligase family, catalytic domain	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS1_k127_7349131_10	926560.KE387023_gene2483	3.025e-08	66.0	293K9@1|root,2ZR28@2|Bacteria	2|Bacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
TLS1_k127_7349131_6	485913.Krac_12358	4.029e-48	178.0	COG1666@1|root,COG1666@2|Bacteria,2G6TD@200795|Chloroflexi	200795|Chloroflexi	S	Belongs to the UPF0234 family	-	-	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
TLS1_k127_7349131_9	1122132.AQYH01000001_gene859	1.902e-15	83.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSB1@28211|Alphaproteobacteria,4B84V@82115|Rhizobiaceae	28211|Alphaproteobacteria	EH	Belongs to the TPP enzyme family	MA20_00650	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS1_k127_736530_6	1123072.AUDH01000005_gene1650	2.958e-13	74.0	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,2U72D@28211|Alphaproteobacteria,2JRSW@204441|Rhodospirillales	204441|Rhodospirillales	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
TLS1_k127_736530_2	56107.Cylst_0473	8.401e-72	262.0	COG2215@1|root,COG2215@2|Bacteria,1G36H@1117|Cyanobacteria,1HQQ3@1161|Nostocales	1117|Cyanobacteria	S	High-affinity nickel-transport protein	-	-	-	ko:K08970	-	-	-	-	ko00000,ko02000	2.A.52.2	-	-	DsbD_2,NicO
TLS1_k127_736530_3	861299.J421_3711	4.037e-71	265.0	COG1024@1|root,COG1024@2|Bacteria,1ZSTH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Enoyl-CoA hydratase/isomerase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
TLS1_k127_736530_8	1128421.JAGA01000003_gene2714	1.131e-08	65.0	COG4848@1|root,COG4848@2|Bacteria	2|Bacteria	L	Belongs to the UPF0354 family	ytpQ	-	-	-	-	-	-	-	-	-	-	-	DUF1444
TLS1_k127_736530_1	1117108.PAALTS15_16361	1.145e-76	271.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,4HBW0@91061|Bacilli,26SS6@186822|Paenibacillaceae	91061|Bacilli	I	Belongs to the enoyl-CoA hydratase isomerase family	paaF	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS1_k127_736530_7	997346.HMPREF9374_3780	7.758e-09	65.0	COG3224@1|root,COG3224@2|Bacteria,1V83H@1239|Firmicutes,4HJC6@91061|Bacilli,27C4H@186824|Thermoactinomycetaceae	91061|Bacilli	S	Methylmuconolactone methyl-isomerase	ethD	-	-	-	-	-	-	-	-	-	-	-	EthD
TLS1_k127_736530_5	1254432.SCE1572_07235	5.856e-24	116.0	COG2021@1|root,COG2021@2|Bacteria,1PG00@1224|Proteobacteria,439DK@68525|delta/epsilon subdivisions,2X4NG@28221|Deltaproteobacteria,2YZAN@29|Myxococcales	28221|Deltaproteobacteria	E	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS1_k127_736530_4	67257.JODR01000037_gene1561	1.057e-30	139.0	COG1853@1|root,COG1853@2|Bacteria,2GPJS@201174|Actinobacteria	201174|Actinobacteria	K	PFAM flavin reductase domain protein, FMN-binding	-	-	-	ko:K16048	ko00984,ko01100,map00984,map01100	-	R09819	RC00236	ko00000,ko00001,ko01000	-	-	-	Flavin_Reduct
TLS1_k127_736530_0	1306406.ASHX01000001_gene778	3.095e-133	448.0	COG0114@1|root,COG0114@2|Bacteria,2GKWY@201174|Actinobacteria	201174|Actinobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	GO:0003674,GO:0003824,GO:0004333,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
TLS1_k127_7399566_30	378806.STAUR_7629	2.83e-42	177.0	COG1680@1|root,COG1680@2|Bacteria,1R8N7@1224|Proteobacteria,42WBG@68525|delta/epsilon subdivisions,2WS3Q@28221|Deltaproteobacteria,2YY0X@29|Myxococcales	28221|Deltaproteobacteria	V	Beta-lactamase	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase
TLS1_k127_7399566_60	543632.JOJL01000014_gene9178	8.841e-06	57.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS1_k127_7399566_34	196162.Noca_1391	5.75e-37	143.0	COG1158@1|root,COG1158@2|Bacteria,2IKUK@201174|Actinobacteria,4DR4P@85009|Propionibacteriales	201174|Actinobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7399566_8	1110697.NCAST_34_04800	4.922e-100	332.0	COG1801@1|root,COG1801@2|Bacteria,2GMSP@201174|Actinobacteria,4FYDM@85025|Nocardiaceae	201174|Actinobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
TLS1_k127_7399566_1	903818.KI912268_gene3392	1.036e-159	515.0	COG0513@1|root,COG0513@2|Bacteria,3Y2M6@57723|Acidobacteria	57723|Acidobacteria	L	DEAD DEAH box helicase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
TLS1_k127_7399566_25	35754.JNYJ01000004_gene5920	5.047e-48	182.0	COG2606@1|root,COG2606@2|Bacteria,2IHS8@201174|Actinobacteria,4DDH5@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily	ybaK	-	-	ko:K03976	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
TLS1_k127_7399566_52	479435.Kfla_2107	9.596e-11	69.0	COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,2IAS1@201174|Actinobacteria,4DWMF@85009|Propionibacteriales	201174|Actinobacteria	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,TPR_12,Trans_reg_C
TLS1_k127_7399566_41	768706.Desor_4040	3.542e-26	113.0	COG3877@1|root,COG3877@2|Bacteria,1VAFG@1239|Firmicutes,24MSP@186801|Clostridia,262AG@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF2089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2089
TLS1_k127_7399566_51	1382356.JQMP01000003_gene1561	6.896e-13	81.0	COG3595@1|root,COG3595@2|Bacteria,2GA1M@200795|Chloroflexi,27Z52@189775|Thermomicrobia	189775|Thermomicrobia	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
TLS1_k127_7399566_59	926569.ANT_06730	7.318e-06	57.0	2E4Y1@1|root,32ZRZ@2|Bacteria,2G9AY@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7399566_2	190650.CC_3125	1.48e-137	452.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2U0BD@28211|Alphaproteobacteria,2KK0G@204458|Caulobacterales	204458|Caulobacterales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS1_k127_7399566_6	234267.Acid_5173	3.654e-105	362.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,3Y64H@57723|Acidobacteria	57723|Acidobacteria	T	histidine kinase A domain protein domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,Response_reg
TLS1_k127_7399566_21	1122951.ATUE01000008_gene280	1.294e-59	216.0	COG0412@1|root,COG0412@2|Bacteria	2|Bacteria	Q	carboxymethylenebutenolidase activity	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
TLS1_k127_7399566_26	469383.Cwoe_5036	8.158e-48	180.0	COG0177@1|root,COG0177@2|Bacteria,2GNE5@201174|Actinobacteria	201174|Actinobacteria	L	PFAM HhH-GPD family protein	-	-	-	-	-	-	-	-	-	-	-	-	HhH-GPD
TLS1_k127_7399566_3	1341151.ASZU01000003_gene2279	2.286e-125	411.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	scpD	-	3.4.17.18	ko:K05996	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	P_proprotein,Peptidase_M14
TLS1_k127_7399566_19	1128421.JAGA01000002_gene1190	4.918e-67	232.0	COG3059@1|root,COG3059@2|Bacteria	2|Bacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF417,DoxX
TLS1_k127_7399566_40	1385935.N836_35030	1.078e-26	116.0	2DMJE@1|root,32RYR@2|Bacteria,1G6SI@1117|Cyanobacteria,1HBXF@1150|Oscillatoriales	1117|Cyanobacteria	S	Domain of unknown function (DUF4112)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4112
TLS1_k127_7399566_11	1463934.JOCF01000056_gene1903	2.947e-94	320.0	COG2321@1|root,COG2321@2|Bacteria,2H3UT@201174|Actinobacteria	201174|Actinobacteria	S	Neutral zinc metallopeptidase	ypfJ	GO:0005575,GO:0005576	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
TLS1_k127_7399566_9	103733.JNYO01000003_gene8263	6.314e-97	328.0	COG2378@1|root,COG2378@2|Bacteria,2GKFU@201174|Actinobacteria,4DYI7@85010|Pseudonocardiales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
TLS1_k127_7399566_13	710111.FraQA3DRAFT_4730	3.002e-83	287.0	COG1801@1|root,COG1801@2|Bacteria	2|Bacteria	L	Protein of unknown function DUF72	yunF	-	-	-	-	-	-	-	-	-	-	-	DUF72
TLS1_k127_7399566_32	1380390.JIAT01000009_gene2005	3.402e-41	170.0	COG2047@1|root,COG2047@2|Bacteria,2I2H9@201174|Actinobacteria,4CP8R@84995|Rubrobacteria	84995|Rubrobacteria	S	PAC2 family	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
TLS1_k127_7399566_7	1463901.JOIY01000033_gene3696	7.17e-105	356.0	COG0667@1|root,COG0667@2|Bacteria,2GJWD@201174|Actinobacteria	201174|Actinobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS1_k127_7399566_4	1121935.AQXX01000064_gene3308	2.787e-123	411.0	COG4257@1|root,COG4257@2|Bacteria,1QR8W@1224|Proteobacteria,1RQM4@1236|Gammaproteobacteria,1XPTW@135619|Oceanospirillales	135619|Oceanospirillales	V	Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid	-	-	-	ko:K18235	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	-
TLS1_k127_7399566_24	405948.SACE_1731	1.209e-54	202.0	COG2329@1|root,COG2329@2|Bacteria,2GTB1@201174|Actinobacteria,4E4ZQ@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain of unknown function (DUF3291)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3291
TLS1_k127_7399566_0	1380386.JIAW01000006_gene1255	2.832e-187	596.0	COG3011@1|root,COG3011@2|Bacteria,2GMSU@201174|Actinobacteria,232YP@1762|Mycobacteriaceae	201174|Actinobacteria	S	Lipase maturation factor	LMF	-	-	-	-	-	-	-	-	-	-	-	LMF1
TLS1_k127_7399566_18	1382306.JNIM01000001_gene1633	7.54e-68	244.0	COG2141@1|root,COG2141@2|Bacteria,2G873@200795|Chloroflexi	200795|Chloroflexi	C	COGs COG2141 Coenzyme F420-dependent N5 N10-methylene tetrahydromethanopterin reductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS1_k127_7399566_23	1313172.YM304_20690	1.007e-56	203.0	COG2606@1|root,COG2606@2|Bacteria,2GKUX@201174|Actinobacteria	201174|Actinobacteria	S	YbaK prolyl-tRNA synthetase associated region	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
TLS1_k127_7399566_12	1382359.JIAL01000001_gene1505	3.894e-86	304.0	COG0568@1|root,COG0568@2|Bacteria,3Y2XG@57723|Acidobacteria,2JHX1@204432|Acidobacteriia	204432|Acidobacteriia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS1_k127_7399566_33	1304865.JAGF01000001_gene1407	1.743e-37	151.0	COG4635@1|root,COG4635@2|Bacteria	2|Bacteria	CH	menaquinone-dependent protoporphyrinogen oxidase activity	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
TLS1_k127_7399566_37	1125971.ASJB01000064_gene6508	1.576e-33	138.0	COG4635@1|root,COG4635@2|Bacteria,2IMZZ@201174|Actinobacteria	201174|Actinobacteria	CH	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
TLS1_k127_7399566_38	1385518.N798_08395	1.309e-32	133.0	2C4FF@1|root,30I7M@2|Bacteria,2IJJV@201174|Actinobacteria,4FGD4@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7399566_29	1035308.AQYY01000001_gene2114	1.1e-44	166.0	COG3118@1|root,COG3118@2|Bacteria,1VA3Y@1239|Firmicutes,24MM5@186801|Clostridia	186801|Clostridia	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
TLS1_k127_7399566_53	555088.DealDRAFT_2728	1.622e-10	72.0	COG4758@1|root,COG4758@2|Bacteria,1UITP@1239|Firmicutes,24NAQ@186801|Clostridia	186801|Clostridia	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154,Toast_rack_N
TLS1_k127_7399566_57	1304284.L21TH_2078	2.836e-09	66.0	COG1983@1|root,COG1983@2|Bacteria,1VKBQ@1239|Firmicutes,24QU9@186801|Clostridia,36NYT@31979|Clostridiaceae	186801|Clostridia	KT	PspC domain	-	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	PspC
TLS1_k127_7399566_43	926560.KE387027_gene896	1.922e-25	119.0	COG4758@1|root,COG4758@2|Bacteria,1WKNW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154
TLS1_k127_7399566_44	477641.MODMU_5084	1.067e-23	111.0	2E9HK@1|root,333QQ@2|Bacteria,2I89Z@201174|Actinobacteria,4ETI2@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7399566_45	285535.JOEY01000082_gene9388	5.82e-22	102.0	COG4803@1|root,COG4803@2|Bacteria,2IHYU@201174|Actinobacteria	201174|Actinobacteria	S	membrane protein of uknown function UCP014873	-	-	-	-	-	-	-	-	-	-	-	-	DUF1269
TLS1_k127_7399566_54	1112212.JH584235_gene2729	3.624e-10	63.0	COG1278@1|root,COG1278@2|Bacteria,1QRMX@1224|Proteobacteria,2V17U@28211|Alphaproteobacteria,2KB7U@204457|Sphingomonadales	204457|Sphingomonadales	K	Cold shock protein domain	-	-	-	-	-	-	-	-	-	-	-	-	CSD
TLS1_k127_7399566_58	1120950.KB892830_gene5046	1.073e-08	60.0	COG2524@1|root,COG2524@2|Bacteria,2I1DT@201174|Actinobacteria,4DWBB@85009|Propionibacteriales	201174|Actinobacteria	K	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS1_k127_7399566_56	448385.sce6988	1.558e-09	70.0	COG0477@1|root,COG2814@2|Bacteria,1QRUM@1224|Proteobacteria,42MFJ@68525|delta/epsilon subdivisions,2X2AQ@28221|Deltaproteobacteria,2Z25Q@29|Myxococcales	28221|Deltaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
TLS1_k127_7399566_42	1380390.JIAT01000010_gene4020	1.16e-25	110.0	COG0662@1|root,COG0662@2|Bacteria,2HRRH@201174|Actinobacteria,4CTU5@84995|Rubrobacteria	84995|Rubrobacteria	G	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS1_k127_7399566_22	526225.Gobs_2476	7.627e-57	203.0	COG0454@1|root,COG0454@2|Bacteria,2HX8M@201174|Actinobacteria,4EUEX@85013|Frankiales	201174|Actinobacteria	K	Protein of unknown function (DUF3616)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3616
TLS1_k127_7399566_31	390989.JOEG01000006_gene878	2.342e-41	163.0	COG2334@1|root,COG2334@2|Bacteria,2IJNW@201174|Actinobacteria,4DDSX@85008|Micromonosporales	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	2.7.1.39	ko:K02204	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	APH
TLS1_k127_7399566_46	644966.Tmar_2347	1.362e-21	107.0	COG0739@1|root,COG3583@1|root,COG0739@2|Bacteria,COG3583@2|Bacteria,1TRWJ@1239|Firmicutes,24A2J@186801|Clostridia,3WCJZ@538999|Clostridiales incertae sedis	186801|Clostridia	M	G5	-	-	-	-	-	-	-	-	-	-	-	-	G5,LysM,Peptidase_M23
TLS1_k127_7399566_14	2002.JOEQ01000074_gene6426	2.32e-82	276.0	COG1917@1|root,COG1917@2|Bacteria,2IIQD@201174|Actinobacteria,4EJQH@85012|Streptosporangiales	201174|Actinobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS1_k127_7399566_35	1869.MB27_13905	1.881e-35	138.0	COG0346@1|root,COG0346@2|Bacteria,2GS59@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase,Glyoxalase_2
TLS1_k127_7399566_17	1386089.N865_04285	1.242e-73	253.0	COG0346@1|root,COG0346@2|Bacteria,2IGUF@201174|Actinobacteria,4FGBK@85021|Intrasporangiaceae	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS1_k127_7399566_20	288000.BBta_5500	6.482e-67	239.0	COG2267@1|root,COG2267@2|Bacteria,1MYEX@1224|Proteobacteria,2U5YK@28211|Alphaproteobacteria,3K1PM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Serine aminopeptidase, S33	-	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
TLS1_k127_7399566_16	485913.Krac_10783	1.624e-74	258.0	COG3382@1|root,COG3382@2|Bacteria,2G96A@200795|Chloroflexi	200795|Chloroflexi	S	B3/4 domain	-	-	-	-	-	-	-	-	-	-	-	-	B3_4
TLS1_k127_7399566_49	485913.Krac_7038	3.7e-18	90.0	2BVHN@1|root,32SWN@2|Bacteria	2|Bacteria	S	Pfam:DUF385	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
TLS1_k127_7399566_5	1123023.JIAI01000002_gene5036	1.663e-113	373.0	COG1595@1|root,COG1595@2|Bacteria,2GJIZ@201174|Actinobacteria,4E28A@85010|Pseudonocardiales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS1_k127_7399566_48	1306406.ASHX01000002_gene4539	1.671e-20	103.0	COG1404@1|root,COG1404@2|Bacteria,2HJRK@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7399566_10	314265.R2601_15632	1.981e-96	336.0	COG3590@1|root,COG3590@2|Bacteria,1QQ5Q@1224|Proteobacteria,2TVBZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7399566_15	314265.R2601_15627	2.407e-79	301.0	COG2333@1|root,COG2333@2|Bacteria,1PZYY@1224|Proteobacteria,2UJ6W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	competence protein COMEC	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7399566_50	208439.AJAP_16315	2.519e-14	81.0	COG0346@1|root,COG0346@2|Bacteria,2IM7G@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS1_k127_7399566_28	1246995.AFR_16350	9.306e-46	176.0	COG0491@1|root,COG0491@2|Bacteria,2HGYG@201174|Actinobacteria,4DHF6@85008|Micromonosporales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS1_k127_7399566_39	99598.Cal7507_2420	3.78e-27	123.0	29VZ4@1|root,30HHA@2|Bacteria,1GHMM@1117|Cyanobacteria,1HRX7@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7405889_2	1157640.AQWO01000010_gene2792	1.527e-51	190.0	COG0745@1|root,COG0745@2|Bacteria,2GJE6@201174|Actinobacteria	201174|Actinobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS1_k127_7405889_1	1232410.KI421420_gene3185	2.854e-66	248.0	COG5002@1|root,COG5002@2|Bacteria,1QU7C@1224|Proteobacteria,439YG@68525|delta/epsilon subdivisions,2WUBB@28221|Deltaproteobacteria,43UAD@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS1_k127_7405889_3	529818.AMSG_07677T0	3.9e-31	139.0	KOG0379@1|root,KOG4293@1|root,KOG0379@2759|Eukaryota,KOG4293@2759|Eukaryota	2759|Eukaryota	U	DOMON domain-containing protein	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005794,GO:0005802,GO:0012505,GO:0031410,GO:0031982,GO:0031984,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0097708,GO:0098791	-	-	-	-	-	-	-	-	-	-	Cytochrom_B561,Cytochrom_C_asm,DM13,DOMON,Kelch_4
TLS1_k127_7405889_0	525904.Tter_0973	2.287e-139	455.0	COG3842@1|root,COG3842@2|Bacteria,2NNU0@2323|unclassified Bacteria	2|Bacteria	E	ATPases associated with a variety of cellular activities	ugpC	-	-	ko:K10112,ko:K10195	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00202,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.11	-	iJN678.ggtA	ABC_tran,TOBE,TOBE_2
TLS1_k127_7422454_0	309801.trd_0495	7.437e-182	574.0	COG2225@1|root,COG2225@2|Bacteria,2G63R@200795|Chloroflexi,27Y0V@189775|Thermomicrobia	189775|Thermomicrobia	C	Malate synthase	-	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
TLS1_k127_7422454_1	1385518.N798_16410	3.252e-112	393.0	COG2114@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4FE8Z@85021|Intrasporangiaceae	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_12
TLS1_k127_7423444_0	479434.Sthe_3420	4.861e-102	336.0	COG1132@1|root,COG1132@2|Bacteria,2G5P7@200795|Chloroflexi,27XZA@189775|Thermomicrobia	189775|Thermomicrobia	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS1_k127_7423444_4	262724.TT_C1007	1.895e-18	98.0	COG1765@1|root,COG1765@2|Bacteria,1WJW4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	redox protein regulator of disulfide bond formation	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
TLS1_k127_7423444_2	1207063.P24_04694	5.259e-83	285.0	COG4122@1|root,COG4122@2|Bacteria,1RB34@1224|Proteobacteria,2VGIH@28211|Alphaproteobacteria,2JS0H@204441|Rhodospirillales	204441|Rhodospirillales	S	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
TLS1_k127_7423444_6	1122182.KB903814_gene3514	0.0002075	48.0	COG0766@1|root,COG0766@2|Bacteria,2GJPW@201174|Actinobacteria,4DHC1@85008|Micromonosporales	201174|Actinobacteria	M	Helix-turn-helix domain	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase,HTH_3
TLS1_k127_7423444_5	452652.KSE_16980	2.371e-13	77.0	2AN8T@1|root,327DN@2|Bacteria,2I81P@201174|Actinobacteria,2M393@2063|Kitasatospora	201174|Actinobacteria	S	Domain of unknown function (DUF4395)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4395
TLS1_k127_7423444_1	498761.HM1_1428	3.359e-90	310.0	COG0002@1|root,COG0002@2|Bacteria,1TPVI@1239|Firmicutes,247R3@186801|Clostridia	186801|Clostridia	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
TLS1_k127_7423444_3	1140.Synpcc7942_1896	1.716e-61	228.0	COG1364@1|root,COG1364@2|Bacteria,1G1H7@1117|Cyanobacteria,1GZ07@1129|Synechococcus	1117|Cyanobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.argJ	ArgJ
TLS1_k127_7521792_4	383372.Rcas_1903	7.535e-71	269.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,2G5VK@200795|Chloroflexi,37589@32061|Chloroflexia	32061|Chloroflexia	E	glutamate synthase, alpha subunit domain protein	-	-	1.4.7.1	ko:K00284	ko00630,ko00910,ko01120,map00630,map00910,map01120	-	R00021,R10086	RC00006,RC00010	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
TLS1_k127_7521792_0	635013.TherJR_0702	4.693e-146	473.0	COG0004@1|root,COG0004@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,2603A@186807|Peptococcaceae	186801|Clostridia	U	TIGRFAM Ammonium transporter	nrgA	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
TLS1_k127_7521792_7	237727.NAP1_11003	3.185e-57	205.0	29KMP@1|root,307IZ@2|Bacteria,1REJ6@1224|Proteobacteria,2UAW7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4287)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4287
TLS1_k127_7521792_8	1134474.O59_001710	7.074e-57	214.0	COG0642@1|root,COG0784@1|root,COG2202@1|root,COG3290@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3290@2|Bacteria,1NRP8@1224|Proteobacteria,1RWXK@1236|Gammaproteobacteria,1FFRE@10|Cellvibrio	1224|Proteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,HATPase_c,HisKA,PAS,PAS_9,Response_reg
TLS1_k127_7521792_2	1125863.JAFN01000001_gene401	1.326e-112	383.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,42P72@68525|delta/epsilon subdivisions,2WKRS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	D-isomer specific 2-hydroxyacid dehydrogenase	gyaR	-	1.1.1.26	ko:K00015,ko:K15893	ko00260,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map01100,map01110,map01120,map01130,map01200	M00532	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS1_k127_7521792_1	264732.Moth_1955	7.753e-141	464.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,42EKB@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM aminotransferase, class I	-	-	2.6.1.1	ko:K00812,ko:K10907	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS1_k127_7521792_5	1128421.JAGA01000003_gene2936	8.854e-70	248.0	COG0506@1|root,COG0506@2|Bacteria,2NPED@2323|unclassified Bacteria	2|Bacteria	E	Proline dehydrogenase	-	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
TLS1_k127_7521792_12	309801.trd_A0913	6.304e-17	86.0	COG4911@1|root,COG4911@2|Bacteria,2G7A8@200795|Chloroflexi,27YIV@189775|Thermomicrobia	189775|Thermomicrobia	S	Uncharacterized conserved protein (DUF2203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2203
TLS1_k127_7521792_13	867903.ThesuDRAFT_02230	3.386e-12	74.0	COG0500@1|root,COG1547@1|root,COG1547@2|Bacteria,COG2226@2|Bacteria,1V45D@1239|Firmicutes	1239|Firmicutes	Q	SAM-dependent methyltransferase	ubiE7	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS1_k127_7521792_11	1232410.KI421421_gene3509	2.093e-19	99.0	COG0607@1|root,COG0607@2|Bacteria,1PE42@1224|Proteobacteria,42V5T@68525|delta/epsilon subdivisions,2WSHC@28221|Deltaproteobacteria,43VCQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TLS1_k127_7521792_14	1121272.KB903256_gene5557	2.587e-06	61.0	COG3055@1|root,COG3055@2|Bacteria,2ICH5@201174|Actinobacteria,4DFPE@85008|Micromonosporales	201174|Actinobacteria	S	Galactose oxidase, central domain	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_1,Kelch_6
TLS1_k127_7521792_15	1288494.EBAPG3_2670	4.123e-05	55.0	COG2010@1|root,COG2010@2|Bacteria,1NE41@1224|Proteobacteria,2WEJ6@28216|Betaproteobacteria,373D7@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Cytochrome c, class I	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
TLS1_k127_7521792_10	1313172.YM304_04030	3.335e-25	113.0	COG0723@1|root,COG0723@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on diphenols and related substances as donors	-	-	1.10.9.1	ko:K02636,ko:K03886	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00151,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Rieske
TLS1_k127_7521792_9	485913.Krac_6666	3.242e-41	162.0	COG1290@1|root,COG1290@2|Bacteria	2|Bacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	pcmD	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C,Cytochrome_B
TLS1_k127_7521792_3	1313172.YM304_04010	1.347e-97	339.0	COG1290@1|root,COG1290@2|Bacteria,2GJ1E@201174|Actinobacteria,4CN9T@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Cytochrome b/b6/petB	-	-	-	ko:K03891	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_B_N_2
TLS1_k127_7521792_6	485913.Krac_8409	1.915e-62	226.0	COG0493@1|root,COG0493@2|Bacteria	2|Bacteria	C	'glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2
TLS1_k127_7592825_1	1382306.JNIM01000001_gene2555	2.836e-120	396.0	COG0536@1|root,COG0536@2|Bacteria,2G5ZT@200795|Chloroflexi	200795|Chloroflexi	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
TLS1_k127_7592825_3	926569.ANT_07430	2.477e-31	141.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,2G6Q7@200795|Chloroflexi	200795|Chloroflexi	M	Peptidoglycan-binding LysM	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23,SH3_3
TLS1_k127_7592825_0	479434.Sthe_1003	1.173e-184	590.0	COG1158@1|root,COG1158@2|Bacteria,2G5UQ@200795|Chloroflexi,27Y0Z@189775|Thermomicrobia	189775|Thermomicrobia	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
TLS1_k127_7592825_2	1048834.TC41_2571	5.411e-32	133.0	COG0800@1|root,COG0800@2|Bacteria,1TS0F@1239|Firmicutes,4HNFM@91061|Bacilli	91061|Bacilli	G	KDPG and KHG aldolase	-	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
TLS1_k127_7592825_4	568706.BN118_1406	2.242e-08	68.0	COG1028@1|root,COG1028@2|Bacteria,1R4UB@1224|Proteobacteria	1224|Proteobacteria	IQ	Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS1_k127_7598626_1	479432.Sros_1323	4.973e-137	465.0	COG2352@1|root,COG2352@2|Bacteria,2GKDB@201174|Actinobacteria,4EHTY@85012|Streptosporangiales	201174|Actinobacteria	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
TLS1_k127_7598626_5	443143.GM18_0237	2.955e-30	137.0	COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,43CC6@68525|delta/epsilon subdivisions,2X7N2@28221|Deltaproteobacteria,43UI6@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA
TLS1_k127_7598626_3	485913.Krac_12187	7.678e-40	156.0	COG0745@1|root,COG0745@2|Bacteria	485913.Krac_12187|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7598626_4	1394178.AWOO02000035_gene9048	2.464e-38	157.0	COG2020@1|root,COG2020@2|Bacteria,2IIDW@201174|Actinobacteria,4EJKI@85012|Streptosporangiales	201174|Actinobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
TLS1_k127_7598626_6	66373.JOFQ01000006_gene3113	5.874e-11	74.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_6,Acetyltransf_7,Acetyltransf_9
TLS1_k127_7598626_2	1385519.N801_05270	7.123e-56	206.0	COG4635@1|root,COG4635@2|Bacteria,2IQCQ@201174|Actinobacteria	201174|Actinobacteria	CH	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
TLS1_k127_7598626_0	1382356.JQMP01000003_gene1321	1.854e-282	907.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,2G5VK@200795|Chloroflexi,27Z18@189775|Thermomicrobia	189775|Thermomicrobia	E	GXGXG motif	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
TLS1_k127_7630935_19	945712.CULC22_00574	1.13e-26	114.0	COG5002@1|root,COG5002@2|Bacteria,2I3V4@201174|Actinobacteria,22R94@1653|Corynebacteriaceae	201174|Actinobacteria	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	mtrB	-	2.7.13.3	ko:K02484,ko:K07654	ko02020,map02020	M00461	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS_8,Response_reg
TLS1_k127_7630935_10	309801.trd_A0257	1.607e-56	209.0	COG5401@1|root,COG5401@2|Bacteria,2GA61@200795|Chloroflexi,27Y9M@189775|Thermomicrobia	189775|Thermomicrobia	S	Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane,Gmad2
TLS1_k127_7630935_11	269799.Gmet_3132	6.307e-54	198.0	COG1392@1|root,COG1392@2|Bacteria,1R4SP@1224|Proteobacteria,42SPV@68525|delta/epsilon subdivisions,2WPTH@28221|Deltaproteobacteria,43SW8@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
TLS1_k127_7630935_8	255470.cbdbA159	1.11e-70	258.0	COG4191@1|root,COG5002@1|root,COG4191@2|Bacteria,COG5002@2|Bacteria,2G67W@200795|Chloroflexi,34D12@301297|Dehalococcoidia	301297|Dehalococcoidia	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,sCache_like
TLS1_k127_7630935_23	179408.Osc7112_2568	9.378e-25	116.0	COG3568@1|root,COG3568@2|Bacteria,1G2PW@1117|Cyanobacteria	1117|Cyanobacteria	L	endonuclease exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS1_k127_7630935_20	1227499.C493_00690	1.984e-25	121.0	COG0584@1|root,arCOG00701@2157|Archaea,2XXRI@28890|Euryarchaeota,23W41@183963|Halobacteria	183963|Halobacteria	C	glycerophosphoryl diester phosphodiesterase	glpQ1	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
TLS1_k127_7630935_1	318424.EU78_02925	2.824e-117	391.0	COG0665@1|root,COG0665@2|Bacteria,2GNAE@201174|Actinobacteria,236K4@1762|Mycobacteriaceae	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
TLS1_k127_7630935_9	467200.ACFA01000439_gene1966	8.026e-63	240.0	COG2017@1|root,COG2017@2|Bacteria	2|Bacteria	G	converts alpha-aldose to the beta-anomer	JD73_05665	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
TLS1_k127_7630935_4	1463900.JOIX01000046_gene6858	6.368e-92	312.0	COG0500@1|root,COG2226@2|Bacteria,2HEKM@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase type 11	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
TLS1_k127_7630935_24	1449355.JQNR01000004_gene1416	1.033e-19	98.0	COG0640@1|root,COG0640@2|Bacteria,2IQDH@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
TLS1_k127_7630935_25	864702.OsccyDRAFT_3772	3.704e-11	70.0	COG2062@1|root,COG2062@2|Bacteria,1G6QD@1117|Cyanobacteria,1HBRK@1150|Oscillatoriales	1117|Cyanobacteria	T	Phosphohistidine phosphatase, SixA	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
TLS1_k127_7630935_16	309801.trd_A0797	2.067e-39	160.0	COG0394@1|root,COG0394@2|Bacteria,2G6TY@200795|Chloroflexi,27YKR@189775|Thermomicrobia	189775|Thermomicrobia	T	Low molecular weight phosphatase family	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
TLS1_k127_7630935_12	1382356.JQMP01000004_gene657	2.82e-48	181.0	COG0704@1|root,COG0704@2|Bacteria,2G6HD@200795|Chloroflexi,27XPS@189775|Thermomicrobia	189775|Thermomicrobia	P	Plays a role in the regulation of phosphate uptake	-	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
TLS1_k127_7630935_2	926569.ANT_27750	3.261e-111	392.0	COG1117@1|root,COG1117@2|Bacteria,2G646@200795|Chloroflexi	200795|Chloroflexi	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
TLS1_k127_7630935_7	1229780.BN381_30046	6.174e-72	253.0	COG0581@1|root,COG0581@2|Bacteria,2I2F2@201174|Actinobacteria,3UWRX@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
TLS1_k127_7630935_5	1313172.YM304_07700	3.32e-91	310.0	COG0573@1|root,COG0573@2|Bacteria,2GJDA@201174|Actinobacteria	201174|Actinobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
TLS1_k127_7630935_3	1313172.YM304_07690	4.665e-100	340.0	COG0226@1|root,COG0226@2|Bacteria,2GMY1@201174|Actinobacteria	201174|Actinobacteria	P	phosphate binding protein	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	HSP70,PBP_like,PBP_like_2
TLS1_k127_7630935_18	1382306.JNIM01000001_gene592	1.198e-32	139.0	COG0248@1|root,COG0248@2|Bacteria,2G776@200795|Chloroflexi	200795|Chloroflexi	FP	PFAM Ppx GppA phosphatase	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	CHAD,HD,Ppx-GppA
TLS1_k127_7630935_15	192952.MM_1377	1.285e-43	181.0	COG5607@1|root,arCOG05139@2157|Archaea,2Y7EP@28890|Euryarchaeota,2NA8G@224756|Methanomicrobia	224756|Methanomicrobia	F	CHAD	-	-	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH
TLS1_k127_7630935_0	1173027.Mic7113_2806	4.66e-231	738.0	COG0855@1|root,COG0855@2|Bacteria,1G1WA@1117|Cyanobacteria,1H9DA@1150|Oscillatoriales	1117|Cyanobacteria	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
TLS1_k127_7630935_14	485913.Krac_4989	8.71e-45	164.0	COG0393@1|root,COG0393@2|Bacteria	2|Bacteria	S	Putative heavy-metal-binding	ybjQ	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
TLS1_k127_7630935_22	485913.Krac_1345	4.455e-25	109.0	COG3536@1|root,COG3536@2|Bacteria,2G7H1@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF971)	-	-	-	-	-	-	-	-	-	-	-	-	DUF971
TLS1_k127_7630935_6	1243664.CAVL020000031_gene495	3.007e-76	280.0	COG4152@1|root,COG4152@2|Bacteria,1TR06@1239|Firmicutes,4H9RX@91061|Bacilli,1ZC9T@1386|Bacillus	91061|Bacilli	S	ABC transporter, ATP-binding protein	yhaQ	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS1_k127_7630935_17	1230341.MJ3_12610	3.065e-37	158.0	COG1668@1|root,COG1668@2|Bacteria,1TXRK@1239|Firmicutes,4HC9K@91061|Bacilli	91061|Bacilli	CP	ABC-type Na efflux pump, permease component	yhaP	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
TLS1_k127_7630935_21	1089553.Tph_c09930	4.107e-25	116.0	COG1793@1|root,COG1793@2|Bacteria,1U8ME@1239|Firmicutes,24B1F@186801|Clostridia,42F9R@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM ATP dependent DNA ligase	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K01971,ko:K10747	ko03030,ko03410,ko03420,ko03430,ko03450,map03030,map03410,map03420,map03430,map03450	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
TLS1_k127_7630935_13	1123320.KB889681_gene2553	5.362e-46	181.0	COG1506@1|root,COG1680@1|root,COG1506@2|Bacteria,COG1680@2|Bacteria,2GMMM@201174|Actinobacteria	201174|Actinobacteria	EU	Peptidase S9 prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,PD40,Peptidase_S9
TLS1_k127_7648536_6	1288083.AUKR01000016_gene2680	6.932e-11	70.0	COG5552@1|root,COG5552@2|Bacteria,2IQKN@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized conserved protein (DUF2277)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2277
TLS1_k127_7648536_2	392499.Swit_1495	5.315e-97	339.0	COG0019@1|root,COG0019@2|Bacteria,1R4VG@1224|Proteobacteria,2U4JW@28211|Alphaproteobacteria,2K8KY@204457|Sphingomonadales	204457|Sphingomonadales	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	-	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
TLS1_k127_7648536_5	309801.trd_A0245	4.831e-29	130.0	COG3576@1|root,COG3576@2|Bacteria,2GBHG@200795|Chloroflexi,27YEI@189775|Thermomicrobia	189775|Thermomicrobia	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS1_k127_7648536_7	1122933.JNIY01000011_gene1218	7.424e-06	58.0	2CD8B@1|root,30VJG@2|Bacteria,2GY49@201174|Actinobacteria,4F310@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7648536_3	886293.Sinac_4483	3.619e-85	299.0	COG1526@1|root,COG1526@2|Bacteria,2IZ61@203682|Planctomycetes	203682|Planctomycetes	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
TLS1_k127_7648536_4	1122622.ATWJ01000012_gene992	4.049e-44	182.0	COG3896@1|root,COG3896@2|Bacteria,2IFF0@201174|Actinobacteria	201174|Actinobacteria	V	chloramphenicol	-	-	-	ko:K18554	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	CPT
TLS1_k127_7648536_1	446468.Ndas_4113	9.824e-136	442.0	COG3383@1|root,COG3383@2|Bacteria,2GKBP@201174|Actinobacteria,4EI2K@85012|Streptosporangiales	201174|Actinobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_6,Fer4_7,Molybdop_Fe4S4,NADH-G_4Fe-4S_3
TLS1_k127_7648536_0	1245475.ANAE01000107_gene661	8.923e-153	490.0	COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria,4EI2I@85012|Streptosporangiales	201174|Actinobacteria	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.17.1.9,1.6.5.3	ko:K00122,ko:K00335	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
TLS1_k127_7656402_0	1382356.JQMP01000001_gene1155	2.473e-199	637.0	COG1350@1|root,COG1350@2|Bacteria,2G5YY@200795|Chloroflexi,27XSD@189775|Thermomicrobia	189775|Thermomicrobia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS1_k127_7656402_10	2002.JOEQ01000004_gene2999	7.919e-45	171.0	COG2197@1|root,COG2197@2|Bacteria,2GKBX@201174|Actinobacteria,4EIFM@85012|Streptosporangiales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	ko:K02479	-	-	-	-	ko00000,ko02022	-	-	-	GerE,Response_reg
TLS1_k127_7656402_11	1128421.JAGA01000003_gene3431	1.835e-39	158.0	COG0287@1|root,COG0287@2|Bacteria,2NPZW@2323|unclassified Bacteria	2|Bacteria	E	Prephenate dehydrogenase	tyrA	-	1.3.1.12,1.3.1.43	ko:K00210,ko:K00220,ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025,M00040	R00732,R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDH
TLS1_k127_7656402_12	1122222.AXWR01000024_gene31	1.216e-31	138.0	COG4112@1|root,COG4112@2|Bacteria,1WMU8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS1_k127_7656402_5	309801.trd_1267	8.497e-72	268.0	COG1030@1|root,COG1030@2|Bacteria,2G6E2@200795|Chloroflexi,27XU8@189775|Thermomicrobia	189775|Thermomicrobia	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
TLS1_k127_7656402_3	1365176.N186_05705	4.858e-89	311.0	COG0330@1|root,arCOG01915@2157|Archaea,2XPQN@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
TLS1_k127_7656402_13	869210.Marky_1956	1.148e-18	100.0	COG1073@1|root,COG1073@2|Bacteria,1WKS0@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Prolyl oligopeptidase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4,Peptidase_S9
TLS1_k127_7656402_6	867845.KI911784_gene2853	1.621e-70	267.0	COG0745@1|root,COG4963@1|root,COG0745@2|Bacteria,COG4963@2|Bacteria,2G6CH@200795|Chloroflexi,37524@32061|Chloroflexia	32061|Chloroflexia	D	PFAM response regulator receiver	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,Response_reg
TLS1_k127_7656402_4	1194165.CAJF01000023_gene3158	1.755e-82	297.0	COG0739@1|root,COG0739@2|Bacteria,2I9IY@201174|Actinobacteria	201174|Actinobacteria	M	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS1_k127_7656402_2	266117.Rxyl_1395	1.844e-124	417.0	COG0606@1|root,COG0606@2|Bacteria,2GJIQ@201174|Actinobacteria,4CPKF@84995|Rubrobacteria	84995|Rubrobacteria	O	magnesium chelatase, ChlI subunit	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
TLS1_k127_7656402_9	243233.MCA2841	6.303e-53	204.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria,1XE4B@135618|Methylococcales	135618|Methylococcales	L	PFAM DNA recombination-mediator protein A	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
TLS1_k127_7656402_15	401053.AciPR4_2332	6.779e-06	59.0	COG2374@1|root,COG4932@1|root,COG5276@1|root,COG2374@2|Bacteria,COG4932@2|Bacteria,COG5276@2|Bacteria,3Y8ZJ@57723|Acidobacteria	57723|Acidobacteria	M	Protein of unknown function (DUF3494)	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF3494
TLS1_k127_7656402_14	479434.Sthe_1247	6.265e-06	54.0	2EMHG@1|root,33F64@2|Bacteria,2G7IC@200795|Chloroflexi,27YRF@189775|Thermomicrobia	189775|Thermomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7656402_1	743719.PaelaDRAFT_1592	1.132e-191	627.0	COG0550@1|root,COG0550@2|Bacteria,1TPUS@1239|Firmicutes,4HA6C@91061|Bacilli,26R4N@186822|Paenibacillaceae	91061|Bacilli	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
TLS1_k127_7656402_8	1121468.AUBR01000036_gene1298	5.047e-59	224.0	COG4974@1|root,COG4974@2|Bacteria,1TPQB@1239|Firmicutes,25C3N@186801|Clostridia,42G77@68295|Thermoanaerobacterales	186801|Clostridia	D	tyrosine recombinase XerC	xerC	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS1_k127_7656402_7	1382356.JQMP01000003_gene2578	7.736e-69	260.0	COG0728@1|root,COG0728@2|Bacteria,2G5MD@200795|Chloroflexi,27XGY@189775|Thermomicrobia	189775|Thermomicrobia	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
TLS1_k127_7701922_2	1231391.AMZF01000020_gene2010	4.649e-75	267.0	COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,1MUFT@1224|Proteobacteria	1224|Proteobacteria	E	(ABC) transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TLS1_k127_7701922_3	1500301.JQMF01000038_gene5910	5.231e-61	221.0	COG0559@1|root,COG0559@2|Bacteria,1P3FU@1224|Proteobacteria,2TT3V@28211|Alphaproteobacteria,4BCSD@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS1_k127_7701922_1	1231391.AMZF01000020_gene2008	1.682e-86	302.0	COG0683@1|root,COG0683@2|Bacteria,1NHBN@1224|Proteobacteria	1224|Proteobacteria	E	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS1_k127_7701922_5	1449976.KALB_801	2.322e-13	80.0	COG0457@1|root,COG0457@2|Bacteria,2I3MN@201174|Actinobacteria,4E4BA@85010|Pseudonocardiales	201174|Actinobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
TLS1_k127_7701922_0	311424.DhcVS_1200	2.632e-125	414.0	COG1488@1|root,COG1488@2|Bacteria,2G73F@200795|Chloroflexi,34CMV@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	QRPTase_C,QRPTase_N
TLS1_k127_7701922_4	743718.Isova_2798	1.72e-23	113.0	COG0308@1|root,COG0308@2|Bacteria,2ID1N@201174|Actinobacteria	201174|Actinobacteria	E	aminopeptidase N	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7721775_3	644966.Tmar_0493	2.92e-24	114.0	COG1215@1|root,COG1215@2|Bacteria,1UHQZ@1239|Firmicutes,25GH1@186801|Clostridia,3WDPU@538999|Clostridiales incertae sedis	186801|Clostridia	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
TLS1_k127_7721775_0	1259795.ARJK01000002_gene306	2.271e-100	338.0	COG1088@1|root,COG1088@2|Bacteria,1TPWM@1239|Firmicutes,247NE@186801|Clostridia	186801|Clostridia	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
TLS1_k127_7721775_6	525904.Tter_1038	1.078e-15	88.0	COG0392@1|root,COG0392@2|Bacteria,2NPGZ@2323|unclassified Bacteria	2|Bacteria	S	Lysylphosphatidylglycerol synthase TM region	mprF	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
TLS1_k127_7721775_1	931627.MycrhDRAFT_5098	5.028e-74	263.0	COG1215@1|root,COG1215@2|Bacteria,2IBMN@201174|Actinobacteria,239CX@1762|Mycobacteriaceae	201174|Actinobacteria	MQ	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_11
TLS1_k127_7721775_5	1122915.AUGY01000013_gene2877	1.192e-17	96.0	COG4346@1|root,COG5650@1|root,COG4346@2|Bacteria,COG5650@2|Bacteria,1TSHX@1239|Firmicutes,4ISHD@91061|Bacilli,26SCF@186822|Paenibacillaceae	91061|Bacilli	O	Glycosyl transferase	-	-	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	F5_F8_type_C,GT87,PMT,PMT_2,PMT_4TMC
TLS1_k127_7721775_4	479434.Sthe_1973	2.429e-18	98.0	COG2120@1|root,COG2120@2|Bacteria,2G6YU@200795|Chloroflexi,27YAS@189775|Thermomicrobia	189775|Thermomicrobia	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
TLS1_k127_7721775_2	1125863.JAFN01000001_gene2048	3.093e-56	209.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,42QSI@68525|delta/epsilon subdivisions,2WMNJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm-2	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
TLS1_k127_7721775_7	1052684.PPM_4781	4.291e-07	56.0	COG0477@1|root,COG0477@2|Bacteria,1UY4Q@1239|Firmicutes,4HD27@91061|Bacilli,26SG0@186822|Paenibacillaceae	91061|Bacilli	EGP	MFS transporter	snf4	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
TLS1_k127_7742839_8	767817.Desgi_0594	1.654e-74	258.0	COG0119@1|root,COG0119@2|Bacteria,1TP4Y@1239|Firmicutes,2485A@186801|Clostridia,260GB@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
TLS1_k127_7742839_3	1254432.SCE1572_22460	2.248e-141	456.0	COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,42MRS@68525|delta/epsilon subdivisions,2WJW8@28221|Deltaproteobacteria,2YU99@29|Myxococcales	28221|Deltaproteobacteria	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
TLS1_k127_7742839_13	479434.Sthe_1556	1.666e-48	187.0	COG0440@1|root,COG0440@2|Bacteria,2G6NW@200795|Chloroflexi,27Y6I@189775|Thermomicrobia	189775|Thermomicrobia	E	ACT domain	-	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_5,ALS_ss_C
TLS1_k127_7742839_2	316274.Haur_4449	2.621e-186	603.0	COG0028@1|root,COG0028@2|Bacteria,2G5Q7@200795|Chloroflexi,3751J@32061|Chloroflexia	32061|Chloroflexia	H	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS1_k127_7742839_7	368407.Memar_1784	1.993e-79	295.0	COG0370@1|root,arCOG00359@2157|Archaea,2XU46@28890|Euryarchaeota,2N913@224756|Methanomicrobia	224756|Methanomicrobia	P	Ferrous iron transport B domain protein	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
TLS1_k127_7742839_18	1304865.JAGF01000001_gene3519	1.83e-17	94.0	2DRIE@1|root,33BXS@2|Bacteria	2|Bacteria	S	Family of unknown function (DUF5317)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5317
TLS1_k127_7742839_4	351607.Acel_1905	7.099e-136	447.0	COG2203@1|root,COG5001@1|root,COG2203@2|Bacteria,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4ERVM@85013|Frankiales	201174|Actinobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GAF_2,GGDEF,HAMP,PAS
TLS1_k127_7742839_12	351607.Acel_1905	1.065e-50	197.0	COG2203@1|root,COG5001@1|root,COG2203@2|Bacteria,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4ERVM@85013|Frankiales	201174|Actinobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GAF_2,GGDEF,HAMP,PAS
TLS1_k127_7742839_0	383372.Rcas_1549	7.202e-219	698.0	COG0065@1|root,COG0065@2|Bacteria,2G68G@200795|Chloroflexi,3753P@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
TLS1_k127_7742839_9	1128421.JAGA01000002_gene1557	6.081e-69	243.0	COG0066@1|root,COG0066@2|Bacteria,2NRA0@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
TLS1_k127_7742839_20	28444.JODQ01000014_gene6736	1.606e-10	73.0	2E8P5@1|root,3330B@2|Bacteria,2GRP1@201174|Actinobacteria,4EPZJ@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7742839_11	981369.JQMJ01000003_gene7796	6.113e-52	200.0	COG0265@1|root,COG0265@2|Bacteria,2GJ92@201174|Actinobacteria,2NGJK@228398|Streptacidiphilus	201174|Actinobacteria	O	Colicin V production protein	cvpA	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009268,GO:0009405,GO:0009628,GO:0010447,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	Colicin_V,Trypsin_2
TLS1_k127_7742839_6	1121946.AUAX01000018_gene6998	8.4e-90	301.0	2CBRB@1|root,33SV2@2|Bacteria,2IJ64@201174|Actinobacteria,4DK0U@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7742839_10	1385520.N802_03425	6.036e-68	253.0	COG0664@1|root,COG0664@2|Bacteria,2I8MP@201174|Actinobacteria	201174|Actinobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,cNMP_binding
TLS1_k127_7742839_17	1229780.BN381_60087	4.55e-26	116.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	GGDEF,HTH_Crp_2,cNMP_binding
TLS1_k127_7742839_1	525904.Tter_0196	5.929e-206	661.0	COG0129@1|root,COG0129@2|Bacteria,2NNSM@2323|unclassified Bacteria	2|Bacteria	EG	Belongs to the IlvD Edd family	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
TLS1_k127_7742839_14	1078020.KEK_21889	5.01e-39	162.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,234RA@1762|Mycobacteriaceae	201174|Actinobacteria	C	F420-dependent oxidoreductase, Rv1855c family	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS1_k127_7742839_15	684949.ATTJ01000001_gene885	9.608e-29	130.0	COG0454@1|root,COG1670@1|root,COG0456@2|Bacteria,COG1670@2|Bacteria,1WMM3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS1_k127_7742839_5	1128421.JAGA01000002_gene1381	4.465e-91	323.0	COG0624@1|root,COG0624@2|Bacteria,2NQ4M@2323|unclassified Bacteria	2|Bacteria	E	Peptidase family M20/M25/M40	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28,Peptidase_M42
TLS1_k127_7742839_19	485913.Krac_4239	1.382e-10	72.0	COG1846@1|root,COG1846@2|Bacteria,2G9J7@200795|Chloroflexi	200795|Chloroflexi	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
TLS1_k127_7742839_16	1417296.U879_12060	3.286e-27	122.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,2TRTT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	malonyl CoA-acyl carrier protein transacylase	fabD	GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
TLS1_k127_7755064_1	264732.Moth_1750	2.068e-132	445.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1TP98@1239|Firmicutes,248BJ@186801|Clostridia,42F4K@68295|Thermoanaerobacterales	186801|Clostridia	J	phenylalanyl-tRNA synthetase (beta subunit)	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA-synt_2d,tRNA_bind
TLS1_k127_7755064_4	357808.RoseRS_4015	4.166e-06	56.0	2BY4B@1|root,2ZSE3@2|Bacteria,2GAFB@200795|Chloroflexi,375X8@32061|Chloroflexia	32061|Chloroflexia	S	Colicin V production protein	-	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
TLS1_k127_7755064_2	219305.MCAG_04932	6.149e-35	153.0	COG2094@1|root,COG2094@2|Bacteria,2GNW1@201174|Actinobacteria,4DD25@85008|Micromonosporales	201174|Actinobacteria	L	Belongs to the DNA glycosylase MPG family	-	-	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
TLS1_k127_7755064_0	292459.STH1115	4.352e-161	538.0	COG1193@1|root,COG1193@2|Bacteria,1TP5W@1239|Firmicutes,248YK@186801|Clostridia	186801|Clostridia	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
TLS1_k127_7755064_3	383372.Rcas_3834	3.083e-16	88.0	COG0744@1|root,COG0744@2|Bacteria,2G5ZG@200795|Chloroflexi,374XI@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase, family 51	-	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
TLS1_k127_7756302_15	290397.Adeh_0710	2.785e-26	120.0	COG1633@1|root,COG1814@1|root,COG1633@2|Bacteria,COG1814@2|Bacteria,1MUZE@1224|Proteobacteria,42UMC@68525|delta/epsilon subdivisions,2WQJQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
TLS1_k127_7756302_18	1120949.KB903336_gene9641	1.534e-21	102.0	2BWWR@1|root,2ZG0F@2|Bacteria,2IJ2X@201174|Actinobacteria,4DDGM@85008|Micromonosporales	201174|Actinobacteria	S	pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS1_k127_7756302_2	479435.Kfla_6943	2.14e-159	519.0	COG1167@1|root,COG1167@2|Bacteria,2GJ5P@201174|Actinobacteria,4DPK2@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	ko:K00375	-	-	-	-	ko00000,ko03000	-	-	-	Aminotran_1_2,GntR
TLS1_k127_7756302_0	292459.STH3193	1.324e-261	825.0	COG2987@1|root,COG2987@2|Bacteria,1TPZ9@1239|Firmicutes,247YS@186801|Clostridia	186801|Clostridia	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
TLS1_k127_7756302_8	383372.Rcas_4344	1.763e-72	255.0	COG0745@1|root,COG0745@2|Bacteria,2G5ND@200795|Chloroflexi,376TC@32061|Chloroflexia	32061|Chloroflexia	K	Two component transcriptional regulator, winged helix family	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS1_k127_7756302_12	644282.Deba_1067	4.268e-42	167.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,42NB5@68525|delta/epsilon subdivisions,2WJGX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
TLS1_k127_7756302_3	1128421.JAGA01000002_gene119	5.829e-146	475.0	COG0334@1|root,COG0334@2|Bacteria,2NNRJ@2323|unclassified Bacteria	2|Bacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
TLS1_k127_7756302_11	935840.JAEQ01000002_gene3279	6.401e-46	168.0	COG0640@1|root,COG0640@2|Bacteria,1RH5P@1224|Proteobacteria,2U960@28211|Alphaproteobacteria,43KDS@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS1_k127_7756302_14	1121090.KB894685_gene3407	2.448e-32	134.0	COG3832@1|root,COG3832@2|Bacteria,1VSFF@1239|Firmicutes,4HTMI@91061|Bacilli,1ZIPI@1386|Bacillus	91061|Bacilli	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS1_k127_7756302_6	1089545.KB913037_gene8413	2.945e-78	269.0	COG2197@1|root,COG2197@2|Bacteria,2GYMP@201174|Actinobacteria,4E2HE@85010|Pseudonocardiales	201174|Actinobacteria	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS1_k127_7756302_13	469383.Cwoe_3719	1.374e-33	132.0	COG2197@1|root,COG2197@2|Bacteria,2I5RT@201174|Actinobacteria	201174|Actinobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS1_k127_7756302_9	479434.Sthe_3261	6.308e-52	207.0	COG2334@1|root,COG2334@2|Bacteria,2G71B@200795|Chloroflexi	200795|Chloroflexi	S	PFAM aminoglycoside phosphotransferase	-	-	-	ko:K18844	-	-	-	-	ko00000,ko01504	-	-	-	APH
TLS1_k127_7756302_17	1304878.AUGD01000006_gene6743	4.097e-23	109.0	COG3247@1|root,COG3247@2|Bacteria,1RFIH@1224|Proteobacteria,2U5WE@28211|Alphaproteobacteria,3JTES@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
TLS1_k127_7756302_20	1463885.KL578510_gene9600	0.0004719	48.0	COG2220@1|root,COG2220@2|Bacteria	2|Bacteria	S	N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TLS1_k127_7756302_19	1283299.AUKG01000002_gene5008	5.878e-16	83.0	COG2220@1|root,COG2220@2|Bacteria,2GN98@201174|Actinobacteria,4CSJ8@84995|Rubrobacteria	84995|Rubrobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TLS1_k127_7756302_7	1122138.AQUZ01000030_gene4646	6.729e-75	263.0	COG0583@1|root,COG0583@2|Bacteria,2GJFG@201174|Actinobacteria,4DW8J@85009|Propionibacteriales	201174|Actinobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS1_k127_7756302_1	1536769.P40081_26720	4.739e-162	524.0	COG0366@1|root,COG0366@2|Bacteria,1TR93@1239|Firmicutes,4HEKC@91061|Bacilli,26TSJ@186822|Paenibacillaceae	91061|Bacilli	G	Alpha amylase, catalytic domain	-	-	2.4.1.329	ko:K21350	-	-	-	-	ko00000,ko01000	-	GH13	-	Alpha-amylase
TLS1_k127_7756302_4	1185652.USDA257_c04170	1.153e-136	464.0	COG3408@1|root,COG3408@2|Bacteria,1MUYU@1224|Proteobacteria,2TQK2@28211|Alphaproteobacteria,4B9N1@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Protein involved in amylo-alpha-1,6-glucosidase activity and glycogen biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N_bis
TLS1_k127_7756302_5	1500894.JQNN01000001_gene4294	8.583e-90	309.0	COG4221@1|root,COG4221@2|Bacteria,1MUU6@1224|Proteobacteria,2VM6H@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS1_k127_7756302_10	1089547.KB913013_gene1930	3.414e-47	179.0	COG4244@1|root,COG4244@2|Bacteria,4NPHV@976|Bacteroidetes,47PWW@768503|Cytophagia	976|Bacteroidetes	S	Predicted membrane protein (DUF2231)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231
TLS1_k127_7756302_16	768710.DesyoDRAFT_2148	3.655e-24	108.0	COG0243@1|root,COG0243@2|Bacteria,1UJ0U@1239|Firmicutes,24DJH@186801|Clostridia,263DS@186807|Peptococcaceae	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
TLS1_k127_7768322_9	1382356.JQMP01000003_gene2145	3.704e-18	97.0	COG1595@1|root,COG1595@2|Bacteria,2G6T5@200795|Chloroflexi,27YAG@189775|Thermomicrobia	189775|Thermomicrobia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS1_k127_7768322_5	404589.Anae109_0138	1.342e-43	173.0	COG1085@1|root,COG1085@2|Bacteria,1MU3E@1224|Proteobacteria,42MP4@68525|delta/epsilon subdivisions,2WKT8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM galactose-1-phosphate uridylyltransferase	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4921,GalP_UDP_tr_C,GalP_UDP_transf
TLS1_k127_7768322_4	324602.Caur_2835	1.158e-50	189.0	COG0321@1|root,COG0321@2|Bacteria,2G8KT@200795|Chloroflexi,375KR@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
TLS1_k127_7768322_3	1123024.AUII01000006_gene4635	1.627e-75	265.0	2DN8B@1|root,32W2U@2|Bacteria,2ISPU@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7768322_0	1123024.AUII01000006_gene4636	0.0	1284.0	COG3696@1|root,COG3696@2|Bacteria,2I53X@201174|Actinobacteria,4EE9U@85010|Pseudonocardiales	201174|Actinobacteria	P	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
TLS1_k127_7768322_8	1150398.JIBJ01000004_gene2790	3.141e-21	109.0	COG0845@1|root,COG0845@2|Bacteria,2I53W@201174|Actinobacteria	201174|Actinobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7768322_1	1123024.AUII01000006_gene4638	1.244e-282	902.0	COG3696@1|root,COG3696@2|Bacteria,2H303@201174|Actinobacteria,4EF0N@85010|Pseudonocardiales	201174|Actinobacteria	P	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
TLS1_k127_7768322_7	469383.Cwoe_1232	1.498e-29	131.0	COG4585@1|root,COG4585@2|Bacteria,2HDZV@201174|Actinobacteria,4CR31@84995|Rubrobacteria	84995|Rubrobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07675	ko02020,map02020	M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA_3
TLS1_k127_7768322_6	58344.JOEL01000002_gene1763	5.548e-43	168.0	COG2197@1|root,COG2197@2|Bacteria,2GJHH@201174|Actinobacteria	201174|Actinobacteria	T	Response regulator receiver	-	-	-	ko:K07696	ko02020,map02020	M00483	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
TLS1_k127_7768322_2	1128421.JAGA01000004_gene2558	5.038e-122	404.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS1_k127_7836058_21	446470.Snas_4128	5.218e-43	167.0	COG1622@1|root,COG1622@2|Bacteria,2GNXA@201174|Actinobacteria,4EXR2@85014|Glycomycetales	201174|Actinobacteria	C	Cytochrome C oxidase subunit II, periplasmic domain	ctaC	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0040007,GO:0042773,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044281,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0051704,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM
TLS1_k127_7836058_3	1122611.KB903941_gene2083	2.244e-213	690.0	COG0843@1|root,COG0843@2|Bacteria,2GJHX@201174|Actinobacteria,4EFHC@85012|Streptosporangiales	201174|Actinobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0040007,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
TLS1_k127_7836058_34	1042376.AFPK01000068_gene476	2.018e-06	52.0	2EHBZ@1|root,33B3U@2|Bacteria,4NZK3@976|Bacteroidetes,1I71Q@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7836058_10	479434.Sthe_1829	1.999e-103	366.0	COG0465@1|root,COG0465@2|Bacteria,2G5J3@200795|Chloroflexi,27XT6@189775|Thermomicrobia	200795|Chloroflexi	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	AAA,Peptidase_M41
TLS1_k127_7836058_7	471852.Tcur_4278	1.568e-123	407.0	COG1131@1|root,COG1131@2|Bacteria,2GKWB@201174|Actinobacteria,4EIF9@85012|Streptosporangiales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS1_k127_7836058_22	1894.JOER01000016_gene5540	7.972e-36	154.0	COG1277@1|root,COG1277@2|Bacteria,2GKKP@201174|Actinobacteria	201174|Actinobacteria	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
TLS1_k127_7836058_8	390989.JOEG01000003_gene4457	9.377e-115	393.0	COG1131@1|root,COG1131@2|Bacteria,2GK1W@201174|Actinobacteria,4D8V1@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS1_k127_7836058_23	134676.ACPL_920	1.225e-33	147.0	COG1277@1|root,COG1277@2|Bacteria,2GK3E@201174|Actinobacteria,4D9FS@85008|Micromonosporales	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_4
TLS1_k127_7836058_18	479434.Sthe_1818	1.544e-63	231.0	COG2042@1|root,COG3376@2|Bacteria	2|Bacteria	K	Belongs to the NiCoT transporter (TC 2.A.52) family	-	-	-	ko:K07241	-	-	-	-	ko00000,ko02000	2.A.52.1	-	-	NicO
TLS1_k127_7836058_26	298653.Franean1_6149	1.115e-22	113.0	COG0735@1|root,COG0735@2|Bacteria,2IFHB@201174|Actinobacteria,4ESU5@85013|Frankiales	201174|Actinobacteria	P	Belongs to the Fur family	-	-	-	ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
TLS1_k127_7836058_12	357808.RoseRS_1555	1.77e-99	333.0	COG0623@1|root,COG0623@2|Bacteria,2G6ED@200795|Chloroflexi,375AJ@32061|Chloroflexia	32061|Chloroflexia	I	Enoyl- acyl-carrier-protein reductase NADH	-	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS1_k127_7836058_5	446462.Amir_3077	7.777e-167	543.0	COG1012@1|root,COG1012@2|Bacteria,2HF1C@201174|Actinobacteria,4EA29@85010|Pseudonocardiales	201174|Actinobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
TLS1_k127_7836058_33	479434.Sthe_2634	2.863e-08	65.0	COG3794@1|root,COG3794@2|Bacteria,2G7GX@200795|Chloroflexi,27YQJ@189775|Thermomicrobia	189775|Thermomicrobia	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
TLS1_k127_7836058_32	1337093.MBE-LCI_3386	5.009e-09	66.0	COG3794@1|root,COG3794@2|Bacteria,1RI9G@1224|Proteobacteria,2U7KA@28211|Alphaproteobacteria,2PA03@245186|Loktanella	28211|Alphaproteobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
TLS1_k127_7836058_4	446462.Amir_3076	5.928e-175	559.0	COG0160@1|root,COG0160@2|Bacteria,2GIS9@201174|Actinobacteria,4DY9R@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,4.1.1.64	ko:K00596,ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS1_k127_7836058_9	405948.SACE_4008	3.439e-112	381.0	COG1788@1|root,COG1788@2|Bacteria,2GK61@201174|Actinobacteria,4DX73@85010|Pseudonocardiales	201174|Actinobacteria	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
TLS1_k127_7836058_15	926569.ANT_02010	2.41e-80	282.0	COG2057@1|root,COG2057@2|Bacteria,2G6MS@200795|Chloroflexi	200795|Chloroflexi	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
TLS1_k127_7836058_31	1115515.EV102420_10_00370	1.018e-12	80.0	COG2261@1|root,COG2261@2|Bacteria,1N72W@1224|Proteobacteria,1S8YP@1236|Gammaproteobacteria,3XQ0Y@561|Escherichia	1236|Gammaproteobacteria	S	Transglycosylase associated protein	ymgE	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
TLS1_k127_7836058_16	749927.AMED_6574	8.365e-69	265.0	COG0282@1|root,COG0282@2|Bacteria,2GJAW@201174|Actinobacteria,4DYVV@85010|Pseudonocardiales	201174|Actinobacteria	C	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	-	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
TLS1_k127_7836058_0	644283.Micau_1696	9.204e-285	896.0	COG3957@1|root,COG3957@2|Bacteria,2GN27@201174|Actinobacteria,4D8DJ@85008|Micromonosporales	201174|Actinobacteria	G	Phosphoketolase	xfp	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
TLS1_k127_7836058_11	1128421.JAGA01000001_gene2386	9.821e-100	341.0	COG2132@1|root,COG2132@2|Bacteria,2NPD2@2323|unclassified Bacteria	2|Bacteria	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K22348	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1,DUF4396
TLS1_k127_7836058_30	1464048.JNZS01000001_gene137	3.05e-14	83.0	2E1T4@1|root,32X2Z@2|Bacteria,2H4V9@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7836058_20	1246995.AFR_24710	1.08e-47	177.0	COG1595@1|root,COG1595@2|Bacteria,2HGII@201174|Actinobacteria,4DDNQ@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS1_k127_7836058_25	1300345.LF41_48	8.208e-24	120.0	COG0028@1|root,COG1520@1|root,COG3391@1|root,COG3693@1|root,COG0028@2|Bacteria,COG1520@2|Bacteria,COG3391@2|Bacteria,COG3693@2|Bacteria,1QYUP@1224|Proteobacteria	1224|Proteobacteria	EH	HYR domain	-	-	-	-	-	-	-	-	-	-	-	-	HYR
TLS1_k127_7836058_2	382464.ABSI01000013_gene1571	5.593e-232	782.0	COG1572@1|root,COG3210@1|root,COG3386@1|root,COG4257@1|root,COG5373@1|root,COG1572@2|Bacteria,COG3210@2|Bacteria,COG3386@2|Bacteria,COG4257@2|Bacteria,COG5373@2|Bacteria	2|Bacteria	KLT	membrane	-	-	-	ko:K13277,ko:K15125,ko:K15539	ko02024,ko05133,map02024,map05133	-	-	-	ko00000,ko00001,ko00536,ko01000,ko01002,ko03110	-	-	-	DUF5011
TLS1_k127_7836058_35	1123322.KB904658_gene1310	2.539e-05	59.0	COG2911@1|root,COG2911@2|Bacteria,2IFIC@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF642)	-	-	-	-	-	-	-	-	-	-	-	-	DUF642
TLS1_k127_7836058_1	382464.ABSI01000013_gene1570	2.43e-260	864.0	COG2114@1|root,COG3899@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,COG3903@2|Bacteria,46U27@74201|Verrucomicrobia	74201|Verrucomicrobia	T	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc
TLS1_k127_7836058_13	1125863.JAFN01000001_gene1858	1.445e-96	359.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,42MFC@68525|delta/epsilon subdivisions,2WINR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.55,2.6.1.77	ko:K03851,ko:K15372	ko00410,ko00430,ko01100,map00410,map00430,map01100	-	R00908,R01684,R05652	RC00006,RC00008,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
TLS1_k127_7836058_6	479434.Sthe_0188	8.027e-156	527.0	COG2409@1|root,COG2409@2|Bacteria,2G6XZ@200795|Chloroflexi,27XX9@189775|Thermomicrobia	189775|Thermomicrobia	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
TLS1_k127_7836058_27	1246995.AFR_39605	1.289e-21	103.0	COG1309@1|root,COG1309@2|Bacteria,2GZ1Y@201174|Actinobacteria,4DDXG@85008|Micromonosporales	201174|Actinobacteria	K	BetI-type transcriptional repressor, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
TLS1_k127_7836058_17	330084.JNYZ01000015_gene5929	7.904e-66	248.0	COG1735@1|root,COG1735@2|Bacteria,2GMZ6@201174|Actinobacteria,4E2QP@85010|Pseudonocardiales	201174|Actinobacteria	S	Phosphotriesterase family	-	-	-	ko:K07048	-	-	-	-	ko00000	-	-	-	PTE
TLS1_k127_7836058_24	266117.Rxyl_0142	1.295e-29	138.0	COG1764@1|root,COG1764@2|Bacteria,2IFFB@201174|Actinobacteria,4CQIW@84995|Rubrobacteria	84995|Rubrobacteria	O	OsmC-like protein	-	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
TLS1_k127_7836058_28	1382356.JQMP01000003_gene1531	8.236e-18	94.0	COG2340@1|root,COG5479@1|root,COG2340@2|Bacteria,COG5479@2|Bacteria,2GBCS@200795|Chloroflexi,27YT2@189775|Thermomicrobia	189775|Thermomicrobia	M	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP
TLS1_k127_7836058_14	105422.BBPM01000097_gene5229	4.625e-95	327.0	COG3214@1|root,COG3214@2|Bacteria,2GJM7@201174|Actinobacteria,2NH21@228398|Streptacidiphilus	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
TLS1_k127_7836058_19	365046.Rta_23850	2.108e-51	186.0	COG4119@1|root,COG4119@2|Bacteria,1RHCE@1224|Proteobacteria,2VV6B@28216|Betaproteobacteria	28216|Betaproteobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS1_k127_7840795_23	596327.PORUE0001_0447	1.481e-24	119.0	COG4589@1|root,COG4589@2|Bacteria,4NIPM@976|Bacteroidetes,2FMKC@200643|Bacteroidia,22XR3@171551|Porphyromonadaceae	976|Bacteroidetes	S	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
TLS1_k127_7840795_27	67267.JNXT01000060_gene7659	2.155e-14	81.0	COG0558@1|root,COG0558@2|Bacteria,2I9CP@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS1_k127_7840795_19	926569.ANT_06210	1.845e-40	171.0	COG2720@1|root,COG2720@2|Bacteria,2G67R@200795|Chloroflexi	200795|Chloroflexi	V	PFAM VanW family protein	-	-	-	-	-	-	-	-	-	-	-	-	G5,PG_binding_4,VanW
TLS1_k127_7840795_12	1304865.JAGF01000001_gene3323	6.782e-58	209.0	28PN6@1|root,2ZCB1@2|Bacteria,2INN5@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
TLS1_k127_7840795_24	477641.MODMU_5397	1.64e-24	107.0	COG4308@1|root,COG4308@2|Bacteria,2IJ55@201174|Actinobacteria	201174|Actinobacteria	Q	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
TLS1_k127_7840795_31	1118058.CAGY01000001_gene149	2.565e-09	64.0	2ASDQ@1|root,31HT6@2|Bacteria,2HMBW@201174|Actinobacteria,4D6R3@85005|Actinomycetales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7840795_35	1304875.JAFZ01000004_gene476	0.0005682	49.0	2DD8T@1|root,2ZH33@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7840795_13	28444.JODQ01000013_gene2933	1.213e-57	207.0	COG4430@1|root,COG4430@2|Bacteria,2II0D@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
TLS1_k127_7840795_5	42256.RradSPS_0124	5.546e-102	342.0	COG0501@1|root,COG0501@2|Bacteria,2GMJF@201174|Actinobacteria,4CQF1@84995|Rubrobacteria	84995|Rubrobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
TLS1_k127_7840795_18	42256.RradSPS_0123	2.303e-49	183.0	COG1704@1|root,COG1704@2|Bacteria,2GPS4@201174|Actinobacteria,4CQJT@84995|Rubrobacteria	84995|Rubrobacteria	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
TLS1_k127_7840795_32	926550.CLDAP_30620	5.093e-08	66.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Inhibitor_I9,Peptidase_S8,TIG
TLS1_k127_7840795_34	1379698.RBG1_1C00001G0627	7.086e-07	58.0	COG1595@1|root,COG1595@2|Bacteria,2NQ4E@2323|unclassified Bacteria	2|Bacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS1_k127_7840795_11	1521187.JPIM01000035_gene3387	9.808e-60	230.0	COG0747@1|root,COG0747@2|Bacteria,2G5NC@200795|Chloroflexi,375DK@32061|Chloroflexia	32061|Chloroflexia	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS1_k127_7840795_33	926550.CLDAP_38540	3.616e-07	55.0	COG1314@1|root,COG1314@2|Bacteria	2|Bacteria	U	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	secG	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
TLS1_k127_7840795_4	1128421.JAGA01000002_gene1871	2.116e-147	502.0	COG0696@1|root,COG0696@2|Bacteria,2NP1Y@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030145,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0043937,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046537,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0050789,GO:0050793,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	iECSE_1348.ECSE_3895,iJN678.yibO,iJN746.PP_5056	Metalloenzyme,Phosphodiest,iPGM_N
TLS1_k127_7840795_14	926550.CLDAP_03710	3.547e-56	208.0	COG0149@1|root,COG0149@2|Bacteria,2G69W@200795|Chloroflexi	200795|Chloroflexi	F	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
TLS1_k127_7840795_25	864563.HMPREF9166_2229	1.918e-23	110.0	COG1481@1|root,COG1481@2|Bacteria,1TP2X@1239|Firmicutes,4H222@909932|Negativicutes	909932|Negativicutes	K	May be required for sporulation	whiA	-	-	ko:K09762	-	-	-	-	ko00000	-	-	-	HTH_WhiA,LAGLIDADG_WhiA,WhiA_N
TLS1_k127_7840795_6	1382356.JQMP01000003_gene2504	2.964e-97	335.0	COG0391@1|root,COG0391@2|Bacteria,2G5MJ@200795|Chloroflexi,27XU0@189775|Thermomicrobia	189775|Thermomicrobia	S	Required for morphogenesis under gluconeogenic growth conditions	-	-	-	-	-	-	-	-	-	-	-	-	UPF0052
TLS1_k127_7840795_9	635013.TherJR_2719	7.925e-74	259.0	COG1660@1|root,COG1660@2|Bacteria,1TPS4@1239|Firmicutes,248KQ@186801|Clostridia,2616Z@186807|Peptococcaceae	186801|Clostridia	S	Displays ATPase and GTPase activities	yvcJ	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
TLS1_k127_7840795_20	1382306.JNIM01000001_gene3747	1.698e-38	154.0	COG0805@1|root,COG0805@2|Bacteria,2G6SP@200795|Chloroflexi	200795|Chloroflexi	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
TLS1_k127_7840795_28	1123250.KB908383_gene1401	2.988e-12	70.0	COG1826@1|root,COG1826@2|Bacteria,1VFP2@1239|Firmicutes,4H5RV@909932|Negativicutes	909932|Negativicutes	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
TLS1_k127_7840795_16	383372.Rcas_4349	1.953e-51	203.0	COG0284@1|root,COG0284@2|Bacteria,2G692@200795|Chloroflexi,3771N@32061|Chloroflexia	32061|Chloroflexia	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
TLS1_k127_7840795_30	479434.Sthe_1223	1.219e-10	76.0	COG0823@1|root,COG0823@2|Bacteria,2G8Z9@200795|Chloroflexi,27XTF@189775|Thermomicrobia	189775|Thermomicrobia	U	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
TLS1_k127_7840795_8	1345697.M493_13375	4.801e-89	316.0	COG0608@1|root,COG4199@1|root,COG0608@2|Bacteria,COG4199@2|Bacteria,1TPXE@1239|Firmicutes,4H9UP@91061|Bacilli,1WE5V@129337|Geobacillus	91061|Bacilli	L	Single-strand DNA-specific exonuclease, C terminal domain	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1,ssDNA-exonuc_C
TLS1_k127_7840795_10	309801.trd_0649	2.713e-64	235.0	COG0341@1|root,COG0341@2|Bacteria,2G696@200795|Chloroflexi,27Y1D@189775|Thermomicrobia	189775|Thermomicrobia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
TLS1_k127_7840795_7	525904.Tter_0079	2.352e-94	326.0	COG0342@1|root,COG0342@2|Bacteria,2NNNU@2323|unclassified Bacteria	2|Bacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	6.3.2.2	ko:K01919,ko:K03072,ko:K12257	ko00270,ko00480,ko01100,ko02024,ko03060,ko03070,map00270,map00480,map01100,map02024,map03060,map03070	M00118,M00335	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	GshA,SecD_SecF,Sec_GG
TLS1_k127_7840795_17	1172180.KB911786_gene91	4.311e-50	195.0	COG5646@1|root,COG5646@2|Bacteria,2IINN@201174|Actinobacteria	201174|Actinobacteria	S	InterPro IPR014922	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
TLS1_k127_7840795_1	760568.Desku_3306	3.228e-183	592.0	COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,260I5@186807|Peptococcaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
TLS1_k127_7840795_22	867845.KI911784_gene1260	1.127e-25	123.0	COG0823@1|root,COG1520@1|root,COG0823@2|Bacteria,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	ko:K03641,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.C.1.2	-	-	DUF11,HYR,PD40,PQQ_2,VCBS
TLS1_k127_7840795_2	1300345.LF41_48	7.109e-181	600.0	COG0028@1|root,COG1520@1|root,COG3391@1|root,COG3693@1|root,COG0028@2|Bacteria,COG1520@2|Bacteria,COG3391@2|Bacteria,COG3693@2|Bacteria,1QYUP@1224|Proteobacteria	1224|Proteobacteria	EH	HYR domain	-	-	-	-	-	-	-	-	-	-	-	-	HYR
TLS1_k127_7840795_0	1385519.N801_03480	1.084e-196	638.0	COG0737@1|root,COG0737@2|Bacteria,2GKC3@201174|Actinobacteria,4FEPR@85021|Intrasporangiaceae	201174|Actinobacteria	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.5	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
TLS1_k127_7840795_3	710696.Intca_0183	6.474e-171	548.0	COG4222@1|root,COG4222@2|Bacteria,2GJN8@201174|Actinobacteria,4FF9Q@85021|Intrasporangiaceae	201174|Actinobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS1_k127_7840795_15	867903.ThesuDRAFT_02284	6.057e-54	210.0	COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,3WCQQ@538999|Clostridiales incertae sedis	186801|Clostridia	L	UvrD/REP helicase N-terminal domain	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
TLS1_k127_7840795_21	309803.CTN_1608	2.174e-26	116.0	COG1670@1|root,COG1670@2|Bacteria,2GCW5@200918|Thermotogae	200918|Thermotogae	J	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS1_k127_788794_2	1128421.JAGA01000002_gene351	2.361e-101	337.0	COG0414@1|root,COG0414@2|Bacteria,2NP0J@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
TLS1_k127_788794_3	324602.Caur_2208	2.44e-95	321.0	COG0413@1|root,COG0413@2|Bacteria,2G5TQ@200795|Chloroflexi,3755C@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
TLS1_k127_788794_4	861299.J421_3319	1.29e-92	332.0	COG0452@1|root,COG0452@2|Bacteria,1ZV19@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
TLS1_k127_788794_6	1120936.KB907215_gene4226	2.117e-56	207.0	COG1521@1|root,COG1521@2|Bacteria,2GMRQ@201174|Actinobacteria,4EH40@85012|Streptosporangiales	201174|Actinobacteria	K	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
TLS1_k127_788794_7	1068978.AMETH_5925	6.364e-48	183.0	2E9GJ@1|root,333PP@2|Bacteria,2HC60@201174|Actinobacteria	201174|Actinobacteria	S	Lysyl oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Lysyl_oxidase
TLS1_k127_788794_1	1123368.AUIS01000006_gene569	3.701e-110	372.0	COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,1RNGN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	glucose sorbosone	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,Cytochrome_CBB3,GSDH,PSCyt3,PSD3,PSD4,PSD5,SGL
TLS1_k127_788794_8	46234.ANA_C12039	1.273e-05	54.0	2AY0A@1|root,31Q1V@2|Bacteria,1G5XA@1117|Cyanobacteria,1HND8@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_788794_0	1385520.N802_06390	2.379e-117	394.0	COG2252@1|root,COG2252@2|Bacteria,2GKYD@201174|Actinobacteria,4FE4H@85021|Intrasporangiaceae	201174|Actinobacteria	S	permease	pbuG	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
TLS1_k127_788794_5	243164.DET1429	5.842e-91	317.0	COG0612@1|root,COG0612@2|Bacteria,2G672@200795|Chloroflexi,34CMZ@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS1_k127_7899866_14	440512.C211_21577	2.143e-37	155.0	COG1295@1|root,COG1295@2|Bacteria,1MXQA@1224|Proteobacteria,1RP8E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS1_k127_7899866_9	504728.K649_04355	5.273e-53	191.0	COG0454@1|root,COG0456@2|Bacteria,1WND2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	FR47-like protein	-	-	-	ko:K03829	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
TLS1_k127_7899866_8	1283299.AUKG01000002_gene5008	7.722e-59	214.0	COG2220@1|root,COG2220@2|Bacteria,2GN98@201174|Actinobacteria,4CSJ8@84995|Rubrobacteria	84995|Rubrobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TLS1_k127_7899866_22	1394178.AWOO02000033_gene8495	7.035e-15	87.0	2ASGX@1|root,31HX4@2|Bacteria,2IJVE@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7899866_15	1206737.BAGF01000023_gene1145	3.498e-30	135.0	COG0748@1|root,COG0748@2|Bacteria,2I2TX@201174|Actinobacteria,4G9KY@85025|Nocardiaceae	201174|Actinobacteria	P	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red,Hemerythrin
TLS1_k127_7899866_16	1214101.BN159_0442	5.322e-30	124.0	COG1359@1|root,COG1359@2|Bacteria,2GT9F@201174|Actinobacteria	201174|Actinobacteria	S	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7899866_3	525904.Tter_2265	5.912e-118	409.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS1_k127_7899866_10	1128421.JAGA01000001_gene2184	1.633e-52	198.0	COG1082@1|root,COG1082@2|Bacteria,2NQSY@2323|unclassified Bacteria	2|Bacteria	G	Xylose isomerase-like TIM barrel	iolE	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS1_k127_7899866_20	1169161.KB897715_gene5702	2.061e-15	85.0	COG4832@1|root,COG4832@2|Bacteria,2GN4K@201174|Actinobacteria	201174|Actinobacteria	K	GyrI-like small molecule binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
TLS1_k127_7899866_18	1459636.NTE_00536	4.708e-25	109.0	COG0346@1|root,arCOG02708@2157|Archaea	2157|Archaea	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
TLS1_k127_7899866_4	1179773.BN6_22990	6.844e-106	355.0	COG0030@1|root,COG0030@2|Bacteria,2GIZ8@201174|Actinobacteria,4DYTH@85010|Pseudonocardiales	201174|Actinobacteria	J	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS1_k127_7899866_12	395019.Bmul_4571	3.869e-41	160.0	COG3554@1|root,COG3554@2|Bacteria,1N2WV@1224|Proteobacteria,2VXEY@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Putative glycolipid-binding	-	-	-	ko:K09957	-	-	-	-	ko00000	-	-	-	Glycolipid_bind
TLS1_k127_7899866_5	485913.Krac_0278	3.849e-86	296.0	COG0604@1|root,COG0604@2|Bacteria,2G84Q@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
TLS1_k127_7899866_13	29540.C481_20031	2.351e-39	155.0	COG3358@1|root,arCOG04570@2157|Archaea,2XX3J@28890|Euryarchaeota,23VM5@183963|Halobacteria	183963|Halobacteria	S	Protein of unknown function (DUF1684)	-	-	-	ko:K09164	-	-	-	-	ko00000	-	-	-	DUF1684
TLS1_k127_7899866_11	1380347.JNII01000006_gene1824	6.989e-47	189.0	COG4585@1|root,COG4585@2|Bacteria,2HDZV@201174|Actinobacteria,4EX5G@85013|Frankiales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS1_k127_7899866_6	258533.BN977_03376	1.523e-71	254.0	COG2197@1|root,COG2197@2|Bacteria,2GJRY@201174|Actinobacteria,2352X@1762|Mycobacteriaceae	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS1_k127_7899866_24	1869.MB27_22425	4.217e-07	59.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria,4DB1I@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS1_k127_7899866_21	485913.Krac_10933	3.212e-15	89.0	COG0664@1|root,COG0664@2|Bacteria,2G92E@200795|Chloroflexi	200795|Chloroflexi	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
TLS1_k127_7899866_2	1298863.AUEP01000002_gene1370	1.503e-139	464.0	COG0477@1|root,COG2814@2|Bacteria,2GKHG@201174|Actinobacteria,4DPT4@85009|Propionibacteriales	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
TLS1_k127_7899866_7	1082933.MEA186_09605	3.602e-69	237.0	COG2346@1|root,COG2346@2|Bacteria,1Q38S@1224|Proteobacteria,2UJT6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Truncated hemoglobins	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
TLS1_k127_7899866_0	1313172.YM304_27180	5.027e-276	857.0	COG0488@1|root,COG0488@2|Bacteria,2GKBQ@201174|Actinobacteria,4CNI9@84992|Acidimicrobiia	84992|Acidimicrobiia	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
TLS1_k127_7899866_17	709986.Deima_1142	2.686e-25	109.0	2C4JB@1|root,337ZU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7899866_1	1283299.AUKG01000001_gene3557	4.084e-190	615.0	COG0160@1|root,COG2334@1|root,COG0160@2|Bacteria,COG2334@2|Bacteria,2GKVH@201174|Actinobacteria,4CRRI@84995|Rubrobacteria	84995|Rubrobacteria	E	Aminotransferase class-III	-	-	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	APH,Aminotran_3
TLS1_k127_7904174_2	1385520.N802_07670	3.222e-32	134.0	2EA9M@1|root,334E1@2|Bacteria,2I49S@201174|Actinobacteria	201174|Actinobacteria	S	CHRD domain	-	-	-	-	-	-	-	-	-	-	-	-	CHRD
TLS1_k127_7904174_3	1120949.KB903356_gene8572	8.309e-24	115.0	COG0784@1|root,COG0784@2|Bacteria,2I40J@201174|Actinobacteria,4DMH8@85008|Micromonosporales	201174|Actinobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS1_k127_7904174_0	35754.JNYJ01000017_gene6270	6.217e-172	572.0	COG0642@1|root,COG2205@2|Bacteria,2I2M2@201174|Actinobacteria,4DAYW@85008|Micromonosporales	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,GAF_2,HAMP,HATPase_c,HisKA,Response_reg
TLS1_k127_7904174_1	195250.CM001776_gene935	9.43e-82	283.0	COG3437@1|root,COG3437@2|Bacteria,1G2ZH@1117|Cyanobacteria,1H05S@1129|Synechococcus	1117|Cyanobacteria	T	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
TLS1_k127_7904174_4	1299327.I546_1575	1.408e-09	69.0	2DMMA@1|root,32SDH@2|Bacteria,2IM8C@201174|Actinobacteria,23AE5@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
TLS1_k127_7904174_5	314285.KT71_04480	9.252e-06	51.0	COG2374@1|root,COG2374@2|Bacteria,1MX52@1224|Proteobacteria,1RMHH@1236|Gammaproteobacteria,1J6AJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	extracellular nuclease	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	DUF3616,Endonuclease_1,Exo_endo_phos,LTD
TLS1_k127_7908299_4	1210884.HG799462_gene8936	1.755e-23	104.0	COG2931@1|root,COG2931@2|Bacteria,2IZ0P@203682|Planctomycetes	203682|Planctomycetes	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
TLS1_k127_7908299_0	446470.Snas_1820	8.809e-217	687.0	COG2759@1|root,COG2759@2|Bacteria,2GT0X@201174|Actinobacteria	201174|Actinobacteria	H	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
TLS1_k127_7908299_3	477974.Daud_0103	8.411e-77	267.0	COG0190@1|root,COG0190@2|Bacteria,1TP1P@1239|Firmicutes,248DB@186801|Clostridia,2606K@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
TLS1_k127_7908299_5	1423775.BAMN01000005_gene1329	7.008e-22	109.0	COG3404@1|root,COG3404@2|Bacteria,1U463@1239|Firmicutes,4HKYN@91061|Bacilli,3FAIC@33958|Lactobacillaceae	91061|Bacilli	E	Formiminotransferase-cyclodeaminase	-	-	-	-	-	-	-	-	-	-	-	-	FTCD_C
TLS1_k127_7908299_2	1120973.AQXL01000119_gene533	1.039e-109	372.0	COG0389@1|root,COG0389@2|Bacteria,1TP42@1239|Firmicutes,4HADJ@91061|Bacilli,279NS@186823|Alicyclobacillaceae	91061|Bacilli	L	IMS family HHH motif	dinB	GO:0008150,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0050896	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
TLS1_k127_7908299_1	1122138.AQUZ01000019_gene8188	1.125e-206	656.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	sndH	-	-	-	-	-	-	-	-	-	-	-	GSDH
TLS1_k127_7938809_4	867845.KI911784_gene2126	5.882e-36	150.0	COG2258@1|root,COG2258@2|Bacteria,2G7HE@200795|Chloroflexi	200795|Chloroflexi	S	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
TLS1_k127_7938809_0	1120936.KB907221_gene2234	1.505e-234	745.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4EGC8@85012|Streptosporangiales	201174|Actinobacteria	I	Carboxyl transferase domain	accD1	-	6.4.1.4	ko:K01969	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
TLS1_k127_7938809_5	485918.Cpin_7088	1.07e-11	74.0	COG1510@1|root,COG1510@2|Bacteria,4NQPD@976|Bacteroidetes,1ISGU@117747|Sphingobacteriia	976|Bacteroidetes	K	Belongs to the GbsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5,MarR_2,TrmB
TLS1_k127_7938809_2	1128421.JAGA01000002_gene682	2.243e-136	443.0	COG0214@1|root,COG0214@2|Bacteria,2NNZ6@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
TLS1_k127_7938809_3	1121430.JMLG01000030_gene1610	7.209e-62	220.0	COG0311@1|root,COG0311@2|Bacteria,1V3I6@1239|Firmicutes,24HRT@186801|Clostridia,261H3@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	-	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
TLS1_k127_7938809_1	525904.Tter_0684	1.357e-142	481.0	COG3854@1|root,COG3854@2|Bacteria,2NQEN@2323|unclassified Bacteria	2|Bacteria	S	R3H domain	ycf45	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_30,R3H
TLS1_k127_8027309_8	886293.Sinac_6531	5.694e-10	61.0	2F5CV@1|root,33XYX@2|Bacteria,2J2Z4@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_8027309_6	316274.Haur_1012	3.007e-57	220.0	COG0454@1|root,COG1246@1|root,COG0456@2|Bacteria,COG1246@2|Bacteria,2G8UQ@200795|Chloroflexi	200795|Chloroflexi	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS1_k127_8027309_5	316274.Haur_1012	5.601e-60	220.0	COG0454@1|root,COG1246@1|root,COG0456@2|Bacteria,COG1246@2|Bacteria,2G8UQ@200795|Chloroflexi	200795|Chloroflexi	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS1_k127_8027309_1	118166.JH976537_gene1983	1.533e-95	336.0	COG1162@1|root,COG1162@2|Bacteria,1G18W@1117|Cyanobacteria,1H9XI@1150|Oscillatoriales	1117|Cyanobacteria	S	RsgA GTPase	-	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
TLS1_k127_8027309_3	1128421.JAGA01000003_gene3553	8.929e-86	292.0	COG0842@1|root,COG0842@2|Bacteria,2NQR6@2323|unclassified Bacteria	2|Bacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS1_k127_8027309_2	357808.RoseRS_2474	9.032e-87	299.0	COG1131@1|root,COG1131@2|Bacteria,2G5YX@200795|Chloroflexi,3762X@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS1_k127_8027309_7	404589.Anae109_2479	2.87e-40	157.0	COG0454@1|root,COG0456@2|Bacteria,1RD40@1224|Proteobacteria,43EF3@68525|delta/epsilon subdivisions,2X0ID@28221|Deltaproteobacteria,2Z1N2@29|Myxococcales	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS1_k127_8027309_4	1121946.AUAX01000002_gene36	4.173e-71	261.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4DF11@85008|Micromonosporales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS1_k127_8027309_0	525904.Tter_1872	1.271e-181	582.0	COG1239@1|root,COG1239@2|Bacteria,2NQQG@2323|unclassified Bacteria	2|Bacteria	H	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX	chlI	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	iNJ661.Rv0958	Mg_chelatase,Sigma54_activat
TLS1_k127_8027309_9	1382356.JQMP01000001_gene834	1.489e-09	63.0	COG4867@1|root,COG4867@2|Bacteria,2G8A6@200795|Chloroflexi,27XPF@189775|Thermomicrobia	189775|Thermomicrobia	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_8047356_3	1246995.AFR_26150	3.347e-62	224.0	COG3836@1|root,COG3836@2|Bacteria,2HGEA@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.2.20,4.1.2.52	ko:K01630,ko:K02510	ko00053,ko00350,ko01120,map00053,map00350,map01120	-	R01645,R01647,R02754,R03277	RC00307,RC00435,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
TLS1_k127_8047356_10	1122962.AULH01000008_gene2060	8.372e-07	56.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2U5A1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigW	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS1_k127_8047356_9	316274.Haur_0601	3.854e-13	78.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	M1-584	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS1_k127_8047356_4	1123389.ATXJ01000006_gene2212	6.186e-37	145.0	COG2402@1|root,COG2402@2|Bacteria,1WJXN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS1_k127_8047356_8	1330700.JQNC01000003_gene666	7.291e-17	82.0	2DSVR@1|root,33HKS@2|Bacteria,1WKIU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	Ribbon-helix-helix protein, copG family	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1,RHH_3,RHH_4
TLS1_k127_8047356_0	272134.KB731324_gene5904	9.737e-155	500.0	COG3508@1|root,COG3508@2|Bacteria,1G3C7@1117|Cyanobacteria,1HEU2@1150|Oscillatoriales	1117|Cyanobacteria	Q	homogentisate 1,2-dioxygenase	-	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
TLS1_k127_8047356_5	1380356.JNIK01000003_gene1231	1.504e-35	143.0	2BIEE@1|root,32T9G@2|Bacteria,2I86Y@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_8047356_2	1408254.T458_19215	4.246e-72	264.0	COG0179@1|root,COG0179@2|Bacteria,1UY98@1239|Firmicutes,4HC89@91061|Bacilli,26UR6@186822|Paenibacillaceae	91061|Bacilli	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	3.7.1.2	ko:K16171	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
TLS1_k127_8047356_1	1541065.JRFE01000014_gene1635	3.661e-113	395.0	COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,3VIJ3@52604|Pleurocapsales	1117|Cyanobacteria	T	COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,EAL,GGDEF,PAS,PAS_4
TLS1_k127_8047356_7	1379270.AUXF01000002_gene1849	2.437e-21	109.0	COG1595@1|root,COG1595@2|Bacteria,1ZT0A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS1_k127_903353_3	1297617.JPJD01000067_gene2201	7.85e-17	85.0	COG0050@1|root,COG0050@2|Bacteria,1TPKC@1239|Firmicutes,2485I@186801|Clostridia,267PG@186813|unclassified Clostridiales	186801|Clostridia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
TLS1_k127_903353_0	498761.HM1_1375	2.419e-319	1008.0	COG0480@1|root,COG0480@2|Bacteria,1TPF9@1239|Firmicutes,247VN@186801|Clostridia	186801|Clostridia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
TLS1_k127_903353_2	1382306.JNIM01000001_gene3553	2.19e-46	171.0	COG0049@1|root,COG0049@2|Bacteria,2G6GR@200795|Chloroflexi	200795|Chloroflexi	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
TLS1_k127_903353_1	485913.Krac_12533	2.735e-54	200.0	COG0048@1|root,COG0048@2|Bacteria,2G6EX@200795|Chloroflexi	200795|Chloroflexi	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
TLS1_k127_903353_4	298653.Franean1_6056	4.851e-05	50.0	COG0086@1|root,COG0086@2|Bacteria,2GKWF@201174|Actinobacteria,4ERS7@85013|Frankiales	201174|Actinobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
## 2575 queries scanned
## Total time (seconds): 320.9228777885437
## Rate: 8.02 q/s