## Thu Feb 19 18:18:45 2026
## emapper-2.1.13
## /data/anaconda3/envs/eggnog-mapper/bin/emapper.py -i /data/result/bins/wyx/bins/TLS1_bin.4.fa -m mmseqs --output TLS1_bin.4 --output_dir /data/result/bins/wyx/eggqs50+/TLS1_bin.4 --itype genome --cpu 8 --override
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
TLS1_k127_1059565_0	1459636.NTE_01785	2.154e-219	687.0	COG0498@1|root,arCOG01434@2157|Archaea,41S5N@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS1_k127_1059565_2	1459636.NTE_01973	8.67e-78	271.0	COG1575@1|root,arCOG00480@2157|Archaea,41S8H@651137|Thaumarchaeota	651137|Thaumarchaeota	H	UbiA prenyltransferase	-	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
TLS1_k127_1059565_3	1220534.B655_1964	1.513e-37	151.0	COG0340@1|root,arCOG01940@2157|Archaea,2XSZ5@28890|Euryarchaeota,23P57@183925|Methanobacteria	183925|Methanobacteria	H	Biotin lipoate A B protein ligase	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
TLS1_k127_1059565_1	1459636.NTE_01981	2.501e-87	304.0	COG2379@1|root,arCOG04170@2157|Archaea,41SJF@651137|Thaumarchaeota	651137|Thaumarchaeota	G	MOFRL family	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
TLS1_k127_1075606_5	1459636.NTE_01825	5.312e-32	127.0	COG1471@1|root,arCOG04093@2157|Archaea,41SIE@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the eukaryotic ribosomal protein eS4 family	rps4e	-	-	ko:K02987	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	RS4NT,Ribosomal_S4e,S4
TLS1_k127_1075606_6	1459636.NTE_01826	1.474e-28	119.0	COG0198@1|root,arCOG04094@2157|Archaea,41SSS@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Located at the polypeptide exit tunnel on the outside of the subunit	rpl24	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L26
TLS1_k127_1075606_1	1459636.NTE_01827	5.548e-75	253.0	COG0093@1|root,arCOG04095@2157|Archaea,41SHG@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rpl14	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
TLS1_k127_1075606_3	1459636.NTE_01828	1.347e-40	152.0	COG0186@1|root,arCOG04096@2157|Archaea,41SSH@651137|Thaumarchaeota	651137|Thaumarchaeota	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rps17	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
TLS1_k127_1075606_7	1459636.NTE_01829	3.598e-15	78.0	COG1588@1|root,arCOG00784@2157|Archaea,41TB4@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp1	-	3.1.26.5	ko:K03538	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	UPF0086
TLS1_k127_1075606_8	273057.SSO6397	2.831e-06	53.0	COG0255@1|root,arCOG00785@2157|Archaea	2157|Archaea	J	Belongs to the universal ribosomal protein uL29 family	rpl29	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
TLS1_k127_1075606_0	1459636.NTE_01831	8.417e-92	307.0	COG0092@1|root,arCOG04097@2157|Archaea,41SIM@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Binds the lower part of the 30S subunit head	rps3	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
TLS1_k127_1075606_2	1459636.NTE_01832	9.431e-75	253.0	COG0091@1|root,arCOG04098@2157|Archaea,41SJ4@651137|Thaumarchaeota	651137|Thaumarchaeota	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rpl22	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
TLS1_k127_1075606_4	1459636.NTE_01833	1.931e-34	132.0	COG0185@1|root,arCOG04099@2157|Archaea,41SMH@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rps19p	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
TLS1_k127_1099909_1	1459636.NTE_00772	1.995e-126	413.0	COG0601@1|root,arCOG00751@2157|Archaea,41S7B@651137|Thaumarchaeota	651137|Thaumarchaeota	P	inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS1_k127_1099909_0	1459636.NTE_00771	6.673e-160	516.0	COG1173@1|root,arCOG00749@2157|Archaea,41SFE@651137|Thaumarchaeota	651137|Thaumarchaeota	P	inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS1_k127_1101301_3	1121335.Clst_0988	6.245e-06	49.0	COG1082@1|root,COG1082@2|Bacteria,1TRXP@1239|Firmicutes,24EWV@186801|Clostridia,3WKWE@541000|Ruminococcaceae	186801|Clostridia	G	Sugar phosphate isomerases epimerases	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS1_k127_1101301_1	319003.Bra1253DRAFT_07505	8.05e-67	240.0	COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,2TRMH@28211|Alphaproteobacteria,3JRIF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Histidine-specific methyltransferase, SAM-dependent	MA20_09135	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_33
TLS1_k127_1101301_0	1131266.ARWQ01000011_gene107	6.885e-140	457.0	COG1262@1|root,arCOG03517@2157|Archaea,41T1B@651137|Thaumarchaeota	651137|Thaumarchaeota	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase
TLS1_k127_1110085_0	1459636.NTE_01754	3.909e-90	314.0	COG0608@1|root,arCOG00427@2157|Archaea,41SZF@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DHHA1 domain	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHHA1
TLS1_k127_1110085_1	1459636.NTE_01753	5.117e-53	192.0	COG0184@1|root,arCOG04185@2157|Archaea,41SKP@651137|Thaumarchaeota	651137|Thaumarchaeota	J	ribosomal protein	rps15	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13_N,Ribosomal_S15
TLS1_k127_1110085_4	1459636.NTE_01752	0.0005026	49.0	arCOG10587@1|root,arCOG10587@2157|Archaea,41SVM@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_1110085_2	1459636.NTE_01751	4.098e-39	147.0	arCOG08672@1|root,arCOG08672@2157|Archaea,41SU2@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_1110085_3	1459636.NTE_01761	8.706e-27	110.0	COG1032@1|root,arCOG01363@2157|Archaea,41S6P@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS1_k127_1112973_0	234267.Acid_0846	1.295e-109	361.0	COG0656@1|root,COG0656@2|Bacteria	2|Bacteria	S	aldo-keto reductase (NADP) activity	MA20_17035	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS1_k127_1115194_2	69014.TK0105	1.164e-06	51.0	arCOG07843@1|root,arCOG07843@2157|Archaea,2Y54E@28890|Euryarchaeota,2458B@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_1115194_1	1459636.NTE_00833	5.753e-101	334.0	COG0778@1|root,arCOG00288@2157|Archaea,41S7D@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Cob(II)yrinic acid a,c-diamide reductase	-	-	1.13.11.79	ko:K04719	ko00740,ko01100,map00740,map01100	-	R09083	RC00435,RC02413	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
TLS1_k127_1115194_0	1459636.NTE_00832	4.659e-264	835.0	arCOG08801@1|root,arCOG08801@2157|Archaea	2157|Archaea	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_1148641_1	1170562.Cal6303_3700	2.317e-06	55.0	COG0515@1|root,COG0515@2|Bacteria,1GHWT@1117|Cyanobacteria,1HR2V@1161|Nostocales	1117|Cyanobacteria	KLT	PFAM Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,PsbP
TLS1_k127_1148641_0	1459636.NTE_02468	8.558e-150	488.0	COG0621@1|root,arCOG01358@2157|Archaea,41SB9@651137|Thaumarchaeota	651137|Thaumarchaeota	J	MiaB-like tRNA modifying enzyme	-	-	2.8.4.5	ko:K15865	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
TLS1_k127_1153094_0	1459636.NTE_03297	1.919e-164	528.0	COG0513@1|root,arCOG00558@2157|Archaea,41SM1@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DEAD DEAH box helicase	-	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,Helicase_C
TLS1_k127_1153094_1	1459636.NTE_01054	1.905e-43	162.0	arCOG08023@1|root,arCOG08023@2157|Archaea,41SKK@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Zinc finger domain	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
TLS1_k127_118995_0	1131266.ARWQ01000028_gene1022	7.834e-170	541.0	COG1866@1|root,arCOG06073@2157|Archaea,41SE5@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
TLS1_k127_118995_1	1459636.NTE_01942	4.255e-42	158.0	COG0484@1|root,arCOG02846@2157|Archaea,41T68@651137|Thaumarchaeota	651137|Thaumarchaeota	O	DnaJ molecular chaperone homology domain	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ
TLS1_k127_1280417_0	350688.Clos_0533	4.001e-154	500.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1TNZ1@1239|Firmicutes,247PS@186801|Clostridia,36DCY@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH,NMO
TLS1_k127_1300934_3	1459636.NTE_02238	3.396e-18	85.0	COG0031@1|root,arCOG01430@2157|Archaea,41SYM@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Cysteine synthase	-	-	2.5.1.47	ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS1_k127_1300934_2	1459636.NTE_02237	7.597e-34	131.0	COG0425@1|root,arCOG02062@2157|Archaea,41SU5@651137|Thaumarchaeota	651137|Thaumarchaeota	O	redox protein, regulator of disulfide bond formation	-	-	-	-	-	-	-	-	-	-	-	-	TusA
TLS1_k127_1300934_0	1459636.NTE_02235	6.634e-80	274.0	COG1478@1|root,arCOG02714@2157|Archaea,41T27@651137|Thaumarchaeota	651137|Thaumarchaeota	H	F420-0:Gamma-glutamyl ligase	-	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
TLS1_k127_1300934_1	1459636.NTE_02233	6.207e-53	188.0	COG0560@1|root,arCOG01158@2157|Archaea,41SHX@651137|Thaumarchaeota	651137|Thaumarchaeota	E	phosphoserine phosphatase	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD
TLS1_k127_1312978_1	1459636.NTE_01058	3.21e-49	177.0	arCOG04732@1|root,arCOG04732@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_1312978_0	1459636.NTE_01059	9.1e-195	612.0	COG1201@1|root,arCOG00557@2157|Archaea,41S8P@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DEAD/H associated	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
TLS1_k127_1328187_1	556261.HMPREF0240_02111	2.047e-56	209.0	COG1402@1|root,COG1402@2|Bacteria,1V0N8@1239|Firmicutes,24B66@186801|Clostridia,36W4B@31979|Clostridiaceae	186801|Clostridia	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
TLS1_k127_1328187_0	1459636.NTE_02629	3.705e-191	611.0	COG0174@1|root,arCOG01909@2157|Archaea,41SD6@651137|Thaumarchaeota	2157|Archaea	E	TIGRFAM glutamine synthetase, type I	glnA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
TLS1_k127_1337696_0	1459636.NTE_00981	4.324e-227	711.0	COG0423@1|root,arCOG00405@2157|Archaea,41S8S@651137|Thaumarchaeota	651137|Thaumarchaeota	J	synthetase (class II)	-	-	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
TLS1_k127_1337696_1	1459636.NTE_02274	1.658e-42	158.0	COG1018@1|root,arCOG02200@2157|Archaea,41S72@651137|Thaumarchaeota	651137|Thaumarchaeota	C	oxidoreductase FAD NAD(P)-binding	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	FAD_binding_6,NAD_binding_1
TLS1_k127_1347029_6	1459636.NTE_00604	2.026e-14	78.0	COG0260@1|root,arCOG04322@2157|Archaea,41SYD@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
TLS1_k127_1347029_0	1459636.NTE_00602	5.81e-269	837.0	COG0036@1|root,COG3959@1|root,arCOG01053@2157|Archaea,arCOG05046@2157|Archaea,41SBE@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim,Transketolase_N
TLS1_k127_1347029_5	1121430.JMLG01000004_gene964	4.006e-95	321.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,26093@186807|Peptococcaceae	186801|Clostridia	G	PFAM Transketolase, C-terminal domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
TLS1_k127_1347029_4	1459636.NTE_00600	9.831e-100	329.0	COG0176@1|root,arCOG05061@2157|Archaea,41S99@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
TLS1_k127_1347029_1	1459636.NTE_00599	1.519e-210	668.0	COG2304@1|root,arCOG02900@2157|Archaea,41SDY@651137|Thaumarchaeota	651137|Thaumarchaeota	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_1347029_3	1459636.NTE_00598	2.466e-114	374.0	COG0714@1|root,arCOG00441@2157|Archaea,41SDZ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA_5
TLS1_k127_1347029_2	1459636.NTE_02230	2.485e-121	394.0	COG2304@1|root,arCOG02900@2157|Archaea	2157|Archaea	O	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
TLS1_k127_1366799_0	1459636.NTE_02211	8.7e-137	439.0	COG1250@1|root,arCOG00249@2157|Archaea	2157|Archaea	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.116,4.2.1.17	ko:K01715,ko:K15019	ko00650,ko00720,ko01120,ko01200,map00650,map00720,map01120,map01200	M00375	R03026,R03045	RC00831,RC00834	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS1_k127_1366799_1	1459636.NTE_02212	3.47e-94	320.0	COG0083@1|root,arCOG01027@2157|Archaea,41S89@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	-	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
TLS1_k127_1366799_2	1459636.NTE_02213	3.554e-38	146.0	COG1100@1|root,arCOG01225@2157|Archaea,41T0A@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Conserved hypothetical ATP binding protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	ATP_bind_1
TLS1_k127_137867_1	998674.ATTE01000001_gene150	2.242e-07	58.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,45ZQ4@72273|Thiotrichales	72273|Thiotrichales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
TLS1_k127_1389668_1	1229909.NSED_06125	2.354e-08	62.0	arCOG08727@1|root,arCOG08727@2157|Archaea,41T57@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_1389668_0	1459636.NTE_03299	4.239e-36	140.0	arCOG08025@1|root,arCOG08025@2157|Archaea,41STV@651137|Thaumarchaeota	651137|Thaumarchaeota	S	zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
TLS1_k127_1449311_0	1459636.NTE_02410	2.328e-81	276.0	COG3467@1|root,arCOG00520@2157|Archaea,41SJ5@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Pyridoxamine 5'-phosphate	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
TLS1_k127_1449311_2	1459636.NTE_02959	5.89e-50	187.0	COG2095@1|root,arCOG01997@2157|Archaea	2157|Archaea	U	UPF0056 membrane protein	snatA	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
TLS1_k127_1449311_1	1459636.NTE_01294	5.41e-61	219.0	COG0586@1|root,arCOG03117@2157|Archaea,41SQ5@651137|Thaumarchaeota	651137|Thaumarchaeota	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TLS1_k127_1451629_2	1459636.NTE_01636	3.613e-33	129.0	COG0615@1|root,arCOG03924@1|root,arCOG01222@2157|Archaea,arCOG03924@2157|Archaea,41SPR@651137|Thaumarchaeota	651137|Thaumarchaeota	M	Cytidylyltransferase-like	-	-	2.7.7.2,2.7.7.39	ko:K00980,ko:K14656	ko00564,ko00740,ko01100,ko01110,map00564,map00740,map01100,map01110	-	R00161,R00856	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
TLS1_k127_1451629_1	1459636.NTE_01635	9.815e-69	240.0	COG1339@1|root,arCOG01904@2157|Archaea,41SG9@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Domain of unknown function DUF120	-	-	2.7.1.161	ko:K07732	ko00740,ko01100,map00740,map01100	-	R08574	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CTP-dep_RFKase
TLS1_k127_1451629_0	1459636.NTE_01634	1.85e-175	558.0	COG0358@1|root,arCOG04281@2157|Archaea,41S75@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA primase	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
TLS1_k127_1467626_3	1459636.NTE_00038	3.812e-22	96.0	COG0346@1|root,arCOG02708@2157|Archaea	2157|Archaea	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	-	ko:K07032	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS1_k127_1467626_1	1459636.NTE_02379	4.227e-44	168.0	COG0009@1|root,arCOG01952@2157|Archaea,41SPF@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Sua5 YciO YrdC YwlC family	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
TLS1_k127_1467626_4	1459636.NTE_02174	4.77e-07	56.0	COG1715@1|root,arCOG02777@2157|Archaea	2157|Archaea	V	restriction endonuclease	-	-	-	ko:K07448	-	-	-	-	ko00000,ko02048	-	-	-	Mrr_cat
TLS1_k127_1467626_2	547144.HydHO_1068	1.279e-22	106.0	COG0509@1|root,COG0509@2|Bacteria	2|Bacteria	E	glycine decarboxylation via glycine cleavage system	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
TLS1_k127_1467626_0	1459636.NTE_01352	1.859e-124	404.0	COG2897@1|root,arCOG02019@2157|Archaea,41SZQ@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
TLS1_k127_1468931_1	1459636.NTE_02506	2.723e-91	314.0	arCOG01390@1|root,arCOG01390@2157|Archaea,41S7Q@651137|Thaumarchaeota	651137|Thaumarchaeota	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS1_k127_1468931_0	1459636.NTE_02503	3.362e-144	469.0	COG1060@1|root,arCOG00657@2157|Archaea,41S95@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Radical SAM	-	-	2.5.1.77	ko:K11780	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
TLS1_k127_1470738_1	1459636.NTE_01112	1.035e-77	261.0	COG0059@1|root,arCOG04465@2157|Archaea,41S65@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
TLS1_k127_1470738_2	1459636.NTE_01111	1.533e-60	212.0	COG2185@1|root,arCOG01710@2157|Archaea,41SJN@651137|Thaumarchaeota	651137|Thaumarchaeota	I	B12 binding domain	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
TLS1_k127_1470738_0	1459636.NTE_01109	2.864e-110	365.0	COG1703@1|root,arCOG01226@2157|Archaea,41SFN@651137|Thaumarchaeota	651137|Thaumarchaeota	E	LAO AO transport system ATPase	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
TLS1_k127_1470738_3	1459636.NTE_01108	5.097e-38	146.0	COG1884@1|root,arCOG04232@2157|Archaea,41SBW@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
TLS1_k127_1483232_1	1459636.NTE_02891	3.666e-51	183.0	COG0832@1|root,arCOG04527@2157|Archaea	2157|Archaea	E	Belongs to the urease beta subunit family	ureB	-	3.5.1.5	ko:K01429,ko:K14048	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Urease_beta,Urease_gamma
TLS1_k127_1483232_2	1459636.NTE_02892	7.496e-50	179.0	COG0831@1|root,arCOG04528@2157|Archaea,41SPI@651137|Thaumarchaeota	2157|Archaea	E	(urease) gamma subunit	ureA	-	3.5.1.5	ko:K01430,ko:K14048	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Urease_beta,Urease_gamma
TLS1_k127_1531977_3	1459636.NTE_01333	7.335e-20	93.0	arCOG08708@1|root,arCOG08708@2157|Archaea,41SPK@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_1531977_2	1459636.NTE_01334	3.896e-24	104.0	arCOG07810@1|root,arCOG07810@2157|Archaea,41T26@651137|Thaumarchaeota	651137|Thaumarchaeota	T	PFAM Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
TLS1_k127_1531977_1	1459636.NTE_00799	1.468e-95	320.0	COG2107@1|root,arCOG00654@2157|Archaea,41SB8@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnD	-	-	ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
TLS1_k127_1531977_0	1459636.NTE_00789	6.101e-185	584.0	COG1060@1|root,arCOG00656@2157|Archaea,41SEG@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Radical SAM	-	-	2.5.1.120	ko:K18285	ko00130,ko01110,map00130,map01110	-	R10667	RC00021,RC03234	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
TLS1_k127_1543788_1	1459636.NTE_01128	2.057e-15	81.0	arCOG00516@1|root,arCOG00516@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS1_k127_1543788_0	1268072.PSAB_04425	3.193e-121	402.0	COG1073@1|root,COG1073@2|Bacteria,1TRSD@1239|Firmicutes,4HENH@91061|Bacilli,275PK@186822|Paenibacillaceae	91061|Bacilli	S	Belongs to the UPF0255 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1100
TLS1_k127_1543788_2	1459636.NTE_02677	1.328e-06	51.0	arCOG08764@1|root,arCOG08764@2157|Archaea,41TBI@651137|Thaumarchaeota	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_1545327_2	679926.Mpet_0745	1.412e-12	74.0	COG0517@1|root,arCOG00606@2157|Archaea,2XX11@28890|Euryarchaeota,2N9VZ@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS1_k127_1545327_1	1459636.NTE_01733	2.458e-69	242.0	COG2082@1|root,COG2138@1|root,arCOG02246@2157|Archaea,arCOG02247@2157|Archaea,41SH6@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Cobalt chelatase (CbiK)	-	-	5.4.99.60,5.4.99.61	ko:K06042	ko00860,ko01100,map00860,map01100	-	R05177,R05814	RC01292,RC01980	ko00000,ko00001,ko01000	-	-	-	CbiX
TLS1_k127_1545327_0	1459636.NTE_01733	3.628e-70	244.0	COG2082@1|root,COG2138@1|root,arCOG02246@2157|Archaea,arCOG02247@2157|Archaea,41SH6@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Cobalt chelatase (CbiK)	-	-	5.4.99.60,5.4.99.61	ko:K06042	ko00860,ko01100,map00860,map01100	-	R05177,R05814	RC01292,RC01980	ko00000,ko00001,ko01000	-	-	-	CbiX
TLS1_k127_154768_0	530564.Psta_1631	2.809e-89	307.0	COG1090@1|root,COG4276@1|root,COG1090@2|Bacteria,COG4276@2|Bacteria,2IXEW@203682|Planctomycetes	203682|Planctomycetes	S	epimerase	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase,Polyketide_cyc
TLS1_k127_1558875_2	693661.Arcve_0993	1.47e-96	325.0	COG0383@1|root,arCOG03661@2157|Archaea,2XVNX@28890|Euryarchaeota	28890|Euryarchaeota	G	Alpha mannosidase, middle domain	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
TLS1_k127_1558875_1	123214.PERMA_0470	2.033e-130	424.0	COG0057@1|root,COG0057@2|Bacteria,2G3TK@200783|Aquificae	200783|Aquificae	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
TLS1_k127_1558875_0	1313301.AUGC01000001_gene1411	1.484e-196	624.0	COG4799@1|root,COG4799@2|Bacteria,4NEMJ@976|Bacteroidetes	976|Bacteroidetes	I	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	pccB	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
TLS1_k127_1678781_0	1459636.NTE_01021	1.152e-86	300.0	COG0265@1|root,arCOG02833@2157|Archaea,41S9W@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Trypsin-like serine protease with C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
TLS1_k127_1678781_1	1459636.NTE_00315	1.592e-19	94.0	COG2132@1|root,COG3794@1|root,arCOG02926@2157|Archaea,arCOG03914@2157|Archaea,41SWV@651137|Thaumarchaeota	2157|Archaea	CQ	multicopper	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1
TLS1_k127_1710266_2	99598.Cal7507_1418	9.127e-09	66.0	COG1215@1|root,COG1215@2|Bacteria,1FZYV@1117|Cyanobacteria,1HIVJ@1161|Nostocales	1117|Cyanobacteria	M	PFAM Glycosyl transferase family 2	-	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006629,GO:0006643,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046872,GO:0071704,GO:1901576	2.4.1.336	ko:K19003	ko00561,ko01100,map00561,map01100	-	R02689	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glyco_tranf_2_3
TLS1_k127_1710266_1	1459636.NTE_00767	3.347e-51	188.0	arCOG08739@1|root,arCOG08739@2157|Archaea,41SN6@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_1710266_0	1459636.NTE_00770	2.911e-57	201.0	COG0231@1|root,arCOG04277@2157|Archaea,41SNP@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Functions by promoting the formation of the first peptide bond	eif5a	-	-	ko:K03263	-	-	-	-	ko00000,ko03012	-	-	-	eIF-5a
TLS1_k127_1733869_0	1459636.NTE_00264	6.951e-76	257.0	arCOG01792@1|root,arCOG01792@2157|Archaea	2157|Archaea	K	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS1_k127_1733869_1	1459636.NTE_00264	3.453e-42	155.0	arCOG01792@1|root,arCOG01792@2157|Archaea	2157|Archaea	K	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS1_k127_1737144_0	1459636.NTE_01097	1.637e-131	423.0	COG0473@1|root,arCOG01163@2157|Archaea,41S5U@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Isocitrate isopropylmalate dehydrogenase	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TLS1_k127_1737144_2	224719.Abm4_1662	6.217e-16	85.0	COG2890@1|root,arCOG00109@2157|Archaea,2XWJZ@28890|Euryarchaeota,23P23@183925|Methanobacteria	183925|Methanobacteria	Q	Lysine methyltransferase	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
TLS1_k127_1737144_1	1459636.NTE_01095	1.013e-47	180.0	COG0030@1|root,arCOG04131@2157|Archaea,41SN0@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family	-	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
TLS1_k127_1737144_3	1459636.NTE_01094	3.433e-13	69.0	COG1491@1|root,arCOG04130@2157|Archaea,41SGD@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Protein of unknown function (DUF655)	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
TLS1_k127_1753123_0	1459636.NTE_01529	1.253e-52	200.0	COG0382@1|root,arCOG00476@2157|Archaea	2157|Archaea	I	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids	-	-	2.5.1.42,2.5.1.74	ko:K02548,ko:K17105,ko:K20616	ko00130,ko00564,ko01100,ko01110,map00130,map00564,map01100,map01110	M00116	R04520,R05617,R06858,R10757	RC01171,RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
TLS1_k127_1753123_1	1459636.NTE_00861	2.556e-50	184.0	COG4742@1|root,arCOG04362@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS1_k127_1777716_1	1459636.NTE_01914	6.177e-67	237.0	COG0134@1|root,arCOG01088@2157|Archaea,41SN7@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Indole-3-glycerol phosphate synthase	-	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
TLS1_k127_1777716_2	1459636.NTE_01667	3.88e-31	125.0	arCOG08684@1|root,arCOG08684@2157|Archaea,41T64@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_1777716_0	1459636.NTE_00160	3.756e-110	379.0	COG0642@1|root,arCOG03644@1|root,arCOG02358@2157|Archaea,arCOG03644@2157|Archaea	2157|Archaea	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07709	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	CHASE4,HAMP,HATPase_c,HisKA,PAS_4,PAS_9,Response_reg,dCache_1,sCache_3_3
TLS1_k127_1777716_4	1459636.NTE_02770	0.0002964	44.0	arCOG11305@1|root,arCOG11305@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_1860659_1	1278073.MYSTI_01667	1.292e-45	173.0	COG1090@1|root,COG4276@1|root,COG1090@2|Bacteria,COG4276@2|Bacteria,1MUB4@1224|Proteobacteria,42PQ2@68525|delta/epsilon subdivisions,2WK6V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1731)	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase,Polyketide_cyc
TLS1_k127_1860659_2	1459636.NTE_02704	1.135e-32	128.0	arCOG08662@1|root,arCOG08662@2157|Archaea,41SQG@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_1860659_3	1459636.NTE_02651	2.579e-29	120.0	COG2146@1|root,arCOG02852@2157|Archaea,41T71@651137|Thaumarchaeota	651137|Thaumarchaeota	P	of nitrite reductase and ring-hydroxylating	-	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
TLS1_k127_1860659_0	1459636.NTE_03057	2.792e-62	220.0	COG0237@1|root,arCOG01045@2157|Archaea,41SI8@651137|Thaumarchaeota	651137|Thaumarchaeota	H	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_17
TLS1_k127_1860659_4	1459636.NTE_02683	2.228e-13	70.0	COG0177@1|root,arCOG00459@2157|Archaea,41SFM@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
TLS1_k127_1865055_0	1459636.NTE_01638	3.311e-165	527.0	COG1602@1|root,arCOG04269@2157|Archaea,41S7H@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Archaeal Nre, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
TLS1_k127_1868811_0	1459636.NTE_02840	5.976e-143	460.0	COG1759@1|root,arCOG04346@2157|Archaea,41SBR@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates	purP	-	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
TLS1_k127_1868811_1	1459636.NTE_00828	8.557e-51	184.0	arCOG04006@1|root,arCOG04006@2157|Archaea,41SKF@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PBS lyase HEAT-like repeat	-	-	1.14.99.29	ko:K06072	-	-	-	-	ko00000,ko01000	-	-	-	HEAT_2
TLS1_k127_189060_1	1459636.NTE_00987	4.521e-84	283.0	COG0406@1|root,arCOG01991@2157|Archaea,41SJM@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Phosphoglycerate mutase family	-	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
TLS1_k127_189060_0	1459636.NTE_00986	5.17e-86	290.0	COG2085@1|root,arCOG00457@2157|Archaea,41SH2@651137|Thaumarchaeota	651137|Thaumarchaeota	S	PFAM NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
TLS1_k127_189060_2	1459636.NTE_00985	8.842e-24	104.0	arCOG08823@1|root,arCOG08823@2157|Archaea,41SW2@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_1924992_0	1459636.NTE_02001	1.068e-129	420.0	COG1131@1|root,arCOG00194@2157|Archaea	2157|Archaea	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS1_k127_1924992_1	1459636.NTE_02317	1.615e-74	252.0	COG1321@1|root,arCOG02099@2157|Archaea,41TBG@651137|Thaumarchaeota	2157|Archaea	K	PFAM Iron dependent repressor, metal binding and dimerisation domain	sirR	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
TLS1_k127_1924992_2	1459636.NTE_03123	9.514e-57	199.0	COG0459@1|root,arCOG01257@2157|Archaea,41SDG@651137|Thaumarchaeota	651137|Thaumarchaeota	O	PFAM TCP-1 cpn60 chaperonin family	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
TLS1_k127_193438_0	1459636.NTE_01902	7.075e-193	609.0	COG1503@1|root,arCOG01742@2157|Archaea,41SEK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
TLS1_k127_1941007_2	1459636.NTE_03329	6.379e-24	103.0	COG0431@1|root,arCOG04624@2157|Archaea	2157|Archaea	S	NAD(P)H-dependent FMN reductase	ssuE1	-	1.5.1.38	ko:K00299	ko00740,ko00920,ko01100,map00740,map00920,map01100	-	R05706,R07210,R10206	RC00126,RC01779,RC02556	ko00000,ko00001,ko01000	-	-	-	FMN_red
TLS1_k127_1941007_1	1229909.NSED_02445	5.112e-48	177.0	COG0580@1|root,arCOG04431@2157|Archaea,41SJI@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Major Intrinsic Protein	-	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
TLS1_k127_1941007_0	1459636.NTE_00057	2.026e-49	180.0	COG0394@1|root,arCOG04425@2157|Archaea,41T49@651137|Thaumarchaeota	651137|Thaumarchaeota	T	PFAM low molecular weight phosphotyrosine protein phosphatase	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
TLS1_k127_1951917_1	1459636.NTE_01967	6.208e-45	170.0	COG0518@1|root,arCOG00087@2157|Archaea,41SQR@651137|Thaumarchaeota	651137|Thaumarchaeota	F	glutamine amidotransferase	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
TLS1_k127_1951917_0	1459636.NTE_02267	1.441e-143	459.0	COG0179@1|root,arCOG00235@2157|Archaea,41S5K@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
TLS1_k127_1951917_2	1459636.NTE_02266	8.442e-22	98.0	COG0008@1|root,arCOG04302@2157|Archaea,41S5V@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
TLS1_k127_1955651_0	1459636.NTE_03196	1.91e-145	472.0	COG0141@1|root,arCOG04352@2157|Archaea,41S6J@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
TLS1_k127_1955651_1	1459636.NTE_03197	2.052e-96	327.0	COG0079@1|root,arCOG04273@2157|Archaea,41SGB@651137|Thaumarchaeota	651137|Thaumarchaeota	E	PFAM Aminotransferase class I and II	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS1_k127_1955651_2	1459636.NTE_03198	3.572e-20	96.0	COG0546@1|root,arCOG04692@2157|Archaea,41SJ6@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2,Hydrolase
TLS1_k127_1970079_1	1459636.NTE_01993	5.48e-178	563.0	COG0034@1|root,arCOG00093@2157|Archaea,41S7N@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,Pribosyltran
TLS1_k127_1970079_0	1459636.NTE_01994	4.634e-249	788.0	COG0046@1|root,arCOG00641@2157|Archaea,41S6S@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
TLS1_k127_1970079_2	1459636.NTE_01995	6.158e-91	304.0	COG0047@1|root,arCOG00102@2157|Archaea,41SG3@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
TLS1_k127_1970079_4	1459636.NTE_01997	3.794e-20	93.0	COG1828@1|root,arCOG04462@2157|Archaea,41STY@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
TLS1_k127_1970079_3	1459636.NTE_01843	2.696e-32	128.0	COG0152@1|root,arCOG04421@2157|Archaea,41SAR@651137|Thaumarchaeota	651137|Thaumarchaeota	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
TLS1_k127_1972381_0	1459636.NTE_01522	1.379e-176	563.0	COG1960@1|root,arCOG01707@2157|Archaea	2157|Archaea	I	COG1960 Acyl-CoA dehydrogenases	gcdH	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS1_k127_1972381_1	1459636.NTE_01288	4.358e-162	516.0	COG0644@1|root,arCOG00570@2157|Archaea,41SCG@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	-	-	-	-	-	-	-	-	-	-	Trp_halogenase
TLS1_k127_2028680_2	1459636.NTE_01195	5.174e-35	134.0	COG1522@1|root,arCOG01117@2157|Archaea	1459636.NTE_01195|-	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_2028680_3	1459636.NTE_01194	7.668e-09	58.0	arCOG08679@1|root,arCOG08679@2157|Archaea	2157|Archaea	S	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_2028680_1	1459636.NTE_01193	1.726e-94	319.0	COG0071@1|root,COG0705@1|root,arCOG01768@2157|Archaea,arCOG01833@2157|Archaea,41SKD@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
TLS1_k127_2028680_4	1056495.Calag_1351	4.323e-08	62.0	COG0723@1|root,arCOG01720@2157|Archaea,2XQYD@28889|Crenarchaeota	28889|Crenarchaeota	P	PFAM Rieske 2Fe-2S domain	soxF	-	-	-	-	-	-	-	-	-	-	-	Rieske
TLS1_k127_2028680_0	1459636.NTE_01577	1.756e-253	792.0	COG1290@1|root,arCOG01721@2157|Archaea,41SDA@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Cytochrome b subunit of the bc complex	-	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
TLS1_k127_205064_1	1459636.NTE_03061	3.452e-100	335.0	COG0842@1|root,arCOG01467@2157|Archaea,41SQQ@651137|Thaumarchaeota	651137|Thaumarchaeota	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS1_k127_205064_0	1459636.NTE_03060	1.234e-120	395.0	COG1131@1|root,arCOG00196@2157|Archaea,41S73@651137|Thaumarchaeota	651137|Thaumarchaeota	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS1_k127_208659_1	1459636.NTE_00681	4.728e-111	367.0	COG0010@1|root,arCOG01700@2157|Archaea,41T03@651137|Thaumarchaeota	2157|Archaea	E	Belongs to the arginase family	speB	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
TLS1_k127_208659_0	1459636.NTE_00680	8.106e-247	778.0	COG0441@1|root,arCOG00401@2157|Archaea,41S9K@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-II aminoacyl-tRNA synthetase family	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-Thr_ED,tRNA-synt_2b
TLS1_k127_208659_3	1459636.NTE_00679	7.656e-22	96.0	arCOG05330@1|root,arCOG05330@2157|Archaea,41SUC@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_208659_2	246197.MXAN_4914	1.158e-44	177.0	COG3291@1|root,COG3291@2|Bacteria,1QXUX@1224|Proteobacteria	1224|Proteobacteria	Q	F5/8 type C domain	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_lyase2,F5_F8_type_C
TLS1_k127_2088910_1	1459636.NTE_02485	7.171e-66	233.0	COG0322@1|root,arCOG04753@2157|Archaea,41SX9@651137|Thaumarchaeota	651137|Thaumarchaeota	L	TIGRFAM excinuclease ABC, C subunit	-	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,UVR,UvrC_HhH_N
TLS1_k127_2088910_0	1459636.NTE_01734	4.317e-146	476.0	COG1797@1|root,arCOG00106@2157|Archaea,41SBP@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source	cbiA	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	-	CbiA,GATase_3
TLS1_k127_2097962_2	1229909.NSED_07420	1.162e-62	222.0	COG0456@1|root,arCOG00833@2157|Archaea	2157|Archaea	C	PFAM GCN5-related N-acetyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
TLS1_k127_2097962_0	1229909.NSED_07415	3.658e-103	342.0	COG2159@1|root,arCOG01931@2157|Archaea	2157|Archaea	S	metal-dependent hydrolase of the TIM-barrel fold	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
TLS1_k127_2097962_3	1459636.NTE_01713	2.549e-28	119.0	COG0346@1|root,arCOG02708@2157|Archaea,41SU3@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Glyoxalase-like domain	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase,Glyoxalase_2
TLS1_k127_2097962_1	1459636.NTE_01099	1.346e-102	340.0	COG1409@1|root,arCOG01153@2157|Archaea,41SF2@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
TLS1_k127_2097962_4	1459636.NTE_00539	8.605e-16	83.0	arCOG08684@1|root,arCOG08684@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_2191120_0	1042163.BRLA_c023140	1.396e-53	195.0	COG1099@1|root,COG1099@2|Bacteria,1UZM4@1239|Firmicutes,4HEKY@91061|Bacilli	91061|Bacilli	S	TatD related DNase	-	-	-	ko:K07051	-	-	-	-	ko00000	-	-	-	TatD_DNase
TLS1_k127_2193793_1	1459636.NTE_00612	1.06e-79	268.0	COG0456@1|root,arCOG00833@2157|Archaea,41SIY@651137|Thaumarchaeota	651137|Thaumarchaeota	K	FR47-like protein	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
TLS1_k127_2193793_2	1229909.NSED_01415	7.018e-06	51.0	COG5625@1|root,arCOG04189@2157|Archaea,41T7F@651137|Thaumarchaeota	651137|Thaumarchaeota	K	HTH DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_2193793_0	1459636.NTE_00608	6.206e-80	273.0	COG2520@1|root,arCOG00033@2157|Archaea,41S7P@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Met-10+ like-protein	-	-	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
TLS1_k127_2232984_4	1459636.NTE_01833	5.364e-63	218.0	COG0185@1|root,arCOG04099@2157|Archaea,41SMH@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rps19p	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
TLS1_k127_2232984_7	1459636.NTE_01834	9.522e-28	114.0	COG0089@1|root,arCOG04072@2157|Archaea,41SS4@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome	rpl23	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
TLS1_k127_2232984_2	1459636.NTE_01835	6.941e-86	291.0	COG0469@1|root,arCOG04071@2157|Archaea,41SHB@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Ribosomal protein L4	-	-	-	ko:K02930	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
TLS1_k127_2232984_0	1459636.NTE_01836	1.567e-130	424.0	COG0087@1|root,arCOG04070@2157|Archaea,41SDN@651137|Thaumarchaeota	651137|Thaumarchaeota	J	ribosomal protein L3	-	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
TLS1_k127_2232984_5	1459636.NTE_01837	1.209e-54	202.0	COG2106@1|root,arCOG04069@2157|Archaea,41SI7@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Putative RNA methyltransferase	-	-	-	ko:K09142	-	-	-	-	ko00000	-	-	-	Methyltrn_RNA_3
TLS1_k127_2232984_3	1459636.NTE_01838	6.863e-75	257.0	arCOG08717@1|root,arCOG08717@2157|Archaea,41SFQ@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS1_k127_2232984_1	1459636.NTE_01839	7.947e-128	411.0	COG0638@1|root,arCOG00971@2157|Archaea,41SYA@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Proteasome endopeptidase complex	-	-	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
TLS1_k127_2232984_6	1459636.NTE_01841	3.505e-31	126.0	COG2090@1|root,arCOG04171@2157|Archaea,41SNF@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Domain of unknown function (DUF371)	-	-	-	ko:K09738	-	-	-	-	ko00000	-	-	-	DUF371
TLS1_k127_2265174_1	456442.Mboo_0940	1.709e-20	104.0	COG0420@1|root,arCOG00397@2157|Archaea,2XT7A@28890|Euryarchaeota,2NA2J@224756|Methanomicrobia	224756|Methanomicrobia	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity	mre11	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
TLS1_k127_2265174_0	1459636.NTE_03243	2.033e-25	114.0	2C5D3@1|root,2N5BY@2157|Archaea,41TAU@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_233413_2	1459636.NTE_02237	8.108e-11	62.0	COG0425@1|root,arCOG02062@2157|Archaea,41SU5@651137|Thaumarchaeota	651137|Thaumarchaeota	O	redox protein, regulator of disulfide bond formation	-	-	-	-	-	-	-	-	-	-	-	-	TusA
TLS1_k127_233413_1	1459636.NTE_02238	3.715e-154	492.0	COG0031@1|root,arCOG01430@2157|Archaea,41SYM@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Cysteine synthase	-	-	2.5.1.47	ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS1_k127_233413_0	1459636.NTE_02240	1.142e-158	505.0	COG0492@1|root,arCOG01296@2157|Archaea,41S97@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TLS1_k127_2335795_0	1459636.NTE_01626	3.986e-159	511.0	COG3243@1|root,arCOG06344@2157|Archaea,41SEX@651137|Thaumarchaeota	651137|Thaumarchaeota	I	TIGRFAM poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit	-	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
TLS1_k127_2335795_1	1459636.NTE_01035	3.234e-134	434.0	COG0640@1|root,COG1809@1|root,arCOG00394@2157|Archaea,arCOG04896@2157|Archaea	2157|Archaea	K	PFAM (2R)-phospho-3-sulfolactate synthase ComA	comA	GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0050545	4.4.1.19	ko:K08097	ko00680,ko01120,map00680,map01120	M00358	R07476	RC01799	ko00000,ko00001,ko00002,ko01000	-	-	-	ComA
TLS1_k127_2335795_2	1459636.NTE_01333	1.038e-26	115.0	arCOG08708@1|root,arCOG08708@2157|Archaea,41SPK@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_2339100_1	1459636.NTE_01960	3.323e-130	419.0	COG1830@1|root,arCOG04044@2157|Archaea,41SCP@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids	aroA'	-	2.2.1.10,4.1.2.13	ko:K16306	ko00010,ko00030,ko00051,ko00400,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00400,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001	R01068,R01070,R02568,R08568	RC00438,RC00439,RC00721,RC02301	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
TLS1_k127_2339100_0	1459636.NTE_02917	1.332e-177	563.0	COG0372@1|root,arCOG04237@2157|Archaea,41SAN@651137|Thaumarchaeota	651137|Thaumarchaeota	C	TIGRFAM 2-methylcitrate synthase citrate synthase II	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
TLS1_k127_2339100_3	1459636.NTE_01897	6.092e-43	165.0	COG2016@1|root,arCOG00985@2157|Archaea,41SSC@651137|Thaumarchaeota	651137|Thaumarchaeota	J	PUA domain	-	-	-	ko:K07575	-	-	-	-	ko00000	-	-	-	PUA
TLS1_k127_2339100_2	1459636.NTE_01466	2.86e-44	169.0	arCOG03727@1|root,arCOG03727@2157|Archaea,41STD@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Mrr_cat
TLS1_k127_2342399_1	1459636.NTE_02976	2.856e-68	237.0	COG0017@1|root,arCOG00407@2157|Archaea	2157|Archaea	J	PFAM tRNA synthetase, class II (D, K and N)	asnS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
TLS1_k127_2342399_0	1459636.NTE_01196	6.041e-108	355.0	COG4742@1|root,arCOG04362@2157|Archaea,41SGE@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
TLS1_k127_2357450_2	1459636.NTE_00777	6.272e-37	148.0	COG1258@1|root,arCOG01015@2157|Archaea,41SHC@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs	-	-	5.4.99.25	ko:K07583	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	-
TLS1_k127_2357450_0	529709.PYCH_02220	1.573e-132	436.0	COG0541@1|root,arCOG01228@2157|Archaea,2XTWX@28890|Euryarchaeota,24377@183968|Thermococci	183968|Thermococci	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	srp54	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
TLS1_k127_2357450_1	1459636.NTE_00775	4.844e-67	235.0	COG2102@1|root,arCOG00035@2157|Archaea,41SHD@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Diphthamide synthase	-	-	6.3.1.14	ko:K06927	-	-	R03613	RC00358	ko00000,ko01000,ko03012	-	-	-	Diphthami_syn_2
TLS1_k127_2357450_3	1386089.N865_07330	8.467e-27	110.0	COG1472@1|root,COG1472@2|Bacteria,2GJ5H@201174|Actinobacteria,4FFSY@85021|Intrasporangiaceae	201174|Actinobacteria	G	Fibronectin type III-like domain	bglS	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
TLS1_k127_2357450_4	1292034.OR37_04139	0.0005102	43.0	COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,2TS28@28211|Alphaproteobacteria,2KHXB@204458|Caulobacterales	204458|Caulobacterales	G	PFAM glycoside hydrolase family 3 domain protein	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
TLS1_k127_238843_1	1459636.NTE_03208	9.749e-140	448.0	COG0464@1|root,arCOG01308@2157|Archaea,41SB6@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
TLS1_k127_238843_0	1459636.NTE_00110	0.0	1434.0	COG0209@1|root,arCOG01917@1|root,arCOG03713@1|root,arCOG01917@2157|Archaea,arCOG03713@2157|Archaea,arCOG04276@2157|Archaea,41SAH@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
TLS1_k127_238843_2	1459636.NTE_01100	2.739e-116	374.0	arCOG08699@1|root,arCOG08699@2157|Archaea,41S8N@651137|Thaumarchaeota	1459636.NTE_01100|-	C	PFAM Ammonia monooxygenase methane monooxygenase, subunit C	-	-	-	ko:K10946	ko00680,ko00910,ko01100,ko01120,ko01200,map00680,map00910,map01100,map01120,map01200	M00174,M00528,M00804	R00148,R09518	RC00173,RC02797	ko00000,ko00001,ko00002	-	-	-	-
TLS1_k127_238843_3	1459636.NTE_00109	2.064e-08	58.0	COG0640@1|root,COG1328@1|root,arCOG00734@2157|Archaea,arCOG04889@2157|Archaea,41SBG@651137|Thaumarchaeota	651137|Thaumarchaeota	FK	Anaerobic ribonucleoside-triphosphate reductase	-	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,HTH_20,NRDD
TLS1_k127_2388877_0	671143.DAMO_2372	2.497e-95	331.0	COG0778@1|root,COG0778@2|Bacteria,2NPP2@2323|unclassified Bacteria	2|Bacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS1_k127_2417196_1	1459636.NTE_00658	1.573e-27	114.0	arCOG10584@1|root,arCOG10584@2157|Archaea,41SV6@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Bacterial Fe(2+) trafficking	-	-	-	-	-	-	-	-	-	-	-	-	Iron_traffic
TLS1_k127_2417196_2	1459636.NTE_02865	1.255e-13	72.0	arCOG10406@1|root,arCOG10406@2157|Archaea,41SVU@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Zinc finger, C2H2 type	-	-	-	-	-	-	-	-	-	-	-	-	zf-C2H2
TLS1_k127_2417196_0	1459636.NTE_02867	1.808e-42	158.0	COG0347@1|root,arCOG02305@2157|Archaea	2157|Archaea	K	Belongs to the P(II) protein family	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	DUF2226,P-II
TLS1_k127_2434338_0	1459636.NTE_02863	4.682e-68	241.0	arCOG03534@1|root,arCOG03534@2157|Archaea	2157|Archaea	S	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS1_k127_2434338_1	1459636.NTE_02647	4.881e-43	166.0	COG1051@1|root,arCOG01075@2157|Archaea	2157|Archaea	F	Nudix hydrolase	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
TLS1_k127_2451735_2	1278073.MYSTI_00289	4.636e-34	138.0	COG0025@1|root,COG0025@2|Bacteria	2|Bacteria	P	sodium:proton antiporter activity	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger,zf-UBP
TLS1_k127_2451735_1	1459636.NTE_01151	1.117e-72	250.0	arCOG06256@1|root,arCOG06256@2157|Archaea	2157|Archaea	S	phospholipase Carboxylesterase	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2
TLS1_k127_2451735_0	1459636.NTE_01150	2.143e-140	453.0	COG0346@1|root,arCOG03101@2157|Archaea	2157|Archaea	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	-	ko:K15975	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS1_k127_2451735_4	485913.Krac_8820	4.524e-21	96.0	COG2146@1|root,COG2146@2|Bacteria,2G7AG@200795|Chloroflexi	200795|Chloroflexi	P	PFAM Rieske 2Fe-2S domain protein	-	-	1.7.1.15	ko:K00363,ko:K05710	ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220	M00530,M00545	R00787,R06782,R06783	RC00098,RC00176	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske
TLS1_k127_2485631_1	1459636.NTE_02002	3.093e-29	119.0	arCOG10524@1|root,arCOG10524@2157|Archaea,41SVP@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_2485631_0	1459636.NTE_01534	9.344e-106	359.0	COG0389@1|root,COG1801@1|root,arCOG04291@2157|Archaea,arCOG04582@2157|Archaea,41SDV@651137|Thaumarchaeota	2157|Archaea	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis	dbh	-	2.7.7.7	ko:K04479	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
TLS1_k127_2548149_0	1459636.NTE_01998	2.382e-59	210.0	COG0778@1|root,arCOG00288@2157|Archaea	2157|Archaea	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS1_k127_2548149_1	1459636.NTE_01932	8.982e-28	116.0	COG2133@1|root,arCOG02796@2157|Archaea	1459636.NTE_01932|-	G	COG2133 Glucose sorbosone dehydrogenases	-	-	-	ko:K21430	-	-	-	-	ko00000,ko01000	-	-	-	-
TLS1_k127_2553613_0	1459636.NTE_03295	2.409e-106	352.0	COG0455@1|root,arCOG00589@2157|Archaea	2157|Archaea	D	COG0455 ATPases involved in chromosome partitioning	-	-	-	ko:K03496,ko:K03609	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
TLS1_k127_2553613_1	1459636.NTE_01491	4.592e-20	94.0	COG0784@1|root,arCOG02391@2157|Archaea	1459636.NTE_01491|-	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_2579447_1	1459636.NTE_03320	1.328e-31	124.0	COG2146@1|root,arCOG02852@2157|Archaea	2157|Archaea	P	COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases	-	-	1.7.1.15	ko:K00363,ko:K15762	ko00623,ko00910,ko00920,ko01100,ko01120,ko01220,map00623,map00910,map00920,map01100,map01120,map01220	M00530,M00538	R00787,R02550,R03562,R05666,R09513	RC00176,RC00269,RC00490,RC02556	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,Rieske_2
TLS1_k127_2579447_0	1459636.NTE_03319	2.188e-153	495.0	COG0215@1|root,arCOG00486@2157|Archaea,41SEW@651137|Thaumarchaeota	651137|Thaumarchaeota	J	PFAM tRNA synthetases class I (C) catalytic domain	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
TLS1_k127_259007_3	1459636.NTE_03322	2.179e-39	151.0	COG0499@1|root,arCOG04137@2157|Archaea,41S9I@651137|Thaumarchaeota	651137|Thaumarchaeota	H	S-adenosyl-L-homocysteine hydrolase, NAD binding domain	-	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
TLS1_k127_259007_4	1459636.NTE_02063	2.488e-14	79.0	arCOG08689@1|root,arCOG08689@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_259007_0	1459636.NTE_03319	1.196e-167	539.0	COG0215@1|root,arCOG00486@2157|Archaea,41SEW@651137|Thaumarchaeota	651137|Thaumarchaeota	J	PFAM tRNA synthetases class I (C) catalytic domain	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
TLS1_k127_259007_2	1459636.NTE_03320	1.135e-42	158.0	COG2146@1|root,arCOG02852@2157|Archaea	2157|Archaea	P	COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases	-	-	1.7.1.15	ko:K00363,ko:K15762	ko00623,ko00910,ko00920,ko01100,ko01120,ko01220,map00623,map00910,map00920,map01100,map01120,map01220	M00530,M00538	R00787,R02550,R03562,R05666,R09513	RC00176,RC00269,RC00490,RC02556	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,Rieske_2
TLS1_k127_259007_1	1459636.NTE_01903	1.159e-75	257.0	COG3620@1|root,arCOG00608@2157|Archaea,41SJR@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HTH_3
TLS1_k127_2607016_1	1541959.KQ51_01145	1.249e-08	59.0	COG0503@1|root,COG0503@2|Bacteria,3WTCR@544448|Tenericutes	544448|Tenericutes	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
TLS1_k127_2607016_0	1459636.NTE_00645	3.028e-279	863.0	COG2368@1|root,arCOG02143@2157|Archaea,41SA0@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	Vinylacetyl-CoA Delta-isomerase	-	-	4.2.1.120,5.3.3.3	ko:K14534	ko00650,ko00720,ko01100,ko01120,ko01200,map00650,map00720,map01100,map01120,map01200	M00374,M00375	R03031,R10782	RC01857,RC03277	ko00000,ko00001,ko00002,ko01000	-	-	-	HpaB,HpaB_N
TLS1_k127_2617283_0	1459636.NTE_02407	9.065e-280	877.0	COG1331@1|root,arCOG02007@2157|Archaea,41SHZ@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
TLS1_k127_2829314_3	1459636.NTE_00604	1.017e-05	47.0	COG0260@1|root,arCOG04322@2157|Archaea,41SYD@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
TLS1_k127_2829314_0	1459636.NTE_00607	2.273e-296	918.0	COG1245@1|root,arCOG00187@2157|Archaea,41S8K@651137|Thaumarchaeota	651137|Thaumarchaeota	E	RNase L inhibitor, RLI	-	-	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,RLI
TLS1_k127_2829314_2	1131266.ARWQ01000015_gene747	6.193e-15	77.0	COG2520@1|root,arCOG00033@2157|Archaea,41S7P@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Met-10+ like-protein	-	-	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
TLS1_k127_2864372_0	1459636.NTE_03552	8.715e-109	361.0	COG0123@1|root,arCOG00324@2157|Archaea	2157|Archaea	BQ	including yeast histone deacetylase and acetoin utilization protein	-	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
TLS1_k127_2936476_2	1459636.NTE_02166	5.248e-30	126.0	arCOG11431@1|root,arCOG11431@2157|Archaea,41T8G@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_2936476_0	1131266.ARWQ01000001_gene1236	3.111e-76	264.0	COG0367@1|root,arCOG00071@2157|Archaea,41SXI@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase
TLS1_k127_2965770_0	1459636.NTE_01702	1.36e-138	447.0	COG0379@1|root,arCOG04459@2157|Archaea,41S6Y@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
TLS1_k127_2965770_1	1459636.NTE_01699	8.615e-19	86.0	COG4919@1|root,arCOG04293@2157|Archaea,41SVI@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Ribosomal protein S30	-	-	-	ko:K02983	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04121	-	-	-	Ribosomal_S30
TLS1_k127_2983731_3	1459636.NTE_02233	7.32e-35	134.0	COG0560@1|root,arCOG01158@2157|Archaea,41SHX@651137|Thaumarchaeota	651137|Thaumarchaeota	E	phosphoserine phosphatase	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD
TLS1_k127_2983731_2	1459636.NTE_01639	4.086e-37	141.0	arCOG07440@1|root,arCOG07440@2157|Archaea,41STP@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_2983731_0	1459636.NTE_01640	4.093e-198	627.0	COG0008@1|root,arCOG00402@2157|Archaea,41SFI@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
TLS1_k127_2983731_1	1459636.NTE_01641	2.152e-77	265.0	arCOG03119@1|root,arCOG03119@2157|Archaea,41SMJ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TLS1_k127_3007762_1	1459636.NTE_02325	8.541e-106	346.0	COG0638@1|root,arCOG00970@2157|Archaea,41T1N@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	-	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
TLS1_k127_3007762_0	1459636.NTE_02326	9.434e-224	701.0	COG0065@1|root,arCOG01698@2157|Archaea,41SYT@651137|Thaumarchaeota	651137|Thaumarchaeota	E	3-isopropylmalate dehydratase, large subunit	-	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
TLS1_k127_3007762_2	1229909.NSED_02200	3.075e-07	52.0	COG0066@1|root,arCOG02230@2157|Archaea,41T1U@651137|Thaumarchaeota	651137|Thaumarchaeota	E	3-isopropylmalate dehydratase, small subunit	-	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
TLS1_k127_3071028_5	1459636.NTE_02729	2.063e-38	146.0	COG0347@1|root,arCOG02305@2157|Archaea,41TB5@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Belongs to the P(II) protein family	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
TLS1_k127_3071028_1	1459636.NTE_02728	1.668e-184	589.0	COG0433@1|root,arCOG00280@2157|Archaea	2157|Archaea	I	COG0433 Predicted ATPase	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853,DUF87
TLS1_k127_3071028_2	1459636.NTE_02727	1.006e-72	258.0	COG1630@1|root,arCOG00367@2157|Archaea	2157|Archaea	S	PFAM NurA domain	-	-	-	-	-	-	-	-	-	-	-	-	NurA
TLS1_k127_3071028_0	1459636.NTE_02820	3.341e-197	623.0	COG0017@1|root,arCOG00406@2157|Archaea,41SBT@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	-	-	6.1.1.23	ko:K09759	ko00970,map00970	M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
TLS1_k127_3071028_6	1459636.NTE_02819	2.531e-20	93.0	COG0721@1|root,arCOG02726@2157|Archaea	2157|Archaea	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
TLS1_k127_3084940_1	436308.Nmar_1268	3.257e-139	449.0	COG0646@1|root,arCOG08715@2157|Archaea,41SWZ@651137|Thaumarchaeota	651137|Thaumarchaeota	E	homocysteine S-methyltransferase	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
TLS1_k127_3084940_0	1459636.NTE_02986	1.7e-321	998.0	COG0294@1|root,COG1410@1|root,arCOG01978@2157|Archaea,arCOG02029@2157|Archaea,41SXT@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Methionine synthase	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind
TLS1_k127_3089657_1	1459636.NTE_01413	8.777e-106	349.0	COG0371@1|root,arCOG00982@2157|Archaea,41T0B@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea	egsA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
TLS1_k127_3089657_0	1459636.NTE_01415	6.693e-121	398.0	COG1782@1|root,arCOG00543@2157|Archaea,41T05@651137|Thaumarchaeota	651137|Thaumarchaeota	S	RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_7,Lactamase_B_6,RMMBL
TLS1_k127_3103145_2	1131266.ARWQ01000005_gene854	8.333e-10	64.0	COG0722@1|root,arCOG00245@2157|Archaea,41SM0@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Prephenate dehydrogenase	-	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
TLS1_k127_3103145_1	1459636.NTE_02299	4.794e-101	339.0	COG2835@1|root,arCOG01792@1|root,arCOG01792@2157|Archaea,arCOG04124@2157|Archaea,41T4S@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3103145_0	1459636.NTE_01112	1.249e-125	406.0	COG0059@1|root,arCOG04465@2157|Archaea,41S65@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
TLS1_k127_3141219_3	1459636.NTE_03303	2.908e-13	72.0	COG1936@1|root,arCOG01038@2157|Archaea,41SPH@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates	-	-	2.7.4.3	ko:K18532	ko00230,ko01100,ko01110,ko01130,ko03008,map00230,map01100,map01110,map01130,map03008	M00049	R00127,R01547	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	AAA_18
TLS1_k127_3141219_0	1459636.NTE_03312	2.101e-102	340.0	arCOG02703@1|root,arCOG02703@2157|Archaea	2157|Archaea	S	Methyltransferase type 11	aknG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
TLS1_k127_3141219_2	1459636.NTE_03311	1.56e-36	138.0	arCOG08782@1|root,arCOG08782@2157|Archaea,41SVH@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3141219_1	1459636.NTE_03310	1.22e-62	214.0	COG1145@1|root,arCOG00291@2157|Archaea,41SNB@651137|Thaumarchaeota	651137|Thaumarchaeota	C	NADH ubiquinone oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
TLS1_k127_3141737_0	1459636.NTE_03025	0.0	1341.0	COG0060@1|root,arCOG00807@2157|Archaea,41SFF@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
TLS1_k127_3141737_3	1459636.NTE_03026	7.613e-32	128.0	arCOG08645@1|root,arCOG08645@2157|Archaea,41STW@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3141737_2	1459636.NTE_02478	1.504e-36	141.0	COG0836@1|root,arCOG02427@2157|Archaea	2157|Archaea	M	TIGRFAM Mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase	manC	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0229	MannoseP_isomer,NTP_transferase
TLS1_k127_3141737_1	1459636.NTE_02856	8.369e-107	348.0	COG5256@1|root,arCOG01561@2157|Archaea,41SD2@651137|Thaumarchaeota	651137|Thaumarchaeota	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
TLS1_k127_3156611_0	1459636.NTE_01473	1.13e-184	578.0	COG1405@1|root,arCOG01981@2157|Archaea,41SXZ@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	-	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
TLS1_k127_3156611_2	1459636.NTE_01470	2.691e-51	182.0	COG0023@1|root,arCOG04223@2157|Archaea,41SNU@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the SUI1 family	-	-	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
TLS1_k127_3156611_3	1459636.NTE_01468	1.821e-19	89.0	COG4023@1|root,arCOG02957@2157|Archaea,41SUS@651137|Thaumarchaeota	651137|Thaumarchaeota	U	Sec61beta family	-	-	-	-	-	-	-	-	-	-	-	-	Sec61_beta
TLS1_k127_3156611_1	1459636.NTE_01467	1.088e-138	462.0	COG3356@1|root,arCOG04351@2157|Archaea,41S7S@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Predicted membrane protein (DUF2070)	-	-	-	ko:K08979	-	-	-	-	ko00000	-	-	-	DUF2070
TLS1_k127_3158482_1	521011.Mpal_1109	2.638e-35	135.0	COG5646@1|root,arCOG09457@2157|Archaea,2Y6W7@28890|Euryarchaeota,2NAY6@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
TLS1_k127_3158482_3	1459636.NTE_00738	0.0001562	45.0	arCOG10856@1|root,arCOG10856@2157|Archaea	1459636.NTE_00738|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3158482_0	1255043.TVNIR_3515	5.816e-81	273.0	COG0262@1|root,COG0262@2|Bacteria,1R5UU@1224|Proteobacteria,1SEMI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS1_k127_3168280_0	1459636.NTE_03272	2.688e-146	471.0	COG1527@1|root,arCOG02459@2157|Archaea,41T18@651137|Thaumarchaeota	651137|Thaumarchaeota	C	ATP synthase (C/AC39) subunit	-	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
TLS1_k127_3168280_2	1459636.NTE_03267	1.202e-12	73.0	arCOG10411@1|root,arCOG10411@2157|Archaea,41T7X@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3175475_4	1459636.NTE_00649	2.997e-05	47.0	COG2237@1|root,arCOG04151@2157|Archaea,41SA3@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Domain of unknown function (DUF373)	-	-	-	ko:K08975	-	-	-	-	ko00000	-	-	-	DUF373
TLS1_k127_3175475_2	1459636.NTE_00631	1.197e-29	120.0	COG2412@1|root,arCOG04051@2157|Archaea,41SS6@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function (DUF424)	-	-	-	ko:K09148	-	-	-	-	ko00000	-	-	-	DUF424
TLS1_k127_3175475_1	1459636.NTE_00633	7.277e-51	188.0	COG1094@1|root,arCOG04150@2157|Archaea,41SNG@651137|Thaumarchaeota	651137|Thaumarchaeota	J	K homology RNA-binding domain	-	-	-	ko:K06961	-	-	-	-	ko00000,ko03009	-	-	-	KH_1
TLS1_k127_3175475_0	1459636.NTE_00635	2.003e-68	237.0	COG0163@1|root,arCOG01703@2157|Archaea,41SHU@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
TLS1_k127_3175475_3	1459636.NTE_00636	1.106e-14	76.0	COG0524@1|root,arCOG00014@2157|Archaea,41SX4@651137|Thaumarchaeota	651137|Thaumarchaeota	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
TLS1_k127_31822_2	1459636.NTE_02923	2.452e-78	268.0	COG2226@1|root,arCOG04348@2157|Archaea,41SGQ@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	ubiE/COQ5 methyltransferase family	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
TLS1_k127_31822_0	1459636.NTE_01631	0.0	1060.0	COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,41S7I@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Succinyl-CoA ligase like flavodoxin domain	-	-	-	ko:K18594	ko00720,ko01120,map00720,map01120	-	R03157	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
TLS1_k127_31822_3	1459636.NTE_02622	3.404e-62	216.0	COG0316@1|root,arCOG04560@2157|Archaea,41SKH@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Iron-sulfur cluster assembly accessory protein	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
TLS1_k127_31822_1	1459636.NTE_02631	3.305e-111	363.0	COG0334@1|root,arCOG01352@2157|Archaea,41S7T@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
TLS1_k127_3206428_0	1459636.NTE_00800	1.14e-285	882.0	COG0480@1|root,arCOG01559@2157|Archaea,41S9B@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
TLS1_k127_3264388_1	1459636.NTE_00055	1.096e-37	145.0	COG1733@1|root,arCOG01057@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
TLS1_k127_3264388_0	1173023.KE650771_gene2491	1.482e-56	205.0	COG2890@1|root,COG2890@2|Bacteria,1GQW3@1117|Cyanobacteria	1117|Cyanobacteria	J	Thiopurine S-methyltransferase (TPMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,TPMT
TLS1_k127_3264388_2	1459636.NTE_02704	7.16e-22	96.0	arCOG08662@1|root,arCOG08662@2157|Archaea,41SQG@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3280674_0	1459636.NTE_01339	5.391e-94	316.0	COG1500@1|root,arCOG04187@2157|Archaea,41SC7@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Shwachman-Bodian-Diamond syndrome (SBDS) protein	-	-	-	ko:K14574	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	SBDS,SBDS_C
TLS1_k127_3280674_1	1459636.NTE_01342	7.898e-80	267.0	COG1097@1|root,arCOG00678@2157|Archaea,41SHV@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome	rrp4	-	-	ko:K03679	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	KH_1
TLS1_k127_3294537_1	1459636.NTE_02800	6.42e-103	339.0	COG0039@1|root,arCOG00246@2157|Archaea,41S7Z@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Belongs to the LDH MDH superfamily	-	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
TLS1_k127_3294537_0	1459636.NTE_02780	1.442e-112	376.0	COG1641@1|root,arCOG02701@2157|Archaea,41SDC@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function DUF111	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
TLS1_k127_3294537_2	1459636.NTE_02779	3.386e-89	302.0	COG1606@1|root,arCOG00043@2157|Archaea,41SF3@651137|Thaumarchaeota	651137|Thaumarchaeota	S	tRNA methyl transferase	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	QueC
TLS1_k127_3294537_3	1459636.NTE_02778	4.88e-25	106.0	COG1104@1|root,arCOG00066@2157|Archaea,41SB1@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Cysteine desulfurase	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
TLS1_k127_3326850_1	1459636.NTE_00424	1.243e-37	142.0	COG0174@1|root,arCOG01909@2157|Archaea,41SD6@651137|Thaumarchaeota	651137|Thaumarchaeota	E	TIGRFAM glutamine synthetase, type I	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
TLS1_k127_3326850_0	1459636.NTE_02931	1.507e-190	604.0	COG0015@1|root,arCOG01747@2157|Archaea,41SD1@651137|Thaumarchaeota	651137|Thaumarchaeota	F	adenylosuccinate lyase	-	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
TLS1_k127_3326850_2	1459636.NTE_00858	8.356e-23	98.0	COG0367@1|root,arCOG00071@2157|Archaea,41SIX@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase
TLS1_k127_3350231_1	1131266.ARWQ01000001_gene1220	9.64e-131	427.0	COG0476@1|root,COG1977@1|root,arCOG00536@2157|Archaea,arCOG01676@2157|Archaea,41S5X@651137|Thaumarchaeota	651137|Thaumarchaeota	H	ThiF family	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF,ThiS
TLS1_k127_3350231_0	1459636.NTE_00076	1.522e-167	529.0	COG0498@1|root,arCOG01434@2157|Archaea,41SEI@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS1_k127_3352754_1	1459636.NTE_01391	1.162e-67	234.0	COG1234@1|root,arCOG00501@2157|Archaea,41SF7@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B,Lactamase_B_2
TLS1_k127_3352754_0	1459636.NTE_01761	1.289e-100	333.0	COG1032@1|root,arCOG01363@2157|Archaea,41S6P@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS1_k127_3383879_1	1459636.NTE_01697	3.262e-16	81.0	COG3269@1|root,arCOG01641@2157|Archaea	2157|Archaea	J	RNA-binding protein contains TRAM domain	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
TLS1_k127_3383879_0	262724.TT_C1879	6.278e-73	267.0	COG0433@1|root,COG0433@2|Bacteria,1WME2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	COG0433 Predicted ATPase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3436368_0	1459636.NTE_02127	5.381e-95	317.0	COG2047@1|root,arCOG00348@2157|Archaea	2157|Archaea	S	protein (ATP-grasp superfamily)	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
TLS1_k127_3453382_1	1459636.NTE_01820	1.664e-63	223.0	COG0642@1|root,arCOG02358@2157|Archaea,41T5G@651137|Thaumarchaeota	651137|Thaumarchaeota	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,dCache_1
TLS1_k127_3453382_0	1459636.NTE_01492	1.902e-79	277.0	COG0642@1|root,arCOG02358@2157|Archaea,41T5G@651137|Thaumarchaeota	651137|Thaumarchaeota	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,dCache_1
TLS1_k127_3453382_2	1459636.NTE_01491	8.626e-20	93.0	COG0784@1|root,arCOG02391@2157|Archaea	1459636.NTE_01491|-	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3472240_0	1459636.NTE_02585	2.279e-121	397.0	arCOG03562@1|root,arCOG03562@2157|Archaea,41SY7@651137|Thaumarchaeota	1459636.NTE_02585|-	O	AhpC/TSA family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3472240_1	1459636.NTE_02579	9.016e-05	44.0	COG0644@1|root,arCOG00570@2157|Archaea,41S82@651137|Thaumarchaeota	651137|Thaumarchaeota	C	geranylgeranyl reductase	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_oxidored,Trp_halogenase
TLS1_k127_3511588_3	1459636.NTE_01247	1.098e-20	93.0	COG0667@1|root,arCOG01617@2157|Archaea,41S90@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS1_k127_3511588_0	1459636.NTE_01248	7.186e-148	475.0	COG1522@1|root,arCOG01628@2157|Archaea,41SA2@651137|Thaumarchaeota	651137|Thaumarchaeota	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3511588_2	1459636.NTE_01258	1.549e-21	101.0	arCOG08663@1|root,arCOG08663@2157|Archaea,41SR2@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3511588_1	1459636.NTE_01259	2.962e-66	229.0	arCOG08664@1|root,arCOG08664@2157|Archaea,41SKM@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3532970_4	1459636.NTE_03525	1.646e-54	194.0	COG3794@1|root,arCOG02926@2157|Archaea,41SPG@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM Copper binding proteins, plastocyanin azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind
TLS1_k127_3532970_8	1459636.NTE_01575	3.797e-28	117.0	arCOG08633@1|root,arCOG08633@2157|Archaea,41SUK@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3532970_2	1459636.NTE_01571	1.818e-85	291.0	COG0596@1|root,arCOG01653@2157|Archaea	2157|Archaea	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS1_k127_3532970_9	1459636.NTE_01570	4.479e-25	107.0	arCOG03937@1|root,arCOG03937@2157|Archaea,41SWM@651137|Thaumarchaeota	651137|Thaumarchaeota	K	COG2002 Regulators of stationary sporulation gene expression	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3532970_6	1459636.NTE_01627	2.607e-30	127.0	arCOG06343@1|root,arCOG06343@2157|Archaea,41SRX@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E)	-	-	-	-	-	-	-	-	-	-	-	-	PHA_synth_III_E
TLS1_k127_3532970_1	1459636.NTE_00711	5.438e-86	289.0	COG0081@1|root,arCOG04289@2157|Archaea,41SHF@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Binds directly to 23S rRNA. Probably involved in E site tRNA release	rpl1	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
TLS1_k127_3532970_0	1459636.NTE_00712	6.701e-103	343.0	COG0244@1|root,arCOG04288@2157|Archaea,41S9R@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl10	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
TLS1_k127_3532970_7	1459636.NTE_00715	4.869e-30	122.0	COG2058@1|root,arCOG04287@2157|Archaea,41SP0@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl12	-	-	ko:K02869	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s
TLS1_k127_3532970_5	1459636.NTE_01274	2.14e-53	192.0	arCOG08745@1|root,arCOG08745@2157|Archaea,41SU1@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3532970_3	1459636.NTE_01277	1.455e-71	244.0	COG1522@1|root,arCOG01580@2157|Archaea,41SJD@651137|Thaumarchaeota	651137|Thaumarchaeota	K	helix_turn_helix ASNC type	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24
TLS1_k127_3532970_11	1131266.ARWQ01000002_gene505	6.976e-16	79.0	COG1759@1|root,arCOG04346@2157|Archaea,41SBR@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates	purP	-	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
TLS1_k127_3547086_0	383372.Rcas_1750	7.454e-63	231.0	COG0265@1|root,COG0265@2|Bacteria,2G6KG@200795|Chloroflexi,3768V@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S1 and S6, chymotrypsin Hap	-	-	1.3.1.74	ko:K08070	-	-	-	-	ko00000,ko01000	-	-	-	PDZ_2,Trypsin_2
TLS1_k127_3562266_1	1459636.NTE_02122	3.566e-65	229.0	COG1744@1|root,arCOG00257@2157|Archaea	2157|Archaea	S	ABC-type transport system, periplasmic component surface lipoprotein	-	-	-	ko:K02058,ko:K07335	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
TLS1_k127_3562266_0	1009370.ALO_13095	5.769e-98	341.0	COG0074@1|root,COG0074@2|Bacteria,1TPIT@1239|Firmicutes,4H2I1@909932|Negativicutes	909932|Negativicutes	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
TLS1_k127_3562266_3	1499967.BAYZ01000016_gene6506	0.0001548	46.0	COG0074@1|root,COG0074@2|Bacteria,2NQG1@2323|unclassified Bacteria	2|Bacteria	C	Protein of unknown function (DUF1116)	sucD	-	6.2.1.5	ko:K01902,ko:K02381	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,DUF1116,Ligase_CoA
TLS1_k127_3562266_2	669262.COK_0919	3.116e-08	65.0	2EIHP@1|root,33C91@2|Bacteria,1R3BH@1224|Proteobacteria,1T663@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2877)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2877
TLS1_k127_3574168_2	1146883.BLASA_1996	2.377e-07	54.0	COG5466@1|root,COG5466@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1059)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1059
TLS1_k127_3574168_1	1459636.NTE_02662	9.412e-113	369.0	COG0175@1|root,arCOG00124@2157|Archaea,41S9Q@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Phosphoadenosine phosphosulfate reductase family	-	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
TLS1_k127_3574168_0	1459636.NTE_02663	1.234e-124	405.0	COG2046@1|root,arCOG04191@2157|Archaea,41SER@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Belongs to the sulfate adenylyltransferase family	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
TLS1_k127_3624197_0	1459636.NTE_00079	3.09e-262	823.0	COG1933@1|root,arCOG04447@2157|Archaea,41SYW@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	PolC_DP2
TLS1_k127_3670224_1	1459636.NTE_01485	0.0002197	47.0	COG3432@1|root,arCOG01055@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
TLS1_k127_3670224_0	1459636.NTE_02203	1.622e-25	106.0	COG2406@1|root,arCOG01093@2157|Archaea	2157|Archaea	S	COG2406 Protein distantly related to bacterial ferritins	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
TLS1_k127_3694369_0	203908.EGF98352	1.104e-09	70.0	COG1112@1|root,KOG1805@2759|Eukaryota,38C48@33154|Opisthokonta,3NVHU@4751|Fungi,3UZ5E@5204|Basidiomycota,2YCF4@29000|Pucciniomycotina	4751|Fungi	L	AAA domain	dna2	GO:0000003,GO:0000014,GO:0000166,GO:0000228,GO:0000278,GO:0000706,GO:0000723,GO:0000729,GO:0000733,GO:0000781,GO:0000784,GO:0001302,GO:0003674,GO:0003678,GO:0003682,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005657,GO:0005694,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006302,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007568,GO:0007569,GO:0008026,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009607,GO:0009719,GO:0009987,GO:0016043,GO:0016070,GO:0016233,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016887,GO:0016888,GO:0016893,GO:0016895,GO:0017076,GO:0017108,GO:0017111,GO:0019439,GO:0019899,GO:0019900,GO:0019901,GO:0022402,GO:0022414,GO:0022616,GO:0030554,GO:0031297,GO:0031860,GO:0031974,GO:0031981,GO:0032200,GO:0032392,GO:0032502,GO:0032508,GO:0032553,GO:0032555,GO:0032559,GO:0033260,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0035312,GO:0035639,GO:0035861,GO:0036094,GO:0042592,GO:0042623,GO:0043137,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043596,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0044786,GO:0045005,GO:0045145,GO:0046483,GO:0046700,GO:0048256,GO:0048869,GO:0050896,GO:0051276,GO:0051321,GO:0051716,GO:0060249,GO:0065007,GO:0065008,GO:0070013,GO:0070035,GO:0071103,GO:0071216,GO:0071495,GO:0071704,GO:0071840,GO:0071932,GO:0072396,GO:0072402,GO:0072423,GO:0072429,GO:0090304,GO:0090305,GO:0090734,GO:0097159,GO:0097367,GO:0098687,GO:0140097,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901576,GO:1902969,GO:1903046,GO:1903047,GO:1903461,GO:1903469,GO:1990601	3.6.4.12	ko:K10742	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	AAA_11,AAA_12,Cas_Cas4,Dna2
TLS1_k127_3715231_1	1459636.NTE_02807	1.03e-43	166.0	COG1896@1|root,arCOG04311@2157|Archaea,41SQE@651137|Thaumarchaeota	651137|Thaumarchaeota	S	HD domain	-	-	-	ko:K07023	-	-	-	-	ko00000	-	-	-	HD_3
TLS1_k127_3715231_0	1459636.NTE_02809	6.873e-199	627.0	COG1915@1|root,arCOG04422@2157|Archaea,41SBQ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	LOR SDH bifunctional	-	-	-	-	-	-	-	-	-	-	-	-	Saccharop_dh_N
TLS1_k127_3716616_0	1459636.NTE_00968	1.303e-157	509.0	COG0677@1|root,arCOG00252@2157|Archaea	2157|Archaea	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	wecC	-	1.1.1.336	ko:K02472	ko00520,ko05111,map00520,map05111	-	R03317	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
TLS1_k127_3722032_0	1459636.NTE_01924	3.476e-66	232.0	COG0558@1|root,arCOG00670@2157|Archaea,41SJ7@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.39	ko:K17884	-	-	R10464	RC00002,RC00078	ko00000,ko01000	-	-	-	CDP-OH_P_transf
TLS1_k127_3722032_1	1459636.NTE_01923	7.297e-48	172.0	COG4830@1|root,arCOG04305@2157|Archaea,41SNM@651137|Thaumarchaeota	651137|Thaumarchaeota	J	ribosomal protein	-	-	-	ko:K02976	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S26e
TLS1_k127_3727469_2	1131266.ARWQ01000001_gene1248	7.625e-26	108.0	arCOG08723@1|root,arCOG08723@2157|Archaea,41SPX@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3727469_0	1459636.NTE_02319	0.0	1092.0	COG1964@1|root,arCOG00933@2157|Archaea,41SAY@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Radical SAM	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
TLS1_k127_3727469_1	1459636.NTE_02318	1.257e-103	342.0	COG1378@1|root,arCOG02038@2157|Archaea,41SFR@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Archaeal transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
TLS1_k127_3735588_0	1459636.NTE_03208	6.632e-73	250.0	COG0464@1|root,arCOG01308@2157|Archaea,41SB6@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
TLS1_k127_3764997_0	1459636.NTE_01021	5.408e-86	300.0	COG0265@1|root,arCOG02833@2157|Archaea,41S9W@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Trypsin-like serine protease with C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
TLS1_k127_3764997_2	264732.Moth_0715	2.644e-19	95.0	arCOG04740@1|root,31PZA@2|Bacteria,1VDV3@1239|Firmicutes,24NCP@186801|Clostridia,42ICC@68295|Thermoanaerobacterales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3764997_1	1459636.NTE_00763	1.581e-66	231.0	COG0596@1|root,arCOG07416@1|root,arCOG01648@2157|Archaea,arCOG07416@2157|Archaea,41SFU@651137|Thaumarchaeota	2157|Archaea	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
TLS1_k127_3783157_0	1459636.NTE_01496	2.411e-147	486.0	COG0642@1|root,arCOG03644@1|root,arCOG02358@2157|Archaea,arCOG03644@2157|Archaea,41T5G@651137|Thaumarchaeota	651137|Thaumarchaeota	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,dCache_1
TLS1_k127_3869493_4	1459636.NTE_01240	5.825e-11	64.0	arCOG08678@1|root,arCOG08678@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3869493_2	1459636.NTE_01335	8.622e-68	232.0	COG0088@1|root,arCOG04243@2157|Archaea,41SKT@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the universal ribosomal protein uS9 family	-	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
TLS1_k127_3869493_1	1459636.NTE_01336	3.228e-68	234.0	COG0102@1|root,arCOG04242@2157|Archaea,41SP4@651137|Thaumarchaeota	651137|Thaumarchaeota	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rpl13	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
TLS1_k127_3869493_3	243232.MJ_0193	4.279e-26	112.0	COG1727@1|root,arCOG00780@2157|Archaea,2XZ6R@28890|Euryarchaeota,23R1N@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eL18 family	rpl18e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02883	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18
TLS1_k127_3869493_0	1459636.NTE_01338	7.614e-95	315.0	COG0202@1|root,arCOG04241@2157|Archaea,41SK0@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-directed RNA polymerase, alpha subunit 40 kD subunit	-	-	2.7.7.6	ko:K03047	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_A_bac,RNA_pol_L
TLS1_k127_3879369_0	1198449.ACAM_1553	9.291e-189	604.0	COG4670@1|root,arCOG01986@2157|Archaea,2XQ55@28889|Crenarchaeota	28889|Crenarchaeota	I	PFAM Coenzyme A transferase	-	-	2.8.3.1	ko:K01026	ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120	-	R00928,R01449,R05508	RC00012,RC00014,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
TLS1_k127_3879369_2	1459636.NTE_01161	6.605e-22	99.0	COG0347@1|root,arCOG02305@2157|Archaea	2157|Archaea	K	Belongs to the P(II) protein family	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	DUF2226,P-II
TLS1_k127_3879369_1	1459636.NTE_01353	7.81e-35	135.0	arCOG08760@1|root,arCOG08760@2157|Archaea,41T7P@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3879369_3	1459636.NTE_01532	1.929e-05	46.0	arCOG08750@1|root,arCOG08750@2157|Archaea	1459636.NTE_01532|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3890581_1	1459636.NTE_02188	3.477e-104	345.0	COG4742@1|root,arCOG04362@2157|Archaea,41SGE@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
TLS1_k127_3890581_0	1459636.NTE_02012	5.521e-217	684.0	COG1782@1|root,arCOG00543@2157|Archaea,41T05@651137|Thaumarchaeota	2157|Archaea	S	RNA-metabolising metallo-beta-lactamase	epf2	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_2,KH_7,Lactamase_B,Lactamase_B_6,RMMBL
TLS1_k127_3892727_1	1459636.NTE_00844	1.292e-19	91.0	COG1335@1|root,arCOG01943@2157|Archaea	2157|Archaea	Q	COG1335 Amidases related to nicotinamidase	-	-	3.5.1.110	ko:K09020	ko00240,ko01100,map00240,map01100	-	R09947,R09980	RC02737,RC02738	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
TLS1_k127_3915056_1	1459636.NTE_01615	4.214e-39	148.0	arCOG08751@1|root,arCOG08751@2157|Archaea,41SS7@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_3915056_0	1459636.NTE_00750	9.487e-119	389.0	COG0111@1|root,arCOG01754@2157|Archaea,41S8U@651137|Thaumarchaeota	651137|Thaumarchaeota	H	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS1_k127_3949428_0	1459636.NTE_01284	3.161e-292	919.0	COG0495@1|root,arCOG00809@2157|Archaea,41SES@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
TLS1_k127_4040080_1	1459636.NTE_02312	4.33e-60	211.0	COG1817@1|root,arCOG01395@2157|Archaea,41S8D@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function (DUF354)	-	-	-	ko:K09726	-	-	-	-	ko00000	-	-	-	DUF354
TLS1_k127_4040080_0	1459636.NTE_02313	9.204e-140	454.0	COG1250@1|root,arCOG00250@2157|Archaea	2157|Archaea	I	3-hydroxyacyl-CoA dehydrogenase	hbd	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
TLS1_k127_4063461_2	234267.Acid_2413	3.087e-05	48.0	COG3212@1|root,COG3212@2|Bacteria	2|Bacteria	T	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	PepSY
TLS1_k127_4063461_0	1463885.KL578392_gene2362	1.731e-47	184.0	COG2234@1|root,COG2234@2|Bacteria,2I9YF@201174|Actinobacteria	201174|Actinobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
TLS1_k127_4063461_1	1168067.JAGP01000001_gene1275	1.238e-17	84.0	COG3118@1|root,COG3118@2|Bacteria,1RHRZ@1224|Proteobacteria,1S8VM@1236|Gammaproteobacteria,462GA@72273|Thiotrichales	72273|Thiotrichales	O	Thioredoxin	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
TLS1_k127_4080844_0	1459636.NTE_01698	3.106e-58	211.0	COG1712@1|root,arCOG00254@2157|Archaea,41SGA@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate	nadX	-	1.4.1.21	ko:K06989	ko00760,ko01100,map00760,map01100	-	R07407,R07410	RC02566	ko00000,ko00001,ko01000	-	-	-	DUF108,NAD_binding_3
TLS1_k127_4080844_2	1459636.NTE_01697	1.022e-34	134.0	COG3269@1|root,arCOG01641@2157|Archaea	2157|Archaea	J	RNA-binding protein contains TRAM domain	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
TLS1_k127_4080844_1	1459636.NTE_01850	1.52e-46	173.0	COG1028@1|root,arCOG01259@2157|Archaea,41S7V@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS1_k127_4114310_0	1459636.NTE_00744	1.402e-145	467.0	COG0657@1|root,arCOG02638@2157|Archaea	2157|Archaea	I	Alpha beta hydrolase	-	-	3.1.1.83	ko:K01066,ko:K14731	ko00903,ko00930,ko01220,map00903,map00930,map01220	-	R03751,R06390,R06391,R06392,R06393	RC00713,RC00983,RC01505	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_3
TLS1_k127_4114310_3	1459636.NTE_01690	5.009e-17	87.0	COG0517@1|root,arCOG00606@2157|Archaea	2157|Archaea	I	CBS domain	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	CBS,TrkH
TLS1_k127_4114310_2	240292.Ava_C0142	2.432e-50	186.0	COG1651@1|root,COG1651@2|Bacteria,1G2ZB@1117|Cyanobacteria,1HP1D@1161|Nostocales	1117|Cyanobacteria	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
TLS1_k127_4123346_0	1459636.NTE_00424	6.307e-238	740.0	COG0174@1|root,arCOG01909@2157|Archaea,41SD6@651137|Thaumarchaeota	651137|Thaumarchaeota	E	TIGRFAM glutamine synthetase, type I	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
TLS1_k127_4123346_1	1459636.NTE_01317	2.341e-181	577.0	COG1171@1|root,arCOG01431@2157|Archaea,41SCU@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS1_k127_4124024_0	1459636.NTE_00377	3.958e-96	316.0	COG1146@1|root,arCOG04548@2157|Archaea,41SI0@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM 4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
TLS1_k127_4124024_3	1459636.NTE_00075	1.307e-45	167.0	COG0139@1|root,arCOG02676@2157|Archaea,41SPE@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19	ko:K01496	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04037	RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH
TLS1_k127_4124024_1	1459636.NTE_00034	5.086e-92	310.0	COG1108@1|root,arCOG01006@2157|Archaea,41SG2@651137|Thaumarchaeota	651137|Thaumarchaeota	P	ABC 3 transport family	-	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
TLS1_k127_4128781_1	1459636.NTE_02012	3.496e-89	296.0	COG1782@1|root,arCOG00543@2157|Archaea,41T05@651137|Thaumarchaeota	2157|Archaea	S	RNA-metabolising metallo-beta-lactamase	epf2	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_2,KH_7,Lactamase_B,Lactamase_B_6,RMMBL
TLS1_k127_4128781_2	1459636.NTE_01851	1.418e-48	183.0	COG0730@1|root,arCOG02050@2157|Archaea,41SKY@651137|Thaumarchaeota	651137|Thaumarchaeota	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS1_k127_4128781_0	1459636.NTE_01853	1.87e-128	417.0	COG0460@1|root,arCOG01351@2157|Archaea,41SAC@651137|Thaumarchaeota	651137|Thaumarchaeota	E	homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	Homoserine_dh,NAD_binding_3
TLS1_k127_413669_0	439235.Dalk_3617	3.744e-09	63.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2MN5K@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM peptidase S1 and S6 chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
TLS1_k127_4156309_5	1500257.JQNM01000010_gene787	8.5e-07	61.0	COG2931@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,4BBNN@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	Cadherin repeats.	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,He_PIG,HemolysinCabind
TLS1_k127_4156309_0	246197.MXAN_4914	7.103e-115	386.0	COG3291@1|root,COG3291@2|Bacteria,1QXUX@1224|Proteobacteria	1224|Proteobacteria	Q	F5/8 type C domain	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_lyase2,F5_F8_type_C
TLS1_k127_4156309_2	1385512.N784_05285	1.276e-38	158.0	COG0458@1|root,COG0458@2|Bacteria,1UIGF@1239|Firmicutes,4IUCV@91061|Bacilli	91061|Bacilli	EF	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3
TLS1_k127_4156309_4	1353531.AZNX01000012_gene3936	5.663e-09	66.0	COG1387@1|root,COG1387@2|Bacteria,1NE2J@1224|Proteobacteria,2V2UI@28211|Alphaproteobacteria,4BJN2@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Histidinol phosphatase and related hydrolases of the PHP family	-	-	-	ko:K04477	-	-	-	-	ko00000	-	-	-	-
TLS1_k127_4156309_3	589924.Ferp_1923	9.503e-25	120.0	arCOG06939@1|root,arCOG06939@2157|Archaea	2157|Archaea	S	WbqC-like protein family	-	-	-	-	-	-	-	-	-	-	-	-	WbqC
TLS1_k127_4156309_1	211165.AJLN01000094_gene1159	3.68e-53	203.0	COG0458@1|root,COG0458@2|Bacteria	2|Bacteria	F	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_3
TLS1_k127_4205802_1	1365176.N186_07020	1.294e-111	374.0	COG3839@1|root,arCOG00175@2157|Archaea,2XPUC@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM ABC transporter related	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
TLS1_k127_4205802_0	1459636.NTE_01495	7.579e-170	544.0	COG1653@1|root,arCOG00151@2157|Archaea	2157|Archaea	G	COG1653 ABC-type sugar transport system, periplasmic component	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
TLS1_k127_4205802_2	403833.Pmob_1491	6.773e-87	296.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	ko:K02025,ko:K05814,ko:K10109,ko:K10189,ko:K15771,ko:K17245,ko:K17316	ko02010,map02010	M00194,M00198,M00199,M00207,M00491,M00601,M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.22,3.A.1.1.24,3.A.1.1.3,3.A.1.1.30,3.A.1.1.4,3.A.1.1.40	-	-	BPD_transp_1
TLS1_k127_4223908_2	436308.Nmar_1581	1.948e-12	76.0	COG2266@1|root,arCOG01871@2157|Archaea,41SRI@651137|Thaumarchaeota	651137|Thaumarchaeota	M	MobA-like NTP transferase domain	-	-	2.7.7.62	ko:K19712	ko00860,ko01100,map00860,map01100	-	R05222	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
TLS1_k127_4223908_1	1459636.NTE_03117	3.596e-62	222.0	COG0368@1|root,arCOG04338@2157|Archaea,41SI6@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
TLS1_k127_4223908_0	1459636.NTE_03116	5.564e-91	308.0	COG1270@1|root,arCOG04274@2157|Archaea,41S6I@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group	cobD	-	6.3.1.10	ko:K02227	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CobD_Cbib
TLS1_k127_4235617_1	1459636.NTE_03130	6.579e-24	105.0	COG0600@1|root,arCOG00169@2157|Archaea,41SIT@651137|Thaumarchaeota	651137|Thaumarchaeota	P	ABC-type nitrate sulfonate bicarbonate transport system, permease component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
TLS1_k127_4235617_0	1459636.NTE_03132	7.176e-101	338.0	COG0715@1|root,arCOG01803@2157|Archaea,41SG5@651137|Thaumarchaeota	651137|Thaumarchaeota	P	TIGRFAM ABC transporter, substrate-binding protein, aliphatic sulfonates family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
TLS1_k127_4259013_1	1459636.NTE_02477	4.822e-68	239.0	COG0317@1|root,arCOG06870@2157|Archaea	2157|Archaea	KT	HD domain	-	-	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	HD_4
TLS1_k127_4259013_0	1459636.NTE_02476	2.952e-117	384.0	COG2086@1|root,arCOG00446@2157|Archaea,41SX2@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
TLS1_k127_4259013_2	1459636.NTE_02475	1.536e-47	174.0	COG2025@1|root,arCOG00448@2157|Archaea,41SZJ@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Electron transfer flavoprotein domain	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
TLS1_k127_4259387_0	1459636.NTE_01500	1.664e-173	552.0	COG0281@1|root,arCOG00853@2157|Archaea	2157|Archaea	C	malic enzyme	maeB	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
TLS1_k127_4264952_0	1459636.NTE_01850	1.263e-134	440.0	COG1028@1|root,arCOG01259@2157|Archaea,41S7V@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS1_k127_4264952_2	1459636.NTE_01764	3.271e-75	256.0	COG1676@1|root,arCOG01701@2157|Archaea,41SHW@651137|Thaumarchaeota	651137|Thaumarchaeota	L	tRNA intron endonuclease, N-terminal domain	-	-	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
TLS1_k127_4264952_1	1459636.NTE_01763	3.868e-82	278.0	COG1392@1|root,arCOG02640@2157|Archaea,41SGI@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
TLS1_k127_4264952_3	1459636.NTE_01853	1.268e-16	79.0	COG0460@1|root,arCOG01351@2157|Archaea,41SAC@651137|Thaumarchaeota	651137|Thaumarchaeota	E	homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	Homoserine_dh,NAD_binding_3
TLS1_k127_4280231_2	1459636.NTE_01015	1.509e-30	130.0	arCOG08733@1|root,arCOG08733@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4280231_1	1459636.NTE_01014	1.779e-47	175.0	arCOG10527@1|root,arCOG10527@2157|Archaea,41SPB@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4280231_0	1459636.NTE_01380	5.565e-70	243.0	arCOG08734@1|root,arCOG08734@2157|Archaea,41SP9@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4280231_3	1459636.NTE_01377	5.664e-30	124.0	arCOG08731@1|root,arCOG08731@2157|Archaea,41STT@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4280231_4	1459636.NTE_01360	2.566e-06	51.0	COG0640@1|root,arCOG00472@2157|Archaea	2157|Archaea	K	PFAM regulatory protein, ArsR	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_16,AAA_22,DUF2791,HTH_5
TLS1_k127_4281737_0	1459636.NTE_02717	1.661e-139	449.0	COG2141@1|root,arCOG02410@2157|Archaea	2157|Archaea	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	fgd-2	-	1.1.98.2,1.1.98.5	ko:K15510,ko:K21835	-	-	-	-	ko00000,ko01000	-	-	-	Bac_luciferase
TLS1_k127_4281737_1	1122962.AULH01000012_gene738	4.123e-12	76.0	COG2931@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,36ZHC@31993|Methylocystaceae	28211|Alphaproteobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,HCBP_related,He_PIG,HemolysinCabind
TLS1_k127_4301358_1	436308.Nmar_1340	5.777e-09	59.0	COG1405@1|root,arCOG01981@2157|Archaea	2157|Archaea	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
TLS1_k127_4301358_0	1459636.NTE_01390	3.838e-81	280.0	COG0639@1|root,arCOG01143@2157|Archaea	2157|Archaea	T	COG0639 Diadenosine tetraphosphatase and related serine threonine protein phosphatases	-	-	3.1.3.16	ko:K01090,ko:K06269	ko03015,ko04022,ko04024,ko04113,ko04114,ko04218,ko04261,ko04270,ko04390,ko04510,ko04611,ko04720,ko04728,ko04750,ko04810,ko04910,ko04921,ko04931,ko05031,ko05034,ko05168,ko05205,map03015,map04022,map04024,map04113,map04114,map04218,map04261,map04270,map04390,map04510,map04611,map04720,map04728,map04750,map04810,map04910,map04921,map04931,map05031,map05034,map05168,map05205	-	-	-	ko00000,ko00001,ko01000,ko01009,ko03019,ko03021,ko03041	-	-	-	Metallophos
TLS1_k127_4301358_2	1094980.Mpsy_2342	5.872e-07	61.0	COG0467@1|root,arCOG01178@2157|Archaea,2Y0GM@28890|Euryarchaeota	28890|Euryarchaeota	T	PFAM GvpD gas vesicle	gvpD	-	-	-	-	-	-	-	-	-	-	-	GvpD
TLS1_k127_4352547_1	1459636.NTE_01912	2.802e-60	214.0	COG0159@1|root,arCOG01086@2157|Archaea,41SG0@651137|Thaumarchaeota	651137|Thaumarchaeota	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
TLS1_k127_4352547_0	1459636.NTE_01913	2.965e-173	552.0	COG0133@1|root,arCOG01433@2157|Archaea,41S87@651137|Thaumarchaeota	651137|Thaumarchaeota	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS1_k127_4352547_2	1459636.NTE_02554	5.114e-20	91.0	COG1143@1|root,arCOG01543@2157|Archaea,41SGW@651137|Thaumarchaeota	651137|Thaumarchaeota	C	4Fe-4S binding domain	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_4
TLS1_k127_4376197_2	1459636.NTE_00948	3.441e-21	100.0	COG1846@1|root,arCOG03177@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR
TLS1_k127_4376197_0	1459636.NTE_01164	8.806e-136	450.0	arCOG00144@1|root,arCOG11894@1|root,arCOG00144@2157|Archaea,arCOG11894@2157|Archaea	2157|Archaea	S	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS1_k127_4403956_0	1459636.NTE_01247	3.348e-142	457.0	COG0667@1|root,arCOG01617@2157|Archaea,41S90@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS1_k127_4403956_3	1459636.NTE_01246	2.715e-50	185.0	COG1715@1|root,arCOG09740@2157|Archaea,41T5F@651137|Thaumarchaeota	651137|Thaumarchaeota	V	Domain of unknown function (DUF1802)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1802
TLS1_k127_4403956_2	1459636.NTE_01245	4.884e-96	319.0	COG3253@1|root,arCOG03031@2157|Archaea,41SGX@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Chlorite dismutase	-	-	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
TLS1_k127_4403956_1	1459636.NTE_01244	8.279e-131	421.0	COG0396@1|root,arCOG04236@2157|Archaea,41SE1@651137|Thaumarchaeota	651137|Thaumarchaeota	O	FeS assembly ATPase SufC	-	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
TLS1_k127_4417685_0	1459636.NTE_01567	2.021e-44	167.0	COG0122@1|root,arCOG00464@2157|Archaea,41SHE@651137|Thaumarchaeota	651137|Thaumarchaeota	L	8-oxoguanine DNA glycosylase	-	-	4.2.99.18	ko:K03660	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
TLS1_k127_4420754_0	264732.Moth_2121	1.951e-127	420.0	COG0074@1|root,COG0074@2|Bacteria,1UJ4F@1239|Firmicutes,24AQG@186801|Clostridia	186801|Clostridia	C	Succinyl-CoA synthetase, alpha subunit	-	-	-	ko:K02381	-	-	-	-	ko00000	-	-	-	CoA_binding,DUF1116,Ligase_CoA
TLS1_k127_4420754_1	391623.TERMP_01794	9.61e-75	262.0	COG0549@1|root,arCOG00863@2157|Archaea,2XTCB@28890|Euryarchaeota,243F1@183968|Thermococci	183968|Thermococci	E	Belongs to the carbamate kinase family	cpkA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
TLS1_k127_4425081_6	1459636.NTE_00433	1.117e-61	218.0	arCOG08765@1|root,arCOG08765@2157|Archaea,41SQJ@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4425081_4	1459636.NTE_00439	3.937e-76	259.0	COG2131@1|root,arCOG01487@2157|Archaea,41SHS@651137|Thaumarchaeota	651137|Thaumarchaeota	F	MafB19-like deaminase	-	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
TLS1_k127_4425081_1	1459636.NTE_01562	2.132e-96	323.0	COG0457@1|root,arCOG03032@2157|Archaea	2157|Archaea	T	PFAM TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_8
TLS1_k127_4425081_2	1459636.NTE_03156	8.741e-83	289.0	COG0677@1|root,arCOG00252@2157|Archaea	2157|Archaea	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.336	ko:K02472	ko00520,ko05111,map00520,map05111	-	R03317	RC00291	ko00000,ko00001,ko01000	-	-	-	NAD_binding_2,UDPG_MGDP_dh,UDPG_MGDP_dh_C
TLS1_k127_4425081_5	1459636.NTE_01924	8.006e-62	219.0	COG0558@1|root,arCOG00670@2157|Archaea,41SJ7@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.39	ko:K17884	-	-	R10464	RC00002,RC00078	ko00000,ko01000	-	-	-	CDP-OH_P_transf
TLS1_k127_4425081_7	1459636.NTE_01923	1.094e-48	175.0	COG4830@1|root,arCOG04305@2157|Archaea,41SNM@651137|Thaumarchaeota	651137|Thaumarchaeota	J	ribosomal protein	-	-	-	ko:K02976	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S26e
TLS1_k127_4425081_0	1459636.NTE_01921	5.547e-154	492.0	COG0061@1|root,COG0640@1|root,arCOG00394@2157|Archaea,arCOG01348@2157|Archaea,41SEC@651137|Thaumarchaeota	651137|Thaumarchaeota	HK	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	-	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
TLS1_k127_4425081_3	1459636.NTE_01920	1.754e-77	264.0	COG0504@1|root,arCOG00063@2157|Archaea,41S7G@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
TLS1_k127_4426096_0	1459636.NTE_01231	0.0	1071.0	COG1048@1|root,arCOG01697@2157|Archaea,41SE6@651137|Thaumarchaeota	651137|Thaumarchaeota	C	aconitate hydratase	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
TLS1_k127_4426096_1	1459636.NTE_02704	3.631e-37	141.0	arCOG08662@1|root,arCOG08662@2157|Archaea,41SQG@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4446690_4	1459636.NTE_01555	1.445e-71	248.0	COG0063@1|root,arCOG00018@2157|Archaea,41SHM@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX	nnrE	-	5.1.99.6	ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	YjeF_N
TLS1_k127_4446690_3	1459636.NTE_01556	6.074e-75	257.0	arCOG00517@1|root,arCOG00517@2157|Archaea,41SHJ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS1_k127_4446690_1	1459636.NTE_01557	5.433e-115	381.0	COG2038@1|root,arCOG04272@2157|Archaea,41SD3@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Belongs to the UPF0284 family	-	-	-	-	-	-	-	-	-	-	-	-	DBI_PRT
TLS1_k127_4446690_0	1459636.NTE_02790	1.268e-145	468.0	COG0130@1|root,arCOG00987@2157|Archaea,41S8E@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	-	-	ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03032	-	-	-	DKCLD,PUA,TruB_C_2,TruB_N
TLS1_k127_4446690_6	1459636.NTE_01485	4.486e-09	61.0	COG3432@1|root,arCOG01055@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
TLS1_k127_4446690_2	1229909.NSED_01900	5.43e-111	362.0	COG0605@1|root,arCOG04147@2157|Archaea,41S6C@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	-	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
TLS1_k127_4465795_1	1459636.NTE_01730	2.09e-27	117.0	arCOG04615@1|root,arCOG04615@2157|Archaea	2157|Archaea	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS1_k127_4465795_0	1459636.NTE_01123	1.525e-82	299.0	COG0421@1|root,arCOG00050@2157|Archaea	2157|Archaea	H	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	GO:0003674,GO:0003824,GO:0004766,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0010487,GO:0016740,GO:0016765,GO:0034641,GO:0042401,GO:0043918,GO:0043919,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0050314,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
TLS1_k127_4479493_2	1459636.NTE_01491	2.05e-18	91.0	COG0784@1|root,arCOG02391@2157|Archaea	1459636.NTE_01491|-	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4479493_0	1459636.NTE_01027	2.939e-173	552.0	COG1078@1|root,arCOG04430@2157|Archaea,41T0P@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
TLS1_k127_4479493_1	1459636.NTE_01026	4.583e-71	247.0	COG0528@1|root,arCOG00858@2157|Archaea,41T1R@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
TLS1_k127_4488568_0	1459636.NTE_01059	0.0	1095.0	COG1201@1|root,arCOG00557@2157|Archaea,41S8P@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DEAD/H associated	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
TLS1_k127_4494383_2	1459636.NTE_03279	3.476e-238	740.0	COG1155@1|root,arCOG00868@2157|Archaea,41SZU@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
TLS1_k127_4494383_0	1459636.NTE_03278	8.857e-266	822.0	COG1156@1|root,arCOG00865@2157|Archaea,41SPY@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
TLS1_k127_4494383_3	1459636.NTE_03277	2.75e-105	345.0	COG1394@1|root,arCOG04101@2157|Archaea,41T0N@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
TLS1_k127_4494383_6	1459636.NTE_03275	3.1e-26	111.0	COG0636@1|root,arCOG02455@2157|Archaea,41T6A@651137|Thaumarchaeota	651137|Thaumarchaeota	C	ATP synthase subunit C	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
TLS1_k127_4494383_1	1459636.NTE_03274	2.282e-259	818.0	COG1269@1|root,arCOG04138@2157|Archaea,41SRH@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
TLS1_k127_4494383_4	1459636.NTE_00401	5.783e-93	312.0	COG1794@1|root,arCOG02005@2157|Archaea,41SM4@651137|Thaumarchaeota	651137|Thaumarchaeota	M	Asp/Glu/Hydantoin racemase	-	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
TLS1_k127_4494383_5	1459636.NTE_01391	4.318e-68	235.0	COG1234@1|root,arCOG00501@2157|Archaea,41SF7@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B,Lactamase_B_2
TLS1_k127_4496021_0	693661.Arcve_0993	5.209e-159	527.0	COG0383@1|root,arCOG03661@2157|Archaea,2XVNX@28890|Euryarchaeota	28890|Euryarchaeota	G	Alpha mannosidase, middle domain	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
TLS1_k127_4501987_2	1459636.NTE_02579	1.405e-145	471.0	COG0644@1|root,arCOG00570@2157|Archaea,41S82@651137|Thaumarchaeota	651137|Thaumarchaeota	C	geranylgeranyl reductase	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_oxidored,Trp_halogenase
TLS1_k127_4501987_6	1459636.NTE_02559	3.678e-63	218.0	COG0838@1|root,arCOG01557@2157|Archaea,41SMI@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM NADH-ubiquinone plastoquinone oxidoreductase chain 3	-	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
TLS1_k127_4501987_3	1459636.NTE_02558	1.257e-98	323.0	COG0377@1|root,arCOG01554@2157|Archaea,41S6D@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Belongs to the complex I 20 kDa subunit family	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
TLS1_k127_4501987_5	1459636.NTE_02557	8.414e-74	254.0	COG0852@1|root,arCOG01551@2157|Archaea,41SJS@651137|Thaumarchaeota	651137|Thaumarchaeota	C	NADH ubiquinone oxidoreductase 27 kD subunit	-	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
TLS1_k127_4501987_0	1459636.NTE_02556	1.433e-227	707.0	COG0649@1|root,arCOG01548@2157|Archaea,41S62@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Belongs to the complex I 49 kDa subunit family	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
TLS1_k127_4501987_1	1459636.NTE_02555	9.108e-192	606.0	COG1005@1|root,arCOG01546@2157|Archaea,41SAT@651137|Thaumarchaeota	651137|Thaumarchaeota	C	NADH dehydrogenase	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
TLS1_k127_4501987_4	1459636.NTE_02554	9.486e-95	314.0	COG1143@1|root,arCOG01543@2157|Archaea,41SGW@651137|Thaumarchaeota	651137|Thaumarchaeota	C	4Fe-4S binding domain	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_4
TLS1_k127_4501987_7	1459636.NTE_00881	6.14e-26	112.0	COG0589@1|root,arCOG02053@2157|Archaea,41T8M@651137|Thaumarchaeota	651137|Thaumarchaeota	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS1_k127_4503715_3	1459636.NTE_00785	9.652e-44	163.0	arCOG08684@1|root,arCOG08684@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4503715_2	1459636.NTE_02873	2.526e-105	347.0	COG1028@1|root,arCOG01259@2157|Archaea,41SXY@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS1_k127_4503715_0	1459636.NTE_02293	7.45e-247	776.0	COG1855@1|root,arCOG04116@2157|Archaea,41SX0@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Large family of predicted nucleotide-binding domains	-	-	-	ko:K06865	-	-	-	-	ko00000	-	-	-	KH_1,T2SSE
TLS1_k127_4503715_1	1459636.NTE_02048	5.973e-162	515.0	COG1085@1|root,arCOG00422@2157|Archaea,41S6T@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Galactose-1-phosphate uridyl transferase, N-terminal domain	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_transf
TLS1_k127_4503715_4	1459636.NTE_02047	2.375e-22	103.0	arCOG08683@1|root,arCOG08683@2157|Archaea,41SUM@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4511639_1	1459636.NTE_01415	4.009e-72	251.0	COG1782@1|root,arCOG00543@2157|Archaea,41T05@651137|Thaumarchaeota	651137|Thaumarchaeota	S	RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_7,Lactamase_B_6,RMMBL
TLS1_k127_4511639_2	1459636.NTE_01416	1.248e-30	123.0	COG2450@1|root,arCOG02263@2157|Archaea,41T6T@651137|Thaumarchaeota	651137|Thaumarchaeota	D	Pfam:DUF552	-	-	-	ko:K09152	-	-	-	-	ko00000	-	-	-	SepF
TLS1_k127_4511639_0	1459636.NTE_01417	2.32e-131	427.0	COG0301@1|root,arCOG00038@2157|Archaea,41T1A@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Thiamine biosynthesis protein (ThiI)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,ThiI
TLS1_k127_4511639_3	273057.SSO3174	1.879e-11	70.0	COG0517@1|root,arCOG00606@2157|Archaea,2XQQK@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS1_k127_4522885_0	72558.CBQ72551	6.361e-06	48.0	COG1845@1|root,KOG4664@2759|Eukaryota,39ASV@33154|Opisthokonta,3NUQM@4751|Fungi,3V05G@5204|Basidiomycota	4751|Fungi	C	Subunits I, II and III form the functional core of the enzyme complex	cox3	GO:0003674,GO:0003824,GO:0004129,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005751,GO:0006091,GO:0006119,GO:0006123,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009055,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0016491,GO:0016675,GO:0016676,GO:0017144,GO:0019637,GO:0019646,GO:0019693,GO:0019866,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0031090,GO:0031224,GO:0031966,GO:0031967,GO:0031975,GO:0032991,GO:0034220,GO:0034641,GO:0042773,GO:0042775,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045277,GO:0045333,GO:0046034,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0070069,GO:0070469,GO:0071704,GO:0072521,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902600	-	ko:K02262	ko00190,ko01100,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04260,map04714,map04932,map05010,map05012,map05016	M00154	-	-	ko00000,ko00001,ko00002,ko03029	3.D.4.11,3.D.4.7,3.D.4.8	-	-	COX3
TLS1_k127_4560654_0	1459636.NTE_02907	2.666e-241	746.0	COG0010@1|root,arCOG01700@2157|Archaea,41T03@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the arginase family	-	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
TLS1_k127_4580230_3	1459636.NTE_01738	1.444e-15	77.0	COG2260@1|root,arCOG00906@2157|Archaea,41SUI@651137|Thaumarchaeota	651137|Thaumarchaeota	J	more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA	nop10	-	-	ko:K11130	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko03009,ko03032	-	-	-	Nop10p
TLS1_k127_4580230_0	1459636.NTE_01737	4.363e-99	330.0	COG1093@1|root,arCOG04107@2157|Archaea,41SHY@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Translation initiation factor 2, alpha subunit	-	-	-	ko:K03237	ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168	-	-	-	ko00000,ko00001,ko03012	-	-	-	EIF_2_alpha,S1
TLS1_k127_4580230_1	1459636.NTE_01736	8.237e-71	243.0	COG2109@1|root,arCOG04678@2157|Archaea,41SFP@651137|Thaumarchaeota	651137|Thaumarchaeota	H	ATP corrinoid adenosyltransferase	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
TLS1_k127_4580230_2	1459636.NTE_01720	1.841e-30	129.0	COG4063@1|root,arCOG03220@2157|Archaea,41T46@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Tetrahydromethanopterin S-methyltransferase, subunit A	-	-	2.1.1.86	ko:K00577	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrA
TLS1_k127_4580230_4	1123508.JH636439_gene1142	1.026e-08	57.0	COG0454@1|root,COG0456@2|Bacteria,2J0C3@203682|Planctomycetes	203682|Planctomycetes	K	Acetyltransferase (GNAT) domain	-	-	2.3.1.4	ko:K00621	ko00520,map00520	-	R02058	RC00004,RC00166	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1
TLS1_k127_4607280_3	224719.Abm4_1559	2.514e-07	55.0	COG0167@1|root,arCOG00603@2157|Archaea,2XTMB@28890|Euryarchaeota,23NRT@183925|Methanobacteria	183925|Methanobacteria	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
TLS1_k127_4607280_0	237368.SCABRO_00226	2.22e-82	282.0	COG1082@1|root,COG1082@2|Bacteria,2IZG2@203682|Planctomycetes	203682|Planctomycetes	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS1_k127_4607280_2	1459636.NTE_01410	2.056e-52	191.0	COG1628@1|root,arCOG00928@2157|Archaea,41SMQ@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Protein of unknown function DUF99	-	-	-	ko:K09120	-	-	-	-	ko00000	-	-	-	DUF99
TLS1_k127_4607280_1	1459636.NTE_01676	8.805e-62	225.0	arCOG08669@1|root,arCOG08669@2157|Archaea,41SEB@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4618626_2	1459636.NTE_02795	1.603e-36	139.0	COG0200@1|root,arCOG00779@2157|Archaea,41SQY@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Binds to the 23S rRNA	rpl15	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
TLS1_k127_4618626_1	1459636.NTE_02796	4.435e-48	177.0	COG1841@1|root,arCOG04086@2157|Archaea,41SMX@651137|Thaumarchaeota	651137|Thaumarchaeota	J	ribosomal protein	-	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
TLS1_k127_4618626_0	1459636.NTE_02797	4.165e-100	329.0	COG0098@1|root,arCOG04087@2157|Archaea,41SFS@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the universal ribosomal protein uS5 family	-	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
TLS1_k127_4618626_3	604354.TSIB_0308	6.857e-07	53.0	COG0256@1|root,arCOG04088@2157|Archaea,2XTWT@28890|Euryarchaeota,243VI@183968|Thermococci	183968|Thermococci	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rpl18	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18_c,Ribosomal_L5e
TLS1_k127_4621350_2	1459636.NTE_02751	1.004e-37	145.0	COG2012@1|root,arCOG04258@2157|Archaea,41SU8@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoH	-	2.7.7.6	ko:K03053	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb5_C
TLS1_k127_4621350_0	1459636.NTE_02750	0.0	2032.0	COG0085@1|root,arCOG01762@2157|Archaea,41SF5@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	-	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
TLS1_k127_4621350_1	1459636.NTE_02749	5.861e-247	765.0	COG0086@1|root,arCOG04256@2157|Archaea,arCOG04257@2157|Archaea,41SB2@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	-	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
TLS1_k127_4635567_0	1459636.NTE_01790	1.834e-118	391.0	COG0156@1|root,arCOG00113@2157|Archaea,41SAP@651137|Thaumarchaeota	651137|Thaumarchaeota	E	8-amino-7-oxononanoate synthase	-	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS1_k127_4656295_1	1459636.NTE_03144	7.631e-36	139.0	COG0604@1|root,arCOG01458@2157|Archaea	2157|Archaea	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
TLS1_k127_4656295_2	1459636.NTE_00830	9.243e-25	106.0	COG3324@1|root,arCOG04946@2157|Archaea	2157|Archaea	S	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	-
TLS1_k127_4656295_3	1006006.Mcup_1406	8.1e-20	96.0	COG1522@1|root,arCOG01580@2157|Archaea,2XQS8@28889|Crenarchaeota	28889|Crenarchaeota	K	ASNC family	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
TLS1_k127_4659361_1	1459636.NTE_01534	2.967e-11	66.0	COG0389@1|root,COG1801@1|root,arCOG04291@2157|Archaea,arCOG04582@2157|Archaea,41SDV@651137|Thaumarchaeota	2157|Archaea	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis	dbh	-	2.7.7.7	ko:K04479	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
TLS1_k127_4659361_0	588596.U9V138	2.207e-23	116.0	2CMAY@1|root,2QPU8@2759|Eukaryota,38EXZ@33154|Opisthokonta,3NUZ4@4751|Fungi	4751|Fungi	G	Glycoside hydrolase family 5	-	GO:0000322,GO:0000323,GO:0000324,GO:0000329,GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005774,GO:0005829,GO:0006629,GO:0006706,GO:0008150,GO:0008152,GO:0008202,GO:0008422,GO:0009056,GO:0015926,GO:0016020,GO:0016042,GO:0016134,GO:0016136,GO:0016137,GO:0016139,GO:0016787,GO:0016798,GO:0031090,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044422,GO:0044424,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0050295,GO:0071704,GO:0098588,GO:0098805,GO:0098852,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901575,GO:1901657,GO:1901658,GO:1901804,GO:1901805,GO:1904461,GO:1904462	-	-	-	-	-	-	-	-	-	-	Cellulase
TLS1_k127_4659412_1	264732.Moth_0927	1e-10	64.0	COG3118@1|root,COG3118@2|Bacteria,1VA3Y@1239|Firmicutes,24MM5@186801|Clostridia,42GS3@68295|Thermoanaerobacterales	186801|Clostridia	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
TLS1_k127_4659412_0	1459636.NTE_02862	1.288e-204	647.0	arCOG00144@1|root,arCOG00144@2157|Archaea	2157|Archaea	S	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS1_k127_4659412_2	1173023.KE650771_gene1224	0.0006972	44.0	COG1785@1|root,COG1785@2|Bacteria,1G4BJ@1117|Cyanobacteria	1117|Cyanobacteria	P	Alkaline phosphatase	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase
TLS1_k127_4666237_0	1459636.NTE_00800	0.0	1292.0	COG0480@1|root,arCOG01559@2157|Archaea,41S9B@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
TLS1_k127_4666237_1	1459636.NTE_01978	4.115e-148	479.0	COG3769@1|root,arCOG04158@2157|Archaea	2157|Archaea	S	Mannosyl-3-phosphoglycerate synthase	mngA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.4.1.217	ko:K05947	ko00051,map00051	-	R05768	RC00005,RC00397,RC02748	ko00000,ko00001,ko01000,ko01003	-	-	-	Osmo_MPGsynth
TLS1_k127_4672712_4	1459636.NTE_02408	5.323e-34	134.0	arCOG08080@1|root,arCOG08080@2157|Archaea,41SUA@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4672712_3	1459636.NTE_01318	6.601e-38	143.0	arCOG08720@1|root,arCOG08720@2157|Archaea,41STI@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Domain of unknown function (DUF2024)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2024
TLS1_k127_4672712_0	1459636.NTE_02684	5.976e-148	477.0	COG1679@1|root,arCOG04278@2157|Archaea,41SBC@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
TLS1_k127_4672712_5	1459636.NTE_02685	3.399e-31	127.0	COG1786@1|root,arCOG04279@2157|Archaea,41SPA@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Protein of unknown function DUF126	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
TLS1_k127_4672712_6	1459636.NTE_02686	2.592e-23	100.0	arCOG08817@1|root,arCOG08817@2157|Archaea,41SV5@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4672712_2	1459636.NTE_02687	1.897e-110	364.0	COG0037@1|root,arCOG00042@2157|Archaea,41S84@651137|Thaumarchaeota	651137|Thaumarchaeota	D	PP-loop family	-	-	-	-	-	-	-	-	-	-	-	-	ATP_bind_3
TLS1_k127_4672712_1	1459636.NTE_02703	3.778e-142	458.0	COG1736@1|root,arCOG04112@2157|Archaea,41SE0@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Diphthamide biosynthesis	-	-	2.5.1.108	ko:K07561	-	-	R10455	RC00021,RC03180	ko00000,ko01000,ko03012	-	-	-	Diphthamide_syn
TLS1_k127_4678957_1	28072.Nos7524_1911	3.02e-06	56.0	COG0438@1|root,COG0438@2|Bacteria,1G2QJ@1117|Cyanobacteria,1HN1D@1161|Nostocales	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
TLS1_k127_4693058_1	1459636.NTE_03124	4.925e-35	139.0	COG0524@1|root,arCOG00014@2157|Archaea	2157|Archaea	G	Belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB,Regulator_TrmB,TrmB
TLS1_k127_4693058_0	1459636.NTE_00448	2.425e-62	219.0	COG1303@1|root,arCOG01857@2157|Archaea,41SIR@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs	-	-	2.1.1.206	ko:K07254	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Trm56
TLS1_k127_4735576_1	1459636.NTE_01784	8.562e-115	378.0	COG0147@1|root,arCOG02014@2157|Archaea,41S8W@651137|Thaumarchaeota	651137|Thaumarchaeota	E	component I	-	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
TLS1_k127_4735576_4	436308.Nmar_1629	1.592e-10	63.0	arCOG08792@1|root,arCOG08792@2157|Archaea,41SUG@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4735576_3	1459636.NTE_01105	8.905e-16	78.0	arCOG04508@1|root,arCOG04508@2157|Archaea,41SVW@651137|Thaumarchaeota	651137|Thaumarchaeota	P	YHS domain	-	-	-	-	-	-	-	-	-	-	-	-	YHS
TLS1_k127_4735576_0	1459636.NTE_02181	6.584e-116	382.0	COG1063@1|root,arCOG01459@2157|Archaea,41S98@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Glucose dehydrogenase C-terminus	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS1_k127_4735576_2	1459636.NTE_02180	8.683e-33	128.0	COG1830@1|root,arCOG04044@2157|Archaea,41S64@651137|Thaumarchaeota	651137|Thaumarchaeota	E	DeoC/LacD family aldolase	-	-	2.3.1.245	ko:K08321	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000	-	-	-	DeoC
TLS1_k127_4737561_1	1459636.NTE_01508	6.756e-24	109.0	arCOG08764@1|root,arCOG08764@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4737561_0	1459636.NTE_00230	6.391e-94	316.0	COG0168@1|root,COG0517@1|root,arCOG00606@2157|Archaea,arCOG04145@2157|Archaea,41SZ8@651137|Thaumarchaeota	651137|Thaumarchaeota	P	CBS domain	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	CBS,TrkH
TLS1_k127_4745833_0	1459636.NTE_02626	5.347e-91	309.0	COG2141@1|root,arCOG02410@2157|Archaea	2157|Archaea	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS1_k127_4745833_1	1459636.NTE_01054	2.035e-37	143.0	arCOG08023@1|root,arCOG08023@2157|Archaea,41SKK@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Zinc finger domain	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
TLS1_k127_4745833_3	1120973.AQXL01000117_gene343	5.001e-13	74.0	2F6QX@1|root,33Z76@2|Bacteria,1VY7H@1239|Firmicutes,4HWZV@91061|Bacilli,27A4C@186823|Alicyclobacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4752751_0	1459636.NTE_00935	7.338e-114	376.0	COG0053@1|root,arCOG01474@2157|Archaea	2157|Archaea	P	cation diffusion facilitator family transporter	cef	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
TLS1_k127_4791298_0	1459636.NTE_01674	2.094e-120	395.0	COG0444@1|root,arCOG00181@2157|Archaea,41S9V@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS1_k127_4791298_1	1459636.NTE_02652	2.752e-60	211.0	COG0520@1|root,arCOG00065@2157|Archaea,41SCV@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
TLS1_k127_4795625_1	1459636.NTE_03112	1.058e-68	234.0	COG1522@1|root,arCOG01580@2157|Archaea,41SKI@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Lrp/AsnC ligand binding domain	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24
TLS1_k127_4795625_0	1459636.NTE_03111	2.61e-144	462.0	COG0109@1|root,arCOG00479@2157|Archaea,41SFH@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	-	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
TLS1_k127_4795625_3	1229909.NSED_08860	5.295e-55	202.0	COG1756@1|root,arCOG04122@2157|Archaea,41T2T@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA	nep1	-	2.1.1.260	ko:K14568	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009	-	-	-	EMG1
TLS1_k127_4795625_5	1459636.NTE_03109	1.212e-24	106.0	COG2023@1|root,arCOG04345@2157|Archaea,41STS@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp4	-	3.1.26.5	ko:K03540	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Rpr2
TLS1_k127_4795625_2	1459636.NTE_03108	1.299e-66	229.0	COG2238@1|root,arCOG01344@2157|Archaea,41SK1@651137|Thaumarchaeota	651137|Thaumarchaeota	J	May be involved in maturation of the 30S ribosomal subunit	rps19e	-	-	ko:K02966	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19e
TLS1_k127_4795625_4	1459636.NTE_03107	7.249e-30	121.0	COG2118@1|root,arCOG04179@2157|Archaea,41SR0@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Belongs to the PDCD5 family	-	-	-	ko:K06875	-	-	-	-	ko00000	-	-	-	dsDNA_bind
TLS1_k127_4795625_6	1459636.NTE_03106	2.602e-06	49.0	COG0604@1|root,arCOG01458@2157|Archaea,41SZ9@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
TLS1_k127_4818133_0	1459636.NTE_02722	3.758e-230	730.0	COG2511@1|root,arCOG01719@2157|Archaea,41S8Q@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	-	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GAD,GatB_N,GatB_Yqey
TLS1_k127_4823466_0	1459636.NTE_02802	2.624e-163	524.0	COG1944@1|root,arCOG02882@2157|Archaea	2157|Archaea	H	methanogenesis marker protein 1	-	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	YcaO
TLS1_k127_4823466_1	1459636.NTE_02803	9.826e-73	253.0	COG3482@1|root,arCOG05002@2157|Archaea	2157|Archaea	S	PFAM TfuA domain protein, core	-	-	-	-	-	-	-	-	-	-	-	-	TfuA
TLS1_k127_4828247_0	1459636.NTE_02683	7.002e-82	276.0	COG0177@1|root,arCOG00459@2157|Archaea,41SFM@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
TLS1_k127_4828247_1	1459636.NTE_02682	1.092e-47	180.0	arCOG08818@1|root,arCOG08818@2157|Archaea,41SVV@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4828247_2	1367847.JCM7686_2904	0.0002688	44.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	HNH
TLS1_k127_4829652_1	436308.Nmar_0648	1.133e-25	111.0	COG1899@1|root,arCOG04142@2157|Archaea,41SDB@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Deoxyhypusine synthase	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
TLS1_k127_4829652_2	1122138.AQUZ01000066_gene4373	4.527e-06	53.0	COG2823@1|root,COG2823@2|Bacteria,2IS5M@201174|Actinobacteria	201174|Actinobacteria	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
TLS1_k127_4829652_0	1459636.NTE_03043	6.214e-162	516.0	COG1899@1|root,arCOG04142@2157|Archaea,41SWS@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Deoxyhypusine synthase	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
TLS1_k127_484100_3	1094508.Tsac_1654	4.977e-60	211.0	COG0113@1|root,COG0113@2|Bacteria,1TP09@1239|Firmicutes,2496V@186801|Clostridia,42EWI@68295|Thermoanaerobacterales	186801|Clostridia	H	Delta-aminolevulinic acid dehydratase	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS15750	ALAD
TLS1_k127_484100_0	1459636.NTE_01013	4.737e-159	511.0	COG0001@1|root,arCOG00918@2157|Archaea,41SDE@651137|Thaumarchaeota	651137|Thaumarchaeota	H	PFAM aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS1_k127_484100_1	1459636.NTE_01012	1.357e-95	322.0	COG0181@1|root,arCOG04299@2157|Archaea,41S6Z@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
TLS1_k127_484100_2	1459636.NTE_01011	3.335e-65	228.0	COG0007@1|root,arCOG00644@2157|Archaea,41S9J@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Belongs to the precorrin methyltransferase family	-	-	2.1.1.107	ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03194	RC00003,RC00871	ko00000,ko00001,ko00002,ko01000	-	-	-	TP_methylase
TLS1_k127_487885_1	1459636.NTE_01584	8.126e-152	483.0	COG0119@1|root,arCOG02092@2157|Archaea,41S7Y@651137|Thaumarchaeota	651137|Thaumarchaeota	E	HMGL-like	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
TLS1_k127_487885_4	1459636.NTE_01583	2.017e-24	102.0	arCOG01588@1|root,arCOG01588@2157|Archaea,41STK@651137|Thaumarchaeota	651137|Thaumarchaeota	E	lysine biosynthesis protein LysW	-	-	-	ko:K05826	-	M00031,M00763	-	-	ko00000,ko00001,ko00002	-	-	-	-
TLS1_k127_487885_2	1459636.NTE_01582	6.996e-122	397.0	COG0189@1|root,arCOG01589@2157|Archaea,41SE8@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Lysine biosynthesis	-	-	6.3.2.43	ko:K05827	ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230	M00031	R09775	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	RimK
TLS1_k127_487885_0	1459636.NTE_01581	4.213e-165	526.0	COG0624@1|root,arCOG01107@2157|Archaea,41SAX@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the release of L-lysine from LysW -gamma-L- lysine and the release of L-ornithine from LysW -L-ornithine	lysK	-	-	ko:K05831	ko00220,ko00300,ko01100,ko01210,ko01230,map00220,map00300,map01100,map01210,map01230	M00031,M00763	R09779,R10933	RC00064,RC00090	ko00000,ko00001,ko00002	-	-	-	M20_dimer,Peptidase_M20
TLS1_k127_487885_3	1459636.NTE_01580	3.365e-117	386.0	COG1798@1|root,COG1849@1|root,arCOG01224@2157|Archaea,arCOG04161@2157|Archaea,41SC2@651137|Thaumarchaeota	651137|Thaumarchaeota	H	diphthine synthase	-	-	2.1.1.98	ko:K20215	-	-	R04481,R08468,R08469,R10306	RC00003,RC00190,RC01155,RC02136,RC02308	ko00000,ko01000	-	-	-	DUF357,TP_methylase
TLS1_k127_4907682_0	1459636.NTE_03307	2.822e-169	546.0	COG0343@1|root,arCOG00989@2157|Archaea,41SF4@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs	tgtA	-	2.4.2.48	ko:K18779	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TGT
TLS1_k127_4907682_1	1459636.NTE_03306	2.021e-61	214.0	COG1958@1|root,arCOG00999@2157|Archaea	2157|Archaea	K	PFAM Like-Sm ribonucleoprotein, core	-	-	-	-	-	-	-	-	-	-	-	-	LSM,Lsm_C,SM-ATX
TLS1_k127_4908887_0	436308.Nmar_0044	1.044e-81	280.0	COG0300@1|root,arCOG01263@2157|Archaea,41SXQ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
TLS1_k127_4946473_0	1459636.NTE_01164	8.28e-70	256.0	arCOG00144@1|root,arCOG11894@1|root,arCOG00144@2157|Archaea,arCOG11894@2157|Archaea	2157|Archaea	S	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS1_k127_4946988_0	1459636.NTE_01784	4.982e-38	148.0	COG0147@1|root,arCOG02014@2157|Archaea,41S8W@651137|Thaumarchaeota	651137|Thaumarchaeota	E	component I	-	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
TLS1_k127_4946988_1	1459636.NTE_01981	4.563e-08	59.0	COG2379@1|root,arCOG04170@2157|Archaea,41SJF@651137|Thaumarchaeota	651137|Thaumarchaeota	G	MOFRL family	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
TLS1_k127_4976383_1	1459636.NTE_00731	1.087e-64	224.0	COG0137@1|root,arCOG00112@2157|Archaea,41S6K@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
TLS1_k127_4976383_0	1459636.NTE_00729	1.881e-77	269.0	COG5012@1|root,arCOG03932@1|root,arCOG03402@2157|Archaea,arCOG03932@2157|Archaea,41SKB@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Cobalamin B12-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4985251_0	1459636.NTE_01644	5.26e-195	640.0	COG1196@1|root,arCOG00371@2157|Archaea,41SDS@651137|Thaumarchaeota	651137|Thaumarchaeota	D	SMC proteins Flexible Hinge Domain	-	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
TLS1_k127_4987084_4	1459636.NTE_00737	1.138e-36	141.0	COG1522@1|root,arCOG01580@2157|Archaea,41SNE@651137|Thaumarchaeota	651137|Thaumarchaeota	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_AsnC-type
TLS1_k127_4987084_1	1459636.NTE_00736	3.859e-175	556.0	COG4992@1|root,arCOG00914@2157|Archaea,41SC8@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	lysJ	-	-	ko:K05830	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00031,M00763	R09778,R10932	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS1_k127_4987084_2	1459636.NTE_00735	7.352e-111	364.0	COG0548@1|root,arCOG00862@2157|Archaea,41SFB@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis)	lysZ	-	-	ko:K05828	ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230	M00031,M00763	R09776,R10930	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
TLS1_k127_4987084_0	1459636.NTE_00734	8.612e-190	596.0	COG0002@1|root,arCOG00495@2157|Archaea,41S8R@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily	lysY	-	-	ko:K05829	ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230	M00031,M00763	R09777,R10931	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
TLS1_k127_4987084_3	1459636.NTE_00731	1.148e-74	256.0	COG0137@1|root,arCOG00112@2157|Archaea,41S6K@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
TLS1_k127_4988198_0	1459636.NTE_02310	6.474e-112	370.0	COG1052@1|root,arCOG01755@2157|Archaea,41T1D@651137|Thaumarchaeota	651137|Thaumarchaeota	C	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS1_k127_4988198_1	1459636.NTE_02804	2.185e-61	216.0	COG2096@1|root,arCOG00489@2157|Archaea,41T2I@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Cobalamin adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
TLS1_k127_4992506_0	1459636.NTE_02328	3.581e-168	538.0	COG0034@1|root,arCOG00093@2157|Archaea,41S7N@651137|Thaumarchaeota	2157|Archaea	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
TLS1_k127_4992506_2	1459636.NTE_02329	6.226e-16	83.0	arCOG08657@1|root,arCOG08657@2157|Archaea,41SRB@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_4992506_3	1459636.NTE_02321	6.253e-11	67.0	COG3432@1|root,arCOG01055@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
TLS1_k127_5017246_2	1122599.AUGR01000025_gene1488	6.469e-15	79.0	COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,1RPH6@1236|Gammaproteobacteria,1XKFV@135619|Oceanospirillales	135619|Oceanospirillales	P	Sodium/hydrogen exchanger family	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger
TLS1_k127_5017246_1	1459636.NTE_00881	8.748e-26	112.0	COG0589@1|root,arCOG02053@2157|Archaea,41T8M@651137|Thaumarchaeota	651137|Thaumarchaeota	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS1_k127_5017246_0	1459636.NTE_01495	1.651e-178	569.0	COG1653@1|root,arCOG00151@2157|Archaea	2157|Archaea	G	COG1653 ABC-type sugar transport system, periplasmic component	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
TLS1_k127_5051004_3	1202768.JROF01000035_gene2268	4.831e-26	112.0	COG1184@1|root,arCOG01127@2157|Archaea,2XUMH@28890|Euryarchaeota,23SF4@183963|Halobacteria	183963|Halobacteria	J	Belongs to the eIF-2B alpha beta delta subunits family	tif2Ba	-	-	-	-	-	-	-	-	-	-	-	IF-2B,NUDIX
TLS1_k127_5051004_1	1459636.NTE_01385	1.775e-63	227.0	COG1650@1|root,arCOG01616@2157|Archaea,41SM3@651137|Thaumarchaeota	651137|Thaumarchaeota	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
TLS1_k127_5051004_0	1459636.NTE_01384	2.111e-68	238.0	COG0250@1|root,arCOG01920@2157|Archaea,41SM6@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Transcription elongation factor Spt5	spt5	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,Spt5-NGN
TLS1_k127_5051004_2	1459636.NTE_01197	2.301e-32	126.0	COG0080@1|root,arCOG04372@2157|Archaea,41SJW@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rpl11	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
TLS1_k127_5079464_0	1459636.NTE_00538	1.366e-199	626.0	COG1053@1|root,arCOG00571@2157|Archaea,41SAM@651137|Thaumarchaeota	2157|Archaea	C	fumarate reductase flavoprotein	sdhA2	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TLS1_k127_5079464_2	1459636.NTE_00538	1.013e-83	282.0	COG1053@1|root,arCOG00571@2157|Archaea,41SAM@651137|Thaumarchaeota	2157|Archaea	C	fumarate reductase flavoprotein	sdhA2	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TLS1_k127_5079464_1	1459636.NTE_01425	2.684e-113	370.0	COG0028@1|root,arCOG01999@2157|Archaea	2157|Archaea	C	Belongs to the TPP enzyme family	-	-	1.2.3.3,1.2.5.1	ko:K00156,ko:K00158	ko00620,ko01100,map00620,map01100	-	R00207,R03145	RC00860,RC02745	ko00000,ko00001,ko01000	-	-	-	Rubredoxin,TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS1_k127_5122071_0	1459636.NTE_02626	1.052e-120	395.0	COG2141@1|root,arCOG02410@2157|Archaea	2157|Archaea	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS1_k127_5122071_1	1459636.NTE_02627	1.254e-35	142.0	arCOG00516@1|root,arCOG00516@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS1_k127_5122071_2	373903.Hore_15890	4.558e-34	145.0	COG1597@1|root,COG1597@2|Bacteria,1TQAU@1239|Firmicutes,25CN4@186801|Clostridia,3WB2H@53433|Halanaerobiales	186801|Clostridia	I	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
TLS1_k127_5129732_1	1121481.AUAS01000015_gene2252	3.253e-55	206.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,4NESR@976|Bacteroidetes,47NMI@768503|Cytophagia	976|Bacteroidetes	L	DNA polymerase Ligase (LigD)	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
TLS1_k127_5129732_0	748247.AZKH_2968	7.14e-83	289.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,2VIAB@28216|Betaproteobacteria	28216|Betaproteobacteria	L	DNA ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	-
TLS1_k127_5130369_1	1459636.NTE_01420	3.529e-12	68.0	COG0180@1|root,arCOG01887@2157|Archaea,41SDK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
TLS1_k127_5130369_0	1459636.NTE_01419	1.772e-149	488.0	COG0016@1|root,arCOG00410@2157|Archaea,41S9U@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Phenylalanyl-tRNA synthetase alpha subunit	-	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
TLS1_k127_513405_3	1459636.NTE_01738	1.444e-15	77.0	COG2260@1|root,arCOG00906@2157|Archaea,41SUI@651137|Thaumarchaeota	651137|Thaumarchaeota	J	more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA	nop10	-	-	ko:K11130	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko03009,ko03032	-	-	-	Nop10p
TLS1_k127_513405_4	443255.SCLAV_1862	8.32e-10	68.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	quiC	-	4.2.1.118	ko:K09483	ko00400,ko01110,ko01130,map00400,map01110,map01130	-	R01627	RC00568	ko00000,ko00001,ko01000	-	-	-	Beta_helix,CHU_C,NosD
TLS1_k127_513405_0	1459636.NTE_01739	1.301e-144	466.0	COG0644@1|root,arCOG00570@2157|Archaea,41SCG@651137|Thaumarchaeota	2157|Archaea	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,NAD_binding_8,Pyr_redox_2
TLS1_k127_513405_1	1459636.NTE_02165	7.74e-100	333.0	arCOG04936@1|root,arCOG04936@2157|Archaea	2157|Archaea	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS1_k127_5167251_0	1459636.NTE_02895	4.532e-298	932.0	COG0589@1|root,COG0591@1|root,arCOG01316@2157|Archaea,arCOG02053@2157|Archaea,41SZY@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K20989	-	-	-	-	ko00000,ko02000	2.A.21.6	-	-	SSF,Usp
TLS1_k127_5167251_2	1459636.NTE_02896	4.091e-84	282.0	COG1522@1|root,arCOG01580@2157|Archaea,41T24@651137|Thaumarchaeota	651137|Thaumarchaeota	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5167251_1	1459636.NTE_02897	3.564e-114	375.0	COG1475@1|root,arCOG11113@2157|Archaea,41SYF@651137|Thaumarchaeota	651137|Thaumarchaeota	K	ParB-like nuclease domain	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
TLS1_k127_5167251_3	1459636.NTE_01632	1.168e-74	257.0	COG0518@1|root,arCOG00090@2157|Archaea,41T3Z@651137|Thaumarchaeota	651137|Thaumarchaeota	F	glutamine amidotransferase	-	-	-	-	-	-	-	-	-	-	-	-	GATase
TLS1_k127_5167251_4	1459636.NTE_03041	6.538e-18	83.0	COG1899@1|root,arCOG04142@2157|Archaea,41SDB@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Deoxyhypusine synthase	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
TLS1_k127_5184822_1	1459636.NTE_02871	2.828e-49	177.0	COG0347@1|root,arCOG02305@2157|Archaea	2157|Archaea	K	Belongs to the P(II) protein family	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	DUF2226,P-II
TLS1_k127_5184822_2	1459636.NTE_02292	5.083e-45	165.0	COG0347@1|root,arCOG02305@2157|Archaea,41T9X@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Belongs to the P(II) protein family	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
TLS1_k127_5184822_0	1459636.NTE_03162	1.613e-207	651.0	COG0004@1|root,arCOG04397@2157|Archaea,41SZ0@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
TLS1_k127_528572_3	1459636.NTE_01817	8.255e-17	80.0	arCOG11395@1|root,arCOG11395@2157|Archaea,41TBH@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_528572_2	1459636.NTE_01816	5.727e-20	93.0	COG1545@1|root,arCOG01289@2157|Archaea,41SWD@651137|Thaumarchaeota	651137|Thaumarchaeota	S	nucleic-acid-binding protein containing a Zn-ribbon	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	-
TLS1_k127_528572_0	1459636.NTE_01815	5.18e-126	413.0	COG0183@1|root,arCOG01278@2157|Archaea,41SB7@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Thiolase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS1_k127_528572_1	1459636.NTE_01814	1.457e-46	173.0	COG2141@1|root,arCOG02410@2157|Archaea,41SC0@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS1_k127_532011_1	1459636.NTE_01284	5.294e-89	296.0	COG0495@1|root,arCOG00809@2157|Archaea,41SES@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
TLS1_k127_532011_0	1459636.NTE_01283	0.0	1231.0	COG0013@1|root,arCOG01255@2157|Archaea,41SBJ@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
TLS1_k127_5324689_2	1459636.NTE_02945	1.716e-47	177.0	COG0611@1|root,arCOG00638@2157|Archaea,41SIN@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
TLS1_k127_5324689_1	1459636.NTE_02936	1.123e-72	247.0	COG0100@1|root,arCOG04240@2157|Archaea,41SII@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Located on the platform of the 30S subunit	rps11	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
TLS1_k127_5324689_0	1459636.NTE_01977	0.0	1072.0	COG1257@1|root,COG3408@1|root,arCOG03287@2157|Archaea,arCOG05512@2157|Archaea	2157|Archaea	I	hydroxymethylglutaryl-CoA reductase (NADPH) activity	-	-	1.1.1.34	ko:K00021	ko00900,ko01100,ko01110,ko01130,ko04152,ko04976,map00900,map01100,map01110,map01130,map04152,map04976	M00095	R02082	RC00004,RC00644	ko00000,ko00001,ko00002,ko01000	-	-	-	GDE_C,GDE_N
TLS1_k127_5338709_3	1459636.NTE_02594	3.341e-106	349.0	COG0052@1|root,arCOG04245@2157|Archaea,41SG7@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the universal ribosomal protein uS2 family	rps2	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
TLS1_k127_5338709_4	1459636.NTE_02596	1.882e-102	340.0	COG1355@1|root,arCOG01728@2157|Archaea,41S9D@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
TLS1_k127_5338709_6	1459636.NTE_02597	2.994e-51	195.0	COG1577@1|root,arCOG01028@2157|Archaea,41SKC@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids	mvk	-	2.7.1.36	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	M00095	R02245	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
TLS1_k127_5338709_5	1459636.NTE_02263	1.026e-69	244.0	COG1608@1|root,arCOG00860@2157|Archaea,41SI4@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Amino acid kinase family	-	-	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
TLS1_k127_5338709_1	1459636.NTE_02264	2.808e-150	482.0	COG1304@1|root,arCOG00613@2157|Archaea	2157|Archaea	C	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
TLS1_k127_5338709_2	1459636.NTE_02265	8.287e-114	376.0	COG0142@1|root,arCOG01726@2157|Archaea,41SEV@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
TLS1_k127_5338709_0	1459636.NTE_02266	2.495e-199	631.0	COG0008@1|root,arCOG04302@2157|Archaea,41S5V@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
TLS1_k127_5344855_2	436308.Nmar_1583	3.778e-08	56.0	COG1270@1|root,arCOG04274@2157|Archaea,41S6I@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group	cobD	-	6.3.1.10	ko:K02227	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CobD_Cbib
TLS1_k127_5344855_1	1459636.NTE_03115	8.607e-93	312.0	COG1492@1|root,arCOG00105@2157|Archaea,41SG6@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation	cobQ	-	6.3.5.10	ko:K02232	ko00860,ko01100,map00860,map01100	M00122	R05225	RC00010,RC01302	ko00000,ko00001,ko00002,ko01000	-	-	-	CbiA
TLS1_k127_5344855_0	1459636.NTE_03114	1.042e-104	351.0	COG0079@1|root,arCOG04273@2157|Archaea,41SGU@651137|Thaumarchaeota	651137|Thaumarchaeota	E	PFAM Aminotransferase class I and II	-	-	4.1.1.81	ko:K04720	ko00860,map00860	-	R06530	RC00517	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
TLS1_k127_5400301_4	1459636.NTE_00196	1.367e-13	80.0	COG0467@1|root,arCOG01171@2157|Archaea	2157|Archaea	T	Circadian clock protein KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
TLS1_k127_5400301_2	1459636.NTE_02277	9.201e-56	198.0	COG0494@1|root,arCOG01078@2157|Archaea	2157|Archaea	L	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	apa	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	NUDIX
TLS1_k127_5400301_0	1459636.NTE_02276	4.114e-313	962.0	COG1032@1|root,arCOG01357@2157|Archaea,41S86@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS1_k127_5400301_3	1459636.NTE_02275	2.136e-45	166.0	arCOG06055@1|root,arCOG06055@2157|Archaea,41SQ3@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5400301_1	1459636.NTE_02274	7.455e-101	329.0	COG1018@1|root,arCOG02200@2157|Archaea,41S72@651137|Thaumarchaeota	651137|Thaumarchaeota	C	oxidoreductase FAD NAD(P)-binding	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	FAD_binding_6,NAD_binding_1
TLS1_k127_5444383_2	1459636.NTE_00454	1.651e-27	112.0	COG1308@1|root,arCOG04061@2157|Archaea,41SNN@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Contacts the emerging nascent chain on the ribosome	nac	-	-	ko:K03626	-	-	-	-	ko00000	-	-	-	NAC
TLS1_k127_5444383_0	1459636.NTE_02817	2.31e-186	594.0	COG0064@1|root,arCOG01718@2157|Archaea,41S9S@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
TLS1_k127_5444383_1	1459636.NTE_02818	6.491e-129	417.0	COG0154@1|root,arCOG01717@2157|Archaea,41SCW@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TLS1_k127_5463724_1	1459636.NTE_03297	4.393e-169	541.0	COG0513@1|root,arCOG00558@2157|Archaea,41SM1@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DEAD DEAH box helicase	-	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,Helicase_C
TLS1_k127_5463724_3	1219084.AP014508_gene682	2.613e-10	61.0	COG0281@1|root,COG0281@2|Bacteria,2GCGT@200918|Thermotogae	200918|Thermotogae	C	PFAM malic	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
TLS1_k127_5463724_5	519442.Huta_3014	1.045e-06	50.0	COG0281@1|root,arCOG00853@2157|Archaea,2XSTN@28890|Euryarchaeota,23SK1@183963|Halobacteria	183963|Halobacteria	C	COG0281 Malic enzyme	maeB1	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
TLS1_k127_5463724_4	1459636.NTE_01500	1.394e-09	62.0	COG0281@1|root,arCOG00853@2157|Archaea	2157|Archaea	C	malic enzyme	maeB	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
TLS1_k127_5463724_2	1459636.NTE_01500	5.661e-23	99.0	COG0281@1|root,arCOG00853@2157|Archaea	2157|Archaea	C	malic enzyme	maeB	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
TLS1_k127_5463724_6	1459636.NTE_01500	0.0001086	45.0	COG0281@1|root,arCOG00853@2157|Archaea	2157|Archaea	C	malic enzyme	maeB	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
TLS1_k127_5463724_0	1459636.NTE_01425	5.139e-186	587.0	COG0028@1|root,arCOG01999@2157|Archaea	2157|Archaea	C	Belongs to the TPP enzyme family	-	-	1.2.3.3,1.2.5.1	ko:K00156,ko:K00158	ko00620,ko01100,map00620,map01100	-	R00207,R03145	RC00860,RC02745	ko00000,ko00001,ko01000	-	-	-	Rubredoxin,TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS1_k127_5482555_0	1459636.NTE_02904	3.564e-249	777.0	arCOG01319@1|root,arCOG01319@2157|Archaea	2157|Archaea	S	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
TLS1_k127_5482555_1	1459636.NTE_02911	6.281e-91	312.0	COG0459@1|root,arCOG01257@2157|Archaea,41SDG@651137|Thaumarchaeota	2157|Archaea	O	PFAM TCP-1 cpn60 chaperonin family	thsA	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
TLS1_k127_5501652_0	237368.SCABRO_00224	1.77e-127	424.0	COG1524@1|root,COG1524@2|Bacteria,2IXT6@203682|Planctomycetes	203682|Planctomycetes	S	PFAM type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
TLS1_k127_5501652_1	1197130.BAFM01000021_gene2854	1.98e-32	137.0	COG1082@1|root,arCOG01895@2157|Archaea,2Y2HW@28890|Euryarchaeota,23Z4P@183963|Halobacteria	183963|Halobacteria	G	Xylose isomerase-like TIM barrel	-	-	5.1.3.30,5.1.3.31	ko:K18910	-	-	R10817,R10818	RC03111,RC03283	ko00000,ko01000	-	-	-	AP_endonuc_2
TLS1_k127_5501652_2	1415780.JPOG01000001_gene3342	1.484e-08	57.0	COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,1RR44@1236|Gammaproteobacteria,1X4P9@135614|Xanthomonadales	135614|Xanthomonadales	S	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_33
TLS1_k127_5506861_0	1459636.NTE_02773	3.055e-209	658.0	COG0439@1|root,arCOG01590@2157|Archaea,41SXC@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Carbamoyl-phosphate synthase L chain	-	-	6.4.1.2,6.4.1.3	ko:K18603	ko00720,ko01120,map00720,map01120	-	R00742,R01859	RC00040,RC00097,RC00367,RC00609	ko00000,ko00001,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
TLS1_k127_5506861_2	1459636.NTE_02774	1.598e-47	178.0	COG0511@1|root,arCOG02699@2157|Archaea	2157|Archaea	I	biotin carboxyl carrier	-	-	2.3.1.12,4.1.1.3	ko:K00627,ko:K01571,ko:K15037,ko:K18605	ko00010,ko00020,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200	M00307,M00375,M00741	R00209,R00217,R00742,R01859,R02569	RC00004,RC00040,RC00097,RC00367,RC00609,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,Biotin_lipoyl_2
TLS1_k127_5506861_1	1459636.NTE_02777	5.503e-63	219.0	COG1225@1|root,arCOG00310@2157|Archaea,41SKG@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Redoxin	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
TLS1_k127_5512763_0	1459636.NTE_02889	1.097e-244	764.0	COG0459@1|root,arCOG01257@2157|Archaea,41SDG@651137|Thaumarchaeota	2157|Archaea	O	PFAM TCP-1 cpn60 chaperonin family	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
TLS1_k127_5518660_1	1131266.ARWQ01000001_gene1327	4.36e-72	250.0	COG0603@1|root,arCOG00039@2157|Archaea,41SGR@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Queuosine biosynthesis protein QueC	-	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
TLS1_k127_5518660_0	1459636.NTE_02764	1.105e-82	279.0	COG0302@1|root,arCOG04542@2157|Archaea,41SGC@651137|Thaumarchaeota	651137|Thaumarchaeota	H	GTP cyclohydrolase I	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
TLS1_k127_5518660_2	1459636.NTE_02738	2.944e-36	138.0	COG1384@1|root,arCOG00485@2157|Archaea	1459636.NTE_02738|-	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5518660_3	1459636.NTE_02296	2.852e-21	99.0	arCOG00059@1|root,arCOG00059@2157|Archaea,41T4Y@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5528792_2	1459636.NTE_01767	5.867e-42	158.0	COG0537@1|root,arCOG00419@2157|Archaea,41SNV@651137|Thaumarchaeota	651137|Thaumarchaeota	F	HIT domain	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
TLS1_k127_5528792_0	1459636.NTE_01783	4.285e-265	826.0	COG0129@1|root,arCOG04045@2157|Archaea,41SD0@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
TLS1_k127_5528792_1	1459636.NTE_01984	8.262e-45	163.0	COG0012@1|root,arCOG00357@2157|Archaea,41S8X@651137|Thaumarchaeota	651137|Thaumarchaeota	J	GTPase of unknown function C-terminal	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
TLS1_k127_5539877_0	1459636.NTE_01061	3.541e-40	164.0	arCOG10358@1|root,arCOG10358@2157|Archaea,41SYI@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5561692_1	1459636.NTE_01387	1.225e-66	229.0	COG2147@1|root,arCOG04089@2157|Archaea,41SVC@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Binds to the 23S rRNA	rpl19e	-	-	ko:K02885	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19e
TLS1_k127_5561692_2	1459636.NTE_01386	3.092e-33	132.0	COG0350@1|root,arCOG02724@2157|Archaea,41SR8@651137|Thaumarchaeota	651137|Thaumarchaeota	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1
TLS1_k127_5561692_0	1459636.NTE_01385	1.01e-95	321.0	COG1650@1|root,arCOG01616@2157|Archaea,41SM3@651137|Thaumarchaeota	651137|Thaumarchaeota	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
TLS1_k127_5580157_0	1459636.NTE_02735	5.898e-216	676.0	COG1241@1|root,arCOG00439@2157|Archaea,41SA7@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Belongs to the MCM family	-	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	MCM,MCM_N,MCM_OB
TLS1_k127_5582369_1	1459636.NTE_01298	9.128e-87	293.0	COG0500@1|root,arCOG01631@2157|Archaea,41SJC@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	RNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	DOT1
TLS1_k127_5582369_2	1459636.NTE_03545	4.192e-68	237.0	COG1985@1|root,arCOG01484@2157|Archaea,41SK2@651137|Thaumarchaeota	651137|Thaumarchaeota	H	RibD C-terminal domain	-	-	1.1.1.302	ko:K14654	ko00740,ko01100,map00740,map01100	-	R09375,R09376	RC00933	ko00000,ko00001,ko01000	-	-	-	RibD_C
TLS1_k127_5582369_0	1459636.NTE_03546	4.623e-118	392.0	COG0402@1|root,arCOG00692@2157|Archaea,41S61@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS1_k127_5600387_0	1229909.NSED_01010	1.324e-70	247.0	COG1801@1|root,arCOG04291@2157|Archaea,41T6J@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
TLS1_k127_5600983_0	1459636.NTE_02637	6.643e-97	326.0	COG1405@1|root,arCOG01981@2157|Archaea,41SXZ@651137|Thaumarchaeota	2157|Archaea	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
TLS1_k127_5610597_6	1459636.NTE_02015	6.757e-11	65.0	COG1698@1|root,arCOG04308@2157|Archaea,41SRP@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Belongs to the UPF0147 family	-	-	-	ko:K09721	-	-	-	-	ko00000	-	-	-	UPF0147
TLS1_k127_5610597_5	1459636.NTE_02633	2.287e-56	203.0	COG2178@1|root,arCOG04318@2157|Archaea,41SKR@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Translin family	-	-	-	ko:K07477	-	-	-	-	ko00000	-	-	-	Translin
TLS1_k127_5610597_1	1459636.NTE_02657	3.197e-217	683.0	COG0644@1|root,arCOG00570@2157|Archaea,41SBB@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5610597_0	1459636.NTE_02223	1.232e-226	716.0	COG0449@1|root,arCOG00057@2157|Archaea,41SFG@651137|Thaumarchaeota	651137|Thaumarchaeota	M	TIGRFAM glucosamine--fructose-6-phosphate aminotransferase (isomerizing)	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
TLS1_k127_5610597_2	1459636.NTE_02224	6.665e-121	396.0	COG0640@1|root,arCOG03420@1|root,arCOG01687@2157|Archaea,arCOG03420@2157|Archaea	2157|Archaea	K	PFAM S-layer	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5,S_layer_C
TLS1_k127_5610597_4	1459636.NTE_02225	1.855e-61	215.0	COG0522@1|root,arCOG04239@2157|Archaea,41SN3@651137|Thaumarchaeota	651137|Thaumarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S4
TLS1_k127_5610597_3	1459636.NTE_02226	7.017e-67	231.0	COG0099@1|root,arCOG01722@2157|Archaea,41SIW@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rps13	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
TLS1_k127_5632564_1	1459636.NTE_02171	2.976e-54	199.0	COG1407@1|root,arCOG01150@2157|Archaea,41SJB@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Calcineurin-like phosphoesterase	-	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos
TLS1_k127_5632564_0	1459636.NTE_02172	4.424e-205	645.0	COG0458@1|root,arCOG01594@2157|Archaea,41SBF@651137|Thaumarchaeota	651137|Thaumarchaeota	E	MGS-like domain	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
TLS1_k127_5634893_0	1459636.NTE_01032	2.873e-208	660.0	COG0661@1|root,arCOG01189@2157|Archaea,41SYQ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
TLS1_k127_5634893_2	1459636.NTE_01033	3.749e-29	121.0	arCOG03681@1|root,arCOG03681@2157|Archaea,41T6V@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5634893_3	1128427.KB904821_gene4252	7.237e-28	116.0	COG2154@1|root,COG2154@2|Bacteria,1G992@1117|Cyanobacteria,1HHJQ@1150|Oscillatoriales	1117|Cyanobacteria	H	Pterin 4 alpha carbinolamine dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
TLS1_k127_5634893_1	1459636.NTE_01034	2.065e-37	143.0	COG0494@1|root,arCOG01073@2157|Archaea,41T73@651137|Thaumarchaeota	651137|Thaumarchaeota	L	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
TLS1_k127_5634893_7	1459636.NTE_01034	5.772e-06	51.0	COG0494@1|root,arCOG01073@2157|Archaea,41T73@651137|Thaumarchaeota	651137|Thaumarchaeota	L	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
TLS1_k127_5634893_5	1459636.NTE_02376	2.326e-19	90.0	COG1383@1|root,arCOG01885@2157|Archaea,41SUH@651137|Thaumarchaeota	651137|Thaumarchaeota	J	ribosomal protein	-	-	-	ko:K02962	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17e
TLS1_k127_5634893_6	1459636.NTE_02377	9.605e-15	77.0	COG1617@1|root,COG1977@1|root,arCOG00536@2157|Archaea,arCOG02197@2157|Archaea,41SSW@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Kinase binding protein CGI-121	-	-	-	-	-	-	-	-	-	-	-	-	CGI-121,ThiS
TLS1_k127_5634893_4	1459636.NTE_02377	2.3e-21	102.0	COG1617@1|root,COG1977@1|root,arCOG00536@2157|Archaea,arCOG02197@2157|Archaea,41SSW@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Kinase binding protein CGI-121	-	-	-	-	-	-	-	-	-	-	-	-	CGI-121,ThiS
TLS1_k127_5636351_2	1459636.NTE_02735	1.774e-79	268.0	COG1241@1|root,arCOG00439@2157|Archaea,41SA7@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Belongs to the MCM family	-	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	MCM,MCM_N,MCM_OB
TLS1_k127_5636351_3	1459636.NTE_02736	3.819e-54	196.0	arCOG00552@1|root,arCOG00552@2157|Archaea,41SRW@651137|Thaumarchaeota	651137|Thaumarchaeota	L	GINS complex protein	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	Sld5
TLS1_k127_5636351_1	1459636.NTE_03103	4.428e-233	735.0	COG1164@1|root,arCOG04758@2157|Archaea,41S7J@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Peptidase family M3	-	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
TLS1_k127_5636351_0	1459636.NTE_03216	4.678e-275	856.0	COG0525@1|root,arCOG00808@2157|Archaea,41SBK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Anticodon-binding domain of tRNA	-	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
TLS1_k127_5665412_1	1459636.NTE_01495	3.987e-87	295.0	COG1653@1|root,arCOG00151@2157|Archaea	2157|Archaea	G	COG1653 ABC-type sugar transport system, periplasmic component	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
TLS1_k127_5665412_3	7668.SPU_006427-tr	0.0008731	44.0	KOG1721@1|root,KOG1721@2759|Eukaryota,38BN0@33154|Opisthokonta	33154|Opisthokonta	K	DNA binding	PZF1	GO:0000182,GO:0000976,GO:0000992,GO:0001002,GO:0001016,GO:0001025,GO:0001030,GO:0001067,GO:0001156,GO:0003674,GO:0003676,GO:0003677,GO:0003682,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005700,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006351,GO:0006355,GO:0006383,GO:0006725,GO:0006807,GO:0007049,GO:0008134,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009303,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022402,GO:0031323,GO:0031326,GO:0031490,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0034660,GO:0042023,GO:0042791,GO:0043035,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0044786,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0060968,GO:0065007,GO:0071704,GO:0080084,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0098781,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:1990837,GO:2000112,GO:2001141	-	ko:K09191	-	-	-	-	ko00000,ko03000,ko03021	-	-	-	zf-AD,zf-C2H2,zf-C2H2_6,zf-met
TLS1_k127_5665412_2	1459636.NTE_01307	8.001e-38	145.0	arCOG10523@1|root,arCOG10523@2157|Archaea,41SSZ@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5665412_0	1459636.NTE_02742	1.617e-193	610.0	COG0672@1|root,arCOG04330@2157|Archaea,41T07@651137|Thaumarchaeota	651137|Thaumarchaeota	P	High-affinity Fe2 Pb2 permease	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1
TLS1_k127_5665563_1	1459636.NTE_00004	2.735e-21	102.0	COG0468@1|root,arCOG00415@2157|Archaea	2157|Archaea	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	-	-	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Rad51
TLS1_k127_5665563_0	1121422.AUMW01000013_gene1444	2.799e-27	119.0	COG0461@1|root,COG0461@2|Bacteria,1V1BZ@1239|Firmicutes,24AS1@186801|Clostridia	186801|Clostridia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
TLS1_k127_5682615_2	1136417.AZWE01000006_gene4344	1.506e-05	47.0	COG2146@1|root,COG2146@2|Bacteria,2IQK7@201174|Actinobacteria	201174|Actinobacteria	P	Rieske 2Fe-2S	sufE	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
TLS1_k127_5682615_0	1459636.NTE_01150	5.775e-141	455.0	COG0346@1|root,arCOG03101@2157|Archaea	2157|Archaea	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	-	ko:K15975	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS1_k127_5682615_1	1459636.NTE_01151	1.525e-44	165.0	arCOG06256@1|root,arCOG06256@2157|Archaea	2157|Archaea	S	phospholipase Carboxylesterase	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2
TLS1_k127_5686268_1	1459636.NTE_01634	5.424e-79	266.0	COG0358@1|root,arCOG04281@2157|Archaea,41S75@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA primase	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
TLS1_k127_5686268_2	1459636.NTE_01633	1.071e-38	151.0	COG1658@1|root,arCOG01486@2157|Archaea,41SU4@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Toprim domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5686268_3	436308.Nmar_1318	5.187e-16	82.0	COG1826@1|root,arCOG02694@2157|Archaea,41SRR@651137|Thaumarchaeota	651137|Thaumarchaeota	U	mttA/Hcf106 family	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
TLS1_k127_5686268_0	1459636.NTE_02631	9.304e-117	379.0	COG0334@1|root,arCOG01352@2157|Archaea,41S7T@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
TLS1_k127_5699053_5	1459636.NTE_01657	3.394e-25	107.0	COG2092@1|root,arCOG01988@2157|Archaea,41SS1@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA	ef1b	-	-	ko:K03232	-	-	-	-	ko00000,ko03012	-	-	-	EF1_GNE
TLS1_k127_5699053_4	1459636.NTE_01656	1.123e-31	123.0	COG2888@1|root,arCOG01989@2157|Archaea,41T83@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Zn-ribbon RNA-binding protein with a function in translation	-	-	-	ko:K07580	-	-	-	-	ko00000	-	-	-	-
TLS1_k127_5699053_1	1459636.NTE_01655	1.045e-59	212.0	COG0644@1|root,arCOG00570@2157|Archaea,41SB5@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5699053_2	1459636.NTE_01655	5.944e-53	193.0	COG0644@1|root,arCOG00570@2157|Archaea,41SB5@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5699053_3	1459636.NTE_01654	1.3e-38	149.0	COG1990@1|root,arCOG04228@2157|Archaea,41ST1@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Peptidyl-tRNA hydrolase PTH2	-	-	3.1.1.29	ko:K04794	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	PTH2
TLS1_k127_5699053_0	1459636.NTE_00759	1.238e-182	580.0	COG1027@1|root,COG1670@1|root,arCOG00842@2157|Archaea,arCOG01750@2157|Archaea,41S9C@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Fumarase C C-terminus	-	-	4.3.1.1	ko:K01744	ko00250,ko01100,map00250,map01100	-	R00490	RC00316,RC02799	ko00000,ko00001,ko01000	-	-	-	FumaraseC_C,Lyase_1
TLS1_k127_5711776_1	218851.Aquca_049_00105.1	3.749e-05	48.0	COG0159@1|root,KOG4175@2759|Eukaryota,37QAU@33090|Viridiplantae,3GCHM@35493|Streptophyta	35493|Streptophyta	E	Belongs to the TrpA family	-	-	4.1.2.8,4.2.1.20	ko:K01695,ko:K13222	ko00260,ko00400,ko00402,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map00402,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
TLS1_k127_5817962_2	1459636.NTE_03220	1.285e-41	154.0	COG0519@1|root,arCOG00085@2157|Archaea,41SDI@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
TLS1_k127_5817962_1	1459636.NTE_03219	6.818e-54	198.0	arCOG05463@1|root,arCOG05463@2157|Archaea,41SR3@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5817962_0	1459636.NTE_03217	1.36e-84	287.0	COG1634@1|root,arCOG04303@2157|Archaea,41SKX@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP)	mptE	-	2.7.6.3	ko:K07142	ko00790,map00790	-	R03503	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	MAF_flag10
TLS1_k127_5845621_1	1121859.KB890760_gene2098	1.548e-82	275.0	COG0735@1|root,COG0735@2|Bacteria,4NM8S@976|Bacteroidetes,47P99@768503|Cytophagia	976|Bacteroidetes	P	Belongs to the Fur family	fur	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
TLS1_k127_5845621_2	1237149.C900_00191	1.955e-38	146.0	COG1366@1|root,COG1366@2|Bacteria,4NTNE@976|Bacteroidetes,47R73@768503|Cytophagia	976|Bacteroidetes	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
TLS1_k127_5845621_0	1237149.C900_00190	6.078e-200	629.0	COG0104@1|root,COG0104@2|Bacteria,4NGRZ@976|Bacteroidetes,47JQ0@768503|Cytophagia	976|Bacteroidetes	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
TLS1_k127_5845621_4	1453505.JASY01000008_gene954	4.774e-08	55.0	2DRUD@1|root,33D3V@2|Bacteria,4NY0I@976|Bacteroidetes,1I6KN@117743|Flavobacteriia,2NY5F@237|Flavobacterium	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5845621_3	1392489.JPOL01000002_gene333	2.477e-22	96.0	2EH3B@1|root,33AVB@2|Bacteria,4NXP5@976|Bacteroidetes,1I6KT@117743|Flavobacteriia,2XKF9@283735|Leeuwenhoekiella	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5854154_4	1459636.NTE_02478	2.507e-05	46.0	COG0836@1|root,arCOG02427@2157|Archaea	2157|Archaea	M	TIGRFAM Mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase	manC	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0229	MannoseP_isomer,NTP_transferase
TLS1_k127_5854154_0	1459636.NTE_02856	4.502e-241	749.0	COG5256@1|root,arCOG01561@2157|Archaea,41SD2@651137|Thaumarchaeota	651137|Thaumarchaeota	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
TLS1_k127_5854154_2	1459636.NTE_02855	8.317e-56	195.0	COG0051@1|root,arCOG01758@2157|Archaea,41SQB@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Involved in the binding of tRNA to the ribosomes	rps10	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
TLS1_k127_5854154_3	1459636.NTE_02088	4.881e-25	108.0	arCOG11950@1|root,arCOG11950@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	bPH_3
TLS1_k127_5854154_1	1459636.NTE_00682	4.331e-206	653.0	COG0417@1|root,arCOG15272@2157|Archaea,41S91@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA polymerase	-	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1
TLS1_k127_5859068_1	1459636.NTE_03510	1.335e-107	359.0	COG0861@1|root,arCOG09430@2157|Archaea	2157|Archaea	P	PFAM Integral membrane protein TerC	-	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
TLS1_k127_5859068_0	1459636.NTE_02661	3.257e-138	453.0	COG1254@1|root,arCOG00643@2157|Archaea	2157|Archaea	C	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C,Acylphosphatase
TLS1_k127_5980059_1	1459636.NTE_01926	1.237e-45	172.0	COG0784@1|root,arCOG02391@2157|Archaea,41T5D@651137|Thaumarchaeota	651137|Thaumarchaeota	T	Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS1_k127_5980059_2	1459636.NTE_03327	2.344e-20	98.0	arCOG08764@1|root,arCOG08764@2157|Archaea,41TBI@651137|Thaumarchaeota	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_5980059_0	521011.Mpal_2369	7.063e-90	306.0	COG3391@1|root,arCOG02516@1|root,arCOG02516@2157|Archaea,arCOG03563@2157|Archaea,2Y7Y4@28890|Euryarchaeota,2NBN4@224756|Methanomicrobia	2157|Archaea	S	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,HemolysinCabind,Kelch_4,NHL,PKD
TLS1_k127_6001537_2	1459636.NTE_01024	2.465e-09	63.0	arCOG03788@1|root,arCOG03788@2157|Archaea,41T96@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_6001537_0	1459636.NTE_01238	1.499e-40	150.0	COG1522@1|root,arCOG01117@2157|Archaea	1459636.NTE_01238|-	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_6001537_3	1131266.ARWQ01000009_gene938	0.0001561	44.0	COG1303@1|root,arCOG01857@2157|Archaea,41SIR@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs	-	-	2.1.1.206	ko:K07254	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Trm56
TLS1_k127_6019010_4	1459636.NTE_01697	7.318e-17	83.0	COG3269@1|root,arCOG01641@2157|Archaea	2157|Archaea	J	RNA-binding protein contains TRAM domain	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
TLS1_k127_6019010_2	1459636.NTE_03005	9.019e-24	107.0	COG0589@1|root,arCOG02053@2157|Archaea,41T8M@651137|Thaumarchaeota	651137|Thaumarchaeota	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS1_k127_6019010_5	1229909.NSED_03480	1.107e-09	65.0	COG0517@1|root,arCOG00606@2157|Archaea	2157|Archaea	I	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS1_k127_6019010_1	1459636.NTE_03044	1.434e-35	139.0	arCOG08654@1|root,arCOG08654@2157|Archaea,41SRM@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_6019010_6	1236973.JCM9157_1352	0.0001026	48.0	COG2905@1|root,COG2905@2|Bacteria,1VW3X@1239|Firmicutes,4HJ81@91061|Bacilli,1ZH6S@1386|Bacillus	91061|Bacilli	T	COG0517 FOG CBS domain	ylbB	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS1_k127_6030050_0	1122603.ATVI01000005_gene2887	2.075e-58	221.0	COG1228@1|root,COG1228@2|Bacteria,1MY4V@1224|Proteobacteria,1RZRK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS1_k127_6030050_1	1459636.NTE_01128	1.564e-17	84.0	arCOG00516@1|root,arCOG00516@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS1_k127_6030050_2	868131.MSWAN_1879	2.246e-16	82.0	COG1695@1|root,arCOG00002@2157|Archaea	2157|Archaea	K	PFAM transcriptional regulator PadR family protein	-	-	-	-	-	-	-	-	-	-	-	-	PadR
TLS1_k127_6049505_0	1123376.AUIU01000012_gene1357	1.081e-39	152.0	COG2110@1|root,COG2110@2|Bacteria	2|Bacteria	P	phosphatase homologous to the C-terminal domain of histone macroH2A1	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	Macro
TLS1_k127_6049505_2	1120985.AUMI01000017_gene2613	7.376e-07	54.0	COG2110@1|root,COG2110@2|Bacteria,1TPCU@1239|Firmicutes,4H4GW@909932|Negativicutes	909932|Negativicutes	S	Appr-1'-p processing enzyme	ymdB	-	-	-	-	-	-	-	-	-	-	-	Macro
TLS1_k127_6049505_1	240302.BN982_02834	2.491e-18	90.0	COG4122@1|root,COG4122@2|Bacteria,1V4A3@1239|Firmicutes,4HGWV@91061|Bacilli,3NESR@45667|Halobacillus	91061|Bacilli	S	O-methyltransferase	mdmC3	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
TLS1_k127_6116911_1	1459636.NTE_02045	0.0009137	51.0	arCOG14091@1|root,arCOG14091@2157|Archaea,41T6X@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_6116911_0	1459636.NTE_02263	5.975e-78	264.0	COG1608@1|root,arCOG00860@2157|Archaea,41SI4@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Amino acid kinase family	-	-	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
TLS1_k127_6128125_0	1229909.NSED_03360	1.078e-98	334.0	COG4608@1|root,arCOG00184@2157|Archaea,41S9E@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS1_k127_6128125_1	1459636.NTE_01644	9.14e-81	275.0	COG1196@1|root,arCOG00371@2157|Archaea,41SDS@651137|Thaumarchaeota	651137|Thaumarchaeota	D	SMC proteins Flexible Hinge Domain	-	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
TLS1_k127_615866_4	262723.MS53_0364	3.059e-10	65.0	COG0030@1|root,COG0030@2|Bacteria,3WTCB@544448|Tenericutes	544448|Tenericutes	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
TLS1_k127_615866_0	1459636.NTE_01094	1.512e-89	299.0	COG1491@1|root,arCOG04130@2157|Archaea,41SGD@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Protein of unknown function (DUF655)	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
TLS1_k127_615866_2	1459636.NTE_01093	6.332e-37	141.0	COG1460@1|root,arCOG01016@2157|Archaea,41SQ1@651137|Thaumarchaeota	651137|Thaumarchaeota	K	RNA polymerase Rpb4	-	-	2.7.7.6	ko:K03051	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb4
TLS1_k127_615866_3	1459636.NTE_01092	1.09e-35	138.0	COG2139@1|root,arCOG04129@2157|Archaea,41SRF@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the eukaryotic ribosomal protein eL21 family	rpl21e	-	-	ko:K02889	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21e
TLS1_k127_615866_1	1459636.NTE_01091	4.52e-58	203.0	COG0468@1|root,arCOG00415@2157|Archaea,41SBA@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	-	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Rad51
TLS1_k127_6160639_0	1459636.NTE_02172	6.454e-251	790.0	COG0458@1|root,arCOG01594@2157|Archaea,41SBF@651137|Thaumarchaeota	651137|Thaumarchaeota	E	MGS-like domain	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
TLS1_k127_6171656_3	1459636.NTE_03034	1.926e-47	173.0	COG2125@1|root,arCOG01946@2157|Archaea,41SPC@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the eukaryotic ribosomal protein eS6 family	rps6e	-	-	ko:K02991	ko01521,ko03010,ko04066,ko04150,ko04151,ko04371,ko04714,ko04910,ko05205,map01521,map03010,map04066,map04150,map04151,map04371,map04714,map04910,map05205	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S6e
TLS1_k127_6171656_4	1459636.NTE_03033	1.087e-14	75.0	arCOG08820@1|root,arCOG08820@2157|Archaea,41SWF@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_6171656_1	1459636.NTE_03161	1.912e-134	440.0	COG0399@1|root,arCOG00118@2157|Archaea,41S96@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
TLS1_k127_6171656_0	1459636.NTE_03163	1.264e-135	442.0	COG0003@1|root,COG0071@1|root,arCOG01833@2157|Archaea,arCOG02849@2157|Archaea	2157|Archaea	P	Arsenite-activated ATPase ArsA	arsA4	-	3.6.3.16	ko:K01551,ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko01000,ko02000,ko03110	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
TLS1_k127_6171656_2	1459636.NTE_00031	7.384e-49	177.0	COG0864@1|root,arCOG01008@2157|Archaea,41SQM@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Ribbon-helix-helix protein, copG family	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
TLS1_k127_6228368_0	1459636.NTE_02605	9.36e-267	839.0	COG0464@1|root,arCOG01308@2157|Archaea,41SX8@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
TLS1_k127_6269600_0	1459636.NTE_03346	7.091e-172	552.0	COG1061@1|root,arCOG00874@2157|Archaea,41SW0@651137|Thaumarchaeota	2157|Archaea	K	Type III restriction enzyme, res subunit	rad25	-	-	-	-	-	-	-	-	-	-	-	ERCC3_RAD25_C,Helicase_C,ResIII
TLS1_k127_6345903_0	1459636.NTE_01791	3.959e-132	428.0	COG0502@1|root,arCOG00658@2157|Archaea,41S9Y@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
TLS1_k127_6345903_2	1459636.NTE_01789	7.265e-33	130.0	arCOG08722@1|root,arCOG08722@2157|Archaea,41SSI@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_6345903_1	1459636.NTE_01106	4.292e-66	237.0	COG0367@1|root,arCOG04741@1|root,arCOG00071@2157|Archaea,arCOG04741@2157|Archaea,41SMA@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase
TLS1_k127_6345903_3	1459636.NTE_01573	6.938e-10	64.0	COG3432@1|root,arCOG01055@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
TLS1_k127_6345903_4	1459636.NTE_01785	0.0001746	44.0	COG0498@1|root,arCOG01434@2157|Archaea,41S5N@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS1_k127_6369146_0	1459636.NTE_01584	1.272e-146	467.0	COG0119@1|root,arCOG02092@2157|Archaea,41S7Y@651137|Thaumarchaeota	651137|Thaumarchaeota	E	HMGL-like	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
TLS1_k127_6369146_2	931277.C448_06118	1.171e-14	79.0	COG1522@1|root,arCOG01580@2157|Archaea,2XX5M@28890|Euryarchaeota,23VKV@183963|Halobacteria	183963|Halobacteria	K	COG1522 Transcriptional regulators	trh3	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_AsnC-type
TLS1_k127_6369146_1	1459636.NTE_00736	4.811e-113	370.0	COG4992@1|root,arCOG00914@2157|Archaea,41SC8@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	lysJ	-	-	ko:K05830	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00031,M00763	R09778,R10932	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS1_k127_6369774_1	1459636.NTE_02175	9.68e-133	431.0	COG0473@1|root,arCOG01163@2157|Archaea,41SAA@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Isocitrate isopropylmalate dehydrogenase	-	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TLS1_k127_6369774_2	1459636.NTE_02177	1.952e-72	247.0	COG0440@1|root,arCOG04445@2157|Archaea,41SNS@651137|Thaumarchaeota	651137|Thaumarchaeota	E	acetolactate synthase, small	-	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
TLS1_k127_6369774_0	1459636.NTE_02178	2.262e-182	573.0	COG0028@1|root,arCOG01998@2157|Archaea,41S63@651137|Thaumarchaeota	651137|Thaumarchaeota	E	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS1_k127_6371020_0	1459636.NTE_02484	1.301e-296	923.0	COG0178@1|root,arCOG04694@2157|Archaea,41T01@651137|Thaumarchaeota	651137|Thaumarchaeota	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
TLS1_k127_6371020_1	1459636.NTE_02483	3.399e-293	912.0	COG0556@1|root,arCOG04748@2157|Archaea,41T0H@651137|Thaumarchaeota	651137|Thaumarchaeota	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
TLS1_k127_6412523_1	1459636.NTE_01462	2.335e-56	203.0	arCOG08742@1|root,arCOG08742@2157|Archaea,41SS8@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_6412523_3	1459636.NTE_01460	2.533e-18	93.0	COG1374@1|root,arCOG00993@2157|Archaea	2157|Archaea	J	Protein involved in ribosomal biogenesis, contains PUA domain	-	-	-	ko:K07565	-	-	-	-	ko00000,ko03009	-	-	-	UPF0113
TLS1_k127_6412523_0	1459636.NTE_01459	1.705e-96	325.0	COG0144@1|root,arCOG00973@2157|Archaea	2157|Archaea	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	-	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016427,GO:0016428,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	-	-	-	-	-	-	-	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N
TLS1_k127_6412523_2	1229909.NSED_03175	7.059e-24	103.0	COG2042@1|root,arCOG04733@2157|Archaea,41SMC@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Ribosome biogenesis protein, C-terminal	-	-	-	ko:K09140	-	-	-	-	ko00000,ko03009	-	-	-	RLI,Ribo_biogen_C
TLS1_k127_6462361_2	1459636.NTE_01424	1.033e-26	108.0	COG1146@1|root,arCOG08753@1|root,arCOG04548@2157|Archaea,arCOG08753@2157|Archaea,41SH5@651137|Thaumarchaeota	651137|Thaumarchaeota	C	ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
TLS1_k127_6462361_1	1459636.NTE_01359	1.455e-41	161.0	arCOG03737@1|root,arCOG03737@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_6462361_0	1459636.NTE_01360	1.996e-146	481.0	COG0640@1|root,arCOG00472@2157|Archaea	2157|Archaea	K	PFAM regulatory protein, ArsR	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_16,AAA_22,DUF2791,HTH_5
TLS1_k127_6500646_5	1459636.NTE_02163	7.246e-11	70.0	arCOG08635@1|root,arCOG08635@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_6500646_3	1459636.NTE_02162	3.385e-26	108.0	COG2126@1|root,arCOG04126@2157|Archaea,41T9V@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Binds to the 23S rRNA	rpl37e	-	-	ko:K02922	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37e
TLS1_k127_6500646_2	1459636.NTE_02161	4.873e-39	146.0	COG1958@1|root,arCOG00998@2157|Archaea,41SU9@651137|Thaumarchaeota	651137|Thaumarchaeota	K	snRNP Sm proteins	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
TLS1_k127_6500646_1	1459636.NTE_02160	9.665e-81	275.0	COG1402@1|root,arCOG04536@2157|Archaea,41SNC@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
TLS1_k127_6500646_0	1459636.NTE_02159	2.228e-125	407.0	COG0788@1|root,arCOG02826@2157|Archaea,41S78@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Formyl transferase	-	-	3.5.1.10	ko:K01433	ko00630,ko00670,map00630,map00670	-	R00944	RC00026,RC00111	ko00000,ko00001,ko01000	-	-	-	ACT_6,Formyl_trans_N
TLS1_k127_6546933_0	1459636.NTE_03053	1.568e-258	805.0	COG0155@1|root,arCOG02055@2157|Archaea,41S5Q@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Sulfite reductase	-	-	1.8.7.1	ko:K00392	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00859,R03600	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
TLS1_k127_6546933_1	1459636.NTE_02459	4.606e-158	504.0	COG0499@1|root,arCOG04137@2157|Archaea,41S9I@651137|Thaumarchaeota	2157|Archaea	H	S-adenosyl-L-homocysteine hydrolase, NAD binding domain	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
TLS1_k127_6641124_1	1459636.NTE_01915	2.19e-146	473.0	COG1474@1|root,arCOG00467@2157|Archaea,41SED@651137|Thaumarchaeota	2157|Archaea	L	Involved in regulation of DNA replication	-	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_22
TLS1_k127_6641124_2	1459636.NTE_01916	2.656e-20	93.0	COG0640@1|root,arCOG04056@2157|Archaea	2157|Archaea	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24,HTH_5,TrmB
TLS1_k127_6641124_0	1459636.NTE_01920	8.237e-168	533.0	COG0504@1|root,arCOG00063@2157|Archaea,41S7G@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
TLS1_k127_6663755_2	1459636.NTE_01424	1.033e-26	108.0	COG1146@1|root,arCOG08753@1|root,arCOG04548@2157|Archaea,arCOG08753@2157|Archaea,41SH5@651137|Thaumarchaeota	651137|Thaumarchaeota	C	ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
TLS1_k127_6663755_1	1459636.NTE_01423	1.876e-44	166.0	COG1986@1|root,arCOG01223@2157|Archaea,41SKV@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Cytidylyltransferase-like	-	-	2.7.7.3	ko:K02201	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
TLS1_k127_6663755_0	1459636.NTE_01420	2.735e-144	462.0	COG0180@1|root,arCOG01887@2157|Archaea,41SDK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
TLS1_k127_6687770_0	1459636.NTE_00109	1.125e-213	681.0	COG0640@1|root,COG1328@1|root,arCOG00734@2157|Archaea,arCOG04889@2157|Archaea,41SBG@651137|Thaumarchaeota	651137|Thaumarchaeota	FK	Anaerobic ribonucleoside-triphosphate reductase	-	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,HTH_20,NRDD
TLS1_k127_6687770_1	1459636.NTE_00108	3.587e-16	82.0	COG5491@1|root,arCOG00452@2157|Archaea	2157|Archaea	N	conserved protein implicated in secretion	-	-	-	-	-	-	-	-	-	-	-	-	Snf7
TLS1_k127_6690554_4	1459636.NTE_01588	4.308e-49	177.0	COG2151@1|root,arCOG01845@2157|Archaea,41SQV@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Iron-sulfur cluster assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
TLS1_k127_6690554_1	1459636.NTE_01591	1.323e-116	381.0	COG0479@1|root,arCOG00962@2157|Archaea,41SAW@651137|Thaumarchaeota	651137|Thaumarchaeota	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
TLS1_k127_6690554_5	1459636.NTE_01592	1.497e-40	152.0	COG2142@1|root,arCOG04162@2157|Archaea,41SRA@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	-	-	-	ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
TLS1_k127_6690554_3	1459636.NTE_01593	3.927e-70	240.0	COG2009@1|root,arCOG02244@2157|Archaea,41SKZ@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	-	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
TLS1_k127_6690554_0	1459636.NTE_01594	3.14e-305	942.0	COG1053@1|root,arCOG00571@2157|Archaea,41SAM@651137|Thaumarchaeota	651137|Thaumarchaeota	C	fumarate reductase flavoprotein	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TLS1_k127_6690554_2	1459636.NTE_01603	3.745e-112	372.0	COG0124@1|root,arCOG00404@2157|Archaea,41S9T@651137|Thaumarchaeota	651137|Thaumarchaeota	J	histidyl-tRNA synthetase	-	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
TLS1_k127_66915_3	944481.JAFP01000001_gene602	1.6e-18	86.0	COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,42R30@68525|delta/epsilon subdivisions,2WJT0@28221|Deltaproteobacteria,2M6N0@213113|Desulfurellales	28221|Deltaproteobacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
TLS1_k127_66915_2	632245.CLP_3893	6.431e-32	132.0	COG0212@1|root,COG0212@2|Bacteria,1VA91@1239|Firmicutes,24N7H@186801|Clostridia,36JPF@31979|Clostridiaceae	186801|Clostridia	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	fthC	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
TLS1_k127_66915_0	1131266.ARWQ01000014_gene81	2.22e-130	429.0	COG0151@1|root,arCOG04415@2157|Archaea,41SB3@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
TLS1_k127_66915_1	1459636.NTE_02055	2.338e-35	137.0	COG1400@1|root,arCOG01217@2157|Archaea,41SR5@651137|Thaumarchaeota	651137|Thaumarchaeota	U	SRP19 protein	-	-	-	ko:K03105	ko03060,map03060	-	-	-	ko00000,ko00001,ko02044	3.A.5.7,3.A.5.9	-	-	SRP19
TLS1_k127_6703508_2	1459636.NTE_00971	2.056e-35	143.0	COG0500@1|root,arCOG01787@2157|Archaea	2157|Archaea	Q	PFAM Methyltransferase type	-	-	-	ko:K15256	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_12,Methyltransf_25,Methyltransf_31
TLS1_k127_6703508_1	1459636.NTE_00970	8.292e-88	293.0	COG2151@1|root,arCOG03838@1|root,arCOG01845@2157|Archaea,arCOG03838@2157|Archaea,41SHR@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Coenzyme PQQ synthesis protein D (PqqD)	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P,PqqD
TLS1_k127_6703508_0	1459636.NTE_00969	2.082e-126	413.0	COG0182@1|root,arCOG01123@2157|Archaea,41SF9@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	-	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
TLS1_k127_6703508_3	1459636.NTE_00968	4.472e-21	96.0	COG0677@1|root,arCOG00252@2157|Archaea	2157|Archaea	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	wecC	-	1.1.1.336	ko:K02472	ko00520,ko05111,map00520,map05111	-	R03317	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
TLS1_k127_6733678_1	1459636.NTE_00859	1.045e-08	59.0	COG4742@1|root,arCOG04362@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS1_k127_6733678_0	1459636.NTE_02245	3.995e-68	242.0	arCOG07810@1|root,arCOG07810@2157|Archaea,41T26@651137|Thaumarchaeota	1459636.NTE_02245|-	T	PFAM Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	-
TLS1_k127_684059_0	1459636.NTE_03283	6.535e-183	591.0	COG1293@1|root,arCOG01695@2157|Archaea,41SB0@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Fibronectin-binding protein A N-terminus (FbpA)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
TLS1_k127_684059_1	1459636.NTE_03282	1.782e-79	269.0	COG0517@1|root,arCOG00606@2157|Archaea	2157|Archaea	I	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS1_k127_684059_4	1459636.NTE_03281	1.415e-28	122.0	COG1656@1|root,arCOG04290@2157|Archaea,41T65@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C
TLS1_k127_684059_3	1459636.NTE_03280	4.94e-56	203.0	COG1390@1|root,arCOG00869@2157|Archaea,41T4W@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
TLS1_k127_684059_2	1459636.NTE_03279	8.007e-79	265.0	COG1155@1|root,arCOG00868@2157|Archaea,41SZU@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
TLS1_k127_6882542_0	1459636.NTE_01905	1.053e-138	449.0	COG0057@1|root,arCOG00493@2157|Archaea,41SDF@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	-	-	1.2.1.59	ko:K00150	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166	R01061,R01063	RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	-
TLS1_k127_6882542_1	1459636.NTE_01906	2.028e-78	266.0	COG0512@1|root,arCOG00086@2157|Archaea,41SGV@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Glutamine amidotransferase of anthranilate synthase	-	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
TLS1_k127_6882542_2	1459636.NTE_01907	1.679e-45	171.0	COG0547@1|root,arCOG02012@2157|Archaea,41SGG@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
TLS1_k127_6891675_2	32057.KB217478_gene7446	6.979e-15	80.0	COG5485@1|root,COG5485@2|Bacteria,1GEUM@1117|Cyanobacteria	1117|Cyanobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
TLS1_k127_6891675_1	1459636.NTE_00051	9.483e-97	322.0	COG0125@1|root,arCOG01891@2157|Archaea	2157|Archaea	F	thymidylate kinase	-	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
TLS1_k127_6891675_0	1459636.NTE_00052	3.459e-98	329.0	COG0125@1|root,arCOG01891@2157|Archaea	1459636.NTE_00052|-	F	thymidylate kinase	-	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	-
TLS1_k127_7002383_0	1459636.NTE_01051	3.286e-248	778.0	COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,41S6N@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Succinyl-CoA ligase like flavodoxin domain	-	-	-	ko:K18593	ko00720,ko01120,map00720,map01120	-	R10758	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
TLS1_k127_7093203_1	1380370.JIBA01000018_gene455	2.373e-09	67.0	COG1226@1|root,COG1226@2|Bacteria,2GKNF@201174|Actinobacteria,4FGSW@85021|Intrasporangiaceae	201174|Actinobacteria	P	Ion transport protein	kcsA	GO:0003674,GO:0005215,GO:0005216,GO:0005244,GO:0005249,GO:0005261,GO:0005267,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0022803,GO:0022832,GO:0022836,GO:0022838,GO:0022839,GO:0022843,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2
TLS1_k127_7093203_0	1459636.NTE_00844	4.694e-76	265.0	COG1335@1|root,arCOG01943@2157|Archaea	2157|Archaea	Q	COG1335 Amidases related to nicotinamidase	-	-	3.5.1.110	ko:K09020	ko00240,ko01100,map00240,map01100	-	R09947,R09980	RC02737,RC02738	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
TLS1_k127_7110249_0	1459636.NTE_01187	6.536e-39	146.0	COG1522@1|root,arCOG01117@2157|Archaea,41ST7@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
TLS1_k127_7110249_2	1459636.NTE_00426	1.171e-21	97.0	arCOG08809@1|root,arCOG08809@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7110249_1	1459636.NTE_00425	1.25e-34	140.0	COG1711@1|root,arCOG00551@2157|Archaea,41SVQ@651137|Thaumarchaeota	651137|Thaumarchaeota	L	protein conserved in archaea	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	-
TLS1_k127_7124911_0	1459636.NTE_01081	3.189e-267	836.0	COG1389@1|root,arCOG01165@2157|Archaea,41SJ2@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	-	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,Topo-VIb_trans
TLS1_k127_7124911_1	1459636.NTE_01080	3.521e-199	625.0	COG1697@1|root,arCOG04143@2157|Archaea,41SQF@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6A	-	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	TP6A_N
TLS1_k127_714038_0	1459636.NTE_01711	1.911e-127	424.0	COG0277@1|root,arCOG00337@2157|Archaea,41T0E@651137|Thaumarchaeota	651137|Thaumarchaeota	C	FAD linked	-	-	-	-	-	-	-	-	-	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS1_k127_714038_2	1459636.NTE_01559	2.958e-48	181.0	COG2094@1|root,arCOG04295@2157|Archaea,41SME@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Belongs to the DNA glycosylase MPG family	-	-	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
TLS1_k127_714038_1	1459636.NTE_00636	2.944e-85	288.0	COG0524@1|root,arCOG00014@2157|Archaea,41SX4@651137|Thaumarchaeota	651137|Thaumarchaeota	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
TLS1_k127_7169134_0	1459636.NTE_02474	1.436e-148	476.0	COG0644@1|root,COG2440@1|root,arCOG00570@2157|Archaea,arCOG01984@2157|Archaea,41SXJ@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	-	ko:K00313	-	-	-	-	ko00000,ko01000	-	-	-	-
TLS1_k127_7169134_1	1459636.NTE_02473	2.89e-69	239.0	COG0526@1|root,arCOG00314@2157|Archaea,41SKE@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS1_k127_7175005_2	1459636.NTE_01955	8.325e-53	195.0	COG0169@1|root,arCOG02097@2157|Archaea,41SKU@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate	aroD	-	4.2.1.10	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I
TLS1_k127_7175005_0	1459636.NTE_01958	2.083e-155	494.0	COG0863@1|root,arCOG00115@2157|Archaea,41SZP@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA methylase	-	-	2.1.1.113,2.1.1.72	ko:K00571,ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
TLS1_k127_7175005_1	1459636.NTE_01959	2.658e-120	395.0	COG1465@1|root,arCOG04353@2157|Archaea,41S88@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis	aroB'	-	1.4.1.24	ko:K11646	ko00400,ko01110,ko01130,map00400,map01110,map01130	-	R08569	RC02302	ko00000,ko00001,ko01000	-	-	-	DHQS
TLS1_k127_7175005_3	1459636.NTE_01960	4.066e-49	177.0	COG1830@1|root,arCOG04044@2157|Archaea,41SCP@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids	aroA'	-	2.2.1.10,4.1.2.13	ko:K16306	ko00010,ko00030,ko00051,ko00400,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00400,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001	R01068,R01070,R02568,R08568	RC00438,RC00439,RC00721,RC02301	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
TLS1_k127_7277412_0	598467.BrE312_0530	5.925e-74	270.0	COG0596@1|root,COG0596@2|Bacteria,1MUVB@1224|Proteobacteria,1RQE0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS1_k127_7277412_2	1459636.NTE_01713	2.455e-41	156.0	COG0346@1|root,arCOG02708@2157|Archaea,41SU3@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Glyoxalase-like domain	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase,Glyoxalase_2
TLS1_k127_7277412_1	1459636.NTE_01667	1.594e-49	179.0	arCOG08684@1|root,arCOG08684@2157|Archaea,41T64@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7308639_0	1459636.NTE_03154	1.995e-71	243.0	COG1601@1|root,arCOG01640@2157|Archaea,41STZ@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Translation initiation factor	-	-	-	ko:K03238	ko03013,map03013	-	-	-	ko00000,ko00001,ko01009,ko03012	-	-	-	eIF-5_eIF-2B
TLS1_k127_7308639_1	1459636.NTE_03149	2.365e-52	192.0	COG0576@1|root,arCOG04772@2157|Archaea,41SSU@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	-	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
TLS1_k127_7321770_0	1459636.NTE_01491	8.083e-26	112.0	COG0784@1|root,arCOG02391@2157|Archaea	1459636.NTE_01491|-	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7371940_4	1459636.NTE_02921	8.548e-49	177.0	COG0299@1|root,arCOG02825@2157|Archaea,41SH3@651137|Thaumarchaeota	651137|Thaumarchaeota	F	phosphoribosylglycinamide formyltransferase	-	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
TLS1_k127_7371940_2	1459636.NTE_02920	5.22e-101	340.0	COG1236@1|root,arCOG00545@2157|Archaea,41SYB@651137|Thaumarchaeota	651137|Thaumarchaeota	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	-
TLS1_k127_7371940_0	1459636.NTE_02919	4.528e-205	640.0	COG2141@1|root,arCOG02410@2157|Archaea,41SBM@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Luciferase-like monooxygenase	-	-	-	ko:K14728	-	-	-	-	ko00000,ko01000	-	-	-	Bac_luciferase
TLS1_k127_7371940_3	1459636.NTE_02186	3.349e-55	198.0	COG2522@1|root,arCOG00017@2157|Archaea,41SJZ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Transcriptional regulator	-	-	-	ko:K07108	-	-	-	-	ko00000	-	-	-	-
TLS1_k127_7371940_1	1459636.NTE_02050	6.424e-145	470.0	COG3635@1|root,arCOG01696@2157|Archaea,41S6M@651137|Thaumarchaeota	651137|Thaumarchaeota	G	phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
TLS1_k127_7437158_3	1459636.NTE_00426	2.025e-20	93.0	arCOG08809@1|root,arCOG08809@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7437158_2	1459636.NTE_00425	2.339e-34	139.0	COG1711@1|root,arCOG00551@2157|Archaea,41SVQ@651137|Thaumarchaeota	651137|Thaumarchaeota	L	protein conserved in archaea	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	-
TLS1_k127_7437158_5	1459636.NTE_01469	3.7e-08	61.0	COG1645@1|root,arCOG00578@2157|Archaea,41SVN@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27)	-	-	-	ko:K07143	-	-	-	-	ko00000	-	-	-	Auto_anti-p27
TLS1_k127_7437158_1	1131266.ARWQ01000001_gene1148	2.306e-81	276.0	COG2047@1|root,arCOG00348@2157|Archaea,41SFT@651137|Thaumarchaeota	651137|Thaumarchaeota	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
TLS1_k127_7437158_0	1459636.NTE_01645	1.548e-173	551.0	COG1260@1|root,arCOG04213@2157|Archaea,41SEZ@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
TLS1_k127_7445388_3	65489.OBART01G21800.1	0.0006343	43.0	COG4886@1|root,KOG0619@2759|Eukaryota,37JQI@33090|Viridiplantae,3G97Z@35493|Streptophyta,3M63V@4447|Liliopsida,3ITUB@38820|Poales	35493|Streptophyta	S	Leucine rich repeat N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	LRRNT_2,LRR_1,LRR_6,LRR_8
TLS1_k127_7445388_0	3694.POPTR_0008s21080.1	1.465e-07	53.0	KOG2469@1|root,KOG2469@2759|Eukaryota,37QAK@33090|Viridiplantae,3GE6Q@35493|Streptophyta,4JKMP@91835|fabids	35493|Streptophyta	F	Cytosolic purine	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid
TLS1_k127_7470042_0	1459636.NTE_02878	3.673e-213	674.0	COG1384@1|root,arCOG00485@2157|Archaea,41SB4@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
TLS1_k127_7470042_1	647113.Metok_0227	5.746e-131	436.0	COG1243@1|root,arCOG01361@2157|Archaea,2XT9Z@28890|Euryarchaeota,23Q36@183939|Methanococci	183939|Methanococci	K	SMART Elongator protein 3 MiaB NifB	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Acetyltransf_10,Radical_SAM,Radical_SAM_C
TLS1_k127_7470042_2	1459636.NTE_02880	5.389e-106	354.0	COG0150@1|root,arCOG00639@2157|Archaea,41SEE@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
TLS1_k127_7470042_4	1459636.NTE_00418	6.062e-17	83.0	COG0317@1|root,arCOG06870@2157|Archaea	2157|Archaea	KT	HD domain	-	-	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	HD_4
TLS1_k127_7502106_0	1459636.NTE_01742	5.939e-111	363.0	COG2513@1|root,arCOG00581@2157|Archaea,41SEN@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Phosphoenolpyruvate phosphomutase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
TLS1_k127_7502106_1	1229909.NSED_00825	8.355e-34	133.0	COG0328@1|root,arCOG02942@2157|Archaea,41SWJ@651137|Thaumarchaeota	651137|Thaumarchaeota	L	RNase H	-	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RVT_3
TLS1_k127_7510238_1	1423144.Gal_01393	1.876e-62	226.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS1_k127_7510238_0	1459636.NTE_03017	9.475e-83	280.0	COG0561@1|root,arCOG01213@2157|Archaea,41SIV@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Phosphoglycolate phosphatase	-	-	3.1.3.18	ko:K22223	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	Hydrolase_3
TLS1_k127_7510238_3	1131266.ARWQ01000011_gene123	1.242e-05	49.0	COG0018@1|root,arCOG00487@2157|Archaea,41SAI@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
TLS1_k127_7558560_4	1459636.NTE_00654	4.505e-20	91.0	arCOG08773@1|root,arCOG08773@2157|Archaea,41SNY@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7558560_1	1459636.NTE_00653	8.703e-53	195.0	COG0284@1|root,arCOG00081@2157|Archaea,41SMN@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Orotidine 5'-phosphate decarboxylase / HUMPS family	-	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
TLS1_k127_7558560_2	1459636.NTE_00652	5.524e-39	149.0	COG0494@1|root,arCOG01078@2157|Archaea,41SPS@651137|Thaumarchaeota	651137|Thaumarchaeota	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS1_k127_7558560_0	1459636.NTE_00400	2.492e-121	394.0	COG0020@1|root,arCOG01532@2157|Archaea,41S8J@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids	uppS	-	2.5.1.89	ko:K15888	ko00900,map00900	-	R09730	RC00279,RC02839	ko00000,ko00001,ko01000	-	-	-	Prenyltransf
TLS1_k127_7558560_3	1459636.NTE_00649	2.702e-38	146.0	COG2237@1|root,arCOG04151@2157|Archaea,41SA3@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Domain of unknown function (DUF373)	-	-	-	ko:K08975	-	-	-	-	ko00000	-	-	-	DUF373
TLS1_k127_755993_0	316274.Haur_2846	3.039e-96	327.0	COG0803@1|root,COG0803@2|Bacteria,2G8F6@200795|Chloroflexi,37738@32061|Chloroflexia	200795|Chloroflexi	P	Belongs to the bacterial solute-binding protein 9 family	-	-	-	ko:K02077,ko:K09815,ko:K09818	ko02010,map02010	M00242,M00243,M00244	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
TLS1_k127_755993_1	309799.DICTH_0359	3.467e-63	238.0	COG2723@1|root,COG2723@2|Bacteria	2|Bacteria	G	beta-glucosidase activity	bglB	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
TLS1_k127_7570965_7	1459636.NTE_02598	1.187e-32	130.0	COG0704@1|root,arCOG00318@2157|Archaea,41T1H@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Phosphate uptake regulator	-	-	-	-	-	-	-	-	-	-	-	-	PhoU
TLS1_k127_7570965_6	1459636.NTE_02599	7.34e-74	259.0	COG1829@1|root,arCOG04263@2157|Archaea,41T1V@651137|Thaumarchaeota	651137|Thaumarchaeota	S	kinase, sugar kinase superfamily	-	-	2.7.1.169	ko:K06982	ko00770,ko01100,map00770,map01100	-	R09378	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_N
TLS1_k127_7570965_5	1459636.NTE_02600	1.948e-82	281.0	COG1701@1|root,arCOG04262@2157|Archaea,41SXP@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Pfam:DUF137	-	-	6.3.2.36	ko:K09722	ko00410,ko00770,ko01100,map00410,map00770,map01100	-	R09379	RC00096,RC00141	ko00000,ko00001,ko01000	-	-	-	PPS_PS
TLS1_k127_7570965_4	1459636.NTE_02601	4.41e-93	314.0	COG0413@1|root,arCOG00584@2157|Archaea,41SZX@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
TLS1_k127_7570965_1	1459636.NTE_02602	2.27e-127	420.0	COG0452@1|root,arCOG01704@2157|Archaea,41SYG@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
TLS1_k127_7570965_2	1459636.NTE_02604	5.909e-100	340.0	COG0006@1|root,arCOG01000@2157|Archaea,41T14@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the peptidase M24B family	-	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
TLS1_k127_7570965_0	1459636.NTE_02607	7.571e-179	566.0	COG0075@1|root,arCOG00082@2157|Archaea,41SZZ@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS1_k127_7570965_3	1459636.NTE_02621	2.873e-96	321.0	COG1047@1|root,arCOG00980@2157|Archaea,41T0T@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Peptidyl-prolyl cis-trans	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
TLS1_k127_7570965_8	1459636.NTE_01413	6.72e-21	94.0	COG0371@1|root,arCOG00982@2157|Archaea,41T0B@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea	egsA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
TLS1_k127_757113_0	1459636.NTE_02003	1.932e-148	480.0	COG0750@1|root,arCOG04064@2157|Archaea,41SW5@651137|Thaumarchaeota	651137|Thaumarchaeota	M	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M50
TLS1_k127_7591489_2	1459636.NTE_00967	2.275e-32	138.0	arCOG08732@1|root,arCOG08732@2157|Archaea,41SR6@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7591489_1	1459636.NTE_02704	1.737e-40	150.0	arCOG08662@1|root,arCOG08662@2157|Archaea,41SQG@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7591489_4	1131266.ARWQ01000010_gene36	1.336e-16	79.0	arCOG11928@1|root,arCOG11928@2157|Archaea,41T8Q@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7591489_0	1459636.NTE_00963	4.717e-45	171.0	arCOG08733@1|root,arCOG08733@2157|Archaea,41SRN@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7592490_1	1459636.NTE_00136	1.44e-11	67.0	COG1938@1|root,arCOG00347@2157|Archaea,41SSA@651137|Thaumarchaeota	651137|Thaumarchaeota	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
TLS1_k127_7592490_0	1459636.NTE_00136	5.775e-38	147.0	COG1938@1|root,arCOG00347@2157|Archaea,41SSA@651137|Thaumarchaeota	651137|Thaumarchaeota	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
TLS1_k127_7596183_2	224719.Abm4_1366	4.45e-62	224.0	COG0157@1|root,arCOG01482@2157|Archaea,2XTTY@28890|Euryarchaeota,23NNA@183925|Methanobacteria	183925|Methanobacteria	H	Involved in the catabolism of quinolinic acid (QA)	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
TLS1_k127_7596183_3	1459636.NTE_01704	2.154e-19	88.0	COG2093@1|root,arCOG04077@2157|Archaea,41SVE@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Transcription elongation factor Spt4	spt4	-	2.7.7.6	ko:K03050	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Spt4
TLS1_k127_7596183_1	1459636.NTE_01705	3.488e-93	310.0	COG1095@1|root,arCOG00675@2157|Archaea,41SGF@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-directed RNA polymerase	-	-	2.7.7.6	ko:K03049	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	S1,SHS2_Rpb7-N
TLS1_k127_7596183_0	1459636.NTE_01706	1.411e-172	547.0	COG0489@1|root,arCOG01846@1|root,arCOG00585@2157|Archaea,arCOG01846@2157|Archaea,41SF1@651137|Thaumarchaeota	651137|Thaumarchaeota	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
TLS1_k127_7596183_4	1151117.AJLF01000003_gene664	7.232e-17	87.0	COG1909@1|root,arCOG04076@2157|Archaea,2XXSG@28890|Euryarchaeota,2440N@183968|Thermococci	183968|Thermococci	S	Belongs to the UPF0218 family	-	-	-	ko:K09735	-	-	-	-	ko00000	-	-	-	DUF359
TLS1_k127_7614089_0	1459636.NTE_03035	1.303e-218	684.0	COG3276@1|root,arCOG01563@2157|Archaea,41S80@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Initiation factor	-	-	-	ko:K03242	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,eIF2_C
TLS1_k127_7614089_1	1459636.NTE_03187	4.517e-113	375.0	COG0517@1|root,arCOG00601@2157|Archaea	2157|Archaea	C	CBS domain	cbs1	-	-	-	-	-	-	-	-	-	-	-	CBS,Ribosomal_S30AE
TLS1_k127_7614089_2	1459636.NTE_03037	7.174e-77	263.0	COG2220@1|root,arCOG00497@2157|Archaea	2157|Archaea	S	Zn-dependent hydrolases of the beta-lactamase fold	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
TLS1_k127_7619181_5	1459636.NTE_01345	1.495e-25	106.0	COG1997@1|root,arCOG04208@2157|Archaea,41SUE@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Ribosomal L37ae protein family	rpl37ae	-	-	ko:K02921	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37ae
TLS1_k127_7619181_3	1459636.NTE_01347	3.161e-47	173.0	COG1382@1|root,arCOG01342@2157|Archaea,41SPD@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdB	-	-	ko:K04798	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin_2
TLS1_k127_7619181_2	1459636.NTE_01348	4.548e-66	234.0	COG1948@1|root,arCOG04206@2157|Archaea,41SIH@651137|Thaumarchaeota	651137|Thaumarchaeota	L	ERCC4 domain	-	-	-	ko:K10848	ko03420,ko03460,map03420,map03460	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	ERCC4,HHH_5
TLS1_k127_7619181_4	1459636.NTE_03211	5.455e-32	130.0	arCOG08827@1|root,arCOG08827@2157|Archaea,41SUW@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7619181_0	1459636.NTE_03210	1.027e-97	326.0	COG0077@1|root,arCOG00255@2157|Archaea,41SA8@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Prephenate dehydratase	-	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
TLS1_k127_7619181_1	1459636.NTE_03209	9.733e-70	243.0	COG1096@1|root,arCOG00676@2157|Archaea,41SQA@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs	csl4	-	-	ko:K07573	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	-
TLS1_k127_7619181_6	1459636.NTE_03217	1.452e-17	90.0	COG1634@1|root,arCOG04303@2157|Archaea,41SKX@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP)	mptE	-	2.7.6.3	ko:K07142	ko00790,map00790	-	R03503	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	MAF_flag10
TLS1_k127_7620377_2	1459636.NTE_00789	9.243e-05	46.0	COG1060@1|root,arCOG00656@2157|Archaea,41SEG@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Radical SAM	-	-	2.5.1.120	ko:K18285	ko00130,ko01110,map00130,map01110	-	R10667	RC00021,RC03234	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
TLS1_k127_7620377_1	1459636.NTE_00788	1.118e-172	548.0	COG1060@1|root,arCOG00656@2157|Archaea,41SCN@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS1_k127_7620377_0	1459636.NTE_01316	8.838e-240	747.0	COG3425@1|root,arCOG01767@2157|Archaea,41SAQ@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Hydroxymethylglutaryl-coenzyme A synthase N terminal	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	HMG_CoA_synt_C,HMG_CoA_synt_N
TLS1_k127_7628121_1	1459636.NTE_00930	7.504e-100	352.0	COG1361@1|root,arCOG02080@2157|Archaea,41T6N@651137|Thaumarchaeota	651137|Thaumarchaeota	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7628121_0	1459636.NTE_01104	4.346e-100	332.0	COG1136@1|root,arCOG00922@2157|Archaea,41T2R@651137|Thaumarchaeota	651137|Thaumarchaeota	E	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003,ko:K09810	ko02010,map02010	M00255,M00258	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.125	-	-	ABC_tran
TLS1_k127_7628488_0	1459636.NTE_02504	4.198e-104	352.0	COG0265@1|root,arCOG02833@2157|Archaea,41S9W@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Trypsin-like serine protease with C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
TLS1_k127_7628488_1	1459636.NTE_01553	5.312e-32	127.0	arCOG12283@1|root,arCOG12283@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7651443_4	1459636.NTE_02766	3.54e-33	131.0	arCOG08783@1|root,arCOG08783@2157|Archaea,41SFX@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7651443_1	1459636.NTE_02745	6.605e-102	334.0	COG0049@1|root,arCOG04254@2157|Archaea,41S6U@651137|Thaumarchaeota	651137|Thaumarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center	rps7	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
TLS1_k127_7651443_2	1459636.NTE_02746	1.316e-76	258.0	COG0048@1|root,arCOG04255@2157|Archaea,41SIB@651137|Thaumarchaeota	651137|Thaumarchaeota	J	With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits	rps12	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
TLS1_k127_7651443_3	1459636.NTE_02747	3.221e-65	226.0	COG0195@1|root,arCOG01760@2157|Archaea,41SJQ@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Participates in transcription termination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_2
TLS1_k127_7651443_5	523850.TON_0220	7.741e-08	57.0	COG1911@1|root,arCOG01752@2157|Archaea,2Y0CU@28890|Euryarchaeota,244AG@183968|Thermococci	183968|Thermococci	J	structural constituent of ribosome	rpl30e	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02908	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L7Ae
TLS1_k127_7651443_0	1459636.NTE_02749	0.0	1407.0	COG0086@1|root,arCOG04256@2157|Archaea,arCOG04257@2157|Archaea,41SB2@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	-	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
TLS1_k127_7711729_0	1459636.NTE_03316	1.952e-199	628.0	COG1236@1|root,arCOG00541@2157|Archaea,41SAJ@651137|Thaumarchaeota	651137|Thaumarchaeota	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B_6,RMMBL
TLS1_k127_7711729_1	1459636.NTE_03312	2.356e-07	53.0	arCOG02703@1|root,arCOG02703@2157|Archaea	2157|Archaea	S	Methyltransferase type 11	aknG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
TLS1_k127_7770635_1	1459636.NTE_02630	1.898e-57	203.0	COG1522@1|root,arCOG01580@2157|Archaea,41T4E@651137|Thaumarchaeota	651137|Thaumarchaeota	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
TLS1_k127_7770635_0	485913.Krac_8002	6.012e-137	453.0	COG1012@1|root,COG1012@2|Bacteria,2G5JE@200795|Chloroflexi	200795|Chloroflexi	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS1_k127_7795867_1	1459636.NTE_00076	4.152e-55	195.0	COG0498@1|root,arCOG01434@2157|Archaea,41SEI@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS1_k127_7795867_0	1459636.NTE_00071	8.958e-154	497.0	COG1571@1|root,arCOG01115@2157|Archaea,41S9G@651137|Thaumarchaeota	651137|Thaumarchaeota	J	ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA	tiaS	-	6.3.4.22	ko:K06932	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1743
TLS1_k127_7830653_2	436308.Nmar_1599	3.612e-09	61.0	arCOG08662@1|root,arCOG08662@2157|Archaea,41SQG@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7830653_1	1459636.NTE_00830	7.615e-34	134.0	COG3324@1|root,arCOG04946@2157|Archaea	2157|Archaea	S	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	-
TLS1_k127_7830653_0	530564.Psta_3548	1.907e-40	154.0	COG2062@1|root,COG2062@2|Bacteria,2J0N8@203682|Planctomycetes	203682|Planctomycetes	T	phosphohistidine phosphatase, SixA	-	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
TLS1_k127_7837464_0	272562.CA_C2199	3.23e-85	291.0	COG3882@1|root,COG3882@2|Bacteria,1TTCC@1239|Firmicutes,24A4U@186801|Clostridia,36G4Q@31979|Clostridiaceae	186801|Clostridia	Q	HAD-superfamily phosphatase, subfamily IIIC	-	-	-	-	-	-	-	-	-	-	-	-	NIF
TLS1_k127_7837464_2	1150864.MILUP08_44388	4.076e-08	57.0	COG0236@1|root,COG0236@2|Bacteria,2I7G4@201174|Actinobacteria	201174|Actinobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7837464_1	1408287.AXUR01000002_gene1381	3.684e-27	115.0	COG2030@1|root,COG2030@2|Bacteria,37BSZ@32066|Fusobacteria	32066|Fusobacteria	I	N-terminal half of MaoC dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
TLS1_k127_7853048_3	1459636.NTE_01721	8.743e-34	133.0	arCOG08766@1|root,arCOG08766@2157|Archaea,41T41@651137|Thaumarchaeota	651137|Thaumarchaeota	G	dUTPase	-	-	-	-	-	-	-	-	-	-	-	-	dUTPase_2
TLS1_k127_7853048_2	1459636.NTE_01725	1.032e-34	134.0	COG1958@1|root,arCOG00998@2157|Archaea,41SS5@651137|Thaumarchaeota	651137|Thaumarchaeota	K	snRNP Sm proteins	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
TLS1_k127_7853048_0	1459636.NTE_01726	1.31e-194	612.0	COG0192@1|root,arCOG07444@2157|Archaea,41S5P@651137|Thaumarchaeota	651137|Thaumarchaeota	H	S-adenosylmethionine synthetase	-	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
TLS1_k127_7853048_1	1459636.NTE_01727	5.383e-84	285.0	COG1028@1|root,arCOG01259@2157|Archaea,41SXY@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS1_k127_7869252_1	1459636.NTE_01808	1.814e-91	303.0	COG1961@1|root,arCOG03162@2157|Archaea	2157|Archaea	L	resolvase	-	-	-	ko:K14060	-	-	-	-	ko00000	-	-	-	HTH_7,Recombinase,Resolvase
TLS1_k127_7869252_0	1459636.NTE_01809	7.112e-154	497.0	COG0161@1|root,arCOG00917@2157|Archaea,41S7K@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS1_k127_7869252_2	1459636.NTE_01810	2.955e-48	180.0	COG0132@1|root,arCOG00100@2157|Archaea,41SQX@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	-	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
TLS1_k127_7884647_0	1459636.NTE_00119	1.183e-118	383.0	COG2406@1|root,arCOG01093@2157|Archaea,41S6X@651137|Thaumarchaeota	2157|Archaea	S	Ferritin-like domain	dps	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
TLS1_k127_7884647_1	1459636.NTE_01052	7.691e-97	336.0	COG0642@1|root,arCOG02358@2157|Archaea,41T5G@651137|Thaumarchaeota	651137|Thaumarchaeota	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,dCache_1
TLS1_k127_791629_0	1459636.NTE_02036	6.541e-232	723.0	COG0422@1|root,arCOG02741@2157|Archaea,41S5Z@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Thiamine biosynthesis protein ThiC	-	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
TLS1_k127_7952207_0	1459636.NTE_00933	4.321e-185	590.0	COG0527@1|root,arCOG00861@2157|Archaea,41SFA@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT_7
TLS1_k127_7952207_2	1459636.NTE_00916	7.884e-131	421.0	COG1010@1|root,arCOG00647@2157|Archaea,41S6W@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	-	-	2.1.1.131	ko:K05934	ko00860,ko01100,map00860,map01100	-	R05180,R05809	RC00003,RC01293,RC03471	ko00000,ko00001,ko01000	-	-	-	TP_methylase
TLS1_k127_7952207_1	1459636.NTE_01075	4.538e-148	476.0	COG0162@1|root,arCOG01886@2157|Archaea,41S8C@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Tyrosine--tRNA ligase	-	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
TLS1_k127_7954620_1	1459636.NTE_02213	5.622e-63	218.0	COG1100@1|root,arCOG01225@2157|Archaea,41T0A@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Conserved hypothetical ATP binding protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	ATP_bind_1
TLS1_k127_7954620_0	1459636.NTE_02215	7.548e-115	381.0	COG0392@1|root,arCOG00899@2157|Archaea,41SFV@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
TLS1_k127_7954620_2	1459636.NTE_02216	7.966e-44	164.0	arCOG10514@1|root,arCOG10514@2157|Archaea,41STR@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7954620_3	1459636.NTE_03073	1.389e-24	104.0	arCOG08805@1|root,arCOG08805@2157|Archaea	1459636.NTE_03073|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_7959253_0	1131266.ARWQ01000006_gene279	2.335e-52	189.0	arCOG00516@1|root,arCOG00516@2157|Archaea,41T43@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Pyridoxamine 5'-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS1_k127_7959253_2	195522.BD01_0352	3.812e-06	51.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,242WT@183968|Thermococci	183968|Thermococci	M	Hexapeptide repeat of succinyl-transferase	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
TLS1_k127_7965394_0	1459636.NTE_03195	5.625e-150	480.0	COG0040@1|root,arCOG02208@2157|Archaea,41SCJ@651137|Thaumarchaeota	651137|Thaumarchaeota	E	ATP phosphoribosyltransferase	-	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
TLS1_k127_7965394_1	1459636.NTE_03194	2.512e-141	460.0	COG1257@1|root,arCOG04260@2157|Archaea,41SAU@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Belongs to the HMG-CoA reductase family	-	-	1.1.1.88	ko:K00054	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R02081	RC00004,RC00644	ko00000,ko00001,ko01000	-	-	-	HMG-CoA_red
TLS1_k127_7965394_2	1131266.ARWQ01000010_gene29	8.725e-08	61.0	COG3794@1|root,arCOG02926@2157|Archaea	2157|Archaea	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind
TLS1_k127_7980367_3	1459636.NTE_01228	1.442e-66	234.0	COG0311@1|root,arCOG00034@2157|Archaea,41SIZ@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	-	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
TLS1_k127_7980367_1	1459636.NTE_01229	4.584e-152	485.0	COG0214@1|root,arCOG04075@2157|Archaea,41SEJ@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Belongs to the PdxS SNZ family	-	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
TLS1_k127_7980367_0	1459636.NTE_01233	1.89e-272	852.0	COG0674@1|root,arCOG01606@2157|Archaea,41S60@651137|Thaumarchaeota	651137|Thaumarchaeota	C	pyruvate flavodoxin ferredoxin oxidoreductase	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
TLS1_k127_7980367_2	869210.Marky_0696	7.787e-122	398.0	COG1013@1|root,COG1013@2|Bacteria,1WIGM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	TIGRFAM 2-oxoacid acceptor oxidoreductase, beta subunit, pyruvate 2-ketoisovalerate family	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
TLS1_k127_7980367_4	1459636.NTE_00961	1.524e-19	87.0	arCOG08676@1|root,arCOG08676@2157|Archaea,41SCF@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Archaeal ammonia monooxygenase subunit A (AmoA)	-	-	1.14.18.3,1.14.99.39	ko:K10944	ko00680,ko00910,ko01100,ko01120,ko01200,map00680,map00910,map01100,map01120,map01200	M00174,M00528,M00804	R00148,R09518	RC00173,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	Archaeal_AmoA
TLS1_k127_8004689_0	1459636.NTE_02924	0.0	1102.0	COG1205@1|root,arCOG00555@2157|Archaea,41SZS@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DEAD DEAH box helicase	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
TLS1_k127_8015549_0	1459636.NTE_00050	1.625e-117	396.0	COG0248@1|root,arCOG05138@2157|Archaea	2157|Archaea	FP	PFAM Ppx GppA phosphatase	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,Ppx-GppA
TLS1_k127_8015549_2	1459636.NTE_00049	8.597e-41	156.0	COG2062@1|root,arCOG01992@2157|Archaea	2157|Archaea	T	TIGRFAM phosphohistidine phosphatase SixA	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
TLS1_k127_8015549_1	1459636.NTE_02330	3.206e-72	248.0	arCOG10136@1|root,arCOG10136@2157|Archaea,41T5E@651137|Thaumarchaeota	651137|Thaumarchaeota	S	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)	-	-	-	ko:K05967	-	-	-	-	ko00000	-	-	-	NT5C
TLS1_k127_8045199_0	1459636.NTE_00019	8.571e-163	519.0	COG0527@1|root,arCOG00861@2157|Archaea,41SFK@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Amino acid kinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
TLS1_k127_8045199_1	1459636.NTE_01302	7.835e-112	365.0	COG1866@1|root,arCOG06073@2157|Archaea,41SE5@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
TLS1_k127_8072166_2	1459636.NTE_00982	1.921e-84	284.0	COG0436@1|root,arCOG01131@2157|Archaea,41S8G@651137|Thaumarchaeota	651137|Thaumarchaeota	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
TLS1_k127_8072166_4	1459636.NTE_02304	2.468e-44	163.0	COG1581@1|root,arCOG01753@2157|Archaea,41SQ4@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	-	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
TLS1_k127_8072166_3	1459636.NTE_02305	2.506e-68	238.0	COG1056@1|root,arCOG00972@2157|Archaea,41SHQ@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Nicotinamide-nucleotide adenylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_8072166_0	1459636.NTE_02306	1.48e-135	437.0	COG0115@1|root,arCOG02297@2157|Archaea,41S5T@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
TLS1_k127_8072166_1	1229909.NSED_01150	1.144e-108	360.0	COG0673@1|root,arCOG01622@2157|Archaea,41SZ6@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	1.1.1.374	ko:K18855	-	-	-	-	ko00000,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS1_k127_866413_0	1459636.NTE_01458	3.233e-28	116.0	arCOG10549@1|root,arCOG10549@2157|Archaea	1459636.NTE_01458|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_866413_2	1131266.ARWQ01000003_gene1553	1.933e-16	83.0	COG0736@1|root,arCOG08267@2157|Archaea	2157|Archaea	I	transferase	-	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
TLS1_k127_866413_1	1163730.FFONT_1039	4.652e-17	93.0	COG1208@1|root,arCOG00666@2157|Archaea,2XQH5@28889|Crenarchaeota	28889|Crenarchaeota	M	Transferase hexapeptide repeat containing protein	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3,NTP_transferase
TLS1_k127_883331_4	273063.STK_04060	2.124e-17	85.0	COG1371@1|root,arCOG04055@2157|Archaea,2XQYK@28889|Crenarchaeota	28889|Crenarchaeota	J	Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently	-	-	-	-	-	-	-	-	-	-	-	-	Archease
TLS1_k127_883331_1	1459636.NTE_01199	2.176e-59	207.0	COG0526@1|root,arCOG01972@2157|Archaea,41T6S@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Thioredoxin	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
TLS1_k127_883331_0	1459636.NTE_01200	4.534e-276	859.0	COG0532@1|root,arCOG01560@2157|Archaea,41SBY@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D4,IF-2
TLS1_k127_883331_2	1459636.NTE_01201	1.945e-52	188.0	COG0105@1|root,arCOG04313@2157|Archaea,41SN1@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
TLS1_k127_883331_3	1459636.NTE_01202	2.147e-20	90.0	COG2075@1|root,arCOG01950@2157|Archaea,41T7M@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Binds to the 23S rRNA	rpl24e	-	-	ko:K02896	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L24e
TLS1_k127_919841_2	1423758.BN55_06295	5.498e-08	61.0	COG1340@1|root,COG1340@2|Bacteria,1UI94@1239|Firmicutes,4HFS7@91061|Bacilli,3FBT5@33958|Lactobacillaceae	91061|Bacilli	J	Ion channel	-	-	2.1.1.172	ko:K00564,ko:K10716	-	-	R07234	RC00003	ko00000,ko01000,ko02000,ko03009	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans,Ion_trans_2
TLS1_k127_919841_0	1459636.NTE_03308	2.293e-43	166.0	COG1515@1|root,arCOG00929@2157|Archaea	2157|Archaea	L	DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA	nfi	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
TLS1_k127_919841_1	1459636.NTE_01273	3.346e-19	90.0	arCOG03899@1|root,arCOG03899@2157|Archaea	2157|Archaea	L	endonuclease	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	HNH,HNH_3
TLS1_k127_966934_1	1459636.NTE_00971	3.684e-28	117.0	COG0500@1|root,arCOG01787@2157|Archaea	2157|Archaea	Q	PFAM Methyltransferase type	-	-	-	ko:K15256	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_12,Methyltransf_25,Methyltransf_31
TLS1_k127_966934_0	1459636.NTE_01965	3.462e-79	273.0	COG1467@1|root,arCOG04110@2157|Archaea,41SCB@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	-	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
TLS1_k127_994140_0	1459636.NTE_01313	1.105e-96	331.0	arCOG08812@1|root,arCOG08812@2157|Archaea,41SXB@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS1_k127_994140_1	1459636.NTE_00859	2.614e-18	91.0	COG4742@1|root,arCOG04362@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
## 1028 queries scanned
## Total time (seconds): 16.591710090637207
## Rate: 61.96 q/s